diff --git a/.github/workflows/python.yml b/.github/workflows/python.yml
index f6cc4099..d876570d 100644
--- a/.github/workflows/python.yml
+++ b/.github/workflows/python.yml
@@ -41,7 +41,7 @@ jobs:
     - name: Install Python tools
       run: |
         python -m pip install --upgrade pip
-        pip install build jinja2 pytest
+        pip install auditwheel build jinja2 setuptools pytest
     - name: Install OpenSlide
       run: |
         case "${{ matrix.os }}" in
@@ -53,13 +53,36 @@ jobs:
           ;;
         esac
     - name: Build wheel
-      run: python -m build -w
+      run: |
+        if [[ "${{ matrix.os }}" == macos-* ]]; then
+            py_cflags=$(python -c 'import sysconfig; print(sysconfig.get_config_vars()["CFLAGS"])')
+            echo "Python compile flags: $py_cflags"
+            if [[ $py_cflags !~ "-arch x86_64" || $py_cflags !~ "-arch arm64" ]]; then
+                echo "Working around missing universal binary flags"
+                export CFLAGS="-arch x86_64 -arch arm64"
+                export LDFLAGS="$CFLAGS"
+            fi
+        fi
+        python -m build -w
+        if [[ "${{ matrix.os }}" == ubuntu-* ]]; then
+            mv dist old
+            auditwheel repair --only-plat -w dist old/*whl
+        fi
+        basename=openslide-python-wheels-$GITHUB_RUN_NUMBER-$(echo $GITHUB_SHA | cut -c-10)
+        mkdir -p "artifacts/${basename}"
+        mv dist/*.whl "artifacts/${basename}"
+        echo "basename=${basename}" >> $GITHUB_ENV
     - name: Install
-      run: pip install dist/*.whl
+      run: pip install artifacts/${basename}/*.whl
     - name: Run tests
       run: pytest -v
     - name: Tile slide
       run: python examples/deepzoom/deepzoom_tile.py --viewer -o tiled tests/fixtures/small.svs
+    - name: Archive wheel
+      uses: actions/upload-artifact@v3
+      with:
+        name: ${{ env.basename }}
+        path: artifacts
   windows:
     name: Windows
     needs: pre-commit