diff --git a/.github/workflows/python.yml b/.github/workflows/python.yml
index f6cc4099..ec316ade 100644
--- a/.github/workflows/python.yml
+++ b/.github/workflows/python.yml
@@ -31,17 +31,36 @@ jobs:
       matrix:
         os: [ubuntu-latest, macos-latest]
         python-version: [3.8, 3.9, "3.10", "3.11", "3.12"]
+        # setup-python Python < 3.11 doesn't support universal binaries
+        # https://github.com/actions/setup-python/issues/439#issuecomment-1247646682
+        include:
+          - os: macos-latest
+            python-version: "3.8"
+            brew-python: true
+          - os: macos-latest
+            python-version: "3.9"
+            brew-python: true
+          - os: macos-latest
+            python-version: "3.10"
+            brew-python: true
     steps:
     - name: Check out repo
       uses: actions/checkout@v4
     - name: Set up Python ${{ matrix.python-version }}
+      if: "! matrix.brew-python"
       uses: actions/setup-python@v4
       with:
         python-version: ${{ matrix.python-version }}
+    - name: Set up Python ${{ matrix.python-version }} (macOS fallback)
+      if: matrix.brew-python
+      run: |
+        brew install python${{matrix.python-version}}
+        python -V
+        pip -V
     - name: Install Python tools
       run: |
         python -m pip install --upgrade pip
-        pip install build jinja2 pytest
+        pip install auditwheel build jinja2 pytest setuptools
     - name: Install OpenSlide
       run: |
         case "${{ matrix.os }}" in
@@ -53,13 +72,36 @@ jobs:
           ;;
         esac
     - name: Build wheel
-      run: python -m build -w
+      run: |
+        python -m build -w
+        case "${{ matrix.os }}" in
+        ubuntu-*)
+            mv dist old
+            auditwheel repair --only-plat -w dist old/*whl
+            ;;
+        macos-*)
+            if [ ! -e dist/*universal2* ]; then
+                echo "Wheel is not universal:"
+                ls dist
+                exit 1
+            fi
+            ;;
+        esac
+        basename=openslide-python-wheels-$GITHUB_RUN_NUMBER-$(echo $GITHUB_SHA | cut -c-10)
+        mkdir -p "artifacts/${basename}"
+        mv dist/*.whl "artifacts/${basename}"
+        echo "basename=${basename}" >> $GITHUB_ENV
     - name: Install
-      run: pip install dist/*.whl
+      run: pip install artifacts/${basename}/*.whl
     - name: Run tests
       run: pytest -v
     - name: Tile slide
       run: python examples/deepzoom/deepzoom_tile.py --viewer -o tiled tests/fixtures/small.svs
+    - name: Archive wheel
+      uses: actions/upload-artifact@v3
+      with:
+        name: ${{ env.basename }}
+        path: artifacts
   windows:
     name: Windows
     needs: pre-commit