diff --git a/tools/osx/crosstool/wrapped_clang.cc b/tools/osx/crosstool/wrapped_clang.cc
index 6b632a95c33c06..9dec7b04668abd 100644
--- a/tools/osx/crosstool/wrapped_clang.cc
+++ b/tools/osx/crosstool/wrapped_clang.cc
@@ -272,19 +272,23 @@ static std::unique_ptr<TempFile> WriteResponseFile(
 }
 
 void ProcessArgument(
-    const std::string &arg,
+    const std::string arg,
     const std::string developer_dir,
     const std::string sdk_root,
     const std::string cwd,
     bool relative_ast_path,
+    std::string &linked_binary,
+    std::string &dsym_path,
     std::function<void(const std::string &)> consumer);
 
 bool ProcessResponseFile(
-    const std::string &arg,
+    const std::string arg,
     const std::string developer_dir,
     const std::string sdk_root,
     const std::string cwd,
     bool relative_ast_path,
+    std::string &linked_binary,
+    std::string &dsym_path,
     std::function<void(const std::string &)> consumer) {
   auto path = arg.substr(1);
   std::ifstream original_file(path);
@@ -299,7 +303,7 @@ bool ProcessResponseFile(
     // unescape them ourselves.
     ProcessArgument(
         Unescape(arg_from_file), developer_dir, sdk_root, cwd,
-        relative_ast_path, consumer);
+        relative_ast_path, linked_binary, dsym_path, consumer);
   }
 
   return true;
@@ -314,20 +318,43 @@ std::string GetCurrentDirectory() {
 }
 
 void ProcessArgument(
-    const std::string &arg,
+    const std::string arg,
     const std::string developer_dir,
     const std::string sdk_root,
     const std::string cwd,
     bool relative_ast_path,
+    std::string &linked_binary,
+    std::string &dsym_path,
     std::function<void(const std::string &)> consumer) {
   auto new_arg = arg;
   if (arg[0] == '@') {
     if (ProcessResponseFile(arg, developer_dir, sdk_root, cwd,
-          relative_ast_path, consumer)) {
+          relative_ast_path, linked_binary, dsym_path, consumer)) {
       return;
     }
   }
 
+  if (SetArgIfFlagPresent(arg, "DSYM_HINT_LINKED_BINARY", &linked_binary)) {
+    return;
+  }
+  if (SetArgIfFlagPresent(arg, "DSYM_HINT_DSYM_PATH", &dsym_path)) {
+    return;
+  }
+
+  std::string dest_dir, bitcode_symbol_map;
+  if (SetArgIfFlagPresent(arg, "DEBUG_PREFIX_MAP_PWD", &dest_dir)) {
+    new_arg = "-fdebug-prefix-map=" + cwd + "=" + dest_dir;
+  }
+  if (arg.compare("OSO_PREFIX_MAP_PWD") == 0) {
+    new_arg = "-Wl,-oso_prefix," + cwd + "/";
+  }
+  if (SetArgIfFlagPresent(arg, "BITCODE_TOUCH_SYMBOL_MAP",
+                          &bitcode_symbol_map)) {
+    // Touch bitcode_symbol_map.
+    std::ofstream bitcode_symbol_map_file(bitcode_symbol_map);
+    new_arg = bitcode_symbol_map;
+  }
+
   FindAndReplace("__BAZEL_XCODE_DEVELOPER_DIR__", developer_dir, &new_arg);
   FindAndReplace("__BAZEL_XCODE_SDKROOT__", sdk_root, &new_arg);
 
@@ -366,9 +393,7 @@ int main(int argc, char *argv[]) {
 
   std::string developer_dir = GetMandatoryEnvVar("DEVELOPER_DIR");
   std::string sdk_root = GetMandatoryEnvVar("SDKROOT");
-
-  std::string linked_binary, dsym_path, bitcode_symbol_map;
-  std::string dest_dir;
+  std::string linked_binary, dsym_path;
 
   const std::string cwd = GetCurrentDirectory();
   std::vector<std::string> invocation_args = {"/usr/bin/xcrun", tool_name};
@@ -379,25 +404,9 @@ int main(int argc, char *argv[]) {
   for (int i = 1; i < argc; i++) {
     std::string arg(argv[i]);
 
-    // These args are not read from response files to simplify assignment
-    if (SetArgIfFlagPresent(arg, "DSYM_HINT_LINKED_BINARY", &linked_binary)) {
-      continue;
-    }
-    if (SetArgIfFlagPresent(arg, "DSYM_HINT_DSYM_PATH", &dsym_path)) {
-      continue;
-    }
-    if (SetArgIfFlagPresent(arg, "BITCODE_TOUCH_SYMBOL_MAP",
-                            &bitcode_symbol_map)) {
-      // Touch bitcode_symbol_map.
-      std::ofstream bitcode_symbol_map_file(bitcode_symbol_map);
-      arg = bitcode_symbol_map;
-    }
-    if (SetArgIfFlagPresent(arg, "DEBUG_PREFIX_MAP_PWD", &dest_dir)) {
-      arg = "-fdebug-prefix-map=" + std::string(cwd) + "=" + dest_dir;
-    }
-
     ProcessArgument(
-        arg, developer_dir, sdk_root, cwd, relative_ast_path, consumer);
+        arg, developer_dir, sdk_root, cwd, relative_ast_path, linked_binary,
+        dsym_path, consumer);
   }
 
   // Special mode that only prints the command. Used for testing.