diff --git a/PopPUNK/mandrake.py b/PopPUNK/mandrake.py
index 2d14a350..fc9e81f5 100644
--- a/PopPUNK/mandrake.py
+++ b/PopPUNK/mandrake.py
@@ -70,23 +70,29 @@ def generate_embedding(seqLabels, accMat, perplexity, outPrefix, overwrite, kNN
         weights = np.ones((len(seqLabels)))
         random.Random()
         seed = random.randint(0, 2**32)
-        if use_gpu and gpu_fn_available:
-            sys.stderr.write("Running on GPU\n")
-            n_workers = 65536
-            maxIter = round(maxIter / n_workers)
-            wtsne_call = partial(wtsne_gpu_fp64,
-                                perplexity=perplexity,
-                                maxIter=maxIter,
-                                blockSize=128,
-                                n_workers=n_workers,
-                                nRepuSamp=5,
-                                eta0=1,
-                                bInit=0,
-                                animated=False,
-                                cpu_threads=n_threads,
-                                device_id=device_id,
-                                seed=seed)
-        else:
+        gpu_analysis_complete = False
+        try:
+          if use_gpu and gpu_fn_available:
+              sys.stderr.write("Running on GPU\n")
+              n_workers = 65536
+              maxIter = round(maxIter / n_workers)
+              wtsne_call = partial(wtsne_gpu_fp64,
+                                  perplexity=perplexity,
+                                  maxIter=maxIter,
+                                  blockSize=128,
+                                  n_workers=n_workers,
+                                  nRepuSamp=5,
+                                  eta0=1,
+                                  bInit=0,
+                                  animated=False,
+                                  cpu_threads=n_threads,
+                                  device_id=device_id,
+                                  seed=seed)
+              gpu_analysis_complete = True
+        except:
+          # If installed through conda/mamba mandrake is not GPU-enabled by default
+          sys.stderr.write('Mandrake analysis with GPU failed; trying with CPU\n')
+        if not gpu_analysis_complete:
             sys.stderr.write("Running on CPU\n")
             maxIter = round(maxIter / n_threads)
             wtsne_call = partial(wtsne,