diff --git a/.changes/next-release/bugfix-s3-56735.json b/.changes/next-release/bugfix-s3-56735.json
new file mode 100644
index 000000000000..cc92c0aec7e6
--- /dev/null
+++ b/.changes/next-release/bugfix-s3-56735.json
@@ -0,0 +1,5 @@
+{
+  "category": "``s3``", 
+  "type": "bugfix", 
+  "description": "Fix issue where setting ``addressing_style`` and ``use_accelerate_endpoint`` in your config file would cause ``aws s3`` commands using S3 streams to fail (`#2146 <https://github.com/aws/aws-cli/issues/2146>`__)"
+}
diff --git a/awscli/customizations/s3/transferconfig.py b/awscli/customizations/s3/transferconfig.py
index bf720d86b220..575299308033 100644
--- a/awscli/customizations/s3/transferconfig.py
+++ b/awscli/customizations/s3/transferconfig.py
@@ -91,12 +91,13 @@ def create_transfer_config_from_runtime_config(runtime_config):
     """
     translation_map = {
         'max_concurrent_requests': 'max_request_concurrency',
-        'max_queue_size': 'max_request_queue_size'
+        'max_queue_size': 'max_request_queue_size',
+        'multipart_threshold': 'multipart_threshold',
+        'multipart_chunksize': 'multipart_chunksize',
     }
     kwargs = {}
-
     for key, value in runtime_config.items():
-        new_key = translation_map.get(key, key)
-        kwargs[new_key] = value
-
+        if key not in translation_map:
+            continue
+        kwargs[translation_map[key]] = value
     return TransferConfig(**kwargs)
diff --git a/tests/unit/customizations/s3/test_transferconfig.py b/tests/unit/customizations/s3/test_transferconfig.py
index 1a8717898dfe..2684af3e6de0 100644
--- a/tests/unit/customizations/s3/test_transferconfig.py
+++ b/tests/unit/customizations/s3/test_transferconfig.py
@@ -77,7 +77,12 @@ def test_convert(self):
             'multipart_threshold': 1,
             'multipart_chunksize': 2,
             'max_concurrent_requests': 3,
-            'max_queue_size': 4
+            'max_queue_size': 4,
+            'addressing_style': 'path',
+            'use_accelerate_endpoint': True,
+            # This is a TransferConfig only option, it should
+            # just be ignored if it's in the ~/.aws/config for now.
+            'max_in_memory_upload_chunks': 1000,
         }
         result = transferconfig.create_transfer_config_from_runtime_config(
             runtime_config)
@@ -85,3 +90,4 @@ def test_convert(self):
         self.assertEqual(result.multipart_chunksize, 2)
         self.assertEqual(result.max_request_concurrency, 3)
         self.assertEqual(result.max_request_queue_size, 4)
+        self.assertNotEqual(result.max_in_memory_upload_chunks, 1000)