DESCRIPTION

Package: LRTq
Type: Package
Title: Rare variant association test for quantitative traits with likelihood ratio test
Version: 1.0
Date: 2019-06-15
Author: Jiajin Li (Albert Lee)
Maintainer: Jiajin Li (Albert Lee) <lijj36@ucla.edu>
Description: LRTq, a powerful statistical method that infers causal statuses of rare variants with prior information and observational data and then aggregate rare variants in a nonlinear manner. With the assumption that individuals with abnormal gene expression levels are likely to enrich for causal rare variants, LRTq performs a likelihood ratio test to identify whether there are at least one causal rare variants in a group of variants near a gene. It first computes the ratio between the null model that assumes no causal rare variants in a variant set and the alternative model that asserts at least one causal rare variants. LRTq then calculates p-value for the likelihood ratio between these two models using permutation test.
License: MIT
Imports: Rcpp (>= 1.0.1)
LinkingTo: Rcpp