diff --git a/crates/uv-python/src/interpreter.rs b/crates/uv-python/src/interpreter.rs
index 30cdc37d37cf..4457f14cc6ad 100644
--- a/crates/uv-python/src/interpreter.rs
+++ b/crates/uv-python/src/interpreter.rs
@@ -616,7 +616,8 @@ impl InterpreterInfo {
             tempdir.path().escape_for_python()
         );
         let output = Command::new(interpreter)
-            .arg("-I")
+            .arg("-I") // Isolated mode.
+            .arg("-B") // Don't write bytecode.
             .arg("-c")
             .arg(script)
             .output()