diff --git a/internal/cli/arguments/profiles.go b/internal/cli/arguments/profiles.go
index 67253332582..6516cbdec08 100644
--- a/internal/cli/arguments/profiles.go
+++ b/internal/cli/arguments/profiles.go
@@ -27,7 +27,13 @@ type Profile struct {
 // AddToCommand adds the flags used to set fqbn to the specified Command
 func (f *Profile) AddToCommand(cmd *cobra.Command) {
 	cmd.Flags().StringVarP(&f.profile, "profile", "m", "", tr("Sketch profile to use"))
-	// TODO: register autocompletion
+	cmd.RegisterFlagCompletionFunc("profile", func(cmd *cobra.Command, args []string, toComplete string) ([]string, cobra.ShellCompDirective) {
+		var sketchProfile string
+		if len(args) > 0 {
+			sketchProfile = args[0]
+		}
+		return GetSketchProfiles(sketchProfile), cobra.ShellCompDirectiveDefault
+	})
 }
 
 // Get returns the profile name
diff --git a/internal/cli/arguments/sketch.go b/internal/cli/arguments/sketch.go
index 58df45e3367..9b43173e7db 100644
--- a/internal/cli/arguments/sketch.go
+++ b/internal/cli/arguments/sketch.go
@@ -16,8 +16,12 @@
 package arguments
 
 import (
+	"context"
+
+	"github.com/arduino/arduino-cli/commands/sketch"
 	sk "github.com/arduino/arduino-cli/commands/sketch"
 	"github.com/arduino/arduino-cli/internal/cli/feedback"
+	rpc "github.com/arduino/arduino-cli/rpc/cc/arduino/cli/commands/v1"
 	"github.com/arduino/go-paths-helper"
 	"github.com/sirupsen/logrus"
 )
@@ -43,3 +47,24 @@ func InitSketchPath(path string, printWarnings bool) (sketchPath *paths.Path) {
 	}
 	return sketchPath
 }
+
+// GetSketchProfiles is an helper function useful to autocomplete.
+// It returns the profile names set in the sketch.yaml
+func GetSketchProfiles(sketchPath string) []string {
+	if sketchPath == "" {
+		if wd, _ := paths.Getwd(); wd != nil && wd.String() != "" {
+			sketchPath = wd.String()
+		} else {
+			return nil
+		}
+	}
+	list, _ := sketch.LoadSketch(context.Background(), &rpc.LoadSketchRequest{
+		SketchPath: sketchPath,
+	})
+	profiles := list.GetProfiles()
+	res := make([]string, len(profiles))
+	for i, p := range list.GetProfiles() {
+		res[i] = p.GetName()
+	}
+	return res
+}
diff --git a/internal/integrationtest/completion/completion_test.go b/internal/integrationtest/completion/completion_test.go
index 75da997a357..a216eb0f6ff 100644
--- a/internal/integrationtest/completion/completion_test.go
+++ b/internal/integrationtest/completion/completion_test.go
@@ -19,6 +19,7 @@ import (
 	"testing"
 
 	"github.com/arduino/arduino-cli/internal/integrationtest"
+	"github.com/arduino/go-paths-helper"
 	"github.com/stretchr/testify/require"
 )
 
@@ -229,3 +230,30 @@ func TestCoreCompletion(t *testing.T) {
 	stdout, _, _ = cli.Run("__complete", "upload", "-P", "")
 	require.Contains(t, string(stdout), "atmel_ice")
 }
+
+func TestProfileCompletion(t *testing.T) {
+	env, cli := integrationtest.CreateArduinoCLIWithEnvironment(t)
+	defer env.CleanUp()
+
+	// Create test sketches
+	sketchWithProfilesPath, err := paths.New("testdata", "SketchWithProfiles").Abs()
+	require.NoError(t, err)
+	require.True(t, sketchWithProfilesPath.IsDir())
+
+	stdout, _, _ := cli.Run("__complete", "compile", sketchWithProfilesPath.String(), "--profile", "")
+	require.Contains(t, string(stdout), "profile1")
+	stdout, _, _ = cli.Run("__complete", "monitor", sketchWithProfilesPath.String(), "--profile", "")
+	require.Contains(t, string(stdout), "profile1")
+	stdout, _, _ = cli.Run("__complete", "upload", sketchWithProfilesPath.String(), "--profile", "")
+	require.Contains(t, string(stdout), "profile1")
+
+	// The cli is running in the sketch folder, so need the explictly specify the path in the cli
+	cli.SetWorkingDir(sketchWithProfilesPath)
+	stdout, _, _ = cli.Run("__complete", "compile", "--profile", "")
+	require.Contains(t, string(stdout), "profile1")
+	stdout, _, _ = cli.Run("__complete", "monitor", "--profile", "")
+	require.Contains(t, string(stdout), "profile1")
+	stdout, _, _ = cli.Run("__complete", "upload", "--profile", "")
+	require.Contains(t, string(stdout), "profile1")
+
+}
diff --git a/internal/integrationtest/completion/testdata/SketchWithProfiles/SketchWithProfiles.ino b/internal/integrationtest/completion/testdata/SketchWithProfiles/SketchWithProfiles.ino
new file mode 100644
index 00000000000..5054c040393
--- /dev/null
+++ b/internal/integrationtest/completion/testdata/SketchWithProfiles/SketchWithProfiles.ino
@@ -0,0 +1,3 @@
+
+void setup() {}
+void loop() {}
diff --git a/internal/integrationtest/completion/testdata/SketchWithProfiles/sketch.yaml b/internal/integrationtest/completion/testdata/SketchWithProfiles/sketch.yaml
new file mode 100644
index 00000000000..7143ea94b9a
--- /dev/null
+++ b/internal/integrationtest/completion/testdata/SketchWithProfiles/sketch.yaml
@@ -0,0 +1,5 @@
+default_port: /dev/ttyDEF
+default_fqbn: arduino:avr:yun
+profiles:
+  profile1:
+    fqbn: "arduino:avr:uno"