diff --git a/libraries/apollo-normalized-cache/src/commonMain/kotlin/com/apollographql/apollo3/cache/normalized/ApolloStore.kt b/libraries/apollo-normalized-cache/src/commonMain/kotlin/com/apollographql/apollo3/cache/normalized/ApolloStore.kt
index a94937349c2..e753cc72400 100644
--- a/libraries/apollo-normalized-cache/src/commonMain/kotlin/com/apollographql/apollo3/cache/normalized/ApolloStore.kt
+++ b/libraries/apollo-normalized-cache/src/commonMain/kotlin/com/apollographql/apollo3/cache/normalized/ApolloStore.kt
@@ -13,6 +13,7 @@ import com.apollographql.apollo3.cache.normalized.api.NormalizedCacheFactory
 import com.apollographql.apollo3.cache.normalized.api.Record
 import com.apollographql.apollo3.cache.normalized.api.TypePolicyCacheKeyGenerator
 import com.apollographql.apollo3.cache.normalized.internal.DefaultApolloStore
+import com.apollographql.apollo3.interceptor.ApolloInterceptor
 import com.benasher44.uuid.Uuid
 import kotlinx.coroutines.flow.SharedFlow
 import kotlin.reflect.KClass
@@ -265,3 +266,8 @@ fun ApolloStore(
     cacheKeyGenerator: CacheKeyGenerator = TypePolicyCacheKeyGenerator,
     cacheResolver: CacheResolver = FieldPolicyCacheResolver,
 ): ApolloStore = DefaultApolloStore(normalizedCacheFactory, cacheKeyGenerator, cacheResolver)
+
+/**
+ * Interface that marks all interceptors added when configuring a `store()` on ApolloClient.Builder.
+ */
+internal interface ApolloStoreInterceptor : ApolloInterceptor
diff --git a/libraries/apollo-normalized-cache/src/commonMain/kotlin/com/apollographql/apollo3/cache/normalized/ClientCacheExtensions.kt b/libraries/apollo-normalized-cache/src/commonMain/kotlin/com/apollographql/apollo3/cache/normalized/ClientCacheExtensions.kt
index 0e9729ff924..b84f541c2c8 100644
--- a/libraries/apollo-normalized-cache/src/commonMain/kotlin/com/apollographql/apollo3/cache/normalized/ClientCacheExtensions.kt
+++ b/libraries/apollo-normalized-cache/src/commonMain/kotlin/com/apollographql/apollo3/cache/normalized/ClientCacheExtensions.kt
@@ -122,6 +122,13 @@ fun ApolloClient.Builder.store(store: ApolloStore, writeToCacheAsynchronously: B
   check(interceptors.none { it is AutoPersistedQueryInterceptor }) {
     "Apollo: the normalized cache must be configured before the auto persisted queries"
   }
+  // Removing existing interceptors added for configuring an [ApolloStore].
+  // If a builder is reused from an existing client using `newBuilder()` and we try to configure a new `store()` on it, we first need to
+  // remove the old interceptors.
+  val storeInterceptors = interceptors.filterIsInstance<ApolloStoreInterceptor>()
+  storeInterceptors.forEach {
+    removeInterceptor(it)
+  }
   return addInterceptor(WatcherInterceptor(store))
       .addInterceptor(FetchPolicyRouterInterceptor)
       .addInterceptor(ApolloCacheInterceptor(store))
diff --git a/libraries/apollo-normalized-cache/src/commonMain/kotlin/com/apollographql/apollo3/cache/normalized/FetchPolicyInterceptors.kt b/libraries/apollo-normalized-cache/src/commonMain/kotlin/com/apollographql/apollo3/cache/normalized/FetchPolicyInterceptors.kt
index f94ba23994a..94ac5e6808e 100644
--- a/libraries/apollo-normalized-cache/src/commonMain/kotlin/com/apollographql/apollo3/cache/normalized/FetchPolicyInterceptors.kt
+++ b/libraries/apollo-normalized-cache/src/commonMain/kotlin/com/apollographql/apollo3/cache/normalized/FetchPolicyInterceptors.kt
@@ -129,7 +129,7 @@ val CacheAndNetworkInterceptor = object : ApolloInterceptor {
   }
 }
 
-internal object FetchPolicyRouterInterceptor : ApolloInterceptor {
+internal object FetchPolicyRouterInterceptor : ApolloInterceptor, ApolloStoreInterceptor {
   override fun <D : Operation.Data> intercept(request: ApolloRequest<D>, chain: ApolloInterceptorChain): Flow<ApolloResponse<D>> {
     if (request.operation !is Query) {
       // Subscriptions and Mutations do not support fetchPolicies
diff --git a/libraries/apollo-normalized-cache/src/commonMain/kotlin/com/apollographql/apollo3/cache/normalized/internal/ApolloCacheInterceptor.kt b/libraries/apollo-normalized-cache/src/commonMain/kotlin/com/apollographql/apollo3/cache/normalized/internal/ApolloCacheInterceptor.kt
index 0e14a50acd5..c6e0727863f 100644
--- a/libraries/apollo-normalized-cache/src/commonMain/kotlin/com/apollographql/apollo3/cache/normalized/internal/ApolloCacheInterceptor.kt
+++ b/libraries/apollo-normalized-cache/src/commonMain/kotlin/com/apollographql/apollo3/cache/normalized/internal/ApolloCacheInterceptor.kt
@@ -9,6 +9,7 @@ import com.apollographql.apollo3.api.Operation
 import com.apollographql.apollo3.api.Query
 import com.apollographql.apollo3.api.Subscription
 import com.apollographql.apollo3.cache.normalized.ApolloStore
+import com.apollographql.apollo3.cache.normalized.ApolloStoreInterceptor
 import com.apollographql.apollo3.cache.normalized.CacheInfo
 import com.apollographql.apollo3.cache.normalized.api.ApolloCacheHeaders
 import com.apollographql.apollo3.cache.normalized.api.CacheHeaders
@@ -36,7 +37,7 @@ import kotlinx.coroutines.launch
 
 internal class ApolloCacheInterceptor(
     val store: ApolloStore,
-) : ApolloInterceptor {
+) : ApolloInterceptor, ApolloStoreInterceptor {
   private suspend fun <D : Operation.Data> maybeAsync(request: ApolloRequest<D>, block: suspend () -> Unit) {
     if (request.writeToCacheAsynchronously) {
       val scope = request.executionContext[ConcurrencyInfo]!!.coroutineScope
diff --git a/libraries/apollo-normalized-cache/src/commonMain/kotlin/com/apollographql/apollo3/cache/normalized/internal/WatcherInterceptor.kt b/libraries/apollo-normalized-cache/src/commonMain/kotlin/com/apollographql/apollo3/cache/normalized/internal/WatcherInterceptor.kt
index 654eb5651c9..f2f0a3dd714 100644
--- a/libraries/apollo-normalized-cache/src/commonMain/kotlin/com/apollographql/apollo3/cache/normalized/internal/WatcherInterceptor.kt
+++ b/libraries/apollo-normalized-cache/src/commonMain/kotlin/com/apollographql/apollo3/cache/normalized/internal/WatcherInterceptor.kt
@@ -6,6 +6,7 @@ import com.apollographql.apollo3.api.CustomScalarAdapters
 import com.apollographql.apollo3.api.Operation
 import com.apollographql.apollo3.api.Query
 import com.apollographql.apollo3.cache.normalized.ApolloStore
+import com.apollographql.apollo3.cache.normalized.ApolloStoreInterceptor
 import com.apollographql.apollo3.cache.normalized.api.dependentKeys
 import com.apollographql.apollo3.cache.normalized.watchContext
 import com.apollographql.apollo3.exception.DefaultApolloException
@@ -23,7 +24,7 @@ import kotlinx.coroutines.flow.onSubscription
 
 internal val WatcherSentinel = DefaultApolloException("The watcher has started")
 
-internal class WatcherInterceptor(val store: ApolloStore) : ApolloInterceptor {
+internal class WatcherInterceptor(val store: ApolloStore) : ApolloInterceptor, ApolloStoreInterceptor {
   override fun <D : Operation.Data> intercept(request: ApolloRequest<D>, chain: ApolloInterceptorChain): Flow<ApolloResponse<D>> {
     val watchContext = request.watchContext ?: return chain.proceed(request)
 
diff --git a/libraries/apollo-runtime/src/commonMain/kotlin/com/apollographql/apollo3/ApolloClient.kt b/libraries/apollo-runtime/src/commonMain/kotlin/com/apollographql/apollo3/ApolloClient.kt
index d85e4fe4c7e..dc4f60e55ba 100644
--- a/libraries/apollo-runtime/src/commonMain/kotlin/com/apollographql/apollo3/ApolloClient.kt
+++ b/libraries/apollo-runtime/src/commonMain/kotlin/com/apollographql/apollo3/ApolloClient.kt
@@ -776,6 +776,15 @@ private constructor(
       _interceptors.add(interceptor)
     }
 
+    /**
+     * Removes an [ApolloInterceptor] from this [ApolloClient].
+     *
+     * **The order is important**. This method removes the first occurrence of the [ApolloInterceptor] in the list.
+     */
+    fun removeInterceptor(interceptor: ApolloInterceptor) = apply {
+      _interceptors.remove(interceptor)
+    }
+
     /**
      * Adds several [ApolloInterceptor]s to this [ApolloClient].
      *
diff --git a/tests/integration-tests/src/commonTest/kotlin/test/StoreTest.kt b/tests/integration-tests/src/commonTest/kotlin/test/StoreTest.kt
index 89d1317851c..8695cc0c693 100644
--- a/tests/integration-tests/src/commonTest/kotlin/test/StoreTest.kt
+++ b/tests/integration-tests/src/commonTest/kotlin/test/StoreTest.kt
@@ -120,6 +120,17 @@ class StoreTest {
     assertFriendIsNotCached("1003")
   }
 
+  @Test
+  fun testNewBuilderNewStore() = runTest(before = { setUp() }) {
+    storeAllFriends()
+    assertFriendIsCached("1000", "Luke Skywalker")
+
+    val newStore = ApolloStore(MemoryCacheFactory())
+    val newClient = apolloClient.newBuilder().store(newStore).build()
+
+    assertFriendIsNotCached("1000", newClient)
+  }
+
   private suspend fun storeAllFriends() {
     val query = HeroAndFriendsNamesWithIDsQuery(Episode.NEWHOPE)
     apolloClient.enqueueTestResponse(query, HeroAndFriendsNamesWithIDsQuery.Data(
@@ -158,9 +169,12 @@ class StoreTest {
     assertEquals2(characterResponse.data?.character?.name, name)
   }
 
-  private suspend fun assertFriendIsNotCached(id: String) {
+  private suspend fun assertFriendIsNotCached(
+      id: String,
+      apolloClientToUse: ApolloClient = apolloClient,
+  ) {
     assertIs<CacheMissException>(
-        apolloClient.query(CharacterNameByIdQuery(id))
+        apolloClientToUse.query(CharacterNameByIdQuery(id))
             .fetchPolicy(FetchPolicy.CacheOnly)
             .execute()
             .exception