diff --git a/cmake/modules/Micro.cmake b/cmake/modules/Micro.cmake
index da82cc9f4569..d887486d2e98 100644
--- a/cmake/modules/Micro.cmake
+++ b/cmake/modules/Micro.cmake
@@ -61,7 +61,7 @@ if(USE_MICRO)
         APPEND
         PLATFORM_FILE_COPY_JOBS
         "src/runtime/crt/host microtvm_api_server.py -> crt"
-        "src/runtime/crt/host Makefile.template -> crt"
+        "src/runtime/crt/host CMakeLists.txt.template -> crt"
         "src/runtime/crt/host **.cc -> crt/src"
       )
     else()
diff --git a/src/runtime/crt/host/CMakeLists.txt.template b/src/runtime/crt/host/CMakeLists.txt.template
new file mode 100644
index 000000000000..be0bce85513b
--- /dev/null
+++ b/src/runtime/crt/host/CMakeLists.txt.template
@@ -0,0 +1,59 @@
+# Licensed to the Apache Software Foundation (ASF) under one
+# or more contributor license agreements.  See the NOTICE file
+# distributed with this work for additional information
+# regarding copyright ownership.  The ASF licenses this file
+# to you under the Apache License, Version 2.0 (the
+# "License"); you may not use this file except in compliance
+# with the License.  You may obtain a copy of the License at
+#
+#   http://www.apache.org/licenses/LICENSE-2.0
+#
+# Unless required by applicable law or agreed to in writing,
+# software distributed under the License is distributed on an
+# "AS IS" BASIS, WITHOUT WARRANTIES OR CONDITIONS OF ANY
+# KIND, either express or implied.  See the License for the
+# specific language governing permissions and limitations
+# under the License.
+
+# SPDX-License-Identifier: Apache-2.0
+
+cmake_minimum_required(VERSION 3.18)
+set(CMAKE_CXX_STANDARD 11)
+
+project(crt_autogenerated_project C CXX)
+add_executable(main)
+
+set(CRT_LIB_BASE crt/src/runtime/crt)
+set(CRT_LIBS microtvm_rpc_server
+  microtvm_rpc_common
+  aot_executor_module
+  aot_executor
+  graph_executor_module
+  graph_executor
+  common
+  memory
+)
+
+# Build CRT libraries
+foreach(crt_lib_name ${CRT_LIBS})
+  add_library(${crt_lib_name})
+  file(GLOB_RECURSE crt_lib_srcs ${CRT_LIB_BASE}/${crt_lib_name}/*.c ${CRT_LIB_BASE}/${crt_lib_name}/*.cc)
+  target_sources(${crt_lib_name} PRIVATE ${crt_lib_srcs})
+  target_include_directories(${crt_lib_name} PRIVATE crt_config crt/include)
+  target_compile_definitions(${crt_lib_name} PRIVATE -DTVM_HOST_USE_GRAPH_EXECUTOR_MODULE)
+  target_link_libraries(main PRIVATE ${crt_lib_name})
+endforeach(crt_lib_name ${CRT_LIBS})
+
+# Build model files
+add_library(tvm_model)
+file(GLOB_RECURSE tvm_model_srcs model/codegen/host/src/*.c model/codegen/host/lib/*.o)
+target_sources(tvm_model PRIVATE ${tvm_model_srcs})
+target_include_directories(tvm_model PRIVATE ${CMAKE_SOURCE_DIR}/include crt_config crt/include)
+target_compile_options(tvm_model PRIVATE -Wno-error=unused-variable -Wno-error=missing-braces -Wno-error=unused-const-variable -Wno-unused-variable)
+set_target_properties(tvm_model PROPERTIES LINKER_LANGUAGE C)
+target_link_libraries(main PRIVATE tvm_model)
+
+file(GLOB_RECURSE app_srcs src/**.cc)
+target_sources(main PRIVATE ${app_srcs} ${cmsis_lib_srcs})
+target_compile_definitions(main PRIVATE -DTVM_HOST_USE_GRAPH_EXECUTOR_MODULE)
+target_include_directories(main PRIVATE crt_config include ${CMAKE_SOURCE_DIR}/include crt/include)
diff --git a/src/runtime/crt/host/Makefile.template b/src/runtime/crt/host/Makefile.template
deleted file mode 100644
index 526b17deb73f..000000000000
--- a/src/runtime/crt/host/Makefile.template
+++ /dev/null
@@ -1,87 +0,0 @@
-# Licensed to the Apache Software Foundation (ASF) under one
-# or more contributor license agreements.  See the NOTICE file
-# distributed with this work for additional information
-# regarding copyright ownership.  The ASF licenses this file
-# to you under the Apache License, Version 2.0 (the
-# "License"); you may not use this file except in compliance
-# with the License.  You may obtain a copy of the License at
-#
-#   http://www.apache.org/licenses/LICENSE-2.0
-#
-# Unless required by applicable law or agreed to in writing,
-# software distributed under the License is distributed on an
-# "AS IS" BASIS, WITHOUT WARRANTIES OR CONDITIONS OF ANY
-# KIND, either express or implied.  See the License for the
-# specific language governing permissions and limitations
-# under the License.
-
-INCLUDES ?= -isystem crt/include -Icrt_config
-TVM_WORKSPACE_SIZE_BYTES := <TVM_WORKSPACE_SIZE_BYTES>
-CFLAGS ?= -Werror -Wall
-CXXFLAGS ?= -Werror -Wall -std=c++11 -DTVM_HOST_USE_GRAPH_EXECUTOR_MODULE -DTVM_WORKSPACE_SIZE_BYTES=$(TVM_WORKSPACE_SIZE_BYTES)
-LDFLAGS ?= -Werror -Wall
-
-# Codegen produces spurious lines like: int32_t arg2_code = ((int32_t*)arg_type_ids)[(2)];
-MODEL_CFLAGS ?= -Wno-error=unused-variable -Wno-error=missing-braces -Wno-error=unused-const-variable -Wno-unused-variable
-
-AR ?= ${PREFIX}ar
-CC ?= ${PREFIX}gcc
-CXX ?= ${PREFIX}g++
-RANLIB ?= ${PREFIX}ranlib
-
-ifeq (${VERBOSE}, 1)
-QUIET ?=
-else
-QUIET ?= @
-endif
-
-PWD = $(shell pwd)
-BUILD_DIR = build
-
-CRT_LIB_NAMES = \
-	microtvm_rpc_server microtvm_rpc_common \
-	aot_executor_module aot_executor \
-	graph_executor_module graph_executor \
-	common memory
-
-CRT_LIBS = $(patsubst %, $(BUILD_DIR)/crt/lib%.a, $(CRT_LIB_NAMES))
-
-CRT_INCLUDES = $(glob crt/include/**)
-
-$(BUILD_DIR)/crt/lib%.a: $(glob crt/src/runtime/%/*.c)
-	${QUIET}cd crt && $(MAKE) -s \
-		BUILD_DIR=../$(BUILD_DIR)/crt \
-		CRT_CONFIG=$(PWD)/crt_config/crt_config.h \
-		EXTRA_CFLAGS="$(CFLAGS)" \
-		EXTRA_CXXFLAGS="$(CXXFLAGS)" \
-		EXTRA_LDFLAGS="$(EXTRA_LDFLAGS)" \
-		$(patsubst $(BUILD_DIR)/crt/lib%.a,%,$@)
-
-crt: $(CRT_LIBS)
-.PHONY: crt
-
-# Compile codegen files
-$(BUILD_DIR)/model/codegen/host/%.o: model/codegen/host/%.c
-	${QUIET}mkdir -p $(dir $@)
-	${QUIET}$(CC) $(INCLUDES) $(CFLAGS) $(MODEL_CFLAGS) -c -o "$@" "$<"
-
-MODEL_LIBS = \
-	$(patsubst model/codegen/host/src/%.c, $(BUILD_DIR)/model/codegen/host/src/%.o, $(wildcard model/codegen/host/src/*.c)) \
-	$(wildcard model/codegen/host/lib/*.o)
-
-# Compile src/ files
-build/%.o: src/%.cc
-	${QUIET}mkdir -p $(dir $@)
-	${QUIET}$(CXX) $(INCLUDES) $(CXXFLAGS) -c -o "$@" "$<"
-
-SRCS = $(wildcard src/*.cc)
-OBJS = $(patsubst src/%.cc,build/%.o,$(SRCS))
-
-build/main: ${OBJS} ${MODEL_LIBS} ${CRT_LIBS}
-	${QUIET}mkdir -p $(dir $@)
-	${QUIET}$(CXX) $(LDFLAGS) -o "$@" $^
-
-all: build/main
-.PHONY = all
-
-.DEFAULT_GOAL = all
diff --git a/src/runtime/crt/host/microtvm_api_server.py b/src/runtime/crt/host/microtvm_api_server.py
index 9887cb6e0474..af6947a18b9c 100644
--- a/src/runtime/crt/host/microtvm_api_server.py
+++ b/src/runtime/crt/host/microtvm_api_server.py
@@ -40,11 +40,13 @@
 # Used this size to pass most CRT tests in TVM.
 WORKSPACE_SIZE_BYTES = 2 * 1024 * 1024
 
-MAKEFILE_FILENAME = "Makefile"
+CMAKEFILE_FILENAME = "CMakeLists.txt"
 
+# The build target given to make
+BUILD_TARGET = "build/main"
 
-class Handler(server.ProjectAPIHandler):
 
+class Handler(server.ProjectAPIHandler):
     BUILD_TARGET = "build/main"
 
     def __init__(self):
@@ -79,29 +81,25 @@ def server_info_query(self, tvm_version):
     # These files and directories will be recursively copied into generated projects from the CRT.
     CRT_COPY_ITEMS = ("include", "Makefile", "src")
 
-    # The build target given to make
-    BUILD_TARGET = "build/main"
-
-    def _populate_makefile(
+    def _populate_cmake(
         self,
-        makefile_template_path: pathlib.Path,
-        makefile_path: pathlib.Path,
+        cmakefile_template_path: pathlib.Path,
+        cmakefile_path: pathlib.Path,
         memory_size: int,
+        verbose: bool,
     ):
-        """Generate Makefile from template."""
-        flags = {
-            "TVM_WORKSPACE_SIZE_BYTES": str(memory_size),
-        }
+        """Generate CMakeList file from template."""
 
         regex = re.compile(r"([A-Z_]+) := (<[A-Z_]+>)")
-        with open(makefile_path, "w") as makefile_f:
-            with open(makefile_template_path, "r") as makefile_template_f:
-                for line in makefile_template_f:
-                    m = regex.match(line)
-                    if m:
-                        var, token = m.groups()
-                        line = line.replace(token, flags[var])
-                    makefile_f.write(line)
+        with open(cmakefile_path, "w") as cmakefile_f:
+            with open(cmakefile_template_path, "r") as cmakefile_template_f:
+                for line in cmakefile_template_f:
+                    cmakefile_f.write(line)
+                cmakefile_f.write(
+                    f"target_compile_definitions(main PUBLIC -DTVM_WORKSPACE_SIZE_BYTES={memory_size})\n"
+                )
+                if verbose:
+                    cmakefile_f.write(f"set(CMAKE_VERBOSE_MAKEFILE TRUE)\n")
 
     def generate_project(self, model_library_format_path, standalone_crt_dir, project_dir, options):
         # Make project directory.
@@ -134,11 +132,12 @@ def generate_project(self, model_library_format_path, standalone_crt_dir, projec
             else:
                 shutil.copy2(src_path, dst_path)
 
-        # Populate Makefile
-        self._populate_makefile(
-            current_dir / f"{MAKEFILE_FILENAME}.template",
-            project_dir / MAKEFILE_FILENAME,
+        # Populate CMake file
+        self._populate_cmake(
+            current_dir / f"{CMAKEFILE_FILENAME}.template",
+            project_dir / CMAKEFILE_FILENAME,
             options.get("workspace_size_bytes", WORKSPACE_SIZE_BYTES),
+            options.get("verbose"),
         )
 
         # Populate crt-config.h
@@ -162,13 +161,10 @@ def generate_project(self, model_library_format_path, standalone_crt_dir, projec
         )
 
     def build(self, options):
-        args = ["make"]
-        if options.get("verbose"):
-            args.append("VERBOSE=1")
-
-        args.append(self.BUILD_TARGET)
-
-        subprocess.check_call(args, cwd=PROJECT_DIR)
+        build_dir = PROJECT_DIR / "build"
+        build_dir.mkdir()
+        subprocess.check_call(["cmake", ".."], cwd=build_dir)
+        subprocess.check_call(["make"], cwd=build_dir)
 
     def flash(self, options):
         pass  # Flashing does nothing on host.
diff --git a/tests/lint/check_file_type.py b/tests/lint/check_file_type.py
index f5f83f26cd16..56f812c867f4 100644
--- a/tests/lint/check_file_type.py
+++ b/tests/lint/check_file_type.py
@@ -157,7 +157,7 @@
     "apps/microtvm/arduino/template_project/Makefile.template",
     # microTVM CRT
     "src/runtime/crt/crt_config.h.template",
-    "src/runtime/crt/host/Makefile.template",
+    "src/runtime/crt/host/CMakeLists.txt.template",
     # microTVM Virtual Machines
     "apps/microtvm/poetry.lock",
     "apps/microtvm/reference-vm/Vagrantfile",