diff --git a/common/utils/src/main/resources/error/error-conditions.json b/common/utils/src/main/resources/error/error-conditions.json
index 975536c076ddb..4d291784899bd 100644
--- a/common/utils/src/main/resources/error/error-conditions.json
+++ b/common/utils/src/main/resources/error/error-conditions.json
@@ -4476,6 +4476,11 @@
           "INSERT INTO <tableName> with IF NOT EXISTS in the PARTITION spec."
         ]
       },
+      "LAMBDA_FUNCTION_WITH_PYTHON_UDF" : {
+        "message" : [
+          "Lambda function with Python UDF <funcName> in a higher order function."
+        ]
+      },
       "LATERAL_COLUMN_ALIAS_IN_AGGREGATE_FUNC" : {
         "message" : [
           "Referencing a lateral column alias <lca> in the aggregate function <aggFunc>."
diff --git a/sql/catalyst/src/main/scala/org/apache/spark/sql/catalyst/analysis/CheckAnalysis.scala b/sql/catalyst/src/main/scala/org/apache/spark/sql/catalyst/analysis/CheckAnalysis.scala
index bd8f8fe9f6528..9f3eee5198a16 100644
--- a/sql/catalyst/src/main/scala/org/apache/spark/sql/catalyst/analysis/CheckAnalysis.scala
+++ b/sql/catalyst/src/main/scala/org/apache/spark/sql/catalyst/analysis/CheckAnalysis.scala
@@ -254,6 +254,14 @@ trait CheckAnalysis extends PredicateHelper with LookupCatalog with QueryErrorsB
                 hof.invalidFormat(checkRes)
             }
 
+          case hof: HigherOrderFunction
+              if hof.resolved && hof.functions
+                .exists(_.exists(_.isInstanceOf[PythonUDF])) =>
+            val u = hof.functions.flatMap(_.find(_.isInstanceOf[PythonUDF])).head
+            hof.failAnalysis(
+              errorClass = "UNSUPPORTED_FEATURE.LAMBDA_FUNCTION_WITH_PYTHON_UDF",
+              messageParameters = Map("funcName" -> toSQLExpr(u)))
+
           // If an attribute can't be resolved as a map key of string type, either the key should be
           // surrounded with single quotes, or there is a typo in the attribute name.
           case GetMapValue(map, key: Attribute) if isMapWithStringKey(map) && !key.resolved =>
diff --git a/sql/core/src/test/scala/org/apache/spark/sql/execution/python/PythonUDFSuite.scala b/sql/core/src/test/scala/org/apache/spark/sql/execution/python/PythonUDFSuite.scala
index 3101281251b1b..2e56ad0ab4160 100644
--- a/sql/core/src/test/scala/org/apache/spark/sql/execution/python/PythonUDFSuite.scala
+++ b/sql/core/src/test/scala/org/apache/spark/sql/execution/python/PythonUDFSuite.scala
@@ -17,8 +17,8 @@
 
 package org.apache.spark.sql.execution.python
 
-import org.apache.spark.sql.{IntegratedUDFTestUtils, QueryTest}
-import org.apache.spark.sql.functions.count
+import org.apache.spark.sql.{AnalysisException, IntegratedUDFTestUtils, QueryTest}
+import org.apache.spark.sql.functions.{array, count, transform}
 import org.apache.spark.sql.test.SharedSparkSession
 import org.apache.spark.sql.types.LongType
 
@@ -112,4 +112,16 @@ class PythonUDFSuite extends QueryTest with SharedSparkSession {
     val pandasTestUDF = TestGroupedAggPandasUDF(name = udfName)
     assert(df.agg(pandasTestUDF(df("id"))).schema.fieldNames.exists(_.startsWith(udfName)))
   }
+
+  test("SPARK-48706: Negative test case for Python UDF in higher order functions") {
+    assume(shouldTestPythonUDFs)
+    checkError(
+      exception = intercept[AnalysisException] {
+        spark.range(1).select(transform(array("id"), x => pythonTestUDF(x))).collect()
+      },
+      errorClass = "UNSUPPORTED_FEATURE.LAMBDA_FUNCTION_WITH_PYTHON_UDF",
+      parameters = Map("funcName" -> "\"pyUDF(namedlambdavariable())\""),
+      context = ExpectedContext(
+        "transform", s".*${this.getClass.getSimpleName}.*"))
+  }
 }