diff --git a/setup.py b/setup.py
index 911d5f8ee078a..13197da7320ba 100644
--- a/setup.py
+++ b/setup.py
@@ -250,11 +250,10 @@ def write_version(filename: str = os.path.join(*[my_dir, "airflow", "git_version
 ]
 doc = [
     'click>=7.1,<9',
-    # Sphinx is limited to < 3.5.0 because of https://github.com/sphinx-doc/sphinx/issues/8880
-    'sphinx>=3.5.0, <5.0.0',
+    'sphinx>=4.0.0, <5.0.0',
     'sphinx-airflow-theme',
     'sphinx-argparse>=0.1.13',
-    'sphinx-autoapi==1.8.0',
+    'sphinx-autoapi~=1.8.0',
     'sphinx-copybutton',
     'sphinx-jinja~=1.1',
     'sphinx-rtd-theme>=0.1.6',