diff --git a/__tests__/integration/snapshots/tooltip/points-point-regression-quad/step0.html b/__tests__/integration/snapshots/tooltip/points-point-regression-quad/step0.html
new file mode 100644
index 0000000000..ec747fa47d
--- /dev/null
+++ b/__tests__/integration/snapshots/tooltip/points-point-regression-quad/step0.html
@@ -0,0 +1 @@
+null
\ No newline at end of file
diff --git a/__tests__/plots/tooltip/index.ts b/__tests__/plots/tooltip/index.ts
index 0ad22b7b14..47fb59ed52 100644
--- a/__tests__/plots/tooltip/index.ts
+++ b/__tests__/plots/tooltip/index.ts
@@ -60,3 +60,4 @@ export { aaplAreaMissingDataTranspose } from './aapl-area-missing-data-transpose
 export { alphabetIntervalBrushTooltip } from './alphabet-interval-brush-tooltip';
 export { mockLineFalsy } from './mock-line-falsy';
 export { provincesLineGroupName } from './provinces-line-group-name';
+export { pointsPointRegressionQuad } from './points-point-regression-quad';
diff --git a/__tests__/plots/tooltip/points-point-regression-quad.ts b/__tests__/plots/tooltip/points-point-regression-quad.ts
new file mode 100644
index 0000000000..95a3fdbae4
--- /dev/null
+++ b/__tests__/plots/tooltip/points-point-regression-quad.ts
@@ -0,0 +1,42 @@
+import { regressionQuad } from 'd3-regression';
+import { G2Spec } from '../../../src';
+import { points } from '../../data/points';
+import { seriesTooltipSteps } from './utils';
+
+const regression = regressionQuad()
+  .x((d) => d.x)
+  // @ts-ignore
+  .y((d) => d.y)
+  .domain([-4, 4]);
+
+export function pointsPointRegressionQuad(): G2Spec {
+  return {
+    type: 'view',
+    data: points,
+    scale: { x: { domain: [-4, 4] }, y: { domain: [-2, 14] } },
+    axis: { x: { title: false }, y: { title: false } },
+    children: [
+      {
+        type: 'point',
+        encode: { x: 'x', y: 'y', shape: 'point' },
+      },
+      {
+        type: 'line',
+        data: { transform: [{ type: 'custom', callback: regression }] },
+        encode: {
+          x: (d) => d[0],
+          y: (d) => d[1],
+        },
+        style: {
+          stroke: '#30BF78',
+          lineWidth: 2,
+        },
+        tooltip: false,
+      },
+      { type: 'lineX', data: [0] },
+      { type: 'lineY', data: [0] },
+    ],
+  };
+}
+
+pointsPointRegressionQuad.steps = seriesTooltipSteps([100, 300]);
diff --git a/site/examples/analysis/regression/demo/exponential-regression.ts b/site/examples/analysis/regression/demo/exponential-regression.ts
index d8de519f02..e949f01750 100644
--- a/site/examples/analysis/regression/demo/exponential-regression.ts
+++ b/site/examples/analysis/regression/demo/exponential-regression.ts
@@ -46,6 +46,7 @@ chart
     style: {
       textAlign: 'end',
     },
-  });
+  })
+  .tooltip(false);
 
 chart.render();
diff --git a/site/examples/analysis/regression/demo/linear-regression.ts b/site/examples/analysis/regression/demo/linear-regression.ts
index 09db7ec006..823475448b 100644
--- a/site/examples/analysis/regression/demo/linear-regression.ts
+++ b/site/examples/analysis/regression/demo/linear-regression.ts
@@ -49,6 +49,4 @@ chart
   })
   .tooltip(false);
 
-chart.interaction('tooltip', { series: false });
-
 chart.render();
diff --git a/site/examples/analysis/regression/demo/logarithmic-regression.ts b/site/examples/analysis/regression/demo/logarithmic-regression.ts
index 67a80b2018..ba7d99c884 100644
--- a/site/examples/analysis/regression/demo/logarithmic-regression.ts
+++ b/site/examples/analysis/regression/demo/logarithmic-regression.ts
@@ -48,6 +48,7 @@ chart
     style: {
       textAlign: 'end',
     },
-  });
+  })
+  .tooltip(false);
 
 chart.render();
diff --git a/site/examples/analysis/regression/demo/polynomial-regression.ts b/site/examples/analysis/regression/demo/polynomial-regression.ts
index e24c662e1f..207ca6c9a4 100644
--- a/site/examples/analysis/regression/demo/polynomial-regression.ts
+++ b/site/examples/analysis/regression/demo/polynomial-regression.ts
@@ -56,6 +56,7 @@ chart
       textAlign: 'end',
       dx: -8,
     },
-  });
+  })
+  .tooltip(null);
 
 chart.render();
diff --git a/site/examples/analysis/regression/demo/quadratic-regression.ts b/site/examples/analysis/regression/demo/quadratic-regression.ts
index 1e25b14203..97391142c2 100644
--- a/site/examples/analysis/regression/demo/quadratic-regression.ts
+++ b/site/examples/analysis/regression/demo/quadratic-regression.ts
@@ -49,7 +49,8 @@ chart
   .encode('x', (d) => d[0])
   .encode('y', (d) => d[1])
   .style('stroke', '#30BF78')
-  .style('lineWidth', 2);
+  .style('lineWidth', 2)
+  .tooltip(false);
 
 chart.lineX().data([0]);
 chart.lineY().data([0]);
diff --git a/src/interaction/tooltip.ts b/src/interaction/tooltip.ts
index 31bc817b1e..3dd43bb17d 100644
--- a/src/interaction/tooltip.ts
+++ b/src/interaction/tooltip.ts
@@ -279,6 +279,13 @@ function isEmptyTooltipData(data) {
   return false;
 }
 
+function hasSeries(markState): boolean {
+  return Array.from(markState.values()).some(
+    // @ts-ignore
+    (d) => d.interaction?.seriesTooltip && d.tooltip,
+  );
+}
+
 /**
  * Show tooltip for series item.
  */
@@ -599,7 +606,6 @@ export function Tooltip(options) {
   return (target, viewInstances) => {
     const { container, view } = target;
     const { scale, markState, coordinate } = view;
-
     // Get default value from mark states.
     const defaultSeries = interactionKeyof(markState, 'seriesTooltip');
     const defaultShowCrosshairs = interactionKeyof(markState, 'crosshairs');
@@ -607,7 +613,7 @@ export function Tooltip(options) {
     const isSeries = maybeValue(series, defaultSeries);
 
     // For non-facet and series tooltip.
-    if (isSeries && !facet) {
+    if (isSeries && hasSeries(markState) && !facet) {
       return seriesTooltip(plotArea, {
         ...rest,
         elements: selectG2Elements,