diff --git a/__tests__/integration/api-chart-render-clear-interaction.spec.ts b/__tests__/integration/api-chart-render-clear-interaction.spec.ts
new file mode 100644
index 0000000000..4196c9672c
--- /dev/null
+++ b/__tests__/integration/api-chart-render-clear-interaction.spec.ts
@@ -0,0 +1,35 @@
+import { CustomEvent as GCustomEvent } from '@antv/g';
+import { chartRenderClearInteraction as render } from '../plots/api/chart-render-clear-interaction';
+import { PLOT_CLASS_NAME } from '../../src';
+import { createDOMGCanvas } from './utils/createDOMGCanvas';
+import './utils/useSnapshotMatchers';
+import './utils/useCustomFetch';
+
+describe('chart.render', () => {
+  const dir = `${__dirname}/snapshots/api`;
+  const canvas = createDOMGCanvas(640, 480);
+
+  it('chart.interaction(name, false) should clear interaction.', async () => {
+    const { finished } = render({
+      canvas,
+      container: document.createElement('div'),
+    });
+    await finished;
+
+    // Trigger tooltip
+    const plot = canvas.document.getElementsByClassName(PLOT_CLASS_NAME)[0];
+    plot.dispatchEvent(
+      new GCustomEvent('pointermove', {
+        offsetX: 200,
+        offsetY: 300,
+      }),
+    );
+    await expect(canvas).toMatchDOMSnapshot(dir, render.name, {
+      selector: '.g2-tooltip',
+    });
+  });
+
+  afterAll(() => {
+    canvas?.destroy();
+  });
+});
diff --git a/__tests__/integration/snapshots/api/chartRenderClearInteraction.html b/__tests__/integration/snapshots/api/chartRenderClearInteraction.html
new file mode 100644
index 0000000000..ec747fa47d
--- /dev/null
+++ b/__tests__/integration/snapshots/api/chartRenderClearInteraction.html
@@ -0,0 +1 @@
+null
\ No newline at end of file
diff --git a/__tests__/plots/api/chart-render-clear-interaction.ts b/__tests__/plots/api/chart-render-clear-interaction.ts
new file mode 100644
index 0000000000..10552fcafc
--- /dev/null
+++ b/__tests__/plots/api/chart-render-clear-interaction.ts
@@ -0,0 +1,31 @@
+import { Chart } from '../../../src';
+
+export function chartRenderClearInteraction(context) {
+  const { container, canvas } = context;
+
+  const chart = new Chart({
+    container,
+    canvas,
+  });
+
+  chart.options({
+    theme: 'classic',
+    type: 'line',
+    clip: true,
+    data: {
+      type: 'fetch',
+      value: 'data/aapl.csv',
+    },
+    encode: {
+      x: 'date',
+      y: 'close',
+    },
+  });
+
+  const finished = chart.render().then(() => {
+    chart.options({ interaction: { tooltip: false } });
+    return chart.render();
+  });
+
+  return { chart, finished };
+}
diff --git a/src/runtime/plot.ts b/src/runtime/plot.ts
index bbf145a649..91069cd93c 100644
--- a/src/runtime/plot.ts
+++ b/src/runtime/plot.ts
@@ -230,10 +230,17 @@ export async function plot<T extends G2ViewTree>(
     target.container['nameInteraction'] = nameInteraction;
 
     // Apply interactions.
-    for (const option of inferInteraction(options)) {
-      const interaction = useInteraction(option);
-      const destroy = interaction(target, enterViewInstances, context.emitter);
-      nameInteraction.set(option.type, { destroy });
+    for (const typeOption of inferInteraction(options)) {
+      const [type, option] = typeOption;
+      if (option) {
+        const interaction = useInteraction({ type, ...(option as any) });
+        const destroy = interaction(
+          target,
+          enterViewInstances,
+          context.emitter,
+        );
+        nameInteraction.set(type, { destroy });
+      }
     }
   }
 
@@ -242,15 +249,23 @@ export async function plot<T extends G2ViewTree>(
   for (const target of updateViewInstances) {
     const { options, container } = target;
     const nameInteraction = container['nameInteraction'];
-    for (const option of inferInteraction(options)) {
+    for (const typeOption of inferInteraction(options)) {
+      const [type, option] = typeOption;
+
       // Remove interaction for existed views.
-      const prevInteraction = nameInteraction.get(option.type);
+      const prevInteraction = nameInteraction.get(type);
       if (prevInteraction) prevInteraction.destroy?.();
 
       // Apply new interaction.
-      const interaction = useInteraction(option);
-      const destroy = interaction(target, updateViewInstances, context.emitter);
-      nameInteraction.set(option.type, { destroy });
+      if (option) {
+        const interaction = useInteraction({ type, ...(option as any) });
+        const destroy = interaction(
+          target,
+          updateViewInstances,
+          context.emitter,
+        );
+        nameInteraction.set(type, { destroy });
+      }
     }
   }
 
@@ -314,7 +329,13 @@ function createUpdateView(
   };
 }
 
-function updateTooltip(selection, options, view, library, context) {
+function updateTooltip(
+  selection: Selection,
+  options: G2ViewTree,
+  view: G2ViewDescriptor,
+  library: G2Library,
+  context: G2Context,
+) {
   const [useInteraction] = useLibrary<
     G2InteractionOptions,
     InteractionComponent,
@@ -325,7 +346,7 @@ function updateTooltip(selection, options, view, library, context) {
   const container = selection.node();
   const nameInteraction = container['nameInteraction'];
   const tooltipOptions = inferInteraction(options).find(
-    (d) => d.type === 'tooltip',
+    ([d]) => d === 'tooltip',
   );
 
   // Destroy older tooltip.
@@ -333,8 +354,13 @@ function updateTooltip(selection, options, view, library, context) {
   if (!tooltip) return;
   tooltip.destroy?.();
 
+  if (!tooltipOptions[1]) return;
+
   // Apply new tooltip interaction.
-  const applyTooltip = useInteraction(tooltipOptions);
+  const applyTooltip = useInteraction({
+    type: 'tooltip',
+    ...(tooltipOptions[1] as any),
+  });
   const target = {
     options,
     view,
@@ -1351,7 +1377,9 @@ function inferTheme(theme: G2ThemeOptions = {}): G2ThemeOptions {
 /**
  * @todo Infer builtin tooltips.
  */
-function inferInteraction(view: G2View): G2InteractionOptions[] {
+function inferInteraction(
+  view: G2View,
+): [string, boolean | Omit<G2InteractionOptions, 'type'>][] {
   const defaults = {
     event: true,
     tooltip: true,
@@ -1360,12 +1388,7 @@ function inferInteraction(view: G2View): G2InteractionOptions[] {
     legendFilter: true,
   };
   const { interaction = {} } = view;
-  return Object.entries(deepMix(defaults, interaction))
-    .filter((d) => !!d[1])
-    .map(([key, value]) => ({
-      type: key,
-      ...(value as Record<string, any>),
-    }));
+  return Object.entries(deepMix(defaults, interaction));
 }
 
 async function applyTransform<T extends G2ViewTree>(