diff --git a/changelogs/fragments/601-ec2_vpc_route_table-ipv6-support.yml b/changelogs/fragments/601-ec2_vpc_route_table-ipv6-support.yml
new file mode 100644
index 00000000000..59a286c7041
--- /dev/null
+++ b/changelogs/fragments/601-ec2_vpc_route_table-ipv6-support.yml
@@ -0,0 +1,2 @@
+minor_changes:
+- ec2_vpc_route_table - add support for IPv6 in creating route tables (https://github.com/ansible-collections/amazon.aws/pull/601).
diff --git a/plugins/modules/ec2_vpc_route_table.py b/plugins/modules/ec2_vpc_route_table.py
index fa4005eb521..55f362194e3 100644
--- a/plugins/modules/ec2_vpc_route_table.py
+++ b/plugins/modules/ec2_vpc_route_table.py
@@ -226,6 +226,7 @@
 
 import re
 from time import sleep
+from ipaddress import ip_network
 
 try:
     import botocore
@@ -408,7 +409,7 @@ def ensure_routes(connection=None, module=None, route_table=None, route_specs=No
     for route_spec in route_specs:
         match = index_of_matching_route(route_spec, routes_to_match)
         if match is None:
-            if route_spec.get('DestinationCidrBlock'):
+            if route_spec.get('DestinationCidrBlock') or route_spec.get('DestinationIpv6CidrBlock'):
                 route_specs_to_create.append(route_spec)
             else:
                 module.warn("Skipping creating {0} because it has no destination cidr block. "
@@ -588,9 +589,13 @@ def get_route_table_info(connection, module, route_table):
 
 def create_route_spec(connection, module, vpc_id):
     routes = module.params.get('routes')
-
     for route_spec in routes:
-        rename_key(route_spec, 'dest', 'destination_cidr_block')
+
+        cidr_block_type = str(type(ip_network(route_spec['dest'])))
+        if "IPv4" in cidr_block_type:
+            rename_key(route_spec, 'dest', 'destination_cidr_block')
+        if "IPv6" in cidr_block_type:
+            rename_key(route_spec, 'dest', 'destination_ipv6_cidr_block')
 
         if route_spec.get('gateway_id') and route_spec['gateway_id'].lower() == 'igw':
             igw = find_igw(connection, module, vpc_id)
diff --git a/tests/integration/targets/ec2_vpc_route_table/tasks/main.yml b/tests/integration/targets/ec2_vpc_route_table/tasks/main.yml
index 2095c589163..f161ce24ab1 100644
--- a/tests/integration/targets/ec2_vpc_route_table/tasks/main.yml
+++ b/tests/integration/targets/ec2_vpc_route_table/tasks/main.yml
@@ -131,6 +131,8 @@
       routes:
       - dest: 0.0.0.0/0
         gateway_id: igw
+      - dest: ::/0
+        gateway_id: igw
     check_mode: true
     register: check_mode_results
   - name: assert a route would be added
@@ -147,16 +149,18 @@
       routes:
       - dest: 0.0.0.0/0
         gateway_id: igw
+      - dest: ::/0
+        gateway_id: igw
     register: add_routes
   - name: assert route table contains new route
     assert:
       that:
       - add_routes.changed
-      - add_routes.route_table.routes|length == 2
+      - add_routes.route_table.routes|length == 3
       - add_routes.route_table.id.startswith('rtb-')
       - "'Public' in add_routes.route_table.tags and add_routes.route_table.tags['Public']\
         \ == 'true'"
-      - add_routes.route_table.routes|length == 2
+      - add_routes.route_table.routes|length == 3
       - add_routes.route_table.associations|length == 0
       - add_routes.route_table.vpc_id == "{{ vpc.vpc.id }}"
       - add_routes.route_table.propagating_vgws|length == 0
@@ -191,7 +195,7 @@
     assert:
       that:
       - add_routes is not changed
-      - add_routes.route_table.routes|length == 2
+      - add_routes.route_table.routes|length == 3
 
   - name: CHECK MODE - add subnets to public route table
     ec2_vpc_route_table:
@@ -265,7 +269,7 @@
     assert:
       that:
       - not no_purge_routes.changed
-      - no_purge_routes.route_table.routes|length == 2
+      - no_purge_routes.route_table.routes|length == 3
       - no_purge_routes.route_table.associations|length == 2
 
   - name: rerun with purge_subnets set to false
@@ -283,7 +287,7 @@
     assert:
       that:
       - not no_purge_subnets.changed
-      - no_purge_subnets.route_table.routes|length == 2
+      - no_purge_subnets.route_table.routes|length == 3
       - no_purge_subnets.route_table.associations|length == 2
 
   - name: rerun with purge_tags not set (implicitly false)
@@ -428,7 +432,7 @@
     assert:
       that:
       - purge_routes.changed
-      - purge_routes.route_table.routes|length == 1
+      - purge_routes.route_table.routes|length == 2
       - purge_routes.route_table.id == create_public_table.route_table.id
 
   - name: CHECK MODE - update tags