diff --git a/src/node.cc b/src/node.cc
index 7c9032bf02945b..4386d372b7460c 100644
--- a/src/node.cc
+++ b/src/node.cc
@@ -3384,6 +3384,10 @@ inline void PlatformInit() {
   RegisterSignalHandler(SIGINT, SignalExit, true);
   RegisterSignalHandler(SIGTERM, SignalExit, true);
 
+  // Block SIGPROF signals when sleeping in epoll_wait/kevent/etc.  Avoids the
+  // performance penalty of frequent EINTR wakeups when the profiler is running.
+  uv_loop_configure(uv_default_loop(), UV_LOOP_BLOCK_SIGNAL, SIGPROF);
+
   // Raise the open file descriptor limit.
   struct rlimit lim;
   if (getrlimit(RLIMIT_NOFILE, &lim) == 0 && lim.rlim_cur != lim.rlim_max) {