diff --git a/conda/recipes/cugraph/meta.yaml b/conda/recipes/cugraph/meta.yaml
index b66e43e16a3..cfa9d80b993 100644
--- a/conda/recipes/cugraph/meta.yaml
+++ b/conda/recipes/cugraph/meta.yaml
@@ -69,7 +69,6 @@ requirements:
     - raft-dask ={{ minor_version }}
     - rmm ={{ minor_version }}
     - scikit-build-core >=0.7.0
-    - setuptools
   run:
     - aiohttp
     - {{ pin_compatible('cuda-version', max_pin='x', min_pin='x') }}
diff --git a/conda/recipes/pylibcugraph/meta.yaml b/conda/recipes/pylibcugraph/meta.yaml
index 314d8c7ea8b..67df77f5ce6 100644
--- a/conda/recipes/pylibcugraph/meta.yaml
+++ b/conda/recipes/pylibcugraph/meta.yaml
@@ -66,7 +66,6 @@ requirements:
     - pylibraft ={{ minor_version }}
     - python
     - scikit-build-core >=0.7.0
-    - setuptools
   run:
     - {{ pin_compatible('cuda-version', max_pin='x', min_pin='x') }}
     {% if cuda_major == "11" %}
diff --git a/dependencies.yaml b/dependencies.yaml
index e3ff5a4c92c..02823ce5d3d 100644
--- a/dependencies.yaml
+++ b/dependencies.yaml
@@ -71,7 +71,6 @@ files:
       table: build-system
     includes:
       - common_build
-      - python_build_wheel
       - depends_on_rmm
       - depends_on_pylibraft
       - depends_on_pylibcugraph
@@ -105,7 +104,6 @@ files:
       table: build-system
     includes:
       - common_build
-      - python_build_wheel
       - depends_on_rmm
       - depends_on_pylibraft
       - python_build_cythonize
diff --git a/python/cugraph/pyproject.toml b/python/cugraph/pyproject.toml
index 9d222705541..4c42e289e58 100644
--- a/python/cugraph/pyproject.toml
+++ b/python/cugraph/pyproject.toml
@@ -10,8 +10,6 @@ requires = [
     "pylibraft==24.8.*",
     "rmm==24.8.*",
     "scikit-build-core[pyproject]>=0.7.0",
-    "setuptools>=61.0.0",
-    "wheel",
 ] # This list was generated by `rapids-dependency-file-generator`. To make changes, edit ../../dependencies.yaml and run `rapids-dependency-file-generator`.
 build-backend = "scikit_build_core.build"
 
diff --git a/python/pylibcugraph/pyproject.toml b/python/pylibcugraph/pyproject.toml
index 9377d46dee0..fdb82244e37 100644
--- a/python/pylibcugraph/pyproject.toml
+++ b/python/pylibcugraph/pyproject.toml
@@ -9,8 +9,6 @@ requires = [
     "pylibraft==24.8.*",
     "rmm==24.8.*",
     "scikit-build-core[pyproject]>=0.7.0",
-    "setuptools>=61.0.0",
-    "wheel",
 ] # This list was generated by `rapids-dependency-file-generator`. To make changes, edit ../../dependencies.yaml and run `rapids-dependency-file-generator`.
 build-backend = "scikit_build_core.build"