From f9ebad1fb3c3df80523a00e9ab448a816e1f8a13 Mon Sep 17 00:00:00 2001 From: Arian Jamasb Date: Thu, 30 Jun 2022 14:59:20 +0200 Subject: [PATCH] Add support for 3D RNA Graphs (#165) * add RNA atomic edge funcs * add RNA 3D constants * add bpRNA parser * add Ryan's Nussinov algo implementation * add radius of gyration feature * add positional encoding of sequence * update docstrings and add interface subgraphs * docstring * rm unused import * add rich as a base requirement * update version string * black * add additional RNA tests * update rna docs * finalise RNA tutorial with 3D structures * merge * add edge funcs * add RNA graphs * add rna subgraphs * add rna features * update rna constants * resolve circular import * move edge funcs to submodule * make subgraphs editable downstream * set node size multiplier to a saner default * add smiles test file * use rich-click for cli, minor linting * add distance edges * add RNA visualisation * add nussinov test * use rich-click instead of click * add rna test structure * skip nussinov cell to avoid timeout * simplify af2 structure retrieval #168 * add plddt colouring for AF2 * linting * bugfixes for AF2 * add edge distance func * add graph feats to docs * add fully connected and distance window edges * remove erroneous import * add molecule features * add conformer generation and fragment graphs * update top level init with version and loguru logging * update changelog * black, isort * add loguru as dependency * fix edge construction funcs * fix rdkit util tests * fix tests * fix tests * try converting everything to tensor * fix edge distance func * fix conversion * add zinc & chembl utils * add molecule modelling tutorial.ipynb * add smilite dependency * fix notebook test * remove tests for molecule tutorial * update requirements * isort * add sequence homology splitting * update docs * rollback nx version * fix blast * fix blast * add antibody tutorial * update notebook for docs * fix dataset readme tables * add notebooks * update notebooks and docs * remove antibody_dev example * add line graph * update rna tests * update CLI * update ML utils * add dynamics features * add degree oh * fix naming * add naming changes to RNA * update molecule utils * update chain graph tutorial * update intersphinx mappings * isort * black * fix test * skip inconsistent mol test * skip zinc tests * add skip to ppi graph test if HGNC unavailable * remove debug cell * pin nx version * remove nx version pin * pin mpl chord dependency * proper HETATM handling * add pyg visualisation * resolve dataframe handling * update to tutorial for df handling * restore plddt vis * pin scipy version for plots * unpin scipy dependency * skip API calls in tutorials * update changelog * update version to 1.5.0rc1 --- .github/workflows/build.yaml | 2 + .requirements/base.in | 5 +- .requirements/extras.in | 6 +- CHANGELOG.md | 38 +- Dockerfile | 4 + datasets/README.md | 2 + docs/source/conf.py | 6 +- docs/source/dataset_readme.rst | 1 + docs/source/datasets.rst | 1 + docs/source/index.rst | 1 + docs/source/ml_examples.rst | 22 + docs/source/modules/graphein.ml.rst | 15 + docs/source/modules/graphein.molecule.rst | 17 + docs/source/modules/graphein.protein.rst | 5 + docs/source/modules/graphein.rna.rst | 37 +- docs/source/molecule_notebooks.rst | 3 +- .../molecule_model_tutorial_tox.nblink | 3 + .../molecules_from_zinc_and_chembl.nblink | 3 + .../notebooks/splitting_a_dataset.nblink | 3 + .../notebooks/tdc_developability.nblink | 3 + graphein/__init__.py | 20 +- graphein/cli.py | 9 +- graphein/ml/__init__.py | 2 + graphein/ml/clustering.py | 627 + graphein/ml/conversion.py | 29 +- .../ml/datasets/torch_geometric_dataset.py | 22 +- graphein/ml/utils.py | 29 + graphein/ml/visualisation.py | 123 + graphein/molecule/__init__.py | 2 + graphein/molecule/chembl.py | 68 + graphein/molecule/features/graph/molecule.py | 79 +- graphein/molecule/features/nodes/atom_type.py | 7 + graphein/molecule/graphs.py | 60 +- graphein/molecule/utils.py | 469 + graphein/molecule/zinc.py | 100 + graphein/protein/config.py | 4 +- graphein/protein/edges/distance.py | 134 +- graphein/protein/features/graph/__init__.py | 2 + graphein/protein/features/graph/dynamics.py | 51 + graphein/protein/features/graph/structure.py | 61 + graphein/protein/features/nodes/dssp.py | 113 +- .../protein/features/sequence/sequence.py | 79 +- graphein/protein/graphs.py | 436 +- graphein/protein/meshes.py | 6 +- graphein/protein/resi_atoms.py | 393 +- graphein/protein/subgraphs.py | 247 +- graphein/protein/utils.py | 58 +- graphein/protein/visualisation.py | 98 +- graphein/rna/__init__.py | 6 + graphein/rna/config.py | 89 + graphein/rna/constants.py | 210 + graphein/rna/edges/__init__.py | 3 + graphein/rna/edges/atomic.py | 121 + .../rna/{edges.py => edges/base_pairing.py} | 8 + graphein/rna/edges/distance.py | 1 + graphein/rna/features/__init__.py | 0 graphein/rna/features/atom.py | 37 + graphein/rna/graphs.py | 246 +- graphein/rna/nussinov.py | 185 + graphein/rna/subgraphs.py | 478 + graphein/rna/utils.py | 65 + graphein/rna/visualisation.py | 3 + .../alphafold_protein_graph_tutorial.ipynb | 58054 +- notebooks/higher_order_graphs.ipynb | 13413 +- notebooks/molecule_model_tutorial_tox.ipynb | 491 + notebooks/molecule_tutorial.ipynb | 9114 +- notebooks/molecule_utils.ipynb | 16458 + .../molecules_from_zinc_and_chembl.ipynb | 2475 + notebooks/residue_graphs.ipynb | 9413 +- notebooks/rna_graph_tutorial.ipynb | 610547 ++++++++++++++- notebooks/splitting_a_dataset.ipynb | 286 + notebooks/tdc_developability.ipynb | 12508 + setup.py | 11 +- tests/molecule/test_data/short_test.smi | 1 + tests/molecule/test_rdkit_utils.py | 75 + tests/molecule/test_zinc.py | 47 + tests/ppi/test_graphs.py | 14 + tests/protein/nodes/features/test_geometry.py | 6 +- tests/protein/test_graphs.py | 2 +- tests/protein/test_subgraphs.py | 6 - tests/protein/test_utils.py | 26 +- tests/rna/test_data/2jyf.pdb | 27811 + tests/rna/test_graphs.py | 64 +- tests/rna/test_nussinov.py | 10 + tests/rna/test_subgraphs.py | 301 + tests/utils/test_protein_graph_config.yml | 32 +- tests/utils/test_yml_parser.py | 2 +- 87 files changed, 745405 insertions(+), 20719 deletions(-) create mode 100644 docs/source/dataset_readme.rst create mode 100644 docs/source/ml_examples.rst create mode 100644 docs/source/notebooks/molecule_model_tutorial_tox.nblink create mode 100644 docs/source/notebooks/molecules_from_zinc_and_chembl.nblink create mode 100644 docs/source/notebooks/splitting_a_dataset.nblink create mode 100644 docs/source/notebooks/tdc_developability.nblink create mode 100644 graphein/ml/clustering.py create mode 100644 graphein/ml/utils.py create mode 100644 graphein/ml/visualisation.py create mode 100644 graphein/molecule/chembl.py create mode 100644 graphein/molecule/utils.py create mode 100644 graphein/molecule/zinc.py create mode 100644 graphein/protein/features/graph/dynamics.py create mode 100644 graphein/protein/features/graph/structure.py create mode 100644 graphein/rna/config.py create mode 100644 graphein/rna/edges/__init__.py create mode 100644 graphein/rna/edges/atomic.py rename graphein/rna/{edges.py => edges/base_pairing.py} (97%) create mode 100644 graphein/rna/edges/distance.py create mode 100644 graphein/rna/features/__init__.py create mode 100644 graphein/rna/features/atom.py create mode 100644 graphein/rna/nussinov.py create mode 100644 graphein/rna/subgraphs.py create mode 100644 graphein/rna/utils.py create mode 100644 notebooks/molecule_model_tutorial_tox.ipynb create mode 100644 notebooks/molecule_utils.ipynb create mode 100644 notebooks/molecules_from_zinc_and_chembl.ipynb create mode 100644 notebooks/splitting_a_dataset.ipynb create mode 100644 notebooks/tdc_developability.ipynb create mode 100644 tests/molecule/test_data/short_test.smi create mode 100644 tests/molecule/test_rdkit_utils.py create mode 100644 tests/molecule/test_zinc.py create mode 100644 tests/rna/test_data/2jyf.pdb create mode 100644 tests/rna/test_nussinov.py create mode 100644 tests/rna/test_subgraphs.py diff --git a/.github/workflows/build.yaml b/.github/workflows/build.yaml index 28c149dc..1fb98abf 100644 --- a/.github/workflows/build.yaml +++ b/.github/workflows/build.yaml @@ -58,6 +58,8 @@ jobs: run: conda install -c salilab dssp - name: Install PyTorch run: pip install torch==${{matrix.torch}}+cpu torchvision==${{matrix.torchvision}}+cpu -f https://download.pytorch.org/whl/torch_stable.html + - name: Install BLAST + run: sudo apt install ncbi-blast+ - name: Install Graphein run: pip install -e . - name: Install Extras diff --git a/.requirements/base.in b/.requirements/base.in index 8365aede..37cef6c8 100644 --- a/.requirements/base.in +++ b/.requirements/base.in @@ -1,8 +1,8 @@ -biopandas +biopandas>=0.4.1 biopython bioservices -click deepdiff +loguru matplotlib>=3.4.3 multipledispatch networkx @@ -11,6 +11,7 @@ pandas plotly pydantic rich +rich-click seaborn pyyaml>=5.1,<6.* scikit-learn diff --git a/.requirements/extras.in b/.requirements/extras.in index ddc4168e..47b2e078 100644 --- a/.requirements/extras.in +++ b/.requirements/extras.in @@ -1,5 +1,7 @@ biovec propy3 pyaaisc -mpl_chord_diagram -rdkit-pypi \ No newline at end of file +mpl_chord_diagram==0.3.2 +rdkit-pypi +selfies +smilite \ No newline at end of file diff --git a/CHANGELOG.md b/CHANGELOG.md index 80b24e96..b6782068 100644 --- a/CHANGELOG.md +++ b/CHANGELOG.md @@ -1,14 +1,48 @@ ### 1.5.0 - UNRELEASED -* [Patch] - [#178](https://github.com/a-r-j/graphein/pull/178) Fixes [#171](https://github.com/a-r-j/graphein/pull/171) and optimizes `graphein.protein.features.nodes.dssp`. Contribution by @avivko. +#### Protein + +* [Feature] - #165 adds support for direct AF2 graph construction. +* [Feature] - #165 adds support for selecting model indices from PDB files. +* [Feature] - #165 adds support for extracting interface subgraphs from complexes. +* [Feature] - #165 adds support for computing the radius of gyration of a structure. +* [Feature] - #165 adds support for adding distances to protein edges. +* [Feature] - #165 adds support for fully connected edges in protein graphs. +* [Feature] - #165 adds support for distance window-based edges for protein graphs. +* [Feature] - #165 adds support for transformer-like positional encoding of protein sequences. +* [Feature] - #165 adds support for plddt-like colouring of AF2 graphs +* [Feature] - #165 adds support for plotting PyG Data object (e.g. for logging to WandB). * [Feature] - [#170](https://github.com/a-r-j/graphein/pull/170) Adds support for viewing edges in `graphein.protein.visualisation.asteroid_plot`. Contribution by @avivko. -* [Feature] - #163 Adds support for conformer generation for SMILE inputs to molecule graph construction. +* [Patch] - [#178](https://github.com/a-r-j/graphein/pull/178) Fixes [#171](https://github.com/a-r-j/graphein/pull/171) and optimizes `graphein.protein.features.nodes.dssp`. Contribution by @avivko. +* [Patch] - [#174](https://github.com/a-r-j/graphein/pull/174) prevents insertions always being removed. Resolves [#173](https://github.com/a-r-j/graphein/issues/173). Contribution by @OliverT1. +* [Patch] - #165 Refactors HETATM selections. + +#### Molecules + +* [Feature] - #165 adds additional graph-level molecule features. +* [Feature] - #165 adds support for generating conformers (and 3D graphs) from SMILES inputs * [Feature] - #163 Adds support for molecule graph generation from an RDKit.Chem.Mol input. * [Feature] - #163 Adds support for multiprocess molecule graph construction. + +#### RNA + +* [Feature] - #165 adds support for 3D RNA graph construction. +* [Feature] - #165 adds support for generating RNA SS from sequence using the Nussinov Algorithm. + +#### Changes + * [Patch] - #163 uses tqdm.contrib.process_map insteap of multiprocessing.Pool.map to provide progress bars in multiprocessing. +* [Fix] - #165 makes returned subgraphs editable objects rather than views +* [Fix] - #165 fixes global logging set to "debug". +* [Fix] - #165 uses rich progress for protein graph construction. +* [Fix] - #165 sets saner default for node size in 3d plotly plots +* [Dependency] - #165 Changes CLI to use rich-click instead of click for prettier formatting. +* [Package] - #165 Adds support for logging with loguru and rich +* [Package] - Pin BioPandas version to 0.4.1 to support additional parsing features. #### Breaking Changes +* #165 adds RNA SS edges into graphein.protein.edges.base_pairing * #163 changes separate filetype input paths to `graphein.molecule.graphs.construct_graph`. Interface is simplified to simply `path="some/path.extension"` instead of separate inputs like `mol2_path=...` and `sdf_path=...`. ### 1.4.0 - UNRELEASED diff --git a/Dockerfile b/Dockerfile index 87aaeb48..c86d49b1 100644 --- a/Dockerfile +++ b/Dockerfile @@ -8,6 +8,10 @@ RUN apt-get update \ RUN apt-get update && apt-get install -y iputils-ping && apt-get clean \ && rm -rf /var/lib/apt/lists/* +# Install BLAST +RUN apt-get update && apt-get install -y ncbi-blast+ && apt-get clean \ + && rm -rf /var/lib/apt/lists/* + ENV CONDA_ALWAYS_YES=true diff --git a/datasets/README.md b/datasets/README.md index 177d5cdd..186aea9d 100644 --- a/datasets/README.md +++ b/datasets/README.md @@ -40,6 +40,7 @@ These datasets are unions of structural protein-ligand / protein-metal / protein ### [PROTEINS_NUCLEOTIDES](https://github.com/a-r-j/graphein/tree/master/datasets/proteins_nucleotides) [![Open In Colab](https://colab.research.google.com/assets/colab-badge.svg)](https://colab.research.google.com/github/a-r-j/graphein/blob/master/datasets/proteins_nucleotides/parse_dataset.ipynb) + |PDB Ligand |Ligand Name| # Proteins | # Residues | Dataset | |---|---|---|---|---| |[ATP](https://www.rcsb.org/ligand/ATP)| Adenosine Triphosphate | 313 | 127493 | [ATP313](https://github.com/a-r-j/graphein/blob/master/datasets/proteins_nucleotides/ATP.csv) | @@ -54,6 +55,7 @@ These datasets are unions of structural protein-ligand / protein-metal / protein ### [PROTEINS_METAL](https://github.com/a-r-j/graphein/tree/master/datasets/proteins_metal) [![Open In Colab](https://colab.research.google.com/assets/colab-badge.svg)](https://colab.research.google.com/github/a-r-j/graphein/blob/master/datasets/proteins_metal/parse_dataset.ipynb) + |PDB Ligand |Ligand Name| # Proteins | # Residues | Dataset | |---|---|---|---|---| |[Fe](https://www.rcsb.org/ligand/FE)| Iron | 215 | 69779 | [Fe215](https://github.com/a-r-j/graphein/blob/master/datasets/proteins_metal/FE.csv) | diff --git a/docs/source/conf.py b/docs/source/conf.py index 358e781e..e668aa22 100644 --- a/docs/source/conf.py +++ b/docs/source/conf.py @@ -29,7 +29,7 @@ author = "Arian Jamasb" # The full version, including alpha/beta/rc tags -release = "1.4.0" +release = "1.5.0rc1" # -- General configuration --------------------------------------------------- @@ -71,8 +71,12 @@ "xarray": ("https://xarray.pydata.org/en/stable/", None), "pandas": ("https://pandas.pydata.org/docs/", None), "scikit-learn": ("https://scikit-learn.org/stable/", None), + "sklearn": ("https://scikit-learn.org/stable/", None), "scipy": ("https://docs.scipy.org/doc/scipy/reference/", None), "Sphinx": ("https://www.sphinx-doc.org/en/stable/", None), + "networkx": ("https://networkx.github.io/documentation/stable/", None), + "nx": ("https://networkx.github.io/documentation/stable/", None), + "torch": ("https://pytorch.org/docs/master/", None), } mathjax_path = "https://cdn.jsdelivr.net/npm/mathjax@2/MathJax.js?config=TeX-AMS-MML_HTMLorMML" diff --git a/docs/source/dataset_readme.rst b/docs/source/dataset_readme.rst new file mode 100644 index 00000000..30f078f4 --- /dev/null +++ b/docs/source/dataset_readme.rst @@ -0,0 +1 @@ +.. mdinclude:: ../../datasets/README.md \ No newline at end of file diff --git a/docs/source/datasets.rst b/docs/source/datasets.rst index 1a1af77a..6f8bb89e 100644 --- a/docs/source/datasets.rst +++ b/docs/source/datasets.rst @@ -2,6 +2,7 @@ Datasets ============== +.. include:: dataset_readme.rst Summaries diff --git a/docs/source/index.rst b/docs/source/index.rst index e3b28398..7e7c8355 100644 --- a/docs/source/index.rst +++ b/docs/source/index.rst @@ -46,6 +46,7 @@ The repository can be found at `a-r-j/graphein # License: BSD 3 clause # Code Repository: https://github.com/a-r-j/graphein -from .protein import * -from .rna import * -from .testing import * +from loguru import logger +from rich.logging import RichHandler -# from ._version import get_versions +from graphein.utils.utils import * +# from .protein import * +# from .rna import * +from .testing import * __author__ = "Arian Jamasb " +__version__ = "1.5.0rc1" -__version__ = "1.4.0" # get_versions()["version"] -# del get_versions +logger.configure( + handlers=[ + {"sink": RichHandler(rich_tracebacks=True), "format": "{message}"} + ] +) diff --git a/graphein/cli.py b/graphein/cli.py index 8ade7a6a..7c7f1fe8 100644 --- a/graphein/cli.py +++ b/graphein/cli.py @@ -1,8 +1,8 @@ """Command line interface for graphein.""" import pathlib -import click import networkx as nx +import rich_click as click from graphein import __version__ from graphein.protein.graphs import construct_graph @@ -37,14 +37,11 @@ ) def main(config_path, pdb_path, output_path): """Build the graphs and save them in output dir.""" - config = None - if config_path: - config = parse_config(path=config_path) - + config = parse_config(path=config_path) if config_path else None if pdb_path.is_file(): pdb_paths = [pdb_path] elif pdb_path.is_dir(): - pdb_paths = [pdb for pdb in pdb_path.glob("*.pdb")] + pdb_paths = list(pdb_path.glob("*.pdb")) else: raise NotImplementedError( "Given PDB path needs to point to either a pdb file or a directory with pdb files." diff --git a/graphein/ml/__init__.py b/graphein/ml/__init__.py index 2474af4e..4200c8b7 100644 --- a/graphein/ml/__init__.py +++ b/graphein/ml/__init__.py @@ -1,4 +1,6 @@ +from .clustering import * from .conversion import GraphFormatConvertor +from .utils import add_labels_to_graph try: from .datasets import ( diff --git a/graphein/ml/clustering.py b/graphein/ml/clustering.py new file mode 100644 index 00000000..667c51e0 --- /dev/null +++ b/graphein/ml/clustering.py @@ -0,0 +1,627 @@ +""" +Utilities for splitting a protein dataset based on sequence homology. + +NB. These functions require Blast+ for proper execution. On Linux, this can be installed with: + +sudo apt install ncbi-blast+ + +Otherwise, please see: https://blast.ncbi.nlm.nih.gov/Blast.cgi?CMD=Web&PAGE_TYPE=BlastDocs&DOC_TYPE=Download +""" + +import contextlib +import os +import random +import sys +from typing import Dict, List, Optional + +import networkx as nx +import numpy as np +import pandas as pd +from Bio import SeqIO + +from graphein.protein.utils import is_tool + + +def build_fasta_file_from_mapping( + pdb_sequence_mapping: Dict[str, str], + fasta_out: str, +): + """ + Builds a fasta database from a mapping of PDBs (or other identifier) to sequences. + + :param pdb_sequence_mapping: dictionary with the sequence of each pdb file + :type pdb_sequence_mapping: Dict[str, str] + :param fasta_out: file name of the fasta database + :type fasta_out: str + """ + with open(fasta_out, mode="w") as f_out: + for k, v in pdb_sequence_mapping.items(): + seq_id = k + print(f">{seq_id}\n{v}", file=f_out) + + +def build_fasta_file_from_graphs( + graphs: List[nx.Graph], fasta_out: str, chains: Optional[List[str]] = None +): + if chains is None: + chains = ["A"] * len(graphs) + mapping = { + g.name + "_" + chain: g.graph[f"sequence_{chain}"] + for g, chain in zip(graphs, chains) + } + + build_fasta_file_from_mapping(mapping, fasta_out) + + +def get_seq_records( + filename, + alphabet=None, # alphabet=generic_protein, + check_sequences=False, + file_format="fasta", + return_as_dictionary=False, +): + """ + Get the sequence records from a file. + + :param filename: File with sequences [fasta in our case]. + :type filename: str + :param alphabet: alphabet to be used. + :param check_sequences: Sanity check on the sequences. + :type check_sequences: bool + :param file_format: We use fasta format (don't change this). + :type file_format: str + :param return_as_dictionary: if ``True`` uses ``records.to_dict()`` to convert the record into a dictionary and return it. + :type return_as_dictionary: bool + :return: a list of the ``SeqRecord`` of the sequences. + - ``.seq``: access the records (sequence, i.e. ``Seq``, for actual string use ``str(records[].seq))`` + - ``.id``: access the ids in the file + - ``.name``: access names (sometimes equal to ``id``, depends on format) + - ``.description``: is the description (when included) + - ``.dbxref`` which (if present) is a list with the cross-referenced database + Notes: + ------ + For a list of available file_format see http://biopython.org/wiki/SeqIO#File_Formats .aln is generally 'clustal' + """ + if alphabet is None and check_sequences: + sys.stderr.write( + f"WARNING in {get_seq_records.__name__} ask to check_sequences but no " + "Alphabet given. Only checking for terminating *!\n" + ) + check_sequences = False + with open(filename, "rU") as handle: + records = list(SeqIO.parse(handle, file_format, alphabet=alphabet)) + del handle + if check_sequences: + for record in records: + if record.seq[-1] == "*": + record.seq = record.seq[:-1] + if alphabet is not None: + good = False + with contextlib.suppress(ValueError): + good = _verify_alphabet(record.seq) + if not good: + sys.stderr.write( + f"WARNING in {get_seq_records.__name__} sequence {record.seq.id} from file " + f"{filename} is not compatible with declared alphabet {str(alphabet)}\n" + ) + if return_as_dictionary: + return SeqIO.to_dict(records) + return records + + +def create_pairs_for_clustering( + fasta_file: str, + seq_id_low_thresh: float = 25.0, + use_very_loose_condition: bool = False, + out_file: Optional[str] = None, + n_cpu: int = 1, + max_target_seqs: int = 200, + delete_blast_databases_when_done: bool = False, +): + """ + Create sequences pairs for clustering [sequence names MUST be the ids!]. + + :param fasta_file: file with fastas + :type fasta_file: str + :param seq_id_low_thresh: sequence identity of lower threshold + :type seq_id_low_thresh: float + :param use_very_loose_condition: ?? + :type use_very_loose_condition: bool + :param out_file: name of the output file + :type out_file: str + :param n_cpu: number of cpus to be used + :type n_cpu: int + :param max_target_seqs: ?? + :type max_target_seqs: int + :param delete_blast_databases_when_done: delete the db once the process is finished + :type delete_blast_databases_when_done: bool + :return: + """ + if out_file is None: + out_file = "pairs_for_clustering.txt" + rec = get_seq_records(fasta_file) + # blast each sequence on the database to get the identity pairs + pairs = [] + corresponding_identities = [] + for s in rec: + pairs += [(s.id, s.id)] + corresponding_identities += [100.0] + b_res = blast( + s, + fasta_file, + max_target_seqs=max_target_seqs, + n_cpu=n_cpu, + delete_blast_file=True, + ) + if ( + b_res is None + ): # blast sometimes does not hit the very same sequence (with blst+ it should) + continue + if use_very_loose_condition: + _, d_res = process_blast_results( + b_res, + len(s.seq), + return_dictionary_of_numpy_matrices=True, + filter_best_match_for_same_subject=False, + add_identity_on_shortest=False, + ) + for k in d_res: + if k == s.id: + continue # we added this manually at the beginning + max_id = max( + d_res[k][:, 0] + ) # maximum identity between different possible alignments + if not 0 <= max_id <= 100: + print(f"Max_id problem: {max_id}, {k}, {s.id}") + if ( + max_id > seq_id_low_thresh + and frozenset([k, s.id]) not in pairs + ): + pairs += [frozenset([s.id, k])] + corresponding_identities += [max_id] + else: + b_res = process_blast_results( + b_res, + len(s.seq), + return_dictionary_of_numpy_matrices=False, + filter_best_match_for_same_subject=True, + add_identity_on_shortest=True, + ) + for p in b_res: + if p[0] == s.id: + continue # we added this manually at the beginning + if p[-1] > seq_id_low_thresh: + pairs += [frozenset([s.id, p[0]])] + corresponding_identities += [p[-1]] + + if out_file is not None: + out = open(out_file, "w") + done = {} + for j, p in enumerate(pairs): + if out_file is not None: + if p in done: + continue + ff = list(p) + out.write( + "%s\t%s\t%lf\n" % (ff[0], ff[1], corresponding_identities[j]) + ) + done[p] = corresponding_identities[j] + if out_file is not None: + out.close() + if delete_blast_databases_when_done: + os.system(f"rm -f {fasta_file}.phr {fasta_file}.pin {fasta_file}.psq") + return done + + +def clustering_from_pairs(pairs, out_file=None): + """ + Clustering of a set of elements given a list of 'homologous' with possibly false negatives + :param pairs: pair of sequences + :param out_file: output file + :return: the clusters + """ + clusters = [] + j = 0 + key_to_cluster = {} + for p in pairs: + p = list(p) + if p[0] in key_to_cluster and p[1] not in key_to_cluster: + if p[1] not in clusters[key_to_cluster[p[0]]]: + clusters[key_to_cluster[p[0]]].append(p[1]) + key_to_cluster[p[1]] = key_to_cluster[p[0]] + elif p[1] in key_to_cluster and p[0] not in key_to_cluster: + if p[0] not in clusters[key_to_cluster[p[1]]]: + clusters[key_to_cluster[p[1]]].append(p[0]) + key_to_cluster[p[0]] = key_to_cluster[p[1]] + elif p[1] in key_to_cluster: + if key_to_cluster[p[1]] != key_to_cluster[p[0]]: + # we leave p1 empty and we put all in p0, loop backward to remove stuff... + del_id = key_to_cluster[p[1]] + c = len(clusters[del_id]) - 1 + while c >= 0: + el = clusters[del_id][c] + if el in key_to_cluster: + del key_to_cluster[el] + if el not in clusters[key_to_cluster[p[0]]]: + clusters[key_to_cluster[p[0]]].append(el) + key_to_cluster[el] = key_to_cluster[p[0]] + del clusters[del_id][c] + c -= 1 + else: # add a new cluster + key_to_cluster[p[0]] = j + if p[0] == p[1]: + clusters.append([p[0]]) + else: + clusters.append([p[0], p[1]]) + key_to_cluster[p[1]] = j + j += 1 + del key_to_cluster + c = len(clusters) - 1 + while c >= 0: + if not clusters[c]: + del clusters[c] + c -= 1 + if out_file is not None: + with open(out_file, "w") as out: + for c in clusters: + out.write("%s\n" % (" ".join(c))) + return clusters + + +def blast( + sequence, + database, + ungapped=False, + add_sseq=False, + add_qseq=False, + tmp_folder="/tmp/", + blast_path="", + sequence_name="", + blast_filename="blast" + str(os.getpid()) + ".txt", + max_target_seqs=100, + n_cpu=1, + delete_blast_file=True, +): + """ + Given a sequence and a database file (e.g. a .fasta file with some sequences) blasts the sequence on the database + + :param sequence: sequence of reference + :param database: database against which to blast the sequence + :param return_csv_data_class: Returns a dict with as keys subject_id and as value the list (without subject_id). + This also contain a header under .hd + :param ungapped: + :param add_sseq: append to the returned list the keywords sseq (aligned part of subject sequence) + :param add_qseq: append to the returned list the keywords qseq (aligned part of query sequence) + :param tmp_folder: temporary folder + :param blast_path: path to blast installation folder + :param sequence_name: name of the sequence + :param blast_filename: filename for the blast file + :param max_target_seqs: maximum number of target sequences + :param n_cpu: number of cpus + :param delete_blast_file: if True deletes the blast file at the end + :return: a list of lists. + - each list is a possible match (best is at index 0) + - if there is no matching it returns None + - The inner part is: + [subject_id (name of the match), identity (percentage), alignment_length, + mismatches (number within alignment length), gaps (number within alignment length), + q_start (start index in the query sequence), q_end (end index), + s_start (start index in the matching sequence), s_end (end index), evalue, + nident (number of identical amino acids in aligned region), slen (sublect length)] + Notes + ----- + Check that NCBI blast is correctly installed in the folder blast_path + """ + + if tmp_folder is None: + tmp_folder = "" + elif tmp_folder != "": + if tmp_folder[-1] != "/": + tmp_folder += "/" + if delete_blast_file and tmp_folder not in blast_filename: + blast_filename = tmp_folder + blast_filename + if type(sequence) is not str: # we assume is a Seq object + sequence_name = sequence.id + sequence = str(sequence.seq) + if blast_path != "" and not os.path.isfile( + blast_path + "makeblastdb" + ): # check if the BLAST_PATH is correct + raise IOError( + f"***ERROR*** in run_blast path {blast_path} doesnt lead to blast directory " + "where makeblastdb should be located" + ) + seq_file = open(tmp_folder + "sequence_temp.txt", "w") + seq_file.write(">" + sequence_name + "\n" + sequence + "\n") + seq_file.close() + + # check if the blast database has already been built, if not build it + if not ( + os.path.isfile(database + ".phr") + and os.path.isfile(database + ".pin") + and os.path.isfile(database + ".psq") + ): + try: + os.system(blast_path + "makeblastdb -dbtype prot -in " + database) + except Exception: + print( + "***ERROR*** in run_blast() cannot build blast database maybe you wish to " + "set BLAST_PATH to correct directory" + ) + raise + ungapped = " -comp_based_stats F -ungapped" if ungapped else "" + table_k = "6 sseqid pident length mismatch gapopen qstart qend sstart send evalue nident slen" + if add_sseq: + table_k += " sseq" + if add_qseq: + table_k += " qseq" + + # SHORT SEQUENCES: -task 'blastp-short' -word_size 2 -seg 'no' -evalue 20000 + if len(sequence) <= 15: + os.system( + blast_path + + "blastp -query " + + tmp_folder + + "sequence_temp.txt -db " + + database + + " -matrix PAM30 -task 'blastp-short' -word_size 2 -seg 'no' -evalue 20000 -out " + + blast_filename + + f" -outfmt '{table_k}'" + + ungapped + + " -max_target_seqs " + + str(max_target_seqs) + + " -num_threads " + + str(n_cpu) + ) + else: + os.system( + blast_path + + "blastp -query " + + tmp_folder + + "sequence_temp.txt -db " + + database + + " -out " + + blast_filename + + f" -outfmt '{table_k}'" + + ungapped + + " -max_target_seqs " + + str(max_target_seqs) + + " -num_threads " + + str(n_cpu) + ) + resultf = open(blast_filename, mode="r").read().splitlines() + + results = [] + if len(resultf) == 0: + return None + for line in resultf: + tmp = line.split("\t") + numb_list = [tmp[0]] + list(map(lambda x: float(x), tmp[1:])) + results.append(numb_list) + if delete_blast_file: + os.system("rm -f " + blast_filename) + os.system("rm -f " + tmp_folder + "sequence_temp.txt") + del resultf + return results + + +def process_blast_results( + blast_results_list, + len_of_query, + return_dictionary_of_numpy_matrices=False, + filter_best_match_for_same_subject=True, + add_identity_on_shortest=True, +): + """ + If filter_best_match_for_same_subject is True than only the first among the possible alignments of the query + with that subject sequence is kept. Blast results are sorted according to subject sequences and then to + evalue + :param blast_results_list: + :param len_of_query: + :param return_dictionary_of_numpy_matrices: + :param filter_best_match_for_same_subject: + :param add_identity_on_shortest: + :return: + """ + if not isinstance(len_of_query, int): + print( + f"WARNING in {process_blast_results.__name__} type(len_of_query) is not Int, " + "probably screwing results up!!" + ) + if blast_results_list is None: + return ([], {}) if return_dictionary_of_numpy_matrices else [] + if ( + not filter_best_match_for_same_subject + and not add_identity_on_shortest + and not return_dictionary_of_numpy_matrices + ): + return blast_results_list + last_subj = "" + new_results = [] + if return_dictionary_of_numpy_matrices: + subjects_dict = {} + for res in blast_results_list: + if return_dictionary_of_numpy_matrices: + if res[0] not in subjects_dict: + subjects_dict[res[0]] = np.array( + res[1:], dtype=np.float64, ndmin=2 + ) # this removes the ID + else: + subjects_dict[res[0]] = np.vstack( + ( + subjects_dict[res[0]], + np.array(res[1:], dtype=np.float64), + ) + ) + if filter_best_match_for_same_subject and list(res)[0] == last_subj: + continue + if add_identity_on_shortest: + den = 1.0 * min([res[-1], len_of_query]) + new_results.append(res + [100.0 * res[-2] / den]) + else: + new_results.append(res) + last_subj = res[0] + if return_dictionary_of_numpy_matrices: + return new_results, subjects_dict + return new_results + + +def generate_random_sets( + clusters, + number_of_sets=10, + fraction_in_test=0.1, + train_set_key="LR", + test_set_key="TS", + early_break=True, +): + """ + Generate random sets from clusters. + + :param clusters: input clusters + :param number_of_sets: total number of sets to generate + :param fraction_in_test: fraction of sequences to be put in test + :param train_set_key: Prefix to add to train set + :param test_set_key: Prefix to add to test set + :param early_break: if True, break after a suitable combination of training-test set is generated to feed the model + :return: + """ + if type(clusters) is str and os.path.isfile(clusters): + clusters = open(clusters, mode="r").read().splitlines() + clusters = [cl.split() for cl in clusters] + num_ids = 0 + c_sizes = [] + for c in clusters: + c_sizes += [len(c)] + num_ids += len(c) + print(f"{num_ids} ids in {len(clusters)} clusters") + random.seed(a=42) # for reproducibility + n = 0 + in_other_tests = [] + while n < number_of_sets: + train_set_name = train_set_key + f"_{n:02}" + test_set_name = test_set_key + f"_{n:02}" + with open(train_set_name, mode="w") as train: + with open(test_set_name, mode="w") as test: + ids_in_test = [] + labs_in_test = [] + test_rel_size = 0.0 + seq_in_test = 0 + while test_rel_size < fraction_in_test: + cl_id = int(random.random() * len(clusters)) + while cl_id in in_other_tests: + cl_id = int(random.random() * len(clusters)) + in_other_tests += [cl_id] + if len(in_other_tests) == len(clusters): + print( + f"\nWARNING in {generate_random_sets.__name__} we have already generated test files" + " with all clusters.\nNew test files will share clusters with existing ones...\n" + f"Starting from {n} included...\n" + ) + in_other_tests = [] + ids_in_test += [cl_id] + for idt in clusters[cl_id]: + print(f"{str(idt)}", file=test) + labs_in_test.append(idt) + test_rel_size += 1.0 * c_sizes[cl_id] / float(num_ids) + seq_in_test += c_sizes[cl_id] + for j in range(len(clusters)): + if j not in ids_in_test: + for idt in clusters[j]: + print(f"{str(idt)}", file=train) + print( + f"Generated set {train_set_name} and {test_set_name} - {seq_in_test} sequences" + f" for {len(ids_in_test)} clusters in test, among ({num_ids}, {len(clusters)}) in total." + f" Test relative size is {test_rel_size}" + ) + if abs(test_rel_size - fraction_in_test) < 0.05 and early_break: + return labs_in_test + n += 1 + + +def train_and_test_from_fasta( + fasta_file: str, + number_of_sets: int = 10, + fraction_in_test: float = 0.1, + cluster_file_name: str = "s2d_clusters.txt", + seq_id_low_thresh: float = 25.0, + use_very_loose_condition: bool = False, + n_cpu: int = 2, + max_target_seqs: int = 200, + delete_db_when_done: bool = True, + train_set_key: str = "LR", + test_set_key: str = "TS", + early_break: bool = True, +): + """ + Use a fasta database to generate test and training sets based on user defined parameters. + + :param fasta_file: Fasta file name. + :type fasta_file: str + :param number_of_sets: Number of sets to generate. + :type number_of_sets: int + :param fraction_in_test: Fraction of proteins to be put in test set. + :type fraction_in_test: float + :param cluster_file_name: Name of the cluster file. + :type cluster_file_name: str + :param seq_id_low_thresh: Sequence identity lower threshold. + :type seq_id_low_thresh: float + :param use_very_loose_condition: ignore + :type use_very_loose_condition: bool + :param n_cpu: Number of cpus. + :type n_cpu: int + :param max_target_seqs: Maximum number of target sequences. + :type max_target_seqs: int + :param delete_db_when_done: if ``True`` delete the blast database when done. + :type delete_db_when_done: bool + :param train_set_key: Prefix to append to training files. + :type train_set_key: str + :param test_set_key: Prefix to append to test files. + :type test_set_key: str + :param early_break: if ``True``, break after a suitable combination of training-test set is generated to feed the model. + :type early_break: bool + :return: save clusters in files (or return the 1st suitable one). + """ + if not 0 < fraction_in_test < 1: + print( + f"ERROR in {train_and_test_from_fasta.__name__}, fraction_in_test has to be in [0,1] now {fraction_in_test}" + ) + + print( + "Clustering proteins by sequence identity\n" + "----------------------------------------\n" + "Parameters:\n" + f" - Number of sets to split: {number_of_sets}\n" + f" - Sequence identity low threshold: {seq_id_low_thresh}%\n" + f" - Fraction of sequences in test set: {fraction_in_test}" + ) + print("\n\n*** Creating sequences pairs for clustering") + pairs = create_pairs_for_clustering( + fasta_file, + seq_id_low_thresh=seq_id_low_thresh, + use_very_loose_condition=use_very_loose_condition, + out_file=None, + n_cpu=n_cpu, + max_target_seqs=max_target_seqs, + delete_blast_databases_when_done=delete_db_when_done, + ) + print("*** Clustering from pairs of sequences") + clusters = clustering_from_pairs(pairs, out_file=cluster_file_name) + print("*** Generating sets") + if early_break: + return generate_random_sets( + clusters, + number_of_sets=number_of_sets, + fraction_in_test=fraction_in_test, + train_set_key=train_set_key, + test_set_key=test_set_key, + early_break=early_break, + ) + + generate_random_sets( + clusters, + number_of_sets=number_of_sets, + fraction_in_test=fraction_in_test, + train_set_key=train_set_key, + test_set_key=test_set_key, + early_break=early_break, + ) + return diff --git a/graphein/ml/conversion.py b/graphein/ml/conversion.py index c6c39372..010f418e 100644 --- a/graphein/ml/conversion.py +++ b/graphein/ml/conversion.py @@ -17,6 +17,7 @@ from graphein.utils.utils import import_message try: + import torch_geometric from torch_geometric.data import Data except ImportError: import_message( @@ -351,11 +352,21 @@ def convert_nx_to_jraph(self, G: nx.Graph) -> jraph.GraphsTuple: for i, (_, feat_dict) in enumerate(G.nodes(data=True)): for key, value in feat_dict.items(): if str(key) in self.columns: - node_features[str(key)] = ( + # node_features[str(key)] = ( + # [value] + # if i == 0 + # else node_features[str(key)] + [value] + # ) + feat = ( [value] if i == 0 else node_features[str(key)] + [value] ) + try: + feat = torch.tensor(feat) + node_features[str(key)] = feat + except TypeError: + node_features[str(key)] = feat # Add edge features edge_features = {} @@ -421,19 +432,3 @@ def convert_nx_to_pyg_data(G: nx.Graph) -> Data: data.num_nodes = G.number_of_nodes() return data - - -if __name__ == "__main__": - from graphein.protein.config import ProteinGraphConfig - from graphein.protein.graphs import construct_graph - - g = construct_graph(pdb_code="3eiy", config=ProteinGraphConfig()) - assert type(g) is nx.Graph - - # print(SUPPORTED_FORMATS) - - convertor = GraphFormatConvertor( - src_format="nx", dst_format="pyg", verbose="gnn" - ) - pyg = convertor(g) - assert type(pyg) is torch_geometric.data.Data diff --git a/graphein/ml/datasets/torch_geometric_dataset.py b/graphein/ml/datasets/torch_geometric_dataset.py index 8a62b6ab..666f229e 100644 --- a/graphein/ml/datasets/torch_geometric_dataset.py +++ b/graphein/ml/datasets/torch_geometric_dataset.py @@ -6,6 +6,7 @@ # Code Repository: https://github.com/a-r-j/graphein from __future__ import annotations +import logging as log import os from pathlib import Path from typing import Callable, Dict, List, Optional @@ -206,6 +207,7 @@ def process(self): # Apply transformations to raw PDB files. if self.pdb_transform is not None: + print("Transforming PDB files...") self.transform_pdbs() if self.chain_selection_map: @@ -219,6 +221,7 @@ def process(self): chain_selections = None # Create graph objects + print("Constructing Graphs...") graphs = construct_graphs_mp( pdb_path_it=structure_files, config=self.config, @@ -228,32 +231,45 @@ def process(self): ) # Transform graphs if self.graph_transformation_funcs is not None: + print("Transforming Nx Graphs...") for func in self.graph_transformation_funcs: graphs = {k: func(v) for k, v in graphs.items()} # Convert to PyTorch Geometric Data + print("Converting Graphs...") graphs = {k: self.graph_format_convertor(v) for k, v in graphs.items()} graphs = dict(zip(self.structures, graphs.values())) # Assign labels if self.graph_label_map: + print("Assigning graph Labels...") for k, v in self.graph_label_map.items(): - graphs[k].graph_y = v + try: + graphs[k].graph_y = v + except KeyError: + print(f"{k} not found in graphs. Skipping.") if self.node_label_map: + print("Assigning node Labels...") for k, v in self.node_label_map.items(): - graphs[k].node_y = v - + try: + graphs[k].node_y = v + except KeyError: + print(f"{k} not found in graphs. Skipping.") data_list = list(graphs.values()) del graphs if self.pre_filter is not None: + print("Pre-filtering Data...") data_list = [g for g in data_list if self.pre_filter(g)] if self.pre_transform is not None: + print("Pre-transforming data...") data_list = [self.pre_transform(data) for data in data_list] + print("Saving Data...") data, slices = self.collate(data_list) torch.save((data, slices), self.processed_paths[0]) + print("Done!") class ProteinGraphDataset(Dataset): diff --git a/graphein/ml/utils.py b/graphein/ml/utils.py new file mode 100644 index 00000000..feb1c11e --- /dev/null +++ b/graphein/ml/utils.py @@ -0,0 +1,29 @@ +"""ML utility Functions for working with graphs.""" +# Graphein +# Author: Arian Jamasb +# License: MIT + +# Project Website: https://github.com/a-r-j/graphein +# Code Repository: https://github.com/a-r-j/graphein +from typing import Any, List + +import networkx as nx + + +def add_labels_to_graph( + graphs: List[nx.Graph], labels: List[Any], name: str +) -> List[nx.Graph]: + """Adds labels to a graph. + + :param graphs: A list of graphs to add labels to. + :type graphs: List[nx.Graph] + :param labels: A list of labels to add to the graphs. + :type labels: List[Any] + :param name: The name to add the label under. + :type name: str + :return: A list of graphs with labels added. + :rtype: List[nx.Graph] + """ + for i, g in enumerate(graphs): + g.graph[name] = labels[i] + return graphs diff --git a/graphein/ml/visualisation.py b/graphein/ml/visualisation.py new file mode 100644 index 00000000..711cb50a --- /dev/null +++ b/graphein/ml/visualisation.py @@ -0,0 +1,123 @@ +"""Visualisation utils for ML.""" +from __future__ import annotations + +from typing import Optional, Tuple + +import matplotlib.pyplot as plt +import networkx as nx +import plotly.graph_objects as go + +from graphein.utils.utils import import_message + +from ..protein.visualisation import plotly_protein_structure_graph +from .conversion import GraphFormatConvertor + +try: + from torch_geometric.data import Data +except ImportError: + import_message( + submodule="graphein.ml.conversion", + package="torch_geometric", + pip_install=True, + conda_channel="rusty1s", + ) + +try: + import torch +except ImportError: + import_message( + submodule="graphein.ml.visualisation", + package="torch", + pip_install=True, + conda_channel="pytorch", + ) + + +def plot_pyg_data( + x: Data, + node_colour_tensor: Optional[torch.Tensor] = None, + edge_colour_tensor: Optional[torch.Tensor] = None, + plot_title: Optional[str] = None, + figsize: Tuple[int, int] = (620, 650), + node_alpha: float = 0.7, + node_size_min: float = 20.0, + node_size_multiplier: float = 20.0, + label_node_ids: bool = True, + node_colour_map=plt.cm.plasma, + edge_color_map=plt.cm.plasma, + colour_nodes_by: str = "residue_name", + colour_edges_by: Optional[str] = None, +) -> go.Figure: + """ + Plots protein structure graph from ``torch_geometric.data.Data`` using plotly. + + This function can be used for logging proteins to e.g. wandb. + + :param x: ``torch_geometric.data.Data`` Protein Structure graph to plot. + :type x: torch_geometric.data.Data + :param node_colour_tensor: Tensor of node colours (must match length of nodes in graph). + If ``None``, ``colour_nodes_by`` will be used. Default is ``None``. + :type node_colour_tensor: torch.Tensor, optional + :parm edge_colour_tensor: Tensor of edge colours (must match length of edges in graph). + If ``None``, ``colour_edges_by`` will be used. Default is ``None``. + :type edge_colour_tensor: torch.Tensor, optional + :param plot_title: Title of plot, defaults to ``None``. + :type plot_title: str, optional + :param figsize: Size of figure, defaults to ``(620, 650)``. + :type figsize: Tuple[int, int] + :param node_alpha: Controls node transparency, defaults to ``0.7``. + :type node_alpha: float + :param node_size_min: Specifies node minimum size. Defaults to ``20.0``. + :type node_size_min: float + :param node_size_multiplier: Scales node size by a constant. Node sizes reflect degree. Defaults to ``20.0``. + :type node_size_multiplier: float + :param label_node_ids: bool indicating whether or not to plot ``node_id`` labels. Defaults to ``True``. + :type label_node_ids: bool + :param node_colour_map: colour map to use for nodes. Defaults to ``plt.cm.plasma``. + :type node_colour_map: plt.cm + :param edge_color_map: colour map to use for edges. Defaults to ``plt.cm.plasma``. + :type edge_color_map: plt.cm + :param colour_nodes_by: Specifies how to colour nodes. ``"degree"``, ``"seq_position"`` or a node feature. + :type colour_nodes_by: str + :param colour_edges_by: Specifies how to colour edges. Currently only ``"kind"`` or ``None`` are supported. + :type colour_edges_by: Optional[str] + :returns: Plotly Graph Objects plot + :rtype: go.Figure + """ + convertor = GraphFormatConvertor(src_format="pyg", dst_format="nx") + nx_graph = convertor(x) + node_map = dict(enumerate(x.node_id)) + nx_graph = nx.relabel_nodes(nx_graph, node_map) + + # Add metadata + nx_graph.name = x.name + nx_graph.graph["coords"] = x.coords[0] + nx_graph.graph["dist_mat"] = x.dist_mat + + # Assign coords and seq info to nodes + for i, (_, d) in enumerate(nx_graph.nodes(data=True)): + d["chain_id"] = x.node_id[i].split(":")[0] + d["residue_name"] = x.node_id[i].split(":")[1] + d["seq_position"] = x.node_id[i].split(":")[2] + d["coords"] = x.coords[0][i] + if node_colour_tensor is not None: + d["colour"] = float(node_colour_tensor[i]) + + if edge_colour_tensor is not None: + # TODO add edge types + for i, (_, _, d) in enumerate(nx_graph.edges(data=True)): + d["colour"] = float(edge_colour_tensor[i]) + + return plotly_protein_structure_graph( + nx_graph, + plot_title, + figsize, + node_alpha, + node_size_min, + node_size_multiplier, + label_node_ids, + node_colour_map, + edge_color_map, + colour_nodes_by if node_colour_tensor is None else "colour", + colour_edges_by if edge_colour_tensor is None else "colour", + ) diff --git a/graphein/molecule/__init__.py b/graphein/molecule/__init__.py index 69cf16c4..11323bcf 100644 --- a/graphein/molecule/__init__.py +++ b/graphein/molecule/__init__.py @@ -1,6 +1,8 @@ from .atoms import * +from .chembl import * from .config import * from .edges import * from .features import * from .graphs import * from .visualisation import * +from .zinc import * diff --git a/graphein/molecule/chembl.py b/graphein/molecule/chembl.py new file mode 100644 index 00000000..d16ef11d --- /dev/null +++ b/graphein/molecule/chembl.py @@ -0,0 +1,68 @@ +"""Functions for retrieving molecular data from ChEMBL.""" +from typing import Any, Dict + +import networkx as nx + +# %% +# Graphein +# Author: Arian Jamasb +# License: MIT +# Project Website: https://github.com/a-r-j/graphein +# Code Repository: https://github.com/a-r-j/graphein +from bioservices import ChEMBL + + +def get_smiles_from_chembl(chembl_id: str) -> str: + """Retrieves a SMILE string from a ChEMBL ID. + + :param chembl_id: ChEMBL ID, e.g., ``'CHEMBL1234'`` + :type smiles: str + :returns: A SMILE string, e.g., + ``'COc1cccc(c1)NC(=O)c2cccnc2'`` + :rtype: str + """ + chembl = ChEMBL() + data = chembl.get_molecule(chembl_id) + return data["molecule_structures"]["canonical_smiles"] + + +def get_chembl_id_from_smiles(smiles: str) -> str: + """Retrieves a ChEMBL ID from a SMILE string. + + :param smiles: A valid SMILE string, e.g., + ``'COc1cccc(c1)NC(=O)c2cccnc2'`` + :type smiles: str + :return: ChEMBL ID, e.g., ``'CHEMBL1234'`` + :rtype: str + """ + chembl = ChEMBL() + data = chembl.get_molecule(smiles) + return data["molecule_chembl_id"] + + +def get_chembl_metadata(query: str) -> Dict[str, Any]: + """Retrieves metadata from ChEMBL for a SMILE string or ChEMBL ID. + + :param query: A valid SMILE string or ChEMBL ID, e.g. + ``'CHEMBL1234'`` or ``'COc1cccc(c1)NC(=O)c2cccnc2'`` + :type query: str + :return: A dictionary of metadata. + :rtype: Dict[str, Any] + """ + chembl = ChEMBL() + return chembl.get_molecule(query) + + +def add_chembl_metadata(g: nx.Graph) -> nx.Graph: + """ + Add ChEMBL metadata to the graph. + + :param g: The graph to add metadata to. + :type g: nx.Graph + :return: Graph with ChEMBL metadata added. + :rtype: nx.Graph + """ + # Get the SMILE + smiles = g.graph["smiles"] + g.graph["chembl_metadata"] = get_chembl_metadata(smiles) + return g diff --git a/graphein/molecule/features/graph/molecule.py b/graphein/molecule/features/graph/molecule.py index e5dd9d6a..1e6cfe72 100644 --- a/graphein/molecule/features/graph/molecule.py +++ b/graphein/molecule/features/graph/molecule.py @@ -13,6 +13,16 @@ import numpy as np import pandas as pd +from graphein.molecule.utils import ( + count_fragments, + get_center, + get_max_ring_size, + get_mol_weight, + get_morgan_fp, + get_morgan_fp_np, + get_qed_score, + get_shape_moments, +) from graphein.utils.utils import import_message try: @@ -20,7 +30,7 @@ from rdkit.Chem import Descriptors except ImportError: import_message( - "graphein.molecule.features.graph.molecule", "rdkit", "rdkit", True + "graphe in.molecule.features.graph.molecule", "rdkit", "rdkit", True ) @@ -67,3 +77,70 @@ def mol_descriptors( g.graph.update(desc) return desc + + +def add_center_of_mol( + g: nx.Graph, weights: Optional[np.ndarray] = None +) -> nx.Graph: + """Compute the centroid of the conformation. + + Hydrogens are ignored and no attention is paid to the difference in sizes + of the heavy atoms; however, an optional vector of weights can be passed. + + :param g: Molecular Graph or RDkit Mol to compute the center of. + :type g: nx.Graph + :return: Graph with the centroid of the molecule added as a graph feature. + :rtype: np.ndarray + """ + g.graph["center"] = get_center(g, weights=weights) + return g + + +def add_shape_moments(g: nx.Graph): + """Add principal moments of inertia as defined in https://pubs.acs.org/doi/10.1021/ci025599w + + :param mol: Molecular Graph or RDkit Mol to compute the moments of intertia of. + :type mol: Union[nx.Graph, Chem.Mol] + :return: First 2 moments as a tuple. + :rtype: Tuple[float, float] + """ + g.graph["shape_moments"] = get_shape_moments(g) + return g + + +def add_max_ring_size(g: nx.Graph) -> nx.Graph: + g.graph["max_ring_size"] = get_max_ring_size(g) + return g + + +def add_morgan_fingerprint( + g: nx.Graph, radius: int = 2, n_bits: int = 2048 +) -> nx.Graph: + g.graph["morgan_fingerprint"] = get_morgan_fp( + g, radius=radius, n_bits=n_bits + ) + return g + + +def add_morgan_fingerprint_np( + g: nx.Graph, radius: int = 2, n_bits: int = 2048 +) -> nx.Graph: + g.graph["morgan_fingerprint_np"] = get_morgan_fp_np( + g, radius=radius, n_bits=n_bits + ) + return g + + +def add_fragment_counts(g: nx.Graph) -> nx.Graph: + g.graph["fragment_counts"] = count_fragments(g) + return g + + +def add_mol_weight(g: nx.Graph) -> nx.Graph: + g.graph["mol_weight"] = get_mol_weight(g) + return g + + +def add_qed_score(g: nx.Graph) -> nx.Graph: + g.graph["qed"] = get_qed_score(g) + return g diff --git a/graphein/molecule/features/nodes/atom_type.py b/graphein/molecule/features/nodes/atom_type.py index bb8f3ec2..008f06ea 100644 --- a/graphein/molecule/features/nodes/atom_type.py +++ b/graphein/molecule/features/nodes/atom_type.py @@ -67,6 +67,13 @@ def degree(n: str, d: Dict[str, Any]) -> int: return degree +def degree_one_hot(n: str, d, allowable_set: List[int]): + deg = degree(n, d) + deg = onek_encoding_unk(deg, allowable_set) + d["degree"] = deg + return deg + + def total_degree(n: str, d: Dict[str, Any]) -> int: """Adds the total degree of the atom to the node data. diff --git a/graphein/molecule/graphs.py b/graphein/molecule/graphs.py index 76eae752..edd54632 100644 --- a/graphein/molecule/graphs.py +++ b/graphein/molecule/graphs.py @@ -16,7 +16,6 @@ import numpy as np from tqdm.contrib.concurrent import process_map, thread_map -from graphein.molecule.edges.atomic import add_atom_bonds from graphein.utils.utils import ( annotate_edge_metadata, annotate_graph_metadata, @@ -25,7 +24,11 @@ import_message, ) +from .chembl import get_smiles_from_chembl from .config import MoleculeGraphConfig +from .edges.atomic import add_atom_bonds +from .utils import compute_fragments +from .zinc import get_smiles_from_zinc log = logging.getLogger(__name__) @@ -130,13 +133,16 @@ def construct_graph( mol: Optional[rdkit.Mol] = None, path: Optional[str] = None, smiles: Optional[str] = None, + zinc_id: Optional[str] = None, + chembl_id: Optional[str] = None, + generate_conformer: Optional[bool] = False, edge_construction_funcs: Optional[str] = None, edge_annotation_funcs: Optional[List[Callable]] = None, node_annotation_funcs: Optional[List[Callable]] = None, graph_annotation_funcs: Optional[List[Callable]] = None, ) -> nx.Graph: """ - Constructs protein structure graph from a ``sdf_path``, ``mol2_path``, ``smiles`` or RDKit Mol. + Constructs molecular structure graph from a ``sdf_path``, ``mol2_path``, ``smiles`` or RDKit Mol. Users can provide a :class:`~graphein.molecule.config.MoleculeGraphConfig` object to specify construction parameters. @@ -151,6 +157,12 @@ def construct_graph( :type path: str :param smiles: smiles string to build graph from. Default is ``None``. :type smiles: str, optional + :param zinc_id: Zinc ID to build graph from. Default is ``None``. + :type zinc_id: str, optional + :param chembl_id: ChEMBL ID to build graph from. Default is ``None``. + :type chembl_id: str, optional + :param generate_conformer: Whether to generate a conformer for the molecule. Defaults to ``False``. + :type generate_conformer: bool, optional :param edge_construction_funcs: List of edge construction functions. Default is ``None``. :type edge_construction_funcs: List[Callable], optional :param edge_annotation_funcs: List of edge annotation functions. Default is ``None``. @@ -184,15 +196,21 @@ def construct_graph( ) config.edge_construction_functions = ( edge_construction_funcs - if config.edge_construction_functions is None + if edge_construction_funcs is not None else config.edge_construction_functions ) + if zinc_id is not None: + smiles = get_smiles_from_zinc(zinc_id) + + if chembl_id is not None: + smiles = get_smiles_from_chembl(chembl_id) + coords = None if smiles is not None: name = smiles rdmol = Chem.MolFromSmiles(smiles) - if config.generate_conformer: + if config.generate_conformer or generate_conformer: rdmol = generate_3d(mol=rdmol, recompute_graph=False) coords = [ list(rdmol.GetConformer(0).GetAtomPosition(idx)) @@ -225,7 +243,7 @@ def construct_graph( smiles = f.readlines()[0] name = smiles rdmol = Chem.MolFromSmiles(smiles) - if config.generate_conformer: + if config.generate_conformer or generate_conformer: rdmol = generate_3d(mol=rdmol, recompute_graph=False) coords = [ list(rdmol.GetConformer(0).GetAtomPosition(idx)) @@ -292,6 +310,28 @@ def construct_graph( return g +def compute_fragment_graphs( + g: Union[nx.Graph, Chem.Mol], config: Optional[MoleculeGraphConfig] = None +) -> List[nx.Graph]: + """Computes graphs for each fragment in a molecule. + + :param g: Input graph or molecule to fragment. + :type g: Union[nx.Graph, Chem.Mol] + :param config: Molecular graph construction config. + See: :class:`graphein.molecule.config`. Defaults to ``None``. + :type config: Optional[MoleculeGraphConfig], optional + :return: List of fragment graphs. + :rtype: List[nx.Graph] + """ + if config is None: + try: + config = g.graph["config"] + except KeyError: + config = MoleculeGraphConfig() + fragments = compute_fragments(g) + return [construct_graph(mol=m, config=config) for m in fragments] + + def _mp_graph_constructor( input: Union[str, Chem.Mol], config: MoleculeGraphConfig, @@ -310,9 +350,9 @@ def _mp_graph_constructor( :type use_file: bool :param use_smiles: Whether or not we are using SMILES strings :type use_smiles: bool - :param config: Protein structure graph construction config - :type config: ProteinGraphConfig - :return: Protein structure graph + :param config: Molecule structure graph construction config + :type config: MoleculeGraphConfig + :return: Molecule structure graph :rtype: nx.Graph """ # log.info(f"Constructing graph for: {args[0]}. Chain selection: {args[1]}") @@ -341,9 +381,9 @@ def construct_graphs_mp( return_dict: bool = True, ) -> Union[List[nx.Graph], Dict[str, nx.Graph]]: """ - Constructs protein graphs for a list of pdb codes or pdb paths using multiprocessing. + Constructs molecular graphs for a list of smiles or paths using multiprocessing. - :param pdb_code_it: List of pdb codes to use for protein graph construction + :param pdb_code_it: List of pdb codes to use for molecule graph construction :type pdb_code_it: Optional[List[str]], defaults to None :param pdb_path_it: List of paths to PDB files to use for protein graph construction :type pdb_path_it: Optional[List[str]], defaults to None diff --git a/graphein/molecule/utils.py b/graphein/molecule/utils.py new file mode 100644 index 00000000..8c209e05 --- /dev/null +++ b/graphein/molecule/utils.py @@ -0,0 +1,469 @@ +"""Utility Functions for working with Small Molecule Graphs in RDKit. + +Many of these utilities are adapted from useful_rdkit_utils (https://github.com/PatWalters/useful_rdkit_utils) by Pat Walters. + +Junction tree code adapted from Wengong Jin https://github.com/wengong-jin/icml18-jtnn +""" +# Graphein +# Author: Arian Jamasb +# License: MIT + +# Project Website: https://github.com/a-r-j/graphein +# Code Repository: https://github.com/a-r-j/graphein + +from __future__ import annotations + +import collections +from typing import Any, List, Optional, Tuple, Union + +import networkx as nx +import numpy as np +from scipy.sparse import csr_matrix +from scipy.sparse.csgraph import minimum_spanning_tree + +from graphein.utils.utils import import_message + +try: + import rdkit + from rdkit import Chem as Chem + from rdkit import DataStructs + from rdkit.Chem import AllChem + from rdkit.Chem.Descriptors import ( + TPSA, + MolLogP, + MolWt, + NumHAcceptors, + NumHDonors, + ) + from rdkit.Chem.Descriptors3D import NPR1, NPR2 + from rdkit.Chem.rdMolTransforms import ComputeCentroid +except ImportError: + import_message("graphein.molecule.utils", "rdkit", "rdkit", True) + +try: + import selfies as sf +except ImportError: + import_message("graphein.molecule.utils", "selfies", None, True) + + +MST_MAX_WEIGHT: int = 100 +MAX_NCAND: int = 2000 + + +def get_center( + mol: Union[nx.Graph, Chem.Mol], weights: Optional[np.ndarray] = None +) -> np.ndarray: + """Compute the centroid of the conformation. + + Hydrogens are ignored and no attention is paid to the difference in sizes + of the heavy atoms; however, an optional vector of weights can be passed. + + :param mol: Molecular Graph or RDkit Mol to compute the center of. + :type mol: Union[nx.Graph, Chem.Mol] + :return: The centroid of the molecule. + :rtype: np.ndarray + """ + if isinstance(mol, nx.Graph): + mol = mol.graph["rdmol"] + assert ( + mol.GetNumConformers() > 0 + ), "Molecule must have at least one conformer." + return np.array(ComputeCentroid(mol.GetConformer(0), weights=weights)) + + +def get_shape_moments(mol: Union[nx.Graph, Chem.Mol]) -> Tuple[float, float]: + """Calculate principal moments of inertia as defined in https://pubs.acs.org/doi/10.1021/ci025599w + + :param mol: Molecular Graph or RDkit Mol to compute the moments of intertia of. + :type mol: Union[nx.Graph, Chem.Mol] + :return: First 2 moments as a tuple. + :rtype: Tuple[float, float] + """ + if isinstance(mol, nx.Graph): + mol = mol.graph["rdmol"] + assert ( + mol.GetNumConformers() > 0 + ), "Molecule must have at least one conformer." + npr1 = NPR1(mol) + npr2 = NPR2(mol) + return npr1, npr2 + + +def count_fragments(mol: Union[nx.Graph, Chem.Mol]) -> int: + """Counts the number of the disconnected fragments in a molecule. + + :param mol: The molecule or molecular graph. + :type mol: Union[nx.Graph, Chem.Mol] + :return: Number of fragments. + :rtype: int + """ + if isinstance(mol, nx.Graph): + mol = mol.graph["rdmol"] + return len(Chem.GetMolFrags(mol, asMols=True)) + + +def get_max_ring_size(mol: Union[nx.Graph, Chem.Mol]) -> int: + """ + Get the size of the largest ring in a molecule. + + :param mol: Input Mol or molecular graph. + :type mol: Union[nx.Graph, Chem.Mol] + :return: size of the largest ring or 0 for an acyclic molecule. + :rtype: int + """ + if isinstance(mol, nx.Graph): + mol = mol.graph["rdmol"] + + ri = mol.GetRingInfo() + atom_rings = ri.AtomRings() + return 0 if len(atom_rings) == 0 else max(len(x) for x in ri.AtomRings()) + + +def label_rdmol_atoms( + mol: Union[nx.Graph, Chem.Mol], labels: List[Any] +) -> Union[nx.Graph, Chem.Mol]: + """Sets an atomNote label on each atom in the underlying RDKit Mol. + + :param mol: RDkit Mol or molecular graph containing a mol. + :type mol: Union[nx.Graph, Chem.Mol] + :param labels: A list of labels to set on each atom. + :type labels: _type_ + :return: _description_ + :rtype: Union[nx.Graph, Chem.Mol] + """ + if isinstance(mol, nx.Graph): + mol = mol.graph["rdmol"] + + [atm.SetProp("atomNote", "") for atm in mol.GetAtoms()] + for atm in mol.GetAtoms(): + idx = atm.GetIdx() + mol.GetAtomWithIdx(idx).SetProp("atomNote", f"{labels[idx]}") + return mol + + +def tag_rdmol_atoms( + mol, atoms_to_tag, tag: str = "x" +) -> Union[nx.Graph, Chem.Mol]: + if isinstance(mol, nx.Graph): + mol = mol.graph["rdmol"] + [atm.SetProp("atomNote", "") for atm in mol.GetAtoms()] + [mol.GetAtomWithIdx(idx).SetProp("atomNote", tag) for idx in atoms_to_tag] + return mol + + +def get_mol(smiles: str) -> rdkit.Chem.rdchem.Mol: + """ + Function for getting rdmol from smiles. Applies kekulization. + + :param smiles: smiles string to get + :type x: str + :return: rdmol + :rtype: rdkit.Chem.rdchem.Mol + """ + mol = Chem.MolFromSmiles(smiles) + if mol is None: + return None + Chem.Kekulize(mol) + return mol + + +def get_smiles(mol: Union[nx.Graph, rdkit.Chem.rdchem.Mol]) -> str: + """ + Function for getting smiles from rdmol. Applies kekulization. + + :param mol: rdmol to get + :type mol: Union[rdkit.Chem.rdchem.Mol, nx.Graph] + :return: smiles string + :rtype: str + """ + if isinstance(mol, nx.Graph): + mol = mol.graph["rdmol"] + return Chem.MolToSmiles(mol, kekuleSmiles=True) + + +def sanitize(mol: rdkit.Chem.rdchem.Mol) -> rdkit.Chem.rdchem.Mol: + """ + Function for sanitizing a rdmol + + :param mol: rdmol to sanitize + :type mol: rdkit.Chem.rdchem.Mol + :return: sanitized rdmol + :rtype: rdkit.Chem.rdchem.Mol + """ + try: + smiles = get_smiles(mol) + mol = get_mol(smiles) + except Exception as e: + return None + return mol + + +def copy_edit_mol(mol: rdkit.Chem.rdchem.Mol) -> rdkit.Chem.rdchem.Mol: + """ + Function for copying a rdmol + + :param mol: rdmol to copy + :type mol: rdkit.Chem.rdchem.Mol + :return: copied rdmol + :rtype: rdkit.Chem.rdchem.Mol + """ + new_mol = Chem.RWMol(Chem.MolFromSmiles("")) + for atom in mol.GetAtoms(): + new_atom = copy_atom(atom) + new_mol.AddAtom(new_atom) + for bond in mol.GetBonds(): + a1 = bond.GetBeginAtom().GetIdx() + a2 = bond.GetEndAtom().GetIdx() + bt = bond.GetBondType() + new_mol.AddBond(a1, a2, bt) + return new_mol + + +def get_clique_mol(mol: rdkit.Chem.rdchem.Atom, atoms: List[int]): + """ + Function for getting clique rdmol + + :param mol: rdmol to get clique + :type mol: rdkit.Chem.rdchem.Mol + :param atoms: atoms to cut + :type atoms: List[int] + :return: clique rdmol + :rtype: rdkit.Chem.rdchem.Mol + """ + smiles = Chem.MolFragmentToSmiles(mol, atoms, kekuleSmiles=True) + new_mol = Chem.MolFromSmiles(smiles, sanitize=False) + new_mol = copy_edit_mol(new_mol).GetMol() + new_mol = sanitize(new_mol) # We assume this is not None + return new_mol + + +def copy_rdmol_atom(atom: rdkit.Chem.rdchem.Atom) -> rdkit.Chem.rdchem.Atom: + """ + Function for copying an atom + + :param mol: atom to copy + :type mol: rdkit.Chem.rdchem.Atom + :return: copied atom + :rtype: rdkit.Chem.rdchem.Atom + """ + new_atom = Chem.Atom(atom.GetSymbol()) + new_atom.SetFormalCharge(atom.GetFormalCharge()) + new_atom.SetAtomMapNum(atom.GetAtomMapNum()) + return new_atom + + +def get_morgan_fp( + mol: Union[nx.Graph, rdkit.Chem.rdchem.Mol], + radius: int = 2, + n_bits: int = 20, +) -> rdkit.DataStructs.cDataStructs.ExplicitBitVect: + """ + Function for getting morgan fingerprint from an RDkit molecule or molecular graph. + + :param mol: RDKit molecule or molecular graph. + :type mol: Union[nx.Graph, rdkit.Chem.rdchem.Mol] + :param radius: Fingerprint radius. + :type radius: int + :param n_bits: Number of bits. + :type n_bits: int + :return: Morgan fingerprint. + :rtype: rdkit.Chem.rdMolDescriptors.MorganFingerprint + """ + if isinstance(mol, nx.Graph): + mol = mol.graph["rdmol"] + return AllChem.GetMorganFingerprintAsBitVect( + mol, radius=radius, nBits=n_bits + ) + + +def get_morgan_fp_np( + mol: Union[nx.Graph, rdkit.Chem.rdchem.Mol], + radius: int = 2, + n_bits: int = 20, +) -> rdkit.Chem.rdMolDescriptors.MorganFingerprint: + """ + Function for getting morgan fingerprint from an RDkit molecule or molecular graph. + + :param mol: RDKit molecule or molecular graph. + :type mol: Union[nx.Graph, rdkit.Chem.rdchem.Mol] + :param radius: Fingerprint radius. + :type radius: int + :param n_bits: Number of bits. + :type n_bits: int + :return: Morgan fingerprint. + :rtype: rdkit.Chem.rdMolDescriptors.MorganFingerprint + """ + if isinstance(mol, nx.Graph): + mol = mol.graph["rdmol"] + + arr = np.zeros((0,), dtype=np.int8) + fp = get_morgan_fp(mol=mol, radius=radius, n_bits=n_bits) + DataStructs.ConvertToNumpyArray(fp, arr) + return arr + + +def compute_fragments(mol: Union[nx.Graph, Chem.Mol]) -> List[Chem.Mol]: + if isinstance(mol, nx.Graph): + mol = mol.graph["rdmol"] + return list(Chem.GetMolFrags(mol, asMols=True)) + + +def get_mol_weight(mol: Union[nx.Graph, Chem.Mol]) -> float: + if isinstance(mol, nx.Graph): + mol = mol.graph["rdmol"] + return mol # TDOO + + +def get_qed_score( + mol: Union[nx.Graph, rdkit.Chem.rdchem.Mol] +) -> Union[float, None]: + """Computes the Quantitative Estimate of Druglikeness (QED) score for a molecule or molecular graph. + + Quantifying the chemical beauty of drugs + G. Richard Bickerton, Gaia V. Paolini, Jérémy Besnard, Sorel Muresan & Andrew L. Hopkins + Nature Chemistry volume 4, pages90–98 (2012 + + :param mol: Molecule or molecular graph. + :type mol: Union[nx.Graph, rdkit.Chem.rdchem.Mol] + :return: QED score. + :rtype: float or None if an exception is encountered + """ + if isinstance(mol, nx.Graph): + mol = mol.graph["rdmol"] + + try: + return Chem.QED.qed(mol) + except Exception as e: + # log.warning(e) + return None + + +def simplify_smile(smile: str) -> str: + """ + Simplifies a SMILE string by removing hydrogen atoms (``H``), + chiral specifications (``'@'``), charges (``+`` / ``-``), ``'#'``-characters, + and square brackets (``'['``, ``']'``). + + :param smile_str: A smile string, e.g., ``C[C@H](CCC(=O)NCCS(=O)(=O)[O-])`` + :type smile_str: str + :returns: Returns a simplified SMILE string, e.g., ``CC(CCC(=O)NCCS(=O)(=O)O)``. + :rtype: str + """ + remove_chars = ["@", "-", "+", "H", "[", "]", "#"] + stripped_smile = [] + for sym in smile: + if sym.isalpha(): + sym = sym.upper() + if sym not in remove_chars: + stripped_smile.append(sym) + return "".join(stripped_smile) + + +def smile_to_selfies(smile: str) -> str: + """Encodes a SMILES string into a Selfies string. + + :param smile: A valid SMILES string. E.g. ``"C1=CC=CC=C1"``. + :type smile: str + :return: Selfies string. E.g. ``"[C][=C][C][=C][C][=C][Ring1][=Branch1]"``. + :rtype: str + """ + return sf.encoder(smile) + + +def selfies_to_smile(selfie: str) -> str: + """Decodes a selfies string into a SMILES string. + + :param selfie: The selfies string to decode. E.g. ``"[C][=C][C][=C][C][=C][Ring1][=Branch1]"``. + :type selfie: str + :return: The decoded SMILES string. E.g. ``"C1=CC=CC=C1"``. + :rtype: str + """ + return sf.decoder(selfie) + + +def tree_decomp(mol: rdkit.Chem.rdchem.Mol) -> Tuple[List]: + """ + Function for decomposing rdmol to a tree + + :param mol: rdmol to decompose + :type mol: rdkit.Chem.rdchem.Mol + :return: decomposed cliques and edges between them + :rtype: Tuple[List] + """ + n_atoms = mol.GetNumAtoms() + if n_atoms == 1: # special case + return [[0]], [] + + cliques = [] + for bond in mol.GetBonds(): + a1 = bond.GetBeginAtom().GetIdx() + a2 = bond.GetEndAtom().GetIdx() + if not bond.IsInRing(): + cliques.append([a1, a2]) + + ssr = [list(x) for x in Chem.GetSymmSSSR(mol)] + cliques.extend(ssr) + + nei_list = [[] for _ in range(n_atoms)] + for i in range(len(cliques)): + for atom in cliques[i]: + nei_list[atom].append(i) + + # Merge Rings with intersection > 2 atoms + for i in range(len(cliques)): + if len(cliques[i]) <= 2: + continue + for atom in cliques[i]: + for j in nei_list[atom]: + if i >= j or len(cliques[j]) <= 2: + continue + inter = set(cliques[i]) & set(cliques[j]) + if len(inter) > 2: + cliques[i].extend(cliques[j]) + cliques[i] = list(set(cliques[i])) + cliques[j] = [] + + cliques = [c for c in cliques if len(c) > 0] + nei_list = [[] for _ in range(n_atoms)] + for i in range(len(cliques)): + for atom in cliques[i]: + nei_list[atom].append(i) + + # Build edges and add singleton cliques + edges = collections.defaultdict(int) + for atom in range(n_atoms): + if len(nei_list[atom]) <= 1: + continue + cnei = nei_list[atom] + bonds = [c for c in cnei if len(cliques[c]) == 2] + rings = [c for c in cnei if len(cliques[c]) > 4] + if len(bonds) > 2 or ( + len(bonds) == 2 and len(cnei) > 2 + ): # In general, if len(cnei) >= 3, a singleton should be added, but 1 bond + 2 ring is currently not dealt with. + cliques.append([atom]) + c2 = len(cliques) - 1 + for c1 in cnei: + edges[(c1, c2)] = 1 + elif len(rings) > 2: # Multiple (n>2) complex rings + cliques.append([atom]) + c2 = len(cliques) - 1 + for c1 in cnei: + edges[(c1, c2)] = MST_MAX_WEIGHT - 1 + else: + for i in range(len(cnei)): + for j in range(i + 1, len(cnei)): + c1, c2 = cnei[i], cnei[j] + inter = set(cliques[c1]) & set(cliques[c2]) + edges[(c1, c2)] = max(edges[(c1, c2)], len(inter)) + edges = [u + (MST_MAX_WEIGHT - v,) for u, v in edges.items()] + if not edges: + return cliques, edges + + # Compute Maximum Spanning Tree + row, col, data = zip(*edges) + n_clique = len(cliques) + clique_graph = csr_matrix((data, (row, col)), shape=(n_clique, n_clique)) + junc_tree = minimum_spanning_tree(clique_graph) + row, col = junc_tree.nonzero() + edges = [(row[i], col[i]) for i in range(len(row))] + return (cliques, edges) diff --git a/graphein/molecule/zinc.py b/graphein/molecule/zinc.py new file mode 100644 index 00000000..b8d71410 --- /dev/null +++ b/graphein/molecule/zinc.py @@ -0,0 +1,100 @@ +"""Utilities for retrieving molecular data from ZINC. + +Adapted from smilite (https://github.com/rasbt/smilite) by Sebastian Raschka. +""" +# Graphein +# Author: Arian Jamasb +# License: MIT + +# Project Website: https://github.com/a-r-j/graphein +# Code Repository: https://github.com/a-r-j/graphein + +import ssl +from typing import Dict, List +from urllib.error import URLError + +from tqdm.rich import tqdm + +from graphein.utils.utils import import_message + +try: + from smilite import * +except ImportError: + import_message("graphein.molecule.zinc", "smilite", "smilite", True) + + +def get_smiles_from_zinc(zinc_id: str, backend="zinc15") -> str: + """ + Gets the corresponding SMILE string for a ZINC ID query from + the ZINC online database (https://zinc.docking.org/). Requires an internet connection. + + :param zinc_id: A valid ZINC ID, e.g. ``'ZINC00029323'`` + :type zinc_id: str + :param backend: ``zinc12`` or ``zinc15`` + :type backend: str + :returns: the SMILE string for the corresponding ZINC ID. + E.g., ``'COc1cccc(c1)NC(=O)c2cccnc2'`` + :rtype: str + """ + try: + return smilite.get_zinc_smile(zinc_id, backend=backend) + except URLError: + ssl._create_default_https_context = ssl._create_unverified_context + return smilite.get_zinc_smile(zinc_id, backend=backend) + + +def get_zinc_id_from_smile(smile: str, backend: str = "zinc15") -> List[str]: + """ + Gets the corresponding ZINC ID(s) for a SMILE string query from + the ZINC online database. Requires an internet connection. + + :param smile_str: A valid SMILE string, e.g., + ``C[C@H]1CCCC[NH+]1CC#CC(c2ccccc2)(c3ccccc3)O'`` + :type smile_str: str + :param backend: Specifies the database backend, ``"zinc12"`` or ``"zinc15"``. + :type backend: str + :returns: the SMILE string for the corresponding ZINC ID(s) in a list. + E.g., ``['ZINC01234567', 'ZINC01234568', 'ZINC01242053', 'ZINC01242055']`` + :rtype: List[str] + """ + try: + return smilite.get_zincid_from_smile(smile, backend=backend) + except URLError: + ssl._create_default_https_context = ssl._create_unverified_context + return smilite.get_zincid_from_smile(smile, backend=backend) + + +def batch_get_smiles_from_zinc( + zinc_ids: List[str], backend: str = "zinc15" +) -> Dict[str, str]: + """Gets the corresponding SMILE string(s) for a list of ZINC IDs. + + :param zinc_ids: List of ZINC IDs, e.g., ``['ZINC00029323', 'ZINC00029324']`` + :type zinc_ids: List[str] + :return: _description_ + :rtype: Dict[str, str] + """ + return { + zinc_id: get_smiles_from_zinc(zinc_id, backend=backend) + for zinc_id in tqdm(zinc_ids) + } + + +def batch_get_zinc_id_from_smiles( + smiles: List[str], backend: str = "zinc15" +) -> Dict[str, List[str]]: + """ + Gets the corresponding ZINC ID for a list of smile string queries from + the ZINC online database. Requires an internet connection. + + :param smile_str: A list of valid SMILE string, e.g., + ``["C[C@H]1CCCC[NH+]1CC#CC(c2ccccc2)(c3ccccc3)O", "CCC"]`` + :type smile_str: str + :param backend: Specifies the database backend, ``"zinc12"`` or ``"zinc15"``. + :type backend: str + :returns: the SMILE string for the corresponding ZINC ID(s) in a list. + :rtype: Dict[str, List[str]] + """ + return { + s: get_zinc_id_from_smile(s, backend=backend) for s in tqdm(smiles) + } diff --git a/graphein/protein/config.py b/graphein/protein/config.py index dcfd7548..90bba527 100644 --- a/graphein/protein/config.py +++ b/graphein/protein/config.py @@ -115,7 +115,7 @@ class ProteinGraphConfig(BaseModel): residues, bound ligands, crystallographic adjuvants, ions or water molecules. For more information, see: https://proteopedia.org/wiki/index.php/Hetero_atoms - :type keep_hets: bool + :type keep_hets: List[str] :param insertions: Controls whether or not insertions are allowed. :type insertions: bool :param pdb_dir: Specifies path to download protein structures into. @@ -150,7 +150,7 @@ class ProteinGraphConfig(BaseModel): """ granularity: Union[GraphAtoms, GranularityOpts] = "CA" - keep_hets: bool = False + keep_hets: List[str] = [] insertions: bool = False pdb_dir: Optional[Path] = None verbose: bool = False diff --git a/graphein/protein/edges/distance.py b/graphein/protein/edges/distance.py index b0920c7d..1377bea8 100644 --- a/graphein/protein/edges/distance.py +++ b/graphein/protein/edges/distance.py @@ -6,6 +6,7 @@ # Code Repository: https://github.com/a-r-j/graphein from __future__ import annotations +import itertools import logging from itertools import combinations from typing import Dict, List, Optional, Tuple, Union @@ -14,8 +15,7 @@ import numpy as np import pandas as pd from scipy.spatial import Delaunay -from scipy.spatial.distance import euclidean, pdist, rogerstanimoto, squareform -from sklearn.metrics import pairwise_distances +from scipy.spatial.distance import pdist, squareform from sklearn.neighbors import kneighbors_graph from graphein.protein.resi_atoms import ( @@ -40,16 +40,25 @@ def compute_distmat(pdb_df: pd.DataFrame) -> pd.DataFrame: """ - Compute pairwise euclidean distances between every atom. + Compute pairwise Euclidean distances between every atom. - Design choice: passed in a DataFrame to enable easier testing on + Design choice: passed in a ``pd.DataFrame`` to enable easier testing on dummy data. - :param pdb_df: pd.Dataframe containing protein structure. Must contain columns ["x_coord", "y_coord", "z_coord"] + :param pdb_df: Dataframe containing protein structure. Must contain columns ``["x_coord", "y_coord", "z_coord"]``. :type pdb_df: pd.DataFrame - :return: pd.Dataframe of euclidean distance matrix + :raises: ValueError if ``pdb_df`` does not contain the required columns. + :return: pd.Dataframe of Euclidean distance matrix. :rtype: pd.DataFrame """ + if ( + not pd.Series(["x_coord", "y_coord", "z_coord"]) + .isin(pdb_df.columns) + .all() + ): + raise ValueError( + "Dataframe must contain columns ['x_coord', 'y_coord', 'z_coord']" + ) eucl_dists = pdist( pdb_df[["x_coord", "y_coord", "z_coord"]], metric="euclidean" ) @@ -60,6 +69,29 @@ def compute_distmat(pdb_df: pd.DataFrame) -> pd.DataFrame: return eucl_dists +def add_distance_to_edges(G: nx.Graph) -> nx.Graph: + """Adds Euclidean distance between nodes in an edge as an edge attribute. + + :param G: Graph to add distances to. + :type G: nx.Graph + :return: Graph with added distances. + :rtype: nx.Graph + """ + if "atomic_dist_mat" in G.graph.keys(): + dist_mat = G.graph["atomic_dist_mat"] + elif "dist_mat" in G.graph.keys(): + dist_mat = G.graph["dist_mat"] + else: + dist_mat = compute_distmat(G.graph["pdb_df"]) + G.graph["dist_mat"] = dist_mat + + mat = np.where(nx.to_numpy_matrix(G), dist_mat, 0) + node_map = {n: i for i, n in enumerate(G.nodes)} + for u, v, d in G.edges(data=True): + d["distance"] = mat[node_map[u], node_map[v]] + return G + + def add_sequence_distance_edges( G: nx.Graph, d: int, name: str = "sequence_edge" ) -> nx.Graph: @@ -68,12 +100,12 @@ def add_sequence_distance_edges( Eg. if ``d=6`` then we join: nodes ``(1,7), (2,8), (3,9)..`` based on their sequence number. - :param G: networkx protein graph. + :param G: Networkx protein graph. :type G: nx.Graph :param d: Sequence separation to add edges on. :param name: Name of the edge type. Defaults to ``"sequence_edge"``. :type name: str - :return G: networkx protein graph with added peptide bonds. + :return G: Networkx protein graph with added peptide bonds. :rtype: nx.Graph """ # Iterate over every chain @@ -124,9 +156,9 @@ def add_peptide_bonds(G: nx.Graph) -> nx.Graph: """ Adds peptide backbone as edges to residues in each chain. - :param G: networkx protein graph. + :param G: Networkx protein graph. :type G: nx.Graph - :return G: networkx protein graph with added peptide bonds. + :return G: Networkx protein graph with added peptide bonds. :rtype: nx.Graph """ return add_sequence_distance_edges(G, d=1, name="peptide_bond") @@ -392,8 +424,16 @@ def add_cation_pi_interactions( G.add_edge(resi1, resi2, kind={"cation_pi"}) -def get_interacting_atoms(angstroms: float, distmat: pd.DataFrame): - """Find the atoms that are within a particular radius of one another.""" +def get_interacting_atoms( + angstroms: float, distmat: pd.DataFrame +) -> np.ndarray: + """Find the atoms that are within a particular radius of one another. + + :param angstroms: The radius in angstroms. + :type angstroms: float + :param distmat: The distance matrix. + :type distmat: pd.DataFrame + """ return np.where(distmat <= angstroms) @@ -507,6 +547,76 @@ def add_distance_threshold( ) +def add_distance_window( + G: nx.Graph, min: float, max: float, long_interaction_threshold: int = -1 +): + """ + Adds edges to any nodes within a given window of distances of each other. Long interaction threshold is used + to specify minimum separation in sequence to add an edge between networkx nodes within the distance threshold + + :param G: Protein Structure graph to add distance edges to + :type G: nx.Graph + :param min: Minimum distance in angstroms required for an edge. + :type min: float + :param max: Maximum distance in angstroms allowed for an edge. + :param long_interaction_threshold: minimum distance in sequence for two nodes to be connected + :type long_interaction_threshold: int + :return: Graph with distance-based edges added + """ + pdb_df = filter_dataframe( + G.graph["pdb_df"], "node_id", list(G.nodes()), True + ) + dist_mat = compute_distmat(pdb_df) + # Nodes less than the minimum distance + less_than_min = get_interacting_atoms(min, distmat=dist_mat) + less_than_min = list(zip(less_than_min[0], less_than_min[1])) + + interacting_nodes = get_interacting_atoms(max, distmat=dist_mat) + interacting_nodes = list(zip(interacting_nodes[0], interacting_nodes[1])) + interacting_nodes = [ + i for i in interacting_nodes if i not in less_than_min + ] + + log.info(f"Found: {len(interacting_nodes)} distance edges") + count = 0 + for a1, a2 in interacting_nodes: + n1 = G.graph["pdb_df"].loc[a1, "node_id"] + n2 = G.graph["pdb_df"].loc[a2, "node_id"] + n1_chain = G.graph["pdb_df"].loc[a1, "chain_id"] + n2_chain = G.graph["pdb_df"].loc[a2, "chain_id"] + n1_position = G.graph["pdb_df"].loc[a1, "residue_number"] + n2_position = G.graph["pdb_df"].loc[a2, "residue_number"] + + condition_1 = n1_chain == n2_chain + condition_2 = ( + abs(n1_position - n2_position) < long_interaction_threshold + ) + + if not (condition_1 and condition_2): + count += 1 + if G.has_edge(n1, n2): + G.edges[n1, n2]["kind"].add(f"distance_window_{min}_{max}") + else: + G.add_edge(n1, n2, kind={f"distance_window_{min}_{max}"}) + log.info( + f"Added {count} distance edges. ({len(list(interacting_nodes)) - count} removed by LIN)" + ) + + +def add_fully_connected_edges(G: nx.Graph): + """ + Adds fully connected edges to nodes. + + :param G: Protein structure graph to add fully connected edges to. + :type G: nx.Graph + """ + for n1, n2 in itertools.product(G.nodes(), G.nodes()): + if G.has_edge(n1, n2): + G.edges[n1, n2]["kind"].add("fully_connected") + else: + G.add_edge(n1, n2, kind={"fully_connected"}) + + def add_k_nn_edges( G: nx.Graph, long_interaction_threshold: int, diff --git a/graphein/protein/features/graph/__init__.py b/graphein/protein/features/graph/__init__.py index e69de29b..7e7a251c 100644 --- a/graphein/protein/features/graph/__init__.py +++ b/graphein/protein/features/graph/__init__.py @@ -0,0 +1,2 @@ +from .dynamics import * +from .structure import * diff --git a/graphein/protein/features/graph/dynamics.py b/graphein/protein/features/graph/dynamics.py new file mode 100644 index 00000000..f4e8b034 --- /dev/null +++ b/graphein/protein/features/graph/dynamics.py @@ -0,0 +1,51 @@ +import networkx as nx +import numpy as np + +from graphein.utils.utils import import_message + +try: + import prody +except ImportError: + message = import_message( + "graphein.protein.features.graph.dynamics", "prody", "prody", True + ) + + +def add_modes( + g: nx.Graph, n_modes: int = 6, add_separate: bool = False +) -> nx.Graph: + """ + Computes normal modes for a protein graph. + + Normal modes are accessible with: ``g.graph["nma_eigenvectors"]``. + Normal mode eigenvalues are accessible with: ``g.graph["nma_eigenvalues"]``. + + :param g: Protein structure graph + :type g: nx.Graph + :param n_modes: Number of modes, defaults to 6 + :type n_modes: int + :return: Graph with modes added as a graph feature + :rtype: nx.Graph + """ + coords = g.graph["coords"] + anm = prody.ANM(g.graph["name"]) + anm.buildHessian(coords) + anm.calcModes() + + # eig_vecs = torch.Tensor(anm[:n_modes].getEigvecs()).reshape(-1, n_modes, 3) + eig_vals = anm[:n_modes].getEigvals() + + modes = np.array([anm[m].getArrayNx3() for m in range(n_modes)]) + modes = np.einsum("ijk->jki", modes) + + if add_separate: + for i, (_, d) in enumerate(g.nodes(data=True)): + for mode in range(n_modes): + d[f"nma_eigenvectors_{mode}"] = modes[i, :, mode] + d[f"nma_eigenvalues_{mode}"] = modes[i, :, mode] + + for i, (_, d) in enumerate(g.nodes(data=True)): + d["nma_eigenvectors"] = modes[i, :, :] + d["nma_eigenvalues"] = eig_vals + + return g diff --git a/graphein/protein/features/graph/structure.py b/graphein/protein/features/graph/structure.py new file mode 100644 index 00000000..2b3b980f --- /dev/null +++ b/graphein/protein/features/graph/structure.py @@ -0,0 +1,61 @@ +"""Functions for computing graph-level features based on structure.""" +# %% +# Graphein +# Author: Arian Jamasb +# License: MIT +# Project Website: https://github.com/a-r-j/graphein +# Code Repository: https://github.com/a-r-j/graphein +import math +from typing import Union + +import networkx as nx +import numpy as np + +from graphein.protein.resi_atoms import ATOMIC_MASSES + + +def add_radius_of_gyration(G: nx.Graph, round: bool = False) -> nx.Graph: + """Adds radius of gyration (Rg) to graph as a graph attribute (``G.graph["radius_of_gyration"]``). + + Atomic masses are defined in :ref:`graphein.protein.resi_atoms.ATOMIC_MASSES`. + + :param G: Structure graph to add radius of gyration to. + :type G: nx.Graph + :param round: Whether to round the result to the nearest integer, defaults to ``False`` + :type round: bool + :return: Graph with radius of gyration added (in angstroms). + :rtype: nx.Graph + """ + + G.graph["radius_of_gyration"] = radius_of_gyration(G, round) + return G + + +def radius_of_gyration(G: nx.Graph, round: bool = False) -> Union[float, int]: + """Calculates the radius of gyration of a structure graph in angstroms. + + Atomic masses are defined in :ref:`graphein.protein.resi_atoms.ATOMIC_MASSES`. + + :param G: Graph to calculate radius of gyration of. + :type G: nx.Graph + :param round: Whether to round the result to the nearest integer. + :type round: bool + :return: Radius of gyration in angstroms. + :rtype: float + """ + masses = [ + ATOMIC_MASSES[d["element_symbol"]] for _, d in G.nodes(data=True) + ] + total_mass = sum(masses) + + coords = [d["coords"] for _, d in G.nodes(data=True)] + weighted_coords = [coord * mass for coord, mass in zip(coords, masses)] + + rr = sum( + np.sum(w_coord * coord) + for w_coord, coord in zip(weighted_coords, coords) + ) + mm = sum((sum(w_coord) / total_mass) ** 2 for w_coord in weighted_coords) + + rg = math.sqrt(rr / total_mass - mm) + return round(rg, 3) if round else rg diff --git a/graphein/protein/features/nodes/dssp.py b/graphein/protein/features/nodes/dssp.py index cb27bd06..87eb5908 100644 --- a/graphein/protein/features/nodes/dssp.py +++ b/graphein/protein/features/nodes/dssp.py @@ -7,14 +7,14 @@ from __future__ import annotations import os -from typing import Any, Dict, Optional import tempfile +from typing import Any, Dict, Optional import networkx as nx import pandas as pd -from Bio.Data.IUPACData import protein_letters_1to3 from Bio.PDB.DSSP import dssp_dict_from_pdb_file, residue_max_acc +from graphein.protein.resi_atoms import STANDARD_AMINO_ACID_MAPPING_TO_1_3 from graphein.protein.utils import is_tool, save_pdb_df_to_pdb DSSP_COLS = [ @@ -36,17 +36,19 @@ "O_NH_2_relidx", "O_NH_2_energy", ] +"""Columns in DSSP Output.""" DSSP_SS = ["H", "B", "E", "G", "I", "T", "S"] +"""Secondary structure types detected by ``DSSP``""" def parse_dssp_df(dssp: Dict[str, Any]) -> pd.DataFrame: """ - Parse DSSP output to DataFrame + Parse ``DSSP`` output to DataFrame. - :param dssp: Dictionary containing DSSP output + :param dssp: Dictionary containing ``DSSP`` output :type dssp: Dict[str, Any] - :return: pd.Dataframe containing parsed DSSP output + :return: pd.DataFrame containing parsed ``DSSP`` output :rtype: pd.DataFrame """ appender = [] @@ -65,42 +67,12 @@ def parse_dssp_df(dssp: Dict[str, Any]) -> pd.DataFrame: return pd.DataFrame.from_records(appender, columns=DSSP_COLS) -def process_dssp_df(df: pd.DataFrame) -> pd.DataFrame: - """ - Processes a DSSP DataFrame to make indexes align with node IDs - - :param df: pd.DataFrame containing the parsed output from DSSP. - :type df: pd.DataFrame - :return: pd.DataFrame with node IDs - :rtype: pd.DataFrame - """ - - # Convert 1 letter aa code to 3 letter - amino_acids = df["aa"].tolist() - - for i, amino_acid in enumerate(amino_acids): - amino_acids[i] = protein_letters_1to3[amino_acid].upper() - df["aa"] = amino_acids - - # Construct node IDs - node_ids = [] - - for i, row in df.iterrows(): - node_id = row["chain"] + ":" + row["aa"] + ":" + str(row["resnum"]) - node_ids.append(node_id) - df["node_id"] = node_ids - - df.set_index("node_id", inplace=True) - - return df - - def add_dssp_df( G: nx.Graph, dssp_config: Optional[DSSPConfig], ) -> nx.Graph: """ - Construct DSSP dataframe and add as graph level variable to protein graph + Construct DSSP dataframe and add as graph level variable to protein graph. :param G: Input protein graph :param G: nx.Graph @@ -148,7 +120,30 @@ def add_dssp_df( print(f"Using DSSP executable '{executable}'") dssp_dict = parse_dssp_df(dssp_dict) - dssp_dict = process_dssp_df(dssp_dict) + # Convert 1 letter aa code to 3 letter + dssp_dict["aa"] = dssp_dict["aa"].map(STANDARD_AMINO_ACID_MAPPING_TO_1_3) + + # Resolve UNKs + dssp_dict.loc[dssp_dict["aa"] == "UNK", "aa"] = ( + G.graph["pdb_df"] + .loc[ + G.graph["pdb_df"].residue_number.isin( + dssp_dict.loc[dssp_dict["aa"] == "UNK"]["resnum"] + ) + ]["residue_name"] + .values + ) + + # Construct node IDs + dssp_dict["node_id"] = ( + dssp_dict["chain"] + + ":" + + dssp_dict["aa"] + + ":" + + dssp_dict["resnum"].astype(str) + ) + + dssp_dict.set_index("node_id", inplace=True) if config.verbose: print(dssp_dict) @@ -161,31 +156,31 @@ def add_dssp_df( def add_dssp_feature(G: nx.Graph, feature: str) -> nx.Graph: """ - Adds add_dssp_feature specified amino acid feature as calculated + Adds specified amino acid feature as calculated by DSSP to every node in a protein graph - :param G: Protein structure graph to add dssp feature to - :param feature: string specifying name of DSSP feature to add: - "chain", - "resnum", - "icode", - "aa", - "ss", - "asa", - "phi", - "psi", - "dssp_index", - "NH_O_1_relidx", - "NH_O_1_energy", - "O_NH_1_relidx", - "O_NH_1_energy", - "NH_O_2_relidx", - "NH_O_2_energy", - "O_NH_2_relidx", - "O_NH_2_energy", - These names parse_dssp_df accessible in the DSSP_COLS list - :param G: Protein Graph to add features to + :param G: Protein structure graph to add dssp feature to :type G: nx.Graph + :param feature: string specifying name of DSSP feature to add: + ``"chain"``, + ``"resnum"``, + ``"icode"``, + ``"aa"``, + ``"ss"``, + ``"asa"``, + ``"phi"``, + ``"psi"``, + ``"dssp_index"``, + ``"NH_O_1_relidx"``, + ``"NH_O_1_energy"``, + ``"O_NH_1_relidx"``, + ``"O_NH_1_energy"``, + ``"NH_O_2_relidx"``, + ``"NH_O_2_energy"``, + ``"O_NH_2_relidx"``, + ``"O_NH_2_energy"``, + These names are accessible in the DSSP_COLS list + :type feature: str :return: Protein structure graph with DSSP feature added to nodes :rtype: nx.Graph """ diff --git a/graphein/protein/features/sequence/sequence.py b/graphein/protein/features/sequence/sequence.py index 597ad56a..323f0c58 100644 --- a/graphein/protein/features/sequence/sequence.py +++ b/graphein/protein/features/sequence/sequence.py @@ -9,8 +9,10 @@ from __future__ import annotations from functools import partial +from typing import List, Optional import networkx as nx +import numpy as np from Bio import SeqUtils from multipledispatch import dispatch @@ -19,8 +21,6 @@ compute_feature_over_chains, ) -# from graphein.protein.features.utils import aggregate_graph_feature_over_chains - @dispatch(str, str) def molecular_weight(protein: str, seq_type: str = "protein"): @@ -36,3 +36,78 @@ def molecular_weight(protein, seq_type: str = "protein"): return compute_feature_over_chains( protein, func, feature_name="molecular_weight" ) + + +def get_sinusoid_encoding_table( + n_position: int, d_hid: int, padding_idx: Optional[int] = None +) -> np.ndarray: + """ + Numpy-based implementation of sinusoid position encoding used in Transformer models. + + Based on implementation by @foowaa (https://gist.github.com/foowaa/5b20aebd1dff19ee024b6c72e14347bb) + + :param n_position: Number of positions to encode (length of graph) (``N``). + :param d_hid: dimension of embedding vector (``M``). + :param padding_idx: Set 0 dimension. Defaults to ``None``. + :return: Sinusoid table. (``NxM``). + :rtype: np.ndarray + """ + + def calc_angle(position: int, hid_idx: int) -> float: + return position / np.power(10000, 2 * (hid_idx // 2) / d_hid) + + def get_pos_angle_vec(position: int) -> List[float]: + return [calc_angle(position, hid_j) for hid_j in range(d_hid)] + + sinusoid_table = np.array( + [get_pos_angle_vec(pos_i) for pos_i in range(n_position)] + ) + + sinusoid_table[:, 0::2] = np.sin(sinusoid_table[:, 0::2]) # dim 2i + sinusoid_table[:, 1::2] = np.cos(sinusoid_table[:, 1::2]) # dim 2i+1 + + if padding_idx is not None: + # zero vector for padding dimension + sinusoid_table[padding_idx] = 0.0 + + return sinusoid_table + + +def add_positional_encoding( + G: nx.Graph, + d_hid: int, + padding_idx: Optional[int] = None, + add_to_nodes: bool = True, +) -> nx.Graph: + """Adds transformer positional encoding (based on sequence) to graph. + + Accessed via: ``g.graph["positional_encoding"]`` if added to the graph + (``add_to_nodes=False``) or ``d["positional_encoding"] for _, d in g.nodes(data=True)`` + if added to the nodes (``add_to_nodes=True``). + + Nodes are numbered as they occur in list(g.nodes()). By default, + this corresponds to stacked N->C sequences (ie. in multichain graphs: + ``SeqA N->C, SeqB N->C, SeqC N->C``). + + :param G: Graph to add positional encoding to. + :type G: nx.Graph + :param d_hid: Dimensionality of positional encoding. + :type d_hid: int + :param padding_idx: Set 0 dimension. Defaults to ``None``. + :type padding_idx: Optional[int], optional + :param add_to_nodes: Whether to add the positional encoding to the graph as a graph-level feature + (``Nxd_hid`` matrix, where ``N`` is the length (number of nodes) of the graph), or as sliced arrays + (size ``d_hid``) added to the nodes, defaults to ``True``. + :type add_to_nodes: bool + :return: Graph with positional encoding added as either a graph feature or node features. + :rtype: nx.Graph + """ + n = len(G) + sinusoid_table = get_sinusoid_encoding_table(n, d_hid, padding_idx) + if not add_to_nodes: + G.graph["positional_encoding"] = sinusoid_table + else: + for i, (n, d) in enumerate(G.nodes(data=True)): + d["positional_encoding"] = sinusoid_table[i, :] + + return G diff --git a/graphein/protein/graphs.py b/graphein/protein/graphs.py index f5eef9e0..16931477 100644 --- a/graphein/protein/graphs.py +++ b/graphein/protein/graphs.py @@ -17,6 +17,7 @@ import pandas as pd from Bio.PDB.Polypeptide import three_to_one from biopandas.pdb import PandasPdb +from rich.progress import Progress from tqdm.contrib.concurrent import process_map from graphein.protein.config import ( @@ -24,7 +25,10 @@ GetContactsConfig, ProteinGraphConfig, ) -from graphein.protein.edges.distance import compute_distmat +from graphein.protein.edges.distance import ( + add_distance_to_edges, + compute_distmat, +) from graphein.protein.resi_atoms import BACKBONE_ATOMS, RESI_THREE_TO_1 from graphein.protein.subgraphs import extract_subgraph_from_chains from graphein.protein.utils import ( @@ -34,6 +38,7 @@ get_protein_name_from_filename, three_to_one_with_mods, ) +from graphein.rna.constants import RNA_ATOMS from graphein.utils.utils import ( annotate_edge_metadata, annotate_graph_metadata, @@ -41,15 +46,31 @@ compute_edges, ) -logging.basicConfig(level="DEBUG") +# logging.basicConfig(level="DEBUG") log = logging.getLogger(__name__) +def subset_structure_to_rna( + df: pd.DataFrame, +) -> pd.DataFrame: + """ + Return a subset of atomic dataframe that contains only certain atom names relevant for RNA structures. + + :param df: Protein Structure dataframe to subset + :type df: pd.DataFrame + :returns: Subsetted protein structure dataframe + :rtype: pd.DataFrame + """ + return filter_dataframe( + df, by_column="atom_name", list_of_values=RNA_ATOMS, boolean=True + ) + + def read_pdb_to_dataframe( pdb_path: Optional[str] = None, pdb_code: Optional[str] = None, - verbose: bool = False, - granularity: str = "CA", + uniprot_id: Optional[str] = None, + model_index: int = 1, ) -> pd.DataFrame: """ Reads PDB file to ``PandasPDB`` object. @@ -57,10 +78,14 @@ def read_pdb_to_dataframe( Returns ``atomic_df``, which is a dataframe enumerating all atoms and their cartesian coordinates in 3D space. Also contains associated metadata from the PDB file. - :param pdb_path: path to PDB file. Defaults to None. + :param pdb_path: path to PDB file. Defaults to ``None``. :type pdb_path: str, optional - :param pdb_code: 4-character PDB accession. Defaults to None. + :param pdb_code: 4-character PDB accession. Defaults to ``None``. :type pdb_code: str, optional + :param uniprot_id: UniProt ID to build graph from AlphaFoldDB. Defaults to ``None``. + :type uniprot_id: str, optional + :param model_index: Index of model to read. Only relevant for structures containing ensembles. Defaults to ``1``. + :type model_index: int, optional :param verbose: print dataframe? :type verbose: bool :param granularity: Specifies granularity of dataframe. See :class:`~graphein.protein.config.ProteinGraphConfig` for further @@ -69,35 +94,46 @@ def read_pdb_to_dataframe( :returns: ``pd.DataFrame`` containing protein structure :rtype: pd.DataFrame """ + if pdb_code is None and pdb_path is None and uniprot_id is None: + raise NameError( + "One of pdb_code, pdb_path or uniprot_id must be specified!" + ) - assert (pdb_code and not pdb_path) or (not pdb_code and pdb_path), ( - "Either a PDB ID or a path to a local PDB file" - " must be specified to read a PDB" - ) + if pdb_path is not None: + atomic_df = PandasPdb().read_pdb(pdb_path) + elif uniprot_id is not None: + atomic_df = PandasPdb().fetch_pdb( + uniprot_id=uniprot_id, source="alphafold2-v2" + ) + else: + atomic_df = PandasPdb().fetch_pdb(pdb_code) - atomic_df = ( - PandasPdb().read_pdb(pdb_path) - if pdb_path is not None - else PandasPdb().fetch_pdb(pdb_code) - ) + atomic_df = atomic_df.get_model(model_index) + if len(atomic_df.df["ATOM"]) == 0: + raise ValueError(f"No model found for index: {model_index}") + + return pd.concat([atomic_df.df["ATOM"], atomic_df.df["HETATM"]]) - # Assign Node IDs to dataframes - atomic_df.df["ATOM"]["node_id"] = ( - atomic_df.df["ATOM"]["chain_id"].apply(str) + +def label_node_id(df: pd.DataFrame, granularity: str) -> pd.DataFrame: + df["node_id"] = ( + df["chain_id"].apply(str) + ":" - + atomic_df.df["ATOM"]["residue_name"] + + df["residue_name"] + ":" - + atomic_df.df["ATOM"]["residue_number"].apply(str) + + df["residue_number"].apply(str) ) if granularity == "atom": - atomic_df.df["ATOM"]["node_id"] = ( - atomic_df.df["ATOM"]["node_id"] + df["node_id"] = df["node_id"] + ":" + df["atom_name"] + elif granularity in {"rna_atom", "rna_centroid"}: + df["node_id"] = ( + df["node_id"] + + ":" + + df["atom_number"].apply(str) + ":" - + atomic_df.df["ATOM"]["atom_name"] + + df["atom_name"] ) - if verbose: - print(atomic_df) - return atomic_df + return df def deprotonate_structure(df: pd.DataFrame) -> pd.DataFrame: @@ -193,7 +229,7 @@ def filter_hetatms( :type df: pd.DataFrame :param keep_hets: List of hetero atom names to keep. :returns: Protein structure dataframe with heteroatoms removed - :rtype pd.DataFrame + :rtype: pd.DataFrame """ return [df.loc[df["residue_name"] == hetatm] for hetatm in keep_hets] @@ -241,9 +277,20 @@ def process_dataframe( other graph construction functions. :rtype: pd.DataFrame """ + protein_df = label_node_id(protein_df, granularity=granularity) # TODO: Need to properly define what "granularity" is supposed to do. - atoms = protein_df.df["ATOM"] - hetatms = protein_df.df["HETATM"] + atoms = filter_dataframe( + protein_df, + by_column="record_name", + list_of_values=["ATOM"], + boolean=True, + ) + hetatms = filter_dataframe( + protein_df, + by_column="record_name", + list_of_values=["HETATM"], + boolean=True, + ) # This block enables processing via a list of supplied functions operating on the atom and hetatom dataframes # If these are provided, the dataframe returned will be computed only from these and the default workflow @@ -259,6 +306,10 @@ def process_dataframe( hetatms = func(hetatms) return pd.concat([atoms, hetatms]) + if keep_hets: + hetatms_to_keep = filter_hetatms(hetatms, keep_hets) + atoms = pd.concat([atoms] + hetatms_to_keep) + # Deprotonate structure by removing H atoms if deprotonate: atoms = deprotonate_structure(atoms) @@ -266,17 +317,15 @@ def process_dataframe( # Restrict DF to desired granularity if granularity == "atom": pass - elif granularity == "centroids": + elif granularity in {"centroids", "rna_centroid"}: atoms = convert_structure_to_centroids(atoms) + elif granularity == "rna_atom": + atoms = subset_structure_to_rna(atoms) else: atoms = subset_structure_to_atom_type(atoms, granularity) protein_df = atoms - if keep_hets: - hetatms_to_keep = filter_hetatms(atoms, keep_hets) - protein_df = pd.concat([atoms, hetatms_to_keep]) - # Remove alt_loc residues if not insertions: protein_df = remove_insertions(protein_df) @@ -288,9 +337,25 @@ def process_dataframe( log.debug(f"Detected {len(protein_df)} total nodes") + # Sort dataframe to place HETATMs + protein_df = sort_dataframe(protein_df) + return protein_df +def sort_dataframe(df: pd.DataFrame) -> pd.DataFrame: + """Sorts a protein dataframe by chain->residue number->atom number + + This is useful for distributing hetatms/modified residues through the DF. + + :param df: Protein dataframe to sort. + :type df: pd.DataFrame + :return: Sorted protein dataframe. + :rtype: pd.DataFrame + """ + return df.sort_values(by=["chain_id", "residue_number", "atom_number"]) + + def assign_node_id_to_dataframe( protein_df: pd.DataFrame, granularity: str ) -> pd.DataFrame: @@ -314,7 +379,7 @@ def assign_node_id_to_dataframe( + ":" + protein_df["residue_number"].apply(str) ) - if granularity == "atom": + if granularity in {"atom", "rna_atom"}: protein_df[ "node_id" ] = f'{protein_df["node_id"]}:{protein_df["atom_name"]}' @@ -377,14 +442,9 @@ def initialise_graph_with_metadata( :rtype: nx.Graph """ - assert (pdb_code and not pdb_path) or (not pdb_code and pdb_path), ( - "Either a PDB ID or a path to a local PDB file" - " must be specified to read a PDB" - ) - # Get name for graph if no name was provided - if not name: - if pdb_path: + if name is None: + if pdb_path is not None: name = get_protein_name_from_filename(pdb_path) else: name = pdb_code @@ -405,11 +465,17 @@ def initialise_graph_with_metadata( # Add Sequences to graph metadata for c in G.graph["chain_ids"]: - G.graph[f"sequence_{c}"] = ( - protein_df.loc[protein_df["chain_id"] == c]["residue_name"] - .apply(three_to_one_with_mods) - .str.cat() - ) + if granularity == "rna_atom": + sequence = protein_df.loc[protein_df["chain_id"] == c][ + "residue_name" + ].str.cat() + else: + sequence = ( + protein_df.loc[protein_df["chain_id"] == c]["residue_name"] + .apply(three_to_one_with_mods) + .str.cat() + ) + G.graph[f"sequence_{c}"] = sequence return G @@ -512,22 +578,24 @@ def compute_edges( # This control flow prevents unnecessary computation of the distance matrices if "config" in G.graph: if G.graph["config"].granularity == "atom": - G.graph["atomic_dist_mat"] = compute_distmat(G.graph["raw_pdb_df"]) + G.graph["atomic_dist_mat"] = compute_distmat(G.graph["pdb_df"]) else: G.graph["dist_mat"] = compute_distmat(G.graph["pdb_df"]) for func in funcs: func(G) - return G + return add_distance_to_edges(G) def construct_graph( config: Optional[ProteinGraphConfig] = None, name: Optional[str] = None, pdb_path: Optional[str] = None, + uniprot_id: Optional[str] = None, pdb_code: Optional[str] = None, chain_selection: str = "all", + model_index: int = 1, df_processing_funcs: Optional[List[Callable]] = None, edge_construction_funcs: Optional[List[Callable]] = None, edge_annotation_funcs: Optional[List[Callable]] = None, @@ -550,8 +618,12 @@ def construct_graph( :type pdb_path: Optional[str], defaults to ``None`` :param pdb_code: A 4-character PDB ID / accession to be used to construct the graph, if available. Default is ``None``. :type pdb_code: Optional[str], defaults to ``None`` + :param uniprot_id: UniProt accession ID to build graph from AlphaFold2DB. Default is ``None``. + :type uniprot_id: str, optional :param chain_selection: String of polypeptide chains to include in graph. E.g ``"ABDF"`` or ``"all"``. Default is ``"all"``. :type chain_selection: str + :param model_index: Index of model to use in the case of structural ensembles. Default is ``1``. + :type model_index: int :param df_processing_funcs: List of dataframe processing functions. Default is ``None``. :type df_processing_funcs: List[Callable], optional :param edge_construction_funcs: List of edge construction functions. Default is ``None``. @@ -563,83 +635,105 @@ def construct_graph( :param graph_annotation_funcs: List of graph annotation function. Default is ``None``. :type graph_annotation_funcs: List[Callable] :return: Protein Structure Graph - :type: nx.Graph + :rtype: nx.Graph """ - assert (pdb_code and not pdb_path) or (not pdb_code and pdb_path), ( - "Either a PDB ID or a path to a local PDB file" - " must be specified to construct a graph" - ) + if pdb_code is None and pdb_path is None and uniprot_id is None: + raise ValueError( + "Either a PDB ID, UniProt ID or a path to a local PDB file" + " must be specified to construct a graph" + ) # If no config is provided, use default if config is None: config = ProteinGraphConfig() + with Progress(transient=True) as progress: + task1 = progress.add_task("Reading PDB file...", total=1) + # Get name from pdb_file is no pdb_code is provided + # if pdb_path and (pdb_code is None and uniprot_id is None): + # pdb_code = get_protein_name_from_filename(pdb_path) + # pdb_code = pdb_code if len(pdb_code) == 4 else None + progress.advance(task1) + + # If config params are provided, overwrite them + config.protein_df_processing_functions = ( + df_processing_funcs + if config.protein_df_processing_functions is None + else config.protein_df_processing_functions + ) + config.edge_construction_functions = ( + edge_construction_funcs + if config.edge_construction_functions is None + else config.edge_construction_functions + ) + config.node_metadata_functions = ( + node_annotation_funcs + if config.node_metadata_functions is None + else config.node_metadata_functions + ) + config.graph_metadata_functions = ( + graph_annotation_funcs + if config.graph_metadata_functions is None + else config.graph_metadata_functions + ) + config.edge_metadata_functions = ( + edge_annotation_funcs + if config.edge_metadata_functions is None + else config.edge_metadata_functions + ) - # If config params are provided, overwrite them - config.protein_df_processing_functions = ( - df_processing_funcs - if config.protein_df_processing_functions is None - else config.protein_df_processing_functions - ) - config.edge_construction_functions = ( - edge_construction_funcs - if config.edge_construction_functions is None - else config.edge_construction_functions - ) - config.node_metadata_functions = ( - node_annotation_funcs - if config.node_metadata_functions is None - else config.node_metadata_functions - ) - config.graph_metadata_functions = ( - graph_annotation_funcs - if config.graph_metadata_functions is None - else config.graph_metadata_functions - ) - config.edge_metadata_functions = ( - edge_annotation_funcs - if config.edge_metadata_functions is None - else config.edge_metadata_functions - ) - - raw_df = read_pdb_to_dataframe( - pdb_path, - pdb_code, - verbose=config.verbose, - granularity=config.granularity, - ) - protein_df = process_dataframe( - raw_df, - chain_selection=chain_selection, - granularity=config.granularity, - insertions=config.insertions, - ) - - # Initialise graph with metadata - g = initialise_graph_with_metadata( - protein_df=protein_df, - raw_pdb_df=raw_df.df["ATOM"], - name=name, - pdb_code=pdb_code, - pdb_path=pdb_path, - granularity=config.granularity, - ) - # Add nodes to graph - g = add_nodes_to_graph(g) - - # Add config to graph - g.graph["config"] = config - - # Annotate additional node metadata - if config.node_metadata_functions is not None: - g = annotate_node_metadata(g, config.node_metadata_functions) - - # Compute graph edges - g = compute_edges( - g, - funcs=config.edge_construction_functions, - get_contacts_config=None, - ) + raw_df = read_pdb_to_dataframe( + pdb_path, + pdb_code, + uniprot_id, + model_index=model_index, + ) + task2 = progress.add_task("Processing PDB dataframe...", total=1) + # raw_df = label_node_id(raw_df, granularity=config.granularity) + # raw_df.df["ATOM"] = label_node_id( + # raw_df.df["ATOM"], granularity=config.granularity + # ) + # raw_df.df["HETATM"] = label_node_id( + # raw_df.df["HETATM"], granularity=config.granularity + # ) + raw_df = sort_dataframe(raw_df) + protein_df = process_dataframe( + raw_df, + chain_selection=chain_selection, + granularity=config.granularity, + insertions=config.insertions, + keep_hets=config.keep_hets, + ) + progress.advance(task2) + + task3 = progress.add_task("Initializing graph...", total=1) + # Initialise graph with metadata + g = initialise_graph_with_metadata( + protein_df=protein_df, + raw_pdb_df=raw_df, + name=name, + pdb_code=pdb_code, + pdb_path=pdb_path, + granularity=config.granularity, + ) + # Add nodes to graph + g = add_nodes_to_graph(g) + + # Add config to graph + g.graph["config"] = config + + # Annotate additional node metadata + if config.node_metadata_functions is not None: + g = annotate_node_metadata(g, config.node_metadata_functions) + progress.advance(task3) + task4 = progress.add_task("Constructing edges...", total=1) + # Compute graph edges + g = compute_edges( + g, + funcs=config.edge_construction_functions, + get_contacts_config=None, + ) + progress.advance(task4) # Annotate additional graph metadata if config.graph_metadata_functions is not None: @@ -653,28 +747,39 @@ def construct_graph( def _mp_graph_constructor( - args: Tuple[str, str], use_pdb_code: bool, config: ProteinGraphConfig -) -> nx.Graph: + args: Tuple[str, str, int], source: str, config: ProteinGraphConfig +) -> Union[nx.Graph, None]: """ Protein graph constructor for use in multiprocessing several protein structure graphs. - :param args: Tuple of pdb code/path and the chain selection for that PDB + :param args: Tuple of pdb code/path and the chain selection for that PDB. :type args: Tuple[str, str] - :param use_pdb_code: Whether or not we are using pdb codes or paths + :param use_pdb_code: Whether we are using ``"pdb_code"``s, ``pdb_path``s or ``"uniprot_id"``s. :type use_pdb_code: bool - :param config: Protein structure graph construction config + :param config: Protein structure graph construction config (see: :class:`graphein.protein.config.ProteinGraphConfig`). :type config: ProteinGraphConfig - :return: Protein structure graph - :rtype: nx.Graph + :return: Protein structure graph or ``None`` if an error is encountered. + :rtype: Union[nx.Graph, None] """ - log.info(f"Constructing graph for: {args[0]}. Chain selection: {args[1]}") + log.info( + f"Constructing graph for: {args[0]}. Chain selection: {args[1]}. Model index: {args[2]}" + ) func = partial(construct_graph, config=config) try: - return ( - func(pdb_code=args[0], chain_selection=args[1]) - if use_pdb_code - else func(pdb_path=args[0], chain_selection=args[1]) - ) + if source == "pdb_code": + return func( + pdb_code=args[0], chain_selection=args[1], model_index=args[2] + ) + elif source == "pdb_path": + return func( + pdb_path=args[0], chain_selection=args[1], model_index=args[2] + ) + elif source == "uniprot_id": + return func( + uniprot_id=args[0], + chain_selection=args[1], + model_index=args[2], + ) except Exception as ex: log.info( @@ -687,7 +792,9 @@ def _mp_graph_constructor( def construct_graphs_mp( pdb_code_it: Optional[List[str]] = None, pdb_path_it: Optional[List[str]] = None, - chain_selections: Optional[list[str]] = None, + uniprot_id_it: Optional[List[str]] = None, + chain_selections: Optional[List[str]] = None, + model_indices: Optional[List[str]] = None, config: ProteinGraphConfig = ProteinGraphConfig(), num_cores: int = 16, return_dict: bool = True, @@ -702,6 +809,8 @@ def construct_graphs_mp( :type pdb_path_it: Optional[List[str]], defaults to ``None`` :param chain_selections: List of chains to select from the protein structures (e.g. ``["ABC", "A", "L", "CD"...]``) :type chain_selections: Optional[List[str]], defaults to ``None`` + :param model_indices: List of model indices to use for protein graph construction. Only relevant for structures containing ensembles of models. + :type model_indices: Optional[List[str]], defaults to ``None`` :param config: ProteinGraphConfig to use. :type config: graphein.protein.config.ProteinGraphConfig, defaults to default config params :param num_cores: Number of cores to use for multiprocessing. The more the merrier @@ -715,27 +824,35 @@ def construct_graphs_mp( """ assert ( pdb_code_it is not None or pdb_path_it is not None - ), "Iterable of pdb codes OR pdb paths required." + ), "Iterable of pdb codes, pdb paths or uniprot IDs required." if pdb_code_it is not None: pdbs = pdb_code_it - use_pdb_code = True + source = "pdb_code" if pdb_path_it is not None: pdbs = pdb_path_it - use_pdb_code = False + source = "pdb_path" + + if uniprot_id_it is not None: + pdbs = uniprot_id_it + source = "uniprot_id" if chain_selections is None: chain_selections = ["all"] * len(pdbs) - constructor = partial( - _mp_graph_constructor, use_pdb_code=use_pdb_code, config=config - ) + if model_indices is None: + model_indices = [1] * len(pdbs) + + constructor = partial(_mp_graph_constructor, source=source, config=config) graphs = list( process_map( constructor, - [(pdb, chain_selections[i]) for i, pdb in enumerate(pdbs)], + [ + (pdb, chain_selections[i], model_indices[i]) + for i, pdb in enumerate(pdbs) + ], max_workers=num_cores, ) ) @@ -966,3 +1083,42 @@ def compute_secondary_structure_graph( if return_weighted_graph: return compute_weighted_graph_from_multigraph(h) return h + + +def compute_line_graph(g: nx.Graph, repopulate_data: bool = True) -> nx.Graph: + """Computes the line graph of a graph. + + The line graph of a graph G has a node for each edge in G and an edge + joining those nodes if the two edges in G share a common node. For directed + graphs, nodes are adjacent exactly when the edges they represent form a + directed path of length two. + + The nodes of the line graph are 2-tuples of nodes in the original graph (or + 3-tuples for multigraphs, with the key of the edge as the third element). + + :param g: Graph to compute the line graph of. + :type g: nx.Graph + :param repopulate_data: Whether or not to map node and edge data to edges + and nodes of the line graph, defaults to True + :type repopulate_data: bool, optional + :return: Line graph of g. + :rtype: nx.Graph + """ + l_g = nx.generators.line_graph(g) + l_g.graph = g.graph + + if repopulate_data: + source_edge_data = {(u, v): d for u, v, d in g.edges(data=True)} + nx.set_node_attributes(l_g, source_edge_data) + + node_list = {} + for u, v, d in l_g.edges(data=True): + node_union = u + v + for n in node_union: + if node_union.count(n) > 1: + node_list[(u, v)] = n + break + + source_node_data = {k: g.nodes[v] for k, v in node_list.items()} + nx.set_edge_attributes(l_g, source_node_data) + return l_g diff --git a/graphein/protein/meshes.py b/graphein/protein/meshes.py index b89f596e..28c6e70b 100644 --- a/graphein/protein/meshes.py +++ b/graphein/protein/meshes.py @@ -7,18 +7,16 @@ from __future__ import annotations import importlib.util -import logging import os import time from typing import List, NamedTuple, Optional, Tuple +from loguru import logger as log + from graphein.protein.config import ProteinMeshConfig from graphein.utils.pymol import MolViewer from graphein.utils.utils import import_message -log = logging.getLogger(__name__) - - try: from pytorch3d.structures import Meshes except ImportError: diff --git a/graphein/protein/resi_atoms.py b/graphein/protein/resi_atoms.py index 9acef988..2c3d0f22 100644 --- a/graphein/protein/resi_atoms.py +++ b/graphein/protein/resi_atoms.py @@ -111,13 +111,45 @@ "Z", ] """Vocabulary of amino acids with one-letter codes. Includes `fuzzy` standard amino acids: -``"B"`` denotes ``"ASX"`` which corresponds to ``"ASP"`` (``"D"``) **or** ``"ASN"`` (``"N"``) +``"B"`` denotes ``"ASX"`` which corresponds to ``"ASP"`` (``"D"``) **or** ``"ASN"`` (``"N"``), +``"J"`` denotes ``"XLE"`` which corresponds to ``"LEU"`` (``"L"``) **or** ``"ILE"`` (``"I"``), and ``"Z"`` denotes ``"GLX"`` which corresponds to``"GLU"`` (``"E"``) **or** ``"GLN"`` (``"Q"``). +``"X"`` denotes unknown (``"UNK"`` or sometimes ``"XAA"``). """ +STANDARD_AMINO_ACID_MAPPING_TO_1_3: Dict[str, str] = { + "A": "ALA", + "C": "CYS", + "D": "ASP", + "E": "GLU", + "F": "PHE", + "G": "GLY", + "H": "HIS", + "I": "ILE", + "K": "LYS", + "L": "LEU", + "M": "MET", + "N": "ASN", + "O": "PYL", + "P": "PRO", + "Q": "GLN", + "R": "ARG", + "S": "SER", + "T": "THR", + "U": "SEC", + "V": "VAL", + "W": "TRP", + "Y": "TYR", + "X": "UNK", +} + NON_STANDARD_AMINO_ACID_MAPPING_3_TO_1: Dict[str, str] = { - "SEC": "U", + "CGU": "E", + "HID": "H", + "HIE": "H", + "HIP": "H", "PYL": "O", + "SEC": "U", } """ Mapping of 3-letter non-standard amino acids codes to their one-letter form. @@ -140,28 +172,28 @@ STANDARD_RESI_NAMES: List[str] = [ "ALA", + "ARG", + "ASN", + "ASP", "ASX", "CYS", - "ASP", + "GLN", "GLU", - "PHE", + "GLX", "GLY", "HIS", "ILE", - "LYS", "LEU", + "LYS", "MET", - "ASN", + "PHE", "PRO", - "GLN", - "ARG", "SER", "THR", - "VAL", "TRP", "TYR", - "GLX", "UNK", + "VAL", ] """ List of standard residue 3-letter names. @@ -170,23 +202,26 @@ """ NON_STANDARD_RESI_NAMES: List[str] = [ - "CSD", - "HYP", - "BMT", "5HP", - "ACE", "ABA", + "ACE", "AIB", - "NH2", + "BMT", + "BOC", "CBX", + "CEA", + "CGU", + "CME", + "CRO", + "CSD", + "CSO", + "CSS", "CSW", - "OCS", + "CSX", + "CXM", "DAL", "DAR", - "DSG", - "DSP", "DCY", - "CRO", "DGL", "DGN", "DHI", @@ -196,39 +231,39 @@ "DLY", "DPN", "DPR", + "DSG", "DSN", + "DSP", "DTH", "DTR", "DTY", "DVA", + "FME", "FOR", - "CGU", + "HID", + "HIE", + "HIP", + "HYP", "IVA", "KCX", "LLP", - "CXM", - "FME", "MLE", "MVA", + "NH2", "NLE", - "PTR", + "OCS", "ORN", - "SEP", - "SEC", - "TPO", "PCA", + "PTR", "PVL", "PYL", "SAR", - "CEA", - "CSO", - "CSS", - "CSX", - "CME", - "TYS", - "BOC", - "TPQ", + "SEC", + "SEP", "STY", + "TPO", + "TPQ", + "TYS", ] """ List of non-standard residue 3-letter names. @@ -237,45 +272,32 @@ """ RESI_NAMES: List[str] = [ - "ALA", - "ASX", - "CYS", - "ASP", - "GLU", - "PHE", - "GLY", - "HIS", - "ILE", - "LYS", - "LEU", - "MET", - "ASN", - "PRO", - "GLN", - "ARG", - "SER", - "THR", - "VAL", - "TRP", - "TYR", - "GLX", - "CSD", - "HYP", - "BMT", "5HP", - "ACE", "ABA", + "ACE", "AIB", - "NH2", + "ALA", + "ARG", + "ASN", + "ASP", + "ASX", + "BMT", + "BOC", "CBX", + "CEA", + "CGU", + "CME", + "CRO", + "CSD", + "CSO", + "CSS", "CSW", - "OCS", + "CSX", + "CXM", + "CYS", "DAL", "DAR", - "DSG", - "DSP", "DCY", - "CRO", "DGL", "DGN", "DHI", @@ -285,40 +307,56 @@ "DLY", "DPN", "DPR", + "DSG", "DSN", + "DSP", "DTH", "DTR", "DTY", "DVA", + "FME", "FOR", - "CGU", + "GLN", + "GLU", + "GLX", + "GLY", + "HID", + "HIE", + "HIP", + "HIS", + "HYP", + "ILE", "IVA", "KCX", + "LEU", "LLP", - "CXM", - "FME", + "LYS", + "MET", "MLE", "MVA", + "NH2", "NLE", - "PTR", + "OCS", "ORN", - "SEP", - "SEC", - "TPO", "PCA", + "PHE", + "PRO", + "PTR", "PVL", "PYL", "SAR", - "CEA", - "CSO", - "CSS", - "CSX", - "CME", - "TYS", - "BOC", - "TPQ", + "SEC", + "SEP", + "SER", "STY", + "THR", + "TPO", + "TPQ", + "TRP", + "TYR", + "TYS", "UNK", + "VAL", ] """ 3-letter residue names for all amino acids. @@ -328,47 +366,34 @@ # https://www.ebi.ac.uk/pdbe-srv/pdbechem/chemicalCompound RESI_THREE_TO_1: Dict[str, str] = { - "ALA": "A", - "ASX": "B", - "CYS": "C", - "ASP": "D", - "GLU": "E", - "PHE": "F", - "GLY": "G", - "HIS": "H", - "ILE": "I", - "LYS": "K", - "LEU": "L", - "MET": "M", - "ASN": "N", - "PRO": "P", - "GLN": "Q", - "ARG": "R", - "SER": "S", - "THR": "T", - "VAL": "V", - "TRP": "W", - "TYR": "Y", - "GLX": "Z", - "CSD": "C", - "HYP": "P", - "BMT": "T", "3HP": "X", "4HP": "X", "5HP": "Q", - "ACE": "X", "ABA": "A", + "ACE": "X", "AIB": "A", - "NH2": "X", + "ALA": "A", + "ARG": "R", + "ASN": "N", + "ASP": "D", + "ASX": "B", + "BMT": "T", + "BOC": "X", "CBX": "X", + "CEA": "C", + "CGU": "E", + "CME": "C", + "CRO": "TYG", + "CSD": "C", + "CSO": "C", + "CSS": "C", "CSW": "C", - "OCS": "C", + "CSX": "C", + "CXM": "M", + "CYS": "C", "DAL": "A", "DAR": "R", - "DSG": "N", - "DSP": "D", "DCY": "C", - "CRO": "TYG", "DGL": "E", "DGN": "Q", "DHI": "H", @@ -378,40 +403,56 @@ "DLY": "K", "DPN": "F", "DPR": "P", + "DSG": "N", "DSN": "S", + "DSP": "D", "DTH": "T", "DTR": "W", "DTY": "Y", "DVA": "V", + "FME": "M", "FOR": "X", - "CGU": "E", + "GLN": "Q", + "GLU": "E", + "GLX": "Z", + "GLY": "G", + "HID": "H", # Different protonation states of HIS + "HIE": "H", # Different protonation states of HIS + "HIP": "H", # Different protonation states of HIS + "HIS": "H", + "HYP": "P", + "ILE": "I", "IVA": "X", "KCX": "K", + "LEU": "L", "LLP": "K", - "CXM": "M", - "FME": "M", + "LYS": "K", + "MET": "M", "MLE": "L", "MVA": "V", + "NH2": "X", "NLE": "L", - "PTR": "Y", + "OCS": "C", "ORN": "A", - "SEP": "S", - "SEC": "U", - "TPO": "T", "PCA": "Q", + "PHE": "F", + "PRO": "P", + "PTR": "Y", "PVL": "X", "PYL": "O", "SAR": "G", - "CEA": "C", - "CSO": "C", - "CSS": "C", - "CSX": "C", - "CME": "C", - "TYS": "Y", - "BOC": "X", - "TPQ": "Y", + "SEC": "U", + "SEP": "S", + "SER": "S", "STY": "Y", + "THR": "T", + "TPO": "T", + "TPQ": "Y", + "TRP": "W", + "TYR": "Y", + "TYS": "Y", "UNK": "X", + "VAL": "V", } """ Mapping of 3-letter residue names to 1-letter residue names. @@ -484,23 +525,26 @@ """ NON_STANDARD_RESIS_PARENT: Dict[str, str] = { - "CSD": "CYS", - "HYP": "PRO", - "BMT": "THR", "5HP": "GLU", - "ACE": "-", "ABA": "ALA", + "ACE": "-", "AIB": "ALA", - "NH2": "-", + "BMT": "THR", + "BOC": "-", "CBX": "-", + "CEA": "CYS", + "CGU": "GLU", + "CME": "CYS", + "CRO": "CRO", + "CSD": "CYS", + "CSO": "CYS", + "CSS": "CYS", "CSW": "CYS", - "OCS": "CYS", + "CSX": "CYS", + "CXM": "MET", "DAL": "ALA", "DAR": "ARG", - "DSG": "ASN", - "DSP": "ASP", "DCY": "CYS", - "CRO": "CRO", "DGL": "GLU", "DGN": "GLN", "DHI": "HIS", @@ -510,39 +554,36 @@ "DLY": "LYS", "DPN": "PHE", "DPR": "PRO", + "DSG": "ASN", "DSN": "SER", + "DSP": "ASP", "DTH": "THR", "DTR": "DTR", "DTY": "TYR", "DVA": "VAL", + "FME": "MET", "FOR": "-", - "CGU": "GLU", + "HYP": "PRO", "IVA": "-", "KCX": "LYS", "LLP": "LYS", - "PYL": "LYS", - "CXM": "MET", - "FME": "MET", "MLE": "LEU", "MVA": "VAL", + "NH2": "-", "NLE": "LEU", - "PTR": "TYR", + "OCS": "CYS", "ORN": "ALA", - "SEP": "SER", - "TPO": "THR", "PCA": "GLU", + "PTR": "TYR", "PVL": "-", + "PYL": "LYS", "SAR": "GLY", - "CEA": "CYS", - "CSO": "CYS", - "CSS": "CYS", - "CSX": "CYS", - "CME": "CYS", "SEC": "CYS", - "TYS": "TYR", - "BOC": "-", - "TPQ": "PHE", + "SEP": "SER", "STY": "TYR", + "TPO": "THR", + "TPQ": "PHE", + "TYS": "TYR", } """ Mapping of 3-letter non-standard/modified residues to their 3-letter parent residue names. @@ -642,14 +683,14 @@ """ CARBOHYDRATE_NAMES: List[str] = [ + "D-GALACTOSE", "D-GLUCOSE", "D-MANNOSE", + "D-XYLOPYRANOSE", "FUCOSE", - "D-GALACTOSE", - "N-ACETYL-D-GLUCOSAMINE", "N-ACETYL-D-GALACTOSAMINE", + "N-ACETYL-D-GLUCOSAMINE", "O-SIALIC_ACID", - "D-XYLOPYRANOSE", ] """ Names of commonly found carbohydrates in protein structures. @@ -659,12 +700,12 @@ CARBOHYDRATE_CODES: List[str] = [ "BGC", - "GLC", - "MAN", "BMA", "FUC", "GAL", "GLA", + "GLC", + "MAN", "NAG", "NGA", "SIA", @@ -678,12 +719,12 @@ CARBOHYDRATE_CODE_NAME_MAPPING: Dict[str, str] = { "BGC": "D-GLUCOSE", - "GLC": "D-GLUCOSE", - "MAN": "D-MANNOSE", "BMA": "D-MANNOSE", "FUC": "FUCOSE", "GAL": "D-GALACTOSE", "GLA": "D-GALACTOSE", + "GLC": "D-GLUCOSE", + "MAN": "D-MANNOSE", "NAG": "N-ACETYL-D-GLUCOSAMINE", "NGA": "N-ACETYL-D-GALACTOSAMINE", "SIA": "O-SIALIC_ACID", @@ -697,14 +738,14 @@ HYDROPHOBIC_RESIS: List[str] = [ "ALA", - "VAL", - "LEU", "ILE", + "LEU", "MET", "PHE", - "TRP", "PRO", + "TRP", "TYR", + "VAL", ] """List of residues that are considered to be hydrophobic.""" @@ -724,9 +765,9 @@ """Negatively charged amino acids.""" AA_RING_ATOMS: Dict[str, List[str]] = { + "HIS": ["CG", "CD", "CE", "ND", "NE"], "PHE": ["CG", "CD", "CE", "CZ"], "TRP": ["CD", "CE", "CH", "CZ"], - "HIS": ["CG", "CD", "CE", "ND", "NE"], "TYR": ["CG", "CD", "CE", "CZ"], } """ @@ -753,9 +794,11 @@ "ARG": 10.76, "ASN": 10.76, "ASP": 2.98, + "ASX": 6.87, # the average of D and N "CYS": 5.02, - "GLU": 3.08, "GLN": 5.65, + "GLU": 3.08, + "GLX": 4.35, # the average of E and Q "GLY": 6.06, "HIS": 7.64, "ILE": 6.04, @@ -768,10 +811,8 @@ "THR": 5.60, "TRP": 5.88, "TYR": 5.63, - "VAL": 6.02, "UNK": 7.00, # unknown so assign neutral - "ASX": 6.87, # the average of D and N - "GLX": 4.35, # the average of E and Q + "VAL": 6.02, } """ Dictionary of isoelectric points for standard amino acids. For ``"UNK"`` residues, neutral (pH 7.0) is assigned. @@ -797,9 +838,11 @@ "ARG": 174.2017, "ASN": 132.1184, "ASP": 133.1032, + "ASX": 132.6108, # the average of D and N "CYS": 121.1590, - "GLU": 147.1299, "GLN": 146.1451, + "GLU": 147.1299, + "GLX": 146.6375, # the average of E and Q "GLY": 75.0669, "HIS": 155.1552, "ILE": 131.1736, @@ -812,12 +855,10 @@ "THR": 119.1197, "TRP": 204.2262, "TYR": 181.1894, - "VAL": 117.1469, "UNK": 137.1484, # unknown, therefore assign average of knowns - "ASX": 132.6108, # the average of D and N - "GLX": 146.6375, # the average of E and Q + "VAL": 117.1469, } -"""Mapping of 3-letter amino acid names to molecular weights. +"""Mapping of 3-letter amino acid names to molecular weights. ``UNK`` is used for unknown residues and takes the mean of known weights. For ``"ASX"`` and ``"GLX"`` the average of their constituents (``"D"`` and ``"N"``, and ``"E"`` and ``"Q"``, respectively) is assigned. """ @@ -828,7 +869,7 @@ for k, v in MOLECULAR_WEIGHTS.items() } """ -Standardized (sklearn.StandardScaler) molecular weights for standard amino acids. +Standardized (sklearn.StandardScaler) molecular weights for standard amino acids. See :const:`~graphein.protein.resi_atoms.MOLECULAR_WEIGHTS` for details. """ @@ -1914,3 +1955,13 @@ Jon C. Baber and Edward E. Hodgkin* J. Chem. Inf. Comput. Sci. 1992, 32. 401-406 """ + +ATOMIC_MASSES: Dict[str, float] = { + "C": 12.0107, + "H": 1.00794, + "O": 15.9994, + "N": 14.0067, + "P": 30.9738, + "S": 32.065, +} +"""Dictionary of atomic masses for standard protein elements.""" diff --git a/graphein/protein/subgraphs.py b/graphein/protein/subgraphs.py index 408d3524..51ae75a7 100644 --- a/graphein/protein/subgraphs.py +++ b/graphein/protein/subgraphs.py @@ -32,15 +32,15 @@ def extract_subgraph_from_node_list( :type g: nx.Graph :param node_list: The list of nodes to extract. :type node_list: List[str] - :param filter_dataframe: Whether to filter the pdb_df dataframe of the graph. Defaults to True. + :param filter_dataframe: Whether to filter the ``pdb_df`` dataframe of the graph. Defaults to ``True``. :type filter_dataframe: bool - :param update_coords: Whether to update the coordinates of the graph. Defaults to True. + :param update_coords: Whether to update the coordinates of the graph. Defaults to ``True``. :type update_coords: bool - :param recompute_distmat: Whether to recompute the distance matrix of the graph. Defaults to False. + :param recompute_distmat: Whether to recompute the distance matrix of the graph. Defaults to ``False``. :type recompute_distmat: bool - :param inverse: Whether to inverse the selection. Defaults to False. + :param inverse: Whether to inverse the selection. Defaults to ``False``. :type inverse: bool - :return: The subgraph or node list if return_node_list is True. + :return: The subgraph or node list if ``return_node_list=True``. :rtype: Union[nx.Graph, List[str]] """ if node_list: @@ -54,7 +54,7 @@ def extract_subgraph_from_node_list( log.debug(f"Creating subgraph from nodes: {node_list}.") # Create a subgraph from the node list. - g = g.subgraph(node_list) + g = g.subgraph(node_list).copy() # Filter the PDB DF accordingly if filter_dataframe: g.graph["pdb_df"] = g.graph["pdb_df"].loc[ @@ -68,6 +68,9 @@ def extract_subgraph_from_node_list( if not filter_dataframe: log.warning("Recomputing distmat without filtering dataframe.") g.graph["dist_mat"] = compute_distmat(g.graph["pdb_df"]) + # Reset numbering for edge funcs + g.graph["pdb_df"] = g.graph["pdb_df"].reset_index(drop=True) + if return_node_list: return node_list @@ -92,15 +95,15 @@ def extract_subgraph_from_point( :type centre_point: Tuple[float, float, float] :param radius: The radius of the subgraph. :type radius: float - :param filter_dataframe: Whether to filter the pdb_df dataframe of the graph. Defaults to True. + :param filter_dataframe: Whether to filter the pdb_df dataframe of the graph. Defaults to ``True``. :type filter_dataframe: bool - :param update_coords: Whether to update the coordinates of the graph. Defaults to True. + :param update_coords: Whether to update the coordinates of the graph. Defaults to ``True``. :type update_coords: bool - :param recompute_distmat: Whether to recompute the distance matrix of the graph. Defaults to False. + :param recompute_distmat: Whether to recompute the distance matrix of the graph. Defaults to ``False``. :type recompute_distmat: bool - :param inverse: Whether to inverse the selection. Defaults to False. + :param inverse: Whether to inverse the selection. Defaults to ``False``. :type inverse: bool - :return: The subgraph or node list if return_node_list is True. + :return: The subgraph or node list if ``return_node_list=True``. :rtype: Union[nx.Graph, List[str]] """ node_list: List = [] @@ -142,15 +145,15 @@ def extract_subgraph_from_atom_types( :type g: nx.Graph :param atom_types: The list of atom types to extract. :type atom_types: List[str] - :param filter_dataframe: Whether to filter the pdb_df dataframe of the graph. Defaults to True. + :param filter_dataframe: Whether to filter the ``pdb_df`` dataframe of the graph. Defaults to ``True``. :type filter_dataframe: bool - :param update_coords: Whether to update the coordinates of the graph. Defaults to True. + :param update_coords: Whether to update the coordinates of the graph. Defaults to ``True``. :type update_coords: bool - :param recompute_distmat: Whether to recompute the distance matrix of the graph. Defaults to False. + :param recompute_distmat: Whether to recompute the distance matrix of the graph. Defaults to ``False``. :type recompute_distmat: bool - :param inverse: Whether to inverse the selection. Defaults to False. + :param inverse: Whether to inverse the selection. Defaults to ``False``. :type inverse: bool - :return: The subgraph or node list if return_node_list is True. + :return: The subgraph or node list if ``return_node_list=True``. :rtype: Union[nx.Graph, List[str]] """ node_list: List = [ @@ -184,17 +187,17 @@ def extract_subgraph_from_residue_types( :param g: The graph to extract the subgraph from. :type g: nx.Graph - :param residue_types: List of allowable residue types (3 letter residue names). + :param residue_types: List of allowable residue types (3 letter residue names). E.g. ``["SER", "GLY", "ALA"]`` :type residue_types: List[str] - :param filter_dataframe: Whether to filer the pdb_df of the graph, defaults to True + :param filter_dataframe: Whether to filer the pdb_df of the graph, defaults to ``True`` :type filter_dataframe: bool, optional - :param update_coords: Whether to update the coordinates of the graph. Defaults to True. + :param update_coords: Whether to update the coordinates of the graph. Defaults to ``True``. :type update_coords: bool - :param recompute_distmat: Whether to recompute the distance matrix of the graph. Defaults to False. + :param recompute_distmat: Whether to recompute the distance matrix of the graph. Defaults to ``False``. :type recompute_distmat: bool - :param inverse: Whether to inverse the selection. Defaults to False. + :param inverse: Whether to inverse the selection. Defaults to ``False``. :type inverse: bool - :return: The subgraph or node list if return_node_list is True. + :return: The subgraph or node list if ``return_node_list=True``. :rtype: Union[nx.Graph, List[str]] """ node_list: List = [ @@ -228,17 +231,17 @@ def extract_subgraph_from_chains( :param g: The graph to extract the subgraph from. :type g: nx.Graph - :param chain: The chain(s) to extract. + :param chain: The chain(s) to extract. E.g. ``["A", "C", "E"]`` or ``["A"]``. :type chain: List[str] - :param filter_dataframe: Whether to filter the pdb_df dataframe of the graph. Defaults to True. + :param filter_dataframe: Whether to filter the ``pdb_df`` dataframe of the graph. Defaults to ``True``. :type filter_dataframe: bool - :param update_coords: Whether to update the coordinates of the graph. Defaults to True. + :param update_coords: Whether to update the coordinates of the graph. Defaults to ``True``. :type update_coords: bool - :param recompute_distmat: Whether to recompute the distance matrix of the graph. Defaults to False. + :param recompute_distmat: Whether to recompute the distance matrix of the graph. Defaults to ``False``. :type recompute_distmat: bool - :param inverse: Whether to inverse the selection. Defaults to False. + :param inverse: Whether to inverse the selection. Defaults to ``False``. :type inverse: bool - :return: The subgraph or node list if return_node_list is True. + :return: The subgraph or node list if ``return_node_list=True``. :rtype: Union[nx.Graph, List[str]] """ node_list: List = [ @@ -267,21 +270,21 @@ def extract_subgraph_by_sequence_position( inverse: bool = False, return_node_list: bool = False, ) -> Union[nx.Graph, List[str]]: - """Extracts a subgraph from a graph based on a chain. + """Extracts a subgraph from a graph based on position in the sequence :param g: The graph to extract the subgraph from. :type g: nx.Graph - :param chain: The sequence positions to extract. + :param chain: The sequence positions to extract. E.g. ``[1, 2, 3]`` or ``[1]``. :type chain: List[int] - :param filter_dataframe: Whether to filter the pdb_df dataframe of the graph. Defaults to True. + :param filter_dataframe: Whether to filter the ``pdb_df`` dataframe of the graph. Defaults to ``True``. :type filter_dataframe: bool - :param update_coords: Whether to update the coordinates of the graph. Defaults to True. + :param update_coords: Whether to update the coordinates of the graph. Defaults to ``True``. :type update_coords: bool - :param recompute_distmat: Whether to recompute the distance matrix of the graph. Defaults to False. + :param recompute_distmat: Whether to recompute the distance matrix of the graph. Defaults to ``False``. :type recompute_distmat: bool - :param inverse: Whether to inverse the selection. Defaults to False. + :param inverse: Whether to inverse the selection. Defaults to ``False``. :type inverse: bool - :return: The subgraph or node list if return_node_list is True. + :return: The subgraph or node list if ``return_node_list=True``. :rtype: Union[nx.Graph, List[str]] """ node_list: List = [ @@ -318,19 +321,19 @@ def extract_subgraph_by_bond_type( :param g: The graph to extract the subgraph from. :type g: nx.Graph - :param bond_types: List of allowable bond types. + :param bond_types: List of allowable bond types. E.g. ``["hydrogen_bond", "k_nn_3"]`` :type bond_types: List[str] - :param filter_dataframe: Whether to filter the pdb_df of the graph, defaults to True + :param filter_dataframe: Whether to filter the ``pdb_df`` of the graph, defaults to ``True``. :type filter_dataframe: bool, optional - :param update_coords: Whether to update the coordinates of the graph. Defaults to True. + :param update_coords: Whether to update the coordinates of the graph. Defaults to ``True``. :type update_coords: bool - :param recompute_distmat: Whether to recompute the distance matrix of the graph. Defaults to False. + :param recompute_distmat: Whether to recompute the distance matrix of the graph. Defaults to ``False``. :type recompute_distmat: bool - :param inverse: Whether to inverse the selection, defaults to False + :param inverse: Whether to inverse the selection, defaults to ``False``. :type inverse: bool, optional - :param return_node_list: Whether to return the node list, defaults to False + :param return_node_list: Whether to return the node list, defaults to ``False``. :type return_node_list: bool, optional - :return: The subgraph or node list if return_node_list is True. + :return: The subgraph or node list if ``return_node_list=True``. :rtype: Union[nx.Graph, List[str]] """ @@ -378,19 +381,19 @@ def extract_subgraph_from_secondary_structure( :param g: The graph to extract the subgraph from. :type g: nx.Graph - :param ss_elements: List of secondary structure elements to extract. + :param ss_elements: List of secondary structure elements to extract. E.g. ``["H", "E"]`` :type ss_elements: List[str] - :param inverse: Whether to inverse the selection. Defaults to False. + :param inverse: Whether to inverse the selection. Defaults to ``False``. :type inverse: bool - :param filter_dataframe: Whether to filter the pdb_df of the graph, defaults to True + :param filter_dataframe: Whether to filter the ``pdb_df`` of the graph, defaults to ``True``. :type filter_dataframe: bool, optional - :param recompute_distmat: Whether to recompute the distance matrix of the graph. Defaults to False. + :param recompute_distmat: Whether to recompute the distance matrix of the graph. Defaults to ``False``. :type recompute_distmat: bool - :param update_coords: Whether to update the coordinates of the graph. Defaults to True. + :param update_coords: Whether to update the coordinates of the graph. Defaults to ``True``. :type update_coords: bool - :param return_node_list: Whether to return the node list. Defaults to False. - :raises ProteinGraphConfigurationError: If the graph does not contain ss features on the nodes (`d['ss'] not in d.keys() for _, d in g.nodes(data=True)`). - :return: The subgraph or node list if return_node_list is True. + :param return_node_list: Whether to return the node list. Defaults to ``False``. + :raises ProteinGraphConfigurationError: If the graph does not contain ss features on the nodes (``d['ss'] not in d.keys() for _, d in g.nodes(data=True)``). + :return: The subgraph or node list if ``return_node_list=True``. :rtype: Union[nx.Graph, List[str]] """ @@ -433,20 +436,20 @@ def extract_surface_subgraph( :param g: The graph to extract the subgraph from. :type g: nx.Graph - :param rsa_threshold: The threshold to use for the RSA. Defaults to 0.2 (20%) + :param rsa_threshold: The threshold to use for the RSA. Defaults to ``0.2`` (20%). :type rsa_threshold: float - :param filter_dataframe: Whether to filter the pdb_df of the graph, defaults to True + :param filter_dataframe: Whether to filter the ``pdb_df`` of the graph, defaults to ``True``. :type filter_dataframe: bool, optional - :param update_coords: Whether to update the coordinates of the graph. Defaults to True. + :param update_coords: Whether to update the coordinates of the graph. Defaults to ``True``. :type update_coords: bool - :param recompute_distmat: Whether to recompute the distance matrix of the graph. Defaults to False. + :param recompute_distmat: Whether to recompute the distance matrix of the graph. Defaults to ``False``. :type recompute_distmat: bool - :param inverse: Whether to inverse the selection, defaults to False + :param inverse: Whether to inverse the selection, defaults to ``False``. :type inverse: bool, optional - :param return_node_list: Whether to return the node list. Defaults to False. + :param return_node_list: Whether to return the node list. Defaults to ``False``. :type return_node_list: bool - :raises ProteinGraphConfigurationError: If the graph does not contain RSA features on the nodes (`d['rsa'] not in d.keys() for _, d in g.nodes(data=True)`). - :return: The subgraph or node list if return_node_list is True. + :raises ProteinGraphConfigurationError: If the graph does not contain RSA features on the nodes (``d['rsa'] not in d.keys() for _, d in g.nodes(data=True)``). + :return: The subgraph or node list if ``return_node_list=True``. :rtype: Union[nx.Graph, List[str]] """ node_list: List[str] = [] @@ -488,23 +491,23 @@ def extract_k_hop_subgraph( :param g: The graph to extract the subgraph from. :type g: nx.Graph - :param central_node: The central node to extract the subgraph from. + :param central_node: The central node to extract the subgraph from. E.g. ``"A:SER:12"``. :type central_node: str :param k: The number of hops to extract. :type k: int :param k_only: Whether to only extract the exact k-hop subgraph (e.g. include 2-hop neighbours in 5-hop graph). Defaults to False. :type k_only: bool - :param filter_dataframe: Whether to filter the pdb_df of the graph, defaults to True + :param filter_dataframe: Whether to filter the ``pdb_df`` of the graph, defaults to ``True``. :type filter_dataframe: bool, optional - :param update_coords: Whether to update the coordinates of the graph. Defaults to True. + :param update_coords: Whether to update the coordinates of the graph. Defaults to ``True``. :type update_coords: bool - :param recompute_distmat: Whether to recompute the distance matrix of the graph. Defaults to False. + :param recompute_distmat: Whether to recompute the distance matrix of the graph. Defaults to ``False``. :type recompute_distmat: bool - :param inverse: Whether to inverse the selection, defaults to False + :param inverse: Whether to inverse the selection, defaults to ``False``. :type inverse: bool, optional - :param return_node_list: Whether to return the node list. Defaults to False. + :param return_node_list: Whether to return the node list. Defaults to ``False``. :type return_node_list: bool - :return: The subgraph or node list if return_node_list is True. + :return: The subgraph or node list if ``return_node_list=True``. :rtype: Union[nx.Graph, List[str]] """ neighbours: Dict[int, Union[List[str], set]] = {0: [central_node]} @@ -535,6 +538,86 @@ def extract_k_hop_subgraph( ) +def extract_interface_subgraph( + g: nx.Graph, + interface_list: Optional[List[str]] = None, + chain_list: Optional[List[str]] = None, + filter_dataframe: bool = True, + update_coords: bool = True, + recompute_distmat: bool = False, + inverse: bool = False, + return_node_list: bool = False, +) -> Union[nx.Graph, List[str]]: + """Extracts a subgraph from a graph of a complexed structure (multiple chains). + + If there is an edge between two nodes that are part of different chains it is included in the selection. + NB - if you want to be precise about the interfacial region, you should compute this on the basis of solvent + accessibility and make the selection with :method:`extract_subgraph_from_node_list`. + + :param g: The graph to extract the subgraph from. + :type g: nx.Graph + :param interface_list: A list of interface names to extract e.g. ``["AB", "CD"]``. Default is ``None``. + :type interface_list: Optional[List[str]] + :param chain_list: A list of chain names to extract e.g. ``["A", "B"]``. Default is ``None``. + :type chain_list: Optional[List[str]] + :param filter_dataframe: Whether to filter the ``pdb_df`` dataframe of the graph. Defaults to ``True``. + :type filter_dataframe: bool + :param update_coords: Whether to update the coordinates of the graph. Defaults to ``True``. + :type update_coords: bool + :param recompute_distmat: Whether to recompute the distance matrix of the graph. Defaults to ``False``. + :type recompute_distmat: bool + :param inverse: Whether to inverse the selection. Defaults to ``False``. + :type inverse: bool + :return: The subgraph or node list if ``return_node_list=True``. + :rtype: Union[nx.Graph, List[str]] + """ + node_list: List[str] = [] + # Iterate over edges + for u, v in g.edges(): + u_chain = g.nodes[u]["chain_id"] + v_chain = g.nodes[v]["chain_id"] + + # If a list of chain selections are given, check if the edge is between chains in the list + # Save nodes if the chains are not the same + if ( + chain_list is not None + and u_chain in chain_list + and v_chain in chain_list + and u_chain != v_chain + ): + node_list.extend((u, v)) + + # If a list of valid interfaces is provided, check the nodes are in the valid interfaces + if interface_list is not None: + case_1 = u_chain + v_chain + case_2 = v_chain + u_chain + if case_1 in interface_list or case_2 in interface_list: + node_list.extend((u, v)) + + # In the absence of selection params + # Save nodes if the chains are not the same + if ( + chain_list is None + and interface_list is None + and u_chain != v_chain + ): + node_list.extend((u, v)) + + node_list = list(set(node_list)) + + log.debug(f"Found {len(node_list)} nodes in the interface subgraph.") + + return extract_subgraph_from_node_list( + g, + node_list, + filter_dataframe=filter_dataframe, + inverse=inverse, + return_node_list=return_node_list, + recompute_distmat=recompute_distmat, + update_coords=update_coords, + ) + + def extract_subgraph( g: nx.Graph, node_list: Optional[List[str]] = None, @@ -562,40 +645,40 @@ def extract_subgraph( :param g: The graph to extract the subgraph from. :type g: nx.Graph - :param node_list: List of nodes to extract specified by their node_id. Defaults to None. + :param node_list: List of nodes to extract specified by their ``node_id``. Defaults to ``None``. :type node_list: List[str], optional - :param sequence_positions: The sequence positions to extract. Defaults to None. + :param sequence_positions: The sequence positions to extract. Defaults to ``None``. :type sequence_positions: List[int], optional - :param chains: The chain(s) to extract. Defaults to None. + :param chains: The chain(s) to extract. Defaults to ``None``. :type chains: List[str], optional - :param residue_types: List of allowable residue types (3 letter residue names). Defaults to None. + :param residue_types: List of allowable residue types (3 letter residue names). Defaults to ``None``. :type residue_types: List[str], optional - :param atom_types: List of allowable atom types. Defaults to None. + :param atom_types: List of allowable atom types. Defaults to ``None``. :type atom_types: List[str], optional - :param centre_point: The centre point to extract the subgraph from. Defaults to None. + :param centre_point: The centre point to extract the subgraph from. Defaults to ``None``. :type centre_point: Union[np.ndarray, Tuple[float, float, float]], optional - :param radius: The radius to extract the subgraph from. Defaults to None. + :param radius: The radius to extract the subgraph from. Defaults to ``None``. :type radius: float, optional - :param ss_elements: List of secondary structure elements to extract. `["H", "B", "E", "G", "I", "T", "S", "-"]` corresponding to Alpha helix - Beta bridge, Strand, Helix-3, Helix-5, Turn, Bend, None. Defaults to None. + :param ss_elements: List of secondary structure elements to extract. ``["H", "B", "E", "G", "I", "T", "S", "-"]`` corresponding to Alpha helix + Beta bridge, Strand, Helix-3, Helix-5, Turn, Bend, None. Defaults to ``None``. :type ss_elements: List[str], optional - :param rsa_threshold: The threshold to use for the RSA. Defaults to None. + :param rsa_threshold: The threshold to use for the RSA. Defaults to ``None``. :type rsa_threshold: float, optional - :param central_node: The central node to extract the subgraph from. Defaults to None. + :param central_node: The central node to extract the subgraph from. Defaults to ``None``. :type central_node: str, optional :param k: The number of hops to extract. :type k: int - :param k_only: Whether to only extract the exact k-hop subgraph (e.g. include 2-hop neighbours in 5-hop graph). Defaults to False. + :param k_only: Whether to only extract the exact k-hop subgraph (e.g. include 2-hop neighbours in 5-hop graph). Defaults to ``False``. :type k_only: bool - :param filter_dataframe: Whether to filter the pdb_df dataframe of the graph. Defaults to True. Defaults to None. + :param filter_dataframe: Whether to filter the ``pdb_df`` dataframe of the graph. Defaults to ``True``. Defaults to ``None``. :type filter_dataframe: bool, optional - :param update_coords: Whether to update the coordinates of the graph. Defaults to True. + :param update_coords: Whether to update the coordinates of the graph. Defaults to ``True``. :type update_coords: bool - :param recompute_distmat: Whether to recompute the distance matrix of the graph. Defaults to False. + :param recompute_distmat: Whether to recompute the distance matrix of the graph. Defaults to ``False``. :type recompute_distmat: bool - :param inverse: Whether to inverse the selection. Defaults to False. + :param inverse: Whether to inverse the selection. Defaults to ``False``. :type inverse: bool, optional - :return: The subgraph or node list if return_node_list is True. + :return: The subgraph or node list if ``return_node_list=True``. :rtype: Union[nx.Graph, List[str]] """ if node_list is None: diff --git a/graphein/protein/utils.py b/graphein/protein/utils.py index 06a3fc71..10a22469 100644 --- a/graphein/protein/utils.py +++ b/graphein/protein/utils.py @@ -15,7 +15,6 @@ from urllib.request import urlopen import networkx as nx -import numpy as np import pandas as pd import wget from Bio.PDB import PDBList @@ -247,7 +246,13 @@ def three_to_one_with_mods(res: str) -> str: return RESI_THREE_TO_1[res] -def save_graph_to_pdb(g: nx.Graph, path: str, gz: bool = False): +def save_graph_to_pdb( + g: nx.Graph, + path: str, + gz: bool = False, + atoms: bool = True, + hetatms: bool = True, +): """Saves processed ``pdb_df`` (``g.graph["pdb_df"]``) dataframe to a PDB file. N.B. PDBs do not contain connectivity information. @@ -262,12 +267,27 @@ def save_graph_to_pdb(g: nx.Graph, path: str, gz: bool = False): :type gz: bool """ ppd = PandasPdb() - ppd.df["ATOM"] = g.graph["pdb_df"] + atom_df = filter_dataframe( + g.graph["pdb_df"], "record_name", ["ATOM"], boolean=True + ) + hetatm_df = filter_dataframe( + g.graph["pdb_df"], "record_name", ["HETATM"], boolean=True + ) + if atoms: + ppd.df["ATOM"] = atom_df + if hetatms: + ppd.df["HETATM"] = hetatm_df ppd.to_pdb(path=path, records=None, gz=gz, append_newline=True) log.info(f"Successfully saved graph to {path}") -def save_pdb_df_to_pdb(df: pd.DataFrame, path: str, gz: bool = False): +def save_pdb_df_to_pdb( + df: pd.DataFrame, + path: str, + gz: bool = False, + atoms: bool = True, + hetatms: bool = True, +): """Saves pdb dataframe to a PDB file. :param g: Dataframe to save as PDB @@ -277,13 +297,24 @@ def save_pdb_df_to_pdb(df: pd.DataFrame, path: str, gz: bool = False): :param gz: Whether to gzip the file. Defaults to ``False``. :type gz: bool """ + atom_df = filter_dataframe(df, "record_name", ["ATOM"], boolean=True) + hetatm_df = filter_dataframe(df, "record_name", ["HETATM"], boolean=True) ppd = PandasPdb() - ppd.df["ATOM"] = df - ppd.to_pdb(path=path, records=None, gz=False, append_newline=True) + if atoms: + ppd.df["ATOM"] = atom_df + if hetatms: + ppd.df["HETATM"] = hetatm_df + ppd.to_pdb(path=path, records=None, gz=gz, append_newline=True) log.info(f"Successfully saved PDB dataframe to {path}") -def save_rgroup_df_to_pdb(g: nx.Graph, path: str, gz: bool = False): +def save_rgroup_df_to_pdb( + g: nx.Graph, + path: str, + gz: bool = False, + atoms: bool = True, + hetatms: bool = True, +): """Saves R-group (``g.graph["rgroup_df"]``) dataframe to a PDB file. N.B. PDBs do not contain connectivity information. @@ -298,13 +329,22 @@ def save_rgroup_df_to_pdb(g: nx.Graph, path: str, gz: bool = False): :type gz: bool """ ppd = PandasPdb() - ppd.df["ATOM"] = g.graph["rgroup_df"] + atom_df = filter_dataframe( + g.graph["rgroup_df"], "record_name", ["ATOM"], boolean=True + ) + hetatm_df = filter_dataframe( + g.graph["rgroup_df"], "record_name", ["HETATM"], boolean=True + ) + if atoms: + ppd.df["ATOM"] = atom_df + if hetatms: + ppd.df["HETATM"] = hetatm_df ppd.to_pdb(path=path, records=None, gz=gz, append_newline=True) log.info(f"Successfully saved rgroup data to {path}") def is_tool(name: str) -> bool: - """Checks whether ``name`` is on PATH and is marked as an executable. + """Checks whether ``name`` is on ``PATH`` and is marked as an executable. Source: https://stackoverflow.com/questions/11210104/check-if-a-program-exists-from-a-python-script diff --git a/graphein/protein/visualisation.py b/graphein/protein/visualisation.py index 57d256c7..bda81baa 100644 --- a/graphein/protein/visualisation.py +++ b/graphein/protein/visualisation.py @@ -14,8 +14,8 @@ import matplotlib.pyplot as plt import networkx as nx import numpy as np -import plotly.express as px import plotly.colors as co +import plotly.express as px import plotly.graph_objects as go import seaborn as sns from mpl_toolkits.mplot3d import Axes3D @@ -94,7 +94,7 @@ def colour_nodes( # Define color range proportional to number of edges adjacent to a single node if colour_by == "degree": # Get max number of edges connected to a single node - edge_max = max([G.degree[i] for i in G.nodes()]) + edge_max = max(G.degree[i] for i in G.nodes()) colors = [colour_map(G.degree[i] / edge_max) for i in G.nodes()] elif colour_by == "seq_position": colors = [colour_map(i / n) for i in range(n)] @@ -104,6 +104,20 @@ def colour_nodes( zip(chains, list(colour_map(1 / len(chains), 1, len(chains)))) ) colors = [chain_colours[d["chain_id"]] for n, d in G.nodes(data=True)] + elif colour_by == "plddt": + levels: List[str] = ["Very High", "Confident", "Low", "Very Low"] + mapping = dict(zip(sorted(levels), count())) + colors = [] + for _, d in G.nodes(data=True): + if d["b_factor"] > 90: + colors.append((27 / 256, 86 / 256, 206 / 256, 1)) + elif d["b_factor"] > 70: + colors.append((126 / 256, 202 / 256, 239 / 256, 1)) + elif d["b_factor"] > 50: + colors.append((250 / 256, 218 / 256, 77 / 256, 1)) + else: + colors.append((239 / 256, 131 / 256, 83 / 256, 1)) + # colors = [colour_map(mapping[c] / len(levels)) for c in colors] else: node_types = set(nx.get_node_attributes(G, colour_by).values()) mapping = dict(zip(sorted(node_types), count())) @@ -118,7 +132,7 @@ def colour_nodes( def colour_edges( G: nx.Graph, colour_map: matplotlib.colors.ListedColormap, - colour_by: str = "kind", + colour_by: Optional[str] = "kind", set_alpha: float = 1.0, return_as_rgba: bool = False, ) -> List[Tuple[float, float, float, float]] or List[str]: @@ -130,7 +144,7 @@ def colour_edges( :param colour_map: Colourmap to use. :type colour_map: matplotlib.colors.ListedColormap :param colour_by: Edge attribute to colour by. Currently only ``"kind"`` is supported. - :type colour_by: str + :type colour_by: Optional[str] :param set_alpha: Sets a given alpha value between 0.0 and 1.0 for all the edge colours. :type set_alpha: float :param return_as_rgba: Returns a list of rgba strings instead of tuples. @@ -139,9 +153,9 @@ def colour_edges( :rtype: List[Tuple[float, float, float, float]] or List[str] """ if colour_by == "kind": - edge_types = set( + edge_types = { frozenset(a) for a in nx.get_edge_attributes(G, "kind").values() - ) + } mapping = dict(zip(sorted(edge_types), count())) colors = [ colour_map( @@ -150,10 +164,15 @@ def colour_edges( ) for i in G.edges() ] + elif colour_by is None: + colors = [(0.0, 0.0, 0.0, 1.0) for _ in G.edges()] else: - raise NotImplementedError( - "Other edge colouring methods not implemented." - ) + edge_types = set(nx.get_edge_attributes(G, colour_by).values()) + mapping = dict(zip(sorted(edge_types), count())) + colors = [ + colour_map(mapping[d[colour_by]] / len(edge_types)) + for _, _, d in G.edges(data=True) + ] assert ( 0.0 <= set_alpha <= 1.0 @@ -178,7 +197,7 @@ def plotly_protein_structure_graph( node_colour_map=plt.cm.plasma, edge_color_map=plt.cm.plasma, colour_nodes_by: str = "degree", - colour_edges_by: str = "kind", + colour_edges_by: Optional[str] = "kind", ) -> go.Figure: """ Plots protein structure graph using plotly. @@ -202,9 +221,9 @@ def plotly_protein_structure_graph( :param edge_color_map: colour map to use for edges. Defaults to ``plt.cm.plasma``. :type edge_color_map: plt.cm :param colour_nodes_by: Specifies how to colour nodes. ``"degree"``, ``"seq_position"`` or a node feature. - :type colour_edges_by: str - :param colour_edges_by: Specifies how to colour edges. Currently only ``"kind"`` is supported. :type colour_nodes_by: str + :param colour_edges_by: Specifies how to colour edges. Currently only ``"kind"`` or ``None`` are supported. + :type colour_edges_by: Optional[str] :returns: Plotly Graph Objects plot :rtype: go.Figure """ @@ -718,8 +737,7 @@ def asteroid_plot( """ assert node_id in g.nodes(), f"Node {node_id} not in graph" - nodes: Dict[int, List[str]] = {} - nodes[0] = [node_id] + nodes: Dict[int, List[str]] = {0: [node_id]} node_list: List[str] = [node_id] # Iterate over the number of hops and extract nodes in each shell for i in range(1, k): @@ -949,55 +967,3 @@ def plot_chord_diagram( show=show, **kwargs, ) - - -if __name__ == "__main__": - # TODO: Move the block here into tests. - from graphein.protein.config import ProteinGraphConfig - from graphein.protein.edges.atomic import ( - add_atomic_edges, - add_bond_order, - add_ring_status, - ) - from graphein.protein.features.nodes.amino_acid import ( - expasy_protein_scale, - meiler_embedding, - ) - from graphein.protein.graphs import construct_graph - - # Test Point cloud plotting - # v, f, a = create_mesh(pdb_code="3eiy") - # m = convert_verts_and_face_to_mesh(v, f) - # plot_pointcloud(m, "Test") - # TEST PROTEIN STRUCTURE GRAPH PLOTTING - configs = { - "granularity": "atom", - "keep_hets": False, - "deprotonate": True, - "insertions": False, - "verbose": False, - } - - config = ProteinGraphConfig(**configs) - config.edge_construction_functions = [ - add_atomic_edges, - add_ring_status, - add_bond_order, - ] - - config.node_metadata_functions = [meiler_embedding, expasy_protein_scale] - - g = construct_graph( - config=config, pdb_path="../examples/pdbs/3eiy.pdb", pdb_code="3eiy" - ) - - p = plotly_protein_structure_graph( - g, - 30, - (1000, 2000), - colour_nodes_by="element_symbol", - colour_edges_by="kind", - label_node_ids=False, - ) - - p.show() diff --git a/graphein/rna/__init__.py b/graphein/rna/__init__.py index e69de29b..f9d9faf3 100644 --- a/graphein/rna/__init__.py +++ b/graphein/rna/__init__.py @@ -0,0 +1,6 @@ +from .config import * +from .edges import * +from .features import * +from .graphs import * +from .subgraphs import * +from .visualisation import * diff --git a/graphein/rna/config.py b/graphein/rna/config.py new file mode 100644 index 00000000..0c296045 --- /dev/null +++ b/graphein/rna/config.py @@ -0,0 +1,89 @@ +"""Base Config object for use with RNA Graph Construction.""" +# Graphein +# Author: Arian Jamasb +# License: MIT +# Project Website: https://github.com/a-r-j/graphein +# Code Repository: https://github.com/a-r-j/graphein +from __future__ import annotations + +from functools import partial +from pathlib import Path +from typing import Any, Callable, List, Optional, Union + +from deepdiff import DeepDiff +from pydantic import BaseModel + +from graphein.rna.edges import add_atomic_edges +from graphein.utils.config import PartialMatchOperator, PathMatchOperator + + +class BpRNAConfig(BaseModel): + """Config for managing BpRNA + :param path: Path to bpRNA + :type path: str + """ + + path: str = "./bpRNA" + + +class RNAGraphConfig(BaseModel): + """ + Config Object for RNA Structure Graph Construction. + + :param granularity: Specifies the node types of the graph, defaults to + ``"rna"`` for atoms as nodes. Other options are ``"rna-centroid"`` or + any RNA atom name. + :param verbose: Specifies verbosity of graph creation process. + :type verbose: bool + :param rna_df_processing_functions: List of functions that take a + ``pd.DataFrame`` and return a ``pd.DataFrame``. This allows users to + define their own series of processing functions for the RNA structure + DataFrame and override the default sequencing of processing steps + provided by Graphein. We refer users to our low-level API tutorial for + more details. + :type rna_df_processing_functions: Optional[List[Callable]] + :param edge_construction_functions: List of functions that take an + ``nx.Graph`` and return an ``nx.Graph`` with desired edges added. + Prepared edge constructions can be found in :ref:`graphein.rna.edges` + :type edge_construction_functions: List[Callable] + :param node_metadata_functions: List of functions that take an ``nx.Graph`` + :type node_metadata_functions: List[Callable], optional + :param edge_metadata_functions: List of functions that take an + :type edge_metadata_functions: List[Callable], optional + :param graph_metadata_functions: List of functions that take an ``nx.Graph`` + and return an ``nx.Graph`` with added graph-level features and metadata. + :type graph_metadata_functions: List[Callable], optional + """ + + granularity: str = "rna_atom" + verbose: bool = False + insertions: bool = False + keep_hets: List[str] = [] + + # Graph construction functions + edge_construction_functions: List[Union[Callable, str]] = [ + add_atomic_edges + ] + rna_df_processing_functions: Optional[List[Callable]] = None + node_metadata_functions: Optional[List[Union[Callable, str]]] = None + edge_metadata_functions: Optional[List[Union[Callable, str]]] = None + graph_metadata_functions: Optional[List[Callable]] = None + + def __eq__(self, other: Any) -> bool: + """ + Overwrites the BaseModel __eq__ function in order to check more + specific cases (like partial functions). + """ + if isinstance(other, RNAGraphConfig): + return ( + DeepDiff( + self, + other, + custom_operators=[ + PartialMatchOperator(types=[partial]), + PathMatchOperator(types=[Path]), + ], + ) + == {} + ) + return self.dict() == other diff --git a/graphein/rna/constants.py b/graphein/rna/constants.py index 6d2d61be..b95b490e 100644 --- a/graphein/rna/constants.py +++ b/graphein/rna/constants.py @@ -84,3 +84,213 @@ "pseudoknot", ] """List of valid secondary structure bond types.""" + +RNA_ATOMS: List[str] = [ + "C1'", + "C2", + "C2'", + "C3'", + "C4", + "C4'", + "C5", + "C5'", + "C6", + "C8", + "N1", + "N2", + "N3", + "N4", + "N6", + "N7", + "N9", + "O2", + "O2'", + "O3'", + "O4", + "O4'", + "O5'", + "O6", + "OP1", + "OP2", + "P", +] +"""List of valid RNA atoms found in PDB structures.""" + +PHOSPHORIC_ACID_ATOMS: List[str] = ["P", "OP1", "OP2"] + +RIBOSE_ATOMS: List[str] = [ + "C1'", + "O1'", + "C2'", + "O2'", + "C3'", + "O3'", + "C4'", + "O4'", + "C5'", + "O5'", +] + +RNA_BACKBONE_ATOMS = RIBOSE_ATOMS + PHOSPHORIC_ACID_ATOMS + +RNA_ATOMIC_RADII: Dict[str, float] = { + "Csb": 0.77, + "Cres": 0.72, + "Cdb": 0.67, + "Nsb": 0.70, + "Ndb": 0.62, + "H": 0.37, + "Osb": 0.67, + "Odb": 0.60, + "P": 0.92, +} +"""List of atomic radii (in angstroms) from Heyrovska 2008.""" + +PHOSPHORIC_ACID_BOND_STATE: Dict[str, str] = { + "P": "P", + "OP1": "Osb", # TODO check this? Maybe incorrect + "OP2": "Odb", # TODO check this? Maybe incorrect +} + +RIBOSE_BOND_STATE: Dict[str, str] = { + "C1'": "Cres", + "O1'": "Osb", + "C2'": "Cres", + "O2'": "Osb", + "C3'": "Cres", + "O3'": "Osb", + "C4'": "Cres", + "O4'": "Osb", + "C5'": "Cres", + "O5'": "Osb", + "H": "H", +} + +RNA_BACKBONE_BOND_STATE: Dict[str, str] = { + **RIBOSE_BOND_STATE, + **PHOSPHORIC_ACID_BOND_STATE, +} + +DEOXYRIBOSE_BOND_STATE: Dict[str, str] = { + "C1'": "Cres", + "O1'": "Osb", + "C2'": "Cres", + "O2'": "Osb", + "C3'": "Cres", + "O3'": "Osb", + "C4'": "Cres", + "O4'": "Osb", + "C5'": "Cres", + "O5'": "Osb", + "H": "H", +} + +A_ATOMS: List[str] = [ + "N1", + "C2", + "N3", + "C4", + "C5", + "C6", + "N6", + "N7", + "C8", + "N9", +] + +C_ATOMS: List[str] = [ + "N1", + "C2", + "O2", + "N3", + "C4", + "N4", + "C5", + "C6", +] + +G_ATOMS: List[str] = [ + "N1", + "C2", + "N2", + "N3", + "C4", + "C5", + "C6", + "O6", + "N7", + "C8", + "N9", +] + +T_ATOMS: List[str] = [] + +RNA_ATOM_BOND_STATE: Dict[str, Dict[str, str]] = { + "A": { + "N1": "Ndb", + "C2": "Cres", + "N3": "Ndb", + "C4": "Cres", + "C5": "Cdb", + "C6": "Cres", + "N6": "Nsb", + "N7": "Ndb", + "C8": "Cdb", + "N9": "Nsb", + "H": "H", + **RNA_BACKBONE_BOND_STATE, + }, + "C": { + "N1": "Nsb", + "C2": "Cdb", + "O2": "Odb", + "N3": "Ndb", + "C4": "Cdb", + "N4": "Nsb", + "C5": "Cres", + "C6": "Cdb", + "H": "H", + **RNA_BACKBONE_BOND_STATE, + }, + "G": { + "N1": "Nsb", + "C2": "Cdb", + "N2": "Nsb", + "N3": "Ndb", + "C4": "Cdb", + "C5": "Cres", + "C6": "Cdb", + "O6": "Odb", + "N7": "Ndb", + "C8": "Cdb", + "N9": "Nsb", + "H": "H", + **RNA_BACKBONE_BOND_STATE, + }, + "T": { + "N1": "Nsb", + "C2": "Cdb", + "O2": "Odb", + "N3": "Nsb", + "C4": "Cdb", + "O4": "Odb", + "C5": "Cres", + "C": "Csb", # TODO check this? Maybe incorrect + "C6": "Cdb", + "H": "H", + **RNA_BACKBONE_BOND_STATE, + }, + "U": { + "N1": "Nsb", + "C2": "Cdb", + "O2": "Odb", + "N3": "Nsb", + "C4": "Cdb", + "O4": "Odb", + "C5": "Cres", + "C6": "Cdb", + "H": "H", + **RNA_BACKBONE_BOND_STATE, + }, +} +"""List of atoms mapped to bondstates from Heyrovska 2008.""" diff --git a/graphein/rna/edges/__init__.py b/graphein/rna/edges/__init__.py new file mode 100644 index 00000000..8c5d561d --- /dev/null +++ b/graphein/rna/edges/__init__.py @@ -0,0 +1,3 @@ +from .atomic import * +from .base_pairing import * +from .distance import * diff --git a/graphein/rna/edges/atomic.py b/graphein/rna/edges/atomic.py new file mode 100644 index 00000000..8a8a2d59 --- /dev/null +++ b/graphein/rna/edges/atomic.py @@ -0,0 +1,121 @@ +"""Functions for computing atomic structure of proteins.""" +import logging + +# %% +# Graphein +# Author: Arian Jamasb +# License: MIT +# Project Website: https://github.com/a-r-j/graphein +# Code Repository: https://github.com/a-r-j/graphein +from typing import Any, Dict + +import networkx as nx +import numpy as np +from scipy.spatial import distance_matrix + +import graphein.protein.edges.atomic as protein +from graphein.rna.features.atom import add_atomic_radii + +log = logging.getLogger(__name__) + +# TODO dealing with metals +# TODO There are other check and balances that can be implemented from here: https://www.daylight.com/meetings/mug01/Sayle/m4xbondage.html + + +def add_atomic_edges(G: nx.Graph, tolerance: float = 0.56) -> nx.Graph: + """ + Computes covalent edges based on atomic distances. Covalent radii are assigned to each atom based on its bond state. + The distance matrix is then thresholded to entries less than this distance plus some tolerance to create an adjacency matrix. + This adjacency matrix is then parsed into an edge list and covalent edges added + + Bond states and covalent radii are retrieved from: + + Structures of the Molecular Components in DNA and RNA with Bond Lengths Interpreted as Sums of Atomic Covalent Radii + Raji Heyrovska + + :param G: Atomic graph (nodes correspond to atoms) to populate with atomic bonds as edges + :type G: nx.Graph + :param tolerance: Tolerance for atomic distance. Default is ``0.56`` Angstroms. Commonly used values are: ``0.4, 0.45, 0.56`` + :type tolerance: float + :return: Atomic graph with edges between bonded atoms added + :rtype: nx.Graph + """ + dist_mat = distance_matrix(G.graph["coords"], G.graph["coords"]) + + # Add atomic radii if not present + for n, d in G.nodes(data=True): + if "atomic_radius" not in d.keys(): + add_atomic_radii(n, d) + + radii = np.array(list(nx.get_node_attributes(G, "atomic_radius").values())) + + # Create a covalent 'distance' matrix by adding the radius arrays with its transpose + covalent_radius_distance_matrix = np.add( + radii.reshape(-1, 1), + radii.reshape(1, -1), + ) + # Add the tolerance + covalent_radius_distance_matrix = ( + covalent_radius_distance_matrix + tolerance + ) + + # Threshold Distance Matrix to entries where the euclidean distance is less than the covalent radius plus tolerance and larger than 0.4 + dist_mat[dist_mat < 0.4] = np.nan + dist_mat[dist_mat > covalent_radius_distance_matrix] = np.nan + # Store atomic adjacency matrix in graph + G.graph["atomic_adj_mat"] = np.nan_to_num(dist_mat) + + # Get node IDs from non NaN entries in the thresholded distance matrix and add the edge to the graph + inds = zip(*np.where(~np.isnan(dist_mat))) + for i in inds: + length = dist_mat[i[0]][i[1]] + node_1 = G.graph["pdb_df"]["node_id"][i[0]] + node_2 = G.graph["pdb_df"]["node_id"][i[1]] + chain_1 = G.graph["pdb_df"]["chain_id"][i[0]] + chain_2 = G.graph["pdb_df"]["chain_id"][i[1]] + + # Check nodes are in graph + if not (G.has_node(node_1) and G.has_node(node_2)): + continue + + # Check atoms are in the same chain + if not (chain_1 and chain_2): + continue + + if G.has_edge(node_1, node_2): + G.edges[node_1, node_2]["kind"].add("covalent") + G.edges[node_1, node_2]["bond_length"] = length + else: + G.add_edge(node_1, node_2, kind={"covalent"}, bond_length=length) + + # TODO checking degree against MAX_NEIGHBOURS + + return G + + +def add_ring_status(G: nx.Graph) -> nx.Graph: + """ + Identifies rings in the atomic RNA graph. Assigns the edge attribute ``"RING"`` to edges in the ring. We do not distinguish + between aromatic and non-aromatic rings. Functions by identifying all cycles in the graph. + + :param G: Atom-level RNA structure graph to add ring edge types to + :type G: nx.Graph + :return: Atom-level RNA structure graph with added ``"RING"`` edge attribute + :rtype: nx.Graph + """ + return protein.add_ring_status(G) + + +def add_bond_order(G: nx.Graph) -> nx.Graph: + """ + Assign bond orders to the covalent bond edges between atoms on the basis of bond length. Values are taken from: + + Automatic Assignment of Chemical Connectivity to Organic Molecules in the Cambridge Structural Database. + Jon C. Baber and Edward E. Hodgkin* + + :param G: Atomic-level RNA graph with covalent edges. + :type G: nx.Graph + :return: Atomic-level RNA graph with covalent edges annotated with putative bond order. + :rtype: nx.Graph + """ + return protein.add_bond_order(G) diff --git a/graphein/rna/edges.py b/graphein/rna/edges/base_pairing.py similarity index 97% rename from graphein/rna/edges.py rename to graphein/rna/edges/base_pairing.py index af5d7602..c4e0290e 100644 --- a/graphein/rna/edges.py +++ b/graphein/rna/edges/base_pairing.py @@ -20,6 +20,14 @@ log = logging.getLogger(__name__) +BASEPAIRING_EDGE_FUNCS = [ + "add_phosphodiester_bonds", + "add_base_pairing_interactions", + "add_pseudoknots", + "add_base_pairing_interactions", +] + + def check_base_pairing_type(base_1: str, base_2: str) -> str: """ Checks type and validity of base pairing interactions. diff --git a/graphein/rna/edges/distance.py b/graphein/rna/edges/distance.py new file mode 100644 index 00000000..2804f524 --- /dev/null +++ b/graphein/rna/edges/distance.py @@ -0,0 +1 @@ +from graphein.protein.edges import add_distance_threshold, add_k_nn_edges diff --git a/graphein/rna/features/__init__.py b/graphein/rna/features/__init__.py new file mode 100644 index 00000000..e69de29b diff --git a/graphein/rna/features/atom.py b/graphein/rna/features/atom.py new file mode 100644 index 00000000..a26e8a70 --- /dev/null +++ b/graphein/rna/features/atom.py @@ -0,0 +1,37 @@ +"""Functions for featurising RNA Structure Graphs.""" +# %% +# Graphein +# Author: Arian Jamasb +# License: MIT +# Project Website: https://github.com/a-r-j/graphein +# Code Repository: https://github.com/a-r-j/graphein + +from typing import Any, Dict + +from graphein.rna.constants import RNA_ATOM_BOND_STATE, RNA_ATOMIC_RADII + + +def add_atomic_radii(n: str, d: Dict[str, Any]) -> float: + """Add atomic radii to nodes based on values provided in: + + Structures of the Molecular Components in DNA and RNA with Bond + Lengths Interpreted as Sums of Atomic Covalent Radii + Raji Heyrovska + + Atoms in the RNA structure are mapped to their bond states (:const:`~graphein.rna.constants.RNA_ATOM_BOND_STATE`), + which are in turn mapped to the corresponding atomic radii (:const:`~graphein.rna.constants.RNA_ATOMIC_RADII`). + + :param n: The node to add the atomic radius to. + Unused, the argument is provided to retain a consistent function signature. + :type n: str + :param d: The node data. + :type d: Dict[str, Any] + :return: The atomic radius of the node. + :rtype: float + """ + + base = d["residue_name"] + atom = d["atom_type"] + radius = RNA_ATOMIC_RADII[RNA_ATOM_BOND_STATE[base][atom]] + d["atomic_radius"] = radius + return radius diff --git a/graphein/rna/graphs.py b/graphein/rna/graphs.py index de02591a..35d6b35d 100644 --- a/graphein/rna/graphs.py +++ b/graphein/rna/graphs.py @@ -7,15 +7,20 @@ # Code Repository: https://github.com/a-r-j/graphein # This submodule is heavily inspired by: https://github.com/emalgorithm/rna-design/blob/aec77a18abe4850958d6736ec185a6f8cbfdf20c/src/util.py#L9 import logging -from typing import Callable, Dict, List, Optional +from typing import Callable, List, Optional import networkx as nx +import pandas as pd +import graphein.protein.graphs as gp +from graphein.rna.config import BpRNAConfig, RNAGraphConfig from graphein.rna.constants import ( RNA_BASE_COLORS, RNA_BASES, SUPPORTED_DOTBRACKET_NOTATION, ) +from graphein.rna.nussinov import nussinov +from graphein.rna.utils import read_dbn_file from graphein.utils.utils import ( annotate_edge_metadata, annotate_graph_metadata, @@ -54,7 +59,7 @@ def validate_lengths(db: str, seq: str) -> None: :type db: str :param seq: RNA nucleotide sequence to check. :type seq: str - :raises ValueError: Raises ValueError if lengths of dotbracket and sequence do not match. + :raises ValueError: Raises ``ValueError`` if lengths of dotbracket and sequence do not match. """ if len(db) != len(seq): raise ValueError( @@ -81,13 +86,157 @@ def validate_dotbracket(db: str): ) -def construct_rna_graph( +def construct_rna_graph_3d( + config: Optional[RNAGraphConfig] = None, + name: Optional[str] = None, + pdb_path: Optional[str] = None, + pdb_code: Optional[str] = None, + chain_selection: str = "all", + model_index: int = 1, + rna_df_processing_funcs: Optional[List[Callable]] = None, + edge_construction_funcs: Optional[List[Callable]] = None, + edge_annotation_funcs: Optional[List[Callable]] = None, + node_annotation_funcs: Optional[List[Callable]] = None, + graph_annotation_funcs: Optional[List[Callable]] = None, +) -> nx.Graph: + """ + Constructs RNA structure graph from a ``pdb_code`` or ``pdb_path``. + + Users can provide a :class:`~graphein.rna.config.RNAGraphConfig` + object to specify construction parameters. + + However, config parameters can be overridden by passing arguments directly to the function. + + :param config: :class:`~graphein.rna.config.RNAGraphConfig` object. If None, defaults to config in ``graphein.rna.config``. + :type config: graphein.protein.config.RNAGraphConfig, optional + :param pdb_path: Path to ``pdb_file`` to build graph from. Default is ``None``. + :type pdb_path: str, optional + :param pdb_code: 4-character PDB accession pdb_code to build graph from. Default is ``None``. + :type pdb_code: str, optional + :param chain_selection: String of nucleotide chains to include in graph. E.g ``"ABDF"`` or ``"all"``. Default is ``"all"``. + :type chain_selection: str + :param model_index: Index of model to use in the case of structural ensembles. Default is ``1``. + :type model_index: int + :param df_processing_funcs: List of dataframe processing functions. Default is ``None``. + :type df_processing_funcs: List[Callable], optional + :param edge_construction_funcs: List of edge construction functions. Default is ``None``. + :type edge_construction_funcs: List[Callable], optional + :param edge_annotation_funcs: List of edge annotation functions. Default is ``None``. + :type edge_annotation_funcs: List[Callable], optional + :param node_annotation_funcs: List of node annotation functions. Default is ``None``. + :type node_annotation_funcs: List[Callable], optional + :param graph_annotation_funcs: List of graph annotation function. Default is ``None``. + :type graph_annotation_funcs: List[Callable] + :return: RNA Structure Graph + :type: nx.Graph + """ + + # If no config is provided, use default + if config is None: + config = RNAGraphConfig() + + # Get name from pdb_file is no pdb_code is provided + if pdb_path and (pdb_code is None): + pdb_code = gp.get_protein_name_from_filename(pdb_path) + + # If config params are provided, overwrite them + config.rna_df_processing_functions = ( + rna_df_processing_funcs + if config.rna_df_processing_functions is None + else config.rna_df_processing_functions + ) + config.edge_construction_functions = ( + edge_construction_funcs + if config.edge_construction_functions is None + else config.edge_construction_functions + ) + config.node_metadata_functions = ( + node_annotation_funcs + if config.node_metadata_functions is None + else config.node_metadata_functions + ) + config.graph_metadata_functions = ( + graph_annotation_funcs + if config.graph_metadata_functions is None + else config.graph_metadata_functions + ) + config.edge_metadata_functions = ( + edge_annotation_funcs + if config.edge_metadata_functions is None + else config.edge_metadata_functions + ) + + raw_df = gp.read_pdb_to_dataframe( + pdb_path, + pdb_code, + model_index=model_index, + ) + + # raw_df.df["ATOM"] = gp.label_node_id( + # raw_df.df["ATOM"], granularity=config.granularity + # ) + # raw_df.df["HETATM"] = gp.label_node_id( + # raw_df.df["HETATM"], granularity=config.granularity + # ) + # raw_df = gp.sort_dataframe( + # pd.concat([raw_df.df["ATOM"], raw_df.df["HETATM"]]) + # ) + raw_df = gp.sort_dataframe(raw_df) + protein_df = gp.process_dataframe( + raw_df, + chain_selection=chain_selection, + granularity=config.granularity, + insertions=config.insertions, + keep_hets=config.keep_hets, + ) + + # Initialise graph with metadata + g = gp.initialise_graph_with_metadata( + protein_df=protein_df, + raw_pdb_df=raw_df, + name=name, + pdb_code=pdb_code, + pdb_path=pdb_path, + granularity=config.granularity, + ) + # Add nodes to graph + g = gp.add_nodes_to_graph(g) + + # Add config to graph + g.graph["config"] = config + + # Annotate additional node metadata + if config.node_metadata_functions is not None: + g = annotate_node_metadata(g, config.node_metadata_functions) + + # Compute graph edges + g = compute_edges( + g, + funcs=config.edge_construction_functions, + ) + + # Annotate additional graph metadata + if config.graph_metadata_functions is not None: + g = annotate_graph_metadata(g, config.graph_metadata_functions) + + # Annotate additional edge metadata + if config.edge_metadata_functions is not None: + g = annotate_edge_metadata(g, config.edge_metadata_functions) + + return g + + +def construct_rna_graph_2d( dotbracket: Optional[str], sequence: Optional[str], - edge_construction_funcs: List[Callable], + name: Optional[str] = None, + bprna_id: Optional[str] = None, + edge_construction_funcs: Optional[List[Callable]] = None, edge_annotation_funcs: Optional[List[Callable]] = None, node_annotation_funcs: Optional[List[Callable]] = None, graph_annotation_funcs: Optional[List[Callable]] = None, + use_nussinov: bool = False, + config: Optional[RNAGraphConfig] = None, ) -> nx.Graph: """ Constructs an RNA secondary structure graph from dotbracket notation. @@ -96,6 +245,8 @@ def construct_rna_graph( :type dotbracket: str, optional :param sequence: Corresponding sequence RNA bases :type sequence: str, optional + :param bprna_id: bp RNA ID of the RNA secondary structure from which to construct the graph. Defaults to ``None``. + :type bprna_id: str, optional :param edge_construction_funcs: List of edge construction functions. Defaults to ``None``. :type edge_construction_funcs: List[Callable], optional :param edge_annotation_funcs: List of edge metadata annotation functions. Defaults to ``None``. @@ -104,10 +255,17 @@ def construct_rna_graph( :type node_annotation_funcs: List[Callable], optional :param graph_annotation_funcs: List of graph metadata annotation functions. Defaults to ``None``. :type graph_annotation_funcs: List[Callable], optional + :param config: BpRNA Configuration object. Defaults to ``None``. Unused unless using a bpRNA to compute a graph. + :type config: BpRNAConfig, optional :return: nx.Graph of RNA secondary structure :rtype: nx.Graph """ - G = nx.Graph() + G = nx.Graph(name=name) + + if bprna_id is not None: + if config is None: + config = BpRNAConfig() + sequence, dotbracket = read_dbn_file(config.path) # Build node IDs first. node_ids = ( @@ -116,6 +274,9 @@ def construct_rna_graph( else list(range(len(dotbracket))) ) + if use_nussinov: + dotbracket = nussinov(sequence) + # Check sequence and dotbracket lengths match if dotbracket and sequence: validate_lengths(dotbracket, sequence) @@ -161,35 +322,48 @@ def construct_rna_graph( return G -if __name__ == "__main__": - import matplotlib.pyplot as plt - - from graphein.rna.edges import ( - add_all_dotbracket_edges, - add_base_pairing_interactions, - add_phosphodiester_bonds, - add_pseudoknots, - ) - - edge_funcs_1 = [ - add_base_pairing_interactions, - add_phosphodiester_bonds, - add_pseudoknots, - ] - edge_funcs_2 = [add_all_dotbracket_edges] - - g = construct_rna_graph( - "......((((((......[[[))))))......]]]....", - sequence=None, - edge_construction_funcs=edge_funcs_1, - ) - - nx.info(g) - - edge_colors = nx.get_edge_attributes(g, "color").values() - node_colors = nx.get_node_attributes(g, "color").values() +def construct_graph( + dotbracket: Optional[str] = None, + sequence: Optional[str] = None, + bprna_id: Optional[str] = None, + use_nussinov: bool = False, + name: Optional[str] = None, + config: Optional[RNAGraphConfig] = None, + pdb_path: Optional[str] = None, + pdb_code: Optional[str] = None, + chain_selection: str = "all", + rna_df_processing_funcs: Optional[List[Callable]] = None, + edge_construction_funcs: Optional[List[Callable]] = None, + edge_annotation_funcs: Optional[List[Callable]] = None, + node_annotation_funcs: Optional[List[Callable]] = None, + graph_annotation_funcs: Optional[List[Callable]] = None, +) -> nx.Graph: - nx.draw( - g, edge_color=edge_colors # , node_color=node_colors, with_labels=True - ) - plt.show() + if pdb_path is not None or pdb_code is not None: + + return construct_rna_graph_3d( + config=config, + name=name, + pdb_path=pdb_path, + pdb_code=pdb_code, + chain_selection=chain_selection, + rna_df_processing_funcs=rna_df_processing_funcs, + edge_construction_funcs=edge_construction_funcs, + edge_annotation_funcs=edge_annotation_funcs, + node_annotation_funcs=node_annotation_funcs, + graph_annotation_funcs=graph_annotation_funcs, + ) + elif ( + dotbracket is not None or sequence is not None or bprna_id is not None + ): + return construct_rna_graph_2d( + dotbracket=dotbracket, + sequence=sequence, + name=name, + bprna_id=bprna_id, + use_nussinov=use_nussinov, + edge_construction_funcs=edge_construction_funcs, + edge_annotation_funcs=edge_annotation_funcs, + node_annotation_funcs=node_annotation_funcs, + graph_annotation_funcs=graph_annotation_funcs, + ) diff --git a/graphein/rna/nussinov.py b/graphein/rna/nussinov.py new file mode 100644 index 00000000..d1b7548f --- /dev/null +++ b/graphein/rna/nussinov.py @@ -0,0 +1,185 @@ +"""Nussinov algorithm for computing RNA secondary structure adopted from +adopted from https://github.com/cgoliver/Nussinov/blob/master/nussinov.py """ +# %% +# Graphein +# Author: Arian Jamasb , Ryan Greenhalgh +# License: MIT +# Project Website: https://github.com/a-r-j/graphein +# Code Repository: https://github.com/a-r-j/graphein + +from typing import Tuple + +import numpy as np + +MIN_LOOP_LENGTH = 10 + + +def pair_check( + base_pair_tuple: Tuple[str, str], +) -> bool: + """Check if there is a base pair interaction between two bases. + + :param base_pair_tuple: Base pair tuple to test. + :type base_pair_tuple: Tuple[str, str] + :return: ``True`` if base pairs interact else ``False``. + :rtype: bool + """ + return base_pair_tuple in [("A", "U"), ("U", "A"), ("C", "G"), ("G", "C")] + + +def optimal_pairing( + i: int, + j: int, + sequence: str, +) -> int: + """Find the optimal pairing between two positions. + + :param i: Position ``i`` in sequence. + :type i: int + :param j: Position ``j`` in sequence. + :type j: int + :param sequence: RNA sequence. + :type sequence: str + :return: + :rtype: int + """ + + # base case: no pairs allowed when i and j are less than 4 bases apart + if i >= j - MIN_LOOP_LENGTH: + return 0 + + # i and j can either be paired or not be paired, if not paired then the optimal score is optimal_pairing(i,j-1) + unpaired = optimal_pairing(i, j - 1, sequence) + + # check if j can be involved in a pairing with a position t + pairing = [ + 1 + + optimal_pairing(i, t - 1, sequence) + + optimal_pairing(t + 1, j - 1, sequence) + for t in range(i, j - MIN_LOOP_LENGTH) + if pair_check((sequence[t], sequence[j])) + ] or [0] + paired = max(pairing) + + return max(unpaired, paired) + + +def traceback( + i: int, + j: int, + structure: str, + DP: np.ndarray, + sequence: str, +) -> None: + """Recursively check pairing and interactions between base pairs. + + :param i: Position ``i`` in sequence. + :type i: int + :param j: Position ``j`` in sequence. + :type j: int + :param structure: Dot-bracket notation for RNA seq. + :type structure: str + :param DP: Numpy matrix to cache + :type DP: np.ndarray + :param sequence: RNA sequence + :type sequence: str + """ + + # in this case we've gone through the whole sequence. Nothing to do. + if j <= i: + return + # if j is unpaired, there will be no change in score when we take it out, so we just recurse to the next index + elif DP[i][j] == DP[i][j - 1]: + traceback(i, j - 1, structure, DP, sequence) + # consider cases where j forms a pair. + else: + # try pairing j with a matching index k to its left. + for k in [ + b + for b in range(i, j - MIN_LOOP_LENGTH) + if pair_check((sequence[b], sequence[j])) + ]: + # if the score at i,j is the result of adding 1 from pairing (j,k) and whatever score + # comes from the substructure to its left (i, k-1) and to its right (k+1, j-1) + if k < 1: + if DP[i][j] == DP[k + 1][j - 1] + 1: + structure.append((k, j)) + traceback(k + 1, j - 1, structure, DP, sequence) + break + elif DP[i][j] == DP[i][k - 1] + DP[k + 1][j - 1] + 1: + # add the pair (j,k) to our list of pairs + structure.append((k, j)) + # move the recursion to the two substructures formed by this pairing + traceback(i, k - 1, structure, DP, sequence) + traceback(k + 1, j - 1, structure, DP, sequence) + break + + +def write_structure( + sequence: str, + structure: str, +) -> str: + """Convert structure to string. + + :param sequence: RNA sequence. + :type sequence: str + :param structure: RNA dot-bracket. + :type structure: str + :return: Dot-bracket notation as a string. + :rtype: str + """ + dot_bracket = ["." for _ in range(len(sequence))] + for s in structure: + dot_bracket[min(s)] = "(" + dot_bracket[max(s)] = ")" + return "".join(dot_bracket) + + +def initialize( + N: int, +) -> np.ndarray: + """Initialize DP matrix. ``NxN`` matrix that stores the scores of the optimal pairings. + + :param N: Length of RNA sequence + :type N: int + :return: DP matrix for Nussinov Algorithm + :rtype: np.ndarray + """ + + DP = np.empty((N, N)) + DP[:] = np.NAN + for k in range(MIN_LOOP_LENGTH): + for i in range(N - k): + j = i + k + DP[i][j] = 0 + return DP + + +def nussinov( + sequence: str, +) -> str: + """Nussinov algorithm for predicting RNA ss in dot-bracket notation. + + :param sequence: RNA sequence. + :type sequence: str + :return: Dot-bracket notation for RNA sequence. + :rtype: str + """ + N = len(sequence) + DP = initialize(N) + structure = [] + + # fill the DP matrix diagonally + for k in range(MIN_LOOP_LENGTH, N): + for i in range(N - k): + j = i + k + DP[i][j] = optimal_pairing(i, j, sequence) + + # copy values to lower triangle to avoid null references + for i in range(N): + for j in range(i): + DP[i][j] = DP[j][i] + + traceback(0, N - 1, structure, DP, sequence) + + return write_structure(sequence, structure) diff --git a/graphein/rna/subgraphs.py b/graphein/rna/subgraphs.py new file mode 100644 index 00000000..8145b064 --- /dev/null +++ b/graphein/rna/subgraphs.py @@ -0,0 +1,478 @@ +"""Provides functions for extracting subgraphs from RNA graphs.""" +# Graphein +# Author: Arian Jamasb +# License: MIT +# Project Website: https://github.com/a-r-j/graphein +# Code Repository: https://github.com/a-r-j/graphein + +import logging +from typing import List, Optional, Tuple, Union + +import networkx as nx +import numpy as np + +import graphein.protein.subgraphs as protein +from graphein.rna.constants import ( + PHOSPHORIC_ACID_ATOMS, + RIBOSE_ATOMS, + RNA_BACKBONE_ATOMS, +) + +log = logging.getLogger(__name__) + + +def extract_subgraph_from_node_list( + g, + node_list: Optional[List[str]], + filter_dataframe: bool = True, + update_coords: bool = True, + recompute_distmat: bool = False, + inverse: bool = False, + return_node_list: bool = False, +) -> Union[nx.Graph, List[str]]: + """Extracts a subgraph from a graph based on a list of nodes. + + :param g: The graph to extract the subgraph from. + :type g: nx.Graph + :param node_list: The list of nodes to extract. + :type node_list: List[str], optional + :param filter_dataframe: Whether to filter the ``pdb_df`` dataframe of the graph. Defaults to ``True``. + :type filter_dataframe: bool + :param update_coords: Whether to update the coordinates of the graph. Defaults to ``True``. + :type update_coords: bool + :param recompute_distmat: Whether to recompute the distance matrix of the graph. Defaults to ``False``. + :type recompute_distmat: bool + :param inverse: Whether to inverse the selection. Defaults to ``False``. + :type inverse: bool + :return: The subgraph or node list if ``return_node_list=True``. + :rtype: Union[nx.Graph, List[str]] + """ + return protein.extract_subgraph_from_node_list( + g, + node_list=node_list, + filter_dataframe=filter_dataframe, + update_coords=update_coords, + recompute_distmat=recompute_distmat, + inverse=inverse, + return_node_list=return_node_list, + ) + + +def extract_subgraph_from_backbone( + g: nx.Graph, + filter_dataframe: bool = True, + update_coords: bool = True, + recompute_distmat: bool = True, + inverse: bool = False, + return_node_list: bool = False, +): + """Extracts a subgraph from an RNA structure retaining only backbone atoms. + + Backbone atoms are defined in :ref:`graphein.rna.constants.RNA_BACKBONE_ATOMS`. + + :param g: RNA Structure Graph to extract subgraph from. + :type g: nx.Graph + :param filter_dataframe: Whether to filter the ``pdb_df`` dataframe of the graph. Defaults to ``True``. + :type filter_dataframe: bool + :param update_coords: Whether to update the coordinates of the graph. Defaults to ``True``. + :type update_coords: bool + :param recompute_distmat: Whether to recompute the distance matrix of the graph. Defaults to ``False``. + :type recompute_distmat: bool + :param inverse: Whether to inverse the selection. Defaults to ``False``. + :type inverse: bool + :return: The subgraph or node list if ``return_node_list=True``. + :rtype: Union[nx.Graph, List[str]] + """ + return protein.extract_subgraph_from_atom_types( + g, + atom_types=RNA_BACKBONE_ATOMS, + filter_dataframe=filter_dataframe, + update_coords=update_coords, + recompute_distmat=recompute_distmat, + inverse=inverse, + return_node_list=return_node_list, + ) + + +def extract_subgraph_from_bases( + g: nx.Graph, + filter_dataframe: bool = True, + update_coords: bool = True, + recompute_distmat: bool = True, + inverse: bool = False, + return_node_list: bool = False, +): + """Extracts a subgraph from an RNA structure retaining only base atoms. + + Backbone atoms are defined in :ref:`graphein.rna.constancts.RNA_BACKBONE_ATOMS`. We exclude these to perform the selection. + + :param g: RNA Structure Graph to extract subgraph from. + :type g: nx.Graph + :param filter_dataframe: Whether to filter the ``pdb_df`` dataframe of the graph. Defaults to ``True``. + :type filter_dataframe: bool + :param update_coords: Whether to update the coordinates of the graph. Defaults to ``True``. + :type update_coords: bool + :param recompute_distmat: Whether to recompute the distance matrix of the graph. Defaults to ``False``. + :type recompute_distmat: bool + :param inverse: Whether to inverse the selection. Defaults to ``False``. + :type inverse: bool + :return: The subgraph or node list if ``return_node_list=True``. + :rtype: Union[nx.Graph, List[str]] + """ + inverse = not inverse + return protein.extract_subgraph_from_atom_types( + g, + atom_types=RNA_BACKBONE_ATOMS, + filter_dataframe=filter_dataframe, + update_coords=update_coords, + recompute_distmat=recompute_distmat, + inverse=inverse, + return_node_list=return_node_list, + ) + + +def extract_subgraph_from_phosphoric_acid( + g: nx.Graph, + filter_dataframe: bool = True, + update_coords: bool = True, + recompute_distmat: bool = True, + inverse: bool = False, + return_node_list: bool = False, +): + """Extracts a subgraph from an RNA structure retaining only base atoms. + + Phosphoric acid atoms are defined in :ref:`graphein.rna.constancts.PHOSPHORIC_ACID_ATOMS`. + + :param g: RNA Structure Graph to extract subgraph from. + :type g: nx.Graph + :param filter_dataframe: Whether to filter the ``pdb_df`` dataframe of the graph. Defaults to ``True``. + :type filter_dataframe: bool + :param update_coords: Whether to update the coordinates of the graph. Defaults to ``True``. + :type update_coords: bool + :param recompute_distmat: Whether to recompute the distance matrix of the graph. Defaults to ``False``. + :type recompute_distmat: bool + :param inverse: Whether to inverse the selection. Defaults to ``False``. + :type inverse: bool + :return: The subgraph or node list if ``return_node_list=True``. + :rtype: Union[nx.Graph, List[str]] + """ + return protein.extract_subgraph_from_atom_types( + g, + atom_types=PHOSPHORIC_ACID_ATOMS, + filter_dataframe=filter_dataframe, + update_coords=update_coords, + recompute_distmat=recompute_distmat, + inverse=inverse, + return_node_list=return_node_list, + ) + + +def extract_subgraph_from_ribose( + g: nx.Graph, + filter_dataframe: bool = True, + update_coords: bool = True, + recompute_distmat: bool = True, + inverse: bool = False, + return_node_list: bool = False, +): + """Extracts a subgraph from an RNA structure retaining only base atoms. + + Ribose atoms are defined in :ref:`graphein.rna.constancts.RIBOSE_ATOMS`. + + :param g: RNA Structure Graph to extract subgraph from. + :type g: nx.Graph + :param filter_dataframe: Whether to filter the ``pdb_df`` dataframe of the graph. Defaults to ``True``. + :type filter_dataframe: bool + :param update_coords: Whether to update the coordinates of the graph. Defaults to ``True``. + :type update_coords: bool + :param recompute_distmat: Whether to recompute the distance matrix of the graph. Defaults to ``False``. + :type recompute_distmat: bool + :param inverse: Whether to inverse the selection. Defaults to ``False``. + :type inverse: bool + :return: The subgraph or node list if ``return_node_list=True``. + :rtype: Union[nx.Graph, List[str]] + """ + return protein.extract_subgraph_from_atom_types( + g, + atom_types=RIBOSE_ATOMS, + filter_dataframe=filter_dataframe, + update_coords=update_coords, + recompute_distmat=recompute_distmat, + inverse=inverse, + return_node_list=return_node_list, + ) + + +def extract_subgraph_from_point( + g: nx.Graph, + centre_point: Union[np.ndarray, Tuple[float, float, float]], + radius: float, + filter_dataframe: bool = True, + update_coords: bool = True, + recompute_distmat: bool = False, + inverse: bool = False, + return_node_list: bool = False, +) -> Union[nx.Graph, List[str]]: + """Extracts a subgraph from a graph based on a centre point and radius. + + :param g: The graph to extract the subgraph from. + :type g: nx.Graph + :param centre_point: The centre point of the subgraph. + :type centre_point: Tuple[float, float, float] + :param radius: The radius of the subgraph. + :type radius: float + :param filter_dataframe: Whether to filter the ``pdb_df`` dataframe of the graph. Defaults to ``True``. + :type filter_dataframe: bool + :param update_coords: Whether to update the coordinates of the graph. Defaults to ``True``. + :type update_coords: bool + :param recompute_distmat: Whether to recompute the distance matrix of the graph. Defaults to ``False``. + :type recompute_distmat: bool + :param inverse: Whether to inverse the selection. Defaults to ``False``. + :type inverse: bool + :return: The subgraph or node list if ``return_node_list=True``. + :rtype: Union[nx.Graph, List[str]] + """ + return protein.extract_subgraph_from_point( + g=g, + centre_point=centre_point, + radius=radius, + filter_dataframe=filter_dataframe, + update_coords=update_coords, + recompute_distmat=recompute_distmat, + inverse=inverse, + return_node_list=return_node_list, + ) + + +def extract_subgraph_from_atom_types( + g: nx.Graph, + atom_types: List[str], + filter_dataframe: bool = True, + update_coords: bool = True, + recompute_distmat: bool = False, + inverse: bool = False, + return_node_list: bool = False, +) -> Union[nx.Graph, List[str]]: + """Extracts a subgraph from an RNA graph based on a list of atom types. + + :param g: The graph to extract the subgraph from. + :type g: nx.Graph + :param atom_types: The list of atom types to extract. + :type atom_types: List[str] + :param filter_dataframe: Whether to filter the ``pdb_df`` dataframe of the graph. Defaults to ``True``. + :type filter_dataframe: bool + :param update_coords: Whether to update the coordinates of the graph. Defaults to ``True``. + :type update_coords: bool + :param recompute_distmat: Whether to recompute the distance matrix of the graph. Defaults to ``False``. + :type recompute_distmat: bool + :param inverse: Whether to inverse the selection. Defaults to ``False``. + :type inverse: bool + :return: The subgraph or node list if ``return_node_list=True``. + :rtype: Union[nx.Graph, List[str]] + """ + return protein.extract_subgraph_from_atom_types( + g, + atom_types=atom_types, + filter_dataframe=filter_dataframe, + inverse=inverse, + return_node_list=return_node_list, + update_coords=update_coords, + recompute_distmat=recompute_distmat, + ) + + +def extract_subgraph_from_residue_types( + g: nx.Graph, + residue_types: List[str], + filter_dataframe: bool = True, + update_coords: bool = True, + recompute_distmat: bool = False, + inverse: bool = False, + return_node_list: bool = False, +) -> Union[nx.Graph, List[str]]: + """Extracts a subgraph from a graph based on a list of allowable (nucleotide) residue types. + + :param g: The graph to extract the subgraph from. + :type g: nx.Graph + :param residue_types: List of allowable residue types (1-letter residue names). E.g. ``["A", "G"]`` + :type residue_types: List[str] + :param filter_dataframe: Whether to filer the ``pdb_df`` of the graph, defaults to ``True`` + :type filter_dataframe: bool, optional + :param update_coords: Whether to update the coordinates of the graph. Defaults to ``True``. + :type update_coords: bool + :param recompute_distmat: Whether to recompute the distance matrix of the graph. Defaults to ``False``. + :type recompute_distmat: bool + :param inverse: Whether to inverse the selection. Defaults to ``False``. + :type inverse: bool + :return: The subgraph or node list if ``return_node_list=True``. + :rtype: Union[nx.Graph, List[str]] + """ + return protein.extract_subgraph_from_residue_types( + g, + residue_types, + filter_dataframe=filter_dataframe, + inverse=inverse, + return_node_list=return_node_list, + update_coords=update_coords, + recompute_distmat=recompute_distmat, + ) + + +def extract_subgraph_from_chains( + g: nx.Graph, + chains: List[str], + filter_dataframe: bool = True, + update_coords: bool = True, + recompute_distmat: bool = False, + inverse: bool = False, + return_node_list: bool = False, +) -> Union[nx.Graph, List[str]]: + """Extracts a subgraph from a graph based on a chain. + + :param g: The graph to extract the subgraph from. + :type g: nx.Graph + :param chains: The chain(s) to extract. E.g. ``["A", "C"]`` + :type chains: List[str] + :param filter_dataframe: Whether to filter the ``pdb_df`` dataframe of the graph. Defaults to ``True``. + :type filter_dataframe: bool + :param update_coords: Whether to update the coordinates of the graph. Defaults to ``True``. + :type update_coords: bool + :param recompute_distmat: Whether to recompute the distance matrix of the graph. Defaults to ``False``. + :type recompute_distmat: bool + :param inverse: Whether to inverse the selection. Defaults to ``False``. + :type inverse: bool + :return: The subgraph or node list if ``return_node_list=True``. + :rtype: Union[nx.Graph, List[str]] + """ + return protein.extract_subgraph_from_chains( + g, + chains, + filter_dataframe=filter_dataframe, + update_coords=update_coords, + recompute_distmat=recompute_distmat, + inverse=inverse, + return_node_list=return_node_list, + ) + + +def extract_subgraph_by_sequence_position( + g: nx.Graph, + sequence_positions: List[int], + filter_dataframe: bool = True, + update_coords: bool = True, + recompute_distmat: bool = False, + inverse: bool = False, + return_node_list: bool = False, +) -> Union[nx.Graph, List[str]]: + """Extracts a subgraph from a graph based on a chain. + + :param g: The graph to extract the subgraph from. + :type g: nx.Graph + :param chain: The sequence positions to extract. E.g. ``[1, 3, 5, 7]`` + :type chain: List[int] + :param filter_dataframe: Whether to filter the ``pdb_df`` dataframe of the graph. Defaults to ``True``. + :type filter_dataframe: bool + :param update_coords: Whether to update the coordinates of the graph. Defaults to ``True``. + :type update_coords: bool + :param recompute_distmat: Whether to recompute the distance matrix of the graph. Defaults to ``False``. + :type recompute_distmat: bool + :param inverse: Whether to inverse the selection. Defaults to ``False``. + :type inverse: bool + :return: The subgraph or node list if ``return_node_list=True``. + :rtype: Union[nx.Graph, List[str]] + """ + return protein.extract_subgraph_by_sequence_position( + g, + sequence_positions=sequence_positions, + filter_dataframe=filter_dataframe, + inverse=inverse, + return_node_list=return_node_list, + recompute_distmat=recompute_distmat, + update_coords=update_coords, + ) + + +def extract_subgraph_by_bond_type( + g: nx.Graph, + bond_types: List[str], + filter_dataframe: bool = True, + update_coords: bool = True, + recompute_distmat: bool = False, + inverse: bool = False, + return_node_list: bool = False, +) -> Union[nx.Graph, List[str]]: + """Extracts a subgraph from a graph based on a list of allowable bond types. + + :param g: The graph to extract the subgraph from. + :type g: nx.Graph + :param bond_types: List of allowable bond types. + :type bond_types: List[str] + :param filter_dataframe: Whether to filter the ``pdb_df`` of the graph, defaults to ``True``. + :type filter_dataframe: bool, optional + :param update_coords: Whether to update the coordinates of the graph. Defaults to ``True``. + :type update_coords: bool + :param recompute_distmat: Whether to recompute the distance matrix of the graph. Defaults to ``False``. + :type recompute_distmat: bool + :param inverse: Whether to inverse the selection, defaults to ``False``. + :type inverse: bool, optional + :param return_node_list: Whether to return the node list, defaults to ``False``. + :type return_node_list: bool, optional + :return: The subgraph or node list if ``return_node_list=True``. + :rtype: Union[nx.Graph, List[str]] + """ + return protein.extract_subgraph_by_bond_type( + g, + bond_types=bond_types, + filter_dataframe=filter_dataframe, + inverse=inverse, + return_node_list=return_node_list, + recompute_distmat=recompute_distmat, + update_coords=update_coords, + ) + + +def extract_k_hop_subgraph( + g: nx.Graph, + central_node: str, + k: int, + k_only: bool = False, + filter_dataframe: bool = True, + update_coords: bool = True, + recompute_distmat: bool = False, + inverse: bool = False, + return_node_list: bool = False, +) -> Union[nx.Graph, List[str]]: + """Extracts a k-hop subgraph. + + :param g: The graph to extract the subgraph from. + :type g: nx.Graph + :param central_node: The central node to extract the subgraph from. + :type central_node: str + :param k: The number of hops to extract. + :type k: int + :param k_only: Whether to only extract the exact k-hop subgraph (e.g. include 2-hop neighbours in 5-hop graph). Defaults to ``False``. + :type k_only: bool + :param filter_dataframe: Whether to filter the ``pdb_df`` of the graph, defaults to ``True``. + :type filter_dataframe: bool, optional + :param update_coords: Whether to update the coordinates of the graph. Defaults to ``True``. + :type update_coords: bool + :param recompute_distmat: Whether to recompute the distance matrix of the graph. Defaults to ``False``. + :type recompute_distmat: bool + :param inverse: Whether to inverse the selection, defaults to ``False``. + :type inverse: bool, optional + :param return_node_list: Whether to return the node list. Defaults to ``False``. + :type return_node_list: bool + :return: The subgraph or node list if ``return_node_list=True``. + :rtype: Union[nx.Graph, List[str]] + """ + return protein.extract_k_hop_subgraph( + g, + central_node=central_node, + k=k, + k_only=k_only, + filter_dataframe=filter_dataframe, + inverse=inverse, + return_node_list=return_node_list, + recompute_distmat=recompute_distmat, + update_coords=update_coords, + ) diff --git a/graphein/rna/utils.py b/graphein/rna/utils.py new file mode 100644 index 00000000..11d9fbce --- /dev/null +++ b/graphein/rna/utils.py @@ -0,0 +1,65 @@ +"""Utility Functions for working with RNA Secondary Structure Graphs.""" +# %% +# Graphein +# Author: Arian Jamasb +# License: MIT +# Project Website: https://github.com/a-r-j/graphein +# Code Repository: https://github.com/a-r-j/graphein +# This submodule is heavily inspired by: https://github.com/emalgorithm/rna-design/blob/aec77a18abe4850958d6736ec185a6f8cbfdf20c/src/util.py#L9 +import logging +import os +import shutil +from typing import Tuple + +import wget + +BP_RNA_1M_DB_URL: str = ( + "http://bprna.cgrb.oregonstate.edu/bpRNA_1m/dbnFiles.zip" +) +BP_RNA_1M_90_DB_URL: str = "http://bprna.cgrb.oregonstate.edu/bpRNA_1m_90.zip" + +log = logging.getLogger(__name__) + + +def download_bp_rna_1m(out_path: str = "/tmp/"): + """Downloads BP RNA Dotbrackets. + + :param out_path: _description_, defaults to "/tmp/" + :type out_path: str, optional + """ + if os.path.isdir(f"{out_path}/bp_rna_1m"): + log.info( + f"Skipping download. bp_rna_1m already downloaded to {out_path}/bp_rna_1m." + ) + else: + log.info(f"Downloading bp_rna_1m to {out_path}/bp_rna_1m...") + fname = f"{out_path}/bp_rna_1m" + wget.download(BP_RNA_1M_DB_URL, out=f"{fname}.zip") + log.info("Unzipping bp_rna_1m...") + shutil.unpack_archive( + f"{fname}.zip", extract_dir=f"{out_path}/bp_rna_1m" + ) + + +def read_dbn_file(path: str) -> Tuple[str, str]: + """ + Read a dotbracket file to sequence and dotbracket strings. + + :param path: Path to the dotbracket file in ``.dbn`` format. + :type path: str + :return: Tuple of sequence and dotbracket strings. + :rtype: Tuple[str, str] + """ + with open(path, "r") as f: + lines = f.readlines() + print(lines) + sequence = lines[-2] + dotbracket = lines[-1] + return sequence, dotbracket + + +if __name__ == "__main__": + # download_bp_rna_1m(".") + seq, db = read_dbn_file("./bp_rna_1m/dbnFiles/bpRNA_CRW_23156.dbn") + print(seq) + print(db) diff --git a/graphein/rna/visualisation.py b/graphein/rna/visualisation.py index 249e2e76..16990de9 100644 --- a/graphein/rna/visualisation.py +++ b/graphein/rna/visualisation.py @@ -13,6 +13,9 @@ import networkx as nx +from graphein.protein.visualisation import ( + plotly_protein_structure_graph as plotly_rna_structure_graph, +) from graphein.rna.graphs import RNA_BASE_COLORS log = logging.getLogger(__name__) diff --git a/notebooks/alphafold_protein_graph_tutorial.ipynb b/notebooks/alphafold_protein_graph_tutorial.ipynb index 7c4ed9a9..5f66a658 100644 --- a/notebooks/alphafold_protein_graph_tutorial.ipynb +++ b/notebooks/alphafold_protein_graph_tutorial.ipynb @@ -9,9 +9,47619 @@ "\n", "In this quick tutorial we show how to construct graphs from the [AlphaFold Protein Structure Database](https://alphafold.ebi.ac.uk/). This is a fantastic resource for the community and we hope to make it more accessible to the Geometric Deep Learning community!\n", "\n", - "We provide a utility `graphein.protein.utils.download_alphafold_structure()` to download PDBs and associated metadata (aligned error scores as an accompanying `JSON` file). After downloading the structure, simply use Graphein to compute the graph as you normally would. You can check out the [`residue_graphs.ipynb`](https://graphein.ai/notebooks/residue_graphs.html). notebook tutorial to go deeper into protein graph construction utilities in Graphein.\n", + "It's plug and play with the top-level [`graphein.protein.construct_graph()`](https://graphein.ai/modules/graphein.protein.html#graphein.protein.graphs.construct_graph) function; however we now require UniProt identifiers.\n", "\n", - "[![Open In Colab](https://colab.research.google.com/assets/colab-badge.svg)](https://colab.research.google.com/github/a-r-j/graphein/blob/master/notebooks/alphafold_protein_graph_tutorial.ipynb)" + "We also provide a utility [`graphein.protein.utils.download_alphafold_structure()`](https://graphein.ai/modules/graphein.protein.html#graphein.protein.utils.download_alphafold_structure) to download PDBs and associated metadata (aligned error scores as an accompanying `JSON` file). There is also an [equivalent function](https://graphein.ai/modules/graphein.protein.html#graphein.protein.utils.download_pdb) for downloading structures from RCSB. After downloading the structure, simply use Graphein to compute the graph as you normally would. You can check out the [`residue_graphs.ipynb`](https://graphein.ai/notebooks/residue_graphs.html). notebook tutorial to go deeper into protein graph construction utilities in Graphein.\n", + "\n", + "[![Open In Colab](https://colab.research.google.com/assets/colab-badge.svg)](https://colab.research.google.com/github/a-r-j/graphein/blob/master/notebooks/alphafold_protein_graph_tutorial.ipynb)\n", + "\n", + "## Quickstart\n", + "\n", + "The structures are accessed via their [UniProt](https://www.uniprot.org/) accession codes.\n", + "\n", + "Here, we'll be looking at [`Q8W3K0`](https://alphafold.ebi.ac.uk/entry/Q8W3K0), a rather beautiful model of a protein with a not-so-catchy name: Probable disease resistance protein At1g58602." + ] + }, + { + "cell_type": "code", + "execution_count": 1, + "id": "5a2ecafa", + "metadata": {}, + "outputs": [], + "source": [ + "# Install graphein if necessary\n", + "#!pip install graphein" + ] + }, + { + "cell_type": "code", + "execution_count": 2, + "id": "42e0e918", + "metadata": {}, + "outputs": [ + { + "data": { + "text/html": [ + "
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"A:PHE:347", + "A:GLU:348", + "A:ILE:349", + "A:ASP:350", + "A:GLU:351", + "A:GLU:352", + "A:MET:353", + "A:GLU:354", + "A:LYS:355", + "A:LEU:356", + "A:GLY:357", + "A:GLU:358", + "A:LYS:359", + "A:MET:360", + "A:ILE:361", + "A:GLU:362", + "A:HIS:363", + "A:CYS:364", + "A:GLY:365", + "A:GLY:366", + "A:LEU:367", + "A:PRO:368", + "A:LEU:369", + "A:ALA:370", + "A:ILE:371", + "A:LYS:372", + "A:VAL:373", + "A:LEU:374", + "A:GLY:375", + "A:GLY:376", + "A:MET:377", + "A:LEU:378", + "A:ALA:379", + "A:GLU:380", + "A:LYS:381", + "A:TYR:382", + "A:THR:383", + "A:SER:384", + "A:HIS:385", + "A:ASP:386", + "A:TRP:387", + "A:ARG:388", + "A:ARG:389", + "A:LEU:390", + "A:SER:391", + "A:GLU:392", + "A:ASN:393", + "A:ILE:394", + "A:GLY:395", + "A:SER:396", + "A:HIS:397", + "A:LEU:398", + "A:VAL:399", + "A:GLY:400", + "A:GLY:401", + "A:ARG:402", + "A:THR:403", + "A:ASN:404", + "A:PHE:405", + "A:ASN:406", + "A:ASP:407", + "A:ASP:408", + "A:ASN:409", + "A:ASN:410", + "A:ASN:411", + "A:SER:412", + "A:CYS:413", + "A:ASN:414", + "A:TYR:415", + "A:VAL:416", + "A:LEU:417", + "A:SER:418", + "A:LEU:419", + "A:SER:420", + "A:PHE:421", + "A:GLU:422", + "A:GLU:423", + "A:LEU:424", + "A:PRO:425", + "A:SER:426", + "A:TYR:427", + "A:LEU:428", + "A:LYS:429", + "A:HIS:430", + "A:CYS:431", + "A:PHE:432", + "A:LEU:433", + "A:TYR:434", + "A:LEU:435", + "A:ALA:436", + "A:HIS:437", + "A:PHE:438", + "A:PRO:439", + "A:GLU:440", + "A:ASP:441", + "A:TYR:442", + "A:GLU:443", + "A:ILE:444", + "A:LYS:445", + "A:VAL:446", + "A:GLU:447", + "A:ASN:448", + "A:LEU:449", + "A:SER:450", + "A:TYR:451", + "A:TYR:452", + "A:TRP:453", + "A:ALA:454", + "A:ALA:455", + "A:GLU:456", + "A:GLU:457", + "A:ILE:458", + "A:PHE:459", + "A:GLN:460", + "A:PRO:461", + "A:ARG:462", + "A:HIS:463", + "A:TYR:464", + "A:ASP:465", + "A:GLY:466", + "A:GLU:467", + "A:ILE:468", + "A:ILE:469", + "A:ARG:470", + "A:ASP:471", + "A:VAL:472", + "A:GLY:473", + "A:ASP:474", + "A:VAL:475", + "A:TYR:476", + "A:ILE:477", + "A:GLU:478", + "A:GLU:479", + "A:LEU:480", + "A:VAL:481", + "A:ARG:482", + "A:ARG:483", + "A:ASN:484", + "A:MET:485", + "A:VAL:486", + "A:ILE:487", + "A:SER:488", + "A:GLU:489", + "A:ARG:490", + "A:ASP:491", + "A:VAL:492", + "A:LYS:493", + "A:THR:494", + "A:SER:495", + "A:ARG:496", + "A:PHE:497", + "A:GLU:498", + "A:THR:499", + "A:CYS:500", + "A:HIS:501", + "A:LEU:502", + "A:HIS:503", + "A:ASP:504", + "A:MET:505", + "A:MET:506", + "A:ARG:507", + "A:GLU:508", + "A:VAL:509", + "A:CYS:510", + "A:LEU:511", + "A:LEU:512", + "A:LYS:513", + "A:ALA:514", + "A:LYS:515", + "A:GLU:516", + "A:GLU:517", + "A:ASN:518", + "A:PHE:519", + "A:LEU:520", + "A:GLN:521", + "A:ILE:522", + "A:THR:523", + "A:SER:524", + "A:ASN:525", + "A:PRO:526", + "A:PRO:527", + "A:SER:528", + "A:THR:529", + "A:ALA:530", + "A:ASN:531", + "A:PHE:532", + "A:GLN:533", + "A:SER:534", + "A:THR:535", + "A:VAL:536", + "A:THR:537", + "A:SER:538", + "A:ARG:539", + "A:ARG:540", + "A:LEU:541", + "A:VAL:542", + "A:TYR:543", + "A:GLN:544", + "A:TYR:545", + "A:PRO:546", + "A:THR:547", + "A:THR:548", + "A:LEU:549", + "A:HIS:550", + "A:VAL:551", + "A:GLU:552", + "A:LYS:553", + "A:ASP:554", + "A:ILE:555", + "A:ASN:556", + "A:ASN:557", + "A:PRO:558", + "A:LYS:559", + "A:LEU:560", + "A:ARG:561", + "A:SER:562", + "A:LEU:563", + "A:VAL:564", + "A:VAL:565", + "A:VAL:566", + "A:THR:567", + "A:LEU:568", + "A:GLY:569", + "A:SER:570", + "A:TRP:571", + "A:ASN:572", + "A:MET:573", + "A:ALA:574", + "A:GLY:575", + "A:SER:576", + "A:SER:577", + "A:PHE:578", + "A:THR:579", + "A:ARG:580", + "A:LEU:581", + "A:GLU:582", + "A:LEU:583", + "A:LEU:584", + "A:ARG:585", + "A:VAL:586", + "A:LEU:587", + "A:ASP:588", + "A:LEU:589", + "A:VAL:590", + "A:GLN:591", + "A:ALA:592", + "A:LYS:593", + "A:LEU:594", + "A:LYS:595", + "A:GLY:596", + "A:GLY:597", + "A:LYS:598", + "A:LEU:599", + "A:ALA:600", + "A:SER:601", + "A:CYS:602", + "A:ILE:603", + "A:GLY:604", + "A:LYS:605", + "A:LEU:606", + "A:ILE:607", + "A:HIS:608", + "A:LEU:609", + "A:ARG:610", + "A:TYR:611", + "A:LEU:612", + "A:SER:613", + "A:LEU:614", + "A:GLU:615", + "A:TYR:616", + "A:ALA:617", + "A:GLU:618", + "A:VAL:619", + "A:THR:620", + "A:HIS:621", + "A:ILE:622", + "A:PRO:623", + "A:TYR:624", + "A:SER:625", + "A:LEU:626", + "A:GLY:627", + "A:ASN:628", + "A:LEU:629", + "A:LYS:630", + "A:LEU:631", + "A:LEU:632", + "A:ILE:633", + "A:TYR:634", + "A:LEU:635", + "A:ASN:636", + "A:LEU:637", + "A:HIS:638", + "A:ILE:639", + "A:SER:640", + "A:LEU:641", + "A:SER:642", + "A:SER:643", + "A:ARG:644", + "A:SER:645", + "A:ASN:646", + "A:PHE:647", + "A:VAL:648", + "A:PRO:649", + "A:ASN:650", + "A:VAL:651", + "A:LEU:652", + "A:MET:653", + "A:GLY:654", + "A:MET:655", + "A:GLN:656", + "A:GLU:657", + "A:LEU:658", + "A:ARG:659", + "A:TYR:660", + "A:LEU:661", + "A:ALA:662", + "A:LEU:663", + "A:PRO:664", + "A:SER:665", + "A:LEU:666", + "A:ILE:667", + "A:GLU:668", + "A:ARG:669", + "A:LYS:670", + "A:THR:671", + "A:LYS:672", + "A:LEU:673", + "A:GLU:674", + "A:LEU:675", + "A:SER:676", + "A:ASN:677", + "A:LEU:678", + "A:VAL:679", + "A:LYS:680", + "A:LEU:681", + "A:GLU:682", + "A:THR:683", + "A:LEU:684", + "A:GLU:685", + "A:ASN:686", + "A:PHE:687", + "A:SER:688", + "A:THR:689", + "A:LYS:690", + "A:ASN:691", + "A:SER:692", + "A:SER:693", + "A:LEU:694", + "A:GLU:695", + "A:ASP:696", + "A:LEU:697", + "A:ARG:698", + "A:GLY:699", + "A:MET:700", + "A:VAL:701", + "A:ARG:702", + "A:LEU:703", + "A:ARG:704", + "A:THR:705", + "A:LEU:706", + "A:THR:707", + "A:ILE:708", + "A:GLU:709", + "A:LEU:710", + "A:ILE:711", + "A:GLU:712", + "A:GLU:713", + "A:THR:714", + "A:SER:715", + "A:LEU:716", + "A:GLU:717", + "A:THR:718", + "A:LEU:719", + "A:ALA:720", + "A:ALA:721", + "A:SER:722", + "A:ILE:723", + "A:GLY:724", + "A:GLY:725", + "A:LEU:726", + "A:LYS:727", + "A:TYR:728", + "A:LEU:729", + "A:GLU:730", + "A:LYS:731", + "A:LEU:732", + "A:GLU:733", + "A:ILE:734", + "A:ASP:735", + "A:ASP:736", + "A:LEU:737", + "A:GLY:738", + "A:SER:739", + "A:LYS:740", + "A:MET:741", + "A:ARG:742", + "A:THR:743", + "A:LYS:744", + "A:GLU:745", + "A:ALA:746", + "A:GLY:747", + "A:ILE:748", + "A:VAL:749", + "A:PHE:750", + "A:ASP:751", + "A:PHE:752", + "A:VAL:753", + "A:HIS:754", + "A:LEU:755", + "A:LYS:756", + "A:ARG:757", + "A:LEU:758", + "A:ARG:759", + "A:LEU:760", + "A:GLU:761", + "A:LEU:762", + "A:TYR:763", + "A:MET:764", + "A:PRO:765", + "A:ARG:766", + "A:LEU:767", + "A:SER:768", + "A:LYS:769", + "A:GLU:770", + "A:GLN:771", + "A:HIS:772", + "A:PHE:773", + "A:PRO:774", + "A:SER:775", + "A:HIS:776", + "A:LEU:777", + "A:THR:778", + "A:THR:779", + "A:LEU:780", + "A:TYR:781", + "A:LEU:782", + "A:GLN:783", + "A:HIS:784", + "A:CYS:785", + "A:ARG:786", + "A:LEU:787", + "A:GLU:788", + "A:GLU:789", + "A:ASP:790", + "A:PRO:791", + "A:MET:792", + "A:PRO:793", + "A:ILE:794", + "A:LEU:795", + "A:GLU:796", + "A:LYS:797", + "A:LEU:798", + "A:LEU:799", + "A:GLN:800", + "A:LEU:801", + "A:LYS:802", + "A:GLU:803", + "A:LEU:804", + "A:GLU:805", + "A:LEU:806", + "A:GLY:807", + "A:HIS:808", + "A:LYS:809", + "A:SER:810", + "A:PHE:811", + "A:SER:812", + "A:GLY:813", + "A:LYS:814", + "A:LYS:815", + "A:MET:816", + "A:VAL:817", + "A:CYS:818", + "A:SER:819", + "A:SER:820", + "A:CYS:821", + "A:GLY:822", + "A:PHE:823", + "A:PRO:824", + "A:GLN:825", + "A:LEU:826", + "A:GLN:827", + "A:LYS:828", + "A:LEU:829", + "A:SER:830", + "A:ILE:831", + "A:SER:832", + "A:GLY:833", + "A:LEU:834", + "A:LYS:835", + "A:GLU:836", + "A:TRP:837", + "A:GLU:838", + "A:ASP:839", + "A:TRP:840", + "A:LYS:841", + "A:VAL:842", + "A:GLU:843", + "A:GLU:844", + "A:SER:845", + "A:SER:846", + "A:MET:847", + "A:PRO:848", + "A:LEU:849", + "A:LEU:850", + "A:LEU:851", + "A:THR:852", + "A:LEU:853", + "A:ASN:854", + "A:ILE:855", + "A:PHE:856", + "A:ASP:857", + "A:CYS:858", + "A:ARG:859", + "A:LYS:860", + "A:LEU:861", + "A:LYS:862", + "A:GLN:863", + "A:LEU:864", + "A:PRO:865", + "A:ASP:866", + "A:GLU:867", + "A:HIS:868", + "A:LEU:869", + "A:PRO:870", + "A:SER:871", + "A:HIS:872", + "A:LEU:873", + "A:THR:874", + "A:ALA:875", + "A:ILE:876", + "A:SER:877", + "A:LEU:878", + "A:LYS:879", + "A:LYS:880", + "A:CYS:881", + "A:GLY:882", + "A:LEU:883", + "A:GLU:884", + "A:ASP:885", + "A:PRO:886", + "A:ILE:887", + "A:PRO:888", + "A:THR:889", + "A:LEU:890", + "A:GLU:891", + "A:ARG:892", + "A:LEU:893", + "A:VAL:894", + "A:HIS:895", + "A:LEU:896", + "A:LYS:897", + "A:GLU:898", + "A:LEU:899", + "A:SER:900", + "A:LEU:901", + "A:SER:902", + "A:GLU:903", + "A:LEU:904", + "A:CYS:905", + "A:GLY:906", + "A:ARG:907", + "A:ILE:908", + "A:MET:909", + "A:VAL:910", + "A:CYS:911", + "A:THR:912", + "A:GLY:913", + "A:GLY:914", + "A:GLY:915", + "A:PHE:916", + "A:PRO:917", + "A:GLN:918", + "A:LEU:919", + "A:HIS:920", + "A:LYS:921", + "A:LEU:922", + "A:ASP:923", + "A:LEU:924", + "A:SER:925", + "A:GLU:926", + "A:LEU:927", + "A:ASP:928", + "A:GLY:929", + "A:LEU:930", + "A:GLU:931", + "A:GLU:932", + "A:TRP:933", + "A:ILE:934", + "A:VAL:935", + "A:GLU:936", + "A:ASP:937", + "A:GLY:938", + "A:SER:939", + "A:MET:940", + 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+ "gridcolor": "white", + "linecolor": "white", + "ticks": "", + "title": { + "standoff": 15 + }, + "zerolinecolor": "white", + "zerolinewidth": 2 + } + } + }, + "width": 620 + } + } + }, + "metadata": {}, + "output_type": "display_data" + } + ], + "source": [ + "import graphein.protein as gp\n", + "\n", + "g = gp.construct_graph(uniprot_id=\"Q8W3K0\")\n", + "gp.plotly_protein_structure_graph(g, colour_nodes_by=\"plddt\") # Colouring by plDDT shows the assigned confidences!" ] }, { @@ -20,46 +47630,22 @@ "metadata": {}, "source": [ "## Downloading Structures\n", - "First, we need to download the strutures from AlphaFoldDB. One can download either the structure alone or the aligned scores.\n", - "\n", - "The structures are accessed via their [UniProt](https://www.uniprot.org/) accession codes.\n", - "\n", - "Here, we'll be looking at [`Q8W3K0`](https://alphafold.ebi.ac.uk/entry/Q8W3K0), a rather beautiful model of a protein with a not-so-catchy name: Probable disease resistance protein At1g58602." + "First, we need to download the strutures from AlphaFoldDB. One can download either the structure alone or together the aligned scores as a JSON.\n" ] }, { "cell_type": "code", - "execution_count": 1, + "execution_count": 4, "id": "a3d66a58-5c19-4b4a-84e6-8909d17592ec", "metadata": {}, "outputs": [ - { - "name": "stdout", - "output_type": "stream", - "text": [ - "To use the Graphein submodule graphein.protein.features.sequence.embeddings, you need to install biovec.\n", - "\n", - "biovec cannot be installed via conda\n", - "To use the Graphein submodule graphein.protein.visualisation, you need to install pytorch3d.\n", - "\n", - "To do so, use the following command:\n", - "\n", - " conda install -c pytorch3d pytorch3d\n", - "To use the Graphein submodule graphein.protein.meshes, you need to install pytorch3d.\n", - "\n", - "To do so, use the following command:\n", - "\n", - " conda install -c pytorch3d pytorch3d\n" - ] - }, { "data": { "text/plain": [ - "('/tmp/AF-Q8W3K0-F1-model_v1 (1).pdb',\n", - " '/tmp/AF-Q8W3K0-F1-predicted_aligned_error_v1 (1).json')" + "('/tmp/Q8W3K0.pdb', '/tmp/Q8W3K0.json')" ] }, - "execution_count": 1, + "execution_count": 4, "metadata": {}, "output_type": "execute_result" } @@ -67,30 +47653,30 @@ "source": [ "from graphein.protein.utils import download_alphafold_structure\n", "\n", - "# Download the PDB file for an exmaple protein (UniProt: Q8W3K0) with the aligned score\n", + "# Download the PDB file for an example protein (UniProt: Q8W3K0) with the aligned score\n", "protein_path = download_alphafold_structure(\"Q8W3K0\", out_dir = \"/tmp\", aligned_score=True)\n", "protein_path" ] }, { "cell_type": "code", - "execution_count": 2, + "execution_count": 5, "id": "5e0f8610-d31a-4380-b20d-17e719b9d83d", "metadata": {}, "outputs": [ { "data": { "text/plain": [ - "'/tmp/AF-Q8W3K0-F1-model_v1 (1).pdb'" + "'/tmp/Q8W3K0.pdb'" ] }, - "execution_count": 2, + "execution_count": 5, "metadata": {}, "output_type": "execute_result" } ], "source": [ - "# Download the PDB file for an exmaple protein (UniProt: Q8W3K0) without the aligned score\n", + "# Download the PDB file for an example protein (UniProt: Q8W3K0) without the aligned score\n", "protein_path = download_alphafold_structure(\"Q8W3K0\", out_dir=\"/tmp\", aligned_score=False)\n", "protein_path" ] @@ -103,42 +47689,55 @@ "## Constructing the Graph\n", "We show a simplified workflow here. For more information and a fuller exposition of the features, please refer to the [Residue Graph Tutorial](https://graphein.ai/notebooks/residue_graphs.html).\n", "\n", - "First, we require a config object." + "First, we require a [config](https://graphein.ai/modules/graphein.protein.html#graphein.protein.config.ProteinGraphConfig) object." ] }, { "cell_type": "code", - "execution_count": 3, + "execution_count": 6, "id": "a4dff4f4-0ba2-40a4-b0bf-458bbe2aa17d", "metadata": {}, "outputs": [ { - "name": "stderr", - "output_type": "stream", - "text": [ - "DEBUG:graphein.protein.graphs:Deprotonating protein. This removes H atoms from the pdb_df dataframe\n", - "DEBUG:graphein.protein.graphs:Detected 1138 total nodes\n", - "DEBUG:graphein.protein.features.nodes.amino_acid:Reading meiler embeddings from: /Users/arianjamasb/github/graphein/graphein/protein/features/nodes/meiler_embeddings.csv\n" - ] - } - ], - "source": [ - "from graphein.protein.config import ProteinGraphConfig\n", - "from graphein.protein.graphs import construct_graph\n", - "\n", - "# Load the default config\n", - "c = ProteinGraphConfig(granularity='CA')\n", - "\n", - "# Construct the graph!\n", - "g = construct_graph(pdb_path=protein_path)" - ] - }, - { - "cell_type": "code", - "execution_count": 4, - "id": "19067deb-f7c1-491f-a196-0b7a3ec9a2e6", - "metadata": {}, - "outputs": [ + "data": { + "text/html": [ + "
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12.059, + 13.265, null, 7.95, 5.583, @@ -97239,25 +144876,28 @@ 11.663, null, 5.583, - 12.059, + 12.16, null, 5.583, - 12.16, + 12.059, null, 5.583, 13.265, null, 5.583, - 9.1, + 3.708, null, 5.583, + 9.1, + null, 3.708, + 12.16, null, 3.708, - 9.1, + 3.534, null, 3.708, - 12.16, + 9.1, null, 3.708, 11.54, @@ -97265,15 +144905,12 @@ 3.708, 6.847, null, - 3.708, 3.534, + 11.54, null, 3.534, 6.847, null, - 3.534, - 11.54, - null, 0.898, 2.264, null, @@ -97281,46 +144918,46 @@ 10.864, null, 13.895, - 15.442, + 11.54, null, 13.895, 9.411, null, 13.895, - 11.54, + 18.326, null, 13.895, + 15.442, + null, + 11.54, 18.326, null, 11.54, 12.16, null, 11.54, - 18.326, + 9.411, null, 11.54, 6.847, null, - 11.54, - 9.411, - null, 14.938, 18.326, null, 12.16, - 18.499, + 13.265, null, 12.16, - 6.847, + 18.499, null, 12.16, - 9.1, + 17.845, null, 12.16, - 13.265, + 9.1, null, 12.16, - 17.845, + 6.847, null, 13.265, 12.059, @@ -97332,37 +144969,37 @@ 16.81, null, 12.059, - 9.1, + 17.845, null, 12.059, 15.118, null, 12.059, - 17.845, + 9.1, null, 11.663, 16.81, null, 11.663, - 9.21, + 14.112, null, 11.663, - 14.112, + 9.21, null, 9.21, 6.816, null, 9.1, - 15.118, + 11.799, null, 9.1, - 18.499, + 6.847, null, 9.1, - 6.847, + 18.499, null, 9.1, - 11.799, + 15.118, null, 9.1, 17.845, @@ -97371,14 +145008,14 @@ 9.283, null, 6.847, - 18.499, - null, - 6.847, 9.411, null, 6.847, 10.056, null, + 6.847, + 18.499, + null, 5.332, 10.864, null, @@ -97389,22 +145026,22 @@ 17.555, null, 18.326, - 15.442, + 18.499, null, 18.326, - 18.499, + 15.442, null, 18.499, 17.845, null, 18.499, - 11.799, + 20.417, null, 18.499, - 10.056, + 11.799, null, 18.499, - 20.417, + 10.056, null, 17.845, 20.417, @@ -97416,25 +145053,25 @@ 19.601, null, 15.118, - 20.417, + 11.799, null, 15.118, 17.43, null, 15.118, - 11.799, + 20.417, null, 11.799, - 10.056, + 13.584, null, 11.799, - 21.562, + 17.43, null, 11.799, - 13.584, + 21.562, null, 11.799, - 17.43, + 10.056, null, 9.283, 7.746, @@ -97458,10 +145095,10 @@ 17.83, null, 15.442, - 17.896, + 21.723, null, 15.442, - 21.723, + 17.896, null, 15.442, 17.83, @@ -97473,43 +145110,43 @@ 23.263, null, 21.723, - 22.285, + 21.638, null, 21.723, - 21.562, + 22.285, null, 21.723, - 17.896, + 21.562, null, 21.723, 25.176, null, 21.723, - 21.638, + 17.896, null, 27.833, - 28.908, + 23.263, null, 27.833, - 23.263, + 28.908, null, 21.562, - 17.43, + 23.155, null, 21.562, - 20.417, + 13.584, null, 21.562, - 23.155, + 20.417, null, 21.562, 25.176, null, 21.562, - 22.285, + 17.43, null, 21.562, - 13.584, + 22.285, null, 20.417, 17.43, @@ -97524,28 +145161,28 @@ 18.67, null, 13.584, - 11.815, + 23.155, null, 13.584, - 23.155, + 14.484, null, 13.584, - 18.67, + 22.285, null, 13.584, - 14.484, + 11.815, null, 13.584, - 22.285, + 18.67, null, 11.815, 17.896, null, 11.815, - 12.653, + 22.285, null, 11.815, - 22.285, + 12.653, null, 9.319, 7.988, @@ -97560,37 +145197,37 @@ 22.732, null, 21.638, - 12.653, + 15.802, null, 21.638, - 22.285, + 23.049, null, 21.638, 22.681, null, 21.638, - 23.049, + 12.653, null, 21.638, - 15.802, + 22.285, null, 23.049, - 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19.623, + 27.211, null, 27.211, 21.082, @@ -99113,13 +146750,16 @@ 24.609, null, 27.211, - 19.623, + 34.05, null, 27.211, - 34.05, + 31.986, null, 27.211, + 19.623, + null, 31.986, + 28.325, null, 31.986, 33.112, @@ -99128,76 +146768,73 @@ 34.05, null, 31.986, - 28.325, - null, - 31.986, 31.896, null, 34.05, 33.112, null, 36.611, - 33.112, + 34.818, null, 36.611, - 24.609, + 39.601, null, 36.611, - 37.754, + 33.112, null, 36.611, - 34.818, + 37.754, null, 36.611, - 39.601, + 24.609, null, 37.754, 30.915, null, 37.754, - 39.601, + 40.919, null, 37.754, - 40.919, + 39.601, null, 37.754, 32.534, null, 42.873, - 44.71, + 44.01, null, 42.873, - 44.01, + 44.71, null, 40.919, - 42.179, + 46.335, null, 40.919, - 40.788, + 39.601, null, 40.919, - 39.601, + 35.526, null, 40.919, 44.71, null, 40.919, - 46.335, + 42.179, null, 40.919, - 35.526, + 40.788, null, 39.696, 39.945, null, 44.01, - 44.71, + 46.335, null, 44.01, 48.559, null, 44.01, - 46.335, + 44.71, null, 40.788, 35.526, @@ -99212,37 +146849,37 @@ 44.438, null, 42.946, - 46.335, + 42.845, null, 42.946, - 48.559, + 37.527, null, 42.946, - 42.845, + 46.335, null, 42.946, - 37.527, + 48.559, null, 40.152, - 26.96, + 41.179, null, 40.152, - 41.179, + 26.96, null, 41.179, - 30.207, + 33.652, null, 41.179, - 33.652, + 30.207, null, 41.366, - 33.652, + 31.353, null, 41.366, 30.207, null, 41.366, - 31.353, + 33.652, null, 43.157, 50.351, @@ -99251,10 +146888,10 @@ 37.527, null, 42.845, - 48.559, + 50.351, null, 42.845, - 50.351, + 48.559, null, 39.342, 34.54, @@ -99269,19 +146906,16 @@ 42.179, null, 35.526, - 30.915, - null, - 35.526, 46.335, null, - 31.976, - 30.734, + 35.526, + 30.915, null, 31.976, 30.207, null, + 31.976, 30.734, - 22.044, null, 30.734, 38.424, @@ -99289,6 +146923,9 @@ 30.734, 21.74, null, + 30.734, + 22.044, + null, 32.534, 34.818, null, @@ -99305,19 +146942,16 @@ 22.044, null, 27.65, - 21.74, - null, - 27.65, 38.424, null, - 28.884, - 31.107, + 27.65, + 21.74, null, 28.884, 34.818, null, - 25.937, - 11.881, + 28.884, + 31.107, null, 25.937, 14.818, @@ -99325,20 +146959,23 @@ 25.937, 18.204, null, + 25.937, + 11.881, + null, 23.369, - 14.818, + 14.994, null, 23.369, - 21.74, + 18.204, null, 23.369, - 22.044, + 14.818, null, 23.369, - 18.204, + 22.044, null, 23.369, - 14.994, + 21.74, null, 24.463, 31.107, @@ -99347,22 +146984,22 @@ 28.325, null, 21.248, - 14.994, + 11.881, null, 21.248, - 14.818, + 14.994, null, 21.248, - 11.881, + 14.818, null, 21.082, - 28.325, + 19.623, null, 21.082, 21.369, null, 21.082, - 19.623, + 28.325, null, 16.067, 15.346, @@ -99371,10 +147008,10 @@ 16.734, null, 16.734, - 14.079, + 13.747, null, 16.734, - 13.747, + 14.079, null, 11.524, 12.701, @@ -99458,10 +147095,10 @@ 29.477, null, 20.702, - 16.443, + 16.081, null, 20.702, - 16.081, + 16.443, null, 20.281, 16.854, @@ -99473,43 +147110,43 @@ 11.622, null, 16.081, - 11.103, + 16.443, null, 16.081, - 16.443, + 11.103, null, 14.812, - 8.792, + 12.153, null, 14.812, - 18.215, + 16.443, null, 14.812, 19.976, null, 14.812, - 12.153, + 18.215, null, 14.812, - 13.365, + 8.792, null, 14.812, 11.103, null, 14.812, - 16.443, + 13.365, null, 11.622, 5.411, null, 11.622, - 11.103, + 7.156, null, 11.622, 5.372, null, 11.622, - 7.156, + 11.103, null, 12.153, 19.976, @@ -99530,23 +147167,23 @@ 0.155, null, 8.792, - 13.365, - null, - 8.792, 7.156, null, 8.792, - 3.735, - null, - 8.792, 5.372, null, 8.792, 11.103, null, 8.792, + 3.735, + null, + 8.792, 10.743, null, + 8.792, + 13.365, + null, 7.156, 5.372, null, @@ -99569,70 +147206,70 @@ 13.365, null, 10.801, - 15.778, + 7.915, null, 10.801, - 2.007, + 13.902, null, 10.801, - 7.915, + 15.778, null, 10.801, - 11.891, + 13.113, null, 10.801, - 13.113, + 11.891, null, 10.801, - 13.902, + 2.007, null, 13.365, - 19.976, + 10.743, null, 13.365, - 10.743, + 19.976, null, 13.365, 16.338, null, 18.215, - 19.976, + 10.743, null, 18.215, - 13.409, + 19.976, null, 18.215, - 10.743, + 16.443, null, 18.215, 23.859, null, 18.215, - 16.443, + 13.409, null, 26.043, - 24.369, + 29.336, null, 26.043, - 29.336, + 24.369, null, 24.369, 23.859, null, 24.369, - 26.599, + 29.336, null, 24.369, - 29.336, + 26.599, null, 18.895, - 20.316, + 15.819, null, 18.895, - 12.636, + 20.316, null, 18.895, - 15.819, + 12.636, null, 16.443, 23.859, @@ -99641,14 +147278,14 @@ 19.976, null, 13.409, - 8.254, - null, - 13.409, 5.824, null, 13.409, 10.743, null, + 13.409, + 8.254, + null, 11.573, 12.636, null, @@ -99659,16 +147296,16 @@ 10.743, null, 8.021, - 8.254, + 3.735, null, 8.021, 1.262, null, 8.021, - 3.735, + 5.824, null, 8.021, - 5.824, + 8.254, null, 8.022, 5.092, @@ -99680,10 +147317,10 @@ 0.155, null, 5.372, - 3.735, + 1.262, null, 5.372, - 1.262, + 3.735, null, 0.155, 1.262, @@ -99692,14 +147329,14 @@ 3.735, null, -3.372, - -1.695, - null, - -3.372, -2.004, null, -3.372, -8.372, null, + -3.372, + -1.695, + null, 1.262, 3.735, null, @@ -99716,55 +147353,55 @@ 8.254, null, 6.844, - 11.263, + 9.839, null, 6.844, - 1.061, + 11.263, null, 6.844, - 9.839, + 1.061, null, 6.844, 4.576, null, 11.263, - 15.251, + 6.951, null, 11.263, - 9.906, + 4.576, null, 11.263, - 6.951, + 15.251, null, 11.263, - 4.576, + 9.839, null, 11.263, - 9.839, + 9.906, null, 13.237, - 17.922, + 21.773, null, 13.237, - 21.773, + 17.922, null, 9.906, 6.951, null, 9.906, - 4.576, + 5.175, null, 9.906, - 5.175, + 4.576, null, 5.175, 8.523, null, 5.175, - 1.246, + 6.951, null, 5.175, - 6.951, + 1.246, null, 1.812, -1.99, @@ -99773,16 +147410,16 @@ -6.895, null, 4.576, - 1.246, + 9.839, null, 4.576, - 9.839, + 1.061, null, 4.576, - 6.951, + 1.246, null, 4.576, - 1.061, + 6.951, null, 1.246, 6.951, @@ -99791,10 +147428,10 @@ -3.341, null, 1.246, - 1.389, + 1.061, null, 1.246, - 1.061, + 1.389, null, 1.246, -4.091, @@ -99803,40 +147440,40 @@ -3.048, null, 1.061, - 1.389, - null, - 1.061, - -3.341, + 6.951, null, 1.061, - 9.839, + 1.389, null, 1.061, 4.967, null, 1.061, - 6.951, - null, - -2.727, -3.341, null, + 1.061, + 9.839, + null, -2.727, - -6.486, + -5.679, null, -2.727, -6.729, null, -2.727, - -5.679, + -6.486, null, -2.727, -4.091, null, + -2.727, + -3.341, + null, -1.223, -6.792, null, -3.048, - -5.679, + -2.303, null, -3.048, 4.967, @@ -99845,19 +147482,19 @@ -3.341, null, -3.048, - -2.303, + -5.679, null, -6.489, - -10.751, + -6.828, null, -6.489, - -6.828, + -10.751, null, -6.792, - -9.434, + -10.198, null, -6.792, - -10.198, + -9.434, null, -10.198, -11.097, @@ -99872,10 +147509,10 @@ -7.129, null, -12.226, - -9.813, + -8.228, null, -12.226, - -8.228, + -9.813, null, -10.751, -9.813, @@ -99917,34 +147554,34 @@ -16.957, null, -3.341, - 1.389, + -2.303, null, -3.341, - -2.303, + 1.389, null, -3.085, - 0.497, + 2.222, null, -3.085, - 2.222, + 0.497, null, -5.679, -6.874, null, -2.303, - 2.007, + 1.389, null, -2.303, - 0.497, + 2.615, null, -2.303, - 2.615, + 2.007, null, -2.303, - 4.967, + 0.497, null, -2.303, - 1.389, + 4.967, null, -3.962, -6.527, @@ -99962,19 +147599,19 @@ 2.615, null, 4.967, - 9.839, + 7.915, null, 4.967, - 7.915, + 9.839, null, 8.254, 10.743, null, 9.839, - 6.951, + 15.251, null, 9.839, - 2.615, + 11.891, null, 9.839, 13.113, @@ -99983,10 +147620,10 @@ 7.915, null, 9.839, - 11.891, + 6.951, null, 9.839, - 15.251, + 2.615, null, 15.819, 22.338, @@ -99995,43 +147632,43 @@ 13.113, null, 15.251, - 17.832, - null, - 15.251, 11.891, null, 15.251, 6.951, null, - 17.922, - 14.805, + 15.251, + 17.832, null, 17.922, 12.816, null, - 16.972, + 17.922, 14.805, null, 16.972, 10.913, null, - 11.891, - 6.951, + 16.972, + 14.805, null, 11.891, - 7.915, + 2.615, null, 11.891, 15.778, null, 11.891, - 17.832, + 7.915, null, 11.891, - 2.615, + 13.113, null, 11.891, - 13.113, + 17.832, + null, + 11.891, + 6.951, null, 10.913, 6.847, @@ -100049,16 +147686,16 @@ 2.007, null, 2.615, - 7.915, + 0.497, null, 2.615, - 0.497, + 7.915, null, 0.497, - 2.007, + 2.222, null, 0.497, - 2.222, + 2.007, null, 2.007, 7.915, @@ -100106,19 +147743,19 @@ 32.407, null, 29.477, - 26.599, + 27.48, null, 29.477, 29.987, null, 29.477, - 27.48, + 26.599, null, 32.407, - 29.778, + 33.351, null, 32.407, - 33.351, + 29.778, null, 33.351, 29.524, @@ -100130,16 +147767,16 @@ 30.144, null, 32.75, - 29.55, + 36.159, null, 32.75, - 36.159, + 29.55, null, 27.48, - 29.987, + 26.599, null, 27.48, - 26.599, + 29.987, null, 27.48, 26.7, @@ -100151,40 +147788,40 @@ 32.751, null, 30.144, - 30.118, + 31.609, null, 30.144, - 39.873, + 36.159, null, 30.144, - 29.987, + 39.873, null, 30.144, - 31.609, + 30.118, null, 30.144, - 36.159, + 29.987, null, 30.118, - 29.55, + 39.873, null, 30.118, - 32.751, + 29.55, null, 30.118, - 39.873, + 32.751, null, 29.55, - 39.873, + 25.852, null, 29.55, - 40.017, + 36.231, null, 29.55, - 36.231, + 39.873, null, 29.55, - 25.852, + 40.017, null, 25.852, 29.809, @@ -100202,10 +147839,10 @@ 42.387, null, 43.478, - 42.387, + 43.624, null, 43.478, - 43.624, + 42.387, null, 40.017, 39.873, @@ -100217,10 +147854,10 @@ 39.009, null, 41.745, - 38.946, + 39.873, null, 41.745, - 39.873, + 38.946, null, 39.009, 41.559, @@ -100232,16 +147869,16 @@ 39.873, null, 38.946, - 31.609, + 41.417, null, 38.946, - 41.417, + 32.751, null, 38.946, 40.301, null, 38.946, - 32.751, + 31.609, null, 36.159, 31.609, @@ -100271,61 +147908,64 @@ 30.596, null, 25.817, - 23.885, - null, - 25.817, 28.039, null, 25.817, 24.144, null, - 29.534, - 30.596, + 25.817, + 23.885, null, 29.534, 34.042, null, - 28.039, + 29.534, 30.596, null, 28.039, + 22.919, + null, + 28.039, 30.8, null, 28.039, - 22.919, + 30.596, null, 28.039, 23.885, null, 31.609, - 34.042, + 41.417, null, 31.609, - 30.8, + 34.042, null, 31.609, 32.751, null, 31.609, - 41.417, + 30.8, null, 31.609, 40.301, null, 30.8, + 32.751, + null, + 30.8, 40.301, null, 30.8, 34.279, null, - 30.8, 32.751, + 40.301, null, 32.751, 39.873, null, - 32.751, - 40.301, + 30.417, + 34.265, null, 30.417, 24.946, @@ -100333,15 +147973,12 @@ 30.417, 22.125, null, - 30.417, 34.265, + 33.398, null, 34.265, 39.973, null, - 34.265, - 33.398, - null, 43.109, 39.973, null, @@ -100364,10 +148001,10 @@ 41.417, null, 41.417, - 34.279, + 35.429, null, 41.417, - 35.429, + 34.279, null, 35.429, 34.042, @@ -100376,25 +148013,25 @@ 34.279, null, 30.596, - 23.885, - null, - 30.596, 24.144, null, 30.596, 27.147, null, + 30.596, + 23.885, + null, 30.098, 22.501, null, 30.098, - 27.147, + 23.181, null, 30.098, - 30.024, + 27.147, null, 30.098, - 23.181, + 30.024, null, 30.098, 22.919, @@ -100409,16 +148046,16 @@ 24.946, null, 30.024, - 22.501, + 21.798, null, 30.024, - 21.798, + 24.997, null, 30.024, - 22.919, + 22.501, null, 30.024, - 24.997, + 22.919, null, 30.024, 30.091, @@ -100433,40 +148070,40 @@ 19.493, null, 26.002, - 24.997, - null, - 26.002, 21.755, null, + 26.002, 24.997, - 21.798, null, 24.997, 19.493, null, + 24.997, + 21.798, + null, 24.52, 25.208, null, 22.501, - 22.919, + 27.147, null, 22.501, - 18.075, + 21.798, null, 22.501, - 19.078, + 23.885, null, 22.501, - 27.147, + 19.078, null, 22.501, - 23.885, + 22.919, null, 22.501, - 21.798, + 18.135, null, 22.501, - 18.135, + 18.075, null, 22.501, 23.181, @@ -100493,16 +148130,16 @@ 14.184, null, 19.712, - 21.755, + 12.577, null, 19.712, - 11.52, + 21.755, null, 19.712, - 12.577, + 11.52, null, 18.135, - 19.078, + 12.577, null, 18.135, 18.075, @@ -100511,19 +148148,19 @@ 17.042, null, 18.135, - 21.798, + 19.078, null, 18.135, - 12.577, + 21.798, null, 18.135, 10.196, null, 19.36, - 22.031, + 26.203, null, 19.36, - 26.203, + 22.031, null, 19.36, 24.338, @@ -100541,26 +148178,26 @@ 13.909, null, 14.184, - 12.577, + 10.196, null, 14.184, - 13.834, + 12.577, null, 14.184, - 10.196, + 13.834, null, 14.184, 8.61, null, 13.834, - 10.568, - null, - 13.834, 7.75, null, 13.834, 8.61, null, + 13.834, + 10.568, + null, 14.856, 21.773, null, @@ -100568,6 +148205,9 @@ 14.461, null, 10.568, + 2.989, + null, + 10.568, 7.75, null, 10.568, @@ -100576,9 +148216,6 @@ 10.568, 10.196, null, - 10.568, - 2.989, - null, 8.962, 14.461, null, @@ -100601,10 +148238,10 @@ 10.895, null, 12.577, - 13.909, + 17.042, null, 12.577, - 17.042, + 13.909, null, 12.577, 17.397, @@ -100616,49 +148253,49 @@ 4.484, null, 11.788, - 9.815, + 9.391, null, 11.788, 12.571, null, 11.788, - 9.391, + 9.815, null, 13.909, 9.815, null, 13.909, - 12.782, + 17.042, null, 13.909, 11.52, null, 13.909, - 17.042, + 12.782, null, 17.042, - 19.493, + 17.397, null, 17.042, 21.755, null, 17.042, - 17.397, + 19.493, null, 15.885, - 18.656, + 12.571, null, 15.885, - 12.571, + 18.656, null, 15.885, 9.391, null, 15.029, - 9.391, + 12.782, null, 15.029, - 12.782, + 9.391, null, 15.029, 9.815, @@ -100691,10 +148328,10 @@ 16.168, null, 18.656, - 12.571, + 19.493, null, 18.656, - 19.493, + 12.571, null, 17.655, 5.221, @@ -100703,19 +148340,19 @@ 9.391, null, 10.895, - 14.321, + 4.822, null, 10.895, - 4.822, + 14.321, null, 10.895, 12.823, null, 12.823, - 2.58, + 8.315, null, 12.823, - 8.315, + 2.58, null, 16.168, 19.493, @@ -100730,13 +148367,13 @@ 19.667, null, 17.397, - 21.798, + 9.995, null, 17.397, 19.078, null, 17.397, - 9.995, + 21.798, null, 18.181, 22.125, @@ -100745,29 +148382,29 @@ 7.93, null, 21.975, - 22.125, - null, - 21.975, 24.946, null, - 21.798, - 19.078, + 21.975, + 22.125, null, 21.798, 22.919, null, - 19.667, + 21.798, 19.078, null, 19.667, 9.995, null, - 22.919, - 23.885, + 19.667, + 19.078, null, 22.919, 19.078, null, + 22.919, + 23.885, + null, 19.078, 18.075, null, @@ -100781,13 +148418,13 @@ 4.375, null, 4.375, - 8.315, + -3.788, null, 4.375, 0.934, null, 4.375, - -3.788, + 8.315, null, 0.934, -6.908, @@ -100820,10 +148457,10 @@ 30.207, null, 26.203, - 25.208, + 22.031, null, 26.203, - 22.031, + 25.208, null, 27.768, 31.353, @@ -100841,106 +148478,106 @@ 14.722, null, 13.17, - 12.111, + 14.188, null, 13.17, - 14.188, + 12.111, null, 14.188, 21.063, null, 17.142, - 19.04, + 13.284, null, 17.142, 12.111, null, 17.142, - 15.13, + 19.04, null, 17.142, - 13.284, - null, - 14.722, - 11.52, + 15.13, null, 14.722, 8.61, null, - 12.111, - 13.284, + 14.722, + 11.52, null, 12.111, 7.265, null, 12.111, - 7.236, + 8.971, null, 12.111, 15.13, null, 12.111, - 8.971, + 7.236, + null, + 12.111, + 13.284, null, 7.75, 8.61, null, 7.75, - 7.236, + 2.989, null, 7.75, - 2.989, + 7.236, null, 7.236, - 1.203, + 8.971, null, 7.236, 7.265, null, 7.236, - 8.971, + 1.203, null, 7.265, 13.284, null, 7.265, - 9.712, + 8.971, null, 7.265, 15.13, null, 7.265, - 8.971, + 1.203, null, 7.265, - 1.203, + 9.712, null, 7.761, - 10.918, + 13.273, null, 7.761, - 13.273, + 10.918, null, 9.712, - 9.873, + 15.13, null, 9.712, - 13.284, + 9.873, null, 9.712, - 2.84, + 13.284, null, 9.712, - 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-16.229, + -21.115, null, -18.612, -25.237, @@ -102860,52 +150497,52 @@ -27.59, null, -27.59, - -21.115, + -24.355, null, -27.59, - -24.355, + -21.115, null, -23.635, -20.077, null, -21.115, - -21.559, + -16.929, null, -21.115, -24.355, null, -21.115, - -16.929, + -16.229, null, -21.115, - -18.326, + -21.559, null, -21.115, - -16.229, + -18.326, null, -18.326, -16.929, null, -18.326, - -6.872, + -11.829, null, -18.326, - -11.829, + -8.206, null, -18.326, -16.229, null, -18.326, - -21.559, + -10.074, null, -18.326, - -10.074, + -21.559, null, -18.326, - -10.195, + -6.872, null, -18.326, - -8.206, + -10.195, null, -20.077, -13.902, @@ -102914,19 +150551,19 @@ -14.551, null, -16.229, - -8.893, + -10.195, null, -16.229, - -16.929, + -11.829, null, -16.229, - -11.829, + -16.929, null, -16.229, -12.566, null, -16.229, - -10.195, + -8.893, null, -14.551, -14.588, @@ -102947,13 +150584,13 @@ -11.829, null, -11.829, - -6.872, + -16.929, null, -11.829, -10.074, null, -11.829, - -16.929, + -6.872, null, -11.829, -10.195, @@ -102962,25 +150599,25 @@ -21.965, null, -16.929, - -21.559, + -15.076, null, -16.929, -10.074, null, -16.929, - -15.076, + -24.317, null, -16.929, - -24.317, + -21.559, null, -24.355, - -21.965, + -21.559, null, -24.355, -24.317, null, -24.355, - -21.559, + -21.965, null, -27.353, -24.573, @@ -102989,10 +150626,10 @@ -22.295, null, -21.559, - -24.317, + -19.145, null, -21.559, - -19.145, + -24.317, null, -19.479, -17.904, @@ -103001,10 +150638,10 @@ -8.206, null, -10.195, - -6.904, + -6.872, null, -10.195, - -6.872, + -6.904, null, -6.872, -10.074, @@ -103016,19 +150653,19 @@ -4.69, null, -10.074, - -4.69, + -7.884, null, -10.074, -8.206, null, -10.074, - -7.884, + -4.69, null, -10.074, - -19.145, + -15.076, null, -10.074, - -15.076, + -19.145, null, -15.076, -21.965, @@ -103037,14 +150674,14 @@ -13.002, null, -15.076, - -7.884, - null, - -15.076, -19.145, null, -15.076, -24.317, null, + -15.076, + -7.884, + null, -16.957, -9.5, null, @@ -103055,91 +150692,88 @@ -24.317, null, -24.317, - -21.154, + -19.145, null, -24.317, - -19.145, + -21.154, null, -24.573, -21.023, null, -19.145, - -14.449, + -9.147, null, -19.145, - -9.147, + -7.884, null, -19.145, -14.797, null, -19.145, - -13.002, + -21.154, null, -19.145, - -7.884, + -14.449, null, -19.145, - -8.206, + -13.002, null, -19.145, - -21.154, + -8.206, null, -14.449, - -14.797, + -9.147, null, -14.449, - -4.985, + -14.797, null, -14.449, -8.206, null, -14.449, - -9.147, - null, - -8.206, -4.985, null, -8.206, -4.751, null, -8.206, + -4.985, + null, + -8.206, -4.69, null, -4.751, -2.773, null, -4.69, - -7.884, - null, - -4.69, -4.985, null, -4.69, -2.51, null, + -4.69, -7.884, - -13.002, null, -7.884, -9.147, null, -7.884, + -2.51, + null, + -7.884, -5.691, null, -7.884, - -2.51, + -13.002, null, -9.696, -7.335, null, -13.002, - -5.691, - null, - -13.002, -21.154, null, -13.002, - -14.883, + -5.691, null, -13.002, -12.986, @@ -103147,44 +150781,47 @@ -13.002, -10.599, null, + -13.002, + -14.883, + null, -17.817, -22.635, null, -21.154, - -12.986, + -14.883, null, -21.154, - -14.883, + -12.986, null, -21.023, -17.792, null, -17.792, - -11.875, + -8.184, null, -17.792, - -8.184, + -11.875, null, -14.883, -8.678, null, -14.883, - -5.691, + -12.986, null, -14.883, - -9.147, + -5.63, null, -14.883, - -5.63, + -10.599, null, -14.883, - -14.797, + -5.691, null, -14.883, - -10.599, + -9.147, null, -14.883, - -12.986, + -14.797, null, -14.797, -9.147, @@ -103196,13 +150833,13 @@ -6.881, null, -9.147, - -2.51, + -5.63, null, -9.147, -4.985, null, -9.147, - -5.63, + -2.51, null, -6.022, -1.234, @@ -103223,6 +150860,9 @@ -8.678, null, -5.691, + -10.599, + null, + -5.691, -3.586, null, -5.691, @@ -103231,20 +150871,17 @@ -5.691, -5.63, null, - -5.691, - -10.599, - null, -10.599, -7.848, null, -10.599, - -3.586, + -12.986, null, -10.599, -8.678, null, -10.599, - -12.986, + -3.586, null, -11.994, -11.792, @@ -103262,13 +150899,13 @@ -12.18, null, -8.678, - -3.586, + -7.848, null, -8.678, -5.63, null, -8.678, - -7.848, + -3.586, null, -11.179, -8.184, @@ -103283,10 +150920,10 @@ -3.586, null, -1.183, - -3.586, + 1.886, null, -1.183, - 1.886, + -3.586, null, -3.586, -7.848, @@ -104158,16 +151795,17 @@ } ], "source": [ - "from graphein.protein.edges.distance import add_aromatic_interactions, add_cation_pi_interactions, add_hydrophobic_interactions, add_ionic_interactions\n", - "\n", - "config = ProteinGraphConfig(edge_construction_functions=[add_aromatic_interactions,\n", - " add_cation_pi_interactions,\n", - " add_hydrophobic_interactions,\n", - " add_ionic_interactions])\n", + "config = gp.ProteinGraphConfig(edge_construction_functions=[\n", + " gp.add_aromatic_interactions,\n", + " gp.add_cation_pi_interactions,\n", + " gp.add_hydrophobic_interactions,\n", + " gp.add_ionic_interactions\n", + " ]\n", + ")\n", "\n", - "g = construct_graph(pdb_path=protein_path, config=config)\n", + "g = gp.construct_graph(pdb_path=protein_path, config=config)\n", "\n", - "plotly_protein_structure_graph(g, colour_edges_by=\"kind\", colour_nodes_by=\"residue_name\", label_node_ids=False, node_size_multiplier=2, node_size_min=5)" + "gp.plotly_protein_structure_graph(g, colour_edges_by=\"kind\", colour_nodes_by=\"residue_name\", label_node_ids=False, node_size_multiplier=2, node_size_min=5)" ] }, { @@ -104175,16 +151813,16 @@ "id": "68eaf9c9-410f-45a8-932a-92d3387712b8", "metadata": {}, "source": [ - "You can also check out our [Residue Graph Tutorial](https://graphein.ai/notebooks/residue_graphs.html) for more customisation options!! For more details on visualisation, please refer to the [interactive visualisation tutorial](https://graphein.ai/notebooks/interactive_plotlY_examples.html)." + "You can also check out our [Residue Graph Tutorial](https://graphein.ai/notebooks/residue_graphs.html) for more customisation options!! For more details on visualisation, please refer to the [interactive visualisation tutorial](https://graphein.ai/notebooks/interactive_plotlY_examples.html) or the [documentation](https://graphein.ai/modules/graphein.protein.html#module-graphein.protein.visualisation)." ] } ], "metadata": { "interpreter": { - "hash": "2084dd4fc0c9f9186ef9bb5d9f5c6652432726a285d6ac2dcf2b1a616ab39cbb" + "hash": "0ab7f988027852efc1ebacd06db3f130eb65d2a20cb6a366311359132c20a952" }, "kernelspec": { - "display_name": "graphein-dev", + "display_name": "Python 3.8.13 ('graphein')", "language": "python", "name": "python3" }, @@ -104198,7 +151836,7 @@ "name": "python", "nbconvert_exporter": "python", "pygments_lexer": "ipython3", - "version": "3.8.12" + "version": "3.8.13" } }, "nbformat": 4, diff --git a/notebooks/higher_order_graphs.ipynb b/notebooks/higher_order_graphs.ipynb index 161f1642..c7990b36 100644 --- a/notebooks/higher_order_graphs.ipynb +++ b/notebooks/higher_order_graphs.ipynb @@ -5,11 +5,11 @@ "metadata": {}, "source": [ "# Secondary Structure Graphs & Chain Graphs\n", - "In this tutorial, we'll be looking at higher-order graphs - that is graphs of Secondary Structure Elements and interacting chains ([quaternary structure](https://en.wikipedia.org/wiki/Protein_quaternary_structure)) - as well as assorted visualisation tools.\n", + "In this tutorial, we'll be looking at higher-order graphs - that is graphs of Secondary Structure Elements and interacting chains (quaternary structure) - as well as assorted visualisation tools.\n", "\n", "Graphein provides utilities for computing these graphs from residue-level graphs. I'd recommend checking out [this tutorial]() for more information.\n", "\n", - "[![Open In Colab](https://colab.research.google.com/assets/colab-badge.svg)](https://colab.research.google.com/github/a-r-j/graphein/blob/master/notebooks/higher_order_graphs.ipynb) [![GitHub](https://img.shields.io/badge/-View%20on%20GitHub-181717?logo=github&logoColor=ffffff)](https://github.com/a-r-j/graphein/blob/master/notebooks/higher_order_graphs.ipynb)\n", + "[![Open In Colab](https://colab.research.google.com/assets/colab-badge.svg)](https://colab.research.google.com/github/a-r-j/graphein/blob/master/notebooks/higher_order_graphs.ipynb)\n", "\n", "\n", "First, we'll construct a graph to work with\n", @@ -35,15 +35,46 @@ "metadata": {}, "outputs": [ { - "name": "stderr", - "output_type": "stream", - "text": [ - "INFO:graphein.protein.edges.distance:Found 208 hbond interactions.\n", - "INFO:graphein.protein.edges.distance:Found 12 hbond interactions.\n", - "INFO:graphein.protein.edges.distance:Found 6 disulfide interactions.\n", - "INFO:graphein.protein.edges.distance:Found 4566 ionic interactions.\n", - "INFO:graphein.protein.edges.distance:Found: 84 aromatic-aromatic interactions\n" - ] + "data": { + "text/html": [ + "
Reading PDB file...         ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ 100% 0:00:00\n",
+       "Processing PDB dataframe... ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ 100% 0:00:00\n",
+       "Initializing graph...       ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ 100% 0:00:00\n",
+       "Constructing edges...       ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━   0% -:--:--\n",
+       "
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0.359688, + 0.494877, + 0.01199, + 0.657865, 1 ], [ - 0.901807, - 0.425087, - 0.359688, + 0.494877, + 0.01199, + 0.657865, 1 ], [ - 0.901807, - 0.425087, - 0.359688, + 0.494877, + 0.01199, + 0.657865, 1 ], [ - 0.901807, - 0.425087, - 0.359688, + 0.494877, + 0.01199, + 0.657865, 1 ], [ - 0.901807, - 0.425087, - 0.359688, + 0.494877, + 0.01199, + 0.657865, 1 ] ], @@ -18729,9 +18760,9 @@ "peptide_bond / ionic", "peptide_bond / ionic", "peptide_bond / ionic", - "hbond / ionic", - "hbond / ionic", - "hbond / ionic", + "ionic / hbond", + "ionic / hbond", + "ionic / hbond", "hbond", "hbond", "hbond", @@ -18741,9 +18772,9 @@ "peptide_bond", "peptide_bond", "peptide_bond", - "hbond / ionic", - "hbond / ionic", - "hbond / ionic", + "ionic / hbond", + "ionic / hbond", + "ionic / hbond", "peptide_bond", "peptide_bond", "peptide_bond", @@ -18894,9 +18925,9 @@ "peptide_bond", "peptide_bond", "peptide_bond", - "peptide_bond / aromatic", - "peptide_bond / aromatic", - "peptide_bond / aromatic", + "aromatic / peptide_bond", + "aromatic / peptide_bond", + "aromatic / peptide_bond", "peptide_bond", "peptide_bond", "peptide_bond", @@ -19038,9 +19069,9 @@ "peptide_bond", "peptide_bond", "peptide_bond", - "hbond / ionic", - "hbond / ionic", - "hbond / ionic", + "ionic / hbond", + "ionic / hbond", + "ionic / hbond", "ionic", "ionic", "ionic", @@ -19386,9 +19417,9 @@ "peptide_bond", "peptide_bond", "peptide_bond", - "peptide_bond / aromatic", - "peptide_bond / aromatic", - "peptide_bond / aromatic", + "aromatic / peptide_bond", + "aromatic / peptide_bond", + "aromatic / peptide_bond", "peptide_bond", "peptide_bond", "peptide_bond", @@ -19653,12 +19684,12 @@ "peptide_bond", "peptide_bond", "peptide_bond", - "peptide_bond / aromatic", - "peptide_bond / aromatic", - "peptide_bond / aromatic", - "peptide_bond / aromatic", - "peptide_bond / aromatic", - "peptide_bond / aromatic", + "aromatic / peptide_bond", + "aromatic / peptide_bond", + "aromatic / peptide_bond", + "aromatic / peptide_bond", + "aromatic / peptide_bond", + "aromatic / peptide_bond", "peptide_bond", "peptide_bond", "peptide_bond", @@ -19767,18 +19798,18 @@ "peptide_bond / ionic", "peptide_bond / ionic", "peptide_bond / ionic", + "ionic / hbond", + "ionic / hbond", + "ionic / hbond", "hbond", "hbond", "hbond", - "hbond / ionic", - "hbond / ionic", - "hbond / ionic", "peptide_bond", "peptide_bond", "peptide_bond", - "hbond / ionic", - "hbond / ionic", - "hbond / ionic", + "ionic / hbond", + "ionic / hbond", + "ionic / hbond", "peptide_bond", "peptide_bond", "peptide_bond", @@ -19929,9 +19960,9 @@ "peptide_bond", "peptide_bond", "peptide_bond", - "peptide_bond / aromatic", - "peptide_bond / aromatic", - "peptide_bond / aromatic", + "aromatic / peptide_bond", + "aromatic / peptide_bond", + "aromatic / peptide_bond", "peptide_bond", "peptide_bond", "peptide_bond", @@ -19983,9 +20014,9 @@ "peptide_bond", "peptide_bond", "peptide_bond", - "hbond / ionic", - "hbond / ionic", - "hbond / ionic", + "ionic / hbond", + "ionic / hbond", + "ionic / hbond", "peptide_bond", "peptide_bond", "peptide_bond", @@ -20070,9 +20101,9 @@ "peptide_bond", "peptide_bond", "peptide_bond", - "hbond / ionic", - "hbond / ionic", - "hbond / ionic", + "ionic / hbond", + "ionic / hbond", + "ionic / hbond", "ionic", "ionic", "ionic", @@ -20331,9 +20362,9 @@ "peptide_bond", "peptide_bond", "peptide_bond", - "hbond / ionic", - "hbond / ionic", - "hbond / ionic", + "ionic / hbond", + "ionic / hbond", + "ionic / hbond", "peptide_bond", "peptide_bond", "peptide_bond", @@ -20406,9 +20437,9 @@ "ionic", "ionic", "ionic", - "peptide_bond / aromatic", - "peptide_bond / aromatic", - "peptide_bond / aromatic", + "aromatic / peptide_bond", + "aromatic / peptide_bond", + "aromatic / peptide_bond", "peptide_bond", "peptide_bond", "peptide_bond", @@ -20667,9 +20698,9 @@ "peptide_bond", "peptide_bond", "peptide_bond", - "peptide_bond / aromatic", - "peptide_bond / aromatic", - "peptide_bond / aromatic", + "aromatic / peptide_bond", + "aromatic / peptide_bond", + "aromatic / peptide_bond", "peptide_bond", "peptide_bond", "peptide_bond", @@ -20875,10 +20906,10 @@ 17.589, null, 20.575, - 16.706, + 27.174, null, 20.575, - 27.174, + 16.706, null, 17.589, 15.328, @@ -21394,10 +21425,10 @@ 17.138, null, 21.567, - 27.064, + 25.023, null, 21.567, - 25.023, + 27.064, null, 18.339, 16.289, @@ -21631,10 +21662,10 @@ 0.08, null, -2.308, - -7.082, + -0.223, null, -2.308, - -0.223, + -7.082, null, 0.08, 2.264, @@ -21823,10 +21854,10 @@ -17.103, null, -16.09, - -15.443, + -10.843, null, -16.09, - -10.843, + -15.443, null, -17.103, -20.439, @@ -21913,10 +21944,10 @@ -17.46, null, -20.638, - -16.706, + -27.157, null, -20.638, - -27.157, + -16.706, null, -17.46, -15.24, @@ -22411,10 +22442,10 @@ -24.955, null, -21.6, - -27.076, + -17.026, null, -21.6, - -17.026, + -27.076, null, -18.269, -16.186, @@ -22648,10 +22679,10 @@ -0.657, null, 2.076, - 0.244, + 7.054, null, 2.076, - 7.054, + 0.244, null, -0.657, -2.489, @@ -22929,10 +22960,10 @@ 1.092, null, 0.021, - -3.885, + 3.032, null, 0.021, - 3.032, + -3.885, null, 1.092, 0.075, @@ -23448,10 +23479,10 @@ 2.392, null, -1.493, - -3.366, + -0.593, null, -1.493, - -0.593, + -3.366, null, -2.622, -2.225, @@ -23685,10 +23716,10 @@ -10.591, null, -12.076, - -13.26, + -6.51, null, -12.076, - -6.51, + -13.26, null, -10.591, -8.159, @@ -23877,10 +23908,10 @@ 19.561, null, 17.056, - 12.245, + 11.346, null, 17.056, - 11.346, + 12.245, null, 19.561, 19.567, @@ -23967,10 +23998,10 @@ 1.158, null, 0.028, - -3.791, + 3.218, null, 0.028, - 3.218, + -3.791, null, 1.158, 0.036, @@ -24465,10 +24496,10 @@ -0.497, null, -1.628, - -3.136, + 2.243, null, -1.628, - 2.243, + -3.136, null, -2.901, -2.309, @@ -24702,10 +24733,10 @@ -10.83, null, -12.17, - -6.637, + -13.167, null, -12.17, - -13.167, + -6.637, null, -10.83, -8.095, @@ -24983,10 +25014,10 @@ -9.707, null, -11.753, - -9.384, + -3.686, null, -11.753, - -3.686, + -9.384, null, -9.707, -12.594, @@ -25502,10 +25533,10 @@ 11.41, null, 12.736, - 4.194, + 2.641, null, 12.736, - 2.641, + 4.194, null, 11.197, 14.403, @@ -25739,10 +25770,10 @@ 23.184, null, 20.721, - 13.817, + 19.374, null, 20.721, - 19.374, + 13.817, null, 23.184, 21.581, @@ -25931,10 +25962,10 @@ -2.483, null, -5.44, - -4.719, + -2.937, null, -5.44, - -2.937, + -4.719, null, -2.483, -3.523, @@ -26021,10 +26052,10 @@ 9.5, null, 11.636, - 9.173, + 3.684, null, 11.636, - 3.684, + 9.173, null, 9.5, 12.46, @@ -26519,10 +26550,10 @@ -2.73, null, -12.73, - -4.425, + -11.337, null, -12.73, - -11.337, + -4.425, null, -11.078, -14.163, @@ -26756,10 +26787,10 @@ -23.618, null, -21.195, - -19.58, + -14.05, null, -21.195, - -14.05, + -19.58, null, -23.618, -21.711, @@ -27798,8 +27829,8 @@ "\n", "import graphein.protein as gp\n", "\n", - "new_funcs = {\"keep_hets\": False,\n", - " \"edge_construction_functions\": [gp.add_peptide_bonds,\n", + "new_funcs = {\n", + " \"edge_construction_functions\": [gp.add_peptide_bonds,\n", " gp.add_hydrogen_bond_interactions,\n", " gp.add_disulfide_interactions,\n", " gp.add_ionic_interactions,\n", @@ -27818,7 +27849,7 @@ "metadata": {}, "source": [ "## Secondary Structure Graphs\n", - "We use [DSSP](https://en.wikipedia.org/wiki/DSSP_(hydrogen_bond_estimation_algorithm)) to compute secondary structures. This is stored under `d[\"ss\"]` in the node attributes. Eg:" + "We use [DSSP] to compute secondary structures. This is stored under `d[\"ss\"]` in the node attributes. Eg:" ] }, { @@ -27826,17 +27857,6 @@ "execution_count": 3, "metadata": {}, "outputs": [ - { - "name": "stderr", - "output_type": "stream", - "text": [ - "/Users/arianjamasb/opt/anaconda3/envs/graphein-wip/lib/python3.8/site-packages/biopandas/pdb/pandas_pdb.py:554: UserWarning:\n", - "\n", - "Column node_id is not an expected column and will be skipped.\n", - "\n", - "INFO:graphein.protein.utils:Successfully saved PDB dataframe to /var/folders/p1/0qtk6t_520n7k4bvk1p26l_w0000gn/T/tmp4ltkgd3l/4hhb.pdb\n" - ] - }, { "name": "stdout", "output_type": "stream", @@ -27860,6 +27880,28 @@ "H\n", "T\n" ] + }, + { + "name": "stderr", + "output_type": "stream", + "text": [ + "/Users/arianjamasb/opt/anaconda3/envs/graphein-wip/lib/python3.8/site-packages/biopandas/pdb/pandas_pdb.py:624: UserWarning:\n", + "\n", + "Column model_id is not an expected column and will be skipped.\n", + "\n", + "/Users/arianjamasb/opt/anaconda3/envs/graphein-wip/lib/python3.8/site-packages/biopandas/pdb/pandas_pdb.py:624: UserWarning:\n", + "\n", + "Column node_id is not an expected column and will be skipped.\n", + "\n", + "/Users/arianjamasb/opt/anaconda3/envs/graphein-wip/lib/python3.8/site-packages/biopandas/pdb/pandas_pdb.py:624: UserWarning:\n", + "\n", + "Column model_id is not an expected column and will be skipped.\n", + "\n", + "/Users/arianjamasb/opt/anaconda3/envs/graphein-wip/lib/python3.8/site-packages/biopandas/pdb/pandas_pdb.py:624: UserWarning:\n", + "\n", + "Column node_id is not an expected column and will be skipped.\n", + "\n" + ] } ], "source": [ @@ -27888,695 +27930,702 @@ "name": "stdout", "output_type": "stream", "text": [ - "Name: 4hhb\n", - "Type: MultiGraph\n", - "Number of nodes: 80\n", - "Number of edges: 107\n", - "Average degree: 2.6750\n", - "A:VAL:1 A:LEU:2 {'kind': {'peptide_bond'}}\n", - "A:LEU:2 A:SER:3 {'kind': {'peptide_bond'}}\n", - "A:SER:3 A:PRO:4 {'kind': {'peptide_bond'}}\n", - "A:SER:3 A:ASP:6 {'kind': {'hbond'}}\n", - "A:PRO:4 A:ALA:5 {'kind': {'peptide_bond'}}\n", - "A:ALA:5 A:ASP:6 {'kind': {'peptide_bond'}}\n", - "A:ASP:6 A:LYS:7 {'kind': {'peptide_bond', 'ionic'}}\n", - "A:ASP:6 A:LYS:127 {'kind': {'hbond', 'ionic'}}\n", - "A:ASP:6 A:SER:124 {'kind': {'hbond'}}\n", - "A:ASP:6 C:ARG:141 {'kind': {'ionic'}}\n", - "A:LYS:7 A:THR:8 {'kind': {'peptide_bond'}}\n", - "A:LYS:7 A:ASP:74 {'kind': {'hbond', 'ionic'}}\n", - "A:THR:8 A:ASN:9 {'kind': {'peptide_bond'}}\n", - "A:ASN:9 A:VAL:10 {'kind': {'peptide_bond'}}\n", - "A:VAL:10 A:LYS:11 {'kind': {'peptide_bond'}}\n", - "A:LYS:11 A:ALA:12 {'kind': {'peptide_bond'}}\n", - "A:LYS:11 A:ASP:74 {'kind': {'ionic'}}\n", - "A:ALA:12 A:ALA:13 {'kind': {'peptide_bond'}}\n", - "A:ALA:13 A:TRP:14 {'kind': {'peptide_bond'}}\n", - "A:TRP:14 A:GLY:15 {'kind': {'peptide_bond'}}\n", - "A:GLY:15 A:LYS:16 {'kind': {'peptide_bond'}}\n", - "A:LYS:16 A:VAL:17 {'kind': {'peptide_bond'}}\n", - "A:LYS:16 A:GLU:116 {'kind': {'ionic'}}\n", - "A:VAL:17 A:GLY:18 {'kind': {'peptide_bond'}}\n", - "A:GLY:18 A:ALA:19 {'kind': {'peptide_bond'}}\n", - "A:ALA:19 A:HIS:20 {'kind': {'peptide_bond'}}\n", - "A:HIS:20 A:ALA:21 {'kind': {'peptide_bond'}}\n", - "A:HIS:20 A:GLU:23 {'kind': {'ionic'}}\n", - "A:HIS:20 A:HIS:112 {'kind': {'aromatic'}}\n", - "A:ALA:21 A:GLY:22 {'kind': {'peptide_bond'}}\n", - "A:GLY:22 A:GLU:23 {'kind': {'peptide_bond'}}\n", - "A:GLU:23 A:TYR:24 {'kind': {'peptide_bond'}}\n", - "A:GLU:23 A:HIS:112 {'kind': {'ionic'}}\n", - "A:TYR:24 A:GLY:25 {'kind': {'peptide_bond'}}\n", - "A:GLY:25 A:ALA:26 {'kind': {'peptide_bond'}}\n", - "A:ALA:26 A:GLU:27 {'kind': {'peptide_bond'}}\n", - "A:GLU:27 A:ALA:28 {'kind': {'peptide_bond'}}\n", - "A:GLU:27 A:ARG:31 {'kind': {'ionic'}}\n", - "A:GLU:27 A:HIS:112 {'kind': {'ionic'}}\n", - "A:ALA:28 A:LEU:29 {'kind': {'peptide_bond'}}\n", - "A:LEU:29 A:GLU:30 {'kind': {'peptide_bond'}}\n", - "A:GLU:30 A:ARG:31 {'kind': {'peptide_bond', 'ionic'}}\n", - "A:GLU:30 A:HIS:50 {'kind': {'ionic'}}\n", - "A:ARG:31 A:MET:32 {'kind': {'peptide_bond'}}\n", - "A:MET:32 A:PHE:33 {'kind': {'peptide_bond'}}\n", - "A:PHE:33 A:LEU:34 {'kind': {'peptide_bond'}}\n", - "A:PHE:33 A:PHE:43 {'kind': {'aromatic'}}\n", - "A:LEU:34 A:SER:35 {'kind': {'peptide_bond'}}\n", - "A:SER:35 A:PHE:36 {'kind': {'peptide_bond'}}\n", - "A:PHE:36 A:PRO:37 {'kind': {'peptide_bond'}}\n", - "A:PHE:36 A:HIS:103 {'kind': {'aromatic'}}\n", - "A:PRO:37 A:THR:38 {'kind': {'peptide_bond'}}\n", - "A:THR:38 A:THR:39 {'kind': {'peptide_bond'}}\n", - "A:THR:39 A:LYS:40 {'kind': {'peptide_bond'}}\n", - "A:LYS:40 A:THR:41 {'kind': {'peptide_bond'}}\n", - "A:THR:41 A:TYR:42 {'kind': {'peptide_bond'}}\n", - "A:TYR:42 A:PHE:43 {'kind': {'peptide_bond'}}\n", - "A:TYR:42 D:ASP:99 {'kind': {'hbond'}}\n", - "A:PHE:43 A:PRO:44 {'kind': {'peptide_bond'}}\n", - "A:PHE:43 A:HIS:58 {'kind': {'aromatic'}}\n", - "A:PHE:43 A:PHE:46 {'kind': {'aromatic'}}\n", - "A:PRO:44 A:HIS:45 {'kind': {'peptide_bond'}}\n", - "A:HIS:45 A:PHE:46 {'kind': {'peptide_bond', 'aromatic'}}\n", - "A:PHE:46 A:ASP:47 {'kind': {'peptide_bond'}}\n", - "A:PHE:46 A:HIS:58 {'kind': {'aromatic'}}\n", - "A:ASP:47 A:LEU:48 {'kind': {'peptide_bond'}}\n", - "A:ASP:47 A:SER:49 {'kind': {'hbond'}}\n", - "A:LEU:48 A:SER:49 {'kind': {'peptide_bond'}}\n", - "A:SER:49 A:HIS:50 {'kind': {'peptide_bond'}}\n", - "A:HIS:50 A:GLY:51 {'kind': {'peptide_bond'}}\n", - "A:GLY:51 A:SER:52 {'kind': {'peptide_bond'}}\n", - "A:SER:52 A:ALA:53 {'kind': {'peptide_bond'}}\n", - "A:ALA:53 A:GLN:54 {'kind': {'peptide_bond'}}\n", - "A:GLN:54 A:VAL:55 {'kind': {'peptide_bond'}}\n", - "A:VAL:55 A:LYS:56 {'kind': {'peptide_bond'}}\n", - "A:LYS:56 A:GLY:57 {'kind': {'peptide_bond'}}\n", - "A:GLY:57 A:HIS:58 {'kind': {'peptide_bond'}}\n", - "A:HIS:58 A:GLY:59 {'kind': {'peptide_bond'}}\n", - "A:GLY:59 A:LYS:60 {'kind': {'peptide_bond'}}\n", - "A:LYS:60 A:LYS:61 {'kind': {'peptide_bond'}}\n", - "A:LYS:60 A:ASP:64 {'kind': {'ionic'}}\n", - "A:LYS:61 A:VAL:62 {'kind': {'peptide_bond'}}\n", - "A:LYS:61 A:ASP:64 {'kind': {'ionic'}}\n", - "A:VAL:62 A:ALA:63 {'kind': {'peptide_bond'}}\n", - "A:ALA:63 A:ASP:64 {'kind': {'peptide_bond'}}\n", - "A:ASP:64 A:ALA:65 {'kind': {'peptide_bond'}}\n", - "A:ALA:65 A:LEU:66 {'kind': {'peptide_bond'}}\n", - "A:LEU:66 A:THR:67 {'kind': {'peptide_bond'}}\n", - "A:THR:67 A:ASN:68 {'kind': {'peptide_bond'}}\n", - "A:ASN:68 A:ALA:69 {'kind': {'peptide_bond'}}\n", - "A:ALA:69 A:VAL:70 {'kind': {'peptide_bond'}}\n", - "A:VAL:70 A:ALA:71 {'kind': {'peptide_bond'}}\n", - "A:ALA:71 A:HIS:72 {'kind': {'peptide_bond'}}\n", - "A:HIS:72 A:VAL:73 {'kind': {'peptide_bond'}}\n", - "A:HIS:72 A:ASP:75 {'kind': {'ionic'}}\n", - "A:VAL:73 A:ASP:74 {'kind': {'peptide_bond'}}\n", - "A:ASP:74 A:ASP:75 {'kind': {'peptide_bond'}}\n", - "A:ASP:75 A:MET:76 {'kind': {'peptide_bond'}}\n", - "A:ASP:75 A:ASN:78 {'kind': {'hbond'}}\n", - "A:MET:76 A:PRO:77 {'kind': {'peptide_bond'}}\n", - "A:PRO:77 A:ASN:78 {'kind': {'peptide_bond'}}\n", - "A:ASN:78 A:ALA:79 {'kind': {'peptide_bond'}}\n", - "A:ALA:79 A:LEU:80 {'kind': {'peptide_bond'}}\n", - "A:LEU:80 A:SER:81 {'kind': {'peptide_bond'}}\n", - "A:SER:81 A:ALA:82 {'kind': {'peptide_bond'}}\n", - "A:SER:81 A:LYS:139 {'kind': {'hbond'}}\n", - "A:ALA:82 A:LEU:83 {'kind': {'peptide_bond'}}\n", - "A:LEU:83 A:SER:84 {'kind': {'peptide_bond'}}\n", - "A:SER:84 A:ASP:85 {'kind': {'peptide_bond'}}\n", - "A:ASP:85 A:LEU:86 {'kind': {'peptide_bond'}}\n", - "A:ASP:85 A:LYS:139 {'kind': {'hbond', 'ionic'}}\n", - "A:ASP:85 A:HIS:89 {'kind': {'ionic'}}\n", - "A:LEU:86 A:HIS:87 {'kind': {'peptide_bond'}}\n", - "A:HIS:87 A:ALA:88 {'kind': {'peptide_bond'}}\n", - "A:HIS:87 A:PHE:98 {'kind': {'aromatic'}}\n", - "A:HIS:87 A:TYR:140 {'kind': {'aromatic'}}\n", - "A:ALA:88 A:HIS:89 {'kind': {'peptide_bond'}}\n", - "A:HIS:89 A:LYS:90 {'kind': {'peptide_bond'}}\n", - "A:LYS:90 A:LEU:91 {'kind': {'peptide_bond'}}\n", - "A:LEU:91 A:ARG:92 {'kind': {'peptide_bond'}}\n", - "A:ARG:92 A:VAL:93 {'kind': {'peptide_bond'}}\n", - "A:ARG:92 D:GLU:43 {'kind': {'ionic'}}\n", - "A:VAL:93 A:ASP:94 {'kind': {'peptide_bond'}}\n", - "A:ASP:94 A:PRO:95 {'kind': {'peptide_bond'}}\n", - "A:PRO:95 A:VAL:96 {'kind': {'peptide_bond'}}\n", - "A:VAL:96 A:ASN:97 {'kind': {'peptide_bond'}}\n", - "A:ASN:97 A:PHE:98 {'kind': {'peptide_bond'}}\n", - "A:PHE:98 A:LYS:99 {'kind': {'peptide_bond'}}\n", - "A:PHE:98 A:TYR:140 {'kind': {'aromatic'}}\n", - "A:LYS:99 A:LEU:100 {'kind': {'peptide_bond'}}\n", - "A:LEU:100 A:LEU:101 {'kind': {'peptide_bond'}}\n", - "A:LEU:101 A:SER:102 {'kind': {'peptide_bond'}}\n", - "A:SER:102 A:HIS:103 {'kind': {'peptide_bond'}}\n", - "A:SER:102 A:SER:133 {'kind': {'hbond'}}\n", - "A:HIS:103 A:CYS:104 {'kind': {'peptide_bond'}}\n", - "A:CYS:104 A:LEU:105 {'kind': {'peptide_bond'}}\n", - "A:LEU:105 A:LEU:106 {'kind': {'peptide_bond'}}\n", - "A:LEU:106 A:VAL:107 {'kind': {'peptide_bond'}}\n", - "A:VAL:107 A:THR:108 {'kind': {'peptide_bond'}}\n", - "A:THR:108 A:LEU:109 {'kind': {'peptide_bond'}}\n", - "A:LEU:109 A:ALA:110 {'kind': {'peptide_bond'}}\n", - "A:ALA:110 A:ALA:111 {'kind': {'peptide_bond'}}\n", - "A:ALA:111 A:HIS:112 {'kind': {'peptide_bond'}}\n", - "A:HIS:112 A:LEU:113 {'kind': {'peptide_bond'}}\n", - "A:LEU:113 A:PRO:114 {'kind': {'peptide_bond'}}\n", - "A:PRO:114 A:ALA:115 {'kind': {'peptide_bond'}}\n", - "A:ALA:115 A:GLU:116 {'kind': {'peptide_bond'}}\n", - "A:GLU:116 A:PHE:117 {'kind': {'peptide_bond'}}\n", - "A:PHE:117 A:THR:118 {'kind': {'peptide_bond'}}\n", - "A:PHE:117 B:HIS:116 {'kind': {'aromatic'}}\n", - "A:THR:118 A:PRO:119 {'kind': {'peptide_bond'}}\n", - "A:PRO:119 A:ALA:120 {'kind': {'peptide_bond'}}\n", - "A:ALA:120 A:VAL:121 {'kind': {'peptide_bond'}}\n", - "A:VAL:121 A:HIS:122 {'kind': {'peptide_bond'}}\n", - "A:HIS:122 A:ALA:123 {'kind': {'peptide_bond'}}\n", - "A:HIS:122 A:ASP:126 {'kind': {'ionic'}}\n", - "A:ALA:123 A:SER:124 {'kind': {'peptide_bond'}}\n", - "A:SER:124 A:LEU:125 {'kind': {'peptide_bond'}}\n", - "A:LEU:125 A:ASP:126 {'kind': {'peptide_bond'}}\n", - "A:ASP:126 A:LYS:127 {'kind': {'peptide_bond', 'ionic'}}\n", - "A:ASP:126 B:TYR:35 {'kind': {'hbond'}}\n", - "A:ASP:126 C:ARG:141 {'kind': {'ionic'}}\n", - "A:LYS:127 A:PHE:128 {'kind': {'peptide_bond'}}\n", - "A:PHE:128 A:LEU:129 {'kind': {'peptide_bond'}}\n", - "A:LEU:129 A:ALA:130 {'kind': {'peptide_bond'}}\n", - "A:ALA:130 A:SER:131 {'kind': {'peptide_bond'}}\n", - "A:SER:131 A:VAL:132 {'kind': {'peptide_bond'}}\n", - "A:VAL:132 A:SER:133 {'kind': {'peptide_bond'}}\n", - "A:SER:133 A:THR:134 {'kind': {'peptide_bond'}}\n", - "A:THR:134 A:VAL:135 {'kind': {'peptide_bond'}}\n", - "A:VAL:135 A:LEU:136 {'kind': {'peptide_bond'}}\n", - "A:LEU:136 A:THR:137 {'kind': {'peptide_bond'}}\n", - "A:THR:137 A:SER:138 {'kind': {'peptide_bond'}}\n", - "A:SER:138 A:LYS:139 {'kind': {'peptide_bond'}}\n", - "A:LYS:139 A:TYR:140 {'kind': {'peptide_bond'}}\n", - "A:TYR:140 A:ARG:141 {'kind': {'peptide_bond'}}\n", - "A:ARG:141 C:ASP:126 {'kind': {'ionic'}}\n", - "A:ARG:141 C:ASP:6 {'kind': {'ionic'}}\n", - "B:VAL:1 B:HIS:2 {'kind': {'peptide_bond'}}\n", - "B:HIS:2 B:LEU:3 {'kind': {'peptide_bond'}}\n", - "B:HIS:2 B:GLU:7 {'kind': {'ionic'}}\n", - "B:LEU:3 B:THR:4 {'kind': {'peptide_bond'}}\n", - "B:THR:4 B:PRO:5 {'kind': {'peptide_bond'}}\n", - "B:PRO:5 B:GLU:6 {'kind': {'peptide_bond'}}\n", - "B:GLU:6 B:GLU:7 {'kind': {'peptide_bond'}}\n", - "B:GLU:7 B:LYS:8 {'kind': {'peptide_bond', 'ionic'}}\n", - "B:GLU:7 B:LYS:132 {'kind': {'ionic'}}\n", - "B:LYS:8 B:SER:9 {'kind': {'peptide_bond'}}\n", - "B:SER:9 B:ALA:10 {'kind': {'peptide_bond'}}\n", - "B:ALA:10 B:VAL:11 {'kind': {'peptide_bond'}}\n", - "B:VAL:11 B:THR:12 {'kind': {'peptide_bond'}}\n", - "B:THR:12 B:ALA:13 {'kind': {'peptide_bond'}}\n", - "B:ALA:13 B:LEU:14 {'kind': {'peptide_bond'}}\n", - "B:LEU:14 B:TRP:15 {'kind': {'peptide_bond'}}\n", - "B:TRP:15 B:GLY:16 {'kind': {'peptide_bond'}}\n", - "B:GLY:16 B:LYS:17 {'kind': {'peptide_bond'}}\n", - "B:LYS:17 B:VAL:18 {'kind': {'peptide_bond'}}\n", - "B:LYS:17 B:GLU:121 {'kind': {'ionic'}}\n", - "B:VAL:18 B:ASN:19 {'kind': {'peptide_bond'}}\n", - "B:ASN:19 B:VAL:20 {'kind': {'peptide_bond'}}\n", - "B:VAL:20 B:ASP:21 {'kind': {'peptide_bond'}}\n", - "B:ASP:21 B:GLU:22 {'kind': {'peptide_bond'}}\n", - "B:ASP:21 B:LYS:65 {'kind': {'ionic'}}\n", - "B:GLU:22 B:VAL:23 {'kind': {'peptide_bond'}}\n", - "B:GLU:22 B:HIS:117 {'kind': {'ionic'}}\n", - "B:VAL:23 B:GLY:24 {'kind': {'peptide_bond'}}\n", - "B:GLY:24 B:GLY:25 {'kind': {'peptide_bond'}}\n", - "B:GLY:25 B:GLU:26 {'kind': {'peptide_bond'}}\n", - "B:GLU:26 B:ALA:27 {'kind': {'peptide_bond'}}\n", - "B:GLU:26 B:ARG:30 {'kind': {'ionic'}}\n", - "B:GLU:26 B:HIS:117 {'kind': {'ionic'}}\n", - "B:GLU:26 B:HIS:116 {'kind': {'ionic'}}\n", - "B:ALA:27 B:LEU:28 {'kind': {'peptide_bond'}}\n", - "B:LEU:28 B:GLY:29 {'kind': {'peptide_bond'}}\n", - "B:GLY:29 B:ARG:30 {'kind': {'peptide_bond'}}\n", - "B:ARG:30 B:LEU:31 {'kind': {'peptide_bond'}}\n", - "B:LEU:31 B:LEU:32 {'kind': {'peptide_bond'}}\n", - "B:LEU:32 B:VAL:33 {'kind': {'peptide_bond'}}\n", - "B:VAL:33 B:VAL:34 {'kind': {'peptide_bond'}}\n", - "B:VAL:34 B:TYR:35 {'kind': {'peptide_bond'}}\n", - "B:TYR:35 B:PRO:36 {'kind': {'peptide_bond'}}\n", - "B:PRO:36 B:TRP:37 {'kind': {'peptide_bond'}}\n", - "B:TRP:37 B:THR:38 {'kind': {'peptide_bond'}}\n", - "B:THR:38 B:GLN:39 {'kind': {'peptide_bond'}}\n", - "B:GLN:39 B:ARG:40 {'kind': {'peptide_bond'}}\n", - "B:ARG:40 B:PHE:41 {'kind': {'peptide_bond'}}\n", - "B:PHE:41 B:PHE:42 {'kind': {'peptide_bond', 'aromatic'}}\n", - "B:PHE:42 B:GLU:43 {'kind': {'peptide_bond'}}\n", - "B:PHE:42 B:HIS:63 {'kind': {'aromatic'}}\n", - "B:PHE:42 B:PHE:45 {'kind': {'aromatic'}}\n", - "B:GLU:43 B:SER:44 {'kind': {'peptide_bond'}}\n", - "B:GLU:43 C:ARG:92 {'kind': {'ionic'}}\n", - "B:SER:44 B:PHE:45 {'kind': {'peptide_bond'}}\n", - "B:PHE:45 B:GLY:46 {'kind': {'peptide_bond'}}\n", - "B:PHE:45 B:HIS:63 {'kind': {'aromatic'}}\n", - "B:GLY:46 B:ASP:47 {'kind': {'peptide_bond'}}\n", - "B:ASP:47 B:LEU:48 {'kind': {'peptide_bond'}}\n", - "B:ASP:47 B:SER:49 {'kind': {'hbond'}}\n", - "B:LEU:48 B:SER:49 {'kind': {'peptide_bond'}}\n", - "B:SER:49 B:THR:50 {'kind': {'peptide_bond'}}\n", - "B:THR:50 B:PRO:51 {'kind': {'peptide_bond'}}\n", - "B:PRO:51 B:ASP:52 {'kind': {'peptide_bond'}}\n", - "B:ASP:52 B:ALA:53 {'kind': {'peptide_bond'}}\n", - "B:ALA:53 B:VAL:54 {'kind': {'peptide_bond'}}\n", - "B:VAL:54 B:MET:55 {'kind': {'peptide_bond'}}\n", - "B:MET:55 B:GLY:56 {'kind': {'peptide_bond'}}\n", - "B:GLY:56 B:ASN:57 {'kind': {'peptide_bond'}}\n", - "B:ASN:57 B:PRO:58 {'kind': {'peptide_bond'}}\n", - "B:PRO:58 B:LYS:59 {'kind': {'peptide_bond'}}\n", - "B:LYS:59 B:VAL:60 {'kind': {'peptide_bond'}}\n", - "B:VAL:60 B:LYS:61 {'kind': {'peptide_bond'}}\n", - "B:LYS:61 B:ALA:62 {'kind': {'peptide_bond'}}\n", - "B:ALA:62 B:HIS:63 {'kind': {'peptide_bond'}}\n", - "B:HIS:63 B:GLY:64 {'kind': {'peptide_bond'}}\n", - "B:GLY:64 B:LYS:65 {'kind': {'peptide_bond'}}\n", - "B:LYS:65 B:LYS:66 {'kind': {'peptide_bond'}}\n", - "B:LYS:66 B:VAL:67 {'kind': {'peptide_bond'}}\n", - "B:VAL:67 B:LEU:68 {'kind': {'peptide_bond'}}\n", - "B:LEU:68 B:GLY:69 {'kind': {'peptide_bond'}}\n", - "B:GLY:69 B:ALA:70 {'kind': {'peptide_bond'}}\n", - "B:ALA:70 B:PHE:71 {'kind': {'peptide_bond'}}\n", - "B:PHE:71 B:SER:72 {'kind': {'peptide_bond'}}\n", - "B:SER:72 B:ASP:73 {'kind': {'peptide_bond'}}\n", - "B:ASP:73 B:GLY:74 {'kind': {'peptide_bond'}}\n", - "B:ASP:73 B:HIS:77 {'kind': {'ionic'}}\n", - "B:GLY:74 B:LEU:75 {'kind': {'peptide_bond'}}\n", - "B:LEU:75 B:ALA:76 {'kind': {'peptide_bond'}}\n", - "B:ALA:76 B:HIS:77 {'kind': {'peptide_bond'}}\n", - "B:HIS:77 B:LEU:78 {'kind': {'peptide_bond'}}\n", - "B:LEU:78 B:ASP:79 {'kind': {'peptide_bond'}}\n", - "B:ASP:79 B:ASN:80 {'kind': {'peptide_bond'}}\n", - "B:ASN:80 B:LEU:81 {'kind': {'peptide_bond'}}\n", - "B:LEU:81 B:LYS:82 {'kind': {'peptide_bond'}}\n", - "B:LYS:82 B:GLY:83 {'kind': {'peptide_bond'}}\n", - "B:GLY:83 B:THR:84 {'kind': {'peptide_bond'}}\n", - "B:THR:84 B:PHE:85 {'kind': {'peptide_bond'}}\n", - "B:PHE:85 B:ALA:86 {'kind': {'peptide_bond'}}\n", - "B:ALA:86 B:THR:87 {'kind': {'peptide_bond'}}\n", - "B:THR:87 B:LEU:88 {'kind': {'peptide_bond'}}\n", - "B:LEU:88 B:SER:89 {'kind': {'peptide_bond'}}\n", - "B:SER:89 B:GLU:90 {'kind': {'peptide_bond'}}\n", - "B:GLU:90 B:LEU:91 {'kind': {'peptide_bond'}}\n", - "B:GLU:90 B:LYS:144 {'kind': {'ionic'}}\n", - "B:LEU:91 B:HIS:92 {'kind': {'peptide_bond'}}\n", - "B:HIS:92 B:CYS:93 {'kind': {'peptide_bond'}}\n", - "B:HIS:92 B:PHE:103 {'kind': {'aromatic'}}\n", - "B:HIS:92 B:TYR:145 {'kind': {'aromatic'}}\n", - "B:CYS:93 B:ASP:94 {'kind': {'peptide_bond'}}\n", - "B:ASP:94 B:LYS:95 {'kind': {'peptide_bond', 'ionic'}}\n", - "B:ASP:94 B:HIS:146 {'kind': {'ionic'}}\n", - "B:ASP:94 B:HIS:97 {'kind': {'ionic'}}\n", - "B:LYS:95 B:LEU:96 {'kind': {'peptide_bond'}}\n", - "B:LEU:96 B:HIS:97 {'kind': {'peptide_bond'}}\n", - "B:HIS:97 B:VAL:98 {'kind': {'peptide_bond'}}\n", - "B:VAL:98 B:ASP:99 {'kind': {'peptide_bond'}}\n", - "B:ASP:99 B:PRO:100 {'kind': {'peptide_bond'}}\n", - "B:ASP:99 C:TYR:42 {'kind': {'hbond'}}\n", - "B:PRO:100 B:GLU:101 {'kind': {'peptide_bond'}}\n", - "B:GLU:101 B:ASN:102 {'kind': {'peptide_bond'}}\n", - "B:GLU:101 B:ARG:104 {'kind': {'ionic'}}\n", - "B:ASN:102 B:PHE:103 {'kind': {'peptide_bond'}}\n", - "B:PHE:103 B:ARG:104 {'kind': {'peptide_bond'}}\n", - "B:PHE:103 B:TYR:145 {'kind': {'aromatic'}}\n", - "B:ARG:104 B:LEU:105 {'kind': {'peptide_bond'}}\n", - "B:LEU:105 B:LEU:106 {'kind': {'peptide_bond'}}\n", - "B:LEU:106 B:GLY:107 {'kind': {'peptide_bond'}}\n", - "B:GLY:107 B:ASN:108 {'kind': {'peptide_bond'}}\n", - "B:ASN:108 B:VAL:109 {'kind': {'peptide_bond'}}\n", - "B:VAL:109 B:LEU:110 {'kind': {'peptide_bond'}}\n", - "B:LEU:110 B:VAL:111 {'kind': {'peptide_bond'}}\n", - "B:VAL:111 B:CYS:112 {'kind': {'peptide_bond'}}\n", - "B:CYS:112 B:VAL:113 {'kind': {'peptide_bond'}}\n", - "B:VAL:113 B:LEU:114 {'kind': {'peptide_bond'}}\n", - "B:LEU:114 B:ALA:115 {'kind': {'peptide_bond'}}\n", - "B:ALA:115 B:HIS:116 {'kind': {'peptide_bond'}}\n", - "B:HIS:116 B:HIS:117 {'kind': {'peptide_bond', 'aromatic'}}\n", - "B:HIS:117 B:PHE:118 {'kind': {'peptide_bond', 'aromatic'}}\n", - "B:PHE:118 B:GLY:119 {'kind': {'peptide_bond'}}\n", - "B:GLY:119 B:LYS:120 {'kind': {'peptide_bond'}}\n", - "B:LYS:120 B:GLU:121 {'kind': {'peptide_bond', 'ionic'}}\n", - "B:GLU:121 B:PHE:122 {'kind': {'peptide_bond'}}\n", - "B:PHE:122 B:THR:123 {'kind': {'peptide_bond'}}\n", - "B:PHE:122 B:TYR:130 {'kind': {'aromatic'}}\n", - "B:THR:123 B:PRO:124 {'kind': {'peptide_bond'}}\n", - "B:PRO:124 B:PRO:125 {'kind': {'peptide_bond'}}\n", - "B:PRO:125 B:VAL:126 {'kind': {'peptide_bond'}}\n", - "B:VAL:126 B:GLN:127 {'kind': {'peptide_bond'}}\n", - "B:GLN:127 B:ALA:128 {'kind': {'peptide_bond'}}\n", - "B:ALA:128 B:ALA:129 {'kind': {'peptide_bond'}}\n", - "B:ALA:129 B:TYR:130 {'kind': {'peptide_bond'}}\n", - "B:TYR:130 B:GLN:131 {'kind': {'peptide_bond'}}\n", - "B:GLN:131 B:LYS:132 {'kind': {'peptide_bond'}}\n", - "B:LYS:132 B:VAL:133 {'kind': {'peptide_bond'}}\n", - "B:VAL:133 B:VAL:134 {'kind': {'peptide_bond'}}\n", - "B:VAL:134 B:ALA:135 {'kind': {'peptide_bond'}}\n", - "B:ALA:135 B:GLY:136 {'kind': {'peptide_bond'}}\n", - "B:GLY:136 B:VAL:137 {'kind': {'peptide_bond'}}\n", - "B:VAL:137 B:ALA:138 {'kind': {'peptide_bond'}}\n", - "B:ALA:138 B:ASN:139 {'kind': {'peptide_bond'}}\n", - "B:ASN:139 B:ALA:140 {'kind': {'peptide_bond'}}\n", - "B:ALA:140 B:LEU:141 {'kind': {'peptide_bond'}}\n", - "B:LEU:141 B:ALA:142 {'kind': {'peptide_bond'}}\n", - "B:ALA:142 B:HIS:143 {'kind': {'peptide_bond'}}\n", - "B:HIS:143 B:LYS:144 {'kind': {'peptide_bond'}}\n", - "B:LYS:144 B:TYR:145 {'kind': {'peptide_bond'}}\n", - "B:TYR:145 B:HIS:146 {'kind': {'peptide_bond'}}\n", - "C:VAL:1 C:LEU:2 {'kind': {'peptide_bond'}}\n", - "C:LEU:2 C:SER:3 {'kind': {'peptide_bond'}}\n", - "C:SER:3 C:PRO:4 {'kind': {'peptide_bond'}}\n", - "C:SER:3 C:ASP:6 {'kind': {'hbond'}}\n", - "C:PRO:4 C:ALA:5 {'kind': {'peptide_bond'}}\n", - "C:ALA:5 C:ASP:6 {'kind': {'peptide_bond'}}\n", - "C:ASP:6 C:LYS:7 {'kind': {'peptide_bond', 'ionic'}}\n", - "C:ASP:6 C:SER:124 {'kind': {'hbond'}}\n", - "C:ASP:6 C:LYS:127 {'kind': {'hbond', 'ionic'}}\n", - "C:LYS:7 C:THR:8 {'kind': {'peptide_bond'}}\n", - "C:LYS:7 C:ASP:74 {'kind': {'hbond', 'ionic'}}\n", - "C:THR:8 C:ASN:9 {'kind': {'peptide_bond'}}\n", - "C:ASN:9 C:VAL:10 {'kind': {'peptide_bond'}}\n", - "C:VAL:10 C:LYS:11 {'kind': {'peptide_bond'}}\n", - "C:LYS:11 C:ALA:12 {'kind': {'peptide_bond'}}\n", - "C:LYS:11 C:ASP:74 {'kind': {'ionic'}}\n", - "C:ALA:12 C:ALA:13 {'kind': {'peptide_bond'}}\n", - "C:ALA:13 C:TRP:14 {'kind': {'peptide_bond'}}\n", - "C:TRP:14 C:GLY:15 {'kind': {'peptide_bond'}}\n", - "C:GLY:15 C:LYS:16 {'kind': {'peptide_bond'}}\n", - "C:LYS:16 C:VAL:17 {'kind': {'peptide_bond'}}\n", - "C:LYS:16 C:GLU:116 {'kind': {'ionic'}}\n", - "C:VAL:17 C:GLY:18 {'kind': {'peptide_bond'}}\n", - "C:GLY:18 C:ALA:19 {'kind': {'peptide_bond'}}\n", - "C:ALA:19 C:HIS:20 {'kind': {'peptide_bond'}}\n", - "C:HIS:20 C:ALA:21 {'kind': {'peptide_bond'}}\n", - "C:HIS:20 C:GLU:23 {'kind': {'ionic'}}\n", - "C:HIS:20 C:HIS:112 {'kind': {'aromatic'}}\n", - "C:HIS:20 C:TYR:24 {'kind': {'aromatic'}}\n", - "C:ALA:21 C:GLY:22 {'kind': {'peptide_bond'}}\n", - "C:GLY:22 C:GLU:23 {'kind': {'peptide_bond'}}\n", - "C:GLU:23 C:TYR:24 {'kind': {'peptide_bond'}}\n", - "C:GLU:23 C:HIS:112 {'kind': {'ionic'}}\n", - "C:TYR:24 C:GLY:25 {'kind': {'peptide_bond'}}\n", - "C:GLY:25 C:ALA:26 {'kind': {'peptide_bond'}}\n", - "C:ALA:26 C:GLU:27 {'kind': {'peptide_bond'}}\n", - "C:GLU:27 C:ALA:28 {'kind': {'peptide_bond'}}\n", - "C:GLU:27 C:ARG:31 {'kind': {'ionic'}}\n", - "C:GLU:27 C:HIS:112 {'kind': {'ionic'}}\n", - "C:ALA:28 C:LEU:29 {'kind': {'peptide_bond'}}\n", - "C:LEU:29 C:GLU:30 {'kind': {'peptide_bond'}}\n", - "C:GLU:30 C:ARG:31 {'kind': {'peptide_bond', 'ionic'}}\n", - "C:GLU:30 C:HIS:50 {'kind': {'ionic'}}\n", - "C:ARG:31 C:MET:32 {'kind': {'peptide_bond'}}\n", - "C:MET:32 C:PHE:33 {'kind': {'peptide_bond'}}\n", - "C:PHE:33 C:LEU:34 {'kind': {'peptide_bond'}}\n", - "C:PHE:33 C:PHE:43 {'kind': {'aromatic'}}\n", - "C:LEU:34 C:SER:35 {'kind': {'peptide_bond'}}\n", - "C:SER:35 C:PHE:36 {'kind': {'peptide_bond'}}\n", - "C:PHE:36 C:PRO:37 {'kind': {'peptide_bond'}}\n", - "C:PHE:36 C:HIS:103 {'kind': {'aromatic'}}\n", - "C:PRO:37 C:THR:38 {'kind': {'peptide_bond'}}\n", - "C:THR:38 C:THR:39 {'kind': {'peptide_bond'}}\n", - "C:THR:39 C:LYS:40 {'kind': {'peptide_bond'}}\n", - "C:LYS:40 C:THR:41 {'kind': {'peptide_bond'}}\n", - "C:THR:41 C:TYR:42 {'kind': {'peptide_bond'}}\n", - "C:TYR:42 C:PHE:43 {'kind': {'peptide_bond'}}\n", - "C:PHE:43 C:PRO:44 {'kind': {'peptide_bond'}}\n", - "C:PHE:43 C:HIS:58 {'kind': {'aromatic'}}\n", - "C:PHE:43 C:PHE:46 {'kind': {'aromatic'}}\n", - "C:PRO:44 C:HIS:45 {'kind': {'peptide_bond'}}\n", - "C:HIS:45 C:PHE:46 {'kind': {'peptide_bond', 'aromatic'}}\n", - "C:PHE:46 C:ASP:47 {'kind': {'peptide_bond'}}\n", - "C:PHE:46 C:HIS:58 {'kind': {'aromatic'}}\n", - "C:ASP:47 C:LEU:48 {'kind': {'peptide_bond'}}\n", - "C:ASP:47 C:SER:49 {'kind': {'hbond'}}\n", - "C:LEU:48 C:SER:49 {'kind': {'peptide_bond'}}\n", - "C:SER:49 C:HIS:50 {'kind': {'peptide_bond'}}\n", - "C:HIS:50 C:GLY:51 {'kind': {'peptide_bond'}}\n", - "C:GLY:51 C:SER:52 {'kind': {'peptide_bond'}}\n", - "C:SER:52 C:ALA:53 {'kind': {'peptide_bond'}}\n", - "C:ALA:53 C:GLN:54 {'kind': {'peptide_bond'}}\n", - "C:GLN:54 C:VAL:55 {'kind': {'peptide_bond'}}\n", - "C:VAL:55 C:LYS:56 {'kind': {'peptide_bond'}}\n", - "C:LYS:56 C:GLY:57 {'kind': {'peptide_bond'}}\n", - "C:GLY:57 C:HIS:58 {'kind': {'peptide_bond'}}\n", - "C:HIS:58 C:GLY:59 {'kind': {'peptide_bond'}}\n", - "C:GLY:59 C:LYS:60 {'kind': {'peptide_bond'}}\n", - "C:LYS:60 C:LYS:61 {'kind': {'peptide_bond'}}\n", - "C:LYS:60 C:ASP:64 {'kind': {'hbond', 'ionic'}}\n", - "C:LYS:61 C:VAL:62 {'kind': {'peptide_bond'}}\n", - "C:LYS:61 C:ASP:64 {'kind': {'ionic'}}\n", - "C:VAL:62 C:ALA:63 {'kind': {'peptide_bond'}}\n", - "C:ALA:63 C:ASP:64 {'kind': {'peptide_bond'}}\n", - "C:ASP:64 C:ALA:65 {'kind': {'peptide_bond'}}\n", - "C:ALA:65 C:LEU:66 {'kind': {'peptide_bond'}}\n", - "C:LEU:66 C:THR:67 {'kind': {'peptide_bond'}}\n", - "C:THR:67 C:ASN:68 {'kind': {'peptide_bond'}}\n", - "C:ASN:68 C:ALA:69 {'kind': {'peptide_bond'}}\n", - "C:ALA:69 C:VAL:70 {'kind': {'peptide_bond'}}\n", - "C:VAL:70 C:ALA:71 {'kind': {'peptide_bond'}}\n", - "C:ALA:71 C:HIS:72 {'kind': {'peptide_bond'}}\n", - "C:HIS:72 C:VAL:73 {'kind': {'peptide_bond'}}\n", - "C:HIS:72 C:ASP:75 {'kind': {'ionic'}}\n", - "C:VAL:73 C:ASP:74 {'kind': {'peptide_bond'}}\n", - "C:ASP:74 C:ASP:75 {'kind': {'peptide_bond'}}\n", - "C:ASP:75 C:MET:76 {'kind': {'peptide_bond'}}\n", - "C:MET:76 C:PRO:77 {'kind': {'peptide_bond'}}\n", - "C:PRO:77 C:ASN:78 {'kind': {'peptide_bond'}}\n", - "C:ASN:78 C:ALA:79 {'kind': {'peptide_bond'}}\n", - "C:ALA:79 C:LEU:80 {'kind': {'peptide_bond'}}\n", - "C:LEU:80 C:SER:81 {'kind': {'peptide_bond'}}\n", - "C:SER:81 C:ALA:82 {'kind': {'peptide_bond'}}\n", - "C:SER:81 C:LYS:139 {'kind': {'hbond'}}\n", - "C:ALA:82 C:LEU:83 {'kind': {'peptide_bond'}}\n", - "C:LEU:83 C:SER:84 {'kind': {'peptide_bond'}}\n", - "C:SER:84 C:ASP:85 {'kind': {'peptide_bond'}}\n", - "C:ASP:85 C:LEU:86 {'kind': {'peptide_bond'}}\n", - "C:ASP:85 C:LYS:139 {'kind': {'hbond', 'ionic'}}\n", - "C:ASP:85 C:HIS:89 {'kind': {'ionic'}}\n", - "C:LEU:86 C:HIS:87 {'kind': {'peptide_bond'}}\n", - "C:HIS:87 C:ALA:88 {'kind': {'peptide_bond'}}\n", - "C:HIS:87 C:PHE:98 {'kind': {'aromatic'}}\n", - "C:HIS:87 C:TYR:140 {'kind': {'aromatic'}}\n", - "C:ALA:88 C:HIS:89 {'kind': {'peptide_bond'}}\n", - "C:HIS:89 C:LYS:90 {'kind': {'peptide_bond'}}\n", - "C:LYS:90 C:LEU:91 {'kind': {'peptide_bond'}}\n", - "C:LEU:91 C:ARG:92 {'kind': {'peptide_bond'}}\n", - "C:ARG:92 C:VAL:93 {'kind': {'peptide_bond'}}\n", - "C:VAL:93 C:ASP:94 {'kind': {'peptide_bond'}}\n", - "C:ASP:94 C:PRO:95 {'kind': {'peptide_bond'}}\n", - "C:PRO:95 C:VAL:96 {'kind': {'peptide_bond'}}\n", - "C:VAL:96 C:ASN:97 {'kind': {'peptide_bond'}}\n", - "C:ASN:97 C:PHE:98 {'kind': {'peptide_bond'}}\n", - "C:PHE:98 C:LYS:99 {'kind': {'peptide_bond'}}\n", - "C:PHE:98 C:TYR:140 {'kind': {'aromatic'}}\n", - "C:LYS:99 C:LEU:100 {'kind': {'peptide_bond'}}\n", - "C:LEU:100 C:LEU:101 {'kind': {'peptide_bond'}}\n", - "C:LEU:101 C:SER:102 {'kind': {'peptide_bond'}}\n", - "C:SER:102 C:HIS:103 {'kind': {'peptide_bond'}}\n", - "C:HIS:103 C:CYS:104 {'kind': {'peptide_bond'}}\n", - "C:CYS:104 C:LEU:105 {'kind': {'peptide_bond'}}\n", - "C:LEU:105 C:LEU:106 {'kind': {'peptide_bond'}}\n", - "C:LEU:106 C:VAL:107 {'kind': {'peptide_bond'}}\n", - "C:VAL:107 C:THR:108 {'kind': {'peptide_bond'}}\n", - "C:THR:108 C:LEU:109 {'kind': {'peptide_bond'}}\n", - "C:LEU:109 C:ALA:110 {'kind': {'peptide_bond'}}\n", - "C:ALA:110 C:ALA:111 {'kind': {'peptide_bond'}}\n", - "C:ALA:111 C:HIS:112 {'kind': {'peptide_bond'}}\n", - "C:HIS:112 C:LEU:113 {'kind': {'peptide_bond'}}\n", - "C:LEU:113 C:PRO:114 {'kind': {'peptide_bond'}}\n", - "C:PRO:114 C:ALA:115 {'kind': {'peptide_bond'}}\n", - "C:ALA:115 C:GLU:116 {'kind': {'peptide_bond'}}\n", - "C:GLU:116 C:PHE:117 {'kind': {'peptide_bond'}}\n", - "C:PHE:117 C:THR:118 {'kind': {'peptide_bond'}}\n", - "C:PHE:117 D:HIS:116 {'kind': {'aromatic'}}\n", - "C:THR:118 C:PRO:119 {'kind': {'peptide_bond'}}\n", - "C:PRO:119 C:ALA:120 {'kind': {'peptide_bond'}}\n", - "C:ALA:120 C:VAL:121 {'kind': {'peptide_bond'}}\n", - "C:VAL:121 C:HIS:122 {'kind': {'peptide_bond'}}\n", - "C:HIS:122 C:ALA:123 {'kind': {'peptide_bond'}}\n", - "C:HIS:122 C:ASP:126 {'kind': {'ionic'}}\n", - "C:ALA:123 C:SER:124 {'kind': {'peptide_bond'}}\n", - "C:SER:124 C:LEU:125 {'kind': {'peptide_bond'}}\n", - "C:LEU:125 C:ASP:126 {'kind': {'peptide_bond'}}\n", - "C:ASP:126 C:LYS:127 {'kind': {'peptide_bond', 'ionic'}}\n", - "C:LYS:127 C:PHE:128 {'kind': {'peptide_bond'}}\n", - "C:PHE:128 C:LEU:129 {'kind': {'peptide_bond'}}\n", - "C:LEU:129 C:ALA:130 {'kind': {'peptide_bond'}}\n", - "C:ALA:130 C:SER:131 {'kind': {'peptide_bond'}}\n", - "C:SER:131 C:VAL:132 {'kind': {'peptide_bond'}}\n", - "C:VAL:132 C:SER:133 {'kind': {'peptide_bond'}}\n", - "C:SER:133 C:THR:134 {'kind': {'peptide_bond'}}\n", - "C:THR:134 C:VAL:135 {'kind': {'peptide_bond'}}\n", - "C:VAL:135 C:LEU:136 {'kind': {'peptide_bond'}}\n", - "C:LEU:136 C:THR:137 {'kind': {'peptide_bond'}}\n", - "C:THR:137 C:SER:138 {'kind': {'peptide_bond'}}\n", - "C:SER:138 C:LYS:139 {'kind': {'peptide_bond'}}\n", - "C:LYS:139 C:TYR:140 {'kind': {'peptide_bond'}}\n", - "C:TYR:140 C:ARG:141 {'kind': {'peptide_bond'}}\n", - "D:VAL:1 D:HIS:2 {'kind': {'peptide_bond'}}\n", - "D:HIS:2 D:LEU:3 {'kind': {'peptide_bond'}}\n", - "D:HIS:2 D:GLU:7 {'kind': {'ionic'}}\n", - "D:LEU:3 D:THR:4 {'kind': {'peptide_bond'}}\n", - "D:THR:4 D:PRO:5 {'kind': {'peptide_bond'}}\n", - "D:PRO:5 D:GLU:6 {'kind': {'peptide_bond'}}\n", - "D:GLU:6 D:GLU:7 {'kind': {'peptide_bond'}}\n", - "D:GLU:7 D:LYS:8 {'kind': {'peptide_bond', 'ionic'}}\n", - "D:GLU:7 D:LYS:132 {'kind': {'ionic'}}\n", - "D:LYS:8 D:SER:9 {'kind': {'peptide_bond'}}\n", - "D:LYS:8 D:ASP:79 {'kind': {'ionic'}}\n", - "D:SER:9 D:ALA:10 {'kind': {'peptide_bond'}}\n", - "D:ALA:10 D:VAL:11 {'kind': {'peptide_bond'}}\n", - "D:VAL:11 D:THR:12 {'kind': {'peptide_bond'}}\n", - "D:THR:12 D:ALA:13 {'kind': {'peptide_bond'}}\n", - "D:ALA:13 D:LEU:14 {'kind': {'peptide_bond'}}\n", - "D:LEU:14 D:TRP:15 {'kind': {'peptide_bond'}}\n", - "D:TRP:15 D:GLY:16 {'kind': {'peptide_bond'}}\n", - "D:GLY:16 D:LYS:17 {'kind': {'peptide_bond'}}\n", - "D:LYS:17 D:VAL:18 {'kind': {'peptide_bond'}}\n", - "D:LYS:17 D:GLU:121 {'kind': {'ionic'}}\n", - "D:VAL:18 D:ASN:19 {'kind': {'peptide_bond'}}\n", - "D:ASN:19 D:VAL:20 {'kind': {'peptide_bond'}}\n", - "D:VAL:20 D:ASP:21 {'kind': {'peptide_bond'}}\n", - "D:ASP:21 D:GLU:22 {'kind': {'peptide_bond'}}\n", - "D:ASP:21 D:LYS:65 {'kind': {'hbond', 'ionic'}}\n", - "D:GLU:22 D:VAL:23 {'kind': {'peptide_bond'}}\n", - "D:GLU:22 D:HIS:117 {'kind': {'ionic'}}\n", - "D:VAL:23 D:GLY:24 {'kind': {'peptide_bond'}}\n", - "D:GLY:24 D:GLY:25 {'kind': {'peptide_bond'}}\n", - "D:GLY:25 D:GLU:26 {'kind': {'peptide_bond'}}\n", - "D:GLU:26 D:ALA:27 {'kind': {'peptide_bond'}}\n", - "D:GLU:26 D:HIS:116 {'kind': {'ionic'}}\n", - "D:GLU:26 D:HIS:117 {'kind': {'ionic'}}\n", - "D:GLU:26 D:ARG:30 {'kind': {'ionic'}}\n", - "D:ALA:27 D:LEU:28 {'kind': {'peptide_bond'}}\n", - "D:LEU:28 D:GLY:29 {'kind': {'peptide_bond'}}\n", - "D:GLY:29 D:ARG:30 {'kind': {'peptide_bond'}}\n", - "D:ARG:30 D:LEU:31 {'kind': {'peptide_bond'}}\n", - "D:LEU:31 D:LEU:32 {'kind': {'peptide_bond'}}\n", - "D:LEU:32 D:VAL:33 {'kind': {'peptide_bond'}}\n", - "D:VAL:33 D:VAL:34 {'kind': {'peptide_bond'}}\n", - "D:VAL:34 D:TYR:35 {'kind': {'peptide_bond'}}\n", - "D:TYR:35 D:PRO:36 {'kind': {'peptide_bond'}}\n", - "D:PRO:36 D:TRP:37 {'kind': {'peptide_bond'}}\n", - "D:TRP:37 D:THR:38 {'kind': {'peptide_bond'}}\n", - "D:THR:38 D:GLN:39 {'kind': {'peptide_bond'}}\n", - "D:GLN:39 D:ARG:40 {'kind': {'peptide_bond'}}\n", - "D:ARG:40 D:PHE:41 {'kind': {'peptide_bond'}}\n", - "D:ARG:40 D:GLU:43 {'kind': {'ionic'}}\n", - "D:PHE:41 D:PHE:42 {'kind': {'peptide_bond', 'aromatic'}}\n", - "D:PHE:42 D:GLU:43 {'kind': {'peptide_bond'}}\n", - "D:PHE:42 D:HIS:63 {'kind': {'aromatic'}}\n", - "D:PHE:42 D:PHE:45 {'kind': {'aromatic'}}\n", - "D:GLU:43 D:SER:44 {'kind': {'peptide_bond'}}\n", - "D:SER:44 D:PHE:45 {'kind': {'peptide_bond'}}\n", - "D:PHE:45 D:GLY:46 {'kind': {'peptide_bond'}}\n", - "D:PHE:45 D:HIS:63 {'kind': {'aromatic'}}\n", - "D:GLY:46 D:ASP:47 {'kind': {'peptide_bond'}}\n", - "D:ASP:47 D:LEU:48 {'kind': {'peptide_bond'}}\n", - "D:ASP:47 D:SER:49 {'kind': {'hbond'}}\n", - "D:LEU:48 D:SER:49 {'kind': {'peptide_bond'}}\n", - "D:SER:49 D:THR:50 {'kind': {'peptide_bond'}}\n", - "D:THR:50 D:PRO:51 {'kind': {'peptide_bond'}}\n", - "D:PRO:51 D:ASP:52 {'kind': {'peptide_bond'}}\n", - "D:ASP:52 D:ALA:53 {'kind': {'peptide_bond'}}\n", - "D:ALA:53 D:VAL:54 {'kind': {'peptide_bond'}}\n", - "D:VAL:54 D:MET:55 {'kind': {'peptide_bond'}}\n", - "D:MET:55 D:GLY:56 {'kind': {'peptide_bond'}}\n", - "D:GLY:56 D:ASN:57 {'kind': {'peptide_bond'}}\n", - "D:ASN:57 D:PRO:58 {'kind': {'peptide_bond'}}\n", - "D:PRO:58 D:LYS:59 {'kind': {'peptide_bond'}}\n", - "D:LYS:59 D:VAL:60 {'kind': {'peptide_bond'}}\n", - "D:VAL:60 D:LYS:61 {'kind': {'peptide_bond'}}\n", - "D:LYS:61 D:ALA:62 {'kind': {'peptide_bond'}}\n", - "D:ALA:62 D:HIS:63 {'kind': {'peptide_bond'}}\n", - "D:HIS:63 D:GLY:64 {'kind': {'peptide_bond'}}\n", - "D:GLY:64 D:LYS:65 {'kind': {'peptide_bond'}}\n", - "D:LYS:65 D:LYS:66 {'kind': {'peptide_bond'}}\n", - "D:LYS:66 D:VAL:67 {'kind': {'peptide_bond'}}\n", - "D:VAL:67 D:LEU:68 {'kind': {'peptide_bond'}}\n", - "D:LEU:68 D:GLY:69 {'kind': {'peptide_bond'}}\n", - "D:GLY:69 D:ALA:70 {'kind': {'peptide_bond'}}\n", - "D:ALA:70 D:PHE:71 {'kind': {'peptide_bond'}}\n", - "D:PHE:71 D:SER:72 {'kind': {'peptide_bond'}}\n", - "D:SER:72 D:ASP:73 {'kind': {'peptide_bond'}}\n", - "D:ASP:73 D:GLY:74 {'kind': {'peptide_bond'}}\n", - "D:ASP:73 D:HIS:77 {'kind': {'ionic'}}\n", - "D:GLY:74 D:LEU:75 {'kind': {'peptide_bond'}}\n", - "D:LEU:75 D:ALA:76 {'kind': {'peptide_bond'}}\n", - "D:ALA:76 D:HIS:77 {'kind': {'peptide_bond'}}\n", - "D:HIS:77 D:LEU:78 {'kind': {'peptide_bond'}}\n", - "D:LEU:78 D:ASP:79 {'kind': {'peptide_bond'}}\n", - "D:ASP:79 D:ASN:80 {'kind': {'peptide_bond'}}\n", - "D:ASN:80 D:LEU:81 {'kind': {'peptide_bond'}}\n", - "D:LEU:81 D:LYS:82 {'kind': {'peptide_bond'}}\n", - "D:LYS:82 D:GLY:83 {'kind': {'peptide_bond'}}\n", - "D:GLY:83 D:THR:84 {'kind': {'peptide_bond'}}\n", - "D:THR:84 D:PHE:85 {'kind': {'peptide_bond'}}\n", - "D:PHE:85 D:ALA:86 {'kind': {'peptide_bond'}}\n", - "D:ALA:86 D:THR:87 {'kind': {'peptide_bond'}}\n", - "D:THR:87 D:LEU:88 {'kind': {'peptide_bond'}}\n", - "D:LEU:88 D:SER:89 {'kind': {'peptide_bond'}}\n", - "D:SER:89 D:GLU:90 {'kind': {'peptide_bond'}}\n", - "D:GLU:90 D:LEU:91 {'kind': {'peptide_bond'}}\n", - "D:GLU:90 D:LYS:144 {'kind': {'ionic'}}\n", - "D:LEU:91 D:HIS:92 {'kind': {'peptide_bond'}}\n", - "D:HIS:92 D:CYS:93 {'kind': {'peptide_bond'}}\n", - "D:HIS:92 D:PHE:103 {'kind': {'aromatic'}}\n", - "D:HIS:92 D:TYR:145 {'kind': {'aromatic'}}\n", - "D:CYS:93 D:ASP:94 {'kind': {'peptide_bond'}}\n", - "D:ASP:94 D:LYS:95 {'kind': {'peptide_bond', 'ionic'}}\n", - "D:ASP:94 D:HIS:97 {'kind': {'ionic'}}\n", - "D:ASP:94 D:HIS:146 {'kind': {'ionic'}}\n", - "D:LYS:95 D:LEU:96 {'kind': {'peptide_bond'}}\n", - "D:LEU:96 D:HIS:97 {'kind': {'peptide_bond'}}\n", - "D:HIS:97 D:VAL:98 {'kind': {'peptide_bond'}}\n", - "D:VAL:98 D:ASP:99 {'kind': {'peptide_bond'}}\n", - "D:ASP:99 D:PRO:100 {'kind': {'peptide_bond'}}\n", - "D:PRO:100 D:GLU:101 {'kind': {'peptide_bond'}}\n", - "D:GLU:101 D:ASN:102 {'kind': {'peptide_bond'}}\n", - "D:GLU:101 D:ARG:104 {'kind': {'ionic'}}\n", - "D:ASN:102 D:PHE:103 {'kind': {'peptide_bond'}}\n", - "D:PHE:103 D:ARG:104 {'kind': {'peptide_bond'}}\n", - "D:PHE:103 D:TYR:145 {'kind': {'aromatic'}}\n", - "D:ARG:104 D:LEU:105 {'kind': {'peptide_bond'}}\n", - "D:LEU:105 D:LEU:106 {'kind': {'peptide_bond'}}\n", - "D:LEU:106 D:GLY:107 {'kind': {'peptide_bond'}}\n", - "D:GLY:107 D:ASN:108 {'kind': {'peptide_bond'}}\n", - "D:ASN:108 D:VAL:109 {'kind': {'peptide_bond'}}\n", - "D:VAL:109 D:LEU:110 {'kind': {'peptide_bond'}}\n", - "D:LEU:110 D:VAL:111 {'kind': {'peptide_bond'}}\n", - "D:VAL:111 D:CYS:112 {'kind': {'peptide_bond'}}\n", - "D:CYS:112 D:VAL:113 {'kind': {'peptide_bond'}}\n", - "D:VAL:113 D:LEU:114 {'kind': {'peptide_bond'}}\n", - "D:LEU:114 D:ALA:115 {'kind': {'peptide_bond'}}\n", - "D:ALA:115 D:HIS:116 {'kind': {'peptide_bond'}}\n", - "D:HIS:116 D:HIS:117 {'kind': {'peptide_bond', 'aromatic'}}\n", - "D:HIS:117 D:PHE:118 {'kind': {'peptide_bond'}}\n", - "D:PHE:118 D:GLY:119 {'kind': {'peptide_bond'}}\n", - "D:GLY:119 D:LYS:120 {'kind': {'peptide_bond'}}\n", - "D:LYS:120 D:GLU:121 {'kind': {'peptide_bond', 'ionic'}}\n", - "D:GLU:121 D:PHE:122 {'kind': {'peptide_bond'}}\n", - "D:PHE:122 D:THR:123 {'kind': {'peptide_bond'}}\n", - "D:PHE:122 D:TYR:130 {'kind': {'aromatic'}}\n", - "D:THR:123 D:PRO:124 {'kind': {'peptide_bond'}}\n", - "D:PRO:124 D:PRO:125 {'kind': {'peptide_bond'}}\n", - "D:PRO:125 D:VAL:126 {'kind': {'peptide_bond'}}\n", - "D:VAL:126 D:GLN:127 {'kind': {'peptide_bond'}}\n", - "D:GLN:127 D:ALA:128 {'kind': {'peptide_bond'}}\n", - "D:ALA:128 D:ALA:129 {'kind': {'peptide_bond'}}\n", - "D:ALA:129 D:TYR:130 {'kind': {'peptide_bond'}}\n", - "D:TYR:130 D:GLN:131 {'kind': {'peptide_bond'}}\n", - "D:GLN:131 D:LYS:132 {'kind': {'peptide_bond'}}\n", - "D:LYS:132 D:VAL:133 {'kind': {'peptide_bond'}}\n", - "D:VAL:133 D:VAL:134 {'kind': {'peptide_bond'}}\n", - "D:VAL:134 D:ALA:135 {'kind': {'peptide_bond'}}\n", - "D:ALA:135 D:GLY:136 {'kind': {'peptide_bond'}}\n", - "D:GLY:136 D:VAL:137 {'kind': {'peptide_bond'}}\n", - "D:VAL:137 D:ALA:138 {'kind': {'peptide_bond'}}\n", - "D:ALA:138 D:ASN:139 {'kind': {'peptide_bond'}}\n", - "D:ASN:139 D:ALA:140 {'kind': {'peptide_bond'}}\n", - "D:ALA:140 D:LEU:141 {'kind': {'peptide_bond'}}\n", - "D:LEU:141 D:ALA:142 {'kind': {'peptide_bond'}}\n", - "D:ALA:142 D:HIS:143 {'kind': {'peptide_bond'}}\n", - "D:HIS:143 D:LYS:144 {'kind': {'peptide_bond'}}\n", - "D:LYS:144 D:TYR:145 {'kind': {'peptide_bond'}}\n", - "D:TYR:145 D:HIS:146 {'kind': {'peptide_bond'}}\n" + "MultiGraph named '4hhb' with 80 nodes and 107 edges\n", + "A:VAL:1 A:LEU:2 {'kind': {'peptide_bond'}, 'distance': 3.7034909207395117}\n", + "A:LEU:2 A:SER:3 {'kind': {'peptide_bond'}, 'distance': 3.8152731225955496}\n", + "A:SER:3 A:PRO:4 {'kind': {'peptide_bond'}, 'distance': 3.550879750146435}\n", + "A:SER:3 A:ASP:6 {'kind': {'hbond'}, 'distance': 5.085594262227374}\n", + "A:PRO:4 A:ALA:5 {'kind': {'peptide_bond'}, 'distance': 3.650173146578118}\n", + "A:ALA:5 A:ASP:6 {'kind': {'peptide_bond'}, 'distance': 4.045181083709355}\n", + "A:ASP:6 A:LYS:7 {'kind': {'peptide_bond', 'ionic'}, 'distance': 3.7467425852332035}\n", + "A:ASP:6 A:LYS:127 {'kind': {'ionic', 'hbond'}, 'distance': 7.868350017633938}\n", + "A:ASP:6 A:SER:124 {'kind': {'hbond'}, 'distance': 4.888939864633233}\n", + "A:ASP:6 C:ARG:141 {'kind': {'ionic'}, 'distance': 10.649982629093813}\n", + "A:LYS:7 A:THR:8 {'kind': {'peptide_bond'}, 'distance': 3.6363825431326697}\n", + "A:LYS:7 A:ASP:74 {'kind': {'ionic', 'hbond'}, 'distance': 8.732083199328782}\n", + "A:THR:8 A:ASN:9 {'kind': {'peptide_bond'}, 'distance': 3.5781394606694716}\n", + "A:ASN:9 A:VAL:10 {'kind': {'peptide_bond'}, 'distance': 3.906225543923444}\n", + "A:VAL:10 A:LYS:11 {'kind': {'peptide_bond'}, 'distance': 3.9556081706862742}\n", + "A:LYS:11 A:ALA:12 {'kind': {'peptide_bond'}, 'distance': 3.6039030231125824}\n", + "A:LYS:11 A:ASP:74 {'kind': {'ionic'}, 'distance': 11.800695615089815}\n", + "A:ALA:12 A:ALA:13 {'kind': {'peptide_bond'}, 'distance': 3.7537594488725565}\n", + "A:ALA:13 A:TRP:14 {'kind': {'peptide_bond'}, 'distance': 3.8350736629170497}\n", + "A:TRP:14 A:GLY:15 {'kind': {'peptide_bond'}, 'distance': 3.7128293793278484}\n", + "A:GLY:15 A:LYS:16 {'kind': {'peptide_bond'}, 'distance': 3.957959701664482}\n", + "A:LYS:16 A:VAL:17 {'kind': {'peptide_bond'}, 'distance': 3.6564928551824063}\n", + "A:LYS:16 A:GLU:116 {'kind': {'ionic'}, 'distance': 8.290879687946267}\n", + "A:VAL:17 A:GLY:18 {'kind': {'peptide_bond'}, 'distance': 3.7595346786537287}\n", + "A:GLY:18 A:ALA:19 {'kind': {'peptide_bond'}, 'distance': 3.72965534600719}\n", + "A:ALA:19 A:HIS:20 {'kind': {'peptide_bond'}, 'distance': 4.100412784098695}\n", + "A:HIS:20 A:ALA:21 {'kind': {'peptide_bond'}, 'distance': 3.9352642859152427}\n", + "A:HIS:20 A:GLU:23 {'kind': {'ionic'}, 'distance': 5.393241233247405}\n", + "A:HIS:20 A:HIS:112 {'kind': {'aromatic'}, 'distance': 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'distance': 3.7718666466353237}\n", + "A:LEU:106 A:VAL:107 {'kind': {'peptide_bond'}, 'distance': 3.660483438017443}\n", + "A:VAL:107 A:THR:108 {'kind': {'peptide_bond'}, 'distance': 3.78145514319554}\n", + "A:THR:108 A:LEU:109 {'kind': {'peptide_bond'}, 'distance': 3.8058663928204317}\n", + "A:LEU:109 A:ALA:110 {'kind': {'peptide_bond'}, 'distance': 3.7434617668676675}\n", + "A:ALA:110 A:ALA:111 {'kind': {'peptide_bond'}, 'distance': 3.8044592256981815}\n", + "A:ALA:111 A:HIS:112 {'kind': {'peptide_bond'}, 'distance': 3.8553968667311014}\n", + "A:HIS:112 A:LEU:113 {'kind': {'peptide_bond'}, 'distance': 3.9032565890548367}\n", + "A:LEU:113 A:PRO:114 {'kind': {'peptide_bond'}, 'distance': 3.981272660846026}\n", + "A:PRO:114 A:ALA:115 {'kind': {'peptide_bond'}, 'distance': 4.0137836264552185}\n", + "A:ALA:115 A:GLU:116 {'kind': {'peptide_bond'}, 'distance': 3.8783590602212152}\n", + "A:GLU:116 A:PHE:117 {'kind': {'peptide_bond'}, 'distance': 3.8456255667966426}\n", + "A:PHE:117 A:THR:118 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{'peptide_bond'}, 'distance': 3.7027510043209766}\n", + "B:ASN:139 B:ALA:140 {'kind': {'peptide_bond'}, 'distance': 3.7441418242368982}\n", + "B:ALA:140 B:LEU:141 {'kind': {'peptide_bond'}, 'distance': 3.857827627046082}\n", + "B:LEU:141 B:ALA:142 {'kind': {'peptide_bond'}, 'distance': 3.70349267583993}\n", + "B:ALA:142 B:HIS:143 {'kind': {'peptide_bond'}, 'distance': 4.0338647721508964}\n", + "B:HIS:143 B:LYS:144 {'kind': {'peptide_bond'}, 'distance': 3.9589945693319657}\n", + "B:LYS:144 B:TYR:145 {'kind': {'peptide_bond'}, 'distance': 3.810837309568593}\n", + "B:TYR:145 B:HIS:146 {'kind': {'peptide_bond'}, 'distance': 4.087356847646165}\n", + "C:VAL:1 C:LEU:2 {'kind': {'peptide_bond'}, 'distance': 3.8775725654073847}\n", + "C:LEU:2 C:SER:3 {'kind': {'peptide_bond'}, 'distance': 4.006659706039432}\n", + "C:SER:3 C:PRO:4 {'kind': {'peptide_bond'}, 'distance': 3.6847904960797986}\n", + "C:SER:3 C:ASP:6 {'kind': {'hbond'}, 'distance': 4.865286939122912}\n", + "C:PRO:4 C:ALA:5 {'kind': {'peptide_bond'}, 'distance': 3.6725338664197507}\n", + "C:ALA:5 C:ASP:6 {'kind': {'peptide_bond'}, 'distance': 3.7727243472058745}\n", + "C:ASP:6 C:LYS:7 {'kind': {'peptide_bond', 'ionic'}, 'distance': 4.005626417927663}\n", + "C:ASP:6 C:LYS:127 {'kind': {'ionic', 'hbond'}, 'distance': 8.14862675547236}\n", + "C:ASP:6 C:SER:124 {'kind': {'hbond'}, 'distance': 4.907562633324206}\n", + "C:LYS:7 C:THR:8 {'kind': {'peptide_bond'}, 'distance': 3.4943571654883807}\n", + "C:LYS:7 C:ASP:74 {'kind': {'ionic', 'hbond'}, 'distance': 9.291988699950084}\n", + "C:THR:8 C:ASN:9 {'kind': {'peptide_bond'}, 'distance': 3.7259600105207795}\n", + "C:ASN:9 C:VAL:10 {'kind': {'peptide_bond'}, 'distance': 3.5529821277343907}\n", + "C:VAL:10 C:LYS:11 {'kind': {'peptide_bond'}, 'distance': 3.925168149264438}\n", + "C:LYS:11 C:ALA:12 {'kind': {'peptide_bond'}, 'distance': 3.3464413934805415}\n", + "C:LYS:11 C:ASP:74 {'kind': {'ionic'}, 'distance': 12.451037667600241}\n", + "C:ALA:12 C:ALA:13 {'kind': {'peptide_bond'}, 'distance': 3.764730800469007}\n", + "C:ALA:13 C:TRP:14 {'kind': {'peptide_bond'}, 'distance': 3.8265318501222487}\n", + "C:TRP:14 C:GLY:15 {'kind': {'peptide_bond'}, 'distance': 3.97740593854839}\n", + "C:GLY:15 C:LYS:16 {'kind': {'peptide_bond'}, 'distance': 3.805731861285027}\n", + "C:LYS:16 C:VAL:17 {'kind': {'peptide_bond'}, 'distance': 4.109562628796403}\n", + "C:LYS:16 C:GLU:116 {'kind': {'ionic'}, 'distance': 8.05763228250086}\n", + "C:VAL:17 C:GLY:18 {'kind': {'peptide_bond'}, 'distance': 3.6221000814444655}\n", + "C:GLY:18 C:ALA:19 {'kind': {'peptide_bond'}, 'distance': 3.275322274219746}\n", + "C:ALA:19 C:HIS:20 {'kind': {'peptide_bond'}, 'distance': 3.9930320559694987}\n", + "C:HIS:20 C:ALA:21 {'kind': {'peptide_bond'}, 'distance': 3.9695965789989294}\n", + "C:HIS:20 C:GLU:23 {'kind': {'ionic'}, 'distance': 5.207734440234063}\n", + "C:HIS:20 C:HIS:112 {'kind': {'aromatic'}, 'distance': 9.756426958677034}\n", + "C:HIS:20 C:TYR:24 {'kind': {'aromatic'}, 'distance': 6.0903580354524305}\n", + "C:ALA:21 C:GLY:22 {'kind': {'peptide_bond'}, 'distance': 3.791688542061439}\n", + "C:GLY:22 C:GLU:23 {'kind': {'peptide_bond'}, 'distance': 3.719965188009158}\n", + "C:GLU:23 C:TYR:24 {'kind': {'peptide_bond'}, 'distance': 3.8054751345922617}\n", + "C:GLU:23 C:HIS:112 {'kind': {'ionic'}, 'distance': 10.858536964066568}\n", + "C:TYR:24 C:GLY:25 {'kind': {'peptide_bond'}, 'distance': 3.7460529894810604}\n", + "C:GLY:25 C:ALA:26 {'kind': {'peptide_bond'}, 'distance': 3.870238235561216}\n", + "C:ALA:26 C:GLU:27 {'kind': {'peptide_bond'}, 'distance': 3.867722585708547}\n", + "C:GLU:27 C:ALA:28 {'kind': {'peptide_bond'}, 'distance': 3.9923777376395635}\n", + "C:GLU:27 C:HIS:112 {'kind': {'ionic'}, 'distance': 10.766046860384732}\n", + "C:GLU:27 C:ARG:31 {'kind': {'ionic'}, 'distance': 6.009305617124163}\n", + "C:ALA:28 C:LEU:29 {'kind': {'peptide_bond'}, 'distance': 3.8663786674354603}\n", + "C:LEU:29 C:GLU:30 {'kind': {'peptide_bond'}, 'distance': 3.684418135879803}\n", + "C:GLU:30 C:ARG:31 {'kind': {'peptide_bond', 'ionic'}, 'distance': 3.7262886361633343}\n", + "C:GLU:30 C:HIS:50 {'kind': {'ionic'}, 'distance': 7.488527959485762}\n", + "C:ARG:31 C:MET:32 {'kind': {'peptide_bond'}, 'distance': 3.9184787864680333}\n", + "C:MET:32 C:PHE:33 {'kind': {'peptide_bond'}, 'distance': 3.8508579563520655}\n", + "C:PHE:33 C:LEU:34 {'kind': {'peptide_bond'}, 'distance': 3.8185368925807173}\n", + "C:PHE:33 C:PHE:43 {'kind': {'aromatic'}, 'distance': 9.780550546876185}\n", + "C:LEU:34 C:SER:35 {'kind': {'peptide_bond'}, 'distance': 3.7321588926518126}\n", + "C:SER:35 C:PHE:36 {'kind': {'peptide_bond'}, 'distance': 3.8248503238688962}\n", + "C:PHE:36 C:PRO:37 {'kind': {'peptide_bond'}, 'distance': 3.6683914731118863}\n", + "C:PHE:36 C:HIS:103 {'kind': {'aromatic'}, 'distance': 10.85358507590925}\n", + "C:PRO:37 C:THR:38 {'kind': {'peptide_bond'}, 'distance': 3.8975166452498957}\n", + "C:THR:38 C:THR:39 {'kind': {'peptide_bond'}, 'distance': 3.583451967028441}\n", + "C:THR:39 C:LYS:40 {'kind': {'peptide_bond'}, 'distance': 3.889897427953595}\n", + "C:LYS:40 C:THR:41 {'kind': {'peptide_bond'}, 'distance': 3.8737156581246373}\n", + "C:THR:41 C:TYR:42 {'kind': {'peptide_bond'}, 'distance': 3.938326294252421}\n", + "C:TYR:42 C:PHE:43 {'kind': {'peptide_bond'}, 'distance': 3.9439632351227614}\n", + "C:PHE:43 C:PRO:44 {'kind': {'peptide_bond'}, 'distance': 3.8459284964752016}\n", + "C:PHE:43 C:HIS:58 {'kind': {'aromatic'}, 'distance': 10.697640861423606}\n", + "C:PHE:43 C:PHE:46 {'kind': {'aromatic'}, 'distance': 5.412918066994916}\n", + "C:PRO:44 C:HIS:45 {'kind': {'peptide_bond'}, 'distance': 3.8919195777919136}\n", + "C:HIS:45 C:PHE:46 {'kind': {'aromatic', 'peptide_bond'}, 'distance': 3.656513913552087}\n", + "C:PHE:46 C:ASP:47 {'kind': {'peptide_bond'}, 'distance': 3.8335780936352397}\n", + "C:PHE:46 C:HIS:58 {'kind': {'aromatic'}, 'distance': 9.953169645896727}\n", + "C:ASP:47 C:LEU:48 {'kind': {'peptide_bond'}, 'distance': 3.8204336141333495}\n", + "C:ASP:47 C:SER:49 {'kind': {'hbond'}, 'distance': 5.693468275137748}\n", + "C:LEU:48 C:SER:49 {'kind': {'peptide_bond'}, 'distance': 3.966926013930685}\n", + "C:SER:49 C:HIS:50 {'kind': {'peptide_bond'}, 'distance': 3.6413626570282713}\n", + "C:HIS:50 C:GLY:51 {'kind': {'peptide_bond'}, 'distance': 3.721679459598851}\n", + "C:GLY:51 C:SER:52 {'kind': {'peptide_bond'}, 'distance': 3.8170068116260927}\n", + "C:SER:52 C:ALA:53 {'kind': {'peptide_bond'}, 'distance': 3.819365654136823}\n", + "C:ALA:53 C:GLN:54 {'kind': {'peptide_bond'}, 'distance': 3.605090012745867}\n", + "C:GLN:54 C:VAL:55 {'kind': {'peptide_bond'}, 'distance': 4.012133846221986}\n", + "C:VAL:55 C:LYS:56 {'kind': {'peptide_bond'}, 'distance': 3.8360376692623857}\n", + "C:LYS:56 C:GLY:57 {'kind': {'peptide_bond'}, 'distance': 3.6246059096127965}\n", + "C:GLY:57 C:HIS:58 {'kind': {'peptide_bond'}, 'distance': 3.758625812714002}\n", + "C:HIS:58 C:GLY:59 {'kind': {'peptide_bond'}, 'distance': 3.6640302946345855}\n", + "C:GLY:59 C:LYS:60 {'kind': {'peptide_bond'}, 'distance': 3.7482270475519486}\n", + "C:LYS:60 C:LYS:61 {'kind': {'peptide_bond'}, 'distance': 3.6509442614205985}\n", + "C:LYS:60 C:ASP:64 {'kind': {'ionic', 'hbond'}, 'distance': 6.0900643674759305}\n", + "C:LYS:61 C:VAL:62 {'kind': {'peptide_bond'}, 'distance': 3.948445896805475}\n", + "C:LYS:61 C:ASP:64 {'kind': {'ionic'}, 'distance': 5.2826608825477335}\n", + "C:VAL:62 C:ALA:63 {'kind': {'peptide_bond'}, 'distance': 3.714216606499951}\n", + "C:ALA:63 C:ASP:64 {'kind': {'peptide_bond'}, 'distance': 3.694282880343627}\n", + "C:ASP:64 C:ALA:65 {'kind': {'peptide_bond'}, 'distance': 3.728836413681887}\n", + "C:ALA:65 C:LEU:66 {'kind': {'peptide_bond'}, 'distance': 4.016348714939976}\n", + "C:LEU:66 C:THR:67 {'kind': {'peptide_bond'}, 'distance': 3.8360894150162874}\n", + "C:THR:67 C:ASN:68 {'kind': {'peptide_bond'}, 'distance': 3.7238805029162787}\n", + "C:ASN:68 C:ALA:69 {'kind': {'peptide_bond'}, 'distance': 3.8703618693863753}\n", + "C:ALA:69 C:VAL:70 {'kind': {'peptide_bond'}, 'distance': 3.9775648329097026}\n", + "C:VAL:70 C:ALA:71 {'kind': {'peptide_bond'}, 'distance': 3.9954970904757285}\n", + "C:ALA:71 C:HIS:72 {'kind': {'peptide_bond'}, 'distance': 3.6098256190569638}\n", + "C:HIS:72 C:VAL:73 {'kind': {'peptide_bond'}, 'distance': 3.372391139829424}\n", + "C:HIS:72 C:ASP:75 {'kind': {'ionic'}, 'distance': 5.661638985311586}\n", + "C:VAL:73 C:ASP:74 {'kind': {'peptide_bond'}, 'distance': 3.948483506360387}\n", + "C:ASP:74 C:ASP:75 {'kind': {'peptide_bond'}, 'distance': 3.8311188966149303}\n", + "C:ASP:75 C:MET:76 {'kind': {'peptide_bond'}, 'distance': 3.797607799654938}\n", + "C:MET:76 C:PRO:77 {'kind': {'peptide_bond'}, 'distance': 3.5743879196304364}\n", + "C:PRO:77 C:ASN:78 {'kind': {'peptide_bond'}, 'distance': 3.63624132862493}\n", + "C:ASN:78 C:ALA:79 {'kind': {'peptide_bond'}, 'distance': 3.4125341023937037}\n", + "C:ALA:79 C:LEU:80 {'kind': {'peptide_bond'}, 'distance': 3.8633226632006816}\n", + "C:LEU:80 C:SER:81 {'kind': {'peptide_bond'}, 'distance': 4.000043624762109}\n", + "C:SER:81 C:ALA:82 {'kind': {'peptide_bond'}, 'distance': 3.7343647384796257}\n", + "C:SER:81 C:LYS:139 {'kind': {'hbond'}, 'distance': 9.112781463417193}\n", + "C:ALA:82 C:LEU:83 {'kind': {'peptide_bond'}, 'distance': 3.7849231167885056}\n", + "C:LEU:83 C:SER:84 {'kind': {'peptide_bond'}, 'distance': 3.8283184298070085}\n", + "C:SER:84 C:ASP:85 {'kind': {'peptide_bond'}, 'distance': 3.8300827667297215}\n", + "C:ASP:85 C:LEU:86 {'kind': {'peptide_bond'}, 'distance': 3.6144861322185213}\n", + "C:ASP:85 C:LYS:139 {'kind': {'ionic', 'hbond'}, 'distance': 6.713061522137274}\n", + "C:ASP:85 C:HIS:89 {'kind': {'ionic'}, 'distance': 5.753414116852705}\n", + "C:LEU:86 C:HIS:87 {'kind': {'peptide_bond'}, 'distance': 3.644282508258657}\n", + "C:HIS:87 C:ALA:88 {'kind': {'peptide_bond'}, 'distance': 3.895893479036612}\n", + "C:HIS:87 C:PHE:98 {'kind': {'aromatic'}, 'distance': 11.023955959636268}\n", + "C:HIS:87 C:TYR:140 {'kind': {'aromatic'}, 'distance': 8.065680256494177}\n", + "C:ALA:88 C:HIS:89 {'kind': {'peptide_bond'}, 'distance': 3.91743959749222}\n", + "C:HIS:89 C:LYS:90 {'kind': {'peptide_bond'}, 'distance': 3.5852171482352366}\n", + "C:LYS:90 C:LEU:91 {'kind': {'peptide_bond'}, 'distance': 3.94743030337459}\n", + "C:LEU:91 C:ARG:92 {'kind': {'peptide_bond'}, 'distance': 3.7970890166020594}\n", + "C:ARG:92 C:VAL:93 {'kind': {'peptide_bond'}, 'distance': 3.8993094260394368}\n", + "C:VAL:93 C:ASP:94 {'kind': {'peptide_bond'}, 'distance': 3.6307174222183702}\n", + "C:ASP:94 C:PRO:95 {'kind': {'peptide_bond'}, 'distance': 3.9103818227891756}\n", + "C:PRO:95 C:VAL:96 {'kind': {'peptide_bond'}, 'distance': 3.829540311839007}\n", + "C:VAL:96 C:ASN:97 {'kind': {'peptide_bond'}, 'distance': 3.7859286839558934}\n", + "C:ASN:97 C:PHE:98 {'kind': {'peptide_bond'}, 'distance': 3.693358498710895}\n", + "C:PHE:98 C:LYS:99 {'kind': {'peptide_bond'}, 'distance': 3.8010568267259566}\n", + "C:PHE:98 C:TYR:140 {'kind': {'aromatic'}, 'distance': 13.205452320916539}\n", + "C:LYS:99 C:LEU:100 {'kind': {'peptide_bond'}, 'distance': 3.7360689233471054}\n", + "C:LEU:100 C:LEU:101 {'kind': {'peptide_bond'}, 'distance': 3.7383565908029706}\n", + "C:LEU:101 C:SER:102 {'kind': {'peptide_bond'}, 'distance': 3.912030930348072}\n", + "C:SER:102 C:HIS:103 {'kind': {'peptide_bond'}, 'distance': 3.901268127160706}\n", + "C:HIS:103 C:CYS:104 {'kind': {'peptide_bond'}, 'distance': 3.9119608893750457}\n", + "C:CYS:104 C:LEU:105 {'kind': {'peptide_bond'}, 'distance': 3.6228884884853962}\n", + "C:LEU:105 C:LEU:106 {'kind': {'peptide_bond'}, 'distance': 3.778198909533483}\n", + "C:LEU:106 C:VAL:107 {'kind': {'peptide_bond'}, 'distance': 3.699843645345029}\n", + "C:VAL:107 C:THR:108 {'kind': {'peptide_bond'}, 'distance': 3.892438824182084}\n", + "C:THR:108 C:LEU:109 {'kind': {'peptide_bond'}, 'distance': 3.9238298892790957}\n", + "C:LEU:109 C:ALA:110 {'kind': {'peptide_bond'}, 'distance': 3.8960968930456543}\n", + "C:ALA:110 C:ALA:111 {'kind': {'peptide_bond'}, 'distance': 3.879375465200552}\n", + "C:ALA:111 C:HIS:112 {'kind': {'peptide_bond'}, 'distance': 3.912249225190031}\n", + "C:HIS:112 C:LEU:113 {'kind': {'peptide_bond'}, 'distance': 3.855817034040905}\n", + "C:LEU:113 C:PRO:114 {'kind': {'peptide_bond'}, 'distance': 4.231268840430729}\n", + "C:PRO:114 C:ALA:115 {'kind': {'peptide_bond'}, 'distance': 3.973501981879461}\n", + "C:ALA:115 C:GLU:116 {'kind': {'peptide_bond'}, 'distance': 3.6929149732968414}\n", + "C:GLU:116 C:PHE:117 {'kind': {'peptide_bond'}, 'distance': 3.866725875983452}\n", + "C:PHE:117 C:THR:118 {'kind': {'peptide_bond'}, 'distance': 3.7001520239038825}\n", + "C:PHE:117 D:HIS:116 {'kind': {'aromatic'}, 'distance': 7.398833016091118}\n", + "C:THR:118 C:PRO:119 {'kind': {'peptide_bond'}, 'distance': 3.7556030141643033}\n", + "C:PRO:119 C:ALA:120 {'kind': {'peptide_bond'}, 'distance': 3.7078836281631062}\n", + "C:ALA:120 C:VAL:121 {'kind': {'peptide_bond'}, 'distance': 3.88067172020515}\n", + "C:VAL:121 C:HIS:122 {'kind': {'peptide_bond'}, 'distance': 3.887918337619761}\n", + "C:HIS:122 C:ALA:123 {'kind': {'peptide_bond'}, 'distance': 3.795530792919482}\n", + "C:HIS:122 C:ASP:126 {'kind': {'ionic'}, 'distance': 6.1640785199411585}\n", + "C:ALA:123 C:SER:124 {'kind': {'peptide_bond'}, 'distance': 3.7953630919847443}\n", + "C:SER:124 C:LEU:125 {'kind': {'peptide_bond'}, 'distance': 3.797296406655662}\n", + "C:LEU:125 C:ASP:126 {'kind': {'peptide_bond'}, 'distance': 3.849516722914708}\n", + "C:ASP:126 C:LYS:127 {'kind': {'peptide_bond', 'ionic'}, 'distance': 3.8413297176889154}\n", + "C:LYS:127 C:PHE:128 {'kind': {'peptide_bond'}, 'distance': 3.7160481697631425}\n", + "C:PHE:128 C:LEU:129 {'kind': {'peptide_bond'}, 'distance': 3.9912585734326966}\n", + "C:LEU:129 C:ALA:130 {'kind': {'peptide_bond'}, 'distance': 3.8986200122607477}\n", + "C:ALA:130 C:SER:131 {'kind': {'peptide_bond'}, 'distance': 3.8073220247307686}\n", + "C:SER:131 C:VAL:132 {'kind': {'peptide_bond'}, 'distance': 3.932126269590029}\n", + "C:VAL:132 C:SER:133 {'kind': {'peptide_bond'}, 'distance': 3.8209085307031354}\n", + "C:SER:133 C:THR:134 {'kind': {'peptide_bond'}, 'distance': 3.8447051902584155}\n", + "C:THR:134 C:VAL:135 {'kind': {'peptide_bond'}, 'distance': 3.752315685013722}\n", + "C:VAL:135 C:LEU:136 {'kind': {'peptide_bond'}, 'distance': 3.96373788235297}\n", + "C:LEU:136 C:THR:137 {'kind': {'peptide_bond'}, 'distance': 3.884797292008941}\n", + "C:THR:137 C:SER:138 {'kind': {'peptide_bond'}, 'distance': 3.967409860349697}\n", + "C:SER:138 C:LYS:139 {'kind': {'peptide_bond'}, 'distance': 3.8928808098887377}\n", + "C:LYS:139 C:TYR:140 {'kind': {'peptide_bond'}, 'distance': 3.857959823533676}\n", + "C:TYR:140 C:ARG:141 {'kind': {'peptide_bond'}, 'distance': 3.7048657195639367}\n", + "D:VAL:1 D:HIS:2 {'kind': {'peptide_bond'}, 'distance': 3.6628942108665936}\n", + "D:HIS:2 D:LEU:3 {'kind': {'peptide_bond'}, 'distance': 3.685796657440559}\n", + "D:HIS:2 D:GLU:7 {'kind': {'ionic'}, 'distance': 9.194536801818787}\n", + "D:LEU:3 D:THR:4 {'kind': {'peptide_bond'}, 'distance': 3.9078458260274282}\n", + "D:THR:4 D:PRO:5 {'kind': {'peptide_bond'}, 'distance': 3.8759455620532126}\n", + "D:PRO:5 D:GLU:6 {'kind': {'peptide_bond'}, 'distance': 3.6760138737496613}\n", + "D:GLU:6 D:GLU:7 {'kind': {'peptide_bond'}, 'distance': 4.2422735649649015}\n", + "D:GLU:7 D:LYS:8 {'kind': {'peptide_bond', 'ionic'}, 'distance': 4.033357658328853}\n", + "D:GLU:7 D:LYS:132 {'kind': {'ionic'}, 'distance': 9.327949238712655}\n", + "D:LYS:8 D:SER:9 {'kind': {'peptide_bond'}, 'distance': 3.56386812326158}\n", + "D:LYS:8 D:ASP:79 {'kind': {'ionic'}, 'distance': 10.570025685872292}\n", + "D:SER:9 D:ALA:10 {'kind': {'peptide_bond'}, 'distance': 3.664226384927658}\n", + "D:ALA:10 D:VAL:11 {'kind': {'peptide_bond'}, 'distance': 4.130785034348799}\n", + "D:VAL:11 D:THR:12 {'kind': {'peptide_bond'}, 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{'kind': {'peptide_bond'}, 'distance': 3.8361088357865976}\n", + "D:ALA:135 D:GLY:136 {'kind': {'peptide_bond'}, 'distance': 3.9301609381805207}\n", + "D:GLY:136 D:VAL:137 {'kind': {'peptide_bond'}, 'distance': 3.687239346719982}\n", + "D:VAL:137 D:ALA:138 {'kind': {'peptide_bond'}, 'distance': 3.799582740249251}\n", + "D:ALA:138 D:ASN:139 {'kind': {'peptide_bond'}, 'distance': 3.7314032213096455}\n", + "D:ASN:139 D:ALA:140 {'kind': {'peptide_bond'}, 'distance': 4.008666611231221}\n", + "D:ALA:140 D:LEU:141 {'kind': {'peptide_bond'}, 'distance': 3.822226707038713}\n", + "D:LEU:141 D:ALA:142 {'kind': {'peptide_bond'}, 'distance': 3.835355133491552}\n", + "D:ALA:142 D:HIS:143 {'kind': {'peptide_bond'}, 'distance': 3.836136598193552}\n", + "D:HIS:143 D:LYS:144 {'kind': {'peptide_bond'}, 'distance': 3.917826055352637}\n", + "D:LYS:144 D:TYR:145 {'kind': {'peptide_bond'}, 'distance': 3.656940387810555}\n", + "D:TYR:145 D:HIS:146 {'kind': {'peptide_bond'}, 'distance': 3.935869662476135}\n" + ] + }, + { + "name": "stderr", + "output_type": "stream", + "text": [ + "/var/folders/p1/0qtk6t_520n7k4bvk1p26l_w0000gn/T/ipykernel_29050/3519097318.py:2: DeprecationWarning:\n", + "\n", + "info is deprecated and will be removed in version 3.0.\n", + "\n", + "\n" ] } ], @@ -28597,6 +28646,10 @@ "name": "stderr", "output_type": "stream", "text": [ + "/Users/arianjamasb/github/graphein/graphein/protein/visualisation.py:943: FutureWarning:\n", + "\n", + "adjacency_matrix will return a scipy.sparse array instead of a matrix in Networkx 3.0.\n", + "\n", "/Users/arianjamasb/opt/anaconda3/envs/graphein-wip/lib/python3.8/site-packages/mpl_chord_diagram/utilities.py:11: RuntimeWarning:\n", "\n", "invalid value encountered in true_divide\n", @@ -28630,20 +28683,16 @@ "name": "stdout", "output_type": "stream", "text": [ - "Name: 4hhb\n", - "Type: Graph\n", - "Number of nodes: 80\n", - "Number of edges: 86\n", - "Average degree: 2.1500\n", - "H1 H7 {'weight': 3, 'kind': {'hbond', 'ionic'}, 'hbond': 2, 'ionic': 1}\n", - "H1 G2 {'weight': 3, 'kind': {'hbond', 'ionic'}, 'hbond': 1, 'ionic': 2}\n", + "Graph named '4hhb' with 80 nodes and 86 edges\n", + "H1 H7 {'weight': 3, 'kind': {'ionic', 'hbond'}, 'ionic': 1, 'hbond': 2}\n", + "H1 G2 {'weight': 3, 'kind': {'ionic', 'hbond'}, 'ionic': 2, 'hbond': 1}\n", "H1 T7 {'weight': 1, 'kind': {'ionic'}, 'ionic': 1}\n", "H1 T1 {'weight': 1, 'kind': {'peptide_bond'}, 'peptide_bond': 1}\n", "T1 H2 {'weight': 2, 'kind': {'peptide_bond', 'ionic'}, 'peptide_bond': 1, 'ionic': 1}\n", "T1 H6 {'weight': 1, 'kind': {'aromatic'}, 'aromatic': 1}\n", "H2 H6 {'weight': 2, 'kind': {'ionic'}, 'ionic': 2}\n", "H2 T3 {'weight': 1, 'kind': {'ionic'}, 'ionic': 1}\n", - "T2 S1 {'weight': 2, 'kind': {'peptide_bond', 'aromatic'}, 'peptide_bond': 1, 'aromatic': 1}\n", + "T2 S1 {'weight': 2, 'kind': {'aromatic', 'peptide_bond'}, 'aromatic': 1, 'peptide_bond': 1}\n", "S1 H3 {'weight': 1, 'kind': {'aromatic'}, 'aromatic': 1}\n", "S2 T3 {'weight': 1, 'kind': {'peptide_bond'}, 'peptide_bond': 1}\n", "H3 T4 {'weight': 1, 'kind': {'peptide_bond'}, 'peptide_bond': 1}\n", @@ -28651,7 +28700,7 @@ "G2 H4 {'weight': 2, 'kind': {'peptide_bond', 'hbond'}, 'peptide_bond': 1, 'hbond': 1}\n", "H4 T5 {'weight': 1, 'kind': {'peptide_bond'}, 'peptide_bond': 1}\n", "T5 H5 {'weight': 1, 'kind': {'peptide_bond'}, 'peptide_bond': 1}\n", - "H5 T8 {'weight': 3, 'kind': {'hbond', 'ionic'}, 'hbond': 2, 'ionic': 1}\n", + "H5 T8 {'weight': 3, 'kind': {'ionic', 'hbond'}, 'hbond': 2, 'ionic': 1}\n", "H5 I1 {'weight': 2, 'kind': {'peptide_bond', 'ionic'}, 'peptide_bond': 1, 'ionic': 1}\n", "I1 H6 {'weight': 1, 'kind': {'aromatic'}, 'aromatic': 1}\n", "T6 H6 {'weight': 1, 'kind': {'peptide_bond'}, 'peptide_bond': 1}\n", @@ -28678,15 +28727,15 @@ "G6 S5 {'weight': 1, 'kind': {'peptide_bond'}, 'peptide_bond': 1}\n", "S5 H14 {'weight': 1, 'kind': {'aromatic'}, 'aromatic': 1}\n", "H14 T12 {'weight': 1, 'kind': {'peptide_bond'}, 'peptide_bond': 1}\n", - "H15 H21 {'weight': 3, 'kind': {'hbond', 'ionic'}, 'hbond': 2, 'ionic': 1}\n", - "H15 G9 {'weight': 3, 'kind': {'hbond', 'ionic'}, 'hbond': 1, 'ionic': 2}\n", + "H15 H21 {'weight': 3, 'kind': {'ionic', 'hbond'}, 'ionic': 1, 'hbond': 2}\n", + "H15 G9 {'weight': 3, 'kind': {'ionic', 'hbond'}, 'ionic': 2, 'hbond': 1}\n", "H15 T18 {'weight': 1, 'kind': {'ionic'}, 'ionic': 1}\n", "H15 G7 {'weight': 1, 'kind': {'peptide_bond'}, 'peptide_bond': 1}\n", - "G7 H16 {'weight': 3, 'kind': {'peptide_bond', 'aromatic', 'ionic'}, 'peptide_bond': 1, 'ionic': 1, 'aromatic': 1}\n", + "G7 H16 {'weight': 3, 'kind': {'aromatic', 'peptide_bond', 'ionic'}, 'peptide_bond': 1, 'ionic': 1, 'aromatic': 1}\n", "G7 H20 {'weight': 1, 'kind': {'aromatic'}, 'aromatic': 1}\n", "H16 H20 {'weight': 2, 'kind': {'ionic'}, 'ionic': 2}\n", "H16 T14 {'weight': 1, 'kind': {'ionic'}, 'ionic': 1}\n", - "T13 S6 {'weight': 2, 'kind': {'peptide_bond', 'aromatic'}, 'peptide_bond': 1, 'aromatic': 1}\n", + "T13 S6 {'weight': 2, 'kind': {'aromatic', 'peptide_bond'}, 'aromatic': 1, 'peptide_bond': 1}\n", "S6 H17 {'weight': 1, 'kind': {'aromatic'}, 'aromatic': 1}\n", "S7 T14 {'weight': 1, 'kind': {'peptide_bond'}, 'peptide_bond': 1}\n", "H17 T15 {'weight': 1, 'kind': {'peptide_bond'}, 'peptide_bond': 1}\n", @@ -28694,7 +28743,7 @@ "G9 H18 {'weight': 1, 'kind': {'peptide_bond'}, 'peptide_bond': 1}\n", "H18 T16 {'weight': 1, 'kind': {'peptide_bond'}, 'peptide_bond': 1}\n", "T16 H19 {'weight': 1, 'kind': {'peptide_bond'}, 'peptide_bond': 1}\n", - "H19 T19 {'weight': 3, 'kind': {'hbond', 'ionic'}, 'hbond': 2, 'ionic': 1}\n", + "H19 T19 {'weight': 3, 'kind': {'ionic', 'hbond'}, 'hbond': 2, 'ionic': 1}\n", "H19 I3 {'weight': 2, 'kind': {'peptide_bond', 'ionic'}, 'ionic': 1, 'peptide_bond': 1}\n", "I3 H20 {'weight': 1, 'kind': {'aromatic'}, 'aromatic': 1}\n", "T17 H20 {'weight': 1, 'kind': {'peptide_bond'}, 'peptide_bond': 1}\n", @@ -28703,7 +28752,7 @@ "H22 T23 {'weight': 1, 'kind': {'ionic'}, 'ionic': 1}\n", "H22 T20 {'weight': 1, 'kind': {'peptide_bond'}, 'peptide_bond': 1}\n", "T20 G12 {'weight': 1, 'kind': {'ionic'}, 'ionic': 1}\n", - "H23 H25 {'weight': 2, 'kind': {'hbond', 'ionic'}, 'hbond': 1, 'ionic': 1}\n", + "H23 H25 {'weight': 2, 'kind': {'ionic', 'hbond'}, 'ionic': 1, 'hbond': 1}\n", "H23 H27 {'weight': 3, 'kind': {'ionic'}, 'ionic': 3}\n", "H23 S8 {'weight': 1, 'kind': {'peptide_bond'}, 'peptide_bond': 1}\n", "S8 G10 {'weight': 1, 'kind': {'peptide_bond'}, 'peptide_bond': 1}\n", @@ -28722,6 +28771,17 @@ "S11 H28 {'weight': 1, 'kind': {'aromatic'}, 'aromatic': 1}\n", "H28 T25 {'weight': 1, 'kind': {'peptide_bond'}, 'peptide_bond': 1}\n" ] + }, + { + "name": "stderr", + "output_type": "stream", + "text": [ + "/var/folders/p1/0qtk6t_520n7k4bvk1p26l_w0000gn/T/ipykernel_29050/526239525.py:2: DeprecationWarning:\n", + "\n", + "info is deprecated and will be removed in version 3.0.\n", + "\n", + "\n" + ] } ], "source": [ @@ -28746,15 +28806,56 @@ "execution_count": 7, "metadata": {}, "outputs": [ + { + 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"A A {'weight': 587, 'kind': {'aromatic', 'ionic', 'peptide_bond', 'hbond'}, 'peptide_bond': 512, 'hbond': 11, 'ionic': 18, 'aromatic': 46}\n", + "A A {'weight': 587, 'kind': {'peptide_bond', 'ionic', 'aromatic', 'hbond'}, 'peptide_bond': 512, 'ionic': 18, 'hbond': 11, 'aromatic': 46}\n", "A L {'weight': 8, 'kind': {'aromatic', 'ionic'}, 'ionic': 4, 'aromatic': 4}\n", "A J {'weight': 1, 'kind': {'aromatic'}, 'aromatic': 1}\n", "A B {'weight': 17, 'kind': {'aromatic', 'ionic', 'hbond'}, 'hbond': 5, 'ionic': 10, 'aromatic': 2}\n", "A C {'weight': 8, 'kind': {'aromatic', 'ionic'}, 'ionic': 5, 'aromatic': 3}\n", - "A T {'weight': 2, 'kind': {'hbond', 'aromatic'}, 'hbond': 1, 'aromatic': 1}\n", + "A T {'weight': 2, 'kind': {'aromatic', 'hbond'}, 'hbond': 1, 'aromatic': 1}\n", "A G {'weight': 1, 'kind': {'hbond'}, 'hbond': 1}\n", "A D {'weight': 2, 'kind': {'ionic'}, 'ionic': 2}\n", "A M {'weight': 2, 'kind': {'ionic'}, 'ionic': 2}\n", - "A F {'weight': 3, 'kind': {'hbond', 'aromatic', 'ionic'}, 'ionic': 1, 'aromatic': 1, 'hbond': 1}\n", - "B B {'weight': 257, 'kind': {'aromatic', 'ionic', 'peptide_bond', 'hbond'}, 'peptide_bond': 226, 'aromatic': 5, 'ionic': 21, 'hbond': 5}\n", + "A F {'weight': 3, 'kind': {'aromatic', 'ionic', 'hbond'}, 'ionic': 1, 'aromatic': 1, 'hbond': 1}\n", + "B B {'weight': 257, 'kind': {'aromatic', 'peptide_bond', 'ionic', 'hbond'}, 'peptide_bond': 226, 'aromatic': 5, 'ionic': 21, 'hbond': 5}\n", "B D {'weight': 3, 'kind': {'aromatic', 'ionic'}, 'aromatic': 1, 'ionic': 2}\n", - "B I {'weight': 7, 'kind': {'hbond', 'aromatic', 'ionic'}, 'hbond': 1, 'ionic': 2, 'aromatic': 4}\n", + "B I {'weight': 7, 'kind': {'aromatic', 'ionic', 'hbond'}, 'ionic': 2, 'hbond': 1, 'aromatic': 4}\n", "B E {'weight': 1, 'kind': {'ionic'}, 'ionic': 1}\n", - "B H {'weight': 3, 'kind': {'hbond', 'ionic'}, 'hbond': 1, 'ionic': 2}\n", - "C C {'weight': 318, 'kind': {'aromatic', 'ionic', 'peptide_bond', 'hbond'}, 'peptide_bond': 258, 'aromatic': 42, 'ionic': 15, 'hbond': 3}\n", + "B H {'weight': 3, 'kind': {'ionic', 'hbond'}, 'hbond': 1, 'ionic': 2}\n", + "C C {'weight': 318, 'kind': {'aromatic', 'peptide_bond', 'ionic', 'hbond'}, 'peptide_bond': 258, 'aromatic': 42, 'ionic': 15, 'hbond': 3}\n", "C J {'weight': 4, 'kind': {'aromatic', 'ionic'}, 'ionic': 3, 'aromatic': 1}\n", "C F {'weight': 3, 'kind': {'ionic'}, 'ionic': 3}\n", "C T {'weight': 1, 'kind': {'aromatic'}, 'aromatic': 1}\n", - "C H {'weight': 1, 'kind': {'ionic'}, 'ionic': 1}\n", "C G {'weight': 7, 'kind': {'aromatic', 'ionic'}, 'ionic': 6, 'aromatic': 1}\n", - "D D {'weight': 184, 'kind': {'aromatic', 'ionic', 'peptide_bond', 'hbond'}, 'peptide_bond': 143, 'ionic': 31, 'hbond': 6, 'aromatic': 4}\n", - "D M {'weight': 4, 'kind': {'hbond', 'aromatic'}, 'hbond': 1, 'aromatic': 3}\n", - "D E {'weight': 9, 'kind': {'hbond', 'ionic'}, 'ionic': 6, 'hbond': 3}\n", - "D K {'weight': 5, 'kind': {'hbond', 'aromatic', 'ionic'}, 'ionic': 3, 'hbond': 1, 'aromatic': 1}\n", - "D I {'weight': 3, 'kind': {'hbond', 'ionic'}, 'hbond': 1, 'ionic': 2}\n", - "E E {'weight': 129, 'kind': {'aromatic', 'ionic', 'peptide_bond', 'hbond'}, 'peptide_bond': 103, 'ionic': 22, 'aromatic': 2, 'hbond': 2}\n", + "C H {'weight': 1, 'kind': {'ionic'}, 'ionic': 1}\n", + "D D {'weight': 184, 'kind': {'aromatic', 'peptide_bond', 'ionic', 'hbond'}, 'peptide_bond': 143, 'ionic': 31, 'hbond': 6, 'aromatic': 4}\n", + "D M {'weight': 4, 'kind': {'aromatic', 'hbond'}, 'hbond': 1, 'aromatic': 3}\n", + "D E {'weight': 9, 'kind': {'ionic', 'hbond'}, 'ionic': 6, 'hbond': 3}\n", + "D K {'weight': 5, 'kind': {'aromatic', 'ionic', 'hbond'}, 'ionic': 3, 'hbond': 1, 'aromatic': 1}\n", + "D I {'weight': 3, 'kind': {'ionic', 'hbond'}, 'ionic': 2, 'hbond': 1}\n", + "E E {'weight': 129, 'kind': {'aromatic', 'peptide_bond', 'ionic', 'hbond'}, 'peptide_bond': 103, 'ionic': 22, 'aromatic': 2, 'hbond': 2}\n", "E I {'weight': 4, 'kind': {'ionic'}, 'ionic': 4}\n", "E F {'weight': 2, 'kind': {'ionic'}, 'ionic': 2}\n", - "F F {'weight': 108, 'kind': {'aromatic', 'ionic', 'peptide_bond', 'hbond'}, 'peptide_bond': 92, 'ionic': 6, 'hbond': 9, 'aromatic': 1}\n", + "F F {'weight': 108, 'kind': {'peptide_bond', 'ionic', 'aromatic', 'hbond'}, 'peptide_bond': 92, 'ionic': 6, 'hbond': 9, 'aromatic': 1}\n", "F T {'weight': 1, 'kind': {'ionic'}, 'ionic': 1}\n", - "G G {'weight': 92, 'kind': {'aromatic', 'ionic', 'peptide_bond', 'hbond'}, 'peptide_bond': 81, 'ionic': 7, 'aromatic': 3, 'hbond': 1}\n", - "G N {'weight': 2, 'kind': {'hbond', 'aromatic'}, 'hbond': 1, 'aromatic': 1}\n", + "G G {'weight': 92, 'kind': {'aromatic', 'peptide_bond', 'ionic', 'hbond'}, 'peptide_bond': 81, 'ionic': 7, 'aromatic': 3, 'hbond': 1}\n", + "G N {'weight': 2, 'kind': {'aromatic', 'hbond'}, 'hbond': 1, 'aromatic': 1}\n", "G S {'weight': 1, 'kind': {'ionic'}, 'ionic': 1}\n", "G H {'weight': 1, 'kind': {'ionic'}, 'ionic': 1}\n", - "H H {'weight': 103, 'kind': {'aromatic', 'ionic', 'peptide_bond', 'disulfide', 'hbond'}, 'peptide_bond': 74, 'hbond': 8, 'ionic': 13, 'disulfide': 2, 'aromatic': 6}\n", - "I I {'weight': 94, 'kind': {'aromatic', 'ionic', 'peptide_bond', 'hbond'}, 'peptide_bond': 70, 'aromatic': 9, 'ionic': 13, 'hbond': 2}\n", - "J J {'weight': 64, 'kind': {'peptide_bond', 'aromatic', 'ionic'}, 'peptide_bond': 56, 'ionic': 6, 'aromatic': 2}\n", + "H H {'weight': 103, 'kind': {'peptide_bond', 'ionic', 'aromatic', 'disulfide', 'hbond'}, 'peptide_bond': 74, 'hbond': 8, 'ionic': 13, 'disulfide': 2, 'aromatic': 6}\n", + "I I {'weight': 94, 'kind': {'aromatic', 'peptide_bond', 'ionic', 'hbond'}, 'peptide_bond': 70, 'aromatic': 9, 'ionic': 13, 'hbond': 2}\n", + "J J {'weight': 64, 'kind': {'aromatic', 'peptide_bond', 'ionic'}, 'peptide_bond': 56, 'ionic': 6, 'aromatic': 2}\n", "J L {'weight': 1, 'kind': {'aromatic'}, 'aromatic': 1}\n", - "K K {'weight': 57, 'kind': {'aromatic', 'ionic', 'peptide_bond', 'hbond'}, 'peptide_bond': 48, 'hbond': 1, 'ionic': 6, 'aromatic': 2}\n", - "L L {'weight': 52, 'kind': {'aromatic', 'ionic', 'peptide_bond'}, 'peptide_bond': 45, 'aromatic': 3, 'ionic': 4}\n", - "L M {'weight': 3, 'kind': {'hbond', 'aromatic', 'ionic'}, 'ionic': 1, 'aromatic': 1, 'hbond': 1}\n", - "M M {'weight': 46, 'kind': {'peptide_bond', 'aromatic', 'ionic'}, 'peptide_bond': 42, 'ionic': 2, 'aromatic': 2}\n", - "N N {'weight': 584, 'kind': {'aromatic', 'ionic', 'peptide_bond', 'hbond'}, 'peptide_bond': 512, 'hbond': 8, 'ionic': 18, 'aromatic': 46}\n", + "K K {'weight': 57, 'kind': {'peptide_bond', 'ionic', 'aromatic', 'hbond'}, 'peptide_bond': 48, 'hbond': 1, 'ionic': 6, 'aromatic': 2}\n", + "L L {'weight': 52, 'kind': {'aromatic', 'peptide_bond', 'ionic'}, 'aromatic': 3, 'peptide_bond': 45, 'ionic': 4}\n", + "L M {'weight': 3, 'kind': {'aromatic', 'ionic', 'hbond'}, 'ionic': 1, 'aromatic': 1, 'hbond': 1}\n", + "M M {'weight': 46, 'kind': {'aromatic', 'peptide_bond', 'ionic'}, 'peptide_bond': 42, 'ionic': 2, 'aromatic': 2}\n", + "N N {'weight': 584, 'kind': {'peptide_bond', 'ionic', 'aromatic', 'hbond'}, 'peptide_bond': 512, 'ionic': 18, 'hbond': 8, 'aromatic': 46}\n", "N Y {'weight': 6, 'kind': {'aromatic', 'ionic'}, 'ionic': 3, 'aromatic': 3}\n", "N W {'weight': 1, 'kind': {'aromatic'}, 'aromatic': 1}\n", "N O {'weight': 18, 'kind': {'aromatic', 'ionic', 'hbond'}, 'hbond': 6, 'ionic': 10, 'aromatic': 2}\n", "N P {'weight': 8, 'kind': {'aromatic', 'ionic'}, 'ionic': 5, 'aromatic': 3}\n", - "N T {'weight': 2, 'kind': {'hbond', 'ionic'}, 'ionic': 1, 'hbond': 1}\n", - "N Q {'weight': 3, 'kind': {'hbond', 'ionic'}, 'ionic': 2, 'hbond': 1}\n", + "N T {'weight': 2, 'kind': {'ionic', 'hbond'}, 'ionic': 1, 'hbond': 1}\n", + "N Q {'weight': 3, 'kind': {'ionic', 'hbond'}, 'ionic': 2, 'hbond': 1}\n", "N Z {'weight': 2, 'kind': {'ionic'}, 'ionic': 2}\n", - "N S {'weight': 3, 'kind': {'hbond', 'aromatic', 'ionic'}, 'ionic': 1, 'aromatic': 1, 'hbond': 1}\n", - "O O {'weight': 256, 'kind': {'aromatic', 'ionic', 'peptide_bond', 'hbond'}, 'peptide_bond': 225, 'aromatic': 5, 'ionic': 21, 'hbond': 5}\n", + "N S {'weight': 3, 'kind': {'aromatic', 'ionic', 'hbond'}, 'ionic': 1, 'aromatic': 1, 'hbond': 1}\n", + "O O {'weight': 256, 'kind': {'aromatic', 'peptide_bond', 'ionic', 'hbond'}, 'peptide_bond': 225, 'aromatic': 5, 'ionic': 21, 'hbond': 5}\n", "O Q {'weight': 3, 'kind': {'aromatic', 'ionic'}, 'aromatic': 1, 'ionic': 2}\n", - "O V {'weight': 8, 'kind': {'hbond', 'aromatic', 'ionic'}, 'ionic': 3, 'hbond': 1, 'aromatic': 4}\n", + "O V {'weight': 8, 'kind': {'aromatic', 'ionic', 'hbond'}, 'ionic': 3, 'hbond': 1, 'aromatic': 4}\n", "O R {'weight': 2, 'kind': {'ionic'}, 'ionic': 2}\n", - "O U {'weight': 3, 'kind': {'hbond', 'ionic'}, 'hbond': 1, 'ionic': 2}\n", - "P P {'weight': 319, 'kind': {'aromatic', 'ionic', 'peptide_bond', 'hbond'}, 'peptide_bond': 258, 'aromatic': 43, 'ionic': 15, 'hbond': 3}\n", + "O U {'weight': 3, 'kind': {'ionic', 'hbond'}, 'hbond': 1, 'ionic': 2}\n", + "P P {'weight': 319, 'kind': {'aromatic', 'peptide_bond', 'ionic', 'hbond'}, 'peptide_bond': 258, 'aromatic': 43, 'ionic': 15, 'hbond': 3}\n", "P S {'weight': 4, 'kind': {'ionic'}, 'ionic': 4}\n", "P W {'weight': 4, 'kind': {'aromatic', 'ionic'}, 'ionic': 3, 'aromatic': 1}\n", - "P U {'weight': 1, 'kind': {'ionic'}, 'ionic': 1}\n", "P T {'weight': 7, 'kind': {'aromatic', 'ionic'}, 'ionic': 6, 'aromatic': 1}\n", - "Q Q {'weight': 179, 'kind': {'aromatic', 'ionic', 'peptide_bond', 'hbond'}, 'peptide_bond': 143, 'hbond': 4, 'aromatic': 4, 'ionic': 28}\n", + "P U {'weight': 1, 'kind': {'ionic'}, 'ionic': 1}\n", + "Q Q {'weight': 179, 'kind': {'aromatic', 'peptide_bond', 'ionic', 'hbond'}, 'peptide_bond': 143, 'hbond': 4, 'aromatic': 4, 'ionic': 28}\n", "Q S {'weight': 2, 'kind': {'ionic'}, 'ionic': 2}\n", - "Q R {'weight': 10, 'kind': {'hbond', 'ionic'}, 'ionic': 7, 'hbond': 3}\n", - "Q X {'weight': 6, 'kind': {'hbond', 'aromatic', 'ionic'}, 'ionic': 4, 'hbond': 1, 'aromatic': 1}\n", + "Q R {'weight': 10, 'kind': {'ionic', 'hbond'}, 'ionic': 7, 'hbond': 3}\n", + "Q X {'weight': 6, 'kind': {'aromatic', 'ionic', 'hbond'}, 'ionic': 4, 'hbond': 1, 'aromatic': 1}\n", "Q Z {'weight': 3, 'kind': {'aromatic'}, 'aromatic': 3}\n", - "Q V {'weight': 3, 'kind': {'hbond', 'ionic'}, 'hbond': 1, 'ionic': 2}\n", - "R R {'weight': 128, 'kind': {'aromatic', 'ionic', 'peptide_bond', 'hbond'}, 'peptide_bond': 103, 'ionic': 21, 'aromatic': 2, 'hbond': 2}\n", - "R V {'weight': 5, 'kind': {'hbond', 'ionic'}, 'hbond': 1, 'ionic': 4}\n", + "Q V {'weight': 3, 'kind': {'ionic', 'hbond'}, 'ionic': 2, 'hbond': 1}\n", + "R R {'weight': 128, 'kind': {'aromatic', 'peptide_bond', 'ionic', 'hbond'}, 'peptide_bond': 103, 'ionic': 21, 'aromatic': 2, 'hbond': 2}\n", + "R V {'weight': 5, 'kind': {'ionic', 'hbond'}, 'ionic': 4, 'hbond': 1}\n", "R S {'weight': 3, 'kind': {'ionic'}, 'ionic': 3}\n", - "S S {'weight': 107, 'kind': {'aromatic', 'ionic', 'peptide_bond', 'hbond'}, 'peptide_bond': 92, 'ionic': 6, 'hbond': 8, 'aromatic': 1}\n", - "T T {'weight': 93, 'kind': {'aromatic', 'ionic', 'peptide_bond', 'hbond'}, 'peptide_bond': 81, 'ionic': 7, 'aromatic': 4, 'hbond': 1}\n", + "S S {'weight': 107, 'kind': {'peptide_bond', 'ionic', 'aromatic', 'hbond'}, 'peptide_bond': 92, 'ionic': 6, 'hbond': 8, 'aromatic': 1}\n", + "T T {'weight': 93, 'kind': {'aromatic', 'peptide_bond', 'ionic', 'hbond'}, 'peptide_bond': 81, 'ionic': 7, 'aromatic': 4, 'hbond': 1}\n", "T U {'weight': 1, 'kind': {'ionic'}, 'ionic': 1}\n", - "U U {'weight': 100, 'kind': {'aromatic', 'ionic', 'peptide_bond', 'disulfide', 'hbond'}, 'peptide_bond': 74, 'hbond': 6, 'ionic': 12, 'disulfide': 2, 'aromatic': 6}\n", - "V V {'weight': 93, 'kind': {'aromatic', 'ionic', 'peptide_bond', 'hbond'}, 'peptide_bond': 70, 'aromatic': 8, 'ionic': 13, 'hbond': 2}\n", - "W W {'weight': 64, 'kind': {'peptide_bond', 'aromatic', 'ionic'}, 'peptide_bond': 56, 'ionic': 6, 'aromatic': 2}\n", + "U U {'weight': 100, 'kind': {'peptide_bond', 'ionic', 'aromatic', 'disulfide', 'hbond'}, 'peptide_bond': 74, 'hbond': 6, 'ionic': 12, 'disulfide': 2, 'aromatic': 6}\n", + "V V {'weight': 93, 'kind': {'aromatic', 'peptide_bond', 'ionic', 'hbond'}, 'peptide_bond': 70, 'aromatic': 8, 'ionic': 13, 'hbond': 2}\n", + "W W {'weight': 64, 'kind': {'aromatic', 'peptide_bond', 'ionic'}, 'peptide_bond': 56, 'ionic': 6, 'aromatic': 2}\n", "W Y {'weight': 1, 'kind': {'aromatic'}, 'aromatic': 1}\n", - "X X {'weight': 56, 'kind': {'aromatic', 'ionic', 'peptide_bond', 'hbond'}, 'peptide_bond': 48, 'hbond': 1, 'ionic': 5, 'aromatic': 2}\n", - "Y Y {'weight': 52, 'kind': {'aromatic', 'ionic', 'peptide_bond'}, 'peptide_bond': 45, 'aromatic': 3, 'ionic': 4}\n", + "X X {'weight': 56, 'kind': {'peptide_bond', 'ionic', 'aromatic', 'hbond'}, 'peptide_bond': 48, 'hbond': 1, 'ionic': 5, 'aromatic': 2}\n", + "Y Y {'weight': 52, 'kind': {'aromatic', 'peptide_bond', 'ionic'}, 'aromatic': 3, 'peptide_bond': 45, 'ionic': 4}\n", "Y Z {'weight': 2, 'kind': {'aromatic', 'ionic'}, 'ionic': 1, 'aromatic': 1}\n", - "Z Z {'weight': 46, 'kind': {'peptide_bond', 'aromatic', 'ionic'}, 'peptide_bond': 41, 'ionic': 3, 'aromatic': 2}\n" + "Z Z {'weight': 46, 'kind': {'aromatic', 'peptide_bond', 'ionic'}, 'peptide_bond': 41, 'ionic': 3, 'aromatic': 2}\n" ] }, { @@ -28930,9 +29041,6 @@ } ], "metadata": { - "interpreter": { - "hash": "2084dd4fc0c9f9186ef9bb5d9f5c6652432726a285d6ac2dcf2b1a616ab39cbb" - }, "kernelspec": { "display_name": "Python 3.8.12 ('graphein-wip')", "language": "python", @@ -28948,9 +29056,14 @@ "name": "python", "nbconvert_exporter": "python", "pygments_lexer": "ipython3", - "version": "3.8.12" + "version": "3.8.13" }, - "orig_nbformat": 4 + "orig_nbformat": 4, + "vscode": { + "interpreter": { + "hash": "2084dd4fc0c9f9186ef9bb5d9f5c6652432726a285d6ac2dcf2b1a616ab39cbb" + } + } }, "nbformat": 4, "nbformat_minor": 2 diff --git a/notebooks/molecule_model_tutorial_tox.ipynb b/notebooks/molecule_model_tutorial_tox.ipynb new file mode 100644 index 00000000..146bd070 --- /dev/null +++ b/notebooks/molecule_model_tutorial_tox.ipynb @@ -0,0 +1,491 @@ +{ + "cells": [ + { + "cell_type": "markdown", + "metadata": {}, + "source": [ + "# Predicting Acute Toxicity LD50\n", + "\n", + "Here we show a worked example applying graphein to process a [molecule dataset](https://tdcommons.ai/single_pred_tasks/tox/) from [TDC](https://tdcommons.ai/).\n", + "\n", + "**Dataset Description**: Acute toxicity LD50 measures the most conservative dose that can lead to lethal adverse effects. The higher the dose, the more lethal of a drug. This dataset is kindly provided by the authors of [1].\n", + "\n", + "**Task Description**: Regression. Given a drug SMILES string, predict its acute toxicity.\n", + "\n", + "**Dataset Statistics**: 7,385 drugs.\n", + "\n", + "**Dataset Split**: Random Split Scaffold Split\n", + "\n", + "[1] Zhu, Hao, et al. “Quantitative structure− activity relationship modeling of rat acute toxicity by oral exposure.” Chemical research in toxicology 22.12 (2009): 1913-1921.\n", + "\n", + "[![Open In Colab](https://colab.research.google.com/assets/colab-badge.svg)](https://colab.research.google.com/github/a-r-j/graphein/blob/master/notebooks/molecule_model_tutorial_tox.ipynb) [![GitHub](https://img.shields.io/badge/-View%20on%20GitHub-181717?logo=github&logoColor=ffffff)](https://github.com/a-r-j/graphein/blob/master/notebooks/molecule_model_tutorial_tox.ipynb)" + ] + }, + { + "cell_type": "code", + "execution_count": 42, + "metadata": {}, + "outputs": [], + "source": [ + "# Install Graphein if necessary\n", + "# !pip install graphein[extras]\n", + "\n", + "# Install TDC if necessary\n", + "# !pip install PyTDC\n", + "\n", + "# NB you may need to install DL libraries such as pytorch, pytorch-lightning and torch-geometric\n", + "# These are left to the user to configure as they depend on your particular desired configuration (e.g CUDA)" + ] + }, + { + "cell_type": "code", + "execution_count": null, + "metadata": {}, + "outputs": [], + "source": [ + "# NBVAL_SKIP\n", + "from tdc.single_pred import Tox" + ] + }, + { + "cell_type": "code", + "execution_count": 43, + "metadata": {}, + "outputs": [ + { + "name": "stderr", + "output_type": "stream", + "text": [ + "Found local copy...\n", + "Loading...\n", + "Done!\n" + ] + }, + { + "data": { + "text/html": [ + "
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Drug_IDDrugY
0Methane, tribromo-BrC(Br)Br2.343
1Bromoethene (9CI)C=CBr2.330
21,1'-Biphenyl, hexabromo-Brc1ccc(-c2ccc(Br)c(Br)c2Br)c(Br)c1Br1.465
3Isothiocyanic acid, p-bromophenyl esterS=C=Nc1ccc(Br)cc12.729
4Benzene, bromo-Brc1ccccc11.765
\n", + "
" + ], + "text/plain": [ + " Drug_ID \\\n", + "0 Methane, tribromo- \n", + "1 Bromoethene (9CI) \n", + "2 1,1'-Biphenyl, hexabromo- \n", + "3 Isothiocyanic acid, p-bromophenyl ester \n", + "4 Benzene, bromo- \n", + "\n", + " Drug Y \n", + "0 BrC(Br)Br 2.343 \n", + "1 C=CBr 2.330 \n", + "2 Brc1ccc(-c2ccc(Br)c(Br)c2Br)c(Br)c1Br 1.465 \n", + "3 S=C=Nc1ccc(Br)cc1 2.729 \n", + "4 Brc1ccccc1 1.765 " + ] + }, + "execution_count": 43, + "metadata": {}, + "output_type": "execute_result" + } + ], + "source": [ + "# NBVAL_SKIP\n", + "# Load data\n", + "data = Tox(name = 'LD50_Zhu')\n", + "split = data.get_split()\n", + "split[\"train\"].head()" + ] + }, + { + "cell_type": "markdown", + "metadata": {}, + "source": [ + "## Creating Molecular Graphs with Graphein" + ] + }, + { + "cell_type": "code", + "execution_count": 44, + "metadata": {}, + "outputs": [], + "source": [ + "# NBVAL_SKIP\n", + "import torch\n", + "import graphein.molecule as gm\n", + "import graphein.ml as ml" + ] + }, + { + "cell_type": "code", + "execution_count": 45, + "metadata": {}, + "outputs": [ + { + "name": "stdout", + "output_type": "stream", + "text": [ + " \r" + ] + } + ], + "source": [ + "# NBVAL_SKIP\n", + "config = gm.MoleculeGraphConfig()\n", + "\n", + "# Iterate over dataframes containing each split\n", + "train_graphs = [gm.construct_graph(smiles=smiles, config=config) for smiles in split[\"train\"][\"Drug\"]]\n", + "valid_graphs = [gm.construct_graph(smiles=smiles, config=config) for smiles in split[\"valid\"][\"Drug\"]]\n", + "test_graphs = [gm.construct_graph(smiles=smiles, config=config) for smiles in split[\"test\"][\"Drug\"]]\n", + "\n", + "# Assign labels to graphs\n", + "train_graphs = ml.add_labels_to_graph(train_graphs, labels=split[\"train\"][\"Y\"].apply(torch.tensor), name=\"graph_label\")\n", + "valid_graphs = ml.add_labels_to_graph(valid_graphs, labels=split[\"valid\"][\"Y\"].apply(torch.tensor), name=\"graph_label\")\n", + "test_graphs = ml.add_labels_to_graph(test_graphs, labels=split[\"test\"][\"Y\"].apply(torch.tensor), name=\"graph_label\")" + ] + }, + { + "cell_type": "code", + "execution_count": 46, + "metadata": {}, + "outputs": [], + "source": [ + "# NBVAL_SKIP\n", + "from graphein.ml import GraphFormatConvertor\n", + "from torch_geometric.loader import DataLoader\n", + "\n", + "# Define a conversion object\n", + "convertor = GraphFormatConvertor(\n", + " src_format=\"nx\",\n", + " dst_format=\"pyg\",\n", + " columns=[\"edge_index\", \"atom_type_one_hot\", \"graph_label\"]\n", + " )\n", + "\n", + "# Convert Graphs from NX to PyG\n", + "train_graphs = [convertor(g) for g in train_graphs]\n", + "valid_graphs = [convertor(g) for g in valid_graphs]\n", + "test_graphs = [convertor(g) for g in test_graphs]\n", + "\n", + "# Create Dataloaders\n", + "train_loader = DataLoader(train_graphs, batch_size=32, shuffle=True)\n", + "valid_loader = DataLoader(valid_graphs, batch_size=32, shuffle=False)\n", + "test_loader = DataLoader(test_graphs, shuffle=False)" + ] + }, + { + "cell_type": "code", + "execution_count": 49, + "metadata": {}, + "outputs": [ + { + "name": "stdout", + "output_type": "stream", + "text": [ + "DataBatch(edge_index=[2, 546], node_id=[32], atom_type_one_hot=[529, 11], graph_label=[32], num_nodes=529, batch=[529], ptr=[33])\n" + ] + } + ], + "source": [ + "# NBVAL_SKIP\n", + "# Inspect a batch\n", + "for i in train_loader:\n", + " print(i)\n", + " break" + ] + }, + { + "cell_type": "markdown", + "metadata": {}, + "source": [ + "## Define Model" + ] + }, + { + "cell_type": "code", + "execution_count": 50, + "metadata": {}, + "outputs": [], + "source": [ + "# NBVAL_SKIP\n", + "from torch_geometric.nn import GCNConv, global_add_pool\n", + "from torch.nn.functional import mse_loss\n", + "from torch.nn import functional as F\n", + "import torch.nn as nn\n", + "import pytorch_lightning as pl" + ] + }, + { + "cell_type": "code", + "execution_count": 51, + "metadata": {}, + "outputs": [], + "source": [ + "# NBVAL_SKIP\n", + "config_default = dict(\n", + " n_hid = 8,\n", + " n_out = 8,\n", + " batch_size = 4,\n", + " dropout = 0.5,\n", + " lr = 0.001,\n", + " num_heads = 32,\n", + " num_att_dim = 64,\n", + " model_name = 'GCN'\n", + ")\n", + "\n", + "class Struct:\n", + " def __init__(self, **entries):\n", + " self.__dict__.update(entries)\n", + "\n", + "config = Struct(**config_default)\n", + "\n", + "global model_name\n", + "model_name = config.model_name" + ] + }, + { + "cell_type": "code", + "execution_count": 52, + "metadata": {}, + "outputs": [], + "source": [ + "# NBVAL_SKIP\n", + "class GraphNets(pl.LightningModule):\n", + " def __init__(self):\n", + " super().__init__()\n", + "\n", + " self.layer1 = GCNConv(in_channels=11, out_channels=config.n_hid)\n", + " self.layer2 = GCNConv(in_channels=config.n_hid, out_channels=config.n_out)\n", + " self.decoder = nn.Linear(config.n_out, 1)\n", + "\n", + " def forward(self, g):\n", + " x = g.atom_type_one_hot.float()\n", + " x = F.dropout(x, p=config.dropout, training=self.training)\n", + " x = F.elu(self.layer1(x, g.edge_index))\n", + " x = F.dropout(x, p=config.dropout, training=self.training)\n", + " x = self.layer2(x, g.edge_index)\n", + " x = global_add_pool(x, batch=g.batch)\n", + " x = self.decoder(x)\n", + " return x\n", + "\n", + " def training_step(self, batch, batch_idx):\n", + " x = batch\n", + " y = x.graph_label\n", + " y_hat = self(x)\n", + " loss = mse_loss(y_hat, y)\n", + "\n", + " self.log(\"train_loss\", loss)\n", + " return loss\n", + "\n", + " def validation_step(self, batch, batch_idx):\n", + " x = batch\n", + " y = x.graph_label\n", + " y_hat = self(x)\n", + " loss = mse_loss(y_hat, y)\n", + " self.log(\"valid_loss\", loss)\n", + "\n", + " def test_step(self, batch, batch_idx):\n", + " x = batch\n", + " y = x.graph_label\n", + " y_hat = self(x)\n", + " loss = mse_loss(y_hat, y)\n", + "\n", + " self.log(\"test_loss\", loss)\n", + "\n", + " def configure_optimizers(self):\n", + " return torch.optim.Adam(self.parameters(), lr=config.lr)" + ] + }, + { + "cell_type": "markdown", + "metadata": {}, + "source": [ + "## Train!" + ] + }, + { + "cell_type": "code", + "execution_count": 53, + "metadata": {}, + "outputs": [ + { + "name": "stderr", + "output_type": "stream", + "text": [ + "GPU available: True, used: True\n", + "TPU available: False, using: 0 TPU cores\n", + "IPU available: False, using: 0 IPUs\n", + "HPU available: False, using: 0 HPUs\n", + "LOCAL_RANK: 0 - CUDA_VISIBLE_DEVICES: [0,1]\n", + "\n", + " | Name | Type | Params\n", + "------------------------------------\n", + "0 | layer1 | GCNConv | 96 \n", + "1 | layer2 | GCNConv | 72 \n", + "2 | decoder | Linear | 9 \n", + "------------------------------------\n", + "177 Trainable params\n", + "0 Non-trainable params\n", + "177 Total params\n", + "0.001 Total estimated model params size (MB)\n" + ] + }, + { + "name": "stdout", + "output_type": "stream", + "text": [ + "Epoch 49: 100%|██████████| 186/186 [00:01<00:00, 179.13it/s, loss=0.932, v_num=2]\n" + ] + } + ], + "source": [ + "# NBVAL_SKIP\n", + "model = GraphNets()\n", + "\n", + "trainer = pl.Trainer(max_epochs=50, gpus=1, strategy=None)\n", + "trainer.fit(model, train_loader, valid_loader)" + ] + }, + { + "cell_type": "markdown", + "metadata": {}, + "source": [ + "## Test" + ] + }, + { + "cell_type": "code", + "execution_count": 58, + "metadata": {}, + "outputs": [ + { + "name": "stderr", + "output_type": "stream", + "text": [ + "LOCAL_RANK: 0 - CUDA_VISIBLE_DEVICES: [0,1]\n" + ] + }, + { + "name": "stdout", + "output_type": "stream", + "text": [ + "Testing DataLoader 0: 100%|██████████| 1477/1477 [00:03<00:00, 443.90it/s]\n" + ] + }, + { + "data": { + "text/html": [ + "
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╭───────────────── <class 'graphein.molecule.config.MoleculeGraphConfig'> ──────────────────╮\n",
-       " Config Object for Molecule Structure Graph Construction.                                  \n",
-       "                                                                                           \n",
-       " ╭───────────────────────────────────────────────────────────────────────────────────────╮ \n",
-       "  MoleculeGraphConfig(verbose=False, add_hs=False, generate_conformer=False,             \n",
-       "  edge_construction_functions=[<function add_fully_connected_edges at 0x7f10c593f9d0>,   \n",
-       "  <function add_k_nn_edges at 0x7f10c593fa60>, <function add_distance_threshold at       \n",
-       "  0x7f10c593f940>, <function add_atom_bonds at 0x7f10c593f550>],                         \n",
-       "  node_metadata_functions=[<function atom_type_one_hot at 0x7f10c56e1f70>],              \n",
-       "  edge_metadata_functions=None, graph_metadata_functions=None)                           \n",
-       " ╰───────────────────────────────────────────────────────────────────────────────────────╯ \n",
-       "                                                                                           \n",
-       "                      add_hs = False                                                       \n",
-       " edge_construction_functions = [                                                           \n",
-       "                                   <function add_fully_connected_edges at 0x7f10c593f9d0>, \n",
-       "                                   <function add_k_nn_edges at 0x7f10c593fa60>,            \n",
-       "                                   <function add_distance_threshold at 0x7f10c593f940>,    \n",
-       "                                   <function add_atom_bonds at 0x7f10c593f550>             \n",
-       "                               ]                                                           \n",
-       "     edge_metadata_functions = None                                                        \n",
-       "          generate_conformer = False                                                       \n",
-       "    graph_metadata_functions = None                                                        \n",
-       "     node_metadata_functions = [<function atom_type_one_hot at 0x7f10c56e1f70>]            \n",
-       "                     verbose = False                                                       \n",
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"\u001b[34m│\u001b[0m \u001b[32m│\u001b[0m \u001b[1m<\u001b[0m\u001b[1;95mfunction\u001b[0m\u001b[39m add_k_nn_edges at \u001b[0m\u001b[1;36m0x7f10c593fa60\u001b[0m\u001b[1m>\u001b[0m, \u001b[1m<\u001b[0m\u001b[1;95mfunction\u001b[0m\u001b[39m add_distance_threshold at \u001b[0m \u001b[32m│\u001b[0m \u001b[34m│\u001b[0m\n", - "\u001b[34m│\u001b[0m \u001b[32m│\u001b[0m \u001b[1;36m0x7f10c593f940\u001b[0m\u001b[1m>\u001b[0m, \u001b[1m<\u001b[0m\u001b[1;95mfunction\u001b[0m\u001b[39m add_atom_bonds at \u001b[0m\u001b[1;36m0x7f10c593f550\u001b[0m\u001b[1m>\u001b[0m\u001b[1m]\u001b[0m, \u001b[32m│\u001b[0m \u001b[34m│\u001b[0m\n", - "\u001b[34m│\u001b[0m \u001b[32m│\u001b[0m \u001b[33mnode_metadata_functions\u001b[0m=\u001b[1m[\u001b[0m\u001b[1m<\u001b[0m\u001b[1;95mfunction\u001b[0m\u001b[39m atom_type_one_hot at \u001b[0m\u001b[1;36m0x7f10c56e1f70\u001b[0m\u001b[1m>\u001b[0m\u001b[1m]\u001b[0m, \u001b[32m│\u001b[0m \u001b[34m│\u001b[0m\n", - "\u001b[34m│\u001b[0m \u001b[32m│\u001b[0m \u001b[33medge_metadata_functions\u001b[0m=\u001b[3;35mNone\u001b[0m, \u001b[33mgraph_metadata_functions\u001b[0m=\u001b[3;35mNone\u001b[0m\u001b[1m)\u001b[0m \u001b[32m│\u001b[0m \u001b[34m│\u001b[0m\n", - "\u001b[34m│\u001b[0m \u001b[32m╰───────────────────────────────────────────────────────────────────────────────────────╯\u001b[0m \u001b[34m│\u001b[0m\n", - "\u001b[34m│\u001b[0m \u001b[34m│\u001b[0m\n", - "\u001b[34m│\u001b[0m \u001b[3;33madd_hs\u001b[0m = \u001b[3;91mFalse\u001b[0m \u001b[34m│\u001b[0m\n", - "\u001b[34m│\u001b[0m \u001b[3;33medge_construction_functions\u001b[0m = \u001b[1m[\u001b[0m \u001b[34m│\u001b[0m\n", - "\u001b[34m│\u001b[0m \u001b[1m<\u001b[0m\u001b[1;95mfunction\u001b[0m\u001b[39m add_fully_connected_edges at \u001b[0m\u001b[1;36m0x7f10c593f9d0\u001b[0m\u001b[1m>\u001b[0m, \u001b[34m│\u001b[0m\n", - "\u001b[34m│\u001b[0m \u001b[1m<\u001b[0m\u001b[1;95mfunction\u001b[0m\u001b[39m add_k_nn_edges at \u001b[0m\u001b[1;36m0x7f10c593fa60\u001b[0m\u001b[1m>\u001b[0m, \u001b[34m│\u001b[0m\n", - "\u001b[34m│\u001b[0m \u001b[1m<\u001b[0m\u001b[1;95mfunction\u001b[0m\u001b[39m add_distance_threshold at \u001b[0m\u001b[1;36m0x7f10c593f940\u001b[0m\u001b[1m>\u001b[0m, \u001b[34m│\u001b[0m\n", - "\u001b[34m│\u001b[0m \u001b[1m<\u001b[0m\u001b[1;95mfunction\u001b[0m\u001b[39m add_atom_bonds at \u001b[0m\u001b[1;36m0x7f10c593f550\u001b[0m\u001b[1m>\u001b[0m \u001b[34m│\u001b[0m\n", - "\u001b[34m│\u001b[0m \u001b[1m]\u001b[0m \u001b[34m│\u001b[0m\n", - "\u001b[34m│\u001b[0m \u001b[3;33medge_metadata_functions\u001b[0m = \u001b[3;35mNone\u001b[0m \u001b[34m│\u001b[0m\n", - "\u001b[34m│\u001b[0m \u001b[3;33mgenerate_conformer\u001b[0m = \u001b[3;91mFalse\u001b[0m \u001b[34m│\u001b[0m\n", - "\u001b[34m│\u001b[0m \u001b[3;33mgraph_metadata_functions\u001b[0m = \u001b[3;35mNone\u001b[0m \u001b[34m│\u001b[0m\n", - "\u001b[34m│\u001b[0m \u001b[3;33mnode_metadata_functions\u001b[0m = \u001b[1m[\u001b[0m\u001b[1m<\u001b[0m\u001b[1;95mfunction\u001b[0m\u001b[39m atom_type_one_hot at \u001b[0m\u001b[1;36m0x7f10c56e1f70\u001b[0m\u001b[1m>\u001b[0m\u001b[1m]\u001b[0m \u001b[34m│\u001b[0m\n", - "\u001b[34m│\u001b[0m \u001b[3;33mverbose\u001b[0m = \u001b[3;91mFalse\u001b[0m \u001b[34m│\u001b[0m\n", - "\u001b[34m╰───────────────────────────────────────────────────────────────────────────────────────────╯\u001b[0m\n" - ] - }, - "metadata": {}, - "output_type": "display_data" - } - ], - "source": [ - "config = gm.MoleculeGraphConfig()\n", - "inspect(config)" - ] - }, - { - "cell_type": "markdown", - "metadata": {}, - "source": [ - "## Creating Graphs\n", - "\n", - "### Creating a Molecular Graph from SMILES\n", - "\n", - "Let's take a look at a simple molecule, acetylsalicylic acid (or aspirin as it's more commonly known)." - ] - }, - { - "cell_type": "code", - "execution_count": 7, - "metadata": {}, - "outputs": [ - { - "data": { - "text/html": [ - "
Graph named 'CC(=O)OC1=CC=CC=C1C(=O)O' with 13 nodes and 13 edges\n",
-       "
\n" - ], - "text/plain": [ - "Graph named \u001b[32m'CC\u001b[0m\u001b[32m(\u001b[0m\u001b[32m=O\u001b[0m\u001b[32m)\u001b[0m\u001b[32mOC1\u001b[0m\u001b[32m=\u001b[0m\u001b[32mCC\u001b[0m\u001b[32m=\u001b[0m\u001b[32mCC\u001b[0m\u001b[32m=\u001b[0m\u001b[32mC1C\u001b[0m\u001b[32m(\u001b[0m\u001b[32m=O\u001b[0m\u001b[32m)\u001b[0m\u001b[32mO'\u001b[0m with \u001b[1;36m13\u001b[0m nodes and \u001b[1;36m13\u001b[0m edges\n" - ] - }, - "metadata": {}, - "output_type": "display_data" - }, - { - "data": { - "image/png": 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- "text/plain": [ - "
" - ] - }, - "metadata": {}, - "output_type": "display_data" - } - ], - "source": [ - "graph = gm.construct_graph(smiles=\"CC(=O)OC1=CC=CC=C1C(=O)O\", config=config)\n", - "print(graph)\n", - "nx.draw(graph)\n", - "graph.graph[\"rdmol\"]" - ] - }, - { - "cell_type": "markdown", - "metadata": {}, - "source": [ - "Molecule features are stored as dictionaries on the graph, nodes and edges." - ] - }, - { - "cell_type": "code", - "execution_count": 8, - "metadata": {}, - "outputs": [ - { - "data": { - "text/html": [ - "
{\n",
-       "    'atomic_num': 6,\n",
-       "    'element': 'C',\n",
-       "    'rdmol_atom': <rdkit.Chem.rdchem.Atom object at 0x7f10c5030460>,\n",
-       "    'coords': None,\n",
-       "    'atom_type_one_hot': array([1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0])\n",
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{'kind': {'bond'}, 'bond': <rdkit.Chem.rdchem.Bond object at 0x7f10c5048220>}\n",
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Graph named 'long_test' with 20 nodes and 21 edges\n",
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Under the hood, we wrap [RDKit](https://www.rdkit.org/) functions for the graph construction. While the main format used is a [NetworkX](https://networkx.org/) `nx.Graph`, each graph, node & edge has its underlying [RDKit object](https://www.rdkit.org/docs/source/rdkit.Chem.rdchem.html) stored as metadata so RDKit methods can still be used.\n", + "\n", + "[![Open In Colab](https://colab.research.google.com/assets/colab-badge.svg)](https://colab.research.google.com/github/a-r-j/graphein/blob/master/notebooks/molecule_tutorial.ipynb) [![GitHub](https://img.shields.io/badge/-View%20on%20GitHub-181717?logo=github&logoColor=ffffff)](https://github.com/a-r-j/graphein/blob/master/notebooks/molecule_tutorial.ipynb)" + ] }, - "autotypenumbers": "strict", - "coloraxis": { - "colorbar": { - "outlinewidth": 0, - "ticks": "" - } + { + "cell_type": "code", + "execution_count": 4, + "metadata": {}, + "outputs": [], + "source": [ + "# Install Graphein if necessary\n", + "# !pip install graphein[extras]" + ] }, - "colorscale": { - "diverging": [ - [ - 0, - "#8e0152" - ], - [ - 0.1, - "#c51b7d" - ], - [ - 0.2, - "#de77ae" - ], - [ - 0.3, - "#f1b6da" - ], - [ - 0.4, - "#fde0ef" - ], - [ - 0.5, - "#f7f7f7" - ], - [ - 0.6, - "#e6f5d0" - ], - [ - 0.7, - "#b8e186" - ], - [ - 0.8, - "#7fbc41" - ], - [ - 0.9, - "#4d9221" - ], - [ - 1, - "#276419" - ] - ], - "sequential": [ - [ - 0, - "#0d0887" - ], - [ - 0.1111111111111111, - "#46039f" - ], - [ - 0.2222222222222222, - "#7201a8" - ], - [ - 0.3333333333333333, - "#9c179e" - ], - [ - 0.4444444444444444, - "#bd3786" - ], - [ - 0.5555555555555556, - "#d8576b" - ], - [ - 0.6666666666666666, - "#ed7953" - ], - [ - 0.7777777777777778, - "#fb9f3a" - ], - [ - 0.8888888888888888, - "#fdca26" - ], - [ - 1, - "#f0f921" - ] - ], - "sequentialminus": [ - [ - 0, - "#0d0887" - ], - [ - 0.1111111111111111, - "#46039f" - ], - [ - 0.2222222222222222, - "#7201a8" - ], - [ - 0.3333333333333333, - "#9c179e" - ], - [ - 0.4444444444444444, - "#bd3786" - ], - [ - 0.5555555555555556, - "#d8576b" - ], - [ - 0.6666666666666666, - "#ed7953" - ], - [ - 0.7777777777777778, - "#fb9f3a" - ], - [ - 0.8888888888888888, - "#fdca26" - ], - [ - 1, - "#f0f921" - ] - ] + { + "cell_type": "code", + "execution_count": 5, + "metadata": {}, + "outputs": [ + { + "name": "stderr", + "output_type": "stream", + "text": [ + "RDKit WARNING: [14:28:33] Enabling RDKit 2019.09.3 jupyter extensions\n", + "[14:28:33] Enabling RDKit 2019.09.3 jupyter extensions\n" + ] + } + ], + "source": [ + "import networkx as nx\n", + "import logging\n", + "from rich import inspect, print\n", + "logging.getLogger(\"matplotlib\").setLevel(logging.WARNING)\n", + "\n", + "import graphein.molecule as gm" + ] }, - "colorway": [ - "#636efa", - "#EF553B", - "#00cc96", - "#ab63fa", - "#FFA15A", - "#19d3f3", - "#FF6692", - "#B6E880", - "#FF97FF", - "#FECB52" - ], - "font": { - "color": "#2a3f5f" + { + "cell_type": "markdown", + "metadata": {}, + "source": [ + "## Config\n", + "Similar to [Protein Graph Construction](https://graphein.ai/notebooks/residue_graphs.html), configuration of small molecule graphs is controlled by a [`MoleculeGraphConfig`]() object." + ] }, - "geo": { - "bgcolor": "white", - "lakecolor": "white", - "landcolor": "#E5ECF6", - "showlakes": true, - "showland": true, - "subunitcolor": "white" + { + "cell_type": "code", + "execution_count": 6, + "metadata": {}, + "outputs": [ + { + "data": { + "text/html": [ + "
╭───────────────── <class 'graphein.molecule.config.MoleculeGraphConfig'> ──────────────────╮\n",
+                                   " Config Object for Molecule Structure Graph Construction.                                  \n",
+                                   "                                                                                           \n",
+                                   " ╭───────────────────────────────────────────────────────────────────────────────────────╮ \n",
+                                   "  MoleculeGraphConfig(verbose=False, add_hs=False, generate_conformer=False,             \n",
+                                   "  edge_construction_functions=[<function add_fully_connected_edges at 0x7f10c593f9d0>,   \n",
+                                   "  <function add_k_nn_edges at 0x7f10c593fa60>, <function add_distance_threshold at       \n",
+                                   "  0x7f10c593f940>, <function add_atom_bonds at 0x7f10c593f550>],                         \n",
+                                   "  node_metadata_functions=[<function atom_type_one_hot at 0x7f10c56e1f70>],              \n",
+                                   "  edge_metadata_functions=None, graph_metadata_functions=None)                           \n",
+                                   " ╰───────────────────────────────────────────────────────────────────────────────────────╯ \n",
+                                   "                                                                                           \n",
+                                   "                      add_hs = False                                                       \n",
+                                   " edge_construction_functions = [                                                           \n",
+                                   "                                   <function add_fully_connected_edges at 0x7f10c593f9d0>, \n",
+                                   "                                   <function add_k_nn_edges at 0x7f10c593fa60>,            \n",
+                                   "                                   <function add_distance_threshold at 0x7f10c593f940>,    \n",
+                                   "                                   <function add_atom_bonds at 0x7f10c593f550>             \n",
+                                   "                               ]                                                           \n",
+                                   "     edge_metadata_functions = None                                                        \n",
+                                   "          generate_conformer = False                                                       \n",
+                                   "    graph_metadata_functions = None                                                        \n",
+                                   "     node_metadata_functions = [<function atom_type_one_hot at 0x7f10c56e1f70>]            \n",
+                                   "                     verbose = False                                                       \n",
+                                   "╰───────────────────────────────────────────────────────────────────────────────────────────╯\n",
+                                   "
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"hoverlabel": { - "align": "left" + { + "cell_type": "markdown", + "metadata": {}, + "source": [ + "## Creating Graphs\n", + "\n", + "### Creating a Molecular Graph from SMILES\n", + "\n", + "Let's take a look at a simple molecule, acetylsalicylic acid (or aspirin as it's more commonly known)." + ] }, - "hovermode": "closest", - "mapbox": { - "style": "light" + { + "cell_type": "code", + "execution_count": 7, + "metadata": {}, + "outputs": [ + { + "data": { + "text/html": [ + "
Graph named 'CC(=O)OC1=CC=CC=C1C(=O)O' with 13 nodes and 13 edges\n",
+                                   "
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", + "text/plain": [ + "
" + ] + }, + "metadata": {}, + "output_type": "display_data" + } + ], + "source": [ + "graph = gm.construct_graph(smiles=\"CC(=O)OC1=CC=CC=C1C(=O)O\", config=config)\n", + "print(graph)\n", + "nx.draw(graph)\n", + "graph.graph[\"rdmol\"]" + ] }, - "paper_bgcolor": "white", - "plot_bgcolor": "#E5ECF6", - "polar": { - "angularaxis": { - "gridcolor": "white", - "linecolor": "white", - "ticks": "" - }, - "bgcolor": "#E5ECF6", - "radialaxis": { - "gridcolor": "white", - "linecolor": "white", - "ticks": "" - } + { + "cell_type": "markdown", + "metadata": {}, + "source": [ + "Molecule features are stored as dictionaries on the graph, nodes and edges." + ] }, - "scene": { - "xaxis": { - "backgroundcolor": "#E5ECF6", - "gridcolor": "white", - "gridwidth": 2, - "linecolor": "white", - "showbackground": true, - "ticks": "", - "zerolinecolor": "white" - }, - "yaxis": { - "backgroundcolor": "#E5ECF6", - "gridcolor": "white", - "gridwidth": 2, - "linecolor": "white", - "showbackground": true, - "ticks": "", - "zerolinecolor": "white" - }, - "zaxis": { - "backgroundcolor": "#E5ECF6", - "gridcolor": "white", - "gridwidth": 2, - "linecolor": "white", - "showbackground": true, - "ticks": "", - "zerolinecolor": "white" - } + { + "cell_type": "code", + "execution_count": 8, + "metadata": {}, + "outputs": [ + { + "data": { + "text/html": [ + "
{\n",
+                                   "    'atomic_num': 6,\n",
+                                   "    'element': 'C',\n",
+                                   "    'rdmol_atom': <rdkit.Chem.rdchem.Atom object at 0x7f10c5030460>,\n",
+                                   "    'coords': None,\n",
+                                   "    'atom_type_one_hot': array([1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0])\n",
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{\n",
+                                   "    'atomic_num': 8,\n",
+                                   "    'element': 'O',\n",
+                                   "    'rdmol_atom': <rdkit.Chem.rdchem.Atom object at 0x7f10c5030880>,\n",
+                                   "    'coords': None,\n",
+                                   "    'atom_type_one_hot': array([0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0])\n",
+                                   "}\n",
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{\n",
+                                   "    'atomic_num': 8,\n",
+                                   "    'element': 'O',\n",
+                                   "    'rdmol_atom': <rdkit.Chem.rdchem.Atom object at 0x7f10c50308e0>,\n",
+                                   "    'coords': None,\n",
+                                   "    'atom_type_one_hot': array([0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0])\n",
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{'kind': {'bond'}, 'bond': <rdkit.Chem.rdchem.Bond object at 0x7f10c5048100>}\n",
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{'kind': {'bond'}, 'bond': <rdkit.Chem.rdchem.Bond object at 0x7f10c5048160>}\n",
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{'kind': {'bond'}, 'bond': <rdkit.Chem.rdchem.Bond object at 0x7f10c5048220>}\n",
+                                   "
\n" + ], + "text/plain": [ + "\u001b[1m{\u001b[0m\u001b[32m'kind'\u001b[0m: \u001b[1m{\u001b[0m\u001b[32m'bond'\u001b[0m\u001b[1m}\u001b[0m, \u001b[32m'bond'\u001b[0m: \u001b[1m<\u001b[0m\u001b[1;95mrdkit.Chem.rdchem.Bond\u001b[0m\u001b[39m object at \u001b[0m\u001b[1;36m0x7f10c5048220\u001b[0m\u001b[1m>\u001b[0m\u001b[1m}\u001b[0m\n" + ] + }, + "metadata": {}, + "output_type": "display_data" + } + ], + "source": [ + "# Edge metadata\n", + "for u, v, d in graph.edges(data=True):\n", + " print(d)" + ] }, - "ternary": { - "aaxis": { - "gridcolor": "white", - "linecolor": "white", - "ticks": "" - }, - "baxis": { - "gridcolor": "white", - "linecolor": "white", - "ticks": "" - }, - "bgcolor": "#E5ECF6", - "caxis": { - "gridcolor": "white", - "linecolor": "white", - "ticks": "" - } - }, - "title": { - "x": 0.05 - }, - "xaxis": { - "automargin": true, - "gridcolor": "white", - "linecolor": "white", - "ticks": "", - "title": { - "standoff": 15 - }, - "zerolinecolor": "white", - "zerolinewidth": 2 - }, - "yaxis": { - "automargin": true, - "gridcolor": "white", - "linecolor": "white", - "ticks": "", - "title": { - "standoff": 15 - }, - "zerolinecolor": "white", - "zerolinewidth": 2 - } - } - }, - "width": 620 - } - } - }, - "metadata": {}, - "output_type": "display_data" - } - ], - "source": [ - "gm.plotly_molecular_graph(graph)" - ] - }, - { - "cell_type": "markdown", - "metadata": {}, - "source": [ - "### Creating a Molecular Graph from a Mol2 File" - ] - }, - { - "cell_type": "code", - "execution_count": 12, - "metadata": {}, - "outputs": [ - { - "data": { - "text/html": [ - "
Graph named 'short_test' with 3 nodes and 2 edges\n",
-       "
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"text/plain": [ - "" - ] - }, - "execution_count": 12, - "metadata": {}, - "output_type": "execute_result" - } - ], - "source": [ - "graph = gm.construct_graph(path=\"../tests/molecule/test_data/short_test.mol2\", config=config)\n", - "print(graph)\n", - "graph.graph[\"rdmol\"]" - ] - }, - { - "cell_type": "code", - "execution_count": 13, - "metadata": {}, - "outputs": [ - { - "data": { - "application/vnd.plotly.v1+json": { - "config": { - "plotlyServerURL": "https://plot.ly" - }, - "data": [ - { - "hoverinfo": "text+x+y+z", - "marker": { - "color": [ - [ - 0.050383, - 0.029803, - 0.527975, - 1 - ], - [ - 0.050383, - 0.029803, - 0.527975, - 1 - ], - [ - 0.798216, - 0.280197, - 0.469538, - 1 - ] - ], - "opacity": 0.7, - "size": [ - 21, - 22, - 21 - ], - "symbol": "circle" - }, - "mode": "markers", - "text": [ - "C:0", - "C:1", - "N:2" - ], - "type": "scatter3d", - "x": [ - 0.9862, - -0.2052, - -1.4201 - ], - "y": [ - -0.257, - 0.2236, - 0.2357 - ], - "z": [ - -0.1905, - 0.6206, - -0.1847 - ] - }, - { - "hoverinfo": "text", - "line": { - "color": [ - [ - 0.050383, - 0.029803, - 0.527975, - 1 - ], - [ - 0.050383, - 0.029803, - 0.527975, - 1 - ], - [ - 0.050383, - 0.029803, - 0.527975, - 1 - ], - [ - 0.050383, - 0.029803, - 0.527975, - 1 - ], - [ - 0.050383, - 0.029803, - 0.527975, - 1 - ], - [ - 0.050383, - 0.029803, - 0.527975, - 1 - ] - ], - "width": 10 - }, - "mode": "lines", - "text": [ - "bond", - "bond", - "bond", - "bond", - "bond", - "bond" - ], - "type": "scatter3d", - "x": [ - 0.9862, - -0.2052, - null, - -0.2052, - -1.4201, - null - ], - "y": [ - -0.257, - 0.2236, - null, - 0.2236, - 0.2357, - null - ], - "z": [ - -0.1905, - 0.6206, - null, - 0.6206, - -0.1847, - null - ] - } - ], - "layout": { - "height": 650, - "margin": { - "t": 100 - }, - "scene": { - "xaxis": { - "showbackground": false, - "showgrid": false, - "showline": false, - "showticklabels": false, - "title": { - "text": "" + { + "cell_type": "markdown", + "metadata": {}, + "source": [ + "### Creating a Molecular Graph from an SDF File\n", + "\n", + "As SDFs & Mol2 files provide coordinates, we can draw the graph in 3D." + ] }, - "zeroline": false - }, - "yaxis": { - "showbackground": false, - "showgrid": false, - "showline": false, - "showticklabels": false, - "title": { - "text": "" + { + "cell_type": "code", + "execution_count": 10, + "metadata": {}, + "outputs": [ + { + "data": { + "text/html": [ + "
Graph named 'long_test' with 20 nodes and 21 edges\n",
+                                   "
\n" + ], + "text/plain": [ + "Graph named \u001b[32m'long_test'\u001b[0m with \u001b[1;36m20\u001b[0m nodes and \u001b[1;36m21\u001b[0m edges\n" + ] + }, + "metadata": {}, + "output_type": "display_data" + }, + { + "data": { + "image/png": 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+ "gridcolor": "white", + "linecolor": "white", + "ticks": "", + "title": { + "standoff": 15 + }, + "zerolinecolor": "white", + "zerolinewidth": 2 + } + } + }, + "width": 620 + } + } + }, + "metadata": {}, + "output_type": "display_data" + } + ], + "source": [ + "gm.plotly_molecular_graph(graph)" + ] }, - "colorway": [ - "#636efa", - "#EF553B", - "#00cc96", - "#ab63fa", - "#FFA15A", - "#19d3f3", - "#FF6692", - "#B6E880", - "#FF97FF", - "#FECB52" - ], - "font": { - "color": "#2a3f5f" + { + "cell_type": "markdown", + "metadata": {}, + "source": [ + "## Adding Features\n", + "Graphein can add lots of features to graph nodes and edges from RDKit\n", + "\n", + "### Node Features\n", + "\n", + "\n" + ] }, - "geo": { - "bgcolor": "white", - "lakecolor": "white", - "landcolor": "#E5ECF6", - "showlakes": true, - "showland": true, - "subunitcolor": "white" + { + "cell_type": "code", + "execution_count": 14, + "metadata": {}, + "outputs": [ + { + "name": "stderr", + "output_type": "stream", + 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"hoverlabel": { - "align": "left" + { + "cell_type": "markdown", + "metadata": {}, + "source": [ + "### Edge Features" + ] }, - "hovermode": "closest", - "mapbox": { - "style": "light" + { + "cell_type": "code", + "execution_count": 15, + "metadata": {}, + "outputs": [ + { + "name": "stderr", + "output_type": "stream", + "text": [ + "INFO:graphein.molecule.edges.distance:Found: 3 KNN edges\n", + "INFO:graphein.molecule.edges.distance:Found: 9 distance edges for radius 5.0\n", + "DEBUG:graphein.molecule.features.edges.bonds:No RDKit bond found on edge C:0-C:0\n", + "DEBUG:graphein.molecule.features.edges.bonds:No RDKit bond found on edge C:0-N:2\n", + "DEBUG:graphein.molecule.features.edges.bonds:No RDKit bond found on edge C:1-C:1\n", + "DEBUG:graphein.molecule.features.edges.bonds:No RDKit bond found on edge N:2-N:2\n", + "DEBUG:graphein.molecule.features.edges.bonds:No RDKit bond found on edge C:0-C:0\n", + "DEBUG:graphein.molecule.features.edges.bonds:No RDKit bond found on edge C:0-N:2\n", + "DEBUG:graphein.molecule.features.edges.bonds:No RDKit bond found on edge C:1-C:1\n", + "DEBUG:graphein.molecule.features.edges.bonds:No RDKit bond found on edge N:2-N:2\n", + "DEBUG:graphein.molecule.features.edges.bonds:No RDKit bond found on edge C:0-C:0\n", + "DEBUG:graphein.molecule.features.edges.bonds:No RDKit bond found on edge C:0-N:2\n", + "DEBUG:graphein.molecule.features.edges.bonds:No RDKit bond found on edge C:1-C:1\n", + "DEBUG:graphein.molecule.features.edges.bonds:No RDKit bond found on edge N:2-N:2\n", + "DEBUG:graphein.molecule.features.edges.bonds:No RDKit bond found on edge C:0-C:0\n", + "DEBUG:graphein.molecule.features.edges.bonds:No RDKit bond found on edge C:0-N:2\n", + "DEBUG:graphein.molecule.features.edges.bonds:No RDKit bond found on edge C:1-C:1\n", + "DEBUG:graphein.molecule.features.edges.bonds:No RDKit bond found on edge N:2-N:2\n", + "DEBUG:graphein.molecule.features.edges.bonds:No RDKit bond found on edge C:0-C:0\n", + "DEBUG:graphein.molecule.features.edges.bonds:No RDKit bond found on edge C:0-N:2\n", + "DEBUG:graphein.molecule.features.edges.bonds:No RDKit bond found on edge C:1-C:1\n", + "DEBUG:graphein.molecule.features.edges.bonds:No RDKit bond found on edge N:2-N:2\n", + "DEBUG:graphein.molecule.features.edges.bonds:No RDKit bond found on edge C:0-C:0\n", + "DEBUG:graphein.molecule.features.edges.bonds:No RDKit bond found on edge C:0-N:2\n", + "DEBUG:graphein.molecule.features.edges.bonds:No RDKit bond found on edge C:1-C:1\n", + "DEBUG:graphein.molecule.features.edges.bonds:No RDKit bond found on edge N:2-N:2\n", + "DEBUG:graphein.molecule.features.edges.bonds:No RDKit bond found on edge C:0-C:0\n", + "DEBUG:graphein.molecule.features.edges.bonds:No RDKit bond found on edge C:0-N:2\n", + "DEBUG:graphein.molecule.features.edges.bonds:No RDKit bond found on edge C:1-C:1\n", + "DEBUG:graphein.molecule.features.edges.bonds:No RDKit bond found on edge N:2-N:2\n" + ] + }, + { + "data": { + "text/html": [ + "
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+                                   "    'name': 'short_test',\n",
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+                                   "    'config': MoleculeGraphConfig(verbose=False, add_hs=False, generate_conformer=False, \n",
+                                   "edge_construction_functions=[<function add_fully_connected_edges at 0x7f10c593f9d0>, \n",
+                                   "<function add_k_nn_edges at 0x7f10c593fa60>, <function add_distance_threshold at \n",
+                                   "0x7f10c593f940>, <function add_atom_bonds at 0x7f10c593f550>], \n",
+                                   "node_metadata_functions=[<function atom_type_one_hot at 0x7f10c56e1f70>], \n",
+                                   "edge_metadata_functions=None, graph_metadata_functions=[<function mol_descriptors at \n",
+                                   "0x7f10c5945280>]),\n",
+                                   "    'MaxEStateIndex': 4.847222222222222,\n",
+                                   "    'MinEStateIndex': 0.75,\n",
+                                   "    'MaxAbsEStateIndex': 4.847222222222222,\n",
+                                   "    'MinAbsEStateIndex': 0.75,\n",
+                                   "    'qed': 0.40623709538988323,\n",
+                                   "    'MolWt': 45.084999999999994,\n",
+                                   "    'HeavyAtomMolWt': 38.028999999999996,\n",
+                                   "    'ExactMolWt': 45.057849223999995,\n",
+                                   "    'NumValenceElectrons': 20,\n",
+                                   "    'NumRadicalElectrons': 0,\n",
+                                   "    'MaxPartialCharge': -0.010576265829206462,\n",
+                                   "    'MinPartialCharge': -0.3307484184390755,\n",
+                                   "    'MaxAbsPartialCharge': 0.3307484184390755,\n",
+                                   "    'MinAbsPartialCharge': 0.010576265829206462,\n",
+                                   "    'FpDensityMorgan1': 2.0,\n",
+                                   "    'FpDensityMorgan2': 2.0,\n",
+                                   "    'FpDensityMorgan3': 2.0,\n",
+                                   "    'BalabanJ': 1.6329931618554523,\n",
+                                   "    'BertzCT': 2.7548875021634682,\n",
+                                   "    'Chi0': 2.7071067811865475,\n",
+                                   "    'Chi0n': 2.284457050376173,\n",
+                                   "    'Chi0v': 2.284457050376173,\n",
+                                   "    'Chi1': 1.4142135623730951,\n",
+                                   "    'Chi1n': 1.1153550716504106,\n",
+                                   "    'Chi1v': 1.1153550716504106,\n",
+                                   "    'Chi2n': 0.408248290463863,\n",
+                                   "    'Chi2v': 0.408248290463863,\n",
+                                   "    'Chi3n': 0.0,\n",
+                                   "    'Chi3v': 0.0,\n",
+                                   "    'Chi4n': 0.0,\n",
+                                   "    'Chi4v': 0.0,\n",
+                                   "    'HallKierAlpha': -0.04,\n",
+                                   "    'Ipc': 2.7548875021634682,\n",
+                                   "    'Kappa1': 2.9600000000000004,\n",
+                                   "    'Kappa2': 1.96,\n",
+                                   "    'Kappa3': 1.9600000000000033,\n",
+                                   "    'LabuteASA': 20.444083839238875,\n",
+                                   "    'PEOE_VSA1': 5.733667477162185,\n",
+                                   "    'PEOE_VSA10': 0.0,\n",
+                                   "    'PEOE_VSA11': 0.0,\n",
+                                   "    'PEOE_VSA12': 0.0,\n",
+                                   "    'PEOE_VSA13': 0.0,\n",
+                                   "    'PEOE_VSA14': 0.0,\n",
+                                   "    'PEOE_VSA2': 0.0,\n",
+                                   "    'PEOE_VSA3': 0.0,\n",
+                                   "    'PEOE_VSA4': 0.0,\n",
+                                   "    'PEOE_VSA5': 0.0,\n",
+                                   "    'PEOE_VSA6': 6.923737199690624,\n",
+                                   "    'PEOE_VSA7': 6.544756405912575,\n",
+                                   "    'PEOE_VSA8': 0.0,\n",
+                                   "    'PEOE_VSA9': 0.0,\n",
+                                   "    'SMR_VSA1': 0.0,\n",
+                                   "    'SMR_VSA10': 0.0,\n",
+                                   "    'SMR_VSA2': 0.0,\n",
+                                   "    'SMR_VSA3': 0.0,\n",
+                                   "    'SMR_VSA4': 5.733667477162185,\n",
+                                   "    'SMR_VSA5': 6.923737199690624,\n",
+                                   "    'SMR_VSA6': 6.544756405912575,\n",
+                                   "    'SMR_VSA7': 0.0,\n",
+                                   "    'SMR_VSA8': 0.0,\n",
+                                   "    'SMR_VSA9': 0.0,\n",
+                                   "    'SlogP_VSA1': 5.733667477162185,\n",
+                                   "    'SlogP_VSA10': 0.0,\n",
+                                   "    'SlogP_VSA11': 0.0,\n",
+                                   "    'SlogP_VSA12': 0.0,\n",
+                                   "    'SlogP_VSA2': 6.544756405912575,\n",
+                                   "    'SlogP_VSA3': 0.0,\n",
+                                   "    'SlogP_VSA4': 0.0,\n",
+                                   "    'SlogP_VSA5': 6.923737199690624,\n",
+                                   "    'SlogP_VSA6': 0.0,\n",
+                                   "    'SlogP_VSA7': 0.0,\n",
+                                   "    'SlogP_VSA8': 0.0,\n",
+                                   "    'SlogP_VSA9': 0.0,\n",
+                                   "    'TPSA': 26.02,\n",
+                                   "    'EState_VSA1': 0.0,\n",
+                                   "    'EState_VSA10': 0.0,\n",
+                                   "    'EState_VSA11': 0.0,\n",
+                                   "    'EState_VSA2': 0.0,\n",
+                                   "    'EState_VSA3': 0.0,\n",
+                                   "    'EState_VSA4': 6.544756405912575,\n",
+                                   "    'EState_VSA5': 0.0,\n",
+                                   "    'EState_VSA6': 0.0,\n",
+                                   "    'EState_VSA7': 6.923737199690624,\n",
+                                   "    'EState_VSA8': 0.0,\n",
+                                   "    'EState_VSA9': 5.733667477162185,\n",
+                                   "    'VSA_EState1': 0.0,\n",
+                                   "    'VSA_EState10': 0.0,\n",
+                                   "    'VSA_EState2': 0.0,\n",
+                                   "    'VSA_EState3': 0.0,\n",
+                                   "    'VSA_EState4': 4.847222222222222,\n",
+                                   "    'VSA_EState5': 0.0,\n",
+                                   "    'VSA_EState6': 0.0,\n",
+                                   "    'VSA_EState7': 0.0,\n",
+                                   "    'VSA_EState8': 2.6527777777777777,\n",
+                                   "    'VSA_EState9': 0.0,\n",
+                                   "    'FractionCSP3': 1.0,\n",
+                                   "    'HeavyAtomCount': 3,\n",
+                                   "    'NHOHCount': 2,\n",
+                                   "    'NOCount': 1,\n",
+                                   "    'NumAliphaticCarbocycles': 0,\n",
+                                   "    'NumAliphaticHeterocycles': 0,\n",
+                                   "    'NumAliphaticRings': 0,\n",
+                                   "    'NumAromaticCarbocycles': 0,\n",
+                                   "    'NumAromaticHeterocycles': 0,\n",
+                                   "    'NumAromaticRings': 0,\n",
+                                   "    'NumHAcceptors': 1,\n",
+                                   "    'NumHDonors': 1,\n",
+                                   "    'NumHeteroatoms': 1,\n",
+                                   "    'NumRotatableBonds': 0,\n",
+                                   "    'NumSaturatedCarbocycles': 0,\n",
+                                   "    'NumSaturatedHeterocycles': 0,\n",
+                                   "    'NumSaturatedRings': 0,\n",
+                                   "    'RingCount': 0,\n",
+                                   "    'MolLogP': -0.03499999999999981,\n",
+                                   "    'MolMR': 14.728400000000002,\n",
+                                   "    'fr_Al_COO': 0,\n",
+                                   "    'fr_Al_OH': 0,\n",
+                                   "    'fr_Al_OH_noTert': 0,\n",
+                                   "    'fr_ArN': 0,\n",
+                                   "    'fr_Ar_COO': 0,\n",
+                                   "    'fr_Ar_N': 0,\n",
+                                   "    'fr_Ar_NH': 0,\n",
+                                   "    'fr_Ar_OH': 0,\n",
+                                   "    'fr_COO': 0,\n",
+                                   "    'fr_COO2': 0,\n",
+                                   "    'fr_C_O': 0,\n",
+                                   "    'fr_C_O_noCOO': 0,\n",
+                                   "    'fr_C_S': 0,\n",
+                                   "    'fr_HOCCN': 0,\n",
+                                   "    'fr_Imine': 0,\n",
+                                   "    'fr_NH0': 0,\n",
+                                   "    'fr_NH1': 0,\n",
+                                   "    'fr_NH2': 1,\n",
+                                   "    'fr_N_O': 0,\n",
+                                   "    'fr_Ndealkylation1': 0,\n",
+                                   "    'fr_Ndealkylation2': 0,\n",
+                                   "    'fr_Nhpyrrole': 0,\n",
+                                   "    'fr_SH': 0,\n",
+                                   "    'fr_aldehyde': 0,\n",
+                                   "    'fr_alkyl_carbamate': 0,\n",
+                                   "    'fr_alkyl_halide': 0,\n",
+                                   "    'fr_allylic_oxid': 0,\n",
+                                   "    'fr_amide': 0,\n",
+                                   "    'fr_amidine': 0,\n",
+                                   "    'fr_aniline': 0,\n",
+                                   "    'fr_aryl_methyl': 0,\n",
+                                   "    'fr_azide': 0,\n",
+                                   "    'fr_azo': 0,\n",
+                                   "    'fr_barbitur': 0,\n",
+                                   "    'fr_benzene': 0,\n",
+                                   "    'fr_benzodiazepine': 0,\n",
+                                   "    'fr_bicyclic': 0,\n",
+                                   "    'fr_diazo': 0,\n",
+                                   "    'fr_dihydropyridine': 0,\n",
+                                   "    'fr_epoxide': 0,\n",
+                                   "    'fr_ester': 0,\n",
+                                   "    'fr_ether': 0,\n",
+                                   "    'fr_furan': 0,\n",
+                                   "    'fr_guanido': 0,\n",
+                                   "    'fr_halogen': 0,\n",
+                                   "    'fr_hdrzine': 0,\n",
+                                   "    'fr_hdrzone': 0,\n",
+                                   "    'fr_imidazole': 0,\n",
+                                   "    'fr_imide': 0,\n",
+                                   "    'fr_isocyan': 0,\n",
+                                   "    'fr_isothiocyan': 0,\n",
+                                   "    'fr_ketone': 0,\n",
+                                   "    'fr_ketone_Topliss': 0,\n",
+                                   "    'fr_lactam': 0,\n",
+                                   "    'fr_lactone': 0,\n",
+                                   "    'fr_methoxy': 0,\n",
+                                   "    'fr_morpholine': 0,\n",
+                                   "    'fr_nitrile': 0,\n",
+                                   "    'fr_nitro': 0,\n",
+                                   "    'fr_nitro_arom': 0,\n",
+                                   "    'fr_nitro_arom_nonortho': 0,\n",
+                                   "    'fr_nitroso': 0,\n",
+                                   "    'fr_oxazole': 0,\n",
+                                   "    'fr_oxime': 0,\n",
+                                   "    'fr_para_hydroxylation': 0,\n",
+                                   "    'fr_phenol': 0,\n",
+                                   "    'fr_phenol_noOrthoHbond': 0,\n",
+                                   "    'fr_phos_acid': 0,\n",
+                                   "    'fr_phos_ester': 0,\n",
+                                   "    'fr_piperdine': 0,\n",
+                                   "    'fr_piperzine': 0,\n",
+                                   "    'fr_priamide': 0,\n",
+                                   "    'fr_prisulfonamd': 0,\n",
+                                   "    'fr_pyridine': 0,\n",
+                                   "    'fr_quatN': 0,\n",
+                                   "    'fr_sulfide': 0,\n",
+                                   "    'fr_sulfonamd': 0,\n",
+                                   "    'fr_sulfone': 0,\n",
+                                   "    'fr_term_acetylene': 0,\n",
+                                   "    'fr_tetrazole': 0,\n",
+                                   "    'fr_thiazole': 0,\n",
+                                   "    'fr_thiocyan': 0,\n",
+                                   "    'fr_thiophene': 0,\n",
+                                   "    'fr_unbrch_alkane': 0,\n",
+                                   "    'fr_urea': 0\n",
+                                   "}\n",
+                                   "
\n" + ], + "text/plain": [ + "\u001b[1m{\u001b[0m\n", + " \u001b[32m'name'\u001b[0m: \u001b[32m'short_test'\u001b[0m,\n", + " \u001b[32m'rdmol'\u001b[0m: \u001b[1m<\u001b[0m\u001b[1;95mrdkit.Chem.rdchem.Mol\u001b[0m\u001b[39m object at \u001b[0m\u001b[1;36m0x7f10c5030820\u001b[0m\u001b[1m>\u001b[0m,\n", + " \u001b[32m'coords'\u001b[0m: \u001b[1;35marray\u001b[0m\u001b[1m(\u001b[0m\u001b[1m[\u001b[0m\u001b[1m[\u001b[0m \u001b[1;36m0.9862\u001b[0m, \u001b[1;36m-0.257\u001b[0m , \u001b[1;36m-0.1905\u001b[0m\u001b[1m]\u001b[0m,\n", + " \u001b[1m[\u001b[0m\u001b[1;36m-0.2052\u001b[0m, \u001b[1;36m0.2236\u001b[0m, \u001b[1;36m0.6206\u001b[0m\u001b[1m]\u001b[0m,\n", + " \u001b[1m[\u001b[0m\u001b[1;36m-1.4201\u001b[0m, \u001b[1;36m0.2357\u001b[0m, \u001b[1;36m-0.1847\u001b[0m\u001b[1m]\u001b[0m\u001b[1m]\u001b[0m\u001b[1m)\u001b[0m,\n", + " \u001b[32m'smiles'\u001b[0m: \u001b[32m'CCN'\u001b[0m,\n", + " \u001b[32m'config'\u001b[0m: \u001b[1;35mMoleculeGraphConfig\u001b[0m\u001b[1m(\u001b[0m\u001b[33mverbose\u001b[0m=\u001b[3;91mFalse\u001b[0m, \u001b[33madd_hs\u001b[0m=\u001b[3;91mFalse\u001b[0m, \u001b[33mgenerate_conformer\u001b[0m=\u001b[3;91mFalse\u001b[0m, \n", + "\u001b[33medge_construction_functions\u001b[0m=\u001b[1m[\u001b[0m\u001b[1m<\u001b[0m\u001b[1;95mfunction\u001b[0m\u001b[39m add_fully_connected_edges at \u001b[0m\u001b[1;36m0x7f10c593f9d0\u001b[0m\u001b[1m>\u001b[0m, \n", + "\u001b[1m<\u001b[0m\u001b[1;95mfunction\u001b[0m\u001b[39m add_k_nn_edges at \u001b[0m\u001b[1;36m0x7f10c593fa60\u001b[0m\u001b[1m>\u001b[0m, \u001b[1m<\u001b[0m\u001b[1;95mfunction\u001b[0m\u001b[39m add_distance_threshold at \u001b[0m\n", + "\u001b[1;36m0x7f10c593f940\u001b[0m\u001b[1m>\u001b[0m, \u001b[1m<\u001b[0m\u001b[1;95mfunction\u001b[0m\u001b[39m add_atom_bonds at \u001b[0m\u001b[1;36m0x7f10c593f550\u001b[0m\u001b[1m>\u001b[0m\u001b[1m]\u001b[0m, \n", + "\u001b[33mnode_metadata_functions\u001b[0m=\u001b[1m[\u001b[0m\u001b[1m<\u001b[0m\u001b[1;95mfunction\u001b[0m\u001b[39m atom_type_one_hot at \u001b[0m\u001b[1;36m0x7f10c56e1f70\u001b[0m\u001b[1m>\u001b[0m\u001b[1m]\u001b[0m, \n", + "\u001b[33medge_metadata_functions\u001b[0m=\u001b[3;35mNone\u001b[0m, \u001b[33mgraph_metadata_functions\u001b[0m=\u001b[1m[\u001b[0m\u001b[1m<\u001b[0m\u001b[1;95mfunction\u001b[0m\u001b[39m mol_descriptors at \u001b[0m\n", + "\u001b[1;36m0x7f10c5945280\u001b[0m\u001b[1m>\u001b[0m\u001b[1m]\u001b[0m\u001b[1m)\u001b[0m,\n", + " \u001b[32m'MaxEStateIndex'\u001b[0m: \u001b[1;36m4.847222222222222\u001b[0m,\n", + " \u001b[32m'MinEStateIndex'\u001b[0m: \u001b[1;36m0.75\u001b[0m,\n", + " \u001b[32m'MaxAbsEStateIndex'\u001b[0m: \u001b[1;36m4.847222222222222\u001b[0m,\n", + " \u001b[32m'MinAbsEStateIndex'\u001b[0m: \u001b[1;36m0.75\u001b[0m,\n", + " \u001b[32m'qed'\u001b[0m: \u001b[1;36m0.40623709538988323\u001b[0m,\n", + " \u001b[32m'MolWt'\u001b[0m: \u001b[1;36m45.084999999999994\u001b[0m,\n", + " \u001b[32m'HeavyAtomMolWt'\u001b[0m: \u001b[1;36m38.028999999999996\u001b[0m,\n", + " \u001b[32m'ExactMolWt'\u001b[0m: \u001b[1;36m45.057849223999995\u001b[0m,\n", + " \u001b[32m'NumValenceElectrons'\u001b[0m: \u001b[1;36m20\u001b[0m,\n", + " \u001b[32m'NumRadicalElectrons'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", + " \u001b[32m'MaxPartialCharge'\u001b[0m: \u001b[1;36m-0.010576265829206462\u001b[0m,\n", + " \u001b[32m'MinPartialCharge'\u001b[0m: \u001b[1;36m-0.3307484184390755\u001b[0m,\n", + " \u001b[32m'MaxAbsPartialCharge'\u001b[0m: \u001b[1;36m0.3307484184390755\u001b[0m,\n", + " \u001b[32m'MinAbsPartialCharge'\u001b[0m: \u001b[1;36m0.010576265829206462\u001b[0m,\n", + " \u001b[32m'FpDensityMorgan1'\u001b[0m: \u001b[1;36m2.0\u001b[0m,\n", + " \u001b[32m'FpDensityMorgan2'\u001b[0m: \u001b[1;36m2.0\u001b[0m,\n", + " \u001b[32m'FpDensityMorgan3'\u001b[0m: \u001b[1;36m2.0\u001b[0m,\n", + " \u001b[32m'BalabanJ'\u001b[0m: \u001b[1;36m1.6329931618554523\u001b[0m,\n", + " \u001b[32m'BertzCT'\u001b[0m: \u001b[1;36m2.7548875021634682\u001b[0m,\n", + " \u001b[32m'Chi0'\u001b[0m: \u001b[1;36m2.7071067811865475\u001b[0m,\n", + " \u001b[32m'Chi0n'\u001b[0m: \u001b[1;36m2.284457050376173\u001b[0m,\n", + " \u001b[32m'Chi0v'\u001b[0m: \u001b[1;36m2.284457050376173\u001b[0m,\n", + " \u001b[32m'Chi1'\u001b[0m: \u001b[1;36m1.4142135623730951\u001b[0m,\n", + " \u001b[32m'Chi1n'\u001b[0m: \u001b[1;36m1.1153550716504106\u001b[0m,\n", + " \u001b[32m'Chi1v'\u001b[0m: \u001b[1;36m1.1153550716504106\u001b[0m,\n", + " \u001b[32m'Chi2n'\u001b[0m: \u001b[1;36m0.408248290463863\u001b[0m,\n", + " \u001b[32m'Chi2v'\u001b[0m: \u001b[1;36m0.408248290463863\u001b[0m,\n", + " \u001b[32m'Chi3n'\u001b[0m: \u001b[1;36m0.0\u001b[0m,\n", + " \u001b[32m'Chi3v'\u001b[0m: \u001b[1;36m0.0\u001b[0m,\n", + " \u001b[32m'Chi4n'\u001b[0m: \u001b[1;36m0.0\u001b[0m,\n", + " \u001b[32m'Chi4v'\u001b[0m: \u001b[1;36m0.0\u001b[0m,\n", + " \u001b[32m'HallKierAlpha'\u001b[0m: \u001b[1;36m-0.04\u001b[0m,\n", + " \u001b[32m'Ipc'\u001b[0m: \u001b[1;36m2.7548875021634682\u001b[0m,\n", + " \u001b[32m'Kappa1'\u001b[0m: \u001b[1;36m2.9600000000000004\u001b[0m,\n", + " \u001b[32m'Kappa2'\u001b[0m: \u001b[1;36m1.96\u001b[0m,\n", + " \u001b[32m'Kappa3'\u001b[0m: \u001b[1;36m1.9600000000000033\u001b[0m,\n", + " \u001b[32m'LabuteASA'\u001b[0m: \u001b[1;36m20.444083839238875\u001b[0m,\n", + " \u001b[32m'PEOE_VSA1'\u001b[0m: \u001b[1;36m5.733667477162185\u001b[0m,\n", + " \u001b[32m'PEOE_VSA10'\u001b[0m: \u001b[1;36m0.0\u001b[0m,\n", + " \u001b[32m'PEOE_VSA11'\u001b[0m: \u001b[1;36m0.0\u001b[0m,\n", + " \u001b[32m'PEOE_VSA12'\u001b[0m: \u001b[1;36m0.0\u001b[0m,\n", + " \u001b[32m'PEOE_VSA13'\u001b[0m: \u001b[1;36m0.0\u001b[0m,\n", + " \u001b[32m'PEOE_VSA14'\u001b[0m: \u001b[1;36m0.0\u001b[0m,\n", + " \u001b[32m'PEOE_VSA2'\u001b[0m: \u001b[1;36m0.0\u001b[0m,\n", + " \u001b[32m'PEOE_VSA3'\u001b[0m: \u001b[1;36m0.0\u001b[0m,\n", + " \u001b[32m'PEOE_VSA4'\u001b[0m: \u001b[1;36m0.0\u001b[0m,\n", + " \u001b[32m'PEOE_VSA5'\u001b[0m: \u001b[1;36m0.0\u001b[0m,\n", + " \u001b[32m'PEOE_VSA6'\u001b[0m: \u001b[1;36m6.923737199690624\u001b[0m,\n", + " \u001b[32m'PEOE_VSA7'\u001b[0m: \u001b[1;36m6.544756405912575\u001b[0m,\n", + " \u001b[32m'PEOE_VSA8'\u001b[0m: \u001b[1;36m0.0\u001b[0m,\n", + " \u001b[32m'PEOE_VSA9'\u001b[0m: \u001b[1;36m0.0\u001b[0m,\n", + " \u001b[32m'SMR_VSA1'\u001b[0m: \u001b[1;36m0.0\u001b[0m,\n", + " \u001b[32m'SMR_VSA10'\u001b[0m: \u001b[1;36m0.0\u001b[0m,\n", + " \u001b[32m'SMR_VSA2'\u001b[0m: \u001b[1;36m0.0\u001b[0m,\n", + " \u001b[32m'SMR_VSA3'\u001b[0m: \u001b[1;36m0.0\u001b[0m,\n", + " \u001b[32m'SMR_VSA4'\u001b[0m: \u001b[1;36m5.733667477162185\u001b[0m,\n", + " \u001b[32m'SMR_VSA5'\u001b[0m: \u001b[1;36m6.923737199690624\u001b[0m,\n", + " \u001b[32m'SMR_VSA6'\u001b[0m: \u001b[1;36m6.544756405912575\u001b[0m,\n", + " \u001b[32m'SMR_VSA7'\u001b[0m: \u001b[1;36m0.0\u001b[0m,\n", + " \u001b[32m'SMR_VSA8'\u001b[0m: \u001b[1;36m0.0\u001b[0m,\n", + " \u001b[32m'SMR_VSA9'\u001b[0m: \u001b[1;36m0.0\u001b[0m,\n", + " \u001b[32m'SlogP_VSA1'\u001b[0m: \u001b[1;36m5.733667477162185\u001b[0m,\n", + " \u001b[32m'SlogP_VSA10'\u001b[0m: \u001b[1;36m0.0\u001b[0m,\n", + " \u001b[32m'SlogP_VSA11'\u001b[0m: \u001b[1;36m0.0\u001b[0m,\n", + " \u001b[32m'SlogP_VSA12'\u001b[0m: \u001b[1;36m0.0\u001b[0m,\n", + " \u001b[32m'SlogP_VSA2'\u001b[0m: \u001b[1;36m6.544756405912575\u001b[0m,\n", + " \u001b[32m'SlogP_VSA3'\u001b[0m: \u001b[1;36m0.0\u001b[0m,\n", + " \u001b[32m'SlogP_VSA4'\u001b[0m: \u001b[1;36m0.0\u001b[0m,\n", + " \u001b[32m'SlogP_VSA5'\u001b[0m: \u001b[1;36m6.923737199690624\u001b[0m,\n", + " \u001b[32m'SlogP_VSA6'\u001b[0m: \u001b[1;36m0.0\u001b[0m,\n", + " \u001b[32m'SlogP_VSA7'\u001b[0m: \u001b[1;36m0.0\u001b[0m,\n", + " \u001b[32m'SlogP_VSA8'\u001b[0m: \u001b[1;36m0.0\u001b[0m,\n", + " \u001b[32m'SlogP_VSA9'\u001b[0m: \u001b[1;36m0.0\u001b[0m,\n", + " \u001b[32m'TPSA'\u001b[0m: \u001b[1;36m26.02\u001b[0m,\n", + " \u001b[32m'EState_VSA1'\u001b[0m: \u001b[1;36m0.0\u001b[0m,\n", + " \u001b[32m'EState_VSA10'\u001b[0m: \u001b[1;36m0.0\u001b[0m,\n", + " \u001b[32m'EState_VSA11'\u001b[0m: \u001b[1;36m0.0\u001b[0m,\n", + " \u001b[32m'EState_VSA2'\u001b[0m: \u001b[1;36m0.0\u001b[0m,\n", + " \u001b[32m'EState_VSA3'\u001b[0m: \u001b[1;36m0.0\u001b[0m,\n", + " \u001b[32m'EState_VSA4'\u001b[0m: \u001b[1;36m6.544756405912575\u001b[0m,\n", + " \u001b[32m'EState_VSA5'\u001b[0m: \u001b[1;36m0.0\u001b[0m,\n", + " \u001b[32m'EState_VSA6'\u001b[0m: \u001b[1;36m0.0\u001b[0m,\n", + " \u001b[32m'EState_VSA7'\u001b[0m: \u001b[1;36m6.923737199690624\u001b[0m,\n", + " \u001b[32m'EState_VSA8'\u001b[0m: \u001b[1;36m0.0\u001b[0m,\n", + " \u001b[32m'EState_VSA9'\u001b[0m: \u001b[1;36m5.733667477162185\u001b[0m,\n", + " \u001b[32m'VSA_EState1'\u001b[0m: \u001b[1;36m0.0\u001b[0m,\n", + " \u001b[32m'VSA_EState10'\u001b[0m: \u001b[1;36m0.0\u001b[0m,\n", + " \u001b[32m'VSA_EState2'\u001b[0m: \u001b[1;36m0.0\u001b[0m,\n", + " \u001b[32m'VSA_EState3'\u001b[0m: \u001b[1;36m0.0\u001b[0m,\n", + " \u001b[32m'VSA_EState4'\u001b[0m: \u001b[1;36m4.847222222222222\u001b[0m,\n", + " \u001b[32m'VSA_EState5'\u001b[0m: \u001b[1;36m0.0\u001b[0m,\n", + " \u001b[32m'VSA_EState6'\u001b[0m: \u001b[1;36m0.0\u001b[0m,\n", + " \u001b[32m'VSA_EState7'\u001b[0m: \u001b[1;36m0.0\u001b[0m,\n", + " \u001b[32m'VSA_EState8'\u001b[0m: \u001b[1;36m2.6527777777777777\u001b[0m,\n", + " \u001b[32m'VSA_EState9'\u001b[0m: \u001b[1;36m0.0\u001b[0m,\n", + " \u001b[32m'FractionCSP3'\u001b[0m: \u001b[1;36m1.0\u001b[0m,\n", + " \u001b[32m'HeavyAtomCount'\u001b[0m: \u001b[1;36m3\u001b[0m,\n", + " \u001b[32m'NHOHCount'\u001b[0m: \u001b[1;36m2\u001b[0m,\n", + " \u001b[32m'NOCount'\u001b[0m: \u001b[1;36m1\u001b[0m,\n", + " \u001b[32m'NumAliphaticCarbocycles'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", + " \u001b[32m'NumAliphaticHeterocycles'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", + " \u001b[32m'NumAliphaticRings'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", + " \u001b[32m'NumAromaticCarbocycles'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", + " \u001b[32m'NumAromaticHeterocycles'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", + " \u001b[32m'NumAromaticRings'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", + " \u001b[32m'NumHAcceptors'\u001b[0m: \u001b[1;36m1\u001b[0m,\n", + " \u001b[32m'NumHDonors'\u001b[0m: \u001b[1;36m1\u001b[0m,\n", + " \u001b[32m'NumHeteroatoms'\u001b[0m: \u001b[1;36m1\u001b[0m,\n", + " \u001b[32m'NumRotatableBonds'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", + " \u001b[32m'NumSaturatedCarbocycles'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", + " \u001b[32m'NumSaturatedHeterocycles'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", + " \u001b[32m'NumSaturatedRings'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", + " \u001b[32m'RingCount'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", + " \u001b[32m'MolLogP'\u001b[0m: \u001b[1;36m-0.03499999999999981\u001b[0m,\n", + " \u001b[32m'MolMR'\u001b[0m: \u001b[1;36m14.728400000000002\u001b[0m,\n", + " \u001b[32m'fr_Al_COO'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", + " \u001b[32m'fr_Al_OH'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", + " \u001b[32m'fr_Al_OH_noTert'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", + " \u001b[32m'fr_ArN'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", + " \u001b[32m'fr_Ar_COO'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", + " \u001b[32m'fr_Ar_N'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", + " \u001b[32m'fr_Ar_NH'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", + " \u001b[32m'fr_Ar_OH'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", + " \u001b[32m'fr_COO'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", + " \u001b[32m'fr_COO2'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", + " \u001b[32m'fr_C_O'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", + " \u001b[32m'fr_C_O_noCOO'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", + " \u001b[32m'fr_C_S'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", + " \u001b[32m'fr_HOCCN'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", + " \u001b[32m'fr_Imine'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", + " \u001b[32m'fr_NH0'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", + " \u001b[32m'fr_NH1'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", + " \u001b[32m'fr_NH2'\u001b[0m: \u001b[1;36m1\u001b[0m,\n", + " \u001b[32m'fr_N_O'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", + " \u001b[32m'fr_Ndealkylation1'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", + " \u001b[32m'fr_Ndealkylation2'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", + " \u001b[32m'fr_Nhpyrrole'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", + " \u001b[32m'fr_SH'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", + " \u001b[32m'fr_aldehyde'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", + " \u001b[32m'fr_alkyl_carbamate'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", + " \u001b[32m'fr_alkyl_halide'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", + " \u001b[32m'fr_allylic_oxid'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", + " \u001b[32m'fr_amide'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", + " \u001b[32m'fr_amidine'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", + " \u001b[32m'fr_aniline'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", + " \u001b[32m'fr_aryl_methyl'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", + " \u001b[32m'fr_azide'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", + " \u001b[32m'fr_azo'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", + " \u001b[32m'fr_barbitur'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", + " \u001b[32m'fr_benzene'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", + " \u001b[32m'fr_benzodiazepine'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", + " \u001b[32m'fr_bicyclic'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", + " \u001b[32m'fr_diazo'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", + " \u001b[32m'fr_dihydropyridine'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", + " \u001b[32m'fr_epoxide'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", + " \u001b[32m'fr_ester'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", + " \u001b[32m'fr_ether'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", + " \u001b[32m'fr_furan'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", + " \u001b[32m'fr_guanido'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", + " \u001b[32m'fr_halogen'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", + " \u001b[32m'fr_hdrzine'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", + " \u001b[32m'fr_hdrzone'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", + " \u001b[32m'fr_imidazole'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", + " \u001b[32m'fr_imide'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", + " \u001b[32m'fr_isocyan'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", + " \u001b[32m'fr_isothiocyan'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", + " \u001b[32m'fr_ketone'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", + " \u001b[32m'fr_ketone_Topliss'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", + " \u001b[32m'fr_lactam'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", + " \u001b[32m'fr_lactone'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", + " \u001b[32m'fr_methoxy'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", + " \u001b[32m'fr_morpholine'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", + " \u001b[32m'fr_nitrile'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", + " \u001b[32m'fr_nitro'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", + " \u001b[32m'fr_nitro_arom'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", + " \u001b[32m'fr_nitro_arom_nonortho'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", + " \u001b[32m'fr_nitroso'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", + " \u001b[32m'fr_oxazole'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", + " \u001b[32m'fr_oxime'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", + " \u001b[32m'fr_para_hydroxylation'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", + " \u001b[32m'fr_phenol'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", + " \u001b[32m'fr_phenol_noOrthoHbond'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", + " \u001b[32m'fr_phos_acid'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", + " \u001b[32m'fr_phos_ester'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", + " \u001b[32m'fr_piperdine'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", + " \u001b[32m'fr_piperzine'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", + " \u001b[32m'fr_priamide'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", + " \u001b[32m'fr_prisulfonamd'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", + " \u001b[32m'fr_pyridine'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", + " \u001b[32m'fr_quatN'\u001b[0m: 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gm.construct_graph(path=\"../tests/molecule/test_data/short_test.mol2\", config=config)\n", + "\n", + "print(graph.graph)" + ] }, - "shapedefaults": { - "line": { - "color": "#2a3f5f" - } - }, - "ternary": { - "aaxis": { - "gridcolor": "white", - "linecolor": "white", - "ticks": "" - }, - "baxis": { - "gridcolor": "white", - "linecolor": "white", - "ticks": "" - }, - "bgcolor": "#E5ECF6", - "caxis": { - "gridcolor": "white", - "linecolor": "white", - "ticks": "" - } + { + "cell_type": "code", + "execution_count": null, + "metadata": {}, + "outputs": [], + "source": [] + } + ], + "metadata": { + "interpreter": { + "hash": "18b92dcb3aeecaafcda3e696c227fe0e653d0ebba9b1df5f8e7485b6c09cf261" }, - "title": { - "x": 0.05 + "kernelspec": { + "display_name": "Python 3.8.10 ('graphein-dev-test')", + "language": "python", + "name": "python3" }, - "xaxis": { - "automargin": true, - "gridcolor": "white", - "linecolor": "white", - "ticks": "", - "title": { - "standoff": 15 - }, - "zerolinecolor": "white", - "zerolinewidth": 2 + "language_info": { + "codemirror_mode": { + "name": "ipython", + "version": 3 + }, + "file_extension": ".py", + "mimetype": "text/x-python", + "name": "python", + "nbconvert_exporter": "python", + "pygments_lexer": "ipython3", + "version": "3.8.10" }, - "yaxis": { - "automargin": true, - "gridcolor": "white", - "linecolor": "white", - "ticks": "", - "title": { - "standoff": 15 - }, - "zerolinecolor": "white", - "zerolinewidth": 2 - } - } - }, - "width": 620 - } - } - }, - "metadata": {}, - "output_type": "display_data" - } - ], - "source": [ - "gm.plotly_molecular_graph(graph)" - ] - }, - { - "cell_type": "markdown", - "metadata": {}, - "source": [ - "## Adding Features\n", - "Graphein can add lots of features to graph nodes and edges from RDKit\n", - "\n", - "### Node Features\n", - "\n", - "\n" - ] - }, - { - "cell_type": "code", - "execution_count": 14, - "metadata": {}, - "outputs": [ - { - "name": "stderr", - "output_type": "stream", - "text": [ - "INFO:graphein.molecule.edges.distance:Found: 3 KNN edges\n", - "INFO:graphein.molecule.edges.distance:Found: 9 distance edges for radius 5.0\n" - ] - }, - { - "data": { - "text/html": [ - "
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" \u001b[32m'chiral_tag'\u001b[0m: rdkit.Chem.rdchem.ChiralType.CHI_UNSPECIFIED,\n", - " \u001b[32m'is_ring_5'\u001b[0m: \u001b[3;91mFalse\u001b[0m,\n", - " \u001b[32m'is_ring_7'\u001b[0m: \u001b[3;91mFalse\u001b[0m\n", - "\u001b[1m}\u001b[0m\n" - ] - }, - "metadata": {}, - "output_type": "display_data" - } - ], - "source": [ - "from functools import partial\n", - "\n", - "config = gm.MoleculeGraphConfig(\n", - " node_metadata_functions=[\n", - " gm.atom_type_one_hot,\n", - " gm.atomic_mass,\n", - " gm.degree,\n", - " gm.total_degree,\n", - " gm.total_valence,\n", - " gm.explicit_valence,\n", - " gm.implicit_valence,\n", - " gm.num_explicit_h,\n", - " gm.num_implicit_h,\n", - " gm.total_num_h,\n", - " gm.num_radical_electrons,\n", - " gm.formal_charge,\n", - " gm.hybridization,\n", - " gm.is_aromatic,\n", - " gm.is_isotope,\n", - " gm.is_ring,\n", - " gm.chiral_tag,\n", - " partial(gm.is_ring_size, ring_size=5),\n", - " partial(gm.is_ring_size, ring_size=7)\n", - " ]\n", - ")\n", - "graph = gm.construct_graph(path=\"../tests/molecule/test_data/short_test.mol2\", config=config)\n", - "\n", - "for n, d in graph.nodes(data=True):\n", - " print(d)" - ] - }, - { - "cell_type": "markdown", - "metadata": {}, - "source": [ - "### Edge Features" - ] - }, - { - "cell_type": "code", - "execution_count": 15, - "metadata": {}, - "outputs": [ - { - "name": "stderr", - "output_type": "stream", - "text": [ - "INFO:graphein.molecule.edges.distance:Found: 3 KNN edges\n", - "INFO:graphein.molecule.edges.distance:Found: 9 distance edges for radius 5.0\n", - "DEBUG:graphein.molecule.features.edges.bonds:No RDKit bond found on edge C:0-C:0\n", - "DEBUG:graphein.molecule.features.edges.bonds:No RDKit bond found on edge C:0-N:2\n", - "DEBUG:graphein.molecule.features.edges.bonds:No RDKit bond found on edge C:1-C:1\n", - "DEBUG:graphein.molecule.features.edges.bonds:No RDKit bond found on edge N:2-N:2\n", - "DEBUG:graphein.molecule.features.edges.bonds:No RDKit bond found on edge C:0-C:0\n", - "DEBUG:graphein.molecule.features.edges.bonds:No RDKit bond found on edge C:0-N:2\n", - "DEBUG:graphein.molecule.features.edges.bonds:No RDKit bond found on edge C:1-C:1\n", - "DEBUG:graphein.molecule.features.edges.bonds:No RDKit bond found on edge N:2-N:2\n", - "DEBUG:graphein.molecule.features.edges.bonds:No RDKit bond found on edge C:0-C:0\n", - "DEBUG:graphein.molecule.features.edges.bonds:No RDKit bond found on edge C:0-N:2\n", - "DEBUG:graphein.molecule.features.edges.bonds:No RDKit bond found on edge C:1-C:1\n", - "DEBUG:graphein.molecule.features.edges.bonds:No RDKit bond found on edge N:2-N:2\n", - "DEBUG:graphein.molecule.features.edges.bonds:No RDKit bond found on edge C:0-C:0\n", - "DEBUG:graphein.molecule.features.edges.bonds:No RDKit bond found on edge C:0-N:2\n", - "DEBUG:graphein.molecule.features.edges.bonds:No RDKit bond found on edge C:1-C:1\n", - "DEBUG:graphein.molecule.features.edges.bonds:No RDKit bond found on edge N:2-N:2\n", - "DEBUG:graphein.molecule.features.edges.bonds:No RDKit bond found on edge C:0-C:0\n", - "DEBUG:graphein.molecule.features.edges.bonds:No RDKit bond found on edge C:0-N:2\n", - "DEBUG:graphein.molecule.features.edges.bonds:No RDKit bond found on edge C:1-C:1\n", - "DEBUG:graphein.molecule.features.edges.bonds:No RDKit bond found on edge N:2-N:2\n", - "DEBUG:graphein.molecule.features.edges.bonds:No RDKit bond found on edge C:0-C:0\n", - "DEBUG:graphein.molecule.features.edges.bonds:No RDKit bond found on edge C:0-N:2\n", - "DEBUG:graphein.molecule.features.edges.bonds:No RDKit bond found on edge C:1-C:1\n", - "DEBUG:graphein.molecule.features.edges.bonds:No RDKit bond found on edge N:2-N:2\n", - "DEBUG:graphein.molecule.features.edges.bonds:No RDKit bond found on edge C:0-C:0\n", - "DEBUG:graphein.molecule.features.edges.bonds:No RDKit bond found on edge C:0-N:2\n", - "DEBUG:graphein.molecule.features.edges.bonds:No RDKit bond found on edge C:1-C:1\n", - "DEBUG:graphein.molecule.features.edges.bonds:No RDKit bond found on edge N:2-N:2\n" - ] - }, - { - "data": { - "text/html": [ - "
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-       "    'MaxPartialCharge': -0.010576265829206462,\n",
-       "    'MinPartialCharge': -0.3307484184390755,\n",
-       "    'MaxAbsPartialCharge': 0.3307484184390755,\n",
-       "    'MinAbsPartialCharge': 0.010576265829206462,\n",
-       "    'FpDensityMorgan1': 2.0,\n",
-       "    'FpDensityMorgan2': 2.0,\n",
-       "    'FpDensityMorgan3': 2.0,\n",
-       "    'BalabanJ': 1.6329931618554523,\n",
-       "    'BertzCT': 2.7548875021634682,\n",
-       "    'Chi0': 2.7071067811865475,\n",
-       "    'Chi0n': 2.284457050376173,\n",
-       "    'Chi0v': 2.284457050376173,\n",
-       "    'Chi1': 1.4142135623730951,\n",
-       "    'Chi1n': 1.1153550716504106,\n",
-       "    'Chi1v': 1.1153550716504106,\n",
-       "    'Chi2n': 0.408248290463863,\n",
-       "    'Chi2v': 0.408248290463863,\n",
-       "    'Chi3n': 0.0,\n",
-       "    'Chi3v': 0.0,\n",
-       "    'Chi4n': 0.0,\n",
-       "    'Chi4v': 0.0,\n",
-       "    'HallKierAlpha': -0.04,\n",
-       "    'Ipc': 2.7548875021634682,\n",
-       "    'Kappa1': 2.9600000000000004,\n",
-       "    'Kappa2': 1.96,\n",
-       "    'Kappa3': 1.9600000000000033,\n",
-       "    'LabuteASA': 20.444083839238875,\n",
-       "    'PEOE_VSA1': 5.733667477162185,\n",
-       "    'PEOE_VSA10': 0.0,\n",
-       "    'PEOE_VSA11': 0.0,\n",
-       "    'PEOE_VSA12': 0.0,\n",
-       "    'PEOE_VSA13': 0.0,\n",
-       "    'PEOE_VSA14': 0.0,\n",
-       "    'PEOE_VSA2': 0.0,\n",
-       "    'PEOE_VSA3': 0.0,\n",
-       "    'PEOE_VSA4': 0.0,\n",
-       "    'PEOE_VSA5': 0.0,\n",
-       "    'PEOE_VSA6': 6.923737199690624,\n",
-       "    'PEOE_VSA7': 6.544756405912575,\n",
-       "    'PEOE_VSA8': 0.0,\n",
-       "    'PEOE_VSA9': 0.0,\n",
-       "    'SMR_VSA1': 0.0,\n",
-       "    'SMR_VSA10': 0.0,\n",
-       "    'SMR_VSA2': 0.0,\n",
-       "    'SMR_VSA3': 0.0,\n",
-       "    'SMR_VSA4': 5.733667477162185,\n",
-       "    'SMR_VSA5': 6.923737199690624,\n",
-       "    'SMR_VSA6': 6.544756405912575,\n",
-       "    'SMR_VSA7': 0.0,\n",
-       "    'SMR_VSA8': 0.0,\n",
-       "    'SMR_VSA9': 0.0,\n",
-       "    'SlogP_VSA1': 5.733667477162185,\n",
-       "    'SlogP_VSA10': 0.0,\n",
-       "    'SlogP_VSA11': 0.0,\n",
-       "    'SlogP_VSA12': 0.0,\n",
-       "    'SlogP_VSA2': 6.544756405912575,\n",
-       "    'SlogP_VSA3': 0.0,\n",
-       "    'SlogP_VSA4': 0.0,\n",
-       "    'SlogP_VSA5': 6.923737199690624,\n",
-       "    'SlogP_VSA6': 0.0,\n",
-       "    'SlogP_VSA7': 0.0,\n",
-       "    'SlogP_VSA8': 0.0,\n",
-       "    'SlogP_VSA9': 0.0,\n",
-       "    'TPSA': 26.02,\n",
-       "    'EState_VSA1': 0.0,\n",
-       "    'EState_VSA10': 0.0,\n",
-       "    'EState_VSA11': 0.0,\n",
-       "    'EState_VSA2': 0.0,\n",
-       "    'EState_VSA3': 0.0,\n",
-       "    'EState_VSA4': 6.544756405912575,\n",
-       "    'EState_VSA5': 0.0,\n",
-       "    'EState_VSA6': 0.0,\n",
-       "    'EState_VSA7': 6.923737199690624,\n",
-       "    'EState_VSA8': 0.0,\n",
-       "    'EState_VSA9': 5.733667477162185,\n",
-       "    'VSA_EState1': 0.0,\n",
-       "    'VSA_EState10': 0.0,\n",
-       "    'VSA_EState2': 0.0,\n",
-       "    'VSA_EState3': 0.0,\n",
-       "    'VSA_EState4': 4.847222222222222,\n",
-       "    'VSA_EState5': 0.0,\n",
-       "    'VSA_EState6': 0.0,\n",
-       "    'VSA_EState7': 0.0,\n",
-       "    'VSA_EState8': 2.6527777777777777,\n",
-       "    'VSA_EState9': 0.0,\n",
-       "    'FractionCSP3': 1.0,\n",
-       "    'HeavyAtomCount': 3,\n",
-       "    'NHOHCount': 2,\n",
-       "    'NOCount': 1,\n",
-       "    'NumAliphaticCarbocycles': 0,\n",
-       "    'NumAliphaticHeterocycles': 0,\n",
-       "    'NumAliphaticRings': 0,\n",
-       "    'NumAromaticCarbocycles': 0,\n",
-       "    'NumAromaticHeterocycles': 0,\n",
-       "    'NumAromaticRings': 0,\n",
-       "    'NumHAcceptors': 1,\n",
-       "    'NumHDonors': 1,\n",
-       "    'NumHeteroatoms': 1,\n",
-       "    'NumRotatableBonds': 0,\n",
-       "    'NumSaturatedCarbocycles': 0,\n",
-       "    'NumSaturatedHeterocycles': 0,\n",
-       "    'NumSaturatedRings': 0,\n",
-       "    'RingCount': 0,\n",
-       "    'MolLogP': -0.03499999999999981,\n",
-       "    'MolMR': 14.728400000000002,\n",
-       "    'fr_Al_COO': 0,\n",
-       "    'fr_Al_OH': 0,\n",
-       "    'fr_Al_OH_noTert': 0,\n",
-       "    'fr_ArN': 0,\n",
-       "    'fr_Ar_COO': 0,\n",
-       "    'fr_Ar_N': 0,\n",
-       "    'fr_Ar_NH': 0,\n",
-       "    'fr_Ar_OH': 0,\n",
-       "    'fr_COO': 0,\n",
-       "    'fr_COO2': 0,\n",
-       "    'fr_C_O': 0,\n",
-       "    'fr_C_O_noCOO': 0,\n",
-       "    'fr_C_S': 0,\n",
-       "    'fr_HOCCN': 0,\n",
-       "    'fr_Imine': 0,\n",
-       "    'fr_NH0': 0,\n",
-       "    'fr_NH1': 0,\n",
-       "    'fr_NH2': 1,\n",
-       "    'fr_N_O': 0,\n",
-       "    'fr_Ndealkylation1': 0,\n",
-       "    'fr_Ndealkylation2': 0,\n",
-       "    'fr_Nhpyrrole': 0,\n",
-       "    'fr_SH': 0,\n",
-       "    'fr_aldehyde': 0,\n",
-       "    'fr_alkyl_carbamate': 0,\n",
-       "    'fr_alkyl_halide': 0,\n",
-       "    'fr_allylic_oxid': 0,\n",
-       "    'fr_amide': 0,\n",
-       "    'fr_amidine': 0,\n",
-       "    'fr_aniline': 0,\n",
-       "    'fr_aryl_methyl': 0,\n",
-       "    'fr_azide': 0,\n",
-       "    'fr_azo': 0,\n",
-       "    'fr_barbitur': 0,\n",
-       "    'fr_benzene': 0,\n",
-       "    'fr_benzodiazepine': 0,\n",
-       "    'fr_bicyclic': 0,\n",
-       "    'fr_diazo': 0,\n",
-       "    'fr_dihydropyridine': 0,\n",
-       "    'fr_epoxide': 0,\n",
-       "    'fr_ester': 0,\n",
-       "    'fr_ether': 0,\n",
-       "    'fr_furan': 0,\n",
-       "    'fr_guanido': 0,\n",
-       "    'fr_halogen': 0,\n",
-       "    'fr_hdrzine': 0,\n",
-       "    'fr_hdrzone': 0,\n",
-       "    'fr_imidazole': 0,\n",
-       "    'fr_imide': 0,\n",
-       "    'fr_isocyan': 0,\n",
-       "    'fr_isothiocyan': 0,\n",
-       "    'fr_ketone': 0,\n",
-       "    'fr_ketone_Topliss': 0,\n",
-       "    'fr_lactam': 0,\n",
-       "    'fr_lactone': 0,\n",
-       "    'fr_methoxy': 0,\n",
-       "    'fr_morpholine': 0,\n",
-       "    'fr_nitrile': 0,\n",
-       "    'fr_nitro': 0,\n",
-       "    'fr_nitro_arom': 0,\n",
-       "    'fr_nitro_arom_nonortho': 0,\n",
-       "    'fr_nitroso': 0,\n",
-       "    'fr_oxazole': 0,\n",
-       "    'fr_oxime': 0,\n",
-       "    'fr_para_hydroxylation': 0,\n",
-       "    'fr_phenol': 0,\n",
-       "    'fr_phenol_noOrthoHbond': 0,\n",
-       "    'fr_phos_acid': 0,\n",
-       "    'fr_phos_ester': 0,\n",
-       "    'fr_piperdine': 0,\n",
-       "    'fr_piperzine': 0,\n",
-       "    'fr_priamide': 0,\n",
-       "    'fr_prisulfonamd': 0,\n",
-       "    'fr_pyridine': 0,\n",
-       "    'fr_quatN': 0,\n",
-       "    'fr_sulfide': 0,\n",
-       "    'fr_sulfonamd': 0,\n",
-       "    'fr_sulfone': 0,\n",
-       "    'fr_term_acetylene': 0,\n",
-       "    'fr_tetrazole': 0,\n",
-       "    'fr_thiazole': 0,\n",
-       "    'fr_thiocyan': 0,\n",
-       "    'fr_thiophene': 0,\n",
-       "    'fr_unbrch_alkane': 0,\n",
-       "    'fr_urea': 0\n",
-       "}\n",
-       "
\n" - ], - "text/plain": [ - "\u001b[1m{\u001b[0m\n", - " \u001b[32m'name'\u001b[0m: \u001b[32m'short_test'\u001b[0m,\n", - " \u001b[32m'rdmol'\u001b[0m: \u001b[1m<\u001b[0m\u001b[1;95mrdkit.Chem.rdchem.Mol\u001b[0m\u001b[39m object at \u001b[0m\u001b[1;36m0x7f10c5030820\u001b[0m\u001b[1m>\u001b[0m,\n", - " \u001b[32m'coords'\u001b[0m: \u001b[1;35marray\u001b[0m\u001b[1m(\u001b[0m\u001b[1m[\u001b[0m\u001b[1m[\u001b[0m \u001b[1;36m0.9862\u001b[0m, \u001b[1;36m-0.257\u001b[0m , \u001b[1;36m-0.1905\u001b[0m\u001b[1m]\u001b[0m,\n", - " \u001b[1m[\u001b[0m\u001b[1;36m-0.2052\u001b[0m, \u001b[1;36m0.2236\u001b[0m, \u001b[1;36m0.6206\u001b[0m\u001b[1m]\u001b[0m,\n", - " \u001b[1m[\u001b[0m\u001b[1;36m-1.4201\u001b[0m, \u001b[1;36m0.2357\u001b[0m, \u001b[1;36m-0.1847\u001b[0m\u001b[1m]\u001b[0m\u001b[1m]\u001b[0m\u001b[1m)\u001b[0m,\n", - " \u001b[32m'smiles'\u001b[0m: \u001b[32m'CCN'\u001b[0m,\n", - " \u001b[32m'config'\u001b[0m: \u001b[1;35mMoleculeGraphConfig\u001b[0m\u001b[1m(\u001b[0m\u001b[33mverbose\u001b[0m=\u001b[3;91mFalse\u001b[0m, \u001b[33madd_hs\u001b[0m=\u001b[3;91mFalse\u001b[0m, \u001b[33mgenerate_conformer\u001b[0m=\u001b[3;91mFalse\u001b[0m, \n", - "\u001b[33medge_construction_functions\u001b[0m=\u001b[1m[\u001b[0m\u001b[1m<\u001b[0m\u001b[1;95mfunction\u001b[0m\u001b[39m add_fully_connected_edges at \u001b[0m\u001b[1;36m0x7f10c593f9d0\u001b[0m\u001b[1m>\u001b[0m, \n", - "\u001b[1m<\u001b[0m\u001b[1;95mfunction\u001b[0m\u001b[39m add_k_nn_edges at \u001b[0m\u001b[1;36m0x7f10c593fa60\u001b[0m\u001b[1m>\u001b[0m, \u001b[1m<\u001b[0m\u001b[1;95mfunction\u001b[0m\u001b[39m add_distance_threshold at \u001b[0m\n", - "\u001b[1;36m0x7f10c593f940\u001b[0m\u001b[1m>\u001b[0m, \u001b[1m<\u001b[0m\u001b[1;95mfunction\u001b[0m\u001b[39m add_atom_bonds at \u001b[0m\u001b[1;36m0x7f10c593f550\u001b[0m\u001b[1m>\u001b[0m\u001b[1m]\u001b[0m, \n", - "\u001b[33mnode_metadata_functions\u001b[0m=\u001b[1m[\u001b[0m\u001b[1m<\u001b[0m\u001b[1;95mfunction\u001b[0m\u001b[39m atom_type_one_hot at \u001b[0m\u001b[1;36m0x7f10c56e1f70\u001b[0m\u001b[1m>\u001b[0m\u001b[1m]\u001b[0m, \n", - "\u001b[33medge_metadata_functions\u001b[0m=\u001b[3;35mNone\u001b[0m, \u001b[33mgraph_metadata_functions\u001b[0m=\u001b[1m[\u001b[0m\u001b[1m<\u001b[0m\u001b[1;95mfunction\u001b[0m\u001b[39m mol_descriptors at \u001b[0m\n", - "\u001b[1;36m0x7f10c5945280\u001b[0m\u001b[1m>\u001b[0m\u001b[1m]\u001b[0m\u001b[1m)\u001b[0m,\n", - " \u001b[32m'MaxEStateIndex'\u001b[0m: \u001b[1;36m4.847222222222222\u001b[0m,\n", - " \u001b[32m'MinEStateIndex'\u001b[0m: \u001b[1;36m0.75\u001b[0m,\n", - " \u001b[32m'MaxAbsEStateIndex'\u001b[0m: \u001b[1;36m4.847222222222222\u001b[0m,\n", - " \u001b[32m'MinAbsEStateIndex'\u001b[0m: \u001b[1;36m0.75\u001b[0m,\n", - " \u001b[32m'qed'\u001b[0m: \u001b[1;36m0.40623709538988323\u001b[0m,\n", - " \u001b[32m'MolWt'\u001b[0m: \u001b[1;36m45.084999999999994\u001b[0m,\n", - " \u001b[32m'HeavyAtomMolWt'\u001b[0m: \u001b[1;36m38.028999999999996\u001b[0m,\n", - " \u001b[32m'ExactMolWt'\u001b[0m: \u001b[1;36m45.057849223999995\u001b[0m,\n", - " \u001b[32m'NumValenceElectrons'\u001b[0m: \u001b[1;36m20\u001b[0m,\n", - " \u001b[32m'NumRadicalElectrons'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", - " \u001b[32m'MaxPartialCharge'\u001b[0m: \u001b[1;36m-0.010576265829206462\u001b[0m,\n", - " \u001b[32m'MinPartialCharge'\u001b[0m: \u001b[1;36m-0.3307484184390755\u001b[0m,\n", - " \u001b[32m'MaxAbsPartialCharge'\u001b[0m: \u001b[1;36m0.3307484184390755\u001b[0m,\n", - " \u001b[32m'MinAbsPartialCharge'\u001b[0m: \u001b[1;36m0.010576265829206462\u001b[0m,\n", - " \u001b[32m'FpDensityMorgan1'\u001b[0m: \u001b[1;36m2.0\u001b[0m,\n", - " \u001b[32m'FpDensityMorgan2'\u001b[0m: \u001b[1;36m2.0\u001b[0m,\n", - " \u001b[32m'FpDensityMorgan3'\u001b[0m: \u001b[1;36m2.0\u001b[0m,\n", - " \u001b[32m'BalabanJ'\u001b[0m: \u001b[1;36m1.6329931618554523\u001b[0m,\n", - " \u001b[32m'BertzCT'\u001b[0m: \u001b[1;36m2.7548875021634682\u001b[0m,\n", - " \u001b[32m'Chi0'\u001b[0m: \u001b[1;36m2.7071067811865475\u001b[0m,\n", - " \u001b[32m'Chi0n'\u001b[0m: \u001b[1;36m2.284457050376173\u001b[0m,\n", - " \u001b[32m'Chi0v'\u001b[0m: \u001b[1;36m2.284457050376173\u001b[0m,\n", - " \u001b[32m'Chi1'\u001b[0m: \u001b[1;36m1.4142135623730951\u001b[0m,\n", - " \u001b[32m'Chi1n'\u001b[0m: \u001b[1;36m1.1153550716504106\u001b[0m,\n", - " \u001b[32m'Chi1v'\u001b[0m: \u001b[1;36m1.1153550716504106\u001b[0m,\n", - " \u001b[32m'Chi2n'\u001b[0m: \u001b[1;36m0.408248290463863\u001b[0m,\n", - " \u001b[32m'Chi2v'\u001b[0m: \u001b[1;36m0.408248290463863\u001b[0m,\n", - " \u001b[32m'Chi3n'\u001b[0m: \u001b[1;36m0.0\u001b[0m,\n", - " \u001b[32m'Chi3v'\u001b[0m: \u001b[1;36m0.0\u001b[0m,\n", - " \u001b[32m'Chi4n'\u001b[0m: \u001b[1;36m0.0\u001b[0m,\n", - " \u001b[32m'Chi4v'\u001b[0m: \u001b[1;36m0.0\u001b[0m,\n", - " \u001b[32m'HallKierAlpha'\u001b[0m: \u001b[1;36m-0.04\u001b[0m,\n", - " \u001b[32m'Ipc'\u001b[0m: \u001b[1;36m2.7548875021634682\u001b[0m,\n", - " \u001b[32m'Kappa1'\u001b[0m: \u001b[1;36m2.9600000000000004\u001b[0m,\n", - " \u001b[32m'Kappa2'\u001b[0m: \u001b[1;36m1.96\u001b[0m,\n", - " \u001b[32m'Kappa3'\u001b[0m: \u001b[1;36m1.9600000000000033\u001b[0m,\n", - " \u001b[32m'LabuteASA'\u001b[0m: \u001b[1;36m20.444083839238875\u001b[0m,\n", - " \u001b[32m'PEOE_VSA1'\u001b[0m: \u001b[1;36m5.733667477162185\u001b[0m,\n", - " \u001b[32m'PEOE_VSA10'\u001b[0m: \u001b[1;36m0.0\u001b[0m,\n", - " \u001b[32m'PEOE_VSA11'\u001b[0m: \u001b[1;36m0.0\u001b[0m,\n", - " \u001b[32m'PEOE_VSA12'\u001b[0m: \u001b[1;36m0.0\u001b[0m,\n", - " \u001b[32m'PEOE_VSA13'\u001b[0m: \u001b[1;36m0.0\u001b[0m,\n", - " \u001b[32m'PEOE_VSA14'\u001b[0m: \u001b[1;36m0.0\u001b[0m,\n", - " \u001b[32m'PEOE_VSA2'\u001b[0m: \u001b[1;36m0.0\u001b[0m,\n", - " \u001b[32m'PEOE_VSA3'\u001b[0m: \u001b[1;36m0.0\u001b[0m,\n", - " \u001b[32m'PEOE_VSA4'\u001b[0m: \u001b[1;36m0.0\u001b[0m,\n", - " \u001b[32m'PEOE_VSA5'\u001b[0m: \u001b[1;36m0.0\u001b[0m,\n", - " \u001b[32m'PEOE_VSA6'\u001b[0m: \u001b[1;36m6.923737199690624\u001b[0m,\n", - " \u001b[32m'PEOE_VSA7'\u001b[0m: \u001b[1;36m6.544756405912575\u001b[0m,\n", - " \u001b[32m'PEOE_VSA8'\u001b[0m: \u001b[1;36m0.0\u001b[0m,\n", - " \u001b[32m'PEOE_VSA9'\u001b[0m: \u001b[1;36m0.0\u001b[0m,\n", - " \u001b[32m'SMR_VSA1'\u001b[0m: \u001b[1;36m0.0\u001b[0m,\n", - " \u001b[32m'SMR_VSA10'\u001b[0m: \u001b[1;36m0.0\u001b[0m,\n", - " \u001b[32m'SMR_VSA2'\u001b[0m: \u001b[1;36m0.0\u001b[0m,\n", - " \u001b[32m'SMR_VSA3'\u001b[0m: \u001b[1;36m0.0\u001b[0m,\n", - " \u001b[32m'SMR_VSA4'\u001b[0m: \u001b[1;36m5.733667477162185\u001b[0m,\n", - " \u001b[32m'SMR_VSA5'\u001b[0m: \u001b[1;36m6.923737199690624\u001b[0m,\n", - " \u001b[32m'SMR_VSA6'\u001b[0m: \u001b[1;36m6.544756405912575\u001b[0m,\n", - " \u001b[32m'SMR_VSA7'\u001b[0m: \u001b[1;36m0.0\u001b[0m,\n", - " \u001b[32m'SMR_VSA8'\u001b[0m: \u001b[1;36m0.0\u001b[0m,\n", - " \u001b[32m'SMR_VSA9'\u001b[0m: \u001b[1;36m0.0\u001b[0m,\n", - " \u001b[32m'SlogP_VSA1'\u001b[0m: \u001b[1;36m5.733667477162185\u001b[0m,\n", - " \u001b[32m'SlogP_VSA10'\u001b[0m: \u001b[1;36m0.0\u001b[0m,\n", - " \u001b[32m'SlogP_VSA11'\u001b[0m: \u001b[1;36m0.0\u001b[0m,\n", - " \u001b[32m'SlogP_VSA12'\u001b[0m: \u001b[1;36m0.0\u001b[0m,\n", - " \u001b[32m'SlogP_VSA2'\u001b[0m: \u001b[1;36m6.544756405912575\u001b[0m,\n", - " \u001b[32m'SlogP_VSA3'\u001b[0m: \u001b[1;36m0.0\u001b[0m,\n", - " \u001b[32m'SlogP_VSA4'\u001b[0m: \u001b[1;36m0.0\u001b[0m,\n", - " \u001b[32m'SlogP_VSA5'\u001b[0m: \u001b[1;36m6.923737199690624\u001b[0m,\n", - " \u001b[32m'SlogP_VSA6'\u001b[0m: \u001b[1;36m0.0\u001b[0m,\n", - " \u001b[32m'SlogP_VSA7'\u001b[0m: \u001b[1;36m0.0\u001b[0m,\n", - " \u001b[32m'SlogP_VSA8'\u001b[0m: \u001b[1;36m0.0\u001b[0m,\n", - " \u001b[32m'SlogP_VSA9'\u001b[0m: \u001b[1;36m0.0\u001b[0m,\n", - " \u001b[32m'TPSA'\u001b[0m: \u001b[1;36m26.02\u001b[0m,\n", - " \u001b[32m'EState_VSA1'\u001b[0m: \u001b[1;36m0.0\u001b[0m,\n", - " \u001b[32m'EState_VSA10'\u001b[0m: \u001b[1;36m0.0\u001b[0m,\n", - " \u001b[32m'EState_VSA11'\u001b[0m: \u001b[1;36m0.0\u001b[0m,\n", - " \u001b[32m'EState_VSA2'\u001b[0m: \u001b[1;36m0.0\u001b[0m,\n", - " \u001b[32m'EState_VSA3'\u001b[0m: \u001b[1;36m0.0\u001b[0m,\n", - " \u001b[32m'EState_VSA4'\u001b[0m: \u001b[1;36m6.544756405912575\u001b[0m,\n", - " \u001b[32m'EState_VSA5'\u001b[0m: \u001b[1;36m0.0\u001b[0m,\n", - " \u001b[32m'EState_VSA6'\u001b[0m: \u001b[1;36m0.0\u001b[0m,\n", - " \u001b[32m'EState_VSA7'\u001b[0m: \u001b[1;36m6.923737199690624\u001b[0m,\n", - " \u001b[32m'EState_VSA8'\u001b[0m: \u001b[1;36m0.0\u001b[0m,\n", - " \u001b[32m'EState_VSA9'\u001b[0m: \u001b[1;36m5.733667477162185\u001b[0m,\n", - " \u001b[32m'VSA_EState1'\u001b[0m: \u001b[1;36m0.0\u001b[0m,\n", - " \u001b[32m'VSA_EState10'\u001b[0m: \u001b[1;36m0.0\u001b[0m,\n", - " \u001b[32m'VSA_EState2'\u001b[0m: \u001b[1;36m0.0\u001b[0m,\n", - " \u001b[32m'VSA_EState3'\u001b[0m: \u001b[1;36m0.0\u001b[0m,\n", - " \u001b[32m'VSA_EState4'\u001b[0m: \u001b[1;36m4.847222222222222\u001b[0m,\n", - " \u001b[32m'VSA_EState5'\u001b[0m: \u001b[1;36m0.0\u001b[0m,\n", - " \u001b[32m'VSA_EState6'\u001b[0m: \u001b[1;36m0.0\u001b[0m,\n", - " \u001b[32m'VSA_EState7'\u001b[0m: \u001b[1;36m0.0\u001b[0m,\n", - " \u001b[32m'VSA_EState8'\u001b[0m: \u001b[1;36m2.6527777777777777\u001b[0m,\n", - " \u001b[32m'VSA_EState9'\u001b[0m: \u001b[1;36m0.0\u001b[0m,\n", - " \u001b[32m'FractionCSP3'\u001b[0m: \u001b[1;36m1.0\u001b[0m,\n", - " \u001b[32m'HeavyAtomCount'\u001b[0m: \u001b[1;36m3\u001b[0m,\n", - " \u001b[32m'NHOHCount'\u001b[0m: \u001b[1;36m2\u001b[0m,\n", - " \u001b[32m'NOCount'\u001b[0m: \u001b[1;36m1\u001b[0m,\n", - " \u001b[32m'NumAliphaticCarbocycles'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", - " \u001b[32m'NumAliphaticHeterocycles'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", - " \u001b[32m'NumAliphaticRings'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", - " \u001b[32m'NumAromaticCarbocycles'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", - " \u001b[32m'NumAromaticHeterocycles'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", - " \u001b[32m'NumAromaticRings'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", - " \u001b[32m'NumHAcceptors'\u001b[0m: \u001b[1;36m1\u001b[0m,\n", - " \u001b[32m'NumHDonors'\u001b[0m: \u001b[1;36m1\u001b[0m,\n", - " \u001b[32m'NumHeteroatoms'\u001b[0m: \u001b[1;36m1\u001b[0m,\n", - " \u001b[32m'NumRotatableBonds'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", - " \u001b[32m'NumSaturatedCarbocycles'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", - " \u001b[32m'NumSaturatedHeterocycles'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", - " \u001b[32m'NumSaturatedRings'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", - " \u001b[32m'RingCount'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", - " \u001b[32m'MolLogP'\u001b[0m: \u001b[1;36m-0.03499999999999981\u001b[0m,\n", - " \u001b[32m'MolMR'\u001b[0m: \u001b[1;36m14.728400000000002\u001b[0m,\n", - " \u001b[32m'fr_Al_COO'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", - " \u001b[32m'fr_Al_OH'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", - " \u001b[32m'fr_Al_OH_noTert'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", - " \u001b[32m'fr_ArN'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", - " \u001b[32m'fr_Ar_COO'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", - " \u001b[32m'fr_Ar_N'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", - " \u001b[32m'fr_Ar_NH'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", - " \u001b[32m'fr_Ar_OH'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", - " \u001b[32m'fr_COO'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", - " \u001b[32m'fr_COO2'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", - " \u001b[32m'fr_C_O'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", - " \u001b[32m'fr_C_O_noCOO'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", - " \u001b[32m'fr_C_S'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", - " \u001b[32m'fr_HOCCN'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", - " \u001b[32m'fr_Imine'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", - " \u001b[32m'fr_NH0'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", - " \u001b[32m'fr_NH1'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", - " \u001b[32m'fr_NH2'\u001b[0m: \u001b[1;36m1\u001b[0m,\n", - " \u001b[32m'fr_N_O'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", - " \u001b[32m'fr_Ndealkylation1'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", - " \u001b[32m'fr_Ndealkylation2'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", - " \u001b[32m'fr_Nhpyrrole'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", - " \u001b[32m'fr_SH'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", - " \u001b[32m'fr_aldehyde'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", - " \u001b[32m'fr_alkyl_carbamate'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", - " \u001b[32m'fr_alkyl_halide'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", - " \u001b[32m'fr_allylic_oxid'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", - " \u001b[32m'fr_amide'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", - " \u001b[32m'fr_amidine'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", - " \u001b[32m'fr_aniline'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", - " \u001b[32m'fr_aryl_methyl'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", - " \u001b[32m'fr_azide'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", - " \u001b[32m'fr_azo'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", - " \u001b[32m'fr_barbitur'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", - " \u001b[32m'fr_benzene'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", - " \u001b[32m'fr_benzodiazepine'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", - " \u001b[32m'fr_bicyclic'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", - " \u001b[32m'fr_diazo'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", - " \u001b[32m'fr_dihydropyridine'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", - " \u001b[32m'fr_epoxide'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", - " \u001b[32m'fr_ester'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", - " \u001b[32m'fr_ether'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", - " \u001b[32m'fr_furan'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", - " \u001b[32m'fr_guanido'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", - " \u001b[32m'fr_halogen'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", - " \u001b[32m'fr_hdrzine'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", - " \u001b[32m'fr_hdrzone'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", - " \u001b[32m'fr_imidazole'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", - " \u001b[32m'fr_imide'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", - " \u001b[32m'fr_isocyan'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", - " \u001b[32m'fr_isothiocyan'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", - " \u001b[32m'fr_ketone'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", - " \u001b[32m'fr_ketone_Topliss'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", - " \u001b[32m'fr_lactam'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", - " \u001b[32m'fr_lactone'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", - " \u001b[32m'fr_methoxy'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", - " \u001b[32m'fr_morpholine'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", - " \u001b[32m'fr_nitrile'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", - " \u001b[32m'fr_nitro'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", - " \u001b[32m'fr_nitro_arom'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", - " \u001b[32m'fr_nitro_arom_nonortho'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", - " \u001b[32m'fr_nitroso'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", - " \u001b[32m'fr_oxazole'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", - " \u001b[32m'fr_oxime'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", - " \u001b[32m'fr_para_hydroxylation'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", - " \u001b[32m'fr_phenol'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", - " \u001b[32m'fr_phenol_noOrthoHbond'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", - " \u001b[32m'fr_phos_acid'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", - " \u001b[32m'fr_phos_ester'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", - " \u001b[32m'fr_piperdine'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", - " \u001b[32m'fr_piperzine'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", - " \u001b[32m'fr_priamide'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", - " \u001b[32m'fr_prisulfonamd'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", - " \u001b[32m'fr_pyridine'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", - " \u001b[32m'fr_quatN'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", - " \u001b[32m'fr_sulfide'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", - " \u001b[32m'fr_sulfonamd'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", - " \u001b[32m'fr_sulfone'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", - " \u001b[32m'fr_term_acetylene'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", - " \u001b[32m'fr_tetrazole'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", - " \u001b[32m'fr_thiazole'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", - " \u001b[32m'fr_thiocyan'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", - " \u001b[32m'fr_thiophene'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", - " \u001b[32m'fr_unbrch_alkane'\u001b[0m: \u001b[1;36m0\u001b[0m,\n", - " \u001b[32m'fr_urea'\u001b[0m: \u001b[1;36m0\u001b[0m\n", - "\u001b[1m}\u001b[0m\n" - ] + "orig_nbformat": 4 }, - "metadata": {}, - "output_type": "display_data" - } - ], - "source": [ - "config = gm.MoleculeGraphConfig(\n", - " graph_metadata_functions=[\n", - " gm.mol_descriptors\n", - " ]\n", - ")\n", - "graph = gm.construct_graph(path=\"../tests/molecule/test_data/short_test.mol2\", config=config)\n", - "\n", - "print(graph.graph)" - ] - }, - { - "cell_type": "code", - "execution_count": null, - "metadata": {}, - "outputs": [], - "source": [] - } - ], - "metadata": { - "interpreter": { - "hash": "18b92dcb3aeecaafcda3e696c227fe0e653d0ebba9b1df5f8e7485b6c09cf261" - }, - "kernelspec": { - "display_name": "Python 3.8.10 ('graphein-dev-test')", - "language": "python", - "name": "python3" - }, - "language_info": { - "codemirror_mode": { - "name": "ipython", - "version": 3 - }, - "file_extension": ".py", - "mimetype": "text/x-python", - "name": "python", - "nbconvert_exporter": "python", - "pygments_lexer": "ipython3", - "version": "3.8.10" - }, - "orig_nbformat": 4 - }, - "nbformat": 4, - "nbformat_minor": 2 -} + "nbformat": 4, + "nbformat_minor": 2 +} \ No newline at end of file diff --git a/notebooks/molecule_utils.ipynb b/notebooks/molecule_utils.ipynb new file mode 100644 index 00000000..fb6e66be --- /dev/null +++ b/notebooks/molecule_utils.ipynb @@ -0,0 +1,16458 @@ +{ + "cells": [ + { + "cell_type": "markdown", + "metadata": {}, + "source": [ + "# Utilities for working with Molecular Graphs\n", + "\n", + "Graphein wraps a lot of RDKit utilities and convenience functions. These can operate on both nx.Graph and normal RDKit Mols." + ] + }, + { + "cell_type": "code", + "execution_count": 3, + "metadata": {}, + "outputs": [], + "source": [ + "# Install graphein if necessary\n", + "#!pip install graphein" + ] + }, + { + "cell_type": "code", + "execution_count": 4, + "metadata": {}, + "outputs": [ + { + "data": { + "image/png": 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", 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"source": [ + "gm.plotly_molecular_graph(g)" + ] + }, + { + "cell_type": "markdown", + "metadata": {}, + "source": [ + "## Fragments\n", + "### Counting Fragments" + ] + }, + { + "cell_type": "code", + "execution_count": 12, + "metadata": {}, + "outputs": [ + { + "data": { + "text/plain": [ + "1" + ] + }, + "execution_count": 12, + "metadata": {}, + "output_type": "execute_result" + } + ], + "source": [ + "utils.count_fragments(g)" + ] + }, + { + "cell_type": "markdown", + "metadata": {}, + "source": [ + "## Geometry\n", + "\n", + "### Computing the center of a molecule\n", + "We can compute the centroid of a given conformation using: # TODO\n" + ] + }, + { + "cell_type": "code", + "execution_count": 10, + "metadata": {}, + "outputs": [ + { + "data": { + "text/plain": [ + "array([-0.69532484, 0.09425642, 0.12058584])" + ] + }, + "execution_count": 10, + "metadata": {}, + "output_type": "execute_result" + } + ], + "source": [ + "utils.get_center(g)" + ] + }, + { + "cell_type": "markdown", + "metadata": {}, + "source": [ + "### Computing Moments of Inertia" + ] + }, + { + "cell_type": "code", + "execution_count": 11, + "metadata": {}, + "outputs": [ + { + "data": { + "text/plain": [ + "(0.11697174259640879, 0.9956246683655998)" + ] + }, + "execution_count": 11, + "metadata": {}, + "output_type": "execute_result" + } + ], + "source": [ + "utils.get_shape_moments(g)" + ] + }, + { + "cell_type": "markdown", + "metadata": {}, + "source": [ + "## Fingerprints" + ] + }, + { + "cell_type": "code", + "execution_count": 14, + "metadata": {}, + "outputs": [ + { + "data": { + "text/plain": [ + "" + ] + }, + "execution_count": 14, + "metadata": {}, + "output_type": "execute_result" + } + ], + "source": [ + "utils.get_morgan_fp(g)" + ] + }, + { + "cell_type": "code", + "execution_count": 15, + "metadata": {}, + "outputs": [ + { + "data": { + "text/plain": [ + "array([0, 0, 0, ..., 0, 0, 0], dtype=int8)" + ] + }, + "execution_count": 15, + "metadata": {}, + "output_type": "execute_result" + } + ], + "source": [ + "utils.get_morgan_fp_np(g, radius=2, n_bits=2048)" + ] + }, + { + "cell_type": "markdown", + "metadata": {}, + "source": [ + "## Rings\n", + "### Get size of largest ring" + ] + }, + { + "cell_type": "code", + "execution_count": 13, + "metadata": {}, + "outputs": [ + { + "data": { + "text/plain": [ + "6" + ] + }, + "execution_count": 13, + "metadata": {}, + "output_type": "execute_result" + } + ], + "source": [ + "utils.get_max_ring_size(g)" + ] + }, + { + "cell_type": "markdown", + "metadata": {}, + "source": [ + "## Scores\n", + "### QED - Quantitative Estimate of Druglikeness" + ] + }, + { + "cell_type": "code", + "execution_count": 3, + "metadata": {}, + "outputs": [ + { + "data": { + "text/plain": [ + "0.7166041254699328" + ] + }, + "execution_count": 3, + "metadata": {}, + "output_type": "execute_result" + } + ], + "source": [ + "utils.get_qed_score(g)" + ] + }, + { + "cell_type": "markdown", + "metadata": {}, + "source": [ + "## String Representations" + ] + }, + { + "cell_type": "code", + "execution_count": 5, + "metadata": {}, + "outputs": [ + { + "data": { + "text/plain": [ + "'CC1=C(C)C2=C(CCC(C)(COC3=CC=C(CC4SC(=O)NC4=O)C=C3)O2)C(C)=C1O'" + ] + }, + "execution_count": 5, + "metadata": {}, + "output_type": "execute_result" + } + ], + "source": [ + "# Mol / Graph -> SMILES\n", + "smiles = utils.get_smiles(g)\n", + "smiles" + ] + }, + { + "cell_type": "code", + "execution_count": 4, + "metadata": {}, + "outputs": [ + { + "data": { + "image/png": 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", + "text/plain": [ + "" + ] + }, + "execution_count": 4, + "metadata": {}, + "output_type": "execute_result" + } + ], + "source": [ + "# SMILES -> Mol\n", + "utils.get_mol(smiles)" + ] + } + ], + "metadata": { + "interpreter": { + "hash": "0ab7f988027852efc1ebacd06db3f130eb65d2a20cb6a366311359132c20a952" + }, + "kernelspec": { + "display_name": "Python 3.8.13 ('graphein')", + "language": "python", + "name": "python3" + }, + "language_info": { + "codemirror_mode": { + "name": "ipython", + "version": 3 + }, + "file_extension": ".py", + "mimetype": "text/x-python", + "name": "python", + "nbconvert_exporter": "python", + "pygments_lexer": "ipython3", + "version": "3.8.13" + }, + "orig_nbformat": 4 + }, + "nbformat": 4, + "nbformat_minor": 2 +} diff --git a/notebooks/molecules_from_zinc_and_chembl.ipynb b/notebooks/molecules_from_zinc_and_chembl.ipynb new file mode 100644 index 00000000..3a0fe2a3 --- /dev/null +++ b/notebooks/molecules_from_zinc_and_chembl.ipynb @@ -0,0 +1,2475 @@ +{ + "cells": [ + { + "cell_type": "markdown", + "metadata": {}, + "source": [ + "# Working with Molecules from ZINC and ChEMBL\n", + "\n", + "Graphein provides utilities for retrieving molecules and metadata from [ZINC](https://zinc.docking.org/) and [ChEMBL](https://www.ebi.ac.uk/chembl/)\n", + "\n", + "The ZINC database is a curated collection of commercially available chemical compounds prepared especially for virtual screening.\n", + "\n", + "\n", + "ChEMBL or ChEMBLdb is a manually curated chemical database of bioactive molecules with drug-like properties. It is maintained by the European Bioinformatics Institute, of the European Molecular Biology Laboratory\n", + "\n", + "[![Open In Colab](https://colab.research.google.com/assets/colab-badge.svg)](https://colab.research.google.com/github/a-r-j/graphein/blob/master/notebooks/molecules_from_zinc_and_chembl.ipynb) [![GitHub](https://img.shields.io/badge/-View%20on%20GitHub-181717?logo=github&logoColor=ffffff)](https://github.com/a-r-j/graphein/blob/master/notebooks/molecules_from_zinc_and_chembl.ipynb)" + ] + }, + { + "cell_type": "code", + "execution_count": 2, + "metadata": {}, + "outputs": [], + "source": [ + "# Install Graphein if necessary\n", + "# !pip install graphein[extras]" + ] + }, + { + "cell_type": "code", + "execution_count": 3, + "metadata": {}, + "outputs": [], + "source": [ + "import graphein.molecule as gm" + ] + }, + { + "cell_type": "markdown", + "metadata": {}, + "source": [ + "## ZINC\n", + "### Mapping between SMILEs and ZINC IDs." + ] + }, + { + "cell_type": "code", + "execution_count": 4, + "metadata": {}, + "outputs": [ + { + "data": { + "text/plain": [ + "'C[C@H]1CCCCN1CC#CC(O)(c1ccccc1)c1ccccc1'" + ] + }, + "execution_count": 4, + "metadata": {}, + "output_type": "execute_result" + } + ], + "source": [ + "#NBVAL_SKIP\n", + "gm.get_smiles_from_zinc(\"ZINC01234567\", backend=\"zinc15\") #Backend allows specification of which ZINC release to use" + ] + }, + { + "cell_type": "markdown", + "metadata": {}, + "source": [ + "We can also map a SMILE string back to ZINC identifiers. \n", + "\n", + "N.B. we may obtain multiple ZINC IDs. In the example below, we retrieve two ZINC IDs for the two enantiomers of the specified molecule" + ] + }, + { + "cell_type": "code", + "execution_count": 5, + "metadata": {}, + "outputs": [ + { + "data": { + "text/plain": [ + "['ZINC000001234567', 'ZINC000001234568']" + ] + }, + "execution_count": 5, + "metadata": {}, + "output_type": "execute_result" + } + ], + "source": [ + "#NBVAL_SKIP\n", + "gm.get_zinc_id_from_smile(\"C[C@H]1CCCCN1CC#CC(O)(c1ccccc1)c1ccccc1\")" + ] + }, + { + "cell_type": "markdown", + "metadata": {}, + "source": [ + "### Constructing Graphs\n", + "We can also retrieve the molecular graphs directly from the ZINC ID" + ] + }, + { + "cell_type": "code", + "execution_count": 6, + "metadata": {}, + "outputs": [ + { + "data": { + "image/png": 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", + "text/plain": [ + "" + ] + }, + "execution_count": 6, + "metadata": {}, + "output_type": "execute_result" + } + ], + "source": [ + "#NBVAL_SKIP\n", + "g = gm.construct_graph(zinc_id=\"ZINC000001234567\")\n", + "g.graph[\"rdmol\"]" + ] + }, + { + "cell_type": "code", + "execution_count": 8, + "metadata": {}, + "outputs": [ + { + "data": { + "image/png": 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", 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"white", + "zerolinewidth": 2 + } + } + }, + "width": 620 + } + } + }, + "metadata": {}, + "output_type": "display_data" + } + ], + "source": [ + "#NBVAL_SKIP\n", + "# Here we retrieve the above molecule, generate a 3D conformer and visualise it\n", + "config = gm.MoleculeGraphConfig(edge_construction_functions=[gm.add_atom_bonds])\n", + "\n", + "g = gm.construct_graph(zinc_id=\"ZINC000001234568\", generate_conformer=True, config=config)\n", + "gm.plotly_molecular_graph(g)" + ] + }, + { + "cell_type": "markdown", + "metadata": {}, + "source": [ + "## ChEMBL\n", + "\n", + "Similarly, we can map between ChEMBL identifiers and SMILEs. We can also add ChEMBLs rich metadata to the graph" + ] + }, + { + "cell_type": "code", + "execution_count": 6, + "metadata": {}, + "outputs": [ + { + "name": "stderr", + "output_type": "stream", + "text": [ + "\u001b[33mWARNING [bioservices:ChEMBL:119]: \u001b[0m \u001b[34mThe URL (https://www.ebi.ac.uk/chembl/api/data) provided cannot be reached.\u001b[0m\n" + ] + }, + { + "data": { + "text/plain": [ + "'CC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCN.CS(=O)(=O)O'" + ] + }, + "execution_count": 6, + "metadata": {}, + "output_type": "execute_result" + } + ], + "source": [ + "#NBVAL_SKIP\n", + "gm.get_smiles_from_chembl(\"CHEMBL1234\")" + ] + }, + { + "cell_type": "code", + "execution_count": 7, + "metadata": {}, + "outputs": [ + { + "name": "stderr", + "output_type": "stream", + "text": [ + "\u001b[33mWARNING [bioservices:ChEMBL:119]: \u001b[0m \u001b[34mThe URL (https://www.ebi.ac.uk/chembl/api/data) provided cannot be reached.\u001b[0m\n", + "\u001b[33mWARNING [bioservices:ChEMBL:119]: \u001b[0m \u001b[34mThe URL (https://www.ebi.ac.uk/chembl/api/data) provided cannot be reached.\u001b[0m\n" + ] + }, + { + "data": { + "text/plain": [ + "'CHEMBL1234'" + ] + }, + "execution_count": 7, + "metadata": {}, + "output_type": "execute_result" + } + ], + "source": [ + "#NBVAL_SKIP\n", + "gm.get_chembl_id_from_smiles(\"CC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCN.CS(=O)(=O)O\")" + ] + }, + { + "cell_type": "markdown", + "metadata": {}, + "source": [ + "### Constructing Graphs from ChEMBL" + ] + }, + { + "cell_type": "code", + "execution_count": 9, + "metadata": {}, + "outputs": [ + { + "name": "stderr", + "output_type": "stream", + "text": [ + "\u001b[33mWARNING [bioservices:ChEMBL:119]: \u001b[0m \u001b[34mThe URL (https://www.ebi.ac.uk/chembl/api/data) provided cannot be reached.\u001b[0m\n", + "\u001b[33mWARNING [bioservices:ChEMBL:119]: \u001b[0m \u001b[34mThe URL (https://www.ebi.ac.uk/chembl/api/data) provided cannot be reached.\u001b[0m\n", + "\u001b[33mWARNING [bioservices:ChEMBL:119]: \u001b[0m \u001b[34mThe URL (https://www.ebi.ac.uk/chembl/api/data) provided cannot be reached.\u001b[0m\n", + "\u001b[33mWARNING [bioservices:ChEMBL:119]: \u001b[0m \u001b[34mThe URL (https://www.ebi.ac.uk/chembl/api/data) provided cannot be reached.\u001b[0m\n" + ] + }, + { + "data": { + "image/png": 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", + "text/plain": [ + "" + ] + }, + "execution_count": 9, + "metadata": {}, + "output_type": "execute_result" + } + ], + "source": [ + "#NBVAL_SKIP\n", + "g = gm.construct_graph(chembl_id=\"CHEMBL1234\")\n", + "g.graph[\"rdmol\"]" + ] + }, + { + "cell_type": "markdown", + "metadata": {}, + "source": [ + "### Retrieving Metadata from ChEMBL\n", + "\n", + "We can retrieve metadata from chembl both functionally and via the graph construction config." + ] + }, + { + "cell_type": "code", + "execution_count": 13, + "metadata": {}, + "outputs": [ + { + "name": "stderr", + "output_type": "stream", + "text": [ + "\u001b[33mWARNING [bioservices:ChEMBL:119]: \u001b[0m \u001b[34mThe URL (https://www.ebi.ac.uk/chembl/api/data) provided cannot be reached.\u001b[0m\n", + "\u001b[33mWARNING [bioservices:ChEMBL:119]: \u001b[0m \u001b[34mThe URL (https://www.ebi.ac.uk/chembl/api/data) provided cannot be reached.\u001b[0m\n", + "\u001b[33mWARNING [bioservices:ChEMBL:119]: \u001b[0m \u001b[34mThe URL (https://www.ebi.ac.uk/chembl/api/data) provided cannot be reached.\u001b[0m\n", + "\u001b[33mWARNING [bioservices:ChEMBL:119]: \u001b[0m \u001b[34mThe URL (https://www.ebi.ac.uk/chembl/api/data) provided cannot be reached.\u001b[0m\n", + "\u001b[33mWARNING [bioservices:ChEMBL:119]: \u001b[0m \u001b[34mThe URL (https://www.ebi.ac.uk/chembl/api/data) provided cannot be reached.\u001b[0m\n", + "\u001b[33mWARNING [bioservices:ChEMBL:119]: \u001b[0m \u001b[34mThe URL (https://www.ebi.ac.uk/chembl/api/data) provided cannot be reached.\u001b[0m\n", + "\u001b[33mWARNING [bioservices:ChEMBL:119]: \u001b[0m \u001b[34mThe URL (https://www.ebi.ac.uk/chembl/api/data) provided cannot be reached.\u001b[0m\n", + "\u001b[33mWARNING [bioservices:ChEMBL:119]: \u001b[0m \u001b[34mThe URL (https://www.ebi.ac.uk/chembl/api/data) provided cannot be reached.\u001b[0m\n" + ] + }, + { + "name": "stdout", + "output_type": "stream", + "text": [ + "{'atc_classifications': [], 'availability_type': 1, 'biotherapeutic': None, 'black_box_warning': 0, 'chebi_par_id': 31460, 'chirality': 2, 'cross_references': [{'xref_id': 'deferoxamine%20mesylate', 'xref_name': 'deferoxamine mesylate', 'xref_src': 'DailyMed'}, {'xref_id': '11112937', 'xref_name': 'SID: 11112937', 'xref_src': 'PubChem'}, {'xref_id': '11533050', 'xref_name': 'SID: 11533050', 'xref_src': 'PubChem'}, {'xref_id': '124882730', 'xref_name': 'SID: 124882730', 'xref_src': 'PubChem'}, {'xref_id': '144204292', 'xref_name': 'SID: 144204292', 'xref_src': 'PubChem'}, {'xref_id': '170464752', 'xref_name': 'SID: 170464752', 'xref_src': 'PubChem'}, {'xref_id': '26747967', 'xref_name': 'SID: 26747967', 'xref_src': 'PubChem'}], 'dosed_ingredient': True, 'first_approval': 1968, 'first_in_class': 0, 'helm_notation': None, 'indication_class': 'Antidote (to iron poisoning); Chelating Agent', 'inorganic_flag': 0, 'max_phase': 4, 'molecule_chembl_id': 'CHEMBL1234', 'molecule_hierarchy': {'molecule_chembl_id': 'CHEMBL1234', 'parent_chembl_id': 'CHEMBL556'}, 'molecule_properties': {'alogp': '0.92', 'aromatic_rings': 0, 'cx_logd': '-3.64', 'cx_logp': '-3.37', 'cx_most_apka': '7.92', 'cx_most_bpka': '10.21', 'full_molformula': 'C26H52N6O11S', 'full_mwt': '656.80', 'hba': 9, 'hba_lipinski': 14, 'hbd': 6, 'hbd_lipinski': 7, 'heavy_atoms': 39, 'molecular_species': 'BASE', 'mw_freebase': '560.69', 'mw_monoisotopic': '560.3534', 'num_lipinski_ro5_violations': 3, 'num_ro5_violations': 2, 'psa': '205.84', 'qed_weighted': '0.06', 'ro3_pass': 'N', 'rtb': 23}, 'molecule_structures': {'canonical_smiles': 'CC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCN.CS(=O)(=O)O', 'molfile': '\\n RDKit 2D\\n\\n 44 42 0 0 0 0 0 0 0 0999 V2000\\n 8.4417 0.9708 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\\n 0.5667 0.5208 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\\n 7.7167 -4.3792 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\\n 10.5792 0.5708 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\\n 2.7042 0.9125 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\\n 0.5667 -0.3250 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0\\n 7.7167 0.5375 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0\\n 8.4417 -3.9750 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0\\n -0.1583 0.9250 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0\\n 8.4417 1.7833 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0\\n 7.0125 -3.9750 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0\\n 9.1542 0.5500 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\\n 1.2792 0.9250 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\\n 2.7042 1.7375 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0\\n 11.3042 0.9833 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0\\n 10.5792 -0.2542 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0\\n 3.4292 0.5000 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0\\n 2.0000 0.5000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\\n 9.8750 0.9708 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\\n 9.1667 -4.4250 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0\\n 7.7167 -0.2875 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0\\n 1.2792 -0.7250 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0\\n -1.5833 -4.0375 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0\\n 7.7167 -5.2250 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\\n 7.0125 0.9583 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\\n -0.1583 -0.7375 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\\n 8.4417 -3.1500 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\\n 4.1417 0.9250 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\\n 9.8750 -0.6542 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\\n -1.5833 -3.2125 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\\n 6.2917 0.5333 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\\n -0.1583 -1.5625 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\\n 9.1542 -2.7292 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\\n 4.8625 0.5208 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\\n 9.8750 -1.4917 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\\n -0.8625 -2.8000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\\n 5.5792 0.9375 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\\n 9.1542 -1.9042 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\\n -0.8625 -1.9750 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\\n 13.4750 -2.4292 0.0000 S 0 0 0 0 0 0 0 0 0 0 0 0\\n 13.0667 -1.7125 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0\\n 13.8667 -3.1500 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0\\n 14.1917 -2.0250 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0\\n 12.7500 -2.8250 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\\n 2 13 1 0\\n 3 8 1 0\\n 4 19 1 0\\n 5 17 1 0\\n 6 2 1 0\\n 7 1 1 0\\n 8 27 1 0\\n 9 2 2 0\\n 10 1 2 0\\n 11 3 2 0\\n 12 1 1 0\\n 13 18 1 0\\n 14 5 2 0\\n 15 4 2 0\\n 16 4 1 0\\n 17 28 1 0\\n 18 5 1 0\\n 19 12 1 0\\n 20 8 1 0\\n 21 7 1 0\\n 22 6 1 0\\n 23 30 1 0\\n 24 3 1 0\\n 25 7 1 0\\n 26 6 1 0\\n 27 33 1 0\\n 28 34 1 0\\n 29 16 1 0\\n 30 36 1 0\\n 31 25 1 0\\n 32 26 1 0\\n 33 38 1 0\\n 34 37 1 0\\n 35 29 1 0\\n 36 39 1 0\\n 37 31 1 0\\n 38 35 1 0\\n 39 32 1 0\\n 41 40 2 0\\n 42 40 2 0\\n 43 40 1 0\\n 44 40 1 0\\nM END\\n\\n> \\nCHEMBL1234\\n\\n> \\nDEFEROXAMINE MESYLATE\\n\\n', 'standard_inchi': 'InChI=1S/C25H48N6O8.CH4O3S/c1-21(32)29(37)18-9-3-6-16-27-22(33)12-14-25(36)31(39)20-10-4-7-17-28-23(34)11-13-24(35)30(38)19-8-2-5-15-26;1-5(2,3)4/h37-39H,2-20,26H2,1H3,(H,27,33)(H,28,34);1H3,(H,2,3,4)', 'standard_inchi_key': 'IDDIJAWJANBQLJ-UHFFFAOYSA-N'}, 'molecule_synonyms': [{'molecule_synonym': 'BA-33112', 'syn_type': 'RESEARCH_CODE', 'synonyms': 'BA-33112'}, {'molecule_synonym': 'Deferoxamine mesilate', 'syn_type': 'JAN', 'synonyms': 'DEFEROXAMINE MESILATE'}, {'molecule_synonym': 'Deferoxamine mesilate', 'syn_type': 'OTHER', 'synonyms': 'DEFEROXAMINE MESILATE'}, {'molecule_synonym': 'Deferoxamine mesylate', 'syn_type': 'FDA', 'synonyms': 'DEFEROXAMINE MESYLATE'}, {'molecule_synonym': 'Deferoxamine mesylate', 'syn_type': 'OTHER', 'synonyms': 'DEFEROXAMINE MESYLATE'}, {'molecule_synonym': 'Deferoxamine mesylate', 'syn_type': 'TRADE_NAME', 'synonyms': 'DEFEROXAMINE MESYLATE'}, {'molecule_synonym': 'Deferoxamine mesylate', 'syn_type': 'USAN', 'synonyms': 'DEFEROXAMINE MESYLATE'}, {'molecule_synonym': 'Deferoxamine mesylate', 'syn_type': 'USP', 'synonyms': 'DEFEROXAMINE MESYLATE'}, {'molecule_synonym': 'Deferoxamine methanesulfonate', 'syn_type': 'MERCK_INDEX', 'synonyms': 'DEFEROXAMINE METHANESULFONATE'}, {'molecule_synonym': 'Deferoxamini mesilas', 'syn_type': 'OTHER', 'synonyms': 'DEFEROXAMINI MESILAS'}, {'molecule_synonym': 'Desferal', 'syn_type': 'TRADE_NAME', 'synonyms': 'Desferal'}, {'molecule_synonym': 'Desferal Mesylate', 'syn_type': 'TRADE_NAME', 'synonyms': 'Desferal Mesylate'}, {'molecule_synonym': 'Desferrioxamine mesilate', 'syn_type': 'BAN', 'synonyms': 'DESFERRIOXAMINE MESILATE'}, {'molecule_synonym': 'Desferrioxamine mesilate', 'syn_type': 'BNF', 'synonyms': 'DESFERRIOXAMINE MESILATE'}, {'molecule_synonym': 'Desferrioxamine Mesylate', 'syn_type': 'TRADE_NAME', 'synonyms': 'Desferrioxamine Mesylate'}, {'molecule_synonym': 'Desferrioxamine mesylate', 'syn_type': 'OTHER', 'synonyms': 'DESFERRIOXAMINE MESYLATE'}, {'molecule_synonym': 'NSC-756718', 'syn_type': 'RESEARCH_CODE', 'synonyms': 'NSC-756718'}], 'molecule_type': 'Small molecule', 'natural_product': 0, 'oral': False, 'parenteral': True, 'polymer_flag': 0, 'pref_name': 'DEFEROXAMINE MESYLATE', 'prodrug': 0, 'structure_type': 'MOL', 'therapeutic_flag': True, 'topical': False, 'usan_stem': None, 'usan_stem_definition': None, 'usan_substem': None, 'usan_year': 1966, 'withdrawn_class': None, 'withdrawn_country': None, 'withdrawn_flag': False, 'withdrawn_reason': None, 'withdrawn_year': None}\n" + ] + } + ], + "source": [ + "#NBVAL_SKIP\n", + "# Functionally\n", + "\n", + "g = gm.add_chembl_metadata(g)\n", + "print(g.graph[\"chembl_metadata\"])" + ] + }, + { + "cell_type": "code", + "execution_count": 15, + "metadata": {}, + "outputs": [ + { + "name": "stderr", + "output_type": "stream", + "text": [ + "\u001b[33mWARNING [bioservices:ChEMBL:119]: \u001b[0m \u001b[34mThe URL (https://www.ebi.ac.uk/chembl/api/data) provided cannot be reached.\u001b[0m\n", + "\u001b[33mWARNING [bioservices:ChEMBL:119]: \u001b[0m \u001b[34mThe URL (https://www.ebi.ac.uk/chembl/api/data) provided cannot be reached.\u001b[0m\n", + "\u001b[33mWARNING [bioservices:ChEMBL:119]: \u001b[0m \u001b[34mThe URL (https://www.ebi.ac.uk/chembl/api/data) provided cannot be reached.\u001b[0m\n", + "\u001b[33mWARNING [bioservices:ChEMBL:119]: \u001b[0m \u001b[34mThe URL (https://www.ebi.ac.uk/chembl/api/data) provided cannot be reached.\u001b[0m\n", + "\u001b[33mWARNING [bioservices:ChEMBL:119]: \u001b[0m \u001b[34mThe URL (https://www.ebi.ac.uk/chembl/api/data) provided cannot be reached.\u001b[0m\n", + "\u001b[33mWARNING [bioservices:ChEMBL:119]: \u001b[0m \u001b[34mThe URL (https://www.ebi.ac.uk/chembl/api/data) provided cannot be reached.\u001b[0m\n", + "\u001b[33mWARNING [bioservices:ChEMBL:119]: \u001b[0m \u001b[34mThe URL (https://www.ebi.ac.uk/chembl/api/data) provided cannot be reached.\u001b[0m\n", + "\u001b[33mWARNING [bioservices:ChEMBL:119]: \u001b[0m \u001b[34mThe URL (https://www.ebi.ac.uk/chembl/api/data) provided cannot be reached.\u001b[0m\n", + "\u001b[33mWARNING [bioservices:ChEMBL:119]: \u001b[0m \u001b[34mThe URL (https://www.ebi.ac.uk/chembl/api/data) provided cannot be reached.\u001b[0m\n", + "\u001b[33mWARNING [bioservices:ChEMBL:119]: \u001b[0m \u001b[34mThe URL (https://www.ebi.ac.uk/chembl/api/data) provided cannot be reached.\u001b[0m\n", + "\u001b[33mWARNING [bioservices:ChEMBL:119]: \u001b[0m \u001b[34mThe URL (https://www.ebi.ac.uk/chembl/api/data) provided cannot be reached.\u001b[0m\n", + "\u001b[33mWARNING [bioservices:ChEMBL:119]: \u001b[0m \u001b[34mThe URL (https://www.ebi.ac.uk/chembl/api/data) provided cannot be reached.\u001b[0m\n", + "\u001b[33mWARNING [bioservices:ChEMBL:119]: \u001b[0m \u001b[34mThe URL (https://www.ebi.ac.uk/chembl/api/data) provided cannot be reached.\u001b[0m\n", + "\u001b[33mWARNING [bioservices:ChEMBL:119]: \u001b[0m \u001b[34mThe URL (https://www.ebi.ac.uk/chembl/api/data) provided cannot be reached.\u001b[0m\n", + "\u001b[33mWARNING [bioservices:ChEMBL:119]: \u001b[0m \u001b[34mThe URL (https://www.ebi.ac.uk/chembl/api/data) provided cannot be reached.\u001b[0m\n", + "\u001b[33mWARNING [bioservices:ChEMBL:119]: \u001b[0m \u001b[34mThe URL (https://www.ebi.ac.uk/chembl/api/data) provided cannot be reached.\u001b[0m\n", + "\u001b[33mWARNING [bioservices:ChEMBL:119]: \u001b[0m \u001b[34mThe URL (https://www.ebi.ac.uk/chembl/api/data) provided cannot be reached.\u001b[0m\n", + "\u001b[33mWARNING [bioservices:ChEMBL:119]: \u001b[0m \u001b[34mThe URL (https://www.ebi.ac.uk/chembl/api/data) provided cannot be reached.\u001b[0m\n", + "\u001b[33mWARNING [bioservices:ChEMBL:119]: \u001b[0m \u001b[34mThe URL (https://www.ebi.ac.uk/chembl/api/data) provided cannot be reached.\u001b[0m\n", + "\u001b[33mWARNING [bioservices:ChEMBL:119]: \u001b[0m \u001b[34mThe URL (https://www.ebi.ac.uk/chembl/api/data) provided cannot be reached.\u001b[0m\n", + "\u001b[33mWARNING [bioservices:ChEMBL:119]: \u001b[0m \u001b[34mThe URL (https://www.ebi.ac.uk/chembl/api/data) provided cannot be reached.\u001b[0m\n" + ] + }, + { + "data": { + "text/plain": [ + "{'atc_classifications': [],\n", + " 'availability_type': 1,\n", + " 'biotherapeutic': None,\n", + " 'black_box_warning': 0,\n", + " 'chebi_par_id': 31460,\n", + " 'chirality': 2,\n", + " 'cross_references': [{'xref_id': 'deferoxamine%20mesylate',\n", + " 'xref_name': 'deferoxamine mesylate',\n", + " 'xref_src': 'DailyMed'},\n", + " {'xref_id': '11112937', 'xref_name': 'SID: 11112937', 'xref_src': 'PubChem'},\n", + " {'xref_id': '11533050', 'xref_name': 'SID: 11533050', 'xref_src': 'PubChem'},\n", + " {'xref_id': '124882730',\n", + " 'xref_name': 'SID: 124882730',\n", + " 'xref_src': 'PubChem'},\n", + " {'xref_id': '144204292',\n", + " 'xref_name': 'SID: 144204292',\n", + " 'xref_src': 'PubChem'},\n", + " {'xref_id': '170464752',\n", + " 'xref_name': 'SID: 170464752',\n", + " 'xref_src': 'PubChem'},\n", + " {'xref_id': '26747967',\n", + " 'xref_name': 'SID: 26747967',\n", + " 'xref_src': 'PubChem'}],\n", + " 'dosed_ingredient': True,\n", + " 'first_approval': 1968,\n", + " 'first_in_class': 0,\n", + " 'helm_notation': None,\n", + " 'indication_class': 'Antidote (to iron poisoning); Chelating Agent',\n", + " 'inorganic_flag': 0,\n", + " 'max_phase': 4,\n", + " 'molecule_chembl_id': 'CHEMBL1234',\n", + " 'molecule_hierarchy': {'molecule_chembl_id': 'CHEMBL1234',\n", + " 'parent_chembl_id': 'CHEMBL556'},\n", + " 'molecule_properties': {'alogp': '0.92',\n", + " 'aromatic_rings': 0,\n", + " 'cx_logd': '-3.64',\n", + " 'cx_logp': '-3.37',\n", + " 'cx_most_apka': '7.92',\n", + " 'cx_most_bpka': '10.21',\n", + " 'full_molformula': 'C26H52N6O11S',\n", + " 'full_mwt': '656.80',\n", + " 'hba': 9,\n", + " 'hba_lipinski': 14,\n", + " 'hbd': 6,\n", + " 'hbd_lipinski': 7,\n", + " 'heavy_atoms': 39,\n", + " 'molecular_species': 'BASE',\n", + " 'mw_freebase': '560.69',\n", + " 'mw_monoisotopic': '560.3534',\n", + " 'num_lipinski_ro5_violations': 3,\n", + " 'num_ro5_violations': 2,\n", + " 'psa': '205.84',\n", + " 'qed_weighted': '0.06',\n", + " 'ro3_pass': 'N',\n", + " 'rtb': 23},\n", + " 'molecule_structures': {'canonical_smiles': 'CC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCN.CS(=O)(=O)O',\n", + " 'molfile': '\\n RDKit 2D\\n\\n 44 42 0 0 0 0 0 0 0 0999 V2000\\n 8.4417 0.9708 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\\n 0.5667 0.5208 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\\n 7.7167 -4.3792 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\\n 10.5792 0.5708 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\\n 2.7042 0.9125 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\\n 0.5667 -0.3250 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0\\n 7.7167 0.5375 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0\\n 8.4417 -3.9750 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0\\n -0.1583 0.9250 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0\\n 8.4417 1.7833 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0\\n 7.0125 -3.9750 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0\\n 9.1542 0.5500 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\\n 1.2792 0.9250 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\\n 2.7042 1.7375 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0\\n 11.3042 0.9833 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0\\n 10.5792 -0.2542 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0\\n 3.4292 0.5000 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0\\n 2.0000 0.5000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\\n 9.8750 0.9708 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\\n 9.1667 -4.4250 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0\\n 7.7167 -0.2875 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0\\n 1.2792 -0.7250 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0\\n -1.5833 -4.0375 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0\\n 7.7167 -5.2250 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\\n 7.0125 0.9583 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\\n -0.1583 -0.7375 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\\n 8.4417 -3.1500 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\\n 4.1417 0.9250 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\\n 9.8750 -0.6542 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\\n -1.5833 -3.2125 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\\n 6.2917 0.5333 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\\n -0.1583 -1.5625 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\\n 9.1542 -2.7292 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\\n 4.8625 0.5208 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\\n 9.8750 -1.4917 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\\n -0.8625 -2.8000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\\n 5.5792 0.9375 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\\n 9.1542 -1.9042 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\\n -0.8625 -1.9750 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\\n 13.4750 -2.4292 0.0000 S 0 0 0 0 0 0 0 0 0 0 0 0\\n 13.0667 -1.7125 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0\\n 13.8667 -3.1500 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0\\n 14.1917 -2.0250 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0\\n 12.7500 -2.8250 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\\n 2 13 1 0\\n 3 8 1 0\\n 4 19 1 0\\n 5 17 1 0\\n 6 2 1 0\\n 7 1 1 0\\n 8 27 1 0\\n 9 2 2 0\\n 10 1 2 0\\n 11 3 2 0\\n 12 1 1 0\\n 13 18 1 0\\n 14 5 2 0\\n 15 4 2 0\\n 16 4 1 0\\n 17 28 1 0\\n 18 5 1 0\\n 19 12 1 0\\n 20 8 1 0\\n 21 7 1 0\\n 22 6 1 0\\n 23 30 1 0\\n 24 3 1 0\\n 25 7 1 0\\n 26 6 1 0\\n 27 33 1 0\\n 28 34 1 0\\n 29 16 1 0\\n 30 36 1 0\\n 31 25 1 0\\n 32 26 1 0\\n 33 38 1 0\\n 34 37 1 0\\n 35 29 1 0\\n 36 39 1 0\\n 37 31 1 0\\n 38 35 1 0\\n 39 32 1 0\\n 41 40 2 0\\n 42 40 2 0\\n 43 40 1 0\\n 44 40 1 0\\nM END\\n\\n> \\nCHEMBL1234\\n\\n> \\nDEFEROXAMINE MESYLATE\\n\\n',\n", + " 'standard_inchi': 'InChI=1S/C25H48N6O8.CH4O3S/c1-21(32)29(37)18-9-3-6-16-27-22(33)12-14-25(36)31(39)20-10-4-7-17-28-23(34)11-13-24(35)30(38)19-8-2-5-15-26;1-5(2,3)4/h37-39H,2-20,26H2,1H3,(H,27,33)(H,28,34);1H3,(H,2,3,4)',\n", + " 'standard_inchi_key': 'IDDIJAWJANBQLJ-UHFFFAOYSA-N'},\n", + " 'molecule_synonyms': [{'molecule_synonym': 'BA-33112',\n", + " 'syn_type': 'RESEARCH_CODE',\n", + " 'synonyms': 'BA-33112'},\n", + " {'molecule_synonym': 'Deferoxamine mesilate',\n", + " 'syn_type': 'JAN',\n", + " 'synonyms': 'DEFEROXAMINE MESILATE'},\n", + " {'molecule_synonym': 'Deferoxamine mesilate',\n", + " 'syn_type': 'OTHER',\n", + " 'synonyms': 'DEFEROXAMINE MESILATE'},\n", + " {'molecule_synonym': 'Deferoxamine mesylate',\n", + " 'syn_type': 'FDA',\n", + " 'synonyms': 'DEFEROXAMINE MESYLATE'},\n", + " {'molecule_synonym': 'Deferoxamine mesylate',\n", + " 'syn_type': 'OTHER',\n", + " 'synonyms': 'DEFEROXAMINE MESYLATE'},\n", + " {'molecule_synonym': 'Deferoxamine mesylate',\n", + " 'syn_type': 'TRADE_NAME',\n", + " 'synonyms': 'DEFEROXAMINE MESYLATE'},\n", + " {'molecule_synonym': 'Deferoxamine mesylate',\n", + " 'syn_type': 'USAN',\n", + " 'synonyms': 'DEFEROXAMINE MESYLATE'},\n", + " {'molecule_synonym': 'Deferoxamine mesylate',\n", + " 'syn_type': 'USP',\n", + " 'synonyms': 'DEFEROXAMINE MESYLATE'},\n", + " {'molecule_synonym': 'Deferoxamine methanesulfonate',\n", + " 'syn_type': 'MERCK_INDEX',\n", + " 'synonyms': 'DEFEROXAMINE METHANESULFONATE'},\n", + " {'molecule_synonym': 'Deferoxamini mesilas',\n", + " 'syn_type': 'OTHER',\n", + " 'synonyms': 'DEFEROXAMINI MESILAS'},\n", + " {'molecule_synonym': 'Desferal',\n", + " 'syn_type': 'TRADE_NAME',\n", + " 'synonyms': 'Desferal'},\n", + " {'molecule_synonym': 'Desferal Mesylate',\n", + " 'syn_type': 'TRADE_NAME',\n", + " 'synonyms': 'Desferal Mesylate'},\n", + " {'molecule_synonym': 'Desferrioxamine mesilate',\n", + " 'syn_type': 'BAN',\n", + " 'synonyms': 'DESFERRIOXAMINE MESILATE'},\n", + " {'molecule_synonym': 'Desferrioxamine mesilate',\n", + " 'syn_type': 'BNF',\n", + " 'synonyms': 'DESFERRIOXAMINE MESILATE'},\n", + " {'molecule_synonym': 'Desferrioxamine Mesylate',\n", + " 'syn_type': 'TRADE_NAME',\n", + " 'synonyms': 'Desferrioxamine Mesylate'},\n", + " {'molecule_synonym': 'Desferrioxamine mesylate',\n", + " 'syn_type': 'OTHER',\n", + " 'synonyms': 'DESFERRIOXAMINE MESYLATE'},\n", + " {'molecule_synonym': 'NSC-756718',\n", + " 'syn_type': 'RESEARCH_CODE',\n", + " 'synonyms': 'NSC-756718'}],\n", + " 'molecule_type': 'Small molecule',\n", + " 'natural_product': 0,\n", + " 'oral': False,\n", + " 'parenteral': True,\n", + " 'polymer_flag': 0,\n", + " 'pref_name': 'DEFEROXAMINE MESYLATE',\n", + " 'prodrug': 0,\n", + " 'structure_type': 'MOL',\n", + " 'therapeutic_flag': True,\n", + " 'topical': False,\n", + " 'usan_stem': None,\n", + " 'usan_stem_definition': None,\n", + " 'usan_substem': None,\n", + " 'usan_year': 1966,\n", + " 'withdrawn_class': None,\n", + " 'withdrawn_country': None,\n", + " 'withdrawn_flag': False,\n", + " 'withdrawn_reason': None,\n", + " 'withdrawn_year': None}" + ] + }, + "execution_count": 15, + "metadata": {}, + "output_type": "execute_result" + } + ], + "source": [ + "# Via Config\n", + "config = gm.MoleculeGraphConfig(graph_metadata_functions=[gm.add_chembl_metadata])\n", + "g = gm.construct_graph(chembl_id=\"CHEMBL1234\", config=config)\n", + "g.graph[\"chembl_metadata\"]" + ] + } + ], + "metadata": { + "kernelspec": { + "display_name": "Python 3.8.12 ('graphein-wip')", + "language": "python", + "name": "python3" + }, + "language_info": { + "codemirror_mode": { + "name": "ipython", + "version": 3 + }, + "file_extension": ".py", + "mimetype": "text/x-python", + "name": "python", + "nbconvert_exporter": "python", + "pygments_lexer": "ipython3", + "version": "3.8.13" + }, + "orig_nbformat": 4, + "vscode": { + "interpreter": { + "hash": "2084dd4fc0c9f9186ef9bb5d9f5c6652432726a285d6ac2dcf2b1a616ab39cbb" + } + } + }, + "nbformat": 4, + "nbformat_minor": 2 +} diff --git a/notebooks/residue_graphs.ipynb b/notebooks/residue_graphs.ipynb index 2318adbe..ff4f3486 100644 --- a/notebooks/residue_graphs.ipynb +++ b/notebooks/residue_graphs.ipynb @@ -8,12 +8,12 @@ "\n", "In this notebook, we'll run through residue-level graph construction in Graphein. We start by discsussing the config, the high-level API and spend the bulk of the tutorial running through the various options. At the end we'll see how the low-level API can be used to control each step of the graph construction process.\n", "\n", - "[![Open In Colab](https://colab.research.google.com/assets/colab-badge.svg)](https://colab.research.google.com/github/a-r-j/graphein/blob/master/notebooks/residue_graphs.ipynb)" + "[![Open In Colab](https://colab.research.google.com/assets/colab-badge.svg)](https://colab.research.google.com/github/a-r-j/graphein/blob/master/notebooks/residue_graphs.ipynb) [![GitHub](https://img.shields.io/badge/-View%20on%20GitHub-181717?logo=github&logoColor=ffffff)](https://github.com/a-r-j/graphein/blob/master/notebooks/residue_graphs.ipynb)" ] }, { "cell_type": "code", - "execution_count": 3, + "execution_count": 1, "metadata": {}, "outputs": [], "source": [ @@ -28,7 +28,7 @@ "cell_type": "markdown", "metadata": {}, "source": [ - "First, let's checkout the protein we'll be playing with today:" + "First, let's check out the protein we'll be playing with today:" ] }, { @@ -38,7 +38,7 @@ "outputs": [ { "data": { - "image/png": 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", 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", "text/plain": [ "" ] @@ -46,6 +46,13 @@ "execution_count": 2, "metadata": {}, "output_type": "execute_result" + }, + { + "name": "stdout", + "output_type": "stream", + "text": [ + "xml-rpc server running on host localhost, port 9124\n" + ] } ], "source": [ @@ -68,16 +75,45 @@ }, { "cell_type": "code", - "execution_count": 4, + "execution_count": 3, "metadata": {}, "outputs": [ + { + "name": "stderr", + "output_type": "stream", + "text": [ + "To use the Graphein submodule graphein.protein.visualisation, you need to install: pytorch3d \n", + "To do so, use the following command: conda install -c pytorch3d pytorch3d\n" + ] + }, + { + "data": { + "text/html": [ + "
[06/24/22 11:02:36] WARNING  To use the Graphein submodule                       meshes.py:29\n",
+       "                             graphein.protein.meshes, you need to install:                   \n",
+       "                             pytorch3d                                                       \n",
+       "                             To do so, use the following command: conda install              \n",
+       "                             -c pytorch3d pytorch3d                                          \n",
+       "
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This removes H atoms from the pdb_df dataframe\n", - "DEBUG:graphein.protein.graphs:Detected 174 total nodes\n", - "INFO:graphein.protein.edges.distance:Found: 16 aromatic-aromatic interactions\n", - "INFO:graphein.protein.edges.distance:Found 75 hbond interactions.\n", - "INFO:graphein.protein.edges.distance:Found 7 hbond interactions.\n", - "DEBUG:graphein.protein.edges.distance:1 CYS residues found. Cannot add disulfide interactions with fewer than two CYS residues.\n", - "INFO:graphein.protein.edges.distance:Found 175 ionic interactions.\n" - ] + "data": { + "text/html": [ + "
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5 rows × 22 columns

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\n", "" ], "text/plain": [ @@ -127566,24 +129825,24 @@ "6 ATOM 47 CA ALA \n", "8 ATOM 56 CA LYS \n", "\n", - " chain_id residue_number insertion ... y_coord z_coord occupancy \\\n", - "0 A 2 ... 54.615500 -0.136833 1.0 \n", - "2 A 4 ... 50.090833 -2.889667 1.0 \n", - "4 A 6 ... 51.575429 0.109000 1.0 \n", - "6 A 8 ... 46.781200 0.618800 1.0 \n", - "8 A 10 ... 51.873333 1.231222 1.0 \n", + " chain_id residue_number insertion ... z_coord occupancy b_factor \\\n", + "0 A 2 ... -0.136833 1.0 52.54 \n", + "2 A 4 ... -2.889667 1.0 47.00 \n", + "4 A 6 ... 0.109000 1.0 32.41 \n", + "6 A 8 ... 0.618800 1.0 25.67 \n", + "8 A 10 ... 1.231222 1.0 27.63 \n", "\n", - " b_factor blank_4 segment_id element_symbol charge line_idx node_id \n", - "0 52.54 C NaN 610 A:SER:2 \n", - "2 47.00 C NaN 627 A:SER:4 \n", - "4 32.41 C NaN 641 A:VAL:6 \n", - "6 25.67 C NaN 655 A:ALA:8 \n", - "8 27.63 C NaN 664 A:LYS:10 \n", + " blank_4 segment_id element_symbol charge line_idx model_id node_id \n", + "0 C NaN 610 1 A:SER:2 \n", + "2 C NaN 627 1 A:SER:4 \n", + "4 C NaN 641 1 A:VAL:6 \n", + "6 C NaN 655 1 A:ALA:8 \n", + "8 C NaN 664 1 A:LYS:10 \n", "\n", - "[5 rows x 22 columns]" + "[5 rows x 23 columns]" ] }, - "execution_count": 51, + "execution_count": 21, "metadata": {}, "output_type": "execute_result" } @@ -127607,7 +129866,7 @@ }, { "cell_type": "code", - "execution_count": 52, + "execution_count": 22, "metadata": {}, "outputs": [ { @@ -127622,7 +129881,7 @@ "from graphein.protein.graphs import initialise_graph_with_metadata, add_nodes_to_graph\n", "\n", "g = initialise_graph_with_metadata(protein_df=df, # from above cell\n", - " raw_pdb_df=raw_df.df[\"ATOM\"], # Store this for traceability\n", + " raw_pdb_df=raw_df, # Store this for traceability\n", " pdb_code = pdb_code, #and again\n", " granularity = \"centroid\" # Store this so we know what kind of graph we have\n", " )\n", @@ -127640,22 +129899,14 @@ }, { "cell_type": "code", - "execution_count": 53, + "execution_count": 23, "metadata": {}, "outputs": [ - { - "name": "stderr", - "output_type": "stream", - "text": [ - "INFO:graphein.protein.edges.distance:Found 75 hbond interactions.\n", - "INFO:graphein.protein.edges.distance:Found 7 hbond interactions.\n" - ] - }, { "name": "stdout", "output_type": "stream", "text": [ - "[('A:SER:2', 'A:PHE:3'), ('A:PHE:3', 'A:SER:4'), ('A:SER:4', 'A:ASN:5'), ('A:ASN:5', 'A:VAL:6'), ('A:VAL:6', 'A:PRO:7'), ('A:PRO:7', 'A:ALA:8'), ('A:ALA:8', 'A:GLY:9'), ('A:GLY:9', 'A:LYS:10'), ('A:LYS:10', 'A:ASP:11'), ('A:ASP:11', 'A:LEU:12'), ('A:LEU:12', 'A:PRO:13'), ('A:PRO:13', 'A:GLN:14'), ('A:GLN:14', 'A:ASP:15'), ('A:ASP:15', 'A:PHE:16'), ('A:ASP:15', 'A:ARG:87'), ('A:PHE:16', 'A:ASN:17'), ('A:ASN:17', 'A:VAL:18'), ('A:VAL:18', 'A:ILE:19'), ('A:ILE:19', 'A:ILE:20'), ('A:ILE:20', 'A:GLU:21'), ('A:GLU:21', 'A:ILE:22'), ('A:ILE:22', 'A:PRO:23'), ('A:PRO:23', 'A:ALA:24'), ('A:ALA:24', 'A:GLN:25'), ('A:GLN:25', 'A:SER:26'), ('A:SER:26', 'A:GLU:27'), ('A:GLU:27', 'A:PRO:28'), ('A:PRO:28', 'A:VAL:29'), ('A:VAL:29', 'A:LYS:30'), ('A:LYS:30', 'A:TYR:31'), ('A:TYR:31', 'A:GLU:32'), ('A:GLU:32', 'A:ALA:33'), ('A:ALA:33', 'A:ASP:34'), ('A:ASP:34', 'A:LYS:35'), ('A:LYS:35', 'A:ALA:36'), ('A:ALA:36', 'A:LEU:37'), ('A:LEU:37', 'A:GLY:38'), ('A:GLY:38', 'A:LEU:39'), ('A:LEU:39', 'A:LEU:40'), ('A:LEU:40', 'A:VAL:41'), ('A:VAL:41', 'A:VAL:42'), ('A:VAL:42', 'A:ASP:43'), ('A:ASP:43', 'A:ARG:44'), ('A:ARG:44', 'A:PHE:45'), ('A:ARG:44', 'A:LYS:149'), ('A:PHE:45', 'A:ILE:46'), ('A:ILE:46', 'A:GLY:47'), ('A:GLY:47', 'A:THR:48'), ('A:THR:48', 'A:GLY:49'), ('A:GLY:49', 'A:MET:50'), ('A:MET:50', 'A:ARG:51'), ('A:ARG:51', 'A:TYR:52'), ('A:TYR:52', 'A:PRO:53'), ('A:PRO:53', 'A:VAL:54'), ('A:VAL:54', 'A:ASN:55'), ('A:ASN:55', 'A:TYR:56'), ('A:TYR:56', 'A:GLY:57'), ('A:TYR:56', 'A:LYS:105'), ('A:TYR:56', 'A:ASP:71'), ('A:GLY:57', 'A:PHE:58'), ('A:PHE:58', 'A:ILE:59'), ('A:ILE:59', 'A:PRO:60'), ('A:PRO:60', 'A:GLN:61'), ('A:GLN:61', 'A:THR:62'), ('A:THR:62', 'A:LEU:63'), ('A:LEU:63', 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'A:LYS:143'), ('A:GLU:99', 'A:SER:100'), ('A:SER:100', 'A:GLY:101'), ('A:GLY:101', 'A:VAL:102'), ('A:VAL:102', 'A:ASP:103'), ('A:ASP:103', 'A:ALA:104'), ('A:ASP:103', 'A:LYS:105'), ('A:ALA:104', 'A:LYS:105'), ('A:LYS:105', 'A:LEU:106'), ('A:LEU:106', 'A:VAL:107'), ('A:VAL:107', 'A:ALA:108'), ('A:ALA:108', 'A:VAL:109'), ('A:VAL:109', 'A:PRO:110'), ('A:PRO:110', 'A:HIS:111'), ('A:HIS:111', 'A:ASP:112'), ('A:ASP:112', 'A:LYS:113'), ('A:LYS:113', 'A:VAL:114'), ('A:VAL:114', 'A:CYS:115'), ('A:CYS:115', 'A:PRO:116'), ('A:CYS:115', 'A:MET:117'), ('A:PRO:116', 'A:MET:117'), ('A:MET:117', 'A:THR:118'), ('A:THR:118', 'A:ALA:119'), ('A:ALA:119', 'A:ASN:120'), ('A:ASN:120', 'A:LEU:121'), ('A:LEU:121', 'A:LYS:122'), ('A:LYS:122', 'A:SER:123'), ('A:SER:123', 'A:ILE:124'), ('A:ILE:124', 'A:ASP:125'), ('A:ASP:125', 'A:ASP:126'), ('A:ASP:126', 'A:VAL:127'), ('A:VAL:127', 'A:PRO:128'), ('A:PRO:128', 'A:ALA:129'), ('A:ALA:129', 'A:TYR:130'), ('A:TYR:130', 'A:LEU:131'), ('A:LEU:131', 'A:LYS:132'), ('A:LYS:132', 'A:ASP:133'), ('A:ASP:133', 'A:GLN:134'), ('A:GLN:134', 'A:ILE:135'), ('A:ILE:135', 'A:LYS:136'), ('A:LYS:136', 'A:HIS:137'), ('A:HIS:137', 'A:PHE:138'), ('A:PHE:138', 'A:PHE:139'), ('A:PHE:139', 'A:GLU:140'), ('A:GLU:140', 'A:GLN:141'), ('A:GLN:141', 'A:TYR:142'), ('A:TYR:142', 'A:LYS:143'), ('A:LYS:143', 'A:ALA:144'), ('A:ALA:144', 'A:LEU:145'), ('A:LEU:145', 'A:GLU:146'), ('A:GLU:146', 'A:LYS:147'), ('A:LYS:147', 'A:GLY:148'), ('A:GLY:148', 'A:LYS:149'), ('A:LYS:149', 'A:TRP:150'), ('A:TRP:150', 'A:VAL:151'), ('A:VAL:151', 'A:LYS:152'), ('A:LYS:152', 'A:VAL:153'), ('A:VAL:153', 'A:GLU:154'), ('A:GLU:154', 'A:GLY:155'), ('A:GLY:155', 'A:TRP:156'), ('A:TRP:156', 'A:ASP:157'), ('A:ASP:157', 'A:GLY:158'), ('A:GLY:158', 'A:ILE:159'), ('A:ILE:159', 'A:ASP:160'), ('A:ASP:160', 'A:ALA:161'), ('A:ALA:161', 'A:ALA:162'), ('A:ALA:162', 'A:HIS:163'), ('A:HIS:163', 'A:LYS:164'), ('A:LYS:164', 'A:GLU:165'), ('A:LYS:164', 'A:ASP:168'), ('A:GLU:165', 'A:ILE:166'), ('A:ILE:166', 'A:THR:167'), ('A:THR:167', 'A:ASP:168'), ('A:ASP:168', 'A:GLY:169'), ('A:GLY:169', 'A:VAL:170'), ('A:VAL:170', 'A:ALA:171'), ('A:ALA:171', 'A:ASN:172'), ('A:ASN:172', 'A:PHE:173'), ('A:PHE:173', 'A:LYS:174'), ('A:LYS:174', 'A:LYS:175')]\n" + "[('A:SER:2', 'A:PHE:3'), ('A:PHE:3', 'A:SER:4'), ('A:SER:4', 'A:ASN:5'), ('A:ASN:5', 'A:VAL:6'), ('A:VAL:6', 'A:PRO:7'), ('A:PRO:7', 'A:ALA:8'), ('A:ALA:8', 'A:GLY:9'), ('A:GLY:9', 'A:LYS:10'), ('A:LYS:10', 'A:ASP:11'), ('A:ASP:11', 'A:LEU:12'), ('A:LEU:12', 'A:PRO:13'), ('A:PRO:13', 'A:GLN:14'), ('A:GLN:14', 'A:ASP:15'), ('A:ASP:15', 'A:PHE:16'), ('A:ASP:15', 'A:ARG:87'), ('A:PHE:16', 'A:ASN:17'), ('A:ASN:17', 'A:VAL:18'), ('A:VAL:18', 'A:ILE:19'), ('A:ILE:19', 'A:ILE:20'), ('A:ILE:20', 'A:GLU:21'), ('A:GLU:21', 'A:ILE:22'), ('A:ILE:22', 'A:PRO:23'), ('A:PRO:23', 'A:ALA:24'), ('A:ALA:24', 'A:GLN:25'), ('A:GLN:25', 'A:SER:26'), ('A:SER:26', 'A:GLU:27'), ('A:GLU:27', 'A:PRO:28'), ('A:PRO:28', 'A:VAL:29'), ('A:VAL:29', 'A:LYS:30'), ('A:LYS:30', 'A:TYR:31'), ('A:TYR:31', 'A:GLU:32'), ('A:GLU:32', 'A:ALA:33'), ('A:ALA:33', 'A:ASP:34'), ('A:ASP:34', 'A:LYS:35'), ('A:LYS:35', 'A:ALA:36'), ('A:ALA:36', 'A:LEU:37'), ('A:LEU:37', 'A:GLY:38'), ('A:GLY:38', 'A:LEU:39'), ('A:LEU:39', 'A:LEU:40'), ('A:LEU:40', 'A:VAL:41'), ('A:VAL:41', 'A:VAL:42'), ('A:VAL:42', 'A:ASP:43'), ('A:ASP:43', 'A:ARG:44'), ('A:ARG:44', 'A:PHE:45'), ('A:ARG:44', 'A:LYS:149'), ('A:PHE:45', 'A:ILE:46'), ('A:ILE:46', 'A:GLY:47'), ('A:GLY:47', 'A:THR:48'), ('A:THR:48', 'A:GLY:49'), ('A:GLY:49', 'A:MET:50'), ('A:MET:50', 'A:ARG:51'), ('A:ARG:51', 'A:TYR:52'), ('A:TYR:52', 'A:PRO:53'), ('A:PRO:53', 'A:VAL:54'), ('A:VAL:54', 'A:ASN:55'), ('A:ASN:55', 'A:TYR:56'), ('A:TYR:56', 'A:GLY:57'), ('A:TYR:56', 'A:ASP:71'), ('A:TYR:56', 'A:LYS:105'), ('A:GLY:57', 'A:PHE:58'), ('A:PHE:58', 'A:ILE:59'), ('A:ILE:59', 'A:PRO:60'), ('A:PRO:60', 'A:GLN:61'), ('A:GLN:61', 'A:THR:62'), ('A:THR:62', 'A:LEU:63'), ('A:LEU:63', 'A:SER:64'), ('A:SER:64', 'A:GLY:65'), ('A:GLY:65', 'A:ASP:66'), ('A:ASP:66', 'A:GLY:67'), ('A:GLY:67', 'A:ASP:68'), ('A:ASP:68', 'A:PRO:69'), ('A:PRO:69', 'A:VAL:70'), ('A:VAL:70', 'A:ASP:71'), ('A:ASP:71', 'A:VAL:72'), ('A:ASP:71', 'A:LYS:105'), ('A:VAL:72', 'A:LEU:73'), ('A:LEU:73', 'A:VAL:74'), ('A:VAL:74', 'A:ILE:75'), ('A:ILE:75', 'A:THR:76'), ('A:THR:76', 'A:PRO:77'), ('A:PRO:77', 'A:PHE:78'), ('A:PHE:78', 'A:PRO:79'), ('A:PRO:79', 'A:LEU:80'), ('A:LEU:80', 'A:LEU:81'), ('A:LEU:81', 'A:ALA:82'), ('A:ALA:82', 'A:GLY:83'), ('A:GLY:83', 'A:SER:84'), ('A:SER:84', 'A:VAL:85'), ('A:VAL:85', 'A:VAL:86'), ('A:VAL:86', 'A:ARG:87'), ('A:ARG:87', 'A:ALA:88'), ('A:ALA:88', 'A:ARG:89'), ('A:ARG:89', 'A:ALA:90'), ('A:ARG:89', 'A:ASP:112'), ('A:ALA:90', 'A:LEU:91'), ('A:LEU:91', 'A:GLY:92'), ('A:GLY:92', 'A:MET:93'), ('A:MET:93', 'A:LEU:94'), ('A:LEU:94', 'A:LYS:95'), ('A:LYS:95', 'A:MET:96'), ('A:MET:96', 'A:THR:97'), ('A:THR:97', 'A:ASP:98'), ('A:ASP:98', 'A:GLU:99'), ('A:ASP:98', 'A:LYS:143'), ('A:GLU:99', 'A:SER:100'), ('A:SER:100', 'A:GLY:101'), ('A:GLY:101', 'A:VAL:102'), ('A:VAL:102', 'A:ASP:103'), ('A:ASP:103', 'A:ALA:104'), ('A:ASP:103', 'A:LYS:105'), ('A:ALA:104', 'A:LYS:105'), ('A:LYS:105', 'A:LEU:106'), ('A:LEU:106', 'A:VAL:107'), ('A:VAL:107', 'A:ALA:108'), ('A:ALA:108', 'A:VAL:109'), ('A:VAL:109', 'A:PRO:110'), ('A:PRO:110', 'A:HIS:111'), ('A:HIS:111', 'A:ASP:112'), ('A:ASP:112', 'A:LYS:113'), ('A:LYS:113', 'A:VAL:114'), ('A:VAL:114', 'A:CYS:115'), ('A:CYS:115', 'A:PRO:116'), ('A:CYS:115', 'A:MET:117'), ('A:PRO:116', 'A:MET:117'), ('A:MET:117', 'A:THR:118'), ('A:THR:118', 'A:ALA:119'), ('A:ALA:119', 'A:ASN:120'), ('A:ASN:120', 'A:LEU:121'), ('A:LEU:121', 'A:LYS:122'), ('A:LYS:122', 'A:SER:123'), ('A:SER:123', 'A:ILE:124'), ('A:ILE:124', 'A:ASP:125'), ('A:ASP:125', 'A:ASP:126'), ('A:ASP:126', 'A:VAL:127'), ('A:VAL:127', 'A:PRO:128'), ('A:PRO:128', 'A:ALA:129'), ('A:ALA:129', 'A:TYR:130'), ('A:TYR:130', 'A:LEU:131'), ('A:LEU:131', 'A:LYS:132'), ('A:LYS:132', 'A:ASP:133'), ('A:ASP:133', 'A:GLN:134'), ('A:GLN:134', 'A:ILE:135'), ('A:ILE:135', 'A:LYS:136'), ('A:LYS:136', 'A:HIS:137'), ('A:HIS:137', 'A:PHE:138'), ('A:PHE:138', 'A:PHE:139'), ('A:PHE:139', 'A:GLU:140'), ('A:GLU:140', 'A:GLN:141'), ('A:GLN:141', 'A:TYR:142'), ('A:TYR:142', 'A:LYS:143'), ('A:LYS:143', 'A:ALA:144'), ('A:ALA:144', 'A:LEU:145'), ('A:LEU:145', 'A:GLU:146'), ('A:GLU:146', 'A:LYS:147'), ('A:LYS:147', 'A:GLY:148'), ('A:GLY:148', 'A:LYS:149'), ('A:LYS:149', 'A:TRP:150'), ('A:TRP:150', 'A:VAL:151'), ('A:VAL:151', 'A:LYS:152'), ('A:LYS:152', 'A:VAL:153'), ('A:VAL:153', 'A:GLU:154'), ('A:GLU:154', 'A:GLY:155'), ('A:GLY:155', 'A:TRP:156'), ('A:TRP:156', 'A:ASP:157'), ('A:ASP:157', 'A:GLY:158'), ('A:GLY:158', 'A:ILE:159'), ('A:ILE:159', 'A:ASP:160'), ('A:ASP:160', 'A:ALA:161'), ('A:ALA:161', 'A:ALA:162'), ('A:ALA:162', 'A:HIS:163'), ('A:HIS:163', 'A:LYS:164'), ('A:LYS:164', 'A:GLU:165'), ('A:LYS:164', 'A:ASP:168'), ('A:GLU:165', 'A:ILE:166'), ('A:ILE:166', 'A:THR:167'), ('A:THR:167', 'A:ASP:168'), ('A:ASP:168', 'A:GLY:169'), ('A:GLY:169', 'A:VAL:170'), ('A:VAL:170', 'A:ALA:171'), ('A:ALA:171', 'A:ASN:172'), ('A:ASN:172', 'A:PHE:173'), ('A:PHE:173', 'A:LYS:174'), ('A:LYS:174', 'A:LYS:175')]\n" ] } ], @@ -127674,7 +129925,7 @@ }, { "cell_type": "code", - "execution_count": 55, + "execution_count": 24, "metadata": {}, "outputs": [ { @@ -127888,25 +130139,25 @@ ], [ 0.399411, - 8.59E-4, + 0.000859, 0.656133, 1 ], [ 0.41158, - 5.77E-4, + 0.000577, 0.65773, 1 ], [ 0.417642, - 5.64E-4, + 0.000564, 0.65839, 1 ], [ 0.423689, - 6.46E-4, + 0.000646, 0.658956, 1 ], @@ -132928,9 +135179,9 @@ "peptide_bond", "peptide_bond", "peptide_bond", - "hbond / peptide_bond", - "hbond / peptide_bond", - "hbond / peptide_bond", + "peptide_bond / hbond", + "peptide_bond / hbond", + "peptide_bond / hbond", "peptide_bond", "peptide_bond", "peptide_bond", @@ -133646,10 +135897,10 @@ 6.87125, null, 5.35325, - 8.60511111111111, + 7.5451250000000005, null, 5.35325, - 7.5451250000000005, + 8.60511111111111, null, 6.87125, 6.381363636363636, @@ -134197,10 +136448,10 @@ 44.50725, null, 42.97475, - 36.29877777777777, + 39.27775, null, 42.97475, - 39.27775, + 36.29877777777777, null, 44.50725, 45.36172727272727, @@ -134748,10 +136999,10 @@ 10.6975, null, 13.661833333333334, - 12.690222222222223, + 9.193375, null, 13.661833333333334, - 9.193375, + 12.690222222222223, null, 10.6975, 6.130272727272726, @@ -136019,19 +138270,19 @@ }, { "cell_type": "code", - "execution_count": 56, + "execution_count": 25, "metadata": {}, "outputs": [ { "name": "stdout", "output_type": "stream", "text": [ - "A:PRO:110 A:HIS:111 {'kind': {'peptide_bond'}, 'hist_status': 1}\n", - "A:HIS:111 A:ASP:112 {'kind': {'peptide_bond'}, 'hist_status': 1}\n", - "A:LYS:136 A:HIS:137 {'kind': {'peptide_bond'}, 'hist_status': 1}\n", - "A:HIS:137 A:PHE:138 {'kind': {'peptide_bond'}, 'hist_status': 1}\n", - "A:ALA:162 A:HIS:163 {'kind': {'peptide_bond'}, 'hist_status': 1}\n", - "A:HIS:163 A:LYS:164 {'kind': {'peptide_bond'}, 'hist_status': 1}\n", + "A:PRO:110 A:HIS:111 {'kind': {'peptide_bond'}, 'distance': 5.847328131684746, 'hist_status': 1}\n", + "A:HIS:111 A:ASP:112 {'kind': {'peptide_bond'}, 'distance': 4.3630030132639135, 'hist_status': 1}\n", + "A:LYS:136 A:HIS:137 {'kind': {'peptide_bond'}, 'distance': 5.948533615517212, 'hist_status': 1}\n", + "A:HIS:137 A:PHE:138 {'kind': {'peptide_bond'}, 'distance': 6.216579703077151, 'hist_status': 1}\n", + "A:ALA:162 A:HIS:163 {'kind': {'peptide_bond'}, 'distance': 4.108152275658732, 'hist_status': 1}\n", + "A:HIS:163 A:LYS:164 {'kind': {'peptide_bond'}, 'distance': 6.763154979266725, 'hist_status': 1}\n", "Graph-level hist feature: 1644\n" ] } @@ -136082,11 +138333,8 @@ } ], "metadata": { - "interpreter": { - "hash": "99ab8f253da66cd1d46a0a8aaa18c9c428feafa5ad7e5718c020d9b843cbce54" - }, "kernelspec": { - "display_name": "graphein-dev", + "display_name": "Python 3.8.12 ('graphein-wip')", "language": "python", "name": "python3" }, @@ -136100,9 +138348,14 @@ "name": "python", "nbconvert_exporter": "python", "pygments_lexer": "ipython3", - "version": "3.8.12" + "version": "3.8.13" + }, + "vscode": { + "interpreter": { + "hash": "2084dd4fc0c9f9186ef9bb5d9f5c6652432726a285d6ac2dcf2b1a616ab39cbb" + } } }, "nbformat": 4, "nbformat_minor": 4 -} \ No newline at end of file +} diff --git a/notebooks/rna_graph_tutorial.ipynb b/notebooks/rna_graph_tutorial.ipynb index 8b3c31d9..05ce837f 100644 --- a/notebooks/rna_graph_tutorial.ipynb +++ b/notebooks/rna_graph_tutorial.ipynb @@ -9,11 +9,7 @@ "\n", "[API Reference](https://graphein.ai/modules/graphein.rna.html#)\n", "\n", - "In this notebook we construct graphs of RNA secondary structures.\n", - "\n", - "The inputs we require are a sequence (optional) and a [dotbracket](https://www.tbi.univie.ac.at/RNA/ViennaRNA/doc/html/rna_structure_notations.html) specification of the secondary structure.\n", - "\n", - "The workflow we follow is similar to the other data modalities. The desired edge constructions are passed as a list of functions to the construction function.\n", + "In this notebook we construct graphs of RNA structures. The workflow we follow is similar to the other data modalities. The desired edge constructions are passed as a list of functions to the construction function.\n", "\n", "[![Open In Colab](https://colab.research.google.com/assets/colab-badge.svg)](https://colab.research.google.com/github/a-r-j/graphein/blob/master/notebooks/rna_graph_tutorial.ipynb)\n", "\n", @@ -22,7 +18,7 @@ }, { "cell_type": "code", - "execution_count": 6, + "execution_count": 1, "id": "afca1888", "metadata": {}, "outputs": [], @@ -31,26 +27,28 @@ "# !pip install graphein" ] }, + { + "cell_type": "markdown", + "id": "68809515", + "metadata": {}, + "source": [ + "## Constructing 2D RNA Graphs\n", + "The inputs we require are a sequence (optional) and a [dotbracket](https://www.tbi.univie.ac.at/RNA/ViennaRNA/doc/html/rna_structure_notations.html) specification of the secondary structure." + ] + }, { "cell_type": "code", - "execution_count": 7, + "execution_count": 5, "id": "3334d136", "metadata": {}, "outputs": [], "source": [ - "import logging\n", - "logging.getLogger(\"matplotlib\").setLevel(logging.WARNING)\n", - "logging.getLogger(\"graphein\").setLevel(logging.WARNING)\n", + "from rich import inspect\n", + "import matplotlib.pyplot as plt\n", "\n", "from typing import List, Callable\n", "import networkx as nx\n", - "from graphein.rna.graphs import construct_rna_graph\n", - "from graphein.rna.edges import (\n", - " add_all_dotbracket_edges,\n", - " add_pseudoknots,\n", - " add_phosphodiester_bonds,\n", - " add_base_pairing_interactions\n", - ")" + "import graphein.rna as gr" ] }, { @@ -60,12 +58,62 @@ "source": [ "### Construction with a Dotbracket\n", "\n", - "Graph construction is handled by the [`construct_rna_graph()`](https://graphein.ai/modules/graphein.rna.html#graphein.rna.graphs.construct_rna_graph) function.\n" + "Graph construction is handled by the [`construct_graph()`](https://graphein.ai/modules/graphein.rna.html#graphein.rna.graphs.construct_graph) function.\n", + "\n", + "Dotbrackets are strings composed of, funnily enough, dots : `\".\"` and brackets: `\"(\"` / `\")\"` (in their simplest form) that denote RNA secondary structures. Each character in the string represents a base, open brackets indicate a base is paired to a base ahead of it in the sequence and, conversely, closed brackets denote that a base is paired a preceding position.\n" + ] + }, + { + "cell_type": "code", + "execution_count": 6, + "id": "f4b290ce", + "metadata": {}, + "outputs": [ + { + "data": { + "text/html": [ + "
╭────────────────────── <function construct_graph at 0x7f7789a26700> ───────────────────────╮\n",
+       " def construct_graph(dotbracket: Union[str, NoneType] = None, sequence: Union[str,         \n",
+       " NoneType] = None, bprna_id: Union[str, NoneType] = None, use_nussinov: bool = False,      \n",
+       " config: Union[graphein.rna.config.RNAGraphConfig, NoneType] = None, pdb_path: Union[str,  \n",
+       " NoneType] = None, pdb_code: Union[str, NoneType] = None, chain_selection: str = 'all',    \n",
+       " rna_df_processing_funcs: Union[List[Callable], NoneType] = None, edge_construction_funcs: \n",
+       " Union[List[Callable], NoneType] = None, edge_annotation_funcs: Union[List[Callable],      \n",
+       " NoneType] = None, node_annotation_funcs: Union[List[Callable], NoneType] = None,          \n",
+       " graph_annotation_funcs: Union[List[Callable], NoneType] = None) ->                        \n",
+       " networkx.classes.graph.Graph:                                                             \n",
+       "                                                                                           \n",
+       " 35 attribute(s) not shown. Run inspect(inspect) for options.                              \n",
+       "╰───────────────────────────────────────────────────────────────────────────────────────────╯\n",
+       "
\n" + ], + "text/plain": [ + "\u001b[34m╭─\u001b[0m\u001b[34m───────────────────── \u001b[0m\u001b[1;34m<\u001b[0m\u001b[1;95mfunction\u001b[0m\u001b[39m construct_graph at \u001b[0m\u001b[1;36m0x7f7789a26700\u001b[0m\u001b[1;34m>\u001b[0m\u001b[34m ──────────────────────\u001b[0m\u001b[34m─╮\u001b[0m\n", + "\u001b[34m│\u001b[0m \u001b[3;96mdef \u001b[0m\u001b[1;31mconstruct_graph\u001b[0m\u001b[1m(\u001b[0mdotbracket: Union\u001b[1m[\u001b[0mstr, NoneType\u001b[1m]\u001b[0m = \u001b[3;35mNone\u001b[0m, sequence: Union\u001b[1m[\u001b[0mstr, \u001b[34m│\u001b[0m\n", + "\u001b[34m│\u001b[0m NoneType\u001b[1m]\u001b[0m = \u001b[3;35mNone\u001b[0m, bprna_id: Union\u001b[1m[\u001b[0mstr, NoneType\u001b[1m]\u001b[0m = \u001b[3;35mNone\u001b[0m, use_nussinov: bool = \u001b[3;91mFalse\u001b[0m, \u001b[34m│\u001b[0m\n", + "\u001b[34m│\u001b[0m config: Union\u001b[1m[\u001b[0mgraphein.rna.config.RNAGraphConfig, NoneType\u001b[1m]\u001b[0m = \u001b[3;35mNone\u001b[0m, pdb_path: Union\u001b[1m[\u001b[0mstr, \u001b[34m│\u001b[0m\n", + "\u001b[34m│\u001b[0m NoneType\u001b[1m]\u001b[0m = \u001b[3;35mNone\u001b[0m, pdb_code: Union\u001b[1m[\u001b[0mstr, NoneType\u001b[1m]\u001b[0m = \u001b[3;35mNone\u001b[0m, chain_selection: str = \u001b[32m'all'\u001b[0m, \u001b[34m│\u001b[0m\n", + "\u001b[34m│\u001b[0m rna_df_processing_funcs: Union\u001b[1m[\u001b[0mList\u001b[1m[\u001b[0mCallable\u001b[1m]\u001b[0m, NoneType\u001b[1m]\u001b[0m = \u001b[3;35mNone\u001b[0m, edge_construction_funcs: \u001b[34m│\u001b[0m\n", + "\u001b[34m│\u001b[0m Union\u001b[1m[\u001b[0mList\u001b[1m[\u001b[0mCallable\u001b[1m]\u001b[0m, NoneType\u001b[1m]\u001b[0m = \u001b[3;35mNone\u001b[0m, edge_annotation_funcs: Union\u001b[1m[\u001b[0mList\u001b[1m[\u001b[0mCallable\u001b[1m]\u001b[0m, \u001b[34m│\u001b[0m\n", + "\u001b[34m│\u001b[0m NoneType\u001b[1m]\u001b[0m = \u001b[3;35mNone\u001b[0m, node_annotation_funcs: Union\u001b[1m[\u001b[0mList\u001b[1m[\u001b[0mCallable\u001b[1m]\u001b[0m, NoneType\u001b[1m]\u001b[0m = \u001b[3;35mNone\u001b[0m, \u001b[34m│\u001b[0m\n", + "\u001b[34m│\u001b[0m graph_annotation_funcs: Union\u001b[1m[\u001b[0mList\u001b[1m[\u001b[0mCallable\u001b[1m]\u001b[0m, NoneType\u001b[1m]\u001b[0m = \u001b[3;35mNone\u001b[0m\u001b[1m)\u001b[0m -> \u001b[34m│\u001b[0m\n", + "\u001b[34m│\u001b[0m networkx.classes.graph.Graph: \u001b[34m│\u001b[0m\n", + "\u001b[34m│\u001b[0m \u001b[34m│\u001b[0m\n", + "\u001b[34m│\u001b[0m \u001b[1;36m35\u001b[0m\u001b[3m attribute(s) not shown.\u001b[0m Run \u001b[1;35minspect\u001b[0m\u001b[1m(\u001b[0minspect\u001b[1m)\u001b[0m for options. \u001b[34m│\u001b[0m\n", + "\u001b[34m╰───────────────────────────────────────────────────────────────────────────────────────────╯\u001b[0m\n" + ] + }, + "metadata": {}, + "output_type": "display_data" + } + ], + "source": [ + "inspect(gr.construct_graph)" ] }, { "cell_type": "code", - "execution_count": 8, + "execution_count": 7, "id": "a48d46c8-a8de-4641-b702-f6f3f4cc31f8", "metadata": {}, "outputs": [ @@ -73,12 +121,12 @@ "name": "stderr", "output_type": "stream", "text": [ - "WARNING:graphein.rna.visualisation:No sequence data found in graph. Skipping base type labelling.\n" + "No sequence data found in graph. Skipping base type labelling.\n" ] }, { "data": { - "image/png": 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", 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", "text/plain": [ "
" ] @@ -88,22 +136,21 @@ } ], "source": [ - "from graphein.rna.visualisation import plot_rna_graph\n", "edge_funcs_1: List[Callable] = [\n", - " add_base_pairing_interactions,\n", - " add_phosphodiester_bonds,\n", - " add_pseudoknots,\n", + " gr.add_base_pairing_interactions,\n", + " gr.add_phosphodiester_bonds,\n", + " gr.add_pseudoknots,\n", "]\n", - "edge_funcs_2: List[Callable] = [add_all_dotbracket_edges]\n", + "edge_funcs_2: List[Callable] = [gr.add_all_dotbracket_edges]\n", "\n", - "g = construct_rna_graph(\n", + "g = gr.construct_graph(\n", " \"......((((((......[[[))))))......]]]....\",\n", " sequence=None,\n", " edge_construction_funcs=edge_funcs_1,\n", ")\n", "nx.draw(g)\n", "\n", - "plot_rna_graph(g, layout=nx.layout.spring_layout)" + "gr.plot_rna_graph(g, layout=nx.layout.spring_layout)" ] }, { @@ -116,15 +163,15 @@ }, { "cell_type": "code", - "execution_count": 9, + "execution_count": 11, "id": "94e20b13", "metadata": {}, "outputs": [ { "data": { - "image/png": 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", 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", 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" ] }, "metadata": {}, @@ -132,23 +179,105 @@ } ], "source": [ - "g = construct_rna_graph(\n", + "\n", + "g = gr.construct_graph(\n", " sequence=\"CGUCUUAAACUCAUCACCGUGUGGAGCUGCGACCCUUCCCUAGAUUCGAAGACGAG\",\n", " dotbracket=\"((((((...(((..(((...))))))...(((..((.....))..)))))))))..\",\n", " edge_construction_funcs=edge_funcs_1,\n", ")\n", - "plot_rna_graph(g, layout=nx.layout.spring_layout)" + "plt.subplot(121)\n", + "gr.plot_rna_graph(g, layout=nx.layout.spring_layout)\n", + "plt.subplot(122)\n", + "gr.plot_rna_graph(g, layout=nx.layout.circular_layout) # We can use any nx layout we wish" + ] + }, + { + "cell_type": "markdown", + "id": "fbe90946", + "metadata": {}, + "source": [ + "### Using the Nussinov Algorithm to predict Secondary Structure with only a Sequence\n", + "\n", + "The Nussinov Algorithm is a DP-based approach to predict the secondary structure of RNA molecules. This is useful in the scenario where you have an RNA sequence but no known/determined secondary structure.\n", + "\n", + "#### Description \n", + "*(From the [wiki article](https://en.wikipedia.org/wiki/Nussinov_algorithm))*\n", + "\n", + "##### Scoring\n", + "We score a solution by counting the total number of paired bases. Thus, attempting to maximize the score maximizes the total number of bonds between bases.\n", + "\n", + "##### Motivation\n", + "Consider an RNA sequence $S$ whose elements are taken from the set $\\{A,U,C,G\\}$. Let us imagine we have an optimal solution to the subproblem of folding $S_{i}$ to $S_{j-1}$, and an optimal solution for folding $S_{u}$ to $S_{v}$ $ i\\leq u\\leq v\\leq j-1$. Now, to align $S_{i}$ to $S_{j}$, we have two options:\n", + "\n", + "1. Leave $S_{j}$ unpaired, and keep the structure of $S_{i}$ to $S_{j-1}$. The score for this alignment will be equal to the score of the alignment of $S_{i}$ to $S_{j-1}$, as no new base pairs were created.\n", + "2. Pair $S_{j}$ with $S_{k}$, where $i\\leq k╭───────────────────────────────── <class 'dict'> ──────────────────────────────────╮\n", + " dict() -> new empty dictionary \n", + " dict(mapping) -> new dictionary initialized from a mapping object's \n", + " (key, value) pairs \n", + " dict(iterable) -> new dictionary initialized as if via: \n", + " d = {} \n", + " for k, v in iterable: \n", + " d[k] = v \n", + " dict(**kwargs) -> new dictionary initialized with the name=value pairs \n", + " in the keyword argument list. For example: dict(one=1, two=2) \n", + " \n", + " ╭───────────────────────────────────────────────────────────────────────────────╮ \n", + " { \n", + " 'dotbracket': '((((((((..((.(.(..(.(.((..........)..)))))))))..))))))..', \n", + " 'sequence': 'CGUCUUAAACUCAUCACCGUGUGGAGCUGCGACCCUUCCCUAGAUUCGAAGACGAG' \n", + " } \n", + " ╰───────────────────────────────────────────────────────────────────────────────╯ \n", + " \n", + " 30 attribute(s) not shown. Run inspect(inspect) for options. \n", + "╰───────────────────────────────────────────────────────────────────────────────────╯\n", + "\n" + ], + "text/plain": [ + "\u001b[34m╭─\u001b[0m\u001b[34m──────────────────────────────── \u001b[0m\u001b[1;34m<\u001b[0m\u001b[1;95mclass\u001b[0m\u001b[39m \u001b[0m\u001b[32m'dict'\u001b[0m\u001b[1;34m>\u001b[0m\u001b[34m ─────────────────────────────────\u001b[0m\u001b[34m─╮\u001b[0m\n", + "\u001b[34m│\u001b[0m \u001b[1;35mdict\u001b[0m\u001b[1;36m(\u001b[0m\u001b[1;36m)\u001b[0m\u001b[36m -> new empty dictionary\u001b[0m \u001b[34m│\u001b[0m\n", + "\u001b[34m│\u001b[0m \u001b[1;35mdict\u001b[0m\u001b[1;36m(\u001b[0m\u001b[36mmapping\u001b[0m\u001b[1;36m)\u001b[0m\u001b[36m -> new dictionary initialized from a mapping object's\u001b[0m \u001b[34m│\u001b[0m\n", + "\u001b[34m│\u001b[0m \u001b[36m \u001b[0m\u001b[1;36m(\u001b[0m\u001b[36mkey, value\u001b[0m\u001b[1;36m)\u001b[0m\u001b[36m pairs\u001b[0m \u001b[34m│\u001b[0m\n", + "\u001b[34m│\u001b[0m \u001b[1;35mdict\u001b[0m\u001b[1;36m(\u001b[0m\u001b[36miterable\u001b[0m\u001b[1;36m)\u001b[0m\u001b[36m -> new dictionary initialized as if via:\u001b[0m \u001b[34m│\u001b[0m\n", + "\u001b[34m│\u001b[0m \u001b[36m d = \u001b[0m\u001b[1;36m{\u001b[0m\u001b[1;36m}\u001b[0m \u001b[34m│\u001b[0m\n", + "\u001b[34m│\u001b[0m \u001b[36m for k, v in iterable:\u001b[0m \u001b[34m│\u001b[0m\n", + "\u001b[34m│\u001b[0m \u001b[36m d\u001b[0m\u001b[1;36m[\u001b[0m\u001b[36mk\u001b[0m\u001b[1;36m]\u001b[0m\u001b[36m = v\u001b[0m \u001b[34m│\u001b[0m\n", + "\u001b[34m│\u001b[0m \u001b[1;35mdict\u001b[0m\u001b[1;36m(\u001b[0m\u001b[36m**kwargs\u001b[0m\u001b[1;36m)\u001b[0m\u001b[36m -> new dictionary initialized with the \u001b[0m\u001b[33mname\u001b[0m\u001b[36m=\u001b[0m\u001b[35mvalue\u001b[0m\u001b[36m pairs\u001b[0m \u001b[34m│\u001b[0m\n", + "\u001b[34m│\u001b[0m \u001b[36m in the keyword argument list. For example: \u001b[0m\u001b[1;35mdict\u001b[0m\u001b[1;36m(\u001b[0m\u001b[33mone\u001b[0m\u001b[36m=\u001b[0m\u001b[1;36m1\u001b[0m\u001b[36m, \u001b[0m\u001b[33mtwo\u001b[0m\u001b[36m=\u001b[0m\u001b[1;36m2\u001b[0m\u001b[1;36m)\u001b[0m \u001b[34m│\u001b[0m\n", + "\u001b[34m│\u001b[0m \u001b[34m│\u001b[0m\n", + "\u001b[34m│\u001b[0m \u001b[32m╭───────────────────────────────────────────────────────────────────────────────╮\u001b[0m \u001b[34m│\u001b[0m\n", + "\u001b[34m│\u001b[0m \u001b[32m│\u001b[0m \u001b[1m{\u001b[0m \u001b[32m│\u001b[0m \u001b[34m│\u001b[0m\n", + "\u001b[34m│\u001b[0m \u001b[32m│\u001b[0m \u001b[2;32m│ \u001b[0m\u001b[32m'dotbracket'\u001b[0m: 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\u001b[0m\u001b[32m'sequence'\u001b[0m: \u001b[32m'CGUCUUAAACUCAUCACCGUGUGGAGCUGCGACCCUUCCCUAGAUUCGAAGACGAG'\u001b[0m \u001b[32m│\u001b[0m \u001b[34m│\u001b[0m\n", + "\u001b[34m│\u001b[0m \u001b[32m│\u001b[0m \u001b[1m}\u001b[0m \u001b[32m│\u001b[0m \u001b[34m│\u001b[0m\n", + "\u001b[34m│\u001b[0m \u001b[32m╰───────────────────────────────────────────────────────────────────────────────╯\u001b[0m \u001b[34m│\u001b[0m\n", + "\u001b[34m│\u001b[0m \u001b[34m│\u001b[0m\n", + "\u001b[34m│\u001b[0m \u001b[1;36m30\u001b[0m\u001b[3m attribute(s) not shown.\u001b[0m Run \u001b[1;35minspect\u001b[0m\u001b[1m(\u001b[0minspect\u001b[1m)\u001b[0m for options. \u001b[34m│\u001b[0m\n", + "\u001b[34m╰───────────────────────────────────────────────────────────────────────────────────╯\u001b[0m\n" + ] + }, + "metadata": {}, + "output_type": "display_data" + }, + { + "data": { + "image/png": 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", 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" ] @@ -158,18 +287,610354 @@ } ], "source": [ - "g = construct_rna_graph(\n", + "# NBVAL_SKIP\n", + "g = gr.construct_graph(\n", " sequence=\"CGUCUUAAACUCAUCACCGUGUGGAGCUGCGACCCUUCCCUAGAUUCGAAGACGAG\",\n", - " dotbracket=\"((((((...(((..(((...))))))...(((..((.....))..)))))))))..\",\n", + " dotbracket=None,\n", " edge_construction_funcs=edge_funcs_1,\n", + " use_nussinov=True\n", ")\n", - "plot_rna_graph(g, layout=nx.layout.circular_layout)" + "gr.plot_rna_graph(g, layout=nx.layout.spring_layout)\n", + "inspect(g.graph)" + ] + }, + { + "cell_type": "markdown", + "id": "7c8df698", + "metadata": {}, + "source": [ + "## Constructing 3D Graphs of RNA Structures\n", + "\n", + "Similar to [Protein Structures](https://graphein.ai/notebooks/atom_graph_tutorial.html), we can construct 3D graphs of RNA structures in the PDB using [`graphein.rna.construct_graph()`](https://graphein.ai/modules/graphein.rna.html#graphein.rna.graphs.construct_graph).\n", + "\n", + "### Config" + ] + }, + { + "cell_type": "code", + "execution_count": 26, + "id": "47314106", + "metadata": {}, + "outputs": [ + { + "data": { + "text/html": [ + "
╭────────────────────── <class 'graphein.rna.config.RNAGraphConfig'> ───────────────────────╮\n",
+       " Config Object for RNA Structure Graph Construction.                                       \n",
+       "                                                                                           \n",
+       " ╭───────────────────────────────────────────────────────────────────────────────────────╮ \n",
+       "  RNAGraphConfig(granularity='rna_atom', verbose=False,                                  \n",
+       "  edge_construction_functions=[<function add_atomic_edges at 0x7f78fa9da5e0>],           \n",
+       "  rna_df_processing_functions=None, node_metadata_functions=None,                        \n",
+       "  edge_metadata_functions=None, graph_metadata_functions=None)                           \n",
+       " ╰───────────────────────────────────────────────────────────────────────────────────────╯ \n",
+       "                                                                                           \n",
+       " edge_construction_functions = [<function add_atomic_edges at 0x7f78fa9da5e0>]             \n",
+       "     edge_metadata_functions = None                                                        \n",
+       "                 granularity = 'rna_atom'                                                  \n",
+       "    graph_metadata_functions = None                                                        \n",
+       "     node_metadata_functions = None                                                        \n",
+       " rna_df_processing_functions = None                                                        \n",
+       "                     verbose = False                                                       \n",
+       "╰───────────────────────────────────────────────────────────────────────────────────────────╯\n",
+       "
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\u001b[33medge_construction_functions\u001b[0m=\u001b[1m[\u001b[0m\u001b[1m<\u001b[0m\u001b[1;95mfunction\u001b[0m\u001b[39m add_atomic_edges at \u001b[0m\u001b[1;36m0x7f78fa9da5e0\u001b[0m\u001b[1m>\u001b[0m\u001b[1m]\u001b[0m, \u001b[32m│\u001b[0m \u001b[34m│\u001b[0m\n", + "\u001b[34m│\u001b[0m \u001b[32m│\u001b[0m \u001b[33mrna_df_processing_functions\u001b[0m=\u001b[3;35mNone\u001b[0m, \u001b[33mnode_metadata_functions\u001b[0m=\u001b[3;35mNone\u001b[0m, \u001b[32m│\u001b[0m \u001b[34m│\u001b[0m\n", + "\u001b[34m│\u001b[0m \u001b[32m│\u001b[0m \u001b[33medge_metadata_functions\u001b[0m=\u001b[3;35mNone\u001b[0m, \u001b[33mgraph_metadata_functions\u001b[0m=\u001b[3;35mNone\u001b[0m\u001b[1m)\u001b[0m \u001b[32m│\u001b[0m \u001b[34m│\u001b[0m\n", + "\u001b[34m│\u001b[0m \u001b[32m╰───────────────────────────────────────────────────────────────────────────────────────╯\u001b[0m \u001b[34m│\u001b[0m\n", + "\u001b[34m│\u001b[0m \u001b[34m│\u001b[0m\n", + "\u001b[34m│\u001b[0m \u001b[3;33medge_construction_functions\u001b[0m = \u001b[1m[\u001b[0m\u001b[1m<\u001b[0m\u001b[1;95mfunction\u001b[0m\u001b[39m add_atomic_edges at \u001b[0m\u001b[1;36m0x7f78fa9da5e0\u001b[0m\u001b[1m>\u001b[0m\u001b[1m]\u001b[0m \u001b[34m│\u001b[0m\n", + "\u001b[34m│\u001b[0m \u001b[3;33medge_metadata_functions\u001b[0m = \u001b[3;35mNone\u001b[0m \u001b[34m│\u001b[0m\n", + "\u001b[34m│\u001b[0m \u001b[3;33mgranularity\u001b[0m = \u001b[32m'rna_atom'\u001b[0m \u001b[34m│\u001b[0m\n", + "\u001b[34m│\u001b[0m \u001b[3;33mgraph_metadata_functions\u001b[0m = \u001b[3;35mNone\u001b[0m \u001b[34m│\u001b[0m\n", + "\u001b[34m│\u001b[0m \u001b[3;33mnode_metadata_functions\u001b[0m = \u001b[3;35mNone\u001b[0m \u001b[34m│\u001b[0m\n", + "\u001b[34m│\u001b[0m \u001b[3;33mrna_df_processing_functions\u001b[0m = \u001b[3;35mNone\u001b[0m \u001b[34m│\u001b[0m\n", + "\u001b[34m│\u001b[0m \u001b[3;33mverbose\u001b[0m = \u001b[3;91mFalse\u001b[0m \u001b[34m│\u001b[0m\n", + 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config=config)\n", + "gr.plotly_rna_structure_graph(g, colour_nodes_by=\"residue_name\")" + ] + }, + { + "cell_type": "code", + "execution_count": 28, + "id": "ef5c6348", + "metadata": {}, + "outputs": [ + { + "data": { + "text/html": [ + "
╭───────────────────────────────────── <class 'dict'> ──────────────────────────────────────╮\n",
+       " dict() -> new empty dictionary                                                            \n",
+       " dict(mapping) -> new dictionary initialized from a mapping object's                       \n",
+       "     (key, value) pairs                                                                    \n",
+       " dict(iterable) -> new dictionary initialized as if via:                                   \n",
+       "     d = {}                                                                                \n",
+       "     for k, v in iterable:                                                                 \n",
+       "         d[k] = v                                                                          \n",
+       " dict(**kwargs) -> new dictionary initialized with the name=value pairs                    \n",
+       "     in the keyword argument list.  For example:  dict(one=1, two=2)                       \n",
+       "                                                                                           \n",
+       " ╭───────────────────────────────────────────────────────────────────────────────────────╮ \n",
+       "  {                                                                                      \n",
+       "  'name': '2jyf',                                                                    \n",
+       "  'pdb_id': '2jyf',                                                                  \n",
+       "  'chain_ids': ['A', 'B'],                                                           \n",
+       "  'pdb_df':      record_name  atom_number blank_1 atom_name alt_loc residue_name     \n",
+       "  blank_2  \\                                                                             \n",
+       "  0           ATOM            1               O5'                    G                   \n",
+       "  1           ATOM            2               C5'                    G                   \n",
+       "  2           ATOM            3               C4'                    G                   \n",
+       "  3           ATOM            4               O4'                    G                   \n",
+       "  4           ATOM            5               C3'                    G                   \n",
+       "  ...          ...          ...     ...       ...     ...          ...     ...           \n",
+       "  1831        ATOM         2750                N3                    U                   \n",
+       "  1832        ATOM         2751                C4                    U                   \n",
+       "  1833        ATOM         2752                O4                    U                   \n",
+       "  1834        ATOM         2753                C5                    U                   \n",
+       "  1835        ATOM         2754                C6                    U                   \n",
+       "                                                                                    \n",
+       "  chain_id  residue_number insertion  ... y_coord  z_coord  occupancy  \\            \n",
+       "  0           A               1            ... -37.668    9.239        1.0               \n",
+       "  1           A               1            ... -38.206    8.391        1.0               \n",
+       "  2           A               1            ... -38.940    7.196        1.0               \n",
+       "  3           A               1            ... -40.138    7.644        1.0               \n",
+       "  4           A               1            ... -38.116    6.432        1.0               \n",
+       "  ...       ...             ...       ...  ...     ...      ...        ...               \n",
+       "  1831        B              86            ...  35.469   18.786        1.0               \n",
+       "  1832        B              86            ...  34.331   19.486        1.0               \n",
+       "  1833        B              86            ...  33.400   19.625        1.0               \n",
+       "  1834        B              86            ...  34.366   20.002        1.0               \n",
+       "  1835        B              86            ...  35.442   19.793        1.0               \n",
+       "                                                                                   \n",
+       "  b_factor  blank_4  segment_id element_symbol charge line_idx  \\                  \n",
+       "  0          1.0                                   O    NaN      130                     \n",
+       "  1          1.0                                   C    NaN      131                     \n",
+       "  2          1.0                                   C    NaN      132                     \n",
+       "  3          1.0                                   O    NaN      133                     \n",
+       "  4          1.0                                   C    NaN      134                     \n",
+       "  ...        ...      ...         ...            ...    ...      ...                     \n",
+       "  1831       1.0                                   N    NaN     2879                     \n",
+       "  1832       1.0                                   C    NaN     2880                     \n",
+       "  1833       1.0                                   O    NaN     2881                     \n",
+       "  1834       1.0                                   C    NaN     2882                     \n",
+       "  1835       1.0                                   C    NaN     2883                     \n",
+       "  │   │   │                                                                              \n",
+       "  │   │   │    node_id                                                                   \n",
+       "  0        A:G:1:1:O5'                                                                   \n",
+       "  1        A:G:1:2:C5'                                                                   \n",
+       "  2        A:G:1:3:C4'                                                                   \n",
+       "  3        A:G:1:4:O4'                                                                   \n",
+       "  4        A:G:1:5:C3'                                                                   \n",
+       "  ...              ...                                                                   \n",
+       "  1831  B:U:86:2750:N3                                                                   \n",
+       "  1832  B:U:86:2751:C4                                                                   \n",
+       "  1833  B:U:86:2752:O4                                                                   \n",
+       "  1834  B:U:86:2753:C5                                                                   \n",
+       "  1835  B:U:86:2754:C6                                                                   \n",
+       "                                                                                         \n",
+       "  [1836 rows x 22 columns],                                                              \n",
+       "  'raw_pdb_df':       record_name  atom_number blank_1 atom_name alt_loc             \n",
+       "  residue_name blank_2  \\                                                                \n",
+       "  0            ATOM            1               O5'                    G                  \n",
+       "  1            ATOM            2               C5'                    G                  \n",
+       "  2            ATOM            3               C4'                    G                  \n",
+       "  3            ATOM            4               O4'                    G                  \n",
+       "  4            ATOM            5               C3'                    G                  \n",
+       "  ...           ...          ...     ...       ...     ...          ...     ...          \n",
+       "  27635        ATOM         2761              HO2'                    U                  \n",
+       "  27636        ATOM         2762               H1'                    U                  \n",
+       "  27637        ATOM         2763                H3                    U                  \n",
+       "  27638        ATOM         2764                H5                    U                  \n",
+       "  27639        ATOM         2765                H6                    U                  \n",
+       "                                                                                   \n",
+       "  chain_id  residue_number insertion  ... y_coord  z_coord  occupancy  \\           \n",
+       "  0            A               1            ... -37.668    9.239        1.0              \n",
+       "  1            A               1            ... -38.206    8.391        1.0              \n",
+       "  2            A               1            ... -38.940    7.196        1.0              \n",
+       "  3            A               1            ... -40.138    7.644        1.0              \n",
+       "  4            A               1            ... -38.116    6.432        1.0              \n",
+       "  ...        ...             ...       ...  ...     ...      ...        ...              \n",
+       "  27635        B              86            ...  40.905   10.613        1.0              \n",
+       "  27636        B              86            ...  39.008   11.258        1.0              \n",
+       "  27637        B              86            ...  38.303   15.344        1.0              \n",
+       "  27638        B              86            ...  37.987   16.026        1.0              \n",
+       "  27639        B              86            ...  38.644   13.718        1.0              \n",
+       "                                                                                  \n",
+       "  b_factor  blank_4  segment_id element_symbol charge line_idx  \\                 \n",
+       "  0           1.0                                   O    NaN      130                    \n",
+       "  1           1.0                                   C    NaN      131                    \n",
+       "  2           1.0                                   C    NaN      132                    \n",
+       "  3           1.0                                   O    NaN      133                    \n",
+       "  4           1.0                                   C    NaN      134                    \n",
+       "  ...         ...      ...         ...            ...    ...      ...                    \n",
+       "  27635       1.0                                   H    NaN    27802                    \n",
+       "  27636       1.0                                   H    NaN    27803                    \n",
+       "  27637       1.0                                   H    NaN    27804                    \n",
+       "  27638       1.0                                   H    NaN    27805                    \n",
+       "  27639       1.0                                   H    NaN    27806                    \n",
+       "  │   │   │   │                                                                          \n",
+       "  │   │   │   │   node_id                                                                \n",
+       "  0           A:G:1:1:O5'                                                                \n",
+       "  1           A:G:1:2:C5'                                                                \n",
+       "  2           A:G:1:3:C4'                                                                \n",
+       "  3           A:G:1:4:O4'                                                                \n",
+       "  4           A:G:1:5:C3'                                                                \n",
+       "  ...                 ...                                                                \n",
+       "  27635  B:U:86:2761:HO2'                                                                \n",
+       "  27636   B:U:86:2762:H1'                                                                \n",
+       "  27637    B:U:86:2763:H3                                                                \n",
+       "  27638    B:U:86:2764:H5                                                                \n",
+       "  27639    B:U:86:2765:H6                                                                \n",
+       "                                                                                         \n",
+       "  [27640 rows x 22 columns],                                                             \n",
+       "  'rgroup_df':      record_name  atom_number blank_1 atom_name alt_loc residue_name  \n",
+       "  blank_2  \\                                                                             \n",
+       "  0           ATOM            1               O5'                    G                   \n",
+       "  1           ATOM            2               C5'                    G                   \n",
+       "  2           ATOM            3               C4'                    G                   \n",
+       "  3           ATOM            4               O4'                    G                   \n",
+       "  4           ATOM            5               C3'                    G                   \n",
+       "  ...          ...          ...     ...       ...     ...          ...     ...           \n",
+       "  2759        ATOM         2761              HO2'                    U                   \n",
+       "  2760        ATOM         2762               H1'                    U                   \n",
+       "  2761        ATOM         2763                H3                    U                   \n",
+       "  2762        ATOM         2764                H5                    U                   \n",
+       "  2763        ATOM         2765                H6                    U                   \n",
+       "                                                                                    \n",
+       "  chain_id  residue_number insertion  ... y_coord  z_coord  occupancy  \\            \n",
+       "  0           A               1            ... -37.668    9.239        1.0               \n",
+       "  1           A               1            ... -38.206    8.391        1.0               \n",
+       "  2           A               1            ... -38.940    7.196        1.0               \n",
+       "  3           A               1            ... -40.138    7.644        1.0               \n",
+       "  4           A               1            ... -38.116    6.432        1.0               \n",
+       "  ...       ...             ...       ...  ...     ...      ...        ...               \n",
+       "  2759        B              86            ...  39.771   18.792        1.0               \n",
+       "  2760        B              86            ...  38.212   17.955        1.0               \n",
+       "  2761        B              86            ...  35.491   18.406        1.0               \n",
+       "  2762        B              86            ...  33.518   20.570        1.0               \n",
+       "  2763        B              86            ...  35.443   20.194        1.0               \n",
+       "                                                                                   \n",
+       "  b_factor  blank_4  segment_id element_symbol charge line_idx  \\                  \n",
+       "  0          1.0                                   O    NaN      130                     \n",
+       "  1          1.0                                   C    NaN      131                     \n",
+       "  2          1.0                                   C    NaN      132                     \n",
+       "  3          1.0                                   O    NaN      133                     \n",
+       "  4          1.0                                   C    NaN      134                     \n",
+       "  ...        ...      ...         ...            ...    ...      ...                     \n",
+       "  2759       1.0                                   H    NaN     2890                     \n",
+       "  2760       1.0                                   H    NaN     2891                     \n",
+       "  2761       1.0                                   H    NaN     2892                     \n",
+       "  2762       1.0                                   H    NaN     2893                     \n",
+       "  2763       1.0                                   H    NaN     2894                     \n",
+       "  │   │   │                                                                              \n",
+       "  │   │   │      node_id                                                                 \n",
+       "  0          A:G:1:1:O5'                                                                 \n",
+       "  1          A:G:1:2:C5'                                                                 \n",
+       "  2          A:G:1:3:C4'                                                                 \n",
+       "  3          A:G:1:4:O4'                                                                 \n",
+       "  4          A:G:1:5:C3'                                                                 \n",
+       "  ...                ...                                                                 \n",
+       "  2759  B:U:86:2761:HO2'                                                                 \n",
+       "  2760   B:U:86:2762:H1'                                                                 \n",
+       "  2761    B:U:86:2763:H3                                                                 \n",
+       "  2762    B:U:86:2764:H5                                                                 \n",
+       "  2763    B:U:86:2765:H6                                                                 \n",
+       "                                                                                         \n",
+       "  [2764 rows x 22 columns],                                                              \n",
+       "  'coords': array([[  6.291, -37.668,   9.239],                                      \n",
+       "  [  7.307, -38.206,   8.391],                                                    \n",
+       "  [  6.703, -38.94 ,   7.196],                                                    \n",
+       "  ...,                                                                            \n",
+       "  [  2.641,  33.4  ,  19.625],                                                    \n",
+       "  [  4.782,  34.366,  20.002],                                                    \n",
+       "  [  5.579,  35.442,  19.793]]),                                                  \n",
+       "  'node_type': 'rna_atom',                                                           \n",
+       "  'sequence_A': 'GGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGG'+858,  \n",
+       "  'sequence_B': 'GGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGG'+858,  \n",
+       "  ... +2                                                                             \n",
+       "  }                                                                                      \n",
+       " ╰───────────────────────────────────────────────────────────────────────────────────────╯ \n",
+       "                                                                                           \n",
+       " 30 attribute(s) not shown. Run inspect(inspect) for options.                              \n",
+       "╰───────────────────────────────────────────────────────────────────────────────────────────╯\n",
+       "
\n" + ], + "text/plain": [ + "\u001b[34m╭─\u001b[0m\u001b[34m──────────────────────────────────── \u001b[0m\u001b[1;34m<\u001b[0m\u001b[1;95mclass\u001b[0m\u001b[39m \u001b[0m\u001b[32m'dict'\u001b[0m\u001b[1;34m>\u001b[0m\u001b[34m ─────────────────────────────────────\u001b[0m\u001b[34m─╮\u001b[0m\n", + "\u001b[34m│\u001b[0m \u001b[1;35mdict\u001b[0m\u001b[1;36m(\u001b[0m\u001b[1;36m)\u001b[0m\u001b[36m -> new empty dictionary\u001b[0m \u001b[34m│\u001b[0m\n", + "\u001b[34m│\u001b[0m \u001b[1;35mdict\u001b[0m\u001b[1;36m(\u001b[0m\u001b[36mmapping\u001b[0m\u001b[1;36m)\u001b[0m\u001b[36m -> new dictionary initialized from a mapping object's\u001b[0m \u001b[34m│\u001b[0m\n", + "\u001b[34m│\u001b[0m \u001b[36m \u001b[0m\u001b[1;36m(\u001b[0m\u001b[36mkey, value\u001b[0m\u001b[1;36m)\u001b[0m\u001b[36m pairs\u001b[0m \u001b[34m│\u001b[0m\n", + "\u001b[34m│\u001b[0m \u001b[1;35mdict\u001b[0m\u001b[1;36m(\u001b[0m\u001b[36miterable\u001b[0m\u001b[1;36m)\u001b[0m\u001b[36m -> new dictionary initialized as if via:\u001b[0m \u001b[34m│\u001b[0m\n", + "\u001b[34m│\u001b[0m \u001b[36m d = \u001b[0m\u001b[1;36m{\u001b[0m\u001b[1;36m}\u001b[0m \u001b[34m│\u001b[0m\n", + "\u001b[34m│\u001b[0m \u001b[36m for k, v in iterable:\u001b[0m \u001b[34m│\u001b[0m\n", + "\u001b[34m│\u001b[0m \u001b[36m d\u001b[0m\u001b[1;36m[\u001b[0m\u001b[36mk\u001b[0m\u001b[1;36m]\u001b[0m\u001b[36m = v\u001b[0m \u001b[34m│\u001b[0m\n", + "\u001b[34m│\u001b[0m \u001b[1;35mdict\u001b[0m\u001b[1;36m(\u001b[0m\u001b[36m**kwargs\u001b[0m\u001b[1;36m)\u001b[0m\u001b[36m -> new dictionary initialized with the \u001b[0m\u001b[33mname\u001b[0m\u001b[36m=\u001b[0m\u001b[35mvalue\u001b[0m\u001b[36m pairs\u001b[0m \u001b[34m│\u001b[0m\n", + "\u001b[34m│\u001b[0m \u001b[36m in the keyword argument list. For example: \u001b[0m\u001b[1;35mdict\u001b[0m\u001b[1;36m(\u001b[0m\u001b[33mone\u001b[0m\u001b[36m=\u001b[0m\u001b[1;36m1\u001b[0m\u001b[36m, \u001b[0m\u001b[33mtwo\u001b[0m\u001b[36m=\u001b[0m\u001b[1;36m2\u001b[0m\u001b[1;36m)\u001b[0m \u001b[34m│\u001b[0m\n", + "\u001b[34m│\u001b[0m \u001b[34m│\u001b[0m\n", + "\u001b[34m│\u001b[0m \u001b[32m╭───────────────────────────────────────────────────────────────────────────────────────╮\u001b[0m \u001b[34m│\u001b[0m\n", + "\u001b[34m│\u001b[0m \u001b[32m│\u001b[0m \u001b[1m{\u001b[0m \u001b[32m│\u001b[0m \u001b[34m│\u001b[0m\n", + "\u001b[34m│\u001b[0m \u001b[32m│\u001b[0m \u001b[2;32m│ \u001b[0m\u001b[32m'name'\u001b[0m: \u001b[32m'2jyf'\u001b[0m, \u001b[32m│\u001b[0m \u001b[34m│\u001b[0m\n", + "\u001b[34m│\u001b[0m \u001b[32m│\u001b[0m \u001b[2;32m│ \u001b[0m\u001b[32m'pdb_id'\u001b[0m: \u001b[32m'2jyf'\u001b[0m, \u001b[32m│\u001b[0m \u001b[34m│\u001b[0m\n", + "\u001b[34m│\u001b[0m \u001b[32m│\u001b[0m \u001b[2;32m│ \u001b[0m\u001b[32m'chain_ids'\u001b[0m: \u001b[1m[\u001b[0m\u001b[32m'A'\u001b[0m, \u001b[32m'B'\u001b[0m\u001b[1m]\u001b[0m, \u001b[32m│\u001b[0m \u001b[34m│\u001b[0m\n", + "\u001b[34m│\u001b[0m \u001b[32m│\u001b[0m \u001b[2;32m│ \u001b[0m\u001b[32m'pdb_df'\u001b[0m: record_name atom_number blank_1 atom_name alt_loc residue_name \u001b[32m│\u001b[0m \u001b[34m│\u001b[0m\n", + "\u001b[34m│\u001b[0m \u001b[32m│\u001b[0m blank_2 \\ \u001b[32m│\u001b[0m \u001b[34m│\u001b[0m\n", + "\u001b[34m│\u001b[0m \u001b[32m│\u001b[0m \u001b[1;36m0\u001b[0m ATOM \u001b[1;36m1\u001b[0m O5' G \u001b[32m│\u001b[0m \u001b[34m│\u001b[0m\n", + "\u001b[34m│\u001b[0m \u001b[32m│\u001b[0m \u001b[1;36m1\u001b[0m ATOM \u001b[1;36m2\u001b[0m C5' G \u001b[32m│\u001b[0m \u001b[34m│\u001b[0m\n", + "\u001b[34m│\u001b[0m \u001b[32m│\u001b[0m \u001b[1;36m2\u001b[0m ATOM \u001b[1;36m3\u001b[0m C4' G \u001b[32m│\u001b[0m \u001b[34m│\u001b[0m\n", + "\u001b[34m│\u001b[0m \u001b[32m│\u001b[0m \u001b[1;36m3\u001b[0m ATOM \u001b[1;36m4\u001b[0m O4' G \u001b[32m│\u001b[0m \u001b[34m│\u001b[0m\n", + "\u001b[34m│\u001b[0m \u001b[32m│\u001b[0m \u001b[1;36m4\u001b[0m ATOM \u001b[1;36m5\u001b[0m C3' G \u001b[32m│\u001b[0m \u001b[34m│\u001b[0m\n", + "\u001b[34m│\u001b[0m \u001b[32m│\u001b[0m \u001b[33m...\u001b[0m \u001b[33m...\u001b[0m \u001b[33m...\u001b[0m \u001b[33m...\u001b[0m \u001b[33m...\u001b[0m \u001b[33m...\u001b[0m \u001b[33m...\u001b[0m \u001b[33m...\u001b[0m \u001b[32m│\u001b[0m \u001b[34m│\u001b[0m\n", + "\u001b[34m│\u001b[0m \u001b[32m│\u001b[0m \u001b[1;36m1831\u001b[0m ATOM \u001b[1;36m2750\u001b[0m N3 U \u001b[32m│\u001b[0m \u001b[34m│\u001b[0m\n", + "\u001b[34m│\u001b[0m \u001b[32m│\u001b[0m \u001b[1;36m1832\u001b[0m ATOM \u001b[1;36m2751\u001b[0m C4 U \u001b[32m│\u001b[0m \u001b[34m│\u001b[0m\n", + "\u001b[34m│\u001b[0m \u001b[32m│\u001b[0m \u001b[1;36m1833\u001b[0m ATOM \u001b[1;36m2752\u001b[0m O4 U \u001b[32m│\u001b[0m \u001b[34m│\u001b[0m\n", + "\u001b[34m│\u001b[0m \u001b[32m│\u001b[0m \u001b[1;36m1834\u001b[0m ATOM \u001b[1;36m2753\u001b[0m C5 U \u001b[32m│\u001b[0m \u001b[34m│\u001b[0m\n", + "\u001b[34m│\u001b[0m \u001b[32m│\u001b[0m \u001b[1;36m1835\u001b[0m ATOM \u001b[1;36m2754\u001b[0m C6 U \u001b[32m│\u001b[0m \u001b[34m│\u001b[0m\n", + "\u001b[34m│\u001b[0m \u001b[32m│\u001b[0m \u001b[2;32m│ \u001b[0m \u001b[32m│\u001b[0m \u001b[34m│\u001b[0m\n", + "\u001b[34m│\u001b[0m \u001b[32m│\u001b[0m \u001b[2;32m│ \u001b[0mchain_id residue_number insertion \u001b[33m...\u001b[0m y_coord z_coord occupancy \\ \u001b[32m│\u001b[0m \u001b[34m│\u001b[0m\n", + "\u001b[34m│\u001b[0m \u001b[32m│\u001b[0m \u001b[1;36m0\u001b[0m A \u001b[1;36m1\u001b[0m \u001b[33m...\u001b[0m \u001b[1;36m-37.668\u001b[0m \u001b[1;36m9.239\u001b[0m \u001b[1;36m1.0\u001b[0m \u001b[32m│\u001b[0m \u001b[34m│\u001b[0m\n", + "\u001b[34m│\u001b[0m \u001b[32m│\u001b[0m \u001b[1;36m1\u001b[0m A \u001b[1;36m1\u001b[0m \u001b[33m...\u001b[0m \u001b[1;36m-38.206\u001b[0m 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blank_1 atom_name alt_loc \u001b[32m│\u001b[0m \u001b[34m│\u001b[0m\n", + "\u001b[34m│\u001b[0m \u001b[32m│\u001b[0m residue_name blank_2 \\ \u001b[32m│\u001b[0m \u001b[34m│\u001b[0m\n", + "\u001b[34m│\u001b[0m \u001b[32m│\u001b[0m \u001b[1;36m0\u001b[0m ATOM \u001b[1;36m1\u001b[0m O5' G \u001b[32m│\u001b[0m \u001b[34m│\u001b[0m\n", + "\u001b[34m│\u001b[0m \u001b[32m│\u001b[0m \u001b[1;36m1\u001b[0m ATOM \u001b[1;36m2\u001b[0m C5' G \u001b[32m│\u001b[0m \u001b[34m│\u001b[0m\n", + "\u001b[34m│\u001b[0m \u001b[32m│\u001b[0m \u001b[1;36m2\u001b[0m ATOM \u001b[1;36m3\u001b[0m C4' G \u001b[32m│\u001b[0m \u001b[34m│\u001b[0m\n", + "\u001b[34m│\u001b[0m \u001b[32m│\u001b[0m \u001b[1;36m3\u001b[0m ATOM \u001b[1;36m4\u001b[0m O4' G \u001b[32m│\u001b[0m \u001b[34m│\u001b[0m\n", + "\u001b[34m│\u001b[0m \u001b[32m│\u001b[0m \u001b[1;36m4\u001b[0m ATOM \u001b[1;36m5\u001b[0m C3' G \u001b[32m│\u001b[0m \u001b[34m│\u001b[0m\n", + "\u001b[34m│\u001b[0m \u001b[32m│\u001b[0m \u001b[33m...\u001b[0m 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"\u001b[34m│\u001b[0m \u001b[32m│\u001b[0m \u001b[2;32m│ \u001b[0m \u001b[32m│\u001b[0m \u001b[34m│\u001b[0m\n", + "\u001b[34m│\u001b[0m \u001b[32m│\u001b[0m \u001b[2;32m│ \u001b[0mchain_id residue_number insertion \u001b[33m...\u001b[0m y_coord z_coord occupancy \\ \u001b[32m│\u001b[0m \u001b[34m│\u001b[0m\n", + "\u001b[34m│\u001b[0m \u001b[32m│\u001b[0m \u001b[1;36m0\u001b[0m A \u001b[1;36m1\u001b[0m \u001b[33m...\u001b[0m \u001b[1;36m-37.668\u001b[0m \u001b[1;36m9.239\u001b[0m \u001b[1;36m1.0\u001b[0m \u001b[32m│\u001b[0m \u001b[34m│\u001b[0m\n", + "\u001b[34m│\u001b[0m \u001b[32m│\u001b[0m \u001b[1;36m1\u001b[0m A \u001b[1;36m1\u001b[0m \u001b[33m...\u001b[0m \u001b[1;36m-38.206\u001b[0m \u001b[1;36m8.391\u001b[0m \u001b[1;36m1.0\u001b[0m \u001b[32m│\u001b[0m \u001b[34m│\u001b[0m\n", + "\u001b[34m│\u001b[0m \u001b[32m│\u001b[0m \u001b[1;36m2\u001b[0m A \u001b[1;36m1\u001b[0m \u001b[33m...\u001b[0m \u001b[1;36m-38.940\u001b[0m \u001b[1;36m7.196\u001b[0m \u001b[1;36m1.0\u001b[0m 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"\u001b[34m│\u001b[0m \u001b[32m│\u001b[0m \u001b[1;36m27638\u001b[0m \u001b[1;36m1.0\u001b[0m H NaN \u001b[1;36m27805\u001b[0m \u001b[32m│\u001b[0m \u001b[34m│\u001b[0m\n", + "\u001b[34m│\u001b[0m \u001b[32m│\u001b[0m \u001b[1;36m27639\u001b[0m \u001b[1;36m1.0\u001b[0m H NaN \u001b[1;36m27806\u001b[0m \u001b[32m│\u001b[0m \u001b[34m│\u001b[0m\n", + "\u001b[34m│\u001b[0m \u001b[32m│\u001b[0m \u001b[2;32m│ │ │ │ \u001b[0m \u001b[32m│\u001b[0m \u001b[34m│\u001b[0m\n", + "\u001b[34m│\u001b[0m \u001b[32m│\u001b[0m \u001b[2;32m│ │ │ │ \u001b[0mnode_id \u001b[32m│\u001b[0m \u001b[34m│\u001b[0m\n", + "\u001b[34m│\u001b[0m \u001b[32m│\u001b[0m \u001b[1;36m0\u001b[0m A:G:\u001b[1;92m1:1\u001b[0m:O5' \u001b[32m│\u001b[0m \u001b[34m│\u001b[0m\n", + "\u001b[34m│\u001b[0m \u001b[32m│\u001b[0m \u001b[1;36m1\u001b[0m A:G:\u001b[1;92m1:2:C5\u001b[0m' \u001b[32m│\u001b[0m \u001b[34m│\u001b[0m\n", + "\u001b[34m│\u001b[0m \u001b[32m│\u001b[0m \u001b[1;36m2\u001b[0m A:G:\u001b[1;92m1:3:C4\u001b[0m' 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╭────────────────────── <class 'tuple'> ───────────────────────╮\n",
+       " Built-in immutable sequence.                                 \n",
+       "                                                              \n",
+       " ╭──────────────────────────────────────────────────────────╮ \n",
+       "  (                                                         \n",
+       "  \"A:G:1:1:O5'\",                                        \n",
+       "  {                                                     \n",
+       "  │   │   'chain_id': 'A',                                  \n",
+       "  │   │   'residue_name': 'G',                              \n",
+       "  │   │   'residue_number': 1,                              \n",
+       "  │   │   'atom_type': \"O5'\",                               \n",
+       "  │   │   'element_symbol': 'O',                            \n",
+       "  │   │   'coords': array([  6.291, -37.668,   9.239]),     \n",
+       "  │   │   'b_factor': 1.0,                                  \n",
+       "  │   │   'atomic_radius': 0.67                             \n",
+       "  }                                                     \n",
+       "  )                                                         \n",
+       " ╰──────────────────────────────────────────────────────────╯ \n",
+       "                                                              \n",
+       " 31 attribute(s) not shown. Run inspect(inspect) for options. \n",
+       "╰──────────────────────────────────────────────────────────────╯\n",
+       "
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This is a little more involved than a protein structure where we can (almost!) uniquely identify a given residue by `CHAIN:RESIDUE:SEA_POSITION` and a given atom by `CHAIN:RESIDUE:SEQ_POSITION:ATOM_NAME`\n", + "\n", + "For RNA, we adopt a `CHAIN:BASE:SEQ_POSITION:ATOM_NUMBER:ATOM_NAME`. The inclusion of the atom number in the identifier is required due to the possibility of the presence of complementary strand (which is not treated as another chain in the graph). This can be seen clearly in our example (two complementary strands form each chain)" + ] + }, + { + "cell_type": "code", + "execution_count": 16, + "id": "f9b7a9b7", + "metadata": {}, + "outputs": [ + { + "data": { + "application/vnd.plotly.v1+json": { + "config": { + "plotlyServerURL": "https://plot.ly" + }, + "data": [ + { + "hoverinfo": "text+x+y+z", + "marker": { + "color": [ + 203, + 203, + 203, + 203, + 203, + 203, + 203, + 203, + 203, + 203, + 203, + 203, + 203, + 203, + 203, + 203, + 203, + 203, + 203, + 203, + 203, + 203, + 203, + 203, + 203, + 203, + 203, + 203, + 203, + 203, + 203, + 203, + 203, + 203, + 203, + 203, + 203, + 203, + 203, + 203, + 203, + 203, + 203, + 203, + 203, + 203, + 203, + 203, + 203, + 203, + 203, + 203, + 203, + 203, + 203, + 203, + 203, + 203, + 203, + 203, + 203, + 203, + 203, + 203, + 203, + 203, + 203, + 203, + 203, + 203, + 203, + 203, + 203, + 203, + 203, + 203, + 203, + 203, + 203, + 203, + 203, + 203, + 203, + 203, + 203, + 203, + 203, + 203, + 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"white", + "ticks": "", + "title": { + "standoff": 15 + }, + "zerolinecolor": "white", + "zerolinewidth": 2 + } + } + }, + "width": 620 + } + } + }, + "metadata": {}, + "output_type": "display_data" + } + ], + "source": [ + "from functools import partial\n", + "\n", + "config = gr.RNAGraphConfig(\n", + " edge_construction_functions=[\n", + " partial(gr.add_k_nn_edges, k=5, long_interaction_threshold=-1),\n", + " partial(gr.add_distance_threshold, threshold=3, long_interaction_threshold=-1),\n", + " ]\n", + ")\n", + "\n", + "g = gr.construct_graph(pdb_code=\"2jyf\", config=config)\n", + "gr.plotly_rna_structure_graph(g, colour_nodes_by=\"residue_name\", node_size_min=1)" + ] + }, + { + "cell_type": "markdown", + "id": "3bf51368", + "metadata": {}, + "source": [ + "## Extracting Subgraphs from 3D RNA Structure Graphs\n", + "\n", + "We can use graphein's selection capabilities to extract [subgraphs of RNA structures](https://graphein.ai/modules/graphein.rna.html#module-graphein.rna.subgraphs). These functions behave analogously to the [subgraph extraction for proteins]() (see tutorial for more details). However, there are some protein-specific selections and some RNA-specific selections so there is not perfect overlap.\n", + "\n", + "The available methods for RNA structures are:\n", + "\n", + "* [`extract_subgraph_from_node_list()`](https://graphein.ai/modules/graphein.rna.html#graphein.rna.subgraphs.extract_subgraph_from_node_list)\n", + "* [`extract_subgraph_from_backbone()`](https://graphein.ai/modules/graphein.rna.html#graphein.rna.subgraphs.extract_subgraph_from_backbone)\n", + "* [`extract_subgraph_from_bases()`](https://graphein.ai/modules/graphein.rna.html#graphein.rna.subgraphs.extract_subgraph_from_bases)\n", + "* [`extract_subgraph_from_phosphoric_acid()`](https://graphein.ai/modules/graphein.rna.html#graphein.rna.subgraphs.extract_subgraph_from_phosphoric_acid)\n", + "* [`extract_subgraph_from_ribose()`](https://graphein.ai/modules/graphein.rna.html#graphein.rna.subgraphs.extract_subgraph_from_ribose)\n", + "* [`extract_subgraph_from_point()`](https://graphein.ai/modules/graphein.rna.html#graphein.rna.subgraphs.extract_subgraph_from_point)\n", + "* [`extract_subgraph_from_atom_types()`](https://graphein.ai/modules/graphein.rna.html#graphein.rna.subgraphs.extract_subgraph_from_atom_types)\n", + "* [`extract_subgraph_from_residue_types()`](https://graphein.ai/modules/graphein.rna.html#graphein.rna.subgraphs.extract_subgraph_from_residue_types)\n", + "* [`extract_subgraph_from_chains()`](https://graphein.ai/modules/graphein.rna.html#graphein.rna.subgraphs.extract_subgraph_from_chains)\n", + "* [`extract_subgraph_by_sequence_position()`](https://graphein.ai/modules/graphein.rna.html#graphein.rna.subgraphs.extract_subgraph_by_sequence_position)\n", + "* [`extract_subgraph_by_bond_type()`](https://graphein.ai/modules/graphein.rna.html#graphein.rna.subgraphs.extract_subgraph_by_bond_type)\n", + "* [`extract_k_hop_subgraph()`](https://graphein.ai/modules/graphein.rna.html#graphein.rna.subgraphs.extract_k_hop_subgraph)\n", + "\n", + "We illustrate a few examples below\n", + "\n", + "\n", + "### Extracting Backbone Subgraphs" + ] + }, + { + "cell_type": "code", + "execution_count": 18, + "id": "49a30da0", + "metadata": {}, + "outputs": [ + { + "data": { + "application/vnd.plotly.v1+json": { + "config": { + "plotlyServerURL": "https://plot.ly" + }, + "data": [ + { + "hoverinfo": "text+x+y+z", + "marker": { + "color": [ + [ + 0.050383, + 0.029803, + 0.527975, + 1 + ], + [ + 0.050383, + 0.029803, + 0.527975, + 1 + ], + [ + 0.050383, + 0.029803, + 0.527975, + 1 + ], + [ + 0.050383, + 0.029803, + 0.527975, + 1 + ], + [ + 0.050383, + 0.029803, + 0.527975, + 1 + ], + [ + 0.063536, + 0.028426, + 0.533124, + 1 + ], + [ + 0.063536, + 0.028426, + 0.533124, + 1 + ], + [ + 0.063536, + 0.028426, + 0.533124, + 1 + ], + [ + 0.063536, + 0.028426, + 0.533124, + 1 + ], + [ + 0.075353, + 0.027206, + 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gr.extract_subgraph_from_bases(g)\n", + "gr.plotly_rna_structure_graph(s_g, colour_nodes_by=\"seq_position\")" + ] + }, + { + "cell_type": "markdown", + "id": "15a413ea", + "metadata": {}, + "source": [ + "### Extracting Chain Subgraphs\n", + "We can extract subgraphs containing only selections of chains" + ] + }, + { + "cell_type": "code", + "execution_count": 20, + "id": "6d918ab5", + "metadata": {}, + "outputs": [ + { + "data": { + "application/vnd.plotly.v1+json": { + "config": { + "plotlyServerURL": "https://plot.ly" + }, + "data": [ + { + "hoverinfo": "text+x+y+z", + "marker": { + "color": [ + [ + 0.050383, + 0.029803, + 0.527975, + 1 + ], + [ + 0.050383, + 0.029803, + 0.527975, + 1 + ], + [ + 0.050383, + 0.029803, + 0.527975, + 1 + ], + [ + 0.050383, + 0.029803, + 0.527975, + 1 + ], + [ + 0.050383, + 0.029803, + 0.527975, + 1 + ], + [ + 0.050383, + 0.029803, + 0.527975, + 1 + ], + [ + 0.050383, + 0.029803, + 0.527975, + 1 + ], + [ + 0.050383, + 0.029803, + 0.527975, + 1 + ], + [ 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graph with many components (depending on the initial graph construction and the selection method). Using the previous subgraph as an example, we obtain 4 connected components. It is advisable to add new edges if you wish to obtain a graph with one connected component. \n", + "\n", + "In this example we extract a subgraph containing only atoms that are part of the nitrogenous bases. We then add add K-nn edges on top of their covalent structure to result in a connected graph.\n" + ] + }, + { + "cell_type": "code", + "execution_count": 22, + "id": "6355e4fc", + "metadata": {}, + "outputs": [ + { + "name": "stdout", + "output_type": "stream", + "text": [ + "Number of components: 4\n" + ] + } + ], + "source": [ + "import networkx as nx #TODO remove\n", + "print(f\"Number of components: {nx.number_connected_components(s_g)}\")" + ] + }, + { + "cell_type": "code", + "execution_count": 23, + "id": "57981486", + "metadata": {}, + "outputs": [ + { + "name": "stdout", + "output_type": "stream", + "text": [ + "Number of components: 1\n" + ] + }, + { + "data": { + "application/vnd.plotly.v1+json": { + "config": { + "plotlyServerURL": "https://plot.ly" + }, + "data": [ + { + "hoverinfo": "text+x+y+z", + "marker": { + "color": [ + [ + 0.050383, + 0.029803, + 0.527975, + 1 + ], + [ + 0.086222, + 0.026125, + 0.542658, + 1 + ], + [ + 0.115124, + 0.023556, + 0.555468, + 1 + ], + [ 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Saving selections to PDB files\n", + "We can save the selections to a PDB file for use elsewhere in the bioinformatics universe :)\n", + "\n", + "*N.B.* This will not preserve connectivity and metadata" + ] + }, + { + "cell_type": "code", + "execution_count": 24, + "id": "fd15fe6a", + "metadata": {}, + "outputs": [ + { + "name": "stderr", + "output_type": "stream", + "text": [ + "/home/atj39/anaconda3/envs/graphein/lib/python3.8/site-packages/biopandas/pdb/pandas_pdb.py:554: UserWarning:\n", + "\n", + "Column node_id is not an expected column and will be skipped.\n", + "\n" + ] + } + ], + "source": [ + "from graphein.protein.utils import save_graph_to_pdb\n", + "save_graph_to_pdb(s_g, \"selection.pdb\")" + ] + }, + { + "cell_type": "code", + "execution_count": 25, + "id": "7714ac0c", + "metadata": {}, + "outputs": [ + { + "data": { + "application/vnd.plotly.v1+json": { + "config": { + "plotlyServerURL": "https://plot.ly" + }, + "data": [ + { + "hoverinfo": "text+x+y+z", + "marker": { + 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"linecolor": "white", + "ticks": "" + }, + "bgcolor": "#E5ECF6", + "radialaxis": { + "gridcolor": "white", + "linecolor": "white", + "ticks": "" + } + }, + "scene": { + "xaxis": { + "backgroundcolor": "#E5ECF6", + "gridcolor": "white", + "gridwidth": 2, + "linecolor": "white", + "showbackground": true, + "ticks": "", + "zerolinecolor": "white" + }, + "yaxis": { + "backgroundcolor": "#E5ECF6", + "gridcolor": "white", + "gridwidth": 2, + "linecolor": "white", + "showbackground": true, + "ticks": "", + "zerolinecolor": "white" + }, + "zaxis": { + "backgroundcolor": "#E5ECF6", + "gridcolor": "white", + "gridwidth": 2, + "linecolor": "white", + "showbackground": true, + "ticks": "", + "zerolinecolor": "white" + } + }, + "shapedefaults": { + "line": { + "color": "#2a3f5f" + } + }, + "ternary": { + "aaxis": { + "gridcolor": "white", + "linecolor": "white", + "ticks": "" + }, + "baxis": { + "gridcolor": "white", + "linecolor": "white", + "ticks": "" + }, + "bgcolor": "#E5ECF6", + "caxis": { + "gridcolor": "white", + "linecolor": "white", + "ticks": "" + } + }, + "title": { + "x": 0.05 + }, + "xaxis": { + "automargin": true, + "gridcolor": "white", + "linecolor": "white", + "ticks": "", + "title": { + "standoff": 15 + }, + "zerolinecolor": "white", + "zerolinewidth": 2 + }, + "yaxis": { + "automargin": true, + "gridcolor": "white", + "linecolor": "white", + "ticks": "", + "title": { + "standoff": 15 + }, + "zerolinecolor": "white", + "zerolinewidth": 2 + } + } + }, + "width": 620 + } + } + }, + "metadata": {}, + "output_type": "display_data" + } + ], + "source": [ + "# Reading it back in\n", + "g = gr.construct_graph(pdb_path=\"selection.pdb\")\n", + "gr.plotly_rna_structure_graph(g, colour_nodes_by=\"seq_position\")" ] } ], "metadata": { + "interpreter": { + "hash": "0ab7f988027852efc1ebacd06db3f130eb65d2a20cb6a366311359132c20a952" + }, "kernelspec": { - "display_name": "Python 3", + "display_name": "Python 3.8.13 ('graphein')", "language": "python", "name": "python3" }, @@ -183,7 +610648,7 @@ "name": "python", "nbconvert_exporter": "python", "pygments_lexer": "ipython3", - "version": "3.8.12" + "version": "3.8.13" } }, "nbformat": 4, diff --git a/notebooks/splitting_a_dataset.ipynb b/notebooks/splitting_a_dataset.ipynb new file mode 100644 index 00000000..1a1dfb79 --- /dev/null +++ b/notebooks/splitting_a_dataset.ipynb @@ -0,0 +1,286 @@ +{ + "cells": [ + { + "cell_type": "markdown", + "metadata": {}, + "source": [ + "# Splitting a Protein Dataset into Training and Test Sets\n", + "\n", + "Constructing careful splits of protein datasets can be tricky due to sequence homology. Graphein can take care of this for you.\n", + "\n", + "We use BLAST to cluster sequences based on similarity. Disjoint training and test sets can the be constructed from these clusters.\n", + "\n", + "\n", + "We'll run through a small example of 4 sequences which we split into two equally sized training and test sets at 25% identity. We note that this is really the bare minimum one can prevent data leakage due to homology. Here we only account for sequence homology, however even proteins with 0% sequence identity can adopt very similar folds. Features for spltting based on SCOP and CATH annotations are priorities on our development roadmap. For a fuller discussion, see David Jones' excellent treatment of the potential pitfalls when working with machine learning in biology:\n", + "\n", + "> Setting the standards for machine learning in biology\n", + "> David T. Jones\n", + "> Nature Review Molecular Cell Biology\n", + "> https://www.nature.com/articles/s41580-019-0176-5\n", + "\n", + "\n", + "\n", + "[![Open In Colab](https://colab.research.google.com/assets/colab-badge.svg)](https://colab.research.google.com/github/a-r-j/graphein/blob/master/notebooks/splitting_a_dataset.ipynb)\n", + "[![GitHub](https://img.shields.io/badge/-View%20on%20GitHub-181717?logo=github&logoColor=ffffff)](https://github.com/a-r-j/graphein/blob/master/notebooks/splitting_a_dataset.ipynb)\n", + "\n", + "\n", + "## Requirements\n", + "This functionality relies on BLAST. On linux, you can install it with:\n", + "\n", + "```bash\n", + "sudo apt install ncbi-blast+\n", + "```\n", + "\n", + "Otherwise, please see: https://blast.ncbi.nlm.nih.gov/Blast.cgi?CMD=Web&PAGE_TYPE=BlastDocs&DOC_TYPE=Download\n" + ] + }, + { + "cell_type": "code", + "execution_count": null, + "metadata": {}, + "outputs": [], + "source": [ + "# Install graphein if necessary:\n", + "# !pip install graphein\n", + "\n", + "# Install blast if necessary (linux):\n", + "# !sudo apt install ncbi-blast+" + ] + }, + { + "cell_type": "markdown", + "metadata": {}, + "source": [ + "## Building the Dataset FASTA\n", + "First, we need to assemble our sequences into a FASTA file that contains all of our queries.\n", + "\n", + "We can either do this based on a mapping of our own creation from PDBs to sequences or from a list of graphs" + ] + }, + { + "cell_type": "code", + "execution_count": 7, + "metadata": {}, + "outputs": [], + "source": [ + "from graphein.ml.clustering import build_fasta_file_from_mapping\n", + "\n", + "pdb_sequence_mapping = {\n", + " \"3eiy\": \"SFSNVPAGKDLPQDFNVIIEIPAQSEPVKYEADKALGLLVVDRFIGTGMRYPVNYGFIPQTLSGDGDPVDVLVITPFPLLAGSVVRARALGMLKMTDESGVDAKLVAVPHDKVCPMTANLKSIDDVPAYLKDQIKHFFEQYKALEKGKWVKVEGWDGIDAAHKEITDGVANFKK\",\n", + " \"1lds\": \"MIQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWD\",\n", + " \"4hhb\": \"VLSPADKTNVKAAWGKVGAHAGEYGAEALERMFLSFPTTKTYFPHFDLSHGSAQVKGHGKKVADALTNAVAHVDDMPNALSALSDLHAHKLRVDPVNFKLLSHCLLVTLAAHLPAEFTPAVHASLDKFLASVSTVLTSKYR\",\n", + " \"7wda\": \"GLVVSFYTPATDGATFTAIAQRCNQQFGGRFTIAQVSLPRSPNEQRLQLARRLTGNDRTLDVMALDVVWTAEFAEAGWALPLSDDPAGLAENDAVADTLPGPLATAGWNHKLYAAPVTTNTQLLWYRPDLVNSPPTDWNAMIAEAARLHAAGEPSWIAVQANQGEGLVVWFNTLLVSAGGSVLSEDGRHVTLTDTPAHRAATVSALQILKSVATTPGADPSITRTEEGSARLAFEQGKAALEVNWPFVFASMLENAVKGGVPFLPLNRIPQLAGSINDIGTFTPSDEQFRIAYDASQQVFGFAPYPAVAPGQPAKVTIGGLNLAVAKTTRHRAEAFEAVRCLRDQHNQRYVSLEGGLPAVRASLYSDPQFQAKYPMHAIIRQQLTDAAVRPATPVYQALSIRLAAVLSPITEIDPESTADELAAQAQKAIDG\"\n", + " }\n", + "\n", + "build_fasta_file_from_mapping(pdb_sequence_mapping, \"sequences.fasta\")" + ] + }, + { + "cell_type": "code", + "execution_count": 13, + "metadata": {}, + "outputs": [ + { + "data": { + "text/html": [ + "
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+       "
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+      ],
+      "text/plain": []
+     },
+     "metadata": {},
+     "output_type": "display_data"
+    },
+    {
+     "data": {
+      "text/html": [
+       "
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+       "
\n" + ], + "text/plain": [ + "\n" + ] + }, + "metadata": {}, + "output_type": "display_data" + } + ], + "source": [ + "# We could also build this mapping from a list of graphs\n", + "import graphein.protein as gp\n", + "from graphein.ml.clustering import build_fasta_file_from_graphs\n", + "\n", + "# Build graphs\n", + "graphs = [gp.construct_graph(pdb_code=code) for code in [\"3eiy\", \"1lds\", \"4hhb\", \"7wda\"]]\n", + "\n", + "# Build fasta\n", + "build_fasta_file_from_graphs(graphs, fasta_out=\"sequences.fasta\", chains=[\"A\", \"A\", \"A\", \"A\"]) # Chain param lets us select a specific chain in a structure" + ] + }, + { + "cell_type": "code", + "execution_count": 14, + "metadata": {}, + "outputs": [ + { + "name": "stdout", + "output_type": "stream", + "text": [ + ">3eiy_A\n", + "SFSNVPAGKDLPQDFNVIIEIPAQSEPVKYEADKALGLLVVDRFIGTGMRYPVNYGFIPQTLSGDGDPVDVLVITPFPLLAGSVVRARALGMLKMTDESGVDAKLVAVPHDKVCPMTANLKSIDDVPAYLKDQIKHFFEQYKALEKGKWVKVEGWDGIDAAHKEITDGVANFKK\n", + ">1lds_A\n", + "MIQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWD\n", + ">4hhb_A\n", + "VLSPADKTNVKAAWGKVGAHAGEYGAEALERMFLSFPTTKTYFPHFDLSHGSAQVKGHGKKVADALTNAVAHVDDMPNALSALSDLHAHKLRVDPVNFKLLSHCLLVTLAAHLPAEFTPAVHASLDKFLASVSTVLTSKYR\n", + ">7wda_A\n", + "GLVVSFYTPATDGATFTAIAQRCNQQFGGRFTIAQVSLPRSPNEQRLQLARRLTGNDRTLDVMALDVVWTAEFAEAGWALPLSDDPAGLAENDAVADTLPGPLATAGWNHKLYAAPVTTNTQLLWYRPDLVNSPPTDWNAMIAEAARLHAAGEPSWIAVQANQGEGLVVWFNTLLVSAGGSVLSEDGRHVTLTDTPAHRAATVSALQILKSVATTPGADPSITRTEEGSARLAFEQGKAALEVNWPFVFASMLENAVKGGVPFLPLNRIPQLAGSINDIGTFTPSDEQFRIAYDASQQVFGFAPYPAVAPGQPAKVTIGGLNLAVAKTTRHRAEAFEAVRCLRDQHNQRYVSLEGGLPAVRASLYSDPQFQAKYPMHAIIRQQLTDAAVRPATPVYQALSIRLAAVLSPITEIDPESTADELAAQAQKAIDG\n", + "\n" + ] + } + ], + "source": [ + "# Inspect the FASTA file:\n", + "with open(\"sequences.fasta\", \"r\") as f:\n", + " print(f.read())" + ] + }, + { + "cell_type": "markdown", + "metadata": {}, + "source": [ + "## Clustering the Data" + ] + }, + { + "cell_type": "code", + "execution_count": 11, + "metadata": {}, + "outputs": [ + { + "name": "stdout", + "output_type": "stream", + "text": [ + "Clustering proteins by sequence identity\n", + "----------------------------------------\n", + "Parameters:\n", + " - Number of sets to split: 1\n", + " - Sequence identity low threshold: 25.0%\n", + " - Fraction of sequences in test set: 0.5\n", + "\n", + "\n", + "*** Creating sequences pairs for clustering\n", + "\n", + "\n", + "Building a new DB, current time: 05/18/2022 18:38:39\n", + "New DB name: /home/atj39/github/graphein/notebooks/sequences.fasta\n", + "New DB title: sequences.fasta\n", + "Sequence type: Protein\n", + "Keep MBits: T\n", + "Maximum file size: 1000000000B\n", + "Adding sequences from FASTA; added 4 sequences in 0.000277042 seconds.\n", + "*** Clustering from pairs of sequences\n", + "*** Generating sets\n", + "4 ids in 4 clusters\n", + "Generated set LR_00 and TS_00 - 2 sequences for 2 clusters in test, among (4, 4) in total. Test relative size is 0.5\n" + ] + }, + { + "data": { + "text/plain": [ + "['4hhb', '3eiy']" + ] + }, + "execution_count": 11, + "metadata": {}, + "output_type": "execute_result" + } + ], + "source": [ + "from graphein.ml.clustering import train_and_test_from_fasta\n", + "\n", + "train_and_test_from_fasta(fasta_file=\"sequences.fasta\", number_of_sets=1, fraction_in_test=0.5,\n", + " cluster_file_name='s2d_clusters.txt', seq_id_low_thresh=25.,\n", + " use_very_loose_condition=False, n_cpu=2,\n", + " max_target_seqs=200, delete_db_when_done=True,\n", + " train_set_key='LR', test_set_key='TS', early_break=True\n", + " )\n" + ] + }, + { + "cell_type": "markdown", + "metadata": {}, + "source": [ + "## Inspecting the split" + ] + }, + { + "cell_type": "code", + "execution_count": 12, + "metadata": {}, + "outputs": [ + { + "name": "stdout", + "output_type": "stream", + "text": [ + "Train Data:\n", + "1lds\n", + "7wda\n", + "\n", + "Test Data:\n", + "4hhb\n", + "3eiy\n", + "\n" + ] + } + ], + "source": [ + "# Train Data\n", + "print(\"Train Data:\")\n", + "with open(\"LR_00\", \"r\") as f:\n", + " print(f.read())\n", + "\n", + "# Test Data\n", + "print(\"Test Data:\")\n", + "with open(\"TS_00\", \"r\") as f:\n", + " print(f.read())" + ] + } + ], + "metadata": { + "interpreter": { + "hash": "0ab7f988027852efc1ebacd06db3f130eb65d2a20cb6a366311359132c20a952" + }, + "kernelspec": { + "display_name": "Python 3.8.13 ('graphein')", + "language": "python", + "name": "python3" + }, + "language_info": { + "codemirror_mode": { + "name": "ipython", + "version": 3 + }, + "file_extension": ".py", + "mimetype": "text/x-python", + "name": "python", + "nbconvert_exporter": "python", + "pygments_lexer": "ipython3", + "version": "3.8.13" + }, + "orig_nbformat": 4 + }, + "nbformat": 4, + "nbformat_minor": 2 +} diff --git a/notebooks/tdc_developability.ipynb b/notebooks/tdc_developability.ipynb new file mode 100644 index 00000000..8e315e8e --- /dev/null +++ b/notebooks/tdc_developability.ipynb @@ -0,0 +1,12508 @@ +{ + "cells": [ + { + "cell_type": "markdown", + "metadata": {}, + "source": [ + "# Antibody Developability Prediction with E(N) GNNs\n", + "\n", + "Here we showcase Graphein's ability to generate a structural dataset from only PDB identifiers and labels. We use an [antibody developability dataset](https://tdcommons.ai/single_pred_tasks/develop/) from [TDC](https://tdcommons.ai/) and train an [E(N) GNN](https://arxiv.org/abs/2102.09844) on antibody structure graphs.\n", + "\n", + "**Dataset Description**: Antibody data from Chen et al [1], where they process from the SAbDab [2]. From an initial dataset of 3816 antibodies, they retained 2426 antibodies that satisfy the following criteria:\n", + "\n", + "1. have both sequence (FASTA) and Protein Data Bank (PDB) structure files,\n", + "2. contain both a heavy chain and a light chain, and\n", + "3. have crystal structures with resolution < 3 Å. The DI label is derived from BIOVIA's pipelines [3].\n", + "\n", + "**Task Description**: Binary classification. Given the antibody's heavy chain and light chain sequence, predict its developability. The input X is a list of two sequences where the first is the heavy chain and the second light chain.\n", + "\n", + "**Dataset Statistics**: 2,409 antibodies.\n", + "\n", + "**Dataset Split**: Random Split\n", + "\n", + "**References**:\n", + "\n", + "[1] Chen, Xingyao, et al. “Predicting antibody developability from sequence using machine learning.” bioRxiv (2020).\n", + "\n", + "[2] Dunbar, James, et al. “SAbDab: the structural antibody database.” Nucleic acids research 42.D1 (2014): D1140-D1146.\n", + "\n", + "[3] Biovia, Dassault Systèmes. “BIOVIA pipeline pilot.” Dassault Systèmes: San Diego, BW, Release (2017).\n", + "\n", + "[![Open In Colab](https://colab.research.google.com/assets/colab-badge.svg)](https://colab.research.google.com/github/a-r-j/graphein/blob/master/notebooks/tdc_developability.ipynb) [![GitHub](https://img.shields.io/badge/-View%20on%20GitHub-181717?logo=github&logoColor=ffffff)](https://github.com/a-r-j/graphein/blob/master/notebooks/tdc_developability.ipynb)" + ] + }, + { + "cell_type": "code", + "execution_count": 1, + "metadata": {}, + "outputs": [], + "source": [ + "# Install requirements if necessary\n", + "# !pip install graphein\n", + "# !pip install PyTDC" + ] + }, + { + "cell_type": "code", + "execution_count": 2, + "metadata": {}, + "outputs": [ + { + "name": "stderr", + "output_type": "stream", + "text": [ + "To use the Graphein submodule graphein.protein.visualisation, you need to install: pytorch3d \n", + "To do so, use the following command: conda install -c pytorch3d pytorch3d\n" + ] + }, + { + "data": { + "text/html": [ + "
[05/19/22 16:23:54] WARNING  To use the Graphein submodule                       meshes.py:29\n",
+                            "                             graphein.protein.meshes, you need to install:                   \n",
+                            "                             pytorch3d                                                       \n",
+                            "                             To do so, use the following command: conda install              \n",
+                            "                             -c pytorch3d pytorch3d                                          \n",
+                            "
\n" + ], + "text/plain": [ + "\u001b[2;36m[05/19/22 16:23:54]\u001b[0m\u001b[2;36m \u001b[0m\u001b[31mWARNING \u001b[0m To use the Graphein submodule \u001b]8;id=951769;file:///home/atj39/github/graphein/graphein/protein/meshes.py\u001b\\\u001b[2mmeshes.py\u001b[0m\u001b]8;;\u001b\\\u001b[2m:\u001b[0m\u001b]8;id=789142;file:///home/atj39/github/graphein/graphein/protein/meshes.py#29\u001b\\\u001b[2m29\u001b[0m\u001b]8;;\u001b\\\n", + "\u001b[2;36m \u001b[0m graphein.protein.meshes, you need to install: \u001b[2m \u001b[0m\n", + "\u001b[2;36m \u001b[0m pytorch3d \u001b[2m \u001b[0m\n", + "\u001b[2;36m \u001b[0m To do so, use the following command: conda install \u001b[2m \u001b[0m\n", + "\u001b[2;36m \u001b[0m -c pytorch3d pytorch3d \u001b[2m \u001b[0m\n" + ] + }, + "metadata": {}, + "output_type": "display_data" + } + ], + "source": [ + "#NBVAL_SKIP\n", + "import torch\n", + "from typing import Dict\n", + "\n", + "from tdc.single_pred import Develop\n", + "\n", + "import graphein.protein as gp\n", + "from graphein.ml.conversion import GraphFormatConvertor\n", + "from graphein.ml import InMemoryProteinGraphDataset, ProteinGraphDataset" + ] + }, + { + "cell_type": "markdown", + "metadata": {}, + "source": [ + "## Loading Data from TDC\n", + "As this dataset is non-redundant we can use a random split" + ] + }, + { + "cell_type": "code", + "execution_count": 58, + "metadata": {}, + "outputs": [ + { + "name": "stderr", + "output_type": "stream", + "text": [ + "Found local copy...\n", + "Loading...\n", + "Done!\n" + ] + }, + { + "data": { + "text/html": [ + "
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" + ], + "text/plain": [ + " Antibody_ID Antibody Y\n", + "0 12e8 ['EVQLQQSGAEVVRSGASVKLSCTASGFNIKDYYIHWVKQRPEKG... 0\n", + "1 15c8 ['EVQLQQSGAELVKPGASVKLSCTASGFNIKDTYMHWVKQKPEQG... 0\n", + "2 1a0q ['EVQLQESDAELVKPGASVKISCKASGYTFTDHVIHWVKQKPEQG... 1\n", + "3 1a14 ['QVQLQQSGAELVKPGASVRMSCKASGYTFTNYNMYWVKQSPGQG... 0\n", + "4 1a2y ['QVQLQESGPGLVAPSQSLSITCTVSGFSLTGYGVNWVRQPPGKG... 0" + ] + }, + "execution_count": 58, + "metadata": {}, + "output_type": "execute_result" + } + ], + "source": [ + "#NBVAL_SKIP\n", + "# Load data from TDC and split\n", + "data = Develop(name = 'SAbDab_Chen')\n", + "split = data.get_split()\n", + "split[\"train\"].head()" + ] + }, + { + "cell_type": "markdown", + "metadata": {}, + "source": [ + "## Removing Obsolete Structures\n", + "\n", + "Sometimes PDB entries are made obsolete as improved structures are made available. This is problematic as the old structures are not available for download. For instance, see [1OM3](https://www.rcsb.org/structure/removed/1OM3) which has been replaced by [6N32](https://www.rcsb.org/structure/6N32)." + ] + }, + { + "cell_type": "code", + "execution_count": 4, + "metadata": {}, + "outputs": [ + { + "name": "stdout", + "output_type": "stream", + "text": [ + "['1om3', '1zls', '1zlu', '1zlw', '3l5y', '3qot', '3rvv', '3rvw', '3rvx', '3wxw', '4nx3', '4pp2', '4x4y', '5kmv', '5usi', '6erx']\n", + "[]\n", + "['3wxv', '1zlv', '1op3', '3qos']\n" + ] + } + ], + "source": [ + "#NBVAL_SKIP\n", + "# Check for obsolete structures\n", + "from graphein.protein.utils import get_obsolete_mapping\n", + "\n", + "obs = get_obsolete_mapping()\n", + "\n", + "train_obs = [t for t in split[\"train\"][\"Antibody_ID\"] if t in obs.keys()]\n", + "valid_obs = [t for t in split[\"valid\"][\"Antibody_ID\"] if t in obs.keys()]\n", + "test_obs = [t for t in split[\"test\"][\"Antibody_ID\"] if t in obs.keys()]\n", + "\n", + "print(train_obs)\n", + "print(valid_obs)\n", + "print(test_obs)" + ] + }, + { + "cell_type": "code", + "execution_count": 5, + "metadata": {}, + "outputs": [ + { + "name": "stdout", + "output_type": "stream", + "text": [ + "Replacement PDBs: ['6n32', '6msy', '6mub', '6mnf', '4ps4', '5i18', '5vpl', '5vpg', '5vph', '6ks1', '4web', '5vco', '6dn0', '5vzx', '6b9j', '6fxn']\n" + ] + } + ], + "source": [ + "#NBVAL_SKIP\n", + "# If you want, you can get the PDB IDs of the new structure that replaces the obsolete entry\n", + "print(\"Replacement PDBs: \", [obs[t] for t in train_obs])\n", + "\n", + "# However, in this instance we will simply remove the obsolete entries from the train and test sets.\n", + "split[\"train\"] = split[\"train\"].loc[~split[\"train\"][\"Antibody_ID\"].isin(train_obs)]\n", + "split[\"test\"] = split[\"test\"].loc[~split[\"test\"][\"Antibody_ID\"].isin(test_obs)]" + ] + }, + { + "cell_type": "markdown", + "metadata": {}, + "source": [ + "## Creating Labels\n", + "\n", + "We convert the labels to tensors and map them to their corresponding PDB ID." + ] + }, + { + "cell_type": "code", + "execution_count": 6, + "metadata": {}, + "outputs": [], + "source": [ + "#NBVAL_SKIP\n", + "# Convert labels to tensors\n", + "def get_label_map(split_name: str) -> Dict[str, torch.Tensor]:\n", + " return dict(zip(split[split_name].Antibody_ID, split[split_name].Y.apply(torch.tensor)))\n", + "\n", + "train_labels = get_label_map(\"train\")\n", + "valid_labels = get_label_map(\"valid\")\n", + "test_labels = get_label_map(\"test\")" + ] + }, + { + "cell_type": "markdown", + "metadata": {}, + "source": [ + "## Creating Graphs and Dataloaders with Graphein\n", + "\n", + "### Configuration and Conversion\n", + "\n", + "First, we define a [configuration object](https://graphein.ai/modules/graphein.protein.html#graphein.protein.config.ProteinGraphConfig) which governs the graph construction. Here we use a simple graph for illustrative purposes, using only a one-hot encoding of the amino acid type, the node coordinates and edges based on spatial contacts within 6 angstroms.\n", + "\n", + "Secondly, we define a [convertor](https://graphein.ai/modules/graphein.ml.html#conversion) which converts from NetworkX graphs to Pytorch Geometric `Data` objects." + ] + }, + { + "cell_type": "code", + "execution_count": 7, + "metadata": {}, + "outputs": [], + "source": [ + "#NBVAL_SKIP\n", + "from functools import partial\n", + "\n", + "graphein_config = gp.ProteinGraphConfig(\n", + " node_metadata_functions=[gp.amino_acid_one_hot],\n", + " edge_construction_functions=[partial(gp.add_distance_threshold, threshold=6, long_interaction_threshold=0)])\n", + "\n", + "convertor = GraphFormatConvertor(src_format=\"nx\", dst_format=\"pyg\", columns=[\"coords\", \"edge_index\", \"amino_acid_one_hot\"])" + ] + }, + { + "cell_type": "code", + "execution_count": 8, + "metadata": {}, + "outputs": [ + { + "data": { + "text/html": [ + "
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"#E5ECF6", + "caxis": { + "gridcolor": "white", + "linecolor": "white", + "ticks": "" + } + }, + "title": { + "x": 0.05 + }, + "xaxis": { + "automargin": true, + "gridcolor": "white", + "linecolor": "white", + "ticks": "", + "title": { + "standoff": 15 + }, + "zerolinecolor": "white", + "zerolinewidth": 2 + }, + "yaxis": { + "automargin": true, + "gridcolor": "white", + "linecolor": "white", + "ticks": "", + "title": { + "standoff": 15 + }, + "zerolinecolor": "white", + "zerolinewidth": 2 + } + } + }, + "width": 620 + } + } + }, + "metadata": {}, + "output_type": "display_data" + } + ], + "source": [ + "#NBVAL_SKIP\n", + "# Quickly visualise a protein to see what the config looks like in practice\n", + "gp.plotly_protein_structure_graph(gp.construct_graph(pdb_code=\"1lds\", config=graphein_config))" + ] + }, + { + "cell_type": "markdown", + "metadata": {}, + "source": [ + "### Creating Datasets\n", + "\n", + "Next, we create the actual structural datasets. This takes care of downloading the raw structural data, pre-processing, graph conversion and caches the dataset for easy access." + ] + }, + { + "cell_type": "code", + "execution_count": 9, + "metadata": {}, + "outputs": [], + "source": [ + "#NBVAL_SKIP\n", + "train_ds = InMemoryProteinGraphDataset(\n", + " root=\"./data/\",\n", + " name=\"train\",\n", + " pdb_codes=split[\"train\"][\"Antibody_ID\"],\n", + " graph_label_map=train_labels,\n", + " graphein_config=graphein_config,\n", + " graph_format_convertor=convertor\n", + " )\n", + "\n", + "valid_ds = InMemoryProteinGraphDataset(\n", + " root=\"./data/\",\n", + " name=\"valid\",\n", + " pdb_codes=split[\"valid\"][\"Antibody_ID\"],\n", + " graph_label_map=valid_labels,\n", + " graphein_config=graphein_config,\n", + " graph_format_convertor=convertor\n", + " )\n", + "\n", + "test_ds = InMemoryProteinGraphDataset(\n", + " root=\"./data/\",\n", + " name=\"test\",\n", + " pdb_codes=split[\"test\"][\"Antibody_ID\"],\n", + " graph_label_map=test_labels,\n", + " graphein_config=graphein_config,\n", + " graph_format_convertor=convertor\n", + " )" + ] + }, + { + "cell_type": "markdown", + "metadata": {}, + "source": [ + "Next, we wrap the datasets to create dataloaders for our model." + ] + }, + { + "cell_type": "code", + "execution_count": 10, + "metadata": {}, + "outputs": [], + "source": [ + "#NBVAL_SKIP\n", + "from torch_geometric.loader import DataLoader\n", + "\n", + "# Create dataloaders\n", + "train_loader = DataLoader(train_ds, batch_size=16, shuffle=False, drop_last=True)\n", + "valid_loader = DataLoader(valid_ds, batch_size=16, shuffle=False, drop_last=True)\n", + "test_loader = DataLoader(test_ds, batch_size=16, drop_last=True)" + ] + }, + { + "cell_type": "code", + "execution_count": 11, + "metadata": {}, + "outputs": [ + { + "name": "stdout", + "output_type": "stream", + "text": [ + "DataBatch(edge_index=[2, 40070], node_id=[16], coords=[16], amino_acid_one_hot=[16], graph_y=[16], num_nodes=11545, batch=[11545], ptr=[17])\n" + ] + } + ], + "source": [ + "#NBVAL_SKIP\n", + "# Inspect a batch\n", + "for b in valid_loader:\n", + " print(b)\n", + " break" + ] + }, + { + "cell_type": "markdown", + "metadata": {}, + "source": [ + "## Model\n", + "\n", + "Here we lift the implementation from the github repository accompanying the paper https://github.com/vgsatorras/egnn" + ] + }, + { + "cell_type": "code", + "execution_count": 12, + "metadata": {}, + "outputs": [], + "source": [ + "#NBVAL_SKIP\n", + "import pytorch_lightning as pl\n", + "import torch\n", + "import torch.nn as nn\n", + "import itertools" + ] + }, + { + "cell_type": "code", + "execution_count": 13, + "metadata": {}, + "outputs": [], + "source": [ + "#NBVAL_SKIP\n", + "\"\"\"EGNN Implementation from Satorras et al. https://github.com/vgsatorras/egnn\"\"\"\n", + "\n", + "class E_GCL(nn.Module):\n", + " \"\"\"\n", + " E(n) Equivariant Convolutional Layer\n", + " re\n", + " \"\"\"\n", + "\n", + " def __init__(self, input_nf, output_nf, hidden_nf, edges_in_d=0, act_fn=nn.SiLU(), residual=True, attention=False, normalize=False, coords_agg='mean', tanh=False):\n", + " super(E_GCL, self).__init__()\n", + " input_edge = input_nf * 2\n", + " self.residual = residual\n", + " self.attention = attention\n", + " self.normalize = normalize\n", + " self.coords_agg = coords_agg\n", + " self.tanh = tanh\n", + " self.epsilon = 1e-8\n", + " edge_coords_nf = 1\n", + "\n", + " self.edge_mlp = nn.Sequential(\n", + " nn.Linear(input_edge + edge_coords_nf + edges_in_d, hidden_nf),\n", + " act_fn,\n", + " nn.Linear(hidden_nf, hidden_nf),\n", + " act_fn)\n", + "\n", + " self.node_mlp = nn.Sequential(\n", + " nn.Linear(hidden_nf + input_nf, hidden_nf),\n", + " act_fn,\n", + " nn.Linear(hidden_nf, output_nf))\n", + "\n", + " layer = nn.Linear(hidden_nf, 1, bias=False)\n", + " torch.nn.init.xavier_uniform_(layer.weight, gain=0.001)\n", + "\n", + " coord_mlp = [nn.Linear(hidden_nf, hidden_nf)]\n", + " coord_mlp.append(act_fn)\n", + " coord_mlp.append(layer)\n", + " if self.tanh:\n", + " coord_mlp.append(nn.Tanh())\n", + " self.coord_mlp = nn.Sequential(*coord_mlp)\n", + "\n", + " if self.attention:\n", + " self.att_mlp = nn.Sequential(\n", + " nn.Linear(hidden_nf, 1),\n", + " nn.Sigmoid())\n", + "\n", + " def edge_model(self, source, target, radial, edge_attr):\n", + " if edge_attr is None: # Unused.\n", + " out = torch.cat([source, target, radial], dim=1)\n", + " else:\n", + " out = torch.cat([source, target, radial, edge_attr], dim=1)\n", + " out = self.edge_mlp(out)\n", + " if self.attention:\n", + " att_val = self.att_mlp(out)\n", + " out = out * att_val\n", + " return out\n", + "\n", + " def node_model(self, x, edge_index, edge_attr, node_attr):\n", + " row, col = edge_index\n", + " agg = unsorted_segment_sum(edge_attr, row, num_segments=x.size(0))\n", + " if node_attr is not None:\n", + " agg = torch.cat([x, agg, node_attr], dim=1)\n", + " else:\n", + " agg = torch.cat([x, agg], dim=1)\n", + " out = self.node_mlp(agg)\n", + " if self.residual:\n", + " out = x + out\n", + " return out, agg\n", + "\n", + " def coord_model(self, coord, edge_index, coord_diff, edge_feat):\n", + " row, col = edge_index\n", + " trans = coord_diff * self.coord_mlp(edge_feat)\n", + " if self.coords_agg == 'sum':\n", + " agg = unsorted_segment_sum(trans, row, num_segments=coord.size(0))\n", + " elif self.coords_agg == 'mean':\n", + " agg = unsorted_segment_mean(trans, row, num_segments=coord.size(0))\n", + " else:\n", + " raise Exception('Wrong coords_agg parameter' % self.coords_agg)\n", + " coord += agg\n", + " return coord\n", + "\n", + " def coord2radial(self, edge_index, coord):\n", + " row, col = edge_index\n", + " coord_diff = coord[row] - coord[col]\n", + " radial = torch.sum(coord_diff**2, 1).unsqueeze(1)\n", + "\n", + " if self.normalize:\n", + " norm = torch.sqrt(radial).detach() + self.epsilon\n", + " coord_diff = coord_diff / norm\n", + "\n", + " return radial, coord_diff\n", + "\n", + " def forward(self, h, edge_index, coord, edge_attr=None, node_attr=None):\n", + " row, col = edge_index\n", + " radial, coord_diff = self.coord2radial(edge_index, coord)\n", + "\n", + " edge_feat = self.edge_model(h[row], h[col], radial, edge_attr)\n", + " coord = self.coord_model(coord, edge_index, coord_diff, edge_feat)\n", + " h, agg = self.node_model(h, edge_index, edge_feat, node_attr)\n", + "\n", + " return h, coord, edge_attr\n", + "\n", + "class EGNN(nn.Module):\n", + " def __init__(self, in_node_nf, hidden_nf, out_node_nf, in_edge_nf=0, device='cpu', act_fn=nn.SiLU(), n_layers=4, residual=True, attention=False, normalize=False, tanh=False):\n", + " '''\n", + " :param in_node_nf: Number of features for 'h' at the input\n", + " :param hidden_nf: Number of hidden features\n", + " :param out_node_nf: Number of features for 'h' at the output\n", + " :param in_edge_nf: Number of features for the edge features\n", + " :param device: Device (e.g. 'cpu', 'cuda:0',...)\n", + " :param act_fn: Non-linearity\n", + " :param n_layers: Number of layer for the EGNN\n", + " :param residual: Use residual connections, we recommend not changing this one\n", + " :param attention: Whether using attention or not\n", + " :param normalize: Normalizes the coordinates messages such that:\n", + " instead of: x^{l+1}_i = x^{l}_i + Σ(x_i - x_j)phi_x(m_ij)\n", + " we get: x^{l+1}_i = x^{l}_i + Σ(x_i - x_j)phi_x(m_ij)/||x_i - x_j||\n", + " We noticed it may help in the stability or generalization in some future works.\n", + " We didn't use it in our paper.\n", + " :param tanh: Sets a tanh activation function at the output of phi_x(m_ij). I.e. it bounds the output of\n", + " phi_x(m_ij) which definitely improves in stability but it may decrease in accuracy.\n", + " We didn't use it in our paper.\n", + " '''\n", + "\n", + " super(EGNN, self).__init__()\n", + " self.hidden_nf = hidden_nf\n", + " self.device = device\n", + " self.n_layers = n_layers\n", + " self.embedding_in = nn.Linear(in_node_nf, self.hidden_nf)\n", + " self.embedding_out = nn.Linear(self.hidden_nf, out_node_nf)\n", + " for i in range(n_layers):\n", + " self.add_module(\"gcl_%d\" % i, E_GCL(self.hidden_nf, self.hidden_nf, self.hidden_nf, edges_in_d=in_edge_nf,\n", + " act_fn=act_fn, residual=residual, attention=attention,\n", + " normalize=normalize, tanh=tanh))\n", + " self.to(self.device)\n", + "\n", + " def forward(self, h, x, edges, edge_attr):\n", + " h = self.embedding_in(h)\n", + " for i in range(self.n_layers):\n", + " h, x, _ = self._modules[\"gcl_%d\" % i](h, edges, x, edge_attr=edge_attr)\n", + " h = self.embedding_out(h)\n", + " return h, x\n", + "\n", + "\n", + "def unsorted_segment_sum(data, segment_ids, num_segments):\n", + " result_shape = (num_segments, data.size(1))\n", + " result = data.new_full(result_shape, 0) # Init empty result tensor.\n", + " segment_ids = segment_ids.unsqueeze(-1).expand(-1, data.size(1))\n", + " result.scatter_add_(0, segment_ids, data)\n", + " return result\n", + "\n", + "\n", + "def unsorted_segment_mean(data, segment_ids, num_segments):\n", + " result_shape = (num_segments, data.size(1))\n", + " segment_ids = segment_ids.unsqueeze(-1).expand(-1, data.size(1))\n", + " result = data.new_full(result_shape, 0) # Init empty result tensor.\n", + " count = data.new_full(result_shape, 0)\n", + " result.scatter_add_(0, segment_ids, data)\n", + " count.scatter_add_(0, segment_ids, torch.ones_like(data))\n", + " return result / count.clamp(min=1)\n", + "\n", + "\n", + "def get_edges(n_nodes):\n", + " rows, cols = [], []\n", + " for i, j in itertools.product(range(n_nodes), range(n_nodes)):\n", + " if i != j:\n", + " rows.append(i)\n", + " cols.append(j)\n", + "\n", + " return [rows, cols]\n", + "\n", + "\n", + "def get_edges_batch(n_nodes, batch_size):\n", + " edges = get_edges(n_nodes)\n", + " edge_attr = torch.ones(len(edges[0]) * batch_size, 1)\n", + " edges = [torch.LongTensor(edges[0]), torch.LongTensor(edges[1])]\n", + " if batch_size == 1:\n", + " return edges, edge_attr\n", + " elif batch_size > 1:\n", + " rows, cols = [], []\n", + " for i in range(batch_size):\n", + " rows.append(edges[0] + n_nodes * i)\n", + " cols.append(edges[1] + n_nodes * i)\n", + " edges = [torch.cat(rows), torch.cat(cols)]\n", + " return edges, edge_attr" + ] + }, + { + "cell_type": "code", + "execution_count": 54, + "metadata": {}, + "outputs": [], + "source": [ + "#NBVAL_SKIP\n", + "import torch\n", + "import torch.nn as nn\n", + "from torch_geometric.loader import DataLoader\n", + "from torch_geometric.data import Data\n", + "from torch.nn.functional import binary_cross_entropy_with_logits, mse_loss\n", + "from torch_geometric.nn import global_add_pool\n", + "import pytorch_lightning as pl\n", + "#from torchmetrics import F1Score, Accuracy, AUROC\n", + "from pytorch_lightning.loggers import WandbLogger\n", + "\n", + "\n", + "class SimpleEGNN(pl.LightningModule):\n", + " def __init__(self):\n", + " super().__init__()\n", + " self.model = EGNN(\n", + " in_node_nf=20,\n", + " out_node_nf=32,\n", + " in_edge_nf=0,\n", + " hidden_nf=32,\n", + " n_layers=2,\n", + " )\n", + " self.decoder = nn.Sequential(\n", + " nn.Linear(32, 32),\n", + " nn.ReLU(),\n", + " nn.Linear(32, 1),\n", + " )\n", + " self.loss = binary_cross_entropy_with_logits\n", + "\n", + " def configure_loss(self, name: str):\n", + " \"\"\"Return the loss function based on the config.\"\"\"\n", + " return self.loss\n", + "\n", + " # --- Forward pass\n", + " def forward(self, x):\n", + " x.aa = torch.cat([torch.tensor(a) for a in x.amino_acid_one_hot]).float().cuda()\n", + " x.c = torch.cat([torch.tensor(a).squeeze(0) for a in x.coords]).float().cuda()\n", + " feats, coords = self.model(\n", + " h=x.aa,\n", + " x=x.c,\n", + " edges=x.edge_index,\n", + " edge_attr=None,\n", + " )\n", + " feats = global_add_pool(feats, x.batch)\n", + " return self.decoder(feats)\n", + "\n", + " def training_step(self, batch: Data, batch_idx) -> torch.Tensor:\n", + " x = batch\n", + " y = batch.graph_y.unsqueeze(1).float()\n", + " y_hat = self(x)\n", + "\n", + " loss = self.loss(y_hat, y)\n", + " return loss\n", + "\n", + " def validation_step(self, batch, batch_idx):\n", + " x = batch\n", + " y = batch.graph_y.unsqueeze(1).float()\n", + " y_hat = self(batch)\n", + "\n", + " def test_step(self, batch, batch_idx):\n", + " x = batch\n", + " y = batch.graph_y.unsqueeze(1).float()\n", + " y_hat = self(x)\n", + " loss = self.loss(y_hat, y)\n", + "\n", + " y_pred_softmax = torch.log_softmax(y_hat, dim = 1)\n", + " y_pred_tags = torch.argmax(y_pred_softmax, dim = 1)\n", + " self.log(\"test_loss\", loss)\n", + " #return loss\n", + "\n", + " def configure_optimizers(self) -> torch.optim.Optimizer:\n", + " return torch.optim.Adam(params=self.parameters(), lr=0.001)" + ] + }, + { + "cell_type": "code", + "execution_count": 55, + "metadata": {}, + "outputs": [ + { + "name": "stderr", + "output_type": "stream", + "text": [ + "GPU available: True, used: True\n", + "TPU available: False, using: 0 TPU cores\n", + "IPU available: False, using: 0 IPUs\n", + "HPU available: False, using: 0 HPUs\n" + ] + } + ], + "source": [ + "#NBVAL_SKIP\n", + "trainer = pl.Trainer(\n", + " strategy=None,\n", + " gpus=1,\n", + " benchmark=True,\n", + " deterministic=False,\n", + " num_sanity_val_steps=0,\n", + " max_epochs=10,\n", + ")" + ] + }, + { + "cell_type": "code", + "execution_count": 56, + "metadata": {}, + "outputs": [ + { + "name": "stderr", + "output_type": "stream", + "text": [ + "LOCAL_RANK: 0 - CUDA_VISIBLE_DEVICES: [0,1]\n", + "\n", + " | Name | Type | Params\n", + "---------------------------------------\n", + "0 | model | EGNN | 16.5 K\n", + "1 | decoder | Sequential | 1.1 K \n", + "---------------------------------------\n", + "17.6 K Trainable params\n", + "0 Non-trainable params\n", + "17.6 K Total params\n", + "0.070 Total estimated model params size (MB)\n" + ] + }, + { + "name": "stdout", + "output_type": "stream", + "text": [ + "Epoch 9: 100%|██████████| 119/119 [00:09<00:00, 12.41it/s, loss=0.551, v_num=12]\n" + ] + } + ], + "source": [ + "#NBVAL_SKIP\n", + "model = SimpleEGNN()\n", + "trainer.fit(model, train_dataloaders=train_loader, val_dataloaders=valid_loader)" + ] + }, + { + "cell_type": "code", + "execution_count": 57, + "metadata": {}, + "outputs": [ + { + "name": "stderr", + "output_type": "stream", + "text": [ + "LOCAL_RANK: 0 - CUDA_VISIBLE_DEVICES: [0,1]\n" + ] + }, + { + "name": "stdout", + "output_type": "stream", + "text": [ + "Testing DataLoader 0: 100%|██████████| 29/29 [00:02<00:00, 14.22it/s]\n" + ] + }, + { + "data": { + "text/html": [ + "
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Use the command `python setup.py upload`. """ + import codecs +import contextlib import io import os import re @@ -87,7 +89,7 @@ def read_requirements(*parts): } # Add all requires all_requires = [] -for k, v in EXTRA_REQUIRES.items(): +for v in EXTRA_REQUIRES.values(): all_requires.extend(v) EXTRA_REQUIRES["all"] = set(all_requires) @@ -113,12 +115,9 @@ def finalize_options(self): def run(self): """Publish package to PyPI.""" - try: + with contextlib.suppress(OSError): self.status("Removing previous builds…") rmtree(os.path.join(HERE, "dist")) - except OSError: - pass - self.status("Building Source and Wheel (universal) distribution…") os.system( "{0} setup.py sdist bdist_wheel --universal".format(sys.executable) @@ -136,7 +135,7 @@ def run(self): setup( name="graphein", - version="1.4.0", + version="1.5.0rc1", # versioneer.get_version(), # cmdclass=versioneer.get_cmdclass(), description="Protein & Interactomic Graph Construction for Machine Learning", diff --git a/tests/molecule/test_data/short_test.smi b/tests/molecule/test_data/short_test.smi new file mode 100644 index 00000000..ffba078b --- /dev/null +++ b/tests/molecule/test_data/short_test.smi @@ -0,0 +1 @@ +CC(=O)OC1=CC=CC=C1C(=O)O \ No newline at end of file diff --git a/tests/molecule/test_rdkit_utils.py b/tests/molecule/test_rdkit_utils.py new file mode 100644 index 00000000..087d2b59 --- /dev/null +++ b/tests/molecule/test_rdkit_utils.py @@ -0,0 +1,75 @@ +"""Tests for graphein.molecule.rdkit_utils""" + +from pathlib import Path + +import numpy as np +import rdkit + +import graphein.molecule as gm +import graphein.molecule.utils as u + +TEST_GRAPH = gm.construct_graph( + smiles="CC1=C(C2=C(CCC(O2)(C)COC3=CC=C(C=C3)CC4C(=O)NC(=O)S4)C(=C1O)C)C", + generate_conformer=True, +) +TEST_MOL_GRAPH = gm.construct_graph( + path=str(Path(__file__).parent / "test_data/short_test.mol2") +) + + +def test_get_center(): + center = u.get_center(TEST_MOL_GRAPH) + assert isinstance( + center, np.ndarray + ), f"Center is not a numpy array ({type(center)}" + assert center.shape == (3,), f"Center has wrong shape ({center.shape})" + np.testing.assert_allclose( + np.array([-0.21303333, 0.06743333, 0.0818]), center + ) + + +def test_get_shape_moments(): + moments = u.get_shape_moments(TEST_MOL_GRAPH) + assert isinstance( + moments, tuple + ), f"Moment is not a tuple ({type(moments)})" + assert isinstance( + moments[0], float + ), f"Moment is not a float ({type(moments[0])})" + assert isinstance( + moments[1], float + ), f"Moment is not a float ({type(moments[1])})" + assert moments == ( + 0.12940962096031391, + 0.8705903790396854, + ), f"Moments are not correct ({moments})" + + +def test_count_fragment(): + count = u.count_fragments(TEST_GRAPH) + assert isinstance(count, int), f"Count is not an int ({type(count)})" + assert count == 1, f"Count is not 1 ({count})" + + +def test_get_max_ring_size(): + size = u.get_max_ring_size(TEST_GRAPH) + assert isinstance(size, int), f"Max ring size is not an int ({type(size)})" + assert size == 6, f"Max ring size is not 6 ({size})" + + +def test_get_morgan_fp(): + fp = u.get_morgan_fp(TEST_GRAPH) + assert isinstance( + fp, rdkit.DataStructs.cDataStructs.ExplicitBitVect + ), f"fp is not a BitVect ({type(fp)})" + + +def test_get_morgan_fp_np(): + fp = u.get_morgan_fp_np(TEST_GRAPH) + assert isinstance(fp, np.ndarray), f"fp is not a numpy array ({type(fp)})" + + +def test_get_qed_score(): + qed = u.get_qed_score(TEST_GRAPH) + assert isinstance(qed, float), f"QED is not a float ({type(qed)})" + np.testing.assert_almost_equal(qed, 0.7166041254699328) diff --git a/tests/molecule/test_zinc.py b/tests/molecule/test_zinc.py new file mode 100644 index 00000000..8f2ad276 --- /dev/null +++ b/tests/molecule/test_zinc.py @@ -0,0 +1,47 @@ +import pytest + +import graphein.molecule as gm + +TEST_SMILE = "CCC[S@](=O)c1ccc2[nH]/c(=N\\C(=O)OC)[nH]c2c1" + + +@pytest.mark.skip("Sometimes returns None. Need to check impl to handle this.") +def test_get_smiles_from_zinc(): + smiles = gm.get_smiles_from_zinc("ZINC000000000017") + if smiles is None: + test_get_smiles_from_zinc() + assert smiles == "CCC[S@](=O)c1ccc2[nH]/c(=N\\C(=O)OC)[nH]c2c1" + + +@pytest.mark.skip("Sometimes returns None. Need to check impl to handle this.") +def test_get_zinc_id_from_smile(): + assert gm.get_zinc_id_from_smile(TEST_SMILE) == [ + "ZINC000000000017", + "ZINC000004095934", + ] + + +@pytest.mark.skip("Sometimes returns None. Need to check impl to handle this.") +def test_batch_get_smiles_from_zinc(): + smiles = gm.batch_get_smiles_from_zinc( + ["ZINC000000000017", "ZINC000004095934"] + ) + assert smiles == { + "ZINC000000000017": "CCC[S@](=O)c1ccc2[nH]/c(=N\\C(=O)OC)[nH]c2c1", + "ZINC000004095934": "CCC[S@@](=O)c1ccc2[nH]/c(=N\\C(=O)OC)[nH]c2c1", + } + + +@pytest.mark.skip("Sometimes returns None. Need to check impl to handle this.") +def test_batch_get_zinc_id_from_smile(): + assert gm.batch_get_zinc_id_from_smiles( + [ + "CCC[S@](=O)c1ccc2[nH]/c(=N\\C(=O)OC)[nH]c2c1", + "CCC[S@](=O)c1ccc2[nH]/c(=N\\C(=O)OC)[nH]c2c1", + ] + ) == { + "CCC[S@](=O)c1ccc2[nH]/c(=N\\C(=O)OC)[nH]c2c1": [ + "ZINC000000000017", + "ZINC000004095934", + ] + } diff --git a/tests/ppi/test_graphs.py b/tests/ppi/test_graphs.py index 7cb9528b..cf70f581 100644 --- a/tests/ppi/test_graphs.py +++ b/tests/ppi/test_graphs.py @@ -1,4 +1,6 @@ +import bioservices import networkx as nx +import pytest from graphein.ppi.config import PPIGraphConfig from graphein.ppi.edges import add_biogrid_edges, add_string_edges @@ -17,7 +19,19 @@ ] +@pytest.mark.skip("not a test") +def hgnc_available(): + try: + a = bioservices.HGNC() + return True + except TypeError: + return False + + +HGNC_AVAILABLE = hgnc_available() + # Test Graph Construction +@pytest.mark.skipif(not HGNC_AVAILABLE, reason="HGNC not available") def test_construct_graph(): config = PPIGraphConfig() diff --git a/tests/protein/nodes/features/test_geometry.py b/tests/protein/nodes/features/test_geometry.py index a54b76b1..53041d2b 100644 --- a/tests/protein/nodes/features/test_geometry.py +++ b/tests/protein/nodes/features/test_geometry.py @@ -60,9 +60,9 @@ def test_add_beta_carbon_vector(): else: # Check the vector is pointing in the correct direction cb_true = np.array( - raw_pdb[raw_pdb["node_id"] == n][raw_pdb["atom_name"] == "CB"][ - ["x_coord", "y_coord", "z_coord"] - ] + raw_pdb.loc[ + (raw_pdb.node_id == n) & (raw_pdb.atom_name == "CB") + ][["x_coord", "y_coord", "z_coord"]] ).T.squeeze() np.testing.assert_almost_equal( cb_true, d["coords"] + d["c_beta_vector"] diff --git a/tests/protein/test_graphs.py b/tests/protein/test_graphs.py index a3ec382f..2acd3b4f 100644 --- a/tests/protein/test_graphs.py +++ b/tests/protein/test_graphs.py @@ -329,7 +329,7 @@ def test_sequence_features(): def test_insertion_handling(): configs = { "granularity": "CA", - "keep_hets": False, + "keep_hets": [], "insertions": False, "verbose": False, "node_metadata_functions": [meiler_embedding, expasy_protein_scale], diff --git a/tests/protein/test_subgraphs.py b/tests/protein/test_subgraphs.py index b39d3f76..4ebf5997 100644 --- a/tests/protein/test_subgraphs.py +++ b/tests/protein/test_subgraphs.py @@ -11,8 +11,6 @@ import networkx as nx import numpy as np -import pytest -from sklearn import neighbors from graphein.protein.config import DSSPConfig, ProteinGraphConfig from graphein.protein.edges.distance import ( @@ -380,7 +378,3 @@ def test_successful_pickle(): loaded_graph = pickle.load(f) assert nx.is_isomorphic(s_g, loaded_graph) - - -if __name__ == "__main__": - test_extract_subgraph_from_sequence_position() diff --git a/tests/protein/test_utils.py b/tests/protein/test_utils.py index 27e48a80..105d4567 100644 --- a/tests/protein/test_utils.py +++ b/tests/protein/test_utils.py @@ -4,7 +4,11 @@ from pandas.testing import assert_frame_equal from graphein.protein.config import ProteinGraphConfig -from graphein.protein.graphs import construct_graph, read_pdb_to_dataframe +from graphein.protein.graphs import ( + construct_graph, + filter_dataframe, + read_pdb_to_dataframe, +) from graphein.protein.utils import ( download_pdb, save_graph_to_pdb, @@ -16,9 +20,9 @@ def test_save_graph_to_pdb(): g = construct_graph(pdb_code="4hhb") - save_graph_to_pdb(g, "/tmp/test_graph.pdb") + save_graph_to_pdb(g, "/tmp/test_graph.pdb", hetatms=False) - a = read_pdb_to_dataframe("/tmp/test_graph.pdb").df["ATOM"] + a = read_pdb_to_dataframe("/tmp/test_graph.pdb") # Check file exists assert os.path.isfile("/tmp/test_graph.pdb") @@ -26,7 +30,7 @@ def test_save_graph_to_pdb(): # We drop the line_idx columns as these will be renumbered assert_frame_equal( a.drop(["line_idx"], axis=1), - g.graph["pdb_df"].drop(["line_idx"], axis=1), + g.graph["pdb_df"].drop(["line_idx", "node_id"], axis=1), ) h = construct_graph(pdb_path="/tmp/test_graph.pdb") @@ -37,15 +41,15 @@ def test_save_graph_to_pdb(): def test_save_pdb_df_to_pdb(): g = construct_graph(pdb_code="4hhb") - save_pdb_df_to_pdb(g.graph["pdb_df"], "/tmp/test_pdb.pdb") - a = read_pdb_to_dataframe("/tmp/test_pdb.pdb").df["ATOM"] + save_pdb_df_to_pdb(g.graph["pdb_df"], "/tmp/test_pdb.pdb", hetatms=False) + a = read_pdb_to_dataframe("/tmp/test_pdb.pdb") # Check file exists assert os.path.isfile("/tmp/test_graph.pdb") # We drop the line_idx columns as these will be renumbered assert_frame_equal( a.drop(["line_idx"], axis=1), - g.graph["pdb_df"].drop(["line_idx"], axis=1), + g.graph["pdb_df"].drop(["line_idx", "node_id"], axis=1), ) # Now check for raw, unprocessed DF @@ -59,15 +63,17 @@ def test_save_pdb_df_to_pdb(): def test_save_rgroup_df_to_pdb(): g = construct_graph(pdb_code="4hhb") - save_rgroup_df_to_pdb(g, "/tmp/test_rgroup.pdb") - a = read_pdb_to_dataframe("/tmp/test_rgroup.pdb").df["ATOM"] + save_rgroup_df_to_pdb(g, "/tmp/test_rgroup.pdb", hetatms=False) + a = read_pdb_to_dataframe("/tmp/test_rgroup.pdb") # Check file exists assert os.path.isfile("/tmp/test_rgroup.pdb") # We drop the line_idx columns as these will be renumbered assert_frame_equal( a.drop(["line_idx"], axis=1), - g.graph["rgroup_df"].drop(["line_idx"], axis=1), + filter_dataframe( + g.graph["rgroup_df"], "record_name", ["HETATM"], False + ).drop(["line_idx", "node_id"], axis=1), ) diff --git a/tests/rna/test_data/2jyf.pdb b/tests/rna/test_data/2jyf.pdb new file mode 100644 index 00000000..58742534 --- /dev/null +++ b/tests/rna/test_data/2jyf.pdb @@ -0,0 +1,27811 @@ +HEADER RNA/RNA 13-DEC-07 2JYF +TITLE TETRALOOP-RECEPTOR RNA COMPLEX +COMPND MOL_ID: 1; +COMPND 2 MOLECULE: RNA (43-MER); +COMPND 3 CHAIN: A, B; +COMPND 4 ENGINEERED: YES +SOURCE MOL_ID: 1; +SOURCE 2 SYNTHETIC: YES +KEYWDS RNA STRUCTURE, RNA:RNA COMPLEX, TETRALOOP-RECEPTOR, GAAA-TETRALOOP, +KEYWDS 2 RNA GLOBAL STRUCTURE, COMPLEX INTERFACE, RNA-RNA COMPLEX +EXPDTA SOLUTION NMR +NUMMDL 10 +AUTHOR X.ZUO,J.WANG,T.R.FOSTER,C.D.SCHWIETERS,D.M.TIEDE +REVDAT 3 16-MAR-22 2JYF 1 REMARK +REVDAT 2 24-FEB-09 2JYF 1 VERSN +REVDAT 1 07-OCT-08 2JYF 0 +JRNL AUTH X.ZUO,J.WANG,T.R.FOSTER,C.D.SCHWIETERS,D.M.TIEDE, +JRNL AUTH 2 S.E.BUTCHER,Y.WANG +JRNL TITL TETRALOOP-RECEPTOR RNA COMPLEX +JRNL REF TO BE PUBLISHED +JRNL REFN +REMARK 2 +REMARK 2 RESOLUTION. NOT APPLICABLE. +REMARK 3 +REMARK 3 REFINEMENT. +REMARK 3 PROGRAM : X-PLOR NIH NOT RELEASED, X-PLOR NIH NOT RELEASED, +REMARK 3 DEFINE_THE_INTERMOLECULAR_INTERFACE_USING_SAXS_DATA +REMARK 3 AUTHORS : SCHWIETERS, C.D. ET AL. (X-PLOR NIH), SCHWIETERS, +REMARK 3 C.D. ET AL. (X-PLOR NIH), WANG, J. ET AL. (DEFINE_THE_ +REMARK 3 INTERMOLECULAR_INTERFACE_USING_SAXS_DATA) +REMARK 3 +REMARK 3 OTHER REFINEMENT REMARKS: THE STRUCTURES WERE REFINED AGAINST THE +REMARK 3 SAXS DATA AND NMR-DERIVED RESTRAINTS. +REMARK 4 +REMARK 4 2JYF COMPLIES WITH FORMAT V. 3.15, 01-DEC-08 +REMARK 100 +REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 14-DEC-07. +REMARK 100 THE DEPOSITION ID IS D_1000100446. +REMARK 210 +REMARK 210 EXPERIMENTAL DETAILS +REMARK 210 EXPERIMENT TYPE : NMR +REMARK 210 TEMPERATURE (KELVIN) : 298 +REMARK 210 PH : 7.0 +REMARK 210 IONIC STRENGTH : 20 +REMARK 210 PRESSURE : AMBIENT +REMARK 210 SAMPLE CONTENTS : 8 MG/ML (W/V) RNA:RNA COMPLEX, +REMARK 210 95% H2O/5% D2O +REMARK 210 +REMARK 210 NMR EXPERIMENTS CONDUCTED : 3D 1H-13C NOESY +REMARK 210 SPECTROMETER FIELD STRENGTH : 800 MHZ; 750 MHZ +REMARK 210 SPECTROMETER MODEL : DRX; UNITYPLUS +REMARK 210 SPECTROMETER MANUFACTURER : BRUKER; VARIAN +REMARK 210 +REMARK 210 STRUCTURE DETERMINATION. +REMARK 210 SOFTWARE USED : +REMARK 210 DEFINE_THE_INTERMOLECULAR_INTERFACE_USING_SAXS_DATA +REMARK 210 METHOD USED : SIMULATED ANNEALING, TORSION +REMARK 210 ANGLE DYNAMICS +REMARK 210 +REMARK 210 CONFORMERS, NUMBER CALCULATED : 100 +REMARK 210 CONFORMERS, NUMBER SUBMITTED : 10 +REMARK 210 CONFORMERS, SELECTION CRITERIA : STRUCTURES WITH THE LOWEST +REMARK 210 ENERGY +REMARK 210 +REMARK 210 BEST REPRESENTATIVE CONFORMER IN THIS ENSEMBLE : 1 +REMARK 210 +REMARK 210 REMARK: NULL +REMARK 215 +REMARK 215 NMR STUDY +REMARK 215 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM SOLUTION +REMARK 215 NMR DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE THAT +REMARK 215 CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES ON +REMARK 215 THESE RECORDS ARE MEANINGLESS. +REMARK 300 +REMARK 300 BIOMOLECULE: 1 +REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM +REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN +REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON +REMARK 300 BURIED SURFACE AREA. +REMARK 350 +REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN +REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE +REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS +REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND +REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN. +REMARK 350 +REMARK 350 BIOMOLECULE: 1 +REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DIMERIC +REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B +REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 +REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 +REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 +REMARK 500 +REMARK 500 GEOMETRY AND STEREOCHEMISTRY +REMARK 500 SUBTOPIC: CLOSE CONTACTS +REMARK 500 +REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT. +REMARK 500 +REMARK 500 ATM1 RES C SSEQI ATM2 RES C SSEQI DISTANCE +REMARK 500 HO2' U B 68 O4' U B 69 1.40 +REMARK 500 HO2' U A 25 O4' U A 26 1.40 +REMARK 500 HO2' G A 18 O4' G A 19 1.41 +REMARK 500 HO2' G B 61 O4' G B 62 1.41 +REMARK 500 O2' G A 8 H61 A B 65 1.42 +REMARK 500 H61 A A 22 O2' G B 51 1.43 +REMARK 500 OP2 A B 49 H61 A B 80 1.54 +REMARK 500 OP2 A A 6 H61 A A 37 1.54 +REMARK 500 +REMARK 500 REMARK: NULL +REMARK 900 +REMARK 900 RELATED ENTRIES +REMARK 900 RELATED ID: 2JYH RELATED DB: PDB +DBREF 2JYF A 1 43 PDB 2JYF 2JYF 1 43 +DBREF 2JYF B 44 86 PDB 2JYF 2JYF 44 86 +SEQRES 1 A 43 G G G A U A U G G A A G A +SEQRES 2 A 43 A C C G G G G A A A C U U +SEQRES 3 A 43 G G U U C U U C C U A A G +SEQRES 4 A 43 U C C U +SEQRES 1 B 43 G G G A U A U G G A A G A +SEQRES 2 B 43 A C C G G G G A A A C U U +SEQRES 3 B 43 G G U U C U U C C U A A G +SEQRES 4 B 43 U C C U +CRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1 1 +ORIGX1 1.000000 0.000000 0.000000 0.00000 +ORIGX2 0.000000 1.000000 0.000000 0.00000 +ORIGX3 0.000000 0.000000 1.000000 0.00000 +SCALE1 1.000000 0.000000 0.000000 0.00000 +SCALE2 0.000000 1.000000 0.000000 0.00000 +SCALE3 0.000000 0.000000 1.000000 0.00000 +MODEL 1 +ATOM 1 O5' G A 1 6.291 -37.668 9.239 1.00 1.00 O +ATOM 2 C5' G A 1 7.307 -38.206 8.391 1.00 1.00 C +ATOM 3 C4' G A 1 6.703 -38.940 7.196 1.00 1.00 C +ATOM 4 O4' G A 1 6.060 -40.138 7.644 1.00 1.00 O +ATOM 5 C3' G A 1 5.669 -38.116 6.432 1.00 1.00 C +ATOM 6 O3' G A 1 6.251 -37.623 5.221 1.00 1.00 O +ATOM 7 C2' G A 1 4.571 -39.113 6.102 1.00 1.00 C +ATOM 8 O2' G A 1 4.772 -39.710 4.816 1.00 1.00 O +ATOM 9 C1' G A 1 4.695 -40.136 7.215 1.00 1.00 C +ATOM 10 N9 G A 1 3.867 -39.830 8.387 1.00 1.00 N +ATOM 11 C8 G A 1 4.263 -39.358 9.612 1.00 1.00 C +ATOM 12 N7 G A 1 3.283 -39.181 10.453 1.00 1.00 N +ATOM 13 C5 G A 1 2.153 -39.564 9.736 1.00 1.00 C +ATOM 14 C6 G A 1 0.788 -39.586 10.131 1.00 1.00 C +ATOM 15 O6 G A 1 0.302 -39.266 11.214 1.00 1.00 O +ATOM 16 N1 G A 1 -0.032 -40.039 9.107 1.00 1.00 N +ATOM 17 C2 G A 1 0.404 -40.423 7.856 1.00 1.00 C +ATOM 18 N2 G A 1 -0.535 -40.831 7.001 1.00 1.00 N +ATOM 19 N3 G A 1 1.688 -40.402 7.481 1.00 1.00 N +ATOM 20 C4 G A 1 2.502 -39.963 8.470 1.00 1.00 C +ATOM 21 H5' G A 1 7.926 -38.895 8.970 1.00 1.00 H +ATOM 22 H5'' G A 1 7.933 -37.395 8.024 1.00 1.00 H +ATOM 23 H4' G A 1 7.505 -39.216 6.514 1.00 1.00 H +ATOM 24 H3' G A 1 5.285 -37.303 7.049 1.00 1.00 H +ATOM 25 H2' G A 1 3.597 -38.623 6.154 1.00 1.00 H +ATOM 26 HO2' G A 1 5.265 -40.522 4.952 1.00 1.00 H +ATOM 27 H1' G A 1 4.431 -41.123 6.836 1.00 1.00 H +ATOM 28 H8 G A 1 5.304 -39.149 9.861 1.00 1.00 H +ATOM 29 H1 G A 1 -1.019 -40.083 9.314 1.00 1.00 H +ATOM 30 H21 G A 1 -1.506 -40.847 7.284 1.00 1.00 H +ATOM 31 H22 G A 1 -0.276 -41.124 6.071 1.00 1.00 H +ATOM 32 HO5' G A 1 6.343 -36.711 9.177 1.00 1.00 H +ATOM 33 P G A 2 5.748 -36.237 4.575 1.00 1.00 P +ATOM 34 OP1 G A 2 6.449 -36.050 3.285 1.00 1.00 O +ATOM 35 OP2 G A 2 5.826 -35.185 5.613 1.00 1.00 O +ATOM 36 O5' G A 2 4.193 -36.529 4.268 1.00 1.00 O +ATOM 37 C5' G A 2 3.809 -37.548 3.340 1.00 1.00 C +ATOM 38 C4' G A 2 2.294 -37.738 3.308 1.00 1.00 C +ATOM 39 O4' G A 2 1.830 -38.222 4.567 1.00 1.00 O +ATOM 40 C3' G A 2 1.516 -36.463 3.024 1.00 1.00 C +ATOM 41 O3' G A 2 1.296 -36.346 1.613 1.00 1.00 O +ATOM 42 C2' G A 2 0.187 -36.679 3.735 1.00 1.00 C +ATOM 43 O2' G A 2 -0.824 -37.131 2.828 1.00 1.00 O +ATOM 44 C1' G A 2 0.500 -37.736 4.796 1.00 1.00 C +ATOM 45 N9 G A 2 0.413 -37.234 6.177 1.00 1.00 N +ATOM 46 C8 G A 2 1.406 -36.784 7.009 1.00 1.00 C +ATOM 47 N7 G A 2 0.984 -36.417 8.187 1.00 1.00 N +ATOM 48 C5 G A 2 -0.390 -36.639 8.134 1.00 1.00 C +ATOM 49 C6 G A 2 -1.388 -36.424 9.126 1.00 1.00 C +ATOM 50 O6 G A 2 -1.250 -35.988 10.266 1.00 1.00 O +ATOM 51 N1 G A 2 -2.650 -36.778 8.663 1.00 1.00 N +ATOM 52 C2 G A 2 -2.920 -37.277 7.406 1.00 1.00 C +ATOM 53 N2 G A 2 -4.196 -37.559 7.145 1.00 1.00 N +ATOM 54 N3 G A 2 -1.984 -37.479 6.474 1.00 1.00 N +ATOM 55 C4 G A 2 -0.747 -37.139 6.907 1.00 1.00 C +ATOM 56 H5' G A 2 4.281 -38.488 3.623 1.00 1.00 H +ATOM 57 H5'' G A 2 4.151 -37.265 2.345 1.00 1.00 H +ATOM 58 H4' G A 2 2.050 -38.476 2.545 1.00 1.00 H +ATOM 59 H3' G A 2 2.036 -35.591 3.422 1.00 1.00 H +ATOM 60 H2' G A 2 -0.121 -35.752 4.224 1.00 1.00 H +ATOM 61 HO2' G A 2 -1.648 -36.711 3.083 1.00 1.00 H +ATOM 62 H1' G A 2 -0.203 -38.561 4.686 1.00 1.00 H +ATOM 63 H8 G A 2 2.454 -36.737 6.713 1.00 1.00 H +ATOM 64 H1 G A 2 -3.412 -36.653 9.314 1.00 1.00 H +ATOM 65 H21 G A 2 -4.897 -37.406 7.848 1.00 1.00 H +ATOM 66 H22 G A 2 -4.458 -37.927 6.243 1.00 1.00 H +ATOM 67 P G A 3 0.806 -34.956 0.965 1.00 1.00 P +ATOM 68 OP1 G A 3 1.206 -34.939 -0.460 1.00 1.00 O +ATOM 69 OP2 G A 3 1.221 -33.854 1.861 1.00 1.00 O +ATOM 70 O5' G A 3 -0.799 -35.088 1.034 1.00 1.00 O +ATOM 71 C5' G A 3 -1.471 -36.168 0.377 1.00 1.00 C +ATOM 72 C4' G A 3 -2.933 -36.256 0.800 1.00 1.00 C +ATOM 73 O4' G A 3 -3.003 -36.511 2.204 1.00 1.00 O +ATOM 74 C3' G A 3 -3.732 -34.985 0.531 1.00 1.00 C +ATOM 75 O3' G A 3 -4.434 -35.112 -0.711 1.00 1.00 O +ATOM 76 C2' G A 3 -4.723 -34.932 1.683 1.00 1.00 C +ATOM 77 O2' G A 3 -5.959 -35.569 1.343 1.00 1.00 O +ATOM 78 C1' G A 3 -4.002 -35.675 2.802 1.00 1.00 C +ATOM 79 N9 G A 3 -3.325 -34.785 3.759 1.00 1.00 N +ATOM 80 C8 G A 3 -2.091 -34.194 3.664 1.00 1.00 C +ATOM 81 N7 G A 3 -1.771 -33.469 4.699 1.00 1.00 N +ATOM 82 C5 G A 3 -2.872 -33.585 5.543 1.00 1.00 C +ATOM 83 C6 G A 3 -3.101 -33.012 6.825 1.00 1.00 C +ATOM 84 O6 G A 3 -2.362 -32.278 7.477 1.00 1.00 O +ATOM 85 N1 G A 3 -4.341 -33.380 7.332 1.00 1.00 N +ATOM 86 C2 G A 3 -5.247 -34.196 6.690 1.00 1.00 C +ATOM 87 N2 G A 3 -6.388 -34.433 7.336 1.00 1.00 N +ATOM 88 N3 G A 3 -5.033 -34.737 5.486 1.00 1.00 N +ATOM 89 C4 G A 3 -3.829 -34.389 4.975 1.00 1.00 C +ATOM 90 H5' G A 3 -0.972 -37.104 0.629 1.00 1.00 H +ATOM 91 H5'' G A 3 -1.421 -36.017 -0.702 1.00 1.00 H +ATOM 92 H4' G A 3 -3.401 -37.085 0.277 1.00 1.00 H +ATOM 93 H3' G A 3 -3.081 -34.109 0.537 1.00 1.00 H +ATOM 94 H2' G A 3 -4.890 -33.897 1.981 1.00 1.00 H +ATOM 95 HO2' G A 3 -6.654 -35.124 1.835 1.00 1.00 H +ATOM 96 H1' G A 3 -4.713 -36.300 3.346 1.00 1.00 H +ATOM 97 H8 G A 3 -1.438 -34.317 2.801 1.00 1.00 H +ATOM 98 H1 G A 3 -4.576 -33.010 8.242 1.00 1.00 H +ATOM 99 H21 G A 3 -6.550 -34.020 8.250 1.00 1.00 H +ATOM 100 H22 G A 3 -7.093 -35.024 6.917 1.00 1.00 H +ATOM 101 P A A 4 -4.366 -33.940 -1.816 1.00 1.00 P +ATOM 102 OP1 A A 4 -4.666 -34.533 -3.138 1.00 1.00 O +ATOM 103 OP2 A A 4 -3.108 -33.186 -1.616 1.00 1.00 O +ATOM 104 O5' A A 4 -5.597 -32.986 -1.402 1.00 1.00 O +ATOM 105 C5' A A 4 -6.950 -33.409 -1.599 1.00 1.00 C +ATOM 106 C4' A A 4 -7.926 -32.531 -0.823 1.00 1.00 C +ATOM 107 O4' A A 4 -7.697 -32.682 0.576 1.00 1.00 O +ATOM 108 C3' A A 4 -7.806 -31.046 -1.130 1.00 1.00 C +ATOM 109 O3' A A 4 -8.722 -30.688 -2.169 1.00 1.00 O +ATOM 110 C2' A A 4 -8.224 -30.382 0.171 1.00 1.00 C +ATOM 111 O2' A A 4 -9.628 -30.098 0.188 1.00 1.00 O +ATOM 112 C1' A A 4 -7.852 -31.416 1.229 1.00 1.00 C +ATOM 113 N9 A A 4 -6.590 -31.120 1.925 1.00 1.00 N +ATOM 114 C8 A A 4 -5.308 -31.416 1.539 1.00 1.00 C +ATOM 115 N7 A A 4 -4.398 -31.023 2.386 1.00 1.00 N +ATOM 116 C5 A A 4 -5.129 -30.423 3.408 1.00 1.00 C +ATOM 117 C6 A A 4 -4.748 -29.804 4.608 1.00 1.00 C +ATOM 118 N6 A A 4 -3.478 -29.680 4.995 1.00 1.00 N +ATOM 119 N1 A A 4 -5.728 -29.317 5.388 1.00 1.00 N +ATOM 120 C2 A A 4 -6.990 -29.441 4.996 1.00 1.00 C +ATOM 121 N3 A A 4 -7.473 -30.000 3.896 1.00 1.00 N +ATOM 122 C4 A A 4 -6.466 -30.479 3.135 1.00 1.00 C +ATOM 123 H5' A A 4 -7.055 -34.442 -1.263 1.00 1.00 H +ATOM 124 H5'' A A 4 -7.190 -33.355 -2.661 1.00 1.00 H +ATOM 125 H4' A A 4 -8.941 -32.858 -1.042 1.00 1.00 H +ATOM 126 H3' A A 4 -6.780 -30.782 -1.391 1.00 1.00 H +ATOM 127 H2' A A 4 -7.644 -29.468 0.326 1.00 1.00 H +ATOM 128 HO2' A A 4 -9.995 -30.522 0.966 1.00 1.00 H +ATOM 129 H1' A A 4 -8.654 -31.487 1.962 1.00 1.00 H +ATOM 130 H8 A A 4 -5.070 -31.932 0.609 1.00 1.00 H +ATOM 131 H61 A A 4 -3.257 -29.226 5.868 1.00 1.00 H +ATOM 132 H62 A A 4 -2.738 -30.044 4.413 1.00 1.00 H +ATOM 133 H2 A A 4 -7.734 -29.025 5.676 1.00 1.00 H +ATOM 134 P U A 5 -8.409 -29.439 -3.134 1.00 1.00 P +ATOM 135 OP1 U A 5 -9.640 -29.120 -3.891 1.00 1.00 O +ATOM 136 OP2 U A 5 -7.148 -29.716 -3.857 1.00 1.00 O +ATOM 137 O5' U A 5 -8.139 -28.247 -2.087 1.00 1.00 O +ATOM 138 C5' U A 5 -9.209 -27.672 -1.334 1.00 1.00 C +ATOM 139 C4' U A 5 -8.695 -26.624 -0.351 1.00 1.00 C +ATOM 140 O4' U A 5 -7.938 -27.244 0.681 1.00 1.00 O +ATOM 141 C3' U A 5 -7.788 -25.581 -0.979 1.00 1.00 C +ATOM 142 O3' U A 5 -8.584 -24.486 -1.447 1.00 1.00 O +ATOM 143 C2' U A 5 -6.895 -25.138 0.174 1.00 1.00 C +ATOM 144 O2' U A 5 -7.374 -23.929 0.776 1.00 1.00 O +ATOM 145 C1' U A 5 -6.952 -26.316 1.156 1.00 1.00 C +ATOM 146 N1 U A 5 -5.674 -27.051 1.299 1.00 1.00 N +ATOM 147 C2 U A 5 -4.887 -26.752 2.395 1.00 1.00 C +ATOM 148 O2 U A 5 -5.218 -25.910 3.228 1.00 1.00 O +ATOM 149 N3 U A 5 -3.704 -27.460 2.505 1.00 1.00 N +ATOM 150 C4 U A 5 -3.245 -28.426 1.624 1.00 1.00 C +ATOM 151 O4 U A 5 -2.173 -28.993 1.820 1.00 1.00 O +ATOM 152 C5 U A 5 -4.130 -28.672 0.507 1.00 1.00 C +ATOM 153 C6 U A 5 -5.295 -27.992 0.380 1.00 1.00 C +ATOM 154 H5' U A 5 -9.724 -28.459 -0.781 1.00 1.00 H +ATOM 155 H5'' U A 5 -9.913 -27.200 -2.019 1.00 1.00 H +ATOM 156 H4' U A 5 -9.547 -26.121 0.103 1.00 1.00 H +ATOM 157 H3' U A 5 -7.195 -26.016 -1.786 1.00 1.00 H +ATOM 158 H2' U A 5 -5.869 -25.008 -0.186 1.00 1.00 H +ATOM 159 HO2' U A 5 -8.284 -24.081 1.037 1.00 1.00 H +ATOM 160 H1' U A 5 -7.265 -25.945 2.132 1.00 1.00 H +ATOM 161 H3 U A 5 -3.119 -27.254 3.302 1.00 1.00 H +ATOM 162 H5 U A 5 -3.857 -29.415 -0.242 1.00 1.00 H +ATOM 163 H6 U A 5 -5.944 -28.199 -0.471 1.00 1.00 H +ATOM 164 P A A 6 -8.068 -23.544 -2.646 1.00 1.00 P +ATOM 165 OP1 A A 6 -8.416 -24.195 -3.930 1.00 1.00 O +ATOM 166 OP2 A A 6 -6.666 -23.169 -2.365 1.00 1.00 O +ATOM 167 O5' A A 6 -8.985 -22.231 -2.484 1.00 1.00 O +ATOM 168 C5' A A 6 -10.058 -22.208 -1.539 1.00 1.00 C +ATOM 169 C4' A A 6 -9.849 -21.128 -0.481 1.00 1.00 C +ATOM 170 O4' A A 6 -8.532 -21.256 0.066 1.00 1.00 O +ATOM 171 C3' A A 6 -10.001 -19.700 -1.012 1.00 1.00 C +ATOM 172 O3' A A 6 -10.915 -18.982 -0.176 1.00 1.00 O +ATOM 173 C2' A A 6 -8.610 -19.085 -0.892 1.00 1.00 C +ATOM 174 O2' A A 6 -8.677 -17.725 -0.442 1.00 1.00 O +ATOM 175 C1' A A 6 -7.917 -19.970 0.132 1.00 1.00 C +ATOM 176 N9 A A 6 -6.465 -20.147 -0.094 1.00 1.00 N +ATOM 177 C8 A A 6 -5.822 -20.742 -1.149 1.00 1.00 C +ATOM 178 N7 A A 6 -4.522 -20.731 -1.048 1.00 1.00 N +ATOM 179 C5 A A 6 -4.287 -20.080 0.159 1.00 1.00 C +ATOM 180 C6 A A 6 -3.107 -19.746 0.843 1.00 1.00 C +ATOM 181 N6 A A 6 -1.889 -20.040 0.385 1.00 1.00 N +ATOM 182 N1 A A 6 -3.235 -19.101 2.014 1.00 1.00 N +ATOM 183 C2 A A 6 -4.450 -18.813 2.466 1.00 1.00 C +ATOM 184 N3 A A 6 -5.628 -19.073 1.919 1.00 1.00 N +ATOM 185 C4 A A 6 -5.466 -19.720 0.746 1.00 1.00 C +ATOM 186 H5' A A 6 -10.121 -23.178 -1.049 1.00 1.00 H +ATOM 187 H5'' A A 6 -10.993 -22.013 -2.066 1.00 1.00 H +ATOM 188 H4' A A 6 -10.569 -21.280 0.321 1.00 1.00 H +ATOM 189 H3' A A 6 -10.336 -19.703 -2.051 1.00 1.00 H +ATOM 190 H2' A A 6 -8.090 -19.147 -1.852 1.00 1.00 H +ATOM 191 HO2' A A 6 -7.777 -17.425 -0.303 1.00 1.00 H +ATOM 192 H1' A A 6 -8.071 -19.553 1.126 1.00 1.00 H +ATOM 193 H8 A A 6 -6.350 -21.183 -1.997 1.00 1.00 H +ATOM 194 H61 A A 6 -1.074 -19.778 0.918 1.00 1.00 H +ATOM 195 H62 A A 6 -1.781 -20.525 -0.494 1.00 1.00 H +ATOM 196 H2 A A 6 -4.482 -18.288 3.420 1.00 1.00 H +ATOM 197 P U A 7 -11.256 -17.438 -0.473 1.00 1.00 P +ATOM 198 OP1 U A 7 -12.702 -17.228 -0.238 1.00 1.00 O +ATOM 199 OP2 U A 7 -10.661 -17.075 -1.779 1.00 1.00 O +ATOM 200 O5' U A 7 -10.438 -16.669 0.683 1.00 1.00 O +ATOM 201 C5' U A 7 -11.122 -16.134 1.821 1.00 1.00 C +ATOM 202 C4' U A 7 -10.269 -16.219 3.085 1.00 1.00 C +ATOM 203 O4' U A 7 -10.300 -17.560 3.580 1.00 1.00 O +ATOM 204 C3' U A 7 -8.801 -15.836 2.874 1.00 1.00 C +ATOM 205 O3' U A 7 -8.432 -14.794 3.780 1.00 1.00 O +ATOM 206 C2' U A 7 -8.016 -17.092 3.221 1.00 1.00 C +ATOM 207 O2' U A 7 -6.847 -16.786 3.985 1.00 1.00 O +ATOM 208 C1' U A 7 -8.997 -17.914 4.036 1.00 1.00 C +ATOM 209 N1 U A 7 -8.824 -19.376 3.891 1.00 1.00 N +ATOM 210 C2 U A 7 -9.946 -20.169 4.032 1.00 1.00 C +ATOM 211 O2 U A 7 -11.056 -19.695 4.273 1.00 1.00 O +ATOM 212 N3 U A 7 -9.750 -21.530 3.887 1.00 1.00 N +ATOM 213 C4 U A 7 -8.547 -22.158 3.617 1.00 1.00 C +ATOM 214 O4 U A 7 -8.488 -23.382 3.509 1.00 1.00 O +ATOM 215 C5 U A 7 -7.428 -21.253 3.484 1.00 1.00 C +ATOM 216 C6 U A 7 -7.595 -19.916 3.622 1.00 1.00 C +ATOM 217 H5' U A 7 -12.041 -16.695 1.978 1.00 1.00 H +ATOM 218 H5'' U A 7 -11.370 -15.090 1.628 1.00 1.00 H +ATOM 219 H4' U A 7 -10.699 -15.566 3.842 1.00 1.00 H +ATOM 220 H3' U A 7 -8.620 -15.540 1.839 1.00 1.00 H +ATOM 221 H2' U A 7 -7.750 -17.627 2.306 1.00 1.00 H +ATOM 222 HO2' U A 7 -6.700 -17.518 4.587 1.00 1.00 H +ATOM 223 H1' U A 7 -8.903 -17.645 5.087 1.00 1.00 H +ATOM 224 H3 U A 7 -10.562 -22.123 3.989 1.00 1.00 H +ATOM 225 H5 U A 7 -6.437 -21.652 3.270 1.00 1.00 H +ATOM 226 H6 U A 7 -6.733 -19.256 3.517 1.00 1.00 H +ATOM 227 P G A 8 -7.202 -13.819 3.426 1.00 1.00 P +ATOM 228 OP1 G A 8 -6.757 -13.154 4.672 1.00 1.00 O +ATOM 229 OP2 G A 8 -7.585 -13.006 2.251 1.00 1.00 O +ATOM 230 O5' G A 8 -6.052 -14.852 2.970 1.00 1.00 O +ATOM 231 C5' G A 8 -4.949 -15.143 3.837 1.00 1.00 C +ATOM 232 C4' G A 8 -3.616 -14.974 3.119 1.00 1.00 C +ATOM 233 O4' G A 8 -3.319 -16.150 2.363 1.00 1.00 O +ATOM 234 C3' G A 8 -3.595 -13.803 2.154 1.00 1.00 C +ATOM 235 O3' G A 8 -3.008 -12.667 2.793 1.00 1.00 O +ATOM 236 C2' G A 8 -2.709 -14.267 1.011 1.00 1.00 C +ATOM 237 O2' G A 8 -1.373 -13.773 1.151 1.00 1.00 O +ATOM 238 C1' G A 8 -2.751 -15.784 1.096 1.00 1.00 C +ATOM 239 N9 G A 8 -3.573 -16.402 0.042 1.00 1.00 N +ATOM 240 C8 G A 8 -4.850 -16.890 0.138 1.00 1.00 C +ATOM 241 N7 G A 8 -5.314 -17.382 -0.975 1.00 1.00 N +ATOM 242 C5 G A 8 -4.270 -17.212 -1.879 1.00 1.00 C +ATOM 243 C6 G A 8 -4.196 -17.559 -3.257 1.00 1.00 C +ATOM 244 O6 G A 8 -5.055 -18.092 -3.956 1.00 1.00 O +ATOM 245 N1 G A 8 -2.967 -17.217 -3.802 1.00 1.00 N +ATOM 246 C2 G A 8 -1.935 -16.615 -3.115 1.00 1.00 C +ATOM 247 N2 G A 8 -0.828 -16.367 -3.814 1.00 1.00 N +ATOM 248 N3 G A 8 -2.003 -16.285 -1.818 1.00 1.00 N +ATOM 249 C4 G A 8 -3.197 -16.611 -1.267 1.00 1.00 C +ATOM 250 H5' G A 8 -5.036 -16.172 4.192 1.00 1.00 H +ATOM 251 H5'' G A 8 -4.980 -14.466 4.690 1.00 1.00 H +ATOM 252 H4' G A 8 -2.832 -14.834 3.863 1.00 1.00 H +ATOM 253 H3' G A 8 -4.601 -13.580 1.797 1.00 1.00 H +ATOM 254 H2' G A 8 -3.141 -13.947 0.062 1.00 1.00 H +ATOM 255 HO2' G A 8 -1.306 -12.980 0.617 1.00 1.00 H +ATOM 256 H1' G A 8 -1.739 -16.176 1.032 1.00 1.00 H +ATOM 257 H8 G A 8 -5.424 -16.874 1.065 1.00 1.00 H +ATOM 258 H1 G A 8 -2.841 -17.433 -4.782 1.00 1.00 H +ATOM 259 H21 G A 8 -0.782 -16.617 -4.790 1.00 1.00 H +ATOM 260 H22 G A 8 -0.042 -15.930 -3.372 1.00 1.00 H +ATOM 261 P G A 9 -3.071 -11.222 2.094 1.00 1.00 P +ATOM 262 OP1 G A 9 -2.333 -10.260 2.943 1.00 1.00 O +ATOM 263 OP2 G A 9 -4.475 -10.948 1.716 1.00 1.00 O +ATOM 264 O5' G A 9 -2.221 -11.459 0.748 1.00 1.00 O +ATOM 265 C5' G A 9 -2.781 -11.143 -0.528 1.00 1.00 C +ATOM 266 C4' G A 9 -1.728 -11.189 -1.629 1.00 1.00 C +ATOM 267 O4' G A 9 -1.537 -12.538 -2.066 1.00 1.00 O +ATOM 268 C3' G A 9 -2.100 -10.368 -2.853 1.00 1.00 C +ATOM 269 O3' G A 9 -1.518 -9.065 -2.748 1.00 1.00 O +ATOM 270 C2' G A 9 -1.469 -11.130 -4.005 1.00 1.00 C +ATOM 271 O2' G A 9 -0.153 -10.644 -4.292 1.00 1.00 O +ATOM 272 C1' G A 9 -1.433 -12.568 -3.497 1.00 1.00 C +ATOM 273 N9 G A 9 -2.529 -13.405 -4.015 1.00 1.00 N +ATOM 274 C8 G A 9 -3.487 -14.104 -3.325 1.00 1.00 C +ATOM 275 N7 G A 9 -4.316 -14.758 -4.087 1.00 1.00 N +ATOM 276 C5 G A 9 -3.880 -14.476 -5.378 1.00 1.00 C +ATOM 277 C6 G A 9 -4.396 -14.909 -6.631 1.00 1.00 C +ATOM 278 O6 G A 9 -5.359 -15.643 -6.847 1.00 1.00 O +ATOM 279 N1 G A 9 -3.662 -14.393 -7.691 1.00 1.00 N +ATOM 280 C2 G A 9 -2.568 -13.564 -7.566 1.00 1.00 C +ATOM 281 N2 G A 9 -1.992 -13.171 -8.703 1.00 1.00 N +ATOM 282 N3 G A 9 -2.081 -13.154 -6.390 1.00 1.00 N +ATOM 283 C4 G A 9 -2.785 -13.647 -5.344 1.00 1.00 C +ATOM 284 H5' G A 9 -3.209 -10.142 -0.490 1.00 1.00 H +ATOM 285 H5'' G A 9 -3.569 -11.858 -0.758 1.00 1.00 H +ATOM 286 H4' G A 9 -0.786 -10.819 -1.229 1.00 1.00 H +ATOM 287 H3' G A 9 -3.185 -10.313 -2.971 1.00 1.00 H +ATOM 288 H2' G A 9 -2.107 -11.065 -4.888 1.00 1.00 H +ATOM 289 HO2' G A 9 -0.051 -10.645 -5.248 1.00 1.00 H +ATOM 290 H1' G A 9 -0.482 -13.019 -3.776 1.00 1.00 H +ATOM 291 H8 G A 9 -3.546 -14.113 -2.236 1.00 1.00 H +ATOM 292 H1 G A 9 -3.971 -14.659 -8.615 1.00 1.00 H +ATOM 293 H21 G A 9 -2.360 -13.483 -9.591 1.00 1.00 H +ATOM 294 H22 G A 9 -1.185 -12.564 -8.676 1.00 1.00 H +ATOM 295 P A A 10 -2.391 -7.748 -3.062 1.00 1.00 P +ATOM 296 OP1 A A 10 -1.667 -6.573 -2.527 1.00 1.00 O +ATOM 297 OP2 A A 10 -3.786 -8.008 -2.640 1.00 1.00 O +ATOM 298 O5' A A 10 -2.356 -7.674 -4.669 1.00 1.00 O +ATOM 299 C5' A A 10 -1.132 -7.406 -5.359 1.00 1.00 C +ATOM 300 C4' A A 10 -1.266 -7.670 -6.854 1.00 1.00 C +ATOM 301 O4' A A 10 -1.481 -9.055 -7.088 1.00 1.00 O +ATOM 302 C3' A A 10 -2.425 -6.944 -7.514 1.00 1.00 C +ATOM 303 O3' A A 10 -2.004 -5.649 -7.952 1.00 1.00 O +ATOM 304 C2' A A 10 -2.751 -7.824 -8.711 1.00 1.00 C +ATOM 305 O2' A A 10 -2.074 -7.375 -9.892 1.00 1.00 O +ATOM 306 C1' A A 10 -2.264 -9.210 -8.278 1.00 1.00 C +ATOM 307 N9 A A 10 -3.351 -10.155 -7.972 1.00 1.00 N +ATOM 308 C8 A A 10 -3.996 -10.374 -6.781 1.00 1.00 C +ATOM 309 N7 A A 10 -4.914 -11.298 -6.840 1.00 1.00 N +ATOM 310 C5 A A 10 -4.876 -11.721 -8.165 1.00 1.00 C +ATOM 311 C6 A A 10 -5.609 -12.688 -8.874 1.00 1.00 C +ATOM 312 N6 A A 10 -6.563 -13.434 -8.316 1.00 1.00 N +ATOM 313 N1 A A 10 -5.317 -12.851 -10.175 1.00 1.00 N +ATOM 314 C2 A A 10 -4.365 -12.105 -10.724 1.00 1.00 C +ATOM 315 N3 A A 10 -3.611 -11.170 -10.167 1.00 1.00 N +ATOM 316 C4 A A 10 -3.927 -11.029 -8.862 1.00 1.00 C +ATOM 317 H5' A A 10 -0.347 -8.046 -4.954 1.00 1.00 H +ATOM 318 H5'' A A 10 -0.856 -6.364 -5.205 1.00 1.00 H +ATOM 319 H4' A A 10 -0.339 -7.378 -7.347 1.00 1.00 H +ATOM 320 H3' A A 10 -3.278 -6.879 -6.836 1.00 1.00 H +ATOM 321 H2' A A 10 -3.832 -7.846 -8.871 1.00 1.00 H +ATOM 322 HO2' A A 10 -1.357 -7.991 -10.063 1.00 1.00 H +ATOM 323 H1' A A 10 -1.640 -9.632 -9.063 1.00 1.00 H +ATOM 324 H8 A A 10 -3.762 -9.825 -5.868 1.00 1.00 H +ATOM 325 H61 A A 10 -7.064 -14.118 -8.875 1.00 1.00 H +ATOM 326 H62 A A 10 -6.790 -13.317 -7.339 1.00 1.00 H +ATOM 327 H2 A A 10 -4.180 -12.288 -11.783 1.00 1.00 H +ATOM 328 P A A 11 -3.071 -4.453 -8.109 1.00 1.00 P +ATOM 329 OP1 A A 11 -2.344 -3.233 -8.524 1.00 1.00 O +ATOM 330 OP2 A A 11 -3.917 -4.428 -6.893 1.00 1.00 O +ATOM 331 O5' A A 11 -3.977 -4.949 -9.345 1.00 1.00 O +ATOM 332 C5' A A 11 -3.442 -4.997 -10.671 1.00 1.00 C +ATOM 333 C4' A A 11 -4.459 -5.546 -11.667 1.00 1.00 C +ATOM 334 O4' A A 11 -4.713 -6.924 -11.411 1.00 1.00 O +ATOM 335 C3' A A 11 -5.812 -4.854 -11.629 1.00 1.00 C +ATOM 336 O3' A A 11 -5.808 -3.718 -12.504 1.00 1.00 O +ATOM 337 C2' A A 11 -6.753 -5.916 -12.163 1.00 1.00 C +ATOM 338 O2' A A 11 -6.930 -5.806 -13.577 1.00 1.00 O +ATOM 339 C1' A A 11 -6.070 -7.224 -11.774 1.00 1.00 C +ATOM 340 N9 A A 11 -6.719 -7.914 -10.649 1.00 1.00 N +ATOM 341 C8 A A 11 -6.565 -7.712 -9.301 1.00 1.00 C +ATOM 342 N7 A A 11 -7.296 -8.502 -8.563 1.00 1.00 N +ATOM 343 C5 A A 11 -7.983 -9.281 -9.490 1.00 1.00 C +ATOM 344 C6 A A 11 -8.925 -10.314 -9.349 1.00 1.00 C +ATOM 345 N6 A A 11 -9.351 -10.757 -8.165 1.00 1.00 N +ATOM 346 N1 A A 11 -9.405 -10.868 -10.475 1.00 1.00 N +ATOM 347 C2 A A 11 -8.976 -10.423 -11.650 1.00 1.00 C +ATOM 348 N3 A A 11 -8.100 -9.465 -11.911 1.00 1.00 N +ATOM 349 C4 A A 11 -7.637 -8.929 -10.763 1.00 1.00 C +ATOM 350 H5' A A 11 -2.555 -5.634 -10.677 1.00 1.00 H +ATOM 351 H5'' A A 11 -3.158 -3.990 -10.976 1.00 1.00 H +ATOM 352 H4' A A 11 -4.045 -5.457 -12.672 1.00 1.00 H +ATOM 353 H3' A A 11 -6.078 -4.574 -10.608 1.00 1.00 H +ATOM 354 H2' A A 11 -7.708 -5.843 -11.647 1.00 1.00 H +ATOM 355 HO2' A A 11 -7.832 -5.512 -13.729 1.00 1.00 H +ATOM 356 H1' A A 11 -6.061 -7.889 -12.636 1.00 1.00 H +ATOM 357 H8 A A 11 -5.894 -6.960 -8.885 1.00 1.00 H +ATOM 358 H61 A A 11 -10.033 -11.504 -8.119 1.00 1.00 H +ATOM 359 H62 A A 11 -9.000 -10.346 -7.319 1.00 1.00 H +ATOM 360 H2 A A 11 -9.406 -10.916 -12.522 1.00 1.00 H +ATOM 361 P G A 12 -6.843 -2.503 -12.277 1.00 1.00 P +ATOM 362 OP1 G A 12 -6.307 -1.306 -12.964 1.00 1.00 O +ATOM 363 OP2 G A 12 -7.170 -2.441 -10.836 1.00 1.00 O +ATOM 364 O5' G A 12 -8.159 -2.991 -13.073 1.00 1.00 O +ATOM 365 C5' G A 12 -8.266 -2.819 -14.491 1.00 1.00 C +ATOM 366 C4' G A 12 -9.540 -3.459 -15.043 1.00 1.00 C +ATOM 367 O4' G A 12 -9.568 -4.843 -14.704 1.00 1.00 O +ATOM 368 C3' G A 12 -10.834 -2.850 -14.515 1.00 1.00 C +ATOM 369 O3' G A 12 -11.276 -1.818 -15.404 1.00 1.00 O +ATOM 370 C2' G A 12 -11.805 -4.020 -14.543 1.00 1.00 C +ATOM 371 O2' G A 12 -12.492 -4.114 -15.796 1.00 1.00 O +ATOM 372 C1' G A 12 -10.897 -5.216 -14.314 1.00 1.00 C +ATOM 373 N9 G A 12 -10.843 -5.634 -12.912 1.00 1.00 N +ATOM 374 C8 G A 12 -10.070 -5.130 -11.897 1.00 1.00 C +ATOM 375 N7 G A 12 -10.236 -5.735 -10.755 1.00 1.00 N +ATOM 376 C5 G A 12 -11.190 -6.712 -11.028 1.00 1.00 C +ATOM 377 C6 G A 12 -11.773 -7.683 -10.168 1.00 1.00 C +ATOM 378 O6 G A 12 -11.554 -7.873 -8.973 1.00 1.00 O +ATOM 379 N1 G A 12 -12.693 -8.474 -10.842 1.00 1.00 N +ATOM 380 C2 G A 12 -13.016 -8.349 -12.177 1.00 1.00 C +ATOM 381 N2 G A 12 -13.928 -9.199 -12.646 1.00 1.00 N +ATOM 382 N3 G A 12 -12.469 -7.437 -12.987 1.00 1.00 N +ATOM 383 C4 G A 12 -11.567 -6.656 -12.346 1.00 1.00 C +ATOM 384 H5' G A 12 -7.403 -3.279 -14.974 1.00 1.00 H +ATOM 385 H5'' G A 12 -8.274 -1.752 -14.721 1.00 1.00 H +ATOM 386 H4' G A 12 -9.531 -3.374 -16.127 1.00 1.00 H +ATOM 387 H3' G A 12 -10.703 -2.476 -13.497 1.00 1.00 H +ATOM 388 H2' G A 12 -12.513 -3.946 -13.716 1.00 1.00 H +ATOM 389 HO2' G A 12 -13.405 -4.339 -15.603 1.00 1.00 H +ATOM 390 H1' G A 12 -11.233 -6.057 -14.924 1.00 1.00 H +ATOM 391 H8 G A 12 -9.379 -4.298 -12.035 1.00 1.00 H +ATOM 392 H1 G A 12 -13.150 -9.189 -10.295 1.00 1.00 H +ATOM 393 H21 G A 12 -14.343 -9.889 -12.032 1.00 1.00 H +ATOM 394 H22 G A 12 -14.205 -9.158 -13.616 1.00 1.00 H +ATOM 395 P A A 13 -12.147 -0.577 -14.858 1.00 1.00 P +ATOM 396 OP1 A A 13 -12.401 0.339 -15.993 1.00 1.00 O +ATOM 397 OP2 A A 13 -11.503 -0.063 -13.628 1.00 1.00 O +ATOM 398 O5' A A 13 -13.541 -1.271 -14.448 1.00 1.00 O +ATOM 399 C5' A A 13 -14.421 -1.792 -15.450 1.00 1.00 C +ATOM 400 C4' A A 13 -15.572 -2.582 -14.833 1.00 1.00 C +ATOM 401 O4' A A 13 -15.086 -3.761 -14.195 1.00 1.00 O +ATOM 402 C3' A A 13 -16.349 -1.821 -13.773 1.00 1.00 C +ATOM 403 O3' A A 13 -17.397 -1.059 -14.388 1.00 1.00 O +ATOM 404 C2' A A 13 -16.939 -2.931 -12.922 1.00 1.00 C +ATOM 405 O2' A A 13 -18.245 -3.310 -13.355 1.00 1.00 O +ATOM 406 C1' A A 13 -15.936 -4.068 -13.077 1.00 1.00 C +ATOM 407 N9 A A 13 -15.106 -4.272 -11.885 1.00 1.00 N +ATOM 408 C8 A A 13 -13.954 -3.627 -11.508 1.00 1.00 C +ATOM 409 N7 A A 13 -13.444 -4.070 -10.392 1.00 1.00 N +ATOM 410 C5 A A 13 -14.321 -5.079 -10.001 1.00 1.00 C +ATOM 411 C6 A A 13 -14.343 -5.942 -8.894 1.00 1.00 C +ATOM 412 N6 A A 13 -13.415 -5.924 -7.934 1.00 1.00 N +ATOM 413 N1 A A 13 -15.356 -6.823 -8.818 1.00 1.00 N +ATOM 414 C2 A A 13 -16.275 -6.836 -9.775 1.00 1.00 C +ATOM 415 N3 A A 13 -16.365 -6.080 -10.859 1.00 1.00 N +ATOM 416 C4 A A 13 -15.335 -5.208 -10.907 1.00 1.00 C +ATOM 417 H5' A A 13 -13.856 -2.444 -16.119 1.00 1.00 H +ATOM 418 H5'' A A 13 -14.832 -0.962 -16.027 1.00 1.00 H +ATOM 419 H4' A A 13 -16.254 -2.880 -15.628 1.00 1.00 H +ATOM 420 H3' A A 13 -15.683 -1.188 -13.183 1.00 1.00 H +ATOM 421 H2' A A 13 -16.954 -2.615 -11.882 1.00 1.00 H +ATOM 422 HO2' A A 13 -18.755 -3.521 -12.568 1.00 1.00 H +ATOM 423 H1' A A 13 -16.474 -4.991 -13.289 1.00 1.00 H +ATOM 424 H8 A A 13 -13.508 -2.820 -12.088 1.00 1.00 H +ATOM 425 H61 A A 13 -13.482 -6.568 -7.160 1.00 1.00 H +ATOM 426 H62 A A 13 -12.653 -5.267 -7.983 1.00 1.00 H +ATOM 427 H2 A A 13 -17.069 -7.573 -9.651 1.00 1.00 H +ATOM 428 P A A 14 -17.967 0.276 -13.688 1.00 1.00 P +ATOM 429 OP1 A A 14 -18.654 1.081 -14.723 1.00 1.00 O +ATOM 430 OP2 A A 14 -16.877 0.881 -12.891 1.00 1.00 O +ATOM 431 O5' A A 14 -19.083 -0.290 -12.670 1.00 1.00 O +ATOM 432 C5' A A 14 -20.404 -0.608 -13.127 1.00 1.00 C +ATOM 433 C4' A A 14 -21.294 -1.080 -11.980 1.00 1.00 C +ATOM 434 O4' A A 14 -20.796 -2.313 -11.461 1.00 1.00 O +ATOM 435 C3' A A 14 -21.374 -0.108 -10.808 1.00 1.00 C +ATOM 436 O3' A A 14 -22.496 0.767 -10.967 1.00 1.00 O +ATOM 437 C2' A A 14 -21.593 -1.024 -9.619 1.00 1.00 C +ATOM 438 O2' A A 14 -22.982 -1.295 -9.407 1.00 1.00 O +ATOM 439 C1' A A 14 -20.833 -2.276 -10.028 1.00 1.00 C +ATOM 440 N9 A A 14 -19.445 -2.294 -9.556 1.00 1.00 N +ATOM 441 C8 A A 14 -18.351 -1.664 -10.091 1.00 1.00 C +ATOM 442 N7 A A 14 -17.240 -1.900 -9.449 1.00 1.00 N +ATOM 443 C5 A A 14 -17.627 -2.746 -8.414 1.00 1.00 C +ATOM 444 C6 A A 14 -16.912 -3.361 -7.373 1.00 1.00 C +ATOM 445 N6 A A 14 -15.598 -3.207 -7.199 1.00 1.00 N +ATOM 446 N1 A A 14 -17.606 -4.136 -6.523 1.00 1.00 N +ATOM 447 C2 A A 14 -18.913 -4.284 -6.701 1.00 1.00 C +ATOM 448 N3 A A 14 -19.694 -3.763 -7.635 1.00 1.00 N +ATOM 449 C4 A A 14 -18.969 -2.991 -8.473 1.00 1.00 C +ATOM 450 H5' A A 14 -20.344 -1.399 -13.876 1.00 1.00 H +ATOM 451 H5'' A A 14 -20.848 0.278 -13.582 1.00 1.00 H +ATOM 452 H4' A A 14 -22.296 -1.253 -12.364 1.00 1.00 H +ATOM 453 H3' A A 14 -20.441 0.452 -10.701 1.00 1.00 H +ATOM 454 H2' A A 14 -21.139 -0.593 -8.729 1.00 1.00 H +ATOM 455 HO2' A A 14 -23.041 -2.040 -8.806 1.00 1.00 H +ATOM 456 H1' A A 14 -21.347 -3.163 -9.655 1.00 1.00 H +ATOM 457 H8 A A 14 -18.404 -1.023 -10.972 1.00 1.00 H +ATOM 458 H61 A A 14 -15.133 -3.676 -6.430 1.00 1.00 H +ATOM 459 H62 A A 14 -15.071 -2.627 -7.833 1.00 1.00 H +ATOM 460 H2 A A 14 -19.415 -4.925 -5.976 1.00 1.00 H +ATOM 461 P C A 15 -22.517 2.210 -10.249 1.00 1.00 P +ATOM 462 OP1 C A 15 -23.848 2.817 -10.468 1.00 1.00 O +ATOM 463 OP2 C A 15 -21.297 2.946 -10.653 1.00 1.00 O +ATOM 464 O5' C A 15 -22.385 1.835 -8.688 1.00 1.00 O +ATOM 465 C5' C A 15 -23.523 1.389 -7.946 1.00 1.00 C +ATOM 466 C4' C A 15 -23.128 0.866 -6.567 1.00 1.00 C +ATOM 467 O4' C A 15 -22.158 -0.170 -6.687 1.00 1.00 O +ATOM 468 C3' C A 15 -22.504 1.907 -5.653 1.00 1.00 C +ATOM 469 O3' C A 15 -23.524 2.607 -4.928 1.00 1.00 O +ATOM 470 C2' C A 15 -21.672 1.068 -4.693 1.00 1.00 C +ATOM 471 O2' C A 15 -22.396 0.771 -3.495 1.00 1.00 O +ATOM 472 C1' C A 15 -21.368 -0.205 -5.487 1.00 1.00 C +ATOM 473 N1 C A 15 -19.949 -0.337 -5.877 1.00 1.00 N +ATOM 474 C2 C A 15 -19.136 -1.160 -5.114 1.00 1.00 C +ATOM 475 O2 C A 15 -19.603 -1.761 -4.147 1.00 1.00 O +ATOM 476 N3 C A 15 -17.825 -1.279 -5.464 1.00 1.00 N +ATOM 477 C4 C A 15 -17.333 -0.618 -6.521 1.00 1.00 C +ATOM 478 N4 C A 15 -16.045 -0.754 -6.837 1.00 1.00 N +ATOM 479 C5 C A 15 -18.169 0.232 -7.312 1.00 1.00 C +ATOM 480 C6 C A 15 -19.464 0.342 -6.957 1.00 1.00 C +ATOM 481 H5' C A 15 -24.020 0.592 -8.502 1.00 1.00 H +ATOM 482 H5'' C A 15 -24.217 2.221 -7.825 1.00 1.00 H +ATOM 483 H4' C A 15 -24.011 0.453 -6.083 1.00 1.00 H +ATOM 484 H3' C A 15 -21.872 2.595 -6.218 1.00 1.00 H +ATOM 485 H2' C A 15 -20.742 1.589 -4.458 1.00 1.00 H +ATOM 486 HO2' C A 15 -21.953 0.032 -3.072 1.00 1.00 H +ATOM 487 H1' C A 15 -21.659 -1.068 -4.897 1.00 1.00 H +ATOM 488 H41 C A 15 -15.456 -1.350 -6.283 1.00 1.00 H +ATOM 489 H42 C A 15 -15.663 -0.261 -7.630 1.00 1.00 H +ATOM 490 H5 C A 15 -17.772 0.770 -8.173 1.00 1.00 H +ATOM 491 H6 C A 15 -20.130 0.981 -7.538 1.00 1.00 H +ATOM 492 P C A 16 -23.217 4.049 -4.275 1.00 1.00 P +ATOM 493 OP1 C A 16 -24.418 4.483 -3.526 1.00 1.00 O +ATOM 494 OP2 C A 16 -22.647 4.922 -5.325 1.00 1.00 O +ATOM 495 O5' C A 16 -22.053 3.709 -3.212 1.00 1.00 O +ATOM 496 C5' C A 16 -22.336 2.904 -2.066 1.00 1.00 C +ATOM 497 C4' C A 16 -21.071 2.276 -1.478 1.00 1.00 C +ATOM 498 O4' C A 16 -20.335 1.605 -2.498 1.00 1.00 O +ATOM 499 C3' C A 16 -20.099 3.263 -0.848 1.00 1.00 C +ATOM 500 O3' C A 16 -20.403 3.409 0.543 1.00 1.00 O +ATOM 501 C2' C A 16 -18.746 2.579 -0.991 1.00 1.00 C +ATOM 502 O2' C A 16 -18.362 1.921 0.218 1.00 1.00 O +ATOM 503 C1' C A 16 -18.949 1.579 -2.127 1.00 1.00 C +ATOM 504 N1 C A 16 -18.114 1.844 -3.323 1.00 1.00 N +ATOM 505 C2 C A 16 -16.958 1.089 -3.456 1.00 1.00 C +ATOM 506 O2 C A 16 -16.660 0.264 -2.597 1.00 1.00 O +ATOM 507 N3 C A 16 -16.179 1.293 -4.554 1.00 1.00 N +ATOM 508 C4 C A 16 -16.516 2.199 -5.481 1.00 1.00 C +ATOM 509 N4 C A 16 -15.729 2.370 -6.543 1.00 1.00 N +ATOM 510 C5 C A 16 -17.706 2.981 -5.345 1.00 1.00 C +ATOM 511 C6 C A 16 -18.473 2.774 -4.257 1.00 1.00 C +ATOM 512 H5' C A 16 -23.028 2.111 -2.352 1.00 1.00 H +ATOM 513 H5'' C A 16 -22.806 3.527 -1.306 1.00 1.00 H +ATOM 514 H4' C A 16 -21.362 1.544 -0.726 1.00 1.00 H +ATOM 515 H3' C A 16 -20.117 4.221 -1.368 1.00 1.00 H +ATOM 516 H2' C A 16 -17.994 3.320 -1.284 1.00 1.00 H +ATOM 517 HO2' C A 16 -18.494 0.980 0.084 1.00 1.00 H +ATOM 518 H1' C A 16 -18.721 0.581 -1.751 1.00 1.00 H +ATOM 519 H41 C A 16 -14.884 1.821 -6.642 1.00 1.00 H +ATOM 520 H42 C A 16 -15.973 3.052 -7.247 1.00 1.00 H +ATOM 521 H5 C A 16 -17.983 3.720 -6.099 1.00 1.00 H +ATOM 522 H6 C A 16 -19.384 3.354 -4.119 1.00 1.00 H +ATOM 523 P G A 17 -19.657 4.522 1.435 1.00 1.00 P +ATOM 524 OP1 G A 17 -20.531 4.855 2.582 1.00 1.00 O +ATOM 525 OP2 G A 17 -19.186 5.596 0.532 1.00 1.00 O +ATOM 526 O5' G A 17 -18.366 3.734 1.996 1.00 1.00 O +ATOM 527 C5' G A 17 -18.508 2.682 2.959 1.00 1.00 C +ATOM 528 C4' G A 17 -17.151 2.147 3.419 1.00 1.00 C +ATOM 529 O4' G A 17 -16.489 1.493 2.339 1.00 1.00 O +ATOM 530 C3' G A 17 -16.199 3.216 3.925 1.00 1.00 C +ATOM 531 O3' G A 17 -16.359 3.386 5.336 1.00 1.00 O +ATOM 532 C2' G A 17 -14.822 2.647 3.624 1.00 1.00 C +ATOM 533 O2' G A 17 -14.281 1.955 4.752 1.00 1.00 O +ATOM 534 C1' G A 17 -15.072 1.695 2.461 1.00 1.00 C +ATOM 535 N9 G A 17 -14.590 2.211 1.177 1.00 1.00 N +ATOM 536 C8 G A 17 -15.314 2.786 0.164 1.00 1.00 C +ATOM 537 N7 G A 17 -14.595 3.156 -0.858 1.00 1.00 N +ATOM 538 C5 G A 17 -13.297 2.801 -0.500 1.00 1.00 C +ATOM 539 C6 G A 17 -12.080 2.959 -1.218 1.00 1.00 C +ATOM 540 O6 G A 17 -11.908 3.453 -2.331 1.00 1.00 O +ATOM 541 N1 G A 17 -10.997 2.470 -0.500 1.00 1.00 N +ATOM 542 C2 G A 17 -11.072 1.899 0.752 1.00 1.00 C +ATOM 543 N2 G A 17 -9.919 1.491 1.282 1.00 1.00 N +ATOM 544 N3 G A 17 -12.215 1.748 1.430 1.00 1.00 N +ATOM 545 C4 G A 17 -13.284 2.221 0.745 1.00 1.00 C +ATOM 546 H5' G A 17 -19.080 1.867 2.515 1.00 1.00 H +ATOM 547 H5'' G A 17 -19.048 3.064 3.825 1.00 1.00 H +ATOM 548 H4' G A 17 -17.314 1.417 4.210 1.00 1.00 H +ATOM 549 H3' G A 17 -16.353 4.156 3.391 1.00 1.00 H +ATOM 550 H2' G A 17 -14.151 3.451 3.308 1.00 1.00 H +ATOM 551 HO2' G A 17 -13.470 1.532 4.462 1.00 1.00 H +ATOM 552 H1' G A 17 -14.588 0.742 2.666 1.00 1.00 H +ATOM 553 H8 G A 17 -16.394 2.922 0.210 1.00 1.00 H +ATOM 554 H1 G A 17 -10.096 2.548 -0.947 1.00 1.00 H +ATOM 555 H21 G A 17 -9.058 1.606 0.768 1.00 1.00 H +ATOM 556 H22 G A 17 -9.908 1.064 2.197 1.00 1.00 H +ATOM 557 P G A 18 -15.839 4.726 6.062 1.00 1.00 P +ATOM 558 OP1 G A 18 -16.231 4.661 7.487 1.00 1.00 O +ATOM 559 OP2 G A 18 -16.241 5.885 5.237 1.00 1.00 O +ATOM 560 O5' G A 18 -14.236 4.575 5.973 1.00 1.00 O +ATOM 561 C5' G A 18 -13.565 3.505 6.646 1.00 1.00 C +ATOM 562 C4' G A 18 -12.054 3.558 6.427 1.00 1.00 C +ATOM 563 O4' G A 18 -11.749 3.342 5.053 1.00 1.00 O +ATOM 564 C3' G A 18 -11.415 4.884 6.804 1.00 1.00 C +ATOM 565 O3' G A 18 -11.000 4.845 8.174 1.00 1.00 O +ATOM 566 C2' G A 18 -10.201 4.974 5.893 1.00 1.00 C +ATOM 567 O2' G A 18 -9.018 4.527 6.559 1.00 1.00 O +ATOM 568 C1' G A 18 -10.556 4.064 4.717 1.00 1.00 C +ATOM 569 N9 G A 18 -10.816 4.789 3.463 1.00 1.00 N +ATOM 570 C8 G A 18 -11.982 5.368 3.033 1.00 1.00 C +ATOM 571 N7 G A 18 -11.889 5.942 1.867 1.00 1.00 N +ATOM 572 C5 G A 18 -10.565 5.730 1.493 1.00 1.00 C +ATOM 573 C6 G A 18 -9.877 6.130 0.313 1.00 1.00 C +ATOM 574 O6 G A 18 -10.312 6.762 -0.648 1.00 1.00 O +ATOM 575 N1 G A 18 -8.552 5.715 0.331 1.00 1.00 N +ATOM 576 C2 G A 18 -7.960 5.005 1.353 1.00 1.00 C +ATOM 577 N2 G A 18 -6.674 4.696 1.189 1.00 1.00 N +ATOM 578 N3 G A 18 -8.605 4.628 2.463 1.00 1.00 N +ATOM 579 C4 G A 18 -9.900 5.025 2.463 1.00 1.00 C +ATOM 580 H5' G A 18 -13.944 2.554 6.272 1.00 1.00 H +ATOM 581 H5'' G A 18 -13.769 3.574 7.715 1.00 1.00 H +ATOM 582 H4' G A 18 -11.588 2.765 7.009 1.00 1.00 H +ATOM 583 H3' G A 18 -12.102 5.712 6.619 1.00 1.00 H +ATOM 584 H2' G A 18 -10.082 6.002 5.542 1.00 1.00 H +ATOM 585 HO2' G A 18 -8.313 5.139 6.326 1.00 1.00 H +ATOM 586 H1' G A 18 -9.743 3.356 4.555 1.00 1.00 H +ATOM 587 H8 G A 18 -12.903 5.348 3.614 1.00 1.00 H +ATOM 588 H1 G A 18 -7.998 5.963 -0.476 1.00 1.00 H +ATOM 589 H21 G A 18 -6.190 4.981 0.351 1.00 1.00 H +ATOM 590 H22 G A 18 -6.185 4.176 1.903 1.00 1.00 H +ATOM 591 P G A 19 -10.521 6.188 8.924 1.00 1.00 P +ATOM 592 OP1 G A 19 -10.482 5.918 10.378 1.00 1.00 O +ATOM 593 OP2 G A 19 -11.324 7.318 8.405 1.00 1.00 O +ATOM 594 O5' G A 19 -9.005 6.365 8.401 1.00 1.00 O +ATOM 595 C5' G A 19 -7.993 5.415 8.757 1.00 1.00 C +ATOM 596 C4' G A 19 -6.711 5.623 7.952 1.00 1.00 C +ATOM 597 O4' G A 19 -7.012 5.617 6.558 1.00 1.00 O +ATOM 598 C3' G A 19 -5.998 6.933 8.249 1.00 1.00 C +ATOM 599 O3' G A 19 -4.991 6.709 9.244 1.00 1.00 O +ATOM 600 C2' G A 19 -5.349 7.305 6.925 1.00 1.00 C +ATOM 601 O2' G A 19 -3.991 6.854 6.861 1.00 1.00 O +ATOM 602 C1' G A 19 -6.220 6.603 5.885 1.00 1.00 C +ATOM 603 N9 G A 19 -7.148 7.502 5.179 1.00 1.00 N +ATOM 604 C8 G A 19 -8.383 7.947 5.573 1.00 1.00 C +ATOM 605 N7 G A 19 -8.958 8.742 4.713 1.00 1.00 N +ATOM 606 C5 G A 19 -8.038 8.833 3.673 1.00 1.00 C +ATOM 607 C6 G A 19 -8.112 9.560 2.453 1.00 1.00 C +ATOM 608 O6 G A 19 -9.022 10.280 2.048 1.00 1.00 O +ATOM 609 N1 G A 19 -6.971 9.379 1.682 1.00 1.00 N +ATOM 610 C2 G A 19 -5.893 8.597 2.037 1.00 1.00 C +ATOM 611 N2 G A 19 -4.888 8.548 1.163 1.00 1.00 N +ATOM 612 N3 G A 19 -5.821 7.912 3.183 1.00 1.00 N +ATOM 613 C4 G A 19 -6.926 8.076 3.949 1.00 1.00 C +ATOM 614 H5' G A 19 -8.369 4.409 8.574 1.00 1.00 H +ATOM 615 H5'' G A 19 -7.766 5.521 9.819 1.00 1.00 H +ATOM 616 H4' G A 19 -6.031 4.799 8.159 1.00 1.00 H +ATOM 617 H3' G A 19 -6.708 7.699 8.567 1.00 1.00 H +ATOM 618 H2' G A 19 -5.402 8.388 6.779 1.00 1.00 H +ATOM 619 HO2' G A 19 -4.007 5.894 6.873 1.00 1.00 H +ATOM 620 H1' G A 19 -5.581 6.111 5.150 1.00 1.00 H +ATOM 621 H8 G A 19 -8.844 7.663 6.519 1.00 1.00 H +ATOM 622 H1 G A 19 -6.951 9.868 0.797 1.00 1.00 H +ATOM 623 H21 G A 19 -4.944 9.065 0.300 1.00 1.00 H +ATOM 624 H22 G A 19 -4.070 7.992 1.366 1.00 1.00 H +ATOM 625 P G A 20 -4.659 7.835 10.346 1.00 1.00 P +ATOM 626 OP1 G A 20 -3.776 7.232 11.370 1.00 1.00 O +ATOM 627 OP2 G A 20 -5.931 8.475 10.753 1.00 1.00 O +ATOM 628 O5' G A 20 -3.802 8.906 9.508 1.00 1.00 O +ATOM 629 C5' G A 20 -3.857 10.295 9.841 1.00 1.00 C +ATOM 630 C4' G A 20 -3.324 11.168 8.707 1.00 1.00 C +ATOM 631 O4' G A 20 -3.728 10.630 7.445 1.00 1.00 O +ATOM 632 C3' G A 20 -3.801 12.613 8.764 1.00 1.00 C +ATOM 633 O3' G A 20 -2.800 13.415 9.397 1.00 1.00 O +ATOM 634 C2' G A 20 -3.937 13.006 7.301 1.00 1.00 C +ATOM 635 O2' G A 20 -2.727 13.593 6.806 1.00 1.00 O +ATOM 636 C1' G A 20 -4.237 11.678 6.610 1.00 1.00 C +ATOM 637 N9 G A 20 -5.672 11.412 6.414 1.00 1.00 N +ATOM 638 C8 G A 20 -6.555 10.825 7.282 1.00 1.00 C +ATOM 639 N7 G A 20 -7.772 10.740 6.824 1.00 1.00 N +ATOM 640 C5 G A 20 -7.694 11.310 5.557 1.00 1.00 C +ATOM 641 C6 G A 20 -8.711 11.497 4.581 1.00 1.00 C +ATOM 642 O6 G A 20 -9.899 11.191 4.650 1.00 1.00 O +ATOM 643 N1 G A 20 -8.215 12.109 3.439 1.00 1.00 N +ATOM 644 C2 G A 20 -6.905 12.497 3.254 1.00 1.00 C +ATOM 645 N2 G A 20 -6.623 13.070 2.084 1.00 1.00 N +ATOM 646 N3 G A 20 -5.945 12.323 4.171 1.00 1.00 N +ATOM 647 C4 G A 20 -6.411 11.725 5.294 1.00 1.00 C +ATOM 648 H5' G A 20 -3.256 10.468 10.734 1.00 1.00 H +ATOM 649 H5'' G A 20 -4.889 10.569 10.051 1.00 1.00 H +ATOM 650 H4' G A 20 -2.236 11.158 8.747 1.00 1.00 H +ATOM 651 H3' G A 20 -4.761 12.691 9.278 1.00 1.00 H +ATOM 652 H2' G A 20 -4.781 13.691 7.175 1.00 1.00 H +ATOM 653 HO2' G A 20 -2.680 14.488 7.153 1.00 1.00 H +ATOM 654 H1' G A 20 -3.734 11.649 5.642 1.00 1.00 H +ATOM 655 H8 G A 20 -6.266 10.461 8.267 1.00 1.00 H +ATOM 656 H1 G A 20 -8.881 12.275 2.699 1.00 1.00 H +ATOM 657 H21 G A 20 -7.350 13.198 1.394 1.00 1.00 H +ATOM 658 H22 G A 20 -5.682 13.374 1.887 1.00 1.00 H +ATOM 659 P A A 21 -3.119 14.183 10.774 1.00 1.00 P +ATOM 660 OP1 A A 21 -1.841 14.668 11.343 1.00 1.00 O +ATOM 661 OP2 A A 21 -4.011 13.329 11.589 1.00 1.00 O +ATOM 662 O5' A A 21 -3.962 15.461 10.265 1.00 1.00 O +ATOM 663 C5' A A 21 -4.871 16.139 11.139 1.00 1.00 C +ATOM 664 C4' A A 21 -5.352 17.461 10.535 1.00 1.00 C +ATOM 665 O4' A A 21 -4.269 18.399 10.498 1.00 1.00 O +ATOM 666 C3' A A 21 -5.896 17.328 9.115 1.00 1.00 C +ATOM 667 O3' A A 21 -7.327 17.360 9.147 1.00 1.00 O +ATOM 668 C2' A A 21 -5.372 18.564 8.392 1.00 1.00 C +ATOM 669 O2' A A 21 -6.326 19.632 8.418 1.00 1.00 O +ATOM 670 C1' A A 21 -4.117 18.925 9.173 1.00 1.00 C +ATOM 671 N9 A A 21 -2.883 18.349 8.613 1.00 1.00 N +ATOM 672 C8 A A 21 -2.293 17.155 8.935 1.00 1.00 C +ATOM 673 N7 A A 21 -1.201 16.909 8.264 1.00 1.00 N +ATOM 674 C5 A A 21 -1.060 18.021 7.439 1.00 1.00 C +ATOM 675 C6 A A 21 -0.099 18.376 6.478 1.00 1.00 C +ATOM 676 N6 A A 21 0.948 17.609 6.174 1.00 1.00 N +ATOM 677 N1 A A 21 -0.264 19.551 5.846 1.00 1.00 N +ATOM 678 C2 A A 21 -1.309 20.309 6.153 1.00 1.00 C +ATOM 679 N3 A A 21 -2.275 20.087 7.030 1.00 1.00 N +ATOM 680 C4 A A 21 -2.082 18.903 7.647 1.00 1.00 C +ATOM 681 H5' A A 21 -4.368 16.344 12.084 1.00 1.00 H +ATOM 682 H5'' A A 21 -5.732 15.497 11.326 1.00 1.00 H +ATOM 683 H4' A A 21 -6.134 17.867 11.172 1.00 1.00 H +ATOM 684 H3' A A 21 -5.529 16.415 8.642 1.00 1.00 H +ATOM 685 H2' A A 21 -5.106 18.309 7.365 1.00 1.00 H +ATOM 686 HO2' A A 21 -7.116 19.299 8.848 1.00 1.00 H +ATOM 687 H1' A A 21 -4.019 20.009 9.220 1.00 1.00 H +ATOM 688 H8 A A 21 -2.698 16.474 9.683 1.00 1.00 H +ATOM 689 H61 A A 21 1.610 17.913 5.475 1.00 1.00 H +ATOM 690 H62 A A 21 1.080 16.726 6.644 1.00 1.00 H +ATOM 691 H2 A A 21 -1.381 21.247 5.602 1.00 1.00 H +ATOM 692 P A A 22 -8.183 16.706 7.950 1.00 1.00 P +ATOM 693 OP1 A A 22 -9.599 16.636 8.375 1.00 1.00 O +ATOM 694 OP2 A A 22 -7.487 15.480 7.497 1.00 1.00 O +ATOM 695 O5' A A 22 -8.061 17.812 6.789 1.00 1.00 O +ATOM 696 C5' A A 22 -7.760 17.425 5.448 1.00 1.00 C +ATOM 697 C4' A A 22 -6.937 18.490 4.733 1.00 1.00 C +ATOM 698 O4' A A 22 -5.705 18.678 5.429 1.00 1.00 O +ATOM 699 C3' A A 22 -6.595 18.141 3.287 1.00 1.00 C +ATOM 700 O3' A A 22 -7.513 18.791 2.402 1.00 1.00 O +ATOM 701 C2' A A 22 -5.205 18.720 3.091 1.00 1.00 C +ATOM 702 O2' A A 22 -5.261 20.045 2.553 1.00 1.00 O +ATOM 703 C1' A A 22 -4.619 18.712 4.497 1.00 1.00 C +ATOM 704 N9 A A 22 -3.762 17.548 4.771 1.00 1.00 N +ATOM 705 C8 A A 22 -3.994 16.490 5.611 1.00 1.00 C +ATOM 706 N7 A A 22 -3.020 15.621 5.649 1.00 1.00 N +ATOM 707 C5 A A 22 -2.076 16.143 4.769 1.00 1.00 C +ATOM 708 C6 A A 22 -0.810 15.693 4.360 1.00 1.00 C +ATOM 709 N6 A A 22 -0.257 14.565 4.807 1.00 1.00 N +ATOM 710 N1 A A 22 -0.142 16.453 3.475 1.00 1.00 N +ATOM 711 C2 A A 22 -0.699 17.574 3.034 1.00 1.00 C +ATOM 712 N3 A A 22 -1.875 18.101 3.341 1.00 1.00 N +ATOM 713 C4 A A 22 -2.521 17.316 4.229 1.00 1.00 C +ATOM 714 H5' A A 22 -8.690 17.267 4.903 1.00 1.00 H +ATOM 715 H5'' A A 22 -7.194 16.493 5.468 1.00 1.00 H +ATOM 716 H4' A A 22 -7.487 19.428 4.750 1.00 1.00 H +ATOM 717 H3' A A 22 -6.592 17.060 3.136 1.00 1.00 H +ATOM 718 H2' A A 22 -4.618 18.066 2.444 1.00 1.00 H +ATOM 719 HO2' A A 22 -6.027 20.082 1.974 1.00 1.00 H +ATOM 720 H1' A A 22 -4.040 19.621 4.657 1.00 1.00 H +ATOM 721 H8 A A 22 -4.909 16.382 6.196 1.00 1.00 H +ATOM 722 H61 A A 22 0.659 14.286 4.480 1.00 1.00 H +ATOM 723 H62 A A 22 -0.752 13.990 5.471 1.00 1.00 H +ATOM 724 H2 A A 22 -0.105 18.142 2.318 1.00 1.00 H +ATOM 725 P A A 23 -8.107 18.015 1.122 1.00 1.00 P +ATOM 726 OP1 A A 23 -9.054 18.919 0.430 1.00 1.00 O +ATOM 727 OP2 A A 23 -8.558 16.675 1.562 1.00 1.00 O +ATOM 728 O5' A A 23 -6.814 17.827 0.181 1.00 1.00 O +ATOM 729 C5' A A 23 -6.414 18.857 -0.728 1.00 1.00 C +ATOM 730 C4' A A 23 -5.040 18.569 -1.327 1.00 1.00 C +ATOM 731 O4' A A 23 -4.088 18.395 -0.274 1.00 1.00 O +ATOM 732 C3' A A 23 -4.996 17.314 -2.191 1.00 1.00 C +ATOM 733 O3' A A 23 -5.131 17.670 -3.570 1.00 1.00 O +ATOM 734 C2' A A 23 -3.605 16.752 -1.941 1.00 1.00 C +ATOM 735 O2' A A 23 -2.662 17.243 -2.901 1.00 1.00 O +ATOM 736 C1' A A 23 -3.278 17.242 -0.536 1.00 1.00 C +ATOM 737 N9 A A 23 -3.560 16.251 0.518 1.00 1.00 N +ATOM 738 C8 A A 23 -4.766 15.911 1.075 1.00 1.00 C +ATOM 739 N7 A A 23 -4.684 14.974 1.981 1.00 1.00 N +ATOM 740 C5 A A 23 -3.325 14.675 2.028 1.00 1.00 C +ATOM 741 C6 A A 23 -2.580 13.759 2.790 1.00 1.00 C +ATOM 742 N6 A A 23 -3.123 12.940 3.690 1.00 1.00 N +ATOM 743 N1 A A 23 -1.252 13.724 2.583 1.00 1.00 N +ATOM 744 C2 A A 23 -0.715 14.539 1.683 1.00 1.00 C +ATOM 745 N3 A A 23 -1.306 15.436 0.909 1.00 1.00 N +ATOM 746 C4 A A 23 -2.635 15.449 1.139 1.00 1.00 C +ATOM 747 H5' A A 23 -6.378 19.810 -0.198 1.00 1.00 H +ATOM 748 H5'' A A 23 -7.146 18.926 -1.533 1.00 1.00 H +ATOM 749 H4' A A 23 -4.734 19.423 -1.929 1.00 1.00 H +ATOM 750 H3' A A 23 -5.765 16.603 -1.885 1.00 1.00 H +ATOM 751 H2' A A 23 -3.638 15.660 -1.953 1.00 1.00 H +ATOM 752 HO2' A A 23 -2.170 17.952 -2.479 1.00 1.00 H +ATOM 753 H1' A A 23 -2.228 17.523 -0.488 1.00 1.00 H +ATOM 754 H8 A A 23 -5.707 16.380 0.788 1.00 1.00 H +ATOM 755 H61 A A 23 -2.538 12.302 4.209 1.00 1.00 H +ATOM 756 H62 A A 23 -4.125 12.956 3.854 1.00 1.00 H +ATOM 757 H2 A A 23 0.365 14.457 1.566 1.00 1.00 H +ATOM 758 P C A 24 -6.105 16.832 -4.540 1.00 1.00 P +ATOM 759 OP1 C A 24 -5.994 17.393 -5.905 1.00 1.00 O +ATOM 760 OP2 C A 24 -7.431 16.732 -3.890 1.00 1.00 O +ATOM 761 O5' C A 24 -5.433 15.369 -4.543 1.00 1.00 O +ATOM 762 C5' C A 24 -4.066 15.195 -4.929 1.00 1.00 C +ATOM 763 C4' C A 24 -3.507 13.867 -4.428 1.00 1.00 C +ATOM 764 O4' C A 24 -3.686 13.774 -3.015 1.00 1.00 O +ATOM 765 C3' C A 24 -4.172 12.639 -5.030 1.00 1.00 C +ATOM 766 O3' C A 24 -3.451 12.213 -6.191 1.00 1.00 O +ATOM 767 C2' C A 24 -4.046 11.596 -3.936 1.00 1.00 C +ATOM 768 O2' C A 24 -2.849 10.827 -4.076 1.00 1.00 O +ATOM 769 C1' C A 24 -4.021 12.424 -2.660 1.00 1.00 C +ATOM 770 N1 C A 24 -5.316 12.457 -1.959 1.00 1.00 N +ATOM 771 C2 C A 24 -5.517 11.545 -0.934 1.00 1.00 C +ATOM 772 O2 C A 24 -4.633 10.741 -0.644 1.00 1.00 O +ATOM 773 N3 C A 24 -6.707 11.568 -0.274 1.00 1.00 N +ATOM 774 C4 C A 24 -7.661 12.450 -0.605 1.00 1.00 C +ATOM 775 N4 C A 24 -8.816 12.447 0.062 1.00 1.00 N +ATOM 776 C5 C A 24 -7.456 13.393 -1.661 1.00 1.00 C +ATOM 777 C6 C A 24 -6.275 13.361 -2.308 1.00 1.00 C +ATOM 778 H5' C A 24 -3.472 16.010 -4.514 1.00 1.00 H +ATOM 779 H5'' C A 24 -3.998 15.222 -6.017 1.00 1.00 H +ATOM 780 H4' C A 24 -2.441 13.832 -4.641 1.00 1.00 H +ATOM 781 H3' C A 24 -5.222 12.837 -5.262 1.00 1.00 H +ATOM 782 H2' C A 24 -4.925 10.948 -3.937 1.00 1.00 H +ATOM 783 HO2' C A 24 -2.798 10.239 -3.318 1.00 1.00 H +ATOM 784 H1' C A 24 -3.260 12.030 -1.991 1.00 1.00 H +ATOM 785 H41 C A 24 -8.964 11.783 0.809 1.00 1.00 H +ATOM 786 H42 C A 24 -9.540 13.108 -0.180 1.00 1.00 H +ATOM 787 H5 C A 24 -8.230 14.111 -1.934 1.00 1.00 H +ATOM 788 H6 C A 24 -6.085 14.065 -3.119 1.00 1.00 H +ATOM 789 P U A 25 -4.127 11.198 -7.245 1.00 1.00 P +ATOM 790 OP1 U A 25 -3.202 11.037 -8.388 1.00 1.00 O +ATOM 791 OP2 U A 25 -5.521 11.635 -7.479 1.00 1.00 O +ATOM 792 O5' U A 25 -4.163 9.810 -6.427 1.00 1.00 O +ATOM 793 C5' U A 25 -2.948 9.180 -6.008 1.00 1.00 C +ATOM 794 C4' U A 25 -3.206 8.094 -4.968 1.00 1.00 C +ATOM 795 O4' U A 25 -3.999 8.617 -3.906 1.00 1.00 O +ATOM 796 C3' U A 25 -3.954 6.882 -5.498 1.00 1.00 C +ATOM 797 O3' U A 25 -3.022 5.912 -5.988 1.00 1.00 O +ATOM 798 C2' U A 25 -4.665 6.342 -4.269 1.00 1.00 C +ATOM 799 O2' U A 25 -3.897 5.317 -3.634 1.00 1.00 O +ATOM 800 C1' U A 25 -4.817 7.566 -3.366 1.00 1.00 C +ATOM 801 N1 U A 25 -6.200 8.077 -3.290 1.00 1.00 N +ATOM 802 C2 U A 25 -7.006 7.624 -2.261 1.00 1.00 C +ATOM 803 O2 U A 25 -6.605 6.821 -1.422 1.00 1.00 O +ATOM 804 N3 U A 25 -8.295 8.127 -2.233 1.00 1.00 N +ATOM 805 C4 U A 25 -8.839 9.032 -3.129 1.00 1.00 C +ATOM 806 O4 U A 25 -10.001 9.413 -3.007 1.00 1.00 O +ATOM 807 C5 U A 25 -7.926 9.451 -4.169 1.00 1.00 C +ATOM 808 C6 U A 25 -6.659 8.972 -4.218 1.00 1.00 C +ATOM 809 H5' U A 25 -2.286 9.933 -5.580 1.00 1.00 H +ATOM 810 H5'' U A 25 -2.462 8.731 -6.875 1.00 1.00 H +ATOM 811 H4' U A 25 -2.254 7.770 -4.554 1.00 1.00 H +ATOM 812 H3' U A 25 -4.671 7.173 -6.269 1.00 1.00 H +ATOM 813 H2' U A 25 -5.648 5.967 -4.551 1.00 1.00 H +ATOM 814 HO2' U A 25 -4.505 4.615 -3.391 1.00 1.00 H +ATOM 815 H1' U A 25 -4.468 7.320 -2.364 1.00 1.00 H +ATOM 816 H3 U A 25 -8.894 7.805 -1.487 1.00 1.00 H +ATOM 817 H5 U A 25 -8.261 10.161 -4.924 1.00 1.00 H +ATOM 818 H6 U A 25 -5.993 9.304 -5.015 1.00 1.00 H +ATOM 819 P U A 26 -3.499 4.761 -7.009 1.00 1.00 P +ATOM 820 OP1 U A 26 -2.307 4.243 -7.716 1.00 1.00 O +ATOM 821 OP2 U A 26 -4.649 5.278 -7.784 1.00 1.00 O +ATOM 822 O5' U A 26 -4.036 3.607 -6.022 1.00 1.00 O +ATOM 823 C5' U A 26 -3.167 3.010 -5.055 1.00 1.00 C +ATOM 824 C4' U A 26 -3.954 2.309 -3.951 1.00 1.00 C +ATOM 825 O4' U A 26 -4.798 3.248 -3.288 1.00 1.00 O +ATOM 826 C3' U A 26 -4.867 1.198 -4.437 1.00 1.00 C +ATOM 827 O3' U A 26 -4.148 -0.047 -4.476 1.00 1.00 O +ATOM 828 C2' U A 26 -5.958 1.159 -3.370 1.00 1.00 C +ATOM 829 O2' U A 26 -5.648 0.234 -2.328 1.00 1.00 O +ATOM 830 C1' U A 26 -5.988 2.584 -2.832 1.00 1.00 C +ATOM 831 N1 U A 26 -7.152 3.361 -3.306 1.00 1.00 N +ATOM 832 C2 U A 26 -8.257 3.457 -2.480 1.00 1.00 C +ATOM 833 O2 U A 26 -8.294 2.922 -1.375 1.00 1.00 O +ATOM 834 N3 U A 26 -9.322 4.188 -2.974 1.00 1.00 N +ATOM 835 C4 U A 26 -9.378 4.822 -4.204 1.00 1.00 C +ATOM 836 O4 U A 26 -10.380 5.449 -4.540 1.00 1.00 O +ATOM 837 C5 U A 26 -8.181 4.670 -4.999 1.00 1.00 C +ATOM 838 C6 U A 26 -7.124 3.959 -4.536 1.00 1.00 C +ATOM 839 H5' U A 26 -2.542 3.785 -4.609 1.00 1.00 H +ATOM 840 H5'' U A 26 -2.529 2.279 -5.551 1.00 1.00 H +ATOM 841 H4' U A 26 -3.255 1.903 -3.223 1.00 1.00 H +ATOM 842 H3' U A 26 -5.288 1.445 -5.413 1.00 1.00 H +ATOM 843 H2' U A 26 -6.919 0.925 -3.832 1.00 1.00 H +ATOM 844 HO2' U A 26 -5.409 0.748 -1.555 1.00 1.00 H +ATOM 845 H1' U A 26 -5.988 2.558 -1.741 1.00 1.00 H +ATOM 846 H3 U A 26 -10.137 4.266 -2.381 1.00 1.00 H +ATOM 847 H5 U A 26 -8.129 5.129 -5.985 1.00 1.00 H +ATOM 848 H6 U A 26 -6.233 3.861 -5.157 1.00 1.00 H +ATOM 849 P G A 27 -4.694 -1.301 -5.339 1.00 1.00 P +ATOM 850 OP1 G A 27 -3.666 -2.366 -5.322 1.00 1.00 O +ATOM 851 OP2 G A 27 -5.208 -0.791 -6.629 1.00 1.00 O +ATOM 852 O5' G A 27 -5.944 -1.795 -4.455 1.00 1.00 O +ATOM 853 C5' G A 27 -5.750 -2.120 -3.080 1.00 1.00 C +ATOM 854 C4' G A 27 -7.051 -2.030 -2.288 1.00 1.00 C +ATOM 855 O4' G A 27 -7.694 -0.790 -2.592 1.00 1.00 O +ATOM 856 C3' G A 27 -8.070 -3.116 -2.597 1.00 1.00 C +ATOM 857 O3' G A 27 -7.901 -4.192 -1.666 1.00 1.00 O +ATOM 858 C2' G A 27 -9.410 -2.444 -2.340 1.00 1.00 C +ATOM 859 O2' G A 27 -9.924 -2.784 -1.049 1.00 1.00 O +ATOM 860 C1' G A 27 -9.108 -0.953 -2.455 1.00 1.00 C +ATOM 861 N9 G A 27 -9.805 -0.299 -3.577 1.00 1.00 N +ATOM 862 C8 G A 27 -9.361 0.027 -4.834 1.00 1.00 C +ATOM 863 N7 G A 27 -10.248 0.644 -5.564 1.00 1.00 N +ATOM 864 C5 G A 27 -11.361 0.734 -4.734 1.00 1.00 C +ATOM 865 C6 G A 27 -12.639 1.309 -4.979 1.00 1.00 C +ATOM 866 O6 G A 27 -13.043 1.865 -5.997 1.00 1.00 O +ATOM 867 N1 G A 27 -13.473 1.185 -3.876 1.00 1.00 N +ATOM 868 C2 G A 27 -13.124 0.585 -2.684 1.00 1.00 C +ATOM 869 N2 G A 27 -14.064 0.556 -1.741 1.00 1.00 N +ATOM 870 N3 G A 27 -11.924 0.047 -2.451 1.00 1.00 N +ATOM 871 C4 G A 27 -11.097 0.158 -3.516 1.00 1.00 C +ATOM 872 H5' G A 27 -5.021 -1.430 -2.650 1.00 1.00 H +ATOM 873 H5'' G A 27 -5.363 -3.136 -3.005 1.00 1.00 H +ATOM 874 H4' G A 27 -6.820 -2.047 -1.225 1.00 1.00 H +ATOM 875 H3' G A 27 -7.986 -3.457 -3.629 1.00 1.00 H +ATOM 876 H2' G A 27 -10.116 -2.733 -3.125 1.00 1.00 H +ATOM 877 HO2' G A 27 -10.196 -1.967 -0.624 1.00 1.00 H +ATOM 878 H1' G A 27 -9.419 -0.462 -1.536 1.00 1.00 H +ATOM 879 H8 G A 27 -8.359 -0.215 -5.193 1.00 1.00 H +ATOM 880 H1 G A 27 -14.400 1.571 -3.973 1.00 1.00 H +ATOM 881 H21 G A 27 -14.971 0.962 -1.918 1.00 1.00 H +ATOM 882 H22 G A 27 -13.868 0.128 -0.847 1.00 1.00 H +ATOM 883 P G A 28 -8.705 -5.574 -1.842 1.00 1.00 P +ATOM 884 OP1 G A 28 -7.916 -6.649 -1.201 1.00 1.00 O +ATOM 885 OP2 G A 28 -9.105 -5.700 -3.260 1.00 1.00 O +ATOM 886 O5' G A 28 -10.035 -5.338 -0.959 1.00 1.00 O +ATOM 887 C5' G A 28 -9.977 -5.319 0.474 1.00 1.00 C +ATOM 888 C4' G A 28 -11.367 -5.192 1.091 1.00 1.00 C +ATOM 889 O4' G A 28 -11.910 -3.897 0.807 1.00 1.00 O +ATOM 890 C3' G A 28 -12.365 -6.225 0.576 1.00 1.00 C +ATOM 891 O3' G A 28 -12.455 -7.317 1.498 1.00 1.00 O +ATOM 892 C2' G A 28 -13.676 -5.464 0.536 1.00 1.00 C +ATOM 893 O2' G A 28 -14.381 -5.557 1.780 1.00 1.00 O +ATOM 894 C1' G A 28 -13.224 -4.042 0.253 1.00 1.00 C +ATOM 895 N9 G A 28 -13.124 -3.737 -1.178 1.00 1.00 N +ATOM 896 C8 G A 28 -12.042 -3.899 -2.003 1.00 1.00 C +ATOM 897 N7 G A 28 -12.261 -3.547 -3.239 1.00 1.00 N +ATOM 898 C5 G A 28 -13.585 -3.117 -3.235 1.00 1.00 C +ATOM 899 C6 G A 28 -14.381 -2.617 -4.301 1.00 1.00 C +ATOM 900 O6 G A 28 -14.067 -2.455 -5.479 1.00 1.00 O +ATOM 901 N1 G A 28 -15.662 -2.298 -3.873 1.00 1.00 N +ATOM 902 C2 G A 28 -16.124 -2.442 -2.583 1.00 1.00 C +ATOM 903 N2 G A 28 -17.388 -2.081 -2.367 1.00 1.00 N +ATOM 904 N3 G A 28 -15.377 -2.912 -1.577 1.00 1.00 N +ATOM 905 C4 G A 28 -14.123 -3.229 -1.977 1.00 1.00 C +ATOM 906 H5' G A 28 -9.370 -4.475 0.796 1.00 1.00 H +ATOM 907 H5'' G A 28 -9.514 -6.244 0.826 1.00 1.00 H +ATOM 908 H4' G A 28 -11.281 -5.294 2.170 1.00 1.00 H +ATOM 909 H3' G A 28 -12.087 -6.568 -0.423 1.00 1.00 H +ATOM 910 H2' G A 28 -14.290 -5.822 -0.286 1.00 1.00 H +ATOM 911 HO2' G A 28 -13.818 -5.171 2.455 1.00 1.00 H +ATOM 912 H1' G A 28 -13.903 -3.333 0.726 1.00 1.00 H +ATOM 913 H8 G A 28 -11.083 -4.285 -1.657 1.00 1.00 H +ATOM 914 H1 G A 28 -16.288 -1.935 -4.577 1.00 1.00 H +ATOM 915 H21 G A 28 -17.946 -1.727 -3.122 1.00 1.00 H +ATOM 916 H22 G A 28 -17.784 -2.163 -1.441 1.00 1.00 H +ATOM 917 P U A 29 -12.676 -8.824 0.968 1.00 1.00 P +ATOM 918 OP1 U A 29 -12.624 -9.734 2.133 1.00 1.00 O +ATOM 919 OP2 U A 29 -11.768 -9.046 -0.181 1.00 1.00 O +ATOM 920 O5' U A 29 -14.187 -8.800 0.415 1.00 1.00 O +ATOM 921 C5' U A 29 -15.296 -8.893 1.315 1.00 1.00 C +ATOM 922 C4' U A 29 -16.624 -8.728 0.585 1.00 1.00 C +ATOM 923 O4' U A 29 -16.683 -7.447 -0.027 1.00 1.00 O +ATOM 924 C3' U A 29 -16.861 -9.733 -0.528 1.00 1.00 C +ATOM 925 O3' U A 29 -17.473 -10.915 0.005 1.00 1.00 O +ATOM 926 C2' U A 29 -17.831 -9.000 -1.446 1.00 1.00 C +ATOM 927 O2' U A 29 -19.191 -9.288 -1.108 1.00 1.00 O +ATOM 928 C1' U A 29 -17.496 -7.522 -1.210 1.00 1.00 C +ATOM 929 N1 U A 29 -16.714 -6.906 -2.302 1.00 1.00 N +ATOM 930 C2 U A 29 -17.395 -6.221 -3.291 1.00 1.00 C +ATOM 931 O2 U A 29 -18.619 -6.109 -3.285 1.00 1.00 O +ATOM 932 N3 U A 29 -16.616 -5.668 -4.291 1.00 1.00 N +ATOM 933 C4 U A 29 -15.237 -5.739 -4.387 1.00 1.00 C +ATOM 934 O4 U A 29 -14.645 -5.207 -5.324 1.00 1.00 O +ATOM 935 C5 U A 29 -14.609 -6.473 -3.311 1.00 1.00 C +ATOM 936 C6 U A 29 -15.351 -7.025 -2.320 1.00 1.00 C +ATOM 937 H5' U A 29 -15.208 -8.115 2.075 1.00 1.00 H +ATOM 938 H5'' U A 29 -15.279 -9.868 1.803 1.00 1.00 H +ATOM 939 H4' U A 29 -17.434 -8.796 1.306 1.00 1.00 H +ATOM 940 H3' U A 29 -15.928 -9.966 -1.049 1.00 1.00 H +ATOM 941 H2' U A 29 -17.629 -9.263 -2.483 1.00 1.00 H +ATOM 942 HO2' U A 29 -19.702 -9.247 -1.920 1.00 1.00 H +ATOM 943 H1' U A 29 -18.413 -6.957 -1.057 1.00 1.00 H +ATOM 944 H3 U A 29 -17.099 -5.164 -5.021 1.00 1.00 H +ATOM 945 H5 U A 29 -13.526 -6.586 -3.297 1.00 1.00 H +ATOM 946 H6 U A 29 -14.852 -7.573 -1.521 1.00 1.00 H +ATOM 947 P U A 30 -16.992 -12.377 -0.477 1.00 1.00 P +ATOM 948 OP1 U A 30 -17.741 -13.391 0.299 1.00 1.00 O +ATOM 949 OP2 U A 30 -15.512 -12.400 -0.481 1.00 1.00 O +ATOM 950 O5' U A 30 -17.500 -12.435 -2.003 1.00 1.00 O +ATOM 951 C5' U A 30 -18.862 -12.750 -2.305 1.00 1.00 C +ATOM 952 C4' U A 30 -19.176 -12.524 -3.781 1.00 1.00 C +ATOM 953 O4' U A 30 -18.989 -11.153 -4.114 1.00 1.00 O +ATOM 954 C3' U A 30 -18.298 -13.305 -4.744 1.00 1.00 C +ATOM 955 O3' U A 30 -18.855 -14.599 -4.994 1.00 1.00 O +ATOM 956 C2' U A 30 -18.348 -12.470 -6.010 1.00 1.00 C +ATOM 957 O2' U A 30 -19.396 -12.903 -6.884 1.00 1.00 O +ATOM 958 C1' U A 30 -18.595 -11.054 -5.491 1.00 1.00 C +ATOM 959 N1 U A 30 -17.399 -10.190 -5.547 1.00 1.00 N +ATOM 960 C2 U A 30 -17.255 -9.356 -6.639 1.00 1.00 C +ATOM 961 O2 U A 30 -18.082 -9.321 -7.549 1.00 1.00 O +ATOM 962 N3 U A 30 -16.125 -8.560 -6.651 1.00 1.00 N +ATOM 963 C4 U A 30 -15.138 -8.526 -5.679 1.00 1.00 C +ATOM 964 O4 U A 30 -14.172 -7.775 -5.793 1.00 1.00 O +ATOM 965 C5 U A 30 -15.371 -9.429 -4.575 1.00 1.00 C +ATOM 966 C6 U A 30 -16.471 -10.220 -4.541 1.00 1.00 C +ATOM 967 H5' U A 30 -19.517 -12.120 -1.700 1.00 1.00 H +ATOM 968 H5'' U A 30 -19.048 -13.794 -2.060 1.00 1.00 H +ATOM 969 H4' U A 30 -20.218 -12.778 -3.962 1.00 1.00 H +ATOM 970 H3' U A 30 -17.274 -13.377 -4.365 1.00 1.00 H +ATOM 971 H2' U A 30 -17.386 -12.511 -6.515 1.00 1.00 H +ATOM 972 HO2' U A 30 -20.007 -13.423 -6.358 1.00 1.00 H +ATOM 973 H1' U A 30 -19.401 -10.597 -6.062 1.00 1.00 H +ATOM 974 H3 U A 30 -16.006 -7.944 -7.444 1.00 1.00 H +ATOM 975 H5 U A 30 -14.649 -9.477 -3.759 1.00 1.00 H +ATOM 976 H6 U A 30 -16.621 -10.891 -3.695 1.00 1.00 H +ATOM 977 P C A 31 -17.937 -15.769 -5.614 1.00 1.00 P +ATOM 978 OP1 C A 31 -18.763 -16.989 -5.741 1.00 1.00 O +ATOM 979 OP2 C A 31 -16.668 -15.812 -4.856 1.00 1.00 O +ATOM 980 O5' C A 31 -17.620 -15.225 -7.098 1.00 1.00 O +ATOM 981 C5' C A 31 -18.636 -15.221 -8.106 1.00 1.00 C +ATOM 982 C4' C A 31 -18.231 -14.381 -9.315 1.00 1.00 C +ATOM 983 O4' C A 31 -17.831 -13.083 -8.900 1.00 1.00 O +ATOM 984 C3' C A 31 -17.057 -14.931 -10.103 1.00 1.00 C +ATOM 985 O3' C A 31 -17.517 -15.893 -11.058 1.00 1.00 O +ATOM 986 C2' C A 31 -16.533 -13.690 -10.820 1.00 1.00 C +ATOM 987 O2' C A 31 -17.104 -13.556 -12.129 1.00 1.00 O +ATOM 988 C1' C A 31 -16.950 -12.540 -9.896 1.00 1.00 C +ATOM 989 N1 C A 31 -15.816 -11.902 -9.195 1.00 1.00 N +ATOM 990 C2 C A 31 -15.299 -10.735 -9.734 1.00 1.00 C +ATOM 991 O2 C A 31 -15.778 -10.270 -10.766 1.00 1.00 O +ATOM 992 N3 C A 31 -14.261 -10.131 -9.094 1.00 1.00 N +ATOM 993 C4 C A 31 -13.750 -10.652 -7.969 1.00 1.00 C +ATOM 994 N4 C A 31 -12.733 -10.035 -7.368 1.00 1.00 N +ATOM 995 C5 C A 31 -14.281 -11.856 -7.408 1.00 1.00 C +ATOM 996 C6 C A 31 -15.309 -12.446 -8.049 1.00 1.00 C +ATOM 997 H5' C A 31 -19.558 -14.817 -7.685 1.00 1.00 H +ATOM 998 H5'' C A 31 -18.815 -16.245 -8.434 1.00 1.00 H +ATOM 999 H4' C A 31 -19.090 -14.280 -9.975 1.00 1.00 H +ATOM 1000 H3' C A 31 -16.299 -15.351 -9.438 1.00 1.00 H +ATOM 1001 H2' C A 31 -15.451 -13.732 -10.880 1.00 1.00 H +ATOM 1002 HO2' C A 31 -17.962 -13.142 -12.026 1.00 1.00 H +ATOM 1003 H1' C A 31 -17.486 -11.787 -10.472 1.00 1.00 H +ATOM 1004 H41 C A 31 -12.356 -9.180 -7.765 1.00 1.00 H +ATOM 1005 H42 C A 31 -12.339 -10.416 -6.520 1.00 1.00 H +ATOM 1006 H5 C A 31 -13.868 -12.282 -6.493 1.00 1.00 H +ATOM 1007 H6 C A 31 -15.739 -13.364 -7.649 1.00 1.00 H +ATOM 1008 P U A 32 -16.798 -17.331 -11.180 1.00 1.00 P +ATOM 1009 OP1 U A 32 -17.763 -18.284 -11.772 1.00 1.00 O +ATOM 1010 OP2 U A 32 -16.163 -17.640 -9.880 1.00 1.00 O +ATOM 1011 O5' U A 32 -15.631 -17.058 -12.255 1.00 1.00 O +ATOM 1012 C5' U A 32 -15.930 -16.437 -13.506 1.00 1.00 C +ATOM 1013 C4' U A 32 -14.898 -15.372 -13.870 1.00 1.00 C +ATOM 1014 O4' U A 32 -14.764 -14.422 -12.819 1.00 1.00 O +ATOM 1015 C3' U A 32 -13.499 -15.907 -14.115 1.00 1.00 C +ATOM 1016 O3' U A 32 -13.373 -16.296 -15.489 1.00 1.00 O +ATOM 1017 C2' U A 32 -12.612 -14.701 -13.834 1.00 1.00 C +ATOM 1018 O2' U A 32 -12.249 -14.019 -15.039 1.00 1.00 O +ATOM 1019 C1' U A 32 -13.468 -13.817 -12.924 1.00 1.00 C +ATOM 1020 N1 U A 32 -12.908 -13.625 -11.564 1.00 1.00 N +ATOM 1021 C2 U A 32 -12.152 -12.488 -11.352 1.00 1.00 C +ATOM 1022 O2 U A 32 -11.936 -11.672 -12.246 1.00 1.00 O +ATOM 1023 N3 U A 32 -11.649 -12.322 -10.075 1.00 1.00 N +ATOM 1024 C4 U A 32 -11.834 -13.183 -9.006 1.00 1.00 C +ATOM 1025 O4 U A 32 -11.340 -12.934 -7.908 1.00 1.00 O +ATOM 1026 C5 U A 32 -12.636 -14.346 -9.318 1.00 1.00 C +ATOM 1027 C6 U A 32 -13.139 -14.529 -10.562 1.00 1.00 C +ATOM 1028 H5' U A 32 -16.917 -15.975 -13.449 1.00 1.00 H +ATOM 1029 H5'' U A 32 -15.938 -17.197 -14.286 1.00 1.00 H +ATOM 1030 H4' U A 32 -15.238 -14.848 -14.765 1.00 1.00 H +ATOM 1031 H3' U A 32 -13.269 -16.731 -13.439 1.00 1.00 H +ATOM 1032 H2' U A 32 -11.720 -15.024 -13.289 1.00 1.00 H +ATOM 1033 HO2' U A 32 -12.524 -13.104 -14.941 1.00 1.00 H +ATOM 1034 H1' U A 32 -13.583 -12.844 -13.401 1.00 1.00 H +ATOM 1035 H3 U A 32 -11.095 -11.494 -9.906 1.00 1.00 H +ATOM 1036 H5 U A 32 -12.837 -15.084 -8.542 1.00 1.00 H +ATOM 1037 H6 U A 32 -13.740 -15.415 -10.770 1.00 1.00 H +ATOM 1038 P U A 33 -12.223 -17.323 -15.958 1.00 1.00 P +ATOM 1039 OP1 U A 33 -12.528 -17.756 -17.341 1.00 1.00 O +ATOM 1040 OP2 U A 33 -12.044 -18.333 -14.894 1.00 1.00 O +ATOM 1041 O5' U A 33 -10.906 -16.397 -16.003 1.00 1.00 O +ATOM 1042 C5' U A 33 -10.630 -15.573 -17.142 1.00 1.00 C +ATOM 1043 C4' U A 33 -9.270 -14.887 -17.028 1.00 1.00 C +ATOM 1044 O4' U A 33 -9.281 -13.981 -15.932 1.00 1.00 O +ATOM 1045 C3' U A 33 -8.107 -15.839 -16.797 1.00 1.00 C +ATOM 1046 O3' U A 33 -7.518 -16.196 -18.049 1.00 1.00 O +ATOM 1047 C2' U A 33 -7.118 -15.017 -15.984 1.00 1.00 C +ATOM 1048 O2' U A 33 -6.114 -14.433 -16.822 1.00 1.00 O +ATOM 1049 C1' U A 33 -7.982 -13.944 -15.324 1.00 1.00 C +ATOM 1050 N1 U A 33 -8.176 -14.153 -13.878 1.00 1.00 N +ATOM 1051 C2 U A 33 -7.353 -13.465 -13.006 1.00 1.00 C +ATOM 1052 O2 U A 33 -6.478 -12.696 -13.399 1.00 1.00 O +ATOM 1053 N3 U A 33 -7.570 -13.694 -11.659 1.00 1.00 N +ATOM 1054 C4 U A 33 -8.525 -14.537 -11.117 1.00 1.00 C +ATOM 1055 O4 U A 33 -8.630 -14.664 -9.899 1.00 1.00 O +ATOM 1056 C5 U A 33 -9.340 -15.213 -12.101 1.00 1.00 C +ATOM 1057 C6 U A 33 -9.146 -15.005 -13.426 1.00 1.00 C +ATOM 1058 H5' U A 33 -11.405 -14.810 -17.228 1.00 1.00 H +ATOM 1059 H5'' U A 33 -10.641 -16.191 -18.039 1.00 1.00 H +ATOM 1060 H4' U A 33 -9.085 -14.319 -17.938 1.00 1.00 H +ATOM 1061 H3' U A 33 -8.430 -16.722 -16.242 1.00 1.00 H +ATOM 1062 H2' U A 33 -6.659 -15.645 -15.216 1.00 1.00 H +ATOM 1063 HO2' U A 33 -5.992 -13.527 -16.531 1.00 1.00 H +ATOM 1064 H1' U A 33 -7.535 -12.964 -15.493 1.00 1.00 H +ATOM 1065 H3 U A 33 -6.976 -13.199 -11.009 1.00 1.00 H +ATOM 1066 H5 U A 33 -10.121 -15.899 -11.774 1.00 1.00 H +ATOM 1067 H6 U A 33 -9.775 -15.528 -14.147 1.00 1.00 H +ATOM 1068 P C A 34 -6.448 -17.395 -18.129 1.00 1.00 P +ATOM 1069 OP1 C A 34 -6.015 -17.538 -19.537 1.00 1.00 O +ATOM 1070 OP2 C A 34 -7.001 -18.560 -17.403 1.00 1.00 O +ATOM 1071 O5' C A 34 -5.211 -16.810 -17.277 1.00 1.00 O +ATOM 1072 C5' C A 34 -4.569 -17.609 -16.280 1.00 1.00 C +ATOM 1073 C4' C A 34 -3.491 -16.822 -15.536 1.00 1.00 C +ATOM 1074 O4' C A 34 -4.100 -15.839 -14.700 1.00 1.00 O +ATOM 1075 C3' C A 34 -2.611 -17.679 -14.640 1.00 1.00 C +ATOM 1076 O3' C A 34 -1.430 -18.060 -15.352 1.00 1.00 O +ATOM 1077 C2' C A 34 -2.242 -16.758 -13.488 1.00 1.00 C +ATOM 1078 O2' C A 34 -0.960 -16.155 -13.696 1.00 1.00 O +ATOM 1079 C1' C A 34 -3.354 -15.709 -13.482 1.00 1.00 C +ATOM 1080 N1 C A 34 -4.308 -15.856 -12.368 1.00 1.00 N +ATOM 1081 C2 C A 34 -3.973 -15.280 -11.154 1.00 1.00 C +ATOM 1082 O2 C A 34 -2.910 -14.673 -11.033 1.00 1.00 O +ATOM 1083 N3 C A 34 -4.845 -15.404 -10.117 1.00 1.00 N +ATOM 1084 C4 C A 34 -6.001 -16.066 -10.267 1.00 1.00 C +ATOM 1085 N4 C A 34 -6.833 -16.170 -9.231 1.00 1.00 N +ATOM 1086 C5 C A 34 -6.351 -16.664 -11.518 1.00 1.00 C +ATOM 1087 C6 C A 34 -5.479 -16.535 -12.538 1.00 1.00 C +ATOM 1088 H5' C A 34 -4.112 -18.475 -16.758 1.00 1.00 H +ATOM 1089 H5'' C A 34 -5.318 -17.952 -15.564 1.00 1.00 H +ATOM 1090 H4' C A 34 -2.864 -16.313 -16.265 1.00 1.00 H +ATOM 1091 H3' C A 34 -3.157 -18.554 -14.280 1.00 1.00 H +ATOM 1092 H2' C A 34 -2.255 -17.317 -12.548 1.00 1.00 H +ATOM 1093 HO2' C A 34 -0.366 -16.507 -13.028 1.00 1.00 H +ATOM 1094 H1' C A 34 -2.907 -14.717 -13.439 1.00 1.00 H +ATOM 1095 H41 C A 34 -6.594 -15.752 -8.350 1.00 1.00 H +ATOM 1096 H42 C A 34 -7.706 -16.666 -9.333 1.00 1.00 H +ATOM 1097 H5 C A 34 -7.289 -17.202 -11.644 1.00 1.00 H +ATOM 1098 H6 C A 34 -5.714 -16.976 -13.507 1.00 1.00 H +ATOM 1099 P C A 35 -0.523 -19.284 -14.831 1.00 1.00 P +ATOM 1100 OP1 C A 35 0.712 -19.324 -15.646 1.00 1.00 O +ATOM 1101 OP2 C A 35 -1.380 -20.485 -14.728 1.00 1.00 O +ATOM 1102 O5' C A 35 -0.128 -18.816 -13.342 1.00 1.00 O +ATOM 1103 C5' C A 35 -0.246 -19.723 -12.243 1.00 1.00 C +ATOM 1104 C4' C A 35 0.471 -19.199 -11.004 1.00 1.00 C +ATOM 1105 O4' C A 35 -0.277 -18.130 -10.430 1.00 1.00 O +ATOM 1106 C3' C A 35 0.661 -20.243 -9.916 1.00 1.00 C +ATOM 1107 O3' C A 35 1.943 -20.857 -10.067 1.00 1.00 O +ATOM 1108 C2' C A 35 0.612 -19.443 -8.623 1.00 1.00 C +ATOM 1109 O2' C A 35 1.929 -19.106 -8.168 1.00 1.00 O +ATOM 1110 C1' C A 35 -0.185 -18.192 -9.001 1.00 1.00 C +ATOM 1111 N1 C A 35 -1.559 -18.181 -8.471 1.00 1.00 N +ATOM 1112 C2 C A 35 -1.716 -17.906 -7.122 1.00 1.00 C +ATOM 1113 O2 C A 35 -0.732 -17.685 -6.421 1.00 1.00 O +ATOM 1114 N3 C A 35 -2.977 -17.889 -6.610 1.00 1.00 N +ATOM 1115 C4 C A 35 -4.039 -18.133 -7.389 1.00 1.00 C +ATOM 1116 N4 C A 35 -5.261 -18.108 -6.856 1.00 1.00 N +ATOM 1117 C5 C A 35 -3.881 -18.418 -8.782 1.00 1.00 C +ATOM 1118 C6 C A 35 -2.629 -18.432 -9.279 1.00 1.00 C +ATOM 1119 H5' C A 35 0.188 -20.681 -12.524 1.00 1.00 H +ATOM 1120 H5'' C A 35 -1.301 -19.864 -12.011 1.00 1.00 H +ATOM 1121 H4' C A 35 1.446 -18.816 -11.300 1.00 1.00 H +ATOM 1122 H3' C A 35 -0.140 -20.983 -9.944 1.00 1.00 H +ATOM 1123 H2' C A 35 0.074 -20.009 -7.857 1.00 1.00 H +ATOM 1124 HO2' C A 35 2.274 -18.437 -8.762 1.00 1.00 H +ATOM 1125 H1' C A 35 0.342 -17.313 -8.639 1.00 1.00 H +ATOM 1126 H41 C A 35 -5.378 -17.907 -5.870 1.00 1.00 H +ATOM 1127 H42 C A 35 -6.069 -18.291 -7.434 1.00 1.00 H +ATOM 1128 H5 C A 35 -4.743 -18.618 -9.418 1.00 1.00 H +ATOM 1129 H6 C A 35 -2.470 -18.646 -10.335 1.00 1.00 H +ATOM 1130 P U A 36 2.216 -22.328 -9.477 1.00 1.00 P +ATOM 1131 OP1 U A 36 3.326 -22.938 -10.244 1.00 1.00 O +ATOM 1132 OP2 U A 36 0.919 -23.031 -9.371 1.00 1.00 O +ATOM 1133 O5' U A 36 2.742 -22.007 -7.991 1.00 1.00 O +ATOM 1134 C5' U A 36 2.183 -22.679 -6.862 1.00 1.00 C +ATOM 1135 C4' U A 36 2.435 -21.908 -5.568 1.00 1.00 C +ATOM 1136 O4' U A 36 1.411 -20.924 -5.377 1.00 1.00 O +ATOM 1137 C3' U A 36 2.451 -22.790 -4.329 1.00 1.00 C +ATOM 1138 O3' U A 36 3.801 -23.138 -4.006 1.00 1.00 O +ATOM 1139 C2' U A 36 1.875 -21.907 -3.235 1.00 1.00 C +ATOM 1140 O2' U A 36 2.909 -21.259 -2.489 1.00 1.00 O +ATOM 1141 C1' U A 36 1.026 -20.896 -3.996 1.00 1.00 C +ATOM 1142 N1 U A 36 -0.424 -21.160 -3.921 1.00 1.00 N +ATOM 1143 C2 U A 36 -1.000 -21.144 -2.666 1.00 1.00 C +ATOM 1144 O2 U A 36 -0.344 -20.940 -1.647 1.00 1.00 O +ATOM 1145 N3 U A 36 -2.364 -21.374 -2.621 1.00 1.00 N +ATOM 1146 C4 U A 36 -3.188 -21.615 -3.707 1.00 1.00 C +ATOM 1147 O4 U A 36 -4.392 -21.806 -3.551 1.00 1.00 O +ATOM 1148 C5 U A 36 -2.500 -21.612 -4.979 1.00 1.00 C +ATOM 1149 C6 U A 36 -1.165 -21.389 -5.047 1.00 1.00 C +ATOM 1150 H5' U A 36 2.632 -23.669 -6.779 1.00 1.00 H +ATOM 1151 H5'' U A 36 1.109 -22.788 -7.009 1.00 1.00 H +ATOM 1152 H4' U A 36 3.392 -21.397 -5.647 1.00 1.00 H +ATOM 1153 H3' U A 36 1.836 -23.679 -4.477 1.00 1.00 H +ATOM 1154 H2' U A 36 1.238 -22.502 -2.575 1.00 1.00 H +ATOM 1155 HO2' U A 36 2.707 -20.321 -2.477 1.00 1.00 H +ATOM 1156 H1' U A 36 1.219 -19.901 -3.594 1.00 1.00 H +ATOM 1157 H3 U A 36 -2.799 -21.366 -1.709 1.00 1.00 H +ATOM 1158 H5 U A 36 -3.063 -21.791 -5.895 1.00 1.00 H +ATOM 1159 H6 U A 36 -0.672 -21.394 -6.019 1.00 1.00 H +ATOM 1160 P A A 37 4.131 -24.477 -3.174 1.00 1.00 P +ATOM 1161 OP1 A A 37 5.595 -24.689 -3.204 1.00 1.00 O +ATOM 1162 OP2 A A 37 3.219 -25.546 -3.637 1.00 1.00 O +ATOM 1163 O5' A A 37 3.712 -24.073 -1.673 1.00 1.00 O +ATOM 1164 C5' A A 37 3.509 -25.082 -0.680 1.00 1.00 C +ATOM 1165 C4' A A 37 2.910 -24.503 0.598 1.00 1.00 C +ATOM 1166 O4' A A 37 1.786 -23.683 0.268 1.00 1.00 O +ATOM 1167 C3' A A 37 2.436 -25.560 1.589 1.00 1.00 C +ATOM 1168 O3' A A 37 2.735 -25.131 2.924 1.00 1.00 O +ATOM 1169 C2' A A 37 0.930 -25.615 1.385 1.00 1.00 C +ATOM 1170 O2' A A 37 0.245 -25.852 2.621 1.00 1.00 O +ATOM 1171 C1' A A 37 0.589 -24.243 0.818 1.00 1.00 C +ATOM 1172 N9 A A 37 -0.415 -24.275 -0.262 1.00 1.00 N +ATOM 1173 C8 A A 37 -0.230 -24.521 -1.597 1.00 1.00 C +ATOM 1174 N7 A A 37 -1.328 -24.476 -2.300 1.00 1.00 N +ATOM 1175 C5 A A 37 -2.311 -24.179 -1.361 1.00 1.00 C +ATOM 1176 C6 A A 37 -3.699 -23.994 -1.468 1.00 1.00 C +ATOM 1177 N6 A A 37 -4.362 -24.085 -2.622 1.00 1.00 N +ATOM 1178 N1 A A 37 -4.371 -23.711 -0.339 1.00 1.00 N +ATOM 1179 C2 A A 37 -3.706 -23.621 0.806 1.00 1.00 C +ATOM 1180 N3 A A 37 -2.410 -23.774 1.034 1.00 1.00 N +ATOM 1181 C4 A A 37 -1.763 -24.055 -0.116 1.00 1.00 C +ATOM 1182 H5' A A 37 4.468 -25.546 -0.445 1.00 1.00 H +ATOM 1183 H5'' A A 37 2.836 -25.842 -1.078 1.00 1.00 H +ATOM 1184 H4' A A 37 3.658 -23.879 1.084 1.00 1.00 H +ATOM 1185 H3' A A 37 2.894 -26.527 1.373 1.00 1.00 H +ATOM 1186 H2' A A 37 0.683 -26.390 0.655 1.00 1.00 H +ATOM 1187 HO2' A A 37 -0.294 -25.078 2.801 1.00 1.00 H +ATOM 1188 H1' A A 37 0.228 -23.602 1.621 1.00 1.00 H +ATOM 1189 H8 A A 37 0.747 -24.735 -2.033 1.00 1.00 H +ATOM 1190 H61 A A 37 -5.361 -23.943 -2.643 1.00 1.00 H +ATOM 1191 H62 A A 37 -3.863 -24.297 -3.474 1.00 1.00 H +ATOM 1192 H2 A A 37 -4.312 -23.389 1.682 1.00 1.00 H +ATOM 1193 P A A 38 3.031 -26.212 4.082 1.00 1.00 P +ATOM 1194 OP1 A A 38 4.469 -26.557 4.033 1.00 1.00 O +ATOM 1195 OP2 A A 38 2.012 -27.280 3.990 1.00 1.00 O +ATOM 1196 O5' A A 38 2.763 -25.372 5.431 1.00 1.00 O +ATOM 1197 C5' A A 38 3.842 -25.067 6.322 1.00 1.00 C +ATOM 1198 C4' A A 38 3.503 -23.892 7.234 1.00 1.00 C +ATOM 1199 O4' A A 38 3.326 -22.716 6.440 1.00 1.00 O +ATOM 1200 C3' A A 38 2.232 -24.092 8.053 1.00 1.00 C +ATOM 1201 O3' A A 38 2.578 -24.493 9.386 1.00 1.00 O +ATOM 1202 C2' A A 38 1.597 -22.714 8.085 1.00 1.00 C +ATOM 1203 O2' A A 38 1.998 -21.980 9.248 1.00 1.00 O +ATOM 1204 C1' A A 38 2.110 -22.059 6.809 1.00 1.00 C +ATOM 1205 N9 A A 38 1.180 -22.169 5.670 1.00 1.00 N +ATOM 1206 C8 A A 38 1.311 -22.902 4.520 1.00 1.00 C +ATOM 1207 N7 A A 38 0.299 -22.790 3.704 1.00 1.00 N +ATOM 1208 C5 A A 38 -0.564 -21.919 4.363 1.00 1.00 C +ATOM 1209 C6 A A 38 -1.822 -21.393 4.025 1.00 1.00 C +ATOM 1210 N6 A A 38 -2.454 -21.682 2.887 1.00 1.00 N +ATOM 1211 N1 A A 38 -2.397 -20.558 4.907 1.00 1.00 N +ATOM 1212 C2 A A 38 -1.763 -20.273 6.038 1.00 1.00 C +ATOM 1213 N3 A A 38 -0.586 -20.702 6.467 1.00 1.00 N +ATOM 1214 C4 A A 38 -0.034 -21.536 5.562 1.00 1.00 C +ATOM 1215 H5' A A 38 4.728 -24.820 5.738 1.00 1.00 H +ATOM 1216 H5'' A A 38 4.054 -25.944 6.936 1.00 1.00 H +ATOM 1217 H4' A A 38 4.337 -23.724 7.913 1.00 1.00 H +ATOM 1218 H3' A A 38 1.570 -24.818 7.578 1.00 1.00 H +ATOM 1219 H2' A A 38 0.511 -22.804 8.043 1.00 1.00 H +ATOM 1220 HO2' A A 38 2.919 -21.737 9.130 1.00 1.00 H +ATOM 1221 H1' A A 38 2.313 -21.006 6.999 1.00 1.00 H +ATOM 1222 H8 A A 38 2.182 -23.523 4.306 1.00 1.00 H +ATOM 1223 H61 A A 38 -3.358 -21.276 2.693 1.00 1.00 H +ATOM 1224 H62 A A 38 -2.029 -22.308 2.219 1.00 1.00 H +ATOM 1225 H2 A A 38 -2.286 -19.589 6.708 1.00 1.00 H +ATOM 1226 P G A 39 1.599 -25.444 10.246 1.00 1.00 P +ATOM 1227 OP1 G A 39 2.244 -25.704 11.553 1.00 1.00 O +ATOM 1228 OP2 G A 39 1.187 -26.578 9.390 1.00 1.00 O +ATOM 1229 O5' G A 39 0.311 -24.510 10.501 1.00 1.00 O +ATOM 1230 C5' G A 39 0.410 -23.336 11.311 1.00 1.00 C +ATOM 1231 C4' G A 39 -0.862 -22.494 11.242 1.00 1.00 C +ATOM 1232 O4' G A 39 -1.060 -22.057 9.895 1.00 1.00 O +ATOM 1233 C3' G A 39 -2.127 -23.233 11.669 1.00 1.00 C +ATOM 1234 O3' G A 39 -2.470 -22.862 13.007 1.00 1.00 O +ATOM 1235 C2' G A 39 -3.195 -22.717 10.719 1.00 1.00 C +ATOM 1236 O2' G A 39 -3.881 -21.585 11.267 1.00 1.00 O +ATOM 1237 C1' G A 39 -2.401 -22.338 9.478 1.00 1.00 C +ATOM 1238 N9 G A 39 -2.339 -23.405 8.461 1.00 1.00 N +ATOM 1239 C8 G A 39 -1.438 -24.432 8.345 1.00 1.00 C +ATOM 1240 N7 G A 39 -1.658 -25.215 7.328 1.00 1.00 N +ATOM 1241 C5 G A 39 -2.786 -24.670 6.721 1.00 1.00 C +ATOM 1242 C6 G A 39 -3.494 -25.096 5.565 1.00 1.00 C +ATOM 1243 O6 G A 39 -3.258 -26.056 4.836 1.00 1.00 O +ATOM 1244 N1 G A 39 -4.575 -24.266 5.295 1.00 1.00 N +ATOM 1245 C2 G A 39 -4.932 -23.164 6.043 1.00 1.00 C +ATOM 1246 N2 G A 39 -6.002 -22.490 5.625 1.00 1.00 N +ATOM 1247 N3 G A 39 -4.267 -22.763 7.131 1.00 1.00 N +ATOM 1248 C4 G A 39 -3.210 -23.560 7.409 1.00 1.00 C +ATOM 1249 H5' G A 39 1.253 -22.734 10.966 1.00 1.00 H +ATOM 1250 H5'' G A 39 0.585 -23.631 12.345 1.00 1.00 H +ATOM 1251 H4' G A 39 -0.737 -21.617 11.872 1.00 1.00 H +ATOM 1252 H3' G A 39 -2.005 -24.313 11.572 1.00 1.00 H +ATOM 1253 H2' G A 39 -3.899 -23.514 10.479 1.00 1.00 H +ATOM 1254 HO2' G A 39 -3.242 -20.873 11.341 1.00 1.00 H +ATOM 1255 H1' G A 39 -2.834 -21.444 9.032 1.00 1.00 H +ATOM 1256 H8 G A 39 -0.612 -24.579 9.042 1.00 1.00 H +ATOM 1257 H1 G A 39 -5.128 -24.506 4.485 1.00 1.00 H +ATOM 1258 H21 G A 39 -6.502 -22.795 4.804 1.00 1.00 H +ATOM 1259 H22 G A 39 -6.313 -21.673 6.133 1.00 1.00 H +ATOM 1260 P U A 40 -3.321 -23.859 13.940 1.00 1.00 P +ATOM 1261 OP1 U A 40 -4.025 -23.052 14.960 1.00 1.00 O +ATOM 1262 OP2 U A 40 -2.437 -24.971 14.358 1.00 1.00 O +ATOM 1263 O5' U A 40 -4.419 -24.448 12.920 1.00 1.00 O +ATOM 1264 C5' U A 40 -5.661 -23.770 12.709 1.00 1.00 C +ATOM 1265 C4' U A 40 -6.640 -24.643 11.930 1.00 1.00 C +ATOM 1266 O4' U A 40 -6.216 -24.781 10.581 1.00 1.00 O +ATOM 1267 C3' U A 40 -6.775 -26.052 12.479 1.00 1.00 C +ATOM 1268 O3' U A 40 -7.797 -26.092 13.481 1.00 1.00 O +ATOM 1269 C2' U A 40 -7.186 -26.867 11.262 1.00 1.00 C +ATOM 1270 O2' U A 40 -8.607 -27.026 11.190 1.00 1.00 O +ATOM 1271 C1' U A 40 -6.654 -26.052 10.081 1.00 1.00 C +ATOM 1272 N1 U A 40 -5.502 -26.675 9.397 1.00 1.00 N +ATOM 1273 C2 U A 40 -5.763 -27.517 8.333 1.00 1.00 C +ATOM 1274 O2 U A 40 -6.908 -27.767 7.962 1.00 1.00 O +ATOM 1275 N3 U A 40 -4.659 -28.064 7.707 1.00 1.00 N +ATOM 1276 C4 U A 40 -3.334 -27.846 8.049 1.00 1.00 C +ATOM 1277 O4 U A 40 -2.427 -28.387 7.418 1.00 1.00 O +ATOM 1278 C5 U A 40 -3.156 -26.953 9.171 1.00 1.00 C +ATOM 1279 C6 U A 40 -4.224 -26.405 9.800 1.00 1.00 C +ATOM 1280 H5' U A 40 -5.477 -22.852 12.148 1.00 1.00 H +ATOM 1281 H5'' U A 40 -6.099 -23.518 13.673 1.00 1.00 H +ATOM 1282 H4' U A 40 -7.619 -24.164 11.936 1.00 1.00 H +ATOM 1283 H3' U A 40 -5.818 -26.404 12.873 1.00 1.00 H +ATOM 1284 H2' U A 40 -6.693 -27.839 11.288 1.00 1.00 H +ATOM 1285 HO2' U A 40 -8.783 -27.750 10.584 1.00 1.00 H +ATOM 1286 H1' U A 40 -7.459 -25.897 9.365 1.00 1.00 H +ATOM 1287 H3 U A 40 -4.834 -28.681 6.926 1.00 1.00 H +ATOM 1288 H5 U A 40 -2.149 -26.718 9.517 1.00 1.00 H +ATOM 1289 H6 U A 40 -4.059 -25.735 10.645 1.00 1.00 H +ATOM 1290 P C A 41 -7.741 -27.188 14.663 1.00 1.00 P +ATOM 1291 OP1 C A 41 -8.820 -26.887 15.629 1.00 1.00 O +ATOM 1292 OP2 C A 41 -6.341 -27.291 15.130 1.00 1.00 O +ATOM 1293 O5' C A 41 -8.116 -28.556 13.900 1.00 1.00 O +ATOM 1294 C5' C A 41 -9.473 -28.853 13.563 1.00 1.00 C +ATOM 1295 C4' C A 41 -9.565 -30.026 12.591 1.00 1.00 C +ATOM 1296 O4' C A 41 -8.718 -29.796 11.474 1.00 1.00 O +ATOM 1297 C3' C A 41 -9.131 -31.361 13.170 1.00 1.00 C +ATOM 1298 O3' C A 41 -10.248 -32.016 13.786 1.00 1.00 O +ATOM 1299 C2' C A 41 -8.675 -32.144 11.947 1.00 1.00 C +ATOM 1300 O2' C A 41 -9.719 -32.985 11.440 1.00 1.00 O +ATOM 1301 C1' C A 41 -8.290 -31.058 10.940 1.00 1.00 C +ATOM 1302 N1 C A 41 -6.838 -30.972 10.705 1.00 1.00 N +ATOM 1303 C2 C A 41 -6.322 -31.616 9.590 1.00 1.00 C +ATOM 1304 O2 C A 41 -7.070 -32.233 8.835 1.00 1.00 O +ATOM 1305 N3 C A 41 -4.980 -31.544 9.366 1.00 1.00 N +ATOM 1306 C4 C A 41 -4.179 -30.869 10.201 1.00 1.00 C +ATOM 1307 N4 C A 41 -2.870 -30.818 9.954 1.00 1.00 N +ATOM 1308 C5 C A 41 -4.707 -30.202 11.351 1.00 1.00 C +ATOM 1309 C6 C A 41 -6.035 -30.279 11.564 1.00 1.00 C +ATOM 1310 H5' C A 41 -9.932 -27.973 13.108 1.00 1.00 H +ATOM 1311 H5'' C A 41 -10.016 -29.106 14.472 1.00 1.00 H +ATOM 1312 H4' C A 41 -10.590 -30.109 12.235 1.00 1.00 H +ATOM 1313 H3' C A 41 -8.307 -31.229 13.876 1.00 1.00 H +ATOM 1314 H2' C A 41 -7.794 -32.732 12.199 1.00 1.00 H +ATOM 1315 HO2' C A 41 -10.522 -32.460 11.424 1.00 1.00 H +ATOM 1316 H1' C A 41 -8.804 -31.240 9.998 1.00 1.00 H +ATOM 1317 H41 C A 41 -2.494 -31.284 9.149 1.00 1.00 H +ATOM 1318 H42 C A 41 -2.258 -30.312 10.576 1.00 1.00 H +ATOM 1319 H5 C A 41 -4.058 -29.652 12.032 1.00 1.00 H +ATOM 1320 H6 C A 41 -6.472 -29.784 12.430 1.00 1.00 H +ATOM 1321 P C A 42 -10.018 -33.232 14.819 1.00 1.00 P +ATOM 1322 OP1 C A 42 -11.294 -33.499 15.516 1.00 1.00 O +ATOM 1323 OP2 C A 42 -8.796 -32.945 15.603 1.00 1.00 O +ATOM 1324 O5' C A 42 -9.710 -34.477 13.845 1.00 1.00 O +ATOM 1325 C5' C A 42 -10.776 -35.129 13.147 1.00 1.00 C +ATOM 1326 C4' C A 42 -10.253 -36.087 12.079 1.00 1.00 C +ATOM 1327 O4' C A 42 -9.311 -35.420 11.246 1.00 1.00 O +ATOM 1328 C3' C A 42 -9.530 -37.309 12.621 1.00 1.00 C +ATOM 1329 O3' C A 42 -10.458 -38.369 12.869 1.00 1.00 O +ATOM 1330 C2' C A 42 -8.608 -37.699 11.478 1.00 1.00 C +ATOM 1331 O2' C A 42 -9.212 -38.680 10.630 1.00 1.00 O +ATOM 1332 C1' C A 42 -8.383 -36.388 10.730 1.00 1.00 C +ATOM 1333 N1 C A 42 -7.020 -35.844 10.891 1.00 1.00 N +ATOM 1334 C2 C A 42 -6.087 -36.141 9.911 1.00 1.00 C +ATOM 1335 O2 C A 42 -6.399 -36.855 8.961 1.00 1.00 O +ATOM 1336 N3 C A 42 -4.832 -35.627 10.036 1.00 1.00 N +ATOM 1337 C4 C A 42 -4.507 -34.852 11.081 1.00 1.00 C +ATOM 1338 N4 C A 42 -3.270 -34.364 11.172 1.00 1.00 N +ATOM 1339 C5 C A 42 -5.467 -34.544 12.096 1.00 1.00 C +ATOM 1340 C6 C A 42 -6.706 -35.057 11.962 1.00 1.00 C +ATOM 1341 H5' C A 42 -11.406 -34.375 12.671 1.00 1.00 H +ATOM 1342 H5'' C A 42 -11.377 -35.691 13.861 1.00 1.00 H +ATOM 1343 H4' C A 42 -11.087 -36.413 11.461 1.00 1.00 H +ATOM 1344 H3' C A 42 -8.958 -37.058 13.518 1.00 1.00 H +ATOM 1345 H2' C A 42 -7.664 -38.064 11.876 1.00 1.00 H +ATOM 1346 HO2' C A 42 -9.860 -38.227 10.090 1.00 1.00 H +ATOM 1347 H1' C A 42 -8.586 -36.541 9.671 1.00 1.00 H +ATOM 1348 H41 C A 42 -2.587 -34.583 10.456 1.00 1.00 H +ATOM 1349 H42 C A 42 -3.014 -33.781 11.954 1.00 1.00 H +ATOM 1350 H5 C A 42 -5.206 -33.914 12.947 1.00 1.00 H +ATOM 1351 H6 C A 42 -7.462 -34.845 12.717 1.00 1.00 H +ATOM 1352 P U A 43 -10.015 -39.642 13.753 1.00 1.00 P +ATOM 1353 OP1 U A 43 -11.069 -40.677 13.641 1.00 1.00 O +ATOM 1354 OP2 U A 43 -9.596 -39.159 15.087 1.00 1.00 O +ATOM 1355 O5' U A 43 -8.705 -40.172 12.977 1.00 1.00 O +ATOM 1356 C5' U A 43 -8.833 -40.907 11.757 1.00 1.00 C +ATOM 1357 C4' U A 43 -7.477 -41.356 11.214 1.00 1.00 C +ATOM 1358 O4' U A 43 -6.638 -40.233 10.976 1.00 1.00 O +ATOM 1359 C3' U A 43 -6.701 -42.272 12.151 1.00 1.00 C +ATOM 1360 O3' U A 43 -6.957 -43.651 11.858 1.00 1.00 O +ATOM 1361 C2' U A 43 -5.234 -41.912 11.895 1.00 1.00 C +ATOM 1362 O2' U A 43 -4.526 -42.998 11.287 1.00 1.00 O +ATOM 1363 C1' U A 43 -5.291 -40.706 10.967 1.00 1.00 C +ATOM 1364 N1 U A 43 -4.399 -39.602 11.386 1.00 1.00 N +ATOM 1365 C2 U A 43 -3.147 -39.539 10.803 1.00 1.00 C +ATOM 1366 O2 U A 43 -2.773 -40.359 9.967 1.00 1.00 O +ATOM 1367 N3 U A 43 -2.337 -38.497 11.216 1.00 1.00 N +ATOM 1368 C4 U A 43 -2.665 -37.527 12.147 1.00 1.00 C +ATOM 1369 O4 U A 43 -1.864 -36.639 12.437 1.00 1.00 O +ATOM 1370 C5 U A 43 -3.992 -37.672 12.705 1.00 1.00 C +ATOM 1371 C6 U A 43 -4.803 -38.684 12.316 1.00 1.00 C +ATOM 1372 H5' U A 43 -9.324 -40.279 11.013 1.00 1.00 H +ATOM 1373 H5'' U A 43 -9.447 -41.787 11.939 1.00 1.00 H +ATOM 1374 H4' U A 43 -7.631 -41.875 10.269 1.00 1.00 H +ATOM 1375 H3' U A 43 -6.960 -42.046 13.190 1.00 1.00 H +ATOM 1376 HO3' U A 43 -7.731 -43.910 12.361 1.00 1.00 H +ATOM 1377 H2' U A 43 -4.755 -41.619 12.830 1.00 1.00 H +ATOM 1378 HO2' U A 43 -4.254 -42.705 10.412 1.00 1.00 H +ATOM 1379 H1' U A 43 -5.031 -41.020 9.953 1.00 1.00 H +ATOM 1380 H3 U A 43 -1.419 -38.438 10.797 1.00 1.00 H +ATOM 1381 H5 U A 43 -4.344 -36.957 13.448 1.00 1.00 H +ATOM 1382 H6 U A 43 -5.798 -38.770 12.752 1.00 1.00 H +TER 1383 U A 43 +ATOM 1384 O5' G B 44 -5.645 35.018 17.071 1.00 1.00 O +ATOM 1385 C5' G B 44 -6.697 35.713 16.398 1.00 1.00 C +ATOM 1386 C4' G B 44 -6.144 36.683 15.356 1.00 1.00 C +ATOM 1387 O4' G B 44 -5.479 37.765 16.013 1.00 1.00 O +ATOM 1388 C3' G B 44 -5.149 36.043 14.392 1.00 1.00 C +ATOM 1389 O3' G B 44 -5.784 35.807 13.132 1.00 1.00 O +ATOM 1390 C2' G B 44 -4.063 37.092 14.227 1.00 1.00 C +ATOM 1391 O2' G B 44 -4.320 37.941 13.104 1.00 1.00 O +ATOM 1392 C1' G B 44 -4.136 37.862 15.534 1.00 1.00 C +ATOM 1393 N9 G B 44 -3.256 37.327 16.581 1.00 1.00 N +ATOM 1394 C8 G B 44 -3.596 36.611 17.700 1.00 1.00 C +ATOM 1395 N7 G B 44 -2.578 36.269 18.437 1.00 1.00 N +ATOM 1396 C5 G B 44 -1.482 36.798 17.763 1.00 1.00 C +ATOM 1397 C6 G B 44 -0.099 36.745 18.091 1.00 1.00 C +ATOM 1398 O6 G B 44 0.435 36.208 19.058 1.00 1.00 O +ATOM 1399 N1 G B 44 0.674 37.405 17.145 1.00 1.00 N +ATOM 1400 C2 G B 44 0.184 38.037 16.023 1.00 1.00 C +ATOM 1401 N2 G B 44 1.086 38.617 15.231 1.00 1.00 N +ATOM 1402 N3 G B 44 -1.117 38.089 15.712 1.00 1.00 N +ATOM 1403 C4 G B 44 -1.887 37.449 16.624 1.00 1.00 C +ATOM 1404 H5' G B 44 -7.286 36.263 17.134 1.00 1.00 H +ATOM 1405 H5'' G B 44 -7.340 34.993 15.898 1.00 1.00 H +ATOM 1406 H4' G B 44 -6.975 37.089 14.783 1.00 1.00 H +ATOM 1407 H3' G B 44 -4.739 35.121 14.809 1.00 1.00 H +ATOM 1408 H2' G B 44 -3.088 36.611 14.135 1.00 1.00 H +ATOM 1409 HO2' G B 44 -4.806 38.703 13.427 1.00 1.00 H +ATOM 1410 H1' G B 44 -3.887 38.908 15.357 1.00 1.00 H +ATOM 1411 H8 G B 44 -4.625 36.351 17.950 1.00 1.00 H +ATOM 1412 H1 G B 44 1.670 37.408 17.311 1.00 1.00 H +ATOM 1413 H21 G B 44 2.066 38.577 15.468 1.00 1.00 H +ATOM 1414 H22 G B 44 0.787 39.097 14.393 1.00 1.00 H +ATOM 1415 HO5' G B 44 -5.702 34.095 16.812 1.00 1.00 H +ATOM 1416 P G B 45 -5.316 34.587 12.191 1.00 1.00 P +ATOM 1417 OP1 G B 45 -6.077 34.667 10.923 1.00 1.00 O +ATOM 1418 OP2 G B 45 -5.351 33.344 12.993 1.00 1.00 O +ATOM 1419 O5' G B 45 -3.776 34.945 11.883 1.00 1.00 O +ATOM 1420 C5' G B 45 -3.431 36.136 11.167 1.00 1.00 C +ATOM 1421 C4' G B 45 -1.918 36.338 11.107 1.00 1.00 C +ATOM 1422 O4' G B 45 -1.396 36.557 12.417 1.00 1.00 O +ATOM 1423 C3' G B 45 -1.158 35.153 10.533 1.00 1.00 C +ATOM 1424 O3' G B 45 -1.003 35.330 9.120 1.00 1.00 O +ATOM 1425 C2' G B 45 0.202 35.225 11.213 1.00 1.00 C +ATOM 1426 O2' G B 45 1.171 35.858 10.373 1.00 1.00 O +ATOM 1427 C1' G B 45 -0.057 36.042 12.480 1.00 1.00 C +ATOM 1428 N9 G B 45 0.090 35.270 13.725 1.00 1.00 N +ATOM 1429 C8 G B 45 -0.870 34.659 14.491 1.00 1.00 C +ATOM 1430 N7 G B 45 -0.399 34.058 15.548 1.00 1.00 N +ATOM 1431 C5 G B 45 0.973 34.287 15.481 1.00 1.00 C +ATOM 1432 C6 G B 45 2.011 33.873 16.361 1.00 1.00 C +ATOM 1433 O6 G B 45 1.918 33.211 17.393 1.00 1.00 O +ATOM 1434 N1 G B 45 3.253 34.315 15.927 1.00 1.00 N +ATOM 1435 C2 G B 45 3.473 35.060 14.787 1.00 1.00 C +ATOM 1436 N2 G B 45 4.739 35.391 14.534 1.00 1.00 N +ATOM 1437 N3 G B 45 2.501 35.450 13.959 1.00 1.00 N +ATOM 1438 C4 G B 45 1.281 35.028 14.367 1.00 1.00 C +ATOM 1439 H5' G B 45 -3.886 36.994 11.661 1.00 1.00 H +ATOM 1440 H5'' G B 45 -3.819 36.064 10.152 1.00 1.00 H +ATOM 1441 H4' G B 45 -1.707 37.217 10.499 1.00 1.00 H +ATOM 1442 H3' G B 45 -1.664 34.214 10.767 1.00 1.00 H +ATOM 1443 H2' G B 45 0.529 34.219 11.487 1.00 1.00 H +ATOM 1444 HO2' G B 45 2.006 35.402 10.503 1.00 1.00 H +ATOM 1445 H1' G B 45 0.641 36.877 12.511 1.00 1.00 H +ATOM 1446 H8 G B 45 -1.930 34.671 14.238 1.00 1.00 H +ATOM 1447 H1 G B 45 4.042 34.059 16.503 1.00 1.00 H +ATOM 1448 H21 G B 45 5.469 35.098 15.159 1.00 1.00 H +ATOM 1449 H22 G B 45 4.964 35.937 13.717 1.00 1.00 H +ATOM 1450 P G B 46 -0.548 34.106 8.177 1.00 1.00 P +ATOM 1451 OP1 G B 46 -1.016 34.381 6.800 1.00 1.00 O +ATOM 1452 OP2 G B 46 -0.925 32.839 8.845 1.00 1.00 O +ATOM 1453 O5' G B 46 1.058 34.229 8.197 1.00 1.00 O +ATOM 1454 C5' G B 46 1.705 35.425 7.749 1.00 1.00 C +ATOM 1455 C4' G B 46 3.185 35.430 8.118 1.00 1.00 C +ATOM 1456 O4' G B 46 3.314 35.389 9.538 1.00 1.00 O +ATOM 1457 C3' G B 46 3.966 34.249 7.559 1.00 1.00 C +ATOM 1458 O3' G B 46 4.612 34.633 6.338 1.00 1.00 O +ATOM 1459 C2' G B 46 5.009 33.968 8.630 1.00 1.00 C +ATOM 1460 O2' G B 46 6.230 34.669 8.374 1.00 1.00 O +ATOM 1461 C1' G B 46 4.340 34.461 9.910 1.00 1.00 C +ATOM 1462 N9 G B 46 3.703 33.392 10.694 1.00 1.00 N +ATOM 1463 C8 G B 46 2.465 32.825 10.533 1.00 1.00 C +ATOM 1464 N7 G B 46 2.191 31.896 11.407 1.00 1.00 N +ATOM 1465 C5 G B 46 3.329 31.841 12.206 1.00 1.00 C +ATOM 1466 C6 G B 46 3.616 31.015 13.327 1.00 1.00 C +ATOM 1467 O6 G B 46 2.906 30.155 13.845 1.00 1.00 O +ATOM 1468 N1 G B 46 4.878 31.280 13.845 1.00 1.00 N +ATOM 1469 C2 G B 46 5.754 32.220 13.347 1.00 1.00 C +ATOM 1470 N2 G B 46 6.923 32.329 13.978 1.00 1.00 N +ATOM 1471 N3 G B 46 5.486 32.997 12.294 1.00 1.00 N +ATOM 1472 C4 G B 46 4.260 32.754 11.777 1.00 1.00 C +ATOM 1473 H5' G B 46 1.221 36.287 8.210 1.00 1.00 H +ATOM 1474 H5'' G B 46 1.608 35.499 6.667 1.00 1.00 H +ATOM 1475 H4' G B 46 3.634 36.354 7.759 1.00 1.00 H +ATOM 1476 H3' G B 46 3.315 33.385 7.413 1.00 1.00 H +ATOM 1477 H2' G B 46 5.187 32.894 8.701 1.00 1.00 H +ATOM 1478 HO2' G B 46 6.945 34.137 8.730 1.00 1.00 H +ATOM 1479 H1' G B 46 5.076 34.967 10.536 1.00 1.00 H +ATOM 1480 H8 G B 46 1.772 33.123 9.745 1.00 1.00 H +ATOM 1481 H1 G B 46 5.154 30.730 14.646 1.00 1.00 H +ATOM 1482 H21 G B 46 7.126 31.738 14.774 1.00 1.00 H +ATOM 1483 H22 G B 46 7.608 33.000 13.660 1.00 1.00 H +ATOM 1484 P A B 47 4.489 33.714 5.018 1.00 1.00 P +ATOM 1485 OP1 A B 47 4.730 34.571 3.835 1.00 1.00 O +ATOM 1486 OP2 A B 47 3.239 32.929 5.115 1.00 1.00 O +ATOM 1487 O5' A B 47 5.735 32.704 5.167 1.00 1.00 O +ATOM 1488 C5' A B 47 7.078 33.167 5.003 1.00 1.00 C +ATOM 1489 C4' A B 47 8.086 32.155 5.539 1.00 1.00 C +ATOM 1490 O4' A B 47 7.921 32.016 6.947 1.00 1.00 O +ATOM 1491 C3' A B 47 7.948 30.763 4.940 1.00 1.00 C +ATOM 1492 O3' A B 47 8.815 30.634 3.811 1.00 1.00 O +ATOM 1493 C2' A B 47 8.421 29.850 6.058 1.00 1.00 C +ATOM 1494 O2' A B 47 9.823 29.576 5.951 1.00 1.00 O +ATOM 1495 C1' A B 47 8.102 30.643 7.321 1.00 1.00 C +ATOM 1496 N9 A B 47 6.871 30.203 7.999 1.00 1.00 N +ATOM 1497 C8 A B 47 5.573 30.564 7.740 1.00 1.00 C +ATOM 1498 N7 A B 47 4.700 29.994 8.525 1.00 1.00 N +ATOM 1499 C5 A B 47 5.476 29.200 9.365 1.00 1.00 C +ATOM 1500 C6 A B 47 5.148 28.339 10.424 1.00 1.00 C +ATOM 1501 N6 A B 47 3.895 28.129 10.833 1.00 1.00 N +ATOM 1502 N1 A B 47 6.161 27.707 11.041 1.00 1.00 N +ATOM 1503 C2 A B 47 7.404 27.920 10.629 1.00 1.00 C +ATOM 1504 N3 A B 47 7.839 28.702 9.650 1.00 1.00 N +ATOM 1505 C4 A B 47 6.800 29.322 9.052 1.00 1.00 C +ATOM 1506 H5' A B 47 7.200 34.108 5.540 1.00 1.00 H +ATOM 1507 H5'' A B 47 7.272 33.334 3.944 1.00 1.00 H +ATOM 1508 H4' A B 47 9.091 32.524 5.347 1.00 1.00 H +ATOM 1509 H3' A B 47 6.910 30.552 4.676 1.00 1.00 H +ATOM 1510 H2' A B 47 7.846 28.922 6.048 1.00 1.00 H +ATOM 1511 HO2' A B 47 10.227 29.830 6.783 1.00 1.00 H +ATOM 1512 H1' A B 47 8.937 30.568 8.018 1.00 1.00 H +ATOM 1513 H8 A B 47 5.295 31.260 6.949 1.00 1.00 H +ATOM 1514 H61 A B 47 3.714 27.501 11.598 1.00 1.00 H +ATOM 1515 H62 A B 47 3.131 28.602 10.373 1.00 1.00 H +ATOM 1516 H2 A B 47 8.177 27.376 11.172 1.00 1.00 H +ATOM 1517 P U B 48 8.457 29.611 2.621 1.00 1.00 P +ATOM 1518 OP1 U B 48 9.651 29.467 1.759 1.00 1.00 O +ATOM 1519 OP2 U B 48 7.165 30.026 2.028 1.00 1.00 O +ATOM 1520 O5' U B 48 8.229 28.223 3.401 1.00 1.00 O +ATOM 1521 C5' U B 48 9.329 27.510 3.970 1.00 1.00 C +ATOM 1522 C4' U B 48 8.851 26.282 4.739 1.00 1.00 C +ATOM 1523 O4' U B 48 8.139 26.679 5.899 1.00 1.00 O +ATOM 1524 C3' U B 48 7.914 25.383 3.955 1.00 1.00 C +ATOM 1525 O3' U B 48 8.684 24.412 3.238 1.00 1.00 O +ATOM 1526 C2' U B 48 7.077 24.707 5.040 1.00 1.00 C +ATOM 1527 O2' U B 48 7.582 23.403 5.360 1.00 1.00 O +ATOM 1528 C1' U B 48 7.183 25.665 6.236 1.00 1.00 C +ATOM 1529 N1 U B 48 5.913 26.345 6.581 1.00 1.00 N +ATOM 1530 C2 U B 48 5.170 25.816 7.619 1.00 1.00 C +ATOM 1531 O2 U B 48 5.531 24.816 8.236 1.00 1.00 O +ATOM 1532 N3 U B 48 3.996 26.479 7.925 1.00 1.00 N +ATOM 1533 C4 U B 48 3.506 27.609 7.292 1.00 1.00 C +ATOM 1534 O4 U B 48 2.446 28.117 7.649 1.00 1.00 O +ATOM 1535 C5 U B 48 4.347 28.092 6.220 1.00 1.00 C +ATOM 1536 C6 U B 48 5.503 27.459 5.901 1.00 1.00 C +ATOM 1537 H5' U B 48 9.870 28.168 4.652 1.00 1.00 H +ATOM 1538 H5'' U B 48 10.001 27.192 3.173 1.00 1.00 H +ATOM 1539 H4' U B 48 9.720 25.702 5.049 1.00 1.00 H +ATOM 1540 H3' U B 48 7.284 25.968 3.282 1.00 1.00 H +ATOM 1541 H2' U B 48 6.036 24.646 4.710 1.00 1.00 H +ATOM 1542 HO2' U B 48 8.505 23.503 5.596 1.00 1.00 H +ATOM 1543 H1' U B 48 7.546 25.111 7.102 1.00 1.00 H +ATOM 1544 H3 U B 48 3.443 26.103 8.682 1.00 1.00 H +ATOM 1545 H5 U B 48 4.047 28.978 5.659 1.00 1.00 H +ATOM 1546 H6 U B 48 6.117 27.846 5.089 1.00 1.00 H +ATOM 1547 P A B 49 8.113 23.739 1.892 1.00 1.00 P +ATOM 1548 OP1 A B 49 8.407 24.645 0.759 1.00 1.00 O +ATOM 1549 OP2 A B 49 6.722 23.304 2.148 1.00 1.00 O +ATOM 1550 O5' A B 49 9.033 22.426 1.739 1.00 1.00 O +ATOM 1551 C5' A B 49 10.148 22.216 2.610 1.00 1.00 C +ATOM 1552 C4' A B 49 9.984 20.940 3.430 1.00 1.00 C +ATOM 1553 O4' A B 49 8.694 20.944 4.049 1.00 1.00 O +ATOM 1554 C3' A B 49 10.108 19.651 2.611 1.00 1.00 C +ATOM 1555 O3' A B 49 11.057 18.780 3.238 1.00 1.00 O +ATOM 1556 C2' A B 49 8.723 19.016 2.664 1.00 1.00 C +ATOM 1557 O2' A B 49 8.806 17.595 2.820 1.00 1.00 O +ATOM 1558 C1' A B 49 8.080 19.669 3.877 1.00 1.00 C +ATOM 1559 N9 A B 49 6.623 19.878 3.754 1.00 1.00 N +ATOM 1560 C8 A B 49 5.937 20.677 2.876 1.00 1.00 C +ATOM 1561 N7 A B 49 4.642 20.640 3.031 1.00 1.00 N +ATOM 1562 C5 A B 49 4.459 19.753 4.087 1.00 1.00 C +ATOM 1563 C6 A B 49 3.310 19.279 4.741 1.00 1.00 C +ATOM 1564 N6 A B 49 2.074 19.653 4.411 1.00 1.00 N +ATOM 1565 N1 A B 49 3.489 18.406 5.747 1.00 1.00 N +ATOM 1566 C2 A B 49 4.722 18.036 6.073 1.00 1.00 C +ATOM 1567 N3 A B 49 5.875 18.409 5.537 1.00 1.00 N +ATOM 1568 C4 A B 49 5.661 19.283 4.532 1.00 1.00 C +ATOM 1569 H5' A B 49 10.235 23.065 3.287 1.00 1.00 H +ATOM 1570 H5'' A B 49 11.058 22.142 2.014 1.00 1.00 H +ATOM 1571 H4' A B 49 10.739 20.929 4.214 1.00 1.00 H +ATOM 1572 H3' A B 49 10.396 19.870 1.580 1.00 1.00 H +ATOM 1573 H2' A B 49 8.162 19.272 1.760 1.00 1.00 H +ATOM 1574 HO2' A B 49 7.910 17.267 2.930 1.00 1.00 H +ATOM 1575 H1' A B 49 8.277 19.058 4.756 1.00 1.00 H +ATOM 1576 H8 A B 49 6.429 21.286 2.116 1.00 1.00 H +ATOM 1577 H61 A B 49 1.283 19.280 4.917 1.00 1.00 H +ATOM 1578 H62 A B 49 1.924 20.308 3.657 1.00 1.00 H +ATOM 1579 H2 A B 49 4.797 17.326 6.896 1.00 1.00 H +ATOM 1580 P U B 50 11.378 17.332 2.611 1.00 1.00 P +ATOM 1581 OP1 U B 50 12.833 17.086 2.731 1.00 1.00 O +ATOM 1582 OP2 U B 50 10.723 17.244 1.287 1.00 1.00 O +ATOM 1583 O5' U B 50 10.610 16.337 3.620 1.00 1.00 O +ATOM 1584 C5' U B 50 11.341 15.580 4.590 1.00 1.00 C +ATOM 1585 C4' U B 50 10.545 15.398 5.884 1.00 1.00 C +ATOM 1586 O4' U B 50 10.604 16.606 6.648 1.00 1.00 O +ATOM 1587 C3' U B 50 9.067 15.062 5.663 1.00 1.00 C +ATOM 1588 O3' U B 50 8.736 13.850 6.347 1.00 1.00 O +ATOM 1589 C2' U B 50 8.303 16.214 6.301 1.00 1.00 C +ATOM 1590 O2' U B 50 7.171 15.751 7.038 1.00 1.00 O +ATOM 1591 C1' U B 50 9.323 16.855 7.222 1.00 1.00 C +ATOM 1592 N1 U B 50 9.154 18.315 7.381 1.00 1.00 N +ATOM 1593 C2 U B 50 10.289 19.065 7.623 1.00 1.00 C +ATOM 1594 O2 U B 50 11.404 18.554 7.699 1.00 1.00 O +ATOM 1595 N3 U B 50 10.096 20.425 7.779 1.00 1.00 N +ATOM 1596 C4 U B 50 8.884 21.091 7.713 1.00 1.00 C +ATOM 1597 O4 U B 50 8.830 22.310 7.865 1.00 1.00 O +ATOM 1598 C5 U B 50 7.752 20.229 7.456 1.00 1.00 C +ATOM 1599 C6 U B 50 7.916 18.893 7.301 1.00 1.00 C +ATOM 1600 H5' U B 50 12.273 16.097 4.816 1.00 1.00 H +ATOM 1601 H5'' U B 50 11.571 14.599 4.174 1.00 1.00 H +ATOM 1602 H4' U B 50 11.001 14.599 6.466 1.00 1.00 H +ATOM 1603 H3' U B 50 8.839 14.988 4.598 1.00 1.00 H +ATOM 1604 H2' U B 50 7.998 16.927 5.531 1.00 1.00 H +ATOM 1605 HO2' U B 50 7.058 16.344 7.787 1.00 1.00 H +ATOM 1606 H1' U B 50 9.271 16.380 8.201 1.00 1.00 H +ATOM 1607 H3 U B 50 10.917 20.986 7.957 1.00 1.00 H +ATOM 1608 H5 U B 50 6.754 20.660 7.387 1.00 1.00 H +ATOM 1609 H6 U B 50 7.044 18.267 7.109 1.00 1.00 H +ATOM 1610 P G B 51 7.487 12.959 5.858 1.00 1.00 P +ATOM 1611 OP1 G B 51 7.102 12.052 6.961 1.00 1.00 O +ATOM 1612 OP2 G B 51 7.808 12.404 4.524 1.00 1.00 O +ATOM 1613 O5' G B 51 6.320 14.057 5.678 1.00 1.00 O +ATOM 1614 C5' G B 51 5.262 14.160 6.637 1.00 1.00 C +ATOM 1615 C4' G B 51 3.895 14.137 5.961 1.00 1.00 C +ATOM 1616 O4' G B 51 3.568 15.442 5.475 1.00 1.00 O +ATOM 1617 C3' G B 51 3.827 13.191 4.778 1.00 1.00 C +ATOM 1618 O3' G B 51 3.266 11.943 5.192 1.00 1.00 O +ATOM 1619 C2' G B 51 2.893 13.876 3.793 1.00 1.00 C +ATOM 1620 O2' G B 51 1.563 13.357 3.885 1.00 1.00 O +ATOM 1621 C1' G B 51 2.944 15.344 4.185 1.00 1.00 C +ATOM 1622 N9 G B 51 3.723 16.172 3.245 1.00 1.00 N +ATOM 1623 C8 G B 51 5.005 16.637 3.383 1.00 1.00 C +ATOM 1624 N7 G B 51 5.419 17.354 2.377 1.00 1.00 N +ATOM 1625 C5 G B 51 4.333 17.369 1.506 1.00 1.00 C +ATOM 1626 C6 G B 51 4.193 17.995 0.236 1.00 1.00 C +ATOM 1627 O6 G B 51 5.016 18.671 -0.376 1.00 1.00 O +ATOM 1628 N1 G B 51 2.938 17.762 -0.310 1.00 1.00 N +ATOM 1629 C2 G B 51 1.941 17.021 0.286 1.00 1.00 C +ATOM 1630 N2 G B 51 0.802 16.910 -0.396 1.00 1.00 N +ATOM 1631 N3 G B 51 2.070 16.431 1.480 1.00 1.00 N +ATOM 1632 C4 G B 51 3.290 16.647 2.028 1.00 1.00 C +ATOM 1633 H5' G B 51 5.371 15.093 7.190 1.00 1.00 H +ATOM 1634 H5'' G B 51 5.329 13.324 7.331 1.00 1.00 H +ATOM 1635 H4' G B 51 3.144 13.841 6.694 1.00 1.00 H +ATOM 1636 H3' G B 51 4.816 13.052 4.339 1.00 1.00 H +ATOM 1637 H2' G B 51 3.282 13.762 2.781 1.00 1.00 H +ATOM 1638 HO2' G B 51 1.470 12.690 3.203 1.00 1.00 H +ATOM 1639 H1' G B 51 1.930 15.733 4.246 1.00 1.00 H +ATOM 1640 H8 G B 51 5.622 16.427 4.256 1.00 1.00 H +ATOM 1641 H1 G B 51 2.764 18.178 -1.213 1.00 1.00 H +ATOM 1642 H21 G B 51 0.710 17.360 -1.300 1.00 1.00 H +ATOM 1643 H22 G B 51 0.039 16.384 -0.018 1.00 1.00 H +ATOM 1644 P G B 52 3.293 10.676 4.203 1.00 1.00 P +ATOM 1645 OP1 G B 52 2.593 9.553 4.866 1.00 1.00 O +ATOM 1646 OP2 G B 52 4.678 10.497 3.714 1.00 1.00 O +ATOM 1647 O5' G B 52 2.383 11.188 2.979 1.00 1.00 O +ATOM 1648 C5' G B 52 2.878 11.146 1.640 1.00 1.00 C +ATOM 1649 C4' G B 52 1.773 11.410 0.621 1.00 1.00 C +ATOM 1650 O4' G B 52 1.554 12.823 0.477 1.00 1.00 O +ATOM 1651 C3' G B 52 2.093 10.858 -0.760 1.00 1.00 C +ATOM 1652 O3' G B 52 1.515 9.556 -0.900 1.00 1.00 O +ATOM 1653 C2' G B 52 1.415 11.832 -1.704 1.00 1.00 C +ATOM 1654 O2' G B 52 0.087 11.407 -2.029 1.00 1.00 O +ATOM 1655 C1' G B 52 1.404 13.136 -0.915 1.00 1.00 C +ATOM 1656 N9 G B 52 2.484 14.064 -1.294 1.00 1.00 N +ATOM 1657 C8 G B 52 3.477 14.604 -0.515 1.00 1.00 C +ATOM 1658 N7 G B 52 4.278 15.404 -1.162 1.00 1.00 N +ATOM 1659 C5 G B 52 3.783 15.395 -2.463 1.00 1.00 C +ATOM 1660 C6 G B 52 4.247 16.082 -3.619 1.00 1.00 C +ATOM 1661 O6 G B 52 5.204 16.846 -3.721 1.00 1.00 O +ATOM 1662 N1 G B 52 3.461 15.798 -4.730 1.00 1.00 N +ATOM 1663 C2 G B 52 2.368 14.958 -4.731 1.00 1.00 C +ATOM 1664 N2 G B 52 1.738 14.810 -5.895 1.00 1.00 N +ATOM 1665 N3 G B 52 1.931 14.311 -3.645 1.00 1.00 N +ATOM 1666 C4 G B 52 2.684 14.578 -2.552 1.00 1.00 C +ATOM 1667 H5' G B 52 3.306 10.161 1.451 1.00 1.00 H +ATOM 1668 H5'' G B 52 3.658 11.899 1.524 1.00 1.00 H +ATOM 1669 H4' G B 52 0.853 10.952 0.977 1.00 1.00 H +ATOM 1670 H3' G B 52 3.171 10.838 -0.931 1.00 1.00 H +ATOM 1671 H2' G B 52 2.013 11.954 -2.607 1.00 1.00 H +ATOM 1672 HO2' G B 52 -0.058 11.608 -2.956 1.00 1.00 H +ATOM 1673 H1' G B 52 0.447 13.633 -1.065 1.00 1.00 H +ATOM 1674 H8 G B 52 3.585 14.386 0.547 1.00 1.00 H +ATOM 1675 H1 G B 52 3.729 16.251 -5.591 1.00 1.00 H +ATOM 1676 H21 G B 52 2.069 15.298 -6.714 1.00 1.00 H +ATOM 1677 H22 G B 52 0.929 14.208 -5.960 1.00 1.00 H +ATOM 1678 P A B 53 2.369 8.339 -1.520 1.00 1.00 P +ATOM 1679 OP1 A B 53 1.667 7.074 -1.208 1.00 1.00 O +ATOM 1680 OP2 A B 53 3.784 8.514 -1.118 1.00 1.00 O +ATOM 1681 O5' A B 53 2.262 8.598 -3.105 1.00 1.00 O +ATOM 1682 C5' A B 53 1.007 8.470 -3.781 1.00 1.00 C +ATOM 1683 C4' A B 53 1.074 9.037 -5.194 1.00 1.00 C +ATOM 1684 O4' A B 53 1.280 10.442 -5.146 1.00 1.00 O +ATOM 1685 C3' A B 53 2.201 8.471 -6.041 1.00 1.00 C +ATOM 1686 O3' A B 53 1.757 7.291 -6.719 1.00 1.00 O +ATOM 1687 C2' A B 53 2.474 9.582 -7.043 1.00 1.00 C +ATOM 1688 O2' A B 53 1.746 9.382 -8.259 1.00 1.00 O +ATOM 1689 C1' A B 53 2.010 10.845 -6.312 1.00 1.00 C +ATOM 1690 N9 A B 53 3.114 11.713 -5.866 1.00 1.00 N +ATOM 1691 C8 A B 53 3.810 11.684 -4.684 1.00 1.00 C +ATOM 1692 N7 A B 53 4.731 12.604 -4.592 1.00 1.00 N +ATOM 1693 C5 A B 53 4.638 13.290 -5.800 1.00 1.00 C +ATOM 1694 C6 A B 53 5.345 14.384 -6.327 1.00 1.00 C +ATOM 1695 N6 A B 53 6.327 15.003 -5.672 1.00 1.00 N +ATOM 1696 N1 A B 53 4.997 14.810 -7.554 1.00 1.00 N +ATOM 1697 C2 A B 53 4.018 14.189 -8.200 1.00 1.00 C +ATOM 1698 N3 A B 53 3.283 13.157 -7.814 1.00 1.00 N +ATOM 1699 C4 A B 53 3.655 12.753 -6.581 1.00 1.00 C +ATOM 1700 H5' A B 53 0.242 9.007 -3.218 1.00 1.00 H +ATOM 1701 H5'' A B 53 0.736 7.416 -3.834 1.00 1.00 H +ATOM 1702 H4' A B 53 0.127 8.847 -5.694 1.00 1.00 H +ATOM 1703 H3' A B 53 3.085 8.272 -5.430 1.00 1.00 H +ATOM 1704 H2' A B 53 3.547 9.647 -7.241 1.00 1.00 H +ATOM 1705 HO2' A B 53 1.026 10.017 -8.269 1.00 1.00 H +ATOM 1706 H1' A B 53 1.353 11.416 -6.963 1.00 1.00 H +ATOM 1707 H8 A B 53 3.612 10.959 -3.894 1.00 1.00 H +ATOM 1708 H61 A B 53 6.802 15.786 -6.097 1.00 1.00 H +ATOM 1709 H62 A B 53 6.595 14.690 -4.750 1.00 1.00 H +ATOM 1710 H2 A B 53 3.786 14.584 -9.190 1.00 1.00 H +ATOM 1711 P A B 54 2.811 6.157 -7.165 1.00 1.00 P +ATOM 1712 OP1 A B 54 2.060 5.045 -7.789 1.00 1.00 O +ATOM 1713 OP2 A B 54 3.711 5.888 -6.023 1.00 1.00 O +ATOM 1714 O5' A B 54 3.662 6.898 -8.315 1.00 1.00 O +ATOM 1715 C5' A B 54 3.064 7.217 -9.577 1.00 1.00 C +ATOM 1716 C4' A B 54 4.037 7.973 -10.477 1.00 1.00 C +ATOM 1717 O4' A B 54 4.315 9.257 -9.931 1.00 1.00 O +ATOM 1718 C3' A B 54 5.385 7.293 -10.652 1.00 1.00 C +ATOM 1719 O3' A B 54 5.342 6.371 -11.749 1.00 1.00 O +ATOM 1720 C2' A B 54 6.315 8.447 -10.976 1.00 1.00 C +ATOM 1721 O2' A B 54 6.446 8.634 -12.389 1.00 1.00 O +ATOM 1722 C1' A B 54 5.641 9.647 -10.311 1.00 1.00 C +ATOM 1723 N9 A B 54 6.341 10.105 -9.101 1.00 1.00 N +ATOM 1724 C8 A B 54 6.252 9.621 -7.820 1.00 1.00 C +ATOM 1725 N7 A B 54 7.026 10.235 -6.970 1.00 1.00 N +ATOM 1726 C5 A B 54 7.674 11.195 -7.742 1.00 1.00 C +ATOM 1727 C6 A B 54 8.631 12.174 -7.432 1.00 1.00 C +ATOM 1728 N6 A B 54 9.124 12.349 -6.205 1.00 1.00 N +ATOM 1729 N1 A B 54 9.058 12.959 -8.435 1.00 1.00 N +ATOM 1730 C2 A B 54 8.566 12.775 -9.655 1.00 1.00 C +ATOM 1731 N3 A B 54 7.670 11.893 -10.070 1.00 1.00 N +ATOM 1732 C4 A B 54 7.260 11.122 -9.041 1.00 1.00 C +ATOM 1733 H5' A B 54 2.180 7.834 -9.408 1.00 1.00 H +ATOM 1734 H5'' A B 54 2.767 6.295 -10.073 1.00 1.00 H +ATOM 1735 H4' A B 54 3.577 8.108 -11.455 1.00 1.00 H +ATOM 1736 H3' A B 54 5.692 6.800 -9.727 1.00 1.00 H +ATOM 1737 H2' A B 54 7.285 8.275 -10.516 1.00 1.00 H +ATOM 1738 HO2' A B 54 7.336 8.373 -12.631 1.00 1.00 H +ATOM 1739 H1' A B 54 5.584 10.469 -11.022 1.00 1.00 H +ATOM 1740 H8 A B 54 5.596 8.797 -7.539 1.00 1.00 H +ATOM 1741 H61 A B 54 9.812 13.070 -6.035 1.00 1.00 H +ATOM 1742 H62 A B 54 8.811 11.764 -5.449 1.00 1.00 H +ATOM 1743 H2 A B 54 8.957 13.444 -10.422 1.00 1.00 H +ATOM 1744 P G B 55 6.379 5.138 -11.817 1.00 1.00 P +ATOM 1745 OP1 G B 55 5.812 4.101 -12.709 1.00 1.00 O +ATOM 1746 OP2 G B 55 6.765 4.786 -10.433 1.00 1.00 O +ATOM 1747 O5' G B 55 7.664 5.782 -12.550 1.00 1.00 O +ATOM 1748 C5' G B 55 7.709 5.907 -13.977 1.00 1.00 C +ATOM 1749 C4' G B 55 8.959 6.655 -14.438 1.00 1.00 C +ATOM 1750 O4' G B 55 9.006 7.939 -13.818 1.00 1.00 O +ATOM 1751 C3' G B 55 10.273 5.957 -14.106 1.00 1.00 C +ATOM 1752 O3' G B 55 10.672 5.136 -15.209 1.00 1.00 O +ATOM 1753 C2' G B 55 11.246 7.114 -13.934 1.00 1.00 C +ATOM 1754 O2' G B 55 11.874 7.470 -15.170 1.00 1.00 O +ATOM 1755 C1' G B 55 10.354 8.231 -13.420 1.00 1.00 C +ATOM 1756 N9 G B 55 10.364 8.350 -11.959 1.00 1.00 N +ATOM 1757 C8 G B 55 9.637 7.644 -11.036 1.00 1.00 C +ATOM 1758 N7 G B 55 9.856 8.004 -9.803 1.00 1.00 N +ATOM 1759 C5 G B 55 10.800 9.022 -9.913 1.00 1.00 C +ATOM 1760 C6 G B 55 11.424 9.800 -8.900 1.00 1.00 C +ATOM 1761 O6 G B 55 11.260 9.743 -7.683 1.00 1.00 O +ATOM 1762 N1 G B 55 12.316 10.716 -9.439 1.00 1.00 N +ATOM 1763 C2 G B 55 12.578 10.869 -10.783 1.00 1.00 C +ATOM 1764 N2 G B 55 13.472 11.801 -11.107 1.00 1.00 N +ATOM 1765 N3 G B 55 11.991 10.140 -11.739 1.00 1.00 N +ATOM 1766 C4 G B 55 11.118 9.239 -11.231 1.00 1.00 C +ATOM 1767 H5' G B 55 6.828 6.453 -14.313 1.00 1.00 H +ATOM 1768 H5'' G B 55 7.703 4.912 -14.423 1.00 1.00 H +ATOM 1769 H4' G B 55 8.901 6.799 -15.513 1.00 1.00 H +ATOM 1770 H3' G B 55 10.186 5.379 -13.183 1.00 1.00 H +ATOM 1771 H2' G B 55 11.990 6.873 -13.174 1.00 1.00 H +ATOM 1772 HO2' G B 55 12.797 7.656 -14.976 1.00 1.00 H +ATOM 1773 H1' G B 55 10.663 9.181 -13.857 1.00 1.00 H +ATOM 1774 H8 G B 55 8.939 6.853 -11.308 1.00 1.00 H +ATOM 1775 H1 G B 55 12.799 11.308 -8.778 1.00 1.00 H +ATOM 1776 H21 G B 55 13.916 12.351 -10.385 1.00 1.00 H +ATOM 1777 H22 G B 55 13.706 11.959 -12.077 1.00 1.00 H +ATOM 1778 P A B 56 11.560 3.811 -14.973 1.00 1.00 P +ATOM 1779 OP1 A B 56 11.757 3.150 -16.282 1.00 1.00 O +ATOM 1780 OP2 A B 56 10.972 3.053 -13.846 1.00 1.00 O +ATOM 1781 O5' A B 56 12.977 4.409 -14.496 1.00 1.00 O +ATOM 1782 C5' A B 56 13.810 5.132 -15.407 1.00 1.00 C +ATOM 1783 C4' A B 56 14.983 5.788 -14.686 1.00 1.00 C +ATOM 1784 O4' A B 56 14.511 6.781 -13.781 1.00 1.00 O +ATOM 1785 C3' A B 56 15.813 4.830 -13.851 1.00 1.00 C +ATOM 1786 O3' A B 56 16.837 4.227 -14.650 1.00 1.00 O +ATOM 1787 C2' A B 56 16.428 5.734 -12.799 1.00 1.00 C +ATOM 1788 O2' A B 56 17.724 6.200 -13.186 1.00 1.00 O +ATOM 1789 C1' A B 56 15.431 6.881 -12.684 1.00 1.00 C +ATOM 1790 N9 A B 56 14.658 6.836 -11.436 1.00 1.00 N +ATOM 1791 C8 A B 56 13.523 6.122 -11.146 1.00 1.00 C +ATOM 1792 N7 A B 56 13.069 6.321 -9.939 1.00 1.00 N +ATOM 1793 C5 A B 56 13.967 7.233 -9.392 1.00 1.00 C +ATOM 1794 C6 A B 56 14.045 7.850 -8.133 1.00 1.00 C +ATOM 1795 N6 A B 56 13.165 7.626 -7.155 1.00 1.00 N +ATOM 1796 N1 A B 56 15.064 8.701 -7.924 1.00 1.00 N +ATOM 1797 C2 A B 56 15.937 8.917 -8.901 1.00 1.00 C +ATOM 1798 N3 A B 56 15.973 8.401 -10.121 1.00 1.00 N +ATOM 1799 C4 A B 56 14.938 7.553 -10.298 1.00 1.00 C +ATOM 1800 H5' A B 56 13.217 5.903 -15.902 1.00 1.00 H +ATOM 1801 H5'' A B 56 14.196 4.443 -16.159 1.00 1.00 H +ATOM 1802 H4' A B 56 15.623 6.269 -15.423 1.00 1.00 H +ATOM 1803 H3' A B 56 15.176 4.076 -13.384 1.00 1.00 H +ATOM 1804 H2' A B 56 16.474 5.208 -11.851 1.00 1.00 H +ATOM 1805 HO2' A B 56 18.257 6.251 -12.387 1.00 1.00 H +ATOM 1806 H1' A B 56 15.958 7.833 -12.739 1.00 1.00 H +ATOM 1807 H8 A B 56 13.044 5.449 -11.857 1.00 1.00 H +ATOM 1808 H61 A B 56 13.269 8.097 -6.267 1.00 1.00 H +ATOM 1809 H62 A B 56 12.398 6.989 -7.304 1.00 1.00 H +ATOM 1810 H2 A B 56 16.739 9.618 -8.665 1.00 1.00 H +ATOM 1811 P A B 57 17.426 2.776 -14.267 1.00 1.00 P +ATOM 1812 OP1 A B 57 18.062 2.201 -15.473 1.00 1.00 O +ATOM 1813 OP2 A B 57 16.366 2.020 -13.565 1.00 1.00 O +ATOM 1814 O5' A B 57 18.588 3.118 -13.203 1.00 1.00 O +ATOM 1815 C5' A B 57 19.890 3.526 -13.641 1.00 1.00 C +ATOM 1816 C4' A B 57 20.830 3.755 -12.461 1.00 1.00 C +ATOM 1817 O4' A B 57 20.353 4.848 -11.684 1.00 1.00 O +ATOM 1818 C3' A B 57 20.960 2.568 -11.515 1.00 1.00 C +ATOM 1819 O3' A B 57 22.073 1.753 -11.901 1.00 1.00 O +ATOM 1820 C2' A B 57 21.234 3.227 -10.175 1.00 1.00 C +ATOM 1821 O2' A B 57 22.633 3.454 -9.975 1.00 1.00 O +ATOM 1822 C1' A B 57 20.460 4.535 -10.287 1.00 1.00 C +ATOM 1823 N9 A B 57 19.094 4.451 -9.759 1.00 1.00 N +ATOM 1824 C8 A B 57 17.973 3.949 -10.367 1.00 1.00 C +ATOM 1825 N7 A B 57 16.893 4.039 -9.641 1.00 1.00 N +ATOM 1826 C5 A B 57 17.331 4.645 -8.467 1.00 1.00 C +ATOM 1827 C6 A B 57 16.667 5.020 -7.287 1.00 1.00 C +ATOM 1828 N6 A B 57 15.360 4.831 -7.093 1.00 1.00 N +ATOM 1829 N1 A B 57 17.402 5.596 -6.322 1.00 1.00 N +ATOM 1830 C2 A B 57 18.702 5.783 -6.521 1.00 1.00 C +ATOM 1831 N3 A B 57 19.438 5.475 -7.580 1.00 1.00 N +ATOM 1832 C4 A B 57 18.671 4.899 -8.530 1.00 1.00 C +ATOM 1833 H5' A B 57 19.801 4.454 -14.204 1.00 1.00 H +ATOM 1834 H5'' A B 57 20.311 2.756 -14.289 1.00 1.00 H +ATOM 1835 H4' A B 57 21.814 4.014 -12.842 1.00 1.00 H +ATOM 1836 H3' A B 57 20.032 1.991 -11.483 1.00 1.00 H +ATOM 1837 H2' A B 57 20.818 2.623 -9.373 1.00 1.00 H +ATOM 1838 HO2' A B 57 22.723 4.062 -9.239 1.00 1.00 H +ATOM 1839 H1' A B 57 20.995 5.334 -9.772 1.00 1.00 H +ATOM 1840 H8 A B 57 17.982 3.511 -11.366 1.00 1.00 H +ATOM 1841 H61 A B 57 14.933 5.121 -6.222 1.00 1.00 H +ATOM 1842 H62 A B 57 14.801 4.400 -7.813 1.00 1.00 H +ATOM 1843 H2 A B 57 19.239 6.254 -5.697 1.00 1.00 H +ATOM 1844 P C B 58 22.118 0.191 -11.505 1.00 1.00 P +ATOM 1845 OP1 C B 58 23.436 -0.349 -11.905 1.00 1.00 O +ATOM 1846 OP2 C B 58 20.878 -0.451 -11.997 1.00 1.00 O +ATOM 1847 O5' C B 58 22.059 0.228 -9.895 1.00 1.00 O +ATOM 1848 C5' C B 58 23.230 0.520 -9.128 1.00 1.00 C +ATOM 1849 C4' C B 58 22.894 0.746 -7.654 1.00 1.00 C +ATOM 1850 O4' C B 58 21.919 1.773 -7.525 1.00 1.00 O +ATOM 1851 C3' C B 58 22.308 -0.460 -6.944 1.00 1.00 C +ATOM 1852 O3' C B 58 23.358 -1.287 -6.424 1.00 1.00 O +ATOM 1853 C2' C B 58 21.527 0.166 -5.795 1.00 1.00 C +ATOM 1854 O2' C B 58 22.309 0.218 -4.597 1.00 1.00 O +ATOM 1855 C1' C B 58 21.192 1.572 -6.302 1.00 1.00 C +ATOM 1856 N1 C B 58 19.758 1.774 -6.594 1.00 1.00 N +ATOM 1857 C2 C B 58 18.982 2.414 -5.639 1.00 1.00 C +ATOM 1858 O2 C B 58 19.494 2.807 -4.592 1.00 1.00 O +ATOM 1859 N3 C B 58 17.657 2.592 -5.897 1.00 1.00 N +ATOM 1860 C4 C B 58 17.115 2.160 -7.045 1.00 1.00 C +ATOM 1861 N4 C B 58 15.815 2.347 -7.267 1.00 1.00 N +ATOM 1862 C5 C B 58 17.914 1.502 -8.033 1.00 1.00 C +ATOM 1863 C6 C B 58 19.222 1.331 -7.768 1.00 1.00 C +ATOM 1864 H5' C B 58 23.705 1.418 -9.528 1.00 1.00 H +ATOM 1865 H5'' C B 58 23.925 -0.314 -9.209 1.00 1.00 H +ATOM 1866 H4' C B 58 23.797 1.062 -7.134 1.00 1.00 H +ATOM 1867 H3' C B 58 21.647 -1.022 -7.607 1.00 1.00 H +ATOM 1868 H2' C B 58 20.607 -0.396 -5.627 1.00 1.00 H +ATOM 1869 HO2' C B 58 21.882 0.843 -4.007 1.00 1.00 H +ATOM 1870 H1' C B 58 21.517 2.301 -5.568 1.00 1.00 H +ATOM 1871 H41 C B 58 15.252 2.810 -6.575 1.00 1.00 H +ATOM 1872 H42 C B 58 15.397 2.026 -8.127 1.00 1.00 H +ATOM 1873 H5 C B 58 17.478 1.153 -8.969 1.00 1.00 H +ATOM 1874 H6 C B 58 19.862 0.835 -8.500 1.00 1.00 H +ATOM 1875 P C B 59 23.078 -2.837 -6.072 1.00 1.00 P +ATOM 1876 OP1 C B 59 24.309 -3.411 -5.483 1.00 1.00 O +ATOM 1877 OP2 C B 59 22.459 -3.475 -7.255 1.00 1.00 O +ATOM 1878 O5' C B 59 21.965 -2.734 -4.913 1.00 1.00 O +ATOM 1879 C5' C B 59 22.299 -2.179 -3.639 1.00 1.00 C +ATOM 1880 C4' C B 59 21.060 -1.696 -2.883 1.00 1.00 C +ATOM 1881 O4' C B 59 20.285 -0.845 -3.717 1.00 1.00 O +ATOM 1882 C3' C B 59 20.114 -2.793 -2.426 1.00 1.00 C +ATOM 1883 O3' C B 59 20.484 -3.222 -1.111 1.00 1.00 O +ATOM 1884 C2' C B 59 18.761 -2.094 -2.359 1.00 1.00 C +ATOM 1885 O2' C B 59 18.441 -1.701 -1.021 1.00 1.00 O +ATOM 1886 C1' C B 59 18.921 -0.879 -3.277 1.00 1.00 C +ATOM 1887 N1 C B 59 18.033 -0.894 -4.463 1.00 1.00 N +ATOM 1888 C2 C B 59 16.874 -0.138 -4.388 1.00 1.00 C +ATOM 1889 O2 C B 59 16.617 0.495 -3.366 1.00 1.00 O +ATOM 1890 N3 C B 59 16.041 -0.123 -5.464 1.00 1.00 N +ATOM 1891 C4 C B 59 16.332 -0.822 -6.569 1.00 1.00 C +ATOM 1892 N4 C B 59 15.494 -0.785 -7.604 1.00 1.00 N +ATOM 1893 C5 C B 59 17.526 -1.606 -6.651 1.00 1.00 C +ATOM 1894 C6 C B 59 18.345 -1.613 -5.581 1.00 1.00 C +ATOM 1895 H5' C B 59 22.977 -1.337 -3.785 1.00 1.00 H +ATOM 1896 H5'' C B 59 22.802 -2.939 -3.043 1.00 1.00 H +ATOM 1897 H4' C B 59 21.382 -1.124 -2.016 1.00 1.00 H +ATOM 1898 H3' C B 59 20.098 -3.624 -3.133 1.00 1.00 H +ATOM 1899 H2' C B 59 17.991 -2.759 -2.763 1.00 1.00 H +ATOM 1900 HO2' C B 59 18.567 -0.752 -0.966 1.00 1.00 H +ATOM 1901 H1' C B 59 18.724 0.022 -2.696 1.00 1.00 H +ATOM 1902 H41 C B 59 14.647 -0.234 -7.550 1.00 1.00 H +ATOM 1903 H42 C B 59 15.703 -1.309 -8.442 1.00 1.00 H +ATOM 1904 H5 C B 59 17.766 -2.175 -7.550 1.00 1.00 H +ATOM 1905 H6 C B 59 19.262 -2.201 -5.608 1.00 1.00 H +ATOM 1906 P G B 60 19.776 -4.499 -0.433 1.00 1.00 P +ATOM 1907 OP1 G B 60 20.697 -5.054 0.583 1.00 1.00 O +ATOM 1908 OP2 G B 60 19.260 -5.369 -1.512 1.00 1.00 O +ATOM 1909 O5' G B 60 18.515 -3.847 0.335 1.00 1.00 O +ATOM 1910 C5' G B 60 18.703 -3.017 1.489 1.00 1.00 C +ATOM 1911 C4' G B 60 17.371 -2.596 2.107 1.00 1.00 C +ATOM 1912 O4' G B 60 16.662 -1.740 1.216 1.00 1.00 O +ATOM 1913 C3' G B 60 16.438 -3.753 2.424 1.00 1.00 C +ATOM 1914 O3' G B 60 16.663 -4.210 3.761 1.00 1.00 O +ATOM 1915 C2' G B 60 15.052 -3.144 2.311 1.00 1.00 C +ATOM 1916 O2' G B 60 14.563 -2.703 3.580 1.00 1.00 O +ATOM 1917 C1' G B 60 15.252 -1.970 1.360 1.00 1.00 C +ATOM 1918 N9 G B 60 14.712 -2.210 0.019 1.00 1.00 N +ATOM 1919 C8 G B 60 15.389 -2.553 -1.122 1.00 1.00 C +ATOM 1920 N7 G B 60 14.623 -2.707 -2.165 1.00 1.00 N +ATOM 1921 C5 G B 60 13.344 -2.446 -1.684 1.00 1.00 C +ATOM 1922 C6 G B 60 12.095 -2.459 -2.364 1.00 1.00 C +ATOM 1923 O6 G B 60 11.871 -2.708 -3.546 1.00 1.00 O +ATOM 1924 N1 G B 60 11.048 -2.139 -1.509 1.00 1.00 N +ATOM 1925 C2 G B 60 11.181 -1.843 -0.170 1.00 1.00 C +ATOM 1926 N2 G B 60 10.056 -1.562 0.486 1.00 1.00 N +ATOM 1927 N3 G B 60 12.355 -1.831 0.471 1.00 1.00 N +ATOM 1928 C4 G B 60 13.389 -2.140 -0.347 1.00 1.00 C +ATOM 1929 H5' G B 60 19.257 -2.124 1.199 1.00 1.00 H +ATOM 1930 H5'' G B 60 19.280 -3.567 2.231 1.00 1.00 H +ATOM 1931 H4' G B 60 17.570 -2.045 3.024 1.00 1.00 H +ATOM 1932 H3' G B 60 16.565 -4.563 1.702 1.00 1.00 H +ATOM 1933 H2' G B 60 14.365 -3.869 1.864 1.00 1.00 H +ATOM 1934 HO2' G B 60 13.742 -2.233 3.421 1.00 1.00 H +ATOM 1935 H1' G B 60 14.782 -1.081 1.778 1.00 1.00 H +ATOM 1936 H8 G B 60 16.470 -2.688 -1.154 1.00 1.00 H +ATOM 1937 H1 G B 60 10.126 -2.128 -1.922 1.00 1.00 H +ATOM 1938 H21 G B 60 9.171 -1.573 0.000 1.00 1.00 H +ATOM 1939 H22 G B 60 10.088 -1.338 1.470 1.00 1.00 H +ATOM 1940 P G B 61 16.170 -5.673 4.218 1.00 1.00 P +ATOM 1941 OP1 G B 61 16.625 -5.902 5.608 1.00 1.00 O +ATOM 1942 OP2 G B 61 16.532 -6.637 3.155 1.00 1.00 O +ATOM 1943 O5' G B 61 14.565 -5.517 4.234 1.00 1.00 O +ATOM 1944 C5' G B 61 13.929 -4.614 5.144 1.00 1.00 C +ATOM 1945 C4' G B 61 12.411 -4.628 4.987 1.00 1.00 C +ATOM 1946 O4' G B 61 12.046 -4.134 3.702 1.00 1.00 O +ATOM 1947 C3' G B 61 11.785 -6.007 5.109 1.00 1.00 C +ATOM 1948 O3' G B 61 11.427 -6.255 6.474 1.00 1.00 O +ATOM 1949 C2' G B 61 10.533 -5.914 4.253 1.00 1.00 C +ATOM 1950 O2' G B 61 9.380 -5.619 5.047 1.00 1.00 O +ATOM 1951 C1' G B 61 10.837 -4.778 3.277 1.00 1.00 C +ATOM 1952 N9 G B 61 11.037 -5.227 1.888 1.00 1.00 N +ATOM 1953 C8 G B 61 12.180 -5.697 1.296 1.00 1.00 C +ATOM 1954 N7 G B 61 12.031 -6.020 0.042 1.00 1.00 N +ATOM 1955 C5 G B 61 10.693 -5.743 -0.221 1.00 1.00 C +ATOM 1956 C6 G B 61 9.950 -5.896 -1.424 1.00 1.00 C +ATOM 1957 O6 G B 61 10.337 -6.314 -2.513 1.00 1.00 O +ATOM 1958 N1 G B 61 8.628 -5.502 -1.260 1.00 1.00 N +ATOM 1959 C2 G B 61 8.086 -5.022 -0.088 1.00 1.00 C +ATOM 1960 N2 G B 61 6.795 -4.694 -0.128 1.00 1.00 N +ATOM 1961 N3 G B 61 8.782 -4.877 1.045 1.00 1.00 N +ATOM 1962 C4 G B 61 10.074 -5.258 0.905 1.00 1.00 C +ATOM 1963 H5' G B 61 14.296 -3.603 4.958 1.00 1.00 H +ATOM 1964 H5'' G B 61 14.183 -4.900 6.165 1.00 1.00 H +ATOM 1965 H4' G B 61 11.975 -3.975 5.741 1.00 1.00 H +ATOM 1966 H3' G B 61 12.460 -6.775 4.729 1.00 1.00 H +ATOM 1967 H2' G B 61 10.394 -6.846 3.701 1.00 1.00 H +ATOM 1968 HO2' G B 61 8.666 -6.175 4.729 1.00 1.00 H +ATOM 1969 H1' G B 61 10.021 -4.057 3.301 1.00 1.00 H +ATOM 1970 H8 G B 61 13.128 -5.791 1.825 1.00 1.00 H +ATOM 1971 H1 G B 61 8.037 -5.582 -2.076 1.00 1.00 H +ATOM 1972 H21 G B 61 6.272 -4.803 -0.984 1.00 1.00 H +ATOM 1973 H22 G B 61 6.340 -4.336 0.700 1.00 1.00 H +ATOM 1974 P G B 62 10.979 -7.727 6.951 1.00 1.00 P +ATOM 1975 OP1 G B 62 11.005 -7.763 8.430 1.00 1.00 O +ATOM 1976 OP2 G B 62 11.757 -8.719 6.175 1.00 1.00 O +ATOM 1977 O5' G B 62 9.442 -7.802 6.470 1.00 1.00 O +ATOM 1978 C5' G B 62 8.451 -6.952 7.061 1.00 1.00 C +ATOM 1979 C4' G B 62 7.134 -6.997 6.288 1.00 1.00 C +ATOM 1980 O4' G B 62 7.372 -6.701 4.915 1.00 1.00 O +ATOM 1981 C3' G B 62 6.431 -8.345 6.339 1.00 1.00 C +ATOM 1982 O3' G B 62 5.469 -8.336 7.401 1.00 1.00 O +ATOM 1983 C2' G B 62 5.721 -8.437 4.995 1.00 1.00 C +ATOM 1984 O2' G B 62 4.362 -7.991 5.090 1.00 1.00 O +ATOM 1985 C1' G B 62 6.546 -7.528 4.086 1.00 1.00 C +ATOM 1986 N9 G B 62 7.437 -8.254 3.168 1.00 1.00 N +ATOM 1987 C8 G B 62 8.688 -8.760 3.407 1.00 1.00 C +ATOM 1988 N7 G B 62 9.221 -9.358 2.377 1.00 1.00 N +ATOM 1989 C5 G B 62 8.255 -9.241 1.383 1.00 1.00 C +ATOM 1990 C6 G B 62 8.271 -9.703 0.038 1.00 1.00 C +ATOM 1991 O6 G B 62 9.159 -10.317 -0.547 1.00 1.00 O +ATOM 1992 N1 G B 62 7.096 -9.375 -0.627 1.00 1.00 N +ATOM 1993 C2 G B 62 6.037 -8.689 -0.071 1.00 1.00 C +ATOM 1994 N2 G B 62 4.993 -8.468 -0.868 1.00 1.00 N +ATOM 1995 N3 G B 62 6.021 -8.254 1.194 1.00 1.00 N +ATOM 1996 C4 G B 62 7.159 -8.565 1.858 1.00 1.00 C +ATOM 1997 H5' G B 62 8.822 -5.928 7.072 1.00 1.00 H +ATOM 1998 H5'' G B 62 8.273 -7.276 8.087 1.00 1.00 H +ATOM 1999 H4' G B 62 6.467 -6.238 6.690 1.00 1.00 H +ATOM 2000 H3' G B 62 7.150 -9.157 6.458 1.00 1.00 H +ATOM 2001 H2' G B 62 5.763 -9.464 4.625 1.00 1.00 H +ATOM 2002 HO2' G B 62 4.381 -7.053 5.297 1.00 1.00 H +ATOM 2003 H1' G B 62 5.876 -6.896 3.500 1.00 1.00 H +ATOM 2004 H8 G B 62 9.192 -8.671 4.368 1.00 1.00 H +ATOM 2005 H1 G B 62 7.034 -9.671 -1.591 1.00 1.00 H +ATOM 2006 H21 G B 62 5.009 -8.797 -1.821 1.00 1.00 H +ATOM 2007 H22 G B 62 4.188 -7.971 -0.518 1.00 1.00 H +ATOM 2008 P G B 63 5.181 -9.667 8.262 1.00 1.00 P +ATOM 2009 OP1 G B 63 4.347 -9.292 9.426 1.00 1.00 O +ATOM 2010 OP2 G B 63 6.466 -10.372 8.472 1.00 1.00 O +ATOM 2011 O5' G B 63 4.283 -10.548 7.261 1.00 1.00 O +ATOM 2012 C5' G B 63 4.351 -11.974 7.297 1.00 1.00 C +ATOM 2013 C4' G B 63 3.762 -12.597 6.034 1.00 1.00 C +ATOM 2014 O4' G B 63 4.111 -11.809 4.891 1.00 1.00 O +ATOM 2015 C3' G B 63 4.238 -14.020 5.769 1.00 1.00 C +ATOM 2016 O3' G B 63 3.262 -14.941 6.266 1.00 1.00 O +ATOM 2017 C2' G B 63 4.305 -14.102 4.252 1.00 1.00 C +ATOM 2018 O2' G B 63 3.072 -14.580 3.702 1.00 1.00 O +ATOM 2019 C1' G B 63 4.579 -12.659 3.836 1.00 1.00 C +ATOM 2020 N9 G B 63 6.007 -12.352 3.635 1.00 1.00 N +ATOM 2021 C8 G B 63 6.926 -11.942 4.566 1.00 1.00 C +ATOM 2022 N7 G B 63 8.119 -11.747 4.081 1.00 1.00 N +ATOM 2023 C5 G B 63 7.986 -12.047 2.731 1.00 1.00 C +ATOM 2024 C6 G B 63 8.957 -12.017 1.692 1.00 1.00 C +ATOM 2025 O6 G B 63 10.145 -11.714 1.767 1.00 1.00 O +ATOM 2026 N1 G B 63 8.410 -12.390 0.473 1.00 1.00 N +ATOM 2027 C2 G B 63 7.094 -12.750 0.273 1.00 1.00 C +ATOM 2028 N2 G B 63 6.758 -13.076 -0.975 1.00 1.00 N +ATOM 2029 N3 G B 63 6.178 -12.781 1.247 1.00 1.00 N +ATOM 2030 C4 G B 63 6.695 -12.419 2.446 1.00 1.00 C +ATOM 2031 H5' G B 63 3.792 -12.332 8.163 1.00 1.00 H +ATOM 2032 H5'' G B 63 5.391 -12.277 7.399 1.00 1.00 H +ATOM 2033 H4' G B 63 2.679 -12.603 6.123 1.00 1.00 H +ATOM 2034 H3' G B 63 5.219 -14.198 6.213 1.00 1.00 H +ATOM 2035 H2' G B 63 5.139 -14.742 3.949 1.00 1.00 H +ATOM 2036 HO2' G B 63 3.039 -15.528 3.855 1.00 1.00 H +ATOM 2037 H1' G B 63 4.035 -12.435 2.918 1.00 1.00 H +ATOM 2038 H8 G B 63 6.681 -11.792 5.618 1.00 1.00 H +ATOM 2039 H1 G B 63 9.041 -12.392 -0.316 1.00 1.00 H +ATOM 2040 H21 G B 63 7.451 -13.051 -1.709 1.00 1.00 H +ATOM 2041 H22 G B 63 5.812 -13.346 -1.185 1.00 1.00 H +ATOM 2042 P A B 64 3.642 -15.976 7.438 1.00 1.00 P +ATOM 2043 OP1 A B 64 2.388 -16.576 7.951 1.00 1.00 O +ATOM 2044 OP2 A B 64 4.573 -15.303 8.369 1.00 1.00 O +ATOM 2045 O5' A B 64 4.457 -17.115 6.637 1.00 1.00 O +ATOM 2046 C5' A B 64 5.400 -17.954 7.311 1.00 1.00 C +ATOM 2047 C4' A B 64 5.852 -19.118 6.426 1.00 1.00 C +ATOM 2048 O4' A B 64 4.765 -20.035 6.244 1.00 1.00 O +ATOM 2049 C3' A B 64 6.333 -18.694 5.042 1.00 1.00 C +ATOM 2050 O3' A B 64 7.762 -18.727 5.003 1.00 1.00 O +ATOM 2051 C2' A B 64 5.769 -19.753 4.102 1.00 1.00 C +ATOM 2052 O2' A B 64 6.719 -20.799 3.861 1.00 1.00 O +ATOM 2053 C1' A B 64 4.550 -20.275 4.846 1.00 1.00 C +ATOM 2054 N9 A B 64 3.289 -19.604 4.473 1.00 1.00 N +ATOM 2055 C8 A B 64 2.705 -18.519 5.071 1.00 1.00 C +ATOM 2056 N7 A B 64 1.581 -18.152 4.520 1.00 1.00 N +ATOM 2057 C5 A B 64 1.408 -19.062 3.481 1.00 1.00 C +ATOM 2058 C6 A B 64 0.402 -19.214 2.514 1.00 1.00 C +ATOM 2059 N6 A B 64 -0.661 -18.414 2.434 1.00 1.00 N +ATOM 2060 N1 A B 64 0.541 -20.221 1.635 1.00 1.00 N +ATOM 2061 C2 A B 64 1.603 -21.012 1.718 1.00 1.00 C +ATOM 2062 N3 A B 64 2.612 -20.971 2.577 1.00 1.00 N +ATOM 2063 C4 A B 64 2.444 -19.952 3.445 1.00 1.00 C +ATOM 2064 H5' A B 64 4.940 -18.353 8.213 1.00 1.00 H +ATOM 2065 H5'' A B 64 6.272 -17.359 7.590 1.00 1.00 H +ATOM 2066 H4' A B 64 6.659 -19.643 6.932 1.00 1.00 H +ATOM 2067 H3' A B 64 5.952 -17.704 4.786 1.00 1.00 H +ATOM 2068 H2' A B 64 5.460 -19.290 3.163 1.00 1.00 H +ATOM 2069 HO2' A B 64 7.526 -20.562 4.323 1.00 1.00 H +ATOM 2070 H1' A B 64 4.451 -21.346 4.675 1.00 1.00 H +ATOM 2071 H8 A B 64 3.140 -18.008 5.931 1.00 1.00 H +ATOM 2072 H61 A B 64 -1.355 -18.568 1.717 1.00 1.00 H +ATOM 2073 H62 A B 64 -0.770 -17.655 3.091 1.00 1.00 H +ATOM 2074 H2 A B 64 1.652 -21.808 0.975 1.00 1.00 H +ATOM 2075 P A B 65 8.565 -17.832 3.933 1.00 1.00 P +ATOM 2076 OP1 A B 65 9.999 -17.840 4.302 1.00 1.00 O +ATOM 2077 OP2 A B 65 7.849 -16.544 3.779 1.00 1.00 O +ATOM 2078 O5' A B 65 8.390 -18.673 2.573 1.00 1.00 O +ATOM 2079 C5' A B 65 8.026 -18.016 1.357 1.00 1.00 C +ATOM 2080 C4' A B 65 7.166 -18.917 0.476 1.00 1.00 C +ATOM 2081 O4' A B 65 5.968 -19.254 1.176 1.00 1.00 O +ATOM 2082 C3' A B 65 6.760 -18.280 -0.849 1.00 1.00 C +ATOM 2083 O3' A B 65 7.637 -18.729 -1.889 1.00 1.00 O +ATOM 2084 C2' A B 65 5.361 -18.818 -1.096 1.00 1.00 C +ATOM 2085 O2' A B 65 5.394 -20.004 -1.895 1.00 1.00 O +ATOM 2086 C1' A B 65 4.840 -19.102 0.309 1.00 1.00 C +ATOM 2087 N9 A B 65 3.999 -18.027 0.859 1.00 1.00 N +ATOM 2088 C8 A B 65 4.278 -17.150 1.877 1.00 1.00 C +ATOM 2089 N7 A B 65 3.312 -16.308 2.125 1.00 1.00 N +ATOM 2090 C5 A B 65 2.325 -16.654 1.204 1.00 1.00 C +ATOM 2091 C6 A B 65 1.044 -16.141 0.945 1.00 1.00 C +ATOM 2092 N6 A B 65 0.514 -15.120 1.621 1.00 1.00 N +ATOM 2093 N1 A B 65 0.334 -16.721 -0.039 1.00 1.00 N +ATOM 2094 C2 A B 65 0.866 -17.736 -0.709 1.00 1.00 C +ATOM 2095 N3 A B 65 2.052 -18.304 -0.560 1.00 1.00 N +ATOM 2096 C4 A B 65 2.738 -17.701 0.432 1.00 1.00 C +ATOM 2097 H5' A B 65 8.930 -17.745 0.814 1.00 1.00 H +ATOM 2098 H5'' A B 65 7.466 -17.113 1.595 1.00 1.00 H +ATOM 2099 H4' A B 65 7.715 -19.835 0.274 1.00 1.00 H +ATOM 2100 H3' A B 65 6.752 -17.191 -0.774 1.00 1.00 H +ATOM 2101 H2' A B 65 4.746 -18.051 -1.571 1.00 1.00 H +ATOM 2102 HO2' A B 65 6.125 -19.911 -2.511 1.00 1.00 H +ATOM 2103 H1' A B 65 4.268 -20.029 0.302 1.00 1.00 H +ATOM 2104 H8 A B 65 5.219 -17.155 2.428 1.00 1.00 H +ATOM 2105 H61 A B 65 -0.412 -14.790 1.394 1.00 1.00 H +ATOM 2106 H62 A B 65 1.041 -14.680 2.361 1.00 1.00 H +ATOM 2107 H2 A B 65 0.238 -18.161 -1.492 1.00 1.00 H +ATOM 2108 P A B 66 8.179 -17.702 -3.010 1.00 1.00 P +ATOM 2109 OP1 A B 66 9.089 -18.441 -3.913 1.00 1.00 O +ATOM 2110 OP2 A B 66 8.653 -16.480 -2.325 1.00 1.00 O +ATOM 2111 O5' A B 66 6.847 -17.331 -3.834 1.00 1.00 O +ATOM 2112 C5' A B 66 6.403 -18.149 -4.921 1.00 1.00 C +ATOM 2113 C4' A B 66 5.005 -17.750 -5.383 1.00 1.00 C +ATOM 2114 O4' A B 66 4.110 -17.801 -4.274 1.00 1.00 O +ATOM 2115 C3' A B 66 4.921 -16.344 -5.963 1.00 1.00 C +ATOM 2116 O3' A B 66 4.994 -16.408 -7.390 1.00 1.00 O +ATOM 2117 C2' A B 66 3.542 -15.859 -5.539 1.00 1.00 C +ATOM 2118 O2' A B 66 2.557 -16.148 -6.538 1.00 1.00 O +ATOM 2119 C1' A B 66 3.276 -16.635 -4.253 1.00 1.00 C +ATOM 2120 N9 A B 66 3.606 -15.884 -3.029 1.00 1.00 N +ATOM 2121 C8 A B 66 4.838 -15.658 -2.471 1.00 1.00 C +ATOM 2122 N7 A B 66 4.802 -14.930 -1.390 1.00 1.00 N +ATOM 2123 C5 A B 66 3.450 -14.653 -1.220 1.00 1.00 C +ATOM 2124 C6 A B 66 2.745 -13.919 -0.252 1.00 1.00 C +ATOM 2125 N6 A B 66 3.337 -13.297 0.769 1.00 1.00 N +ATOM 2126 N1 A B 66 1.410 -13.850 -0.383 1.00 1.00 N +ATOM 2127 C2 A B 66 0.827 -14.465 -1.404 1.00 1.00 C +ATOM 2128 N3 A B 66 1.376 -15.180 -2.374 1.00 1.00 N +ATOM 2129 C4 A B 66 2.714 -15.232 -2.214 1.00 1.00 C +ATOM 2130 H5' A B 66 6.387 -19.192 -4.602 1.00 1.00 H +ATOM 2131 H5'' A B 66 7.097 -18.043 -5.754 1.00 1.00 H +ATOM 2132 H4' A B 66 4.665 -18.462 -6.132 1.00 1.00 H +ATOM 2133 H3' A B 66 5.703 -15.704 -5.551 1.00 1.00 H +ATOM 2134 H2' A B 66 3.573 -14.789 -5.324 1.00 1.00 H +ATOM 2135 HO2' A B 66 2.080 -16.930 -6.251 1.00 1.00 H +ATOM 2136 H1' A B 66 2.232 -16.935 -4.220 1.00 1.00 H +ATOM 2137 H8 A B 66 5.763 -16.053 -2.892 1.00 1.00 H +ATOM 2138 H61 A B 66 2.781 -12.782 1.436 1.00 1.00 H +ATOM 2139 H62 A B 66 4.346 -13.342 0.877 1.00 1.00 H +ATOM 2140 H2 A B 66 -0.258 -14.368 -1.449 1.00 1.00 H +ATOM 2141 P C B 67 5.927 -15.383 -8.210 1.00 1.00 P +ATOM 2142 OP1 C B 67 5.753 -15.652 -9.655 1.00 1.00 O +ATOM 2143 OP2 C B 67 7.282 -15.413 -7.614 1.00 1.00 O +ATOM 2144 O5' C B 67 5.260 -13.957 -7.879 1.00 1.00 O +ATOM 2145 C5' C B 67 3.880 -13.716 -8.162 1.00 1.00 C +ATOM 2146 C4' C B 67 3.347 -12.524 -7.372 1.00 1.00 C +ATOM 2147 O4' C B 67 3.587 -12.725 -5.979 1.00 1.00 O +ATOM 2148 C3' C B 67 3.990 -11.195 -7.736 1.00 1.00 C +ATOM 2149 O3' C B 67 3.219 -10.541 -8.750 1.00 1.00 O +ATOM 2150 C2' C B 67 3.917 -10.401 -6.444 1.00 1.00 C +ATOM 2151 O2' C B 67 2.717 -9.626 -6.370 1.00 1.00 O +ATOM 2152 C1' C B 67 3.943 -11.476 -5.368 1.00 1.00 C +ATOM 2153 N1 C B 67 5.267 -11.647 -4.745 1.00 1.00 N +ATOM 2154 C2 C B 67 5.518 -10.965 -3.566 1.00 1.00 C +ATOM 2155 O2 C B 67 4.650 -10.245 -3.075 1.00 1.00 O +ATOM 2156 N3 C B 67 6.737 -11.114 -2.980 1.00 1.00 N +ATOM 2157 C4 C B 67 7.673 -11.901 -3.529 1.00 1.00 C +ATOM 2158 N4 C B 67 8.857 -12.025 -2.930 1.00 1.00 N +ATOM 2159 C5 C B 67 7.418 -12.607 -4.747 1.00 1.00 C +ATOM 2160 C6 C B 67 6.208 -12.453 -5.318 1.00 1.00 C +ATOM 2161 H5' C B 67 3.302 -14.602 -7.900 1.00 1.00 H +ATOM 2162 H5'' C B 67 3.764 -13.518 -9.228 1.00 1.00 H +ATOM 2163 H4' C B 67 2.273 -12.452 -7.526 1.00 1.00 H +ATOM 2164 H3' C B 67 5.027 -11.336 -8.051 1.00 1.00 H +ATOM 2165 H2' C B 67 4.796 -9.763 -6.350 1.00 1.00 H +ATOM 2166 HO2' C B 67 2.702 -9.208 -5.506 1.00 1.00 H +ATOM 2167 H1' C B 67 3.213 -11.233 -4.598 1.00 1.00 H +ATOM 2168 H41 C B 67 9.042 -11.528 -2.070 1.00 1.00 H +ATOM 2169 H42 C B 67 9.569 -12.615 -3.335 1.00 1.00 H +ATOM 2170 H5 C B 67 8.177 -13.247 -5.197 1.00 1.00 H +ATOM 2171 H6 C B 67 5.978 -12.977 -6.247 1.00 1.00 H +ATOM 2172 P U B 68 3.849 -9.327 -9.601 1.00 1.00 P +ATOM 2173 OP1 U B 68 2.875 -8.939 -10.644 1.00 1.00 O +ATOM 2174 OP2 U B 68 5.231 -9.697 -9.984 1.00 1.00 O +ATOM 2175 O5' U B 68 3.927 -8.138 -8.516 1.00 1.00 O +ATOM 2176 C5' U B 68 2.734 -7.615 -7.924 1.00 1.00 C +ATOM 2177 C4' U B 68 3.041 -6.767 -6.693 1.00 1.00 C +ATOM 2178 O4' U B 68 3.878 -7.491 -5.798 1.00 1.00 O +ATOM 2179 C3' U B 68 3.768 -5.467 -6.995 1.00 1.00 C +ATOM 2180 O3' U B 68 2.820 -4.421 -7.231 1.00 1.00 O +ATOM 2181 C2' U B 68 4.537 -5.188 -5.714 1.00 1.00 C +ATOM 2182 O2' U B 68 3.802 -4.321 -4.846 1.00 1.00 O +ATOM 2183 C1' U B 68 4.724 -6.571 -5.090 1.00 1.00 C +ATOM 2184 N1 U B 68 6.107 -7.079 -5.184 1.00 1.00 N +ATOM 2185 C2 U B 68 6.960 -6.843 -4.121 1.00 1.00 C +ATOM 2186 O2 U B 68 6.600 -6.232 -3.118 1.00 1.00 O +ATOM 2187 N3 U B 68 8.246 -7.335 -4.254 1.00 1.00 N +ATOM 2188 C4 U B 68 8.746 -8.032 -5.342 1.00 1.00 C +ATOM 2189 O4 U B 68 9.911 -8.423 -5.352 1.00 1.00 O +ATOM 2190 C5 U B 68 7.787 -8.232 -6.404 1.00 1.00 C +ATOM 2191 C6 U B 68 6.520 -7.760 -6.296 1.00 1.00 C +ATOM 2192 H5' U B 68 2.089 -8.446 -7.632 1.00 1.00 H +ATOM 2193 H5'' U B 68 2.213 -7.002 -8.657 1.00 1.00 H +ATOM 2194 H4' U B 68 2.108 -6.540 -6.182 1.00 1.00 H +ATOM 2195 H3' U B 68 4.449 -5.588 -7.841 1.00 1.00 H +ATOM 2196 H2' U B 68 5.508 -4.758 -5.956 1.00 1.00 H +ATOM 2197 HO2' U B 68 4.425 -3.679 -4.493 1.00 1.00 H +ATOM 2198 H1' U B 68 4.421 -6.538 -4.045 1.00 1.00 H +ATOM 2199 H3 U B 68 8.881 -7.169 -3.487 1.00 1.00 H +ATOM 2200 H5 U B 68 8.085 -8.771 -7.303 1.00 1.00 H +ATOM 2201 H6 U B 68 5.818 -7.924 -7.114 1.00 1.00 H +ATOM 2202 P U B 69 3.255 -3.081 -8.014 1.00 1.00 P +ATOM 2203 OP1 U B 69 2.034 -2.434 -8.544 1.00 1.00 O +ATOM 2204 OP2 U B 69 4.366 -3.421 -8.929 1.00 1.00 O +ATOM 2205 O5' U B 69 3.841 -2.151 -6.835 1.00 1.00 O +ATOM 2206 C5' U B 69 3.019 -1.771 -5.728 1.00 1.00 C +ATOM 2207 C4' U B 69 3.859 -1.311 -4.540 1.00 1.00 C +ATOM 2208 O4' U B 69 4.727 -2.363 -4.128 1.00 1.00 O +ATOM 2209 C3' U B 69 4.753 -0.117 -4.825 1.00 1.00 C +ATOM 2210 O3' U B 69 4.037 1.104 -4.573 1.00 1.00 O +ATOM 2211 C2' U B 69 5.888 -0.294 -3.823 1.00 1.00 C +ATOM 2212 O2' U B 69 5.632 0.396 -2.599 1.00 1.00 O +ATOM 2213 C1' U B 69 5.936 -1.801 -3.591 1.00 1.00 C +ATOM 2214 N1 U B 69 7.073 -2.455 -4.268 1.00 1.00 N +ATOM 2215 C2 U B 69 8.215 -2.708 -3.532 1.00 1.00 C +ATOM 2216 O2 U B 69 8.306 -2.412 -2.343 1.00 1.00 O +ATOM 2217 N3 U B 69 9.255 -3.314 -4.214 1.00 1.00 N +ATOM 2218 C4 U B 69 9.251 -3.684 -5.549 1.00 1.00 C +ATOM 2219 O4 U B 69 10.235 -4.219 -6.055 1.00 1.00 O +ATOM 2220 C5 U B 69 8.016 -3.381 -6.239 1.00 1.00 C +ATOM 2221 C6 U B 69 6.985 -2.789 -5.591 1.00 1.00 C +ATOM 2222 H5' U B 69 2.410 -2.624 -5.424 1.00 1.00 H +ATOM 2223 H5'' U B 69 2.362 -0.957 -6.034 1.00 1.00 H +ATOM 2224 H4' U B 69 3.196 -1.071 -3.711 1.00 1.00 H +ATOM 2225 H3' U B 69 5.130 -0.153 -5.850 1.00 1.00 H +ATOM 2226 H2' U B 69 6.829 0.033 -4.269 1.00 1.00 H +ATOM 2227 HO2' U B 69 5.421 -0.265 -1.939 1.00 1.00 H +ATOM 2228 H1' U B 69 5.983 -2.003 -2.522 1.00 1.00 H +ATOM 2229 H3 U B 69 10.097 -3.506 -3.689 1.00 1.00 H +ATOM 2230 H5 U B 69 7.916 -3.631 -7.295 1.00 1.00 H +ATOM 2231 H6 U B 69 6.065 -2.574 -6.135 1.00 1.00 H +ATOM 2232 P G B 70 4.547 2.514 -5.181 1.00 1.00 P +ATOM 2233 OP1 G B 70 3.525 3.545 -4.897 1.00 1.00 O +ATOM 2234 OP2 G B 70 4.999 2.284 -6.572 1.00 1.00 O +ATOM 2235 O5' G B 70 5.838 2.823 -4.273 1.00 1.00 O +ATOM 2236 C5' G B 70 5.708 2.852 -2.852 1.00 1.00 C +ATOM 2237 C4' G B 70 7.043 2.609 -2.158 1.00 1.00 C +ATOM 2238 O4' G B 70 7.669 1.467 -2.745 1.00 1.00 O +ATOM 2239 C3' G B 70 8.048 3.744 -2.278 1.00 1.00 C +ATOM 2240 O3' G B 70 7.923 4.601 -1.138 1.00 1.00 O +ATOM 2241 C2' G B 70 9.397 3.044 -2.224 1.00 1.00 C +ATOM 2242 O2' G B 70 9.966 3.110 -0.913 1.00 1.00 O +ATOM 2243 C1' G B 70 9.087 1.608 -2.634 1.00 1.00 C +ATOM 2244 N9 G B 70 9.735 1.207 -3.899 1.00 1.00 N +ATOM 2245 C8 G B 70 9.229 1.137 -5.173 1.00 1.00 C +ATOM 2246 N7 G B 70 10.077 0.677 -6.051 1.00 1.00 N +ATOM 2247 C5 G B 70 11.227 0.426 -5.308 1.00 1.00 C +ATOM 2248 C6 G B 70 12.487 -0.086 -5.722 1.00 1.00 C +ATOM 2249 O6 G B 70 12.838 -0.432 -6.849 1.00 1.00 O +ATOM 2250 N1 G B 70 13.374 -0.180 -4.657 1.00 1.00 N +ATOM 2251 C2 G B 70 13.085 0.172 -3.356 1.00 1.00 C +ATOM 2252 N2 G B 70 14.066 0.018 -2.469 1.00 1.00 N +ATOM 2253 N3 G B 70 11.902 0.651 -2.965 1.00 1.00 N +ATOM 2254 C4 G B 70 11.026 0.751 -3.991 1.00 1.00 C +ATOM 2255 H5' G B 70 5.000 2.079 -2.544 1.00 1.00 H +ATOM 2256 H5'' G B 70 5.325 3.826 -2.548 1.00 1.00 H +ATOM 2257 H4' G B 70 6.862 2.400 -1.106 1.00 1.00 H +ATOM 2258 H3' G B 70 7.922 4.290 -3.213 1.00 1.00 H +ATOM 2259 H2' G B 70 10.071 3.497 -2.960 1.00 1.00 H +ATOM 2260 HO2' G B 70 10.260 2.227 -0.679 1.00 1.00 H +ATOM 2261 H1' G B 70 9.434 0.935 -1.854 1.00 1.00 H +ATOM 2262 H8 G B 70 8.216 1.443 -5.428 1.00 1.00 H +ATOM 2263 H1 G B 70 14.292 -0.540 -4.873 1.00 1.00 H +ATOM 2264 H21 G B 70 14.962 -0.343 -2.764 1.00 1.00 H +ATOM 2265 H22 G B 70 13.912 0.261 -1.501 1.00 1.00 H +ATOM 2266 P G B 71 8.722 5.995 -1.058 1.00 1.00 P +ATOM 2267 OP1 G B 71 7.968 6.909 -0.174 1.00 1.00 O +ATOM 2268 OP2 G B 71 9.058 6.414 -2.437 1.00 1.00 O +ATOM 2269 O5' G B 71 10.092 5.588 -0.305 1.00 1.00 O +ATOM 2270 C5' G B 71 10.099 5.274 1.095 1.00 1.00 C +ATOM 2271 C4' G B 71 11.516 5.030 1.608 1.00 1.00 C +ATOM 2272 O4' G B 71 12.041 3.828 1.035 1.00 1.00 O +ATOM 2273 C3' G B 71 12.493 6.155 1.274 1.00 1.00 C +ATOM 2274 O3' G B 71 12.625 7.033 2.397 1.00 1.00 O +ATOM 2275 C2' G B 71 13.800 5.425 1.023 1.00 1.00 C +ATOM 2276 O2' G B 71 14.557 5.263 2.228 1.00 1.00 O +ATOM 2277 C1' G B 71 13.330 4.092 0.468 1.00 1.00 C +ATOM 2278 N9 G B 71 13.168 4.093 -0.988 1.00 1.00 N +ATOM 2279 C8 G B 71 12.049 4.411 -1.713 1.00 1.00 C +ATOM 2280 N7 G B 71 12.208 4.316 -3.002 1.00 1.00 N +ATOM 2281 C5 G B 71 13.529 3.903 -3.148 1.00 1.00 C +ATOM 2282 C6 G B 71 14.271 3.633 -4.330 1.00 1.00 C +ATOM 2283 O6 G B 71 13.898 3.708 -5.499 1.00 1.00 O +ATOM 2284 N1 G B 71 15.570 3.243 -4.037 1.00 1.00 N +ATOM 2285 C2 G B 71 16.093 3.126 -2.768 1.00 1.00 C +ATOM 2286 N2 G B 71 17.366 2.736 -2.690 1.00 1.00 N +ATOM 2287 N3 G B 71 15.399 3.380 -1.652 1.00 1.00 N +ATOM 2288 C4 G B 71 14.126 3.764 -1.919 1.00 1.00 C +ATOM 2289 H5' G B 71 9.504 4.379 1.265 1.00 1.00 H +ATOM 2290 H5'' G B 71 9.658 6.105 1.650 1.00 1.00 H +ATOM 2291 H4' G B 71 11.478 4.904 2.687 1.00 1.00 H +ATOM 2292 H3' G B 71 12.171 6.695 0.380 1.00 1.00 H +ATOM 2293 H2' G B 71 14.380 5.949 0.269 1.00 1.00 H +ATOM 2294 HO2' G B 71 14.024 4.741 2.833 1.00 1.00 H +ATOM 2295 H1' G B 71 14.026 3.304 0.753 1.00 1.00 H +ATOM 2296 H8 G B 71 11.108 4.712 -1.253 1.00 1.00 H +ATOM 2297 H1 G B 71 16.160 3.032 -4.828 1.00 1.00 H +ATOM 2298 H21 G B 71 17.885 2.545 -3.527 1.00 1.00 H +ATOM 2299 H22 G B 71 17.807 2.632 -1.786 1.00 1.00 H +ATOM 2300 P U B 72 12.825 8.617 2.181 1.00 1.00 P +ATOM 2301 OP1 U B 72 12.830 9.267 3.510 1.00 1.00 O +ATOM 2302 OP2 U B 72 11.870 9.068 1.144 1.00 1.00 O +ATOM 2303 O5' U B 72 14.312 8.716 1.568 1.00 1.00 O +ATOM 2304 C5' U B 72 15.460 8.627 2.418 1.00 1.00 C +ATOM 2305 C4' U B 72 16.756 8.625 1.612 1.00 1.00 C +ATOM 2306 O4' U B 72 16.787 7.497 0.748 1.00 1.00 O +ATOM 2307 C3' U B 72 16.945 9.838 0.720 1.00 1.00 C +ATOM 2308 O3' U B 72 17.584 10.889 1.456 1.00 1.00 O +ATOM 2309 C2' U B 72 17.870 9.317 -0.373 1.00 1.00 C +ATOM 2310 O2' U B 72 19.247 9.538 -0.044 1.00 1.00 O +ATOM 2311 C1' U B 72 17.540 7.821 -0.431 1.00 1.00 C +ATOM 2312 N1 U B 72 16.707 7.440 -1.588 1.00 1.00 N +ATOM 2313 C2 U B 72 17.342 6.982 -2.727 1.00 1.00 C +ATOM 2314 O2 U B 72 18.566 6.881 -2.797 1.00 1.00 O +ATOM 2315 N3 U B 72 16.520 6.644 -3.787 1.00 1.00 N +ATOM 2316 C4 U B 72 15.139 6.723 -3.807 1.00 1.00 C +ATOM 2317 O4 U B 72 14.506 6.395 -4.809 1.00 1.00 O +ATOM 2318 C5 U B 72 14.559 7.212 -2.576 1.00 1.00 C +ATOM 2319 C6 U B 72 15.343 7.549 -1.524 1.00 1.00 C +ATOM 2320 H5' U B 72 15.403 7.709 3.006 1.00 1.00 H +ATOM 2321 H5'' U B 72 15.468 9.481 3.095 1.00 1.00 H +ATOM 2322 H4' U B 72 17.598 8.550 2.297 1.00 1.00 H +ATOM 2323 H3' U B 72 15.991 10.166 0.299 1.00 1.00 H +ATOM 2324 H2' U B 72 17.621 9.787 -1.324 1.00 1.00 H +ATOM 2325 HO2' U B 72 19.720 9.667 -0.870 1.00 1.00 H +ATOM 2326 H1' U B 72 18.465 7.245 -0.441 1.00 1.00 H +ATOM 2327 H3 U B 72 16.971 6.307 -4.626 1.00 1.00 H +ATOM 2328 H5 U B 72 13.477 7.311 -2.494 1.00 1.00 H +ATOM 2329 H6 U B 72 14.880 7.915 -0.608 1.00 1.00 H +ATOM 2330 P U B 73 17.087 12.416 1.309 1.00 1.00 P +ATOM 2331 OP1 U B 73 17.873 13.255 2.242 1.00 1.00 O +ATOM 2332 OP2 U B 73 15.609 12.430 1.376 1.00 1.00 O +ATOM 2333 O5' U B 73 17.525 12.792 -0.193 1.00 1.00 O +ATOM 2334 C5' U B 73 18.873 13.170 -0.487 1.00 1.00 C +ATOM 2335 C4' U B 73 19.119 13.256 -1.990 1.00 1.00 C +ATOM 2336 O4' U B 73 18.909 11.984 -2.591 1.00 1.00 O +ATOM 2337 C3' U B 73 18.203 14.217 -2.728 1.00 1.00 C +ATOM 2338 O3' U B 73 18.756 15.536 -2.729 1.00 1.00 O +ATOM 2339 C2' U B 73 18.192 13.664 -4.142 1.00 1.00 C +ATOM 2340 O2' U B 73 19.203 14.275 -4.953 1.00 1.00 O +ATOM 2341 C1' U B 73 18.455 12.172 -3.941 1.00 1.00 C +ATOM 2342 N1 U B 73 17.253 11.333 -4.121 1.00 1.00 N +ATOM 2343 C2 U B 73 17.057 10.740 -5.354 1.00 1.00 C +ATOM 2344 O2 U B 73 17.834 10.906 -6.291 1.00 1.00 O +ATOM 2345 N3 U B 73 15.929 9.948 -5.473 1.00 1.00 N +ATOM 2346 C4 U B 73 14.995 9.702 -4.481 1.00 1.00 C +ATOM 2347 O4 U B 73 14.027 8.975 -4.699 1.00 1.00 O +ATOM 2348 C5 U B 73 15.279 10.363 -3.227 1.00 1.00 C +ATOM 2349 C6 U B 73 16.378 11.144 -3.086 1.00 1.00 C +ATOM 2350 H5' U B 73 19.553 12.432 -0.056 1.00 1.00 H +ATOM 2351 H5'' U B 73 19.076 14.142 -0.039 1.00 1.00 H +ATOM 2352 H4' U B 73 20.154 13.546 -2.161 1.00 1.00 H +ATOM 2353 H3' U B 73 17.197 14.205 -2.298 1.00 1.00 H +ATOM 2354 H2' U B 73 17.207 13.807 -4.583 1.00 1.00 H +ATOM 2355 HO2' U B 73 19.842 14.675 -4.358 1.00 1.00 H +ATOM 2356 H1' U B 73 19.232 11.847 -4.629 1.00 1.00 H +ATOM 2357 H3 U B 73 15.773 9.507 -6.369 1.00 1.00 H +ATOM 2358 H5 U B 73 14.601 10.232 -2.385 1.00 1.00 H +ATOM 2359 H6 U B 73 16.567 11.632 -2.130 1.00 1.00 H +ATOM 2360 P C B 74 17.817 16.803 -3.055 1.00 1.00 P +ATOM 2361 OP1 C B 74 18.642 18.028 -2.970 1.00 1.00 O +ATOM 2362 OP2 C B 74 16.583 16.686 -2.247 1.00 1.00 O +ATOM 2363 O5' C B 74 17.429 16.571 -4.603 1.00 1.00 O +ATOM 2364 C5' C B 74 18.394 16.785 -5.637 1.00 1.00 C +ATOM 2365 C4' C B 74 17.933 16.212 -6.976 1.00 1.00 C +ATOM 2366 O4' C B 74 17.549 14.852 -6.821 1.00 1.00 O +ATOM 2367 C3' C B 74 16.725 16.903 -7.579 1.00 1.00 C +ATOM 2368 O3' C B 74 17.138 18.043 -8.337 1.00 1.00 O +ATOM 2369 C2' C B 74 16.166 15.836 -8.512 1.00 1.00 C +ATOM 2370 O2' C B 74 16.678 15.979 -9.843 1.00 1.00 O +ATOM 2371 C1' C B 74 16.621 14.521 -7.866 1.00 1.00 C +ATOM 2372 N1 C B 74 15.517 13.746 -7.261 1.00 1.00 N +ATOM 2373 C2 C B 74 14.977 12.709 -8.005 1.00 1.00 C +ATOM 2374 O2 C B 74 15.406 12.471 -9.132 1.00 1.00 O +ATOM 2375 N3 C B 74 13.968 11.978 -7.454 1.00 1.00 N +ATOM 2376 C4 C B 74 13.509 12.253 -6.225 1.00 1.00 C +ATOM 2377 N4 C B 74 12.521 11.517 -5.716 1.00 1.00 N +ATOM 2378 C5 C B 74 14.064 13.324 -5.456 1.00 1.00 C +ATOM 2379 C6 C B 74 15.062 14.041 -6.009 1.00 1.00 C +ATOM 2380 H5' C B 74 19.337 16.313 -5.353 1.00 1.00 H +ATOM 2381 H5'' C B 74 18.556 17.856 -5.752 1.00 1.00 H +ATOM 2382 H4' C B 74 18.761 16.258 -7.681 1.00 1.00 H +ATOM 2383 H3' C B 74 15.998 17.170 -6.807 1.00 1.00 H +ATOM 2384 H2' C B 74 15.082 15.881 -8.514 1.00 1.00 H +ATOM 2385 HO2' C B 74 17.539 15.558 -9.864 1.00 1.00 H +ATOM 2386 H1' C B 74 17.129 13.907 -8.609 1.00 1.00 H +ATOM 2387 H41 C B 74 12.126 10.757 -6.260 1.00 1.00 H +ATOM 2388 H42 C B 74 12.166 11.714 -4.792 1.00 1.00 H +ATOM 2389 H5 C B 74 13.695 13.550 -4.455 1.00 1.00 H +ATOM 2390 H6 C B 74 15.509 14.864 -5.451 1.00 1.00 H +ATOM 2391 P U B 75 16.427 19.473 -8.118 1.00 1.00 P +ATOM 2392 OP1 U B 75 17.383 20.529 -8.520 1.00 1.00 O +ATOM 2393 OP2 U B 75 15.843 19.492 -6.760 1.00 1.00 O +ATOM 2394 O5' U B 75 15.219 19.460 -9.188 1.00 1.00 O +ATOM 2395 C5' U B 75 15.460 19.083 -10.546 1.00 1.00 C +ATOM 2396 C4' U B 75 14.406 18.105 -11.068 1.00 1.00 C +ATOM 2397 O4' U B 75 14.319 16.958 -10.230 1.00 1.00 O +ATOM 2398 C3' U B 75 12.997 18.665 -11.136 1.00 1.00 C +ATOM 2399 O3' U B 75 12.807 19.325 -12.393 1.00 1.00 O +ATOM 2400 C2' U B 75 12.122 17.420 -11.070 1.00 1.00 C +ATOM 2401 O2' U B 75 11.706 17.000 -12.374 1.00 1.00 O +ATOM 2402 C1' U B 75 13.019 16.374 -10.402 1.00 1.00 C +ATOM 2403 N1 U B 75 12.518 15.902 -9.086 1.00 1.00 N +ATOM 2404 C2 U B 75 11.771 14.740 -9.082 1.00 1.00 C +ATOM 2405 O2 U B 75 11.518 14.121 -10.113 1.00 1.00 O +ATOM 2406 N3 U B 75 11.321 14.311 -7.845 1.00 1.00 N +ATOM 2407 C4 U B 75 11.551 14.936 -6.631 1.00 1.00 C +ATOM 2408 O4 U B 75 11.104 14.464 -5.589 1.00 1.00 O +ATOM 2409 C5 U B 75 12.340 16.144 -6.731 1.00 1.00 C +ATOM 2410 C6 U B 75 12.792 16.583 -7.931 1.00 1.00 C +ATOM 2411 H5' U B 75 16.445 18.620 -10.618 1.00 1.00 H +ATOM 2412 H5'' U B 75 15.445 19.979 -11.167 1.00 1.00 H +ATOM 2413 H4' U B 75 14.703 17.778 -12.065 1.00 1.00 H +ATOM 2414 H3' U B 75 12.799 19.333 -10.296 1.00 1.00 H +ATOM 2415 H2' U B 75 11.259 17.616 -10.432 1.00 1.00 H +ATOM 2416 HO2' U B 75 11.979 16.088 -12.481 1.00 1.00 H +ATOM 2417 H1' U B 75 13.111 15.519 -11.071 1.00 1.00 H +ATOM 2418 H3 U B 75 10.774 13.462 -7.827 1.00 1.00 H +ATOM 2419 H5 U B 75 12.575 16.709 -5.828 1.00 1.00 H +ATOM 2420 H6 U B 75 13.384 17.498 -7.977 1.00 1.00 H +ATOM 2421 P U B 76 11.647 20.424 -12.589 1.00 1.00 P +ATOM 2422 OP1 U B 76 11.895 21.136 -13.863 1.00 1.00 O +ATOM 2423 OP2 U B 76 11.521 21.191 -11.330 1.00 1.00 O +ATOM 2424 O5' U B 76 10.322 19.524 -12.765 1.00 1.00 O +ATOM 2425 C5' U B 76 9.995 18.949 -14.037 1.00 1.00 C +ATOM 2426 C4' U B 76 8.639 18.247 -14.007 1.00 1.00 C +ATOM 2427 O4' U B 76 8.697 17.134 -13.124 1.00 1.00 O +ATOM 2428 C3' U B 76 7.492 19.123 -13.531 1.00 1.00 C +ATOM 2429 O3' U B 76 6.846 19.727 -14.655 1.00 1.00 O +ATOM 2430 C2' U B 76 6.536 18.145 -12.863 1.00 1.00 C +ATOM 2431 O2' U B 76 5.495 17.742 -13.759 1.00 1.00 O +ATOM 2432 C1' U B 76 7.428 16.964 -12.479 1.00 1.00 C +ATOM 2433 N1 U B 76 7.689 16.871 -11.031 1.00 1.00 N +ATOM 2434 C2 U B 76 6.903 16.013 -10.284 1.00 1.00 C +ATOM 2435 O2 U B 76 6.011 15.335 -10.791 1.00 1.00 O +ATOM 2436 N3 U B 76 7.179 15.959 -8.930 1.00 1.00 N +ATOM 2437 C4 U B 76 8.159 16.679 -8.268 1.00 1.00 C +ATOM 2438 O4 U B 76 8.318 16.553 -7.055 1.00 1.00 O +ATOM 2439 C5 U B 76 8.932 17.549 -9.126 1.00 1.00 C +ATOM 2440 C6 U B 76 8.679 17.618 -10.456 1.00 1.00 C +ATOM 2441 H5' U B 76 10.763 18.223 -14.308 1.00 1.00 H +ATOM 2442 H5'' U B 76 9.970 19.737 -14.788 1.00 1.00 H +ATOM 2443 H4' U B 76 8.412 17.878 -15.005 1.00 1.00 H +ATOM 2444 H3' U B 76 7.841 19.874 -12.821 1.00 1.00 H +ATOM 2445 H2' U B 76 6.115 18.598 -11.962 1.00 1.00 H +ATOM 2446 HO2' U B 76 5.381 16.794 -13.656 1.00 1.00 H +ATOM 2447 H1' U B 76 6.970 16.037 -12.826 1.00 1.00 H +ATOM 2448 H3 U B 76 6.614 15.336 -8.372 1.00 1.00 H +ATOM 2449 H5 U B 76 9.727 18.158 -8.698 1.00 1.00 H +ATOM 2450 H6 U B 76 9.277 18.283 -11.079 1.00 1.00 H +ATOM 2451 P C B 77 5.778 20.910 -14.435 1.00 1.00 P +ATOM 2452 OP1 C B 77 5.283 21.340 -15.762 1.00 1.00 O +ATOM 2453 OP2 C B 77 6.368 21.902 -13.509 1.00 1.00 O +ATOM 2454 O5' C B 77 4.579 20.154 -13.669 1.00 1.00 O +ATOM 2455 C5' C B 77 3.987 20.727 -12.500 1.00 1.00 C +ATOM 2456 C4' C B 77 2.941 19.798 -11.887 1.00 1.00 C +ATOM 2457 O4' C B 77 3.583 18.668 -11.300 1.00 1.00 O +ATOM 2458 C3' C B 77 2.104 20.446 -10.795 1.00 1.00 C +ATOM 2459 O3' C B 77 0.894 20.959 -11.360 1.00 1.00 O +ATOM 2460 C2' C B 77 1.783 19.304 -9.843 1.00 1.00 C +ATOM 2461 O2' C B 77 0.490 18.750 -10.115 1.00 1.00 O +ATOM 2462 C1' C B 77 2.890 18.283 -10.104 1.00 1.00 C +ATOM 2463 N1 C B 77 3.892 18.204 -9.027 1.00 1.00 N +ATOM 2464 C2 C B 77 3.609 17.392 -7.940 1.00 1.00 C +ATOM 2465 O2 C B 77 2.549 16.773 -7.894 1.00 1.00 O +ATOM 2466 N3 C B 77 4.530 17.305 -6.941 1.00 1.00 N +ATOM 2467 C4 C B 77 5.682 17.987 -7.007 1.00 1.00 C +ATOM 2468 N4 C B 77 6.563 17.877 -6.012 1.00 1.00 N +ATOM 2469 C5 C B 77 5.977 18.828 -8.126 1.00 1.00 C +ATOM 2470 C6 C B 77 5.060 18.906 -9.108 1.00 1.00 C +ATOM 2471 H5' C B 77 3.511 21.671 -12.768 1.00 1.00 H +ATOM 2472 H5'' C B 77 4.767 20.918 -11.764 1.00 1.00 H +ATOM 2473 H4' C B 77 2.280 19.444 -12.676 1.00 1.00 H +ATOM 2474 H3' C B 77 2.669 21.230 -10.287 1.00 1.00 H +ATOM 2475 H2' C B 77 1.840 19.657 -8.810 1.00 1.00 H +ATOM 2476 HO2' C B 77 -0.070 18.950 -9.361 1.00 1.00 H +ATOM 2477 H1' C B 77 2.445 17.300 -10.248 1.00 1.00 H +ATOM 2478 H41 C B 77 6.361 17.288 -5.225 1.00 1.00 H +ATOM 2479 H42 C B 77 7.434 18.386 -6.052 1.00 1.00 H +ATOM 2480 H5 C B 77 6.913 19.385 -8.181 1.00 1.00 H +ATOM 2481 H6 C B 77 5.251 19.538 -9.977 1.00 1.00 H +ATOM 2482 P C B 78 0.016 22.043 -10.558 1.00 1.00 P +ATOM 2483 OP1 C B 78 -1.255 22.243 -11.291 1.00 1.00 O +ATOM 2484 OP2 C B 78 0.880 23.204 -10.248 1.00 1.00 O +ATOM 2485 O5' C B 78 -0.314 21.276 -9.183 1.00 1.00 O +ATOM 2486 C5' C B 78 -0.145 21.937 -7.926 1.00 1.00 C +ATOM 2487 C4' C B 78 -0.808 21.165 -6.791 1.00 1.00 C +ATOM 2488 O4' C B 78 -0.038 20.004 -6.484 1.00 1.00 O +ATOM 2489 C3' C B 78 -0.944 21.959 -5.504 1.00 1.00 C +ATOM 2490 O3' C B 78 -2.230 22.584 -5.466 1.00 1.00 O +ATOM 2491 C2' C B 78 -0.840 20.909 -4.407 1.00 1.00 C +ATOM 2492 O2' C B 78 -2.135 20.476 -3.973 1.00 1.00 O +ATOM 2493 C1' C B 78 -0.065 19.769 -5.070 1.00 1.00 C +ATOM 2494 N1 C B 78 1.332 19.656 -4.611 1.00 1.00 N +ATOM 2495 C2 C B 78 1.549 19.106 -3.359 1.00 1.00 C +ATOM 2496 O2 C B 78 0.595 18.740 -2.674 1.00 1.00 O +ATOM 2497 N3 C B 78 2.832 18.989 -2.918 1.00 1.00 N +ATOM 2498 C4 C B 78 3.859 19.395 -3.677 1.00 1.00 C +ATOM 2499 N4 C B 78 5.103 19.267 -3.215 1.00 1.00 N +ATOM 2500 C5 C B 78 3.639 19.963 -4.971 1.00 1.00 C +ATOM 2501 C6 C B 78 2.366 20.075 -5.396 1.00 1.00 C +ATOM 2502 H5' C B 78 -0.588 22.931 -7.984 1.00 1.00 H +ATOM 2503 H5'' C B 78 0.921 22.035 -7.716 1.00 1.00 H +ATOM 2504 H4' C B 78 -1.797 20.846 -7.116 1.00 1.00 H +ATOM 2505 H3' C B 78 -0.143 22.694 -5.415 1.00 1.00 H +ATOM 2506 H2' C B 78 -0.265 21.309 -3.567 1.00 1.00 H +ATOM 2507 HO2' C B 78 -2.508 19.941 -4.677 1.00 1.00 H +ATOM 2508 H1' C B 78 -0.578 18.831 -4.875 1.00 1.00 H +ATOM 2509 H41 C B 78 5.265 18.865 -2.301 1.00 1.00 H +ATOM 2510 H42 C B 78 5.884 19.570 -3.781 1.00 1.00 H +ATOM 2511 H5 C B 78 4.473 20.295 -5.590 1.00 1.00 H +ATOM 2512 H6 C B 78 2.161 20.503 -6.378 1.00 1.00 H +ATOM 2513 P U B 79 -2.471 23.900 -4.574 1.00 1.00 P +ATOM 2514 OP1 U B 79 -3.613 24.649 -5.148 1.00 1.00 O +ATOM 2515 OP2 U B 79 -1.168 24.575 -4.382 1.00 1.00 O +ATOM 2516 O5' U B 79 -2.932 23.277 -3.164 1.00 1.00 O +ATOM 2517 C5' U B 79 -2.319 23.705 -1.946 1.00 1.00 C +ATOM 2518 C4' U B 79 -2.513 22.681 -0.831 1.00 1.00 C +ATOM 2519 O4' U B 79 -1.484 21.686 -0.894 1.00 1.00 O +ATOM 2520 C3' U B 79 -2.471 23.287 0.564 1.00 1.00 C +ATOM 2521 O3' U B 79 -3.804 23.552 1.011 1.00 1.00 O +ATOM 2522 C2' U B 79 -1.849 22.201 1.425 1.00 1.00 C +ATOM 2523 O2' U B 79 -2.852 21.405 2.065 1.00 1.00 O +ATOM 2524 C1' U B 79 -1.038 21.374 0.434 1.00 1.00 C +ATOM 2525 N1 U B 79 0.414 21.626 0.498 1.00 1.00 N +ATOM 2526 C2 U B 79 1.046 21.347 1.693 1.00 1.00 C +ATOM 2527 O2 U B 79 0.435 20.927 2.673 1.00 1.00 O +ATOM 2528 N3 U B 79 2.410 21.570 1.725 1.00 1.00 N +ATOM 2529 C4 U B 79 3.186 22.042 0.679 1.00 1.00 C +ATOM 2530 O4 U B 79 4.396 22.202 0.819 1.00 1.00 O +ATOM 2531 C5 U B 79 2.441 22.307 -0.532 1.00 1.00 C +ATOM 2532 C6 U B 79 1.105 22.096 -0.586 1.00 1.00 C +ATOM 2533 H5' U B 79 -2.761 24.653 -1.640 1.00 1.00 H +ATOM 2534 H5'' U B 79 -1.252 23.848 -2.117 1.00 1.00 H +ATOM 2535 H4' U B 79 -3.474 22.189 -0.971 1.00 1.00 H +ATOM 2536 H3' U B 79 -1.860 24.192 0.577 1.00 1.00 H +ATOM 2537 H2' U B 79 -1.182 22.649 2.165 1.00 1.00 H +ATOM 2538 HO2' U B 79 -2.652 20.486 1.875 1.00 1.00 H +ATOM 2539 H1' U B 79 -1.217 20.316 0.628 1.00 1.00 H +ATOM 2540 H3 U B 79 2.886 21.370 2.593 1.00 1.00 H +ATOM 2541 H5 U B 79 2.964 22.681 -1.413 1.00 1.00 H +ATOM 2542 H6 U B 79 0.568 22.305 -1.513 1.00 1.00 H +ATOM 2543 P A B 80 -4.092 24.687 2.116 1.00 1.00 P +ATOM 2544 OP1 A B 80 -5.556 24.892 2.197 1.00 1.00 O +ATOM 2545 OP2 A B 80 -3.200 25.836 1.845 1.00 1.00 O +ATOM 2546 O5' A B 80 -3.607 23.985 3.482 1.00 1.00 O +ATOM 2547 C5' A B 80 -3.358 24.771 4.651 1.00 1.00 C +ATOM 2548 C4' A B 80 -2.702 23.943 5.753 1.00 1.00 C +ATOM 2549 O4' A B 80 -1.599 23.216 5.211 1.00 1.00 O +ATOM 2550 C3' A B 80 -2.181 24.776 6.919 1.00 1.00 C +ATOM 2551 O3' A B 80 -2.421 24.080 8.149 1.00 1.00 O +ATOM 2552 C2' A B 80 -0.686 24.882 6.665 1.00 1.00 C +ATOM 2553 O2' A B 80 0.055 24.861 7.889 1.00 1.00 O +ATOM 2554 C1' A B 80 -0.375 23.659 5.810 1.00 1.00 C +ATOM 2555 N9 A B 80 0.579 23.918 4.716 1.00 1.00 N +ATOM 2556 C8 A B 80 0.335 24.428 3.466 1.00 1.00 C +ATOM 2557 N7 A B 80 1.402 24.534 2.723 1.00 1.00 N +ATOM 2558 C5 A B 80 2.426 24.060 3.538 1.00 1.00 C +ATOM 2559 C6 A B 80 3.807 23.911 3.337 1.00 1.00 C +ATOM 2560 N6 A B 80 4.418 24.237 2.196 1.00 1.00 N +ATOM 2561 N1 A B 80 4.529 23.411 4.354 1.00 1.00 N +ATOM 2562 C2 A B 80 3.914 23.086 5.486 1.00 1.00 C +ATOM 2563 N3 A B 80 2.629 23.178 5.796 1.00 1.00 N +ATOM 2564 C4 A B 80 1.932 23.683 4.755 1.00 1.00 C +ATOM 2565 H5' A B 80 -4.303 25.169 5.019 1.00 1.00 H +ATOM 2566 H5'' A B 80 -2.699 25.599 4.388 1.00 1.00 H +ATOM 2567 H4' A B 80 -3.429 23.228 6.133 1.00 1.00 H +ATOM 2568 H3' A B 80 -2.646 25.765 6.928 1.00 1.00 H +ATOM 2569 H2' A B 80 -0.469 25.793 6.099 1.00 1.00 H +ATOM 2570 HO2' A B 80 0.598 24.069 7.881 1.00 1.00 H +ATOM 2571 H1' A B 80 0.020 22.867 6.446 1.00 1.00 H +ATOM 2572 H8 A B 80 -0.658 24.719 3.125 1.00 1.00 H +ATOM 2573 H61 A B 80 5.416 24.110 2.102 1.00 1.00 H +ATOM 2574 H62 A B 80 3.883 24.613 1.426 1.00 1.00 H +ATOM 2575 H2 A B 80 4.558 22.686 6.270 1.00 1.00 H +ATOM 2576 P A B 81 -2.661 24.895 9.518 1.00 1.00 P +ATOM 2577 OP1 A B 81 -4.098 25.236 9.605 1.00 1.00 O +ATOM 2578 OP2 A B 81 -1.643 25.965 9.604 1.00 1.00 O +ATOM 2579 O5' A B 81 -2.336 23.796 10.651 1.00 1.00 O +ATOM 2580 C5' A B 81 -3.375 23.309 11.507 1.00 1.00 C +ATOM 2581 C4' A B 81 -2.999 21.972 12.141 1.00 1.00 C +ATOM 2582 O4' A B 81 -2.860 20.987 11.114 1.00 1.00 O +ATOM 2583 C3' A B 81 -1.693 22.006 12.928 1.00 1.00 C +ATOM 2584 O3' A B 81 -1.977 22.120 14.328 1.00 1.00 O +ATOM 2585 C2' A B 81 -1.061 20.654 12.646 1.00 1.00 C +ATOM 2586 O2' A B 81 -1.415 19.692 13.646 1.00 1.00 O +ATOM 2587 C1' A B 81 -1.629 20.278 11.285 1.00 1.00 C +ATOM 2588 N9 A B 81 -0.750 20.629 10.156 1.00 1.00 N +ATOM 2589 C8 A B 81 -0.931 21.583 9.188 1.00 1.00 C +ATOM 2590 N7 A B 81 0.042 21.643 8.320 1.00 1.00 N +ATOM 2591 C5 A B 81 0.929 20.658 8.744 1.00 1.00 C +ATOM 2592 C6 A B 81 2.165 20.217 8.246 1.00 1.00 C +ATOM 2593 N6 A B 81 2.744 20.738 7.163 1.00 1.00 N +ATOM 2594 N1 A B 81 2.777 19.221 8.908 1.00 1.00 N +ATOM 2595 C2 A B 81 2.195 18.707 9.986 1.00 1.00 C +ATOM 2596 N3 A B 81 1.043 19.034 10.550 1.00 1.00 N +ATOM 2597 C4 A B 81 0.453 20.036 9.862 1.00 1.00 C +ATOM 2598 H5' A B 81 -4.286 23.182 10.924 1.00 1.00 H +ATOM 2599 H5'' A B 81 -3.557 24.038 12.296 1.00 1.00 H +ATOM 2600 H4' A B 81 -3.803 21.662 12.806 1.00 1.00 H +ATOM 2601 H3' A B 81 -1.049 22.818 12.584 1.00 1.00 H +ATOM 2602 H2' A B 81 0.021 20.758 12.577 1.00 1.00 H +ATOM 2603 HO2' A B 81 -2.340 19.474 13.519 1.00 1.00 H +ATOM 2604 H1' A B 81 -1.825 19.206 11.259 1.00 1.00 H +ATOM 2605 H8 A B 81 -1.807 22.230 9.145 1.00 1.00 H +ATOM 2606 H61 A B 81 3.636 20.384 6.846 1.00 1.00 H +ATOM 2607 H62 A B 81 2.291 21.486 6.660 1.00 1.00 H +ATOM 2608 H2 A B 81 2.745 17.902 10.475 1.00 1.00 H +ATOM 2609 P G B 82 -0.957 22.879 15.321 1.00 1.00 P +ATOM 2610 OP1 G B 82 -1.541 22.862 16.680 1.00 1.00 O +ATOM 2611 OP2 G B 82 -0.578 24.168 14.698 1.00 1.00 O +ATOM 2612 O5' G B 82 0.339 21.919 15.320 1.00 1.00 O +ATOM 2613 C5' G B 82 0.272 20.602 15.873 1.00 1.00 C +ATOM 2614 C4' G B 82 1.537 19.802 15.573 1.00 1.00 C +ATOM 2615 O4' G B 82 1.671 19.656 14.158 1.00 1.00 O +ATOM 2616 C3' G B 82 2.823 20.445 16.087 1.00 1.00 C +ATOM 2617 O3' G B 82 3.225 19.806 17.302 1.00 1.00 O +ATOM 2618 C2' G B 82 3.845 20.141 15.004 1.00 1.00 C +ATOM 2619 O2' G B 82 4.549 18.925 15.274 1.00 1.00 O +ATOM 2620 C1' G B 82 2.993 20.024 13.750 1.00 1.00 C +ATOM 2621 N9 G B 82 2.891 21.277 12.979 1.00 1.00 N +ATOM 2622 C8 G B 82 1.988 22.300 13.114 1.00 1.00 C +ATOM 2623 N7 G B 82 2.164 23.276 12.269 1.00 1.00 N +ATOM 2624 C5 G B 82 3.263 22.874 11.516 1.00 1.00 C +ATOM 2625 C6 G B 82 3.921 23.533 10.440 1.00 1.00 C +ATOM 2626 O6 G B 82 3.655 24.621 9.933 1.00 1.00 O +ATOM 2627 N1 G B 82 4.987 22.783 9.961 1.00 1.00 N +ATOM 2628 C2 G B 82 5.375 21.555 10.452 1.00 1.00 C +ATOM 2629 N2 G B 82 6.425 20.987 9.859 1.00 1.00 N +ATOM 2630 N3 G B 82 4.759 20.934 11.464 1.00 1.00 N +ATOM 2631 C4 G B 82 3.716 21.651 11.944 1.00 1.00 C +ATOM 2632 H5' G B 82 -0.586 20.079 15.448 1.00 1.00 H +ATOM 2633 H5'' G B 82 0.144 20.675 16.953 1.00 1.00 H +ATOM 2634 H4' G B 82 1.439 18.812 16.012 1.00 1.00 H +ATOM 2635 H3' G B 82 2.700 21.521 16.221 1.00 1.00 H +ATOM 2636 H2' G B 82 4.540 20.974 14.903 1.00 1.00 H +ATOM 2637 HO2' G B 82 3.913 18.208 15.226 1.00 1.00 H +ATOM 2638 H1' G B 82 3.401 19.244 13.107 1.00 1.00 H +ATOM 2639 H8 G B 82 1.193 22.296 13.860 1.00 1.00 H +ATOM 2640 H1 G B 82 5.504 23.187 9.193 1.00 1.00 H +ATOM 2641 H21 G B 82 6.890 21.457 9.095 1.00 1.00 H +ATOM 2642 H22 G B 82 6.757 20.087 10.174 1.00 1.00 H +ATOM 2643 P U B 83 4.119 20.596 18.383 1.00 1.00 P +ATOM 2644 OP1 U B 83 4.866 19.598 19.181 1.00 1.00 O +ATOM 2645 OP2 U B 83 3.261 21.591 19.061 1.00 1.00 O +ATOM 2646 O5' U B 83 5.174 21.387 17.459 1.00 1.00 O +ATOM 2647 C5' U B 83 6.402 20.774 17.057 1.00 1.00 C +ATOM 2648 C4' U B 83 7.349 21.793 16.432 1.00 1.00 C +ATOM 2649 O4' U B 83 6.865 22.204 15.159 1.00 1.00 O +ATOM 2650 C3' U B 83 7.511 23.060 17.252 1.00 1.00 C +ATOM 2651 O3' U B 83 8.577 22.900 18.195 1.00 1.00 O +ATOM 2652 C2' U B 83 7.871 24.111 16.211 1.00 1.00 C +ATOM 2653 O2' U B 83 9.287 24.292 16.110 1.00 1.00 O +ATOM 2654 C1' U B 83 7.285 23.553 14.912 1.00 1.00 C +ATOM 2655 N1 U B 83 6.106 24.297 14.422 1.00 1.00 N +ATOM 2656 C2 U B 83 6.322 25.344 13.546 1.00 1.00 C +ATOM 2657 O2 U B 83 7.451 25.671 13.183 1.00 1.00 O +ATOM 2658 N3 U B 83 5.192 26.005 13.101 1.00 1.00 N +ATOM 2659 C4 U B 83 3.884 25.715 13.451 1.00 1.00 C +ATOM 2660 O4 U B 83 2.952 26.371 12.991 1.00 1.00 O +ATOM 2661 C5 U B 83 3.754 24.607 14.370 1.00 1.00 C +ATOM 2662 C6 U B 83 4.846 23.944 14.820 1.00 1.00 C +ATOM 2663 H5' U B 83 6.188 19.990 16.328 1.00 1.00 H +ATOM 2664 H5'' U B 83 6.882 20.330 17.928 1.00 1.00 H +ATOM 2665 H4' U B 83 8.326 21.330 16.296 1.00 1.00 H +ATOM 2666 H3' U B 83 6.574 23.318 17.751 1.00 1.00 H +ATOM 2667 H2' U B 83 7.382 25.053 16.457 1.00 1.00 H +ATOM 2668 HO2' U B 83 9.436 25.126 15.657 1.00 1.00 H +ATOM 2669 H1' U B 83 8.057 23.554 14.145 1.00 1.00 H +ATOM 2670 H3 U B 83 5.335 26.772 12.459 1.00 1.00 H +ATOM 2671 H5 U B 83 2.763 24.302 14.706 1.00 1.00 H +ATOM 2672 H6 U B 83 4.718 23.111 15.513 1.00 1.00 H +ATOM 2673 P C B 84 8.579 23.730 19.578 1.00 1.00 P +ATOM 2674 OP1 C B 84 9.701 23.245 20.410 1.00 1.00 O +ATOM 2675 OP2 C B 84 7.202 23.724 20.121 1.00 1.00 O +ATOM 2676 O5' C B 84 8.923 25.226 19.098 1.00 1.00 O +ATOM 2677 C5' C B 84 10.266 25.596 18.771 1.00 1.00 C +ATOM 2678 C4' C B 84 10.316 26.945 18.062 1.00 1.00 C +ATOM 2679 O4' C B 84 9.417 26.946 16.962 1.00 1.00 O +ATOM 2680 C3' C B 84 9.917 28.129 18.924 1.00 1.00 C +ATOM 2681 O3' C B 84 11.063 28.646 19.611 1.00 1.00 O +ATOM 2682 C2' C B 84 9.411 29.145 17.910 1.00 1.00 C +ATOM 2683 O2' C B 84 10.434 30.079 17.542 1.00 1.00 O +ATOM 2684 C1' C B 84 8.974 28.289 16.721 1.00 1.00 C +ATOM 2685 N1 C B 84 7.511 28.247 16.538 1.00 1.00 N +ATOM 2686 C2 C B 84 6.948 29.103 15.605 1.00 1.00 C +ATOM 2687 O2 C B 84 7.662 29.872 14.965 1.00 1.00 O +ATOM 2688 N3 C B 84 5.599 29.066 15.425 1.00 1.00 N +ATOM 2689 C4 C B 84 4.834 28.223 16.132 1.00 1.00 C +ATOM 2690 N4 C B 84 3.517 28.209 15.931 1.00 1.00 N +ATOM 2691 C5 C B 84 5.411 27.338 17.096 1.00 1.00 C +ATOM 2692 C6 C B 84 6.747 27.383 17.267 1.00 1.00 C +ATOM 2693 H5' C B 84 10.699 24.834 18.119 1.00 1.00 H +ATOM 2694 H5'' C B 84 10.853 25.656 19.686 1.00 1.00 H +ATOM 2695 H4' C B 84 11.323 27.104 17.681 1.00 1.00 H +ATOM 2696 H3' C B 84 9.123 27.851 19.624 1.00 1.00 H +ATOM 2697 H2' C B 84 8.544 29.662 18.318 1.00 1.00 H +ATOM 2698 HO2' C B 84 11.235 29.576 17.379 1.00 1.00 H +ATOM 2699 H1' C B 84 9.445 28.661 15.811 1.00 1.00 H +ATOM 2700 H41 C B 84 3.107 28.827 15.256 1.00 1.00 H +ATOM 2701 H42 C B 84 2.932 27.578 16.458 1.00 1.00 H +ATOM 2702 H5 C B 84 4.792 26.650 17.673 1.00 1.00 H +ATOM 2703 H6 C B 84 7.221 26.724 17.993 1.00 1.00 H +ATOM 2704 P C B 85 10.884 29.623 20.880 1.00 1.00 P +ATOM 2705 OP1 C B 85 12.193 29.746 21.561 1.00 1.00 O +ATOM 2706 OP2 C B 85 9.697 29.175 21.642 1.00 1.00 O +ATOM 2707 O5' C B 85 10.538 31.039 20.197 1.00 1.00 O +ATOM 2708 C5' C B 85 11.575 31.828 19.604 1.00 1.00 C +ATOM 2709 C4' C B 85 11.008 32.983 18.779 1.00 1.00 C +ATOM 2710 O4' C B 85 10.029 32.495 17.866 1.00 1.00 O +ATOM 2711 C3' C B 85 10.310 34.061 19.592 1.00 1.00 C +ATOM 2712 O3' C B 85 11.248 35.058 20.011 1.00 1.00 O +ATOM 2713 C2' C B 85 9.337 34.670 18.596 1.00 1.00 C +ATOM 2714 O2' C B 85 9.904 35.809 17.943 1.00 1.00 O +ATOM 2715 C1' C B 85 9.080 33.540 17.602 1.00 1.00 C +ATOM 2716 N1 C B 85 7.725 32.960 17.705 1.00 1.00 N +ATOM 2717 C2 C B 85 6.750 33.448 16.847 1.00 1.00 C +ATOM 2718 O2 C B 85 7.026 34.336 16.044 1.00 1.00 O +ATOM 2719 N3 C B 85 5.498 32.919 16.926 1.00 1.00 N +ATOM 2720 C4 C B 85 5.213 31.952 17.809 1.00 1.00 C +ATOM 2721 N4 C B 85 3.977 31.455 17.862 1.00 1.00 N +ATOM 2722 C5 C B 85 6.217 31.446 18.695 1.00 1.00 C +ATOM 2723 C6 C B 85 7.453 31.975 18.609 1.00 1.00 C +ATOM 2724 H5' C B 85 12.181 31.192 18.956 1.00 1.00 H +ATOM 2725 H5'' C B 85 12.205 32.235 20.392 1.00 1.00 H +ATOM 2726 H4' C B 85 11.817 33.436 18.208 1.00 1.00 H +ATOM 2727 H3' C B 85 9.780 33.626 20.443 1.00 1.00 H +ATOM 2728 H2' C B 85 8.411 34.937 19.101 1.00 1.00 H +ATOM 2729 HO2' C B 85 10.531 35.481 17.298 1.00 1.00 H +ATOM 2730 H1' C B 85 9.235 33.912 16.592 1.00 1.00 H +ATOM 2731 H41 C B 85 3.265 31.812 17.241 1.00 1.00 H +ATOM 2732 H42 C B 85 3.753 30.728 18.524 1.00 1.00 H +ATOM 2733 H5 C B 85 5.989 30.658 19.414 1.00 1.00 H +ATOM 2734 H6 C B 85 8.242 31.613 19.268 1.00 1.00 H +ATOM 2735 P U B 86 10.853 36.116 21.162 1.00 1.00 P +ATOM 2736 OP1 U B 86 11.904 37.156 21.220 1.00 1.00 O +ATOM 2737 OP2 U B 86 10.495 35.361 22.383 1.00 1.00 O +ATOM 2738 O5' U B 86 9.511 36.792 20.579 1.00 1.00 O +ATOM 2739 C5' U B 86 9.582 37.753 19.521 1.00 1.00 C +ATOM 2740 C4' U B 86 8.206 38.299 19.148 1.00 1.00 C +ATOM 2741 O4' U B 86 7.354 37.243 18.724 1.00 1.00 O +ATOM 2742 C3' U B 86 7.478 38.997 20.290 1.00 1.00 C +ATOM 2743 O3' U B 86 7.728 40.407 20.275 1.00 1.00 O +ATOM 2744 C2' U B 86 6.000 38.690 20.029 1.00 1.00 C +ATOM 2745 O2' U B 86 5.272 39.876 19.692 1.00 1.00 O +ATOM 2746 C1' U B 86 6.012 37.701 18.869 1.00 1.00 C +ATOM 2747 N1 U B 86 5.136 36.529 19.087 1.00 1.00 N +ATOM 2748 C2 U B 86 3.860 36.577 18.560 1.00 1.00 C +ATOM 2749 O2 U B 86 3.452 37.549 17.927 1.00 1.00 O +ATOM 2750 N3 U B 86 3.066 35.469 18.786 1.00 1.00 N +ATOM 2751 C4 U B 86 3.432 34.331 19.486 1.00 1.00 C +ATOM 2752 O4 U B 86 2.641 33.400 19.625 1.00 1.00 O +ATOM 2753 C5 U B 86 4.782 34.366 20.002 1.00 1.00 C +ATOM 2754 C6 U B 86 5.579 35.442 19.793 1.00 1.00 C +ATOM 2755 H5' U B 86 10.029 37.285 18.643 1.00 1.00 H +ATOM 2756 H5'' U B 86 10.214 38.582 19.840 1.00 1.00 H +ATOM 2757 H4' U B 86 8.319 39.000 18.323 1.00 1.00 H +ATOM 2758 H3' U B 86 7.784 38.562 21.245 1.00 1.00 H +ATOM 2759 HO3' U B 86 8.526 40.560 20.789 1.00 1.00 H +ATOM 2760 H2' U B 86 5.560 38.208 20.906 1.00 1.00 H +ATOM 2761 HO2' U B 86 4.957 39.771 18.792 1.00 1.00 H +ATOM 2762 H1' U B 86 5.711 38.212 17.955 1.00 1.00 H +ATOM 2763 H3 U B 86 2.131 35.491 18.406 1.00 1.00 H +ATOM 2764 H5 U B 86 5.162 33.518 20.570 1.00 1.00 H +ATOM 2765 H6 U B 86 6.592 35.443 20.194 1.00 1.00 H +TER 2766 U B 86 +ENDMDL +MODEL 2 +ATOM 1 O5' G A 1 4.544 -38.309 7.499 1.00 1.00 O +ATOM 2 C5' G A 1 5.384 -39.099 6.655 1.00 1.00 C +ATOM 3 C4' G A 1 4.570 -40.129 5.871 1.00 1.00 C +ATOM 4 O4' G A 1 4.030 -41.103 6.771 1.00 1.00 O +ATOM 5 C3' G A 1 3.402 -39.531 5.093 1.00 1.00 C +ATOM 6 O3' G A 1 3.776 -39.354 3.723 1.00 1.00 O +ATOM 7 C2' G A 1 2.320 -40.592 5.192 1.00 1.00 C +ATOM 8 O2' G A 1 2.391 -41.513 4.097 1.00 1.00 O +ATOM 9 C1' G A 1 2.631 -41.276 6.514 1.00 1.00 C +ATOM 10 N9 G A 1 1.896 -40.716 7.662 1.00 1.00 N +ATOM 11 C8 G A 1 2.392 -40.069 8.764 1.00 1.00 C +ATOM 12 N7 G A 1 1.477 -39.697 9.614 1.00 1.00 N +ATOM 13 C5 G A 1 0.286 -40.129 9.037 1.00 1.00 C +ATOM 14 C6 G A 1 -1.051 -40.007 9.505 1.00 1.00 C +ATOM 15 O6 G A 1 -1.451 -39.482 10.543 1.00 1.00 O +ATOM 16 N1 G A 1 -1.955 -40.578 8.620 1.00 1.00 N +ATOM 17 C2 G A 1 -1.618 -41.192 7.432 1.00 1.00 C +ATOM 18 N2 G A 1 -2.628 -41.684 6.713 1.00 1.00 N +ATOM 19 N3 G A 1 -0.362 -41.308 6.989 1.00 1.00 N +ATOM 20 C4 G A 1 0.534 -40.755 7.841 1.00 1.00 C +ATOM 21 H5' G A 1 6.125 -39.610 7.272 1.00 1.00 H +ATOM 22 H5'' G A 1 5.898 -38.448 5.952 1.00 1.00 H +ATOM 23 H4' G A 1 5.231 -40.637 5.172 1.00 1.00 H +ATOM 24 H3' G A 1 3.073 -38.593 5.542 1.00 1.00 H +ATOM 25 H2' G A 1 1.336 -40.121 5.239 1.00 1.00 H +ATOM 26 HO2' G A 1 2.273 -42.395 4.458 1.00 1.00 H +ATOM 27 H1' G A 1 2.408 -42.338 6.431 1.00 1.00 H +ATOM 28 H8 G A 1 3.455 -39.881 8.915 1.00 1.00 H +ATOM 29 H1 G A 1 -2.928 -40.530 8.885 1.00 1.00 H +ATOM 30 H21 G A 1 -3.576 -41.595 7.049 1.00 1.00 H +ATOM 31 H22 G A 1 -2.445 -42.144 5.833 1.00 1.00 H +ATOM 32 HO5' G A 1 3.637 -38.569 7.323 1.00 1.00 H +ATOM 33 P G A 2 3.188 -38.126 2.863 1.00 1.00 P +ATOM 34 OP1 G A 2 3.745 -38.211 1.495 1.00 1.00 O +ATOM 35 OP2 G A 2 3.356 -36.886 3.652 1.00 1.00 O +ATOM 36 O5' G A 2 1.615 -38.463 2.788 1.00 1.00 O +ATOM 37 C5' G A 2 1.148 -39.660 2.161 1.00 1.00 C +ATOM 38 C4' G A 2 -0.355 -39.838 2.361 1.00 1.00 C +ATOM 39 O4' G A 2 -0.646 -40.016 3.744 1.00 1.00 O +ATOM 40 C3' G A 2 -1.186 -38.656 1.890 1.00 1.00 C +ATOM 41 O3' G A 2 -1.545 -38.843 0.514 1.00 1.00 O +ATOM 42 C2' G A 2 -2.421 -38.718 2.778 1.00 1.00 C +ATOM 43 O2' G A 2 -3.483 -39.446 2.151 1.00 1.00 O +ATOM 44 C1' G A 2 -1.922 -39.425 4.040 1.00 1.00 C +ATOM 45 N9 G A 2 -1.733 -38.523 5.189 1.00 1.00 N +ATOM 46 C8 G A 2 -0.579 -37.932 5.635 1.00 1.00 C +ATOM 47 N7 G A 2 -0.740 -37.190 6.695 1.00 1.00 N +ATOM 48 C5 G A 2 -2.100 -37.296 6.974 1.00 1.00 C +ATOM 49 C6 G A 2 -2.867 -36.706 8.018 1.00 1.00 C +ATOM 50 O6 G A 2 -2.485 -35.959 8.917 1.00 1.00 O +ATOM 51 N1 G A 2 -4.204 -37.070 7.937 1.00 1.00 N +ATOM 52 C2 G A 2 -4.741 -37.900 6.975 1.00 1.00 C +ATOM 53 N2 G A 2 -6.049 -38.135 7.060 1.00 1.00 N +ATOM 54 N3 G A 2 -4.022 -38.456 5.994 1.00 1.00 N +ATOM 55 C4 G A 2 -2.715 -38.111 6.057 1.00 1.00 C +ATOM 56 H5' G A 2 1.668 -40.516 2.592 1.00 1.00 H +ATOM 57 H5'' G A 2 1.364 -39.612 1.093 1.00 1.00 H +ATOM 58 H4' G A 2 -0.676 -40.729 1.826 1.00 1.00 H +ATOM 59 H3' G A 2 -0.647 -37.718 2.038 1.00 1.00 H +ATOM 60 H2' G A 2 -2.743 -37.709 3.032 1.00 1.00 H +ATOM 61 HO2' G A 2 -3.228 -40.371 2.138 1.00 1.00 H +ATOM 62 H1' G A 2 -2.626 -40.208 4.315 1.00 1.00 H +ATOM 63 H8 G A 2 0.386 -38.068 5.147 1.00 1.00 H +ATOM 64 H1 G A 2 -4.812 -36.689 8.647 1.00 1.00 H +ATOM 65 H21 G A 2 -6.591 -37.712 7.804 1.00 1.00 H +ATOM 66 H22 G A 2 -6.500 -38.734 6.385 1.00 1.00 H +ATOM 67 P G A 3 -1.839 -37.584 -0.450 1.00 1.00 P +ATOM 68 OP1 G A 3 -2.001 -38.092 -1.832 1.00 1.00 O +ATOM 69 OP2 G A 3 -0.838 -36.534 -0.165 1.00 1.00 O +ATOM 70 O5' G A 3 -3.275 -37.060 0.059 1.00 1.00 O +ATOM 71 C5' G A 3 -4.454 -37.838 -0.160 1.00 1.00 C +ATOM 72 C4' G A 3 -5.676 -37.204 0.508 1.00 1.00 C +ATOM 73 O4' G A 3 -5.510 -37.198 1.921 1.00 1.00 O +ATOM 74 C3' G A 3 -5.937 -35.761 0.102 1.00 1.00 C +ATOM 75 O3' G A 3 -6.791 -35.727 -1.049 1.00 1.00 O +ATOM 76 C2' G A 3 -6.662 -35.186 1.310 1.00 1.00 C +ATOM 77 O2' G A 3 -8.083 -35.277 1.159 1.00 1.00 O +ATOM 78 C1' G A 3 -6.172 -36.050 2.470 1.00 1.00 C +ATOM 79 N9 G A 3 -5.209 -35.370 3.354 1.00 1.00 N +ATOM 80 C8 G A 3 -3.850 -35.253 3.212 1.00 1.00 C +ATOM 81 N7 G A 3 -3.270 -34.610 4.186 1.00 1.00 N +ATOM 82 C5 G A 3 -4.319 -34.273 5.036 1.00 1.00 C +ATOM 83 C6 G A 3 -4.301 -33.562 6.269 1.00 1.00 C +ATOM 84 O6 G A 3 -3.334 -33.085 6.860 1.00 1.00 O +ATOM 85 N1 G A 3 -5.576 -33.438 6.804 1.00 1.00 N +ATOM 86 C2 G A 3 -6.726 -33.934 6.229 1.00 1.00 C +ATOM 87 N2 G A 3 -7.860 -33.712 6.893 1.00 1.00 N +ATOM 88 N3 G A 3 -6.746 -34.604 5.072 1.00 1.00 N +ATOM 89 C4 G A 3 -5.510 -34.734 4.535 1.00 1.00 C +ATOM 90 H5' G A 3 -4.305 -38.837 0.250 1.00 1.00 H +ATOM 91 H5'' G A 3 -4.634 -37.917 -1.232 1.00 1.00 H +ATOM 92 H4' G A 3 -6.554 -37.800 0.269 1.00 1.00 H +ATOM 93 H3' G A 3 -5.000 -35.231 -0.080 1.00 1.00 H +ATOM 94 H2' G A 3 -6.358 -34.151 1.469 1.00 1.00 H +ATOM 95 HO2' G A 3 -8.256 -35.563 0.259 1.00 1.00 H +ATOM 96 H1' G A 3 -7.027 -36.376 3.062 1.00 1.00 H +ATOM 97 H8 G A 3 -3.304 -35.659 2.360 1.00 1.00 H +ATOM 98 H1 G A 3 -5.643 -32.944 7.681 1.00 1.00 H +ATOM 99 H21 G A 3 -7.843 -33.203 7.769 1.00 1.00 H +ATOM 100 H22 G A 3 -8.738 -34.050 6.523 1.00 1.00 H +ATOM 101 P A A 4 -6.732 -34.494 -2.087 1.00 1.00 P +ATOM 102 OP1 A A 4 -7.689 -34.768 -3.181 1.00 1.00 O +ATOM 103 OP2 A A 4 -5.313 -34.222 -2.403 1.00 1.00 O +ATOM 104 O5' A A 4 -7.298 -33.257 -1.222 1.00 1.00 O +ATOM 105 C5' A A 4 -8.705 -33.062 -1.057 1.00 1.00 C +ATOM 106 C4' A A 4 -9.007 -31.772 -0.293 1.00 1.00 C +ATOM 107 O4' A A 4 -8.559 -31.879 1.052 1.00 1.00 O +ATOM 108 C3' A A 4 -8.335 -30.537 -0.863 1.00 1.00 C +ATOM 109 O3' A A 4 -9.164 -29.943 -1.865 1.00 1.00 O +ATOM 110 C2' A A 4 -8.228 -29.612 0.340 1.00 1.00 C +ATOM 111 O2' A A 4 -9.353 -28.728 0.426 1.00 1.00 O +ATOM 112 C1' A A 4 -8.185 -30.578 1.526 1.00 1.00 C +ATOM 113 N9 A A 4 -6.852 -30.705 2.138 1.00 1.00 N +ATOM 114 C8 A A 4 -5.787 -31.460 1.720 1.00 1.00 C +ATOM 115 N7 A A 4 -4.741 -31.372 2.495 1.00 1.00 N +ATOM 116 C5 A A 4 -5.144 -30.496 3.498 1.00 1.00 C +ATOM 117 C6 A A 4 -4.488 -29.988 4.632 1.00 1.00 C +ATOM 118 N6 A A 4 -3.233 -30.306 4.952 1.00 1.00 N +ATOM 119 N1 A A 4 -5.178 -29.141 5.414 1.00 1.00 N +ATOM 120 C2 A A 4 -6.427 -28.828 5.088 1.00 1.00 C +ATOM 121 N3 A A 4 -7.148 -29.237 4.055 1.00 1.00 N +ATOM 122 C4 A A 4 -6.429 -30.085 3.289 1.00 1.00 C +ATOM 123 H5' A A 4 -9.119 -33.907 -0.507 1.00 1.00 H +ATOM 124 H5'' A A 4 -9.177 -33.013 -2.040 1.00 1.00 H +ATOM 125 H4' A A 4 -10.084 -31.614 -0.284 1.00 1.00 H +ATOM 126 H3' A A 4 -7.344 -30.778 -1.255 1.00 1.00 H +ATOM 127 H2' A A 4 -7.295 -29.046 0.293 1.00 1.00 H +ATOM 128 HO2' A A 4 -10.135 -29.239 0.206 1.00 1.00 H +ATOM 129 H1' A A 4 -8.896 -30.253 2.284 1.00 1.00 H +ATOM 130 H8 A A 4 -5.811 -32.078 0.822 1.00 1.00 H +ATOM 131 H61 A A 4 -2.806 -29.909 5.782 1.00 1.00 H +ATOM 132 H62 A A 4 -2.710 -30.940 4.369 1.00 1.00 H +ATOM 133 H2 A A 4 -6.927 -28.137 5.766 1.00 1.00 H +ATOM 134 P U A 5 -8.513 -29.050 -3.037 1.00 1.00 P +ATOM 135 OP1 U A 5 -9.612 -28.442 -3.820 1.00 1.00 O +ATOM 136 OP2 U A 5 -7.483 -29.863 -3.720 1.00 1.00 O +ATOM 137 O5' U A 5 -7.767 -27.877 -2.221 1.00 1.00 O +ATOM 138 C5' U A 5 -8.503 -26.759 -1.719 1.00 1.00 C +ATOM 139 C4' U A 5 -7.652 -25.894 -0.792 1.00 1.00 C +ATOM 140 O4' U A 5 -7.090 -26.691 0.242 1.00 1.00 O +ATOM 141 C3' U A 5 -6.487 -25.199 -1.478 1.00 1.00 C +ATOM 142 O3' U A 5 -6.915 -23.918 -1.949 1.00 1.00 O +ATOM 143 C2' U A 5 -5.471 -25.021 -0.354 1.00 1.00 C +ATOM 144 O2' U A 5 -5.554 -23.710 0.220 1.00 1.00 O +ATOM 145 C1' U A 5 -5.855 -26.101 0.666 1.00 1.00 C +ATOM 146 N1 U A 5 -4.858 -27.188 0.806 1.00 1.00 N +ATOM 147 C2 U A 5 -3.978 -27.112 1.870 1.00 1.00 C +ATOM 148 O2 U A 5 -4.003 -26.183 2.674 1.00 1.00 O +ATOM 149 N3 U A 5 -3.065 -28.146 1.977 1.00 1.00 N +ATOM 150 C4 U A 5 -2.958 -29.234 1.126 1.00 1.00 C +ATOM 151 O4 U A 5 -2.106 -30.097 1.318 1.00 1.00 O +ATOM 152 C5 U A 5 -3.917 -29.231 0.045 1.00 1.00 C +ATOM 153 C6 U A 5 -4.821 -28.229 -0.081 1.00 1.00 C +ATOM 154 H5' U A 5 -9.371 -27.122 -1.168 1.00 1.00 H +ATOM 155 H5'' U A 5 -8.844 -26.152 -2.557 1.00 1.00 H +ATOM 156 H4' U A 5 -8.289 -25.140 -0.334 1.00 1.00 H +ATOM 157 H3' U A 5 -6.080 -25.812 -2.283 1.00 1.00 H +ATOM 158 H2' U A 5 -4.463 -25.213 -0.732 1.00 1.00 H +ATOM 159 HO2' U A 5 -6.392 -23.331 -0.049 1.00 1.00 H +ATOM 160 H1' U A 5 -6.009 -25.629 1.638 1.00 1.00 H +ATOM 161 H3 U A 5 -2.415 -28.104 2.750 1.00 1.00 H +ATOM 162 H5 U A 5 -3.914 -30.045 -0.679 1.00 1.00 H +ATOM 163 H6 U A 5 -5.534 -28.253 -0.906 1.00 1.00 H +ATOM 164 P A A 6 -6.672 -23.469 -3.478 1.00 1.00 P +ATOM 165 OP1 A A 6 -7.254 -24.499 -4.367 1.00 1.00 O +ATOM 166 OP2 A A 6 -5.253 -23.077 -3.628 1.00 1.00 O +ATOM 167 O5' A A 6 -7.577 -22.141 -3.584 1.00 1.00 O +ATOM 168 C5' A A 6 -8.871 -22.106 -2.977 1.00 1.00 C +ATOM 169 C4' A A 6 -8.922 -21.119 -1.812 1.00 1.00 C +ATOM 170 O4' A A 6 -7.735 -21.258 -1.024 1.00 1.00 O +ATOM 171 C3' A A 6 -9.036 -19.658 -2.244 1.00 1.00 C +ATOM 172 O3' A A 6 -10.059 -19.023 -1.469 1.00 1.00 O +ATOM 173 C2' A A 6 -7.682 -19.044 -1.912 1.00 1.00 C +ATOM 174 O2' A A 6 -7.825 -17.717 -1.394 1.00 1.00 O +ATOM 175 C1' A A 6 -7.104 -19.985 -0.865 1.00 1.00 C +ATOM 176 N9 A A 6 -5.645 -20.194 -0.981 1.00 1.00 N +ATOM 177 C8 A A 6 -4.942 -20.824 -1.974 1.00 1.00 C +ATOM 178 N7 A A 6 -3.653 -20.849 -1.775 1.00 1.00 N +ATOM 179 C5 A A 6 -3.491 -20.184 -0.563 1.00 1.00 C +ATOM 180 C6 A A 6 -2.356 -19.872 0.204 1.00 1.00 C +ATOM 181 N6 A A 6 -1.116 -20.209 -0.155 1.00 1.00 N +ATOM 182 N1 A A 6 -2.554 -19.203 1.352 1.00 1.00 N +ATOM 183 C2 A A 6 -3.790 -18.873 1.706 1.00 1.00 C +ATOM 184 N3 A A 6 -4.931 -19.109 1.076 1.00 1.00 N +ATOM 185 C4 A A 6 -4.700 -19.780 -0.073 1.00 1.00 C +ATOM 186 H5' A A 6 -9.120 -23.102 -2.611 1.00 1.00 H +ATOM 187 H5'' A A 6 -9.606 -21.809 -3.724 1.00 1.00 H +ATOM 188 H4' A A 6 -9.778 -21.365 -1.186 1.00 1.00 H +ATOM 189 H3' A A 6 -9.246 -19.581 -3.312 1.00 1.00 H +ATOM 190 H2' A A 6 -7.047 -19.043 -2.801 1.00 1.00 H +ATOM 191 HO2' A A 6 -8.246 -17.187 -2.076 1.00 1.00 H +ATOM 192 H1' A A 6 -7.327 -19.597 0.128 1.00 1.00 H +ATOM 193 H8 A A 6 -5.415 -21.264 -2.853 1.00 1.00 H +ATOM 194 H61 A A 6 -0.337 -19.959 0.435 1.00 1.00 H +ATOM 195 H62 A A 6 -0.957 -20.712 -1.018 1.00 1.00 H +ATOM 196 H2 A A 6 -3.878 -18.331 2.647 1.00 1.00 H +ATOM 197 P U A 7 -10.602 -17.557 -1.858 1.00 1.00 P +ATOM 198 OP1 U A 7 -11.981 -17.698 -2.375 1.00 1.00 O +ATOM 199 OP2 U A 7 -9.571 -16.884 -2.681 1.00 1.00 O +ATOM 200 O5' U A 7 -10.675 -16.820 -0.427 1.00 1.00 O +ATOM 201 C5' U A 7 -9.602 -15.990 0.024 1.00 1.00 C +ATOM 202 C4' U A 7 -9.281 -16.240 1.497 1.00 1.00 C +ATOM 203 O4' U A 7 -9.395 -17.635 1.782 1.00 1.00 O +ATOM 204 C3' U A 7 -7.873 -15.801 1.908 1.00 1.00 C +ATOM 205 O3' U A 7 -7.955 -14.762 2.886 1.00 1.00 O +ATOM 206 C2' U A 7 -7.243 -17.034 2.546 1.00 1.00 C +ATOM 207 O2' U A 7 -6.613 -16.713 3.789 1.00 1.00 O +ATOM 208 C1' U A 7 -8.407 -17.988 2.746 1.00 1.00 C +ATOM 209 N1 U A 7 -8.060 -19.414 2.551 1.00 1.00 N +ATOM 210 C2 U A 7 -9.056 -20.250 2.086 1.00 1.00 C +ATOM 211 O2 U A 7 -10.189 -19.843 1.841 1.00 1.00 O +ATOM 212 N3 U A 7 -8.704 -21.577 1.911 1.00 1.00 N +ATOM 213 C4 U A 7 -7.460 -22.131 2.157 1.00 1.00 C +ATOM 214 O4 U A 7 -7.259 -23.329 1.968 1.00 1.00 O +ATOM 215 C5 U A 7 -6.479 -21.185 2.640 1.00 1.00 C +ATOM 216 C6 U A 7 -6.800 -19.881 2.820 1.00 1.00 C +ATOM 217 H5' U A 7 -9.883 -14.945 -0.106 1.00 1.00 H +ATOM 218 H5'' U A 7 -8.717 -16.199 -0.577 1.00 1.00 H +ATOM 219 H4' U A 7 -10.006 -15.705 2.108 1.00 1.00 H +ATOM 220 H3' U A 7 -7.295 -15.478 1.042 1.00 1.00 H +ATOM 221 H2' U A 7 -6.527 -17.475 1.856 1.00 1.00 H +ATOM 222 HO2' U A 7 -6.765 -17.452 4.384 1.00 1.00 H +ATOM 223 H1' U A 7 -8.815 -17.854 3.746 1.00 1.00 H +ATOM 224 H3 U A 7 -9.424 -22.200 1.573 1.00 1.00 H +ATOM 225 H5 U A 7 -5.468 -21.525 2.863 1.00 1.00 H +ATOM 226 H6 U A 7 -6.041 -19.188 3.184 1.00 1.00 H +ATOM 227 P G A 8 -6.684 -13.815 3.163 1.00 1.00 P +ATOM 228 OP1 G A 8 -6.463 -13.752 4.625 1.00 1.00 O +ATOM 229 OP2 G A 8 -6.854 -12.568 2.386 1.00 1.00 O +ATOM 230 O5' G A 8 -5.474 -14.656 2.507 1.00 1.00 O +ATOM 231 C5' G A 8 -4.518 -15.329 3.334 1.00 1.00 C +ATOM 232 C4' G A 8 -3.102 -15.186 2.774 1.00 1.00 C +ATOM 233 O4' G A 8 -2.774 -16.312 1.956 1.00 1.00 O +ATOM 234 C3' G A 8 -2.916 -13.947 1.921 1.00 1.00 C +ATOM 235 O3' G A 8 -2.385 -12.888 2.721 1.00 1.00 O +ATOM 236 C2' G A 8 -1.897 -14.360 0.872 1.00 1.00 C +ATOM 237 O2' G A 8 -0.576 -13.950 1.239 1.00 1.00 O +ATOM 238 C1' G A 8 -2.020 -15.878 0.812 1.00 1.00 C +ATOM 239 N9 G A 8 -2.731 -16.357 -0.386 1.00 1.00 N +ATOM 240 C8 G A 8 -4.068 -16.621 -0.521 1.00 1.00 C +ATOM 241 N7 G A 8 -4.412 -17.023 -1.711 1.00 1.00 N +ATOM 242 C5 G A 8 -3.217 -17.030 -2.422 1.00 1.00 C +ATOM 243 C6 G A 8 -2.970 -17.380 -3.779 1.00 1.00 C +ATOM 244 O6 G A 8 -3.774 -17.756 -4.629 1.00 1.00 O +ATOM 245 N1 G A 8 -1.626 -17.251 -4.100 1.00 1.00 N +ATOM 246 C2 G A 8 -0.640 -16.836 -3.231 1.00 1.00 C +ATOM 247 N2 G A 8 0.596 -16.778 -3.728 1.00 1.00 N +ATOM 248 N3 G A 8 -0.870 -16.504 -1.954 1.00 1.00 N +ATOM 249 C4 G A 8 -2.179 -16.623 -1.621 1.00 1.00 C +ATOM 250 H5' G A 8 -4.777 -16.385 3.389 1.00 1.00 H +ATOM 251 H5'' G A 8 -4.550 -14.900 4.335 1.00 1.00 H +ATOM 252 H4' G A 8 -2.399 -15.149 3.605 1.00 1.00 H +ATOM 253 H3' G A 8 -3.856 -13.654 1.451 1.00 1.00 H +ATOM 254 H2' G A 8 -2.180 -13.941 -0.091 1.00 1.00 H +ATOM 255 HO2' G A 8 -0.357 -14.392 2.063 1.00 1.00 H +ATOM 256 H1' G A 8 -1.026 -16.324 0.841 1.00 1.00 H +ATOM 257 H8 G A 8 -4.780 -16.511 0.297 1.00 1.00 H +ATOM 258 H1 G A 8 -1.373 -17.481 -5.051 1.00 1.00 H +ATOM 259 H21 G A 8 0.765 -17.028 -4.684 1.00 1.00 H +ATOM 260 H22 G A 8 1.359 -16.486 -3.144 1.00 1.00 H +ATOM 261 P G A 9 -2.441 -11.370 2.192 1.00 1.00 P +ATOM 262 OP1 G A 9 -1.695 -10.519 3.146 1.00 1.00 O +ATOM 263 OP2 G A 9 -3.845 -11.044 1.855 1.00 1.00 O +ATOM 264 O5' G A 9 -1.603 -11.450 0.823 1.00 1.00 O +ATOM 265 C5' G A 9 -2.212 -11.086 -0.417 1.00 1.00 C +ATOM 266 C4' G A 9 -1.177 -10.920 -1.524 1.00 1.00 C +ATOM 267 O4' G A 9 -0.865 -12.197 -2.090 1.00 1.00 O +ATOM 268 C3' G A 9 -1.641 -10.023 -2.663 1.00 1.00 C +ATOM 269 O3' G A 9 -1.163 -8.688 -2.451 1.00 1.00 O +ATOM 270 C2' G A 9 -0.965 -10.624 -3.883 1.00 1.00 C +ATOM 271 O2' G A 9 0.318 -10.034 -4.115 1.00 1.00 O +ATOM 272 C1' G A 9 -0.841 -12.098 -3.521 1.00 1.00 C +ATOM 273 N9 G A 9 -1.937 -12.934 -4.051 1.00 1.00 N +ATOM 274 C8 G A 9 -2.850 -13.697 -3.368 1.00 1.00 C +ATOM 275 N7 G A 9 -3.701 -14.315 -4.137 1.00 1.00 N +ATOM 276 C5 G A 9 -3.327 -13.939 -5.424 1.00 1.00 C +ATOM 277 C6 G A 9 -3.891 -14.300 -6.679 1.00 1.00 C +ATOM 278 O6 G A 9 -4.850 -15.038 -6.902 1.00 1.00 O +ATOM 279 N1 G A 9 -3.214 -13.701 -7.732 1.00 1.00 N +ATOM 280 C2 G A 9 -2.130 -12.858 -7.600 1.00 1.00 C +ATOM 281 N2 G A 9 -1.612 -12.380 -8.731 1.00 1.00 N +ATOM 282 N3 G A 9 -1.600 -12.517 -6.421 1.00 1.00 N +ATOM 283 C4 G A 9 -2.248 -13.093 -5.381 1.00 1.00 C +ATOM 284 H5' G A 9 -2.749 -10.147 -0.287 1.00 1.00 H +ATOM 285 H5'' G A 9 -2.920 -11.864 -0.706 1.00 1.00 H +ATOM 286 H4' G A 9 -0.268 -10.502 -1.095 1.00 1.00 H +ATOM 287 H3' G A 9 -2.726 -10.048 -2.764 1.00 1.00 H +ATOM 288 H2' G A 9 -1.607 -10.513 -4.758 1.00 1.00 H +ATOM 289 HO2' G A 9 0.174 -9.109 -4.326 1.00 1.00 H +ATOM 290 H1' G A 9 0.108 -12.480 -3.892 1.00 1.00 H +ATOM 291 H8 G A 9 -2.862 -13.779 -2.281 1.00 1.00 H +ATOM 292 H1 G A 9 -3.558 -13.909 -8.659 1.00 1.00 H +ATOM 293 H21 G A 9 -2.017 -12.641 -9.622 1.00 1.00 H +ATOM 294 H22 G A 9 -0.817 -11.758 -8.700 1.00 1.00 H +ATOM 295 P A A 10 -2.187 -7.442 -2.408 1.00 1.00 P +ATOM 296 OP1 A A 10 -1.443 -6.254 -1.936 1.00 1.00 O +ATOM 297 OP2 A A 10 -3.411 -7.874 -1.698 1.00 1.00 O +ATOM 298 O5' A A 10 -2.557 -7.215 -3.961 1.00 1.00 O +ATOM 299 C5' A A 10 -1.739 -6.373 -4.778 1.00 1.00 C +ATOM 300 C4' A A 10 -2.015 -6.569 -6.270 1.00 1.00 C +ATOM 301 O4' A A 10 -1.948 -7.952 -6.600 1.00 1.00 O +ATOM 302 C3' A A 10 -3.382 -6.095 -6.739 1.00 1.00 C +ATOM 303 O3' A A 10 -3.317 -4.719 -7.131 1.00 1.00 O +ATOM 304 C2' A A 10 -3.651 -6.957 -7.962 1.00 1.00 C +ATOM 305 O2' A A 10 -3.280 -6.284 -9.170 1.00 1.00 O +ATOM 306 C1' A A 10 -2.795 -8.197 -7.731 1.00 1.00 C +ATOM 307 N9 A A 10 -3.584 -9.407 -7.463 1.00 1.00 N +ATOM 308 C8 A A 10 -3.916 -9.982 -6.263 1.00 1.00 C +ATOM 309 N7 A A 10 -4.628 -11.068 -6.376 1.00 1.00 N +ATOM 310 C5 A A 10 -4.781 -11.224 -7.750 1.00 1.00 C +ATOM 311 C6 A A 10 -5.440 -12.191 -8.529 1.00 1.00 C +ATOM 312 N6 A A 10 -6.096 -13.227 -8.004 1.00 1.00 N +ATOM 313 N1 A A 10 -5.395 -12.043 -9.864 1.00 1.00 N +ATOM 314 C2 A A 10 -4.739 -11.010 -10.379 1.00 1.00 C +ATOM 315 N3 A A 10 -4.084 -10.041 -9.757 1.00 1.00 N +ATOM 316 C4 A A 10 -4.148 -10.216 -8.420 1.00 1.00 C +ATOM 317 H5' A A 10 -0.691 -6.600 -4.579 1.00 1.00 H +ATOM 318 H5'' A A 10 -1.931 -5.332 -4.518 1.00 1.00 H +ATOM 319 H4' A A 10 -1.249 -6.047 -6.839 1.00 1.00 H +ATOM 320 H3' A A 10 -4.141 -6.258 -5.971 1.00 1.00 H +ATOM 321 H2' A A 10 -4.705 -7.241 -7.989 1.00 1.00 H +ATOM 322 HO2' A A 10 -2.330 -6.381 -9.271 1.00 1.00 H +ATOM 323 H1' A A 10 -2.173 -8.369 -8.610 1.00 1.00 H +ATOM 324 H8 A A 10 -3.611 -9.568 -5.301 1.00 1.00 H +ATOM 325 H61 A A 10 -6.553 -13.891 -8.619 1.00 1.00 H +ATOM 326 H62 A A 10 -6.137 -13.348 -7.003 1.00 1.00 H +ATOM 327 H2 A A 10 -4.742 -10.951 -11.468 1.00 1.00 H +ATOM 328 P A A 11 -4.665 -3.886 -7.436 1.00 1.00 P +ATOM 329 OP1 A A 11 -4.313 -2.451 -7.513 1.00 1.00 O +ATOM 330 OP2 A A 11 -5.712 -4.339 -6.494 1.00 1.00 O +ATOM 331 O5' A A 11 -5.072 -4.384 -8.914 1.00 1.00 O +ATOM 332 C5' A A 11 -4.238 -4.087 -10.037 1.00 1.00 C +ATOM 333 C4' A A 11 -4.788 -4.692 -11.330 1.00 1.00 C +ATOM 334 O4' A A 11 -4.861 -6.113 -11.209 1.00 1.00 O +ATOM 335 C3' A A 11 -6.184 -4.222 -11.707 1.00 1.00 C +ATOM 336 O3' A A 11 -6.101 -3.043 -12.515 1.00 1.00 O +ATOM 337 C2' A A 11 -6.712 -5.386 -12.526 1.00 1.00 C +ATOM 338 O2' A A 11 -6.333 -5.281 -13.902 1.00 1.00 O +ATOM 339 C1' A A 11 -6.049 -6.582 -11.862 1.00 1.00 C +ATOM 340 N9 A A 11 -6.892 -7.235 -10.844 1.00 1.00 N +ATOM 341 C8 A A 11 -6.983 -6.975 -9.500 1.00 1.00 C +ATOM 342 N7 A A 11 -7.814 -7.756 -8.867 1.00 1.00 N +ATOM 343 C5 A A 11 -8.309 -8.593 -9.863 1.00 1.00 C +ATOM 344 C6 A A 11 -9.237 -9.648 -9.844 1.00 1.00 C +ATOM 345 N6 A A 11 -9.855 -10.056 -8.736 1.00 1.00 N +ATOM 346 N1 A A 11 -9.497 -10.261 -11.011 1.00 1.00 N +ATOM 347 C2 A A 11 -8.878 -9.851 -12.112 1.00 1.00 C +ATOM 348 N3 A A 11 -7.991 -8.877 -12.258 1.00 1.00 N +ATOM 349 C4 A A 11 -7.751 -8.281 -11.070 1.00 1.00 C +ATOM 350 H5' A A 11 -3.240 -4.487 -9.855 1.00 1.00 H +ATOM 351 H5'' A A 11 -4.170 -3.006 -10.151 1.00 1.00 H +ATOM 352 H4' A A 11 -4.105 -4.454 -12.145 1.00 1.00 H +ATOM 353 H3' A A 11 -6.798 -4.059 -10.817 1.00 1.00 H +ATOM 354 H2' A A 11 -7.794 -5.461 -12.428 1.00 1.00 H +ATOM 355 HO2' A A 11 -6.747 -6.013 -14.369 1.00 1.00 H +ATOM 356 H1' A A 11 -5.778 -7.313 -12.622 1.00 1.00 H +ATOM 357 H8 A A 11 -6.414 -6.187 -9.006 1.00 1.00 H +ATOM 358 H61 A A 11 -10.513 -10.817 -8.778 1.00 1.00 H +ATOM 359 H62 A A 11 -9.666 -9.600 -7.855 1.00 1.00 H +ATOM 360 H2 A A 11 -9.135 -10.391 -13.022 1.00 1.00 H +ATOM 361 P G A 12 -7.048 -1.771 -12.220 1.00 1.00 P +ATOM 362 OP1 G A 12 -6.655 -0.682 -13.143 1.00 1.00 O +ATOM 363 OP2 G A 12 -7.058 -1.531 -10.760 1.00 1.00 O +ATOM 364 O5' G A 12 -8.508 -2.295 -12.656 1.00 1.00 O +ATOM 365 C5' G A 12 -8.906 -2.269 -14.030 1.00 1.00 C +ATOM 366 C4' G A 12 -10.296 -2.868 -14.234 1.00 1.00 C +ATOM 367 O4' G A 12 -10.277 -4.266 -13.969 1.00 1.00 O +ATOM 368 C3' G A 12 -11.383 -2.279 -13.347 1.00 1.00 C +ATOM 369 O3' G A 12 -11.975 -1.146 -13.996 1.00 1.00 O +ATOM 370 C2' G A 12 -12.397 -3.405 -13.261 1.00 1.00 C +ATOM 371 O2' G A 12 -13.403 -3.286 -14.270 1.00 1.00 O +ATOM 372 C1' G A 12 -11.555 -4.658 -13.448 1.00 1.00 C +ATOM 373 N9 G A 12 -11.344 -5.416 -12.207 1.00 1.00 N +ATOM 374 C8 G A 12 -10.334 -5.307 -11.287 1.00 1.00 C +ATOM 375 N7 G A 12 -10.431 -6.147 -10.293 1.00 1.00 N +ATOM 376 C5 G A 12 -11.591 -6.863 -10.572 1.00 1.00 C +ATOM 377 C6 G A 12 -12.209 -7.917 -9.843 1.00 1.00 C +ATOM 378 O6 G A 12 -11.844 -8.433 -8.789 1.00 1.00 O +ATOM 379 N1 G A 12 -13.365 -8.362 -10.472 1.00 1.00 N +ATOM 380 C2 G A 12 -13.866 -7.859 -11.653 1.00 1.00 C +ATOM 381 N2 G A 12 -14.991 -8.414 -12.101 1.00 1.00 N +ATOM 382 N3 G A 12 -13.286 -6.869 -12.341 1.00 1.00 N +ATOM 383 C4 G A 12 -12.157 -6.422 -11.742 1.00 1.00 C +ATOM 384 H5' G A 12 -8.185 -2.840 -14.616 1.00 1.00 H +ATOM 385 H5'' G A 12 -8.908 -1.237 -14.381 1.00 1.00 H +ATOM 386 H4' G A 12 -10.583 -2.727 -15.273 1.00 1.00 H +ATOM 387 H3' G A 12 -10.993 -2.020 -12.361 1.00 1.00 H +ATOM 388 H2' G A 12 -12.844 -3.423 -12.268 1.00 1.00 H +ATOM 389 HO2' G A 12 -14.040 -2.637 -13.961 1.00 1.00 H +ATOM 390 H1' G A 12 -12.046 -5.305 -14.174 1.00 1.00 H +ATOM 391 H8 G A 12 -9.522 -4.585 -11.377 1.00 1.00 H +ATOM 392 H1 G A 12 -13.860 -9.113 -10.012 1.00 1.00 H +ATOM 393 H21 G A 12 -15.428 -9.157 -11.582 1.00 1.00 H +ATOM 394 H22 G A 12 -15.408 -8.086 -12.962 1.00 1.00 H +ATOM 395 P A A 13 -12.826 -0.063 -13.158 1.00 1.00 P +ATOM 396 OP1 A A 13 -12.895 1.181 -13.958 1.00 1.00 O +ATOM 397 OP2 A A 13 -12.291 -0.021 -11.779 1.00 1.00 O +ATOM 398 O5' A A 13 -14.302 -0.714 -13.109 1.00 1.00 O +ATOM 399 C5' A A 13 -15.096 -0.814 -14.295 1.00 1.00 C +ATOM 400 C4' A A 13 -16.203 -1.866 -14.161 1.00 1.00 C +ATOM 401 O4' A A 13 -15.644 -3.118 -13.761 1.00 1.00 O +ATOM 402 C3' A A 13 -17.280 -1.533 -13.138 1.00 1.00 C +ATOM 403 O3' A A 13 -18.321 -0.766 -13.757 1.00 1.00 O +ATOM 404 C2' A A 13 -17.804 -2.907 -12.752 1.00 1.00 C +ATOM 405 O2' A A 13 -18.849 -3.334 -13.633 1.00 1.00 O +ATOM 406 C1' A A 13 -16.565 -3.792 -12.889 1.00 1.00 C +ATOM 407 N9 A A 13 -15.868 -4.040 -11.621 1.00 1.00 N +ATOM 408 C8 A A 13 -14.975 -3.244 -10.951 1.00 1.00 C +ATOM 409 N7 A A 13 -14.523 -3.771 -9.847 1.00 1.00 N +ATOM 410 C5 A A 13 -15.162 -5.006 -9.781 1.00 1.00 C +ATOM 411 C6 A A 13 -15.113 -6.052 -8.845 1.00 1.00 C +ATOM 412 N6 A A 13 -14.356 -6.016 -7.747 1.00 1.00 N +ATOM 413 N1 A A 13 -15.875 -7.133 -9.088 1.00 1.00 N +ATOM 414 C2 A A 13 -16.626 -7.163 -10.182 1.00 1.00 C +ATOM 415 N3 A A 13 -16.759 -6.248 -11.130 1.00 1.00 N +ATOM 416 C4 A A 13 -15.983 -5.177 -10.858 1.00 1.00 C +ATOM 417 H5' A A 13 -14.450 -1.085 -15.130 1.00 1.00 H +ATOM 418 H5'' A A 13 -15.549 0.156 -14.501 1.00 1.00 H +ATOM 419 H4' A A 13 -16.674 -2.000 -15.133 1.00 1.00 H +ATOM 420 H3' A A 13 -16.857 -1.017 -12.274 1.00 1.00 H +ATOM 421 H2' A A 13 -18.148 -2.901 -11.716 1.00 1.00 H +ATOM 422 HO2' A A 13 -19.064 -4.243 -13.404 1.00 1.00 H +ATOM 423 H1' A A 13 -16.847 -4.751 -13.328 1.00 1.00 H +ATOM 424 H8 A A 13 -14.671 -2.259 -11.308 1.00 1.00 H +ATOM 425 H61 A A 13 -14.362 -6.811 -7.106 1.00 1.00 H +ATOM 426 H62 A A 13 -13.780 -5.213 -7.553 1.00 1.00 H +ATOM 427 H2 A A 13 -17.220 -8.068 -10.316 1.00 1.00 H +ATOM 428 P A A 14 -18.930 0.541 -13.029 1.00 1.00 P +ATOM 429 OP1 A A 14 -19.885 1.182 -13.961 1.00 1.00 O +ATOM 430 OP2 A A 14 -17.806 1.325 -12.473 1.00 1.00 O +ATOM 431 O5' A A 14 -19.765 -0.079 -11.799 1.00 1.00 O +ATOM 432 C5' A A 14 -21.087 -0.586 -12.002 1.00 1.00 C +ATOM 433 C4' A A 14 -21.601 -1.335 -10.773 1.00 1.00 C +ATOM 434 O4' A A 14 -20.801 -2.489 -10.535 1.00 1.00 O +ATOM 435 C3' A A 14 -21.578 -0.530 -9.483 1.00 1.00 C +ATOM 436 O3' A A 14 -22.801 0.205 -9.344 1.00 1.00 O +ATOM 437 C2' A A 14 -21.495 -1.612 -8.420 1.00 1.00 C +ATOM 438 O2' A A 14 -22.800 -2.063 -8.036 1.00 1.00 O +ATOM 439 C1' A A 14 -20.703 -2.716 -9.120 1.00 1.00 C +ATOM 440 N9 A A 14 -19.271 -2.735 -8.774 1.00 1.00 N +ATOM 441 C8 A A 14 -18.248 -1.999 -9.315 1.00 1.00 C +ATOM 442 N7 A A 14 -17.078 -2.265 -8.801 1.00 1.00 N +ATOM 443 C5 A A 14 -17.347 -3.247 -7.852 1.00 1.00 C +ATOM 444 C6 A A 14 -16.525 -3.955 -6.959 1.00 1.00 C +ATOM 445 N6 A A 14 -15.207 -3.769 -6.876 1.00 1.00 N +ATOM 446 N1 A A 14 -17.118 -4.857 -6.159 1.00 1.00 N +ATOM 447 C2 A A 14 -18.430 -5.038 -6.247 1.00 1.00 C +ATOM 448 N3 A A 14 -19.305 -4.438 -7.041 1.00 1.00 N +ATOM 449 C4 A A 14 -18.680 -3.540 -7.830 1.00 1.00 C +ATOM 450 H5' A A 14 -21.078 -1.267 -12.853 1.00 1.00 H +ATOM 451 H5'' A A 14 -21.759 0.245 -12.219 1.00 1.00 H +ATOM 452 H4' A A 14 -22.621 -1.662 -10.964 1.00 1.00 H +ATOM 453 H3' A A 14 -20.707 0.126 -9.443 1.00 1.00 H +ATOM 454 H2' A A 14 -20.941 -1.248 -7.556 1.00 1.00 H +ATOM 455 HO2' A A 14 -22.766 -3.021 -7.981 1.00 1.00 H +ATOM 456 H1' A A 14 -21.141 -3.684 -8.880 1.00 1.00 H +ATOM 457 H8 A A 14 -18.397 -1.257 -10.100 1.00 1.00 H +ATOM 458 H61 A A 14 -14.664 -4.306 -6.215 1.00 1.00 H +ATOM 459 H62 A A 14 -14.753 -3.093 -7.473 1.00 1.00 H +ATOM 460 H2 A A 14 -18.846 -5.783 -5.570 1.00 1.00 H +ATOM 461 P C A 15 -22.820 1.659 -8.646 1.00 1.00 P +ATOM 462 OP1 C A 15 -24.211 2.163 -8.670 1.00 1.00 O +ATOM 463 OP2 C A 15 -21.732 2.469 -9.237 1.00 1.00 O +ATOM 464 O5' C A 15 -22.429 1.334 -7.116 1.00 1.00 O +ATOM 465 C5' C A 15 -23.405 0.826 -6.202 1.00 1.00 C +ATOM 466 C4' C A 15 -22.780 0.452 -4.860 1.00 1.00 C +ATOM 467 O4' C A 15 -21.867 -0.624 -5.022 1.00 1.00 O +ATOM 468 C3' C A 15 -21.991 1.566 -4.197 1.00 1.00 C +ATOM 469 O3' C A 15 -22.867 2.379 -3.407 1.00 1.00 O +ATOM 470 C2' C A 15 -21.021 0.812 -3.299 1.00 1.00 C +ATOM 471 O2' C A 15 -21.528 0.681 -1.967 1.00 1.00 O +ATOM 472 C1' C A 15 -20.884 -0.553 -3.979 1.00 1.00 C +ATOM 473 N1 C A 15 -19.557 -0.779 -4.594 1.00 1.00 N +ATOM 474 C2 C A 15 -18.649 -1.554 -3.892 1.00 1.00 C +ATOM 475 O2 C A 15 -18.957 -2.028 -2.800 1.00 1.00 O +ATOM 476 N3 C A 15 -17.421 -1.770 -4.443 1.00 1.00 N +ATOM 477 C4 C A 15 -17.102 -1.246 -5.635 1.00 1.00 C +ATOM 478 N4 C A 15 -15.892 -1.475 -6.147 1.00 1.00 N +ATOM 479 C5 C A 15 -18.038 -0.447 -6.362 1.00 1.00 C +ATOM 480 C6 C A 15 -19.248 -0.240 -5.808 1.00 1.00 C +ATOM 481 H5' C A 15 -23.869 -0.060 -6.637 1.00 1.00 H +ATOM 482 H5'' C A 15 -24.171 1.584 -6.039 1.00 1.00 H +ATOM 483 H4' C A 15 -23.569 0.130 -4.184 1.00 1.00 H +ATOM 484 H3' C A 15 -21.454 2.158 -4.938 1.00 1.00 H +ATOM 485 H2' C A 15 -20.055 1.314 -3.295 1.00 1.00 H +ATOM 486 HO2' C A 15 -20.774 0.708 -1.372 1.00 1.00 H +ATOM 487 H1' C A 15 -21.082 -1.335 -3.250 1.00 1.00 H +ATOM 488 H41 C A 15 -15.226 -2.038 -5.639 1.00 1.00 H +ATOM 489 H42 C A 15 -15.642 -1.084 -7.044 1.00 1.00 H +ATOM 490 H5 C A 15 -17.781 -0.021 -7.333 1.00 1.00 H +ATOM 491 H6 C A 15 -19.986 0.365 -6.335 1.00 1.00 H +ATOM 492 P C A 16 -22.449 3.880 -2.997 1.00 1.00 P +ATOM 493 OP1 C A 16 -23.597 4.502 -2.299 1.00 1.00 O +ATOM 494 OP2 C A 16 -21.862 4.541 -4.184 1.00 1.00 O +ATOM 495 O5' C A 16 -21.276 3.635 -1.919 1.00 1.00 O +ATOM 496 C5' C A 16 -21.563 2.968 -0.686 1.00 1.00 C +ATOM 497 C4' C A 16 -20.307 2.393 -0.035 1.00 1.00 C +ATOM 498 O4' C A 16 -19.595 1.590 -0.967 1.00 1.00 O +ATOM 499 C3' C A 16 -19.318 3.431 0.470 1.00 1.00 C +ATOM 500 O3' C A 16 -19.613 3.755 1.833 1.00 1.00 O +ATOM 501 C2' C A 16 -17.982 2.713 0.405 1.00 1.00 C +ATOM 502 O2' C A 16 -17.610 2.188 1.685 1.00 1.00 O +ATOM 503 C1' C A 16 -18.208 1.596 -0.610 1.00 1.00 C +ATOM 504 N1 C A 16 -17.403 1.728 -1.846 1.00 1.00 N +ATOM 505 C2 C A 16 -16.224 1.002 -1.908 1.00 1.00 C +ATOM 506 O2 C A 16 -15.878 0.308 -0.954 1.00 1.00 O +ATOM 507 N3 C A 16 -15.474 1.083 -3.041 1.00 1.00 N +ATOM 508 C4 C A 16 -15.864 1.846 -4.071 1.00 1.00 C +ATOM 509 N4 C A 16 -15.106 1.900 -5.166 1.00 1.00 N +ATOM 510 C5 C A 16 -17.078 2.598 -4.011 1.00 1.00 C +ATOM 511 C6 C A 16 -17.814 2.512 -2.885 1.00 1.00 C +ATOM 512 H5' C A 16 -22.264 2.157 -0.881 1.00 1.00 H +ATOM 513 H5'' C A 16 -22.024 3.676 0.001 1.00 1.00 H +ATOM 514 H4' C A 16 -20.606 1.761 0.799 1.00 1.00 H +ATOM 515 H3' C A 16 -19.319 4.319 -0.163 1.00 1.00 H +ATOM 516 H2' C A 16 -17.216 3.398 0.036 1.00 1.00 H +ATOM 517 HO2' C A 16 -17.600 1.231 1.608 1.00 1.00 H +ATOM 518 H1' C A 16 -17.971 0.644 -0.131 1.00 1.00 H +ATOM 519 H41 C A 16 -14.250 1.370 -5.213 1.00 1.00 H +ATOM 520 H42 C A 16 -15.391 2.472 -5.947 1.00 1.00 H +ATOM 521 H5 C A 16 -17.398 3.221 -4.848 1.00 1.00 H +ATOM 522 H6 C A 16 -18.743 3.075 -2.802 1.00 1.00 H +ATOM 523 P G A 17 -18.830 4.947 2.581 1.00 1.00 P +ATOM 524 OP1 G A 17 -19.668 5.420 3.705 1.00 1.00 O +ATOM 525 OP2 G A 17 -18.358 5.907 1.559 1.00 1.00 O +ATOM 526 O5' G A 17 -17.541 4.189 3.195 1.00 1.00 O +ATOM 527 C5' G A 17 -17.691 3.212 4.232 1.00 1.00 C +ATOM 528 C4' G A 17 -16.341 2.656 4.698 1.00 1.00 C +ATOM 529 O4' G A 17 -15.769 1.820 3.699 1.00 1.00 O +ATOM 530 C3' G A 17 -15.302 3.715 5.016 1.00 1.00 C +ATOM 531 O3' G A 17 -15.412 4.095 6.391 1.00 1.00 O +ATOM 532 C2' G A 17 -13.978 3.007 4.771 1.00 1.00 C +ATOM 533 O2' G A 17 -13.421 2.493 5.987 1.00 1.00 O +ATOM 534 C1' G A 17 -14.339 1.883 3.801 1.00 1.00 C +ATOM 535 N9 G A 17 -13.813 2.088 2.445 1.00 1.00 N +ATOM 536 C8 G A 17 -14.512 2.317 1.289 1.00 1.00 C +ATOM 537 N7 G A 17 -13.757 2.476 0.238 1.00 1.00 N +ATOM 538 C5 G A 17 -12.463 2.342 0.731 1.00 1.00 C +ATOM 539 C6 G A 17 -11.218 2.420 0.049 1.00 1.00 C +ATOM 540 O6 G A 17 -11.012 2.626 -1.146 1.00 1.00 O +ATOM 541 N1 G A 17 -10.150 2.229 0.915 1.00 1.00 N +ATOM 542 C2 G A 17 -10.261 1.993 2.269 1.00 1.00 C +ATOM 543 N2 G A 17 -9.118 1.838 2.935 1.00 1.00 N +ATOM 544 N3 G A 17 -11.432 1.919 2.912 1.00 1.00 N +ATOM 545 C4 G A 17 -12.487 2.103 2.083 1.00 1.00 C +ATOM 546 H5' G A 17 -18.302 2.389 3.857 1.00 1.00 H +ATOM 547 H5'' G A 17 -18.197 3.669 5.083 1.00 1.00 H +ATOM 548 H4' G A 17 -16.506 2.053 5.589 1.00 1.00 H +ATOM 549 H3' G A 17 -15.410 4.577 4.355 1.00 1.00 H +ATOM 550 H2' G A 17 -13.279 3.692 4.288 1.00 1.00 H +ATOM 551 HO2' G A 17 -14.015 1.812 6.309 1.00 1.00 H +ATOM 552 H1' G A 17 -13.963 0.938 4.191 1.00 1.00 H +ATOM 553 H8 G A 17 -15.601 2.363 1.251 1.00 1.00 H +ATOM 554 H1 G A 17 -9.229 2.270 0.502 1.00 1.00 H +ATOM 555 H21 G A 17 -8.235 1.895 2.446 1.00 1.00 H +ATOM 556 H22 G A 17 -9.133 1.662 3.929 1.00 1.00 H +ATOM 557 P G A 18 -14.748 5.463 6.918 1.00 1.00 P +ATOM 558 OP1 G A 18 -15.224 5.701 8.299 1.00 1.00 O +ATOM 559 OP2 G A 18 -14.938 6.501 5.882 1.00 1.00 O +ATOM 560 O5' G A 18 -13.182 5.094 6.980 1.00 1.00 O +ATOM 561 C5' G A 18 -12.714 4.068 7.860 1.00 1.00 C +ATOM 562 C4' G A 18 -11.224 3.797 7.671 1.00 1.00 C +ATOM 563 O4' G A 18 -10.965 3.410 6.321 1.00 1.00 O +ATOM 564 C3' G A 18 -10.334 4.994 7.963 1.00 1.00 C +ATOM 565 O3' G A 18 -9.917 4.946 9.332 1.00 1.00 O +ATOM 566 C2' G A 18 -9.140 4.788 7.044 1.00 1.00 C +ATOM 567 O2' G A 18 -8.081 4.098 7.716 1.00 1.00 O +ATOM 568 C1' G A 18 -9.707 3.955 5.896 1.00 1.00 C +ATOM 569 N9 G A 18 -9.958 4.728 4.665 1.00 1.00 N +ATOM 570 C8 G A 18 -11.098 5.394 4.295 1.00 1.00 C +ATOM 571 N7 G A 18 -11.012 5.985 3.136 1.00 1.00 N +ATOM 572 C5 G A 18 -9.722 5.690 2.703 1.00 1.00 C +ATOM 573 C6 G A 18 -9.057 6.066 1.504 1.00 1.00 C +ATOM 574 O6 G A 18 -9.486 6.746 0.573 1.00 1.00 O +ATOM 575 N1 G A 18 -7.764 5.561 1.458 1.00 1.00 N +ATOM 576 C2 G A 18 -7.182 4.790 2.442 1.00 1.00 C +ATOM 577 N2 G A 18 -5.929 4.397 2.218 1.00 1.00 N +ATOM 578 N3 G A 18 -7.806 4.436 3.571 1.00 1.00 N +ATOM 579 C4 G A 18 -9.069 4.920 3.633 1.00 1.00 C +ATOM 580 H5' G A 18 -13.270 3.152 7.664 1.00 1.00 H +ATOM 581 H5'' G A 18 -12.891 4.377 8.891 1.00 1.00 H +ATOM 582 H4' G A 18 -10.932 2.977 8.322 1.00 1.00 H +ATOM 583 H3' G A 18 -10.849 5.929 7.735 1.00 1.00 H +ATOM 584 H2' G A 18 -8.793 5.749 6.664 1.00 1.00 H +ATOM 585 HO2' G A 18 -7.802 3.378 7.146 1.00 1.00 H +ATOM 586 H1' G A 18 -9.020 3.140 5.671 1.00 1.00 H +ATOM 587 H8 G A 18 -11.994 5.426 4.913 1.00 1.00 H +ATOM 588 H1 G A 18 -7.228 5.787 0.633 1.00 1.00 H +ATOM 589 H21 G A 18 -5.461 4.666 1.365 1.00 1.00 H +ATOM 590 H22 G A 18 -5.448 3.830 2.902 1.00 1.00 H +ATOM 591 P G A 19 -9.487 6.286 10.117 1.00 1.00 P +ATOM 592 OP1 G A 19 -9.278 5.940 11.540 1.00 1.00 O +ATOM 593 OP2 G A 19 -10.435 7.361 9.749 1.00 1.00 O +ATOM 594 O5' G A 19 -8.057 6.635 9.466 1.00 1.00 O +ATOM 595 C5' G A 19 -6.965 5.718 9.577 1.00 1.00 C +ATOM 596 C4' G A 19 -5.781 6.156 8.722 1.00 1.00 C +ATOM 597 O4' G A 19 -6.141 6.119 7.346 1.00 1.00 O +ATOM 598 C3' G A 19 -5.299 7.566 9.009 1.00 1.00 C +ATOM 599 O3' G A 19 -4.258 7.522 9.990 1.00 1.00 O +ATOM 600 C2' G A 19 -4.741 8.041 7.675 1.00 1.00 C +ATOM 601 O2' G A 19 -3.323 7.862 7.612 1.00 1.00 O +ATOM 602 C1' G A 19 -5.459 7.165 6.644 1.00 1.00 C +ATOM 603 N9 G A 19 -6.468 7.885 5.846 1.00 1.00 N +ATOM 604 C8 G A 19 -7.769 8.171 6.171 1.00 1.00 C +ATOM 605 N7 G A 19 -8.415 8.824 5.245 1.00 1.00 N +ATOM 606 C5 G A 19 -7.475 8.983 4.230 1.00 1.00 C +ATOM 607 C6 G A 19 -7.601 9.620 2.964 1.00 1.00 C +ATOM 608 O6 G A 19 -8.586 10.178 2.485 1.00 1.00 O +ATOM 609 N1 G A 19 -6.415 9.560 2.244 1.00 1.00 N +ATOM 610 C2 G A 19 -5.252 8.963 2.682 1.00 1.00 C +ATOM 611 N2 G A 19 -4.215 9.007 1.847 1.00 1.00 N +ATOM 612 N3 G A 19 -5.132 8.363 3.872 1.00 1.00 N +ATOM 613 C4 G A 19 -6.279 8.412 4.589 1.00 1.00 C +ATOM 614 H5' G A 19 -7.294 4.731 9.253 1.00 1.00 H +ATOM 615 H5'' G A 19 -6.651 5.664 10.620 1.00 1.00 H +ATOM 616 H4' G A 19 -4.957 5.462 8.878 1.00 1.00 H +ATOM 617 H3' G A 19 -6.126 8.201 9.334 1.00 1.00 H +ATOM 618 H2' G A 19 -5.004 9.090 7.516 1.00 1.00 H +ATOM 619 HO2' G A 19 -2.919 8.700 7.850 1.00 1.00 H +ATOM 620 H1' G A 19 -4.722 6.726 5.972 1.00 1.00 H +ATOM 621 H8 G A 19 -8.224 7.879 7.117 1.00 1.00 H +ATOM 622 H1 G A 19 -6.427 9.994 1.332 1.00 1.00 H +ATOM 623 H21 G A 19 -4.309 9.460 0.951 1.00 1.00 H +ATOM 624 H22 G A 19 -3.336 8.586 2.111 1.00 1.00 H +ATOM 625 P G A 20 -4.088 8.713 11.060 1.00 1.00 P +ATOM 626 OP1 G A 20 -3.051 8.312 12.037 1.00 1.00 O +ATOM 627 OP2 G A 20 -5.434 9.107 11.532 1.00 1.00 O +ATOM 628 O5' G A 20 -3.499 9.914 10.166 1.00 1.00 O +ATOM 629 C5' G A 20 -3.854 11.266 10.454 1.00 1.00 C +ATOM 630 C4' G A 20 -3.568 12.190 9.274 1.00 1.00 C +ATOM 631 O4' G A 20 -3.965 11.556 8.055 1.00 1.00 O +ATOM 632 C3' G A 20 -4.291 13.526 9.352 1.00 1.00 C +ATOM 633 O3' G A 20 -3.406 14.514 9.891 1.00 1.00 O +ATOM 634 C2' G A 20 -4.612 13.854 7.901 1.00 1.00 C +ATOM 635 O2' G A 20 -3.589 14.666 7.314 1.00 1.00 O +ATOM 636 C1' G A 20 -4.687 12.483 7.234 1.00 1.00 C +ATOM 637 N9 G A 20 -6.056 11.959 7.091 1.00 1.00 N +ATOM 638 C8 G A 20 -6.804 11.274 8.014 1.00 1.00 C +ATOM 639 N7 G A 20 -7.995 10.953 7.598 1.00 1.00 N +ATOM 640 C5 G A 20 -8.047 11.458 6.302 1.00 1.00 C +ATOM 641 C6 G A 20 -9.101 11.412 5.350 1.00 1.00 C +ATOM 642 O6 G A 20 -10.215 10.908 5.470 1.00 1.00 O +ATOM 643 N1 G A 20 -8.745 12.040 4.165 1.00 1.00 N +ATOM 644 C2 G A 20 -7.529 12.639 3.921 1.00 1.00 C +ATOM 645 N2 G A 20 -7.377 13.188 2.717 1.00 1.00 N +ATOM 646 N3 G A 20 -6.533 12.686 4.815 1.00 1.00 N +ATOM 647 C4 G A 20 -6.863 12.077 5.981 1.00 1.00 C +ATOM 648 H5' G A 20 -3.283 11.606 11.318 1.00 1.00 H +ATOM 649 H5'' G A 20 -4.916 11.310 10.693 1.00 1.00 H +ATOM 650 H4' G A 20 -2.496 12.375 9.229 1.00 1.00 H +ATOM 651 H3' G A 20 -5.204 13.444 9.944 1.00 1.00 H +ATOM 652 H2' G A 20 -5.584 14.351 7.840 1.00 1.00 H +ATOM 653 HO2' G A 20 -2.863 14.084 7.081 1.00 1.00 H +ATOM 654 H1' G A 20 -4.220 12.535 6.251 1.00 1.00 H +ATOM 655 H8 G A 20 -6.433 11.019 9.007 1.00 1.00 H +ATOM 656 H1 G A 20 -9.446 12.047 3.438 1.00 1.00 H +ATOM 657 H21 G A 20 -8.131 13.150 2.045 1.00 1.00 H +ATOM 658 H22 G A 20 -6.512 13.640 2.476 1.00 1.00 H +ATOM 659 P A A 21 -3.904 15.526 11.041 1.00 1.00 P +ATOM 660 OP1 A A 21 -2.720 16.225 11.587 1.00 1.00 O +ATOM 661 OP2 A A 21 -4.809 14.786 11.950 1.00 1.00 O +ATOM 662 O5' A A 21 -4.782 16.594 10.218 1.00 1.00 O +ATOM 663 C5' A A 21 -5.836 17.317 10.860 1.00 1.00 C +ATOM 664 C4' A A 21 -6.364 18.441 9.974 1.00 1.00 C +ATOM 665 O4' A A 21 -5.370 19.467 9.863 1.00 1.00 O +ATOM 666 C3' A A 21 -6.731 17.991 8.562 1.00 1.00 C +ATOM 667 O3' A A 21 -8.155 17.910 8.446 1.00 1.00 O +ATOM 668 C2' A A 21 -6.208 19.101 7.662 1.00 1.00 C +ATOM 669 O2' A A 21 -7.234 20.053 7.361 1.00 1.00 O +ATOM 670 C1' A A 21 -5.091 19.730 8.483 1.00 1.00 C +ATOM 671 N9 A A 21 -3.750 19.193 8.189 1.00 1.00 N +ATOM 672 C8 A A 21 -3.023 18.269 8.894 1.00 1.00 C +ATOM 673 N7 A A 21 -1.864 17.993 8.362 1.00 1.00 N +ATOM 674 C5 A A 21 -1.822 18.793 7.224 1.00 1.00 C +ATOM 675 C6 A A 21 -0.853 18.969 6.221 1.00 1.00 C +ATOM 676 N6 A A 21 0.308 18.314 6.204 1.00 1.00 N +ATOM 677 N1 A A 21 -1.134 19.842 5.240 1.00 1.00 N +ATOM 678 C2 A A 21 -2.294 20.489 5.261 1.00 1.00 C +ATOM 679 N3 A A 21 -3.278 20.411 6.142 1.00 1.00 N +ATOM 680 C4 A A 21 -2.967 19.528 7.113 1.00 1.00 C +ATOM 681 H5' A A 21 -5.460 17.744 11.789 1.00 1.00 H +ATOM 682 H5'' A A 21 -6.652 16.630 11.087 1.00 1.00 H +ATOM 683 H4' A A 21 -7.247 18.870 10.444 1.00 1.00 H +ATOM 684 H3' A A 21 -6.258 17.037 8.322 1.00 1.00 H +ATOM 685 H2' A A 21 -5.797 18.673 6.744 1.00 1.00 H +ATOM 686 HO2' A A 21 -7.695 19.740 6.578 1.00 1.00 H +ATOM 687 H1' A A 21 -5.089 20.807 8.319 1.00 1.00 H +ATOM 688 H8 A A 21 -3.383 17.805 9.813 1.00 1.00 H +ATOM 689 H61 A A 21 0.973 18.478 5.460 1.00 1.00 H +ATOM 690 H62 A A 21 0.531 17.656 6.938 1.00 1.00 H +ATOM 691 H2 A A 21 -2.456 21.182 4.436 1.00 1.00 H +ATOM 692 P A A 22 -8.837 16.943 7.354 1.00 1.00 P +ATOM 693 OP1 A A 22 -10.129 16.470 7.898 1.00 1.00 O +ATOM 694 OP2 A A 22 -7.823 15.964 6.903 1.00 1.00 O +ATOM 695 O5' A A 22 -9.141 17.951 6.138 1.00 1.00 O +ATOM 696 C5' A A 22 -8.761 17.612 4.803 1.00 1.00 C +ATOM 697 C4' A A 22 -7.869 18.685 4.189 1.00 1.00 C +ATOM 698 O4' A A 22 -6.680 18.819 4.974 1.00 1.00 O +ATOM 699 C3' A A 22 -7.438 18.384 2.760 1.00 1.00 C +ATOM 700 O3' A A 22 -8.295 19.070 1.839 1.00 1.00 O +ATOM 701 C2' A A 22 -6.033 18.960 2.674 1.00 1.00 C +ATOM 702 O2' A A 22 -6.051 20.301 2.177 1.00 1.00 O +ATOM 703 C1' A A 22 -5.536 18.910 4.114 1.00 1.00 C +ATOM 704 N9 A A 22 -4.663 17.758 4.401 1.00 1.00 N +ATOM 705 C8 A A 22 -4.876 16.701 5.249 1.00 1.00 C +ATOM 706 N7 A A 22 -3.891 15.846 5.284 1.00 1.00 N +ATOM 707 C5 A A 22 -2.960 16.375 4.396 1.00 1.00 C +ATOM 708 C6 A A 22 -1.690 15.940 3.982 1.00 1.00 C +ATOM 709 N6 A A 22 -1.119 14.821 4.432 1.00 1.00 N +ATOM 710 N1 A A 22 -1.038 16.703 3.089 1.00 1.00 N +ATOM 711 C2 A A 22 -1.612 17.816 2.647 1.00 1.00 C +ATOM 712 N3 A A 22 -2.793 18.328 2.958 1.00 1.00 N +ATOM 713 C4 A A 22 -3.422 17.540 3.855 1.00 1.00 C +ATOM 714 H5' A A 22 -9.657 17.502 4.194 1.00 1.00 H +ATOM 715 H5'' A A 22 -8.222 16.664 4.816 1.00 1.00 H +ATOM 716 H4' A A 22 -8.399 19.635 4.204 1.00 1.00 H +ATOM 717 H3' A A 22 -7.434 17.310 2.575 1.00 1.00 H +ATOM 718 H2' A A 22 -5.408 18.322 2.044 1.00 1.00 H +ATOM 719 HO2' A A 22 -6.672 20.328 1.448 1.00 1.00 H +ATOM 720 H1' A A 22 -4.994 19.827 4.339 1.00 1.00 H +ATOM 721 H8 A A 22 -5.786 16.585 5.839 1.00 1.00 H +ATOM 722 H61 A A 22 -0.203 14.554 4.100 1.00 1.00 H +ATOM 723 H62 A A 22 -1.602 14.242 5.102 1.00 1.00 H +ATOM 724 H2 A A 22 -1.029 18.388 1.924 1.00 1.00 H +ATOM 725 P A A 23 -8.880 18.313 0.541 1.00 1.00 P +ATOM 726 OP1 A A 23 -9.656 19.291 -0.253 1.00 1.00 O +ATOM 727 OP2 A A 23 -9.519 17.057 0.990 1.00 1.00 O +ATOM 728 O5' A A 23 -7.550 17.931 -0.289 1.00 1.00 O +ATOM 729 C5' A A 23 -6.977 18.853 -1.224 1.00 1.00 C +ATOM 730 C4' A A 23 -5.604 18.383 -1.704 1.00 1.00 C +ATOM 731 O4' A A 23 -4.743 18.207 -0.580 1.00 1.00 O +ATOM 732 C3' A A 23 -5.626 17.060 -2.459 1.00 1.00 C +ATOM 733 O3' A A 23 -5.695 17.301 -3.868 1.00 1.00 O +ATOM 734 C2' A A 23 -4.288 16.427 -2.118 1.00 1.00 C +ATOM 735 O2' A A 23 -3.292 16.750 -3.096 1.00 1.00 O +ATOM 736 C1' A A 23 -3.947 17.029 -0.757 1.00 1.00 C +ATOM 737 N9 A A 23 -4.232 16.133 0.374 1.00 1.00 N +ATOM 738 C8 A A 23 -5.421 15.933 1.028 1.00 1.00 C +ATOM 739 N7 A A 23 -5.353 15.053 1.990 1.00 1.00 N +ATOM 740 C5 A A 23 -4.023 14.642 1.971 1.00 1.00 C +ATOM 741 C6 A A 23 -3.302 13.716 2.746 1.00 1.00 C +ATOM 742 N6 A A 23 -3.849 13.006 3.733 1.00 1.00 N +ATOM 743 N1 A A 23 -2.001 13.557 2.459 1.00 1.00 N +ATOM 744 C2 A A 23 -1.462 14.263 1.474 1.00 1.00 C +ATOM 745 N3 A A 23 -2.029 15.156 0.678 1.00 1.00 N +ATOM 746 C4 A A 23 -3.335 15.296 0.990 1.00 1.00 C +ATOM 747 H5' A A 23 -6.872 19.827 -0.746 1.00 1.00 H +ATOM 748 H5'' A A 23 -7.641 18.948 -2.083 1.00 1.00 H +ATOM 749 H4' A A 23 -5.176 19.148 -2.348 1.00 1.00 H +ATOM 750 H3' A A 23 -6.453 16.431 -2.122 1.00 1.00 H +ATOM 751 H2' A A 23 -4.402 15.344 -2.026 1.00 1.00 H +ATOM 752 HO2' A A 23 -3.564 17.563 -3.526 1.00 1.00 H +ATOM 753 H1' A A 23 -2.894 17.303 -0.737 1.00 1.00 H +ATOM 754 H8 A A 23 -6.339 16.461 0.768 1.00 1.00 H +ATOM 755 H61 A A 23 -3.283 12.354 4.259 1.00 1.00 H +ATOM 756 H62 A A 23 -4.834 13.117 3.961 1.00 1.00 H +ATOM 757 H2 A A 23 -0.402 14.083 1.295 1.00 1.00 H +ATOM 758 P C A 24 -6.504 16.294 -4.832 1.00 1.00 P +ATOM 759 OP1 C A 24 -6.408 16.803 -6.218 1.00 1.00 O +ATOM 760 OP2 C A 24 -7.832 16.044 -4.228 1.00 1.00 O +ATOM 761 O5' C A 24 -5.642 14.936 -4.733 1.00 1.00 O +ATOM 762 C5' C A 24 -4.251 14.927 -5.067 1.00 1.00 C +ATOM 763 C4' C A 24 -3.501 13.826 -4.319 1.00 1.00 C +ATOM 764 O4' C A 24 -3.742 13.950 -2.918 1.00 1.00 O +ATOM 765 C3' C A 24 -3.903 12.409 -4.705 1.00 1.00 C +ATOM 766 O3' C A 24 -3.049 11.925 -5.748 1.00 1.00 O +ATOM 767 C2' C A 24 -3.657 11.613 -3.435 1.00 1.00 C +ATOM 768 O2' C A 24 -2.340 11.053 -3.417 1.00 1.00 O +ATOM 769 C1' C A 24 -3.838 12.646 -2.329 1.00 1.00 C +ATOM 770 N1 C A 24 -5.142 12.556 -1.646 1.00 1.00 N +ATOM 771 C2 C A 24 -5.246 11.666 -0.590 1.00 1.00 C +ATOM 772 O2 C A 24 -4.276 10.988 -0.258 1.00 1.00 O +ATOM 773 N3 C A 24 -6.441 11.569 0.058 1.00 1.00 N +ATOM 774 C4 C A 24 -7.488 12.314 -0.318 1.00 1.00 C +ATOM 775 N4 C A 24 -8.645 12.196 0.337 1.00 1.00 N +ATOM 776 C5 C A 24 -7.384 13.234 -1.408 1.00 1.00 C +ATOM 777 C6 C A 24 -6.199 13.323 -2.042 1.00 1.00 C +ATOM 778 H5' C A 24 -3.817 15.892 -4.808 1.00 1.00 H +ATOM 779 H5'' C A 24 -4.144 14.766 -6.140 1.00 1.00 H +ATOM 780 H4' C A 24 -2.433 13.948 -4.493 1.00 1.00 H +ATOM 781 H3' C A 24 -4.954 12.366 -4.996 1.00 1.00 H +ATOM 782 H2' C A 24 -4.411 10.830 -3.335 1.00 1.00 H +ATOM 783 HO2' C A 24 -1.723 11.776 -3.274 1.00 1.00 H +ATOM 784 H1' C A 24 -3.042 12.527 -1.594 1.00 1.00 H +ATOM 785 H41 C A 24 -8.725 11.549 1.107 1.00 1.00 H +ATOM 786 H42 C A 24 -9.441 12.755 0.062 1.00 1.00 H +ATOM 787 H5 C A 24 -8.235 13.842 -1.717 1.00 1.00 H +ATOM 788 H6 C A 24 -6.083 14.014 -2.877 1.00 1.00 H +ATOM 789 P U A 25 -3.521 10.715 -6.704 1.00 1.00 P +ATOM 790 OP1 U A 25 -2.469 10.494 -7.721 1.00 1.00 O +ATOM 791 OP2 U A 25 -4.914 10.980 -7.130 1.00 1.00 O +ATOM 792 O5' U A 25 -3.534 9.450 -5.704 1.00 1.00 O +ATOM 793 C5' U A 25 -2.331 9.013 -5.062 1.00 1.00 C +ATOM 794 C4' U A 25 -2.610 7.949 -3.999 1.00 1.00 C +ATOM 795 O4' U A 25 -3.443 8.487 -2.973 1.00 1.00 O +ATOM 796 C3' U A 25 -3.320 6.709 -4.514 1.00 1.00 C +ATOM 797 O3' U A 25 -2.356 5.744 -4.953 1.00 1.00 O +ATOM 798 C2' U A 25 -4.049 6.188 -3.286 1.00 1.00 C +ATOM 799 O2' U A 25 -3.264 5.218 -2.584 1.00 1.00 O +ATOM 800 C1' U A 25 -4.273 7.441 -2.440 1.00 1.00 C +ATOM 801 N1 U A 25 -5.670 7.925 -2.458 1.00 1.00 N +ATOM 802 C2 U A 25 -6.504 7.529 -1.430 1.00 1.00 C +ATOM 803 O2 U A 25 -6.121 6.793 -0.523 1.00 1.00 O +ATOM 804 N3 U A 25 -7.801 8.007 -1.480 1.00 1.00 N +ATOM 805 C4 U A 25 -8.329 8.836 -2.455 1.00 1.00 C +ATOM 806 O4 U A 25 -9.501 9.202 -2.400 1.00 1.00 O +ATOM 807 C5 U A 25 -7.387 9.201 -3.490 1.00 1.00 C +ATOM 808 C6 U A 25 -6.111 8.744 -3.462 1.00 1.00 C +ATOM 809 H5' U A 25 -1.851 9.871 -4.590 1.00 1.00 H +ATOM 810 H5'' U A 25 -1.657 8.599 -5.813 1.00 1.00 H +ATOM 811 H4' U A 25 -1.665 7.651 -3.548 1.00 1.00 H +ATOM 812 H3' U A 25 -4.023 6.962 -5.308 1.00 1.00 H +ATOM 813 H2' U A 25 -5.009 5.770 -3.577 1.00 1.00 H +ATOM 814 HO2' U A 25 -3.799 4.889 -1.857 1.00 1.00 H +ATOM 815 H1' U A 25 -3.975 7.237 -1.412 1.00 1.00 H +ATOM 816 H3 U A 25 -8.422 7.725 -0.735 1.00 1.00 H +ATOM 817 H5 U A 25 -7.708 9.851 -4.303 1.00 1.00 H +ATOM 818 H6 U A 25 -5.423 9.034 -4.256 1.00 1.00 H +ATOM 819 P U A 26 -2.802 4.490 -5.865 1.00 1.00 P +ATOM 820 OP1 U A 26 -1.605 3.975 -6.566 1.00 1.00 O +ATOM 821 OP2 U A 26 -4.000 4.883 -6.641 1.00 1.00 O +ATOM 822 O5' U A 26 -3.251 3.400 -4.767 1.00 1.00 O +ATOM 823 C5' U A 26 -2.327 2.943 -3.776 1.00 1.00 C +ATOM 824 C4' U A 26 -3.041 2.209 -2.640 1.00 1.00 C +ATOM 825 O4' U A 26 -3.932 3.097 -1.962 1.00 1.00 O +ATOM 826 C3' U A 26 -3.887 1.032 -3.089 1.00 1.00 C +ATOM 827 O3' U A 26 -3.093 -0.159 -3.138 1.00 1.00 O +ATOM 828 C2' U A 26 -4.930 0.926 -1.991 1.00 1.00 C +ATOM 829 O2' U A 26 -4.504 0.065 -0.929 1.00 1.00 O +ATOM 830 C1' U A 26 -5.086 2.360 -1.514 1.00 1.00 C +ATOM 831 N1 U A 26 -6.289 3.021 -2.060 1.00 1.00 N +ATOM 832 C2 U A 26 -7.435 3.023 -1.288 1.00 1.00 C +ATOM 833 O2 U A 26 -7.483 2.481 -0.186 1.00 1.00 O +ATOM 834 N3 U A 26 -8.532 3.672 -1.830 1.00 1.00 N +ATOM 835 C4 U A 26 -8.579 4.308 -3.059 1.00 1.00 C +ATOM 836 O4 U A 26 -9.610 4.855 -3.442 1.00 1.00 O +ATOM 837 C5 U A 26 -7.337 4.255 -3.797 1.00 1.00 C +ATOM 838 C6 U A 26 -6.251 3.626 -3.287 1.00 1.00 C +ATOM 839 H5' U A 26 -1.793 3.801 -3.367 1.00 1.00 H +ATOM 840 H5'' U A 26 -1.609 2.267 -4.244 1.00 1.00 H +ATOM 841 H4' U A 26 -2.296 1.858 -1.928 1.00 1.00 H +ATOM 842 H3' U A 26 -4.357 1.237 -4.052 1.00 1.00 H +ATOM 843 H2' U A 26 -5.869 0.591 -2.412 1.00 1.00 H +ATOM 844 HO2' U A 26 -5.279 -0.144 -0.401 1.00 1.00 H +ATOM 845 H1' U A 26 -5.125 2.377 -0.425 1.00 1.00 H +ATOM 846 H3 U A 26 -9.377 3.682 -1.276 1.00 1.00 H +ATOM 847 H5 U A 26 -7.275 4.724 -4.779 1.00 1.00 H +ATOM 848 H6 U A 26 -5.326 3.603 -3.865 1.00 1.00 H +ATOM 849 P G A 27 -3.536 -1.406 -4.063 1.00 1.00 P +ATOM 850 OP1 G A 27 -2.503 -2.459 -3.946 1.00 1.00 O +ATOM 851 OP2 G A 27 -3.913 -0.885 -5.396 1.00 1.00 O +ATOM 852 O5' G A 27 -4.870 -1.928 -3.328 1.00 1.00 O +ATOM 853 C5' G A 27 -4.835 -2.249 -1.937 1.00 1.00 C +ATOM 854 C4' G A 27 -6.227 -2.241 -1.309 1.00 1.00 C +ATOM 855 O4' G A 27 -6.903 -1.026 -1.622 1.00 1.00 O +ATOM 856 C3' G A 27 -7.146 -3.360 -1.775 1.00 1.00 C +ATOM 857 O3' G A 27 -6.977 -4.506 -0.928 1.00 1.00 O +ATOM 858 C2' G A 27 -8.531 -2.775 -1.555 1.00 1.00 C +ATOM 859 O2' G A 27 -9.099 -3.224 -0.318 1.00 1.00 O +ATOM 860 C1' G A 27 -8.312 -1.269 -1.550 1.00 1.00 C +ATOM 861 N9 G A 27 -8.998 -0.568 -2.651 1.00 1.00 N +ATOM 862 C8 G A 27 -8.477 0.104 -3.727 1.00 1.00 C +ATOM 863 N7 G A 27 -9.378 0.665 -4.486 1.00 1.00 N +ATOM 864 C5 G A 27 -10.583 0.340 -3.870 1.00 1.00 C +ATOM 865 C6 G A 27 -11.916 0.672 -4.241 1.00 1.00 C +ATOM 866 O6 G A 27 -12.298 1.337 -5.200 1.00 1.00 O +ATOM 867 N1 G A 27 -12.839 0.141 -3.348 1.00 1.00 N +ATOM 868 C2 G A 27 -12.523 -0.614 -2.240 1.00 1.00 C +ATOM 869 N2 G A 27 -13.548 -1.040 -1.504 1.00 1.00 N +ATOM 870 N3 G A 27 -11.273 -0.924 -1.889 1.00 1.00 N +ATOM 871 C4 G A 27 -10.358 -0.417 -2.748 1.00 1.00 C +ATOM 872 H5' G A 27 -4.210 -1.518 -1.423 1.00 1.00 H +ATOM 873 H5'' G A 27 -4.395 -3.239 -1.812 1.00 1.00 H +ATOM 874 H4' G A 27 -6.122 -2.304 -0.228 1.00 1.00 H +ATOM 875 H3' G A 27 -6.980 -3.602 -2.824 1.00 1.00 H +ATOM 876 H2' G A 27 -9.179 -3.042 -2.394 1.00 1.00 H +ATOM 877 HO2' G A 27 -8.395 -3.227 0.333 1.00 1.00 H +ATOM 878 H1' G A 27 -8.681 -0.868 -0.607 1.00 1.00 H +ATOM 879 H8 G A 27 -7.408 0.162 -3.933 1.00 1.00 H +ATOM 880 H1 G A 27 -13.810 0.338 -3.545 1.00 1.00 H +ATOM 881 H21 G A 27 -14.498 -0.804 -1.768 1.00 1.00 H +ATOM 882 H22 G A 27 -13.380 -1.599 -0.678 1.00 1.00 H +ATOM 883 P G A 28 -7.613 -5.937 -1.323 1.00 1.00 P +ATOM 884 OP1 G A 28 -6.773 -6.997 -0.719 1.00 1.00 O +ATOM 885 OP2 G A 28 -7.870 -5.946 -2.780 1.00 1.00 O +ATOM 886 O5' G A 28 -9.038 -5.930 -0.563 1.00 1.00 O +ATOM 887 C5' G A 28 -9.133 -6.230 0.837 1.00 1.00 C +ATOM 888 C4' G A 28 -10.590 -6.396 1.283 1.00 1.00 C +ATOM 889 O4' G A 28 -11.269 -5.136 1.233 1.00 1.00 O +ATOM 890 C3' G A 28 -11.392 -7.373 0.431 1.00 1.00 C +ATOM 891 O3' G A 28 -11.387 -8.670 1.041 1.00 1.00 O +ATOM 892 C2' G A 28 -12.796 -6.792 0.443 1.00 1.00 C +ATOM 893 O2' G A 28 -13.575 -7.314 1.523 1.00 1.00 O +ATOM 894 C1' G A 28 -12.549 -5.301 0.603 1.00 1.00 C +ATOM 895 N9 G A 28 -12.502 -4.574 -0.674 1.00 1.00 N +ATOM 896 C8 G A 28 -11.398 -4.190 -1.389 1.00 1.00 C +ATOM 897 N7 G A 28 -11.676 -3.559 -2.494 1.00 1.00 N +ATOM 898 C5 G A 28 -13.066 -3.520 -2.519 1.00 1.00 C +ATOM 899 C6 G A 28 -13.945 -2.957 -3.486 1.00 1.00 C +ATOM 900 O6 G A 28 -13.659 -2.377 -4.531 1.00 1.00 O +ATOM 901 N1 G A 28 -15.274 -3.134 -3.130 1.00 1.00 N +ATOM 902 C2 G A 28 -15.709 -3.772 -1.987 1.00 1.00 C +ATOM 903 N2 G A 28 -17.029 -3.843 -1.822 1.00 1.00 N +ATOM 904 N3 G A 28 -14.886 -4.302 -1.076 1.00 1.00 N +ATOM 905 C4 G A 28 -13.583 -4.139 -1.407 1.00 1.00 C +ATOM 906 H5' G A 28 -8.677 -5.419 1.405 1.00 1.00 H +ATOM 907 H5'' G A 28 -8.591 -7.154 1.040 1.00 1.00 H +ATOM 908 H4' G A 28 -10.599 -6.745 2.314 1.00 1.00 H +ATOM 909 H3' G A 28 -10.998 -7.412 -0.587 1.00 1.00 H +ATOM 910 H2' G A 28 -13.284 -6.979 -0.513 1.00 1.00 H +ATOM 911 HO2' G A 28 -14.490 -7.067 1.360 1.00 1.00 H +ATOM 912 H1' G A 28 -13.324 -4.870 1.234 1.00 1.00 H +ATOM 913 H8 G A 28 -10.379 -4.389 -1.058 1.00 1.00 H +ATOM 914 H1 G A 28 -15.959 -2.760 -3.770 1.00 1.00 H +ATOM 915 H21 G A 28 -17.645 -3.442 -2.512 1.00 1.00 H +ATOM 916 H22 G A 28 -17.412 -4.298 -1.006 1.00 1.00 H +ATOM 917 P U A 29 -11.537 -10.005 0.148 1.00 1.00 P +ATOM 918 OP1 U A 29 -11.300 -11.175 1.024 1.00 1.00 O +ATOM 919 OP2 U A 29 -10.731 -9.832 -1.080 1.00 1.00 O +ATOM 920 O5' U A 29 -13.094 -9.999 -0.269 1.00 1.00 O +ATOM 921 C5' U A 29 -14.098 -10.425 0.656 1.00 1.00 C +ATOM 922 C4' U A 29 -15.497 -10.392 0.036 1.00 1.00 C +ATOM 923 O4' U A 29 -15.849 -9.052 -0.305 1.00 1.00 O +ATOM 924 C3' U A 29 -15.645 -11.207 -1.240 1.00 1.00 C +ATOM 925 O3' U A 29 -16.027 -12.552 -0.921 1.00 1.00 O +ATOM 926 C2' U A 29 -16.774 -10.498 -1.968 1.00 1.00 C +ATOM 927 O2' U A 29 -18.056 -11.030 -1.608 1.00 1.00 O +ATOM 928 C1' U A 29 -16.620 -9.051 -1.520 1.00 1.00 C +ATOM 929 N1 U A 29 -15.898 -8.209 -2.497 1.00 1.00 N +ATOM 930 C2 U A 29 -16.649 -7.503 -3.418 1.00 1.00 C +ATOM 931 O2 U A 29 -17.876 -7.573 -3.452 1.00 1.00 O +ATOM 932 N3 U A 29 -15.939 -6.710 -4.302 1.00 1.00 N +ATOM 933 C4 U A 29 -14.562 -6.566 -4.345 1.00 1.00 C +ATOM 934 O4 U A 29 -14.035 -5.831 -5.177 1.00 1.00 O +ATOM 935 C5 U A 29 -13.858 -7.340 -3.346 1.00 1.00 C +ATOM 936 C6 U A 29 -14.532 -8.124 -2.471 1.00 1.00 C +ATOM 937 H5' U A 29 -14.081 -9.768 1.525 1.00 1.00 H +ATOM 938 H5'' U A 29 -13.875 -11.443 0.977 1.00 1.00 H +ATOM 939 H4' U A 29 -16.213 -10.757 0.769 1.00 1.00 H +ATOM 940 H3' U A 29 -14.725 -11.181 -1.827 1.00 1.00 H +ATOM 941 H2' U A 29 -16.618 -10.561 -3.037 1.00 1.00 H +ATOM 942 HO2' U A 29 -18.107 -11.027 -0.650 1.00 1.00 H +ATOM 943 H1' U A 29 -17.603 -8.623 -1.327 1.00 1.00 H +ATOM 944 H3 U A 29 -16.475 -6.188 -4.980 1.00 1.00 H +ATOM 945 H5 U A 29 -12.770 -7.294 -3.299 1.00 1.00 H +ATOM 946 H6 U A 29 -13.976 -8.697 -1.728 1.00 1.00 H +ATOM 947 P U A 30 -15.676 -13.774 -1.917 1.00 1.00 P +ATOM 948 OP1 U A 30 -16.074 -15.035 -1.253 1.00 1.00 O +ATOM 949 OP2 U A 30 -14.287 -13.598 -2.391 1.00 1.00 O +ATOM 950 O5' U A 30 -16.667 -13.529 -3.166 1.00 1.00 O +ATOM 951 C5' U A 30 -18.051 -13.885 -3.079 1.00 1.00 C +ATOM 952 C4' U A 30 -18.811 -13.538 -4.360 1.00 1.00 C +ATOM 953 O4' U A 30 -18.801 -12.130 -4.569 1.00 1.00 O +ATOM 954 C3' U A 30 -18.240 -14.159 -5.625 1.00 1.00 C +ATOM 955 O3' U A 30 -18.812 -15.457 -5.830 1.00 1.00 O +ATOM 956 C2' U A 30 -18.713 -13.202 -6.706 1.00 1.00 C +ATOM 957 O2' U A 30 -20.019 -13.555 -7.177 1.00 1.00 O +ATOM 958 C1' U A 30 -18.723 -11.859 -5.978 1.00 1.00 C +ATOM 959 N1 U A 30 -17.507 -11.055 -6.198 1.00 1.00 N +ATOM 960 C2 U A 30 -17.558 -10.074 -7.168 1.00 1.00 C +ATOM 961 O2 U A 30 -18.564 -9.876 -7.847 1.00 1.00 O +ATOM 962 N3 U A 30 -16.407 -9.325 -7.335 1.00 1.00 N +ATOM 963 C4 U A 30 -15.227 -9.471 -6.624 1.00 1.00 C +ATOM 964 O4 U A 30 -14.262 -8.745 -6.856 1.00 1.00 O +ATOM 965 C5 U A 30 -15.265 -10.519 -5.631 1.00 1.00 C +ATOM 966 C6 U A 30 -16.381 -11.266 -5.449 1.00 1.00 C +ATOM 967 H5' U A 30 -18.502 -13.352 -2.243 1.00 1.00 H +ATOM 968 H5'' U A 30 -18.129 -14.958 -2.899 1.00 1.00 H +ATOM 969 H4' U A 30 -19.845 -13.858 -4.250 1.00 1.00 H +ATOM 970 H3' U A 30 -17.150 -14.200 -5.587 1.00 1.00 H +ATOM 971 H2' U A 30 -17.995 -13.178 -7.528 1.00 1.00 H +ATOM 972 HO2' U A 30 -20.438 -12.750 -7.491 1.00 1.00 H +ATOM 973 H1' U A 30 -19.598 -11.283 -6.283 1.00 1.00 H +ATOM 974 H3 U A 30 -16.429 -8.603 -8.041 1.00 1.00 H +ATOM 975 H5 U A 30 -14.383 -10.712 -5.019 1.00 1.00 H +ATOM 976 H6 U A 30 -16.382 -12.051 -4.691 1.00 1.00 H +ATOM 977 P C A 31 -18.000 -16.607 -6.615 1.00 1.00 P +ATOM 978 OP1 C A 31 -18.940 -17.708 -6.918 1.00 1.00 O +ATOM 979 OP2 C A 31 -16.753 -16.886 -5.870 1.00 1.00 O +ATOM 980 O5' C A 31 -17.607 -15.887 -8.000 1.00 1.00 O +ATOM 981 C5' C A 31 -18.560 -15.780 -9.058 1.00 1.00 C +ATOM 982 C4' C A 31 -17.984 -15.034 -10.259 1.00 1.00 C +ATOM 983 O4' C A 31 -17.707 -13.679 -9.918 1.00 1.00 O +ATOM 984 C3' C A 31 -16.677 -15.598 -10.776 1.00 1.00 C +ATOM 985 O3' C A 31 -16.931 -16.673 -11.686 1.00 1.00 O +ATOM 986 C2' C A 31 -16.076 -14.410 -11.511 1.00 1.00 C +ATOM 987 O2' C A 31 -16.492 -14.370 -12.880 1.00 1.00 O +ATOM 988 C1' C A 31 -16.611 -13.212 -10.723 1.00 1.00 C +ATOM 989 N1 C A 31 -15.618 -12.602 -9.814 1.00 1.00 N +ATOM 990 C2 C A 31 -14.919 -11.498 -10.275 1.00 1.00 C +ATOM 991 O2 C A 31 -15.118 -11.075 -11.412 1.00 1.00 O +ATOM 992 N3 C A 31 -14.018 -10.908 -9.442 1.00 1.00 N +ATOM 993 C4 C A 31 -13.813 -11.382 -8.206 1.00 1.00 C +ATOM 994 N4 C A 31 -12.923 -10.781 -7.415 1.00 1.00 N +ATOM 995 C5 C A 31 -14.532 -12.521 -7.725 1.00 1.00 C +ATOM 996 C6 C A 31 -15.421 -13.098 -8.557 1.00 1.00 C +ATOM 997 H5' C A 31 -19.437 -15.245 -8.694 1.00 1.00 H +ATOM 998 H5'' C A 31 -18.859 -16.782 -9.370 1.00 1.00 H +ATOM 999 H4' C A 31 -18.716 -15.042 -11.064 1.00 1.00 H +ATOM 1000 H3' C A 31 -16.033 -15.913 -9.952 1.00 1.00 H +ATOM 1001 H2' C A 31 -14.994 -14.442 -11.438 1.00 1.00 H +ATOM 1002 HO2' C A 31 -17.439 -14.519 -12.896 1.00 1.00 H +ATOM 1003 H1' C A 31 -16.977 -12.454 -11.417 1.00 1.00 H +ATOM 1004 H41 C A 31 -12.414 -9.978 -7.748 1.00 1.00 H +ATOM 1005 H42 C A 31 -12.760 -11.129 -6.482 1.00 1.00 H +ATOM 1006 H5 C A 31 -14.367 -12.909 -6.718 1.00 1.00 H +ATOM 1007 H6 C A 31 -15.989 -13.967 -8.223 1.00 1.00 H +ATOM 1008 P U A 32 -16.094 -18.048 -11.585 1.00 1.00 P +ATOM 1009 OP1 U A 32 -16.910 -19.128 -12.180 1.00 1.00 O +ATOM 1010 OP2 U A 32 -15.588 -18.180 -10.201 1.00 1.00 O +ATOM 1011 O5' U A 32 -14.841 -17.768 -12.558 1.00 1.00 O +ATOM 1012 C5' U A 32 -15.057 -17.235 -13.865 1.00 1.00 C +ATOM 1013 C4' U A 32 -14.041 -16.150 -14.218 1.00 1.00 C +ATOM 1014 O4' U A 32 -14.055 -15.115 -13.247 1.00 1.00 O +ATOM 1015 C3' U A 32 -12.600 -16.615 -14.290 1.00 1.00 C +ATOM 1016 O3' U A 32 -12.324 -17.103 -15.610 1.00 1.00 O +ATOM 1017 C2' U A 32 -11.817 -15.333 -14.052 1.00 1.00 C +ATOM 1018 O2' U A 32 -11.357 -14.759 -15.281 1.00 1.00 O +ATOM 1019 C1' U A 32 -12.808 -14.414 -13.338 1.00 1.00 C +ATOM 1020 N1 U A 32 -12.372 -13.980 -11.988 1.00 1.00 N +ATOM 1021 C2 U A 32 -11.744 -12.752 -11.905 1.00 1.00 C +ATOM 1022 O2 U A 32 -11.547 -12.051 -12.895 1.00 1.00 O +ATOM 1023 N3 U A 32 -11.345 -12.358 -10.641 1.00 1.00 N +ATOM 1024 C4 U A 32 -11.518 -13.077 -9.469 1.00 1.00 C +ATOM 1025 O4 U A 32 -11.125 -12.627 -8.395 1.00 1.00 O +ATOM 1026 C5 U A 32 -12.182 -14.348 -9.650 1.00 1.00 C +ATOM 1027 C6 U A 32 -12.582 -14.755 -10.879 1.00 1.00 C +ATOM 1028 H5' U A 32 -16.060 -16.808 -13.910 1.00 1.00 H +ATOM 1029 H5'' U A 32 -14.982 -18.040 -14.596 1.00 1.00 H +ATOM 1030 H4' U A 32 -14.315 -15.717 -15.178 1.00 1.00 H +ATOM 1031 H3' U A 32 -12.381 -17.363 -13.527 1.00 1.00 H +ATOM 1032 H2' U A 32 -10.985 -15.551 -13.386 1.00 1.00 H +ATOM 1033 HO2' U A 32 -11.624 -13.838 -15.283 1.00 1.00 H +ATOM 1034 H1' U A 32 -12.964 -13.530 -13.962 1.00 1.00 H +ATOM 1035 H3 U A 32 -10.885 -11.462 -10.565 1.00 1.00 H +ATOM 1036 H5 U A 32 -12.363 -14.987 -8.786 1.00 1.00 H +ATOM 1037 H6 U A 32 -13.080 -15.718 -10.987 1.00 1.00 H +ATOM 1038 P U A 33 -10.976 -17.924 -15.932 1.00 1.00 P +ATOM 1039 OP1 U A 33 -11.099 -18.485 -17.296 1.00 1.00 O +ATOM 1040 OP2 U A 33 -10.696 -18.823 -14.790 1.00 1.00 O +ATOM 1041 O5' U A 33 -9.839 -16.776 -15.961 1.00 1.00 O +ATOM 1042 C5' U A 33 -9.803 -15.797 -17.008 1.00 1.00 C +ATOM 1043 C4' U A 33 -8.455 -15.075 -17.067 1.00 1.00 C +ATOM 1044 O4' U A 33 -8.450 -13.959 -16.175 1.00 1.00 O +ATOM 1045 C3' U A 33 -7.274 -15.951 -16.686 1.00 1.00 C +ATOM 1046 O3' U A 33 -6.691 -16.507 -17.865 1.00 1.00 O +ATOM 1047 C2' U A 33 -6.286 -14.995 -16.034 1.00 1.00 C +ATOM 1048 O2' U A 33 -5.292 -14.560 -16.966 1.00 1.00 O +ATOM 1049 C1' U A 33 -7.154 -13.832 -15.562 1.00 1.00 C +ATOM 1050 N1 U A 33 -7.361 -13.801 -14.105 1.00 1.00 N +ATOM 1051 C2 U A 33 -6.296 -13.430 -13.306 1.00 1.00 C +ATOM 1052 O2 U A 33 -5.202 -13.122 -13.776 1.00 1.00 O +ATOM 1053 N3 U A 33 -6.531 -13.427 -11.943 1.00 1.00 N +ATOM 1054 C4 U A 33 -7.723 -13.756 -11.318 1.00 1.00 C +ATOM 1055 O4 U A 33 -7.820 -13.718 -10.094 1.00 1.00 O +ATOM 1056 C5 U A 33 -8.780 -14.130 -12.230 1.00 1.00 C +ATOM 1057 C6 U A 33 -8.573 -14.141 -13.570 1.00 1.00 C +ATOM 1058 H5' U A 33 -10.591 -15.063 -16.836 1.00 1.00 H +ATOM 1059 H5'' U A 33 -9.982 -16.291 -17.964 1.00 1.00 H +ATOM 1060 H4' U A 33 -8.301 -14.703 -18.078 1.00 1.00 H +ATOM 1061 H3' U A 33 -7.579 -16.734 -15.989 1.00 1.00 H +ATOM 1062 H2' U A 33 -5.820 -15.480 -15.173 1.00 1.00 H +ATOM 1063 HO2' U A 33 -5.644 -13.792 -17.422 1.00 1.00 H +ATOM 1064 H1' U A 33 -6.699 -12.894 -15.875 1.00 1.00 H +ATOM 1065 H3 U A 33 -5.762 -13.158 -11.346 1.00 1.00 H +ATOM 1066 H5 U A 33 -9.757 -14.407 -11.835 1.00 1.00 H +ATOM 1067 H6 U A 33 -9.389 -14.427 -14.234 1.00 1.00 H +ATOM 1068 P C A 34 -5.566 -17.649 -17.749 1.00 1.00 P +ATOM 1069 OP1 C A 34 -5.175 -18.050 -19.118 1.00 1.00 O +ATOM 1070 OP2 C A 34 -6.040 -18.668 -16.786 1.00 1.00 O +ATOM 1071 O5' C A 34 -4.335 -16.853 -17.082 1.00 1.00 O +ATOM 1072 C5' C A 34 -3.554 -17.456 -16.047 1.00 1.00 C +ATOM 1073 C4' C A 34 -2.629 -16.443 -15.374 1.00 1.00 C +ATOM 1074 O4' C A 34 -3.402 -15.475 -14.667 1.00 1.00 O +ATOM 1075 C3' C A 34 -1.666 -17.059 -14.373 1.00 1.00 C +ATOM 1076 O3' C A 34 -0.419 -17.338 -15.016 1.00 1.00 O +ATOM 1077 C2' C A 34 -1.471 -15.970 -13.328 1.00 1.00 C +ATOM 1078 O2' C A 34 -0.288 -15.206 -13.589 1.00 1.00 O +ATOM 1079 C1' C A 34 -2.728 -15.109 -13.453 1.00 1.00 C +ATOM 1080 N1 C A 34 -3.688 -15.293 -12.351 1.00 1.00 N +ATOM 1081 C2 C A 34 -3.466 -14.593 -11.176 1.00 1.00 C +ATOM 1082 O2 C A 34 -2.492 -13.850 -11.077 1.00 1.00 O +ATOM 1083 N3 C A 34 -4.348 -14.755 -10.152 1.00 1.00 N +ATOM 1084 C4 C A 34 -5.405 -15.568 -10.278 1.00 1.00 C +ATOM 1085 N4 C A 34 -6.250 -15.704 -9.256 1.00 1.00 N +ATOM 1086 C5 C A 34 -5.638 -16.293 -11.489 1.00 1.00 C +ATOM 1087 C6 C A 34 -4.758 -16.126 -12.496 1.00 1.00 C +ATOM 1088 H5' C A 34 -2.952 -18.257 -16.477 1.00 1.00 H +ATOM 1089 H5'' C A 34 -4.223 -17.880 -15.298 1.00 1.00 H +ATOM 1090 H4' C A 34 -2.056 -15.929 -16.142 1.00 1.00 H +ATOM 1091 H3' C A 34 -2.092 -17.958 -13.923 1.00 1.00 H +ATOM 1092 H2' C A 34 -1.428 -16.417 -12.331 1.00 1.00 H +ATOM 1093 HO2' C A 34 0.067 -14.928 -12.739 1.00 1.00 H +ATOM 1094 H1' C A 34 -2.442 -14.059 -13.504 1.00 1.00 H +ATOM 1095 H41 C A 34 -6.090 -15.193 -8.399 1.00 1.00 H +ATOM 1096 H42 C A 34 -7.051 -16.314 -9.340 1.00 1.00 H +ATOM 1097 H5 C A 34 -6.497 -16.955 -11.594 1.00 1.00 H +ATOM 1098 H6 C A 34 -4.904 -16.661 -13.434 1.00 1.00 H +ATOM 1099 P C A 35 0.436 -18.639 -14.611 1.00 1.00 P +ATOM 1100 OP1 C A 35 1.805 -18.477 -15.147 1.00 1.00 O +ATOM 1101 OP2 C A 35 -0.354 -19.843 -14.956 1.00 1.00 O +ATOM 1102 O5' C A 35 0.509 -18.521 -13.008 1.00 1.00 O +ATOM 1103 C5' C A 35 0.826 -19.661 -12.206 1.00 1.00 C +ATOM 1104 C4' C A 35 1.799 -19.296 -11.087 1.00 1.00 C +ATOM 1105 O4' C A 35 1.479 -18.002 -10.571 1.00 1.00 O +ATOM 1106 C3' C A 35 1.797 -20.266 -9.913 1.00 1.00 C +ATOM 1107 O3' C A 35 2.863 -21.208 -10.071 1.00 1.00 O +ATOM 1108 C2' C A 35 2.067 -19.376 -8.711 1.00 1.00 C +ATOM 1109 O2' C A 35 3.467 -19.282 -8.429 1.00 1.00 O +ATOM 1110 C1' C A 35 1.493 -18.034 -9.136 1.00 1.00 C +ATOM 1111 N1 C A 35 0.113 -17.803 -8.675 1.00 1.00 N +ATOM 1112 C2 C A 35 -0.069 -17.422 -7.355 1.00 1.00 C +ATOM 1113 O2 C A 35 0.901 -17.304 -6.610 1.00 1.00 O +ATOM 1114 N3 C A 35 -1.338 -17.187 -6.920 1.00 1.00 N +ATOM 1115 C4 C A 35 -2.384 -17.322 -7.747 1.00 1.00 C +ATOM 1116 N4 C A 35 -3.614 -17.084 -7.289 1.00 1.00 N +ATOM 1117 C5 C A 35 -2.200 -17.716 -9.110 1.00 1.00 C +ATOM 1118 C6 C A 35 -0.941 -17.946 -9.530 1.00 1.00 C +ATOM 1119 H5' C A 35 1.279 -20.427 -12.837 1.00 1.00 H +ATOM 1120 H5'' C A 35 -0.092 -20.056 -11.770 1.00 1.00 H +ATOM 1121 H4' C A 35 2.805 -19.257 -11.502 1.00 1.00 H +ATOM 1122 H3' C A 35 0.832 -20.768 -9.818 1.00 1.00 H +ATOM 1123 H2' C A 35 1.523 -19.745 -7.845 1.00 1.00 H +ATOM 1124 HO2' C A 35 3.921 -19.171 -9.267 1.00 1.00 H +ATOM 1125 H1' C A 35 2.133 -17.235 -8.764 1.00 1.00 H +ATOM 1126 H41 C A 35 -3.749 -16.805 -6.330 1.00 1.00 H +ATOM 1127 H42 C A 35 -4.409 -17.183 -7.903 1.00 1.00 H +ATOM 1128 H5 C A 35 -3.049 -17.829 -9.784 1.00 1.00 H +ATOM 1129 H6 C A 35 -0.763 -18.249 -10.561 1.00 1.00 H +ATOM 1130 P U A 36 2.775 -22.681 -9.425 1.00 1.00 P +ATOM 1131 OP1 U A 36 3.978 -23.438 -9.836 1.00 1.00 O +ATOM 1132 OP2 U A 36 1.428 -23.230 -9.699 1.00 1.00 O +ATOM 1133 O5' U A 36 2.884 -22.380 -7.848 1.00 1.00 O +ATOM 1134 C5' U A 36 3.988 -21.634 -7.331 1.00 1.00 C +ATOM 1135 C4' U A 36 3.770 -21.251 -5.870 1.00 1.00 C +ATOM 1136 O4' U A 36 2.504 -20.620 -5.715 1.00 1.00 O +ATOM 1137 C3' U A 36 3.776 -22.429 -4.911 1.00 1.00 C +ATOM 1138 O3' U A 36 5.107 -22.658 -4.435 1.00 1.00 O +ATOM 1139 C2' U A 36 2.889 -21.964 -3.764 1.00 1.00 C +ATOM 1140 O2' U A 36 3.669 -21.492 -2.662 1.00 1.00 O +ATOM 1141 C1' U A 36 2.052 -20.834 -4.373 1.00 1.00 C +ATOM 1142 N1 U A 36 0.603 -21.114 -4.415 1.00 1.00 N +ATOM 1143 C2 U A 36 -0.055 -21.190 -3.202 1.00 1.00 C +ATOM 1144 O2 U A 36 0.532 -21.058 -2.130 1.00 1.00 O +ATOM 1145 N3 U A 36 -1.416 -21.426 -3.264 1.00 1.00 N +ATOM 1146 C4 U A 36 -2.166 -21.589 -4.417 1.00 1.00 C +ATOM 1147 O4 U A 36 -3.377 -21.793 -4.353 1.00 1.00 O +ATOM 1148 C5 U A 36 -1.397 -21.495 -5.638 1.00 1.00 C +ATOM 1149 C6 U A 36 -0.062 -21.264 -5.601 1.00 1.00 C +ATOM 1150 H5' U A 36 4.114 -20.726 -7.921 1.00 1.00 H +ATOM 1151 H5'' U A 36 4.893 -22.237 -7.409 1.00 1.00 H +ATOM 1152 H4' U A 36 4.544 -20.548 -5.570 1.00 1.00 H +ATOM 1153 H3' U A 36 3.363 -23.321 -5.385 1.00 1.00 H +ATOM 1154 H2' U A 36 2.233 -22.780 -3.448 1.00 1.00 H +ATOM 1155 HO2' U A 36 3.195 -21.726 -1.860 1.00 1.00 H +ATOM 1156 H1' U A 36 2.215 -19.921 -3.798 1.00 1.00 H +ATOM 1157 H3 U A 36 -1.911 -21.483 -2.385 1.00 1.00 H +ATOM 1158 H5 U A 36 -1.897 -21.608 -6.599 1.00 1.00 H +ATOM 1159 H6 U A 36 0.494 -21.199 -6.537 1.00 1.00 H +ATOM 1160 P A A 37 5.557 -24.111 -3.900 1.00 1.00 P +ATOM 1161 OP1 A A 37 7.009 -24.067 -3.614 1.00 1.00 O +ATOM 1162 OP2 A A 37 5.019 -25.133 -4.824 1.00 1.00 O +ATOM 1163 O5' A A 37 4.775 -24.236 -2.497 1.00 1.00 O +ATOM 1164 C5' A A 37 5.080 -23.349 -1.419 1.00 1.00 C +ATOM 1165 C4' A A 37 4.227 -23.636 -0.186 1.00 1.00 C +ATOM 1166 O4' A A 37 2.853 -23.362 -0.488 1.00 1.00 O +ATOM 1167 C3' A A 37 4.315 -25.082 0.310 1.00 1.00 C +ATOM 1168 O3' A A 37 4.449 -25.091 1.735 1.00 1.00 O +ATOM 1169 C2' A A 37 2.977 -25.696 -0.071 1.00 1.00 C +ATOM 1170 O2' A A 37 2.534 -26.630 0.921 1.00 1.00 O +ATOM 1171 C1' A A 37 2.051 -24.496 -0.151 1.00 1.00 C +ATOM 1172 N9 A A 37 0.984 -24.623 -1.163 1.00 1.00 N +ATOM 1173 C8 A A 37 1.071 -25.067 -2.457 1.00 1.00 C +ATOM 1174 N7 A A 37 -0.070 -25.079 -3.089 1.00 1.00 N +ATOM 1175 C5 A A 37 -0.978 -24.610 -2.145 1.00 1.00 C +ATOM 1176 C6 A A 37 -2.364 -24.386 -2.191 1.00 1.00 C +ATOM 1177 N6 A A 37 -3.105 -24.617 -3.275 1.00 1.00 N +ATOM 1178 N1 A A 37 -2.949 -23.916 -1.077 1.00 1.00 N +ATOM 1179 C2 A A 37 -2.206 -23.688 0.000 1.00 1.00 C +ATOM 1180 N3 A A 37 -0.903 -23.858 0.167 1.00 1.00 N +ATOM 1181 C4 A A 37 -0.345 -24.330 -0.967 1.00 1.00 C +ATOM 1182 H5' A A 37 4.903 -22.324 -1.742 1.00 1.00 H +ATOM 1183 H5'' A A 37 6.131 -23.459 -1.155 1.00 1.00 H +ATOM 1184 H4' A A 37 4.539 -22.971 0.619 1.00 1.00 H +ATOM 1185 H3' A A 37 5.139 -25.611 -0.170 1.00 1.00 H +ATOM 1186 H2' A A 37 3.052 -26.177 -1.049 1.00 1.00 H +ATOM 1187 HO2' A A 37 2.283 -26.123 1.696 1.00 1.00 H +ATOM 1188 H1' A A 37 1.596 -24.331 0.825 1.00 1.00 H +ATOM 1189 H8 A A 37 2.009 -25.381 -2.916 1.00 1.00 H +ATOM 1190 H61 A A 37 -4.100 -24.439 -3.255 1.00 1.00 H +ATOM 1191 H62 A A 37 -2.674 -24.971 -4.117 1.00 1.00 H +ATOM 1192 H2 A A 37 -2.744 -23.309 0.868 1.00 1.00 H +ATOM 1193 P A A 38 5.085 -26.365 2.488 1.00 1.00 P +ATOM 1194 OP1 A A 38 6.557 -26.306 2.333 1.00 1.00 O +ATOM 1195 OP2 A A 38 4.346 -27.572 2.059 1.00 1.00 O +ATOM 1196 O5' A A 38 4.730 -26.078 4.031 1.00 1.00 O +ATOM 1197 C5' A A 38 5.758 -25.725 4.961 1.00 1.00 C +ATOM 1198 C4' A A 38 5.241 -24.757 6.022 1.00 1.00 C +ATOM 1199 O4' A A 38 4.888 -23.516 5.409 1.00 1.00 O +ATOM 1200 C3' A A 38 4.013 -25.258 6.774 1.00 1.00 C +ATOM 1201 O3' A A 38 4.423 -25.885 7.998 1.00 1.00 O +ATOM 1202 C2' A A 38 3.228 -23.989 7.071 1.00 1.00 C +ATOM 1203 O2' A A 38 3.558 -23.462 8.361 1.00 1.00 O +ATOM 1204 C1' A A 38 3.653 -23.037 5.958 1.00 1.00 C +ATOM 1205 N9 A A 38 2.683 -22.939 4.851 1.00 1.00 N +ATOM 1206 C8 A A 38 2.788 -23.417 3.571 1.00 1.00 C +ATOM 1207 N7 A A 38 1.750 -23.159 2.823 1.00 1.00 N +ATOM 1208 C5 A A 38 0.896 -22.458 3.671 1.00 1.00 C +ATOM 1209 C6 A A 38 -0.378 -21.898 3.484 1.00 1.00 C +ATOM 1210 N6 A A 38 -1.042 -21.960 2.328 1.00 1.00 N +ATOM 1211 N1 A A 38 -0.937 -21.274 4.534 1.00 1.00 N +ATOM 1212 C2 A A 38 -0.273 -21.216 5.682 1.00 1.00 C +ATOM 1213 N3 A A 38 0.923 -21.701 5.981 1.00 1.00 N +ATOM 1214 C4 A A 38 1.457 -22.320 4.908 1.00 1.00 C +ATOM 1215 H5' A A 38 6.580 -25.254 4.421 1.00 1.00 H +ATOM 1216 H5'' A A 38 6.122 -26.629 5.448 1.00 1.00 H +ATOM 1217 H4' A A 38 6.037 -24.570 6.741 1.00 1.00 H +ATOM 1218 H3' A A 38 3.429 -25.941 6.153 1.00 1.00 H +ATOM 1219 H2' A A 38 2.157 -24.188 6.998 1.00 1.00 H +ATOM 1220 HO2' A A 38 4.315 -23.954 8.685 1.00 1.00 H +ATOM 1221 H1' A A 38 3.811 -22.045 6.379 1.00 1.00 H +ATOM 1222 H8 A A 38 3.660 -23.963 3.209 1.00 1.00 H +ATOM 1223 H61 A A 38 -1.956 -21.539 2.247 1.00 1.00 H +ATOM 1224 H62 A A 38 -0.629 -22.427 1.533 1.00 1.00 H +ATOM 1225 H2 A A 38 -0.784 -20.695 6.492 1.00 1.00 H +ATOM 1226 P G A 39 3.548 -27.064 8.666 1.00 1.00 P +ATOM 1227 OP1 G A 39 4.336 -27.652 9.772 1.00 1.00 O +ATOM 1228 OP2 G A 39 3.040 -27.935 7.582 1.00 1.00 O +ATOM 1229 O5' G A 39 2.292 -26.280 9.307 1.00 1.00 O +ATOM 1230 C5' G A 39 2.467 -25.435 10.449 1.00 1.00 C +ATOM 1231 C4' G A 39 1.284 -24.484 10.641 1.00 1.00 C +ATOM 1232 O4' G A 39 1.026 -23.793 9.416 1.00 1.00 O +ATOM 1233 C3' G A 39 -0.019 -25.169 11.056 1.00 1.00 C +ATOM 1234 O3' G A 39 -0.192 -25.061 12.476 1.00 1.00 O +ATOM 1235 C2' G A 39 -1.089 -24.359 10.340 1.00 1.00 C +ATOM 1236 O2' G A 39 -1.544 -23.262 11.141 1.00 1.00 O +ATOM 1237 C1' G A 39 -0.367 -23.872 9.094 1.00 1.00 C +ATOM 1238 N9 G A 39 -0.501 -24.773 7.933 1.00 1.00 N +ATOM 1239 C8 G A 39 0.283 -25.842 7.586 1.00 1.00 C +ATOM 1240 N7 G A 39 -0.086 -26.432 6.483 1.00 1.00 N +ATOM 1241 C5 G A 39 -1.195 -25.702 6.068 1.00 1.00 C +ATOM 1242 C6 G A 39 -2.025 -25.875 4.925 1.00 1.00 C +ATOM 1243 O6 G A 39 -1.939 -26.724 4.041 1.00 1.00 O +ATOM 1244 N1 G A 39 -3.034 -24.922 4.880 1.00 1.00 N +ATOM 1245 C2 G A 39 -3.225 -23.927 5.815 1.00 1.00 C +ATOM 1246 N2 G A 39 -4.250 -23.104 5.598 1.00 1.00 N +ATOM 1247 N3 G A 39 -2.447 -23.763 6.890 1.00 1.00 N +ATOM 1248 C4 G A 39 -1.457 -24.683 6.950 1.00 1.00 C +ATOM 1249 H5' G A 39 3.376 -24.849 10.318 1.00 1.00 H +ATOM 1250 H5'' G A 39 2.573 -26.059 11.338 1.00 1.00 H +ATOM 1251 H4' G A 39 1.548 -23.748 11.398 1.00 1.00 H +ATOM 1252 H3' G A 39 -0.034 -26.211 10.729 1.00 1.00 H +ATOM 1253 H2' G A 39 -1.923 -25.002 10.057 1.00 1.00 H +ATOM 1254 HO2' G A 39 -2.367 -22.950 10.757 1.00 1.00 H +ATOM 1255 H1' G A 39 -0.735 -22.883 8.825 1.00 1.00 H +ATOM 1256 H8 G A 39 1.139 -26.169 8.176 1.00 1.00 H +ATOM 1257 H1 G A 39 -3.666 -24.981 4.094 1.00 1.00 H +ATOM 1258 H21 G A 39 -4.836 -23.232 4.785 1.00 1.00 H +ATOM 1259 H22 G A 39 -4.443 -22.354 6.247 1.00 1.00 H +ATOM 1260 P U A 40 -0.815 -26.281 13.330 1.00 1.00 P +ATOM 1261 OP1 U A 40 -0.722 -25.933 14.765 1.00 1.00 O +ATOM 1262 OP2 U A 40 -0.217 -27.542 12.837 1.00 1.00 O +ATOM 1263 O5' U A 40 -2.370 -26.268 12.911 1.00 1.00 O +ATOM 1264 C5' U A 40 -3.224 -25.198 13.322 1.00 1.00 C +ATOM 1265 C4' U A 40 -4.567 -25.238 12.596 1.00 1.00 C +ATOM 1266 O4' U A 40 -4.361 -25.031 11.198 1.00 1.00 O +ATOM 1267 C3' U A 40 -5.318 -26.553 12.741 1.00 1.00 C +ATOM 1268 O3' U A 40 -6.213 -26.474 13.860 1.00 1.00 O +ATOM 1269 C2' U A 40 -6.107 -26.641 11.445 1.00 1.00 C +ATOM 1270 O2' U A 40 -7.382 -26.003 11.569 1.00 1.00 O +ATOM 1271 C1' U A 40 -5.210 -25.912 10.447 1.00 1.00 C +ATOM 1272 N1 U A 40 -4.330 -26.805 9.662 1.00 1.00 N +ATOM 1273 C2 U A 40 -4.749 -27.167 8.397 1.00 1.00 C +ATOM 1274 O2 U A 40 -5.822 -26.789 7.930 1.00 1.00 O +ATOM 1275 N3 U A 40 -3.891 -27.983 7.683 1.00 1.00 N +ATOM 1276 C4 U A 40 -2.667 -28.462 8.118 1.00 1.00 C +ATOM 1277 O4 U A 40 -1.983 -29.183 7.395 1.00 1.00 O +ATOM 1278 C5 U A 40 -2.308 -28.033 9.452 1.00 1.00 C +ATOM 1279 C6 U A 40 -3.133 -27.233 10.170 1.00 1.00 C +ATOM 1280 H5' U A 40 -2.732 -24.249 13.109 1.00 1.00 H +ATOM 1281 H5'' U A 40 -3.398 -25.275 14.396 1.00 1.00 H +ATOM 1282 H4' U A 40 -5.193 -24.432 12.973 1.00 1.00 H +ATOM 1283 H3' U A 40 -4.626 -27.392 12.838 1.00 1.00 H +ATOM 1284 H2' U A 40 -6.222 -27.682 11.148 1.00 1.00 H +ATOM 1285 HO2' U A 40 -7.774 -26.307 12.391 1.00 1.00 H +ATOM 1286 H1' U A 40 -5.827 -25.324 9.766 1.00 1.00 H +ATOM 1287 H3 U A 40 -4.184 -28.255 6.755 1.00 1.00 H +ATOM 1288 H5 U A 40 -1.363 -28.357 9.885 1.00 1.00 H +ATOM 1289 H6 U A 40 -2.839 -26.926 11.174 1.00 1.00 H +ATOM 1290 P C A 41 -6.489 -27.756 14.800 1.00 1.00 P +ATOM 1291 OP1 C A 41 -7.318 -27.316 15.945 1.00 1.00 O +ATOM 1292 OP2 C A 41 -5.197 -28.436 15.046 1.00 1.00 O +ATOM 1293 O5' C A 41 -7.390 -28.711 13.866 1.00 1.00 O +ATOM 1294 C5' C A 41 -8.797 -28.485 13.736 1.00 1.00 C +ATOM 1295 C4' C A 41 -9.388 -29.280 12.573 1.00 1.00 C +ATOM 1296 O4' C A 41 -8.634 -29.029 11.393 1.00 1.00 O +ATOM 1297 C3' C A 41 -9.387 -30.790 12.772 1.00 1.00 C +ATOM 1298 O3' C A 41 -10.609 -31.211 13.390 1.00 1.00 O +ATOM 1299 C2' C A 41 -9.316 -31.328 11.353 1.00 1.00 C +ATOM 1300 O2' C A 41 -10.623 -31.589 10.830 1.00 1.00 O +ATOM 1301 C1' C A 41 -8.619 -30.209 10.579 1.00 1.00 C +ATOM 1302 N1 C A 41 -7.209 -30.504 10.248 1.00 1.00 N +ATOM 1303 C2 C A 41 -6.948 -31.068 9.010 1.00 1.00 C +ATOM 1304 O2 C A 41 -7.872 -31.310 8.236 1.00 1.00 O +ATOM 1305 N3 C A 41 -5.654 -31.342 8.684 1.00 1.00 N +ATOM 1306 C4 C A 41 -4.659 -31.074 9.539 1.00 1.00 C +ATOM 1307 N4 C A 41 -3.403 -31.355 9.191 1.00 1.00 N +ATOM 1308 C5 C A 41 -4.923 -30.491 10.818 1.00 1.00 C +ATOM 1309 C6 C A 41 -6.206 -30.223 11.130 1.00 1.00 C +ATOM 1310 H5' C A 41 -8.972 -27.422 13.564 1.00 1.00 H +ATOM 1311 H5'' C A 41 -9.294 -28.781 14.660 1.00 1.00 H +ATOM 1312 H4' C A 41 -10.411 -28.947 12.402 1.00 1.00 H +ATOM 1313 H3' C A 41 -8.517 -31.105 13.351 1.00 1.00 H +ATOM 1314 H2' C A 41 -8.702 -32.227 11.328 1.00 1.00 H +ATOM 1315 HO2' C A 41 -11.257 -31.207 11.441 1.00 1.00 H +ATOM 1316 H1' C A 41 -9.171 -30.013 9.659 1.00 1.00 H +ATOM 1317 H41 C A 41 -3.209 -31.765 8.290 1.00 1.00 H +ATOM 1318 H42 C A 41 -2.646 -31.155 9.829 1.00 1.00 H +ATOM 1319 H5 C A 41 -4.115 -30.272 11.517 1.00 1.00 H +ATOM 1320 H6 C A 41 -6.445 -29.779 12.097 1.00 1.00 H +ATOM 1321 P C A 42 -10.670 -32.575 14.253 1.00 1.00 P +ATOM 1322 OP1 C A 42 -12.003 -32.660 14.887 1.00 1.00 O +ATOM 1323 OP2 C A 42 -9.451 -32.643 15.091 1.00 1.00 O +ATOM 1324 O5' C A 42 -10.571 -33.733 13.130 1.00 1.00 O +ATOM 1325 C5' C A 42 -11.663 -33.976 12.234 1.00 1.00 C +ATOM 1326 C4' C A 42 -11.261 -34.892 11.075 1.00 1.00 C +ATOM 1327 O4' C A 42 -10.163 -34.333 10.367 1.00 1.00 O +ATOM 1328 C3' C A 42 -10.820 -36.286 11.488 1.00 1.00 C +ATOM 1329 O3' C A 42 -11.951 -37.161 11.563 1.00 1.00 O +ATOM 1330 C2' C A 42 -9.912 -36.716 10.347 1.00 1.00 C +ATOM 1331 O2' C A 42 -10.635 -37.464 9.362 1.00 1.00 O +ATOM 1332 C1' C A 42 -9.394 -35.394 9.779 1.00 1.00 C +ATOM 1333 N1 C A 42 -7.973 -35.132 10.088 1.00 1.00 N +ATOM 1334 C2 C A 42 -7.035 -35.453 9.120 1.00 1.00 C +ATOM 1335 O2 C A 42 -7.395 -35.954 8.057 1.00 1.00 O +ATOM 1336 N3 C A 42 -5.723 -35.204 9.383 1.00 1.00 N +ATOM 1337 C4 C A 42 -5.347 -34.661 10.550 1.00 1.00 C +ATOM 1338 N4 C A 42 -4.053 -34.428 10.775 1.00 1.00 N +ATOM 1339 C5 C A 42 -6.311 -34.328 11.552 1.00 1.00 C +ATOM 1340 C6 C A 42 -7.608 -34.579 11.281 1.00 1.00 C +ATOM 1341 H5' C A 42 -12.005 -33.023 11.829 1.00 1.00 H +ATOM 1342 H5'' C A 42 -12.479 -34.440 12.786 1.00 1.00 H +ATOM 1343 H4' C A 42 -12.101 -34.978 10.389 1.00 1.00 H +ATOM 1344 H3' C A 42 -10.273 -36.259 12.431 1.00 1.00 H +ATOM 1345 H2' C A 42 -9.079 -37.300 10.737 1.00 1.00 H +ATOM 1346 HO2' C A 42 -10.645 -36.943 8.557 1.00 1.00 H +ATOM 1347 H1' C A 42 -9.539 -35.385 8.698 1.00 1.00 H +ATOM 1348 H41 C A 42 -3.371 -34.661 10.072 1.00 1.00 H +ATOM 1349 H42 C A 42 -3.758 -34.020 11.650 1.00 1.00 H +ATOM 1350 H5 C A 42 -6.008 -33.887 12.502 1.00 1.00 H +ATOM 1351 H6 C A 42 -8.370 -34.341 12.022 1.00 1.00 H +ATOM 1352 P U A 43 -11.888 -38.500 12.457 1.00 1.00 P +ATOM 1353 OP1 U A 43 -13.168 -39.224 12.292 1.00 1.00 O +ATOM 1354 OP2 U A 43 -11.421 -38.130 13.812 1.00 1.00 O +ATOM 1355 O5' U A 43 -10.728 -39.361 11.737 1.00 1.00 O +ATOM 1356 C5' U A 43 -10.930 -39.898 10.426 1.00 1.00 C +ATOM 1357 C4' U A 43 -9.654 -40.513 9.848 1.00 1.00 C +ATOM 1358 O4' U A 43 -8.613 -39.547 9.826 1.00 1.00 O +ATOM 1359 C3' U A 43 -9.116 -41.703 10.633 1.00 1.00 C +ATOM 1360 O3' U A 43 -9.592 -42.939 10.089 1.00 1.00 O +ATOM 1361 C2' U A 43 -7.594 -41.588 10.490 1.00 1.00 C +ATOM 1362 O2' U A 43 -7.062 -42.675 9.723 1.00 1.00 O +ATOM 1363 C1' U A 43 -7.374 -40.250 9.786 1.00 1.00 C +ATOM 1364 N1 U A 43 -6.340 -39.401 10.426 1.00 1.00 N +ATOM 1365 C2 U A 43 -5.064 -39.448 9.899 1.00 1.00 C +ATOM 1366 O2 U A 43 -4.779 -40.156 8.935 1.00 1.00 O +ATOM 1367 N3 U A 43 -4.120 -38.651 10.521 1.00 1.00 N +ATOM 1368 C4 U A 43 -4.340 -37.824 11.609 1.00 1.00 C +ATOM 1369 O4 U A 43 -3.424 -37.153 12.081 1.00 1.00 O +ATOM 1370 C5 U A 43 -5.703 -37.839 12.094 1.00 1.00 C +ATOM 1371 C6 U A 43 -6.644 -38.612 11.500 1.00 1.00 C +ATOM 1372 H5' U A 43 -11.270 -39.100 9.765 1.00 1.00 H +ATOM 1373 H5'' U A 43 -11.700 -40.667 10.475 1.00 1.00 H +ATOM 1374 H4' U A 43 -9.851 -40.829 8.826 1.00 1.00 H +ATOM 1375 H3' U A 43 -9.399 -41.612 11.685 1.00 1.00 H +ATOM 1376 HO3' U A 43 -10.238 -43.292 10.705 1.00 1.00 H +ATOM 1377 H2' U A 43 -7.130 -41.557 11.480 1.00 1.00 H +ATOM 1378 HO2' U A 43 -7.321 -42.537 8.810 1.00 1.00 H +ATOM 1379 H1' U A 43 -7.100 -40.433 8.746 1.00 1.00 H +ATOM 1380 H3 U A 43 -3.183 -38.674 10.146 1.00 1.00 H +ATOM 1381 H5 U A 43 -5.976 -37.220 12.949 1.00 1.00 H +ATOM 1382 H6 U A 43 -7.663 -38.604 11.886 1.00 1.00 H +TER 1383 U A 43 +ATOM 1384 O5' G B 44 -3.953 36.025 15.422 1.00 1.00 O +ATOM 1385 C5' G B 44 -4.826 36.976 14.814 1.00 1.00 C +ATOM 1386 C4' G B 44 -4.045 38.148 14.220 1.00 1.00 C +ATOM 1387 O4' G B 44 -3.463 38.920 15.276 1.00 1.00 O +ATOM 1388 C3' G B 44 -2.916 37.727 13.285 1.00 1.00 C +ATOM 1389 O3' G B 44 -3.351 37.834 11.926 1.00 1.00 O +ATOM 1390 C2' G B 44 -1.827 38.750 13.551 1.00 1.00 C +ATOM 1391 O2' G B 44 -1.942 39.876 12.674 1.00 1.00 O +ATOM 1392 C1' G B 44 -2.076 39.144 14.997 1.00 1.00 C +ATOM 1393 N9 G B 44 -1.293 38.362 15.969 1.00 1.00 N +ATOM 1394 C8 G B 44 -1.737 37.495 16.934 1.00 1.00 C +ATOM 1395 N7 G B 44 -0.784 36.963 17.645 1.00 1.00 N +ATOM 1396 C5 G B 44 0.378 37.516 17.116 1.00 1.00 C +ATOM 1397 C6 G B 44 1.736 37.308 17.488 1.00 1.00 C +ATOM 1398 O6 G B 44 2.181 36.580 18.372 1.00 1.00 O +ATOM 1399 N1 G B 44 2.600 38.058 16.701 1.00 1.00 N +ATOM 1400 C2 G B 44 2.211 38.903 15.684 1.00 1.00 C +ATOM 1401 N2 G B 44 3.190 39.539 15.040 1.00 1.00 N +ATOM 1402 N3 G B 44 0.935 39.100 15.332 1.00 1.00 N +ATOM 1403 C4 G B 44 0.077 38.375 16.089 1.00 1.00 C +ATOM 1404 H5' G B 44 -5.528 37.346 15.567 1.00 1.00 H +ATOM 1405 H5'' G B 44 -5.388 36.491 14.020 1.00 1.00 H +ATOM 1406 H4' G B 44 -4.735 38.785 13.670 1.00 1.00 H +ATOM 1407 H3' G B 44 -2.571 36.718 13.516 1.00 1.00 H +ATOM 1408 H2' G B 44 -0.844 38.285 13.458 1.00 1.00 H +ATOM 1409 HO2' G B 44 -1.801 40.665 13.202 1.00 1.00 H +ATOM 1410 H1' G B 44 -1.849 40.202 15.126 1.00 1.00 H +ATOM 1411 H8 G B 44 -2.793 37.272 17.093 1.00 1.00 H +ATOM 1412 H1 G B 44 3.583 37.962 16.907 1.00 1.00 H +ATOM 1413 H21 G B 44 4.152 39.388 15.309 1.00 1.00 H +ATOM 1414 H22 G B 44 2.971 40.171 14.285 1.00 1.00 H +ATOM 1415 HO5' G B 44 -3.054 36.328 15.275 1.00 1.00 H +ATOM 1416 P G B 45 -2.806 36.814 10.805 1.00 1.00 P +ATOM 1417 OP1 G B 45 -3.425 37.176 9.510 1.00 1.00 O +ATOM 1418 OP2 G B 45 -2.942 35.436 11.327 1.00 1.00 O +ATOM 1419 O5' G B 45 -1.238 37.170 10.731 1.00 1.00 O +ATOM 1420 C5' G B 45 -0.796 38.472 10.339 1.00 1.00 C +ATOM 1421 C4' G B 45 0.716 38.612 10.500 1.00 1.00 C +ATOM 1422 O4' G B 45 1.074 38.506 11.875 1.00 1.00 O +ATOM 1423 C3' G B 45 1.520 37.555 9.760 1.00 1.00 C +ATOM 1424 O3' G B 45 1.817 38.021 8.436 1.00 1.00 O +ATOM 1425 C2' G B 45 2.793 37.438 10.585 1.00 1.00 C +ATOM 1426 O2' G B 45 3.830 38.282 10.071 1.00 1.00 O +ATOM 1427 C1' G B 45 2.356 37.871 11.985 1.00 1.00 C +ATOM 1428 N9 G B 45 2.212 36.754 12.936 1.00 1.00 N +ATOM 1429 C8 G B 45 1.078 36.076 13.302 1.00 1.00 C +ATOM 1430 N7 G B 45 1.287 35.131 14.176 1.00 1.00 N +ATOM 1431 C5 G B 45 2.658 35.184 14.407 1.00 1.00 C +ATOM 1432 C6 G B 45 3.469 34.393 15.267 1.00 1.00 C +ATOM 1433 O6 G B 45 3.126 33.472 16.006 1.00 1.00 O +ATOM 1434 N1 G B 45 4.803 34.775 15.202 1.00 1.00 N +ATOM 1435 C2 G B 45 5.298 35.789 14.410 1.00 1.00 C +ATOM 1436 N2 G B 45 6.609 36.009 14.483 1.00 1.00 N +ATOM 1437 N3 G B 45 4.538 36.534 13.603 1.00 1.00 N +ATOM 1438 C4 G B 45 3.233 36.176 13.652 1.00 1.00 C +ATOM 1439 H5' G B 45 -1.291 39.218 10.960 1.00 1.00 H +ATOM 1440 H5'' G B 45 -1.063 38.641 9.296 1.00 1.00 H +ATOM 1441 H4' G B 45 1.017 39.595 10.144 1.00 1.00 H +ATOM 1442 H3' G B 45 0.983 36.605 9.736 1.00 1.00 H +ATOM 1443 H2' G B 45 3.121 36.399 10.612 1.00 1.00 H +ATOM 1444 HO2' G B 45 3.589 39.188 10.275 1.00 1.00 H +ATOM 1445 H1' G B 45 3.077 38.583 12.383 1.00 1.00 H +ATOM 1446 H8 G B 45 0.093 36.305 12.898 1.00 1.00 H +ATOM 1447 H1 G B 45 5.443 34.255 15.787 1.00 1.00 H +ATOM 1448 H21 G B 45 7.183 35.442 15.095 1.00 1.00 H +ATOM 1449 H22 G B 45 7.032 36.738 13.928 1.00 1.00 H +ATOM 1450 P G B 46 2.055 36.988 7.218 1.00 1.00 P +ATOM 1451 OP1 G B 46 2.147 37.770 5.964 1.00 1.00 O +ATOM 1452 OP2 G B 46 1.064 35.896 7.333 1.00 1.00 O +ATOM 1453 O5' G B 46 3.512 36.378 7.535 1.00 1.00 O +ATOM 1454 C5' G B 46 4.683 37.195 7.440 1.00 1.00 C +ATOM 1455 C4' G B 46 5.930 36.442 7.903 1.00 1.00 C +ATOM 1456 O4' G B 46 5.826 36.144 9.290 1.00 1.00 O +ATOM 1457 C3' G B 46 6.166 35.117 7.198 1.00 1.00 C +ATOM 1458 O3' G B 46 6.967 35.324 6.027 1.00 1.00 O +ATOM 1459 C2' G B 46 6.942 34.308 8.228 1.00 1.00 C +ATOM 1460 O2' G B 46 8.355 34.432 8.033 1.00 1.00 O +ATOM 1461 C1' G B 46 6.510 34.913 9.563 1.00 1.00 C +ATOM 1462 N9 G B 46 5.588 34.061 10.333 1.00 1.00 N +ATOM 1463 C8 G B 46 4.223 33.964 10.231 1.00 1.00 C +ATOM 1464 N7 G B 46 3.688 33.125 11.074 1.00 1.00 N +ATOM 1465 C5 G B 46 4.774 32.629 11.788 1.00 1.00 C +ATOM 1466 C6 G B 46 4.812 31.677 12.844 1.00 1.00 C +ATOM 1467 O6 G B 46 3.875 31.076 13.366 1.00 1.00 O +ATOM 1468 N1 G B 46 6.111 31.457 13.285 1.00 1.00 N +ATOM 1469 C2 G B 46 7.234 32.074 12.775 1.00 1.00 C +ATOM 1470 N2 G B 46 8.396 31.732 13.328 1.00 1.00 N +ATOM 1471 N3 G B 46 7.200 32.968 11.783 1.00 1.00 N +ATOM 1472 C4 G B 46 5.942 33.195 11.341 1.00 1.00 C +ATOM 1473 H5' G B 46 4.550 38.080 8.063 1.00 1.00 H +ATOM 1474 H5'' G B 46 4.818 37.507 6.403 1.00 1.00 H +ATOM 1475 H4' G B 46 6.799 37.079 7.754 1.00 1.00 H +ATOM 1476 H3' G B 46 5.219 34.630 6.954 1.00 1.00 H +ATOM 1477 H2' G B 46 6.639 33.263 8.186 1.00 1.00 H +ATOM 1478 HO2' G B 46 8.489 34.912 7.214 1.00 1.00 H +ATOM 1479 H1' G B 46 7.393 35.119 10.168 1.00 1.00 H +ATOM 1480 H8 G B 46 3.639 34.536 9.509 1.00 1.00 H +ATOM 1481 H1 G B 46 6.219 30.791 14.036 1.00 1.00 H +ATOM 1482 H21 G B 46 8.420 31.052 14.078 1.00 1.00 H +ATOM 1483 H22 G B 46 9.256 32.148 12.997 1.00 1.00 H +ATOM 1484 P A B 47 6.856 34.331 4.760 1.00 1.00 P +ATOM 1485 OP1 A B 47 7.764 34.831 3.705 1.00 1.00 O +ATOM 1486 OP2 A B 47 5.423 34.123 4.459 1.00 1.00 O +ATOM 1487 O5' A B 47 7.456 32.945 5.323 1.00 1.00 O +ATOM 1488 C5' A B 47 8.869 32.724 5.376 1.00 1.00 C +ATOM 1489 C4' A B 47 9.199 31.306 5.844 1.00 1.00 C +ATOM 1490 O4' A B 47 8.807 31.138 7.196 1.00 1.00 O +ATOM 1491 C3' A B 47 8.496 30.208 5.068 1.00 1.00 C +ATOM 1492 O3' A B 47 9.277 29.835 3.928 1.00 1.00 O +ATOM 1493 C2' A B 47 8.440 29.058 6.064 1.00 1.00 C +ATOM 1494 O2' A B 47 9.561 28.177 5.914 1.00 1.00 O +ATOM 1495 C1' A B 47 8.463 29.763 7.424 1.00 1.00 C +ATOM 1496 N9 A B 47 7.164 29.760 8.115 1.00 1.00 N +ATOM 1497 C8 A B 47 6.087 30.583 7.911 1.00 1.00 C +ATOM 1498 N7 A B 47 5.073 30.330 8.694 1.00 1.00 N +ATOM 1499 C5 A B 47 5.513 29.264 9.473 1.00 1.00 C +ATOM 1500 C6 A B 47 4.904 28.526 10.501 1.00 1.00 C +ATOM 1501 N6 A B 47 3.666 28.766 10.936 1.00 1.00 N +ATOM 1502 N1 A B 47 5.620 27.535 11.056 1.00 1.00 N +ATOM 1503 C2 A B 47 6.852 27.301 10.618 1.00 1.00 C +ATOM 1504 N3 A B 47 7.531 27.922 9.665 1.00 1.00 N +ATOM 1505 C4 A B 47 6.786 28.910 9.126 1.00 1.00 C +ATOM 1506 H5' A B 47 9.313 33.439 6.068 1.00 1.00 H +ATOM 1507 H5'' A B 47 9.293 32.880 4.383 1.00 1.00 H +ATOM 1508 H4' A B 47 10.274 31.155 5.777 1.00 1.00 H +ATOM 1509 H3' A B 47 7.490 30.518 4.779 1.00 1.00 H +ATOM 1510 H2' A B 47 7.502 28.510 5.949 1.00 1.00 H +ATOM 1511 HO2' A B 47 10.334 28.723 5.752 1.00 1.00 H +ATOM 1512 H1' A B 47 9.212 29.299 8.064 1.00 1.00 H +ATOM 1513 H8 A B 47 6.075 31.375 7.161 1.00 1.00 H +ATOM 1514 H61 A B 47 3.273 28.204 11.680 1.00 1.00 H +ATOM 1515 H62 A B 47 3.121 29.508 10.523 1.00 1.00 H +ATOM 1516 H2 A B 47 7.377 26.484 11.113 1.00 1.00 H +ATOM 1517 P U B 48 8.568 29.202 2.628 1.00 1.00 P +ATOM 1518 OP1 U B 48 9.628 28.776 1.687 1.00 1.00 O +ATOM 1519 OP2 U B 48 7.513 30.135 2.175 1.00 1.00 O +ATOM 1520 O5' U B 48 7.856 27.882 3.214 1.00 1.00 O +ATOM 1521 C5' U B 48 8.610 26.691 3.447 1.00 1.00 C +ATOM 1522 C4' U B 48 7.796 25.650 4.213 1.00 1.00 C +ATOM 1523 O4' U B 48 7.283 26.223 5.406 1.00 1.00 O +ATOM 1524 C3' U B 48 6.597 25.105 3.458 1.00 1.00 C +ATOM 1525 O3' U B 48 6.994 23.949 2.713 1.00 1.00 O +ATOM 1526 C2' U B 48 5.636 24.695 4.570 1.00 1.00 C +ATOM 1527 O2' U B 48 5.744 23.297 4.862 1.00 1.00 O +ATOM 1528 C1' U B 48 6.071 25.549 5.768 1.00 1.00 C +ATOM 1529 N1 U B 48 5.086 26.580 6.172 1.00 1.00 N +ATOM 1530 C2 U B 48 4.257 26.280 7.235 1.00 1.00 C +ATOM 1531 O2 U B 48 4.314 25.203 7.824 1.00 1.00 O +ATOM 1532 N3 U B 48 3.358 27.265 7.599 1.00 1.00 N +ATOM 1533 C4 U B 48 3.218 28.507 7.002 1.00 1.00 C +ATOM 1534 O4 U B 48 2.381 29.308 7.412 1.00 1.00 O +ATOM 1535 C5 U B 48 4.124 28.733 5.899 1.00 1.00 C +ATOM 1536 C6 U B 48 5.015 27.783 5.523 1.00 1.00 C +ATOM 1537 H5' U B 48 9.500 26.941 4.023 1.00 1.00 H +ATOM 1538 H5'' U B 48 8.913 26.269 2.488 1.00 1.00 H +ATOM 1539 H4' U B 48 8.449 24.823 4.483 1.00 1.00 H +ATOM 1540 H3' U B 48 6.155 25.868 2.815 1.00 1.00 H +ATOM 1541 H2' U B 48 4.612 24.951 4.287 1.00 1.00 H +ATOM 1542 HO2' U B 48 6.566 22.987 4.475 1.00 1.00 H +ATOM 1543 H1' U B 48 6.273 24.892 6.617 1.00 1.00 H +ATOM 1544 H3 U B 48 2.746 27.059 8.376 1.00 1.00 H +ATOM 1545 H5 U B 48 4.092 29.682 5.364 1.00 1.00 H +ATOM 1546 H6 U B 48 5.686 27.981 4.688 1.00 1.00 H +ATOM 1547 P A B 49 6.684 23.825 1.138 1.00 1.00 P +ATOM 1548 OP1 A B 49 7.229 25.021 0.457 1.00 1.00 O +ATOM 1549 OP2 A B 49 5.259 23.465 0.969 1.00 1.00 O +ATOM 1550 O5' A B 49 7.578 22.554 0.719 1.00 1.00 O +ATOM 1551 C5' A B 49 8.900 22.405 1.245 1.00 1.00 C +ATOM 1552 C4' A B 49 9.004 21.199 2.176 1.00 1.00 C +ATOM 1553 O4' A B 49 7.856 21.161 3.031 1.00 1.00 O +ATOM 1554 C3' A B 49 9.093 19.860 1.446 1.00 1.00 C +ATOM 1555 O3' A B 49 10.148 19.083 2.024 1.00 1.00 O +ATOM 1556 C2' A B 49 7.753 19.182 1.703 1.00 1.00 C +ATOM 1557 O2' A B 49 7.915 17.777 1.928 1.00 1.00 O +ATOM 1558 C1' A B 49 7.226 19.880 2.949 1.00 1.00 C +ATOM 1559 N9 A B 49 5.766 20.098 2.944 1.00 1.00 N +ATOM 1560 C8 A B 49 5.021 20.910 2.128 1.00 1.00 C +ATOM 1561 N7 A B 49 3.742 20.888 2.386 1.00 1.00 N +ATOM 1562 C5 A B 49 3.634 19.996 3.450 1.00 1.00 C +ATOM 1563 C6 A B 49 2.536 19.533 4.193 1.00 1.00 C +ATOM 1564 N6 A B 49 1.282 19.925 3.965 1.00 1.00 N +ATOM 1565 N1 A B 49 2.785 18.653 5.177 1.00 1.00 N +ATOM 1566 C2 A B 49 4.036 18.267 5.400 1.00 1.00 C +ATOM 1567 N3 A B 49 5.145 18.628 4.775 1.00 1.00 N +ATOM 1568 C4 A B 49 4.863 19.511 3.795 1.00 1.00 C +ATOM 1569 H5' A B 49 9.168 23.306 1.798 1.00 1.00 H +ATOM 1570 H5'' A B 49 9.597 22.275 0.418 1.00 1.00 H +ATOM 1571 H4' A B 49 9.890 21.316 2.799 1.00 1.00 H +ATOM 1572 H3' A B 49 9.253 20.008 0.377 1.00 1.00 H +ATOM 1573 H2' A B 49 7.079 19.363 0.864 1.00 1.00 H +ATOM 1574 HO2' A B 49 8.309 17.405 1.135 1.00 1.00 H +ATOM 1575 H1' A B 49 7.494 19.294 3.826 1.00 1.00 H +ATOM 1576 H8 A B 49 5.457 21.517 1.334 1.00 1.00 H +ATOM 1577 H61 A B 49 0.527 19.560 4.531 1.00 1.00 H +ATOM 1578 H62 A B 49 1.083 20.587 3.229 1.00 1.00 H +ATOM 1579 H2 A B 49 4.167 17.550 6.211 1.00 1.00 H +ATOM 1580 P U B 50 10.661 17.730 1.319 1.00 1.00 P +ATOM 1581 OP1 U B 50 12.015 17.979 0.776 1.00 1.00 O +ATOM 1582 OP2 U B 50 9.589 17.233 0.428 1.00 1.00 O +ATOM 1583 O5' U B 50 10.797 16.716 2.564 1.00 1.00 O +ATOM 1584 C5' U B 50 9.743 15.805 2.884 1.00 1.00 C +ATOM 1585 C4' U B 50 9.496 15.735 4.391 1.00 1.00 C +ATOM 1586 O4' U B 50 9.633 17.039 4.951 1.00 1.00 O +ATOM 1587 C3' U B 50 8.107 15.214 4.771 1.00 1.00 C +ATOM 1588 O3' U B 50 8.229 13.999 5.513 1.00 1.00 O +ATOM 1589 C2' U B 50 7.513 16.287 5.673 1.00 1.00 C +ATOM 1590 O2' U B 50 6.943 15.718 6.856 1.00 1.00 O +ATOM 1591 C1' U B 50 8.689 17.188 6.008 1.00 1.00 C +ATOM 1592 N1 U B 50 8.335 18.624 6.120 1.00 1.00 N +ATOM 1593 C2 U B 50 9.311 19.545 5.793 1.00 1.00 C +ATOM 1594 O2 U B 50 10.427 19.205 5.408 1.00 1.00 O +ATOM 1595 N3 U B 50 8.960 20.876 5.929 1.00 1.00 N +ATOM 1596 C4 U B 50 7.734 21.358 6.356 1.00 1.00 C +ATOM 1597 O4 U B 50 7.530 22.567 6.437 1.00 1.00 O +ATOM 1598 C5 U B 50 6.775 20.323 6.676 1.00 1.00 C +ATOM 1599 C6 U B 50 7.096 19.014 6.552 1.00 1.00 C +ATOM 1600 H5' U B 50 10.008 14.812 2.521 1.00 1.00 H +ATOM 1601 H5'' U B 50 8.830 16.132 2.388 1.00 1.00 H +ATOM 1602 H4' U B 50 10.248 15.089 4.839 1.00 1.00 H +ATOM 1603 H3' U B 50 7.487 15.071 3.884 1.00 1.00 H +ATOM 1604 H2' U B 50 6.767 16.855 5.123 1.00 1.00 H +ATOM 1605 HO2' U B 50 7.132 16.317 7.580 1.00 1.00 H +ATOM 1606 H1' U B 50 9.140 16.855 6.943 1.00 1.00 H +ATOM 1607 H3 U B 50 9.663 21.560 5.693 1.00 1.00 H +ATOM 1608 H5 U B 50 5.779 20.602 7.022 1.00 1.00 H +ATOM 1609 H6 U B 50 6.353 18.255 6.801 1.00 1.00 H +ATOM 1610 P G B 51 6.967 13.009 5.641 1.00 1.00 P +ATOM 1611 OP1 G B 51 6.809 12.642 7.067 1.00 1.00 O +ATOM 1612 OP2 G B 51 7.104 11.949 4.618 1.00 1.00 O +ATOM 1613 O5' G B 51 5.732 13.959 5.225 1.00 1.00 O +ATOM 1614 C5' G B 51 4.818 14.452 6.212 1.00 1.00 C +ATOM 1615 C4' G B 51 3.376 14.419 5.703 1.00 1.00 C +ATOM 1616 O4' G B 51 3.016 15.684 5.145 1.00 1.00 O +ATOM 1617 C3' G B 51 3.145 13.377 4.626 1.00 1.00 C +ATOM 1618 O3' G B 51 2.647 12.175 5.216 1.00 1.00 O +ATOM 1619 C2' G B 51 2.085 13.988 3.728 1.00 1.00 C +ATOM 1620 O2' G B 51 0.779 13.501 4.056 1.00 1.00 O +ATOM 1621 C1' G B 51 2.206 15.487 3.972 1.00 1.00 C +ATOM 1622 N9 G B 51 2.865 16.202 2.866 1.00 1.00 N +ATOM 1623 C8 G B 51 4.199 16.484 2.729 1.00 1.00 C +ATOM 1624 N7 G B 51 4.494 17.125 1.634 1.00 1.00 N +ATOM 1625 C5 G B 51 3.269 17.281 0.996 1.00 1.00 C +ATOM 1626 C6 G B 51 2.962 17.908 -0.245 1.00 1.00 C +ATOM 1627 O6 G B 51 3.727 18.455 -1.033 1.00 1.00 O +ATOM 1628 N1 G B 51 1.603 17.847 -0.522 1.00 1.00 N +ATOM 1629 C2 G B 51 0.655 17.259 0.288 1.00 1.00 C +ATOM 1630 N2 G B 51 -0.603 17.300 -0.151 1.00 1.00 N +ATOM 1631 N3 G B 51 0.941 16.669 1.454 1.00 1.00 N +ATOM 1632 C4 G B 51 2.264 16.719 1.742 1.00 1.00 C +ATOM 1633 H5' G B 51 5.084 15.478 6.464 1.00 1.00 H +ATOM 1634 H5'' G B 51 4.894 13.833 7.108 1.00 1.00 H +ATOM 1635 H4' G B 51 2.712 14.211 6.541 1.00 1.00 H +ATOM 1636 H3' G B 51 4.063 13.189 4.066 1.00 1.00 H +ATOM 1637 H2' G B 51 2.325 13.775 2.689 1.00 1.00 H +ATOM 1638 HO2' G B 51 0.591 13.772 4.958 1.00 1.00 H +ATOM 1639 H1' G B 51 1.217 15.912 4.136 1.00 1.00 H +ATOM 1640 H8 G B 51 4.946 16.200 3.471 1.00 1.00 H +ATOM 1641 H1 G B 51 1.307 18.272 -1.389 1.00 1.00 H +ATOM 1642 H21 G B 51 -0.815 17.744 -1.026 1.00 1.00 H +ATOM 1643 H22 G B 51 -1.341 16.891 0.396 1.00 1.00 H +ATOM 1644 P G B 52 2.669 10.803 4.379 1.00 1.00 P +ATOM 1645 OP1 G B 52 1.966 9.766 5.166 1.00 1.00 O +ATOM 1646 OP2 G B 52 4.055 10.566 3.914 1.00 1.00 O +ATOM 1647 O5' G B 52 1.767 11.166 3.098 1.00 1.00 O +ATOM 1648 C5' G B 52 2.314 11.060 1.782 1.00 1.00 C +ATOM 1649 C4' G B 52 1.227 11.122 0.714 1.00 1.00 C +ATOM 1650 O4' G B 52 0.893 12.490 0.435 1.00 1.00 O +ATOM 1651 C3' G B 52 1.636 10.479 -0.605 1.00 1.00 C +ATOM 1652 O3' G B 52 1.168 9.127 -0.651 1.00 1.00 O +ATOM 1653 C2' G B 52 0.910 11.312 -1.644 1.00 1.00 C +ATOM 1654 O2' G B 52 -0.388 10.778 -1.927 1.00 1.00 O +ATOM 1655 C1' G B 52 0.817 12.679 -0.984 1.00 1.00 C +ATOM 1656 N9 G B 52 1.899 13.602 -1.380 1.00 1.00 N +ATOM 1657 C8 G B 52 2.850 14.207 -0.598 1.00 1.00 C +ATOM 1658 N7 G B 52 3.668 14.976 -1.261 1.00 1.00 N +ATOM 1659 C5 G B 52 3.229 14.877 -2.578 1.00 1.00 C +ATOM 1660 C6 G B 52 3.731 15.495 -3.756 1.00 1.00 C +ATOM 1661 O6 G B 52 4.682 16.267 -3.868 1.00 1.00 O +ATOM 1662 N1 G B 52 2.998 15.127 -4.877 1.00 1.00 N +ATOM 1663 C2 G B 52 1.916 14.272 -4.869 1.00 1.00 C +ATOM 1664 N2 G B 52 1.339 14.039 -6.048 1.00 1.00 N +ATOM 1665 N3 G B 52 1.443 13.690 -3.763 1.00 1.00 N +ATOM 1666 C4 G B 52 2.145 14.038 -2.660 1.00 1.00 C +ATOM 1667 H5' G B 52 2.844 10.112 1.694 1.00 1.00 H +ATOM 1668 H5'' G B 52 3.016 11.876 1.620 1.00 1.00 H +ATOM 1669 H4' G B 52 0.337 10.619 1.088 1.00 1.00 H +ATOM 1670 H3' G B 52 2.718 10.533 -0.748 1.00 1.00 H +ATOM 1671 H2' G B 52 1.507 11.381 -2.552 1.00 1.00 H +ATOM 1672 HO2' G B 52 -0.260 9.928 -2.355 1.00 1.00 H +ATOM 1673 H1' G B 52 -0.142 13.131 -1.232 1.00 1.00 H +ATOM 1674 H8 G B 52 2.917 14.059 0.480 1.00 1.00 H +ATOM 1675 H1 G B 52 3.295 15.529 -5.754 1.00 1.00 H +ATOM 1676 H21 G B 52 1.700 14.483 -6.883 1.00 1.00 H +ATOM 1677 H22 G B 52 0.543 13.422 -6.108 1.00 1.00 H +ATOM 1678 P A B 53 2.192 7.908 -0.911 1.00 1.00 P +ATOM 1679 OP1 A B 53 1.473 6.641 -0.656 1.00 1.00 O +ATOM 1680 OP2 A B 53 3.449 8.199 -0.186 1.00 1.00 O +ATOM 1681 O5' A B 53 2.488 8.006 -2.494 1.00 1.00 O +ATOM 1682 C5' A B 53 1.626 7.347 -3.427 1.00 1.00 C +ATOM 1683 C4' A B 53 1.836 7.845 -4.859 1.00 1.00 C +ATOM 1684 O4' A B 53 1.757 9.265 -4.898 1.00 1.00 O +ATOM 1685 C3' A B 53 3.180 7.482 -5.476 1.00 1.00 C +ATOM 1686 O3' A B 53 3.090 6.216 -6.141 1.00 1.00 O +ATOM 1687 C2' A B 53 3.399 8.578 -6.506 1.00 1.00 C +ATOM 1688 O2' A B 53 2.974 8.165 -7.808 1.00 1.00 O +ATOM 1689 C1' A B 53 2.554 9.740 -5.990 1.00 1.00 C +ATOM 1690 N9 A B 53 3.356 10.877 -5.515 1.00 1.00 N +ATOM 1691 C8 A B 53 3.742 11.195 -4.237 1.00 1.00 C +ATOM 1692 N7 A B 53 4.456 12.284 -4.157 1.00 1.00 N +ATOM 1693 C5 A B 53 4.551 12.717 -5.477 1.00 1.00 C +ATOM 1694 C6 A B 53 5.183 13.823 -6.070 1.00 1.00 C +ATOM 1695 N6 A B 53 5.868 14.732 -5.376 1.00 1.00 N +ATOM 1696 N1 A B 53 5.079 13.950 -7.404 1.00 1.00 N +ATOM 1697 C2 A B 53 4.396 13.042 -8.090 1.00 1.00 C +ATOM 1698 N3 A B 53 3.761 11.966 -7.650 1.00 1.00 N +ATOM 1699 C4 A B 53 3.884 11.866 -6.310 1.00 1.00 C +ATOM 1700 H5' A B 53 0.591 7.532 -3.137 1.00 1.00 H +ATOM 1701 H5'' A B 53 1.816 6.275 -3.392 1.00 1.00 H +ATOM 1702 H4' A B 53 1.044 7.443 -5.487 1.00 1.00 H +ATOM 1703 H3' A B 53 3.972 7.486 -4.726 1.00 1.00 H +ATOM 1704 H2' A B 53 4.451 8.869 -6.517 1.00 1.00 H +ATOM 1705 HO2' A B 53 2.022 8.281 -7.850 1.00 1.00 H +ATOM 1706 H1' A B 53 1.896 10.083 -6.788 1.00 1.00 H +ATOM 1707 H8 A B 53 3.475 10.594 -3.368 1.00 1.00 H +ATOM 1708 H61 A B 53 6.303 15.508 -5.859 1.00 1.00 H +ATOM 1709 H62 A B 53 5.953 14.647 -4.374 1.00 1.00 H +ATOM 1710 H2 A B 53 4.351 13.205 -9.166 1.00 1.00 H +ATOM 1711 P A B 54 4.416 5.469 -6.675 1.00 1.00 P +ATOM 1712 OP1 A B 54 4.052 4.080 -7.030 1.00 1.00 O +ATOM 1713 OP2 A B 54 5.511 5.720 -5.709 1.00 1.00 O +ATOM 1714 O5' A B 54 4.759 6.263 -8.036 1.00 1.00 O +ATOM 1715 C5' A B 54 3.871 6.201 -9.155 1.00 1.00 C +ATOM 1716 C4' A B 54 4.364 7.059 -10.322 1.00 1.00 C +ATOM 1717 O4' A B 54 4.444 8.425 -9.916 1.00 1.00 O +ATOM 1718 C3' A B 54 5.743 6.686 -10.849 1.00 1.00 C +ATOM 1719 O3' A B 54 5.618 5.699 -11.881 1.00 1.00 O +ATOM 1720 C2' A B 54 6.235 7.998 -11.434 1.00 1.00 C +ATOM 1721 O2' A B 54 5.797 8.171 -12.786 1.00 1.00 O +ATOM 1722 C1' A B 54 5.601 9.030 -10.510 1.00 1.00 C +ATOM 1723 N9 A B 54 6.486 9.471 -9.416 1.00 1.00 N +ATOM 1724 C8 A B 54 6.647 8.933 -8.165 1.00 1.00 C +ATOM 1725 N7 A B 54 7.520 9.563 -7.428 1.00 1.00 N +ATOM 1726 C5 A B 54 7.968 10.593 -8.251 1.00 1.00 C +ATOM 1727 C6 A B 54 8.906 11.619 -8.059 1.00 1.00 C +ATOM 1728 N6 A B 54 9.592 11.778 -6.926 1.00 1.00 N +ATOM 1729 N1 A B 54 9.108 12.469 -9.080 1.00 1.00 N +ATOM 1730 C2 A B 54 8.424 12.302 -10.205 1.00 1.00 C +ATOM 1731 N3 A B 54 7.522 11.380 -10.507 1.00 1.00 N +ATOM 1732 C4 A B 54 7.342 10.545 -9.462 1.00 1.00 C +ATOM 1733 H5' A B 54 2.887 6.554 -8.849 1.00 1.00 H +ATOM 1734 H5'' A B 54 3.789 5.165 -9.487 1.00 1.00 H +ATOM 1735 H4' A B 54 3.647 6.988 -11.137 1.00 1.00 H +ATOM 1736 H3' A B 54 6.396 6.348 -10.041 1.00 1.00 H +ATOM 1737 H2' A B 54 7.321 8.059 -11.367 1.00 1.00 H +ATOM 1738 HO2' A B 54 6.181 8.991 -13.108 1.00 1.00 H +ATOM 1739 H1' A B 54 5.296 9.898 -11.093 1.00 1.00 H +ATOM 1740 H8 A B 54 6.098 8.057 -7.819 1.00 1.00 H +ATOM 1741 H61 A B 54 10.255 12.534 -6.840 1.00 1.00 H +ATOM 1742 H62 A B 54 9.447 11.144 -6.153 1.00 1.00 H +ATOM 1743 H2 A B 54 8.637 13.025 -10.993 1.00 1.00 H +ATOM 1744 P G B 55 6.570 4.396 -11.901 1.00 1.00 P +ATOM 1745 OP1 G B 55 6.126 3.520 -13.008 1.00 1.00 O +ATOM 1746 OP2 G B 55 6.651 3.860 -10.525 1.00 1.00 O +ATOM 1747 O5' G B 55 8.012 5.002 -12.290 1.00 1.00 O +ATOM 1748 C5' G B 55 8.346 5.264 -13.656 1.00 1.00 C +ATOM 1749 C4' G B 55 9.727 5.904 -13.789 1.00 1.00 C +ATOM 1750 O4' G B 55 9.719 7.205 -13.214 1.00 1.00 O +ATOM 1751 C3' G B 55 10.849 5.146 -13.101 1.00 1.00 C +ATOM 1752 O3' G B 55 11.416 4.181 -13.994 1.00 1.00 O +ATOM 1753 C2' G B 55 11.870 6.232 -12.805 1.00 1.00 C +ATOM 1754 O2' G B 55 12.841 6.330 -13.851 1.00 1.00 O +ATOM 1755 C1' G B 55 11.030 7.496 -12.707 1.00 1.00 C +ATOM 1756 N9 G B 55 10.883 7.983 -11.329 1.00 1.00 N +ATOM 1757 C8 G B 55 9.914 7.684 -10.406 1.00 1.00 C +ATOM 1758 N7 G B 55 10.059 8.304 -9.269 1.00 1.00 N +ATOM 1759 C5 G B 55 11.207 9.069 -9.448 1.00 1.00 C +ATOM 1760 C6 G B 55 11.861 9.957 -8.549 1.00 1.00 C +ATOM 1761 O6 G B 55 11.544 10.246 -7.397 1.00 1.00 O +ATOM 1762 N1 G B 55 12.988 10.526 -9.124 1.00 1.00 N +ATOM 1763 C2 G B 55 13.435 10.275 -10.404 1.00 1.00 C +ATOM 1764 N2 G B 55 14.542 10.914 -10.776 1.00 1.00 N +ATOM 1765 N3 G B 55 12.822 9.443 -11.252 1.00 1.00 N +ATOM 1766 C4 G B 55 11.720 8.878 -10.708 1.00 1.00 C +ATOM 1767 H5' G B 55 7.600 5.939 -14.077 1.00 1.00 H +ATOM 1768 H5'' G B 55 8.332 4.327 -14.213 1.00 1.00 H +ATOM 1769 H4' G B 55 9.966 6.001 -14.846 1.00 1.00 H +ATOM 1770 H3' G B 55 10.499 4.679 -12.178 1.00 1.00 H +ATOM 1771 H2' G B 55 12.349 6.044 -11.845 1.00 1.00 H +ATOM 1772 HO2' G B 55 13.479 5.627 -13.714 1.00 1.00 H +ATOM 1773 H1' G B 55 11.485 8.277 -13.313 1.00 1.00 H +ATOM 1774 H8 G B 55 9.099 6.988 -10.604 1.00 1.00 H +ATOM 1775 H1 G B 55 13.506 11.169 -8.544 1.00 1.00 H +ATOM 1776 H21 G B 55 15.003 11.541 -10.134 1.00 1.00 H +ATOM 1777 H22 G B 55 14.920 10.774 -11.702 1.00 1.00 H +ATOM 1778 P A B 56 12.296 2.956 -13.424 1.00 1.00 P +ATOM 1779 OP1 A B 56 12.324 1.895 -14.456 1.00 1.00 O +ATOM 1780 OP2 A B 56 11.822 2.642 -12.058 1.00 1.00 O +ATOM 1781 O5' A B 56 13.776 3.590 -13.311 1.00 1.00 O +ATOM 1782 C5' A B 56 14.516 3.933 -14.487 1.00 1.00 C +ATOM 1783 C4' A B 56 15.632 4.940 -14.192 1.00 1.00 C +ATOM 1784 O4' A B 56 15.096 6.079 -13.518 1.00 1.00 O +ATOM 1785 C3' A B 56 16.755 4.413 -13.310 1.00 1.00 C +ATOM 1786 O3' A B 56 17.762 3.795 -14.120 1.00 1.00 O +ATOM 1787 C2' A B 56 17.300 5.683 -12.675 1.00 1.00 C +ATOM 1788 O2' A B 56 18.303 6.290 -13.496 1.00 1.00 O +ATOM 1789 C1' A B 56 16.057 6.565 -12.570 1.00 1.00 C +ATOM 1790 N9 A B 56 15.421 6.541 -11.246 1.00 1.00 N +ATOM 1791 C8 A B 56 14.563 5.615 -10.710 1.00 1.00 C +ATOM 1792 N7 A B 56 14.165 5.903 -9.502 1.00 1.00 N +ATOM 1793 C5 A B 56 14.805 7.104 -9.217 1.00 1.00 C +ATOM 1794 C6 A B 56 14.800 7.938 -8.086 1.00 1.00 C +ATOM 1795 N6 A B 56 14.098 7.669 -6.984 1.00 1.00 N +ATOM 1796 N1 A B 56 15.548 9.053 -8.139 1.00 1.00 N +ATOM 1797 C2 A B 56 16.246 9.314 -9.238 1.00 1.00 C +ATOM 1798 N3 A B 56 16.332 8.613 -10.359 1.00 1.00 N +ATOM 1799 C4 A B 56 15.572 7.501 -10.275 1.00 1.00 C +ATOM 1800 H5' A B 56 13.834 4.365 -15.220 1.00 1.00 H +ATOM 1801 H5'' A B 56 14.957 3.027 -14.906 1.00 1.00 H +ATOM 1802 H4' A B 56 16.058 5.276 -15.136 1.00 1.00 H +ATOM 1803 H3' A B 56 16.370 3.729 -12.552 1.00 1.00 H +ATOM 1804 H2' A B 56 17.691 5.466 -11.678 1.00 1.00 H +ATOM 1805 HO2' A B 56 18.533 7.131 -13.091 1.00 1.00 H +ATOM 1806 H1' A B 56 16.319 7.597 -12.813 1.00 1.00 H +ATOM 1807 H8 A B 56 14.242 4.721 -11.246 1.00 1.00 H +ATOM 1808 H61 A B 56 14.134 8.312 -6.196 1.00 1.00 H +ATOM 1809 H62 A B 56 13.532 6.834 -6.933 1.00 1.00 H +ATOM 1810 H2 A B 56 16.830 10.234 -9.214 1.00 1.00 H +ATOM 1811 P A B 57 18.395 2.369 -13.705 1.00 1.00 P +ATOM 1812 OP1 A B 57 19.301 1.935 -14.792 1.00 1.00 O +ATOM 1813 OP2 A B 57 17.292 1.484 -13.268 1.00 1.00 O +ATOM 1814 O5' A B 57 19.290 2.729 -12.415 1.00 1.00 O +ATOM 1815 C5' A B 57 20.603 3.272 -12.569 1.00 1.00 C +ATOM 1816 C4' A B 57 21.177 3.754 -11.237 1.00 1.00 C +ATOM 1817 O4' A B 57 20.391 4.830 -10.729 1.00 1.00 O +ATOM 1818 C3' A B 57 21.209 2.701 -10.140 1.00 1.00 C +ATOM 1819 O3' A B 57 22.435 1.959 -10.211 1.00 1.00 O +ATOM 1820 C2' A B 57 21.181 3.543 -8.875 1.00 1.00 C +ATOM 1821 O2' A B 57 22.501 3.914 -8.467 1.00 1.00 O +ATOM 1822 C1' A B 57 20.361 4.761 -9.294 1.00 1.00 C +ATOM 1823 N9 A B 57 18.946 4.698 -8.888 1.00 1.00 N +ATOM 1824 C8 A B 57 17.895 4.086 -9.523 1.00 1.00 C +ATOM 1825 N7 A B 57 16.751 4.235 -8.913 1.00 1.00 N +ATOM 1826 C5 A B 57 17.067 5.001 -7.795 1.00 1.00 C +ATOM 1827 C6 A B 57 16.289 5.504 -6.739 1.00 1.00 C +ATOM 1828 N6 A B 57 14.974 5.300 -6.638 1.00 1.00 N +ATOM 1829 N1 A B 57 16.921 6.223 -5.796 1.00 1.00 N +ATOM 1830 C2 A B 57 18.229 6.423 -5.902 1.00 1.00 C +ATOM 1831 N3 A B 57 19.066 6.006 -6.841 1.00 1.00 N +ATOM 1832 C4 A B 57 18.402 5.287 -7.771 1.00 1.00 C +ATOM 1833 H5' A B 57 20.559 4.112 -13.262 1.00 1.00 H +ATOM 1834 H5'' A B 57 21.258 2.505 -12.984 1.00 1.00 H +ATOM 1835 H4' A B 57 22.187 4.120 -11.403 1.00 1.00 H +ATOM 1836 H3' A B 57 20.338 2.046 -10.196 1.00 1.00 H +ATOM 1837 H2' A B 57 20.666 3.007 -8.080 1.00 1.00 H +ATOM 1838 HO2' A B 57 22.470 4.837 -8.207 1.00 1.00 H +ATOM 1839 H1' A B 57 20.812 5.662 -8.879 1.00 1.00 H +ATOM 1840 H8 A B 57 18.006 3.524 -10.451 1.00 1.00 H +ATOM 1841 H61 A B 57 14.465 5.686 -5.856 1.00 1.00 H +ATOM 1842 H62 A B 57 14.491 4.761 -7.341 1.00 1.00 H +ATOM 1843 H2 A B 57 18.679 7.013 -5.102 1.00 1.00 H +ATOM 1844 P C B 58 22.480 0.391 -9.832 1.00 1.00 P +ATOM 1845 OP1 C B 58 23.866 -0.088 -10.024 1.00 1.00 O +ATOM 1846 OP2 C B 58 21.364 -0.285 -10.529 1.00 1.00 O +ATOM 1847 O5' C B 58 22.160 0.386 -8.251 1.00 1.00 O +ATOM 1848 C5' C B 58 23.179 0.698 -7.296 1.00 1.00 C +ATOM 1849 C4' C B 58 22.616 0.787 -5.878 1.00 1.00 C +ATOM 1850 O4' C B 58 21.698 1.864 -5.785 1.00 1.00 O +ATOM 1851 C3' C B 58 21.853 -0.440 -5.418 1.00 1.00 C +ATOM 1852 O3' C B 58 22.760 -1.393 -4.851 1.00 1.00 O +ATOM 1853 C2' C B 58 20.931 0.118 -4.339 1.00 1.00 C +ATOM 1854 O2' C B 58 21.501 -0.023 -3.034 1.00 1.00 O +ATOM 1855 C1' C B 58 20.769 1.591 -4.724 1.00 1.00 C +ATOM 1856 N1 C B 58 19.417 1.931 -5.218 1.00 1.00 N +ATOM 1857 C2 C B 58 18.537 2.527 -4.327 1.00 1.00 C +ATOM 1858 O2 C B 58 18.893 2.762 -3.175 1.00 1.00 O +ATOM 1859 N3 C B 58 17.287 2.838 -4.767 1.00 1.00 N +ATOM 1860 C4 C B 58 16.916 2.577 -6.029 1.00 1.00 C +ATOM 1861 N4 C B 58 15.683 2.892 -6.428 1.00 1.00 N +ATOM 1862 C5 C B 58 17.822 1.965 -6.950 1.00 1.00 C +ATOM 1863 C6 C B 58 19.056 1.661 -6.505 1.00 1.00 C +ATOM 1864 H5' C B 58 23.629 1.656 -7.559 1.00 1.00 H +ATOM 1865 H5'' C B 58 23.947 -0.075 -7.326 1.00 1.00 H +ATOM 1866 H4' C B 58 23.433 0.974 -5.186 1.00 1.00 H +ATOM 1867 H3' C B 58 21.276 -0.872 -6.237 1.00 1.00 H +ATOM 1868 H2' C B 58 19.964 -0.377 -4.391 1.00 1.00 H +ATOM 1869 HO2' C B 58 20.778 -0.199 -2.426 1.00 1.00 H +ATOM 1870 H1' C B 58 21.010 2.215 -3.866 1.00 1.00 H +ATOM 1871 H41 C B 58 15.039 3.325 -5.783 1.00 1.00 H +ATOM 1872 H42 C B 58 15.396 2.700 -7.377 1.00 1.00 H +ATOM 1873 H5 C B 58 17.526 1.756 -7.979 1.00 1.00 H +ATOM 1874 H6 C B 58 19.774 1.195 -7.181 1.00 1.00 H +ATOM 1875 P C B 59 22.360 -2.950 -4.746 1.00 1.00 P +ATOM 1876 OP1 C B 59 23.536 -3.695 -4.244 1.00 1.00 O +ATOM 1877 OP2 C B 59 21.720 -3.354 -6.018 1.00 1.00 O +ATOM 1878 O5' C B 59 21.236 -2.946 -3.590 1.00 1.00 O +ATOM 1879 C5' C B 59 21.580 -2.542 -2.262 1.00 1.00 C +ATOM 1880 C4' C B 59 20.356 -2.121 -1.452 1.00 1.00 C +ATOM 1881 O4' C B 59 19.611 -1.149 -2.170 1.00 1.00 O +ATOM 1882 C3' C B 59 19.383 -3.241 -1.128 1.00 1.00 C +ATOM 1883 O3' C B 59 19.741 -3.840 0.122 1.00 1.00 O +ATOM 1884 C2' C B 59 18.053 -2.524 -0.978 1.00 1.00 C +ATOM 1885 O2' C B 59 17.747 -2.273 0.398 1.00 1.00 O +ATOM 1886 C1' C B 59 18.242 -1.220 -1.754 1.00 1.00 C +ATOM 1887 N1 C B 59 17.384 -1.098 -2.952 1.00 1.00 N +ATOM 1888 C2 C B 59 16.200 -0.391 -2.809 1.00 1.00 C +ATOM 1889 O2 C B 59 15.895 0.088 -1.719 1.00 1.00 O +ATOM 1890 N3 C B 59 15.396 -0.251 -3.900 1.00 1.00 N +ATOM 1891 C4 C B 59 15.738 -0.784 -5.080 1.00 1.00 C +ATOM 1892 N4 C B 59 14.928 -0.628 -6.125 1.00 1.00 N +ATOM 1893 C5 C B 59 16.958 -1.514 -5.232 1.00 1.00 C +ATOM 1894 C6 C B 59 17.748 -1.647 -4.147 1.00 1.00 C +ATOM 1895 H5' C B 59 22.271 -1.702 -2.318 1.00 1.00 H +ATOM 1896 H5'' C B 59 22.071 -3.371 -1.754 1.00 1.00 H +ATOM 1897 H4' C B 59 20.692 -1.669 -0.521 1.00 1.00 H +ATOM 1898 H3' C B 59 19.347 -3.978 -1.931 1.00 1.00 H +ATOM 1899 H2' C B 59 17.264 -3.119 -1.445 1.00 1.00 H +ATOM 1900 HO2' C B 59 17.732 -1.321 0.518 1.00 1.00 H +ATOM 1901 H1' C B 59 18.039 -0.384 -1.082 1.00 1.00 H +ATOM 1902 H41 C B 59 14.067 -0.111 -6.023 1.00 1.00 H +ATOM 1903 H42 C B 59 15.177 -1.024 -7.020 1.00 1.00 H +ATOM 1904 H5 C B 59 17.241 -1.947 -6.192 1.00 1.00 H +ATOM 1905 H6 C B 59 18.684 -2.200 -4.226 1.00 1.00 H +ATOM 1906 P G B 60 18.989 -5.164 0.647 1.00 1.00 P +ATOM 1907 OP1 G B 60 19.878 -5.850 1.611 1.00 1.00 O +ATOM 1908 OP2 G B 60 18.468 -5.899 -0.527 1.00 1.00 O +ATOM 1909 O5' G B 60 17.733 -4.555 1.461 1.00 1.00 O +ATOM 1910 C5' G B 60 17.936 -3.810 2.668 1.00 1.00 C +ATOM 1911 C4' G B 60 16.612 -3.368 3.300 1.00 1.00 C +ATOM 1912 O4' G B 60 15.997 -2.346 2.525 1.00 1.00 O +ATOM 1913 C3' G B 60 15.584 -4.475 3.443 1.00 1.00 C +ATOM 1914 O3' G B 60 15.757 -5.130 4.701 1.00 1.00 O +ATOM 1915 C2' G B 60 14.253 -3.739 3.412 1.00 1.00 C +ATOM 1916 O2' G B 60 13.758 -3.488 4.732 1.00 1.00 O +ATOM 1917 C1' G B 60 14.572 -2.439 2.678 1.00 1.00 C +ATOM 1918 N9 G B 60 13.984 -2.368 1.333 1.00 1.00 N +ATOM 1919 C8 G B 60 14.629 -2.353 0.124 1.00 1.00 C +ATOM 1920 N7 G B 60 13.827 -2.294 -0.903 1.00 1.00 N +ATOM 1921 C5 G B 60 12.557 -2.268 -0.335 1.00 1.00 C +ATOM 1922 C6 G B 60 11.280 -2.206 -0.960 1.00 1.00 C +ATOM 1923 O6 G B 60 11.020 -2.163 -2.160 1.00 1.00 O +ATOM 1924 N1 G B 60 10.255 -2.201 -0.024 1.00 1.00 N +ATOM 1925 C2 G B 60 10.431 -2.248 1.343 1.00 1.00 C +ATOM 1926 N2 G B 60 9.321 -2.235 2.079 1.00 1.00 N +ATOM 1927 N3 G B 60 11.629 -2.306 1.933 1.00 1.00 N +ATOM 1928 C4 G B 60 12.643 -2.312 1.035 1.00 1.00 C +ATOM 1929 H5' G B 60 18.532 -2.926 2.441 1.00 1.00 H +ATOM 1930 H5'' G B 60 18.480 -4.429 3.382 1.00 1.00 H +ATOM 1931 H4' G B 60 16.822 -2.962 4.289 1.00 1.00 H +ATOM 1932 H3' G B 60 15.656 -5.181 2.614 1.00 1.00 H +ATOM 1933 H2' G B 60 13.529 -4.314 2.834 1.00 1.00 H +ATOM 1934 HO2' G B 60 14.364 -2.875 5.153 1.00 1.00 H +ATOM 1935 H1' G B 60 14.215 -1.595 3.267 1.00 1.00 H +ATOM 1936 H8 G B 60 15.714 -2.388 0.028 1.00 1.00 H +ATOM 1937 H1 G B 60 9.317 -2.159 -0.394 1.00 1.00 H +ATOM 1938 H21 G B 60 8.417 -2.192 1.632 1.00 1.00 H +ATOM 1939 H22 G B 60 9.383 -2.269 3.088 1.00 1.00 H +ATOM 1940 P G B 61 15.113 -6.580 4.968 1.00 1.00 P +ATOM 1941 OP1 G B 61 15.649 -7.095 6.246 1.00 1.00 O +ATOM 1942 OP2 G B 61 15.250 -7.383 3.732 1.00 1.00 O +ATOM 1943 O5' G B 61 13.553 -6.238 5.174 1.00 1.00 O +ATOM 1944 C5' G B 61 13.130 -5.423 6.271 1.00 1.00 C +ATOM 1945 C4' G B 61 11.634 -5.125 6.210 1.00 1.00 C +ATOM 1946 O4' G B 61 11.316 -4.469 4.983 1.00 1.00 O +ATOM 1947 C3' G B 61 10.754 -6.360 6.291 1.00 1.00 C +ATOM 1948 O3' G B 61 10.401 -6.599 7.658 1.00 1.00 O +ATOM 1949 C2' G B 61 9.519 -5.975 5.491 1.00 1.00 C +ATOM 1950 O2' G B 61 8.497 -5.443 6.339 1.00 1.00 O +ATOM 1951 C1' G B 61 10.037 -4.922 4.513 1.00 1.00 C +ATOM 1952 N9 G B 61 10.229 -5.423 3.139 1.00 1.00 N +ATOM 1953 C8 G B 61 11.346 -5.995 2.588 1.00 1.00 C +ATOM 1954 N7 G B 61 11.204 -6.335 1.338 1.00 1.00 N +ATOM 1955 C5 G B 61 9.898 -5.962 1.033 1.00 1.00 C +ATOM 1956 C6 G B 61 9.176 -6.086 -0.187 1.00 1.00 C +ATOM 1957 O6 G B 61 9.559 -6.558 -1.256 1.00 1.00 O +ATOM 1958 N1 G B 61 7.887 -5.587 -0.068 1.00 1.00 N +ATOM 1959 C2 G B 61 7.354 -5.037 1.078 1.00 1.00 C +ATOM 1960 N2 G B 61 6.093 -4.612 0.996 1.00 1.00 N +ATOM 1961 N3 G B 61 8.029 -4.920 2.227 1.00 1.00 N +ATOM 1962 C4 G B 61 9.292 -5.403 2.130 1.00 1.00 C +ATOM 1963 H5' G B 61 13.681 -4.483 6.246 1.00 1.00 H +ATOM 1964 H5'' G B 61 13.352 -5.940 7.204 1.00 1.00 H +ATOM 1965 H4' G B 61 11.377 -4.457 7.030 1.00 1.00 H +ATOM 1966 H3' G B 61 11.252 -7.226 5.851 1.00 1.00 H +ATOM 1967 H2' G B 61 9.151 -6.840 4.938 1.00 1.00 H +ATOM 1968 HO2' G B 61 8.191 -4.627 5.938 1.00 1.00 H +ATOM 1969 H1' G B 61 9.345 -4.081 4.492 1.00 1.00 H +ATOM 1970 H8 G B 61 12.270 -6.150 3.145 1.00 1.00 H +ATOM 1971 H1 G B 61 7.311 -5.641 -0.896 1.00 1.00 H +ATOM 1972 H21 G B 61 5.587 -4.701 0.128 1.00 1.00 H +ATOM 1973 H22 G B 61 5.647 -4.199 1.802 1.00 1.00 H +ATOM 1974 P G B 62 10.001 -8.073 8.168 1.00 1.00 P +ATOM 1975 OP1 G B 62 9.855 -8.028 9.640 1.00 1.00 O +ATOM 1976 OP2 G B 62 10.930 -9.046 7.548 1.00 1.00 O +ATOM 1977 O5' G B 62 8.543 -8.289 7.522 1.00 1.00 O +ATOM 1978 C5' G B 62 7.461 -7.419 7.867 1.00 1.00 C +ATOM 1979 C4' G B 62 6.236 -7.680 6.997 1.00 1.00 C +ATOM 1980 O4' G B 62 6.531 -7.360 5.644 1.00 1.00 O +ATOM 1981 C3' G B 62 5.763 -9.124 7.011 1.00 1.00 C +ATOM 1982 O3' G B 62 4.769 -9.286 8.029 1.00 1.00 O +ATOM 1983 C2' G B 62 5.140 -9.315 5.634 1.00 1.00 C +ATOM 1984 O2' G B 62 3.721 -9.133 5.678 1.00 1.00 O +ATOM 1985 C1' G B 62 5.811 -8.241 4.772 1.00 1.00 C +ATOM 1986 N9 G B 62 6.782 -8.771 3.800 1.00 1.00 N +ATOM 1987 C8 G B 62 8.094 -9.111 4.000 1.00 1.00 C +ATOM 1988 N7 G B 62 8.695 -9.557 2.932 1.00 1.00 N +ATOM 1989 C5 G B 62 7.710 -9.511 1.950 1.00 1.00 C +ATOM 1990 C6 G B 62 7.774 -9.875 0.576 1.00 1.00 C +ATOM 1991 O6 G B 62 8.735 -10.317 -0.052 1.00 1.00 O +ATOM 1992 N1 G B 62 6.559 -9.673 -0.063 1.00 1.00 N +ATOM 1993 C2 G B 62 5.420 -9.184 0.541 1.00 1.00 C +ATOM 1994 N2 G B 62 4.345 -9.059 -0.237 1.00 1.00 N +ATOM 1995 N3 G B 62 5.356 -8.841 1.833 1.00 1.00 N +ATOM 1996 C4 G B 62 6.535 -9.030 2.472 1.00 1.00 C +ATOM 1997 H5' G B 62 7.780 -6.386 7.733 1.00 1.00 H +ATOM 1998 H5'' G B 62 7.196 -7.578 8.912 1.00 1.00 H +ATOM 1999 H4' G B 62 5.423 -7.040 7.332 1.00 1.00 H +ATOM 2000 H3' G B 62 6.602 -9.806 7.159 1.00 1.00 H +ATOM 2001 H2' G B 62 5.389 -10.308 5.250 1.00 1.00 H +ATOM 2002 HO2' G B 62 3.324 -10.005 5.739 1.00 1.00 H +ATOM 2003 H1' G B 62 5.046 -7.677 4.241 1.00 1.00 H +ATOM 2004 H8 G B 62 8.593 -9.015 4.964 1.00 1.00 H +ATOM 2005 H1 G B 62 6.527 -9.910 -1.044 1.00 1.00 H +ATOM 2006 H21 G B 62 4.396 -9.318 -1.211 1.00 1.00 H +ATOM 2007 H22 G B 62 3.482 -8.706 0.148 1.00 1.00 H +ATOM 2008 P G B 63 4.639 -10.672 8.838 1.00 1.00 P +ATOM 2009 OP1 G B 63 3.647 -10.485 9.920 1.00 1.00 O +ATOM 2010 OP2 G B 63 6.003 -11.148 9.163 1.00 1.00 O +ATOM 2011 O5' G B 63 4.008 -11.666 7.741 1.00 1.00 O +ATOM 2012 C5' G B 63 4.376 -13.047 7.727 1.00 1.00 C +ATOM 2013 C4' G B 63 4.028 -13.708 6.395 1.00 1.00 C +ATOM 2014 O4' G B 63 4.371 -12.836 5.315 1.00 1.00 O +ATOM 2015 C3' G B 63 4.747 -15.030 6.162 1.00 1.00 C +ATOM 2016 O3' G B 63 3.883 -16.112 6.525 1.00 1.00 O +ATOM 2017 C2' G B 63 5.000 -15.050 4.663 1.00 1.00 C +ATOM 2018 O2' G B 63 3.948 -15.727 3.966 1.00 1.00 O +ATOM 2019 C1' G B 63 5.053 -13.571 4.289 1.00 1.00 C +ATOM 2020 N9 G B 63 6.418 -13.024 4.196 1.00 1.00 N +ATOM 2021 C8 G B 63 7.208 -12.536 5.205 1.00 1.00 C +ATOM 2022 N7 G B 63 8.378 -12.124 4.809 1.00 1.00 N +ATOM 2023 C5 G B 63 8.369 -12.353 3.437 1.00 1.00 C +ATOM 2024 C6 G B 63 9.376 -12.101 2.466 1.00 1.00 C +ATOM 2025 O6 G B 63 10.495 -11.620 2.633 1.00 1.00 O +ATOM 2026 N1 G B 63 8.963 -12.477 1.195 1.00 1.00 N +ATOM 2027 C2 G B 63 7.735 -13.025 0.892 1.00 1.00 C +ATOM 2028 N2 G B 63 7.524 -13.319 -0.390 1.00 1.00 N +ATOM 2029 N3 G B 63 6.786 -13.264 1.804 1.00 1.00 N +ATOM 2030 C4 G B 63 7.172 -12.904 3.051 1.00 1.00 C +ATOM 2031 H5' G B 63 3.847 -13.563 8.528 1.00 1.00 H +ATOM 2032 H5'' G B 63 5.448 -13.130 7.898 1.00 1.00 H +ATOM 2033 H4' G B 63 2.954 -13.884 6.364 1.00 1.00 H +ATOM 2034 H3' G B 63 5.685 -15.067 6.717 1.00 1.00 H +ATOM 2035 H2' G B 63 5.965 -15.520 4.456 1.00 1.00 H +ATOM 2036 HO2' G B 63 3.211 -15.116 3.898 1.00 1.00 H +ATOM 2037 H1' G B 63 4.542 -13.421 3.338 1.00 1.00 H +ATOM 2038 H8 G B 63 6.886 -12.497 6.246 1.00 1.00 H +ATOM 2039 H1 G B 63 9.628 -12.327 0.449 1.00 1.00 H +ATOM 2040 H21 G B 63 8.245 -13.136 -1.076 1.00 1.00 H +ATOM 2041 H22 G B 63 6.650 -13.720 -0.676 1.00 1.00 H +ATOM 2042 P A B 64 4.429 -17.334 7.420 1.00 1.00 P +ATOM 2043 OP1 A B 64 3.269 -18.133 7.871 1.00 1.00 O +ATOM 2044 OP2 A B 64 5.383 -16.791 8.413 1.00 1.00 O +ATOM 2045 O5' A B 64 5.258 -18.210 6.354 1.00 1.00 O +ATOM 2046 C5' A B 64 6.341 -19.040 6.785 1.00 1.00 C +ATOM 2047 C4' A B 64 6.821 -19.958 5.664 1.00 1.00 C +ATOM 2048 O4' A B 64 5.818 -20.941 5.389 1.00 1.00 O +ATOM 2049 C3' A B 64 7.127 -19.226 4.360 1.00 1.00 C +ATOM 2050 O3' A B 64 8.545 -19.118 4.196 1.00 1.00 O +ATOM 2051 C2' A B 64 6.555 -20.126 3.274 1.00 1.00 C +ATOM 2052 O2' A B 64 7.558 -20.992 2.733 1.00 1.00 O +ATOM 2053 C1' A B 64 5.476 -20.915 4.001 1.00 1.00 C +ATOM 2054 N9 A B 64 4.127 -20.330 3.882 1.00 1.00 N +ATOM 2055 C8 A B 64 3.432 -19.577 4.793 1.00 1.00 C +ATOM 2056 N7 A B 64 2.248 -19.212 4.383 1.00 1.00 N +ATOM 2057 C5 A B 64 2.152 -19.763 3.109 1.00 1.00 C +ATOM 2058 C6 A B 64 1.134 -19.738 2.141 1.00 1.00 C +ATOM 2059 N6 A B 64 -0.026 -19.105 2.318 1.00 1.00 N +ATOM 2060 N1 A B 64 1.365 -20.389 0.990 1.00 1.00 N +ATOM 2061 C2 A B 64 2.523 -21.016 0.820 1.00 1.00 C +ATOM 2062 N3 A B 64 3.553 -21.110 1.649 1.00 1.00 N +ATOM 2063 C4 A B 64 3.291 -20.448 2.796 1.00 1.00 C +ATOM 2064 H5' A B 64 6.009 -19.648 7.627 1.00 1.00 H +ATOM 2065 H5'' A B 64 7.167 -18.406 7.107 1.00 1.00 H +ATOM 2066 H4' A B 64 7.722 -20.472 5.996 1.00 1.00 H +ATOM 2067 H3' A B 64 6.650 -18.244 4.344 1.00 1.00 H +ATOM 2068 H2' A B 64 6.103 -19.519 2.486 1.00 1.00 H +ATOM 2069 HO2' A B 64 7.984 -20.521 2.012 1.00 1.00 H +ATOM 2070 H1' A B 64 5.458 -21.933 3.615 1.00 1.00 H +ATOM 2071 H8 A B 64 3.831 -19.309 5.770 1.00 1.00 H +ATOM 2072 H61 A B 64 -0.724 -19.118 1.588 1.00 1.00 H +ATOM 2073 H62 A B 64 -0.206 -18.613 3.182 1.00 1.00 H +ATOM 2074 H2 A B 64 2.644 -21.524 -0.137 1.00 1.00 H +ATOM 2075 P A B 65 9.178 -17.939 3.299 1.00 1.00 P +ATOM 2076 OP1 A B 65 10.492 -17.575 3.876 1.00 1.00 O +ATOM 2077 OP2 A B 65 8.146 -16.898 3.103 1.00 1.00 O +ATOM 2078 O5' A B 65 9.432 -18.668 1.888 1.00 1.00 O +ATOM 2079 C5' A B 65 8.990 -18.064 0.672 1.00 1.00 C +ATOM 2080 C4' A B 65 8.061 -18.993 -0.105 1.00 1.00 C +ATOM 2081 O4' A B 65 6.912 -19.289 0.692 1.00 1.00 O +ATOM 2082 C3' A B 65 7.564 -18.408 -1.421 1.00 1.00 C +ATOM 2083 O3' A B 65 8.379 -18.881 -2.501 1.00 1.00 O +ATOM 2084 C2' A B 65 6.157 -18.967 -1.557 1.00 1.00 C +ATOM 2085 O2' A B 65 6.153 -20.182 -2.316 1.00 1.00 O +ATOM 2086 C1' A B 65 5.729 -19.215 -0.112 1.00 1.00 C +ATOM 2087 N9 A B 65 4.869 -18.155 0.449 1.00 1.00 N +ATOM 2088 C8 A B 65 5.129 -17.284 1.476 1.00 1.00 C +ATOM 2089 N7 A B 65 4.152 -16.452 1.720 1.00 1.00 N +ATOM 2090 C5 A B 65 3.178 -16.801 0.788 1.00 1.00 C +ATOM 2091 C6 A B 65 1.895 -16.296 0.519 1.00 1.00 C +ATOM 2092 N6 A B 65 1.350 -15.285 1.197 1.00 1.00 N +ATOM 2093 N1 A B 65 1.200 -16.876 -0.475 1.00 1.00 N +ATOM 2094 C2 A B 65 1.748 -17.881 -1.147 1.00 1.00 C +ATOM 2095 N3 A B 65 2.937 -18.440 -0.990 1.00 1.00 N +ATOM 2096 C4 A B 65 3.608 -17.837 0.012 1.00 1.00 C +ATOM 2097 H5' A B 65 9.855 -17.827 0.054 1.00 1.00 H +ATOM 2098 H5'' A B 65 8.456 -17.142 0.905 1.00 1.00 H +ATOM 2099 H4' A B 65 8.587 -19.923 -0.311 1.00 1.00 H +ATOM 2100 H3' A B 65 7.550 -17.318 -1.382 1.00 1.00 H +ATOM 2101 H2' A B 65 5.504 -18.223 -2.016 1.00 1.00 H +ATOM 2102 HO2' A B 65 6.744 -20.055 -3.061 1.00 1.00 H +ATOM 2103 H1' A B 65 5.200 -20.166 -0.054 1.00 1.00 H +ATOM 2104 H8 A B 65 6.065 -17.284 2.037 1.00 1.00 H +ATOM 2105 H61 A B 65 0.423 -14.962 0.963 1.00 1.00 H +ATOM 2106 H62 A B 65 1.865 -14.844 1.947 1.00 1.00 H +ATOM 2107 H2 A B 65 1.131 -18.306 -1.940 1.00 1.00 H +ATOM 2108 P A B 66 8.904 -17.871 -3.643 1.00 1.00 P +ATOM 2109 OP1 A B 66 9.637 -18.661 -4.656 1.00 1.00 O +ATOM 2110 OP2 A B 66 9.570 -16.728 -2.978 1.00 1.00 O +ATOM 2111 O5' A B 66 7.539 -17.335 -4.315 1.00 1.00 O +ATOM 2112 C5' A B 66 6.920 -18.047 -5.394 1.00 1.00 C +ATOM 2113 C4' A B 66 5.528 -17.497 -5.705 1.00 1.00 C +ATOM 2114 O4' A B 66 4.719 -17.561 -4.531 1.00 1.00 O +ATOM 2115 C3' A B 66 5.523 -16.048 -6.172 1.00 1.00 C +ATOM 2116 O3' A B 66 5.524 -15.993 -7.602 1.00 1.00 O +ATOM 2117 C2' A B 66 4.203 -15.505 -5.646 1.00 1.00 C +ATOM 2118 O2' A B 66 3.164 -15.621 -6.626 1.00 1.00 O +ATOM 2119 C1' A B 66 3.919 -16.376 -4.426 1.00 1.00 C +ATOM 2120 N9 A B 66 4.258 -15.729 -3.150 1.00 1.00 N +ATOM 2121 C8 A B 66 5.478 -15.660 -2.528 1.00 1.00 C +ATOM 2122 N7 A B 66 5.462 -14.997 -1.405 1.00 1.00 N +ATOM 2123 C5 A B 66 4.135 -14.599 -1.273 1.00 1.00 C +ATOM 2124 C6 A B 66 3.459 -13.857 -0.290 1.00 1.00 C +ATOM 2125 N6 A B 66 4.060 -13.360 0.792 1.00 1.00 N +ATOM 2126 N1 A B 66 2.146 -13.649 -0.472 1.00 1.00 N +ATOM 2127 C2 A B 66 1.554 -14.142 -1.553 1.00 1.00 C +ATOM 2128 N3 A B 66 2.078 -14.848 -2.543 1.00 1.00 N +ATOM 2129 C4 A B 66 3.396 -15.042 -2.332 1.00 1.00 C +ATOM 2130 H5' A B 66 6.835 -19.100 -5.124 1.00 1.00 H +ATOM 2131 H5'' A B 66 7.545 -17.956 -6.283 1.00 1.00 H +ATOM 2132 H4' A B 66 5.068 -18.116 -6.472 1.00 1.00 H +ATOM 2133 H3' A B 66 6.366 -15.497 -5.751 1.00 1.00 H +ATOM 2134 H2' A B 66 4.327 -14.465 -5.336 1.00 1.00 H +ATOM 2135 HO2' A B 66 3.411 -16.333 -7.221 1.00 1.00 H +ATOM 2136 H1' A B 66 2.867 -16.655 -4.416 1.00 1.00 H +ATOM 2137 H8 A B 66 6.381 -16.119 -2.935 1.00 1.00 H +ATOM 2138 H61 A B 66 3.525 -12.832 1.468 1.00 1.00 H +ATOM 2139 H62 A B 66 5.054 -13.510 0.940 1.00 1.00 H +ATOM 2140 H2 A B 66 0.488 -13.935 -1.637 1.00 1.00 H +ATOM 2141 P C B 67 6.290 -14.804 -8.374 1.00 1.00 P +ATOM 2142 OP1 C B 67 6.127 -15.018 -9.829 1.00 1.00 O +ATOM 2143 OP2 C B 67 7.647 -14.675 -7.796 1.00 1.00 O +ATOM 2144 O5' C B 67 5.439 -13.501 -7.957 1.00 1.00 O +ATOM 2145 C5' C B 67 4.035 -13.432 -8.217 1.00 1.00 C +ATOM 2146 C4' C B 67 3.324 -12.513 -7.224 1.00 1.00 C +ATOM 2147 O4' C B 67 3.628 -12.923 -5.890 1.00 1.00 O +ATOM 2148 C3' C B 67 3.716 -11.045 -7.327 1.00 1.00 C +ATOM 2149 O3' C B 67 2.819 -10.360 -8.209 1.00 1.00 O +ATOM 2150 C2' C B 67 3.532 -10.529 -5.911 1.00 1.00 C +ATOM 2151 O2' C B 67 2.219 -9.990 -5.719 1.00 1.00 O +ATOM 2152 C1' C B 67 3.758 -11.767 -5.051 1.00 1.00 C +ATOM 2153 N1 C B 67 5.092 -11.814 -4.425 1.00 1.00 N +ATOM 2154 C2 C B 67 5.249 -11.159 -3.213 1.00 1.00 C +ATOM 2155 O2 C B 67 4.299 -10.570 -2.704 1.00 1.00 O +ATOM 2156 N3 C B 67 6.474 -11.188 -2.618 1.00 1.00 N +ATOM 2157 C4 C B 67 7.500 -11.833 -3.187 1.00 1.00 C +ATOM 2158 N4 C B 67 8.686 -11.842 -2.578 1.00 1.00 N +ATOM 2159 C5 C B 67 7.342 -12.510 -4.438 1.00 1.00 C +ATOM 2160 C6 C B 67 6.127 -12.476 -5.019 1.00 1.00 C +ATOM 2161 H5' C B 67 3.610 -14.433 -8.143 1.00 1.00 H +ATOM 2162 H5'' C B 67 3.879 -13.053 -9.228 1.00 1.00 H +ATOM 2163 H4' C B 67 2.249 -12.602 -7.371 1.00 1.00 H +ATOM 2164 H3' C B 67 4.753 -10.939 -7.651 1.00 1.00 H +ATOM 2165 H2' C B 67 4.293 -9.781 -5.687 1.00 1.00 H +ATOM 2166 HO2' C B 67 1.608 -10.731 -5.698 1.00 1.00 H +ATOM 2167 H1' C B 67 2.998 -11.803 -4.272 1.00 1.00 H +ATOM 2168 H41 C B 67 8.804 -11.367 -1.695 1.00 1.00 H +ATOM 2169 H42 C B 67 9.467 -12.325 -2.997 1.00 1.00 H +ATOM 2170 H5 C B 67 8.177 -13.035 -4.905 1.00 1.00 H +ATOM 2171 H6 C B 67 5.970 -12.981 -5.972 1.00 1.00 H +ATOM 2172 P U B 68 3.253 -8.976 -8.914 1.00 1.00 P +ATOM 2173 OP1 U B 68 2.157 -8.551 -9.812 1.00 1.00 O +ATOM 2174 OP2 U B 68 4.623 -9.141 -9.449 1.00 1.00 O +ATOM 2175 O5' U B 68 3.319 -7.946 -7.674 1.00 1.00 O +ATOM 2176 C5' U B 68 2.148 -7.651 -6.907 1.00 1.00 C +ATOM 2177 C4' U B 68 2.477 -6.830 -5.659 1.00 1.00 C +ATOM 2178 O4' U B 68 3.356 -7.563 -4.809 1.00 1.00 O +ATOM 2179 C3' U B 68 3.166 -5.504 -5.936 1.00 1.00 C +ATOM 2180 O3' U B 68 2.187 -4.476 -6.121 1.00 1.00 O +ATOM 2181 C2' U B 68 3.955 -5.246 -4.663 1.00 1.00 C +ATOM 2182 O2' U B 68 3.208 -4.448 -3.739 1.00 1.00 O +ATOM 2183 C1' U B 68 4.213 -6.646 -4.109 1.00 1.00 C +ATOM 2184 N1 U B 68 5.605 -7.105 -4.291 1.00 1.00 N +ATOM 2185 C2 U B 68 6.488 -6.920 -3.244 1.00 1.00 C +ATOM 2186 O2 U B 68 6.150 -6.381 -2.192 1.00 1.00 O +ATOM 2187 N3 U B 68 7.778 -7.375 -3.448 1.00 1.00 N +ATOM 2188 C4 U B 68 8.255 -7.992 -4.593 1.00 1.00 C +ATOM 2189 O4 U B 68 9.426 -8.358 -4.666 1.00 1.00 O +ATOM 2190 C5 U B 68 7.265 -8.144 -5.636 1.00 1.00 C +ATOM 2191 C6 U B 68 5.994 -7.706 -5.458 1.00 1.00 C +ATOM 2192 H5' U B 68 1.678 -8.587 -6.602 1.00 1.00 H +ATOM 2193 H5'' U B 68 1.448 -7.090 -7.527 1.00 1.00 H +ATOM 2194 H4' U B 68 1.555 -6.638 -5.113 1.00 1.00 H +ATOM 2195 H3' U B 68 3.831 -5.584 -6.799 1.00 1.00 H +ATOM 2196 H2' U B 68 4.902 -4.771 -4.906 1.00 1.00 H +ATOM 2197 HO2' U B 68 3.781 -4.269 -2.990 1.00 1.00 H +ATOM 2198 H1' U B 68 3.964 -6.663 -3.047 1.00 1.00 H +ATOM 2199 H3 U B 68 8.434 -7.246 -2.692 1.00 1.00 H +ATOM 2200 H5 U B 68 7.543 -8.618 -6.577 1.00 1.00 H +ATOM 2201 H6 U B 68 5.268 -7.832 -6.261 1.00 1.00 H +ATOM 2202 P U B 69 2.594 -3.061 -6.777 1.00 1.00 P +ATOM 2203 OP1 U B 69 1.367 -2.420 -7.301 1.00 1.00 O +ATOM 2204 OP2 U B 69 3.751 -3.279 -7.672 1.00 1.00 O +ATOM 2205 O5' U B 69 3.098 -2.216 -5.502 1.00 1.00 O +ATOM 2206 C5' U B 69 2.225 -1.977 -4.397 1.00 1.00 C +ATOM 2207 C4' U B 69 2.994 -1.489 -3.169 1.00 1.00 C +ATOM 2208 O4' U B 69 3.910 -2.495 -2.730 1.00 1.00 O +ATOM 2209 C3' U B 69 3.824 -0.242 -3.403 1.00 1.00 C +ATOM 2210 O3' U B 69 3.035 0.931 -3.170 1.00 1.00 O +ATOM 2211 C2' U B 69 4.915 -0.360 -2.354 1.00 1.00 C +ATOM 2212 O2' U B 69 4.538 0.256 -1.118 1.00 1.00 O +ATOM 2213 C1' U B 69 5.087 -1.861 -2.194 1.00 1.00 C +ATOM 2214 N1 U B 69 6.262 -2.386 -2.922 1.00 1.00 N +ATOM 2215 C2 U B 69 7.441 -2.544 -2.217 1.00 1.00 C +ATOM 2216 O2 U B 69 7.539 -2.242 -1.029 1.00 1.00 O +ATOM 2217 N3 U B 69 8.509 -3.061 -2.927 1.00 1.00 N +ATOM 2218 C4 U B 69 8.500 -3.429 -4.263 1.00 1.00 C +ATOM 2219 O4 U B 69 9.511 -3.880 -4.796 1.00 1.00 O +ATOM 2220 C5 U B 69 7.226 -3.230 -4.918 1.00 1.00 C +ATOM 2221 C6 U B 69 6.166 -2.726 -4.242 1.00 1.00 C +ATOM 2222 H5' U B 69 1.704 -2.902 -4.148 1.00 1.00 H +ATOM 2223 H5'' U B 69 1.490 -1.221 -4.681 1.00 1.00 H +ATOM 2224 H4' U B 69 2.285 -1.295 -2.365 1.00 1.00 H +ATOM 2225 H3' U B 69 4.251 -0.244 -4.407 1.00 1.00 H +ATOM 2226 H2' U B 69 5.837 0.061 -2.734 1.00 1.00 H +ATOM 2227 HO2' U B 69 5.337 0.361 -0.593 1.00 1.00 H +ATOM 2228 H1' U B 69 5.177 -2.104 -1.135 1.00 1.00 H +ATOM 2229 H3 U B 69 9.378 -3.182 -2.426 1.00 1.00 H +ATOM 2230 H5 U B 69 7.119 -3.488 -5.973 1.00 1.00 H +ATOM 2231 H6 U B 69 5.217 -2.590 -4.761 1.00 1.00 H +ATOM 2232 P G B 70 3.439 2.342 -3.838 1.00 1.00 P +ATOM 2233 OP1 G B 70 2.417 3.342 -3.462 1.00 1.00 O +ATOM 2234 OP2 G B 70 3.754 2.107 -5.266 1.00 1.00 O +ATOM 2235 O5' G B 70 4.807 2.709 -3.073 1.00 1.00 O +ATOM 2236 C5' G B 70 4.837 2.733 -1.646 1.00 1.00 C +ATOM 2237 C4' G B 70 6.257 2.607 -1.099 1.00 1.00 C +ATOM 2238 O4' G B 70 6.914 1.488 -1.688 1.00 1.00 O +ATOM 2239 C3' G B 70 7.158 3.803 -1.367 1.00 1.00 C +ATOM 2240 O3' G B 70 7.032 4.752 -0.295 1.00 1.00 O +ATOM 2241 C2' G B 70 8.550 3.194 -1.333 1.00 1.00 C +ATOM 2242 O2' G B 70 9.172 3.375 -0.055 1.00 1.00 O +ATOM 2243 C1' G B 70 8.325 1.719 -1.633 1.00 1.00 C +ATOM 2244 N9 G B 70 8.955 1.271 -2.887 1.00 1.00 N +ATOM 2245 C8 G B 70 8.380 0.825 -4.050 1.00 1.00 C +ATOM 2246 N7 G B 70 9.240 0.426 -4.945 1.00 1.00 N +ATOM 2247 C5 G B 70 10.476 0.625 -4.334 1.00 1.00 C +ATOM 2248 C6 G B 70 11.787 0.374 -4.825 1.00 1.00 C +ATOM 2249 O6 G B 70 12.119 -0.089 -5.913 1.00 1.00 O +ATOM 2250 N1 G B 70 12.754 0.719 -3.890 1.00 1.00 N +ATOM 2251 C2 G B 70 12.495 1.239 -2.638 1.00 1.00 C +ATOM 2252 N2 G B 70 13.554 1.516 -1.881 1.00 1.00 N +ATOM 2253 N3 G B 70 11.264 1.473 -2.177 1.00 1.00 N +ATOM 2254 C4 G B 70 10.308 1.145 -3.075 1.00 1.00 C +ATOM 2255 H5' G B 70 4.237 1.905 -1.269 1.00 1.00 H +ATOM 2256 H5'' G B 70 4.403 3.671 -1.299 1.00 1.00 H +ATOM 2257 H4' G B 70 6.204 2.444 -0.024 1.00 1.00 H +ATOM 2258 H3' G B 70 6.946 4.254 -2.336 1.00 1.00 H +ATOM 2259 H2' G B 70 9.163 3.632 -2.124 1.00 1.00 H +ATOM 2260 HO2' G B 70 8.497 3.236 0.611 1.00 1.00 H +ATOM 2261 H1' G B 70 8.737 1.131 -0.814 1.00 1.00 H +ATOM 2262 H8 G B 70 7.302 0.809 -4.213 1.00 1.00 H +ATOM 2263 H1 G B 70 13.713 0.566 -4.165 1.00 1.00 H +ATOM 2264 H21 G B 70 14.488 1.339 -2.229 1.00 1.00 H +ATOM 2265 H22 G B 70 13.426 1.899 -0.954 1.00 1.00 H +ATOM 2266 P G B 71 7.658 6.235 -0.417 1.00 1.00 P +ATOM 2267 OP1 G B 71 6.852 7.145 0.430 1.00 1.00 O +ATOM 2268 OP2 G B 71 7.849 6.544 -1.851 1.00 1.00 O +ATOM 2269 O5' G B 71 9.115 6.077 0.260 1.00 1.00 O +ATOM 2270 C5' G B 71 9.275 6.083 1.684 1.00 1.00 C +ATOM 2271 C4' G B 71 10.751 6.164 2.091 1.00 1.00 C +ATOM 2272 O4' G B 71 11.425 4.945 1.755 1.00 1.00 O +ATOM 2273 C3' G B 71 11.517 7.299 1.423 1.00 1.00 C +ATOM 2274 O3' G B 71 11.545 8.444 2.286 1.00 1.00 O +ATOM 2275 C2' G B 71 12.919 6.737 1.253 1.00 1.00 C +ATOM 2276 O2' G B 71 13.749 7.031 2.381 1.00 1.00 O +ATOM 2277 C1' G B 71 12.674 5.244 1.114 1.00 1.00 C +ATOM 2278 N9 G B 71 12.566 4.796 -0.281 1.00 1.00 N +ATOM 2279 C8 G B 71 11.428 4.553 -1.007 1.00 1.00 C +ATOM 2280 N7 G B 71 11.652 4.161 -2.229 1.00 1.00 N +ATOM 2281 C5 G B 71 13.040 4.139 -2.325 1.00 1.00 C +ATOM 2282 C6 G B 71 13.868 3.792 -3.427 1.00 1.00 C +ATOM 2283 O6 G B 71 13.530 3.429 -4.552 1.00 1.00 O +ATOM 2284 N1 G B 71 15.214 3.905 -3.107 1.00 1.00 N +ATOM 2285 C2 G B 71 15.705 4.302 -1.882 1.00 1.00 C +ATOM 2286 N2 G B 71 17.032 4.348 -1.768 1.00 1.00 N +ATOM 2287 N3 G B 71 14.928 4.631 -0.843 1.00 1.00 N +ATOM 2288 C4 G B 71 13.610 4.527 -1.138 1.00 1.00 C +ATOM 2289 H5' G B 71 8.842 5.169 2.094 1.00 1.00 H +ATOM 2290 H5'' G B 71 8.745 6.942 2.098 1.00 1.00 H +ATOM 2291 H4' G B 71 10.806 6.295 3.170 1.00 1.00 H +ATOM 2292 H3' G B 71 11.078 7.545 0.453 1.00 1.00 H +ATOM 2293 H2' G B 71 13.364 7.118 0.334 1.00 1.00 H +ATOM 2294 HO2' G B 71 14.654 6.830 2.130 1.00 1.00 H +ATOM 2295 H1' G B 71 13.478 4.696 1.605 1.00 1.00 H +ATOM 2296 H8 G B 71 10.425 4.672 -0.597 1.00 1.00 H +ATOM 2297 H1 G B 71 15.865 3.672 -3.841 1.00 1.00 H +ATOM 2298 H21 G B 71 17.615 4.098 -2.555 1.00 1.00 H +ATOM 2299 H22 G B 71 17.455 4.631 -0.897 1.00 1.00 H +ATOM 2300 P U B 72 11.655 9.936 1.679 1.00 1.00 P +ATOM 2301 OP1 U B 72 11.460 10.899 2.785 1.00 1.00 O +ATOM 2302 OP2 U B 72 10.794 10.010 0.479 1.00 1.00 O +ATOM 2303 O5' U B 72 13.192 10.029 1.199 1.00 1.00 O +ATOM 2304 C5' U B 72 14.241 10.252 2.149 1.00 1.00 C +ATOM 2305 C4' U B 72 15.609 10.357 1.472 1.00 1.00 C +ATOM 2306 O4' U B 72 15.939 9.119 0.847 1.00 1.00 O +ATOM 2307 C3' U B 72 15.703 11.420 0.389 1.00 1.00 C +ATOM 2308 O3' U B 72 16.108 12.671 0.961 1.00 1.00 O +ATOM 2309 C2' U B 72 16.792 10.882 -0.524 1.00 1.00 C +ATOM 2310 O2' U B 72 18.091 11.339 -0.127 1.00 1.00 O +ATOM 2311 C1' U B 72 16.654 9.371 -0.375 1.00 1.00 C +ATOM 2312 N1 U B 72 15.888 8.741 -1.471 1.00 1.00 N +ATOM 2313 C2 U B 72 16.594 8.246 -2.550 1.00 1.00 C +ATOM 2314 O2 U B 72 17.818 8.327 -2.623 1.00 1.00 O +ATOM 2315 N3 U B 72 15.841 7.653 -3.547 1.00 1.00 N +ATOM 2316 C4 U B 72 14.463 7.515 -3.560 1.00 1.00 C +ATOM 2317 O4 U B 72 13.897 6.968 -4.504 1.00 1.00 O +ATOM 2318 C5 U B 72 13.808 8.061 -2.392 1.00 1.00 C +ATOM 2319 C6 U B 72 14.524 8.646 -1.401 1.00 1.00 C +ATOM 2320 H5' U B 72 14.258 9.423 2.857 1.00 1.00 H +ATOM 2321 H5'' U B 72 14.038 11.177 2.689 1.00 1.00 H +ATOM 2322 H4' U B 72 16.359 10.565 2.233 1.00 1.00 H +ATOM 2323 H3' U B 72 14.756 11.514 -0.147 1.00 1.00 H +ATOM 2324 H2' U B 72 16.582 11.163 -1.550 1.00 1.00 H +ATOM 2325 HO2' U B 72 18.201 11.121 0.801 1.00 1.00 H +ATOM 2326 H1' U B 72 17.643 8.919 -0.318 1.00 1.00 H +ATOM 2327 H3 U B 72 16.345 7.287 -4.343 1.00 1.00 H +ATOM 2328 H5 U B 72 12.723 8.000 -2.308 1.00 1.00 H +ATOM 2329 H6 U B 72 14.004 9.049 -0.533 1.00 1.00 H +ATOM 2330 P U B 73 15.718 14.071 0.260 1.00 1.00 P +ATOM 2331 OP1 U B 73 16.152 15.169 1.153 1.00 1.00 O +ATOM 2332 OP2 U B 73 14.305 13.992 -0.174 1.00 1.00 O +ATOM 2333 O5' U B 73 16.646 14.098 -1.059 1.00 1.00 O +ATOM 2334 C5' U B 73 18.038 14.422 -0.966 1.00 1.00 C +ATOM 2335 C4' U B 73 18.733 14.352 -2.328 1.00 1.00 C +ATOM 2336 O4' U B 73 18.705 13.020 -2.827 1.00 1.00 O +ATOM 2337 C3' U B 73 18.107 15.222 -3.406 1.00 1.00 C +ATOM 2338 O3' U B 73 18.674 16.537 -3.362 1.00 1.00 O +ATOM 2339 C2' U B 73 18.525 14.516 -4.684 1.00 1.00 C +ATOM 2340 O2' U B 73 19.810 14.964 -5.131 1.00 1.00 O +ATOM 2341 C1' U B 73 18.562 13.049 -4.257 1.00 1.00 C +ATOM 2342 N1 U B 73 17.333 12.306 -4.581 1.00 1.00 N +ATOM 2343 C2 U B 73 17.332 11.540 -5.732 1.00 1.00 C +ATOM 2344 O2 U B 73 18.301 11.493 -6.487 1.00 1.00 O +ATOM 2345 N3 U B 73 16.173 10.830 -5.986 1.00 1.00 N +ATOM 2346 C4 U B 73 15.032 10.819 -5.202 1.00 1.00 C +ATOM 2347 O4 U B 73 14.056 10.145 -5.524 1.00 1.00 O +ATOM 2348 C5 U B 73 15.122 11.649 -4.022 1.00 1.00 C +ATOM 2349 C6 U B 73 16.247 12.353 -3.751 1.00 1.00 C +ATOM 2350 H5' U B 73 18.519 13.720 -0.286 1.00 1.00 H +ATOM 2351 H5'' U B 73 18.140 15.430 -0.564 1.00 1.00 H +ATOM 2352 H4' U B 73 19.774 14.647 -2.202 1.00 1.00 H +ATOM 2353 H3' U B 73 17.020 15.247 -3.310 1.00 1.00 H +ATOM 2354 H2' U B 73 17.770 14.661 -5.459 1.00 1.00 H +ATOM 2355 HO2' U B 73 20.205 14.246 -5.635 1.00 1.00 H +ATOM 2356 H1' U B 73 19.418 12.554 -4.716 1.00 1.00 H +ATOM 2357 H3 U B 73 16.158 10.264 -6.824 1.00 1.00 H +ATOM 2358 H5 U B 73 14.273 11.708 -3.340 1.00 1.00 H +ATOM 2359 H6 U B 73 16.286 12.973 -2.855 1.00 1.00 H +ATOM 2360 P C B 74 17.831 17.819 -3.857 1.00 1.00 P +ATOM 2361 OP1 C B 74 18.761 18.964 -3.968 1.00 1.00 O +ATOM 2362 OP2 C B 74 16.620 17.931 -3.015 1.00 1.00 O +ATOM 2363 O5' C B 74 17.374 17.398 -5.342 1.00 1.00 O +ATOM 2364 C5' C B 74 18.280 17.512 -6.440 1.00 1.00 C +ATOM 2365 C4' C B 74 17.644 17.035 -7.745 1.00 1.00 C +ATOM 2366 O4' C B 74 17.380 15.637 -7.683 1.00 1.00 O +ATOM 2367 C3' C B 74 16.316 17.687 -8.077 1.00 1.00 C +ATOM 2368 O3' C B 74 16.527 18.923 -8.766 1.00 1.00 O +ATOM 2369 C2' C B 74 15.678 16.671 -9.011 1.00 1.00 C +ATOM 2370 O2' C B 74 16.030 16.918 -10.379 1.00 1.00 O +ATOM 2371 C1' C B 74 16.246 15.340 -8.513 1.00 1.00 C +ATOM 2372 N1 C B 74 15.294 14.549 -7.703 1.00 1.00 N +ATOM 2373 C2 C B 74 14.573 13.559 -8.351 1.00 1.00 C +ATOM 2374 O2 C B 74 14.719 13.382 -9.559 1.00 1.00 O +ATOM 2375 N3 C B 74 13.709 12.805 -7.617 1.00 1.00 N +ATOM 2376 C4 C B 74 13.558 13.015 -6.302 1.00 1.00 C +ATOM 2377 N4 C B 74 12.703 12.257 -5.612 1.00 1.00 N +ATOM 2378 C5 C B 74 14.300 14.037 -5.630 1.00 1.00 C +ATOM 2379 C6 C B 74 15.152 14.777 -6.365 1.00 1.00 C +ATOM 2380 H5' C B 74 19.164 16.909 -6.235 1.00 1.00 H +ATOM 2381 H5'' C B 74 18.579 18.555 -6.550 1.00 1.00 H +ATOM 2382 H4' C B 74 18.340 17.215 -8.563 1.00 1.00 H +ATOM 2383 H3' C B 74 15.712 17.825 -7.179 1.00 1.00 H +ATOM 2384 H2' C B 74 14.601 16.681 -8.884 1.00 1.00 H +ATOM 2385 HO2' C B 74 16.978 17.065 -10.409 1.00 1.00 H +ATOM 2386 H1' C B 74 16.575 14.743 -9.364 1.00 1.00 H +ATOM 2387 H41 C B 74 12.177 11.536 -6.081 1.00 1.00 H +ATOM 2388 H42 C B 74 12.582 12.408 -4.622 1.00 1.00 H +ATOM 2389 H5 C B 74 14.180 14.209 -4.559 1.00 1.00 H +ATOM 2390 H6 C B 74 15.734 15.565 -5.886 1.00 1.00 H +ATOM 2391 P U B 75 15.709 20.248 -8.338 1.00 1.00 P +ATOM 2392 OP1 U B 75 16.522 21.426 -8.712 1.00 1.00 O +ATOM 2393 OP2 U B 75 15.255 20.081 -6.940 1.00 1.00 O +ATOM 2394 O5' U B 75 14.415 20.215 -9.302 1.00 1.00 O +ATOM 2395 C5' U B 75 14.567 19.925 -10.693 1.00 1.00 C +ATOM 2396 C4' U B 75 13.528 18.923 -11.204 1.00 1.00 C +ATOM 2397 O4' U B 75 13.585 17.714 -10.463 1.00 1.00 O +ATOM 2398 C3' U B 75 12.084 19.379 -11.115 1.00 1.00 C +ATOM 2399 O3' U B 75 11.745 20.123 -12.292 1.00 1.00 O +ATOM 2400 C2' U B 75 11.312 18.071 -11.112 1.00 1.00 C +ATOM 2401 O2' U B 75 10.797 17.758 -12.412 1.00 1.00 O +ATOM 2402 C1' U B 75 12.335 17.035 -10.644 1.00 1.00 C +ATOM 2403 N1 U B 75 11.956 16.330 -9.395 1.00 1.00 N +ATOM 2404 C2 U B 75 11.329 15.108 -9.546 1.00 1.00 C +ATOM 2405 O2 U B 75 11.087 14.628 -10.651 1.00 1.00 O +ATOM 2406 N3 U B 75 10.984 14.453 -8.376 1.00 1.00 N +ATOM 2407 C4 U B 75 11.211 14.909 -7.088 1.00 1.00 C +ATOM 2408 O4 U B 75 10.863 14.239 -6.117 1.00 1.00 O +ATOM 2409 C5 U B 75 11.871 16.194 -7.026 1.00 1.00 C +ATOM 2410 C6 U B 75 12.218 16.854 -8.158 1.00 1.00 C +ATOM 2411 H5' U B 75 15.564 19.514 -10.860 1.00 1.00 H +ATOM 2412 H5'' U B 75 14.469 20.852 -11.258 1.00 1.00 H +ATOM 2413 H4' U B 75 13.754 18.693 -12.243 1.00 1.00 H +ATOM 2414 H3' U B 75 11.900 19.953 -10.206 1.00 1.00 H +ATOM 2415 H2' U B 75 10.511 18.140 -10.380 1.00 1.00 H +ATOM 2416 HO2' U B 75 11.077 16.865 -12.623 1.00 1.00 H +ATOM 2417 H1' U B 75 12.463 16.300 -11.442 1.00 1.00 H +ATOM 2418 H3 U B 75 10.526 13.558 -8.471 1.00 1.00 H +ATOM 2419 H5 U B 75 12.093 16.637 -6.055 1.00 1.00 H +ATOM 2420 H6 U B 75 12.713 17.821 -8.082 1.00 1.00 H +ATOM 2421 P U B 76 10.390 20.993 -12.372 1.00 1.00 P +ATOM 2422 OP1 U B 76 10.456 21.831 -13.592 1.00 1.00 O +ATOM 2423 OP2 U B 76 10.169 21.630 -11.056 1.00 1.00 O +ATOM 2424 O5' U B 76 9.243 19.876 -12.591 1.00 1.00 O +ATOM 2425 C5' U B 76 9.164 19.124 -13.812 1.00 1.00 C +ATOM 2426 C4' U B 76 7.810 18.422 -13.960 1.00 1.00 C +ATOM 2427 O4' U B 76 7.840 17.146 -13.319 1.00 1.00 O +ATOM 2428 C3' U B 76 6.650 19.195 -13.356 1.00 1.00 C +ATOM 2429 O3' U B 76 6.014 19.976 -14.369 1.00 1.00 O +ATOM 2430 C2' U B 76 5.690 18.120 -12.868 1.00 1.00 C +ATOM 2431 O2' U B 76 4.650 17.879 -13.823 1.00 1.00 O +ATOM 2432 C1' U B 76 6.574 16.888 -12.686 1.00 1.00 C +ATOM 2433 N1 U B 76 6.847 16.560 -11.277 1.00 1.00 N +ATOM 2434 C2 U B 76 5.820 16.023 -10.523 1.00 1.00 C +ATOM 2435 O2 U B 76 4.705 15.810 -10.996 1.00 1.00 O +ATOM 2436 N3 U B 76 6.119 15.740 -9.203 1.00 1.00 N +ATOM 2437 C4 U B 76 7.339 15.943 -8.580 1.00 1.00 C +ATOM 2438 O4 U B 76 7.494 15.653 -7.395 1.00 1.00 O +ATOM 2439 C5 U B 76 8.354 16.506 -9.442 1.00 1.00 C +ATOM 2440 C6 U B 76 8.084 16.792 -10.739 1.00 1.00 C +ATOM 2441 H5' U B 76 9.955 18.376 -13.819 1.00 1.00 H +ATOM 2442 H5'' U B 76 9.307 19.800 -14.656 1.00 1.00 H +ATOM 2443 H4' U B 76 7.613 18.266 -15.020 1.00 1.00 H +ATOM 2444 H3' U B 76 6.987 19.819 -12.528 1.00 1.00 H +ATOM 2445 H2' U B 76 5.265 18.414 -11.906 1.00 1.00 H +ATOM 2446 HO2' U B 76 4.979 17.225 -14.446 1.00 1.00 H +ATOM 2447 H1' U B 76 6.101 16.033 -13.164 1.00 1.00 H +ATOM 2448 H3 U B 76 5.378 15.348 -8.640 1.00 1.00 H +ATOM 2449 H5 U B 76 9.349 16.703 -9.045 1.00 1.00 H +ATOM 2450 H6 U B 76 8.868 17.215 -11.367 1.00 1.00 H +ATOM 2451 P C B 77 4.902 21.066 -13.969 1.00 1.00 P +ATOM 2452 OP1 C B 77 4.449 21.740 -15.207 1.00 1.00 O +ATOM 2453 OP2 C B 77 5.424 21.867 -12.840 1.00 1.00 O +ATOM 2454 O5' C B 77 3.697 20.146 -13.425 1.00 1.00 O +ATOM 2455 C5' C B 77 2.974 20.516 -12.247 1.00 1.00 C +ATOM 2456 C4' C B 77 2.075 19.382 -11.757 1.00 1.00 C +ATOM 2457 O4' C B 77 2.873 18.291 -11.301 1.00 1.00 O +ATOM 2458 C3' C B 77 1.163 19.774 -10.606 1.00 1.00 C +ATOM 2459 O3' C B 77 -0.112 20.174 -11.119 1.00 1.00 O +ATOM 2460 C2' C B 77 1.010 18.491 -9.800 1.00 1.00 C +ATOM 2461 O2' C B 77 -0.187 17.791 -10.160 1.00 1.00 O +ATOM 2462 C1' C B 77 2.255 17.683 -10.157 1.00 1.00 C +ATOM 2463 N1 C B 77 3.266 17.642 -9.086 1.00 1.00 N +ATOM 2464 C2 C B 77 3.095 16.712 -8.072 1.00 1.00 C +ATOM 2465 O2 C B 77 2.123 15.961 -8.082 1.00 1.00 O +ATOM 2466 N3 C B 77 4.026 16.661 -7.079 1.00 1.00 N +ATOM 2467 C4 C B 77 5.080 17.488 -7.082 1.00 1.00 C +ATOM 2468 N4 C B 77 5.974 17.410 -6.097 1.00 1.00 N +ATOM 2469 C5 C B 77 5.259 18.450 -8.125 1.00 1.00 C +ATOM 2470 C6 C B 77 4.333 18.492 -9.103 1.00 1.00 C +ATOM 2471 H5' C B 77 2.357 21.388 -12.469 1.00 1.00 H +ATOM 2472 H5'' C B 77 3.684 20.774 -11.461 1.00 1.00 H +ATOM 2473 H4' C B 77 1.464 19.036 -12.587 1.00 1.00 H +ATOM 2474 H3' C B 77 1.613 20.563 -10.001 1.00 1.00 H +ATOM 2475 H2' C B 77 1.012 18.723 -8.731 1.00 1.00 H +ATOM 2476 HO2' C B 77 -0.505 17.345 -9.371 1.00 1.00 H +ATOM 2477 H1' C B 77 1.963 16.663 -10.407 1.00 1.00 H +ATOM 2478 H41 C B 77 5.851 16.732 -5.358 1.00 1.00 H +ATOM 2479 H42 C B 77 6.773 18.028 -6.088 1.00 1.00 H +ATOM 2480 H5 C B 77 6.116 19.125 -8.129 1.00 1.00 H +ATOM 2481 H6 C B 77 4.437 19.212 -9.915 1.00 1.00 H +ATOM 2482 P C B 78 -0.941 21.361 -10.416 1.00 1.00 P +ATOM 2483 OP1 C B 78 -2.337 21.301 -10.905 1.00 1.00 O +ATOM 2484 OP2 C B 78 -0.164 22.613 -10.550 1.00 1.00 O +ATOM 2485 O5' C B 78 -0.932 20.920 -8.869 1.00 1.00 O +ATOM 2486 C5' C B 78 -1.214 21.868 -7.836 1.00 1.00 C +ATOM 2487 C4' C B 78 -2.138 21.271 -6.775 1.00 1.00 C +ATOM 2488 O4' C B 78 -1.794 19.902 -6.551 1.00 1.00 O +ATOM 2489 C3' C B 78 -2.084 21.977 -5.426 1.00 1.00 C +ATOM 2490 O3' C B 78 -3.154 22.925 -5.340 1.00 1.00 O +ATOM 2491 C2' C B 78 -2.305 20.856 -4.425 1.00 1.00 C +ATOM 2492 O2' C B 78 -3.693 20.695 -4.113 1.00 1.00 O +ATOM 2493 C1' C B 78 -1.750 19.635 -5.142 1.00 1.00 C +ATOM 2494 N1 C B 78 -0.352 19.321 -4.797 1.00 1.00 N +ATOM 2495 C2 C B 78 -0.112 18.677 -3.595 1.00 1.00 C +ATOM 2496 O2 C B 78 -1.048 18.405 -2.845 1.00 1.00 O +ATOM 2497 N3 C B 78 1.173 18.361 -3.277 1.00 1.00 N +ATOM 2498 C4 C B 78 2.182 18.666 -4.105 1.00 1.00 C +ATOM 2499 N4 C B 78 3.429 18.342 -3.763 1.00 1.00 N +ATOM 2500 C5 C B 78 1.939 19.332 -5.347 1.00 1.00 C +ATOM 2501 C6 C B 78 0.664 19.640 -5.652 1.00 1.00 C +ATOM 2502 H5' C B 78 -1.695 22.742 -8.276 1.00 1.00 H +ATOM 2503 H5'' C B 78 -0.279 22.174 -7.368 1.00 1.00 H +ATOM 2504 H4' C B 78 -3.160 21.309 -7.145 1.00 1.00 H +ATOM 2505 H3' C B 78 -1.115 22.455 -5.271 1.00 1.00 H +ATOM 2506 H2' C B 78 -1.726 21.044 -3.523 1.00 1.00 H +ATOM 2507 HO2' C B 78 -4.181 20.750 -4.938 1.00 1.00 H +ATOM 2508 H1' C B 78 -2.376 18.772 -4.919 1.00 1.00 H +ATOM 2509 H41 C B 78 3.606 17.872 -2.889 1.00 1.00 H +ATOM 2510 H42 C B 78 4.196 18.567 -4.380 1.00 1.00 H +ATOM 2511 H5 C B 78 2.756 19.581 -6.023 1.00 1.00 H +ATOM 2512 H6 C B 78 0.440 20.148 -6.591 1.00 1.00 H +ATOM 2513 P U B 79 -3.029 24.234 -4.408 1.00 1.00 P +ATOM 2514 OP1 U B 79 -4.245 25.053 -4.596 1.00 1.00 O +ATOM 2515 OP2 U B 79 -1.693 24.834 -4.624 1.00 1.00 O +ATOM 2516 O5' U B 79 -3.068 23.611 -2.924 1.00 1.00 O +ATOM 2517 C5' U B 79 -4.144 22.761 -2.524 1.00 1.00 C +ATOM 2518 C4' U B 79 -3.860 22.094 -1.181 1.00 1.00 C +ATOM 2519 O4' U B 79 -2.593 21.450 -1.218 1.00 1.00 O +ATOM 2520 C3' U B 79 -3.814 23.053 -0.005 1.00 1.00 C +ATOM 2521 O3' U B 79 -5.122 23.175 0.569 1.00 1.00 O +ATOM 2522 C2' U B 79 -2.877 22.367 0.980 1.00 1.00 C +ATOM 2523 O2' U B 79 -3.606 21.681 2.003 1.00 1.00 O +ATOM 2524 C1' U B 79 -2.077 21.388 0.115 1.00 1.00 C +ATOM 2525 N1 U B 79 -0.633 21.677 0.062 1.00 1.00 N +ATOM 2526 C2 U B 79 0.079 21.500 1.232 1.00 1.00 C +ATOM 2527 O2 U B 79 -0.459 21.142 2.277 1.00 1.00 O +ATOM 2528 N3 U B 79 1.438 21.750 1.159 1.00 1.00 N +ATOM 2529 C4 U B 79 2.135 22.157 0.035 1.00 1.00 C +ATOM 2530 O4 U B 79 3.348 22.350 0.085 1.00 1.00 O +ATOM 2531 C5 U B 79 1.311 22.317 -1.143 1.00 1.00 C +ATOM 2532 C6 U B 79 -0.022 22.077 -1.096 1.00 1.00 C +ATOM 2533 H5' U B 79 -4.292 21.991 -3.279 1.00 1.00 H +ATOM 2534 H5'' U B 79 -5.055 23.353 -2.440 1.00 1.00 H +ATOM 2535 H4' U B 79 -4.623 21.340 -0.995 1.00 1.00 H +ATOM 2536 H3' U B 79 -3.418 24.023 -0.308 1.00 1.00 H +ATOM 2537 H2' U B 79 -2.201 23.105 1.423 1.00 1.00 H +ATOM 2538 HO2' U B 79 -3.095 21.757 2.814 1.00 1.00 H +ATOM 2539 H1' U B 79 -2.219 20.376 0.500 1.00 1.00 H +ATOM 2540 H3 U B 79 1.971 21.625 2.007 1.00 1.00 H +ATOM 2541 H5 U B 79 1.767 22.635 -2.079 1.00 1.00 H +ATOM 2542 H6 U B 79 -0.620 22.207 -1.998 1.00 1.00 H +ATOM 2543 P A B 80 -5.537 24.485 1.413 1.00 1.00 P +ATOM 2544 OP1 A B 80 -6.976 24.380 1.748 1.00 1.00 O +ATOM 2545 OP2 A B 80 -5.033 25.679 0.699 1.00 1.00 O +ATOM 2546 O5' A B 80 -4.694 24.318 2.775 1.00 1.00 O +ATOM 2547 C5' A B 80 -4.955 23.223 3.657 1.00 1.00 C +ATOM 2548 C4' A B 80 -4.048 23.252 4.885 1.00 1.00 C +ATOM 2549 O4' A B 80 -2.688 23.053 4.472 1.00 1.00 O +ATOM 2550 C3' A B 80 -4.108 24.563 5.672 1.00 1.00 C +ATOM 2551 O3' A B 80 -4.176 24.277 7.074 1.00 1.00 O +ATOM 2552 C2' A B 80 -2.788 25.253 5.365 1.00 1.00 C +ATOM 2553 O2' A B 80 -2.296 25.966 6.504 1.00 1.00 O +ATOM 2554 C1' A B 80 -1.869 24.101 4.998 1.00 1.00 C +ATOM 2555 N9 A B 80 -0.848 24.440 3.987 1.00 1.00 N +ATOM 2556 C8 A B 80 -0.991 25.145 2.819 1.00 1.00 C +ATOM 2557 N7 A B 80 0.120 25.294 2.154 1.00 1.00 N +ATOM 2558 C5 A B 80 1.067 24.641 2.936 1.00 1.00 C +ATOM 2559 C6 A B 80 2.449 24.436 2.781 1.00 1.00 C +ATOM 2560 N6 A B 80 3.141 24.892 1.734 1.00 1.00 N +ATOM 2561 N1 A B 80 3.082 23.747 3.744 1.00 1.00 N +ATOM 2562 C2 A B 80 2.388 23.296 4.781 1.00 1.00 C +ATOM 2563 N3 A B 80 1.093 23.422 5.040 1.00 1.00 N +ATOM 2564 C4 A B 80 0.486 24.118 4.055 1.00 1.00 C +ATOM 2565 H5' A B 80 -4.798 22.289 3.120 1.00 1.00 H +ATOM 2566 H5'' A B 80 -5.994 23.271 3.983 1.00 1.00 H +ATOM 2567 H4' A B 80 -4.327 22.433 5.547 1.00 1.00 H +ATOM 2568 H3' A B 80 -4.951 25.175 5.350 1.00 1.00 H +ATOM 2569 H2' A B 80 -2.907 25.923 4.510 1.00 1.00 H +ATOM 2570 HO2' A B 80 -2.018 25.314 7.151 1.00 1.00 H +ATOM 2571 H1' A B 80 -1.370 23.742 5.900 1.00 1.00 H +ATOM 2572 H8 A B 80 -1.946 25.545 2.479 1.00 1.00 H +ATOM 2573 H61 A B 80 4.135 24.717 1.671 1.00 1.00 H +ATOM 2574 H62 A B 80 2.673 25.411 1.006 1.00 1.00 H +ATOM 2575 H2 A B 80 2.963 22.744 5.526 1.00 1.00 H +ATOM 2576 P A B 81 -4.771 25.366 8.102 1.00 1.00 P +ATOM 2577 OP1 A B 81 -6.247 25.332 8.007 1.00 1.00 O +ATOM 2578 OP2 A B 81 -4.046 26.640 7.897 1.00 1.00 O +ATOM 2579 O5' A B 81 -4.344 24.770 9.535 1.00 1.00 O +ATOM 2580 C5' A B 81 -5.330 24.231 10.421 1.00 1.00 C +ATOM 2581 C4' A B 81 -4.769 23.067 11.234 1.00 1.00 C +ATOM 2582 O4' A B 81 -4.451 21.982 10.361 1.00 1.00 O +ATOM 2583 C3' A B 81 -3.505 23.408 12.014 1.00 1.00 C +ATOM 2584 O3' A B 81 -3.853 23.769 13.359 1.00 1.00 O +ATOM 2585 C2' A B 81 -2.715 22.107 12.007 1.00 1.00 C +ATOM 2586 O2' A B 81 -2.991 21.322 13.172 1.00 1.00 O +ATOM 2587 C1' A B 81 -3.195 21.406 10.740 1.00 1.00 C +ATOM 2588 N9 A B 81 -2.275 21.546 9.594 1.00 1.00 N +ATOM 2589 C8 A B 81 -2.436 22.274 8.444 1.00 1.00 C +ATOM 2590 N7 A B 81 -1.434 22.177 7.614 1.00 1.00 N +ATOM 2591 C5 A B 81 -0.547 21.323 8.262 1.00 1.00 C +ATOM 2592 C6 A B 81 0.715 20.817 7.907 1.00 1.00 C +ATOM 2593 N6 A B 81 1.325 21.118 6.759 1.00 1.00 N +ATOM 2594 N1 A B 81 1.318 19.994 8.781 1.00 1.00 N +ATOM 2595 C2 A B 81 0.706 19.701 9.922 1.00 1.00 C +ATOM 2596 N3 A B 81 -0.472 20.110 10.368 1.00 1.00 N +ATOM 2597 C4 A B 81 -1.052 20.933 9.469 1.00 1.00 C +ATOM 2598 H5' A B 81 -6.181 23.880 9.837 1.00 1.00 H +ATOM 2599 H5'' A B 81 -5.664 25.015 11.103 1.00 1.00 H +ATOM 2600 H4' A B 81 -5.532 22.730 11.935 1.00 1.00 H +ATOM 2601 H3' A B 81 -2.946 24.205 11.520 1.00 1.00 H +ATOM 2602 H2' A B 81 -1.648 22.320 11.929 1.00 1.00 H +ATOM 2603 HO2' A B 81 -3.735 21.728 13.621 1.00 1.00 H +ATOM 2604 H1' A B 81 -3.338 20.347 10.952 1.00 1.00 H +ATOM 2605 H8 A B 81 -3.320 22.877 8.240 1.00 1.00 H +ATOM 2606 H61 A B 81 2.233 20.727 6.552 1.00 1.00 H +ATOM 2607 H62 A B 81 0.879 21.736 6.096 1.00 1.00 H +ATOM 2608 H2 A B 81 1.250 19.026 10.584 1.00 1.00 H +ATOM 2609 P G B 82 -2.943 24.795 14.209 1.00 1.00 P +ATOM 2610 OP1 G B 82 -3.678 25.146 15.445 1.00 1.00 O +ATOM 2611 OP2 G B 82 -2.484 25.867 13.299 1.00 1.00 O +ATOM 2612 O5' G B 82 -1.662 23.905 14.620 1.00 1.00 O +ATOM 2613 C5' G B 82 -1.789 22.842 15.571 1.00 1.00 C +ATOM 2614 C4' G B 82 -0.602 21.875 15.510 1.00 1.00 C +ATOM 2615 O4' G B 82 -0.406 21.444 14.161 1.00 1.00 O +ATOM 2616 C3' G B 82 0.721 22.467 15.996 1.00 1.00 C +ATOM 2617 O3' G B 82 0.959 22.066 17.352 1.00 1.00 O +ATOM 2618 C2' G B 82 1.753 21.826 15.078 1.00 1.00 C +ATOM 2619 O2' G B 82 2.241 20.592 15.614 1.00 1.00 O +ATOM 2620 C1' G B 82 0.972 21.598 13.796 1.00 1.00 C +ATOM 2621 N9 G B 82 1.052 22.717 12.840 1.00 1.00 N +ATOM 2622 C8 G B 82 0.256 23.831 12.757 1.00 1.00 C +ATOM 2623 N7 G B 82 0.577 24.638 11.786 1.00 1.00 N +ATOM 2624 C5 G B 82 1.664 24.017 11.178 1.00 1.00 C +ATOM 2625 C6 G B 82 2.440 24.429 10.060 1.00 1.00 C +ATOM 2626 O6 G B 82 2.316 25.443 9.375 1.00 1.00 O +ATOM 2627 N1 G B 82 3.443 23.514 9.771 1.00 1.00 N +ATOM 2628 C2 G B 82 3.674 22.347 10.469 1.00 1.00 C +ATOM 2629 N2 G B 82 4.687 21.594 10.040 1.00 1.00 N +ATOM 2630 N3 G B 82 2.946 21.959 11.521 1.00 1.00 N +ATOM 2631 C4 G B 82 1.962 22.839 11.817 1.00 1.00 C +ATOM 2632 H5' G B 82 -2.707 22.291 15.363 1.00 1.00 H +ATOM 2633 H5'' G B 82 -1.852 23.268 16.572 1.00 1.00 H +ATOM 2634 H4' G B 82 -0.836 21.001 16.116 1.00 1.00 H +ATOM 2635 H3' G B 82 0.726 23.554 15.892 1.00 1.00 H +ATOM 2636 H2' G B 82 2.574 22.519 14.892 1.00 1.00 H +ATOM 2637 HO2' G B 82 3.036 20.363 15.125 1.00 1.00 H +ATOM 2638 H1' G B 82 1.325 20.688 13.314 1.00 1.00 H +ATOM 2639 H8 G B 82 -0.571 24.022 13.441 1.00 1.00 H +ATOM 2640 H1 G B 82 4.038 23.738 8.986 1.00 1.00 H +ATOM 2641 H21 G B 82 5.235 21.890 9.245 1.00 1.00 H +ATOM 2642 H22 G B 82 4.906 20.728 10.510 1.00 1.00 H +ATOM 2643 P U B 83 1.623 23.085 18.414 1.00 1.00 P +ATOM 2644 OP1 U B 83 1.593 22.443 19.749 1.00 1.00 O +ATOM 2645 OP2 U B 83 1.008 24.417 18.225 1.00 1.00 O +ATOM 2646 O5' U B 83 3.158 23.167 17.934 1.00 1.00 O +ATOM 2647 C5' U B 83 4.023 22.037 18.070 1.00 1.00 C +ATOM 2648 C4' U B 83 5.330 22.236 17.308 1.00 1.00 C +ATOM 2649 O4' U B 83 5.058 22.320 15.910 1.00 1.00 O +ATOM 2650 C3' U B 83 6.091 23.499 17.686 1.00 1.00 C +ATOM 2651 O3' U B 83 7.038 23.197 18.720 1.00 1.00 O +ATOM 2652 C2' U B 83 6.818 23.855 16.400 1.00 1.00 C +ATOM 2653 O2' U B 83 8.094 23.212 16.331 1.00 1.00 O +ATOM 2654 C1' U B 83 5.872 23.341 15.317 1.00 1.00 C +ATOM 2655 N1 U B 83 4.960 24.370 14.776 1.00 1.00 N +ATOM 2656 C2 U B 83 5.324 24.983 13.591 1.00 1.00 C +ATOM 2657 O2 U B 83 6.371 24.709 13.007 1.00 1.00 O +ATOM 2658 N3 U B 83 4.440 25.927 13.099 1.00 1.00 N +ATOM 2659 C4 U B 83 3.243 26.306 13.681 1.00 1.00 C +ATOM 2660 O4 U B 83 2.532 27.159 13.152 1.00 1.00 O +ATOM 2661 C5 U B 83 2.943 25.615 14.915 1.00 1.00 C +ATOM 2662 C6 U B 83 3.793 24.686 15.416 1.00 1.00 C +ATOM 2663 H5' U B 83 3.515 21.154 17.682 1.00 1.00 H +ATOM 2664 H5'' U B 83 4.245 21.885 19.127 1.00 1.00 H +ATOM 2665 H4' U B 83 5.970 21.374 17.480 1.00 1.00 H +ATOM 2666 H3' U B 83 5.407 24.295 17.985 1.00 1.00 H +ATOM 2667 H2' U B 83 6.924 24.936 16.317 1.00 1.00 H +ATOM 2668 HO2' U B 83 8.532 23.358 17.173 1.00 1.00 H +ATOM 2669 H1' U B 83 6.456 22.908 14.502 1.00 1.00 H +ATOM 2670 H3 U B 83 4.693 26.383 12.233 1.00 1.00 H +ATOM 2671 H5 U B 83 2.022 25.844 15.449 1.00 1.00 H +ATOM 2672 H6 U B 83 3.542 24.180 16.348 1.00 1.00 H +ATOM 2673 P C B 84 7.362 24.259 19.891 1.00 1.00 P +ATOM 2674 OP1 C B 84 8.239 23.597 20.881 1.00 1.00 O +ATOM 2675 OP2 C B 84 6.086 24.868 20.329 1.00 1.00 O +ATOM 2676 O5' C B 84 8.223 25.389 19.133 1.00 1.00 O +ATOM 2677 C5' C B 84 9.620 25.201 18.893 1.00 1.00 C +ATOM 2678 C4' C B 84 10.162 26.222 17.893 1.00 1.00 C +ATOM 2679 O4' C B 84 9.356 26.219 16.718 1.00 1.00 O +ATOM 2680 C3' C B 84 10.174 27.658 18.400 1.00 1.00 C +ATOM 2681 O3' C B 84 11.423 27.945 19.044 1.00 1.00 O +ATOM 2682 C2' C B 84 10.049 28.477 17.126 1.00 1.00 C +ATOM 2683 O2' C B 84 11.335 28.837 16.609 1.00 1.00 O +ATOM 2684 C1' C B 84 9.307 27.545 16.171 1.00 1.00 C +ATOM 2685 N1 C B 84 7.884 27.898 15.979 1.00 1.00 N +ATOM 2686 C2 C B 84 7.566 28.698 14.893 1.00 1.00 C +ATOM 2687 O2 C B 84 8.454 29.103 14.146 1.00 1.00 O +ATOM 2688 N3 C B 84 6.258 29.018 14.687 1.00 1.00 N +ATOM 2689 C4 C B 84 5.303 28.570 15.512 1.00 1.00 C +ATOM 2690 N4 C B 84 4.031 28.900 15.282 1.00 1.00 N +ATOM 2691 C5 C B 84 5.626 27.744 16.634 1.00 1.00 C +ATOM 2692 C6 C B 84 6.923 27.433 16.830 1.00 1.00 C +ATOM 2693 H5' C B 84 9.780 24.198 18.497 1.00 1.00 H +ATOM 2694 H5'' C B 84 10.161 25.302 19.835 1.00 1.00 H +ATOM 2695 H4' C B 84 11.175 25.938 17.615 1.00 1.00 H +ATOM 2696 H3' C B 84 9.330 27.843 19.067 1.00 1.00 H +ATOM 2697 H2' C B 84 9.447 29.364 17.313 1.00 1.00 H +ATOM 2698 HO2' C B 84 11.990 28.341 17.106 1.00 1.00 H +ATOM 2699 H1' C B 84 9.811 27.549 15.205 1.00 1.00 H +ATOM 2700 H41 C B 84 3.796 29.484 14.491 1.00 1.00 H +ATOM 2701 H42 C B 84 3.304 28.568 15.897 1.00 1.00 H +ATOM 2702 H5 C B 84 4.851 27.377 17.307 1.00 1.00 H +ATOM 2703 H6 C B 84 7.207 26.807 17.674 1.00 1.00 H +ATOM 2704 P C B 85 11.526 29.110 20.157 1.00 1.00 P +ATOM 2705 OP1 C B 85 12.888 29.077 20.735 1.00 1.00 O +ATOM 2706 OP2 C B 85 10.347 29.003 21.046 1.00 1.00 O +ATOM 2707 O5' C B 85 11.380 30.465 19.290 1.00 1.00 O +ATOM 2708 C5' C B 85 12.438 30.900 18.429 1.00 1.00 C +ATOM 2709 C4' C B 85 11.990 32.032 17.502 1.00 1.00 C +ATOM 2710 O4' C B 85 10.859 31.621 16.748 1.00 1.00 O +ATOM 2711 C3' C B 85 11.574 33.311 18.208 1.00 1.00 C +ATOM 2712 O3' C B 85 12.711 34.157 18.407 1.00 1.00 O +ATOM 2713 C2' C B 85 10.617 33.958 17.221 1.00 1.00 C +ATOM 2714 O2' C B 85 11.296 34.893 16.374 1.00 1.00 O +ATOM 2715 C1' C B 85 10.070 32.773 16.423 1.00 1.00 C +ATOM 2716 N1 C B 85 8.663 32.447 16.735 1.00 1.00 N +ATOM 2717 C2 C B 85 7.683 32.964 15.903 1.00 1.00 C +ATOM 2718 O2 C B 85 7.996 33.677 14.952 1.00 1.00 O +ATOM 2719 N3 C B 85 6.383 32.663 16.173 1.00 1.00 N +ATOM 2720 C4 C B 85 6.059 31.886 17.216 1.00 1.00 C +ATOM 2721 N4 C B 85 4.776 31.611 17.454 1.00 1.00 N +ATOM 2722 C5 C B 85 7.067 31.350 18.075 1.00 1.00 C +ATOM 2723 C6 C B 85 8.350 31.654 17.800 1.00 1.00 C +ATOM 2724 H5' C B 85 12.775 30.058 17.825 1.00 1.00 H +ATOM 2725 H5'' C B 85 13.270 31.253 19.040 1.00 1.00 H +ATOM 2726 H4' C B 85 12.797 32.257 16.808 1.00 1.00 H +ATOM 2727 H3' C B 85 11.071 33.091 19.151 1.00 1.00 H +ATOM 2728 H2' C B 85 9.806 34.446 17.760 1.00 1.00 H +ATOM 2729 HO2' C B 85 11.258 34.549 15.480 1.00 1.00 H +ATOM 2730 H1' C B 85 10.166 32.984 15.357 1.00 1.00 H +ATOM 2731 H41 C B 85 4.062 31.985 16.851 1.00 1.00 H +ATOM 2732 H42 C B 85 4.522 31.026 18.236 1.00 1.00 H +ATOM 2733 H5 C B 85 6.808 30.718 18.925 1.00 1.00 H +ATOM 2734 H6 C B 85 9.147 31.262 18.434 1.00 1.00 H +ATOM 2735 P U B 86 12.696 35.282 19.561 1.00 1.00 P +ATOM 2736 OP1 U B 86 13.967 36.037 19.485 1.00 1.00 O +ATOM 2737 OP2 U B 86 12.298 34.637 20.831 1.00 1.00 O +ATOM 2738 O5' U B 86 11.502 36.262 19.094 1.00 1.00 O +ATOM 2739 C5' U B 86 11.644 37.064 17.918 1.00 1.00 C +ATOM 2740 C4' U B 86 10.343 37.777 17.539 1.00 1.00 C +ATOM 2741 O4' U B 86 9.300 36.831 17.362 1.00 1.00 O +ATOM 2742 C3' U B 86 9.844 38.777 18.576 1.00 1.00 C +ATOM 2743 O3' U B 86 10.301 40.101 18.279 1.00 1.00 O +ATOM 2744 C2' U B 86 8.316 38.685 18.475 1.00 1.00 C +ATOM 2745 O2' U B 86 7.757 39.903 17.966 1.00 1.00 O +ATOM 2746 C1' U B 86 8.062 37.519 17.523 1.00 1.00 C +ATOM 2747 N1 U B 86 7.060 36.551 18.021 1.00 1.00 N +ATOM 2748 C2 U B 86 5.760 36.693 17.578 1.00 1.00 C +ATOM 2749 O2 U B 86 5.430 37.580 16.793 1.00 1.00 O +ATOM 2750 N3 U B 86 4.846 35.779 18.070 1.00 1.00 N +ATOM 2751 C4 U B 86 5.118 34.750 18.955 1.00 1.00 C +ATOM 2752 O4 U B 86 4.225 33.991 19.327 1.00 1.00 O +ATOM 2753 C5 U B 86 6.501 34.677 19.367 1.00 1.00 C +ATOM 2754 C6 U B 86 7.415 35.562 18.897 1.00 1.00 C +ATOM 2755 H5' U B 86 11.954 36.426 17.091 1.00 1.00 H +ATOM 2756 H5'' U B 86 12.417 37.812 18.095 1.00 1.00 H +ATOM 2757 H4' U B 86 10.495 38.299 16.595 1.00 1.00 H +ATOM 2758 H3' U B 86 10.169 38.470 19.573 1.00 1.00 H +ATOM 2759 HO3' U B 86 10.988 40.313 18.914 1.00 1.00 H +ATOM 2760 H2' U B 86 7.893 38.453 19.456 1.00 1.00 H +ATOM 2761 HO2' U B 86 7.995 39.961 17.038 1.00 1.00 H +ATOM 2762 H1' U B 86 7.742 37.909 16.556 1.00 1.00 H +ATOM 2763 H3 U B 86 3.891 35.871 17.755 1.00 1.00 H +ATOM 2764 H5 U B 86 6.815 33.902 20.066 1.00 1.00 H +ATOM 2765 H6 U B 86 8.451 35.485 19.225 1.00 1.00 H +TER 2766 U B 86 +ENDMDL +MODEL 3 +ATOM 1 O5' G A 1 3.482 -43.085 6.389 1.00 1.00 O +ATOM 2 C5' G A 1 4.118 -43.927 5.425 1.00 1.00 C +ATOM 3 C4' G A 1 3.154 -44.323 4.308 1.00 1.00 C +ATOM 4 O4' G A 1 2.106 -45.139 4.839 1.00 1.00 O +ATOM 5 C3' G A 1 2.497 -43.138 3.609 1.00 1.00 C +ATOM 6 O3' G A 1 3.191 -42.848 2.392 1.00 1.00 O +ATOM 7 C2' G A 1 1.097 -43.630 3.296 1.00 1.00 C +ATOM 8 O2' G A 1 1.031 -44.234 2.000 1.00 1.00 O +ATOM 9 C1' G A 1 0.837 -44.646 4.395 1.00 1.00 C +ATOM 10 N9 G A 1 0.151 -44.083 5.565 1.00 1.00 N +ATOM 11 C8 G A 1 0.649 -43.871 6.824 1.00 1.00 C +ATOM 12 N7 G A 1 -0.214 -43.359 7.655 1.00 1.00 N +ATOM 13 C5 G A 1 -1.371 -43.222 6.895 1.00 1.00 C +ATOM 14 C6 G A 1 -2.650 -42.717 7.263 1.00 1.00 C +ATOM 15 O6 G A 1 -3.013 -42.282 8.353 1.00 1.00 O +ATOM 16 N1 G A 1 -3.538 -42.753 6.195 1.00 1.00 N +ATOM 17 C2 G A 1 -3.237 -43.217 4.932 1.00 1.00 C +ATOM 18 N2 G A 1 -4.224 -43.174 4.036 1.00 1.00 N +ATOM 19 N3 G A 1 -2.036 -43.692 4.584 1.00 1.00 N +ATOM 20 C4 G A 1 -1.157 -43.663 5.613 1.00 1.00 C +ATOM 21 H5' G A 1 4.488 -44.824 5.926 1.00 1.00 H +ATOM 22 H5'' G A 1 4.961 -43.397 4.988 1.00 1.00 H +ATOM 23 H4' G A 1 3.699 -44.906 3.567 1.00 1.00 H +ATOM 24 H3' G A 1 2.467 -42.267 4.266 1.00 1.00 H +ATOM 25 H2' G A 1 0.384 -42.806 3.376 1.00 1.00 H +ATOM 26 HO2' G A 1 0.104 -44.356 1.789 1.00 1.00 H +ATOM 27 H1' G A 1 0.247 -45.470 3.995 1.00 1.00 H +ATOM 28 H8 G A 1 1.676 -44.108 7.105 1.00 1.00 H +ATOM 29 H1 G A 1 -4.469 -42.409 6.381 1.00 1.00 H +ATOM 30 H21 G A 1 -5.130 -42.815 4.300 1.00 1.00 H +ATOM 31 H22 G A 1 -4.065 -43.499 3.093 1.00 1.00 H +ATOM 32 HO5' G A 1 3.410 -42.210 6.002 1.00 1.00 H +ATOM 33 P G A 2 3.154 -41.367 1.760 1.00 1.00 P +ATOM 34 OP1 G A 2 3.822 -41.410 0.440 1.00 1.00 O +ATOM 35 OP2 G A 2 3.622 -40.415 2.792 1.00 1.00 O +ATOM 36 O5' G A 2 1.580 -41.119 1.524 1.00 1.00 O +ATOM 37 C5' G A 2 0.845 -41.899 0.575 1.00 1.00 C +ATOM 38 C4' G A 2 -0.628 -41.503 0.554 1.00 1.00 C +ATOM 39 O4' G A 2 -1.229 -41.761 1.822 1.00 1.00 O +ATOM 40 C3' G A 2 -0.875 -40.032 0.260 1.00 1.00 C +ATOM 41 O3' G A 2 -0.989 -39.844 -1.156 1.00 1.00 O +ATOM 42 C2' G A 2 -2.210 -39.754 0.937 1.00 1.00 C +ATOM 43 O2' G A 2 -3.295 -39.856 0.008 1.00 1.00 O +ATOM 44 C1' G A 2 -2.302 -40.830 2.024 1.00 1.00 C +ATOM 45 N9 G A 2 -2.196 -40.306 3.395 1.00 1.00 N +ATOM 46 C8 G A 2 -1.112 -40.280 4.233 1.00 1.00 C +ATOM 47 N7 G A 2 -1.358 -39.756 5.401 1.00 1.00 N +ATOM 48 C5 G A 2 -2.705 -39.406 5.334 1.00 1.00 C +ATOM 49 C6 G A 2 -3.539 -38.793 6.311 1.00 1.00 C +ATOM 50 O6 G A 2 -3.244 -38.432 7.448 1.00 1.00 O +ATOM 51 N1 G A 2 -4.833 -38.617 5.838 1.00 1.00 N +ATOM 52 C2 G A 2 -5.273 -38.983 4.583 1.00 1.00 C +ATOM 53 N2 G A 2 -6.552 -38.734 4.309 1.00 1.00 N +ATOM 54 N3 G A 2 -4.492 -39.560 3.665 1.00 1.00 N +ATOM 55 C4 G A 2 -3.226 -39.740 4.109 1.00 1.00 C +ATOM 56 H5' G A 2 0.927 -42.952 0.835 1.00 1.00 H +ATOM 57 H5'' G A 2 1.269 -41.744 -0.417 1.00 1.00 H +ATOM 58 H4' G A 2 -1.142 -42.102 -0.195 1.00 1.00 H +ATOM 59 H3' G A 2 -0.083 -39.411 0.685 1.00 1.00 H +ATOM 60 H2' G A 2 -2.190 -38.764 1.399 1.00 1.00 H +ATOM 61 HO2' G A 2 -3.010 -40.439 -0.699 1.00 1.00 H +ATOM 62 H1' G A 2 -3.252 -41.356 1.926 1.00 1.00 H +ATOM 63 H8 G A 2 -0.131 -40.663 3.950 1.00 1.00 H +ATOM 64 H1 G A 2 -5.485 -38.186 6.477 1.00 1.00 H +ATOM 65 H21 G A 2 -7.140 -38.299 5.003 1.00 1.00 H +ATOM 66 H22 G A 2 -6.933 -38.978 3.408 1.00 1.00 H +ATOM 67 P G A 3 -0.480 -38.485 -1.857 1.00 1.00 P +ATOM 68 OP1 G A 3 -0.234 -38.770 -3.289 1.00 1.00 O +ATOM 69 OP2 G A 3 0.599 -37.910 -1.024 1.00 1.00 O +ATOM 70 O5' G A 3 -1.768 -37.524 -1.750 1.00 1.00 O +ATOM 71 C5' G A 3 -3.026 -37.928 -2.300 1.00 1.00 C +ATOM 72 C4' G A 3 -4.177 -37.118 -1.712 1.00 1.00 C +ATOM 73 O4' G A 3 -4.156 -37.214 -0.291 1.00 1.00 O +ATOM 74 C3' G A 3 -4.130 -35.636 -2.045 1.00 1.00 C +ATOM 75 O3' G A 3 -4.882 -35.378 -3.237 1.00 1.00 O +ATOM 76 C2' G A 3 -4.809 -34.976 -0.856 1.00 1.00 C +ATOM 77 O2' G A 3 -6.189 -34.706 -1.128 1.00 1.00 O +ATOM 78 C1' G A 3 -4.653 -35.995 0.272 1.00 1.00 C +ATOM 79 N9 G A 3 -3.717 -35.571 1.327 1.00 1.00 N +ATOM 80 C8 G A 3 -2.403 -35.920 1.509 1.00 1.00 C +ATOM 81 N7 G A 3 -1.856 -35.392 2.567 1.00 1.00 N +ATOM 82 C5 G A 3 -2.879 -34.635 3.130 1.00 1.00 C +ATOM 83 C6 G A 3 -2.877 -33.830 4.304 1.00 1.00 C +ATOM 84 O6 G A 3 -1.953 -33.628 5.088 1.00 1.00 O +ATOM 85 N1 G A 3 -4.114 -33.236 4.515 1.00 1.00 N +ATOM 86 C2 G A 3 -5.216 -33.394 3.703 1.00 1.00 C +ATOM 87 N2 G A 3 -6.316 -32.739 4.069 1.00 1.00 N +ATOM 88 N3 G A 3 -5.221 -34.151 2.601 1.00 1.00 N +ATOM 89 C4 G A 3 -4.022 -34.739 2.378 1.00 1.00 C +ATOM 90 H5' G A 3 -3.186 -38.984 -2.082 1.00 1.00 H +ATOM 91 H5'' G A 3 -3.006 -37.786 -3.380 1.00 1.00 H +ATOM 92 H4' G A 3 -5.118 -37.532 -2.070 1.00 1.00 H +ATOM 93 H3' G A 3 -3.098 -35.291 -2.143 1.00 1.00 H +ATOM 94 H2' G A 3 -4.282 -34.058 -0.594 1.00 1.00 H +ATOM 95 HO2' G A 3 -6.569 -34.331 -0.330 1.00 1.00 H +ATOM 96 H1' G A 3 -5.628 -36.183 0.724 1.00 1.00 H +ATOM 97 H8 G A 3 -1.864 -36.579 0.827 1.00 1.00 H +ATOM 98 H1 G A 3 -4.190 -32.648 5.332 1.00 1.00 H +ATOM 99 H21 G A 3 -6.311 -32.169 4.896 1.00 1.00 H +ATOM 100 H22 G A 3 -7.157 -32.815 3.513 1.00 1.00 H +ATOM 101 P A A 4 -4.518 -34.120 -4.179 1.00 1.00 P +ATOM 102 OP1 A A 4 -5.058 -34.385 -5.531 1.00 1.00 O +ATOM 103 OP2 A A 4 -3.079 -33.816 -4.007 1.00 1.00 O +ATOM 104 O5' A A 4 -5.369 -32.916 -3.524 1.00 1.00 O +ATOM 105 C5' A A 4 -6.781 -32.814 -3.739 1.00 1.00 C +ATOM 106 C4' A A 4 -7.414 -31.760 -2.832 1.00 1.00 C +ATOM 107 O4' A A 4 -7.129 -32.061 -1.467 1.00 1.00 O +ATOM 108 C3' A A 4 -6.918 -30.344 -3.080 1.00 1.00 C +ATOM 109 O3' A A 4 -7.779 -29.688 -4.018 1.00 1.00 O +ATOM 110 C2' A A 4 -7.033 -29.677 -1.718 1.00 1.00 C +ATOM 111 O2' A A 4 -8.282 -28.991 -1.578 1.00 1.00 O +ATOM 112 C1' A A 4 -6.927 -30.843 -0.735 1.00 1.00 C +ATOM 113 N9 A A 4 -5.618 -30.942 -0.068 1.00 1.00 N +ATOM 114 C8 A A 4 -4.458 -31.500 -0.539 1.00 1.00 C +ATOM 115 N7 A A 4 -3.461 -31.433 0.300 1.00 1.00 N +ATOM 116 C5 A A 4 -4.001 -30.786 1.406 1.00 1.00 C +ATOM 117 C6 A A 4 -3.455 -30.408 2.644 1.00 1.00 C +ATOM 118 N6 A A 4 -2.186 -30.641 2.982 1.00 1.00 N +ATOM 119 N1 A A 4 -4.267 -29.782 3.512 1.00 1.00 N +ATOM 120 C2 A A 4 -5.529 -29.553 3.167 1.00 1.00 C +ATOM 121 N3 A A 4 -6.157 -29.856 2.041 1.00 1.00 N +ATOM 122 C4 A A 4 -5.315 -30.482 1.192 1.00 1.00 C +ATOM 123 H5' A A 4 -7.243 -33.781 -3.539 1.00 1.00 H +ATOM 124 H5'' A A 4 -6.963 -32.542 -4.779 1.00 1.00 H +ATOM 125 H4' A A 4 -8.494 -31.782 -2.968 1.00 1.00 H +ATOM 126 H3' A A 4 -5.882 -30.349 -3.427 1.00 1.00 H +ATOM 127 H2' A A 4 -6.196 -28.990 -1.569 1.00 1.00 H +ATOM 128 HO2' A A 4 -8.808 -29.483 -0.944 1.00 1.00 H +ATOM 129 H1' A A 4 -7.706 -30.746 0.021 1.00 1.00 H +ATOM 130 H8 A A 4 -4.375 -31.956 -1.525 1.00 1.00 H +ATOM 131 H61 A A 4 -1.842 -30.348 3.887 1.00 1.00 H +ATOM 132 H62 A A 4 -1.568 -31.110 2.336 1.00 1.00 H +ATOM 133 H2 A A 4 -6.132 -29.042 3.918 1.00 1.00 H +ATOM 134 P U A 5 -7.193 -28.594 -5.046 1.00 1.00 P +ATOM 135 OP1 U A 5 -8.328 -28.012 -5.797 1.00 1.00 O +ATOM 136 OP2 U A 5 -6.060 -29.205 -5.775 1.00 1.00 O +ATOM 137 O5' U A 5 -6.608 -27.462 -4.061 1.00 1.00 O +ATOM 138 C5' U A 5 -7.479 -26.513 -3.442 1.00 1.00 C +ATOM 139 C4' U A 5 -6.780 -25.777 -2.304 1.00 1.00 C +ATOM 140 O4' U A 5 -6.200 -26.720 -1.408 1.00 1.00 O +ATOM 141 C3' U A 5 -5.657 -24.856 -2.754 1.00 1.00 C +ATOM 142 O3' U A 5 -6.172 -23.532 -2.940 1.00 1.00 O +ATOM 143 C2' U A 5 -4.686 -24.866 -1.580 1.00 1.00 C +ATOM 144 O2' U A 5 -4.885 -23.729 -0.733 1.00 1.00 O +ATOM 145 C1' U A 5 -5.006 -26.168 -0.841 1.00 1.00 C +ATOM 146 N1 U A 5 -3.944 -27.194 -0.943 1.00 1.00 N +ATOM 147 C2 U A 5 -3.060 -27.307 0.112 1.00 1.00 C +ATOM 148 O2 U A 5 -3.135 -26.590 1.108 1.00 1.00 O +ATOM 149 N3 U A 5 -2.083 -28.277 -0.015 1.00 1.00 N +ATOM 150 C4 U A 5 -1.915 -29.132 -1.092 1.00 1.00 C +ATOM 151 O4 U A 5 -1.007 -29.961 -1.099 1.00 1.00 O +ATOM 152 C5 U A 5 -2.884 -28.944 -2.148 1.00 1.00 C +ATOM 153 C6 U A 5 -3.850 -28.000 -2.045 1.00 1.00 C +ATOM 154 H5' U A 5 -8.349 -27.036 -3.045 1.00 1.00 H +ATOM 155 H5'' U A 5 -7.808 -25.789 -4.187 1.00 1.00 H +ATOM 156 H4' U A 5 -7.517 -25.193 -1.756 1.00 1.00 H +ATOM 157 H3' U A 5 -5.181 -25.231 -3.662 1.00 1.00 H +ATOM 158 H2' U A 5 -3.657 -24.894 -1.950 1.00 1.00 H +ATOM 159 HO2' U A 5 -4.737 -22.945 -1.269 1.00 1.00 H +ATOM 160 H1' U A 5 -5.187 -25.942 0.209 1.00 1.00 H +ATOM 161 H3 U A 5 -1.428 -28.372 0.749 1.00 1.00 H +ATOM 162 H5 U A 5 -2.836 -29.570 -3.040 1.00 1.00 H +ATOM 163 H6 U A 5 -4.569 -27.881 -2.857 1.00 1.00 H +ATOM 164 P A A 6 -5.836 -22.694 -4.273 1.00 1.00 P +ATOM 165 OP1 A A 6 -6.529 -23.336 -5.412 1.00 1.00 O +ATOM 166 OP2 A A 6 -4.373 -22.473 -4.327 1.00 1.00 O +ATOM 167 O5' A A 6 -6.549 -21.280 -3.980 1.00 1.00 O +ATOM 168 C5' A A 6 -7.811 -21.235 -3.311 1.00 1.00 C +ATOM 169 C4' A A 6 -7.664 -20.745 -1.869 1.00 1.00 C +ATOM 170 O4' A A 6 -6.404 -21.186 -1.352 1.00 1.00 O +ATOM 171 C3' A A 6 -7.729 -19.223 -1.706 1.00 1.00 C +ATOM 172 O3' A A 6 -8.664 -18.892 -0.671 1.00 1.00 O +ATOM 173 C2' A A 6 -6.326 -18.813 -1.276 1.00 1.00 C +ATOM 174 O2' A A 6 -6.369 -17.783 -0.280 1.00 1.00 O +ATOM 175 C1' A A 6 -5.734 -20.095 -0.717 1.00 1.00 C +ATOM 176 N9 A A 6 -4.285 -20.253 -0.964 1.00 1.00 N +ATOM 177 C8 A A 6 -3.630 -20.326 -2.166 1.00 1.00 C +ATOM 178 N7 A A 6 -2.338 -20.470 -2.054 1.00 1.00 N +ATOM 179 C5 A A 6 -2.123 -20.493 -0.679 1.00 1.00 C +ATOM 180 C6 A A 6 -0.960 -20.623 0.097 1.00 1.00 C +ATOM 181 N6 A A 6 0.258 -20.762 -0.429 1.00 1.00 N +ATOM 182 N1 A A 6 -1.104 -20.602 1.432 1.00 1.00 N +ATOM 183 C2 A A 6 -2.320 -20.465 1.950 1.00 1.00 C +ATOM 184 N3 A A 6 -3.483 -20.336 1.330 1.00 1.00 N +ATOM 185 C4 A A 6 -3.304 -20.359 -0.007 1.00 1.00 C +ATOM 186 H5' A A 6 -8.242 -22.237 -3.302 1.00 1.00 H +ATOM 187 H5'' A A 6 -8.481 -20.568 -3.855 1.00 1.00 H +ATOM 188 H4' A A 6 -8.453 -21.193 -1.267 1.00 1.00 H +ATOM 189 H3' A A 6 -7.999 -18.740 -2.646 1.00 1.00 H +ATOM 190 H2' A A 6 -5.751 -18.485 -2.145 1.00 1.00 H +ATOM 191 HO2' A A 6 -7.286 -17.676 -0.019 1.00 1.00 H +ATOM 192 H1' A A 6 -5.921 -20.135 0.349 1.00 1.00 H +ATOM 193 H8 A A 6 -4.141 -20.266 -3.127 1.00 1.00 H +ATOM 194 H61 A A 6 1.062 -20.851 0.175 1.00 1.00 H +ATOM 195 H62 A A 6 0.375 -20.777 -1.432 1.00 1.00 H +ATOM 196 H2 A A 6 -2.365 -20.454 3.039 1.00 1.00 H +ATOM 197 P U A 7 -8.548 -19.524 0.811 1.00 1.00 P +ATOM 198 OP1 U A 7 -7.814 -20.806 0.731 1.00 1.00 O +ATOM 199 OP2 U A 7 -9.891 -19.485 1.432 1.00 1.00 O +ATOM 200 O5' U A 7 -7.614 -18.461 1.576 1.00 1.00 O +ATOM 201 C5' U A 7 -8.085 -17.792 2.750 1.00 1.00 C +ATOM 202 C4' U A 7 -7.263 -18.172 3.978 1.00 1.00 C +ATOM 203 O4' U A 7 -7.359 -19.572 4.210 1.00 1.00 O +ATOM 204 C3' U A 7 -5.783 -17.850 3.844 1.00 1.00 C +ATOM 205 O3' U A 7 -5.516 -16.586 4.460 1.00 1.00 O +ATOM 206 C2' U A 7 -5.076 -18.955 4.622 1.00 1.00 C +ATOM 207 O2' U A 7 -4.604 -18.474 5.886 1.00 1.00 O +ATOM 208 C1' U A 7 -6.149 -20.039 4.814 1.00 1.00 C +ATOM 209 N1 U A 7 -5.823 -21.347 4.191 1.00 1.00 N +ATOM 210 C2 U A 7 -6.080 -22.493 4.919 1.00 1.00 C +ATOM 211 O2 U A 7 -6.544 -22.454 6.057 1.00 1.00 O +ATOM 212 N3 U A 7 -5.784 -23.690 4.292 1.00 1.00 N +ATOM 213 C4 U A 7 -5.261 -23.839 3.019 1.00 1.00 C +ATOM 214 O4 U A 7 -5.034 -24.957 2.561 1.00 1.00 O +ATOM 215 C5 U A 7 -5.025 -22.590 2.331 1.00 1.00 C +ATOM 216 C6 U A 7 -5.308 -21.405 2.924 1.00 1.00 C +ATOM 217 H5' U A 7 -9.127 -18.061 2.920 1.00 1.00 H +ATOM 218 H5'' U A 7 -8.017 -16.715 2.595 1.00 1.00 H +ATOM 219 H4' U A 7 -7.662 -17.651 4.845 1.00 1.00 H +ATOM 220 H3' U A 7 -5.475 -17.853 2.798 1.00 1.00 H +ATOM 221 H2' U A 7 -4.242 -19.347 4.028 1.00 1.00 H +ATOM 222 HO2' U A 7 -3.860 -19.024 6.142 1.00 1.00 H +ATOM 223 H1' U A 7 -6.318 -20.179 5.883 1.00 1.00 H +ATOM 224 H3 U A 7 -5.965 -24.536 4.814 1.00 1.00 H +ATOM 225 H5 U A 7 -4.615 -22.602 1.321 1.00 1.00 H +ATOM 226 H6 U A 7 -5.120 -20.478 2.381 1.00 1.00 H +ATOM 227 P G A 8 -4.280 -15.684 3.964 1.00 1.00 P +ATOM 228 OP1 G A 8 -4.258 -14.443 4.770 1.00 1.00 O +ATOM 229 OP2 G A 8 -4.331 -15.602 2.487 1.00 1.00 O +ATOM 230 O5' G A 8 -3.003 -16.575 4.375 1.00 1.00 O +ATOM 231 C5' G A 8 -2.428 -17.499 3.444 1.00 1.00 C +ATOM 232 C4' G A 8 -1.241 -16.887 2.702 1.00 1.00 C +ATOM 233 O4' G A 8 -0.948 -17.672 1.546 1.00 1.00 O +ATOM 234 C3' G A 8 -1.477 -15.458 2.232 1.00 1.00 C +ATOM 235 O3' G A 8 -0.889 -14.541 3.157 1.00 1.00 O +ATOM 236 C2' G A 8 -0.745 -15.373 0.905 1.00 1.00 C +ATOM 237 O2' G A 8 0.560 -14.803 1.062 1.00 1.00 O +ATOM 238 C1' G A 8 -0.668 -16.817 0.430 1.00 1.00 C +ATOM 239 N9 G A 8 -1.638 -17.134 -0.631 1.00 1.00 N +ATOM 240 C8 G A 8 -2.955 -17.494 -0.511 1.00 1.00 C +ATOM 241 N7 G A 8 -3.553 -17.706 -1.648 1.00 1.00 N +ATOM 242 C5 G A 8 -2.562 -17.473 -2.597 1.00 1.00 C +ATOM 243 C6 G A 8 -2.628 -17.549 -4.015 1.00 1.00 C +ATOM 244 O6 G A 8 -3.593 -17.841 -4.720 1.00 1.00 O +ATOM 245 N1 G A 8 -1.408 -17.239 -4.600 1.00 1.00 N +ATOM 246 C2 G A 8 -0.266 -16.896 -3.910 1.00 1.00 C +ATOM 247 N2 G A 8 0.812 -16.634 -4.650 1.00 1.00 N +ATOM 248 N3 G A 8 -0.200 -16.822 -2.574 1.00 1.00 N +ATOM 249 C4 G A 8 -1.384 -17.121 -1.986 1.00 1.00 C +ATOM 250 H5' G A 8 -3.187 -17.792 2.720 1.00 1.00 H +ATOM 251 H5'' G A 8 -2.091 -18.384 3.983 1.00 1.00 H +ATOM 252 H4' G A 8 -0.371 -16.903 3.357 1.00 1.00 H +ATOM 253 H3' G A 8 -2.540 -15.261 2.096 1.00 1.00 H +ATOM 254 H2' G A 8 -1.338 -14.790 0.199 1.00 1.00 H +ATOM 255 HO2' G A 8 0.644 -14.099 0.414 1.00 1.00 H +ATOM 256 H1' G A 8 0.338 -17.022 0.064 1.00 1.00 H +ATOM 257 H8 G A 8 -3.456 -17.599 0.452 1.00 1.00 H +ATOM 258 H1 G A 8 -1.378 -17.271 -5.609 1.00 1.00 H +ATOM 259 H21 G A 8 0.756 -16.691 -5.654 1.00 1.00 H +ATOM 260 H22 G A 8 1.679 -16.378 -4.209 1.00 1.00 H +ATOM 261 P G A 9 -1.120 -12.957 2.988 1.00 1.00 P +ATOM 262 OP1 G A 9 -0.349 -12.261 4.043 1.00 1.00 O +ATOM 263 OP2 G A 9 -2.573 -12.714 2.852 1.00 1.00 O +ATOM 264 O5' G A 9 -0.421 -12.650 1.571 1.00 1.00 O +ATOM 265 C5' G A 9 -1.093 -11.855 0.589 1.00 1.00 C +ATOM 266 C4' G A 9 -0.152 -11.444 -0.538 1.00 1.00 C +ATOM 267 O4' G A 9 0.181 -12.587 -1.328 1.00 1.00 O +ATOM 268 C3' G A 9 -0.739 -10.405 -1.483 1.00 1.00 C +ATOM 269 O3' G A 9 -0.340 -9.095 -1.065 1.00 1.00 O +ATOM 270 C2' G A 9 -0.099 -10.737 -2.822 1.00 1.00 C +ATOM 271 O2' G A 9 1.107 -9.991 -3.023 1.00 1.00 O +ATOM 272 C1' G A 9 0.182 -12.232 -2.718 1.00 1.00 C +ATOM 273 N9 G A 9 -0.823 -13.074 -3.392 1.00 1.00 N +ATOM 274 C8 G A 9 -1.853 -13.793 -2.840 1.00 1.00 C +ATOM 275 N7 G A 9 -2.572 -14.442 -3.713 1.00 1.00 N +ATOM 276 C5 G A 9 -1.978 -14.133 -4.934 1.00 1.00 C +ATOM 277 C6 G A 9 -2.326 -14.549 -6.249 1.00 1.00 C +ATOM 278 O6 G A 9 -3.245 -15.288 -6.597 1.00 1.00 O +ATOM 279 N1 G A 9 -1.468 -14.010 -7.198 1.00 1.00 N +ATOM 280 C2 G A 9 -0.408 -13.172 -6.921 1.00 1.00 C +ATOM 281 N2 G A 9 0.304 -12.754 -7.969 1.00 1.00 N +ATOM 282 N3 G A 9 -0.080 -12.778 -5.687 1.00 1.00 N +ATOM 283 C4 G A 9 -0.906 -13.295 -4.746 1.00 1.00 C +ATOM 284 H5' G A 9 -1.491 -10.960 1.066 1.00 1.00 H +ATOM 285 H5'' G A 9 -1.919 -12.431 0.170 1.00 1.00 H +ATOM 286 H4' G A 9 0.763 -11.047 -0.104 1.00 1.00 H +ATOM 287 H3' G A 9 -1.825 -10.494 -1.536 1.00 1.00 H +ATOM 288 H2' G A 9 -0.809 -10.550 -3.629 1.00 1.00 H +ATOM 289 HO2' G A 9 1.276 -9.500 -2.216 1.00 1.00 H +ATOM 290 H1' G A 9 1.164 -12.442 -3.142 1.00 1.00 H +ATOM 291 H8 G A 9 -2.051 -13.821 -1.769 1.00 1.00 H +ATOM 292 H1 G A 9 -1.652 -14.261 -8.158 1.00 1.00 H +ATOM 293 H21 G A 9 0.054 -13.054 -8.903 1.00 1.00 H +ATOM 294 H22 G A 9 1.093 -12.139 -7.830 1.00 1.00 H +ATOM 295 P A A 10 -1.415 -7.897 -0.976 1.00 1.00 P +ATOM 296 OP1 A A 10 -0.835 -6.817 -0.147 1.00 1.00 O +ATOM 297 OP2 A A 10 -2.728 -8.480 -0.615 1.00 1.00 O +ATOM 298 O5' A A 10 -1.497 -7.376 -2.498 1.00 1.00 O +ATOM 299 C5' A A 10 -0.372 -6.736 -3.107 1.00 1.00 C +ATOM 300 C4' A A 10 -0.523 -6.660 -4.624 1.00 1.00 C +ATOM 301 O4' A A 10 -0.585 -7.970 -5.175 1.00 1.00 O +ATOM 302 C3' A A 10 -1.776 -5.942 -5.099 1.00 1.00 C +ATOM 303 O3' A A 10 -1.510 -4.541 -5.244 1.00 1.00 O +ATOM 304 C2' A A 10 -2.042 -6.564 -6.461 1.00 1.00 C +ATOM 305 O2' A A 10 -1.490 -5.767 -7.516 1.00 1.00 O +ATOM 306 C1' A A 10 -1.360 -7.930 -6.380 1.00 1.00 C +ATOM 307 N9 A A 10 -2.300 -9.066 -6.356 1.00 1.00 N +ATOM 308 C8 A A 10 -2.944 -9.635 -5.287 1.00 1.00 C +ATOM 309 N7 A A 10 -3.723 -10.631 -5.609 1.00 1.00 N +ATOM 310 C5 A A 10 -3.585 -10.726 -6.991 1.00 1.00 C +ATOM 311 C6 A A 10 -4.154 -11.589 -7.944 1.00 1.00 C +ATOM 312 N6 A A 10 -5.011 -12.560 -7.629 1.00 1.00 N +ATOM 313 N1 A A 10 -3.802 -11.408 -9.228 1.00 1.00 N +ATOM 314 C2 A A 10 -2.946 -10.438 -9.535 1.00 1.00 C +ATOM 315 N3 A A 10 -2.348 -9.569 -8.735 1.00 1.00 N +ATOM 316 C4 A A 10 -2.721 -9.776 -7.454 1.00 1.00 C +ATOM 317 H5' A A 10 0.529 -7.300 -2.868 1.00 1.00 H +ATOM 318 H5'' A A 10 -0.278 -5.727 -2.707 1.00 1.00 H +ATOM 319 H4' A A 10 0.348 -6.158 -5.038 1.00 1.00 H +ATOM 320 H3' A A 10 -2.611 -6.122 -4.419 1.00 1.00 H +ATOM 321 H2' A A 10 -3.116 -6.698 -6.602 1.00 1.00 H +ATOM 322 HO2' A A 10 -2.158 -5.125 -7.768 1.00 1.00 H +ATOM 323 H1' A A 10 -0.694 -8.043 -7.234 1.00 1.00 H +ATOM 324 H8 A A 10 -2.817 -9.288 -4.261 1.00 1.00 H +ATOM 325 H61 A A 10 -5.391 -13.153 -8.354 1.00 1.00 H +ATOM 326 H62 A A 10 -5.282 -12.705 -6.666 1.00 1.00 H +ATOM 327 H2 A A 10 -2.705 -10.347 -10.593 1.00 1.00 H +ATOM 328 P A A 11 -2.719 -3.476 -5.293 1.00 1.00 P +ATOM 329 OP1 A A 11 -2.193 -2.162 -4.856 1.00 1.00 O +ATOM 330 OP2 A A 11 -3.887 -4.068 -4.604 1.00 1.00 O +ATOM 331 O5' A A 11 -3.052 -3.383 -6.868 1.00 1.00 O +ATOM 332 C5' A A 11 -2.134 -2.755 -7.772 1.00 1.00 C +ATOM 333 C4' A A 11 -2.488 -3.043 -9.231 1.00 1.00 C +ATOM 334 O4' A A 11 -2.595 -4.455 -9.430 1.00 1.00 O +ATOM 335 C3' A A 11 -3.804 -2.427 -9.690 1.00 1.00 C +ATOM 336 O3' A A 11 -3.554 -1.146 -10.283 1.00 1.00 O +ATOM 337 C2' A A 11 -4.280 -3.411 -10.748 1.00 1.00 C +ATOM 338 O2' A A 11 -3.737 -3.105 -12.037 1.00 1.00 O +ATOM 339 C1' A A 11 -3.756 -4.737 -10.221 1.00 1.00 C +ATOM 340 N9 A A 11 -4.718 -5.446 -9.365 1.00 1.00 N +ATOM 341 C8 A A 11 -4.849 -5.416 -8.001 1.00 1.00 C +ATOM 342 N7 A A 11 -5.808 -6.173 -7.545 1.00 1.00 N +ATOM 343 C5 A A 11 -6.351 -6.748 -8.691 1.00 1.00 C +ATOM 344 C6 A A 11 -7.407 -7.652 -8.891 1.00 1.00 C +ATOM 345 N6 A A 11 -8.133 -8.159 -7.893 1.00 1.00 N +ATOM 346 N1 A A 11 -7.680 -8.010 -10.157 1.00 1.00 N +ATOM 347 C2 A A 11 -6.954 -7.502 -11.146 1.00 1.00 C +ATOM 348 N3 A A 11 -5.942 -6.650 -11.086 1.00 1.00 N +ATOM 349 C4 A A 11 -5.692 -6.310 -9.804 1.00 1.00 C +ATOM 350 H5' A A 11 -1.129 -3.124 -7.569 1.00 1.00 H +ATOM 351 H5'' A A 11 -2.158 -1.677 -7.608 1.00 1.00 H +ATOM 352 H4' A A 11 -1.687 -2.669 -9.864 1.00 1.00 H +ATOM 353 H3' A A 11 -4.518 -2.359 -8.866 1.00 1.00 H +ATOM 354 H2' A A 11 -5.367 -3.436 -10.783 1.00 1.00 H +ATOM 355 HO2' A A 11 -4.437 -3.249 -12.679 1.00 1.00 H +ATOM 356 H1' A A 11 -3.481 -5.380 -11.057 1.00 1.00 H +ATOM 357 H8 A A 11 -4.211 -4.811 -7.355 1.00 1.00 H +ATOM 358 H61 A A 11 -8.880 -8.803 -8.094 1.00 1.00 H +ATOM 359 H62 A A 11 -7.936 -7.895 -6.937 1.00 1.00 H +ATOM 360 H2 A A 11 -7.229 -7.835 -12.147 1.00 1.00 H +ATOM 361 P G A 12 -4.395 0.154 -9.823 1.00 1.00 P +ATOM 362 OP1 G A 12 -3.734 1.350 -10.392 1.00 1.00 O +ATOM 363 OP2 G A 12 -4.617 0.062 -8.363 1.00 1.00 O +ATOM 364 O5' G A 12 -5.815 -0.030 -10.560 1.00 1.00 O +ATOM 365 C5' G A 12 -5.986 0.376 -11.921 1.00 1.00 C +ATOM 366 C4' G A 12 -7.363 -0.010 -12.458 1.00 1.00 C +ATOM 367 O4' G A 12 -7.489 -1.429 -12.500 1.00 1.00 O +ATOM 368 C3' G A 12 -8.537 0.503 -11.632 1.00 1.00 C +ATOM 369 O3' G A 12 -8.923 1.804 -12.101 1.00 1.00 O +ATOM 370 C2' G A 12 -9.628 -0.512 -11.933 1.00 1.00 C +ATOM 371 O2' G A 12 -10.417 -0.117 -13.058 1.00 1.00 O +ATOM 372 C1' G A 12 -8.848 -1.791 -12.217 1.00 1.00 C +ATOM 373 N9 G A 12 -8.841 -2.747 -11.095 1.00 1.00 N +ATOM 374 C8 G A 12 -7.922 -2.893 -10.088 1.00 1.00 C +ATOM 375 N7 G A 12 -8.199 -3.858 -9.256 1.00 1.00 N +ATOM 376 C5 G A 12 -9.389 -4.390 -9.744 1.00 1.00 C +ATOM 377 C6 G A 12 -10.176 -5.467 -9.250 1.00 1.00 C +ATOM 378 O6 G A 12 -9.970 -6.175 -8.267 1.00 1.00 O +ATOM 379 N1 G A 12 -11.300 -5.679 -10.036 1.00 1.00 N +ATOM 380 C2 G A 12 -11.630 -4.948 -11.158 1.00 1.00 C +ATOM 381 N2 G A 12 -12.754 -5.299 -11.782 1.00 1.00 N +ATOM 382 N3 G A 12 -10.891 -3.937 -11.625 1.00 1.00 N +ATOM 383 C4 G A 12 -9.789 -3.715 -10.869 1.00 1.00 C +ATOM 384 H5' G A 12 -5.220 -0.102 -12.532 1.00 1.00 H +ATOM 385 H5'' G A 12 -5.869 1.458 -11.986 1.00 1.00 H +ATOM 386 H4' G A 12 -7.459 0.369 -13.472 1.00 1.00 H +ATOM 387 H3' G A 12 -8.293 0.515 -10.568 1.00 1.00 H +ATOM 388 H2' G A 12 -10.255 -0.661 -11.052 1.00 1.00 H +ATOM 389 HO2' G A 12 -11.274 -0.543 -12.969 1.00 1.00 H +ATOM 390 H1' G A 12 -9.275 -2.279 -13.093 1.00 1.00 H +ATOM 391 H8 G A 12 -7.039 -2.261 -9.992 1.00 1.00 H +ATOM 392 H1 G A 12 -11.910 -6.431 -9.748 1.00 1.00 H +ATOM 393 H21 G A 12 -13.309 -6.059 -11.430 1.00 1.00 H +ATOM 394 H22 G A 12 -13.047 -4.801 -12.610 1.00 1.00 H +ATOM 395 P A A 13 -9.683 2.849 -11.132 1.00 1.00 P +ATOM 396 OP1 A A 13 -9.743 4.156 -11.825 1.00 1.00 O +ATOM 397 OP2 A A 13 -9.076 2.756 -9.785 1.00 1.00 O +ATOM 398 O5' A A 13 -11.182 2.256 -11.053 1.00 1.00 O +ATOM 399 C5' A A 13 -12.046 2.311 -12.194 1.00 1.00 C +ATOM 400 C4' A A 13 -13.333 1.518 -11.973 1.00 1.00 C +ATOM 401 O4' A A 13 -13.034 0.131 -11.815 1.00 1.00 O +ATOM 402 C3' A A 13 -14.130 1.931 -10.742 1.00 1.00 C +ATOM 403 O3' A A 13 -15.077 2.952 -11.091 1.00 1.00 O +ATOM 404 C2' A A 13 -14.865 0.658 -10.367 1.00 1.00 C +ATOM 405 O2' A A 13 -16.166 0.606 -10.963 1.00 1.00 O +ATOM 406 C1' A A 13 -13.962 -0.451 -10.887 1.00 1.00 C +ATOM 407 N9 A A 13 -13.200 -1.132 -9.828 1.00 1.00 N +ATOM 408 C8 A A 13 -12.049 -0.740 -9.197 1.00 1.00 C +ATOM 409 N7 A A 13 -11.627 -1.584 -8.296 1.00 1.00 N +ATOM 410 C5 A A 13 -12.570 -2.609 -8.333 1.00 1.00 C +ATOM 411 C6 A A 13 -12.696 -3.810 -7.615 1.00 1.00 C +ATOM 412 N6 A A 13 -11.830 -4.195 -6.676 1.00 1.00 N +ATOM 413 N1 A A 13 -13.749 -4.592 -7.904 1.00 1.00 N +ATOM 414 C2 A A 13 -14.609 -4.204 -8.838 1.00 1.00 C +ATOM 415 N3 A A 13 -14.599 -3.105 -9.578 1.00 1.00 N +ATOM 416 C4 A A 13 -13.531 -2.340 -9.266 1.00 1.00 C +ATOM 417 H5' A A 13 -11.520 1.899 -13.055 1.00 1.00 H +ATOM 418 H5'' A A 13 -12.300 3.352 -12.398 1.00 1.00 H +ATOM 419 H4' A A 13 -13.966 1.630 -12.851 1.00 1.00 H +ATOM 420 H3' A A 13 -13.469 2.255 -9.937 1.00 1.00 H +ATOM 421 H2' A A 13 -14.930 0.582 -9.287 1.00 1.00 H +ATOM 422 HO2' A A 13 -16.467 1.510 -11.066 1.00 1.00 H +ATOM 423 H1' A A 13 -14.568 -1.190 -11.410 1.00 1.00 H +ATOM 424 H8 A A 13 -11.531 0.193 -9.426 1.00 1.00 H +ATOM 425 H61 A A 13 -11.970 -5.066 -6.194 1.00 1.00 H +ATOM 426 H62 A A 13 -11.035 -3.615 -6.452 1.00 1.00 H +ATOM 427 H2 A A 13 -15.440 -4.885 -9.022 1.00 1.00 H +ATOM 428 P A A 14 -15.721 3.906 -9.958 1.00 1.00 P +ATOM 429 OP1 A A 14 -16.178 5.152 -10.612 1.00 1.00 O +ATOM 430 OP2 A A 14 -14.774 3.976 -8.822 1.00 1.00 O +ATOM 431 O5' A A 14 -17.027 3.087 -9.475 1.00 1.00 O +ATOM 432 C5' A A 14 -18.236 3.105 -10.246 1.00 1.00 C +ATOM 433 C4' A A 14 -19.345 2.277 -9.589 1.00 1.00 C +ATOM 434 O4' A A 14 -18.933 0.909 -9.502 1.00 1.00 O +ATOM 435 C3' A A 14 -19.712 2.722 -8.177 1.00 1.00 C +ATOM 436 O3' A A 14 -20.849 3.594 -8.221 1.00 1.00 O +ATOM 437 C2' A A 14 -20.086 1.419 -7.490 1.00 1.00 C +ATOM 438 O2' A A 14 -21.464 1.089 -7.698 1.00 1.00 O +ATOM 439 C1' A A 14 -19.165 0.423 -8.172 1.00 1.00 C +ATOM 440 N9 A A 14 -17.854 0.286 -7.517 1.00 1.00 N +ATOM 441 C8 A A 14 -16.737 1.070 -7.658 1.00 1.00 C +ATOM 442 N7 A A 14 -15.714 0.658 -6.962 1.00 1.00 N +ATOM 443 C5 A A 14 -16.186 -0.479 -6.314 1.00 1.00 C +ATOM 444 C6 A A 14 -15.586 -1.383 -5.422 1.00 1.00 C +ATOM 445 N6 A A 14 -14.321 -1.273 -5.013 1.00 1.00 N +ATOM 446 N1 A A 14 -16.342 -2.397 -4.971 1.00 1.00 N +ATOM 447 C2 A A 14 -17.600 -2.501 -5.381 1.00 1.00 C +ATOM 448 N3 A A 14 -18.274 -1.722 -6.212 1.00 1.00 N +ATOM 449 C4 A A 14 -17.491 -0.713 -6.647 1.00 1.00 C +ATOM 450 H5' A A 14 -18.030 2.702 -11.238 1.00 1.00 H +ATOM 451 H5'' A A 14 -18.578 4.136 -10.345 1.00 1.00 H +ATOM 452 H4' A A 14 -20.234 2.327 -10.214 1.00 1.00 H +ATOM 453 H3' A A 14 -18.863 3.197 -7.681 1.00 1.00 H +ATOM 454 H2' A A 14 -19.854 1.474 -6.425 1.00 1.00 H +ATOM 455 HO2' A A 14 -21.754 0.586 -6.933 1.00 1.00 H +ATOM 456 H1' A A 14 -19.648 -0.553 -8.218 1.00 1.00 H +ATOM 457 H8 A A 14 -16.709 1.956 -8.292 1.00 1.00 H +ATOM 458 H61 A A 14 -13.935 -1.956 -4.367 1.00 1.00 H +ATOM 459 H62 A A 14 -13.745 -0.513 -5.348 1.00 1.00 H +ATOM 460 H2 A A 14 -18.155 -3.347 -4.976 1.00 1.00 H +ATOM 461 P C A 15 -21.037 4.755 -7.119 1.00 1.00 P +ATOM 462 OP1 C A 15 -22.367 5.373 -7.320 1.00 1.00 O +ATOM 463 OP2 C A 15 -19.823 5.601 -7.129 1.00 1.00 O +ATOM 464 O5' C A 15 -21.068 3.938 -5.729 1.00 1.00 O +ATOM 465 C5' C A 15 -22.273 3.314 -5.275 1.00 1.00 C +ATOM 466 C4' C A 15 -22.057 2.569 -3.960 1.00 1.00 C +ATOM 467 O4' C A 15 -21.155 1.482 -4.149 1.00 1.00 O +ATOM 468 C3' C A 15 -21.461 3.414 -2.850 1.00 1.00 C +ATOM 469 O3' C A 15 -22.500 4.086 -2.131 1.00 1.00 O +ATOM 470 C2' C A 15 -20.789 2.382 -1.957 1.00 1.00 C +ATOM 471 O2' C A 15 -21.676 1.923 -0.930 1.00 1.00 O +ATOM 472 C1' C A 15 -20.431 1.253 -2.926 1.00 1.00 C +ATOM 473 N1 C A 15 -18.992 1.196 -3.266 1.00 1.00 N +ATOM 474 C2 C A 15 -18.201 0.276 -2.595 1.00 1.00 C +ATOM 475 O2 C A 15 -18.699 -0.459 -1.745 1.00 1.00 O +ATOM 476 N3 C A 15 -16.877 0.215 -2.905 1.00 1.00 N +ATOM 477 C4 C A 15 -16.350 1.023 -3.836 1.00 1.00 C +ATOM 478 N4 C A 15 -15.049 0.941 -4.116 1.00 1.00 N +ATOM 479 C5 C A 15 -17.163 1.972 -4.531 1.00 1.00 C +ATOM 480 C6 C A 15 -18.472 2.025 -4.218 1.00 1.00 C +ATOM 481 H5' C A 15 -22.616 2.608 -6.032 1.00 1.00 H +ATOM 482 H5'' C A 15 -23.037 4.078 -5.130 1.00 1.00 H +ATOM 483 H4' C A 15 -23.010 2.168 -3.622 1.00 1.00 H +ATOM 484 H3' C A 15 -20.730 4.120 -3.248 1.00 1.00 H +ATOM 485 H2' C A 15 -19.880 2.799 -1.523 1.00 1.00 H +ATOM 486 HO2' C A 15 -22.323 1.351 -1.347 1.00 1.00 H +ATOM 487 H1' C A 15 -20.741 0.301 -2.499 1.00 1.00 H +ATOM 488 H41 C A 15 -14.469 0.271 -3.624 1.00 1.00 H +ATOM 489 H42 C A 15 -14.641 1.545 -4.816 1.00 1.00 H +ATOM 490 H5 C A 15 -16.738 2.630 -5.291 1.00 1.00 H +ATOM 491 H6 C A 15 -19.121 2.736 -4.728 1.00 1.00 H +ATOM 492 P C A 16 -22.190 5.460 -1.348 1.00 1.00 P +ATOM 493 OP1 C A 16 -23.398 5.836 -0.580 1.00 1.00 O +ATOM 494 OP2 C A 16 -21.597 6.417 -2.309 1.00 1.00 O +ATOM 495 O5' C A 16 -21.048 5.015 -0.303 1.00 1.00 O +ATOM 496 C5' C A 16 -21.358 4.115 0.762 1.00 1.00 C +ATOM 497 C4' C A 16 -20.108 3.433 1.312 1.00 1.00 C +ATOM 498 O4' C A 16 -19.382 2.820 0.254 1.00 1.00 O +ATOM 499 C3' C A 16 -19.128 4.363 2.012 1.00 1.00 C +ATOM 500 O3' C A 16 -19.441 4.424 3.409 1.00 1.00 O +ATOM 501 C2' C A 16 -17.788 3.668 1.831 1.00 1.00 C +ATOM 502 O2' C A 16 -17.417 2.928 3.000 1.00 1.00 O +ATOM 503 C1' C A 16 -18.002 2.749 0.630 1.00 1.00 C +ATOM 504 N1 C A 16 -17.161 3.081 -0.543 1.00 1.00 N +ATOM 505 C2 C A 16 -15.970 2.383 -0.673 1.00 1.00 C +ATOM 506 O2 C A 16 -15.652 1.547 0.171 1.00 1.00 O +ATOM 507 N3 C A 16 -15.178 2.651 -1.747 1.00 1.00 N +ATOM 508 C4 C A 16 -15.538 3.568 -2.655 1.00 1.00 C +ATOM 509 N4 C A 16 -14.740 3.804 -3.696 1.00 1.00 N +ATOM 510 C5 C A 16 -16.765 4.292 -2.525 1.00 1.00 C +ATOM 511 C6 C A 16 -17.542 4.020 -1.458 1.00 1.00 C +ATOM 512 H5' C A 16 -22.044 3.354 0.394 1.00 1.00 H +ATOM 513 H5'' C A 16 -21.843 4.670 1.565 1.00 1.00 H +ATOM 514 H4' C A 16 -20.413 2.656 2.009 1.00 1.00 H +ATOM 515 H3' C A 16 -19.126 5.353 1.555 1.00 1.00 H +ATOM 516 H2' C A 16 -17.027 4.408 1.585 1.00 1.00 H +ATOM 517 HO2' C A 16 -16.741 2.299 2.737 1.00 1.00 H +ATOM 518 H1' C A 16 -17.787 1.723 0.940 1.00 1.00 H +ATOM 519 H41 C A 16 -13.873 3.295 -3.792 1.00 1.00 H +ATOM 520 H42 C A 16 -15.000 4.493 -4.388 1.00 1.00 H +ATOM 521 H5 C A 16 -17.061 5.038 -3.263 1.00 1.00 H +ATOM 522 H6 C A 16 -18.482 4.554 -1.324 1.00 1.00 H +ATOM 523 P G A 17 -18.687 5.468 4.377 1.00 1.00 P +ATOM 524 OP1 G A 17 -19.567 5.743 5.534 1.00 1.00 O +ATOM 525 OP2 G A 17 -18.188 6.588 3.547 1.00 1.00 O +ATOM 526 O5' G A 17 -17.414 4.624 4.901 1.00 1.00 O +ATOM 527 C5' G A 17 -17.588 3.491 5.762 1.00 1.00 C +ATOM 528 C4' G A 17 -16.248 2.895 6.199 1.00 1.00 C +ATOM 529 O4' G A 17 -15.590 2.287 5.087 1.00 1.00 O +ATOM 530 C3' G A 17 -15.274 3.909 6.780 1.00 1.00 C +ATOM 531 O3' G A 17 -15.427 3.981 8.200 1.00 1.00 O +ATOM 532 C2' G A 17 -13.910 3.331 6.443 1.00 1.00 C +ATOM 533 O2' G A 17 -13.412 2.514 7.508 1.00 1.00 O +ATOM 534 C1' G A 17 -14.174 2.510 5.187 1.00 1.00 C +ATOM 535 N9 G A 17 -13.746 3.176 3.949 1.00 1.00 N +ATOM 536 C8 G A 17 -14.501 3.914 3.073 1.00 1.00 C +ATOM 537 N7 G A 17 -13.826 4.384 2.061 1.00 1.00 N +ATOM 538 C5 G A 17 -12.532 3.925 2.278 1.00 1.00 C +ATOM 539 C6 G A 17 -11.354 4.122 1.504 1.00 1.00 C +ATOM 540 O6 G A 17 -11.226 4.751 0.456 1.00 1.00 O +ATOM 541 N1 G A 17 -10.258 3.491 2.076 1.00 1.00 N +ATOM 542 C2 G A 17 -10.285 2.762 3.244 1.00 1.00 C +ATOM 543 N2 G A 17 -9.125 2.232 3.634 1.00 1.00 N +ATOM 544 N3 G A 17 -11.390 2.574 3.974 1.00 1.00 N +ATOM 545 C4 G A 17 -12.472 3.184 3.432 1.00 1.00 C +ATOM 546 H5' G A 17 -18.159 2.728 5.231 1.00 1.00 H +ATOM 547 H5'' G A 17 -18.145 3.799 6.646 1.00 1.00 H +ATOM 548 H4' G A 17 -16.436 2.125 6.945 1.00 1.00 H +ATOM 549 H3' G A 17 -15.408 4.887 6.315 1.00 1.00 H +ATOM 550 H2' G A 17 -13.211 4.140 6.217 1.00 1.00 H +ATOM 551 HO2' G A 17 -13.407 1.608 7.193 1.00 1.00 H +ATOM 552 H1' G A 17 -13.663 1.551 5.270 1.00 1.00 H +ATOM 553 H8 G A 17 -15.567 4.092 3.210 1.00 1.00 H +ATOM 554 H1 G A 17 -9.383 3.587 1.580 1.00 1.00 H +ATOM 555 H21 G A 17 -8.294 2.377 3.080 1.00 1.00 H +ATOM 556 H22 G A 17 -9.079 1.687 4.483 1.00 1.00 H +ATOM 557 P G A 18 -14.935 5.289 9.000 1.00 1.00 P +ATOM 558 OP1 G A 18 -15.128 5.046 10.446 1.00 1.00 O +ATOM 559 OP2 G A 18 -15.547 6.477 8.362 1.00 1.00 O +ATOM 560 O5' G A 18 -13.351 5.315 8.698 1.00 1.00 O +ATOM 561 C5' G A 18 -12.489 4.303 9.233 1.00 1.00 C +ATOM 562 C4' G A 18 -11.025 4.559 8.881 1.00 1.00 C +ATOM 563 O4' G A 18 -10.791 4.332 7.495 1.00 1.00 O +ATOM 564 C3' G A 18 -10.548 5.973 9.159 1.00 1.00 C +ATOM 565 O3' G A 18 -10.080 6.072 10.507 1.00 1.00 O +ATOM 566 C2' G A 18 -9.393 6.154 8.185 1.00 1.00 C +ATOM 567 O2' G A 18 -8.135 5.883 8.810 1.00 1.00 O +ATOM 568 C1' G A 18 -9.691 5.151 7.070 1.00 1.00 C +ATOM 569 N9 G A 18 -10.070 5.776 5.789 1.00 1.00 N +ATOM 570 C8 G A 18 -11.301 6.226 5.388 1.00 1.00 C +ATOM 571 N7 G A 18 -11.315 6.728 4.185 1.00 1.00 N +ATOM 572 C5 G A 18 -9.998 6.602 3.754 1.00 1.00 C +ATOM 573 C6 G A 18 -9.405 6.977 2.516 1.00 1.00 C +ATOM 574 O6 G A 18 -9.939 7.504 1.543 1.00 1.00 O +ATOM 575 N1 G A 18 -8.050 6.676 2.488 1.00 1.00 N +ATOM 576 C2 G A 18 -7.350 6.087 3.520 1.00 1.00 C +ATOM 577 N2 G A 18 -6.052 5.877 3.306 1.00 1.00 N +ATOM 578 N3 G A 18 -7.905 5.734 4.684 1.00 1.00 N +ATOM 579 C4 G A 18 -9.228 6.021 4.730 1.00 1.00 C +ATOM 580 H5' G A 18 -12.787 3.335 8.828 1.00 1.00 H +ATOM 581 H5'' G A 18 -12.596 4.281 10.317 1.00 1.00 H +ATOM 582 H4' G A 18 -10.406 3.867 9.447 1.00 1.00 H +ATOM 583 H3' G A 18 -11.343 6.696 8.958 1.00 1.00 H +ATOM 584 H2' G A 18 -9.411 7.165 7.779 1.00 1.00 H +ATOM 585 HO2' G A 18 -7.539 6.597 8.569 1.00 1.00 H +ATOM 586 H1' G A 18 -8.817 4.522 6.912 1.00 1.00 H +ATOM 587 H8 G A 18 -12.190 6.169 6.018 1.00 1.00 H +ATOM 588 H1 G A 18 -7.559 6.915 1.639 1.00 1.00 H +ATOM 589 H21 G A 18 -5.635 6.145 2.425 1.00 1.00 H +ATOM 590 H22 G A 18 -5.485 5.449 4.023 1.00 1.00 H +ATOM 591 P G A 19 -9.939 7.510 11.223 1.00 1.00 P +ATOM 592 OP1 G A 19 -9.631 7.288 12.652 1.00 1.00 O +ATOM 593 OP2 G A 19 -11.106 8.335 10.837 1.00 1.00 O +ATOM 594 O5' G A 19 -8.630 8.127 10.515 1.00 1.00 O +ATOM 595 C5' G A 19 -7.358 7.490 10.665 1.00 1.00 C +ATOM 596 C4' G A 19 -6.298 8.124 9.769 1.00 1.00 C +ATOM 597 O4' G A 19 -6.633 7.941 8.400 1.00 1.00 O +ATOM 598 C3' G A 19 -6.125 9.618 9.964 1.00 1.00 C +ATOM 599 O3' G A 19 -5.171 9.850 11.009 1.00 1.00 O +ATOM 600 C2' G A 19 -5.571 10.083 8.621 1.00 1.00 C +ATOM 601 O2' G A 19 -4.141 10.150 8.645 1.00 1.00 O +ATOM 602 C1' G A 19 -6.066 9.015 7.636 1.00 1.00 C +ATOM 603 N9 G A 19 -7.104 9.488 6.702 1.00 1.00 N +ATOM 604 C8 G A 19 -8.456 9.599 6.900 1.00 1.00 C +ATOM 605 N7 G A 19 -9.109 10.035 5.859 1.00 1.00 N +ATOM 606 C5 G A 19 -8.120 10.228 4.899 1.00 1.00 C +ATOM 607 C6 G A 19 -8.231 10.694 3.559 1.00 1.00 C +ATOM 608 O6 G A 19 -9.243 11.032 2.950 1.00 1.00 O +ATOM 609 N1 G A 19 -6.992 10.743 2.934 1.00 1.00 N +ATOM 610 C2 G A 19 -5.795 10.388 3.520 1.00 1.00 C +ATOM 611 N2 G A 19 -4.709 10.503 2.757 1.00 1.00 N +ATOM 612 N3 G A 19 -5.689 9.950 4.779 1.00 1.00 N +ATOM 613 C4 G A 19 -6.888 9.896 5.406 1.00 1.00 C +ATOM 614 H5' G A 19 -7.456 6.436 10.407 1.00 1.00 H +ATOM 615 H5'' G A 19 -7.040 7.573 11.704 1.00 1.00 H +ATOM 616 H4' G A 19 -5.343 7.634 9.954 1.00 1.00 H +ATOM 617 H3' G A 19 -7.082 10.099 10.181 1.00 1.00 H +ATOM 618 H2' G A 19 -6.000 11.053 8.360 1.00 1.00 H +ATOM 619 HO2' G A 19 -3.890 10.594 9.458 1.00 1.00 H +ATOM 620 H1' G A 19 -5.222 8.635 7.059 1.00 1.00 H +ATOM 621 H8 G A 19 -8.941 9.345 7.843 1.00 1.00 H +ATOM 622 H1 G A 19 -6.990 11.065 1.977 1.00 1.00 H +ATOM 623 H21 G A 19 -4.791 10.835 1.807 1.00 1.00 H +ATOM 624 H22 G A 19 -3.802 10.259 3.130 1.00 1.00 H +ATOM 625 P G A 20 -5.305 11.123 11.985 1.00 1.00 P +ATOM 626 OP1 G A 20 -4.368 10.939 13.116 1.00 1.00 O +ATOM 627 OP2 G A 20 -6.743 11.357 12.249 1.00 1.00 O +ATOM 628 O5' G A 20 -4.758 12.327 11.072 1.00 1.00 O +ATOM 629 C5' G A 20 -5.384 13.609 11.113 1.00 1.00 C +ATOM 630 C4' G A 20 -5.039 14.434 9.881 1.00 1.00 C +ATOM 631 O4' G A 20 -5.223 13.642 8.706 1.00 1.00 O +ATOM 632 C3' G A 20 -5.891 15.684 9.723 1.00 1.00 C +ATOM 633 O3' G A 20 -5.190 16.808 10.263 1.00 1.00 O +ATOM 634 C2' G A 20 -6.029 15.839 8.217 1.00 1.00 C +ATOM 635 O2' G A 20 -5.001 16.683 7.686 1.00 1.00 O +ATOM 636 C1' G A 20 -5.895 14.410 7.701 1.00 1.00 C +ATOM 637 N9 G A 20 -7.182 13.748 7.432 1.00 1.00 N +ATOM 638 C8 G A 20 -8.042 13.147 8.315 1.00 1.00 C +ATOM 639 N7 G A 20 -9.112 12.654 7.760 1.00 1.00 N +ATOM 640 C5 G A 20 -8.955 12.946 6.409 1.00 1.00 C +ATOM 641 C6 G A 20 -9.810 12.653 5.310 1.00 1.00 C +ATOM 642 O6 G A 20 -10.892 12.072 5.320 1.00 1.00 O +ATOM 643 N1 G A 20 -9.282 13.122 4.116 1.00 1.00 N +ATOM 644 C2 G A 20 -8.083 13.789 3.988 1.00 1.00 C +ATOM 645 N2 G A 20 -7.746 14.157 2.752 1.00 1.00 N +ATOM 646 N3 G A 20 -7.275 14.067 5.019 1.00 1.00 N +ATOM 647 C4 G A 20 -7.776 13.617 6.196 1.00 1.00 C +ATOM 648 H5' G A 20 -5.048 14.142 12.003 1.00 1.00 H +ATOM 649 H5'' G A 20 -6.464 13.476 11.164 1.00 1.00 H +ATOM 650 H4' G A 20 -3.993 14.727 9.936 1.00 1.00 H +ATOM 651 H3' G A 20 -6.867 15.557 10.194 1.00 1.00 H +ATOM 652 H2' G A 20 -7.018 16.233 7.971 1.00 1.00 H +ATOM 653 HO2' G A 20 -4.769 16.339 6.820 1.00 1.00 H +ATOM 654 H1' G A 20 -5.299 14.408 6.788 1.00 1.00 H +ATOM 655 H8 G A 20 -7.846 13.085 9.385 1.00 1.00 H +ATOM 656 H1 G A 20 -9.835 12.950 3.288 1.00 1.00 H +ATOM 657 H21 G A 20 -8.356 13.945 1.976 1.00 1.00 H +ATOM 658 H22 G A 20 -6.881 14.646 2.593 1.00 1.00 H +ATOM 659 P A A 21 -5.908 17.789 11.321 1.00 1.00 P +ATOM 660 OP1 A A 21 -4.862 18.406 12.165 1.00 1.00 O +ATOM 661 OP2 A A 21 -7.027 17.051 11.950 1.00 1.00 O +ATOM 662 O5' A A 21 -6.526 18.930 10.369 1.00 1.00 O +ATOM 663 C5' A A 21 -7.539 19.813 10.855 1.00 1.00 C +ATOM 664 C4' A A 21 -7.993 20.785 9.771 1.00 1.00 C +ATOM 665 O4' A A 21 -6.934 21.707 9.487 1.00 1.00 O +ATOM 666 C3' A A 21 -8.381 20.098 8.461 1.00 1.00 C +ATOM 667 O3' A A 21 -9.803 20.136 8.303 1.00 1.00 O +ATOM 668 C2' A A 21 -7.731 20.941 7.374 1.00 1.00 C +ATOM 669 O2' A A 21 -8.661 21.876 6.815 1.00 1.00 O +ATOM 670 C1' A A 21 -6.598 21.654 8.098 1.00 1.00 C +ATOM 671 N9 A A 21 -5.292 20.979 7.977 1.00 1.00 N +ATOM 672 C8 A A 21 -4.700 20.092 8.838 1.00 1.00 C +ATOM 673 N7 A A 21 -3.531 19.672 8.440 1.00 1.00 N +ATOM 674 C5 A A 21 -3.335 20.328 7.229 1.00 1.00 C +ATOM 675 C6 A A 21 -2.284 20.312 6.297 1.00 1.00 C +ATOM 676 N6 A A 21 -1.182 19.576 6.452 1.00 1.00 N +ATOM 677 N1 A A 21 -2.416 21.082 5.206 1.00 1.00 N +ATOM 678 C2 A A 21 -3.516 21.811 5.056 1.00 1.00 C +ATOM 679 N3 A A 21 -4.567 21.910 5.854 1.00 1.00 N +ATOM 680 C4 A A 21 -4.404 21.127 6.940 1.00 1.00 C +ATOM 681 H5' A A 21 -7.143 20.379 11.697 1.00 1.00 H +ATOM 682 H5'' A A 21 -8.394 19.225 11.190 1.00 1.00 H +ATOM 683 H4' A A 21 -8.849 21.347 10.140 1.00 1.00 H +ATOM 684 H3' A A 21 -8.007 19.072 8.433 1.00 1.00 H +ATOM 685 H2' A A 21 -7.323 20.293 6.595 1.00 1.00 H +ATOM 686 HO2' A A 21 -8.345 22.756 7.030 1.00 1.00 H +ATOM 687 H1' A A 21 -6.511 22.669 7.712 1.00 1.00 H +ATOM 688 H8 A A 21 -5.164 19.769 9.770 1.00 1.00 H +ATOM 689 H61 A A 21 -0.454 19.601 5.751 1.00 1.00 H +ATOM 690 H62 A A 21 -1.074 18.994 7.270 1.00 1.00 H +ATOM 691 H2 A A 21 -3.558 22.413 4.148 1.00 1.00 H +ATOM 692 P A A 22 -10.501 19.382 7.064 1.00 1.00 P +ATOM 693 OP1 A A 22 -11.332 20.363 6.330 1.00 1.00 O +ATOM 694 OP2 A A 22 -11.107 18.129 7.566 1.00 1.00 O +ATOM 695 O5' A A 22 -9.238 19.000 6.143 1.00 1.00 O +ATOM 696 C5' A A 22 -9.388 18.816 4.733 1.00 1.00 C +ATOM 697 C4' A A 22 -8.667 19.914 3.949 1.00 1.00 C +ATOM 698 O4' A A 22 -7.497 20.315 4.667 1.00 1.00 O +ATOM 699 C3' A A 22 -8.232 19.504 2.542 1.00 1.00 C +ATOM 700 O3' A A 22 -9.130 20.067 1.579 1.00 1.00 O +ATOM 701 C2' A A 22 -6.856 20.131 2.382 1.00 1.00 C +ATOM 702 O2' A A 22 -6.941 21.420 1.764 1.00 1.00 O +ATOM 703 C1' A A 22 -6.353 20.235 3.813 1.00 1.00 C +ATOM 704 N9 A A 22 -5.556 19.078 4.255 1.00 1.00 N +ATOM 705 C8 A A 22 -5.847 18.164 5.235 1.00 1.00 C +ATOM 706 N7 A A 22 -4.921 17.260 5.406 1.00 1.00 N +ATOM 707 C5 A A 22 -3.948 17.600 4.471 1.00 1.00 C +ATOM 708 C6 A A 22 -2.706 17.031 4.145 1.00 1.00 C +ATOM 709 N6 A A 22 -2.216 15.951 4.754 1.00 1.00 N +ATOM 710 N1 A A 22 -1.995 17.621 3.168 1.00 1.00 N +ATOM 711 C2 A A 22 -2.490 18.696 2.566 1.00 1.00 C +ATOM 712 N3 A A 22 -3.638 19.320 2.782 1.00 1.00 N +ATOM 713 C4 A A 22 -4.327 18.706 3.766 1.00 1.00 C +ATOM 714 H5' A A 22 -10.448 18.837 4.480 1.00 1.00 H +ATOM 715 H5'' A A 22 -8.975 17.847 4.459 1.00 1.00 H +ATOM 716 H4' A A 22 -9.327 20.776 3.871 1.00 1.00 H +ATOM 717 H3' A A 22 -8.177 18.419 2.447 1.00 1.00 H +ATOM 718 H2' A A 22 -6.207 19.467 1.805 1.00 1.00 H +ATOM 719 HO2' A A 22 -7.873 21.639 1.687 1.00 1.00 H +ATOM 720 H1' A A 22 -5.757 21.140 3.923 1.00 1.00 H +ATOM 721 H8 A A 22 -6.768 18.189 5.818 1.00 1.00 H +ATOM 722 H61 A A 22 -1.316 15.581 4.480 1.00 1.00 H +ATOM 723 H62 A A 22 -2.744 15.501 5.488 1.00 1.00 H +ATOM 724 H2 A A 22 -1.864 19.123 1.784 1.00 1.00 H +ATOM 725 P A A 23 -9.667 19.184 0.342 1.00 1.00 P +ATOM 726 OP1 A A 23 -10.491 20.055 -0.525 1.00 1.00 O +ATOM 727 OP2 A A 23 -10.238 17.930 0.884 1.00 1.00 O +ATOM 728 O5' A A 23 -8.315 18.818 -0.452 1.00 1.00 O +ATOM 729 C5' A A 23 -7.738 19.743 -1.378 1.00 1.00 C +ATOM 730 C4' A A 23 -6.431 19.210 -1.957 1.00 1.00 C +ATOM 731 O4' A A 23 -5.446 19.133 -0.925 1.00 1.00 O +ATOM 732 C3' A A 23 -6.547 17.821 -2.572 1.00 1.00 C +ATOM 733 O3' A A 23 -6.750 17.935 -3.985 1.00 1.00 O +ATOM 734 C2' A A 23 -5.193 17.192 -2.295 1.00 1.00 C +ATOM 735 O2' A A 23 -4.277 17.423 -3.371 1.00 1.00 O +ATOM 736 C1' A A 23 -4.740 17.890 -1.019 1.00 1.00 C +ATOM 737 N9 A A 23 -5.027 17.125 0.207 1.00 1.00 N +ATOM 738 C8 A A 23 -6.198 17.042 0.914 1.00 1.00 C +ATOM 739 N7 A A 23 -6.131 16.259 1.956 1.00 1.00 N +ATOM 740 C5 A A 23 -4.819 15.792 1.939 1.00 1.00 C +ATOM 741 C6 A A 23 -4.109 14.918 2.780 1.00 1.00 C +ATOM 742 N6 A A 23 -4.648 14.332 3.850 1.00 1.00 N +ATOM 743 N1 A A 23 -2.825 14.675 2.470 1.00 1.00 N +ATOM 744 C2 A A 23 -2.293 15.259 1.403 1.00 1.00 C +ATOM 745 N3 A A 23 -2.854 16.091 0.540 1.00 1.00 N +ATOM 746 C4 A A 23 -4.140 16.316 0.876 1.00 1.00 C +ATOM 747 H5' A A 23 -7.542 20.685 -0.866 1.00 1.00 H +ATOM 748 H5'' A A 23 -8.441 19.919 -2.192 1.00 1.00 H +ATOM 749 H4' A A 23 -6.076 19.902 -2.718 1.00 1.00 H +ATOM 750 H3' A A 23 -7.347 17.250 -2.099 1.00 1.00 H +ATOM 751 H2' A A 23 -5.311 16.120 -2.111 1.00 1.00 H +ATOM 752 HO2' A A 23 -4.523 18.256 -3.779 1.00 1.00 H +ATOM 753 H1' A A 23 -3.670 18.085 -1.075 1.00 1.00 H +ATOM 754 H8 A A 23 -7.103 17.580 0.632 1.00 1.00 H +ATOM 755 H61 A A 23 -4.089 13.713 4.419 1.00 1.00 H +ATOM 756 H62 A A 23 -5.616 14.508 4.093 1.00 1.00 H +ATOM 757 H2 A A 23 -1.249 15.016 1.211 1.00 1.00 H +ATOM 758 P C A 24 -7.496 16.767 -4.807 1.00 1.00 P +ATOM 759 OP1 C A 24 -7.402 17.086 -6.250 1.00 1.00 O +ATOM 760 OP2 C A 24 -8.820 16.539 -4.187 1.00 1.00 O +ATOM 761 O5' C A 24 -6.573 15.479 -4.516 1.00 1.00 O +ATOM 762 C5' C A 24 -5.196 15.469 -4.901 1.00 1.00 C +ATOM 763 C4' C A 24 -4.395 14.452 -4.093 1.00 1.00 C +ATOM 764 O4' C A 24 -4.631 14.653 -2.700 1.00 1.00 O +ATOM 765 C3' C A 24 -4.745 13.000 -4.385 1.00 1.00 C +ATOM 766 O3' C A 24 -3.885 12.491 -5.409 1.00 1.00 O +ATOM 767 C2' C A 24 -4.449 12.295 -3.073 1.00 1.00 C +ATOM 768 O2' C A 24 -3.105 11.804 -3.037 1.00 1.00 O +ATOM 769 C1' C A 24 -4.669 13.384 -2.031 1.00 1.00 C +ATOM 770 N1 C A 24 -5.967 13.281 -1.336 1.00 1.00 N +ATOM 771 C2 C A 24 -6.014 12.510 -0.184 1.00 1.00 C +ATOM 772 O2 C A 24 -5.000 11.944 0.218 1.00 1.00 O +ATOM 773 N3 C A 24 -7.202 12.404 0.474 1.00 1.00 N +ATOM 774 C4 C A 24 -8.297 13.028 0.020 1.00 1.00 C +ATOM 775 N4 C A 24 -9.445 12.903 0.688 1.00 1.00 N +ATOM 776 C5 C A 24 -8.253 13.823 -1.168 1.00 1.00 C +ATOM 777 C6 C A 24 -7.074 13.922 -1.811 1.00 1.00 C +ATOM 778 H5' C A 24 -4.775 16.462 -4.741 1.00 1.00 H +ATOM 779 H5'' C A 24 -5.125 15.219 -5.959 1.00 1.00 H +ATOM 780 H4' C A 24 -3.336 14.605 -4.286 1.00 1.00 H +ATOM 781 H3' C A 24 -5.797 12.896 -4.657 1.00 1.00 H +ATOM 782 H2' C A 24 -5.162 11.486 -2.916 1.00 1.00 H +ATOM 783 HO2' C A 24 -2.717 12.098 -2.210 1.00 1.00 H +ATOM 784 H1' C A 24 -3.866 13.343 -1.296 1.00 1.00 H +ATOM 785 H41 C A 24 -9.482 12.343 1.527 1.00 1.00 H +ATOM 786 H42 C A 24 -10.278 13.369 0.354 1.00 1.00 H +ATOM 787 H5 C A 24 -9.143 14.331 -1.540 1.00 1.00 H +ATOM 788 H6 C A 24 -7.002 14.521 -2.719 1.00 1.00 H +ATOM 789 P U A 25 -4.291 11.181 -6.254 1.00 1.00 P +ATOM 790 OP1 U A 25 -3.257 10.959 -7.288 1.00 1.00 O +ATOM 791 OP2 U A 25 -5.712 11.307 -6.648 1.00 1.00 O +ATOM 792 O5' U A 25 -4.173 10.001 -5.160 1.00 1.00 O +ATOM 793 C5' U A 25 -2.923 9.725 -4.521 1.00 1.00 C +ATOM 794 C4' U A 25 -3.081 8.735 -3.366 1.00 1.00 C +ATOM 795 O4' U A 25 -3.976 9.264 -2.391 1.00 1.00 O +ATOM 796 C3' U A 25 -3.645 7.381 -3.768 1.00 1.00 C +ATOM 797 O3' U A 25 -2.579 6.486 -4.106 1.00 1.00 O +ATOM 798 C2' U A 25 -4.343 6.897 -2.509 1.00 1.00 C +ATOM 799 O2' U A 25 -3.495 6.035 -1.741 1.00 1.00 O +ATOM 800 C1' U A 25 -4.666 8.181 -1.747 1.00 1.00 C +ATOM 801 N1 U A 25 -6.108 8.516 -1.728 1.00 1.00 N +ATOM 802 C2 U A 25 -6.853 8.096 -0.642 1.00 1.00 C +ATOM 803 O2 U A 25 -6.355 7.462 0.287 1.00 1.00 O +ATOM 804 N3 U A 25 -8.196 8.427 -0.660 1.00 1.00 N +ATOM 805 C4 U A 25 -8.849 9.135 -1.655 1.00 1.00 C +ATOM 806 O4 U A 25 -10.051 9.374 -1.568 1.00 1.00 O +ATOM 807 C5 U A 25 -7.993 9.533 -2.750 1.00 1.00 C +ATOM 808 C6 U A 25 -6.675 9.219 -2.755 1.00 1.00 C +ATOM 809 H5' U A 25 -2.510 10.657 -4.134 1.00 1.00 H +ATOM 810 H5'' U A 25 -2.232 9.310 -5.255 1.00 1.00 H +ATOM 811 H4' U A 25 -2.112 8.588 -2.895 1.00 1.00 H +ATOM 812 H3' U A 25 -4.354 7.483 -4.592 1.00 1.00 H +ATOM 813 H2' U A 25 -5.265 6.388 -2.776 1.00 1.00 H +ATOM 814 HO2' U A 25 -2.877 6.594 -1.266 1.00 1.00 H +ATOM 815 H1' U A 25 -4.306 8.089 -0.723 1.00 1.00 H +ATOM 816 H3 U A 25 -8.752 8.127 0.127 1.00 1.00 H +ATOM 817 H5 U A 25 -8.416 10.094 -3.585 1.00 1.00 H +ATOM 818 H6 U A 25 -6.054 9.532 -3.594 1.00 1.00 H +ATOM 819 P U A 26 -2.877 5.125 -4.919 1.00 1.00 P +ATOM 820 OP1 U A 26 -1.596 4.624 -5.466 1.00 1.00 O +ATOM 821 OP2 U A 26 -4.019 5.373 -5.829 1.00 1.00 O +ATOM 822 O5' U A 26 -3.366 4.110 -3.762 1.00 1.00 O +ATOM 823 C5' U A 26 -2.465 3.689 -2.732 1.00 1.00 C +ATOM 824 C4' U A 26 -3.194 3.002 -1.575 1.00 1.00 C +ATOM 825 O4' U A 26 -4.103 3.913 -0.953 1.00 1.00 O +ATOM 826 C3' U A 26 -4.022 1.791 -1.973 1.00 1.00 C +ATOM 827 O3' U A 26 -3.215 0.605 -1.925 1.00 1.00 O +ATOM 828 C2' U A 26 -5.091 1.739 -0.893 1.00 1.00 C +ATOM 829 O2' U A 26 -4.678 0.950 0.225 1.00 1.00 O +ATOM 830 C1' U A 26 -5.268 3.197 -0.500 1.00 1.00 C +ATOM 831 N1 U A 26 -6.449 3.823 -1.125 1.00 1.00 N +ATOM 832 C2 U A 26 -7.591 3.984 -0.364 1.00 1.00 C +ATOM 833 O2 U A 26 -7.659 3.606 0.803 1.00 1.00 O +ATOM 834 N3 U A 26 -8.661 4.594 -0.996 1.00 1.00 N +ATOM 835 C4 U A 26 -8.685 5.051 -2.303 1.00 1.00 C +ATOM 836 O4 U A 26 -9.693 5.582 -2.763 1.00 1.00 O +ATOM 837 C5 U A 26 -7.448 4.841 -3.023 1.00 1.00 C +ATOM 838 C6 U A 26 -6.388 4.245 -2.425 1.00 1.00 C +ATOM 839 H5' U A 26 -1.934 4.561 -2.350 1.00 1.00 H +ATOM 840 H5'' U A 26 -1.741 2.993 -3.157 1.00 1.00 H +ATOM 841 H4' U A 26 -2.461 2.696 -0.832 1.00 1.00 H +ATOM 842 H3' U A 26 -4.469 1.931 -2.958 1.00 1.00 H +ATOM 843 H2' U A 26 -6.022 1.365 -1.315 1.00 1.00 H +ATOM 844 HO2' U A 26 -5.243 1.187 0.964 1.00 1.00 H +ATOM 845 H1' U A 26 -5.342 3.276 0.584 1.00 1.00 H +ATOM 846 H3 U A 26 -9.503 4.719 -0.452 1.00 1.00 H +ATOM 847 H5 U A 26 -7.369 5.162 -4.061 1.00 1.00 H +ATOM 848 H6 U A 26 -5.467 4.101 -2.990 1.00 1.00 H +ATOM 849 P G A 27 -3.669 -0.734 -2.706 1.00 1.00 P +ATOM 850 OP1 G A 27 -2.609 -1.751 -2.534 1.00 1.00 O +ATOM 851 OP2 G A 27 -4.114 -0.351 -4.065 1.00 1.00 O +ATOM 852 O5' G A 27 -4.961 -1.198 -1.864 1.00 1.00 O +ATOM 853 C5' G A 27 -4.837 -1.474 -0.469 1.00 1.00 C +ATOM 854 C4' G A 27 -6.178 -1.367 0.247 1.00 1.00 C +ATOM 855 O4' G A 27 -6.798 -0.126 -0.081 1.00 1.00 O +ATOM 856 C3' G A 27 -7.189 -2.445 -0.109 1.00 1.00 C +ATOM 857 O3' G A 27 -7.033 -3.559 0.781 1.00 1.00 O +ATOM 858 C2' G A 27 -8.523 -1.769 0.163 1.00 1.00 C +ATOM 859 O2' G A 27 -9.025 -2.117 1.458 1.00 1.00 O +ATOM 860 C1' G A 27 -8.212 -0.275 0.071 1.00 1.00 C +ATOM 861 N9 G A 27 -8.900 0.419 -1.034 1.00 1.00 N +ATOM 862 C8 G A 27 -8.473 0.685 -2.310 1.00 1.00 C +ATOM 863 N7 G A 27 -9.332 1.360 -3.023 1.00 1.00 N +ATOM 864 C5 G A 27 -10.405 1.556 -2.159 1.00 1.00 C +ATOM 865 C6 G A 27 -11.640 2.229 -2.374 1.00 1.00 C +ATOM 866 O6 G A 27 -12.032 2.800 -3.390 1.00 1.00 O +ATOM 867 N1 G A 27 -12.443 2.194 -1.242 1.00 1.00 N +ATOM 868 C2 G A 27 -12.104 1.587 -0.051 1.00 1.00 C +ATOM 869 N2 G A 27 -13.010 1.652 0.923 1.00 1.00 N +ATOM 870 N3 G A 27 -10.945 0.957 0.153 1.00 1.00 N +ATOM 871 C4 G A 27 -10.149 0.982 -0.940 1.00 1.00 C +ATOM 872 H5' G A 27 -4.142 -0.763 -0.027 1.00 1.00 H +ATOM 873 H5'' G A 27 -4.445 -2.484 -0.339 1.00 1.00 H +ATOM 874 H4' G A 27 -6.005 -1.385 1.320 1.00 1.00 H +ATOM 875 H3' G A 27 -7.101 -2.745 -1.154 1.00 1.00 H +ATOM 876 H2' G A 27 -9.243 -2.043 -0.612 1.00 1.00 H +ATOM 877 HO2' G A 27 -8.988 -1.326 1.999 1.00 1.00 H +ATOM 878 H1' G A 27 -8.505 0.200 1.005 1.00 1.00 H +ATOM 879 H8 G A 27 -7.508 0.355 -2.696 1.00 1.00 H +ATOM 880 H1 G A 27 -13.339 2.653 -1.318 1.00 1.00 H +ATOM 881 H21 G A 27 -13.889 2.130 0.767 1.00 1.00 H +ATOM 882 H22 G A 27 -12.818 1.227 1.819 1.00 1.00 H +ATOM 883 P G A 28 -7.801 -4.951 0.507 1.00 1.00 P +ATOM 884 OP1 G A 28 -7.090 -6.018 1.246 1.00 1.00 O +ATOM 885 OP2 G A 28 -8.015 -5.081 -0.951 1.00 1.00 O +ATOM 886 O5' G A 28 -9.237 -4.726 1.211 1.00 1.00 O +ATOM 887 C5' G A 28 -9.403 -4.919 2.622 1.00 1.00 C +ATOM 888 C4' G A 28 -10.869 -5.163 2.990 1.00 1.00 C +ATOM 889 O4' G A 28 -11.533 -3.920 3.244 1.00 1.00 O +ATOM 890 C3' G A 28 -11.659 -5.885 1.908 1.00 1.00 C +ATOM 891 O3' G A 28 -11.673 -7.290 2.181 1.00 1.00 O +ATOM 892 C2' G A 28 -13.059 -5.308 2.041 1.00 1.00 C +ATOM 893 O2' G A 28 -13.856 -6.076 2.948 1.00 1.00 O +ATOM 894 C1' G A 28 -12.802 -3.904 2.572 1.00 1.00 C +ATOM 895 N9 G A 28 -12.716 -2.881 1.520 1.00 1.00 N +ATOM 896 C8 G A 28 -11.592 -2.258 1.041 1.00 1.00 C +ATOM 897 N7 G A 28 -11.826 -1.403 0.086 1.00 1.00 N +ATOM 898 C5 G A 28 -13.206 -1.460 -0.085 1.00 1.00 C +ATOM 899 C6 G A 28 -14.040 -0.748 -0.990 1.00 1.00 C +ATOM 900 O6 G A 28 -13.716 0.085 -1.835 1.00 1.00 O +ATOM 901 N1 G A 28 -15.373 -1.100 -0.836 1.00 1.00 N +ATOM 902 C2 G A 28 -15.849 -2.021 0.072 1.00 1.00 C +ATOM 903 N2 G A 28 -17.165 -2.224 0.068 1.00 1.00 N +ATOM 904 N3 G A 28 -15.067 -2.691 0.925 1.00 1.00 N +ATOM 905 C4 G A 28 -13.760 -2.362 0.789 1.00 1.00 C +ATOM 906 H5' G A 28 -9.048 -4.030 3.145 1.00 1.00 H +ATOM 907 H5'' G A 28 -8.810 -5.777 2.935 1.00 1.00 H +ATOM 908 H4' G A 28 -10.901 -5.760 3.900 1.00 1.00 H +ATOM 909 H3' G A 28 -11.244 -5.676 0.921 1.00 1.00 H +ATOM 910 H2' G A 28 -13.533 -5.251 1.059 1.00 1.00 H +ATOM 911 HO2' G A 28 -13.314 -6.806 3.258 1.00 1.00 H +ATOM 912 H1' G A 28 -13.586 -3.633 3.276 1.00 1.00 H +ATOM 913 H8 G A 28 -10.593 -2.456 1.429 1.00 1.00 H +ATOM 914 H1 G A 28 -16.029 -0.634 -1.447 1.00 1.00 H +ATOM 915 H21 G A 28 -17.757 -1.711 -0.582 1.00 1.00 H +ATOM 916 H22 G A 28 -17.577 -2.887 0.710 1.00 1.00 H +ATOM 917 P U A 29 -11.697 -8.357 0.973 1.00 1.00 P +ATOM 918 OP1 U A 29 -11.471 -9.702 1.544 1.00 1.00 O +ATOM 919 OP2 U A 29 -10.815 -7.855 -0.105 1.00 1.00 O +ATOM 920 O5' U A 29 -13.221 -8.281 0.457 1.00 1.00 O +ATOM 921 C5' U A 29 -14.289 -8.738 1.292 1.00 1.00 C +ATOM 922 C4' U A 29 -15.652 -8.545 0.628 1.00 1.00 C +ATOM 923 O4' U A 29 -15.930 -7.150 0.498 1.00 1.00 O +ATOM 924 C3' U A 29 -15.764 -9.150 -0.764 1.00 1.00 C +ATOM 925 O3' U A 29 -16.296 -10.477 -0.671 1.00 1.00 O +ATOM 926 C2' U A 29 -16.761 -8.237 -1.457 1.00 1.00 C +ATOM 927 O2' U A 29 -18.106 -8.684 -1.257 1.00 1.00 O +ATOM 928 C1' U A 29 -16.517 -6.892 -0.787 1.00 1.00 C +ATOM 929 N1 U A 29 -15.590 -6.017 -1.531 1.00 1.00 N +ATOM 930 C2 U A 29 -16.130 -5.143 -2.454 1.00 1.00 C +ATOM 931 O2 U A 29 -17.340 -5.078 -2.665 1.00 1.00 O +ATOM 932 N3 U A 29 -15.229 -4.339 -3.129 1.00 1.00 N +ATOM 933 C4 U A 29 -13.854 -4.336 -2.964 1.00 1.00 C +ATOM 934 O4 U A 29 -13.146 -3.576 -3.621 1.00 1.00 O +ATOM 935 C5 U A 29 -13.378 -5.282 -1.980 1.00 1.00 C +ATOM 936 C6 U A 29 -14.242 -6.080 -1.306 1.00 1.00 C +ATOM 937 H5' U A 29 -14.269 -8.183 2.230 1.00 1.00 H +ATOM 938 H5'' U A 29 -14.147 -9.797 1.503 1.00 1.00 H +ATOM 939 H4' U A 29 -16.415 -8.987 1.263 1.00 1.00 H +ATOM 940 H3' U A 29 -14.799 -9.140 -1.276 1.00 1.00 H +ATOM 941 H2' U A 29 -16.528 -8.170 -2.520 1.00 1.00 H +ATOM 942 HO2' U A 29 -18.683 -8.040 -1.674 1.00 1.00 H +ATOM 943 H1' U A 29 -17.468 -6.378 -0.653 1.00 1.00 H +ATOM 944 H3 U A 29 -15.609 -3.694 -3.806 1.00 1.00 H +ATOM 945 H5 U A 29 -12.309 -5.356 -1.777 1.00 1.00 H +ATOM 946 H6 U A 29 -13.855 -6.784 -0.569 1.00 1.00 H +ATOM 947 P U A 30 -15.839 -11.624 -1.708 1.00 1.00 P +ATOM 948 OP1 U A 30 -16.455 -12.898 -1.282 1.00 1.00 O +ATOM 949 OP2 U A 30 -14.371 -11.536 -1.876 1.00 1.00 O +ATOM 950 O5' U A 30 -16.530 -11.168 -3.090 1.00 1.00 O +ATOM 951 C5' U A 30 -17.921 -11.411 -3.325 1.00 1.00 C +ATOM 952 C4' U A 30 -18.358 -10.899 -4.696 1.00 1.00 C +ATOM 953 O4' U A 30 -18.212 -9.480 -4.752 1.00 1.00 O +ATOM 954 C3' U A 30 -17.558 -11.461 -5.862 1.00 1.00 C +ATOM 955 O3' U A 30 -18.169 -12.664 -6.341 1.00 1.00 O +ATOM 956 C2' U A 30 -17.672 -10.362 -6.901 1.00 1.00 C +ATOM 957 O2' U A 30 -18.862 -10.503 -7.685 1.00 1.00 O +ATOM 958 C1' U A 30 -17.715 -9.101 -6.044 1.00 1.00 C +ATOM 959 N1 U A 30 -16.396 -8.464 -5.844 1.00 1.00 N +ATOM 960 C2 U A 30 -16.033 -7.459 -6.720 1.00 1.00 C +ATOM 961 O2 U A 30 -16.755 -7.113 -7.654 1.00 1.00 O +ATOM 962 N3 U A 30 -14.807 -6.864 -6.486 1.00 1.00 N +ATOM 963 C4 U A 30 -13.925 -7.182 -5.467 1.00 1.00 C +ATOM 964 O4 U A 30 -12.858 -6.582 -5.352 1.00 1.00 O +ATOM 965 C5 U A 30 -14.387 -8.242 -4.599 1.00 1.00 C +ATOM 966 C6 U A 30 -15.585 -8.841 -4.809 1.00 1.00 C +ATOM 967 H5' U A 30 -18.506 -10.907 -2.554 1.00 1.00 H +ATOM 968 H5'' U A 30 -18.111 -12.483 -3.272 1.00 1.00 H +ATOM 969 H4' U A 30 -19.408 -11.140 -4.843 1.00 1.00 H +ATOM 970 H3' U A 30 -16.516 -11.626 -5.577 1.00 1.00 H +ATOM 971 H2' U A 30 -16.788 -10.352 -7.538 1.00 1.00 H +ATOM 972 HO2' U A 30 -18.780 -9.907 -8.433 1.00 1.00 H +ATOM 973 H1' U A 30 -18.396 -8.381 -6.495 1.00 1.00 H +ATOM 974 H3 U A 30 -14.529 -6.127 -7.118 1.00 1.00 H +ATOM 975 H5 U A 30 -13.762 -8.566 -3.767 1.00 1.00 H +ATOM 976 H6 U A 30 -15.908 -9.638 -4.138 1.00 1.00 H +ATOM 977 P C A 31 -17.284 -13.821 -7.032 1.00 1.00 P +ATOM 978 OP1 C A 31 -18.199 -14.887 -7.495 1.00 1.00 O +ATOM 979 OP2 C A 31 -16.165 -14.154 -6.122 1.00 1.00 O +ATOM 980 O5' C A 31 -16.675 -13.087 -8.331 1.00 1.00 O +ATOM 981 C5' C A 31 -17.524 -12.719 -9.419 1.00 1.00 C +ATOM 982 C4' C A 31 -16.800 -11.831 -10.426 1.00 1.00 C +ATOM 983 O4' C A 31 -16.444 -10.592 -9.825 1.00 1.00 O +ATOM 984 C3' C A 31 -15.501 -12.401 -10.962 1.00 1.00 C +ATOM 985 O3' C A 31 -15.762 -13.287 -12.058 1.00 1.00 O +ATOM 986 C2' C A 31 -14.783 -11.154 -11.452 1.00 1.00 C +ATOM 987 O2' C A 31 -15.083 -10.881 -12.826 1.00 1.00 O +ATOM 988 C1' C A 31 -15.320 -10.053 -10.535 1.00 1.00 C +ATOM 989 N1 C A 31 -14.335 -9.569 -9.540 1.00 1.00 N +ATOM 990 C2 C A 31 -13.618 -8.429 -9.868 1.00 1.00 C +ATOM 991 O2 C A 31 -13.785 -7.891 -10.960 1.00 1.00 O +ATOM 992 N3 C A 31 -12.738 -7.934 -8.955 1.00 1.00 N +ATOM 993 C4 C A 31 -12.568 -8.533 -7.768 1.00 1.00 C +ATOM 994 N4 C A 31 -11.698 -8.021 -6.898 1.00 1.00 N +ATOM 995 C5 C A 31 -13.306 -9.709 -7.425 1.00 1.00 C +ATOM 996 C6 C A 31 -14.176 -10.191 -8.335 1.00 1.00 C +ATOM 997 H5' C A 31 -18.388 -12.182 -9.029 1.00 1.00 H +ATOM 998 H5'' C A 31 -17.868 -13.622 -9.924 1.00 1.00 H +ATOM 999 H4' C A 31 -17.467 -11.627 -11.259 1.00 1.00 H +ATOM 1000 H3' C A 31 -14.933 -12.896 -10.171 1.00 1.00 H +ATOM 1001 H2' C A 31 -13.716 -11.259 -11.306 1.00 1.00 H +ATOM 1002 HO2' C A 31 -14.659 -10.050 -13.050 1.00 1.00 H +ATOM 1003 H1' C A 31 -15.657 -9.210 -11.142 1.00 1.00 H +ATOM 1004 H41 C A 31 -11.177 -7.198 -7.131 1.00 1.00 H +ATOM 1005 H42 C A 31 -11.562 -8.466 -5.998 1.00 1.00 H +ATOM 1006 H5 C A 31 -13.171 -10.198 -6.459 1.00 1.00 H +ATOM 1007 H6 C A 31 -14.757 -11.085 -8.107 1.00 1.00 H +ATOM 1008 P U A 32 -14.981 -14.693 -12.183 1.00 1.00 P +ATOM 1009 OP1 U A 32 -15.843 -15.635 -12.930 1.00 1.00 O +ATOM 1010 OP2 U A 32 -14.478 -15.059 -10.839 1.00 1.00 O +ATOM 1011 O5' U A 32 -13.712 -14.319 -13.105 1.00 1.00 O +ATOM 1012 C5' U A 32 -13.898 -13.592 -14.321 1.00 1.00 C +ATOM 1013 C4' U A 32 -12.802 -12.548 -14.534 1.00 1.00 C +ATOM 1014 O4' U A 32 -12.743 -11.654 -13.429 1.00 1.00 O +ATOM 1015 C3' U A 32 -11.394 -13.102 -14.680 1.00 1.00 C +ATOM 1016 O3' U A 32 -11.156 -13.445 -16.052 1.00 1.00 O +ATOM 1017 C2' U A 32 -10.523 -11.915 -14.285 1.00 1.00 C +ATOM 1018 O2' U A 32 -10.083 -11.184 -15.433 1.00 1.00 O +ATOM 1019 C1' U A 32 -11.433 -11.067 -13.396 1.00 1.00 C +ATOM 1020 N1 U A 32 -10.987 -10.974 -11.984 1.00 1.00 N +ATOM 1021 C2 U A 32 -10.226 -9.875 -11.635 1.00 1.00 C +ATOM 1022 O2 U A 32 -9.905 -9.016 -12.454 1.00 1.00 O +ATOM 1023 N3 U A 32 -9.844 -9.797 -10.308 1.00 1.00 N +ATOM 1024 C4 U A 32 -10.153 -10.712 -9.314 1.00 1.00 C +ATOM 1025 O4 U A 32 -9.761 -10.541 -8.162 1.00 1.00 O +ATOM 1026 C5 U A 32 -10.951 -11.828 -9.769 1.00 1.00 C +ATOM 1027 C6 U A 32 -11.337 -11.926 -11.064 1.00 1.00 C +ATOM 1028 H5' U A 32 -14.864 -13.089 -14.285 1.00 1.00 H +ATOM 1029 H5'' U A 32 -13.895 -14.290 -15.158 1.00 1.00 H +ATOM 1030 H4' U A 32 -13.043 -11.970 -15.423 1.00 1.00 H +ATOM 1031 H3' U A 32 -11.230 -13.954 -14.015 1.00 1.00 H +ATOM 1032 H2' U A 32 -9.672 -12.262 -13.700 1.00 1.00 H +ATOM 1033 HO2' U A 32 -10.343 -10.270 -15.305 1.00 1.00 H +ATOM 1034 H1' U A 32 -11.494 -10.063 -13.818 1.00 1.00 H +ATOM 1035 H3 U A 32 -9.287 -8.998 -10.038 1.00 1.00 H +ATOM 1036 H5 U A 32 -11.244 -12.602 -9.061 1.00 1.00 H +ATOM 1037 H6 U A 32 -11.937 -12.778 -11.379 1.00 1.00 H +ATOM 1038 P U A 33 -9.995 -14.485 -16.466 1.00 1.00 P +ATOM 1039 OP1 U A 33 -10.144 -14.786 -17.907 1.00 1.00 O +ATOM 1040 OP2 U A 33 -9.992 -15.589 -15.480 1.00 1.00 O +ATOM 1041 O5' U A 33 -8.642 -13.627 -16.270 1.00 1.00 O +ATOM 1042 C5' U A 33 -8.340 -12.529 -17.140 1.00 1.00 C +ATOM 1043 C4' U A 33 -7.069 -11.796 -16.708 1.00 1.00 C +ATOM 1044 O4' U A 33 -7.260 -11.190 -15.438 1.00 1.00 O +ATOM 1045 C3' U A 33 -5.847 -12.685 -16.574 1.00 1.00 C +ATOM 1046 O3' U A 33 -5.159 -12.746 -17.827 1.00 1.00 O +ATOM 1047 C2' U A 33 -4.992 -11.965 -15.537 1.00 1.00 C +ATOM 1048 O2' U A 33 -4.011 -11.129 -16.158 1.00 1.00 O +ATOM 1049 C1' U A 33 -6.005 -11.138 -14.740 1.00 1.00 C +ATOM 1050 N1 U A 33 -6.248 -11.651 -13.377 1.00 1.00 N +ATOM 1051 C2 U A 33 -5.568 -11.063 -12.326 1.00 1.00 C +ATOM 1052 O2 U A 33 -4.773 -10.141 -12.495 1.00 1.00 O +ATOM 1053 N3 U A 33 -5.833 -11.576 -11.069 1.00 1.00 N +ATOM 1054 C4 U A 33 -6.708 -12.608 -10.775 1.00 1.00 C +ATOM 1055 O4 U A 33 -6.868 -12.985 -9.616 1.00 1.00 O +ATOM 1056 C5 U A 33 -7.375 -13.161 -11.933 1.00 1.00 C +ATOM 1057 C6 U A 33 -7.132 -12.675 -13.175 1.00 1.00 C +ATOM 1058 H5' U A 33 -9.175 -11.828 -17.129 1.00 1.00 H +ATOM 1059 H5'' U A 33 -8.205 -12.905 -18.153 1.00 1.00 H +ATOM 1060 H4' U A 33 -6.855 -11.013 -17.431 1.00 1.00 H +ATOM 1061 H3' U A 33 -6.127 -13.681 -16.224 1.00 1.00 H +ATOM 1062 H2' U A 33 -4.515 -12.697 -14.879 1.00 1.00 H +ATOM 1063 HO2' U A 33 -3.204 -11.207 -15.644 1.00 1.00 H +ATOM 1064 H1' U A 33 -5.665 -10.104 -14.685 1.00 1.00 H +ATOM 1065 H3 U A 33 -5.343 -11.157 -10.291 1.00 1.00 H +ATOM 1066 H5 U A 33 -8.084 -13.980 -11.805 1.00 1.00 H +ATOM 1067 H6 U A 33 -7.649 -13.111 -14.030 1.00 1.00 H +ATOM 1068 P C A 34 -4.166 -13.970 -18.157 1.00 1.00 P +ATOM 1069 OP1 C A 34 -3.504 -13.693 -19.450 1.00 1.00 O +ATOM 1070 OP2 C A 34 -4.909 -15.235 -17.963 1.00 1.00 O +ATOM 1071 O5' C A 34 -3.063 -13.849 -16.990 1.00 1.00 O +ATOM 1072 C5' C A 34 -2.553 -15.021 -16.347 1.00 1.00 C +ATOM 1073 C4' C A 34 -1.372 -14.693 -15.438 1.00 1.00 C +ATOM 1074 O4' C A 34 -1.805 -13.859 -14.367 1.00 1.00 O +ATOM 1075 C3' C A 34 -0.717 -15.913 -14.811 1.00 1.00 C +ATOM 1076 O3' C A 34 0.386 -16.334 -15.618 1.00 1.00 O +ATOM 1077 C2' C A 34 -0.207 -15.409 -13.469 1.00 1.00 C +ATOM 1078 O2' C A 34 1.176 -15.045 -13.542 1.00 1.00 O +ATOM 1079 C1' C A 34 -1.084 -14.193 -13.172 1.00 1.00 C +ATOM 1080 N1 C A 34 -2.079 -14.420 -12.106 1.00 1.00 N +ATOM 1081 C2 C A 34 -1.662 -14.254 -10.796 1.00 1.00 C +ATOM 1082 O2 C A 34 -0.500 -13.929 -10.556 1.00 1.00 O +ATOM 1083 N3 C A 34 -2.567 -14.458 -9.800 1.00 1.00 N +ATOM 1084 C4 C A 34 -3.829 -14.809 -10.079 1.00 1.00 C +ATOM 1085 N4 C A 34 -4.690 -15.000 -9.080 1.00 1.00 N +ATOM 1086 C5 C A 34 -4.263 -14.982 -11.431 1.00 1.00 C +ATOM 1087 C6 C A 34 -3.360 -14.778 -12.409 1.00 1.00 C +ATOM 1088 H5' C A 34 -2.230 -15.732 -17.108 1.00 1.00 H +ATOM 1089 H5'' C A 34 -3.346 -15.472 -15.750 1.00 1.00 H +ATOM 1090 H4' C A 34 -0.625 -14.151 -16.015 1.00 1.00 H +ATOM 1091 H3' C A 34 -1.442 -16.717 -14.676 1.00 1.00 H +ATOM 1092 H2' C A 34 -0.362 -16.174 -12.703 1.00 1.00 H +ATOM 1093 HO2' C A 34 1.233 -14.246 -14.070 1.00 1.00 H +ATOM 1094 H1' C A 34 -0.449 -13.355 -12.892 1.00 1.00 H +ATOM 1095 H41 C A 34 -4.389 -14.879 -8.123 1.00 1.00 H +ATOM 1096 H42 C A 34 -5.644 -15.266 -9.279 1.00 1.00 H +ATOM 1097 H5 C A 34 -5.289 -15.268 -11.662 1.00 1.00 H +ATOM 1098 H6 C A 34 -3.656 -14.900 -13.452 1.00 1.00 H +ATOM 1099 P C A 35 1.011 -17.807 -15.439 1.00 1.00 P +ATOM 1100 OP1 C A 35 2.077 -17.984 -16.450 1.00 1.00 O +ATOM 1101 OP2 C A 35 -0.104 -18.777 -15.364 1.00 1.00 O +ATOM 1102 O5' C A 35 1.702 -17.718 -13.988 1.00 1.00 O +ATOM 1103 C5' C A 35 1.759 -18.865 -13.135 1.00 1.00 C +ATOM 1104 C4' C A 35 2.606 -18.599 -11.893 1.00 1.00 C +ATOM 1105 O4' C A 35 2.032 -17.528 -11.142 1.00 1.00 O +ATOM 1106 C3' C A 35 2.721 -19.793 -10.955 1.00 1.00 C +ATOM 1107 O3' C A 35 3.934 -20.502 -11.224 1.00 1.00 O +ATOM 1108 C2' C A 35 2.793 -19.171 -9.569 1.00 1.00 C +ATOM 1109 O2' C A 35 4.150 -19.013 -9.141 1.00 1.00 O +ATOM 1110 C1' C A 35 2.106 -17.819 -9.740 1.00 1.00 C +ATOM 1111 N1 C A 35 0.732 -17.777 -9.207 1.00 1.00 N +ATOM 1112 C2 C A 35 0.583 -17.718 -7.830 1.00 1.00 C +ATOM 1113 O2 C A 35 1.575 -17.706 -7.104 1.00 1.00 O +ATOM 1114 N3 C A 35 -0.678 -17.674 -7.318 1.00 1.00 N +ATOM 1115 C4 C A 35 -1.748 -17.688 -8.125 1.00 1.00 C +ATOM 1116 N4 C A 35 -2.968 -17.645 -7.592 1.00 1.00 N +ATOM 1117 C5 C A 35 -1.598 -17.750 -9.547 1.00 1.00 C +ATOM 1118 C6 C A 35 -0.346 -17.793 -10.042 1.00 1.00 C +ATOM 1119 H5' C A 35 2.191 -19.699 -13.689 1.00 1.00 H +ATOM 1120 H5'' C A 35 0.748 -19.128 -12.827 1.00 1.00 H +ATOM 1121 H4' C A 35 3.604 -18.302 -12.207 1.00 1.00 H +ATOM 1122 H3' C A 35 1.850 -20.445 -11.045 1.00 1.00 H +ATOM 1123 H2' C A 35 2.235 -19.783 -8.858 1.00 1.00 H +ATOM 1124 HO2' C A 35 4.134 -18.521 -8.318 1.00 1.00 H +ATOM 1125 H1' C A 35 2.701 -17.052 -9.246 1.00 1.00 H +ATOM 1126 H41 C A 35 -3.081 -17.601 -6.587 1.00 1.00 H +ATOM 1127 H42 C A 35 -3.781 -17.655 -8.189 1.00 1.00 H +ATOM 1128 H5 C A 35 -2.467 -17.764 -10.205 1.00 1.00 H +ATOM 1129 H6 C A 35 -0.194 -17.841 -11.120 1.00 1.00 H +ATOM 1130 P U A 36 4.167 -21.977 -10.623 1.00 1.00 P +ATOM 1131 OP1 U A 36 5.457 -22.489 -11.139 1.00 1.00 O +ATOM 1132 OP2 U A 36 2.928 -22.762 -10.824 1.00 1.00 O +ATOM 1133 O5' U A 36 4.335 -21.694 -9.045 1.00 1.00 O +ATOM 1134 C5' U A 36 4.042 -22.718 -8.089 1.00 1.00 C +ATOM 1135 C4' U A 36 4.424 -22.295 -6.672 1.00 1.00 C +ATOM 1136 O4' U A 36 3.647 -21.165 -6.277 1.00 1.00 O +ATOM 1137 C3' U A 36 4.209 -23.379 -5.625 1.00 1.00 C +ATOM 1138 O3' U A 36 5.436 -24.085 -5.411 1.00 1.00 O +ATOM 1139 C2' U A 36 3.828 -22.609 -4.372 1.00 1.00 C +ATOM 1140 O2' U A 36 4.974 -22.343 -3.556 1.00 1.00 O +ATOM 1141 C1' U A 36 3.221 -21.318 -4.914 1.00 1.00 C +ATOM 1142 N1 U A 36 1.746 -21.302 -4.906 1.00 1.00 N +ATOM 1143 C2 U A 36 1.115 -21.307 -3.677 1.00 1.00 C +ATOM 1144 O2 U A 36 1.742 -21.318 -2.620 1.00 1.00 O +ATOM 1145 N3 U A 36 -0.269 -21.297 -3.705 1.00 1.00 N +ATOM 1146 C4 U A 36 -1.063 -21.283 -4.839 1.00 1.00 C +ATOM 1147 O4 U A 36 -2.288 -21.274 -4.747 1.00 1.00 O +ATOM 1148 C5 U A 36 -0.318 -21.280 -6.079 1.00 1.00 C +ATOM 1149 C6 U A 36 1.037 -21.290 -6.076 1.00 1.00 C +ATOM 1150 H5' U A 36 4.596 -23.618 -8.352 1.00 1.00 H +ATOM 1151 H5'' U A 36 2.975 -22.937 -8.118 1.00 1.00 H +ATOM 1152 H4' U A 36 5.473 -22.006 -6.665 1.00 1.00 H +ATOM 1153 H3' U A 36 3.407 -24.057 -5.925 1.00 1.00 H +ATOM 1154 H2' U A 36 3.075 -23.166 -3.809 1.00 1.00 H +ATOM 1155 HO2' U A 36 4.657 -21.963 -2.733 1.00 1.00 H +ATOM 1156 H1' U A 36 3.587 -20.476 -4.327 1.00 1.00 H +ATOM 1157 H3 U A 36 -0.744 -21.299 -2.814 1.00 1.00 H +ATOM 1158 H5 U A 36 -0.854 -21.269 -7.028 1.00 1.00 H +ATOM 1159 H6 U A 36 1.573 -21.288 -7.026 1.00 1.00 H +ATOM 1160 P A A 37 5.434 -25.647 -5.014 1.00 1.00 P +ATOM 1161 OP1 A A 37 6.836 -26.124 -5.010 1.00 1.00 O +ATOM 1162 OP2 A A 37 4.424 -26.335 -5.850 1.00 1.00 O +ATOM 1163 O5' A A 37 4.902 -25.631 -3.495 1.00 1.00 O +ATOM 1164 C5' A A 37 5.659 -24.985 -2.467 1.00 1.00 C +ATOM 1165 C4' A A 37 5.015 -25.169 -1.094 1.00 1.00 C +ATOM 1166 O4' A A 37 3.750 -24.501 -1.071 1.00 1.00 O +ATOM 1167 C3' A A 37 4.772 -26.624 -0.715 1.00 1.00 C +ATOM 1168 O3' A A 37 5.011 -26.797 0.686 1.00 1.00 O +ATOM 1169 C2' A A 37 3.298 -26.851 -1.013 1.00 1.00 C +ATOM 1170 O2' A A 37 2.705 -27.738 -0.058 1.00 1.00 O +ATOM 1171 C1' A A 37 2.693 -25.455 -0.921 1.00 1.00 C +ATOM 1172 N9 A A 37 1.688 -25.174 -1.964 1.00 1.00 N +ATOM 1173 C8 A A 37 1.777 -25.371 -3.318 1.00 1.00 C +ATOM 1174 N7 A A 37 0.707 -25.015 -3.974 1.00 1.00 N +ATOM 1175 C5 A A 37 -0.150 -24.548 -2.984 1.00 1.00 C +ATOM 1176 C6 A A 37 -1.453 -24.023 -3.027 1.00 1.00 C +ATOM 1177 N6 A A 37 -2.145 -23.877 -4.158 1.00 1.00 N +ATOM 1178 N1 A A 37 -2.009 -23.658 -1.860 1.00 1.00 N +ATOM 1179 C2 A A 37 -1.315 -23.807 -0.737 1.00 1.00 C +ATOM 1180 N3 A A 37 -0.093 -24.285 -0.568 1.00 1.00 N +ATOM 1181 C4 A A 37 0.438 -24.642 -1.755 1.00 1.00 C +ATOM 1182 H5' A A 37 5.726 -23.921 -2.690 1.00 1.00 H +ATOM 1183 H5'' A A 37 6.665 -25.409 -2.447 1.00 1.00 H +ATOM 1184 H4' A A 37 5.657 -24.713 -0.343 1.00 1.00 H +ATOM 1185 H3' A A 37 5.396 -27.292 -1.309 1.00 1.00 H +ATOM 1186 H2' A A 37 3.180 -27.241 -2.027 1.00 1.00 H +ATOM 1187 HO2' A A 37 3.038 -27.490 0.807 1.00 1.00 H +ATOM 1188 H1' A A 37 2.232 -25.329 0.057 1.00 1.00 H +ATOM 1189 H8 A A 37 2.661 -25.788 -3.802 1.00 1.00 H +ATOM 1190 H61 A A 37 -3.079 -23.494 -4.133 1.00 1.00 H +ATOM 1191 H62 A A 37 -1.734 -24.149 -5.039 1.00 1.00 H +ATOM 1192 H2 A A 37 -1.826 -23.491 0.173 1.00 1.00 H +ATOM 1193 P A A 38 5.343 -28.253 1.287 1.00 1.00 P +ATOM 1194 OP1 A A 38 6.683 -28.658 0.805 1.00 1.00 O +ATOM 1195 OP2 A A 38 4.177 -29.131 1.048 1.00 1.00 O +ATOM 1196 O5' A A 38 5.443 -27.966 2.868 1.00 1.00 O +ATOM 1197 C5' A A 38 6.647 -27.449 3.442 1.00 1.00 C +ATOM 1198 C4' A A 38 6.362 -26.621 4.692 1.00 1.00 C +ATOM 1199 O4' A A 38 6.052 -25.277 4.314 1.00 1.00 O +ATOM 1200 C3' A A 38 5.196 -27.146 5.521 1.00 1.00 C +ATOM 1201 O3' A A 38 5.695 -27.904 6.628 1.00 1.00 O +ATOM 1202 C2' A A 38 4.506 -25.893 6.033 1.00 1.00 C +ATOM 1203 O2' A A 38 4.974 -25.539 7.339 1.00 1.00 O +ATOM 1204 C1' A A 38 4.878 -24.832 5.004 1.00 1.00 C +ATOM 1205 N9 A A 38 3.835 -24.587 3.991 1.00 1.00 N +ATOM 1206 C8 A A 38 3.797 -24.991 2.682 1.00 1.00 C +ATOM 1207 N7 A A 38 2.724 -24.609 2.044 1.00 1.00 N +ATOM 1208 C5 A A 38 2.000 -23.904 3.000 1.00 1.00 C +ATOM 1209 C6 A A 38 0.764 -23.240 2.956 1.00 1.00 C +ATOM 1210 N6 A A 38 0.005 -23.180 1.861 1.00 1.00 N +ATOM 1211 N1 A A 38 0.344 -22.644 4.085 1.00 1.00 N +ATOM 1212 C2 A A 38 1.102 -22.708 5.172 1.00 1.00 C +ATOM 1213 N3 A A 38 2.277 -23.298 5.339 1.00 1.00 N +ATOM 1214 C4 A A 38 2.670 -23.886 4.190 1.00 1.00 C +ATOM 1215 H5' A A 38 7.149 -26.820 2.707 1.00 1.00 H +ATOM 1216 H5'' A A 38 7.301 -28.279 3.707 1.00 1.00 H +ATOM 1217 H4' A A 38 7.256 -26.607 5.314 1.00 1.00 H +ATOM 1218 H3' A A 38 4.518 -27.742 4.906 1.00 1.00 H +ATOM 1219 H2' A A 38 3.423 -26.042 6.038 1.00 1.00 H +ATOM 1220 HO2' A A 38 4.606 -24.677 7.550 1.00 1.00 H +ATOM 1221 H1' A A 38 5.098 -23.898 5.520 1.00 1.00 H +ATOM 1222 H8 A A 38 4.590 -25.576 2.216 1.00 1.00 H +ATOM 1223 H61 A A 38 -0.878 -22.689 1.885 1.00 1.00 H +ATOM 1224 H62 A A 38 0.313 -23.625 1.009 1.00 1.00 H +ATOM 1225 H2 A A 38 0.703 -22.203 6.052 1.00 1.00 H +ATOM 1226 P G A 39 4.686 -28.744 7.559 1.00 1.00 P +ATOM 1227 OP1 G A 39 5.434 -29.871 8.158 1.00 1.00 O +ATOM 1228 OP2 G A 39 3.450 -29.006 6.787 1.00 1.00 O +ATOM 1229 O5' G A 39 4.334 -27.694 8.729 1.00 1.00 O +ATOM 1230 C5' G A 39 3.055 -27.722 9.368 1.00 1.00 C +ATOM 1231 C4' G A 39 2.364 -26.365 9.293 1.00 1.00 C +ATOM 1232 O4' G A 39 2.484 -25.843 7.967 1.00 1.00 O +ATOM 1233 C3' G A 39 0.880 -26.410 9.639 1.00 1.00 C +ATOM 1234 O3' G A 39 0.691 -25.982 10.991 1.00 1.00 O +ATOM 1235 C2' G A 39 0.248 -25.406 8.689 1.00 1.00 C +ATOM 1236 O2' G A 39 0.139 -24.113 9.294 1.00 1.00 O +ATOM 1237 C1' G A 39 1.209 -25.382 7.506 1.00 1.00 C +ATOM 1238 N9 G A 39 0.802 -26.253 6.387 1.00 1.00 N +ATOM 1239 C8 G A 39 1.230 -27.520 6.087 1.00 1.00 C +ATOM 1240 N7 G A 39 0.673 -28.029 5.025 1.00 1.00 N +ATOM 1241 C5 G A 39 -0.189 -27.027 4.585 1.00 1.00 C +ATOM 1242 C6 G A 39 -1.066 -27.005 3.466 1.00 1.00 C +ATOM 1243 O6 G A 39 -1.257 -27.884 2.629 1.00 1.00 O +ATOM 1244 N1 G A 39 -1.756 -25.803 3.384 1.00 1.00 N +ATOM 1245 C2 G A 39 -1.620 -24.751 4.266 1.00 1.00 C +ATOM 1246 N2 G A 39 -2.369 -23.676 4.019 1.00 1.00 N +ATOM 1247 N3 G A 39 -0.798 -24.770 5.318 1.00 1.00 N +ATOM 1248 C4 G A 39 -0.115 -25.936 5.414 1.00 1.00 C +ATOM 1249 H5' G A 39 3.187 -27.997 10.415 1.00 1.00 H +ATOM 1250 H5'' G A 39 2.429 -28.470 8.880 1.00 1.00 H +ATOM 1251 H4' G A 39 2.863 -25.681 9.977 1.00 1.00 H +ATOM 1252 H3' G A 39 0.473 -27.410 9.478 1.00 1.00 H +ATOM 1253 H2' G A 39 -0.732 -25.765 8.365 1.00 1.00 H +ATOM 1254 HO2' G A 39 0.874 -23.585 8.975 1.00 1.00 H +ATOM 1255 H1' G A 39 1.306 -24.361 7.145 1.00 1.00 H +ATOM 1256 H8 G A 39 1.972 -28.054 6.682 1.00 1.00 H +ATOM 1257 H1 G A 39 -2.400 -25.713 2.611 1.00 1.00 H +ATOM 1258 H21 G A 39 -2.990 -23.665 3.224 1.00 1.00 H +ATOM 1259 H22 G A 39 -2.314 -22.873 4.630 1.00 1.00 H +ATOM 1260 P U A 40 -0.250 -26.821 11.994 1.00 1.00 P +ATOM 1261 OP1 U A 40 -0.304 -26.104 13.287 1.00 1.00 O +ATOM 1262 OP2 U A 40 0.180 -28.237 11.954 1.00 1.00 O +ATOM 1263 O5' U A 40 -1.697 -26.716 11.297 1.00 1.00 O +ATOM 1264 C5' U A 40 -2.528 -25.573 11.515 1.00 1.00 C +ATOM 1265 C4' U A 40 -3.831 -25.674 10.728 1.00 1.00 C +ATOM 1266 O4' U A 40 -3.557 -25.592 9.331 1.00 1.00 O +ATOM 1267 C3' U A 40 -4.590 -26.972 10.954 1.00 1.00 C +ATOM 1268 O3' U A 40 -5.549 -26.794 12.005 1.00 1.00 O +ATOM 1269 C2' U A 40 -5.304 -27.202 9.632 1.00 1.00 C +ATOM 1270 O2' U A 40 -6.616 -26.631 9.643 1.00 1.00 O +ATOM 1271 C1' U A 40 -4.405 -26.501 8.616 1.00 1.00 C +ATOM 1272 N1 U A 40 -3.528 -27.416 7.854 1.00 1.00 N +ATOM 1273 C2 U A 40 -3.973 -27.855 6.621 1.00 1.00 C +ATOM 1274 O2 U A 40 -5.058 -27.514 6.159 1.00 1.00 O +ATOM 1275 N3 U A 40 -3.122 -28.705 5.936 1.00 1.00 N +ATOM 1276 C4 U A 40 -1.885 -29.146 6.371 1.00 1.00 C +ATOM 1277 O4 U A 40 -1.209 -29.902 5.675 1.00 1.00 O +ATOM 1278 C5 U A 40 -1.500 -28.638 7.669 1.00 1.00 C +ATOM 1279 C6 U A 40 -2.317 -27.804 8.359 1.00 1.00 C +ATOM 1280 H5' U A 40 -1.992 -24.678 11.200 1.00 1.00 H +ATOM 1281 H5'' U A 40 -2.758 -25.496 12.577 1.00 1.00 H +ATOM 1282 H4' U A 40 -4.473 -24.838 11.002 1.00 1.00 H +ATOM 1283 H3' U A 40 -3.903 -27.792 11.176 1.00 1.00 H +ATOM 1284 H2' U A 40 -5.350 -28.272 9.415 1.00 1.00 H +ATOM 1285 HO2' U A 40 -7.183 -27.227 10.139 1.00 1.00 H +ATOM 1286 H1' U A 40 -5.026 -25.936 7.921 1.00 1.00 H +ATOM 1287 H3 U A 40 -3.434 -29.033 5.033 1.00 1.00 H +ATOM 1288 H5 U A 40 -0.542 -28.928 8.098 1.00 1.00 H +ATOM 1289 H6 U A 40 -2.002 -27.436 9.335 1.00 1.00 H +ATOM 1290 P C A 41 -5.719 -27.907 13.158 1.00 1.00 P +ATOM 1291 OP1 C A 41 -6.629 -27.364 14.192 1.00 1.00 O +ATOM 1292 OP2 C A 41 -4.372 -28.386 13.542 1.00 1.00 O +ATOM 1293 O5' C A 41 -6.481 -29.105 12.396 1.00 1.00 O +ATOM 1294 C5' C A 41 -7.844 -28.955 11.992 1.00 1.00 C +ATOM 1295 C4' C A 41 -8.220 -29.947 10.895 1.00 1.00 C +ATOM 1296 O4' C A 41 -7.360 -29.785 9.774 1.00 1.00 O +ATOM 1297 C3' C A 41 -8.115 -31.411 11.301 1.00 1.00 C +ATOM 1298 O3' C A 41 -9.365 -31.858 11.840 1.00 1.00 O +ATOM 1299 C2' C A 41 -7.846 -32.125 9.985 1.00 1.00 C +ATOM 1300 O2' C A 41 -9.047 -32.678 9.433 1.00 1.00 O +ATOM 1301 C1' C A 41 -7.265 -31.037 9.082 1.00 1.00 C +ATOM 1302 N1 C A 41 -5.852 -31.263 8.710 1.00 1.00 N +ATOM 1303 C2 C A 41 -5.615 -31.933 7.520 1.00 1.00 C +ATOM 1304 O2 C A 41 -6.558 -32.304 6.824 1.00 1.00 O +ATOM 1305 N3 C A 41 -4.324 -32.163 7.154 1.00 1.00 N +ATOM 1306 C4 C A 41 -3.306 -31.753 7.925 1.00 1.00 C +ATOM 1307 N4 C A 41 -2.054 -31.995 7.539 1.00 1.00 N +ATOM 1308 C5 C A 41 -3.547 -31.061 9.154 1.00 1.00 C +ATOM 1309 C6 C A 41 -4.828 -30.838 9.506 1.00 1.00 C +ATOM 1310 H5' C A 41 -7.993 -27.943 11.621 1.00 1.00 H +ATOM 1311 H5'' C A 41 -8.489 -29.116 12.855 1.00 1.00 H +ATOM 1312 H4' C A 41 -9.239 -29.744 10.573 1.00 1.00 H +ATOM 1313 H3' C A 41 -7.297 -31.566 12.005 1.00 1.00 H +ATOM 1314 H2' C A 41 -7.098 -32.904 10.139 1.00 1.00 H +ATOM 1315 HO2' C A 41 -9.592 -31.945 9.146 1.00 1.00 H +ATOM 1316 H1' C A 41 -7.868 -30.979 8.174 1.00 1.00 H +ATOM 1317 H41 C A 41 -1.878 -32.485 6.668 1.00 1.00 H +ATOM 1318 H42 C A 41 -1.280 -31.691 8.112 1.00 1.00 H +ATOM 1319 H5 C A 41 -2.721 -30.727 9.784 1.00 1.00 H +ATOM 1320 H6 C A 41 -5.048 -30.314 10.436 1.00 1.00 H +ATOM 1321 P C A 42 -9.456 -33.240 12.666 1.00 1.00 P +ATOM 1322 OP1 C A 42 -10.586 -33.134 13.617 1.00 1.00 O +ATOM 1323 OP2 C A 42 -8.102 -33.569 13.164 1.00 1.00 O +ATOM 1324 O5' C A 42 -9.853 -34.318 11.532 1.00 1.00 O +ATOM 1325 C5' C A 42 -11.147 -34.296 10.919 1.00 1.00 C +ATOM 1326 C4' C A 42 -11.210 -35.200 9.688 1.00 1.00 C +ATOM 1327 O4' C A 42 -10.215 -34.810 8.742 1.00 1.00 O +ATOM 1328 C3' C A 42 -10.973 -36.676 9.971 1.00 1.00 C +ATOM 1329 O3' C A 42 -12.217 -37.325 10.256 1.00 1.00 O +ATOM 1330 C2' C A 42 -10.406 -37.198 8.663 1.00 1.00 C +ATOM 1331 O2' C A 42 -11.440 -37.685 7.801 1.00 1.00 O +ATOM 1332 C1' C A 42 -9.714 -35.977 8.069 1.00 1.00 C +ATOM 1333 N1 C A 42 -8.251 -35.991 8.234 1.00 1.00 N +ATOM 1334 C2 C A 42 -7.507 -36.680 7.289 1.00 1.00 C +ATOM 1335 O2 C A 42 -8.073 -37.268 6.370 1.00 1.00 O +ATOM 1336 N3 C A 42 -6.151 -36.686 7.414 1.00 1.00 N +ATOM 1337 C4 C A 42 -5.551 -36.042 8.425 1.00 1.00 C +ATOM 1338 N4 C A 42 -4.221 -36.067 8.516 1.00 1.00 N +ATOM 1339 C5 C A 42 -6.315 -35.330 9.402 1.00 1.00 C +ATOM 1340 C6 C A 42 -7.656 -35.330 9.269 1.00 1.00 C +ATOM 1341 H5' C A 42 -11.382 -33.273 10.621 1.00 1.00 H +ATOM 1342 H5'' C A 42 -11.889 -34.633 11.644 1.00 1.00 H +ATOM 1343 H4' C A 42 -12.185 -35.087 9.219 1.00 1.00 H +ATOM 1344 H3' C A 42 -10.259 -36.806 10.787 1.00 1.00 H +ATOM 1345 H2' C A 42 -9.670 -37.978 8.862 1.00 1.00 H +ATOM 1346 HO2' C A 42 -12.053 -36.963 7.655 1.00 1.00 H +ATOM 1347 H1' C A 42 -9.953 -35.909 7.008 1.00 1.00 H +ATOM 1348 H41 C A 42 -3.676 -36.568 7.829 1.00 1.00 H +ATOM 1349 H42 C A 42 -3.758 -35.586 9.274 1.00 1.00 H +ATOM 1350 H5 C A 42 -5.828 -34.806 10.226 1.00 1.00 H +ATOM 1351 H6 C A 42 -8.270 -34.800 9.997 1.00 1.00 H +ATOM 1352 P U A 43 -12.245 -38.725 11.053 1.00 1.00 P +ATOM 1353 OP1 U A 43 -13.650 -39.188 11.125 1.00 1.00 O +ATOM 1354 OP2 U A 43 -11.454 -38.569 12.294 1.00 1.00 O +ATOM 1355 O5' U A 43 -11.439 -39.708 10.061 1.00 1.00 O +ATOM 1356 C5' U A 43 -11.956 -40.012 8.762 1.00 1.00 C +ATOM 1357 C4' U A 43 -11.001 -40.902 7.968 1.00 1.00 C +ATOM 1358 O4' U A 43 -9.766 -40.228 7.765 1.00 1.00 O +ATOM 1359 C3' U A 43 -10.662 -42.220 8.646 1.00 1.00 C +ATOM 1360 O3' U A 43 -11.594 -43.246 8.286 1.00 1.00 O +ATOM 1361 C2' U A 43 -9.256 -42.535 8.135 1.00 1.00 C +ATOM 1362 O2' U A 43 -9.287 -43.540 7.116 1.00 1.00 O +ATOM 1363 C1' U A 43 -8.738 -41.207 7.586 1.00 1.00 C +ATOM 1364 N1 U A 43 -7.521 -40.719 8.269 1.00 1.00 N +ATOM 1365 C2 U A 43 -6.300 -41.063 7.718 1.00 1.00 C +ATOM 1366 O2 U A 43 -6.210 -41.744 6.699 1.00 1.00 O +ATOM 1367 N3 U A 43 -5.182 -40.596 8.383 1.00 1.00 N +ATOM 1368 C4 U A 43 -5.178 -39.827 9.535 1.00 1.00 C +ATOM 1369 O4 U A 43 -4.118 -39.462 10.041 1.00 1.00 O +ATOM 1370 C5 U A 43 -6.497 -39.516 10.040 1.00 1.00 C +ATOM 1371 C6 U A 43 -7.607 -39.962 9.405 1.00 1.00 C +ATOM 1372 H5' U A 43 -12.112 -39.082 8.215 1.00 1.00 H +ATOM 1373 H5'' U A 43 -12.912 -40.524 8.870 1.00 1.00 H +ATOM 1374 H4' U A 43 -11.442 -41.110 6.995 1.00 1.00 H +ATOM 1375 H3' U A 43 -10.642 -42.083 9.730 1.00 1.00 H +ATOM 1376 HO3' U A 43 -12.458 -42.970 8.596 1.00 1.00 H +ATOM 1377 H2' U A 43 -8.623 -42.852 8.966 1.00 1.00 H +ATOM 1378 HO2' U A 43 -8.633 -44.203 7.350 1.00 1.00 H +ATOM 1379 H1' U A 43 -8.533 -41.318 6.521 1.00 1.00 H +ATOM 1380 H3 U A 43 -4.282 -40.839 7.993 1.00 1.00 H +ATOM 1381 H5 U A 43 -6.600 -38.916 10.943 1.00 1.00 H +ATOM 1382 H6 U A 43 -8.589 -39.714 9.807 1.00 1.00 H +TER 1383 U A 43 +ATOM 1384 O5' G B 44 -2.913 40.941 15.286 1.00 1.00 O +ATOM 1385 C5' G B 44 -3.590 41.960 14.547 1.00 1.00 C +ATOM 1386 C4' G B 44 -2.677 42.583 13.492 1.00 1.00 C +ATOM 1387 O4' G B 44 -1.602 43.277 14.133 1.00 1.00 O +ATOM 1388 C3' G B 44 -2.056 41.569 12.536 1.00 1.00 C +ATOM 1389 O3' G B 44 -2.804 41.534 11.316 1.00 1.00 O +ATOM 1390 C2' G B 44 -0.669 42.124 12.268 1.00 1.00 C +ATOM 1391 O2' G B 44 -0.660 42.980 11.122 1.00 1.00 O +ATOM 1392 C1' G B 44 -0.356 42.894 13.539 1.00 1.00 C +ATOM 1393 N9 G B 44 0.383 42.110 14.538 1.00 1.00 N +ATOM 1394 C8 G B 44 -0.053 41.647 15.753 1.00 1.00 C +ATOM 1395 N7 G B 44 0.848 40.981 16.419 1.00 1.00 N +ATOM 1396 C5 G B 44 1.964 41.003 15.589 1.00 1.00 C +ATOM 1397 C6 G B 44 3.254 40.436 15.782 1.00 1.00 C +ATOM 1398 O6 G B 44 3.668 39.793 16.744 1.00 1.00 O +ATOM 1399 N1 G B 44 4.088 40.689 14.702 1.00 1.00 N +ATOM 1400 C2 G B 44 3.730 41.395 13.573 1.00 1.00 C +ATOM 1401 N2 G B 44 4.674 41.532 12.640 1.00 1.00 N +ATOM 1402 N3 G B 44 2.518 41.929 13.388 1.00 1.00 N +ATOM 1403 C4 G B 44 1.689 41.693 14.434 1.00 1.00 C +ATOM 1404 H5' G B 44 -3.930 42.734 15.240 1.00 1.00 H +ATOM 1405 H5'' G B 44 -4.455 41.527 14.050 1.00 1.00 H +ATOM 1406 H4' G B 44 -3.252 43.302 12.913 1.00 1.00 H +ATOM 1407 H3' G B 44 -2.000 40.582 12.997 1.00 1.00 H +ATOM 1408 H2' G B 44 0.043 41.305 12.145 1.00 1.00 H +ATOM 1409 HO2' G B 44 0.258 43.147 10.898 1.00 1.00 H +ATOM 1410 H1' G B 44 0.217 43.786 13.289 1.00 1.00 H +ATOM 1411 H8 G B 44 -1.061 41.822 16.129 1.00 1.00 H +ATOM 1412 H1 G B 44 5.024 40.315 14.767 1.00 1.00 H +ATOM 1413 H21 G B 44 5.589 41.130 12.784 1.00 1.00 H +ATOM 1414 H22 G B 44 4.473 42.041 11.792 1.00 1.00 H +ATOM 1415 HO5' G B 44 -2.861 40.166 14.722 1.00 1.00 H +ATOM 1416 P G B 45 -2.806 40.212 10.394 1.00 1.00 P +ATOM 1417 OP1 G B 45 -3.533 40.520 9.144 1.00 1.00 O +ATOM 1418 OP2 G B 45 -3.229 39.066 11.231 1.00 1.00 O +ATOM 1419 O5' G B 45 -1.246 40.024 10.039 1.00 1.00 O +ATOM 1420 C5' G B 45 -0.551 40.987 9.239 1.00 1.00 C +ATOM 1421 C4' G B 45 0.918 40.613 9.069 1.00 1.00 C +ATOM 1422 O4' G B 45 1.577 40.608 10.333 1.00 1.00 O +ATOM 1423 C3' G B 45 1.146 39.237 8.467 1.00 1.00 C +ATOM 1424 O3' G B 45 1.194 39.344 7.038 1.00 1.00 O +ATOM 1425 C2' G B 45 2.511 38.833 9.009 1.00 1.00 C +ATOM 1426 O2' G B 45 3.551 39.134 8.072 1.00 1.00 O +ATOM 1427 C1' G B 45 2.655 39.662 10.289 1.00 1.00 C +ATOM 1428 N9 G B 45 2.611 38.865 11.526 1.00 1.00 N +ATOM 1429 C8 G B 45 1.567 38.667 12.393 1.00 1.00 C +ATOM 1430 N7 G B 45 1.865 37.915 13.417 1.00 1.00 N +ATOM 1431 C5 G B 45 3.204 37.592 13.216 1.00 1.00 C +ATOM 1432 C6 G B 45 4.079 36.795 14.006 1.00 1.00 C +ATOM 1433 O6 G B 45 3.833 36.208 15.059 1.00 1.00 O +ATOM 1434 N1 G B 45 5.347 36.722 13.447 1.00 1.00 N +ATOM 1435 C2 G B 45 5.730 37.338 12.274 1.00 1.00 C +ATOM 1436 N2 G B 45 6.994 37.152 11.896 1.00 1.00 N +ATOM 1437 N3 G B 45 4.912 38.087 11.530 1.00 1.00 N +ATOM 1438 C4 G B 45 3.669 38.168 12.060 1.00 1.00 C +ATOM 1439 H5' G B 45 -0.617 41.964 9.714 1.00 1.00 H +ATOM 1440 H5'' G B 45 -1.022 41.038 8.257 1.00 1.00 H +ATOM 1441 H4' G B 45 1.398 41.357 8.436 1.00 1.00 H +ATOM 1442 H3' G B 45 0.373 38.536 8.789 1.00 1.00 H +ATOM 1443 H2' G B 45 2.510 37.769 9.256 1.00 1.00 H +ATOM 1444 HO2' G B 45 3.232 39.842 7.511 1.00 1.00 H +ATOM 1445 H1' G B 45 3.602 40.202 10.260 1.00 1.00 H +ATOM 1446 H8 G B 45 0.576 39.094 12.239 1.00 1.00 H +ATOM 1447 H1 G B 45 6.026 36.171 13.953 1.00 1.00 H +ATOM 1448 H21 G B 45 7.609 36.588 12.457 1.00 1.00 H +ATOM 1449 H22 G B 45 7.334 37.578 11.046 1.00 1.00 H +ATOM 1450 P G B 46 0.647 38.157 6.096 1.00 1.00 P +ATOM 1451 OP1 G B 46 0.338 38.730 4.766 1.00 1.00 O +ATOM 1452 OP2 G B 46 -0.396 37.416 6.841 1.00 1.00 O +ATOM 1453 O5' G B 46 1.934 37.202 5.944 1.00 1.00 O +ATOM 1454 C5' G B 46 3.166 37.716 5.431 1.00 1.00 C +ATOM 1455 C4' G B 46 4.339 36.809 5.788 1.00 1.00 C +ATOM 1456 O4' G B 46 4.383 36.611 7.198 1.00 1.00 O +ATOM 1457 C3' G B 46 4.270 35.425 5.160 1.00 1.00 C +ATOM 1458 O3' G B 46 4.967 35.419 3.906 1.00 1.00 O +ATOM 1459 C2' G B 46 4.999 34.538 6.157 1.00 1.00 C +ATOM 1460 O2' G B 46 6.363 34.335 5.773 1.00 1.00 O +ATOM 1461 C1' G B 46 4.900 35.304 7.476 1.00 1.00 C +ATOM 1462 N9 G B 46 4.012 34.667 8.466 1.00 1.00 N +ATOM 1463 C8 G B 46 2.708 34.962 8.773 1.00 1.00 C +ATOM 1464 N7 G B 46 2.207 34.218 9.720 1.00 1.00 N +ATOM 1465 C5 G B 46 3.253 33.369 10.068 1.00 1.00 C +ATOM 1466 C6 G B 46 3.303 32.337 11.046 1.00 1.00 C +ATOM 1467 O6 G B 46 2.415 31.966 11.810 1.00 1.00 O +ATOM 1468 N1 G B 46 4.548 31.723 11.075 1.00 1.00 N +ATOM 1469 C2 G B 46 5.614 32.058 10.267 1.00 1.00 C +ATOM 1470 N2 G B 46 6.731 31.353 10.440 1.00 1.00 N +ATOM 1471 N3 G B 46 5.570 33.027 9.348 1.00 1.00 N +ATOM 1472 C4 G B 46 4.363 33.638 9.305 1.00 1.00 C +ATOM 1473 H5' G B 46 3.341 38.705 5.853 1.00 1.00 H +ATOM 1474 H5'' G B 46 3.094 37.800 4.346 1.00 1.00 H +ATOM 1475 H4' G B 46 5.265 37.291 5.479 1.00 1.00 H +ATOM 1476 H3' G B 46 3.233 35.104 5.040 1.00 1.00 H +ATOM 1477 H2' G B 46 4.479 33.585 6.250 1.00 1.00 H +ATOM 1478 HO2' G B 46 6.778 33.810 6.461 1.00 1.00 H +ATOM 1479 H1' G B 46 5.897 35.399 7.910 1.00 1.00 H +ATOM 1480 H8 G B 46 2.141 35.746 8.269 1.00 1.00 H +ATOM 1481 H1 G B 46 4.661 30.978 11.747 1.00 1.00 H +ATOM 1482 H21 G B 46 6.762 30.623 11.131 1.00 1.00 H +ATOM 1483 H22 G B 46 7.545 31.550 9.878 1.00 1.00 H +ATOM 1484 P A B 47 4.551 34.381 2.744 1.00 1.00 P +ATOM 1485 OP1 A B 47 5.027 34.923 1.451 1.00 1.00 O +ATOM 1486 OP2 A B 47 3.121 34.040 2.918 1.00 1.00 O +ATOM 1487 O5' A B 47 5.427 33.072 3.091 1.00 1.00 O +ATOM 1488 C5' A B 47 6.827 33.026 2.796 1.00 1.00 C +ATOM 1489 C4' A B 47 7.497 31.811 3.437 1.00 1.00 C +ATOM 1490 O4' A B 47 7.269 31.826 4.842 1.00 1.00 O +ATOM 1491 C3' A B 47 6.986 30.473 2.928 1.00 1.00 C +ATOM 1492 O3' A B 47 7.803 30.027 1.839 1.00 1.00 O +ATOM 1493 C2' A B 47 7.161 29.543 4.121 1.00 1.00 C +ATOM 1494 O2' A B 47 8.412 28.848 4.061 1.00 1.00 O +ATOM 1495 C1' A B 47 7.107 30.485 5.325 1.00 1.00 C +ATOM 1496 N9 A B 47 5.830 30.441 6.060 1.00 1.00 N +ATOM 1497 C8 A B 47 4.652 31.081 5.772 1.00 1.00 C +ATOM 1498 N7 A B 47 3.695 30.835 6.624 1.00 1.00 N +ATOM 1499 C5 A B 47 4.282 29.970 7.543 1.00 1.00 C +ATOM 1500 C6 A B 47 3.791 29.338 8.696 1.00 1.00 C +ATOM 1501 N6 A B 47 2.541 29.491 9.137 1.00 1.00 N +ATOM 1502 N1 A B 47 4.639 28.545 9.374 1.00 1.00 N +ATOM 1503 C2 A B 47 5.882 28.398 8.929 1.00 1.00 C +ATOM 1504 N3 A B 47 6.459 28.935 7.865 1.00 1.00 N +ATOM 1505 C4 A B 47 5.583 29.725 7.207 1.00 1.00 C +ATOM 1506 H5' A B 47 7.301 33.932 3.173 1.00 1.00 H +ATOM 1507 H5'' A B 47 6.963 32.976 1.715 1.00 1.00 H +ATOM 1508 H4' A B 47 8.570 31.867 3.263 1.00 1.00 H +ATOM 1509 H3' A B 47 5.935 30.542 2.637 1.00 1.00 H +ATOM 1510 H2' A B 47 6.328 28.836 4.166 1.00 1.00 H +ATOM 1511 HO2' A B 47 8.970 29.207 4.754 1.00 1.00 H +ATOM 1512 H1' A B 47 7.921 30.244 6.008 1.00 1.00 H +ATOM 1513 H8 A B 47 4.525 31.735 4.908 1.00 1.00 H +ATOM 1514 H61 A B 47 2.238 29.013 9.973 1.00 1.00 H +ATOM 1515 H62 A B 47 1.898 30.085 8.633 1.00 1.00 H +ATOM 1516 H2 A B 47 6.517 27.741 9.525 1.00 1.00 H +ATOM 1517 P U B 48 7.167 29.169 0.633 1.00 1.00 P +ATOM 1518 OP1 U B 48 8.263 28.762 -0.272 1.00 1.00 O +ATOM 1519 OP2 U B 48 6.006 29.914 0.098 1.00 1.00 O +ATOM 1520 O5' U B 48 6.618 27.855 1.384 1.00 1.00 O +ATOM 1521 C5' U B 48 7.510 26.801 1.758 1.00 1.00 C +ATOM 1522 C4' U B 48 6.858 25.844 2.751 1.00 1.00 C +ATOM 1523 O4' U B 48 6.322 26.582 3.841 1.00 1.00 O +ATOM 1524 C3' U B 48 5.712 25.029 2.175 1.00 1.00 C +ATOM 1525 O3' U B 48 6.214 23.777 1.697 1.00 1.00 O +ATOM 1526 C2' U B 48 4.798 24.791 3.374 1.00 1.00 C +ATOM 1527 O2' U B 48 5.033 23.505 3.956 1.00 1.00 O +ATOM 1528 C1' U B 48 5.159 25.917 4.349 1.00 1.00 C +ATOM 1529 N1 U B 48 4.100 26.938 4.509 1.00 1.00 N +ATOM 1530 C2 U B 48 3.263 26.829 5.601 1.00 1.00 C +ATOM 1531 O2 U B 48 3.376 25.923 6.423 1.00 1.00 O +ATOM 1532 N3 U B 48 2.288 27.803 5.719 1.00 1.00 N +ATOM 1533 C4 U B 48 2.079 28.859 4.849 1.00 1.00 C +ATOM 1534 O4 U B 48 1.177 29.670 5.053 1.00 1.00 O +ATOM 1535 C5 U B 48 3.000 28.895 3.735 1.00 1.00 C +ATOM 1536 C6 U B 48 3.965 27.952 3.599 1.00 1.00 C +ATOM 1537 H5' U B 48 8.401 27.233 2.213 1.00 1.00 H +ATOM 1538 H5'' U B 48 7.801 26.246 0.865 1.00 1.00 H +ATOM 1539 H4' U B 48 7.616 25.165 3.136 1.00 1.00 H +ATOM 1540 H3' U B 48 5.194 25.581 1.388 1.00 1.00 H +ATOM 1541 H2' U B 48 3.754 24.889 3.066 1.00 1.00 H +ATOM 1542 HO2' U B 48 4.850 22.848 3.278 1.00 1.00 H +ATOM 1543 H1' U B 48 5.394 25.484 5.321 1.00 1.00 H +ATOM 1544 H3 U B 48 1.668 27.735 6.514 1.00 1.00 H +ATOM 1545 H5 U B 48 2.918 29.691 2.995 1.00 1.00 H +ATOM 1546 H6 U B 48 4.645 28.002 2.750 1.00 1.00 H +ATOM 1547 P A B 49 5.812 23.229 0.236 1.00 1.00 P +ATOM 1548 OP1 A B 49 6.455 24.096 -0.778 1.00 1.00 O +ATOM 1549 OP2 A B 49 4.349 23.016 0.207 1.00 1.00 O +ATOM 1550 O5' A B 49 6.533 21.789 0.199 1.00 1.00 O +ATOM 1551 C5' A B 49 7.825 21.615 0.787 1.00 1.00 C +ATOM 1552 C4' A B 49 7.743 20.837 2.102 1.00 1.00 C +ATOM 1553 O4' A B 49 6.509 21.153 2.756 1.00 1.00 O +ATOM 1554 C3' A B 49 7.812 19.316 1.944 1.00 1.00 C +ATOM 1555 O3' A B 49 8.793 18.786 2.847 1.00 1.00 O +ATOM 1556 C2' A B 49 6.429 18.815 2.343 1.00 1.00 C +ATOM 1557 O2' A B 49 6.513 17.603 3.100 1.00 1.00 O +ATOM 1558 C1' A B 49 5.866 19.950 3.180 1.00 1.00 C +ATOM 1559 N9 A B 49 4.408 20.144 3.035 1.00 1.00 N +ATOM 1560 C8 A B 49 3.700 20.464 1.906 1.00 1.00 C +ATOM 1561 N7 A B 49 2.416 20.581 2.103 1.00 1.00 N +ATOM 1562 C5 A B 49 2.264 20.317 3.461 1.00 1.00 C +ATOM 1563 C6 A B 49 1.139 20.282 4.302 1.00 1.00 C +ATOM 1564 N6 A B 49 -0.101 20.524 3.875 1.00 1.00 N +ATOM 1565 N1 A B 49 1.347 19.986 5.596 1.00 1.00 N +ATOM 1566 C2 A B 49 2.583 19.746 6.017 1.00 1.00 C +ATOM 1567 N3 A B 49 3.714 19.750 5.329 1.00 1.00 N +ATOM 1568 C4 A B 49 3.473 20.050 4.035 1.00 1.00 C +ATOM 1569 H5' A B 49 8.260 22.595 0.981 1.00 1.00 H +ATOM 1570 H5'' A B 49 8.466 21.078 0.087 1.00 1.00 H +ATOM 1571 H4' A B 49 8.560 21.157 2.745 1.00 1.00 H +ATOM 1572 H3' A B 49 8.038 19.038 0.914 1.00 1.00 H +ATOM 1573 H2' A B 49 5.814 18.671 1.451 1.00 1.00 H +ATOM 1574 HO2' A B 49 7.439 17.455 3.301 1.00 1.00 H +ATOM 1575 H1' A B 49 6.100 19.771 4.224 1.00 1.00 H +ATOM 1576 H8 A B 49 4.167 20.608 0.930 1.00 1.00 H +ATOM 1577 H61 A B 49 -0.872 20.484 4.521 1.00 1.00 H +ATOM 1578 H62 A B 49 -0.264 20.746 2.905 1.00 1.00 H +ATOM 1579 H2 A B 49 2.679 19.512 7.076 1.00 1.00 H +ATOM 1580 P U B 50 8.744 19.099 4.432 1.00 1.00 P +ATOM 1581 OP1 U B 50 8.009 20.365 4.650 1.00 1.00 O +ATOM 1582 OP2 U B 50 10.112 18.940 4.972 1.00 1.00 O +ATOM 1583 O5' U B 50 7.840 17.896 5.001 1.00 1.00 O +ATOM 1584 C5' U B 50 8.362 17.000 5.986 1.00 1.00 C +ATOM 1585 C4' U B 50 7.599 17.113 7.303 1.00 1.00 C +ATOM 1586 O4' U B 50 7.710 18.437 7.811 1.00 1.00 O +ATOM 1587 C3' U B 50 6.112 16.814 7.176 1.00 1.00 C +ATOM 1588 O3' U B 50 5.870 15.451 7.533 1.00 1.00 O +ATOM 1589 C2' U B 50 5.447 17.732 8.197 1.00 1.00 C +ATOM 1590 O2' U B 50 5.036 16.999 9.358 1.00 1.00 O +ATOM 1591 C1' U B 50 6.531 18.760 8.554 1.00 1.00 C +ATOM 1592 N1 U B 50 6.184 20.167 8.229 1.00 1.00 N +ATOM 1593 C2 U B 50 6.486 21.136 9.167 1.00 1.00 C +ATOM 1594 O2 U B 50 7.006 20.860 10.247 1.00 1.00 O +ATOM 1595 N3 U B 50 6.168 22.436 8.822 1.00 1.00 N +ATOM 1596 C4 U B 50 5.582 22.846 7.637 1.00 1.00 C +ATOM 1597 O4 U B 50 5.344 24.035 7.434 1.00 1.00 O +ATOM 1598 C5 U B 50 5.300 21.768 6.716 1.00 1.00 C +ATOM 1599 C6 U B 50 5.603 20.486 7.032 1.00 1.00 C +ATOM 1600 H5' U B 50 9.410 17.235 6.162 1.00 1.00 H +ATOM 1601 H5'' U B 50 8.283 15.978 5.614 1.00 1.00 H +ATOM 1602 H4' U B 50 8.038 16.427 8.025 1.00 1.00 H +ATOM 1603 H3' U B 50 5.756 17.029 6.169 1.00 1.00 H +ATOM 1604 H2' U B 50 4.587 18.232 7.738 1.00 1.00 H +ATOM 1605 HO2' U B 50 4.302 17.475 9.751 1.00 1.00 H +ATOM 1606 H1' U B 50 6.751 18.677 9.621 1.00 1.00 H +ATOM 1607 H3 U B 50 6.384 23.155 9.498 1.00 1.00 H +ATOM 1608 H5 U B 50 4.837 21.990 5.754 1.00 1.00 H +ATOM 1609 H6 U B 50 5.378 19.692 6.319 1.00 1.00 H +ATOM 1610 P G B 51 4.608 14.662 6.922 1.00 1.00 P +ATOM 1611 OP1 G B 51 4.617 13.282 7.459 1.00 1.00 O +ATOM 1612 OP2 G B 51 4.593 14.883 5.458 1.00 1.00 O +ATOM 1613 O5' G B 51 3.355 15.444 7.562 1.00 1.00 O +ATOM 1614 C5' G B 51 2.744 16.537 6.866 1.00 1.00 C +ATOM 1615 C4' G B 51 1.522 16.086 6.067 1.00 1.00 C +ATOM 1616 O4' G B 51 1.183 17.090 5.110 1.00 1.00 O +ATOM 1617 C3' G B 51 1.729 14.786 5.303 1.00 1.00 C +ATOM 1618 O3' G B 51 1.180 13.695 6.047 1.00 1.00 O +ATOM 1619 C2' G B 51 0.937 14.970 4.021 1.00 1.00 C +ATOM 1620 O2' G B 51 -0.360 14.374 4.118 1.00 1.00 O +ATOM 1621 C1' G B 51 0.844 16.481 3.856 1.00 1.00 C +ATOM 1622 N9 G B 51 1.765 17.013 2.839 1.00 1.00 N +ATOM 1623 C8 G B 51 3.091 17.336 2.974 1.00 1.00 C +ATOM 1624 N7 G B 51 3.641 17.783 1.881 1.00 1.00 N +ATOM 1625 C5 G B 51 2.606 17.756 0.951 1.00 1.00 C +ATOM 1626 C6 G B 51 2.607 18.129 -0.422 1.00 1.00 C +ATOM 1627 O6 G B 51 3.539 18.565 -1.094 1.00 1.00 O +ATOM 1628 N1 G B 51 1.357 17.947 -0.999 1.00 1.00 N +ATOM 1629 C2 G B 51 0.245 17.466 -0.343 1.00 1.00 C +ATOM 1630 N2 G B 51 -0.867 17.361 -1.068 1.00 1.00 N +ATOM 1631 N3 G B 51 0.242 17.114 0.947 1.00 1.00 N +ATOM 1632 C4 G B 51 1.454 17.285 1.528 1.00 1.00 C +ATOM 1633 H5' G B 51 3.472 16.976 6.184 1.00 1.00 H +ATOM 1634 H5'' G B 51 2.437 17.292 7.589 1.00 1.00 H +ATOM 1635 H4' G B 51 0.682 15.964 6.750 1.00 1.00 H +ATOM 1636 H3' G B 51 2.783 14.625 5.083 1.00 1.00 H +ATOM 1637 H2' G B 51 1.495 14.548 3.184 1.00 1.00 H +ATOM 1638 HO2' G B 51 -0.480 13.823 3.340 1.00 1.00 H +ATOM 1639 H1' G B 51 -0.176 16.752 3.589 1.00 1.00 H +ATOM 1640 H8 G B 51 3.636 17.231 3.914 1.00 1.00 H +ATOM 1641 H1 G B 51 1.280 18.192 -1.976 1.00 1.00 H +ATOM 1642 H21 G B 51 -0.859 17.627 -2.040 1.00 1.00 H +ATOM 1643 H22 G B 51 -1.714 17.017 -0.650 1.00 1.00 H +ATOM 1644 P G B 52 1.393 12.181 5.545 1.00 1.00 P +ATOM 1645 OP1 G B 52 0.666 11.281 6.467 1.00 1.00 O +ATOM 1646 OP2 G B 52 2.837 11.976 5.297 1.00 1.00 O +ATOM 1647 O5' G B 52 0.632 12.172 4.128 1.00 1.00 O +ATOM 1648 C5' G B 52 1.255 11.598 2.975 1.00 1.00 C +ATOM 1649 C4' G B 52 0.261 11.423 1.831 1.00 1.00 C +ATOM 1650 O4' G B 52 -0.103 12.703 1.310 1.00 1.00 O +ATOM 1651 C3' G B 52 0.800 10.603 0.667 1.00 1.00 C +ATOM 1652 O3' G B 52 0.414 9.234 0.824 1.00 1.00 O +ATOM 1653 C2' G B 52 0.103 11.202 -0.544 1.00 1.00 C +ATOM 1654 O2' G B 52 -1.114 10.507 -0.840 1.00 1.00 O +ATOM 1655 C1' G B 52 -0.168 12.642 -0.121 1.00 1.00 C +ATOM 1656 N9 G B 52 0.807 13.612 -0.654 1.00 1.00 N +ATOM 1657 C8 G B 52 1.867 14.204 -0.015 1.00 1.00 C +ATOM 1658 N7 G B 52 2.550 15.019 -0.770 1.00 1.00 N +ATOM 1659 C5 G B 52 1.898 14.965 -1.998 1.00 1.00 C +ATOM 1660 C6 G B 52 2.186 15.643 -3.215 1.00 1.00 C +ATOM 1661 O6 G B 52 3.092 16.440 -3.448 1.00 1.00 O +ATOM 1662 N1 G B 52 1.282 15.305 -4.213 1.00 1.00 N +ATOM 1663 C2 G B 52 0.230 14.426 -4.063 1.00 1.00 C +ATOM 1664 N2 G B 52 -0.533 14.230 -5.138 1.00 1.00 N +ATOM 1665 N3 G B 52 -0.043 13.788 -2.921 1.00 1.00 N +ATOM 1666 C4 G B 52 0.829 14.105 -1.936 1.00 1.00 C +ATOM 1667 H5' G B 52 1.668 10.625 3.240 1.00 1.00 H +ATOM 1668 H5'' G B 52 2.063 12.251 2.647 1.00 1.00 H +ATOM 1669 H4' G B 52 -0.635 10.940 2.215 1.00 1.00 H +ATOM 1670 H3' G B 52 1.883 10.707 0.584 1.00 1.00 H +ATOM 1671 H2' G B 52 0.774 11.190 -1.404 1.00 1.00 H +ATOM 1672 HO2' G B 52 -1.249 9.860 -0.145 1.00 1.00 H +ATOM 1673 H1' G B 52 -1.167 12.929 -0.447 1.00 1.00 H +ATOM 1674 H8 G B 52 2.114 14.013 1.029 1.00 1.00 H +ATOM 1675 H1 G B 52 1.423 15.749 -5.109 1.00 1.00 H +ATOM 1676 H21 G B 52 -0.324 14.713 -6.001 1.00 1.00 H +ATOM 1677 H22 G B 52 -1.319 13.597 -5.091 1.00 1.00 H +ATOM 1678 P A B 53 1.485 8.048 0.615 1.00 1.00 P +ATOM 1679 OP1 A B 53 0.938 6.817 1.228 1.00 1.00 O +ATOM 1680 OP2 A B 53 2.815 8.550 1.029 1.00 1.00 O +ATOM 1681 O5' A B 53 1.496 7.851 -0.984 1.00 1.00 O +ATOM 1682 C5' A B 53 0.343 7.345 -1.660 1.00 1.00 C +ATOM 1683 C4' A B 53 0.422 7.585 -3.165 1.00 1.00 C +ATOM 1684 O4' A B 53 0.465 8.981 -3.435 1.00 1.00 O +ATOM 1685 C3' A B 53 1.648 6.987 -3.836 1.00 1.00 C +ATOM 1686 O3' A B 53 1.369 5.644 -4.253 1.00 1.00 O +ATOM 1687 C2' A B 53 1.854 7.878 -5.050 1.00 1.00 C +ATOM 1688 O2' A B 53 1.249 7.315 -6.220 1.00 1.00 O +ATOM 1689 C1' A B 53 1.183 9.195 -4.657 1.00 1.00 C +ATOM 1690 N9 A B 53 2.129 10.306 -4.442 1.00 1.00 N +ATOM 1691 C8 A B 53 2.824 10.647 -3.310 1.00 1.00 C +ATOM 1692 N7 A B 53 3.591 11.691 -3.457 1.00 1.00 N +ATOM 1693 C5 A B 53 3.391 12.068 -4.782 1.00 1.00 C +ATOM 1694 C6 A B 53 3.919 13.110 -5.564 1.00 1.00 C +ATOM 1695 N6 A B 53 4.795 14.001 -5.098 1.00 1.00 N +ATOM 1696 N1 A B 53 3.506 13.193 -6.840 1.00 1.00 N +ATOM 1697 C2 A B 53 2.633 12.303 -7.298 1.00 1.00 C +ATOM 1698 N3 A B 53 2.068 11.286 -6.666 1.00 1.00 N +ATOM 1699 C4 A B 53 2.502 11.229 -5.389 1.00 1.00 C +ATOM 1700 H5' A B 53 -0.545 7.842 -1.268 1.00 1.00 H +ATOM 1701 H5'' A B 53 0.262 6.274 -1.473 1.00 1.00 H +ATOM 1702 H4' A B 53 -0.469 7.175 -3.633 1.00 1.00 H +ATOM 1703 H3' A B 53 2.515 7.026 -3.172 1.00 1.00 H +ATOM 1704 H2' A B 53 2.920 8.044 -5.210 1.00 1.00 H +ATOM 1705 HO2' A B 53 1.901 6.739 -6.629 1.00 1.00 H +ATOM 1706 H1' A B 53 0.478 9.480 -5.437 1.00 1.00 H +ATOM 1707 H8 A B 53 2.743 10.096 -2.373 1.00 1.00 H +ATOM 1708 H61 A B 53 5.143 14.730 -5.703 1.00 1.00 H +ATOM 1709 H62 A B 53 5.111 13.946 -4.140 1.00 1.00 H +ATOM 1710 H2 A B 53 2.342 12.428 -8.340 1.00 1.00 H +ATOM 1711 P A B 54 2.569 4.615 -4.574 1.00 1.00 P +ATOM 1712 OP1 A B 54 2.058 3.238 -4.392 1.00 1.00 O +ATOM 1713 OP2 A B 54 3.771 5.060 -3.832 1.00 1.00 O +ATOM 1714 O5' A B 54 2.831 4.850 -6.149 1.00 1.00 O +ATOM 1715 C5' A B 54 1.873 4.414 -7.118 1.00 1.00 C +ATOM 1716 C4' A B 54 2.156 4.998 -8.502 1.00 1.00 C +ATOM 1717 O4' A B 54 2.252 6.423 -8.409 1.00 1.00 O +ATOM 1718 C3' A B 54 3.451 4.508 -9.145 1.00 1.00 C +ATOM 1719 O3' A B 54 3.179 3.379 -9.988 1.00 1.00 O +ATOM 1720 C2' A B 54 3.877 5.696 -9.991 1.00 1.00 C +ATOM 1721 O2' A B 54 3.276 5.659 -11.290 1.00 1.00 O +ATOM 1722 C1' A B 54 3.376 6.877 -9.177 1.00 1.00 C +ATOM 1723 N9 A B 54 4.375 7.405 -8.238 1.00 1.00 N +ATOM 1724 C8 A B 54 4.573 7.090 -6.918 1.00 1.00 C +ATOM 1725 N7 A B 54 5.562 7.735 -6.364 1.00 1.00 N +ATOM 1726 C5 A B 54 6.055 8.533 -7.392 1.00 1.00 C +ATOM 1727 C6 A B 54 7.110 9.458 -7.452 1.00 1.00 C +ATOM 1728 N6 A B 54 7.895 9.738 -6.410 1.00 1.00 N +ATOM 1729 N1 A B 54 7.325 10.075 -8.626 1.00 1.00 N +ATOM 1730 C2 A B 54 6.542 9.786 -9.660 1.00 1.00 C +ATOM 1731 N3 A B 54 5.526 8.941 -9.730 1.00 1.00 N +ATOM 1732 C4 A B 54 5.337 8.340 -8.536 1.00 1.00 C +ATOM 1733 H5' A B 54 0.878 4.726 -6.798 1.00 1.00 H +ATOM 1734 H5'' A B 54 1.900 3.326 -7.181 1.00 1.00 H +ATOM 1735 H4' A B 54 1.326 4.754 -9.161 1.00 1.00 H +ATOM 1736 H3' A B 54 4.202 4.274 -8.387 1.00 1.00 H +ATOM 1737 H2' A B 54 4.962 5.736 -10.069 1.00 1.00 H +ATOM 1738 HO2' A B 54 3.947 5.929 -11.921 1.00 1.00 H +ATOM 1739 H1' A B 54 3.062 7.676 -9.849 1.00 1.00 H +ATOM 1740 H8 A B 54 3.961 6.367 -6.380 1.00 1.00 H +ATOM 1741 H61 A B 54 8.640 10.411 -6.507 1.00 1.00 H +ATOM 1742 H62 A B 54 7.742 9.280 -5.523 1.00 1.00 H +ATOM 1743 H2 A B 54 6.772 10.321 -10.583 1.00 1.00 H +ATOM 1744 P G B 55 4.015 2.008 -9.829 1.00 1.00 P +ATOM 1745 OP1 G B 55 3.319 0.954 -10.599 1.00 1.00 O +ATOM 1746 OP2 G B 55 4.297 1.803 -8.390 1.00 1.00 O +ATOM 1747 O5' G B 55 5.407 2.333 -10.572 1.00 1.00 O +ATOM 1748 C5' G B 55 5.516 2.221 -11.995 1.00 1.00 C +ATOM 1749 C4' G B 55 6.867 2.723 -12.500 1.00 1.00 C +ATOM 1750 O4' G B 55 6.993 4.118 -12.242 1.00 1.00 O +ATOM 1751 C3' G B 55 8.075 2.056 -11.858 1.00 1.00 C +ATOM 1752 O3' G B 55 8.436 0.885 -12.604 1.00 1.00 O +ATOM 1753 C2' G B 55 9.155 3.117 -11.982 1.00 1.00 C +ATOM 1754 O2' G B 55 9.897 2.967 -13.197 1.00 1.00 O +ATOM 1755 C1' G B 55 8.367 4.423 -11.968 1.00 1.00 C +ATOM 1756 N9 G B 55 8.420 5.129 -10.674 1.00 1.00 N +ATOM 1757 C8 G B 55 7.550 5.062 -9.617 1.00 1.00 C +ATOM 1758 N7 G B 55 7.869 5.838 -8.619 1.00 1.00 N +ATOM 1759 C5 G B 55 9.037 6.466 -9.044 1.00 1.00 C +ATOM 1760 C6 G B 55 9.850 7.424 -8.379 1.00 1.00 C +ATOM 1761 O6 G B 55 9.693 7.918 -7.264 1.00 1.00 O +ATOM 1762 N1 G B 55 10.936 7.798 -9.158 1.00 1.00 N +ATOM 1763 C2 G B 55 11.209 7.315 -10.419 1.00 1.00 C +ATOM 1764 N2 G B 55 12.305 7.791 -11.008 1.00 1.00 N +ATOM 1765 N3 G B 55 10.446 6.414 -11.048 1.00 1.00 N +ATOM 1766 C4 G B 55 9.381 6.037 -10.302 1.00 1.00 C +ATOM 1767 H5' G B 55 4.723 2.809 -12.458 1.00 1.00 H +ATOM 1768 H5'' G B 55 5.395 1.176 -12.281 1.00 1.00 H +ATOM 1769 H4' G B 55 6.915 2.571 -13.576 1.00 1.00 H +ATOM 1770 H3' G B 55 7.879 1.819 -10.810 1.00 1.00 H +ATOM 1771 H2' G B 55 9.818 3.085 -11.116 1.00 1.00 H +ATOM 1772 HO2' G B 55 10.755 3.376 -13.060 1.00 1.00 H +ATOM 1773 H1' G B 55 8.750 5.081 -12.746 1.00 1.00 H +ATOM 1774 H8 G B 55 6.672 4.415 -9.608 1.00 1.00 H +ATOM 1775 H1 G B 55 11.560 8.480 -8.751 1.00 1.00 H +ATOM 1776 H21 G B 55 12.878 8.468 -10.533 1.00 1.00 H +ATOM 1777 H22 G B 55 12.558 7.474 -11.932 1.00 1.00 H +ATOM 1778 P A B 56 9.233 -0.334 -11.908 1.00 1.00 P +ATOM 1779 OP1 A B 56 9.253 -1.471 -12.854 1.00 1.00 O +ATOM 1780 OP2 A B 56 8.691 -0.521 -10.543 1.00 1.00 O +ATOM 1781 O5' A B 56 10.737 0.235 -11.778 1.00 1.00 O +ATOM 1782 C5' A B 56 11.547 0.421 -12.944 1.00 1.00 C +ATOM 1783 C4' A B 56 12.843 1.161 -12.619 1.00 1.00 C +ATOM 1784 O4' A B 56 12.544 2.473 -12.147 1.00 1.00 O +ATOM 1785 C3' A B 56 13.696 0.502 -11.545 1.00 1.00 C +ATOM 1786 O3' A B 56 14.629 -0.412 -12.139 1.00 1.00 O +ATOM 1787 C2' A B 56 14.444 1.671 -10.929 1.00 1.00 C +ATOM 1788 O2' A B 56 15.726 1.854 -11.541 1.00 1.00 O +ATOM 1789 C1' A B 56 13.528 2.861 -11.178 1.00 1.00 C +ATOM 1790 N9 A B 56 12.824 3.310 -9.967 1.00 1.00 N +ATOM 1791 C8 A B 56 11.704 2.791 -9.372 1.00 1.00 C +ATOM 1792 N7 A B 56 11.331 3.433 -8.299 1.00 1.00 N +ATOM 1793 C5 A B 56 12.272 4.451 -8.177 1.00 1.00 C +ATOM 1794 C6 A B 56 12.437 5.482 -7.237 1.00 1.00 C +ATOM 1795 N6 A B 56 11.620 5.661 -6.199 1.00 1.00 N +ATOM 1796 N1 A B 56 13.476 6.316 -7.413 1.00 1.00 N +ATOM 1797 C2 A B 56 14.288 6.130 -8.448 1.00 1.00 C +ATOM 1798 N3 A B 56 14.238 5.202 -9.393 1.00 1.00 N +ATOM 1799 C4 A B 56 13.185 4.383 -9.189 1.00 1.00 C +ATOM 1800 H5' A B 56 10.984 0.998 -13.676 1.00 1.00 H +ATOM 1801 H5'' A B 56 11.789 -0.553 -13.370 1.00 1.00 H +ATOM 1802 H4' A B 56 13.433 1.251 -13.529 1.00 1.00 H +ATOM 1803 H3' A B 56 13.070 0.006 -10.800 1.00 1.00 H +ATOM 1804 H2' A B 56 14.545 1.518 -9.860 1.00 1.00 H +ATOM 1805 HO2' A B 56 16.011 0.998 -11.868 1.00 1.00 H +ATOM 1806 H1' A B 56 14.114 3.692 -11.573 1.00 1.00 H +ATOM 1807 H8 A B 56 11.173 1.920 -9.759 1.00 1.00 H +ATOM 1808 H61 A B 56 11.783 6.417 -5.556 1.00 1.00 H +ATOM 1809 H62 A B 56 10.835 5.040 -6.060 1.00 1.00 H +ATOM 1810 H2 A B 56 15.110 6.840 -8.531 1.00 1.00 H +ATOM 1811 P A B 57 15.315 -1.578 -11.256 1.00 1.00 P +ATOM 1812 OP1 A B 57 15.738 -2.660 -12.173 1.00 1.00 O +ATOM 1813 OP2 A B 57 14.418 -1.884 -10.119 1.00 1.00 O +ATOM 1814 O5' A B 57 16.645 -0.872 -10.670 1.00 1.00 O +ATOM 1815 C5' A B 57 17.820 -0.726 -11.483 1.00 1.00 C +ATOM 1816 C4' A B 57 18.959 -0.045 -10.719 1.00 1.00 C +ATOM 1817 O4' A B 57 18.555 1.271 -10.336 1.00 1.00 O +ATOM 1818 C3' A B 57 19.390 -0.765 -9.445 1.00 1.00 C +ATOM 1819 O3' A B 57 20.519 -1.603 -9.720 1.00 1.00 O +ATOM 1820 C2' A B 57 19.799 0.374 -8.526 1.00 1.00 C +ATOM 1821 O2' A B 57 21.169 0.745 -8.724 1.00 1.00 O +ATOM 1822 C1' A B 57 18.852 1.484 -8.948 1.00 1.00 C +ATOM 1823 N9 A B 57 17.574 1.476 -8.219 1.00 1.00 N +ATOM 1824 C8 A B 57 16.448 0.735 -8.471 1.00 1.00 C +ATOM 1825 N7 A B 57 15.458 0.988 -7.661 1.00 1.00 N +ATOM 1826 C5 A B 57 15.964 1.968 -6.811 1.00 1.00 C +ATOM 1827 C6 A B 57 15.407 2.663 -5.726 1.00 1.00 C +ATOM 1828 N6 A B 57 14.159 2.466 -5.295 1.00 1.00 N +ATOM 1829 N1 A B 57 16.186 3.564 -5.105 1.00 1.00 N +ATOM 1830 C2 A B 57 17.426 3.757 -5.539 1.00 1.00 C +ATOM 1831 N3 A B 57 18.061 3.170 -6.543 1.00 1.00 N +ATOM 1832 C4 A B 57 17.254 2.270 -7.145 1.00 1.00 C +ATOM 1833 H5' A B 57 17.572 -0.128 -12.361 1.00 1.00 H +ATOM 1834 H5'' A B 57 18.152 -1.711 -11.806 1.00 1.00 H +ATOM 1835 H4' A B 57 19.819 0.042 -11.378 1.00 1.00 H +ATOM 1836 H3' A B 57 18.562 -1.336 -9.018 1.00 1.00 H +ATOM 1837 H2' A B 57 19.617 0.104 -7.487 1.00 1.00 H +ATOM 1838 HO2' A B 57 21.498 1.076 -7.885 1.00 1.00 H +ATOM 1839 H1' A B 57 19.336 2.452 -8.819 1.00 1.00 H +ATOM 1840 H8 A B 57 16.387 0.000 -9.275 1.00 1.00 H +ATOM 1841 H61 A B 57 13.807 2.996 -4.504 1.00 1.00 H +ATOM 1842 H62 A B 57 13.566 1.788 -5.755 1.00 1.00 H +ATOM 1843 H2 A B 57 18.003 4.501 -4.991 1.00 1.00 H +ATOM 1844 P C B 58 20.752 -2.968 -8.893 1.00 1.00 P +ATOM 1845 OP1 C B 58 22.068 -3.522 -9.280 1.00 1.00 O +ATOM 1846 OP2 C B 58 19.535 -3.798 -9.024 1.00 1.00 O +ATOM 1847 O5' C B 58 20.851 -2.457 -7.368 1.00 1.00 O +ATOM 1848 C5' C B 58 22.077 -1.935 -6.851 1.00 1.00 C +ATOM 1849 C4' C B 58 21.923 -1.477 -5.402 1.00 1.00 C +ATOM 1850 O4' C B 58 21.015 -0.384 -5.328 1.00 1.00 O +ATOM 1851 C3' C B 58 21.375 -2.533 -4.463 1.00 1.00 C +ATOM 1852 O3' C B 58 22.443 -3.332 -3.946 1.00 1.00 O +ATOM 1853 C2' C B 58 20.749 -1.706 -3.348 1.00 1.00 C +ATOM 1854 O2' C B 58 21.682 -1.463 -2.290 1.00 1.00 O +ATOM 1855 C1' C B 58 20.353 -0.405 -4.052 1.00 1.00 C +ATOM 1856 N1 C B 58 18.900 -0.284 -4.308 1.00 1.00 N +ATOM 1857 C2 C B 58 18.144 0.463 -3.418 1.00 1.00 C +ATOM 1858 O2 C B 58 18.684 1.005 -2.456 1.00 1.00 O +ATOM 1859 N3 C B 58 16.806 0.575 -3.644 1.00 1.00 N +ATOM 1860 C4 C B 58 16.234 -0.020 -4.700 1.00 1.00 C +ATOM 1861 N4 C B 58 14.921 0.107 -4.892 1.00 1.00 N +ATOM 1862 C5 C B 58 17.012 -0.790 -5.621 1.00 1.00 C +ATOM 1863 C6 C B 58 18.334 -0.895 -5.389 1.00 1.00 C +ATOM 1864 H5' C B 58 22.388 -1.086 -7.460 1.00 1.00 H +ATOM 1865 H5'' C B 58 22.844 -2.708 -6.901 1.00 1.00 H +ATOM 1866 H4' C B 58 22.891 -1.144 -5.032 1.00 1.00 H +ATOM 1867 H3' C B 58 20.623 -3.146 -4.963 1.00 1.00 H +ATOM 1868 H2' C B 58 19.857 -2.207 -2.969 1.00 1.00 H +ATOM 1869 HO2' C B 58 22.314 -0.818 -2.611 1.00 1.00 H +ATOM 1870 H1' C B 58 20.689 0.443 -3.457 1.00 1.00 H +ATOM 1871 H41 C B 58 14.366 0.650 -4.241 1.00 1.00 H +ATOM 1872 H42 C B 58 14.480 -0.338 -5.684 1.00 1.00 H +ATOM 1873 H5 C B 58 16.550 -1.272 -6.484 1.00 1.00 H +ATOM 1874 H6 C B 58 18.958 -1.471 -6.072 1.00 1.00 H +ATOM 1875 P C B 59 22.165 -4.839 -3.450 1.00 1.00 P +ATOM 1876 OP1 C B 59 23.405 -5.360 -2.834 1.00 1.00 O +ATOM 1877 OP2 C B 59 21.523 -5.581 -4.560 1.00 1.00 O +ATOM 1878 O5' C B 59 21.073 -4.626 -2.286 1.00 1.00 O +ATOM 1879 C5' C B 59 21.435 -3.962 -1.073 1.00 1.00 C +ATOM 1880 C4' C B 59 20.214 -3.414 -0.339 1.00 1.00 C +ATOM 1881 O4' C B 59 19.444 -2.601 -1.216 1.00 1.00 O +ATOM 1882 C3' C B 59 19.261 -4.471 0.198 1.00 1.00 C +ATOM 1883 O3' C B 59 19.639 -4.818 1.537 1.00 1.00 O +ATOM 1884 C2' C B 59 17.918 -3.757 0.226 1.00 1.00 C +ATOM 1885 O2' C B 59 17.605 -3.277 1.536 1.00 1.00 O +ATOM 1886 C1' C B 59 18.082 -2.608 -0.769 1.00 1.00 C +ATOM 1887 N1 C B 59 17.188 -2.695 -1.945 1.00 1.00 N +ATOM 1888 C2 C B 59 15.997 -1.990 -1.876 1.00 1.00 C +ATOM 1889 O2 C B 59 15.722 -1.341 -0.869 1.00 1.00 O +ATOM 1890 N3 C B 59 15.152 -2.043 -2.943 1.00 1.00 N +ATOM 1891 C4 C B 59 15.463 -2.759 -4.031 1.00 1.00 C +ATOM 1892 N4 C B 59 14.613 -2.789 -5.057 1.00 1.00 N +ATOM 1893 C5 C B 59 16.691 -3.489 -4.107 1.00 1.00 C +ATOM 1894 C6 C B 59 17.520 -3.430 -3.046 1.00 1.00 C +ATOM 1895 H5' C B 59 22.108 -3.139 -1.307 1.00 1.00 H +ATOM 1896 H5'' C B 59 21.952 -4.669 -0.423 1.00 1.00 H +ATOM 1897 H4' C B 59 20.552 -2.794 0.488 1.00 1.00 H +ATOM 1898 H3' C B 59 19.232 -5.346 -0.452 1.00 1.00 H +ATOM 1899 H2' C B 59 17.142 -4.435 -0.133 1.00 1.00 H +ATOM 1900 HO2' C B 59 16.920 -2.611 1.441 1.00 1.00 H +ATOM 1901 H1' C B 59 17.890 -1.670 -0.244 1.00 1.00 H +ATOM 1902 H41 C B 59 13.746 -2.275 -5.009 1.00 1.00 H +ATOM 1903 H42 C B 59 14.835 -3.325 -5.883 1.00 1.00 H +ATOM 1904 H5 C B 59 16.948 -4.071 -4.993 1.00 1.00 H +ATOM 1905 H6 C B 59 18.465 -3.975 -3.069 1.00 1.00 H +ATOM 1906 P G B 60 18.925 -6.044 2.302 1.00 1.00 P +ATOM 1907 OP1 G B 60 19.857 -6.545 3.336 1.00 1.00 O +ATOM 1908 OP2 G B 60 18.385 -6.972 1.284 1.00 1.00 O +ATOM 1909 O5' G B 60 17.680 -5.332 3.047 1.00 1.00 O +ATOM 1910 C5' G B 60 17.901 -4.400 4.113 1.00 1.00 C +ATOM 1911 C4' G B 60 16.584 -3.914 4.727 1.00 1.00 C +ATOM 1912 O4' G B 60 15.878 -3.095 3.795 1.00 1.00 O +ATOM 1913 C3' G B 60 15.634 -5.030 5.130 1.00 1.00 C +ATOM 1914 O3' G B 60 15.852 -5.393 6.496 1.00 1.00 O +ATOM 1915 C2' G B 60 14.259 -4.404 4.984 1.00 1.00 C +ATOM 1916 O2' G B 60 13.815 -3.824 6.215 1.00 1.00 O +ATOM 1917 C1' G B 60 14.467 -3.340 3.912 1.00 1.00 C +ATOM 1918 N9 G B 60 13.981 -3.741 2.585 1.00 1.00 N +ATOM 1919 C8 G B 60 14.692 -4.275 1.543 1.00 1.00 C +ATOM 1920 N7 G B 60 13.973 -4.526 0.484 1.00 1.00 N +ATOM 1921 C5 G B 60 12.690 -4.130 0.850 1.00 1.00 C +ATOM 1922 C6 G B 60 11.479 -4.166 0.104 1.00 1.00 C +ATOM 1923 O6 G B 60 11.302 -4.562 -1.046 1.00 1.00 O +ATOM 1924 N1 G B 60 10.412 -3.675 0.843 1.00 1.00 N +ATOM 1925 C2 G B 60 10.494 -3.207 2.138 1.00 1.00 C +ATOM 1926 N2 G B 60 9.357 -2.776 2.681 1.00 1.00 N +ATOM 1927 N3 G B 60 11.631 -3.171 2.840 1.00 1.00 N +ATOM 1928 C4 G B 60 12.685 -3.647 2.135 1.00 1.00 C +ATOM 1929 H5' G B 60 18.448 -3.541 3.725 1.00 1.00 H +ATOM 1930 H5'' G B 60 18.497 -4.880 4.889 1.00 1.00 H +ATOM 1931 H4' G B 60 16.810 -3.314 5.605 1.00 1.00 H +ATOM 1932 H3' G B 60 15.742 -5.892 4.469 1.00 1.00 H +ATOM 1933 H2' G B 60 13.546 -5.152 4.630 1.00 1.00 H +ATOM 1934 HO2' G B 60 13.799 -2.871 6.093 1.00 1.00 H +ATOM 1935 H1' G B 60 13.964 -2.422 4.213 1.00 1.00 H +ATOM 1936 H8 G B 60 15.763 -4.473 1.593 1.00 1.00 H +ATOM 1937 H1 G B 60 9.515 -3.669 0.379 1.00 1.00 H +ATOM 1938 H21 G B 60 8.500 -2.804 2.148 1.00 1.00 H +ATOM 1939 H22 G B 60 9.352 -2.421 3.627 1.00 1.00 H +ATOM 1940 P G B 61 15.393 -6.841 7.031 1.00 1.00 P +ATOM 1941 OP1 G B 61 15.654 -6.900 8.486 1.00 1.00 O +ATOM 1942 OP2 G B 61 15.969 -7.869 6.135 1.00 1.00 O +ATOM 1943 O5' G B 61 13.796 -6.813 6.805 1.00 1.00 O +ATOM 1944 C5' G B 61 12.964 -5.939 7.577 1.00 1.00 C +ATOM 1945 C4' G B 61 11.484 -6.124 7.244 1.00 1.00 C +ATOM 1946 O4' G B 61 11.194 -5.619 5.947 1.00 1.00 O +ATOM 1947 C3' G B 61 11.013 -7.566 7.245 1.00 1.00 C +ATOM 1948 O3' G B 61 10.605 -7.944 8.565 1.00 1.00 O +ATOM 1949 C2' G B 61 9.813 -7.544 6.311 1.00 1.00 C +ATOM 1950 O2' G B 61 8.586 -7.412 7.035 1.00 1.00 O +ATOM 1951 C1' G B 61 10.068 -6.334 5.413 1.00 1.00 C +ATOM 1952 N9 G B 61 10.384 -6.682 4.016 1.00 1.00 N +ATOM 1953 C8 G B 61 11.593 -7.033 3.473 1.00 1.00 C +ATOM 1954 N7 G B 61 11.549 -7.273 2.192 1.00 1.00 N +ATOM 1955 C5 G B 61 10.213 -7.067 1.858 1.00 1.00 C +ATOM 1956 C6 G B 61 9.562 -7.181 0.598 1.00 1.00 C +ATOM 1957 O6 G B 61 10.048 -7.493 -0.488 1.00 1.00 O +ATOM 1958 N1 G B 61 8.209 -6.888 0.696 1.00 1.00 N +ATOM 1959 C2 G B 61 7.559 -6.529 1.857 1.00 1.00 C +ATOM 1960 N2 G B 61 6.253 -6.286 1.751 1.00 1.00 N +ATOM 1961 N3 G B 61 8.169 -6.422 3.043 1.00 1.00 N +ATOM 1962 C4 G B 61 9.492 -6.705 2.968 1.00 1.00 C +ATOM 1963 H5' G B 61 13.247 -4.907 7.367 1.00 1.00 H +ATOM 1964 H5'' G B 61 13.120 -6.141 8.636 1.00 1.00 H +ATOM 1965 H4' G B 61 10.893 -5.564 7.966 1.00 1.00 H +ATOM 1966 H3' G B 61 11.792 -8.229 6.864 1.00 1.00 H +ATOM 1967 H2' G B 61 9.805 -8.447 5.704 1.00 1.00 H +ATOM 1968 HO2' G B 61 7.975 -8.065 6.682 1.00 1.00 H +ATOM 1969 H1' G B 61 9.192 -5.686 5.428 1.00 1.00 H +ATOM 1970 H8 G B 61 12.509 -7.102 4.059 1.00 1.00 H +ATOM 1971 H1 G B 61 7.678 -6.948 -0.161 1.00 1.00 H +ATOM 1972 H21 G B 61 5.797 -6.368 0.854 1.00 1.00 H +ATOM 1973 H22 G B 61 5.722 -6.019 2.567 1.00 1.00 H +ATOM 1974 P G B 62 10.494 -9.498 8.976 1.00 1.00 P +ATOM 1975 OP1 G B 62 10.254 -9.576 10.433 1.00 1.00 O +ATOM 1976 OP2 G B 62 11.640 -10.219 8.376 1.00 1.00 O +ATOM 1977 O5' G B 62 9.151 -9.967 8.218 1.00 1.00 O +ATOM 1978 C5' G B 62 7.890 -9.382 8.554 1.00 1.00 C +ATOM 1979 C4' G B 62 6.788 -9.823 7.595 1.00 1.00 C +ATOM 1980 O4' G B 62 7.066 -9.361 6.283 1.00 1.00 O +ATOM 1981 C3' G B 62 6.614 -11.325 7.483 1.00 1.00 C +ATOM 1982 O3' G B 62 5.707 -11.771 8.499 1.00 1.00 O +ATOM 1983 C2' G B 62 5.996 -11.499 6.098 1.00 1.00 C +ATOM 1984 O2' G B 62 4.567 -11.577 6.173 1.00 1.00 O +ATOM 1985 C1' G B 62 6.452 -10.247 5.335 1.00 1.00 C +ATOM 1986 N9 G B 62 7.444 -10.508 4.277 1.00 1.00 N +ATOM 1987 C8 G B 62 8.802 -10.645 4.386 1.00 1.00 C +ATOM 1988 N7 G B 62 9.407 -10.856 3.250 1.00 1.00 N +ATOM 1989 C5 G B 62 8.374 -10.859 2.318 1.00 1.00 C +ATOM 1990 C6 G B 62 8.421 -11.042 0.908 1.00 1.00 C +ATOM 1991 O6 G B 62 9.403 -11.240 0.196 1.00 1.00 O +ATOM 1992 N1 G B 62 7.154 -10.971 0.343 1.00 1.00 N +ATOM 1993 C2 G B 62 5.987 -10.754 1.044 1.00 1.00 C +ATOM 1994 N2 G B 62 4.865 -10.719 0.326 1.00 1.00 N +ATOM 1995 N3 G B 62 5.941 -10.582 2.368 1.00 1.00 N +ATOM 1996 C4 G B 62 7.168 -10.646 2.937 1.00 1.00 C +ATOM 1997 H5' G B 62 7.980 -8.296 8.516 1.00 1.00 H +ATOM 1998 H5'' G B 62 7.618 -9.680 9.568 1.00 1.00 H +ATOM 1999 H4' G B 62 5.845 -9.384 7.919 1.00 1.00 H +ATOM 2000 H3' G B 62 7.577 -11.837 7.550 1.00 1.00 H +ATOM 2001 H2' G B 62 6.407 -12.394 5.620 1.00 1.00 H +ATOM 2002 HO2' G B 62 4.352 -12.183 6.886 1.00 1.00 H +ATOM 2003 H1' G B 62 5.585 -9.754 4.893 1.00 1.00 H +ATOM 2004 H8 G B 62 9.331 -10.583 5.338 1.00 1.00 H +ATOM 2005 H1 G B 62 7.108 -11.092 -0.659 1.00 1.00 H +ATOM 2006 H21 G B 62 4.903 -10.849 -0.675 1.00 1.00 H +ATOM 2007 H22 G B 62 3.978 -10.562 0.781 1.00 1.00 H +ATOM 2008 P G B 63 5.883 -13.216 9.188 1.00 1.00 P +ATOM 2009 OP1 G B 63 4.998 -13.272 10.374 1.00 1.00 O +ATOM 2010 OP2 G B 63 7.329 -13.489 9.335 1.00 1.00 O +ATOM 2011 O5' G B 63 5.289 -14.212 8.073 1.00 1.00 O +ATOM 2012 C5' G B 63 5.913 -15.471 7.822 1.00 1.00 C +ATOM 2013 C4' G B 63 5.512 -16.026 6.461 1.00 1.00 C +ATOM 2014 O4' G B 63 5.652 -15.009 5.474 1.00 1.00 O +ATOM 2015 C3' G B 63 6.347 -17.213 6.009 1.00 1.00 C +ATOM 2016 O3' G B 63 5.666 -18.427 6.338 1.00 1.00 O +ATOM 2017 C2' G B 63 6.414 -17.051 4.497 1.00 1.00 C +ATOM 2018 O2' G B 63 5.359 -17.771 3.853 1.00 1.00 O +ATOM 2019 C1' G B 63 6.264 -15.546 4.295 1.00 1.00 C +ATOM 2020 N9 G B 63 7.541 -14.838 4.109 1.00 1.00 N +ATOM 2021 C8 G B 63 8.443 -14.429 5.057 1.00 1.00 C +ATOM 2022 N7 G B 63 9.488 -13.823 4.568 1.00 1.00 N +ATOM 2023 C5 G B 63 9.266 -13.829 3.195 1.00 1.00 C +ATOM 2024 C6 G B 63 10.068 -13.308 2.142 1.00 1.00 C +ATOM 2025 O6 G B 63 11.150 -12.732 2.220 1.00 1.00 O +ATOM 2026 N1 G B 63 9.482 -13.522 0.902 1.00 1.00 N +ATOM 2027 C2 G B 63 8.276 -14.156 0.696 1.00 1.00 C +ATOM 2028 N2 G B 63 7.878 -14.265 -0.571 1.00 1.00 N +ATOM 2029 N3 G B 63 7.519 -14.648 1.684 1.00 1.00 N +ATOM 2030 C4 G B 63 8.076 -14.448 2.903 1.00 1.00 C +ATOM 2031 H5' G B 63 5.616 -16.178 8.597 1.00 1.00 H +ATOM 2032 H5'' G B 63 6.995 -15.343 7.850 1.00 1.00 H +ATOM 2033 H4' G B 63 4.466 -16.325 6.499 1.00 1.00 H +ATOM 2034 H3' G B 63 7.345 -17.181 6.450 1.00 1.00 H +ATOM 2035 H2' G B 63 7.388 -17.381 4.130 1.00 1.00 H +ATOM 2036 HO2' G B 63 5.087 -17.256 3.090 1.00 1.00 H +ATOM 2037 H1' G B 63 5.622 -15.355 3.434 1.00 1.00 H +ATOM 2038 H8 G B 63 8.299 -14.593 6.125 1.00 1.00 H +ATOM 2039 H1 G B 63 9.995 -13.179 0.104 1.00 1.00 H +ATOM 2040 H21 G B 63 8.452 -13.892 -1.314 1.00 1.00 H +ATOM 2041 H22 G B 63 7.004 -14.718 -0.787 1.00 1.00 H +ATOM 2042 P A B 64 6.426 -19.599 7.136 1.00 1.00 P +ATOM 2043 OP1 A B 64 5.417 -20.383 7.884 1.00 1.00 O +ATOM 2044 OP2 A B 64 7.576 -19.002 7.851 1.00 1.00 O +ATOM 2045 O5' A B 64 6.994 -20.518 5.943 1.00 1.00 O +ATOM 2046 C5' A B 64 8.026 -21.475 6.189 1.00 1.00 C +ATOM 2047 C4' A B 64 8.425 -22.200 4.908 1.00 1.00 C +ATOM 2048 O4' A B 64 7.347 -23.046 4.489 1.00 1.00 O +ATOM 2049 C3' A B 64 8.756 -21.256 3.752 1.00 1.00 C +ATOM 2050 O3' A B 64 10.169 -21.254 3.525 1.00 1.00 O +ATOM 2051 C2' A B 64 8.054 -21.858 2.545 1.00 1.00 C +ATOM 2052 O2' A B 64 8.952 -22.654 1.764 1.00 1.00 O +ATOM 2053 C1' A B 64 6.952 -22.709 3.155 1.00 1.00 C +ATOM 2054 N9 A B 64 5.645 -22.029 3.234 1.00 1.00 N +ATOM 2055 C8 A B 64 5.091 -21.352 4.289 1.00 1.00 C +ATOM 2056 N7 A B 64 3.904 -20.871 4.045 1.00 1.00 N +ATOM 2057 C5 A B 64 3.652 -21.256 2.733 1.00 1.00 C +ATOM 2058 C6 A B 64 2.555 -21.053 1.879 1.00 1.00 C +ATOM 2059 N6 A B 64 1.464 -20.380 2.242 1.00 1.00 N +ATOM 2060 N1 A B 64 2.633 -21.572 0.643 1.00 1.00 N +ATOM 2061 C2 A B 64 3.724 -22.240 0.287 1.00 1.00 C +ATOM 2062 N3 A B 64 4.815 -22.495 0.993 1.00 1.00 N +ATOM 2063 C4 A B 64 4.707 -21.963 2.230 1.00 1.00 C +ATOM 2064 H5' A B 64 7.669 -22.205 6.916 1.00 1.00 H +ATOM 2065 H5'' A B 64 8.898 -20.962 6.596 1.00 1.00 H +ATOM 2066 H4' A B 64 9.293 -22.824 5.112 1.00 1.00 H +ATOM 2067 H3' A B 64 8.388 -20.248 3.953 1.00 1.00 H +ATOM 2068 H2' A B 64 7.615 -21.065 1.936 1.00 1.00 H +ATOM 2069 HO2' A B 64 8.643 -23.561 1.810 1.00 1.00 H +ATOM 2070 H1' A B 64 6.841 -23.624 2.573 1.00 1.00 H +ATOM 2071 H8 A B 64 5.596 -21.229 5.247 1.00 1.00 H +ATOM 2072 H61 A B 64 0.702 -20.263 1.590 1.00 1.00 H +ATOM 2073 H62 A B 64 1.397 -19.987 3.171 1.00 1.00 H +ATOM 2074 H2 A B 64 3.720 -22.632 -0.730 1.00 1.00 H +ATOM 2075 P A B 65 10.812 -20.255 2.439 1.00 1.00 P +ATOM 2076 OP1 A B 65 11.604 -21.057 1.480 1.00 1.00 O +ATOM 2077 OP2 A B 65 11.447 -19.130 3.163 1.00 1.00 O +ATOM 2078 O5' A B 65 9.510 -19.696 1.679 1.00 1.00 O +ATOM 2079 C5' A B 65 9.595 -19.225 0.332 1.00 1.00 C +ATOM 2080 C4' A B 65 8.836 -20.143 -0.627 1.00 1.00 C +ATOM 2081 O4' A B 65 7.699 -20.694 0.048 1.00 1.00 O +ATOM 2082 C3' A B 65 8.336 -19.455 -1.898 1.00 1.00 C +ATOM 2083 O3' A B 65 9.185 -19.805 -2.998 1.00 1.00 O +ATOM 2084 C2' A B 65 6.950 -20.043 -2.116 1.00 1.00 C +ATOM 2085 O2' A B 65 7.001 -21.176 -2.992 1.00 1.00 O +ATOM 2086 C1' A B 65 6.515 -20.445 -0.714 1.00 1.00 C +ATOM 2087 N9 A B 65 5.741 -19.410 -0.002 1.00 1.00 N +ATOM 2088 C8 A B 65 6.084 -18.702 1.123 1.00 1.00 C +ATOM 2089 N7 A B 65 5.171 -17.851 1.506 1.00 1.00 N +ATOM 2090 C5 A B 65 4.155 -18.007 0.567 1.00 1.00 C +ATOM 2091 C6 A B 65 2.903 -17.390 0.408 1.00 1.00 C +ATOM 2092 N6 A B 65 2.444 -16.447 1.232 1.00 1.00 N +ATOM 2093 N1 A B 65 2.148 -17.786 -0.631 1.00 1.00 N +ATOM 2094 C2 A B 65 2.610 -18.724 -1.448 1.00 1.00 C +ATOM 2095 N3 A B 65 3.762 -19.374 -1.404 1.00 1.00 N +ATOM 2096 C4 A B 65 4.496 -18.956 -0.352 1.00 1.00 C +ATOM 2097 H5' A B 65 10.642 -19.183 0.033 1.00 1.00 H +ATOM 2098 H5'' A B 65 9.171 -18.222 0.283 1.00 1.00 H +ATOM 2099 H4' A B 65 9.491 -20.964 -0.912 1.00 1.00 H +ATOM 2100 H3' A B 65 8.282 -18.374 -1.766 1.00 1.00 H +ATOM 2101 H2' A B 65 6.278 -19.278 -2.512 1.00 1.00 H +ATOM 2102 HO2' A B 65 7.927 -21.365 -3.160 1.00 1.00 H +ATOM 2103 H1' A B 65 5.923 -21.358 -0.768 1.00 1.00 H +ATOM 2104 H8 A B 65 7.031 -18.838 1.647 1.00 1.00 H +ATOM 2105 H61 A B 65 1.536 -16.036 1.074 1.00 1.00 H +ATOM 2106 H62 A B 65 3.005 -16.145 2.016 1.00 1.00 H +ATOM 2107 H2 A B 65 1.948 -18.999 -2.269 1.00 1.00 H +ATOM 2108 P A B 66 9.670 -18.684 -4.050 1.00 1.00 P +ATOM 2109 OP1 A B 66 10.450 -19.354 -5.115 1.00 1.00 O +ATOM 2110 OP2 A B 66 10.272 -17.566 -3.290 1.00 1.00 O +ATOM 2111 O5' A B 66 8.285 -18.167 -4.690 1.00 1.00 O +ATOM 2112 C5' A B 66 7.663 -18.883 -5.761 1.00 1.00 C +ATOM 2113 C4' A B 66 6.333 -18.248 -6.157 1.00 1.00 C +ATOM 2114 O4' A B 66 5.399 -18.391 -5.086 1.00 1.00 O +ATOM 2115 C3' A B 66 6.426 -16.762 -6.477 1.00 1.00 C +ATOM 2116 O3' A B 66 6.562 -16.582 -7.891 1.00 1.00 O +ATOM 2117 C2' A B 66 5.087 -16.211 -6.014 1.00 1.00 C +ATOM 2118 O2' A B 66 4.123 -16.222 -7.072 1.00 1.00 O +ATOM 2119 C1' A B 66 4.690 -17.160 -4.890 1.00 1.00 C +ATOM 2120 N9 A B 66 5.033 -16.664 -3.546 1.00 1.00 N +ATOM 2121 C8 A B 66 6.237 -16.721 -2.892 1.00 1.00 C +ATOM 2122 N7 A B 66 6.222 -16.170 -1.710 1.00 1.00 N +ATOM 2123 C5 A B 66 4.915 -15.715 -1.572 1.00 1.00 C +ATOM 2124 C6 A B 66 4.251 -15.037 -0.537 1.00 1.00 C +ATOM 2125 N6 A B 66 4.844 -14.679 0.602 1.00 1.00 N +ATOM 2126 N1 A B 66 2.954 -14.741 -0.727 1.00 1.00 N +ATOM 2127 C2 A B 66 2.370 -15.094 -1.865 1.00 1.00 C +ATOM 2128 N3 A B 66 2.884 -15.729 -2.908 1.00 1.00 N +ATOM 2129 C4 A B 66 4.184 -16.013 -2.686 1.00 1.00 C +ATOM 2130 H5' A B 66 7.486 -19.911 -5.447 1.00 1.00 H +ATOM 2131 H5'' A B 66 8.329 -18.883 -6.625 1.00 1.00 H +ATOM 2132 H4' A B 66 5.941 -18.771 -7.027 1.00 1.00 H +ATOM 2133 H3' A B 66 7.250 -16.296 -5.935 1.00 1.00 H +ATOM 2134 H2' A B 66 5.217 -15.201 -5.618 1.00 1.00 H +ATOM 2135 HO2' A B 66 4.349 -16.948 -7.656 1.00 1.00 H +ATOM 2136 H1' A B 66 3.618 -17.348 -4.938 1.00 1.00 H +ATOM 2137 H8 A B 66 7.125 -17.187 -3.321 1.00 1.00 H +ATOM 2138 H61 A B 66 4.318 -14.192 1.313 1.00 1.00 H +ATOM 2139 H62 A B 66 5.821 -14.895 0.756 1.00 1.00 H +ATOM 2140 H2 A B 66 1.319 -14.823 -1.954 1.00 1.00 H +ATOM 2141 P C B 67 7.276 -15.267 -8.489 1.00 1.00 P +ATOM 2142 OP1 C B 67 7.115 -15.282 -9.961 1.00 1.00 O +ATOM 2143 OP2 C B 67 8.629 -15.165 -7.895 1.00 1.00 O +ATOM 2144 O5' C B 67 6.373 -14.072 -7.896 1.00 1.00 O +ATOM 2145 C5' C B 67 4.980 -13.991 -8.208 1.00 1.00 C +ATOM 2146 C4' C B 67 4.221 -13.165 -7.173 1.00 1.00 C +ATOM 2147 O4' C B 67 4.517 -13.649 -5.863 1.00 1.00 O +ATOM 2148 C3' C B 67 4.563 -11.683 -7.174 1.00 1.00 C +ATOM 2149 O3' C B 67 3.659 -10.977 -8.030 1.00 1.00 O +ATOM 2150 C2' C B 67 4.333 -11.266 -5.733 1.00 1.00 C +ATOM 2151 O2' C B 67 2.996 -10.796 -5.534 1.00 1.00 O +ATOM 2152 C1' C B 67 4.594 -12.547 -4.949 1.00 1.00 C +ATOM 2153 N1 C B 67 5.923 -12.584 -4.307 1.00 1.00 N +ATOM 2154 C2 C B 67 6.025 -12.066 -3.026 1.00 1.00 C +ATOM 2155 O2 C B 67 5.032 -11.602 -2.468 1.00 1.00 O +ATOM 2156 N3 C B 67 7.243 -12.086 -2.416 1.00 1.00 N +ATOM 2157 C4 C B 67 8.315 -12.594 -3.038 1.00 1.00 C +ATOM 2158 N4 C B 67 9.493 -12.599 -2.413 1.00 1.00 N +ATOM 2159 C5 C B 67 8.214 -13.129 -4.361 1.00 1.00 C +ATOM 2160 C6 C B 67 7.005 -13.105 -4.955 1.00 1.00 C +ATOM 2161 H5' C B 67 4.562 -14.998 -8.237 1.00 1.00 H +ATOM 2162 H5'' C B 67 4.861 -13.529 -9.188 1.00 1.00 H +ATOM 2163 H4' C B 67 3.153 -13.279 -7.345 1.00 1.00 H +ATOM 2164 H3' C B 67 5.603 -11.521 -7.468 1.00 1.00 H +ATOM 2165 H2' C B 67 5.057 -10.504 -5.446 1.00 1.00 H +ATOM 2166 HO2' C B 67 2.641 -11.257 -4.771 1.00 1.00 H +ATOM 2167 H1' C B 67 3.826 -12.661 -4.186 1.00 1.00 H +ATOM 2168 H41 C B 67 9.570 -12.223 -1.480 1.00 1.00 H +ATOM 2169 H42 C B 67 10.308 -12.980 -2.873 1.00 1.00 H +ATOM 2170 H5 C B 67 9.085 -13.542 -4.871 1.00 1.00 H +ATOM 2171 H6 C B 67 6.890 -13.506 -5.962 1.00 1.00 H +ATOM 2172 P U B 68 4.033 -9.520 -8.606 1.00 1.00 P +ATOM 2173 OP1 U B 68 2.954 -9.095 -9.525 1.00 1.00 O +ATOM 2174 OP2 U B 68 5.434 -9.556 -9.082 1.00 1.00 O +ATOM 2175 O5' U B 68 3.970 -8.590 -7.289 1.00 1.00 O +ATOM 2176 C5' U B 68 2.752 -8.458 -6.550 1.00 1.00 C +ATOM 2177 C4' U B 68 2.968 -7.725 -5.225 1.00 1.00 C +ATOM 2178 O4' U B 68 3.904 -8.439 -4.422 1.00 1.00 O +ATOM 2179 C3' U B 68 3.518 -6.314 -5.364 1.00 1.00 C +ATOM 2180 O3' U B 68 2.441 -5.374 -5.461 1.00 1.00 O +ATOM 2181 C2' U B 68 4.275 -6.097 -4.066 1.00 1.00 C +ATOM 2182 O2' U B 68 3.468 -5.416 -3.099 1.00 1.00 O +ATOM 2183 C1' U B 68 4.628 -7.508 -3.600 1.00 1.00 C +ATOM 2184 N1 U B 68 6.067 -7.831 -3.716 1.00 1.00 N +ATOM 2185 C2 U B 68 6.865 -7.635 -2.604 1.00 1.00 C +ATOM 2186 O2 U B 68 6.415 -7.203 -1.545 1.00 1.00 O +ATOM 2187 N3 U B 68 8.203 -7.951 -2.753 1.00 1.00 N +ATOM 2188 C4 U B 68 8.804 -8.441 -3.900 1.00 1.00 C +ATOM 2189 O4 U B 68 10.009 -8.689 -3.920 1.00 1.00 O +ATOM 2190 C5 U B 68 7.897 -8.616 -5.012 1.00 1.00 C +ATOM 2191 C6 U B 68 6.581 -8.313 -4.890 1.00 1.00 C +ATOM 2192 H5' U B 68 2.352 -9.452 -6.346 1.00 1.00 H +ATOM 2193 H5'' U B 68 2.031 -7.903 -7.151 1.00 1.00 H +ATOM 2194 H4' U B 68 2.022 -7.683 -4.690 1.00 1.00 H +ATOM 2195 H3' U B 68 4.187 -6.241 -6.223 1.00 1.00 H +ATOM 2196 H2' U B 68 5.186 -5.540 -4.266 1.00 1.00 H +ATOM 2197 HO2' U B 68 2.872 -6.063 -2.720 1.00 1.00 H +ATOM 2198 H1' U B 68 4.314 -7.630 -2.563 1.00 1.00 H +ATOM 2199 H3 U B 68 8.798 -7.812 -1.949 1.00 1.00 H +ATOM 2200 H5 U B 68 8.275 -8.996 -5.960 1.00 1.00 H +ATOM 2201 H6 U B 68 5.920 -8.452 -5.744 1.00 1.00 H +ATOM 2202 P U B 69 2.706 -3.873 -5.990 1.00 1.00 P +ATOM 2203 OP1 U B 69 1.403 -3.279 -6.360 1.00 1.00 O +ATOM 2204 OP2 U B 69 3.803 -3.922 -6.984 1.00 1.00 O +ATOM 2205 O5' U B 69 3.252 -3.114 -4.673 1.00 1.00 O +ATOM 2206 C5' U B 69 2.401 -2.916 -3.538 1.00 1.00 C +ATOM 2207 C4' U B 69 3.188 -2.479 -2.299 1.00 1.00 C +ATOM 2208 O4' U B 69 4.119 -3.493 -1.933 1.00 1.00 O +ATOM 2209 C3' U B 69 4.002 -1.210 -2.472 1.00 1.00 C +ATOM 2210 O3' U B 69 3.204 -0.065 -2.145 1.00 1.00 O +ATOM 2211 C2' U B 69 5.121 -1.380 -1.455 1.00 1.00 C +ATOM 2212 O2' U B 69 4.766 -0.841 -0.178 1.00 1.00 O +ATOM 2213 C1' U B 69 5.305 -2.890 -1.380 1.00 1.00 C +ATOM 2214 N1 U B 69 6.454 -3.368 -2.174 1.00 1.00 N +ATOM 2215 C2 U B 69 7.632 -3.667 -1.515 1.00 1.00 C +ATOM 2216 O2 U B 69 7.755 -3.534 -0.299 1.00 1.00 O +ATOM 2217 N3 U B 69 8.670 -4.127 -2.308 1.00 1.00 N +ATOM 2218 C4 U B 69 8.630 -4.310 -3.679 1.00 1.00 C +ATOM 2219 O4 U B 69 9.615 -4.726 -4.285 1.00 1.00 O +ATOM 2220 C5 U B 69 7.360 -3.971 -4.282 1.00 1.00 C +ATOM 2221 C6 U B 69 6.329 -3.520 -3.527 1.00 1.00 C +ATOM 2222 H5' U B 69 1.883 -3.850 -3.318 1.00 1.00 H +ATOM 2223 H5'' U B 69 1.663 -2.151 -3.777 1.00 1.00 H +ATOM 2224 H4' U B 69 2.494 -2.341 -1.475 1.00 1.00 H +ATOM 2225 H3' U B 69 4.404 -1.139 -3.485 1.00 1.00 H +ATOM 2226 H2' U B 69 6.035 -0.925 -1.833 1.00 1.00 H +ATOM 2227 HO2' U B 69 5.360 -1.226 0.469 1.00 1.00 H +ATOM 2228 H1' U B 69 5.422 -3.196 -0.341 1.00 1.00 H +ATOM 2229 H3 U B 69 9.537 -4.350 -1.841 1.00 1.00 H +ATOM 2230 H5 U B 69 7.230 -4.078 -5.359 1.00 1.00 H +ATOM 2231 H6 U B 69 5.382 -3.274 -4.006 1.00 1.00 H +ATOM 2232 P G B 70 3.627 1.407 -2.655 1.00 1.00 P +ATOM 2233 OP1 G B 70 2.581 2.363 -2.228 1.00 1.00 O +ATOM 2234 OP2 G B 70 4.007 1.315 -4.083 1.00 1.00 O +ATOM 2235 O5' G B 70 4.957 1.695 -1.796 1.00 1.00 O +ATOM 2236 C5' G B 70 4.901 1.676 -0.368 1.00 1.00 C +ATOM 2237 C4' G B 70 6.274 1.430 0.247 1.00 1.00 C +ATOM 2238 O4' G B 70 6.876 0.291 -0.360 1.00 1.00 O +ATOM 2239 C3' G B 70 7.272 2.565 0.075 1.00 1.00 C +ATOM 2240 O3' G B 70 7.162 3.472 1.181 1.00 1.00 O +ATOM 2241 C2' G B 70 8.614 1.856 0.141 1.00 1.00 C +ATOM 2242 O2' G B 70 9.177 1.929 1.456 1.00 1.00 O +ATOM 2243 C1' G B 70 8.296 0.413 -0.244 1.00 1.00 C +ATOM 2244 N9 G B 70 8.929 -0.032 -1.498 1.00 1.00 N +ATOM 2245 C8 G B 70 8.440 -0.039 -2.780 1.00 1.00 C +ATOM 2246 N7 G B 70 9.256 -0.560 -3.654 1.00 1.00 N +ATOM 2247 C5 G B 70 10.368 -0.922 -2.899 1.00 1.00 C +ATOM 2248 C6 G B 70 11.585 -1.536 -3.304 1.00 1.00 C +ATOM 2249 O6 G B 70 11.921 -1.895 -4.430 1.00 1.00 O +ATOM 2250 N1 G B 70 12.444 -1.723 -2.228 1.00 1.00 N +ATOM 2251 C2 G B 70 12.168 -1.364 -0.925 1.00 1.00 C +ATOM 2252 N2 G B 70 13.118 -1.617 -0.028 1.00 1.00 N +ATOM 2253 N3 G B 70 11.025 -0.789 -0.543 1.00 1.00 N +ATOM 2254 C4 G B 70 10.177 -0.598 -1.579 1.00 1.00 C +ATOM 2255 H5' G B 70 4.224 0.884 -0.050 1.00 1.00 H +ATOM 2256 H5'' G B 70 4.519 2.633 -0.015 1.00 1.00 H +ATOM 2257 H4' G B 70 6.152 1.224 1.307 1.00 1.00 H +ATOM 2258 H3' G B 70 7.137 3.073 -0.881 1.00 1.00 H +ATOM 2259 H2' G B 70 9.299 2.287 -0.592 1.00 1.00 H +ATOM 2260 HO2' G B 70 9.155 1.044 1.823 1.00 1.00 H +ATOM 2261 H1' G B 70 8.629 -0.244 0.558 1.00 1.00 H +ATOM 2262 H8 G B 70 7.460 0.359 -3.045 1.00 1.00 H +ATOM 2263 H1 G B 70 13.330 -2.158 -2.438 1.00 1.00 H +ATOM 2264 H21 G B 70 13.990 -2.053 -0.318 1.00 1.00 H +ATOM 2265 H22 G B 70 12.973 -1.376 0.942 1.00 1.00 H +ATOM 2266 P G B 71 7.922 4.894 1.163 1.00 1.00 P +ATOM 2267 OP1 G B 71 7.250 5.784 2.135 1.00 1.00 O +ATOM 2268 OP2 G B 71 8.070 5.319 -0.246 1.00 1.00 O +ATOM 2269 O5' G B 71 9.388 4.536 1.740 1.00 1.00 O +ATOM 2270 C5' G B 71 9.619 4.436 3.152 1.00 1.00 C +ATOM 2271 C4' G B 71 11.101 4.606 3.496 1.00 1.00 C +ATOM 2272 O4' G B 71 11.771 3.343 3.459 1.00 1.00 O +ATOM 2273 C3' G B 71 11.844 5.540 2.551 1.00 1.00 C +ATOM 2274 O3' G B 71 11.877 6.859 3.106 1.00 1.00 O +ATOM 2275 C2' G B 71 13.246 4.957 2.499 1.00 1.00 C +ATOM 2276 O2' G B 71 14.088 5.523 3.507 1.00 1.00 O +ATOM 2277 C1' G B 71 13.007 3.472 2.739 1.00 1.00 C +ATOM 2278 N9 G B 71 12.868 2.689 1.504 1.00 1.00 N +ATOM 2279 C8 G B 71 11.721 2.167 0.963 1.00 1.00 C +ATOM 2280 N7 G B 71 11.906 1.525 -0.154 1.00 1.00 N +ATOM 2281 C5 G B 71 13.276 1.624 -0.374 1.00 1.00 C +ATOM 2282 C6 G B 71 14.064 1.113 -1.442 1.00 1.00 C +ATOM 2283 O6 G B 71 13.695 0.464 -2.420 1.00 1.00 O +ATOM 2284 N1 G B 71 15.404 1.436 -1.285 1.00 1.00 N +ATOM 2285 C2 G B 71 15.926 2.157 -0.233 1.00 1.00 C +ATOM 2286 N2 G B 71 17.242 2.364 -0.260 1.00 1.00 N +ATOM 2287 N3 G B 71 15.188 2.640 0.773 1.00 1.00 N +ATOM 2288 C4 G B 71 13.875 2.336 0.636 1.00 1.00 C +ATOM 2289 H5' G B 71 9.285 3.456 3.496 1.00 1.00 H +ATOM 2290 H5'' G B 71 9.045 5.208 3.664 1.00 1.00 H +ATOM 2291 H4' G B 71 11.178 5.004 4.508 1.00 1.00 H +ATOM 2292 H3' G B 71 11.384 5.538 1.561 1.00 1.00 H +ATOM 2293 H2' G B 71 13.675 5.104 1.506 1.00 1.00 H +ATOM 2294 HO2' G B 71 13.564 6.169 3.986 1.00 1.00 H +ATOM 2295 H1' G B 71 13.822 3.064 3.336 1.00 1.00 H +ATOM 2296 H8 G B 71 10.741 2.276 1.429 1.00 1.00 H +ATOM 2297 H1 G B 71 16.027 1.105 -2.007 1.00 1.00 H +ATOM 2298 H21 G B 71 17.800 1.996 -1.027 1.00 1.00 H +ATOM 2299 H22 G B 71 17.687 2.886 0.482 1.00 1.00 H +ATOM 2300 P U B 72 11.850 8.151 2.144 1.00 1.00 P +ATOM 2301 OP1 U B 72 11.654 9.351 2.989 1.00 1.00 O +ATOM 2302 OP2 U B 72 10.918 7.876 1.027 1.00 1.00 O +ATOM 2303 O5' U B 72 13.348 8.190 1.554 1.00 1.00 O +ATOM 2304 C5' U B 72 14.454 8.471 2.415 1.00 1.00 C +ATOM 2305 C4' U B 72 15.783 8.426 1.665 1.00 1.00 C +ATOM 2306 O4' U B 72 16.049 7.089 1.237 1.00 1.00 O +ATOM 2307 C3' U B 72 15.834 9.306 0.424 1.00 1.00 C +ATOM 2308 O3' U B 72 16.377 10.587 0.763 1.00 1.00 O +ATOM 2309 C2' U B 72 16.791 8.562 -0.489 1.00 1.00 C +ATOM 2310 O2' U B 72 18.147 8.963 -0.265 1.00 1.00 O +ATOM 2311 C1' U B 72 16.574 7.105 -0.098 1.00 1.00 C +ATOM 2312 N1 U B 72 15.610 6.396 -0.961 1.00 1.00 N +ATOM 2313 C2 U B 72 16.106 5.733 -2.067 1.00 1.00 C +ATOM 2314 O2 U B 72 17.305 5.720 -2.338 1.00 1.00 O +ATOM 2315 N3 U B 72 15.174 5.083 -2.855 1.00 1.00 N +ATOM 2316 C4 U B 72 13.807 5.039 -2.636 1.00 1.00 C +ATOM 2317 O4 U B 72 13.068 4.429 -3.406 1.00 1.00 O +ATOM 2318 C5 U B 72 13.377 5.759 -1.458 1.00 1.00 C +ATOM 2319 C6 U B 72 14.272 6.403 -0.671 1.00 1.00 C +ATOM 2320 H5' U B 72 14.475 7.734 3.218 1.00 1.00 H +ATOM 2321 H5'' U B 72 14.325 9.464 2.847 1.00 1.00 H +ATOM 2322 H4' U B 72 16.578 8.732 2.343 1.00 1.00 H +ATOM 2323 H3' U B 72 14.847 9.398 -0.034 1.00 1.00 H +ATOM 2324 H2' U B 72 16.509 8.713 -1.532 1.00 1.00 H +ATOM 2325 HO2' U B 72 18.702 8.416 -0.827 1.00 1.00 H +ATOM 2326 H1' U B 72 17.528 6.581 -0.118 1.00 1.00 H +ATOM 2327 H3 U B 72 15.521 4.593 -3.666 1.00 1.00 H +ATOM 2328 H5 U B 72 12.319 5.785 -1.201 1.00 1.00 H +ATOM 2329 H6 U B 72 13.920 6.939 0.211 1.00 1.00 H +ATOM 2330 P U B 73 15.881 11.922 0.008 1.00 1.00 P +ATOM 2331 OP1 U B 73 16.525 13.085 0.657 1.00 1.00 O +ATOM 2332 OP2 U B 73 14.405 11.865 -0.107 1.00 1.00 O +ATOM 2333 O5' U B 73 16.505 11.763 -1.470 1.00 1.00 O +ATOM 2334 C5' U B 73 17.886 12.055 -1.716 1.00 1.00 C +ATOM 2335 C4' U B 73 18.254 11.839 -3.181 1.00 1.00 C +ATOM 2336 O4' U B 73 18.099 10.461 -3.523 1.00 1.00 O +ATOM 2337 C3' U B 73 17.404 12.626 -4.168 1.00 1.00 C +ATOM 2338 O3' U B 73 17.999 13.906 -4.414 1.00 1.00 O +ATOM 2339 C2' U B 73 17.465 11.767 -5.416 1.00 1.00 C +ATOM 2340 O2' U B 73 18.619 12.073 -6.207 1.00 1.00 O +ATOM 2341 C1' U B 73 17.541 10.358 -4.844 1.00 1.00 C +ATOM 2342 N1 U B 73 16.229 9.690 -4.719 1.00 1.00 N +ATOM 2343 C2 U B 73 15.820 8.879 -5.761 1.00 1.00 C +ATOM 2344 O2 U B 73 16.491 8.738 -6.782 1.00 1.00 O +ATOM 2345 N3 U B 73 14.607 8.236 -5.591 1.00 1.00 N +ATOM 2346 C4 U B 73 13.781 8.332 -4.485 1.00 1.00 C +ATOM 2347 O4 U B 73 12.721 7.710 -4.439 1.00 1.00 O +ATOM 2348 C5 U B 73 14.285 9.201 -3.446 1.00 1.00 C +ATOM 2349 C6 U B 73 15.471 9.841 -3.590 1.00 1.00 C +ATOM 2350 H5' U B 73 18.502 11.405 -1.093 1.00 1.00 H +ATOM 2351 H5'' U B 73 18.082 13.093 -1.450 1.00 1.00 H +ATOM 2352 H4' U B 73 19.298 12.109 -3.324 1.00 1.00 H +ATOM 2353 H3' U B 73 16.376 12.723 -3.807 1.00 1.00 H +ATOM 2354 H2' U B 73 16.553 11.886 -5.999 1.00 1.00 H +ATOM 2355 HO2' U B 73 18.505 11.636 -7.054 1.00 1.00 H +ATOM 2356 H1' U B 73 18.196 9.748 -5.464 1.00 1.00 H +ATOM 2357 H3 U B 73 14.297 7.639 -6.345 1.00 1.00 H +ATOM 2358 H5 U B 73 13.705 9.343 -2.535 1.00 1.00 H +ATOM 2359 H6 U B 73 15.826 10.493 -2.791 1.00 1.00 H +ATOM 2360 P C B 74 17.085 15.174 -4.811 1.00 1.00 P +ATOM 2361 OP1 C B 74 17.985 16.318 -5.085 1.00 1.00 O +ATOM 2362 OP2 C B 74 16.012 15.306 -3.801 1.00 1.00 O +ATOM 2363 O5' C B 74 16.413 14.720 -6.204 1.00 1.00 O +ATOM 2364 C5' C B 74 17.210 14.585 -7.382 1.00 1.00 C +ATOM 2365 C4' C B 74 16.435 13.920 -8.517 1.00 1.00 C +ATOM 2366 O4' C B 74 16.102 12.582 -8.170 1.00 1.00 O +ATOM 2367 C3' C B 74 15.115 14.582 -8.867 1.00 1.00 C +ATOM 2368 O3' C B 74 15.328 15.673 -9.772 1.00 1.00 O +ATOM 2369 C2' C B 74 14.371 13.459 -9.569 1.00 1.00 C +ATOM 2370 O2' C B 74 14.608 13.477 -10.981 1.00 1.00 O +ATOM 2371 C1' C B 74 14.942 12.196 -8.924 1.00 1.00 C +ATOM 2372 N1 C B 74 14.004 11.513 -8.005 1.00 1.00 N +ATOM 2373 C2 C B 74 13.263 10.464 -8.526 1.00 1.00 C +ATOM 2374 O2 C B 74 13.369 10.168 -9.715 1.00 1.00 O +ATOM 2375 N3 C B 74 12.425 9.788 -7.692 1.00 1.00 N +ATOM 2376 C4 C B 74 12.318 10.126 -6.400 1.00 1.00 C +ATOM 2377 N4 C B 74 11.489 9.441 -5.611 1.00 1.00 N +ATOM 2378 C5 C B 74 13.080 11.209 -5.858 1.00 1.00 C +ATOM 2379 C6 C B 74 13.906 11.872 -6.690 1.00 1.00 C +ATOM 2380 H5' C B 74 18.085 13.980 -7.150 1.00 1.00 H +ATOM 2381 H5'' C B 74 17.540 15.573 -7.706 1.00 1.00 H +ATOM 2382 H4' C B 74 17.063 13.895 -9.405 1.00 1.00 H +ATOM 2383 H3' C B 74 14.585 14.903 -7.966 1.00 1.00 H +ATOM 2384 H2' C B 74 13.311 13.526 -9.357 1.00 1.00 H +ATOM 2385 HO2' C B 74 14.166 12.709 -11.350 1.00 1.00 H +ATOM 2386 H1' C B 74 15.248 11.497 -9.704 1.00 1.00 H +ATOM 2387 H41 C B 74 10.951 8.679 -5.987 1.00 1.00 H +ATOM 2388 H42 C B 74 11.400 9.688 -4.634 1.00 1.00 H +ATOM 2389 H5 C B 74 12.997 11.486 -4.806 1.00 1.00 H +ATOM 2390 H6 C B 74 14.503 12.702 -6.312 1.00 1.00 H +ATOM 2391 P U B 75 14.560 17.076 -9.562 1.00 1.00 P +ATOM 2392 OP1 U B 75 15.423 18.151 -10.102 1.00 1.00 O +ATOM 2393 OP2 U B 75 14.101 17.142 -8.156 1.00 1.00 O +ATOM 2394 O5' U B 75 13.256 16.976 -10.512 1.00 1.00 O +ATOM 2395 C5' U B 75 13.376 16.456 -11.842 1.00 1.00 C +ATOM 2396 C4' U B 75 12.265 15.459 -12.196 1.00 1.00 C +ATOM 2397 O4' U B 75 12.259 14.361 -11.291 1.00 1.00 O +ATOM 2398 C3' U B 75 10.851 16.015 -12.161 1.00 1.00 C +ATOM 2399 O3' U B 75 10.542 16.622 -13.421 1.00 1.00 O +ATOM 2400 C2' U B 75 9.998 14.767 -11.975 1.00 1.00 C +ATOM 2401 O2' U B 75 9.504 14.283 -13.228 1.00 1.00 O +ATOM 2402 C1' U B 75 10.952 13.765 -11.321 1.00 1.00 C +ATOM 2403 N1 U B 75 10.571 13.377 -9.943 1.00 1.00 N +ATOM 2404 C2 U B 75 9.817 12.228 -9.802 1.00 1.00 C +ATOM 2405 O2 U B 75 9.462 11.557 -10.770 1.00 1.00 O +ATOM 2406 N3 U B 75 9.485 11.872 -8.508 1.00 1.00 N +ATOM 2407 C4 U B 75 9.836 12.559 -7.357 1.00 1.00 C +ATOM 2408 O4 U B 75 9.485 12.150 -6.253 1.00 1.00 O +ATOM 2409 C5 U B 75 10.622 13.748 -7.598 1.00 1.00 C +ATOM 2410 C6 U B 75 10.959 14.117 -8.858 1.00 1.00 C +ATOM 2411 H5' U B 75 14.339 15.956 -11.937 1.00 1.00 H +ATOM 2412 H5'' U B 75 13.341 17.286 -12.546 1.00 1.00 H +ATOM 2413 H4' U B 75 12.457 15.069 -13.194 1.00 1.00 H +ATOM 2414 H3' U B 75 10.719 16.714 -11.332 1.00 1.00 H +ATOM 2415 H2' U B 75 9.177 14.982 -11.292 1.00 1.00 H +ATOM 2416 HO2' U B 75 9.766 13.363 -13.300 1.00 1.00 H +ATOM 2417 H1' U B 75 10.995 12.872 -11.944 1.00 1.00 H +ATOM 2418 H3 U B 75 8.935 11.034 -8.390 1.00 1.00 H +ATOM 2419 H5 U B 75 10.946 14.357 -6.754 1.00 1.00 H +ATOM 2420 H6 U B 75 11.551 15.018 -9.011 1.00 1.00 H +ATOM 2421 P U B 76 9.375 17.727 -13.558 1.00 1.00 P +ATOM 2422 OP1 U B 76 9.464 18.322 -14.911 1.00 1.00 O +ATOM 2423 OP2 U B 76 9.422 18.601 -12.365 1.00 1.00 O +ATOM 2424 O5' U B 76 8.025 16.846 -13.486 1.00 1.00 O +ATOM 2425 C5' U B 76 7.681 15.947 -14.548 1.00 1.00 C +ATOM 2426 C4' U B 76 6.429 15.133 -14.218 1.00 1.00 C +ATOM 2427 O4' U B 76 6.676 14.280 -13.110 1.00 1.00 O +ATOM 2428 C3' U B 76 5.217 15.967 -13.848 1.00 1.00 C +ATOM 2429 O3' U B 76 4.473 16.282 -15.029 1.00 1.00 O +ATOM 2430 C2' U B 76 4.408 15.045 -12.944 1.00 1.00 C +ATOM 2431 O2' U B 76 3.398 14.348 -13.680 1.00 1.00 O +ATOM 2432 C1' U B 76 5.454 14.077 -12.381 1.00 1.00 C +ATOM 2433 N1 U B 76 5.761 14.300 -10.954 1.00 1.00 N +ATOM 2434 C2 U B 76 5.127 13.507 -10.016 1.00 1.00 C +ATOM 2435 O2 U B 76 4.321 12.637 -10.334 1.00 1.00 O +ATOM 2436 N3 U B 76 5.454 13.751 -8.695 1.00 1.00 N +ATOM 2437 C4 U B 76 6.347 14.705 -8.237 1.00 1.00 C +ATOM 2438 O4 U B 76 6.562 14.835 -7.033 1.00 1.00 O +ATOM 2439 C5 U B 76 6.963 15.486 -9.286 1.00 1.00 C +ATOM 2440 C6 U B 76 6.658 15.266 -10.587 1.00 1.00 C +ATOM 2441 H5' U B 76 8.513 15.265 -14.717 1.00 1.00 H +ATOM 2442 H5'' U B 76 7.500 16.521 -15.457 1.00 1.00 H +ATOM 2443 H4' U B 76 6.179 14.514 -15.076 1.00 1.00 H +ATOM 2444 H3' U B 76 5.516 16.871 -13.314 1.00 1.00 H +ATOM 2445 H2' U B 76 3.963 15.622 -12.130 1.00 1.00 H +ATOM 2446 HO2' U B 76 2.613 14.319 -13.128 1.00 1.00 H +ATOM 2447 H1' U B 76 5.114 13.052 -12.524 1.00 1.00 H +ATOM 2448 H3 U B 76 4.999 13.179 -7.998 1.00 1.00 H +ATOM 2449 H5 U B 76 7.682 16.263 -9.026 1.00 1.00 H +ATOM 2450 H6 U B 76 7.137 15.870 -11.358 1.00 1.00 H +ATOM 2451 P C B 77 3.475 17.544 -15.055 1.00 1.00 P +ATOM 2452 OP1 C B 77 2.756 17.539 -16.348 1.00 1.00 O +ATOM 2453 OP2 C B 77 4.233 18.745 -14.636 1.00 1.00 O +ATOM 2454 O5' C B 77 2.422 17.180 -13.891 1.00 1.00 O +ATOM 2455 C5' C B 77 1.949 18.191 -12.996 1.00 1.00 C +ATOM 2456 C4' C B 77 0.810 17.676 -12.121 1.00 1.00 C +ATOM 2457 O4' C B 77 1.288 16.643 -11.264 1.00 1.00 O +ATOM 2458 C3' C B 77 0.189 18.738 -11.227 1.00 1.00 C +ATOM 2459 O3' C B 77 -0.947 19.311 -11.878 1.00 1.00 O +ATOM 2460 C2' C B 77 -0.261 17.967 -9.995 1.00 1.00 C +ATOM 2461 O2' C B 77 -1.647 17.619 -10.079 1.00 1.00 O +ATOM 2462 C1' C B 77 0.623 16.720 -9.995 1.00 1.00 C +ATOM 2463 N1 C B 77 1.665 16.730 -8.951 1.00 1.00 N +ATOM 2464 C2 C B 77 1.313 16.280 -7.689 1.00 1.00 C +ATOM 2465 O2 C B 77 0.165 15.900 -7.469 1.00 1.00 O +ATOM 2466 N3 C B 77 2.265 16.275 -6.716 1.00 1.00 N +ATOM 2467 C4 C B 77 3.512 16.695 -6.971 1.00 1.00 C +ATOM 2468 N4 C B 77 4.420 16.675 -5.997 1.00 1.00 N +ATOM 2469 C5 C B 77 3.879 17.162 -8.273 1.00 1.00 C +ATOM 2470 C6 C B 77 2.930 17.163 -9.229 1.00 1.00 C +ATOM 2471 H5' C B 77 1.595 19.043 -13.577 1.00 1.00 H +ATOM 2472 H5'' C B 77 2.771 18.512 -12.358 1.00 1.00 H +ATOM 2473 H4' C B 77 0.034 17.260 -12.761 1.00 1.00 H +ATOM 2474 H3' C B 77 0.923 19.500 -10.962 1.00 1.00 H +ATOM 2475 H2' C B 77 -0.067 18.558 -9.096 1.00 1.00 H +ATOM 2476 HO2' C B 77 -1.731 16.942 -10.753 1.00 1.00 H +ATOM 2477 H1' C B 77 -0.002 15.838 -9.865 1.00 1.00 H +ATOM 2478 H41 C B 77 4.165 16.346 -5.075 1.00 1.00 H +ATOM 2479 H42 C B 77 5.363 16.989 -6.178 1.00 1.00 H +ATOM 2480 H5 C B 77 4.893 17.505 -8.484 1.00 1.00 H +ATOM 2481 H6 C B 77 3.174 17.511 -10.232 1.00 1.00 H +ATOM 2482 P C B 78 -1.556 20.712 -11.372 1.00 1.00 P +ATOM 2483 OP1 C B 78 -2.663 21.090 -12.278 1.00 1.00 O +ATOM 2484 OP2 C B 78 -0.433 21.650 -11.147 1.00 1.00 O +ATOM 2485 O5' C B 78 -2.185 20.323 -9.941 1.00 1.00 O +ATOM 2486 C5' C B 78 -2.194 21.269 -8.868 1.00 1.00 C +ATOM 2487 C4' C B 78 -2.984 20.748 -7.669 1.00 1.00 C +ATOM 2488 O4' C B 78 -2.380 19.549 -7.182 1.00 1.00 O +ATOM 2489 C3' C B 78 -3.051 21.723 -6.501 1.00 1.00 C +ATOM 2490 O3' C B 78 -4.272 22.466 -6.563 1.00 1.00 O +ATOM 2491 C2' C B 78 -3.063 20.829 -5.271 1.00 1.00 C +ATOM 2492 O2' C B 78 -4.401 20.578 -4.826 1.00 1.00 O +ATOM 2493 C1' C B 78 -2.388 19.546 -5.748 1.00 1.00 C +ATOM 2494 N1 C B 78 -0.991 19.405 -5.297 1.00 1.00 N +ATOM 2495 C2 C B 78 -0.782 19.066 -3.970 1.00 1.00 C +ATOM 2496 O2 C B 78 -1.740 18.906 -3.218 1.00 1.00 O +ATOM 2497 N3 C B 78 0.500 18.922 -3.535 1.00 1.00 N +ATOM 2498 C4 C B 78 1.533 19.102 -4.369 1.00 1.00 C +ATOM 2499 N4 C B 78 2.776 18.953 -3.911 1.00 1.00 N +ATOM 2500 C5 C B 78 1.321 19.451 -5.740 1.00 1.00 C +ATOM 2501 C6 C B 78 0.049 19.591 -6.159 1.00 1.00 C +ATOM 2502 H5' C B 78 -2.646 22.197 -9.216 1.00 1.00 H +ATOM 2503 H5'' C B 78 -1.167 21.467 -8.559 1.00 1.00 H +ATOM 2504 H4' C B 78 -3.996 20.515 -7.991 1.00 1.00 H +ATOM 2505 H3' C B 78 -2.182 22.383 -6.493 1.00 1.00 H +ATOM 2506 H2' C B 78 -2.471 21.285 -4.475 1.00 1.00 H +ATOM 2507 HO2' C B 78 -4.350 19.928 -4.122 1.00 1.00 H +ATOM 2508 H1' C B 78 -2.962 18.690 -5.395 1.00 1.00 H +ATOM 2509 H41 C B 78 2.934 18.707 -2.943 1.00 1.00 H +ATOM 2510 H42 C B 78 3.562 19.087 -4.532 1.00 1.00 H +ATOM 2511 H5 C B 78 2.160 19.599 -6.421 1.00 1.00 H +ATOM 2512 H6 C B 78 -0.150 19.857 -7.198 1.00 1.00 H +ATOM 2513 P U B 79 -4.471 23.784 -5.659 1.00 1.00 P +ATOM 2514 OP1 U B 79 -5.782 24.382 -5.999 1.00 1.00 O +ATOM 2515 OP2 U B 79 -3.241 24.601 -5.753 1.00 1.00 O +ATOM 2516 O5' U B 79 -4.565 23.181 -4.167 1.00 1.00 O +ATOM 2517 C5' U B 79 -4.226 23.990 -3.036 1.00 1.00 C +ATOM 2518 C4' U B 79 -4.545 23.282 -1.720 1.00 1.00 C +ATOM 2519 O4' U B 79 -3.754 22.099 -1.602 1.00 1.00 O +ATOM 2520 C3' U B 79 -4.277 24.128 -0.482 1.00 1.00 C +ATOM 2521 O3' U B 79 -5.490 24.766 -0.071 1.00 1.00 O +ATOM 2522 C2' U B 79 -3.842 23.117 0.567 1.00 1.00 C +ATOM 2523 O2' U B 79 -4.951 22.681 1.361 1.00 1.00 O +ATOM 2524 C1' U B 79 -3.266 21.969 -0.257 1.00 1.00 C +ATOM 2525 N1 U B 79 -1.792 21.960 -0.321 1.00 1.00 N +ATOM 2526 C2 U B 79 -1.105 21.716 0.852 1.00 1.00 C +ATOM 2527 O2 U B 79 -1.681 21.511 1.918 1.00 1.00 O +ATOM 2528 N3 U B 79 0.275 21.718 0.758 1.00 1.00 N +ATOM 2529 C4 U B 79 1.015 21.939 -0.391 1.00 1.00 C +ATOM 2530 O4 U B 79 2.244 21.916 -0.360 1.00 1.00 O +ATOM 2531 C5 U B 79 0.213 22.187 -1.569 1.00 1.00 C +ATOM 2532 C6 U B 79 -1.139 22.190 -1.502 1.00 1.00 C +ATOM 2533 H5' U B 79 -4.791 24.921 -3.083 1.00 1.00 H +ATOM 2534 H5'' U B 79 -3.162 24.217 -3.067 1.00 1.00 H +ATOM 2535 H4' U B 79 -5.594 22.992 -1.724 1.00 1.00 H +ATOM 2536 H3' U B 79 -3.488 24.857 -0.672 1.00 1.00 H +ATOM 2537 H2' U B 79 -3.062 23.547 1.197 1.00 1.00 H +ATOM 2538 HO2' U B 79 -4.598 22.142 2.071 1.00 1.00 H +ATOM 2539 H1' U B 79 -3.609 21.022 0.159 1.00 1.00 H +ATOM 2540 H3 U B 79 0.791 21.540 1.607 1.00 1.00 H +ATOM 2541 H5 U B 79 0.705 22.372 -2.524 1.00 1.00 H +ATOM 2542 H6 U B 79 -1.719 22.380 -2.405 1.00 1.00 H +ATOM 2543 P A B 80 -5.464 26.213 0.640 1.00 1.00 P +ATOM 2544 OP1 A B 80 -6.861 26.671 0.807 1.00 1.00 O +ATOM 2545 OP2 A B 80 -4.490 27.064 -0.083 1.00 1.00 O +ATOM 2546 O5' A B 80 -4.862 25.887 2.097 1.00 1.00 O +ATOM 2547 C5' A B 80 -5.574 25.040 3.004 1.00 1.00 C +ATOM 2548 C4' A B 80 -4.866 24.941 4.353 1.00 1.00 C +ATOM 2549 O4' A B 80 -3.606 24.288 4.180 1.00 1.00 O +ATOM 2550 C3' A B 80 -4.597 26.288 5.012 1.00 1.00 C +ATOM 2551 O3' A B 80 -4.771 26.169 6.428 1.00 1.00 O +ATOM 2552 C2' A B 80 -3.139 26.578 4.698 1.00 1.00 C +ATOM 2553 O2' A B 80 -2.497 27.254 5.785 1.00 1.00 O +ATOM 2554 C1' A B 80 -2.537 25.197 4.473 1.00 1.00 C +ATOM 2555 N9 A B 80 -1.585 25.137 3.349 1.00 1.00 N +ATOM 2556 C8 A B 80 -1.741 25.594 2.067 1.00 1.00 C +ATOM 2557 N7 A B 80 -0.705 25.386 1.302 1.00 1.00 N +ATOM 2558 C5 A B 80 0.204 24.746 2.138 1.00 1.00 C +ATOM 2559 C6 A B 80 1.503 24.256 1.930 1.00 1.00 C +ATOM 2560 N6 A B 80 2.137 24.342 0.760 1.00 1.00 N +ATOM 2561 N1 A B 80 2.119 23.677 2.975 1.00 1.00 N +ATOM 2562 C2 A B 80 1.482 23.594 4.137 1.00 1.00 C +ATOM 2563 N3 A B 80 0.266 24.013 4.456 1.00 1.00 N +ATOM 2564 C4 A B 80 -0.325 24.589 3.388 1.00 1.00 C +ATOM 2565 H5' A B 80 -5.655 24.044 2.571 1.00 1.00 H +ATOM 2566 H5'' A B 80 -6.575 25.445 3.158 1.00 1.00 H +ATOM 2567 H4' A B 80 -5.475 24.338 5.025 1.00 1.00 H +ATOM 2568 H3' A B 80 -5.246 27.061 4.597 1.00 1.00 H +ATOM 2569 H2' A B 80 -3.066 27.169 3.781 1.00 1.00 H +ATOM 2570 HO2' A B 80 -2.793 26.836 6.597 1.00 1.00 H +ATOM 2571 H1' A B 80 -2.032 24.873 5.383 1.00 1.00 H +ATOM 2572 H8 A B 80 -2.649 26.087 1.717 1.00 1.00 H +ATOM 2573 H61 A B 80 3.072 23.973 0.663 1.00 1.00 H +ATOM 2574 H62 A B 80 1.680 24.775 -0.031 1.00 1.00 H +ATOM 2575 H2 A B 80 2.039 23.112 4.942 1.00 1.00 H +ATOM 2576 P A B 81 -5.073 27.467 7.329 1.00 1.00 P +ATOM 2577 OP1 A B 81 -6.432 27.953 7.002 1.00 1.00 O +ATOM 2578 OP2 A B 81 -3.917 28.384 7.225 1.00 1.00 O +ATOM 2579 O5' A B 81 -5.102 26.861 8.820 1.00 1.00 O +ATOM 2580 C5' A B 81 -6.279 26.228 9.330 1.00 1.00 C +ATOM 2581 C4' A B 81 -5.940 25.163 10.368 1.00 1.00 C +ATOM 2582 O4' A B 81 -5.654 23.927 9.707 1.00 1.00 O +ATOM 2583 C3' A B 81 -4.735 25.512 11.232 1.00 1.00 C +ATOM 2584 O3' A B 81 -5.178 26.024 12.493 1.00 1.00 O +ATOM 2585 C2' A B 81 -4.028 24.183 11.444 1.00 1.00 C +ATOM 2586 O2' A B 81 -4.439 23.565 12.669 1.00 1.00 O +ATOM 2587 C1' A B 81 -4.451 23.357 10.236 1.00 1.00 C +ATOM 2588 N9 A B 81 -3.455 23.332 9.149 1.00 1.00 N +ATOM 2589 C8 A B 81 -3.475 23.996 7.950 1.00 1.00 C +ATOM 2590 N7 A B 81 -2.435 23.758 7.198 1.00 1.00 N +ATOM 2591 C5 A B 81 -1.673 22.873 7.956 1.00 1.00 C +ATOM 2592 C6 A B 81 -0.442 22.239 7.719 1.00 1.00 C +ATOM 2593 N6 A B 81 0.264 22.409 6.601 1.00 1.00 N +ATOM 2594 N1 A B 81 0.026 21.426 8.681 1.00 1.00 N +ATOM 2595 C2 A B 81 -0.681 21.261 9.792 1.00 1.00 C +ATOM 2596 N3 A B 81 -1.843 21.800 10.129 1.00 1.00 N +ATOM 2597 C4 A B 81 -2.287 22.609 9.146 1.00 1.00 C +ATOM 2598 H5' A B 81 -6.818 25.762 8.504 1.00 1.00 H +ATOM 2599 H5'' A B 81 -6.917 26.984 9.791 1.00 1.00 H +ATOM 2600 H4' A B 81 -6.803 25.015 11.013 1.00 1.00 H +ATOM 2601 H3' A B 81 -4.083 26.223 10.724 1.00 1.00 H +ATOM 2602 H2' A B 81 -2.946 24.333 11.432 1.00 1.00 H +ATOM 2603 HO2' A B 81 -4.067 22.679 12.679 1.00 1.00 H +ATOM 2604 H1' A B 81 -4.652 22.335 10.556 1.00 1.00 H +ATOM 2605 H8 A B 81 -4.286 24.659 7.649 1.00 1.00 H +ATOM 2606 H61 A B 81 1.144 21.928 6.481 1.00 1.00 H +ATOM 2607 H62 A B 81 -0.081 23.019 5.874 1.00 1.00 H +ATOM 2608 H2 A B 81 -0.245 20.588 10.530 1.00 1.00 H +ATOM 2609 P G B 82 -4.124 26.658 13.532 1.00 1.00 P +ATOM 2610 OP1 G B 82 -4.838 27.637 14.381 1.00 1.00 O +ATOM 2611 OP2 G B 82 -2.924 27.078 12.772 1.00 1.00 O +ATOM 2612 O5' G B 82 -3.724 25.393 14.443 1.00 1.00 O +ATOM 2613 C5' G B 82 -2.417 25.295 15.015 1.00 1.00 C +ATOM 2614 C4' G B 82 -1.736 23.986 14.630 1.00 1.00 C +ATOM 2615 O4' G B 82 -1.919 23.748 13.233 1.00 1.00 O +ATOM 2616 C3' G B 82 -0.237 23.966 14.909 1.00 1.00 C +ATOM 2617 O3' G B 82 0.011 23.269 16.134 1.00 1.00 O +ATOM 2618 C2' G B 82 0.345 23.182 13.744 1.00 1.00 C +ATOM 2619 O2' G B 82 0.477 21.793 14.065 1.00 1.00 O +ATOM 2620 C1' G B 82 -0.670 23.399 12.629 1.00 1.00 C +ATOM 2621 N9 G B 82 -0.311 24.483 11.695 1.00 1.00 N +ATOM 2622 C8 G B 82 -0.756 25.780 11.674 1.00 1.00 C +ATOM 2623 N7 G B 82 -0.248 26.496 10.711 1.00 1.00 N +ATOM 2624 C5 G B 82 0.593 25.613 10.042 1.00 1.00 C +ATOM 2625 C6 G B 82 1.418 25.826 8.903 1.00 1.00 C +ATOM 2626 O6 G B 82 1.569 26.857 8.251 1.00 1.00 O +ATOM 2627 N1 G B 82 2.106 24.673 8.550 1.00 1.00 N +ATOM 2628 C2 G B 82 2.014 23.465 9.207 1.00 1.00 C +ATOM 2629 N2 G B 82 2.753 22.469 8.718 1.00 1.00 N +ATOM 2630 N3 G B 82 1.240 23.262 10.278 1.00 1.00 N +ATOM 2631 C4 G B 82 0.561 24.377 10.638 1.00 1.00 C +ATOM 2632 H5' G B 82 -2.498 25.349 16.100 1.00 1.00 H +ATOM 2633 H5'' G B 82 -1.810 26.129 14.661 1.00 1.00 H +ATOM 2634 H4' G B 82 -2.206 23.173 15.181 1.00 1.00 H +ATOM 2635 H3' G B 82 0.166 24.980 14.939 1.00 1.00 H +ATOM 2636 H2' G B 82 1.309 23.606 13.455 1.00 1.00 H +ATOM 2637 HO2' G B 82 -0.278 21.339 13.684 1.00 1.00 H +ATOM 2638 H1' G B 82 -0.789 22.473 12.069 1.00 1.00 H +ATOM 2639 H8 G B 82 -1.470 26.175 12.396 1.00 1.00 H +ATOM 2640 H1 G B 82 2.715 24.746 7.747 1.00 1.00 H +ATOM 2641 H21 G B 82 3.336 22.625 7.908 1.00 1.00 H +ATOM 2642 H22 G B 82 2.728 21.559 9.155 1.00 1.00 H +ATOM 2643 P U B 83 1.001 23.889 17.244 1.00 1.00 P +ATOM 2644 OP1 U B 83 1.111 22.920 18.357 1.00 1.00 O +ATOM 2645 OP2 U B 83 0.575 25.280 17.516 1.00 1.00 O +ATOM 2646 O5' U B 83 2.414 23.937 16.476 1.00 1.00 O +ATOM 2647 C5' U B 83 3.250 22.778 16.415 1.00 1.00 C +ATOM 2648 C4' U B 83 4.516 23.045 15.607 1.00 1.00 C +ATOM 2649 O4' U B 83 4.177 23.248 14.237 1.00 1.00 O +ATOM 2650 C3' U B 83 5.290 24.274 16.060 1.00 1.00 C +ATOM 2651 O3' U B 83 6.293 23.888 17.006 1.00 1.00 O +ATOM 2652 C2' U B 83 5.942 24.774 14.781 1.00 1.00 C +ATOM 2653 O2' U B 83 7.252 24.220 14.614 1.00 1.00 O +ATOM 2654 C1' U B 83 4.994 24.290 13.684 1.00 1.00 C +ATOM 2655 N1 U B 83 4.086 25.336 13.168 1.00 1.00 N +ATOM 2656 C2 U B 83 4.475 26.022 12.033 1.00 1.00 C +ATOM 2657 O2 U B 83 5.535 25.785 11.457 1.00 1.00 O +ATOM 2658 N3 U B 83 3.602 26.994 11.580 1.00 1.00 N +ATOM 2659 C4 U B 83 2.389 27.335 12.156 1.00 1.00 C +ATOM 2660 O4 U B 83 1.690 28.219 11.666 1.00 1.00 O +ATOM 2661 C5 U B 83 2.062 26.568 13.337 1.00 1.00 C +ATOM 2662 C6 U B 83 2.903 25.610 13.799 1.00 1.00 C +ATOM 2663 H5' U B 83 2.696 21.964 15.948 1.00 1.00 H +ATOM 2664 H5'' U B 83 3.529 22.485 17.427 1.00 1.00 H +ATOM 2665 H4' U B 83 5.166 22.175 15.674 1.00 1.00 H +ATOM 2666 H3' U B 83 4.617 25.027 16.476 1.00 1.00 H +ATOM 2667 H2' U B 83 5.981 25.866 14.785 1.00 1.00 H +ATOM 2668 HO2' U B 83 7.842 24.701 15.197 1.00 1.00 H +ATOM 2669 H1' U B 83 5.580 23.883 12.860 1.00 1.00 H +ATOM 2670 H3 U B 83 3.874 27.503 10.751 1.00 1.00 H +ATOM 2671 H5 U B 83 1.129 26.763 13.864 1.00 1.00 H +ATOM 2672 H6 U B 83 2.631 25.046 14.692 1.00 1.00 H +ATOM 2673 P C B 84 6.521 24.741 18.355 1.00 1.00 P +ATOM 2674 OP1 C B 84 7.476 24.003 19.212 1.00 1.00 O +ATOM 2675 OP2 C B 84 5.194 25.122 18.889 1.00 1.00 O +ATOM 2676 O5' C B 84 7.251 26.074 17.821 1.00 1.00 O +ATOM 2677 C5' C B 84 8.595 26.019 17.333 1.00 1.00 C +ATOM 2678 C4' C B 84 8.925 27.219 16.448 1.00 1.00 C +ATOM 2679 O4' C B 84 8.014 27.287 15.357 1.00 1.00 O +ATOM 2680 C3' C B 84 8.845 28.566 17.150 1.00 1.00 C +ATOM 2681 O3' C B 84 10.120 28.898 17.714 1.00 1.00 O +ATOM 2682 C2' C B 84 8.521 29.534 16.024 1.00 1.00 C +ATOM 2683 O2' C B 84 9.698 30.194 15.545 1.00 1.00 O +ATOM 2684 C1' C B 84 7.894 28.654 14.944 1.00 1.00 C +ATOM 2685 N1 C B 84 6.466 28.947 14.693 1.00 1.00 N +ATOM 2686 C2 C B 84 6.177 29.845 13.678 1.00 1.00 C +ATOM 2687 O2 C B 84 7.087 30.361 13.034 1.00 1.00 O +ATOM 2688 N3 C B 84 4.869 30.133 13.425 1.00 1.00 N +ATOM 2689 C4 C B 84 3.889 29.564 14.138 1.00 1.00 C +ATOM 2690 N4 C B 84 2.620 29.866 13.864 1.00 1.00 N +ATOM 2691 C5 C B 84 4.185 28.636 15.186 1.00 1.00 C +ATOM 2692 C6 C B 84 5.480 28.357 15.428 1.00 1.00 C +ATOM 2693 H5' C B 84 8.725 25.106 16.755 1.00 1.00 H +ATOM 2694 H5'' C B 84 9.280 26.003 18.180 1.00 1.00 H +ATOM 2695 H4' C B 84 9.927 27.091 16.046 1.00 1.00 H +ATOM 2696 H3' C B 84 8.059 28.568 17.908 1.00 1.00 H +ATOM 2697 H2' C B 84 7.784 30.262 16.369 1.00 1.00 H +ATOM 2698 HO2' C B 84 10.226 29.536 15.089 1.00 1.00 H +ATOM 2699 H1' C B 84 8.453 28.786 14.017 1.00 1.00 H +ATOM 2700 H41 C B 84 2.406 30.523 13.123 1.00 1.00 H +ATOM 2701 H42 C B 84 1.872 29.443 14.396 1.00 1.00 H +ATOM 2702 H5 C B 84 3.388 28.170 15.767 1.00 1.00 H +ATOM 2703 H6 C B 84 5.742 27.655 16.220 1.00 1.00 H +ATOM 2704 P C B 85 10.254 30.080 18.803 1.00 1.00 P +ATOM 2705 OP1 C B 85 11.424 29.785 19.660 1.00 1.00 O +ATOM 2706 OP2 C B 85 8.924 30.293 19.418 1.00 1.00 O +ATOM 2707 O5' C B 85 10.604 31.371 17.898 1.00 1.00 O +ATOM 2708 C5' C B 85 11.869 31.480 17.236 1.00 1.00 C +ATOM 2709 C4' C B 85 11.880 32.617 16.214 1.00 1.00 C +ATOM 2710 O4' C B 85 10.841 32.424 15.254 1.00 1.00 O +ATOM 2711 C3' C B 85 11.663 34.003 16.805 1.00 1.00 C +ATOM 2712 O3' C B 85 12.923 34.585 17.160 1.00 1.00 O +ATOM 2713 C2' C B 85 11.039 34.779 15.658 1.00 1.00 C +ATOM 2714 O2' C B 85 12.034 35.438 14.867 1.00 1.00 O +ATOM 2715 C1' C B 85 10.316 33.702 14.857 1.00 1.00 C +ATOM 2716 N1 C B 85 8.859 33.672 15.084 1.00 1.00 N +ATOM 2717 C2 C B 85 8.077 34.530 14.329 1.00 1.00 C +ATOM 2718 O2 C B 85 8.602 35.287 13.514 1.00 1.00 O +ATOM 2719 N3 C B 85 6.728 34.510 14.518 1.00 1.00 N +ATOM 2720 C4 C B 85 6.172 33.680 15.412 1.00 1.00 C +ATOM 2721 N4 C B 85 4.848 33.686 15.575 1.00 1.00 N +ATOM 2722 C5 C B 85 6.978 32.792 16.192 1.00 1.00 C +ATOM 2723 C6 C B 85 8.309 32.820 15.996 1.00 1.00 C +ATOM 2724 H5' C B 85 12.082 30.541 16.724 1.00 1.00 H +ATOM 2725 H5'' C B 85 12.646 31.663 17.979 1.00 1.00 H +ATOM 2726 H4' C B 85 12.833 32.607 15.690 1.00 1.00 H +ATOM 2727 H3' C B 85 10.988 33.961 17.661 1.00 1.00 H +ATOM 2728 H2' C B 85 10.315 35.497 16.046 1.00 1.00 H +ATOM 2729 HO2' C B 85 12.639 34.766 14.549 1.00 1.00 H +ATOM 2730 H1' C B 85 10.508 33.854 13.795 1.00 1.00 H +ATOM 2731 H41 C B 85 4.275 34.309 15.027 1.00 1.00 H +ATOM 2732 H42 C B 85 4.420 33.064 16.246 1.00 1.00 H +ATOM 2733 H5 C B 85 6.528 32.116 16.920 1.00 1.00 H +ATOM 2734 H6 C B 85 8.954 32.157 16.574 1.00 1.00 H +ATOM 2735 P U B 86 12.995 35.792 18.225 1.00 1.00 P +ATOM 2736 OP1 U B 86 14.403 36.237 18.324 1.00 1.00 O +ATOM 2737 OP2 U B 86 12.264 35.378 19.444 1.00 1.00 O +ATOM 2738 O5' U B 86 12.147 36.953 17.496 1.00 1.00 O +ATOM 2739 C5' U B 86 12.604 37.521 16.263 1.00 1.00 C +ATOM 2740 C4' U B 86 11.618 38.552 15.714 1.00 1.00 C +ATOM 2741 O4' U B 86 10.372 37.928 15.430 1.00 1.00 O +ATOM 2742 C3' U B 86 11.313 39.698 16.665 1.00 1.00 C +ATOM 2743 O3' U B 86 12.231 40.783 16.486 1.00 1.00 O +ATOM 2744 C2' U B 86 9.888 40.105 16.293 1.00 1.00 C +ATOM 2745 O2' U B 86 9.879 41.298 15.504 1.00 1.00 O +ATOM 2746 C1' U B 86 9.341 38.916 15.506 1.00 1.00 C +ATOM 2747 N1 U B 86 8.154 38.292 16.128 1.00 1.00 N +ATOM 2748 C2 U B 86 6.911 38.738 15.719 1.00 1.00 C +ATOM 2749 O2 U B 86 6.780 39.616 14.871 1.00 1.00 O +ATOM 2750 N3 U B 86 5.822 38.139 16.324 1.00 1.00 N +ATOM 2751 C4 U B 86 5.865 37.148 17.290 1.00 1.00 C +ATOM 2752 O4 U B 86 4.828 36.686 17.760 1.00 1.00 O +ATOM 2753 C5 U B 86 7.204 36.744 17.657 1.00 1.00 C +ATOM 2754 C6 U B 86 8.287 37.315 17.078 1.00 1.00 C +ATOM 2755 H5' U B 86 12.729 36.726 15.530 1.00 1.00 H +ATOM 2756 H5'' U B 86 13.566 38.006 16.430 1.00 1.00 H +ATOM 2757 H4' U B 86 12.016 38.959 14.787 1.00 1.00 H +ATOM 2758 H3' U B 86 11.339 39.339 17.698 1.00 1.00 H +ATOM 2759 HO3' U B 86 13.109 40.452 16.694 1.00 1.00 H +ATOM 2760 H2' U B 86 9.293 40.241 17.198 1.00 1.00 H +ATOM 2761 HO2' U B 86 9.239 41.896 15.898 1.00 1.00 H +ATOM 2762 H1' U B 86 9.088 39.243 14.497 1.00 1.00 H +ATOM 2763 H3 U B 86 4.906 38.456 16.036 1.00 1.00 H +ATOM 2764 H5 U B 86 7.342 35.970 18.413 1.00 1.00 H +ATOM 2765 H6 U B 86 9.285 36.991 17.374 1.00 1.00 H +TER 2766 U B 86 +ENDMDL +MODEL 4 +ATOM 1 O5' G A 1 4.637 -41.115 5.618 1.00 1.00 O +ATOM 2 C5' G A 1 5.515 -41.964 4.874 1.00 1.00 C +ATOM 3 C4' G A 1 4.795 -42.602 3.686 1.00 1.00 C +ATOM 4 O4' G A 1 3.955 -43.667 4.149 1.00 1.00 O +ATOM 5 C3' G A 1 3.917 -41.627 2.905 1.00 1.00 C +ATOM 6 O3' G A 1 4.574 -41.254 1.690 1.00 1.00 O +ATOM 7 C2' G A 1 2.665 -42.427 2.584 1.00 1.00 C +ATOM 8 O2' G A 1 2.770 -43.074 1.311 1.00 1.00 O +ATOM 9 C1' G A 1 2.610 -43.439 3.717 1.00 1.00 C +ATOM 10 N9 G A 1 1.843 -42.983 4.887 1.00 1.00 N +ATOM 11 C8 G A 1 2.303 -42.657 6.137 1.00 1.00 C +ATOM 12 N7 G A 1 1.367 -42.278 6.963 1.00 1.00 N +ATOM 13 C5 G A 1 0.201 -42.358 6.207 1.00 1.00 C +ATOM 14 C6 G A 1 -1.143 -42.069 6.573 1.00 1.00 C +ATOM 15 O6 G A 1 -1.571 -41.676 7.655 1.00 1.00 O +ATOM 16 N1 G A 1 -2.016 -42.282 5.514 1.00 1.00 N +ATOM 17 C2 G A 1 -1.645 -42.719 4.259 1.00 1.00 C +ATOM 18 N2 G A 1 -2.628 -42.866 3.371 1.00 1.00 N +ATOM 19 N3 G A 1 -0.383 -42.992 3.914 1.00 1.00 N +ATOM 20 C4 G A 1 0.483 -42.789 4.936 1.00 1.00 C +ATOM 21 H5' G A 1 5.895 -42.746 5.535 1.00 1.00 H +ATOM 22 H5'' G A 1 6.352 -41.379 4.502 1.00 1.00 H +ATOM 23 H4' G A 1 5.539 -43.022 3.011 1.00 1.00 H +ATOM 24 H3' G A 1 3.674 -40.752 3.510 1.00 1.00 H +ATOM 25 H2' G A 1 1.788 -41.779 2.619 1.00 1.00 H +ATOM 26 HO2' G A 1 3.666 -43.409 1.234 1.00 1.00 H +ATOM 27 H1' G A 1 2.185 -44.372 3.349 1.00 1.00 H +ATOM 28 H8 G A 1 3.355 -42.709 6.416 1.00 1.00 H +ATOM 29 H1 G A 1 -2.991 -42.097 5.698 1.00 1.00 H +ATOM 30 H21 G A 1 -3.581 -42.659 3.632 1.00 1.00 H +ATOM 31 H22 G A 1 -2.418 -43.183 2.435 1.00 1.00 H +ATOM 32 HO5' G A 1 4.666 -41.406 6.534 1.00 1.00 H +ATOM 33 P G A 2 4.369 -39.779 1.075 1.00 1.00 P +ATOM 34 OP1 G A 2 5.017 -39.737 -0.254 1.00 1.00 O +ATOM 35 OP2 G A 2 4.740 -38.790 2.111 1.00 1.00 O +ATOM 36 O5' G A 2 2.775 -39.708 0.861 1.00 1.00 O +ATOM 37 C5' G A 2 2.129 -40.551 -0.095 1.00 1.00 C +ATOM 38 C4' G A 2 0.618 -40.341 -0.090 1.00 1.00 C +ATOM 39 O4' G A 2 0.062 -40.782 1.144 1.00 1.00 O +ATOM 40 C3' G A 2 0.189 -38.893 -0.261 1.00 1.00 C +ATOM 41 O3' G A 2 0.034 -38.595 -1.654 1.00 1.00 O +ATOM 42 C2' G A 2 -1.158 -38.839 0.442 1.00 1.00 C +ATOM 43 O2' G A 2 -2.238 -38.972 -0.487 1.00 1.00 O +ATOM 44 C1' G A 2 -1.112 -40.008 1.422 1.00 1.00 C +ATOM 45 N9 G A 2 -1.065 -39.586 2.828 1.00 1.00 N +ATOM 46 C8 G A 2 0.008 -39.517 3.679 1.00 1.00 C +ATOM 47 N7 G A 2 -0.298 -39.124 4.885 1.00 1.00 N +ATOM 48 C5 G A 2 -1.673 -38.915 4.832 1.00 1.00 C +ATOM 49 C6 G A 2 -2.570 -38.480 5.846 1.00 1.00 C +ATOM 50 O6 G A 2 -2.319 -38.187 7.013 1.00 1.00 O +ATOM 51 N1 G A 2 -3.874 -38.401 5.374 1.00 1.00 N +ATOM 52 C2 G A 2 -4.269 -38.705 4.088 1.00 1.00 C +ATOM 53 N2 G A 2 -5.567 -38.569 3.820 1.00 1.00 N +ATOM 54 N3 G A 2 -3.427 -39.115 3.133 1.00 1.00 N +ATOM 55 C4 G A 2 -2.151 -39.196 3.575 1.00 1.00 C +ATOM 56 H5' G A 2 2.342 -41.593 0.146 1.00 1.00 H +ATOM 57 H5'' G A 2 2.517 -40.327 -1.088 1.00 1.00 H +ATOM 58 H4' G A 2 0.181 -40.932 -0.893 1.00 1.00 H +ATOM 59 H3' G A 2 0.904 -38.218 0.214 1.00 1.00 H +ATOM 60 H2' G A 2 -1.243 -37.908 1.000 1.00 1.00 H +ATOM 61 HO2' G A 2 -2.702 -38.131 -0.504 1.00 1.00 H +ATOM 62 H1' G A 2 -1.994 -40.632 1.276 1.00 1.00 H +ATOM 63 H8 G A 2 1.025 -39.769 3.376 1.00 1.00 H +ATOM 64 H1 G A 2 -4.570 -38.098 6.039 1.00 1.00 H +ATOM 65 H21 G A 2 -6.202 -38.259 4.543 1.00 1.00 H +ATOM 66 H22 G A 2 -5.917 -38.776 2.896 1.00 1.00 H +ATOM 67 P G A 3 0.129 -37.078 -2.188 1.00 1.00 P +ATOM 68 OP1 G A 3 0.487 -37.115 -3.624 1.00 1.00 O +ATOM 69 OP2 G A 3 0.961 -36.306 -1.239 1.00 1.00 O +ATOM 70 O5' G A 3 -1.392 -36.560 -2.062 1.00 1.00 O +ATOM 71 C5' G A 3 -2.432 -37.160 -2.840 1.00 1.00 C +ATOM 72 C4' G A 3 -3.815 -36.755 -2.334 1.00 1.00 C +ATOM 73 O4' G A 3 -3.914 -37.029 -0.938 1.00 1.00 O +ATOM 74 C3' G A 3 -4.140 -35.280 -2.522 1.00 1.00 C +ATOM 75 O3' G A 3 -4.821 -35.097 -3.771 1.00 1.00 O +ATOM 76 C2' G A 3 -5.076 -34.975 -1.362 1.00 1.00 C +ATOM 77 O2' G A 3 -6.446 -35.157 -1.733 1.00 1.00 O +ATOM 78 C1' G A 3 -4.649 -35.978 -0.293 1.00 1.00 C +ATOM 79 N9 G A 3 -3.782 -35.403 0.746 1.00 1.00 N +ATOM 80 C8 G A 3 -2.418 -35.473 0.868 1.00 1.00 C +ATOM 81 N7 G A 3 -1.952 -34.892 1.938 1.00 1.00 N +ATOM 82 C5 G A 3 -3.089 -34.399 2.573 1.00 1.00 C +ATOM 83 C6 G A 3 -3.208 -33.670 3.789 1.00 1.00 C +ATOM 84 O6 G A 3 -2.317 -33.314 4.556 1.00 1.00 O +ATOM 85 N1 G A 3 -4.533 -33.363 4.069 1.00 1.00 N +ATOM 86 C2 G A 3 -5.610 -33.712 3.282 1.00 1.00 C +ATOM 87 N2 G A 3 -6.808 -33.325 3.716 1.00 1.00 N +ATOM 88 N3 G A 3 -5.500 -34.399 2.140 1.00 1.00 N +ATOM 89 C4 G A 3 -4.214 -34.706 1.849 1.00 1.00 C +ATOM 90 H5' G A 3 -2.336 -38.245 -2.786 1.00 1.00 H +ATOM 91 H5'' G A 3 -2.326 -36.844 -3.878 1.00 1.00 H +ATOM 92 H4' G A 3 -4.564 -37.348 -2.855 1.00 1.00 H +ATOM 93 H3' G A 3 -3.237 -34.671 -2.466 1.00 1.00 H +ATOM 94 H2' G A 3 -4.904 -33.959 -1.002 1.00 1.00 H +ATOM 95 HO2' G A 3 -6.461 -35.392 -2.664 1.00 1.00 H +ATOM 96 H1' G A 3 -5.535 -36.401 0.185 1.00 1.00 H +ATOM 97 H8 G A 3 -1.780 -35.968 0.136 1.00 1.00 H +ATOM 98 H1 G A 3 -4.699 -32.846 4.921 1.00 1.00 H +ATOM 99 H21 G A 3 -6.889 -32.806 4.582 1.00 1.00 H +ATOM 100 H22 G A 3 -7.636 -33.552 3.184 1.00 1.00 H +ATOM 101 P A A 4 -4.687 -33.716 -4.593 1.00 1.00 P +ATOM 102 OP1 A A 4 -5.318 -33.905 -5.919 1.00 1.00 O +ATOM 103 OP2 A A 4 -3.282 -33.261 -4.506 1.00 1.00 O +ATOM 104 O5' A A 4 -5.597 -32.695 -3.744 1.00 1.00 O +ATOM 105 C5' A A 4 -7.023 -32.822 -3.739 1.00 1.00 C +ATOM 106 C4' A A 4 -7.668 -31.821 -2.784 1.00 1.00 C +ATOM 107 O4' A A 4 -7.316 -32.135 -1.440 1.00 1.00 O +ATOM 108 C3' A A 4 -7.248 -30.381 -3.021 1.00 1.00 C +ATOM 109 O3' A A 4 -8.149 -29.761 -3.944 1.00 1.00 O +ATOM 110 C2' A A 4 -7.385 -29.745 -1.646 1.00 1.00 C +ATOM 111 O2' A A 4 -8.678 -29.151 -1.474 1.00 1.00 O +ATOM 112 C1' A A 4 -7.181 -30.921 -0.688 1.00 1.00 C +ATOM 113 N9 A A 4 -5.854 -30.950 -0.050 1.00 1.00 N +ATOM 114 C8 A A 4 -4.665 -31.394 -0.566 1.00 1.00 C +ATOM 115 N7 A A 4 -3.659 -31.291 0.259 1.00 1.00 N +ATOM 116 C5 A A 4 -4.225 -30.739 1.404 1.00 1.00 C +ATOM 117 C6 A A 4 -3.684 -30.381 2.650 1.00 1.00 C +ATOM 118 N6 A A 4 -2.394 -30.532 2.956 1.00 1.00 N +ATOM 119 N1 A A 4 -4.524 -29.860 3.559 1.00 1.00 N +ATOM 120 C2 A A 4 -5.806 -29.711 3.247 1.00 1.00 C +ATOM 121 N3 A A 4 -6.431 -30.008 2.118 1.00 1.00 N +ATOM 122 C4 A A 4 -5.562 -30.528 1.225 1.00 1.00 C +ATOM 123 H5' A A 4 -7.290 -33.833 -3.430 1.00 1.00 H +ATOM 124 H5'' A A 4 -7.398 -32.646 -4.747 1.00 1.00 H +ATOM 125 H4' A A 4 -8.749 -31.892 -2.881 1.00 1.00 H +ATOM 126 H3' A A 4 -6.215 -30.330 -3.374 1.00 1.00 H +ATOM 127 H2' A A 4 -6.596 -29.004 -1.498 1.00 1.00 H +ATOM 128 HO2' A A 4 -9.101 -29.594 -0.737 1.00 1.00 H +ATOM 129 H1' A A 4 -7.947 -30.892 0.086 1.00 1.00 H +ATOM 130 H8 A A 4 -4.567 -31.797 -1.575 1.00 1.00 H +ATOM 131 H61 A A 4 -2.056 -30.257 3.865 1.00 1.00 H +ATOM 132 H62 A A 4 -1.756 -30.922 2.277 1.00 1.00 H +ATOM 133 H2 A A 4 -6.431 -29.283 4.031 1.00 1.00 H +ATOM 134 P U A 5 -7.629 -28.661 -4.999 1.00 1.00 P +ATOM 135 OP1 U A 5 -8.778 -28.243 -5.833 1.00 1.00 O +ATOM 136 OP2 U A 5 -6.402 -29.181 -5.642 1.00 1.00 O +ATOM 137 O5' U A 5 -7.217 -27.423 -4.054 1.00 1.00 O +ATOM 138 C5' U A 5 -8.203 -26.749 -3.269 1.00 1.00 C +ATOM 139 C4' U A 5 -7.562 -25.935 -2.146 1.00 1.00 C +ATOM 140 O4' U A 5 -6.849 -26.801 -1.270 1.00 1.00 O +ATOM 141 C3' U A 5 -6.569 -24.890 -2.626 1.00 1.00 C +ATOM 142 O3' U A 5 -7.247 -23.641 -2.805 1.00 1.00 O +ATOM 143 C2' U A 5 -5.574 -24.777 -1.477 1.00 1.00 C +ATOM 144 O2' U A 5 -5.879 -23.658 -0.637 1.00 1.00 O +ATOM 145 C1' U A 5 -5.722 -26.103 -0.722 1.00 1.00 C +ATOM 146 N1 U A 5 -4.544 -26.995 -0.832 1.00 1.00 N +ATOM 147 C2 U A 5 -3.646 -27.001 0.219 1.00 1.00 C +ATOM 148 O2 U A 5 -3.802 -26.301 1.217 1.00 1.00 O +ATOM 149 N3 U A 5 -2.559 -27.845 0.082 1.00 1.00 N +ATOM 150 C4 U A 5 -2.296 -28.671 -0.998 1.00 1.00 C +ATOM 151 O4 U A 5 -1.293 -29.383 -1.013 1.00 1.00 O +ATOM 152 C5 U A 5 -3.287 -28.599 -2.048 1.00 1.00 C +ATOM 153 C6 U A 5 -4.360 -27.780 -1.937 1.00 1.00 C +ATOM 154 H5' U A 5 -8.878 -27.487 -2.834 1.00 1.00 H +ATOM 155 H5'' U A 5 -8.773 -26.079 -3.913 1.00 1.00 H +ATOM 156 H4' U A 5 -8.347 -25.441 -1.577 1.00 1.00 H +ATOM 157 H3' U A 5 -6.075 -25.211 -3.544 1.00 1.00 H +ATOM 158 H2' U A 5 -4.560 -24.690 -1.875 1.00 1.00 H +ATOM 159 HO2' U A 5 -5.113 -23.082 -0.639 1.00 1.00 H +ATOM 160 H1' U A 5 -5.918 -25.894 0.332 1.00 1.00 H +ATOM 161 H3 U A 5 -1.893 -27.861 0.842 1.00 1.00 H +ATOM 162 H5 U A 5 -3.168 -29.212 -2.941 1.00 1.00 H +ATOM 163 H6 U A 5 -5.093 -27.747 -2.743 1.00 1.00 H +ATOM 164 P A A 6 -7.111 -22.817 -4.181 1.00 1.00 P +ATOM 165 OP1 A A 6 -7.163 -23.781 -5.304 1.00 1.00 O +ATOM 166 OP2 A A 6 -5.963 -21.891 -4.057 1.00 1.00 O +ATOM 167 O5' A A 6 -8.465 -21.946 -4.201 1.00 1.00 O +ATOM 168 C5' A A 6 -8.442 -20.557 -3.861 1.00 1.00 C +ATOM 169 C4' A A 6 -8.423 -20.350 -2.347 1.00 1.00 C +ATOM 170 O4' A A 6 -7.208 -20.885 -1.818 1.00 1.00 O +ATOM 171 C3' A A 6 -8.521 -18.884 -1.921 1.00 1.00 C +ATOM 172 O3' A A 6 -9.506 -18.752 -0.891 1.00 1.00 O +ATOM 173 C2' A A 6 -7.148 -18.546 -1.357 1.00 1.00 C +ATOM 174 O2' A A 6 -7.255 -17.722 -0.190 1.00 1.00 O +ATOM 175 C1' A A 6 -6.545 -19.901 -1.022 1.00 1.00 C +ATOM 176 N9 A A 6 -5.103 -20.002 -1.302 1.00 1.00 N +ATOM 177 C8 A A 6 -4.456 -20.025 -2.511 1.00 1.00 C +ATOM 178 N7 A A 6 -3.160 -20.139 -2.414 1.00 1.00 N +ATOM 179 C5 A A 6 -2.933 -20.195 -1.043 1.00 1.00 C +ATOM 180 C6 A A 6 -1.759 -20.316 -0.280 1.00 1.00 C +ATOM 181 N6 A A 6 -0.543 -20.410 -0.820 1.00 1.00 N +ATOM 182 N1 A A 6 -1.893 -20.337 1.057 1.00 1.00 N +ATOM 183 C2 A A 6 -3.106 -20.245 1.588 1.00 1.00 C +ATOM 184 N3 A A 6 -4.277 -20.129 0.982 1.00 1.00 N +ATOM 185 C4 A A 6 -4.111 -20.110 -0.357 1.00 1.00 C +ATOM 186 H5' A A 6 -9.328 -20.075 -4.274 1.00 1.00 H +ATOM 187 H5'' A A 6 -7.553 -20.099 -4.294 1.00 1.00 H +ATOM 188 H4' A A 6 -9.256 -20.897 -1.911 1.00 1.00 H +ATOM 189 H3' A A 6 -8.756 -18.245 -2.773 1.00 1.00 H +ATOM 190 H2' A A 6 -6.545 -18.052 -2.122 1.00 1.00 H +ATOM 191 HO2' A A 6 -6.444 -17.833 0.312 1.00 1.00 H +ATOM 192 H1' A A 6 -6.716 -20.120 0.032 1.00 1.00 H +ATOM 193 H8 A A 6 -4.977 -19.951 -3.466 1.00 1.00 H +ATOM 194 H61 A A 6 0.267 -20.496 -0.223 1.00 1.00 H +ATOM 195 H62 A A 6 -0.428 -20.396 -1.825 1.00 1.00 H +ATOM 196 H2 A A 6 -3.143 -20.266 2.678 1.00 1.00 H +ATOM 197 P U A 7 -9.875 -17.301 -0.295 1.00 1.00 P +ATOM 198 OP1 U A 7 -11.342 -17.240 -0.107 1.00 1.00 O +ATOM 199 OP2 U A 7 -9.194 -16.276 -1.116 1.00 1.00 O +ATOM 200 O5' U A 7 -9.179 -17.328 1.160 1.00 1.00 O +ATOM 201 C5' U A 7 -9.970 -17.493 2.342 1.00 1.00 C +ATOM 202 C4' U A 7 -9.118 -17.914 3.537 1.00 1.00 C +ATOM 203 O4' U A 7 -9.074 -19.344 3.602 1.00 1.00 O +ATOM 204 C3' U A 7 -7.678 -17.401 3.481 1.00 1.00 C +ATOM 205 O3' U A 7 -7.304 -16.838 4.741 1.00 1.00 O +ATOM 206 C2' U A 7 -6.842 -18.642 3.221 1.00 1.00 C +ATOM 207 O2' U A 7 -5.599 -18.602 3.925 1.00 1.00 O +ATOM 208 C1' U A 7 -7.718 -19.777 3.726 1.00 1.00 C +ATOM 209 N1 U A 7 -7.566 -21.039 2.968 1.00 1.00 N +ATOM 210 C2 U A 7 -8.660 -21.880 2.901 1.00 1.00 C +ATOM 211 O2 U A 7 -9.728 -21.608 3.448 1.00 1.00 O +ATOM 212 N3 U A 7 -8.487 -23.049 2.182 1.00 1.00 N +ATOM 213 C4 U A 7 -7.330 -23.443 1.532 1.00 1.00 C +ATOM 214 O4 U A 7 -7.286 -24.509 0.921 1.00 1.00 O +ATOM 215 C5 U A 7 -6.236 -22.504 1.654 1.00 1.00 C +ATOM 216 C6 U A 7 -6.384 -21.352 2.354 1.00 1.00 C +ATOM 217 H5' U A 7 -10.726 -18.257 2.158 1.00 1.00 H +ATOM 218 H5'' U A 7 -10.466 -16.551 2.572 1.00 1.00 H +ATOM 219 H4' U A 7 -9.586 -17.543 4.448 1.00 1.00 H +ATOM 220 H3' U A 7 -7.553 -16.678 2.673 1.00 1.00 H +ATOM 221 H2' U A 7 -6.675 -18.751 2.147 1.00 1.00 H +ATOM 222 HO2' U A 7 -5.053 -17.936 3.502 1.00 1.00 H +ATOM 223 H1' U A 7 -7.494 -19.961 4.777 1.00 1.00 H +ATOM 224 H3 U A 7 -9.278 -23.673 2.126 1.00 1.00 H +ATOM 225 H5 U A 7 -5.282 -22.725 1.177 1.00 1.00 H +ATOM 226 H6 U A 7 -5.543 -20.662 2.429 1.00 1.00 H +ATOM 227 P G A 8 -6.111 -15.761 4.817 1.00 1.00 P +ATOM 228 OP1 G A 8 -5.605 -15.723 6.208 1.00 1.00 O +ATOM 229 OP2 G A 8 -6.570 -14.513 4.164 1.00 1.00 O +ATOM 230 O5' G A 8 -4.980 -16.428 3.884 1.00 1.00 O +ATOM 231 C5' G A 8 -3.611 -16.459 4.300 1.00 1.00 C +ATOM 232 C4' G A 8 -2.778 -15.476 3.490 1.00 1.00 C +ATOM 233 O4' G A 8 -2.193 -16.147 2.374 1.00 1.00 O +ATOM 234 C3' G A 8 -3.596 -14.321 2.942 1.00 1.00 C +ATOM 235 O3' G A 8 -3.464 -13.182 3.795 1.00 1.00 O +ATOM 236 C2' G A 8 -2.974 -14.020 1.591 1.00 1.00 C +ATOM 237 O2' G A 8 -2.074 -12.911 1.664 1.00 1.00 O +ATOM 238 C1' G A 8 -2.246 -15.302 1.217 1.00 1.00 C +ATOM 239 N9 G A 8 -2.905 -16.057 0.138 1.00 1.00 N +ATOM 240 C8 G A 8 -3.912 -16.983 0.226 1.00 1.00 C +ATOM 241 N7 G A 8 -4.273 -17.484 -0.921 1.00 1.00 N +ATOM 242 C5 G A 8 -3.447 -16.849 -1.842 1.00 1.00 C +ATOM 243 C6 G A 8 -3.383 -16.993 -3.255 1.00 1.00 C +ATOM 244 O6 G A 8 -4.059 -17.722 -3.979 1.00 1.00 O +ATOM 245 N1 G A 8 -2.411 -16.171 -3.808 1.00 1.00 N +ATOM 246 C2 G A 8 -1.600 -15.314 -3.094 1.00 1.00 C +ATOM 247 N2 G A 8 -0.722 -14.606 -3.805 1.00 1.00 N +ATOM 248 N3 G A 8 -1.658 -15.176 -1.762 1.00 1.00 N +ATOM 249 C4 G A 8 -2.603 -15.971 -1.205 1.00 1.00 C +ATOM 250 H5' G A 8 -3.216 -17.465 4.153 1.00 1.00 H +ATOM 251 H5'' G A 8 -3.549 -16.198 5.355 1.00 1.00 H +ATOM 252 H4' G A 8 -1.980 -15.082 4.118 1.00 1.00 H +ATOM 253 H3' G A 8 -4.643 -14.608 2.831 1.00 1.00 H +ATOM 254 H2' G A 8 -3.764 -13.829 0.867 1.00 1.00 H +ATOM 255 HO2' G A 8 -2.289 -12.321 0.938 1.00 1.00 H +ATOM 256 H1' G A 8 -1.233 -15.057 0.905 1.00 1.00 H +ATOM 257 H8 G A 8 -4.366 -17.277 1.172 1.00 1.00 H +ATOM 258 H1 G A 8 -2.308 -16.218 -4.811 1.00 1.00 H +ATOM 259 H21 G A 8 -0.684 -14.720 -4.815 1.00 1.00 H +ATOM 260 H22 G A 8 -0.104 -13.964 -3.351 1.00 1.00 H +ATOM 261 P G A 9 -4.312 -11.851 3.491 1.00 1.00 P +ATOM 262 OP1 G A 9 -4.172 -10.933 4.643 1.00 1.00 O +ATOM 263 OP2 G A 9 -5.658 -12.258 3.029 1.00 1.00 O +ATOM 264 O5' G A 9 -3.520 -11.217 2.242 1.00 1.00 O +ATOM 265 C5' G A 9 -4.197 -10.935 1.016 1.00 1.00 C +ATOM 266 C4' G A 9 -3.211 -10.700 -0.122 1.00 1.00 C +ATOM 267 O4' G A 9 -2.863 -11.948 -0.726 1.00 1.00 O +ATOM 268 C3' G A 9 -3.745 -9.808 -1.228 1.00 1.00 C +ATOM 269 O3' G A 9 -3.382 -8.448 -0.962 1.00 1.00 O +ATOM 270 C2' G A 9 -3.014 -10.308 -2.464 1.00 1.00 C +ATOM 271 O2' G A 9 -1.794 -9.590 -2.675 1.00 1.00 O +ATOM 272 C1' G A 9 -2.749 -11.776 -2.147 1.00 1.00 C +ATOM 273 N9 G A 9 -3.700 -12.703 -2.789 1.00 1.00 N +ATOM 274 C8 G A 9 -4.636 -13.514 -2.200 1.00 1.00 C +ATOM 275 N7 G A 9 -5.329 -14.225 -3.046 1.00 1.00 N +ATOM 276 C5 G A 9 -4.816 -13.860 -4.288 1.00 1.00 C +ATOM 277 C6 G A 9 -5.179 -14.305 -5.588 1.00 1.00 C +ATOM 278 O6 G A 9 -6.041 -15.123 -5.903 1.00 1.00 O +ATOM 279 N1 G A 9 -4.415 -13.687 -6.570 1.00 1.00 N +ATOM 280 C2 G A 9 -3.425 -12.757 -6.333 1.00 1.00 C +ATOM 281 N2 G A 9 -2.799 -12.275 -7.406 1.00 1.00 N +ATOM 282 N3 G A 9 -3.083 -12.337 -5.111 1.00 1.00 N +ATOM 283 C4 G A 9 -3.818 -12.929 -4.140 1.00 1.00 C +ATOM 284 H5' G A 9 -4.812 -10.045 1.145 1.00 1.00 H +ATOM 285 H5'' G A 9 -4.841 -11.779 0.763 1.00 1.00 H +ATOM 286 H4' G A 9 -2.307 -10.253 0.285 1.00 1.00 H +ATOM 287 H3' G A 9 -4.825 -9.923 -1.337 1.00 1.00 H +ATOM 288 H2' G A 9 -3.661 -10.233 -3.336 1.00 1.00 H +ATOM 289 HO2' G A 9 -1.072 -10.209 -2.548 1.00 1.00 H +ATOM 290 H1' G A 9 -1.738 -12.033 -2.461 1.00 1.00 H +ATOM 291 H8 G A 9 -4.786 -13.563 -1.121 1.00 1.00 H +ATOM 292 H1 G A 9 -4.616 -13.953 -7.523 1.00 1.00 H +ATOM 293 H21 G A 9 -3.058 -12.592 -8.328 1.00 1.00 H +ATOM 294 H22 G A 9 -2.064 -11.590 -7.297 1.00 1.00 H +ATOM 295 P A A 10 -4.390 -7.245 -1.319 1.00 1.00 P +ATOM 296 OP1 A A 10 -3.778 -5.977 -0.861 1.00 1.00 O +ATOM 297 OP2 A A 10 -5.744 -7.621 -0.854 1.00 1.00 O +ATOM 298 O5' A A 10 -4.392 -7.249 -2.927 1.00 1.00 O +ATOM 299 C5' A A 10 -3.205 -6.923 -3.652 1.00 1.00 C +ATOM 300 C4' A A 10 -3.349 -7.249 -5.134 1.00 1.00 C +ATOM 301 O4' A A 10 -3.483 -8.654 -5.318 1.00 1.00 O +ATOM 302 C3' A A 10 -4.559 -6.624 -5.805 1.00 1.00 C +ATOM 303 O3' A A 10 -4.233 -5.314 -6.287 1.00 1.00 O +ATOM 304 C2' A A 10 -4.824 -7.556 -6.976 1.00 1.00 C +ATOM 305 O2' A A 10 -4.216 -7.073 -8.176 1.00 1.00 O +ATOM 306 C1' A A 10 -4.211 -8.883 -6.531 1.00 1.00 C +ATOM 307 N9 A A 10 -5.204 -9.943 -6.285 1.00 1.00 N +ATOM 308 C8 A A 10 -5.869 -10.265 -5.129 1.00 1.00 C +ATOM 309 N7 A A 10 -6.683 -11.277 -5.252 1.00 1.00 N +ATOM 310 C5 A A 10 -6.548 -11.652 -6.587 1.00 1.00 C +ATOM 311 C6 A A 10 -7.147 -12.666 -7.353 1.00 1.00 C +ATOM 312 N6 A A 10 -8.039 -13.524 -6.857 1.00 1.00 N +ATOM 313 N1 A A 10 -6.787 -12.757 -8.643 1.00 1.00 N +ATOM 314 C2 A A 10 -5.898 -11.900 -9.131 1.00 1.00 C +ATOM 315 N3 A A 10 -5.268 -10.910 -8.516 1.00 1.00 N +ATOM 316 C4 A A 10 -5.649 -10.844 -7.223 1.00 1.00 C +ATOM 317 H5' A A 10 -2.370 -7.492 -3.241 1.00 1.00 H +ATOM 318 H5'' A A 10 -3.000 -5.859 -3.541 1.00 1.00 H +ATOM 319 H4' A A 10 -2.450 -6.923 -5.653 1.00 1.00 H +ATOM 320 H3' A A 10 -5.413 -6.599 -5.124 1.00 1.00 H +ATOM 321 H2' A A 10 -5.900 -7.677 -7.111 1.00 1.00 H +ATOM 322 HO2' A A 10 -4.074 -6.130 -8.064 1.00 1.00 H +ATOM 323 H1' A A 10 -3.518 -9.225 -7.299 1.00 1.00 H +ATOM 324 H8 A A 10 -5.730 -9.724 -4.192 1.00 1.00 H +ATOM 325 H61 A A 10 -8.443 -14.238 -7.454 1.00 1.00 H +ATOM 326 H62 A A 10 -8.315 -13.462 -5.888 1.00 1.00 H +ATOM 327 H2 A A 10 -5.651 -12.030 -10.185 1.00 1.00 H +ATOM 328 P A A 11 -5.390 -4.225 -6.554 1.00 1.00 P +ATOM 329 OP1 A A 11 -4.772 -2.881 -6.530 1.00 1.00 O +ATOM 330 OP2 A A 11 -6.529 -4.530 -5.658 1.00 1.00 O +ATOM 331 O5' A A 11 -5.841 -4.540 -8.069 1.00 1.00 O +ATOM 332 C5' A A 11 -5.044 -4.094 -9.171 1.00 1.00 C +ATOM 333 C4' A A 11 -5.523 -4.685 -10.495 1.00 1.00 C +ATOM 334 O4' A A 11 -5.596 -6.109 -10.388 1.00 1.00 O +ATOM 335 C3' A A 11 -6.901 -4.204 -10.932 1.00 1.00 C +ATOM 336 O3' A A 11 -6.765 -3.054 -11.778 1.00 1.00 O +ATOM 337 C2' A A 11 -7.426 -5.382 -11.735 1.00 1.00 C +ATOM 338 O2' A A 11 -7.027 -5.304 -13.107 1.00 1.00 O +ATOM 339 C1' A A 11 -6.790 -6.573 -11.034 1.00 1.00 C +ATOM 340 N9 A A 11 -7.653 -7.176 -10.005 1.00 1.00 N +ATOM 341 C8 A A 11 -7.746 -6.878 -8.670 1.00 1.00 C +ATOM 342 N7 A A 11 -8.610 -7.612 -8.024 1.00 1.00 N +ATOM 343 C5 A A 11 -9.127 -8.455 -9.004 1.00 1.00 C +ATOM 344 C6 A A 11 -10.092 -9.476 -8.965 1.00 1.00 C +ATOM 345 N6 A A 11 -10.734 -9.832 -7.851 1.00 1.00 N +ATOM 346 N1 A A 11 -10.366 -10.109 -10.119 1.00 1.00 N +ATOM 347 C2 A A 11 -9.724 -9.750 -11.223 1.00 1.00 C +ATOM 348 N3 A A 11 -8.801 -8.814 -11.387 1.00 1.00 N +ATOM 349 C4 A A 11 -8.548 -8.196 -10.213 1.00 1.00 C +ATOM 350 H5' A A 11 -4.008 -4.393 -9.002 1.00 1.00 H +ATOM 351 H5'' A A 11 -5.095 -3.008 -9.228 1.00 1.00 H +ATOM 352 H4' A A 11 -4.801 -4.435 -11.270 1.00 1.00 H +ATOM 353 H3' A A 11 -7.538 -3.999 -10.071 1.00 1.00 H +ATOM 354 H2' A A 11 -8.509 -5.445 -11.650 1.00 1.00 H +ATOM 355 HO2' A A 11 -7.772 -4.954 -13.600 1.00 1.00 H +ATOM 356 H1' A A 11 -6.530 -7.333 -11.773 1.00 1.00 H +ATOM 357 H8 A A 11 -7.152 -6.098 -8.191 1.00 1.00 H +ATOM 358 H61 A A 11 -11.421 -10.573 -7.879 1.00 1.00 H +ATOM 359 H62 A A 11 -10.535 -9.360 -6.983 1.00 1.00 H +ATOM 360 H2 A A 11 -9.994 -10.304 -12.123 1.00 1.00 H +ATOM 361 P G A 12 -7.635 -1.722 -11.510 1.00 1.00 P +ATOM 362 OP1 G A 12 -7.026 -0.613 -12.279 1.00 1.00 O +ATOM 363 OP2 G A 12 -7.825 -1.586 -10.048 1.00 1.00 O +ATOM 364 O5' G A 12 -9.064 -2.067 -12.171 1.00 1.00 O +ATOM 365 C5' G A 12 -9.262 -1.930 -13.581 1.00 1.00 C +ATOM 366 C4' G A 12 -10.582 -2.550 -14.031 1.00 1.00 C +ATOM 367 O4' G A 12 -10.584 -3.944 -13.732 1.00 1.00 O +ATOM 368 C3' G A 12 -11.825 -1.970 -13.368 1.00 1.00 C +ATOM 369 O3' G A 12 -12.303 -0.849 -14.125 1.00 1.00 O +ATOM 370 C2' G A 12 -12.814 -3.120 -13.453 1.00 1.00 C +ATOM 371 O2' G A 12 -13.561 -3.079 -14.674 1.00 1.00 O +ATOM 372 C1' G A 12 -11.918 -4.348 -13.386 1.00 1.00 C +ATOM 373 N9 G A 12 -11.871 -4.971 -12.052 1.00 1.00 N +ATOM 374 C8 G A 12 -10.966 -4.786 -11.039 1.00 1.00 C +ATOM 375 N7 G A 12 -11.185 -5.533 -9.993 1.00 1.00 N +ATOM 376 C5 G A 12 -12.318 -6.267 -10.335 1.00 1.00 C +ATOM 377 C6 G A 12 -13.027 -7.248 -9.589 1.00 1.00 C +ATOM 378 O6 G A 12 -12.787 -7.670 -8.460 1.00 1.00 O +ATOM 379 N1 G A 12 -14.114 -7.741 -10.300 1.00 1.00 N +ATOM 380 C2 G A 12 -14.474 -7.342 -11.570 1.00 1.00 C +ATOM 381 N2 G A 12 -15.552 -7.928 -12.089 1.00 1.00 N +ATOM 382 N3 G A 12 -13.808 -6.421 -12.272 1.00 1.00 N +ATOM 383 C4 G A 12 -12.745 -5.928 -11.594 1.00 1.00 C +ATOM 384 H5' G A 12 -8.442 -2.423 -14.104 1.00 1.00 H +ATOM 385 H5'' G A 12 -9.261 -0.871 -13.839 1.00 1.00 H +ATOM 386 H4' G A 12 -10.674 -2.434 -15.109 1.00 1.00 H +ATOM 387 H3' G A 12 -11.625 -1.700 -12.329 1.00 1.00 H +ATOM 388 H2' G A 12 -13.481 -3.109 -12.591 1.00 1.00 H +ATOM 389 HO2' G A 12 -13.296 -2.284 -15.143 1.00 1.00 H +ATOM 390 H1' G A 12 -12.265 -5.086 -14.107 1.00 1.00 H +ATOM 391 H8 G A 12 -10.140 -4.079 -11.102 1.00 1.00 H +ATOM 392 H1 G A 12 -14.667 -8.445 -9.835 1.00 1.00 H +ATOM 393 H21 G A 12 -16.044 -8.611 -11.565 1.00 1.00 H +ATOM 394 H22 G A 12 -15.867 -7.678 -13.015 1.00 1.00 H +ATOM 395 P A A 13 -13.198 0.299 -13.430 1.00 1.00 P +ATOM 396 OP1 A A 13 -13.453 1.358 -14.433 1.00 1.00 O +ATOM 397 OP2 A A 13 -12.576 0.648 -12.134 1.00 1.00 O +ATOM 398 O5' A A 13 -14.592 -0.455 -13.133 1.00 1.00 O +ATOM 399 C5' A A 13 -15.546 -0.655 -14.179 1.00 1.00 C +ATOM 400 C4' A A 13 -16.785 -1.394 -13.682 1.00 1.00 C +ATOM 401 O4' A A 13 -16.431 -2.713 -13.277 1.00 1.00 O +ATOM 402 C3' A A 13 -17.472 -0.754 -12.487 1.00 1.00 C +ATOM 403 O3' A A 13 -18.424 0.219 -12.938 1.00 1.00 O +ATOM 404 C2' A A 13 -18.186 -1.934 -11.848 1.00 1.00 C +ATOM 405 O2' A A 13 -19.496 -2.116 -12.396 1.00 1.00 O +ATOM 406 C1' A A 13 -17.271 -3.111 -12.184 1.00 1.00 C +ATOM 407 N9 A A 13 -16.399 -3.526 -11.074 1.00 1.00 N +ATOM 408 C8 A A 13 -15.218 -2.981 -10.641 1.00 1.00 C +ATOM 409 N7 A A 13 -14.684 -3.615 -9.633 1.00 1.00 N +ATOM 410 C5 A A 13 -15.577 -4.653 -9.381 1.00 1.00 C +ATOM 411 C6 A A 13 -15.585 -5.689 -8.432 1.00 1.00 C +ATOM 412 N6 A A 13 -14.626 -5.852 -7.519 1.00 1.00 N +ATOM 413 N1 A A 13 -16.621 -6.544 -8.463 1.00 1.00 N +ATOM 414 C2 A A 13 -17.573 -6.377 -9.374 1.00 1.00 C +ATOM 415 N3 A A 13 -17.677 -5.448 -10.312 1.00 1.00 N +ATOM 416 C4 A A 13 -16.624 -4.606 -10.255 1.00 1.00 C +ATOM 417 H5' A A 13 -15.083 -1.239 -14.976 1.00 1.00 H +ATOM 418 H5'' A A 13 -15.846 0.313 -14.577 1.00 1.00 H +ATOM 419 H4' A A 13 -17.500 -1.468 -14.499 1.00 1.00 H +ATOM 420 H3' A A 13 -16.742 -0.318 -11.803 1.00 1.00 H +ATOM 421 H2' A A 13 -18.235 -1.802 -10.768 1.00 1.00 H +ATOM 422 HO2' A A 13 -19.909 -2.835 -11.913 1.00 1.00 H +ATOM 423 H1' A A 13 -17.879 -3.963 -12.490 1.00 1.00 H +ATOM 424 H8 A A 13 -14.767 -2.099 -11.095 1.00 1.00 H +ATOM 425 H61 A A 13 -14.683 -6.613 -6.861 1.00 1.00 H +ATOM 426 H62 A A 13 -13.845 -5.214 -7.487 1.00 1.00 H +ATOM 427 H2 A A 13 -18.384 -7.105 -9.342 1.00 1.00 H +ATOM 428 P A A 14 -18.664 1.587 -12.117 1.00 1.00 P +ATOM 429 OP1 A A 14 -19.580 2.442 -12.906 1.00 1.00 O +ATOM 430 OP2 A A 14 -17.346 2.111 -11.699 1.00 1.00 O +ATOM 431 O5' A A 14 -19.450 1.093 -10.800 1.00 1.00 O +ATOM 432 C5' A A 14 -20.859 0.850 -10.845 1.00 1.00 C +ATOM 433 C4' A A 14 -21.364 0.211 -9.553 1.00 1.00 C +ATOM 434 O4' A A 14 -20.741 -1.055 -9.361 1.00 1.00 O +ATOM 435 C3' A A 14 -21.079 1.014 -8.294 1.00 1.00 C +ATOM 436 O3' A A 14 -22.152 1.931 -8.043 1.00 1.00 O +ATOM 437 C2' A A 14 -21.033 -0.045 -7.205 1.00 1.00 C +ATOM 438 O2' A A 14 -22.300 -0.180 -6.553 1.00 1.00 O +ATOM 439 C1' A A 14 -20.651 -1.321 -7.952 1.00 1.00 C +ATOM 440 N9 A A 14 -19.279 -1.777 -7.669 1.00 1.00 N +ATOM 441 C8 A A 14 -18.097 -1.336 -8.205 1.00 1.00 C +ATOM 442 N7 A A 14 -17.045 -1.960 -7.750 1.00 1.00 N +ATOM 443 C5 A A 14 -17.569 -2.882 -6.850 1.00 1.00 C +ATOM 444 C6 A A 14 -16.970 -3.852 -6.028 1.00 1.00 C +ATOM 445 N6 A A 14 -15.654 -4.061 -5.985 1.00 1.00 N +ATOM 446 N1 A A 14 -17.784 -4.595 -5.259 1.00 1.00 N +ATOM 447 C2 A A 14 -19.093 -4.383 -5.306 1.00 1.00 C +ATOM 448 N3 A A 14 -19.772 -3.507 -6.032 1.00 1.00 N +ATOM 449 C4 A A 14 -18.929 -2.777 -6.793 1.00 1.00 C +ATOM 450 H5' A A 14 -21.078 0.183 -11.680 1.00 1.00 H +ATOM 451 H5'' A A 14 -21.377 1.796 -11.000 1.00 1.00 H +ATOM 452 H4' A A 14 -22.438 0.054 -9.634 1.00 1.00 H +ATOM 453 H3' A A 14 -20.122 1.533 -8.373 1.00 1.00 H +ATOM 454 H2' A A 14 -20.254 0.202 -6.487 1.00 1.00 H +ATOM 455 HO2' A A 14 -22.170 0.043 -5.628 1.00 1.00 H +ATOM 456 H1' A A 14 -21.349 -2.116 -7.692 1.00 1.00 H +ATOM 457 H8 A A 14 -18.041 -0.533 -8.941 1.00 1.00 H +ATOM 458 H61 A A 14 -15.279 -4.770 -5.379 1.00 1.00 H +ATOM 459 H62 A A 14 -15.035 -3.507 -6.560 1.00 1.00 H +ATOM 460 H2 A A 14 -19.694 -5.018 -4.656 1.00 1.00 H +ATOM 461 P C A 15 -21.943 3.179 -7.044 1.00 1.00 P +ATOM 462 OP1 C A 15 -23.137 4.049 -7.134 1.00 1.00 O +ATOM 463 OP2 C A 15 -20.599 3.746 -7.291 1.00 1.00 O +ATOM 464 O5' C A 15 -21.934 2.483 -5.588 1.00 1.00 O +ATOM 465 C5' C A 15 -23.161 2.109 -4.951 1.00 1.00 C +ATOM 466 C4' C A 15 -22.921 1.531 -3.556 1.00 1.00 C +ATOM 467 O4' C A 15 -22.207 0.300 -3.648 1.00 1.00 O +ATOM 468 C3' C A 15 -22.107 2.422 -2.639 1.00 1.00 C +ATOM 469 O3' C A 15 -22.972 3.323 -1.942 1.00 1.00 O +ATOM 470 C2' C A 15 -21.477 1.437 -1.666 1.00 1.00 C +ATOM 471 O2' C A 15 -22.299 1.246 -0.509 1.00 1.00 O +ATOM 472 C1' C A 15 -21.364 0.152 -2.489 1.00 1.00 C +ATOM 473 N1 C A 15 -19.997 -0.122 -2.976 1.00 1.00 N +ATOM 474 C2 C A 15 -19.243 -1.078 -2.313 1.00 1.00 C +ATOM 475 O2 C A 15 -19.716 -1.675 -1.348 1.00 1.00 O +ATOM 476 N3 C A 15 -17.981 -1.331 -2.761 1.00 1.00 N +ATOM 477 C4 C A 15 -17.481 -0.671 -3.816 1.00 1.00 C +ATOM 478 N4 C A 15 -16.243 -0.941 -4.228 1.00 1.00 N +ATOM 479 C5 C A 15 -18.256 0.315 -4.502 1.00 1.00 C +ATOM 480 C6 C A 15 -19.503 0.557 -4.052 1.00 1.00 C +ATOM 481 H5' C A 15 -23.666 1.363 -5.564 1.00 1.00 H +ATOM 482 H5'' C A 15 -23.798 2.989 -4.865 1.00 1.00 H +ATOM 483 H4' C A 15 -23.883 1.333 -3.090 1.00 1.00 H +ATOM 484 H3' C A 15 -21.340 2.959 -3.201 1.00 1.00 H +ATOM 485 H2' C A 15 -20.481 1.784 -1.380 1.00 1.00 H +ATOM 486 HO2' C A 15 -21.943 0.495 -0.028 1.00 1.00 H +ATOM 487 H1' C A 15 -21.713 -0.688 -1.894 1.00 1.00 H +ATOM 488 H41 C A 15 -15.689 -1.636 -3.747 1.00 1.00 H +ATOM 489 H42 C A 15 -15.856 -0.449 -5.022 1.00 1.00 H +ATOM 490 H5 C A 15 -17.854 0.852 -5.361 1.00 1.00 H +ATOM 491 H6 C A 15 -20.122 1.302 -4.551 1.00 1.00 H +ATOM 492 P C A 16 -22.398 4.699 -1.337 1.00 1.00 P +ATOM 493 OP1 C A 16 -23.496 5.378 -0.613 1.00 1.00 O +ATOM 494 OP2 C A 16 -21.669 5.409 -2.410 1.00 1.00 O +ATOM 495 O5' C A 16 -21.327 4.176 -0.253 1.00 1.00 O +ATOM 496 C5' C A 16 -21.764 3.439 0.891 1.00 1.00 C +ATOM 497 C4' C A 16 -20.633 2.621 1.506 1.00 1.00 C +ATOM 498 O4' C A 16 -20.025 1.803 0.513 1.00 1.00 O +ATOM 499 C3' C A 16 -19.515 3.446 2.119 1.00 1.00 C +ATOM 500 O3' C A 16 -19.805 3.699 3.498 1.00 1.00 O +ATOM 501 C2' C A 16 -18.302 2.535 2.013 1.00 1.00 C +ATOM 502 O2' C A 16 -18.066 1.837 3.242 1.00 1.00 O +ATOM 503 C1' C A 16 -18.659 1.569 0.883 1.00 1.00 C +ATOM 504 N1 C A 16 -17.816 1.718 -0.328 1.00 1.00 N +ATOM 505 C2 C A 16 -16.776 0.818 -0.495 1.00 1.00 C +ATOM 506 O2 C A 16 -16.574 -0.052 0.349 1.00 1.00 O +ATOM 507 N3 C A 16 -15.998 0.930 -1.606 1.00 1.00 N +ATOM 508 C4 C A 16 -16.230 1.886 -2.515 1.00 1.00 C +ATOM 509 N4 C A 16 -15.449 1.965 -3.593 1.00 1.00 N +ATOM 510 C5 C A 16 -17.301 2.819 -2.346 1.00 1.00 C +ATOM 511 C6 C A 16 -18.066 2.700 -1.243 1.00 1.00 C +ATOM 512 H5' C A 16 -22.569 2.766 0.592 1.00 1.00 H +ATOM 513 H5'' C A 16 -22.144 4.136 1.637 1.00 1.00 H +ATOM 514 H4' C A 16 -21.049 1.971 2.273 1.00 1.00 H +ATOM 515 H3' C A 16 -19.361 4.373 1.563 1.00 1.00 H +ATOM 516 H2' C A 16 -17.428 3.125 1.730 1.00 1.00 H +ATOM 517 HO2' C A 16 -18.666 1.087 3.264 1.00 1.00 H +ATOM 518 H1' C A 16 -18.572 0.547 1.254 1.00 1.00 H +ATOM 519 H41 C A 16 -14.694 1.310 -3.715 1.00 1.00 H +ATOM 520 H42 C A 16 -15.614 2.682 -4.285 1.00 1.00 H +ATOM 521 H5 C A 16 -17.491 3.599 -3.084 1.00 1.00 H +ATOM 522 H6 C A 16 -18.889 3.395 -1.078 1.00 1.00 H +ATOM 523 P G A 17 -18.907 4.731 4.348 1.00 1.00 P +ATOM 524 OP1 G A 17 -19.676 5.131 5.548 1.00 1.00 O +ATOM 525 OP2 G A 17 -18.391 5.765 3.425 1.00 1.00 O +ATOM 526 O5' G A 17 -17.665 3.821 4.828 1.00 1.00 O +ATOM 527 C5' G A 17 -17.802 2.922 5.935 1.00 1.00 C +ATOM 528 C4' G A 17 -16.446 2.388 6.400 1.00 1.00 C +ATOM 529 O4' G A 17 -15.894 1.517 5.416 1.00 1.00 O +ATOM 530 C3' G A 17 -15.401 3.463 6.656 1.00 1.00 C +ATOM 531 O3' G A 17 -15.462 3.897 8.018 1.00 1.00 O +ATOM 532 C2' G A 17 -14.082 2.754 6.397 1.00 1.00 C +ATOM 533 O2' G A 17 -13.500 2.272 7.612 1.00 1.00 O +ATOM 534 C1' G A 17 -14.460 1.603 5.466 1.00 1.00 C +ATOM 535 N9 G A 17 -13.977 1.778 4.089 1.00 1.00 N +ATOM 536 C8 G A 17 -14.683 2.157 2.976 1.00 1.00 C +ATOM 537 N7 G A 17 -13.962 2.230 1.892 1.00 1.00 N +ATOM 538 C5 G A 17 -12.684 1.874 2.313 1.00 1.00 C +ATOM 539 C6 G A 17 -11.476 1.774 1.570 1.00 1.00 C +ATOM 540 O6 G A 17 -11.295 1.987 0.373 1.00 1.00 O +ATOM 541 N1 G A 17 -10.414 1.385 2.376 1.00 1.00 N +ATOM 542 C2 G A 17 -10.500 1.124 3.726 1.00 1.00 C +ATOM 543 N2 G A 17 -9.366 0.764 4.328 1.00 1.00 N +ATOM 544 N3 G A 17 -11.635 1.215 4.428 1.00 1.00 N +ATOM 545 C4 G A 17 -12.683 1.594 3.657 1.00 1.00 C +ATOM 546 H5' G A 17 -18.431 2.082 5.635 1.00 1.00 H +ATOM 547 H5'' G A 17 -18.279 3.448 6.761 1.00 1.00 H +ATOM 548 H4' G A 17 -16.592 1.817 7.315 1.00 1.00 H +ATOM 549 H3' G A 17 -15.533 4.300 5.966 1.00 1.00 H +ATOM 550 H2' G A 17 -13.395 3.431 5.885 1.00 1.00 H +ATOM 551 HO2' G A 17 -12.797 1.667 7.369 1.00 1.00 H +ATOM 552 H1' G A 17 -14.058 0.675 5.867 1.00 1.00 H +ATOM 553 H8 G A 17 -15.750 2.377 2.995 1.00 1.00 H +ATOM 554 H1 G A 17 -9.520 1.294 1.916 1.00 1.00 H +ATOM 555 H21 G A 17 -8.510 0.697 3.796 1.00 1.00 H +ATOM 556 H22 G A 17 -9.363 0.560 5.317 1.00 1.00 H +ATOM 557 P G A 18 -14.822 5.312 8.449 1.00 1.00 P +ATOM 558 OP1 G A 18 -15.143 5.549 9.875 1.00 1.00 O +ATOM 559 OP2 G A 18 -15.197 6.317 7.430 1.00 1.00 O +ATOM 560 O5' G A 18 -13.237 5.037 8.327 1.00 1.00 O +ATOM 561 C5' G A 18 -12.595 4.105 9.203 1.00 1.00 C +ATOM 562 C4' G A 18 -11.115 3.923 8.864 1.00 1.00 C +ATOM 563 O4' G A 18 -10.974 3.484 7.517 1.00 1.00 O +ATOM 564 C3' G A 18 -10.270 5.181 8.994 1.00 1.00 C +ATOM 565 O3' G A 18 -9.725 5.266 10.317 1.00 1.00 O +ATOM 566 C2' G A 18 -9.147 4.963 7.993 1.00 1.00 C +ATOM 567 O2' G A 18 -7.966 4.466 8.631 1.00 1.00 O +ATOM 568 C1' G A 18 -9.716 3.947 7.007 1.00 1.00 C +ATOM 569 N9 G A 18 -9.935 4.497 5.659 1.00 1.00 N +ATOM 570 C8 G A 18 -11.064 5.069 5.132 1.00 1.00 C +ATOM 571 N7 G A 18 -10.933 5.453 3.894 1.00 1.00 N +ATOM 572 C5 G A 18 -9.624 5.112 3.573 1.00 1.00 C +ATOM 573 C6 G A 18 -8.909 5.286 2.355 1.00 1.00 C +ATOM 574 O6 G A 18 -9.302 5.788 1.303 1.00 1.00 O +ATOM 575 N1 G A 18 -7.610 4.804 2.452 1.00 1.00 N +ATOM 576 C2 G A 18 -7.064 4.226 3.578 1.00 1.00 C +ATOM 577 N2 G A 18 -5.798 3.822 3.479 1.00 1.00 N +ATOM 578 N3 G A 18 -7.734 4.060 4.724 1.00 1.00 N +ATOM 579 C4 G A 18 -9.003 4.525 4.648 1.00 1.00 C +ATOM 580 H5' G A 18 -13.098 3.141 9.124 1.00 1.00 H +ATOM 581 H5'' G A 18 -12.681 4.465 10.227 1.00 1.00 H +ATOM 582 H4' G A 18 -10.702 3.157 9.516 1.00 1.00 H +ATOM 583 H3' G A 18 -10.851 6.071 8.742 1.00 1.00 H +ATOM 584 H2' G A 18 -8.937 5.894 7.470 1.00 1.00 H +ATOM 585 HO2' G A 18 -7.442 4.025 7.957 1.00 1.00 H +ATOM 586 H1' G A 18 -9.032 3.104 6.934 1.00 1.00 H +ATOM 587 H8 G A 18 -11.989 5.191 5.697 1.00 1.00 H +ATOM 588 H1 G A 18 -7.039 4.894 1.624 1.00 1.00 H +ATOM 589 H21 G A 18 -5.295 3.949 2.612 1.00 1.00 H +ATOM 590 H22 G A 18 -5.341 3.391 4.270 1.00 1.00 H +ATOM 591 P G A 19 -9.073 6.641 10.852 1.00 1.00 P +ATOM 592 OP1 G A 19 -8.794 6.487 12.298 1.00 1.00 O +ATOM 593 OP2 G A 19 -9.912 7.763 10.379 1.00 1.00 O +ATOM 594 O5' G A 19 -7.661 6.704 10.071 1.00 1.00 O +ATOM 595 C5' G A 19 -6.610 5.777 10.374 1.00 1.00 C +ATOM 596 C4' G A 19 -5.335 6.093 9.590 1.00 1.00 C +ATOM 597 O4' G A 19 -5.536 5.841 8.201 1.00 1.00 O +ATOM 598 C3' G A 19 -4.878 7.536 9.708 1.00 1.00 C +ATOM 599 O3' G A 19 -3.983 7.671 10.817 1.00 1.00 O +ATOM 600 C2' G A 19 -4.138 7.781 8.400 1.00 1.00 C +ATOM 601 O2' G A 19 -2.738 7.516 8.534 1.00 1.00 O +ATOM 602 C1' G A 19 -4.801 6.803 7.428 1.00 1.00 C +ATOM 603 N9 G A 19 -5.751 7.434 6.504 1.00 1.00 N +ATOM 604 C8 G A 19 -7.060 7.775 6.722 1.00 1.00 C +ATOM 605 N7 G A 19 -7.647 8.310 5.688 1.00 1.00 N +ATOM 606 C5 G A 19 -6.657 8.327 4.711 1.00 1.00 C +ATOM 607 C6 G A 19 -6.708 8.797 3.369 1.00 1.00 C +ATOM 608 O6 G A 19 -7.658 9.299 2.772 1.00 1.00 O +ATOM 609 N1 G A 19 -5.490 8.630 2.723 1.00 1.00 N +ATOM 610 C2 G A 19 -4.362 8.080 3.294 1.00 1.00 C +ATOM 611 N2 G A 19 -3.284 8.004 2.514 1.00 1.00 N +ATOM 612 N3 G A 19 -4.311 7.638 4.555 1.00 1.00 N +ATOM 613 C4 G A 19 -5.491 7.792 5.201 1.00 1.00 C +ATOM 614 H5' G A 19 -6.941 4.770 10.123 1.00 1.00 H +ATOM 615 H5'' G A 19 -6.392 5.824 11.441 1.00 1.00 H +ATOM 616 H4' G A 19 -4.537 5.443 9.943 1.00 1.00 H +ATOM 617 H3' G A 19 -5.734 8.205 9.803 1.00 1.00 H +ATOM 618 H2' G A 19 -4.306 8.808 8.064 1.00 1.00 H +ATOM 619 HO2' G A 19 -2.600 7.144 9.408 1.00 1.00 H +ATOM 620 H1' G A 19 -4.033 6.292 6.846 1.00 1.00 H +ATOM 621 H8 G A 19 -7.567 7.613 7.674 1.00 1.00 H +ATOM 622 H1 G A 19 -5.450 8.942 1.764 1.00 1.00 H +ATOM 623 H21 G A 19 -3.325 8.340 1.560 1.00 1.00 H +ATOM 624 H22 G A 19 -2.427 7.612 2.874 1.00 1.00 H +ATOM 625 P G A 20 -4.081 8.945 11.800 1.00 1.00 P +ATOM 626 OP1 G A 20 -2.905 8.928 12.698 1.00 1.00 O +ATOM 627 OP2 G A 20 -5.445 8.985 12.373 1.00 1.00 O +ATOM 628 O5' G A 20 -3.923 10.185 10.788 1.00 1.00 O +ATOM 629 C5' G A 20 -2.630 10.615 10.358 1.00 1.00 C +ATOM 630 C4' G A 20 -2.730 11.693 9.283 1.00 1.00 C +ATOM 631 O4' G A 20 -3.292 11.141 8.093 1.00 1.00 O +ATOM 632 C3' G A 20 -3.602 12.873 9.677 1.00 1.00 C +ATOM 633 O3' G A 20 -2.791 13.891 10.271 1.00 1.00 O +ATOM 634 C2' G A 20 -4.159 13.365 8.352 1.00 1.00 C +ATOM 635 O2' G A 20 -3.346 14.410 7.816 1.00 1.00 O +ATOM 636 C1' G A 20 -4.138 12.118 7.465 1.00 1.00 C +ATOM 637 N9 G A 20 -5.461 11.498 7.285 1.00 1.00 N +ATOM 638 C8 G A 20 -6.135 10.672 8.145 1.00 1.00 C +ATOM 639 N7 G A 20 -7.294 10.277 7.701 1.00 1.00 N +ATOM 640 C5 G A 20 -7.401 10.885 6.454 1.00 1.00 C +ATOM 641 C6 G A 20 -8.453 10.823 5.500 1.00 1.00 C +ATOM 642 O6 G A 20 -9.515 10.209 5.575 1.00 1.00 O +ATOM 643 N1 G A 20 -8.165 11.580 4.374 1.00 1.00 N +ATOM 644 C2 G A 20 -7.011 12.308 4.184 1.00 1.00 C +ATOM 645 N2 G A 20 -6.919 12.970 3.031 1.00 1.00 N +ATOM 646 N3 G A 20 -6.018 12.370 5.081 1.00 1.00 N +ATOM 647 C4 G A 20 -6.282 11.636 6.189 1.00 1.00 C +ATOM 648 H5' G A 20 -2.085 9.760 9.956 1.00 1.00 H +ATOM 649 H5'' G A 20 -2.086 11.015 11.214 1.00 1.00 H +ATOM 650 H4' G A 20 -1.729 12.056 9.055 1.00 1.00 H +ATOM 651 H3' G A 20 -4.404 12.559 10.347 1.00 1.00 H +ATOM 652 H2' G A 20 -5.187 13.706 8.488 1.00 1.00 H +ATOM 653 HO2' G A 20 -3.827 15.232 7.933 1.00 1.00 H +ATOM 654 H1' G A 20 -3.729 12.370 6.485 1.00 1.00 H +ATOM 655 H8 G A 20 -5.735 10.368 9.113 1.00 1.00 H +ATOM 656 H1 G A 20 -8.869 11.584 3.649 1.00 1.00 H +ATOM 657 H21 G A 20 -7.670 12.921 2.357 1.00 1.00 H +ATOM 658 H22 G A 20 -6.102 13.521 2.833 1.00 1.00 H +ATOM 659 P A A 21 -3.443 14.997 11.241 1.00 1.00 P +ATOM 660 OP1 A A 21 -2.369 15.913 11.688 1.00 1.00 O +ATOM 661 OP2 A A 21 -4.281 14.300 12.242 1.00 1.00 O +ATOM 662 O5' A A 21 -4.415 15.810 10.247 1.00 1.00 O +ATOM 663 C5' A A 21 -5.657 16.339 10.717 1.00 1.00 C +ATOM 664 C4' A A 21 -6.210 17.400 9.769 1.00 1.00 C +ATOM 665 O4' A A 21 -5.339 18.538 9.766 1.00 1.00 O +ATOM 666 C3' A A 21 -6.354 16.921 8.327 1.00 1.00 C +ATOM 667 O3' A A 21 -7.732 16.642 8.054 1.00 1.00 O +ATOM 668 C2' A A 21 -5.893 18.105 7.490 1.00 1.00 C +ATOM 669 O2' A A 21 -6.997 18.925 7.093 1.00 1.00 O +ATOM 670 C1' A A 21 -4.954 18.853 8.424 1.00 1.00 C +ATOM 671 N9 A A 21 -3.533 18.486 8.271 1.00 1.00 N +ATOM 672 C8 A A 21 -2.745 17.747 9.114 1.00 1.00 C +ATOM 673 N7 A A 21 -1.517 17.602 8.697 1.00 1.00 N +ATOM 674 C5 A A 21 -1.491 18.299 7.492 1.00 1.00 C +ATOM 675 C6 A A 21 -0.475 18.529 6.549 1.00 1.00 C +ATOM 676 N6 A A 21 0.765 18.058 6.681 1.00 1.00 N +ATOM 677 N1 A A 21 -0.793 19.261 5.468 1.00 1.00 N +ATOM 678 C2 A A 21 -2.029 19.726 5.341 1.00 1.00 C +ATOM 679 N3 A A 21 -3.065 19.578 6.152 1.00 1.00 N +ATOM 680 C4 A A 21 -2.716 18.840 7.226 1.00 1.00 C +ATOM 681 H5' A A 21 -5.506 16.784 11.700 1.00 1.00 H +ATOM 682 H5'' A A 21 -6.380 15.526 10.801 1.00 1.00 H +ATOM 683 H4' A A 21 -7.186 17.716 10.131 1.00 1.00 H +ATOM 684 H3' A A 21 -5.728 16.047 8.143 1.00 1.00 H +ATOM 685 H2' A A 21 -5.341 17.751 6.616 1.00 1.00 H +ATOM 686 HO2' A A 21 -7.260 19.440 7.860 1.00 1.00 H +ATOM 687 H1' A A 21 -5.065 19.925 8.261 1.00 1.00 H +ATOM 688 H8 A A 21 -3.112 17.317 10.046 1.00 1.00 H +ATOM 689 H61 A A 21 1.458 18.253 5.973 1.00 1.00 H +ATOM 690 H62 A A 21 1.012 17.506 7.490 1.00 1.00 H +ATOM 691 H2 A A 21 -2.219 20.312 4.442 1.00 1.00 H +ATOM 692 P A A 22 -8.144 15.576 6.918 1.00 1.00 P +ATOM 693 OP1 A A 22 -9.381 14.890 7.355 1.00 1.00 O +ATOM 694 OP2 A A 22 -6.944 14.783 6.572 1.00 1.00 O +ATOM 695 O5' A A 22 -8.505 16.518 5.663 1.00 1.00 O +ATOM 696 C5' A A 22 -8.030 16.196 4.353 1.00 1.00 C +ATOM 697 C4' A A 22 -7.240 17.355 3.750 1.00 1.00 C +ATOM 698 O4' A A 22 -6.202 17.739 4.657 1.00 1.00 O +ATOM 699 C3' A A 22 -6.584 17.028 2.411 1.00 1.00 C +ATOM 700 O3' A A 22 -7.383 17.548 1.339 1.00 1.00 O +ATOM 701 C2' A A 22 -5.261 17.775 2.470 1.00 1.00 C +ATOM 702 O2' A A 22 -5.382 19.096 1.935 1.00 1.00 O +ATOM 703 C1' A A 22 -4.956 17.810 3.960 1.00 1.00 C +ATOM 704 N9 A A 22 -4.123 16.692 4.423 1.00 1.00 N +ATOM 705 C8 A A 22 -4.433 15.703 5.323 1.00 1.00 C +ATOM 706 N7 A A 22 -3.455 14.870 5.548 1.00 1.00 N +ATOM 707 C5 A A 22 -2.424 15.339 4.741 1.00 1.00 C +ATOM 708 C6 A A 22 -1.111 14.892 4.523 1.00 1.00 C +ATOM 709 N6 A A 22 -0.594 13.822 5.129 1.00 1.00 N +ATOM 710 N1 A A 22 -0.357 15.590 3.656 1.00 1.00 N +ATOM 711 C2 A A 22 -0.878 16.653 3.057 1.00 1.00 C +ATOM 712 N3 A A 22 -2.091 17.171 3.178 1.00 1.00 N +ATOM 713 C4 A A 22 -2.823 16.449 4.052 1.00 1.00 C +ATOM 714 H5' A A 22 -8.880 15.972 3.710 1.00 1.00 H +ATOM 715 H5'' A A 22 -7.385 15.319 4.413 1.00 1.00 H +ATOM 716 H4' A A 22 -7.910 18.202 3.615 1.00 1.00 H +ATOM 717 H3' A A 22 -6.424 15.953 2.307 1.00 1.00 H +ATOM 718 H2' A A 22 -4.489 17.210 1.943 1.00 1.00 H +ATOM 719 HO2' A A 22 -4.667 19.619 2.303 1.00 1.00 H +ATOM 720 H1' A A 22 -4.459 18.747 4.211 1.00 1.00 H +ATOM 721 H8 A A 22 -5.407 15.621 5.804 1.00 1.00 H +ATOM 722 H61 A A 22 0.357 13.542 4.936 1.00 1.00 H +ATOM 723 H62 A A 22 -1.155 13.292 5.781 1.00 1.00 H +ATOM 724 H2 A A 22 -0.214 17.173 2.366 1.00 1.00 H +ATOM 725 P A A 23 -7.807 16.613 0.094 1.00 1.00 P +ATOM 726 OP1 A A 23 -8.670 17.411 -0.804 1.00 1.00 O +ATOM 727 OP2 A A 23 -8.296 15.324 0.630 1.00 1.00 O +ATOM 728 O5' A A 23 -6.407 16.346 -0.661 1.00 1.00 O +ATOM 729 C5' A A 23 -5.895 17.294 -1.605 1.00 1.00 C +ATOM 730 C4' A A 23 -4.478 16.938 -2.055 1.00 1.00 C +ATOM 731 O4' A A 23 -3.601 16.999 -0.928 1.00 1.00 O +ATOM 732 C3' A A 23 -4.344 15.542 -2.660 1.00 1.00 C +ATOM 733 O3' A A 23 -4.333 15.631 -4.090 1.00 1.00 O +ATOM 734 C2' A A 23 -2.985 15.066 -2.175 1.00 1.00 C +ATOM 735 O2' A A 23 -1.948 15.403 -3.104 1.00 1.00 O +ATOM 736 C1' A A 23 -2.813 15.805 -0.860 1.00 1.00 C +ATOM 737 N9 A A 23 -3.261 15.033 0.312 1.00 1.00 N +ATOM 738 C8 A A 23 -4.528 14.873 0.809 1.00 1.00 C +ATOM 739 N7 A A 23 -4.589 14.106 1.865 1.00 1.00 N +ATOM 740 C5 A A 23 -3.266 13.733 2.080 1.00 1.00 C +ATOM 741 C6 A A 23 -2.652 12.919 3.049 1.00 1.00 C +ATOM 742 N6 A A 23 -3.326 12.305 4.023 1.00 1.00 N +ATOM 743 N1 A A 23 -1.321 12.764 2.968 1.00 1.00 N +ATOM 744 C2 A A 23 -0.655 13.373 1.996 1.00 1.00 C +ATOM 745 N3 A A 23 -1.113 14.156 1.033 1.00 1.00 N +ATOM 746 C4 A A 23 -2.451 14.294 1.139 1.00 1.00 C +ATOM 747 H5' A A 23 -5.882 18.282 -1.144 1.00 1.00 H +ATOM 748 H5'' A A 23 -6.548 17.317 -2.475 1.00 1.00 H +ATOM 749 H4' A A 23 -4.147 17.673 -2.788 1.00 1.00 H +ATOM 750 H3' A A 23 -5.139 14.884 -2.307 1.00 1.00 H +ATOM 751 H2' A A 23 -3.007 13.989 -1.994 1.00 1.00 H +ATOM 752 HO2' A A 23 -2.372 15.639 -3.933 1.00 1.00 H +ATOM 753 H1' A A 23 -1.765 16.074 -0.731 1.00 1.00 H +ATOM 754 H8 A A 23 -5.405 15.344 0.365 1.00 1.00 H +ATOM 755 H61 A A 23 -2.831 11.731 4.691 1.00 1.00 H +ATOM 756 H62 A A 23 -4.334 12.413 4.095 1.00 1.00 H +ATOM 757 H2 A A 23 0.423 13.204 1.990 1.00 1.00 H +ATOM 758 P C A 24 -5.198 14.604 -4.982 1.00 1.00 P +ATOM 759 OP1 C A 24 -5.000 14.950 -6.407 1.00 1.00 O +ATOM 760 OP2 C A 24 -6.566 14.547 -4.420 1.00 1.00 O +ATOM 761 O5' C A 24 -4.478 13.188 -4.703 1.00 1.00 O +ATOM 762 C5' C A 24 -3.147 12.940 -5.165 1.00 1.00 C +ATOM 763 C4' C A 24 -2.472 11.828 -4.365 1.00 1.00 C +ATOM 764 O4' C A 24 -2.533 12.136 -2.973 1.00 1.00 O +ATOM 765 C3' C A 24 -3.105 10.452 -4.536 1.00 1.00 C +ATOM 766 O3' C A 24 -2.449 9.741 -5.591 1.00 1.00 O +ATOM 767 C2' C A 24 -2.824 9.769 -3.209 1.00 1.00 C +ATOM 768 O2' C A 24 -1.596 9.034 -3.250 1.00 1.00 O +ATOM 769 C1' C A 24 -2.745 10.929 -2.225 1.00 1.00 C +ATOM 770 N1 C A 24 -3.967 11.108 -1.424 1.00 1.00 N +ATOM 771 C2 C A 24 -4.114 10.305 -0.303 1.00 1.00 C +ATOM 772 O2 C A 24 -3.248 9.478 -0.023 1.00 1.00 O +ATOM 773 N3 C A 24 -5.229 10.461 0.462 1.00 1.00 N +ATOM 774 C4 C A 24 -6.162 11.367 0.139 1.00 1.00 C +ATOM 775 N4 C A 24 -7.244 11.495 0.911 1.00 1.00 N +ATOM 776 C5 C A 24 -6.015 12.197 -1.016 1.00 1.00 C +ATOM 777 C6 C A 24 -4.909 12.035 -1.767 1.00 1.00 C +ATOM 778 H5' C A 24 -2.561 13.854 -5.067 1.00 1.00 H +ATOM 779 H5'' C A 24 -3.183 12.652 -6.216 1.00 1.00 H +ATOM 780 H4' C A 24 -1.426 11.771 -4.657 1.00 1.00 H +ATOM 781 H3' C A 24 -4.178 10.534 -4.714 1.00 1.00 H +ATOM 782 H2' C A 24 -3.657 9.115 -2.944 1.00 1.00 H +ATOM 783 HO2' C A 24 -1.036 9.450 -3.909 1.00 1.00 H +ATOM 784 H1' C A 24 -1.902 10.774 -1.553 1.00 1.00 H +ATOM 785 H41 C A 24 -7.353 10.915 1.725 1.00 1.00 H +ATOM 786 H42 C A 24 -7.953 12.176 0.676 1.00 1.00 H +ATOM 787 H5 C A 24 -6.773 12.935 -1.281 1.00 1.00 H +ATOM 788 H6 C A 24 -4.762 12.651 -2.654 1.00 1.00 H +ATOM 789 P U A 25 -3.195 8.532 -6.353 1.00 1.00 P +ATOM 790 OP1 U A 25 -2.291 8.027 -7.412 1.00 1.00 O +ATOM 791 OP2 U A 25 -4.561 8.979 -6.701 1.00 1.00 O +ATOM 792 O5' U A 25 -3.309 7.403 -5.207 1.00 1.00 O +ATOM 793 C5' U A 25 -2.133 6.842 -4.614 1.00 1.00 C +ATOM 794 C4' U A 25 -2.474 5.908 -3.451 1.00 1.00 C +ATOM 795 O4' U A 25 -3.114 6.634 -2.405 1.00 1.00 O +ATOM 796 C3' U A 25 -3.412 4.768 -3.810 1.00 1.00 C +ATOM 797 O3' U A 25 -2.653 3.641 -4.259 1.00 1.00 O +ATOM 798 C2' U A 25 -4.092 4.442 -2.489 1.00 1.00 C +ATOM 799 O2' U A 25 -3.420 3.379 -1.807 1.00 1.00 O +ATOM 800 C1' U A 25 -4.008 5.754 -1.704 1.00 1.00 C +ATOM 801 N1 U A 25 -5.304 6.454 -1.568 1.00 1.00 N +ATOM 802 C2 U A 25 -6.046 6.222 -0.425 1.00 1.00 C +ATOM 803 O2 U A 25 -5.662 5.461 0.461 1.00 1.00 O +ATOM 804 N3 U A 25 -7.251 6.897 -0.335 1.00 1.00 N +ATOM 805 C4 U A 25 -7.770 7.770 -1.276 1.00 1.00 C +ATOM 806 O4 U A 25 -8.856 8.317 -1.092 1.00 1.00 O +ATOM 807 C5 U A 25 -6.927 7.953 -2.437 1.00 1.00 C +ATOM 808 C6 U A 25 -5.743 7.303 -2.547 1.00 1.00 C +ATOM 809 H5' U A 25 -1.501 7.651 -4.247 1.00 1.00 H +ATOM 810 H5'' U A 25 -1.588 6.280 -5.372 1.00 1.00 H +ATOM 811 H4' U A 25 -1.549 5.490 -3.058 1.00 1.00 H +ATOM 812 H3' U A 25 -4.141 5.084 -4.558 1.00 1.00 H +ATOM 813 H2' U A 25 -5.137 4.186 -2.664 1.00 1.00 H +ATOM 814 HO2' U A 25 -3.188 3.702 -0.932 1.00 1.00 H +ATOM 815 H1' U A 25 -3.603 5.550 -0.713 1.00 1.00 H +ATOM 816 H3 U A 25 -7.804 6.737 0.495 1.00 1.00 H +ATOM 817 H5 U A 25 -7.250 8.623 -3.234 1.00 1.00 H +ATOM 818 H6 U A 25 -5.130 7.459 -3.434 1.00 1.00 H +ATOM 819 P U A 26 -3.355 2.444 -5.077 1.00 1.00 P +ATOM 820 OP1 U A 26 -2.306 1.713 -5.821 1.00 1.00 O +ATOM 821 OP2 U A 26 -4.521 3.000 -5.801 1.00 1.00 O +ATOM 822 O5' U A 26 -3.902 1.486 -3.902 1.00 1.00 O +ATOM 823 C5' U A 26 -2.997 0.896 -2.963 1.00 1.00 C +ATOM 824 C4' U A 26 -3.739 0.308 -1.764 1.00 1.00 C +ATOM 825 O4' U A 26 -4.415 1.345 -1.050 1.00 1.00 O +ATOM 826 C3' U A 26 -4.796 -0.720 -2.124 1.00 1.00 C +ATOM 827 O3' U A 26 -4.213 -2.033 -2.158 1.00 1.00 O +ATOM 828 C2' U A 26 -5.795 -0.609 -0.982 1.00 1.00 C +ATOM 829 O2' U A 26 -5.509 -1.537 0.066 1.00 1.00 O +ATOM 830 C1' U A 26 -5.638 0.823 -0.496 1.00 1.00 C +ATOM 831 N1 U A 26 -6.743 1.696 -0.932 1.00 1.00 N +ATOM 832 C2 U A 26 -7.797 1.900 -0.062 1.00 1.00 C +ATOM 833 O2 U A 26 -7.841 1.373 1.048 1.00 1.00 O +ATOM 834 N3 U A 26 -8.806 2.731 -0.514 1.00 1.00 N +ATOM 835 C4 U A 26 -8.851 3.367 -1.744 1.00 1.00 C +ATOM 836 O4 U A 26 -9.800 4.088 -2.043 1.00 1.00 O +ATOM 837 C5 U A 26 -7.708 3.097 -2.588 1.00 1.00 C +ATOM 838 C6 U A 26 -6.707 2.286 -2.166 1.00 1.00 C +ATOM 839 H5' U A 26 -2.301 1.657 -2.612 1.00 1.00 H +ATOM 840 H5'' U A 26 -2.439 0.101 -3.459 1.00 1.00 H +ATOM 841 H4' U A 26 -3.014 -0.153 -1.095 1.00 1.00 H +ATOM 842 H3' U A 26 -5.269 -0.471 -3.077 1.00 1.00 H +ATOM 843 H2' U A 26 -6.806 -0.746 -1.364 1.00 1.00 H +ATOM 844 HO2' U A 26 -6.237 -1.492 0.691 1.00 1.00 H +ATOM 845 H1' U A 26 -5.573 0.832 0.593 1.00 1.00 H +ATOM 846 H3 U A 26 -9.584 2.890 0.111 1.00 1.00 H +ATOM 847 H5 U A 26 -7.652 3.548 -3.578 1.00 1.00 H +ATOM 848 H6 U A 26 -5.857 2.101 -2.823 1.00 1.00 H +ATOM 849 P G A 27 -4.928 -3.235 -2.964 1.00 1.00 P +ATOM 850 OP1 G A 27 -4.032 -4.413 -2.938 1.00 1.00 O +ATOM 851 OP2 G A 27 -5.414 -2.703 -4.254 1.00 1.00 O +ATOM 852 O5' G A 27 -6.205 -3.552 -2.041 1.00 1.00 O +ATOM 853 C5' G A 27 -6.022 -3.869 -0.664 1.00 1.00 C +ATOM 854 C4' G A 27 -7.288 -3.609 0.143 1.00 1.00 C +ATOM 855 O4' G A 27 -7.771 -2.299 -0.150 1.00 1.00 O +ATOM 856 C3' G A 27 -8.442 -4.557 -0.146 1.00 1.00 C +ATOM 857 O3' G A 27 -8.384 -5.672 0.755 1.00 1.00 O +ATOM 858 C2' G A 27 -9.669 -3.720 0.174 1.00 1.00 C +ATOM 859 O2' G A 27 -10.149 -3.994 1.494 1.00 1.00 O +ATOM 860 C1' G A 27 -9.187 -2.276 0.047 1.00 1.00 C +ATOM 861 N9 G A 27 -9.823 -1.530 -1.054 1.00 1.00 N +ATOM 862 C8 G A 27 -9.368 -1.280 -2.324 1.00 1.00 C +ATOM 863 N7 G A 27 -10.178 -0.552 -3.040 1.00 1.00 N +ATOM 864 C5 G A 27 -11.248 -0.300 -2.185 1.00 1.00 C +ATOM 865 C6 G A 27 -12.439 0.444 -2.408 1.00 1.00 C +ATOM 866 O6 G A 27 -12.786 1.043 -3.423 1.00 1.00 O +ATOM 867 N1 G A 27 -13.256 0.446 -1.285 1.00 1.00 N +ATOM 868 C2 G A 27 -12.965 -0.187 -0.095 1.00 1.00 C +ATOM 869 N2 G A 27 -13.876 -0.076 0.870 1.00 1.00 N +ATOM 870 N3 G A 27 -11.845 -0.884 0.116 1.00 1.00 N +ATOM 871 C4 G A 27 -11.037 -0.898 -0.969 1.00 1.00 C +ATOM 872 H5' G A 27 -5.214 -3.255 -0.264 1.00 1.00 H +ATOM 873 H5'' G A 27 -5.751 -4.920 -0.573 1.00 1.00 H +ATOM 874 H4' G A 27 -7.049 -3.656 1.202 1.00 1.00 H +ATOM 875 H3' G A 27 -8.438 -4.878 -1.191 1.00 1.00 H +ATOM 876 H2' G A 27 -10.451 -3.916 -0.565 1.00 1.00 H +ATOM 877 HO2' G A 27 -9.397 -4.280 2.020 1.00 1.00 H +ATOM 878 H1' G A 27 -9.394 -1.752 0.977 1.00 1.00 H +ATOM 879 H8 G A 27 -8.419 -1.661 -2.702 1.00 1.00 H +ATOM 880 H1 G A 27 -14.123 0.957 -1.367 1.00 1.00 H +ATOM 881 H21 G A 27 -14.724 0.452 0.708 1.00 1.00 H +ATOM 882 H22 G A 27 -13.718 -0.519 1.763 1.00 1.00 H +ATOM 883 P G A 28 -9.309 -6.974 0.526 1.00 1.00 P +ATOM 884 OP1 G A 28 -8.662 -8.123 1.200 1.00 1.00 O +ATOM 885 OP2 G A 28 -9.637 -7.058 -0.915 1.00 1.00 O +ATOM 886 O5' G A 28 -10.665 -6.617 1.331 1.00 1.00 O +ATOM 887 C5' G A 28 -10.740 -6.764 2.756 1.00 1.00 C +ATOM 888 C4' G A 28 -12.190 -6.869 3.245 1.00 1.00 C +ATOM 889 O4' G A 28 -12.759 -5.562 3.403 1.00 1.00 O +ATOM 890 C3' G A 28 -13.103 -7.648 2.304 1.00 1.00 C +ATOM 891 O3' G A 28 -13.226 -8.999 2.758 1.00 1.00 O +ATOM 892 C2' G A 28 -14.441 -6.936 2.426 1.00 1.00 C +ATOM 893 O2' G A 28 -15.243 -7.495 3.470 1.00 1.00 O +ATOM 894 C1' G A 28 -14.031 -5.506 2.740 1.00 1.00 C +ATOM 895 N9 G A 28 -13.857 -4.670 1.545 1.00 1.00 N +ATOM 896 C8 G A 28 -12.682 -4.267 0.967 1.00 1.00 C +ATOM 897 N7 G A 28 -12.840 -3.547 -0.107 1.00 1.00 N +ATOM 898 C5 G A 28 -14.220 -3.463 -0.255 1.00 1.00 C +ATOM 899 C6 G A 28 -14.989 -2.802 -1.252 1.00 1.00 C +ATOM 900 O6 G A 28 -14.593 -2.154 -2.219 1.00 1.00 O +ATOM 901 N1 G A 28 -16.351 -2.964 -1.034 1.00 1.00 N +ATOM 902 C2 G A 28 -16.906 -3.670 0.010 1.00 1.00 C +ATOM 903 N2 G A 28 -18.237 -3.712 0.049 1.00 1.00 N +ATOM 904 N3 G A 28 -16.185 -4.292 0.949 1.00 1.00 N +ATOM 905 C4 G A 28 -14.854 -4.147 0.753 1.00 1.00 C +ATOM 906 H5' G A 28 -10.270 -5.901 3.227 1.00 1.00 H +ATOM 907 H5'' G A 28 -10.200 -7.665 3.050 1.00 1.00 H +ATOM 908 H4' G A 28 -12.192 -7.362 4.216 1.00 1.00 H +ATOM 909 H3' G A 28 -12.730 -7.604 1.279 1.00 1.00 H +ATOM 910 H2' G A 28 -14.968 -6.965 1.472 1.00 1.00 H +ATOM 911 HO2' G A 28 -16.155 -7.479 3.168 1.00 1.00 H +ATOM 912 H1' G A 28 -14.770 -5.050 3.398 1.00 1.00 H +ATOM 913 H8 G A 28 -11.703 -4.523 1.373 1.00 1.00 H +ATOM 914 H1 G A 28 -16.963 -2.520 -1.705 1.00 1.00 H +ATOM 915 H21 G A 28 -18.778 -3.242 -0.663 1.00 1.00 H +ATOM 916 H22 G A 28 -18.705 -4.214 0.789 1.00 1.00 H +ATOM 917 P U A 29 -13.372 -10.210 1.705 1.00 1.00 P +ATOM 918 OP1 U A 29 -13.342 -11.482 2.461 1.00 1.00 O +ATOM 919 OP2 U A 29 -12.405 -9.982 0.607 1.00 1.00 O +ATOM 920 O5' U A 29 -14.860 -10.006 1.118 1.00 1.00 O +ATOM 921 C5' U A 29 -16.006 -10.387 1.888 1.00 1.00 C +ATOM 922 C4' U A 29 -17.307 -10.157 1.121 1.00 1.00 C +ATOM 923 O4' U A 29 -17.486 -8.764 0.862 1.00 1.00 O +ATOM 924 C3' U A 29 -17.373 -10.852 -0.228 1.00 1.00 C +ATOM 925 O3' U A 29 -17.925 -12.164 -0.084 1.00 1.00 O +ATOM 926 C2' U A 29 -18.322 -9.976 -1.024 1.00 1.00 C +ATOM 927 O2' U A 29 -19.678 -10.420 -0.906 1.00 1.00 O +ATOM 928 C1' U A 29 -18.129 -8.597 -0.415 1.00 1.00 C +ATOM 929 N1 U A 29 -17.276 -7.716 -1.238 1.00 1.00 N +ATOM 930 C2 U A 29 -17.890 -6.942 -2.204 1.00 1.00 C +ATOM 931 O2 U A 29 -19.103 -6.984 -2.403 1.00 1.00 O +ATOM 932 N3 U A 29 -17.059 -6.113 -2.936 1.00 1.00 N +ATOM 933 C4 U A 29 -15.688 -5.996 -2.789 1.00 1.00 C +ATOM 934 O4 U A 29 -15.046 -5.224 -3.498 1.00 1.00 O +ATOM 935 C5 U A 29 -15.132 -6.841 -1.757 1.00 1.00 C +ATOM 936 C6 U A 29 -15.926 -7.662 -1.026 1.00 1.00 C +ATOM 937 H5' U A 29 -16.027 -9.800 2.807 1.00 1.00 H +ATOM 938 H5'' U A 29 -15.926 -11.443 2.144 1.00 1.00 H +ATOM 939 H4' U A 29 -18.139 -10.500 1.734 1.00 1.00 H +ATOM 940 H3' U A 29 -16.388 -10.882 -0.697 1.00 1.00 H +ATOM 941 H2' U A 29 -18.016 -9.949 -2.060 1.00 1.00 H +ATOM 942 HO2' U A 29 -19.737 -10.946 -0.107 1.00 1.00 H +ATOM 943 H1' U A 29 -19.101 -8.129 -0.273 1.00 1.00 H +ATOM 944 H3 U A 29 -17.494 -5.541 -3.646 1.00 1.00 H +ATOM 945 H5 U A 29 -14.060 -6.820 -1.564 1.00 1.00 H +ATOM 946 H6 U A 29 -15.480 -8.289 -0.255 1.00 1.00 H +ATOM 947 P U A 30 -17.605 -13.308 -1.174 1.00 1.00 P +ATOM 948 OP1 U A 30 -18.229 -14.569 -0.714 1.00 1.00 O +ATOM 949 OP2 U A 30 -16.156 -13.269 -1.471 1.00 1.00 O +ATOM 950 O5' U A 30 -18.401 -12.805 -2.483 1.00 1.00 O +ATOM 951 C5' U A 30 -19.830 -12.854 -2.535 1.00 1.00 C +ATOM 952 C4' U A 30 -20.351 -12.589 -3.947 1.00 1.00 C +ATOM 953 O4' U A 30 -20.350 -11.189 -4.210 1.00 1.00 O +ATOM 954 C3' U A 30 -19.527 -13.231 -5.051 1.00 1.00 C +ATOM 955 O3' U A 30 -20.004 -14.554 -5.318 1.00 1.00 O +ATOM 956 C2' U A 30 -19.798 -12.323 -6.240 1.00 1.00 C +ATOM 957 O2' U A 30 -20.982 -12.718 -6.944 1.00 1.00 O +ATOM 958 C1' U A 30 -19.973 -10.957 -5.577 1.00 1.00 C +ATOM 959 N1 U A 30 -18.744 -10.148 -5.555 1.00 1.00 N +ATOM 960 C2 U A 30 -18.606 -9.164 -6.516 1.00 1.00 C +ATOM 961 O2 U A 30 -19.448 -8.984 -7.393 1.00 1.00 O +ATOM 962 N3 U A 30 -17.461 -8.393 -6.435 1.00 1.00 N +ATOM 963 C4 U A 30 -16.457 -8.517 -5.489 1.00 1.00 C +ATOM 964 O4 U A 30 -15.480 -7.773 -5.511 1.00 1.00 O +ATOM 965 C5 U A 30 -16.685 -9.570 -4.524 1.00 1.00 C +ATOM 966 C6 U A 30 -17.799 -10.339 -4.584 1.00 1.00 C +ATOM 967 H5' U A 30 -20.233 -12.096 -1.862 1.00 1.00 H +ATOM 968 H5'' U A 30 -20.167 -13.837 -2.206 1.00 1.00 H +ATOM 969 H4' U A 30 -21.376 -12.949 -4.018 1.00 1.00 H +ATOM 970 H3' U A 30 -18.467 -13.231 -4.794 1.00 1.00 H +ATOM 971 H2' U A 30 -18.931 -12.311 -6.907 1.00 1.00 H +ATOM 972 HO2' U A 30 -20.998 -12.232 -7.772 1.00 1.00 H +ATOM 973 H1' U A 30 -20.764 -10.398 -6.076 1.00 1.00 H +ATOM 974 H3 U A 30 -17.346 -7.670 -7.130 1.00 1.00 H +ATOM 975 H5 U A 30 -15.950 -9.748 -3.739 1.00 1.00 H +ATOM 976 H6 U A 30 -17.946 -11.125 -3.842 1.00 1.00 H +ATOM 977 P C A 31 -18.989 -15.688 -5.849 1.00 1.00 P +ATOM 978 OP1 C A 31 -19.745 -16.953 -5.990 1.00 1.00 O +ATOM 979 OP2 C A 31 -17.770 -15.648 -5.012 1.00 1.00 O +ATOM 980 O5' C A 31 -18.607 -15.165 -7.326 1.00 1.00 O +ATOM 981 C5' C A 31 -19.594 -15.145 -8.360 1.00 1.00 C +ATOM 982 C4' C A 31 -19.217 -14.194 -9.492 1.00 1.00 C +ATOM 983 O4' C A 31 -18.995 -12.889 -8.978 1.00 1.00 O +ATOM 984 C3' C A 31 -17.946 -14.549 -10.234 1.00 1.00 C +ATOM 985 O3' C A 31 -18.234 -15.522 -11.245 1.00 1.00 O +ATOM 986 C2' C A 31 -17.572 -13.213 -10.872 1.00 1.00 C +ATOM 987 O2' C A 31 -18.141 -13.085 -12.179 1.00 1.00 O +ATOM 988 C1' C A 31 -18.154 -12.177 -9.899 1.00 1.00 C +ATOM 989 N1 C A 31 -17.132 -11.460 -9.106 1.00 1.00 N +ATOM 990 C2 C A 31 -16.774 -10.191 -9.527 1.00 1.00 C +ATOM 991 O2 C A 31 -17.280 -9.712 -10.540 1.00 1.00 O +ATOM 992 N3 C A 31 -15.856 -9.501 -8.796 1.00 1.00 N +ATOM 993 C4 C A 31 -15.313 -10.035 -7.694 1.00 1.00 C +ATOM 994 N4 C A 31 -14.417 -9.333 -7.000 1.00 1.00 N +ATOM 995 C5 C A 31 -15.680 -11.347 -7.253 1.00 1.00 C +ATOM 996 C6 C A 31 -16.589 -12.021 -7.986 1.00 1.00 C +ATOM 997 H5' C A 31 -20.546 -14.828 -7.934 1.00 1.00 H +ATOM 998 H5'' C A 31 -19.703 -16.150 -8.764 1.00 1.00 H +ATOM 999 H4' C A 31 -20.039 -14.146 -10.204 1.00 1.00 H +ATOM 1000 H3' C A 31 -17.171 -14.891 -9.545 1.00 1.00 H +ATOM 1001 H2' C A 31 -16.492 -13.111 -10.913 1.00 1.00 H +ATOM 1002 HO2' C A 31 -17.612 -13.621 -12.774 1.00 1.00 H +ATOM 1003 H1' C A 31 -18.756 -11.451 -10.449 1.00 1.00 H +ATOM 1004 H41 C A 31 -14.161 -8.417 -7.300 1.00 1.00 H +ATOM 1005 H42 C A 31 -14.002 -9.726 -6.167 1.00 1.00 H +ATOM 1006 H5 C A 31 -15.241 -11.784 -6.357 1.00 1.00 H +ATOM 1007 H6 C A 31 -16.894 -13.022 -7.679 1.00 1.00 H +ATOM 1008 P U A 32 -17.341 -16.857 -11.378 1.00 1.00 P +ATOM 1009 OP1 U A 32 -18.180 -17.909 -11.996 1.00 1.00 O +ATOM 1010 OP2 U A 32 -16.687 -17.109 -10.076 1.00 1.00 O +ATOM 1011 O5' U A 32 -16.204 -16.430 -12.435 1.00 1.00 O +ATOM 1012 C5' U A 32 -16.556 -15.750 -13.640 1.00 1.00 C +ATOM 1013 C4' U A 32 -15.569 -14.632 -13.969 1.00 1.00 C +ATOM 1014 O4' U A 32 -15.554 -13.665 -12.925 1.00 1.00 O +ATOM 1015 C3' U A 32 -14.123 -15.077 -14.136 1.00 1.00 C +ATOM 1016 O3' U A 32 -13.891 -15.479 -15.491 1.00 1.00 O +ATOM 1017 C2' U A 32 -13.341 -13.806 -13.838 1.00 1.00 C +ATOM 1018 O2' U A 32 -13.014 -13.100 -15.039 1.00 1.00 O +ATOM 1019 C1' U A 32 -14.287 -12.993 -12.951 1.00 1.00 C +ATOM 1020 N1 U A 32 -13.809 -12.827 -11.560 1.00 1.00 N +ATOM 1021 C2 U A 32 -13.074 -11.692 -11.277 1.00 1.00 C +ATOM 1022 O2 U A 32 -12.810 -10.853 -12.136 1.00 1.00 O +ATOM 1023 N3 U A 32 -12.650 -11.554 -9.968 1.00 1.00 N +ATOM 1024 C4 U A 32 -12.894 -12.441 -8.932 1.00 1.00 C +ATOM 1025 O4 U A 32 -12.469 -12.216 -7.801 1.00 1.00 O +ATOM 1026 C5 U A 32 -13.668 -13.599 -9.320 1.00 1.00 C +ATOM 1027 C6 U A 32 -14.095 -13.756 -10.595 1.00 1.00 C +ATOM 1028 H5' U A 32 -17.553 -15.322 -13.527 1.00 1.00 H +ATOM 1029 H5'' U A 32 -16.569 -16.466 -14.461 1.00 1.00 H +ATOM 1030 H4' U A 32 -15.892 -14.139 -14.883 1.00 1.00 H +ATOM 1031 H3' U A 32 -13.872 -15.870 -13.429 1.00 1.00 H +ATOM 1032 H2' U A 32 -12.438 -14.051 -13.279 1.00 1.00 H +ATOM 1033 HO2' U A 32 -13.273 -12.183 -14.911 1.00 1.00 H +ATOM 1034 H1' U A 32 -14.426 -12.008 -13.400 1.00 1.00 H +ATOM 1035 H3 U A 32 -12.112 -10.728 -9.745 1.00 1.00 H +ATOM 1036 H5 U A 32 -13.911 -14.357 -8.575 1.00 1.00 H +ATOM 1037 H6 U A 32 -14.676 -14.639 -10.859 1.00 1.00 H +ATOM 1038 P U A 33 -12.688 -16.485 -15.862 1.00 1.00 P +ATOM 1039 OP1 U A 33 -12.787 -16.805 -17.304 1.00 1.00 O +ATOM 1040 OP2 U A 33 -12.678 -17.579 -14.866 1.00 1.00 O +ATOM 1041 O5' U A 33 -11.365 -15.586 -15.639 1.00 1.00 O +ATOM 1042 C5' U A 33 -11.057 -14.510 -16.531 1.00 1.00 C +ATOM 1043 C4' U A 33 -9.890 -13.660 -16.026 1.00 1.00 C +ATOM 1044 O4' U A 33 -10.207 -13.098 -14.758 1.00 1.00 O +ATOM 1045 C3' U A 33 -8.587 -14.416 -15.832 1.00 1.00 C +ATOM 1046 O3' U A 33 -7.835 -14.397 -17.050 1.00 1.00 O +ATOM 1047 C2' U A 33 -7.862 -13.605 -14.766 1.00 1.00 C +ATOM 1048 O2' U A 33 -6.949 -12.673 -15.354 1.00 1.00 O +ATOM 1049 C1' U A 33 -8.990 -12.885 -14.022 1.00 1.00 C +ATOM 1050 N1 U A 33 -9.209 -13.375 -12.645 1.00 1.00 N +ATOM 1051 C2 U A 33 -8.620 -12.674 -11.609 1.00 1.00 C +ATOM 1052 O2 U A 33 -7.926 -11.678 -11.805 1.00 1.00 O +ATOM 1053 N3 U A 33 -8.857 -13.159 -10.336 1.00 1.00 N +ATOM 1054 C4 U A 33 -9.620 -14.267 -10.013 1.00 1.00 C +ATOM 1055 O4 U A 33 -9.764 -14.610 -8.841 1.00 1.00 O +ATOM 1056 C5 U A 33 -10.198 -14.938 -11.156 1.00 1.00 C +ATOM 1057 C6 U A 33 -9.980 -14.481 -12.413 1.00 1.00 C +ATOM 1058 H5' U A 33 -11.938 -13.876 -16.644 1.00 1.00 H +ATOM 1059 H5'' U A 33 -10.794 -14.925 -17.504 1.00 1.00 H +ATOM 1060 H4' U A 33 -9.720 -12.843 -16.726 1.00 1.00 H +ATOM 1061 H3' U A 33 -8.774 -15.436 -15.492 1.00 1.00 H +ATOM 1062 H2' U A 33 -7.338 -14.278 -14.083 1.00 1.00 H +ATOM 1063 HO2' U A 33 -6.540 -13.110 -16.103 1.00 1.00 H +ATOM 1064 H1' U A 33 -8.775 -11.817 -13.997 1.00 1.00 H +ATOM 1065 H3 U A 33 -8.431 -12.657 -9.568 1.00 1.00 H +ATOM 1066 H5 U A 33 -10.817 -15.823 -11.005 1.00 1.00 H +ATOM 1067 H6 U A 33 -10.428 -15.006 -13.257 1.00 1.00 H +ATOM 1068 P C A 34 -6.618 -15.425 -17.278 1.00 1.00 P +ATOM 1069 OP1 C A 34 -6.044 -15.170 -18.619 1.00 1.00 O +ATOM 1070 OP2 C A 34 -7.083 -16.783 -16.920 1.00 1.00 O +ATOM 1071 O5' C A 34 -5.547 -14.948 -16.174 1.00 1.00 O +ATOM 1072 C5' C A 34 -4.716 -15.900 -15.504 1.00 1.00 C +ATOM 1073 C4' C A 34 -3.676 -15.212 -14.621 1.00 1.00 C +ATOM 1074 O4' C A 34 -4.331 -14.348 -13.693 1.00 1.00 O +ATOM 1075 C3' C A 34 -2.820 -16.171 -13.806 1.00 1.00 C +ATOM 1076 O3' C A 34 -1.593 -16.436 -14.495 1.00 1.00 O +ATOM 1077 C2' C A 34 -2.527 -15.412 -12.523 1.00 1.00 C +ATOM 1078 O2' C A 34 -1.248 -14.770 -12.578 1.00 1.00 O +ATOM 1079 C1' C A 34 -3.657 -14.394 -12.428 1.00 1.00 C +ATOM 1080 N1 C A 34 -4.659 -14.728 -11.402 1.00 1.00 N +ATOM 1081 C2 C A 34 -4.373 -14.383 -10.092 1.00 1.00 C +ATOM 1082 O2 C A 34 -3.315 -13.821 -9.821 1.00 1.00 O +ATOM 1083 N3 C A 34 -5.290 -14.682 -9.131 1.00 1.00 N +ATOM 1084 C4 C A 34 -6.440 -15.294 -9.444 1.00 1.00 C +ATOM 1085 N4 C A 34 -7.316 -15.571 -8.479 1.00 1.00 N +ATOM 1086 C5 C A 34 -6.740 -15.652 -10.797 1.00 1.00 C +ATOM 1087 C6 C A 34 -5.826 -15.352 -11.740 1.00 1.00 C +ATOM 1088 H5' C A 34 -4.204 -16.510 -16.247 1.00 1.00 H +ATOM 1089 H5'' C A 34 -5.341 -16.542 -14.883 1.00 1.00 H +ATOM 1090 H4' C A 34 -3.026 -14.610 -15.251 1.00 1.00 H +ATOM 1091 H3' C A 34 -3.364 -17.094 -13.596 1.00 1.00 H +ATOM 1092 H2' C A 34 -2.578 -16.093 -11.675 1.00 1.00 H +ATOM 1093 HO2' C A 34 -1.379 -13.851 -12.333 1.00 1.00 H +ATOM 1094 H1' C A 34 -3.239 -13.413 -12.207 1.00 1.00 H +ATOM 1095 H41 C A 34 -7.109 -15.320 -7.523 1.00 1.00 H +ATOM 1096 H42 C A 34 -8.186 -16.033 -8.704 1.00 1.00 H +ATOM 1097 H5 C A 34 -7.674 -16.149 -11.055 1.00 1.00 H +ATOM 1098 H6 C A 34 -6.020 -15.609 -12.781 1.00 1.00 H +ATOM 1099 P C A 35 -0.702 -17.720 -14.105 1.00 1.00 P +ATOM 1100 OP1 C A 35 0.397 -17.836 -15.092 1.00 1.00 O +ATOM 1101 OP2 C A 35 -1.612 -18.864 -13.881 1.00 1.00 O +ATOM 1102 O5' C A 35 -0.059 -17.302 -12.687 1.00 1.00 O +ATOM 1103 C5' C A 35 0.897 -16.239 -12.601 1.00 1.00 C +ATOM 1104 C4' C A 35 1.402 -16.045 -11.172 1.00 1.00 C +ATOM 1105 O4' C A 35 0.352 -15.571 -10.336 1.00 1.00 O +ATOM 1106 C3' C A 35 1.929 -17.307 -10.515 1.00 1.00 C +ATOM 1107 O3' C A 35 3.328 -17.446 -10.785 1.00 1.00 O +ATOM 1108 C2' C A 35 1.707 -17.059 -9.026 1.00 1.00 C +ATOM 1109 O2' C A 35 2.897 -16.569 -8.398 1.00 1.00 O +ATOM 1110 C1' C A 35 0.587 -16.017 -8.989 1.00 1.00 C +ATOM 1111 N1 C A 35 -0.696 -16.527 -8.455 1.00 1.00 N +ATOM 1112 C2 C A 35 -0.971 -16.306 -7.115 1.00 1.00 C +ATOM 1113 O2 C A 35 -0.156 -15.713 -6.409 1.00 1.00 O +ATOM 1114 N3 C A 35 -2.152 -16.760 -6.614 1.00 1.00 N +ATOM 1115 C4 C A 35 -3.028 -17.405 -7.396 1.00 1.00 C +ATOM 1116 N4 C A 35 -4.176 -17.837 -6.875 1.00 1.00 N +ATOM 1117 C5 C A 35 -2.748 -17.636 -8.780 1.00 1.00 C +ATOM 1118 C6 C A 35 -1.576 -17.183 -9.266 1.00 1.00 C +ATOM 1119 H5' C A 35 0.432 -15.312 -12.944 1.00 1.00 H +ATOM 1120 H5'' C A 35 1.743 -16.471 -13.247 1.00 1.00 H +ATOM 1121 H4' C A 35 2.194 -15.298 -11.178 1.00 1.00 H +ATOM 1122 H3' C A 35 1.369 -18.182 -10.852 1.00 1.00 H +ATOM 1123 H2' C A 35 1.372 -17.981 -8.546 1.00 1.00 H +ATOM 1124 HO2' C A 35 3.194 -15.805 -8.900 1.00 1.00 H +ATOM 1125 H1' C A 35 0.914 -15.165 -8.388 1.00 1.00 H +ATOM 1126 H41 C A 35 -4.379 -17.676 -5.901 1.00 1.00 H +ATOM 1127 H42 C A 35 -4.843 -18.324 -7.455 1.00 1.00 H +ATOM 1128 H5 C A 35 -3.458 -18.162 -9.419 1.00 1.00 H +ATOM 1129 H6 C A 35 -1.329 -17.341 -10.315 1.00 1.00 H +ATOM 1130 P U A 36 4.047 -18.870 -10.589 1.00 1.00 P +ATOM 1131 OP1 U A 36 5.496 -18.636 -10.395 1.00 1.00 O +ATOM 1132 OP2 U A 36 3.581 -19.779 -11.659 1.00 1.00 O +ATOM 1133 O5' U A 36 3.421 -19.362 -9.193 1.00 1.00 O +ATOM 1134 C5' U A 36 4.096 -20.317 -8.376 1.00 1.00 C +ATOM 1135 C4' U A 36 4.058 -19.906 -6.906 1.00 1.00 C +ATOM 1136 O4' U A 36 2.835 -19.234 -6.626 1.00 1.00 O +ATOM 1137 C3' U A 36 4.161 -21.065 -5.927 1.00 1.00 C +ATOM 1138 O3' U A 36 5.529 -21.248 -5.554 1.00 1.00 O +ATOM 1139 C2' U A 36 3.351 -20.606 -4.723 1.00 1.00 C +ATOM 1140 O2' U A 36 4.199 -20.091 -3.695 1.00 1.00 O +ATOM 1141 C1' U A 36 2.431 -19.517 -5.281 1.00 1.00 C +ATOM 1142 N1 U A 36 1.007 -19.899 -5.315 1.00 1.00 N +ATOM 1143 C2 U A 36 0.359 -20.051 -4.105 1.00 1.00 C +ATOM 1144 O2 U A 36 0.933 -19.880 -3.031 1.00 1.00 O +ATOM 1145 N3 U A 36 -0.975 -20.408 -4.170 1.00 1.00 N +ATOM 1146 C4 U A 36 -1.708 -20.623 -5.326 1.00 1.00 C +ATOM 1147 O4 U A 36 -2.894 -20.937 -5.266 1.00 1.00 O +ATOM 1148 C5 U A 36 -0.951 -20.443 -6.544 1.00 1.00 C +ATOM 1149 C6 U A 36 0.358 -20.093 -6.505 1.00 1.00 C +ATOM 1150 H5' U A 36 5.134 -20.394 -8.698 1.00 1.00 H +ATOM 1151 H5'' U A 36 3.612 -21.286 -8.492 1.00 1.00 H +ATOM 1152 H4' U A 36 4.878 -19.215 -6.716 1.00 1.00 H +ATOM 1153 H3' U A 36 3.740 -21.978 -6.352 1.00 1.00 H +ATOM 1154 H2' U A 36 2.750 -21.437 -4.344 1.00 1.00 H +ATOM 1155 HO2' U A 36 3.633 -19.762 -2.994 1.00 1.00 H +ATOM 1156 H1' U A 36 2.540 -18.615 -4.677 1.00 1.00 H +ATOM 1157 H3 U A 36 -1.462 -20.522 -3.292 1.00 1.00 H +ATOM 1158 H5 U A 36 -1.439 -20.588 -7.507 1.00 1.00 H +ATOM 1159 H6 U A 36 0.905 -19.964 -7.439 1.00 1.00 H +ATOM 1160 P A A 37 6.081 -22.703 -5.148 1.00 1.00 P +ATOM 1161 OP1 A A 37 7.537 -22.596 -4.910 1.00 1.00 O +ATOM 1162 OP2 A A 37 5.563 -23.685 -6.127 1.00 1.00 O +ATOM 1163 O5' A A 37 5.357 -22.970 -3.736 1.00 1.00 O +ATOM 1164 C5' A A 37 5.545 -22.067 -2.644 1.00 1.00 C +ATOM 1165 C4' A A 37 4.876 -22.581 -1.372 1.00 1.00 C +ATOM 1166 O4' A A 37 3.453 -22.517 -1.524 1.00 1.00 O +ATOM 1167 C3' A A 37 5.241 -24.022 -1.026 1.00 1.00 C +ATOM 1168 O3' A A 37 5.432 -24.140 0.387 1.00 1.00 O +ATOM 1169 C2' A A 37 4.027 -24.832 -1.449 1.00 1.00 C +ATOM 1170 O2' A A 37 3.796 -25.928 -0.556 1.00 1.00 O +ATOM 1171 C1' A A 37 2.888 -23.826 -1.397 1.00 1.00 C +ATOM 1172 N9 A A 37 1.893 -23.988 -2.476 1.00 1.00 N +ATOM 1173 C8 A A 37 2.104 -24.130 -3.823 1.00 1.00 C +ATOM 1174 N7 A A 37 1.007 -24.254 -4.518 1.00 1.00 N +ATOM 1175 C5 A A 37 -0.002 -24.189 -3.562 1.00 1.00 C +ATOM 1176 C6 A A 37 -1.402 -24.257 -3.654 1.00 1.00 C +ATOM 1177 N6 A A 37 -2.051 -24.412 -4.809 1.00 1.00 N +ATOM 1178 N1 A A 37 -2.100 -24.158 -2.511 1.00 1.00 N +ATOM 1179 C2 A A 37 -1.447 -24.004 -1.364 1.00 1.00 C +ATOM 1180 N3 A A 37 -0.143 -23.926 -1.149 1.00 1.00 N +ATOM 1181 C4 A A 37 0.530 -24.028 -2.314 1.00 1.00 C +ATOM 1182 H5' A A 37 5.118 -21.099 -2.904 1.00 1.00 H +ATOM 1183 H5'' A A 37 6.612 -21.948 -2.460 1.00 1.00 H +ATOM 1184 H4' A A 37 5.162 -21.938 -0.542 1.00 1.00 H +ATOM 1185 H3' A A 37 6.131 -24.340 -1.573 1.00 1.00 H +ATOM 1186 H2' A A 37 4.159 -25.191 -2.474 1.00 1.00 H +ATOM 1187 HO2' A A 37 3.409 -26.639 -1.071 1.00 1.00 H +ATOM 1188 H1' A A 37 2.383 -23.906 -0.435 1.00 1.00 H +ATOM 1189 H8 A A 37 3.097 -24.138 -4.273 1.00 1.00 H +ATOM 1190 H61 A A 37 -3.060 -24.456 -4.819 1.00 1.00 H +ATOM 1191 H62 A A 37 -1.534 -24.488 -5.674 1.00 1.00 H +ATOM 1192 H2 A A 37 -2.075 -23.931 -0.475 1.00 1.00 H +ATOM 1193 P A A 38 6.432 -25.251 0.984 1.00 1.00 P +ATOM 1194 OP1 A A 38 7.779 -25.012 0.420 1.00 1.00 O +ATOM 1195 OP2 A A 38 5.794 -26.578 0.833 1.00 1.00 O +ATOM 1196 O5' A A 38 6.473 -24.885 2.553 1.00 1.00 O +ATOM 1197 C5' A A 38 5.745 -25.672 3.499 1.00 1.00 C +ATOM 1198 C4' A A 38 5.445 -24.883 4.775 1.00 1.00 C +ATOM 1199 O4' A A 38 5.162 -23.521 4.437 1.00 1.00 O +ATOM 1200 C3' A A 38 4.257 -25.420 5.578 1.00 1.00 C +ATOM 1201 O3' A A 38 4.738 -26.136 6.723 1.00 1.00 O +ATOM 1202 C2' A A 38 3.519 -24.169 6.027 1.00 1.00 C +ATOM 1203 O2' A A 38 3.959 -23.738 7.320 1.00 1.00 O +ATOM 1204 C1' A A 38 3.880 -23.155 4.952 1.00 1.00 C +ATOM 1205 N9 A A 38 2.943 -23.122 3.814 1.00 1.00 N +ATOM 1206 C8 A A 38 3.171 -23.465 2.506 1.00 1.00 C +ATOM 1207 N7 A A 38 2.130 -23.322 1.734 1.00 1.00 N +ATOM 1208 C5 A A 38 1.142 -22.850 2.593 1.00 1.00 C +ATOM 1209 C6 A A 38 -0.204 -22.498 2.391 1.00 1.00 C +ATOM 1210 N6 A A 38 -0.808 -22.571 1.204 1.00 1.00 N +ATOM 1211 N1 A A 38 -0.895 -22.068 3.460 1.00 1.00 N +ATOM 1212 C2 A A 38 -0.289 -21.997 4.639 1.00 1.00 C +ATOM 1213 N3 A A 38 0.961 -22.298 4.954 1.00 1.00 N +ATOM 1214 C4 A A 38 1.629 -22.725 3.862 1.00 1.00 C +ATOM 1215 H5' A A 38 6.334 -26.553 3.756 1.00 1.00 H +ATOM 1216 H5'' A A 38 4.807 -25.991 3.046 1.00 1.00 H +ATOM 1217 H4' A A 38 6.330 -24.899 5.409 1.00 1.00 H +ATOM 1218 H3' A A 38 3.614 -26.048 4.960 1.00 1.00 H +ATOM 1219 H2' A A 38 2.442 -24.349 6.023 1.00 1.00 H +ATOM 1220 HO2' A A 38 4.080 -22.786 7.277 1.00 1.00 H +ATOM 1221 H1' A A 38 3.939 -22.163 5.397 1.00 1.00 H +ATOM 1222 H8 A A 38 4.136 -23.824 2.145 1.00 1.00 H +ATOM 1223 H61 A A 38 -1.778 -22.306 1.113 1.00 1.00 H +ATOM 1224 H62 A A 38 -0.294 -22.894 0.396 1.00 1.00 H +ATOM 1225 H2 A A 38 -0.908 -21.641 5.461 1.00 1.00 H +ATOM 1226 P G A 39 3.982 -27.463 7.242 1.00 1.00 P +ATOM 1227 OP1 G A 39 4.801 -28.067 8.318 1.00 1.00 O +ATOM 1228 OP2 G A 39 3.606 -28.272 6.062 1.00 1.00 O +ATOM 1229 O5' G A 39 2.634 -26.876 7.903 1.00 1.00 O +ATOM 1230 C5' G A 39 2.667 -26.260 9.194 1.00 1.00 C +ATOM 1231 C4' G A 39 1.479 -25.323 9.407 1.00 1.00 C +ATOM 1232 O4' G A 39 1.295 -24.515 8.238 1.00 1.00 O +ATOM 1233 C3' G A 39 0.157 -26.037 9.677 1.00 1.00 C +ATOM 1234 O3' G A 39 -0.099 -26.054 11.087 1.00 1.00 O +ATOM 1235 C2' G A 39 -0.873 -25.167 8.977 1.00 1.00 C +ATOM 1236 O2' G A 39 -1.397 -24.165 9.856 1.00 1.00 O +ATOM 1237 C1' G A 39 -0.080 -24.546 7.839 1.00 1.00 C +ATOM 1238 N9 G A 39 -0.160 -25.302 6.574 1.00 1.00 N +ATOM 1239 C8 G A 39 0.705 -26.247 6.085 1.00 1.00 C +ATOM 1240 N7 G A 39 0.357 -26.735 4.927 1.00 1.00 N +ATOM 1241 C5 G A 39 -0.825 -26.064 4.624 1.00 1.00 C +ATOM 1242 C6 G A 39 -1.669 -26.176 3.484 1.00 1.00 C +ATOM 1243 O6 G A 39 -1.534 -26.904 2.503 1.00 1.00 O +ATOM 1244 N1 G A 39 -2.758 -25.321 3.573 1.00 1.00 N +ATOM 1245 C2 G A 39 -3.009 -24.465 4.624 1.00 1.00 C +ATOM 1246 N2 G A 39 -4.109 -23.719 4.527 1.00 1.00 N +ATOM 1247 N3 G A 39 -2.217 -24.358 5.695 1.00 1.00 N +ATOM 1248 C4 G A 39 -1.148 -25.185 5.627 1.00 1.00 C +ATOM 1249 H5' G A 39 3.591 -25.690 9.292 1.00 1.00 H +ATOM 1250 H5'' G A 39 2.647 -27.037 9.958 1.00 1.00 H +ATOM 1251 H4' G A 39 1.698 -24.665 10.245 1.00 1.00 H +ATOM 1252 H3' G A 39 0.165 -27.046 9.261 1.00 1.00 H +ATOM 1253 H2' G A 39 -1.674 -25.787 8.576 1.00 1.00 H +ATOM 1254 HO2' G A 39 -2.271 -23.931 9.533 1.00 1.00 H +ATOM 1255 H1' G A 39 -0.429 -23.529 7.669 1.00 1.00 H +ATOM 1256 H8 G A 39 1.605 -26.561 6.616 1.00 1.00 H +ATOM 1257 H1 G A 39 -3.405 -25.344 2.798 1.00 1.00 H +ATOM 1258 H21 G A 39 -4.706 -23.802 3.716 1.00 1.00 H +ATOM 1259 H22 G A 39 -4.348 -23.072 5.265 1.00 1.00 H +ATOM 1260 P U A 40 -0.847 -27.305 11.779 1.00 1.00 P +ATOM 1261 OP1 U A 40 -0.869 -27.077 13.241 1.00 1.00 O +ATOM 1262 OP2 U A 40 -0.259 -28.550 11.237 1.00 1.00 O +ATOM 1263 O5' U A 40 -2.356 -27.176 11.228 1.00 1.00 O +ATOM 1264 C5' U A 40 -3.247 -26.194 11.767 1.00 1.00 C +ATOM 1265 C4' U A 40 -4.609 -26.228 11.077 1.00 1.00 C +ATOM 1266 O4' U A 40 -4.452 -25.885 9.697 1.00 1.00 O +ATOM 1267 C3' U A 40 -5.304 -27.585 11.125 1.00 1.00 C +ATOM 1268 O3' U A 40 -6.220 -27.623 12.227 1.00 1.00 O +ATOM 1269 C2' U A 40 -6.077 -27.630 9.816 1.00 1.00 C +ATOM 1270 O2' U A 40 -7.391 -27.083 9.967 1.00 1.00 O +ATOM 1271 C1' U A 40 -5.226 -26.778 8.883 1.00 1.00 C +ATOM 1272 N1 U A 40 -4.279 -27.561 8.059 1.00 1.00 N +ATOM 1273 C2 U A 40 -4.671 -27.895 6.776 1.00 1.00 C +ATOM 1274 O2 U A 40 -5.766 -27.572 6.321 1.00 1.00 O +ATOM 1275 N3 U A 40 -3.756 -28.619 6.031 1.00 1.00 N +ATOM 1276 C4 U A 40 -2.503 -29.030 6.453 1.00 1.00 C +ATOM 1277 O4 U A 40 -1.770 -29.671 5.703 1.00 1.00 O +ATOM 1278 C5 U A 40 -2.179 -28.636 7.806 1.00 1.00 C +ATOM 1279 C6 U A 40 -3.058 -27.927 8.554 1.00 1.00 C +ATOM 1280 H5' U A 40 -2.806 -25.206 11.635 1.00 1.00 H +ATOM 1281 H5'' U A 40 -3.381 -26.384 12.832 1.00 1.00 H +ATOM 1282 H4' U A 40 -5.256 -25.486 11.542 1.00 1.00 H +ATOM 1283 H3' U A 40 -4.576 -28.396 11.179 1.00 1.00 H +ATOM 1284 H2' U A 40 -6.126 -28.655 9.445 1.00 1.00 H +ATOM 1285 HO2' U A 40 -7.579 -27.050 10.907 1.00 1.00 H +ATOM 1286 H1' U A 40 -5.878 -26.195 8.232 1.00 1.00 H +ATOM 1287 H3 U A 40 -4.029 -28.869 5.092 1.00 1.00 H +ATOM 1288 H5 U A 40 -1.213 -28.913 8.228 1.00 1.00 H +ATOM 1289 H6 U A 40 -2.787 -27.643 9.570 1.00 1.00 H +ATOM 1290 P C A 41 -6.257 -28.886 13.229 1.00 1.00 P +ATOM 1291 OP1 C A 41 -7.217 -28.582 14.315 1.00 1.00 O +ATOM 1292 OP2 C A 41 -4.863 -29.255 13.559 1.00 1.00 O +ATOM 1293 O5' C A 41 -6.888 -30.058 12.321 1.00 1.00 O +ATOM 1294 C5' C A 41 -8.274 -30.033 11.964 1.00 1.00 C +ATOM 1295 C4' C A 41 -8.587 -31.021 10.843 1.00 1.00 C +ATOM 1296 O4' C A 41 -7.890 -30.645 9.661 1.00 1.00 O +ATOM 1297 C3' C A 41 -8.189 -32.461 11.130 1.00 1.00 C +ATOM 1298 O3' C A 41 -9.276 -33.155 11.756 1.00 1.00 O +ATOM 1299 C2' C A 41 -7.941 -33.041 9.748 1.00 1.00 C +ATOM 1300 O2' C A 41 -9.092 -33.746 9.266 1.00 1.00 O +ATOM 1301 C1' C A 41 -7.630 -31.820 8.882 1.00 1.00 C +ATOM 1302 N1 C A 41 -6.228 -31.759 8.415 1.00 1.00 N +ATOM 1303 C2 C A 41 -5.950 -32.329 7.182 1.00 1.00 C +ATOM 1304 O2 C A 41 -6.849 -32.859 6.532 1.00 1.00 O +ATOM 1305 N3 C A 41 -4.668 -32.283 6.724 1.00 1.00 N +ATOM 1306 C4 C A 41 -3.700 -31.701 7.445 1.00 1.00 C +ATOM 1307 N4 C A 41 -2.456 -31.674 6.968 1.00 1.00 N +ATOM 1308 C5 C A 41 -3.983 -31.113 8.717 1.00 1.00 C +ATOM 1309 C6 C A 41 -5.254 -31.163 9.162 1.00 1.00 C +ATOM 1310 H5' C A 41 -8.538 -29.028 11.634 1.00 1.00 H +ATOM 1311 H5'' C A 41 -8.870 -30.289 12.838 1.00 1.00 H +ATOM 1312 H4' C A 41 -9.654 -30.987 10.633 1.00 1.00 H +ATOM 1313 H3' C A 41 -7.284 -32.501 11.740 1.00 1.00 H +ATOM 1314 H2' C A 41 -7.072 -33.700 9.778 1.00 1.00 H +ATOM 1315 HO2' C A 41 -9.066 -33.716 8.308 1.00 1.00 H +ATOM 1316 H1' C A 41 -8.292 -31.818 8.015 1.00 1.00 H +ATOM 1317 H41 C A 41 -2.250 -32.088 6.071 1.00 1.00 H +ATOM 1318 H42 C A 41 -1.718 -31.239 7.504 1.00 1.00 H +ATOM 1319 H5 C A 41 -3.197 -30.640 9.307 1.00 1.00 H +ATOM 1320 H6 C A 41 -5.505 -30.725 10.127 1.00 1.00 H +ATOM 1321 P C A 42 -9.048 -34.608 12.417 1.00 1.00 P +ATOM 1322 OP1 C A 42 -10.046 -34.786 13.495 1.00 1.00 O +ATOM 1323 OP2 C A 42 -7.607 -34.761 12.713 1.00 1.00 O +ATOM 1324 O5' C A 42 -9.424 -35.613 11.211 1.00 1.00 O +ATOM 1325 C5' C A 42 -10.769 -35.702 10.727 1.00 1.00 C +ATOM 1326 C4' C A 42 -10.845 -36.439 9.388 1.00 1.00 C +ATOM 1327 O4' C A 42 -9.988 -35.803 8.437 1.00 1.00 O +ATOM 1328 C3' C A 42 -10.424 -37.902 9.444 1.00 1.00 C +ATOM 1329 O3' C A 42 -11.569 -38.732 9.667 1.00 1.00 O +ATOM 1330 C2' C A 42 -9.872 -38.163 8.055 1.00 1.00 C +ATOM 1331 O2' C A 42 -10.893 -38.620 7.163 1.00 1.00 O +ATOM 1332 C1' C A 42 -9.335 -36.800 7.634 1.00 1.00 C +ATOM 1333 N1 C A 42 -7.882 -36.649 7.833 1.00 1.00 N +ATOM 1334 C2 C A 42 -7.047 -37.045 6.801 1.00 1.00 C +ATOM 1335 O2 C A 42 -7.523 -37.516 5.771 1.00 1.00 O +ATOM 1336 N3 C A 42 -5.702 -36.901 6.966 1.00 1.00 N +ATOM 1337 C4 C A 42 -5.199 -36.390 8.097 1.00 1.00 C +ATOM 1338 N4 C A 42 -3.879 -36.261 8.225 1.00 1.00 N +ATOM 1339 C5 C A 42 -6.058 -35.980 9.166 1.00 1.00 C +ATOM 1340 C6 C A 42 -7.387 -36.126 8.993 1.00 1.00 C +ATOM 1341 H5' C A 42 -11.168 -34.696 10.601 1.00 1.00 H +ATOM 1342 H5'' C A 42 -11.374 -36.235 11.460 1.00 1.00 H +ATOM 1343 H4' C A 42 -11.867 -36.384 9.018 1.00 1.00 H +ATOM 1344 H3' C A 42 -9.659 -38.061 10.207 1.00 1.00 H +ATOM 1345 H2' C A 42 -9.055 -38.882 8.107 1.00 1.00 H +ATOM 1346 HO2' C A 42 -11.726 -38.577 7.640 1.00 1.00 H +ATOM 1347 H1' C A 42 -9.574 -36.628 6.585 1.00 1.00 H +ATOM 1348 H41 C A 42 -3.269 -36.547 7.475 1.00 1.00 H +ATOM 1349 H42 C A 42 -3.489 -35.877 9.074 1.00 1.00 H +ATOM 1350 H5 C A 42 -5.651 -35.563 10.088 1.00 1.00 H +ATOM 1351 H6 C A 42 -8.070 -35.828 9.787 1.00 1.00 H +ATOM 1352 P U A 43 -11.409 -40.193 10.326 1.00 1.00 P +ATOM 1353 OP1 U A 43 -12.722 -40.872 10.267 1.00 1.00 O +ATOM 1354 OP2 U A 43 -10.714 -40.043 11.624 1.00 1.00 O +ATOM 1355 O5' U A 43 -10.411 -40.942 9.303 1.00 1.00 O +ATOM 1356 C5' U A 43 -10.832 -41.248 7.970 1.00 1.00 C +ATOM 1357 C4' U A 43 -9.688 -41.810 7.126 1.00 1.00 C +ATOM 1358 O4' U A 43 -8.603 -40.893 7.106 1.00 1.00 O +ATOM 1359 C3' U A 43 -9.127 -43.131 7.637 1.00 1.00 C +ATOM 1360 O3' U A 43 -9.764 -44.244 6.999 1.00 1.00 O +ATOM 1361 C2' U A 43 -7.640 -43.068 7.279 1.00 1.00 C +ATOM 1362 O2' U A 43 -7.323 -43.984 6.224 1.00 1.00 O +ATOM 1363 C1' U A 43 -7.405 -41.625 6.842 1.00 1.00 C +ATOM 1364 N1 U A 43 -6.299 -40.961 7.560 1.00 1.00 N +ATOM 1365 C2 U A 43 -5.033 -41.066 7.015 1.00 1.00 C +ATOM 1366 O2 U A 43 -4.816 -41.689 5.977 1.00 1.00 O +ATOM 1367 N3 U A 43 -4.018 -40.428 7.706 1.00 1.00 N +ATOM 1368 C4 U A 43 -4.159 -39.706 8.879 1.00 1.00 C +ATOM 1369 O4 U A 43 -3.185 -39.175 9.408 1.00 1.00 O +ATOM 1370 C5 U A 43 -5.516 -39.651 9.376 1.00 1.00 C +ATOM 1371 C6 U A 43 -6.526 -40.267 8.716 1.00 1.00 C +ATOM 1372 H5' U A 43 -11.207 -40.340 7.499 1.00 1.00 H +ATOM 1373 H5'' U A 43 -11.636 -41.983 8.012 1.00 1.00 H +ATOM 1374 H4' U A 43 -10.039 -41.949 6.105 1.00 1.00 H +ATOM 1375 H3' U A 43 -9.246 -43.190 8.722 1.00 1.00 H +ATOM 1376 HO3' U A 43 -9.758 -44.973 7.623 1.00 1.00 H +ATOM 1377 H2' U A 43 -7.036 -43.281 8.162 1.00 1.00 H +ATOM 1378 HO2' U A 43 -7.010 -43.465 5.479 1.00 1.00 H +ATOM 1379 H1' U A 43 -7.203 -41.602 5.771 1.00 1.00 H +ATOM 1380 H3 U A 43 -3.087 -40.496 7.319 1.00 1.00 H +ATOM 1381 H5 U A 43 -5.730 -39.105 10.296 1.00 1.00 H +ATOM 1382 H6 U A 43 -7.538 -40.209 9.113 1.00 1.00 H +TER 1383 U A 43 +ATOM 1384 O5' G B 44 -4.063 39.188 14.186 1.00 1.00 O +ATOM 1385 C5' G B 44 -4.969 40.168 13.670 1.00 1.00 C +ATOM 1386 C4' G B 44 -4.300 41.038 12.608 1.00 1.00 C +ATOM 1387 O4' G B 44 -3.434 41.989 13.240 1.00 1.00 O +ATOM 1388 C3' G B 44 -3.464 40.247 11.604 1.00 1.00 C +ATOM 1389 O3' G B 44 -4.176 40.128 10.369 1.00 1.00 O +ATOM 1390 C2' G B 44 -2.224 41.101 11.397 1.00 1.00 C +ATOM 1391 O2' G B 44 -2.380 41.994 10.288 1.00 1.00 O +ATOM 1392 C1' G B 44 -2.113 41.861 12.709 1.00 1.00 C +ATOM 1393 N9 G B 44 -1.293 41.179 13.726 1.00 1.00 N +ATOM 1394 C8 G B 44 -1.696 40.603 14.903 1.00 1.00 C +ATOM 1395 N7 G B 44 -0.727 40.064 15.586 1.00 1.00 N +ATOM 1396 C5 G B 44 0.403 40.301 14.811 1.00 1.00 C +ATOM 1397 C6 G B 44 1.760 39.942 15.044 1.00 1.00 C +ATOM 1398 O6 G B 44 2.234 39.334 16.002 1.00 1.00 O +ATOM 1399 N1 G B 44 2.585 40.370 14.013 1.00 1.00 N +ATOM 1400 C2 G B 44 2.163 41.056 12.894 1.00 1.00 C +ATOM 1401 N2 G B 44 3.107 41.382 12.011 1.00 1.00 N +ATOM 1402 N3 G B 44 0.887 41.394 12.671 1.00 1.00 N +ATOM 1403 C4 G B 44 0.067 40.984 13.668 1.00 1.00 C +ATOM 1404 H5' G B 44 -5.317 40.795 14.493 1.00 1.00 H +ATOM 1405 H5'' G B 44 -5.824 39.665 13.225 1.00 1.00 H +ATOM 1406 H4' G B 44 -5.072 41.583 12.067 1.00 1.00 H +ATOM 1407 H3' G B 44 -3.199 39.267 12.005 1.00 1.00 H +ATOM 1408 H2' G B 44 -1.348 40.464 11.262 1.00 1.00 H +ATOM 1409 HO2' G B 44 -3.276 42.337 10.322 1.00 1.00 H +ATOM 1410 H1' G B 44 -1.700 42.851 12.521 1.00 1.00 H +ATOM 1411 H8 G B 44 -2.734 40.597 15.237 1.00 1.00 H +ATOM 1412 H1 G B 44 3.566 40.151 14.109 1.00 1.00 H +ATOM 1413 H21 G B 44 4.068 41.126 12.183 1.00 1.00 H +ATOM 1414 H22 G B 44 2.860 41.886 11.171 1.00 1.00 H +ATOM 1415 HO5' G B 44 -4.048 39.288 15.141 1.00 1.00 H +ATOM 1416 P G B 45 -4.009 38.812 9.457 1.00 1.00 P +ATOM 1417 OP1 G B 45 -4.719 39.042 8.178 1.00 1.00 O +ATOM 1418 OP2 G B 45 -4.340 37.630 10.283 1.00 1.00 O +ATOM 1419 O5' G B 45 -2.429 38.791 9.158 1.00 1.00 O +ATOM 1420 C5' G B 45 -1.822 39.819 8.370 1.00 1.00 C +ATOM 1421 C4' G B 45 -0.314 39.616 8.260 1.00 1.00 C +ATOM 1422 O4' G B 45 0.302 39.798 9.531 1.00 1.00 O +ATOM 1423 C3' G B 45 0.098 38.237 7.775 1.00 1.00 C +ATOM 1424 O3' G B 45 0.187 38.233 6.345 1.00 1.00 O +ATOM 1425 C2' G B 45 1.477 38.044 8.387 1.00 1.00 C +ATOM 1426 O2' G B 45 2.513 38.370 7.455 1.00 1.00 O +ATOM 1427 C1' G B 45 1.484 38.986 9.588 1.00 1.00 C +ATOM 1428 N9 G B 45 1.499 38.286 10.877 1.00 1.00 N +ATOM 1429 C8 G B 45 0.464 38.045 11.746 1.00 1.00 C +ATOM 1430 N7 G B 45 0.821 37.414 12.830 1.00 1.00 N +ATOM 1431 C5 G B 45 2.190 37.223 12.671 1.00 1.00 C +ATOM 1432 C6 G B 45 3.128 36.589 13.533 1.00 1.00 C +ATOM 1433 O6 G B 45 2.926 36.063 14.626 1.00 1.00 O +ATOM 1434 N1 G B 45 4.408 36.609 12.995 1.00 1.00 N +ATOM 1435 C2 G B 45 4.747 37.168 11.781 1.00 1.00 C +ATOM 1436 N2 G B 45 6.031 37.091 11.433 1.00 1.00 N +ATOM 1437 N3 G B 45 3.868 37.764 10.970 1.00 1.00 N +ATOM 1438 C4 G B 45 2.613 37.753 11.478 1.00 1.00 C +ATOM 1439 H5' G B 45 -2.017 40.786 8.834 1.00 1.00 H +ATOM 1440 H5'' G B 45 -2.256 39.806 7.372 1.00 1.00 H +ATOM 1441 H4' G B 45 0.088 40.362 7.576 1.00 1.00 H +ATOM 1442 H3' G B 45 -0.596 37.476 8.135 1.00 1.00 H +ATOM 1443 H2' G B 45 1.583 37.019 8.737 1.00 1.00 H +ATOM 1444 HO2' G B 45 2.972 37.553 7.245 1.00 1.00 H +ATOM 1445 H1' G B 45 2.361 39.630 9.533 1.00 1.00 H +ATOM 1446 H8 G B 45 -0.563 38.350 11.546 1.00 1.00 H +ATOM 1447 H1 G B 45 5.132 36.177 13.552 1.00 1.00 H +ATOM 1448 H21 G B 45 6.695 36.640 12.046 1.00 1.00 H +ATOM 1449 H22 G B 45 6.339 37.482 10.555 1.00 1.00 H +ATOM 1450 P G B 46 0.057 36.857 5.515 1.00 1.00 P +ATOM 1451 OP1 G B 46 -0.366 37.189 4.137 1.00 1.00 O +ATOM 1452 OP2 G B 46 -0.734 35.903 6.322 1.00 1.00 O +ATOM 1453 O5' G B 46 1.580 36.331 5.461 1.00 1.00 O +ATOM 1454 C5' G B 46 2.586 37.080 4.774 1.00 1.00 C +ATOM 1455 C4' G B 46 3.988 36.585 5.120 1.00 1.00 C +ATOM 1456 O4' G B 46 4.155 36.566 6.538 1.00 1.00 O +ATOM 1457 C3' G B 46 4.297 35.181 4.619 1.00 1.00 C +ATOM 1458 O3' G B 46 4.919 35.262 3.329 1.00 1.00 O +ATOM 1459 C2' G B 46 5.283 34.649 5.648 1.00 1.00 C +ATOM 1460 O2' G B 46 6.636 34.907 5.259 1.00 1.00 O +ATOM 1461 C1' G B 46 4.914 35.409 6.919 1.00 1.00 C +ATOM 1462 N9 G B 46 4.091 34.627 7.857 1.00 1.00 N +ATOM 1463 C8 G B 46 2.734 34.661 8.046 1.00 1.00 C +ATOM 1464 N7 G B 46 2.312 33.868 8.990 1.00 1.00 N +ATOM 1465 C5 G B 46 3.473 33.262 9.463 1.00 1.00 C +ATOM 1466 C6 G B 46 3.642 32.298 10.496 1.00 1.00 C +ATOM 1467 O6 G B 46 2.783 31.782 11.209 1.00 1.00 O +ATOM 1468 N1 G B 46 4.977 31.951 10.654 1.00 1.00 N +ATOM 1469 C2 G B 46 6.021 32.465 9.913 1.00 1.00 C +ATOM 1470 N2 G B 46 7.236 32.008 10.210 1.00 1.00 N +ATOM 1471 N3 G B 46 5.864 33.371 8.943 1.00 1.00 N +ATOM 1472 C4 G B 46 4.568 33.721 8.775 1.00 1.00 C +ATOM 1473 H5' G B 46 2.500 38.130 5.053 1.00 1.00 H +ATOM 1474 H5'' G B 46 2.428 36.983 3.699 1.00 1.00 H +ATOM 1475 H4' G B 46 4.717 37.274 4.699 1.00 1.00 H +ATOM 1476 H3' G B 46 3.392 34.569 4.590 1.00 1.00 H +ATOM 1477 H2' G B 46 5.122 33.581 5.801 1.00 1.00 H +ATOM 1478 HO2' G B 46 6.610 35.332 4.400 1.00 1.00 H +ATOM 1479 H1' G B 46 5.823 35.727 7.432 1.00 1.00 H +ATOM 1480 H8 G B 46 2.068 35.294 7.460 1.00 1.00 H +ATOM 1481 H1 G B 46 5.179 31.269 11.370 1.00 1.00 H +ATOM 1482 H21 G B 46 7.353 31.322 10.945 1.00 1.00 H +ATOM 1483 H22 G B 46 8.042 32.345 9.701 1.00 1.00 H +ATOM 1484 P A B 47 4.739 34.079 2.246 1.00 1.00 P +ATOM 1485 OP1 A B 47 5.311 34.541 0.961 1.00 1.00 O +ATOM 1486 OP2 A B 47 3.336 33.613 2.302 1.00 1.00 O +ATOM 1487 O5' A B 47 5.682 32.907 2.821 1.00 1.00 O +ATOM 1488 C5' A B 47 7.106 33.034 2.788 1.00 1.00 C +ATOM 1489 C4' A B 47 7.784 31.860 3.487 1.00 1.00 C +ATOM 1490 O4' A B 47 7.487 31.892 4.874 1.00 1.00 O +ATOM 1491 C3' A B 47 7.348 30.497 2.983 1.00 1.00 C +ATOM 1492 O3' A B 47 8.205 30.085 1.913 1.00 1.00 O +ATOM 1493 C2' A B 47 7.546 29.595 4.194 1.00 1.00 C +ATOM 1494 O2' A B 47 8.840 28.981 4.180 1.00 1.00 O +ATOM 1495 C1' A B 47 7.395 30.552 5.381 1.00 1.00 C +ATOM 1496 N9 A B 47 6.100 30.448 6.075 1.00 1.00 N +ATOM 1497 C8 A B 47 4.892 30.990 5.717 1.00 1.00 C +ATOM 1498 N7 A B 47 3.923 30.715 6.548 1.00 1.00 N +ATOM 1499 C5 A B 47 4.534 29.935 7.525 1.00 1.00 C +ATOM 1500 C6 A B 47 4.047 29.322 8.690 1.00 1.00 C +ATOM 1501 N6 A B 47 2.774 29.405 9.081 1.00 1.00 N +ATOM 1502 N1 A B 47 4.922 28.623 9.432 1.00 1.00 N +ATOM 1503 C2 A B 47 6.188 28.544 9.037 1.00 1.00 C +ATOM 1504 N3 A B 47 6.765 29.073 7.968 1.00 1.00 N +ATOM 1505 C4 A B 47 5.861 29.768 7.245 1.00 1.00 C +ATOM 1506 H5' A B 47 7.393 33.960 3.287 1.00 1.00 H +ATOM 1507 H5'' A B 47 7.436 33.071 1.750 1.00 1.00 H +ATOM 1508 H4' A B 47 8.862 31.952 3.366 1.00 1.00 H +ATOM 1509 H3' A B 47 6.301 30.513 2.674 1.00 1.00 H +ATOM 1510 H2' A B 47 6.759 28.838 4.225 1.00 1.00 H +ATOM 1511 HO2' A B 47 9.302 29.269 4.969 1.00 1.00 H +ATOM 1512 H1' A B 47 8.200 30.376 6.095 1.00 1.00 H +ATOM 1513 H8 A B 47 4.751 31.594 4.820 1.00 1.00 H +ATOM 1514 H61 A B 47 2.474 28.947 9.926 1.00 1.00 H +ATOM 1515 H62 A B 47 2.110 29.929 8.529 1.00 1.00 H +ATOM 1516 H2 A B 47 6.845 27.962 9.684 1.00 1.00 H +ATOM 1517 P U B 48 7.631 29.225 0.678 1.00 1.00 P +ATOM 1518 OP1 U B 48 8.739 28.992 -0.276 1.00 1.00 O +ATOM 1519 OP2 U B 48 6.379 29.862 0.211 1.00 1.00 O +ATOM 1520 O5' U B 48 7.254 27.817 1.362 1.00 1.00 O +ATOM 1521 C5' U B 48 8.269 26.997 1.946 1.00 1.00 C +ATOM 1522 C4' U B 48 7.673 25.970 2.905 1.00 1.00 C +ATOM 1523 O4' U B 48 7.005 26.640 3.965 1.00 1.00 O +ATOM 1524 C3' U B 48 6.651 25.042 2.271 1.00 1.00 C +ATOM 1525 O3' U B 48 7.312 23.858 1.808 1.00 1.00 O +ATOM 1526 C2' U B 48 5.713 24.694 3.421 1.00 1.00 C +ATOM 1527 O2' U B 48 6.052 23.429 4.001 1.00 1.00 O +ATOM 1528 C1' U B 48 5.907 25.841 4.423 1.00 1.00 C +ATOM 1529 N1 U B 48 4.732 26.732 4.554 1.00 1.00 N +ATOM 1530 C2 U B 48 3.880 26.513 5.617 1.00 1.00 C +ATOM 1531 O2 U B 48 4.077 25.619 6.438 1.00 1.00 O +ATOM 1532 N3 U B 48 2.789 27.358 5.708 1.00 1.00 N +ATOM 1533 C4 U B 48 2.482 28.390 4.837 1.00 1.00 C +ATOM 1534 O4 U B 48 1.482 29.083 5.015 1.00 1.00 O +ATOM 1535 C5 U B 48 3.426 28.547 3.754 1.00 1.00 C +ATOM 1536 C6 U B 48 4.502 27.730 3.645 1.00 1.00 C +ATOM 1537 H5' U B 48 8.969 27.630 2.493 1.00 1.00 H +ATOM 1538 H5'' U B 48 8.806 26.475 1.154 1.00 1.00 H +ATOM 1539 H4' U B 48 8.478 25.373 3.330 1.00 1.00 H +ATOM 1540 H3' U B 48 6.116 25.543 1.463 1.00 1.00 H +ATOM 1541 H2' U B 48 4.681 24.686 3.064 1.00 1.00 H +ATOM 1542 HO2' U B 48 5.284 22.861 3.915 1.00 1.00 H +ATOM 1543 H1' U B 48 6.156 25.424 5.400 1.00 1.00 H +ATOM 1544 H3 U B 48 2.158 27.209 6.482 1.00 1.00 H +ATOM 1545 H5 U B 48 3.270 29.333 3.015 1.00 1.00 H +ATOM 1546 H6 U B 48 5.199 27.871 2.818 1.00 1.00 H +ATOM 1547 P A B 49 7.110 23.338 0.299 1.00 1.00 P +ATOM 1548 OP1 A B 49 7.116 24.513 -0.601 1.00 1.00 O +ATOM 1549 OP2 A B 49 5.965 22.399 0.282 1.00 1.00 O +ATOM 1550 O5' A B 49 8.458 22.495 0.038 1.00 1.00 O +ATOM 1551 C5' A B 49 8.445 21.065 0.086 1.00 1.00 C +ATOM 1552 C4' A B 49 8.492 20.550 1.523 1.00 1.00 C +ATOM 1553 O4' A B 49 7.306 20.959 2.208 1.00 1.00 O +ATOM 1554 C3' A B 49 8.603 19.029 1.634 1.00 1.00 C +ATOM 1555 O3' A B 49 9.634 18.691 2.570 1.00 1.00 O +ATOM 1556 C2' A B 49 7.255 18.575 2.178 1.00 1.00 C +ATOM 1557 O2' A B 49 7.411 17.528 3.142 1.00 1.00 O +ATOM 1558 C1' A B 49 6.676 19.829 2.814 1.00 1.00 C +ATOM 1559 N9 A B 49 5.222 19.977 2.627 1.00 1.00 N +ATOM 1560 C8 A B 49 4.523 20.248 1.480 1.00 1.00 C +ATOM 1561 N7 A B 49 3.233 20.338 1.657 1.00 1.00 N +ATOM 1562 C5 A B 49 3.069 20.109 3.020 1.00 1.00 C +ATOM 1563 C6 A B 49 1.932 20.067 3.846 1.00 1.00 C +ATOM 1564 N6 A B 49 0.693 20.266 3.396 1.00 1.00 N +ATOM 1565 N1 A B 49 2.130 19.814 5.151 1.00 1.00 N +ATOM 1566 C2 A B 49 3.365 19.617 5.594 1.00 1.00 C +ATOM 1567 N3 A B 49 4.506 19.631 4.922 1.00 1.00 N +ATOM 1568 C4 A B 49 4.275 19.888 3.618 1.00 1.00 C +ATOM 1569 H5' A B 49 9.308 20.683 -0.457 1.00 1.00 H +ATOM 1570 H5'' A B 49 7.535 20.703 -0.391 1.00 1.00 H +ATOM 1571 H4' A B 49 9.348 21.000 2.026 1.00 1.00 H +ATOM 1572 H3' A B 49 8.796 18.581 0.659 1.00 1.00 H +ATOM 1573 H2' A B 49 6.616 18.247 1.355 1.00 1.00 H +ATOM 1574 HO2' A B 49 6.630 17.537 3.701 1.00 1.00 H +ATOM 1575 H1' A B 49 6.897 19.826 3.880 1.00 1.00 H +ATOM 1576 H8 A B 49 5.000 20.375 0.508 1.00 1.00 H +ATOM 1577 H61 A B 49 -0.086 20.224 4.036 1.00 1.00 H +ATOM 1578 H62 A B 49 0.530 20.456 2.415 1.00 1.00 H +ATOM 1579 H2 A B 49 3.453 19.415 6.662 1.00 1.00 H +ATOM 1580 P U B 50 10.020 17.151 2.838 1.00 1.00 P +ATOM 1581 OP1 U B 50 11.493 17.054 2.942 1.00 1.00 O +ATOM 1582 OP2 U B 50 9.293 16.314 1.856 1.00 1.00 O +ATOM 1583 O5' U B 50 9.391 16.875 4.296 1.00 1.00 O +ATOM 1584 C5' U B 50 10.238 16.793 5.448 1.00 1.00 C +ATOM 1585 C4' U B 50 9.443 16.955 6.744 1.00 1.00 C +ATOM 1586 O4' U B 50 9.407 18.340 7.100 1.00 1.00 O +ATOM 1587 C3' U B 50 7.997 16.459 6.649 1.00 1.00 C +ATOM 1588 O3' U B 50 7.682 15.643 7.780 1.00 1.00 O +ATOM 1589 C2' U B 50 7.155 17.723 6.694 1.00 1.00 C +ATOM 1590 O2' U B 50 5.951 17.531 7.443 1.00 1.00 O +ATOM 1591 C1' U B 50 8.061 18.734 7.373 1.00 1.00 C +ATOM 1592 N1 U B 50 7.884 20.122 6.894 1.00 1.00 N +ATOM 1593 C2 U B 50 8.984 20.956 6.951 1.00 1.00 C +ATOM 1594 O2 U B 50 10.072 20.573 7.377 1.00 1.00 O +ATOM 1595 N3 U B 50 8.790 22.250 6.504 1.00 1.00 N +ATOM 1596 C4 U B 50 7.608 22.775 6.011 1.00 1.00 C +ATOM 1597 O4 U B 50 7.550 23.945 5.638 1.00 1.00 O +ATOM 1598 C5 U B 50 6.511 21.834 5.988 1.00 1.00 C +ATOM 1599 C6 U B 50 6.676 20.561 6.421 1.00 1.00 C +ATOM 1600 H5' U B 50 10.990 17.579 5.393 1.00 1.00 H +ATOM 1601 H5'' U B 50 10.736 15.823 5.455 1.00 1.00 H +ATOM 1602 H4' U B 50 9.950 16.408 7.537 1.00 1.00 H +ATOM 1603 H3' U B 50 7.833 15.918 5.716 1.00 1.00 H +ATOM 1604 H2' U B 50 6.929 18.048 5.676 1.00 1.00 H +ATOM 1605 HO2' U B 50 5.378 16.965 6.921 1.00 1.00 H +ATOM 1606 H1' U B 50 7.890 18.704 8.448 1.00 1.00 H +ATOM 1607 H3 U B 50 9.586 22.870 6.540 1.00 1.00 H +ATOM 1608 H5 U B 50 5.537 22.153 5.616 1.00 1.00 H +ATOM 1609 H6 U B 50 5.831 19.873 6.393 1.00 1.00 H +ATOM 1610 P G B 51 6.484 14.571 7.686 1.00 1.00 P +ATOM 1611 OP1 G B 51 6.044 14.241 9.060 1.00 1.00 O +ATOM 1612 OP2 G B 51 6.902 13.491 6.763 1.00 1.00 O +ATOM 1613 O5' G B 51 5.316 15.418 6.970 1.00 1.00 O +ATOM 1614 C5' G B 51 3.968 15.358 7.444 1.00 1.00 C +ATOM 1615 C4' G B 51 3.094 14.561 6.489 1.00 1.00 C +ATOM 1616 O4' G B 51 2.468 15.446 5.560 1.00 1.00 O +ATOM 1617 C3' G B 51 3.879 13.544 5.681 1.00 1.00 C +ATOM 1618 O3' G B 51 3.775 12.255 6.286 1.00 1.00 O +ATOM 1619 C2' G B 51 3.197 13.526 4.324 1.00 1.00 C +ATOM 1620 O2' G B 51 2.294 12.422 4.209 1.00 1.00 O +ATOM 1621 C1' G B 51 2.460 14.854 4.252 1.00 1.00 C +ATOM 1622 N9 G B 51 3.075 15.814 3.318 1.00 1.00 N +ATOM 1623 C8 G B 51 4.099 16.697 3.550 1.00 1.00 C +ATOM 1624 N7 G B 51 4.414 17.425 2.517 1.00 1.00 N +ATOM 1625 C5 G B 51 3.536 16.998 1.526 1.00 1.00 C +ATOM 1626 C6 G B 51 3.406 17.431 0.177 1.00 1.00 C +ATOM 1627 O6 G B 51 4.052 18.293 -0.413 1.00 1.00 O +ATOM 1628 N1 G B 51 2.398 16.742 -0.484 1.00 1.00 N +ATOM 1629 C2 G B 51 1.612 15.758 0.078 1.00 1.00 C +ATOM 1630 N2 G B 51 0.695 15.212 -0.719 1.00 1.00 N +ATOM 1631 N3 G B 51 1.733 15.349 1.345 1.00 1.00 N +ATOM 1632 C4 G B 51 2.713 16.010 2.007 1.00 1.00 C +ATOM 1633 H5' G B 51 3.573 16.371 7.529 1.00 1.00 H +ATOM 1634 H5'' G B 51 3.954 14.883 8.426 1.00 1.00 H +ATOM 1635 H4' G B 51 2.320 14.046 7.056 1.00 1.00 H +ATOM 1636 H3' G B 51 4.922 13.849 5.583 1.00 1.00 H +ATOM 1637 H2' G B 51 3.954 13.490 3.543 1.00 1.00 H +ATOM 1638 HO2' G B 51 2.471 11.997 3.366 1.00 1.00 H +ATOM 1639 H1' G B 51 1.430 14.677 3.947 1.00 1.00 H +ATOM 1640 H8 G B 51 4.603 16.782 4.514 1.00 1.00 H +ATOM 1641 H1 G B 51 2.246 16.997 -1.449 1.00 1.00 H +ATOM 1642 H21 G B 51 0.610 15.527 -1.678 1.00 1.00 H +ATOM 1643 H22 G B 51 0.094 14.491 -0.380 1.00 1.00 H +ATOM 1644 P G B 52 4.601 11.018 5.676 1.00 1.00 P +ATOM 1645 OP1 G B 52 4.510 9.884 6.622 1.00 1.00 O +ATOM 1646 OP2 G B 52 5.924 11.517 5.243 1.00 1.00 O +ATOM 1647 O5' G B 52 3.748 10.649 4.363 1.00 1.00 O +ATOM 1648 C5' G B 52 4.367 10.632 3.076 1.00 1.00 C +ATOM 1649 C4' G B 52 3.328 10.632 1.960 1.00 1.00 C +ATOM 1650 O4' G B 52 2.963 11.977 1.639 1.00 1.00 O +ATOM 1651 C3' G B 52 3.806 9.986 0.671 1.00 1.00 C +ATOM 1652 O3' G B 52 3.447 8.599 0.670 1.00 1.00 O +ATOM 1653 C2' G B 52 3.024 10.726 -0.402 1.00 1.00 C +ATOM 1654 O2' G B 52 1.790 10.064 -0.698 1.00 1.00 O +ATOM 1655 C1' G B 52 2.787 12.098 0.220 1.00 1.00 C +ATOM 1656 N9 G B 52 3.717 13.140 -0.263 1.00 1.00 N +ATOM 1657 C8 G B 52 4.686 13.816 0.435 1.00 1.00 C +ATOM 1658 N7 G B 52 5.341 14.687 -0.282 1.00 1.00 N +ATOM 1659 C5 G B 52 4.765 14.584 -1.545 1.00 1.00 C +ATOM 1660 C6 G B 52 5.064 15.290 -2.743 1.00 1.00 C +ATOM 1661 O6 G B 52 5.914 16.159 -2.926 1.00 1.00 O +ATOM 1662 N1 G B 52 4.247 14.882 -3.791 1.00 1.00 N +ATOM 1663 C2 G B 52 3.266 13.919 -3.700 1.00 1.00 C +ATOM 1664 N2 G B 52 2.583 13.665 -4.816 1.00 1.00 N +ATOM 1665 N3 G B 52 2.984 13.256 -2.575 1.00 1.00 N +ATOM 1666 C4 G B 52 3.770 13.639 -1.542 1.00 1.00 C +ATOM 1667 H5' G B 52 4.983 9.738 2.988 1.00 1.00 H +ATOM 1668 H5'' G B 52 5.000 11.513 2.973 1.00 1.00 H +ATOM 1669 H4' G B 52 2.439 10.108 2.307 1.00 1.00 H +ATOM 1670 H3' G B 52 4.881 10.123 0.540 1.00 1.00 H +ATOM 1671 H2' G B 52 3.630 10.831 -1.300 1.00 1.00 H +ATOM 1672 HO2' G B 52 1.079 10.643 -0.418 1.00 1.00 H +ATOM 1673 H1' G B 52 1.764 12.413 0.011 1.00 1.00 H +ATOM 1674 H8 G B 52 4.890 13.641 1.491 1.00 1.00 H +ATOM 1675 H1 G B 52 4.401 15.341 -4.678 1.00 1.00 H +ATOM 1676 H21 G B 52 2.799 14.167 -5.665 1.00 1.00 H +ATOM 1677 H22 G B 52 1.851 12.969 -4.813 1.00 1.00 H +ATOM 1678 P A B 53 4.430 7.498 0.025 1.00 1.00 P +ATOM 1679 OP1 A B 53 3.829 6.162 0.238 1.00 1.00 O +ATOM 1680 OP2 A B 53 5.805 7.772 0.495 1.00 1.00 O +ATOM 1681 O5' A B 53 4.359 7.834 -1.546 1.00 1.00 O +ATOM 1682 C5' A B 53 3.139 7.659 -2.269 1.00 1.00 C +ATOM 1683 C4' A B 53 3.217 8.284 -3.657 1.00 1.00 C +ATOM 1684 O4' A B 53 3.350 9.697 -3.553 1.00 1.00 O +ATOM 1685 C3' A B 53 4.392 7.816 -4.498 1.00 1.00 C +ATOM 1686 O3' A B 53 4.036 6.633 -5.224 1.00 1.00 O +ATOM 1687 C2' A B 53 4.607 8.971 -5.462 1.00 1.00 C +ATOM 1688 O2' A B 53 3.942 8.742 -6.708 1.00 1.00 O +ATOM 1689 C1' A B 53 4.021 10.175 -4.726 1.00 1.00 C +ATOM 1690 N9 A B 53 5.030 11.166 -4.311 1.00 1.00 N +ATOM 1691 C8 A B 53 5.748 11.245 -3.146 1.00 1.00 C +ATOM 1692 N7 A B 53 6.563 12.263 -3.096 1.00 1.00 N +ATOM 1693 C5 A B 53 6.370 12.903 -4.318 1.00 1.00 C +ATOM 1694 C6 A B 53 6.941 14.054 -4.887 1.00 1.00 C +ATOM 1695 N6 A B 53 7.861 14.796 -4.268 1.00 1.00 N +ATOM 1696 N1 A B 53 6.523 14.406 -6.114 1.00 1.00 N +ATOM 1697 C2 A B 53 5.607 13.663 -6.725 1.00 1.00 C +ATOM 1698 N3 A B 53 4.999 12.568 -6.297 1.00 1.00 N +ATOM 1699 C4 A B 53 5.439 12.240 -5.064 1.00 1.00 C +ATOM 1700 H5' A B 53 2.325 8.126 -1.712 1.00 1.00 H +ATOM 1701 H5'' A B 53 2.936 6.594 -2.370 1.00 1.00 H +ATOM 1702 H4' A B 53 2.294 8.068 -4.191 1.00 1.00 H +ATOM 1703 H3' A B 53 5.276 7.654 -3.877 1.00 1.00 H +ATOM 1704 H2' A B 53 5.675 9.123 -5.618 1.00 1.00 H +ATOM 1705 HO2' A B 53 3.814 7.795 -6.792 1.00 1.00 H +ATOM 1706 H1' A B 53 3.295 10.665 -5.373 1.00 1.00 H +ATOM 1707 H8 A B 53 5.649 10.523 -2.334 1.00 1.00 H +ATOM 1708 H61 A B 53 8.240 15.617 -4.726 1.00 1.00 H +ATOM 1709 H62 A B 53 8.180 14.538 -3.346 1.00 1.00 H +ATOM 1710 H2 A B 53 5.314 14.006 -7.718 1.00 1.00 H +ATOM 1711 P A B 54 5.174 5.625 -5.761 1.00 1.00 P +ATOM 1712 OP1 A B 54 4.547 4.301 -5.984 1.00 1.00 O +ATOM 1713 OP2 A B 54 6.354 5.743 -4.875 1.00 1.00 O +ATOM 1714 O5' A B 54 5.558 6.242 -7.200 1.00 1.00 O +ATOM 1715 C5' A B 54 4.707 6.028 -8.331 1.00 1.00 C +ATOM 1716 C4' A B 54 5.125 6.881 -9.527 1.00 1.00 C +ATOM 1717 O4' A B 54 5.204 8.255 -9.135 1.00 1.00 O +ATOM 1718 C3' A B 54 6.481 6.513 -10.121 1.00 1.00 C +ATOM 1719 O3' A B 54 6.308 5.566 -11.184 1.00 1.00 O +ATOM 1720 C2' A B 54 6.971 7.837 -10.682 1.00 1.00 C +ATOM 1721 O2' A B 54 6.512 8.040 -12.022 1.00 1.00 O +ATOM 1722 C1' A B 54 6.366 8.853 -9.724 1.00 1.00 C +ATOM 1723 N9 A B 54 7.274 9.241 -8.632 1.00 1.00 N +ATOM 1724 C8 A B 54 7.431 8.668 -7.396 1.00 1.00 C +ATOM 1725 N7 A B 54 8.338 9.246 -6.658 1.00 1.00 N +ATOM 1726 C5 A B 54 8.814 10.276 -7.464 1.00 1.00 C +ATOM 1727 C6 A B 54 9.794 11.262 -7.262 1.00 1.00 C +ATOM 1728 N6 A B 54 10.501 11.368 -6.136 1.00 1.00 N +ATOM 1729 N1 A B 54 10.014 12.127 -8.266 1.00 1.00 N +ATOM 1730 C2 A B 54 9.310 12.012 -9.385 1.00 1.00 C +ATOM 1731 N3 A B 54 8.369 11.133 -9.695 1.00 1.00 N +ATOM 1732 C4 A B 54 8.170 10.281 -8.668 1.00 1.00 C +ATOM 1733 H5' A B 54 3.682 6.278 -8.057 1.00 1.00 H +ATOM 1734 H5'' A B 54 4.752 4.976 -8.612 1.00 1.00 H +ATOM 1735 H4' A B 54 4.368 6.790 -10.302 1.00 1.00 H +ATOM 1736 H3' A B 54 7.158 6.137 -9.351 1.00 1.00 H +ATOM 1737 H2' A B 54 8.059 7.888 -10.634 1.00 1.00 H +ATOM 1738 HO2' A B 54 7.234 7.805 -12.609 1.00 1.00 H +ATOM 1739 H1' A B 54 6.074 9.747 -10.278 1.00 1.00 H +ATOM 1740 H8 A B 54 6.853 7.807 -7.061 1.00 1.00 H +ATOM 1741 H61 A B 54 11.196 12.098 -6.042 1.00 1.00 H +ATOM 1742 H62 A B 54 10.342 10.722 -5.378 1.00 1.00 H +ATOM 1743 H2 A B 54 9.540 12.745 -10.159 1.00 1.00 H +ATOM 1744 P G B 55 7.170 4.202 -11.225 1.00 1.00 P +ATOM 1745 OP1 G B 55 6.515 3.273 -12.174 1.00 1.00 O +ATOM 1746 OP2 G B 55 7.422 3.773 -9.832 1.00 1.00 O +ATOM 1747 O5' G B 55 8.573 4.668 -11.869 1.00 1.00 O +ATOM 1748 C5' G B 55 8.704 4.833 -13.284 1.00 1.00 C +ATOM 1749 C4' G B 55 10.007 5.539 -13.655 1.00 1.00 C +ATOM 1750 O4' G B 55 10.030 6.840 -13.072 1.00 1.00 O +ATOM 1751 C3' G B 55 11.275 4.840 -13.184 1.00 1.00 C +ATOM 1752 O3' G B 55 11.712 3.901 -14.177 1.00 1.00 O +ATOM 1753 C2' G B 55 12.267 5.984 -13.071 1.00 1.00 C +ATOM 1754 O2' G B 55 12.962 6.200 -14.303 1.00 1.00 O +ATOM 1755 C1' G B 55 11.380 7.171 -12.715 1.00 1.00 C +ATOM 1756 N9 G B 55 11.399 7.509 -11.282 1.00 1.00 N +ATOM 1757 C8 G B 55 10.541 7.117 -10.288 1.00 1.00 C +ATOM 1758 N7 G B 55 10.813 7.634 -9.122 1.00 1.00 N +ATOM 1759 C5 G B 55 11.933 8.425 -9.359 1.00 1.00 C +ATOM 1760 C6 G B 55 12.683 9.235 -8.462 1.00 1.00 C +ATOM 1761 O6 G B 55 12.498 9.416 -7.261 1.00 1.00 O +ATOM 1762 N1 G B 55 13.738 9.866 -9.106 1.00 1.00 N +ATOM 1763 C2 G B 55 14.037 9.737 -10.446 1.00 1.00 C +ATOM 1764 N2 G B 55 15.095 10.419 -10.882 1.00 1.00 N +ATOM 1765 N3 G B 55 13.333 8.977 -11.291 1.00 1.00 N +ATOM 1766 C4 G B 55 12.299 8.354 -10.680 1.00 1.00 C +ATOM 1767 H5' G B 55 7.864 5.423 -13.652 1.00 1.00 H +ATOM 1768 H5'' G B 55 8.684 3.853 -13.759 1.00 1.00 H +ATOM 1769 H4' G B 55 10.049 5.650 -14.737 1.00 1.00 H +ATOM 1770 H3' G B 55 11.119 4.359 -12.216 1.00 1.00 H +ATOM 1771 H2' G B 55 12.969 5.797 -12.258 1.00 1.00 H +ATOM 1772 HO2' G B 55 12.668 5.522 -14.917 1.00 1.00 H +ATOM 1773 H1' G B 55 11.698 8.042 -13.286 1.00 1.00 H +ATOM 1774 H8 G B 55 9.709 6.433 -10.455 1.00 1.00 H +ATOM 1775 H1 G B 55 14.316 10.461 -8.533 1.00 1.00 H +ATOM 1776 H21 G B 55 15.613 10.981 -10.252 1.00 1.00 H +ATOM 1777 H22 G B 55 15.365 10.366 -11.852 1.00 1.00 H +ATOM 1778 P A B 56 12.630 2.637 -13.775 1.00 1.00 P +ATOM 1779 OP1 A B 56 12.831 1.806 -14.985 1.00 1.00 O +ATOM 1780 OP2 A B 56 12.067 2.029 -12.549 1.00 1.00 O +ATOM 1781 O5' A B 56 14.042 3.317 -13.396 1.00 1.00 O +ATOM 1782 C5' A B 56 14.948 3.732 -14.422 1.00 1.00 C +ATOM 1783 C4' A B 56 16.211 4.360 -13.840 1.00 1.00 C +ATOM 1784 O4' A B 56 15.879 5.562 -13.152 1.00 1.00 O +ATOM 1785 C3' A B 56 16.949 3.489 -12.836 1.00 1.00 C +ATOM 1786 O3' A B 56 17.876 2.635 -13.520 1.00 1.00 O +ATOM 1787 C2' A B 56 17.695 4.515 -11.997 1.00 1.00 C +ATOM 1788 O2' A B 56 18.983 4.810 -12.549 1.00 1.00 O +ATOM 1789 C1' A B 56 16.776 5.733 -12.045 1.00 1.00 C +ATOM 1790 N9 A B 56 15.960 5.908 -10.833 1.00 1.00 N +ATOM 1791 C8 A B 56 14.800 5.277 -10.461 1.00 1.00 C +ATOM 1792 N7 A B 56 14.319 5.689 -9.320 1.00 1.00 N +ATOM 1793 C5 A B 56 15.224 6.662 -8.908 1.00 1.00 C +ATOM 1794 C6 A B 56 15.283 7.482 -7.769 1.00 1.00 C +ATOM 1795 N6 A B 56 14.370 7.446 -6.797 1.00 1.00 N +ATOM 1796 N1 A B 56 16.316 8.334 -7.675 1.00 1.00 N +ATOM 1797 C2 A B 56 17.222 8.364 -8.647 1.00 1.00 C +ATOM 1798 N3 A B 56 17.277 7.647 -9.759 1.00 1.00 N +ATOM 1799 C4 A B 56 16.227 6.802 -9.824 1.00 1.00 C +ATOM 1800 H5' A B 56 14.451 4.464 -15.061 1.00 1.00 H +ATOM 1801 H5'' A B 56 15.225 2.867 -15.024 1.00 1.00 H +ATOM 1802 H4' A B 56 16.889 4.607 -14.655 1.00 1.00 H +ATOM 1803 H3' A B 56 16.248 2.917 -12.226 1.00 1.00 H +ATOM 1804 H2' A B 56 17.787 4.163 -10.971 1.00 1.00 H +ATOM 1805 HO2' A B 56 19.415 5.426 -11.952 1.00 1.00 H +ATOM 1806 H1' A B 56 17.372 6.632 -12.200 1.00 1.00 H +ATOM 1807 H8 A B 56 14.326 4.503 -11.063 1.00 1.00 H +ATOM 1808 H61 A B 56 14.460 8.056 -6.000 1.00 1.00 H +ATOM 1809 H62 A B 56 13.590 6.807 -6.858 1.00 1.00 H +ATOM 1810 H2 A B 56 18.034 9.078 -8.507 1.00 1.00 H +ATOM 1811 P A B 57 18.144 1.127 -13.012 1.00 1.00 P +ATOM 1812 OP1 A B 57 19.016 0.455 -14.002 1.00 1.00 O +ATOM 1813 OP2 A B 57 16.841 0.526 -12.651 1.00 1.00 O +ATOM 1814 O5' A B 57 18.992 1.340 -11.658 1.00 1.00 O +ATOM 1815 C5' A B 57 20.399 1.591 -11.716 1.00 1.00 C +ATOM 1816 C4' A B 57 20.964 1.952 -10.344 1.00 1.00 C +ATOM 1817 O4' A B 57 20.350 3.141 -9.870 1.00 1.00 O +ATOM 1818 C3' A B 57 20.734 0.909 -9.263 1.00 1.00 C +ATOM 1819 O3' A B 57 21.811 -0.036 -9.255 1.00 1.00 O +ATOM 1820 C2' A B 57 20.746 1.727 -7.980 1.00 1.00 C +ATOM 1821 O2' A B 57 22.041 1.728 -7.373 1.00 1.00 O +ATOM 1822 C1' A B 57 20.336 3.126 -8.435 1.00 1.00 C +ATOM 1823 N9 A B 57 18.982 3.509 -8.001 1.00 1.00 N +ATOM 1824 C8 A B 57 17.774 3.188 -8.564 1.00 1.00 C +ATOM 1825 N7 A B 57 16.749 3.705 -7.943 1.00 1.00 N +ATOM 1826 C5 A B 57 17.320 4.419 -6.893 1.00 1.00 C +ATOM 1827 C6 A B 57 16.766 5.196 -5.862 1.00 1.00 C +ATOM 1828 N6 A B 57 15.455 5.392 -5.718 1.00 1.00 N +ATOM 1829 N1 A B 57 17.618 5.762 -4.992 1.00 1.00 N +ATOM 1830 C2 A B 57 18.924 5.565 -5.141 1.00 1.00 C +ATOM 1831 N3 A B 57 19.563 4.860 -6.062 1.00 1.00 N +ATOM 1832 C4 A B 57 18.680 4.305 -6.921 1.00 1.00 C +ATOM 1833 H5' A B 57 20.584 2.417 -12.403 1.00 1.00 H +ATOM 1834 H5'' A B 57 20.905 0.700 -12.086 1.00 1.00 H +ATOM 1835 H4' A B 57 22.033 2.132 -10.438 1.00 1.00 H +ATOM 1836 H3' A B 57 19.771 0.416 -9.402 1.00 1.00 H +ATOM 1837 H2' A B 57 19.998 1.337 -7.295 1.00 1.00 H +ATOM 1838 HO2' A B 57 21.951 1.316 -6.511 1.00 1.00 H +ATOM 1839 H1' A B 57 21.052 3.856 -8.056 1.00 1.00 H +ATOM 1840 H8 A B 57 17.677 2.558 -9.447 1.00 1.00 H +ATOM 1841 H61 A B 57 15.111 5.957 -4.964 1.00 1.00 H +ATOM 1842 H62 A B 57 14.807 4.969 -6.368 1.00 1.00 H +ATOM 1843 H2 A B 57 19.558 6.051 -4.398 1.00 1.00 H +ATOM 1844 P C B 58 21.639 -1.465 -8.530 1.00 1.00 P +ATOM 1845 OP1 C B 58 22.822 -2.293 -8.854 1.00 1.00 O +ATOM 1846 OP2 C B 58 20.281 -1.972 -8.828 1.00 1.00 O +ATOM 1847 O5' C B 58 21.701 -1.089 -6.963 1.00 1.00 O +ATOM 1848 C5' C B 58 22.958 -0.848 -6.319 1.00 1.00 C +ATOM 1849 C4' C B 58 22.785 -0.567 -4.827 1.00 1.00 C +ATOM 1850 O4' C B 58 22.073 0.648 -4.636 1.00 1.00 O +ATOM 1851 C3' C B 58 22.010 -1.629 -4.072 1.00 1.00 C +ATOM 1852 O3' C B 58 22.902 -2.649 -3.616 1.00 1.00 O +ATOM 1853 C2' C B 58 21.433 -0.861 -2.890 1.00 1.00 C +ATOM 1854 O2' C B 58 22.309 -0.909 -1.758 1.00 1.00 O +ATOM 1855 C1' C B 58 21.292 0.567 -3.428 1.00 1.00 C +ATOM 1856 N1 C B 58 19.906 0.933 -3.785 1.00 1.00 N +ATOM 1857 C2 C B 58 19.183 1.718 -2.901 1.00 1.00 C +ATOM 1858 O2 C B 58 19.699 2.103 -1.854 1.00 1.00 O +ATOM 1859 N3 C B 58 17.901 2.044 -3.228 1.00 1.00 N +ATOM 1860 C4 C B 58 17.355 1.618 -4.375 1.00 1.00 C +ATOM 1861 N4 C B 58 16.097 1.952 -4.665 1.00 1.00 N +ATOM 1862 C5 C B 58 18.099 0.809 -5.289 1.00 1.00 C +ATOM 1863 C6 C B 58 19.365 0.493 -4.957 1.00 1.00 C +ATOM 1864 H5' C B 58 23.438 0.011 -6.789 1.00 1.00 H +ATOM 1865 H5'' C B 58 23.596 -1.723 -6.445 1.00 1.00 H +ATOM 1866 H4' C B 58 23.769 -0.462 -4.373 1.00 1.00 H +ATOM 1867 H3' C B 58 21.214 -2.042 -4.694 1.00 1.00 H +ATOM 1868 H2' C B 58 20.448 -1.260 -2.633 1.00 1.00 H +ATOM 1869 HO2' C B 58 21.983 -0.273 -1.117 1.00 1.00 H +ATOM 1870 H1' C B 58 21.679 1.269 -2.694 1.00 1.00 H +ATOM 1871 H41 C B 58 15.565 2.523 -4.020 1.00 1.00 H +ATOM 1872 H42 C B 58 15.675 1.636 -5.526 1.00 1.00 H +ATOM 1873 H5 C B 58 17.659 0.465 -6.226 1.00 1.00 H +ATOM 1874 H6 C B 58 19.964 -0.120 -5.632 1.00 1.00 H +ATOM 1875 P C B 59 22.353 -4.124 -3.282 1.00 1.00 P +ATOM 1876 OP1 C B 59 23.480 -4.930 -2.763 1.00 1.00 O +ATOM 1877 OP2 C B 59 21.574 -4.604 -4.444 1.00 1.00 O +ATOM 1878 O5' C B 59 21.334 -3.842 -2.068 1.00 1.00 O +ATOM 1879 C5' C B 59 21.825 -3.357 -0.817 1.00 1.00 C +ATOM 1880 C4' C B 59 20.728 -2.686 0.002 1.00 1.00 C +ATOM 1881 O4' C B 59 20.081 -1.693 -0.781 1.00 1.00 O +ATOM 1882 C3' C B 59 19.630 -3.617 0.483 1.00 1.00 C +ATOM 1883 O3' C B 59 19.983 -4.149 1.765 1.00 1.00 O +ATOM 1884 C2' C B 59 18.424 -2.699 0.624 1.00 1.00 C +ATOM 1885 O2' C B 59 18.254 -2.266 1.978 1.00 1.00 O +ATOM 1886 C1' C B 59 18.740 -1.523 -0.304 1.00 1.00 C +ATOM 1887 N1 C B 59 17.842 -1.423 -1.479 1.00 1.00 N +ATOM 1888 C2 C B 59 16.799 -0.513 -1.405 1.00 1.00 C +ATOM 1889 O2 C B 59 16.643 0.165 -0.392 1.00 1.00 O +ATOM 1890 N3 C B 59 15.964 -0.400 -2.475 1.00 1.00 N +ATOM 1891 C4 C B 59 16.143 -1.150 -3.570 1.00 1.00 C +ATOM 1892 N4 C B 59 15.307 -1.015 -4.598 1.00 1.00 N +ATOM 1893 C5 C B 59 17.217 -2.092 -3.650 1.00 1.00 C +ATOM 1894 C6 C B 59 18.039 -2.196 -2.587 1.00 1.00 C +ATOM 1895 H5' C B 59 22.620 -2.633 -1.005 1.00 1.00 H +ATOM 1896 H5'' C B 59 22.233 -4.191 -0.248 1.00 1.00 H +ATOM 1897 H4' C B 59 21.179 -2.199 0.863 1.00 1.00 H +ATOM 1898 H3' C B 59 19.441 -4.410 -0.243 1.00 1.00 H +ATOM 1899 H2' C B 59 17.531 -3.217 0.269 1.00 1.00 H +ATOM 1900 HO2' C B 59 18.867 -1.541 2.126 1.00 1.00 H +ATOM 1901 H1' C B 59 18.687 -0.596 0.269 1.00 1.00 H +ATOM 1902 H41 C B 59 14.553 -0.355 -4.547 1.00 1.00 H +ATOM 1903 H42 C B 59 15.433 -1.575 -5.430 1.00 1.00 H +ATOM 1904 H5 C B 59 17.368 -2.702 -4.541 1.00 1.00 H +ATOM 1905 H6 C B 59 18.868 -2.904 -2.611 1.00 1.00 H +ATOM 1906 P G B 60 19.119 -5.333 2.429 1.00 1.00 P +ATOM 1907 OP1 G B 60 19.940 -5.967 3.485 1.00 1.00 O +ATOM 1908 OP2 G B 60 18.553 -6.160 1.339 1.00 1.00 O +ATOM 1909 O5' G B 60 17.908 -4.541 3.140 1.00 1.00 O +ATOM 1910 C5' G B 60 18.101 -3.890 4.401 1.00 1.00 C +ATOM 1911 C4' G B 60 16.773 -3.469 5.031 1.00 1.00 C +ATOM 1912 O4' G B 60 16.180 -2.416 4.276 1.00 1.00 O +ATOM 1913 C3' G B 60 15.735 -4.579 5.106 1.00 1.00 C +ATOM 1914 O3' G B 60 15.856 -5.283 6.347 1.00 1.00 O +ATOM 1915 C2' G B 60 14.410 -3.839 5.061 1.00 1.00 C +ATOM 1916 O2' G B 60 13.887 -3.619 6.375 1.00 1.00 O +ATOM 1917 C1' G B 60 14.750 -2.518 4.372 1.00 1.00 C +ATOM 1918 N9 G B 60 14.204 -2.409 3.010 1.00 1.00 N +ATOM 1919 C8 G B 60 14.857 -2.547 1.813 1.00 1.00 C +ATOM 1920 N7 G B 60 14.089 -2.396 0.771 1.00 1.00 N +ATOM 1921 C5 G B 60 12.832 -2.141 1.315 1.00 1.00 C +ATOM 1922 C6 G B 60 11.592 -1.894 0.665 1.00 1.00 C +ATOM 1923 O6 G B 60 11.357 -1.854 -0.541 1.00 1.00 O +ATOM 1924 N1 G B 60 10.570 -1.684 1.580 1.00 1.00 N +ATOM 1925 C2 G B 60 10.719 -1.708 2.951 1.00 1.00 C +ATOM 1926 N2 G B 60 9.618 -1.484 3.667 1.00 1.00 N +ATOM 1927 N3 G B 60 11.884 -1.939 3.564 1.00 1.00 N +ATOM 1928 C4 G B 60 12.894 -2.146 2.686 1.00 1.00 C +ATOM 1929 H5' G B 60 18.721 -3.004 4.252 1.00 1.00 H +ATOM 1930 H5'' G B 60 18.615 -4.573 5.077 1.00 1.00 H +ATOM 1931 H4' G B 60 16.965 -3.101 6.037 1.00 1.00 H +ATOM 1932 H3' G B 60 15.831 -5.256 4.256 1.00 1.00 H +ATOM 1933 H2' G B 60 13.696 -4.398 4.453 1.00 1.00 H +ATOM 1934 HO2' G B 60 13.177 -2.979 6.295 1.00 1.00 H +ATOM 1935 H1' G B 60 14.370 -1.694 4.973 1.00 1.00 H +ATOM 1936 H8 G B 60 15.923 -2.763 1.738 1.00 1.00 H +ATOM 1937 H1 G B 60 9.656 -1.502 1.192 1.00 1.00 H +ATOM 1938 H21 G B 60 8.738 -1.310 3.200 1.00 1.00 H +ATOM 1939 H22 G B 60 9.661 -1.489 4.675 1.00 1.00 H +ATOM 1940 P G B 61 15.228 -6.759 6.506 1.00 1.00 P +ATOM 1941 OP1 G B 61 15.612 -7.284 7.836 1.00 1.00 O +ATOM 1942 OP2 G B 61 15.549 -7.533 5.287 1.00 1.00 O +ATOM 1943 O5' G B 61 13.640 -6.470 6.518 1.00 1.00 O +ATOM 1944 C5' G B 61 13.045 -5.742 7.596 1.00 1.00 C +ATOM 1945 C4' G B 61 11.552 -5.500 7.370 1.00 1.00 C +ATOM 1946 O4' G B 61 11.351 -4.794 6.149 1.00 1.00 O +ATOM 1947 C3' G B 61 10.705 -6.760 7.278 1.00 1.00 C +ATOM 1948 O3' G B 61 10.221 -7.116 8.578 1.00 1.00 O +ATOM 1949 C2' G B 61 9.538 -6.344 6.397 1.00 1.00 C +ATOM 1950 O2' G B 61 8.392 -5.993 7.177 1.00 1.00 O +ATOM 1951 C1' G B 61 10.069 -5.148 5.614 1.00 1.00 C +ATOM 1952 N9 G B 61 10.222 -5.409 4.173 1.00 1.00 N +ATOM 1953 C8 G B 61 11.322 -5.853 3.487 1.00 1.00 C +ATOM 1954 N7 G B 61 11.133 -5.973 2.204 1.00 1.00 N +ATOM 1955 C5 G B 61 9.810 -5.579 2.021 1.00 1.00 C +ATOM 1956 C6 G B 61 9.040 -5.501 0.826 1.00 1.00 C +ATOM 1957 O6 G B 61 9.382 -5.771 -0.322 1.00 1.00 O +ATOM 1958 N1 G B 61 7.749 -5.057 1.082 1.00 1.00 N +ATOM 1959 C2 G B 61 7.258 -4.726 2.327 1.00 1.00 C +ATOM 1960 N2 G B 61 5.990 -4.319 2.371 1.00 1.00 N +ATOM 1961 N3 G B 61 7.980 -4.799 3.451 1.00 1.00 N +ATOM 1962 C4 G B 61 9.243 -5.232 3.222 1.00 1.00 C +ATOM 1963 H5' G B 61 13.549 -4.780 7.693 1.00 1.00 H +ATOM 1964 H5'' G B 61 13.176 -6.306 8.518 1.00 1.00 H +ATOM 1965 H4' G B 61 11.173 -4.884 8.183 1.00 1.00 H +ATOM 1966 H3' G B 61 11.268 -7.577 6.823 1.00 1.00 H +ATOM 1967 H2' G B 61 9.300 -7.149 5.704 1.00 1.00 H +ATOM 1968 HO2' G B 61 7.841 -5.426 6.633 1.00 1.00 H +ATOM 1969 H1' G B 61 9.388 -4.308 5.746 1.00 1.00 H +ATOM 1970 H8 G B 61 12.271 -6.085 3.972 1.00 1.00 H +ATOM 1971 H1 G B 61 7.141 -4.976 0.280 1.00 1.00 H +ATOM 1972 H21 G B 61 5.448 -4.265 1.520 1.00 1.00 H +ATOM 1973 H22 G B 61 5.573 -4.063 3.254 1.00 1.00 H +ATOM 1974 P G B 62 9.588 -8.575 8.851 1.00 1.00 P +ATOM 1975 OP1 G B 62 9.379 -8.721 10.309 1.00 1.00 O +ATOM 1976 OP2 G B 62 10.400 -9.572 8.121 1.00 1.00 O +ATOM 1977 O5' G B 62 8.141 -8.486 8.141 1.00 1.00 O +ATOM 1978 C5' G B 62 7.108 -7.649 8.677 1.00 1.00 C +ATOM 1979 C4' G B 62 5.798 -7.801 7.902 1.00 1.00 C +ATOM 1980 O4' G B 62 5.943 -7.271 6.589 1.00 1.00 O +ATOM 1981 C3' G B 62 5.335 -9.237 7.739 1.00 1.00 C +ATOM 1982 O3' G B 62 4.488 -9.599 8.835 1.00 1.00 O +ATOM 1983 C2' G B 62 4.535 -9.205 6.442 1.00 1.00 C +ATOM 1984 O2' G B 62 3.144 -8.979 6.693 1.00 1.00 O +ATOM 1985 C1' G B 62 5.158 -8.043 5.665 1.00 1.00 C +ATOM 1986 N9 G B 62 6.062 -8.464 4.587 1.00 1.00 N +ATOM 1987 C8 G B 62 7.379 -8.835 4.673 1.00 1.00 C +ATOM 1988 N7 G B 62 7.917 -9.146 3.527 1.00 1.00 N +ATOM 1989 C5 G B 62 6.882 -8.968 2.612 1.00 1.00 C +ATOM 1990 C6 G B 62 6.871 -9.155 1.202 1.00 1.00 C +ATOM 1991 O6 G B 62 7.791 -9.520 0.473 1.00 1.00 O +ATOM 1992 N1 G B 62 5.626 -8.864 0.660 1.00 1.00 N +ATOM 1993 C2 G B 62 4.527 -8.447 1.382 1.00 1.00 C +ATOM 1994 N2 G B 62 3.416 -8.218 0.683 1.00 1.00 N +ATOM 1995 N3 G B 62 4.536 -8.272 2.706 1.00 1.00 N +ATOM 1996 C4 G B 62 5.743 -8.550 3.253 1.00 1.00 C +ATOM 1997 H5' G B 62 7.432 -6.609 8.626 1.00 1.00 H +ATOM 1998 H5'' G B 62 6.938 -7.918 9.719 1.00 1.00 H +ATOM 1999 H4' G B 62 5.020 -7.238 8.415 1.00 1.00 H +ATOM 2000 H3' G B 62 6.188 -9.909 7.655 1.00 1.00 H +ATOM 2001 H2' G B 62 4.680 -10.140 5.894 1.00 1.00 H +ATOM 2002 HO2' G B 62 3.049 -8.789 7.630 1.00 1.00 H +ATOM 2003 H1' G B 62 4.370 -7.421 5.241 1.00 1.00 H +ATOM 2004 H8 G B 62 7.927 -8.867 5.615 1.00 1.00 H +ATOM 2005 H1 G B 62 5.541 -8.974 -0.341 1.00 1.00 H +ATOM 2006 H21 G B 62 3.412 -8.351 -0.319 1.00 1.00 H +ATOM 2007 H22 G B 62 2.578 -7.910 1.156 1.00 1.00 H +ATOM 2008 P G B 63 4.626 -11.043 9.535 1.00 1.00 P +ATOM 2009 OP1 G B 63 3.491 -11.214 10.470 1.00 1.00 O +ATOM 2010 OP2 G B 63 6.014 -11.191 10.027 1.00 1.00 O +ATOM 2011 O5' G B 63 4.418 -12.056 8.302 1.00 1.00 O +ATOM 2012 C5' G B 63 3.104 -12.394 7.850 1.00 1.00 C +ATOM 2013 C4' G B 63 3.153 -13.226 6.572 1.00 1.00 C +ATOM 2014 O4' G B 63 3.670 -12.437 5.504 1.00 1.00 O +ATOM 2015 C3' G B 63 4.033 -14.458 6.670 1.00 1.00 C +ATOM 2016 O3' G B 63 3.242 -15.579 7.076 1.00 1.00 O +ATOM 2017 C2' G B 63 4.527 -14.662 5.246 1.00 1.00 C +ATOM 2018 O2' G B 63 3.688 -15.581 4.543 1.00 1.00 O +ATOM 2019 C1' G B 63 4.468 -13.258 4.634 1.00 1.00 C +ATOM 2020 N9 G B 63 5.783 -12.608 4.523 1.00 1.00 N +ATOM 2021 C8 G B 63 6.498 -11.968 5.504 1.00 1.00 C +ATOM 2022 N7 G B 63 7.636 -11.483 5.098 1.00 1.00 N +ATOM 2023 C5 G B 63 7.685 -11.823 3.750 1.00 1.00 C +ATOM 2024 C6 G B 63 8.692 -11.560 2.781 1.00 1.00 C +ATOM 2025 O6 G B 63 9.757 -10.965 2.930 1.00 1.00 O +ATOM 2026 N1 G B 63 8.349 -12.074 1.539 1.00 1.00 N +ATOM 2027 C2 G B 63 7.186 -12.758 1.259 1.00 1.00 C +ATOM 2028 N2 G B 63 7.037 -13.174 0.002 1.00 1.00 N +ATOM 2029 N3 G B 63 6.237 -13.009 2.167 1.00 1.00 N +ATOM 2030 C4 G B 63 6.554 -12.513 3.387 1.00 1.00 C +ATOM 2031 H5' G B 63 2.547 -11.477 7.657 1.00 1.00 H +ATOM 2032 H5'' G B 63 2.595 -12.964 8.627 1.00 1.00 H +ATOM 2033 H4' G B 63 2.141 -13.535 6.313 1.00 1.00 H +ATOM 2034 H3' G B 63 4.866 -14.287 7.354 1.00 1.00 H +ATOM 2035 H2' G B 63 5.560 -15.017 5.261 1.00 1.00 H +ATOM 2036 HO2' G B 63 4.167 -16.408 4.475 1.00 1.00 H +ATOM 2037 H1' G B 63 4.005 -13.300 3.650 1.00 1.00 H +ATOM 2038 H8 G B 63 6.144 -11.872 6.531 1.00 1.00 H +ATOM 2039 H1 G B 63 9.018 -11.926 0.797 1.00 1.00 H +ATOM 2040 H21 G B 63 7.757 -12.983 -0.682 1.00 1.00 H +ATOM 2041 H22 G B 63 6.208 -13.680 -0.269 1.00 1.00 H +ATOM 2042 P A B 64 3.932 -16.858 7.767 1.00 1.00 P +ATOM 2043 OP1 A B 64 2.872 -17.848 8.066 1.00 1.00 O +ATOM 2044 OP2 A B 64 4.819 -16.378 8.849 1.00 1.00 O +ATOM 2045 O5' A B 64 4.851 -17.446 6.582 1.00 1.00 O +ATOM 2046 C5' A B 64 6.112 -18.054 6.876 1.00 1.00 C +ATOM 2047 C4' A B 64 6.615 -18.893 5.705 1.00 1.00 C +ATOM 2048 O4' A B 64 5.739 -20.008 5.507 1.00 1.00 O +ATOM 2049 C3' A B 64 6.697 -18.127 4.388 1.00 1.00 C +ATOM 2050 O3' A B 64 8.062 -17.793 4.115 1.00 1.00 O +ATOM 2051 C2' A B 64 6.190 -19.112 3.346 1.00 1.00 C +ATOM 2052 O2' A B 64 7.269 -19.830 2.737 1.00 1.00 O +ATOM 2053 C1' A B 64 5.293 -20.040 4.147 1.00 1.00 C +ATOM 2054 N9 A B 64 3.871 -19.649 4.138 1.00 1.00 N +ATOM 2055 C8 A B 64 3.129 -19.105 5.153 1.00 1.00 C +ATOM 2056 N7 A B 64 1.881 -18.890 4.838 1.00 1.00 N +ATOM 2057 C5 A B 64 1.791 -19.324 3.519 1.00 1.00 C +ATOM 2058 C6 A B 64 0.725 -19.363 2.606 1.00 1.00 C +ATOM 2059 N6 A B 64 -0.504 -18.938 2.900 1.00 1.00 N +ATOM 2060 N1 A B 64 0.980 -19.855 1.382 1.00 1.00 N +ATOM 2061 C2 A B 64 2.208 -20.274 1.095 1.00 1.00 C +ATOM 2062 N3 A B 64 3.287 -20.287 1.862 1.00 1.00 N +ATOM 2063 C4 A B 64 2.999 -19.788 3.083 1.00 1.00 C +ATOM 2064 H5' A B 64 6.005 -18.691 7.752 1.00 1.00 H +ATOM 2065 H5'' A B 64 6.841 -17.272 7.091 1.00 1.00 H +ATOM 2066 H4' A B 64 7.605 -19.275 5.950 1.00 1.00 H +ATOM 2067 H3' A B 64 6.068 -17.236 4.418 1.00 1.00 H +ATOM 2068 H2' A B 64 5.601 -18.586 2.591 1.00 1.00 H +ATOM 2069 HO2' A B 64 7.570 -20.485 3.371 1.00 1.00 H +ATOM 2070 H1' A B 64 5.386 -21.054 3.762 1.00 1.00 H +ATOM 2071 H8 A B 64 3.542 -18.874 6.134 1.00 1.00 H +ATOM 2072 H61 A B 64 -1.235 -18.988 2.205 1.00 1.00 H +ATOM 2073 H62 A B 64 -0.704 -18.567 3.818 1.00 1.00 H +ATOM 2074 H2 A B 64 2.344 -20.661 0.085 1.00 1.00 H +ATOM 2075 P A B 65 8.428 -16.515 3.207 1.00 1.00 P +ATOM 2076 OP1 A B 65 9.684 -15.926 3.722 1.00 1.00 O +ATOM 2077 OP2 A B 65 7.215 -15.674 3.084 1.00 1.00 O +ATOM 2078 O5' A B 65 8.732 -17.175 1.771 1.00 1.00 O +ATOM 2079 C5' A B 65 8.196 -16.597 0.578 1.00 1.00 C +ATOM 2080 C4' A B 65 7.370 -17.610 -0.208 1.00 1.00 C +ATOM 2081 O4' A B 65 6.372 -18.177 0.652 1.00 1.00 O +ATOM 2082 C3' A B 65 6.653 -17.017 -1.419 1.00 1.00 C +ATOM 2083 O3' A B 65 7.398 -17.301 -2.611 1.00 1.00 O +ATOM 2084 C2' A B 65 5.331 -17.766 -1.452 1.00 1.00 C +ATOM 2085 O2' A B 65 5.426 -18.950 -2.251 1.00 1.00 O +ATOM 2086 C1' A B 65 5.094 -18.108 0.014 1.00 1.00 C +ATOM 2087 N9 A B 65 4.287 -17.112 0.739 1.00 1.00 N +ATOM 2088 C8 A B 65 4.651 -16.313 1.793 1.00 1.00 C +ATOM 2089 N7 A B 65 3.692 -15.539 2.223 1.00 1.00 N +ATOM 2090 C5 A B 65 2.618 -15.849 1.391 1.00 1.00 C +ATOM 2091 C6 A B 65 1.298 -15.372 1.324 1.00 1.00 C +ATOM 2092 N6 A B 65 0.817 -14.437 2.144 1.00 1.00 N +ATOM 2093 N1 A B 65 0.500 -15.897 0.378 1.00 1.00 N +ATOM 2094 C2 A B 65 0.985 -16.827 -0.436 1.00 1.00 C +ATOM 2095 N3 A B 65 2.199 -17.352 -0.472 1.00 1.00 N +ATOM 2096 C4 A B 65 2.974 -16.807 0.487 1.00 1.00 C +ATOM 2097 H5' A B 65 9.015 -16.242 -0.047 1.00 1.00 H +ATOM 2098 H5'' A B 65 7.562 -15.751 0.847 1.00 1.00 H +ATOM 2099 H4' A B 65 8.027 -18.408 -0.546 1.00 1.00 H +ATOM 2100 H3' A B 65 6.494 -15.945 -1.292 1.00 1.00 H +ATOM 2101 H2' A B 65 4.537 -17.111 -1.819 1.00 1.00 H +ATOM 2102 HO2' A B 65 4.714 -19.534 -1.982 1.00 1.00 H +ATOM 2103 H1' A B 65 4.603 -19.078 0.087 1.00 1.00 H +ATOM 2104 H8 A B 65 5.649 -16.324 2.232 1.00 1.00 H +ATOM 2105 H61 A B 65 -0.141 -14.129 2.053 1.00 1.00 H +ATOM 2106 H62 A B 65 1.410 -14.038 2.857 1.00 1.00 H +ATOM 2107 H2 A B 65 0.285 -17.211 -1.179 1.00 1.00 H +ATOM 2108 P A B 66 7.768 -16.129 -3.658 1.00 1.00 P +ATOM 2109 OP1 A B 66 8.584 -16.721 -4.742 1.00 1.00 O +ATOM 2110 OP2 A B 66 8.290 -14.974 -2.892 1.00 1.00 O +ATOM 2111 O5' A B 66 6.336 -15.718 -4.276 1.00 1.00 O +ATOM 2112 C5' A B 66 5.777 -16.450 -5.372 1.00 1.00 C +ATOM 2113 C4' A B 66 4.344 -16.015 -5.675 1.00 1.00 C +ATOM 2114 O4' A B 66 3.520 -16.311 -4.545 1.00 1.00 O +ATOM 2115 C3' A B 66 4.189 -14.525 -5.972 1.00 1.00 C +ATOM 2116 O3' A B 66 4.111 -14.318 -7.388 1.00 1.00 O +ATOM 2117 C2' A B 66 2.854 -14.166 -5.337 1.00 1.00 C +ATOM 2118 O2' A B 66 1.775 -14.309 -6.266 1.00 1.00 O +ATOM 2119 C1' A B 66 2.739 -15.163 -4.196 1.00 1.00 C +ATOM 2120 N9 A B 66 3.245 -14.646 -2.911 1.00 1.00 N +ATOM 2121 C8 A B 66 4.534 -14.590 -2.450 1.00 1.00 C +ATOM 2122 N7 A B 66 4.649 -14.054 -1.267 1.00 1.00 N +ATOM 2123 C5 A B 66 3.340 -13.733 -0.920 1.00 1.00 C +ATOM 2124 C6 A B 66 2.780 -13.134 0.222 1.00 1.00 C +ATOM 2125 N6 A B 66 3.505 -12.730 1.265 1.00 1.00 N +ATOM 2126 N1 A B 66 1.448 -12.968 0.238 1.00 1.00 N +ATOM 2127 C2 A B 66 0.732 -13.368 -0.806 1.00 1.00 C +ATOM 2128 N3 A B 66 1.139 -13.938 -1.930 1.00 1.00 N +ATOM 2129 C4 A B 66 2.478 -14.092 -1.916 1.00 1.00 C +ATOM 2130 H5' A B 66 5.781 -17.513 -5.128 1.00 1.00 H +ATOM 2131 H5'' A B 66 6.392 -16.287 -6.258 1.00 1.00 H +ATOM 2132 H4' A B 66 3.976 -16.584 -6.526 1.00 1.00 H +ATOM 2133 H3' A B 66 5.001 -13.951 -5.527 1.00 1.00 H +ATOM 2134 H2' A B 66 2.889 -13.151 -4.936 1.00 1.00 H +ATOM 2135 HO2' A B 66 2.160 -14.367 -7.144 1.00 1.00 H +ATOM 2136 H1' A B 66 1.697 -15.457 -4.079 1.00 1.00 H +ATOM 2137 H8 A B 66 5.387 -14.960 -3.021 1.00 1.00 H +ATOM 2138 H61 A B 66 3.047 -12.305 2.059 1.00 1.00 H +ATOM 2139 H62 A B 66 4.514 -12.850 1.266 1.00 1.00 H +ATOM 2140 H2 A B 66 -0.342 -13.202 -0.726 1.00 1.00 H +ATOM 2141 P C B 67 4.940 -13.126 -8.087 1.00 1.00 P +ATOM 2142 OP1 C B 67 4.676 -13.172 -9.543 1.00 1.00 O +ATOM 2143 OP2 C B 67 6.333 -13.182 -7.590 1.00 1.00 O +ATOM 2144 O5' C B 67 4.243 -11.801 -7.489 1.00 1.00 O +ATOM 2145 C5' C B 67 2.894 -11.467 -7.830 1.00 1.00 C +ATOM 2146 C4' C B 67 2.262 -10.545 -6.789 1.00 1.00 C +ATOM 2147 O4' C B 67 2.383 -11.133 -5.494 1.00 1.00 O +ATOM 2148 C3' C B 67 2.895 -9.163 -6.701 1.00 1.00 C +ATOM 2149 O3' C B 67 2.197 -8.251 -7.554 1.00 1.00 O +ATOM 2150 C2' C B 67 2.682 -8.768 -5.250 1.00 1.00 C +ATOM 2151 O2' C B 67 1.460 -8.042 -5.082 1.00 1.00 O +ATOM 2152 C1' C B 67 2.638 -10.108 -4.523 1.00 1.00 C +ATOM 2153 N1 C B 67 3.893 -10.446 -3.833 1.00 1.00 N +ATOM 2154 C2 C B 67 4.099 -9.888 -2.582 1.00 1.00 C +ATOM 2155 O2 C B 67 3.253 -9.139 -2.095 1.00 1.00 O +ATOM 2156 N3 C B 67 5.250 -10.190 -1.920 1.00 1.00 N +ATOM 2157 C4 C B 67 6.162 -11.006 -2.465 1.00 1.00 C +ATOM 2158 N4 C B 67 7.279 -11.280 -1.792 1.00 1.00 N +ATOM 2159 C5 C B 67 5.955 -11.584 -3.757 1.00 1.00 C +ATOM 2160 C6 C B 67 4.812 -11.279 -4.403 1.00 1.00 C +ATOM 2161 H5' C B 67 2.306 -12.383 -7.896 1.00 1.00 H +ATOM 2162 H5'' C B 67 2.885 -10.968 -8.800 1.00 1.00 H +ATOM 2163 H4' C B 67 1.205 -10.432 -7.016 1.00 1.00 H +ATOM 2164 H3' C B 67 3.959 -9.202 -6.943 1.00 1.00 H +ATOM 2165 H2' C B 67 3.531 -8.182 -4.895 1.00 1.00 H +ATOM 2166 HO2' C B 67 0.864 -8.319 -5.783 1.00 1.00 H +ATOM 2167 H1' C B 67 1.828 -10.096 -3.796 1.00 1.00 H +ATOM 2168 H41 C B 67 7.432 -10.876 -0.881 1.00 1.00 H +ATOM 2169 H42 C B 67 7.974 -11.895 -2.193 1.00 1.00 H +ATOM 2170 H5 C B 67 6.696 -12.247 -4.204 1.00 1.00 H +ATOM 2171 H6 C B 67 4.620 -11.703 -5.388 1.00 1.00 H +ATOM 2172 P U B 68 2.913 -6.910 -8.086 1.00 1.00 P +ATOM 2173 OP1 U B 68 1.966 -6.201 -8.978 1.00 1.00 O +ATOM 2174 OP2 U B 68 4.260 -7.271 -8.581 1.00 1.00 O +ATOM 2175 O5' U B 68 3.087 -6.039 -6.741 1.00 1.00 O +ATOM 2176 C5' U B 68 1.943 -5.615 -5.992 1.00 1.00 C +ATOM 2177 C4' U B 68 2.342 -4.941 -4.679 1.00 1.00 C +ATOM 2178 O4' U B 68 3.027 -5.864 -3.837 1.00 1.00 O +ATOM 2179 C3' U B 68 3.269 -3.747 -4.839 1.00 1.00 C +ATOM 2180 O3' U B 68 2.497 -2.555 -5.012 1.00 1.00 O +ATOM 2181 C2' U B 68 4.012 -3.698 -3.513 1.00 1.00 C +ATOM 2182 O2' U B 68 3.377 -2.801 -2.595 1.00 1.00 O +ATOM 2183 C1' U B 68 3.958 -5.144 -3.011 1.00 1.00 C +ATOM 2184 N1 U B 68 5.255 -5.851 -3.082 1.00 1.00 N +ATOM 2185 C2 U B 68 6.048 -5.857 -1.950 1.00 1.00 C +ATOM 2186 O2 U B 68 5.708 -5.295 -0.911 1.00 1.00 O +ATOM 2187 N3 U B 68 7.251 -6.532 -2.054 1.00 1.00 N +ATOM 2188 C4 U B 68 7.722 -7.193 -3.175 1.00 1.00 C +ATOM 2189 O4 U B 68 8.812 -7.763 -3.155 1.00 1.00 O +ATOM 2190 C5 U B 68 6.829 -7.136 -4.311 1.00 1.00 C +ATOM 2191 C6 U B 68 5.645 -6.480 -4.233 1.00 1.00 C +ATOM 2192 H5' U B 68 1.324 -6.484 -5.771 1.00 1.00 H +ATOM 2193 H5'' U B 68 1.367 -4.911 -6.592 1.00 1.00 H +ATOM 2194 H4' U B 68 1.440 -4.616 -4.165 1.00 1.00 H +ATOM 2195 H3' U B 68 3.963 -3.901 -5.669 1.00 1.00 H +ATOM 2196 H2' U B 68 5.049 -3.408 -3.680 1.00 1.00 H +ATOM 2197 HO2' U B 68 3.188 -3.296 -1.795 1.00 1.00 H +ATOM 2198 H1' U B 68 3.599 -5.151 -1.982 1.00 1.00 H +ATOM 2199 H3 U B 68 7.841 -6.545 -1.234 1.00 1.00 H +ATOM 2200 H5 U B 68 7.112 -7.626 -5.242 1.00 1.00 H +ATOM 2201 H6 U B 68 4.992 -6.451 -5.105 1.00 1.00 H +ATOM 2202 P U B 69 3.171 -1.213 -5.597 1.00 1.00 P +ATOM 2203 OP1 U B 69 2.092 -0.347 -6.125 1.00 1.00 O +ATOM 2204 OP2 U B 69 4.299 -1.604 -6.472 1.00 1.00 O +ATOM 2205 O5' U B 69 3.776 -0.517 -4.276 1.00 1.00 O +ATOM 2206 C5' U B 69 2.919 -0.137 -3.195 1.00 1.00 C +ATOM 2207 C4' U B 69 3.716 0.196 -1.936 1.00 1.00 C +ATOM 2208 O4' U B 69 4.419 -0.962 -1.481 1.00 1.00 O +ATOM 2209 C3' U B 69 4.762 1.281 -2.126 1.00 1.00 C +ATOM 2210 O3' U B 69 4.185 2.569 -1.862 1.00 1.00 O +ATOM 2211 C2' U B 69 5.811 0.941 -1.076 1.00 1.00 C +ATOM 2212 O2' U B 69 5.580 1.633 0.151 1.00 1.00 O +ATOM 2213 C1' U B 69 5.668 -0.560 -0.890 1.00 1.00 C +ATOM 2214 N1 U B 69 6.746 -1.321 -1.546 1.00 1.00 N +ATOM 2215 C2 U B 69 7.840 -1.692 -0.786 1.00 1.00 C +ATOM 2216 O2 U B 69 7.939 -1.403 0.405 1.00 1.00 O +ATOM 2217 N3 U B 69 8.822 -2.409 -1.446 1.00 1.00 N +ATOM 2218 C4 U B 69 8.805 -2.781 -2.780 1.00 1.00 C +ATOM 2219 O4 U B 69 9.736 -3.421 -3.265 1.00 1.00 O +ATOM 2220 C5 U B 69 7.624 -2.351 -3.495 1.00 1.00 C +ATOM 2221 C6 U B 69 6.649 -1.648 -2.870 1.00 1.00 C +ATOM 2222 H5' U B 69 2.235 -0.957 -2.977 1.00 1.00 H +ATOM 2223 H5'' U B 69 2.339 0.739 -3.490 1.00 1.00 H +ATOM 2224 H4' U B 69 3.026 0.507 -1.154 1.00 1.00 H +ATOM 2225 H3' U B 69 5.189 1.233 -3.129 1.00 1.00 H +ATOM 2226 H2' U B 69 6.804 1.157 -1.469 1.00 1.00 H +ATOM 2227 HO2' U B 69 6.337 1.464 0.719 1.00 1.00 H +ATOM 2228 H1' U B 69 5.654 -0.794 0.175 1.00 1.00 H +ATOM 2229 H3 U B 69 9.629 -2.687 -0.904 1.00 1.00 H +ATOM 2230 H5 U B 69 7.517 -2.593 -4.553 1.00 1.00 H +ATOM 2231 H6 U B 69 5.769 -1.339 -3.433 1.00 1.00 H +ATOM 2232 P G B 70 4.870 3.915 -2.435 1.00 1.00 P +ATOM 2233 OP1 G B 70 3.982 5.058 -2.123 1.00 1.00 O +ATOM 2234 OP2 G B 70 5.292 3.663 -3.829 1.00 1.00 O +ATOM 2235 O5' G B 70 6.190 4.040 -1.527 1.00 1.00 O +ATOM 2236 C5' G B 70 6.075 4.066 -0.106 1.00 1.00 C +ATOM 2237 C4' G B 70 7.376 3.649 0.569 1.00 1.00 C +ATOM 2238 O4' G B 70 7.839 2.431 -0.011 1.00 1.00 O +ATOM 2239 C3' G B 70 8.519 4.642 0.428 1.00 1.00 C +ATOM 2240 O3' G B 70 8.508 5.549 1.539 1.00 1.00 O +ATOM 2241 C2' G B 70 9.757 3.763 0.513 1.00 1.00 C +ATOM 2242 O2' G B 70 10.296 3.760 1.839 1.00 1.00 O +ATOM 2243 C1' G B 70 9.263 2.377 0.113 1.00 1.00 C +ATOM 2244 N9 G B 70 9.845 1.880 -1.145 1.00 1.00 N +ATOM 2245 C8 G B 70 9.326 1.887 -2.415 1.00 1.00 C +ATOM 2246 N7 G B 70 10.091 1.312 -3.301 1.00 1.00 N +ATOM 2247 C5 G B 70 11.200 0.896 -2.568 1.00 1.00 C +ATOM 2248 C6 G B 70 12.370 0.210 -2.993 1.00 1.00 C +ATOM 2249 O6 G B 70 12.659 -0.178 -4.123 1.00 1.00 O +ATOM 2250 N1 G B 70 13.243 -0.012 -1.935 1.00 1.00 N +ATOM 2251 C2 G B 70 13.017 0.375 -0.631 1.00 1.00 C +ATOM 2252 N2 G B 70 13.973 0.080 0.248 1.00 1.00 N +ATOM 2253 N3 G B 70 11.918 1.017 -0.230 1.00 1.00 N +ATOM 2254 C4 G B 70 11.058 1.245 -1.248 1.00 1.00 C +ATOM 2255 H5' G B 70 5.282 3.378 0.198 1.00 1.00 H +ATOM 2256 H5'' G B 70 5.812 5.072 0.213 1.00 1.00 H +ATOM 2257 H4' G B 70 7.187 3.477 1.625 1.00 1.00 H +ATOM 2258 H3' G B 70 8.470 5.170 -0.527 1.00 1.00 H +ATOM 2259 H2' G B 70 10.505 4.111 -0.203 1.00 1.00 H +ATOM 2260 HO2' G B 70 9.570 3.931 2.445 1.00 1.00 H +ATOM 2261 H1' G B 70 9.510 1.671 0.905 1.00 1.00 H +ATOM 2262 H8 G B 70 8.364 2.335 -2.662 1.00 1.00 H +ATOM 2263 H1 G B 70 14.098 -0.499 -2.159 1.00 1.00 H +ATOM 2264 H21 G B 70 14.809 -0.406 -0.055 1.00 1.00 H +ATOM 2265 H22 G B 70 13.864 0.339 1.218 1.00 1.00 H +ATOM 2266 P G B 71 9.429 6.873 1.542 1.00 1.00 P +ATOM 2267 OP1 G B 71 8.822 7.855 2.469 1.00 1.00 O +ATOM 2268 OP2 G B 71 9.691 7.255 0.137 1.00 1.00 O +ATOM 2269 O5' G B 71 10.821 6.363 2.193 1.00 1.00 O +ATOM 2270 C5' G B 71 10.962 6.215 3.614 1.00 1.00 C +ATOM 2271 C4' G B 71 12.434 6.222 4.045 1.00 1.00 C +ATOM 2272 O4' G B 71 13.001 4.911 3.905 1.00 1.00 O +ATOM 2273 C3' G B 71 13.308 7.180 3.243 1.00 1.00 C +ATOM 2274 O3' G B 71 13.460 8.410 3.959 1.00 1.00 O +ATOM 2275 C2' G B 71 14.645 6.462 3.155 1.00 1.00 C +ATOM 2276 O2' G B 71 15.497 6.796 4.256 1.00 1.00 O +ATOM 2277 C1' G B 71 14.242 4.999 3.187 1.00 1.00 C +ATOM 2278 N9 G B 71 14.007 4.426 1.856 1.00 1.00 N +ATOM 2279 C8 G B 71 12.804 4.137 1.266 1.00 1.00 C +ATOM 2280 N7 G B 71 12.908 3.648 0.063 1.00 1.00 N +ATOM 2281 C5 G B 71 14.280 3.608 -0.165 1.00 1.00 C +ATOM 2282 C6 G B 71 14.997 3.166 -1.311 1.00 1.00 C +ATOM 2283 O6 G B 71 14.551 2.719 -2.365 1.00 1.00 O +ATOM 2284 N1 G B 71 16.367 3.292 -1.133 1.00 1.00 N +ATOM 2285 C2 G B 71 16.976 3.779 0.004 1.00 1.00 C +ATOM 2286 N2 G B 71 18.307 3.823 -0.015 1.00 1.00 N +ATOM 2287 N3 G B 71 16.304 4.196 1.084 1.00 1.00 N +ATOM 2288 C4 G B 71 14.963 4.082 0.927 1.00 1.00 C +ATOM 2289 H5' G B 71 10.508 5.272 3.919 1.00 1.00 H +ATOM 2290 H5'' G B 71 10.443 7.035 4.110 1.00 1.00 H +ATOM 2291 H4' G B 71 12.484 6.505 5.097 1.00 1.00 H +ATOM 2292 H3' G B 71 12.890 7.346 2.250 1.00 1.00 H +ATOM 2293 H2' G B 71 15.129 6.688 2.207 1.00 1.00 H +ATOM 2294 HO2' G B 71 16.394 6.842 3.916 1.00 1.00 H +ATOM 2295 H1' G B 71 15.005 4.419 3.703 1.00 1.00 H +ATOM 2296 H8 G B 71 11.846 4.297 1.760 1.00 1.00 H +ATOM 2297 H1 G B 71 16.944 2.996 -1.906 1.00 1.00 H +ATOM 2298 H21 G B 71 18.813 3.506 -0.832 1.00 1.00 H +ATOM 2299 H22 G B 71 18.813 4.170 0.787 1.00 1.00 H +ATOM 2300 P U B 72 13.560 9.811 3.171 1.00 1.00 P +ATOM 2301 OP1 U B 72 13.570 10.902 4.171 1.00 1.00 O +ATOM 2302 OP2 U B 72 12.544 9.807 2.096 1.00 1.00 O +ATOM 2303 O5' U B 72 15.019 9.743 2.488 1.00 1.00 O +ATOM 2304 C5' U B 72 16.200 9.957 3.268 1.00 1.00 C +ATOM 2305 C4' U B 72 17.464 9.895 2.412 1.00 1.00 C +ATOM 2306 O4' U B 72 17.621 8.586 1.861 1.00 1.00 O +ATOM 2307 C3' U B 72 17.474 10.853 1.232 1.00 1.00 C +ATOM 2308 O3' U B 72 18.042 12.110 1.619 1.00 1.00 O +ATOM 2309 C2' U B 72 18.380 10.163 0.230 1.00 1.00 C +ATOM 2310 O2' U B 72 19.743 10.575 0.375 1.00 1.00 O +ATOM 2311 C1' U B 72 18.203 8.688 0.549 1.00 1.00 C +ATOM 2312 N1 U B 72 17.309 7.992 -0.397 1.00 1.00 N +ATOM 2313 C2 U B 72 17.876 7.438 -1.528 1.00 1.00 C +ATOM 2314 O2 U B 72 19.079 7.529 -1.769 1.00 1.00 O +ATOM 2315 N3 U B 72 17.011 6.773 -2.378 1.00 1.00 N +ATOM 2316 C4 U B 72 15.648 6.617 -2.197 1.00 1.00 C +ATOM 2317 O4 U B 72 14.972 6.004 -3.021 1.00 1.00 O +ATOM 2318 C5 U B 72 15.141 7.228 -0.988 1.00 1.00 C +ATOM 2319 C6 U B 72 15.969 7.885 -0.140 1.00 1.00 C +ATOM 2320 H5' U B 72 16.257 9.190 4.041 1.00 1.00 H +ATOM 2321 H5'' U B 72 16.139 10.935 3.743 1.00 1.00 H +ATOM 2322 H4' U B 72 18.325 10.105 3.043 1.00 1.00 H +ATOM 2323 H3' U B 72 16.468 10.978 0.825 1.00 1.00 H +ATOM 2324 H2' U B 72 18.026 10.350 -0.776 1.00 1.00 H +ATOM 2325 HO2' U B 72 19.838 10.937 1.257 1.00 1.00 H +ATOM 2326 H1' U B 72 19.179 8.203 0.549 1.00 1.00 H +ATOM 2327 H3 U B 72 17.412 6.362 -3.209 1.00 1.00 H +ATOM 2328 H5 U B 72 14.079 7.160 -0.757 1.00 1.00 H +ATOM 2329 H6 U B 72 15.561 8.336 0.764 1.00 1.00 H +ATOM 2330 P U B 73 17.680 13.453 0.804 1.00 1.00 P +ATOM 2331 OP1 U B 73 18.337 14.592 1.483 1.00 1.00 O +ATOM 2332 OP2 U B 73 16.219 13.473 0.576 1.00 1.00 O +ATOM 2333 O5' U B 73 18.410 13.230 -0.618 1.00 1.00 O +ATOM 2334 C5' U B 73 19.836 13.288 -0.726 1.00 1.00 C +ATOM 2335 C4' U B 73 20.289 13.325 -2.185 1.00 1.00 C +ATOM 2336 O4' U B 73 20.265 12.009 -2.732 1.00 1.00 O +ATOM 2337 C3' U B 73 19.418 14.179 -3.092 1.00 1.00 C +ATOM 2338 O3' U B 73 19.888 15.529 -3.103 1.00 1.00 O +ATOM 2339 C2' U B 73 19.626 13.538 -4.455 1.00 1.00 C +ATOM 2340 O2' U B 73 20.778 14.074 -5.117 1.00 1.00 O +ATOM 2341 C1' U B 73 19.824 12.065 -4.100 1.00 1.00 C +ATOM 2342 N1 U B 73 18.592 11.266 -4.189 1.00 1.00 N +ATOM 2343 C2 U B 73 18.405 10.500 -5.323 1.00 1.00 C +ATOM 2344 O2 U B 73 19.202 10.512 -6.260 1.00 1.00 O +ATOM 2345 N3 U B 73 17.264 9.719 -5.347 1.00 1.00 N +ATOM 2346 C4 U B 73 16.308 9.637 -4.349 1.00 1.00 C +ATOM 2347 O4 U B 73 15.331 8.903 -4.475 1.00 1.00 O +ATOM 2348 C5 U B 73 16.584 10.472 -3.201 1.00 1.00 C +ATOM 2349 C6 U B 73 17.695 11.246 -3.155 1.00 1.00 C +ATOM 2350 H5' U B 73 20.263 12.405 -0.248 1.00 1.00 H +ATOM 2351 H5'' U B 73 20.199 14.179 -0.217 1.00 1.00 H +ATOM 2352 H4' U B 73 21.312 13.695 -2.228 1.00 1.00 H +ATOM 2353 H3' U B 73 18.371 14.120 -2.792 1.00 1.00 H +ATOM 2354 H2' U B 73 18.729 13.662 -5.068 1.00 1.00 H +ATOM 2355 HO2' U B 73 20.759 13.759 -6.024 1.00 1.00 H +ATOM 2356 H1' U B 73 20.588 11.625 -4.742 1.00 1.00 H +ATOM 2357 H3 U B 73 17.115 9.152 -6.170 1.00 1.00 H +ATOM 2358 H5 U B 73 15.890 10.480 -2.362 1.00 1.00 H +ATOM 2359 H6 U B 73 17.877 11.868 -2.279 1.00 1.00 H +ATOM 2360 P C B 74 18.857 16.744 -3.343 1.00 1.00 P +ATOM 2361 OP1 C B 74 19.613 18.014 -3.249 1.00 1.00 O +ATOM 2362 OP2 C B 74 17.676 16.525 -2.479 1.00 1.00 O +ATOM 2363 O5' C B 74 18.406 16.538 -4.877 1.00 1.00 O +ATOM 2364 C5' C B 74 19.346 16.729 -5.936 1.00 1.00 C +ATOM 2365 C4' C B 74 18.910 16.034 -7.224 1.00 1.00 C +ATOM 2366 O4' C B 74 18.703 14.652 -6.979 1.00 1.00 O +ATOM 2367 C3' C B 74 17.608 16.531 -7.817 1.00 1.00 C +ATOM 2368 O3' C B 74 17.853 17.688 -8.624 1.00 1.00 O +ATOM 2369 C2' C B 74 17.196 15.355 -8.698 1.00 1.00 C +ATOM 2370 O2' C B 74 17.704 15.498 -10.028 1.00 1.00 O +ATOM 2371 C1' C B 74 17.816 14.143 -7.987 1.00 1.00 C +ATOM 2372 N1 C B 74 16.826 13.273 -7.313 1.00 1.00 N +ATOM 2373 C2 C B 74 16.443 12.116 -7.972 1.00 1.00 C +ATOM 2374 O2 C B 74 16.896 11.864 -9.086 1.00 1.00 O +ATOM 2375 N3 C B 74 15.559 11.283 -7.355 1.00 1.00 N +ATOM 2376 C4 C B 74 15.070 11.576 -6.141 1.00 1.00 C +ATOM 2377 N4 C B 74 14.207 10.738 -5.565 1.00 1.00 N +ATOM 2378 C5 C B 74 15.462 12.771 -5.458 1.00 1.00 C +ATOM 2379 C6 C B 74 16.337 13.587 -6.077 1.00 1.00 C +ATOM 2380 H5' C B 74 20.313 16.328 -5.627 1.00 1.00 H +ATOM 2381 H5'' C B 74 19.451 17.796 -6.128 1.00 1.00 H +ATOM 2382 H4' C B 74 19.699 16.134 -7.967 1.00 1.00 H +ATOM 2383 H3' C B 74 16.868 16.724 -7.037 1.00 1.00 H +ATOM 2384 H2' C B 74 16.115 15.257 -8.709 1.00 1.00 H +ATOM 2385 HO2' C B 74 17.150 16.142 -10.474 1.00 1.00 H +ATOM 2386 H1' C B 74 18.387 13.547 -8.701 1.00 1.00 H +ATOM 2387 H41 C B 74 13.933 9.901 -6.036 1.00 1.00 H +ATOM 2388 H42 C B 74 13.834 10.949 -4.650 1.00 1.00 H +ATOM 2389 H5 C B 74 15.067 13.011 -4.470 1.00 1.00 H +ATOM 2390 H6 C B 74 16.658 14.506 -5.587 1.00 1.00 H +ATOM 2391 P U B 75 16.970 19.023 -8.435 1.00 1.00 P +ATOM 2392 OP1 U B 75 17.804 20.180 -8.834 1.00 1.00 O +ATOM 2393 OP2 U B 75 16.365 18.989 -7.087 1.00 1.00 O +ATOM 2394 O5' U B 75 15.786 18.872 -9.522 1.00 1.00 O +ATOM 2395 C5' U B 75 16.076 18.416 -10.846 1.00 1.00 C +ATOM 2396 C4' U B 75 15.066 17.377 -11.337 1.00 1.00 C +ATOM 2397 O4' U B 75 15.097 16.222 -10.508 1.00 1.00 O +ATOM 2398 C3' U B 75 13.616 17.834 -11.344 1.00 1.00 C +ATOM 2399 O3' U B 75 13.318 18.500 -12.575 1.00 1.00 O +ATOM 2400 C2' U B 75 12.846 16.526 -11.277 1.00 1.00 C +ATOM 2401 O2' U B 75 12.463 16.076 -12.582 1.00 1.00 O +ATOM 2402 C1' U B 75 13.828 15.559 -10.617 1.00 1.00 C +ATOM 2403 N1 U B 75 13.412 15.108 -9.271 1.00 1.00 N +ATOM 2404 C2 U B 75 12.683 13.937 -9.203 1.00 1.00 C +ATOM 2405 O2 U B 75 12.375 13.298 -10.208 1.00 1.00 O +ATOM 2406 N3 U B 75 12.315 13.522 -7.936 1.00 1.00 N +ATOM 2407 C4 U B 75 12.610 14.169 -6.747 1.00 1.00 C +ATOM 2408 O4 U B 75 12.232 13.708 -5.672 1.00 1.00 O +ATOM 2409 C5 U B 75 13.375 15.385 -6.913 1.00 1.00 C +ATOM 2410 C6 U B 75 13.747 15.811 -8.145 1.00 1.00 C +ATOM 2411 H5' U B 75 17.073 17.971 -10.854 1.00 1.00 H +ATOM 2412 H5'' U B 75 16.064 19.267 -11.522 1.00 1.00 H +ATOM 2413 H4' U B 75 15.340 17.076 -12.346 1.00 1.00 H +ATOM 2414 H3' U B 75 13.398 18.465 -10.481 1.00 1.00 H +ATOM 2415 H2' U B 75 11.969 16.646 -10.641 1.00 1.00 H +ATOM 2416 HO2' U B 75 12.714 15.152 -12.651 1.00 1.00 H +ATOM 2417 H1' U B 75 13.947 14.687 -11.264 1.00 1.00 H +ATOM 2418 H3 U B 75 11.781 12.667 -7.870 1.00 1.00 H +ATOM 2419 H5 U B 75 13.657 15.967 -6.035 1.00 1.00 H +ATOM 2420 H6 U B 75 14.323 16.731 -8.241 1.00 1.00 H +ATOM 2421 P U B 76 12.106 19.561 -12.674 1.00 1.00 P +ATOM 2422 OP1 U B 76 12.146 20.174 -14.021 1.00 1.00 O +ATOM 2423 OP2 U B 76 12.149 20.423 -11.474 1.00 1.00 O +ATOM 2424 O5' U B 76 10.788 18.634 -12.584 1.00 1.00 O +ATOM 2425 C5' U B 76 10.439 17.759 -13.664 1.00 1.00 C +ATOM 2426 C4' U B 76 9.290 16.820 -13.292 1.00 1.00 C +ATOM 2427 O4' U B 76 9.662 16.010 -12.183 1.00 1.00 O +ATOM 2428 C3' U B 76 8.003 17.517 -12.886 1.00 1.00 C +ATOM 2429 O3' U B 76 7.194 17.746 -14.044 1.00 1.00 O +ATOM 2430 C2' U B 76 7.323 16.503 -11.976 1.00 1.00 C +ATOM 2431 O2' U B 76 6.376 15.709 -12.697 1.00 1.00 O +ATOM 2432 C1' U B 76 8.481 15.647 -11.451 1.00 1.00 C +ATOM 2433 N1 U B 76 8.769 15.844 -10.014 1.00 1.00 N +ATOM 2434 C2 U B 76 8.219 14.945 -9.120 1.00 1.00 C +ATOM 2435 O2 U B 76 7.509 14.010 -9.485 1.00 1.00 O +ATOM 2436 N3 U B 76 8.513 15.159 -7.786 1.00 1.00 N +ATOM 2437 C4 U B 76 9.300 16.179 -7.276 1.00 1.00 C +ATOM 2438 O4 U B 76 9.496 16.274 -6.066 1.00 1.00 O +ATOM 2439 C5 U B 76 9.833 17.070 -8.282 1.00 1.00 C +ATOM 2440 C6 U B 76 9.558 16.880 -9.595 1.00 1.00 C +ATOM 2441 H5' U B 76 11.311 17.165 -13.937 1.00 1.00 H +ATOM 2442 H5'' U B 76 10.139 18.362 -14.520 1.00 1.00 H +ATOM 2443 H4' U B 76 9.083 16.167 -14.138 1.00 1.00 H +ATOM 2444 H3' U B 76 8.212 18.446 -12.352 1.00 1.00 H +ATOM 2445 H2' U B 76 6.837 17.021 -11.143 1.00 1.00 H +ATOM 2446 HO2' U B 76 5.931 16.290 -13.318 1.00 1.00 H +ATOM 2447 H1' U B 76 8.257 14.596 -11.636 1.00 1.00 H +ATOM 2448 H3 U B 76 8.118 14.510 -7.120 1.00 1.00 H +ATOM 2449 H5 U B 76 10.464 17.905 -7.980 1.00 1.00 H +ATOM 2450 H6 U B 76 9.972 17.567 -10.333 1.00 1.00 H +ATOM 2451 P C B 77 5.973 18.794 -14.000 1.00 1.00 P +ATOM 2452 OP1 C B 77 5.338 18.820 -15.337 1.00 1.00 O +ATOM 2453 OP2 C B 77 6.461 20.051 -13.390 1.00 1.00 O +ATOM 2454 O5' C B 77 4.950 18.094 -12.970 1.00 1.00 O +ATOM 2455 C5' C B 77 4.160 18.884 -12.075 1.00 1.00 C +ATOM 2456 C4' C B 77 3.156 18.026 -11.307 1.00 1.00 C +ATOM 2457 O4' C B 77 3.845 16.991 -10.607 1.00 1.00 O +ATOM 2458 C3' C B 77 2.342 18.795 -10.275 1.00 1.00 C +ATOM 2459 O3' C B 77 1.087 19.189 -10.837 1.00 1.00 O +ATOM 2460 C2' C B 77 2.103 17.787 -9.162 1.00 1.00 C +ATOM 2461 O2' C B 77 0.819 17.166 -9.289 1.00 1.00 O +ATOM 2462 C1' C B 77 3.230 16.776 -9.329 1.00 1.00 C +ATOM 2463 N1 C B 77 4.280 16.897 -8.305 1.00 1.00 N +ATOM 2464 C2 C B 77 4.057 16.286 -7.081 1.00 1.00 C +ATOM 2465 O2 C B 77 3.009 15.678 -6.879 1.00 1.00 O +ATOM 2466 N3 C B 77 5.022 16.383 -6.126 1.00 1.00 N +ATOM 2467 C4 C B 77 6.159 17.051 -6.361 1.00 1.00 C +ATOM 2468 N4 C B 77 7.084 17.124 -5.405 1.00 1.00 N +ATOM 2469 C5 C B 77 6.393 17.686 -7.623 1.00 1.00 C +ATOM 2470 C6 C B 77 5.432 17.584 -8.561 1.00 1.00 C +ATOM 2471 H5' C B 77 3.620 19.637 -12.649 1.00 1.00 H +ATOM 2472 H5'' C B 77 4.819 19.383 -11.365 1.00 1.00 H +ATOM 2473 H4' C B 77 2.474 17.563 -12.018 1.00 1.00 H +ATOM 2474 H3' C B 77 2.900 19.657 -9.904 1.00 1.00 H +ATOM 2475 H2' C B 77 2.197 18.280 -8.195 1.00 1.00 H +ATOM 2476 HO2' C B 77 0.957 16.218 -9.247 1.00 1.00 H +ATOM 2477 H1' C B 77 2.817 15.769 -9.295 1.00 1.00 H +ATOM 2478 H41 C B 77 6.921 16.677 -4.513 1.00 1.00 H +ATOM 2479 H42 C B 77 7.945 17.626 -5.571 1.00 1.00 H +ATOM 2480 H5 C B 77 7.316 18.231 -7.817 1.00 1.00 H +ATOM 2481 H6 C B 77 5.575 18.054 -9.535 1.00 1.00 H +ATOM 2482 P C B 78 0.224 20.366 -10.156 1.00 1.00 P +ATOM 2483 OP1 C B 78 -0.916 20.679 -11.048 1.00 1.00 O +ATOM 2484 OP2 C B 78 1.153 21.442 -9.745 1.00 1.00 O +ATOM 2485 O5' C B 78 -0.358 19.667 -8.825 1.00 1.00 O +ATOM 2486 C5' C B 78 -1.314 18.605 -8.914 1.00 1.00 C +ATOM 2487 C4' C B 78 -1.753 18.119 -7.531 1.00 1.00 C +ATOM 2488 O4' C B 78 -0.667 17.489 -6.862 1.00 1.00 O +ATOM 2489 C3' C B 78 -2.241 19.215 -6.605 1.00 1.00 C +ATOM 2490 O3' C B 78 -3.650 19.401 -6.776 1.00 1.00 O +ATOM 2491 C2' C B 78 -1.953 18.665 -5.212 1.00 1.00 C +ATOM 2492 O2' C B 78 -3.116 18.052 -4.644 1.00 1.00 O +ATOM 2493 C1' C B 78 -0.837 17.644 -5.443 1.00 1.00 C +ATOM 2494 N1 C B 78 0.471 18.041 -4.875 1.00 1.00 N +ATOM 2495 C2 C B 78 0.808 17.544 -3.627 1.00 1.00 C +ATOM 2496 O2 C B 78 0.025 16.813 -3.023 1.00 1.00 O +ATOM 2497 N3 C B 78 2.015 17.888 -3.099 1.00 1.00 N +ATOM 2498 C4 C B 78 2.857 18.686 -3.770 1.00 1.00 C +ATOM 2499 N4 C B 78 4.031 19.004 -3.225 1.00 1.00 N +ATOM 2500 C5 C B 78 2.512 19.201 -5.059 1.00 1.00 C +ATOM 2501 C6 C B 78 1.316 18.855 -5.572 1.00 1.00 C +ATOM 2502 H5' C B 78 -0.872 17.770 -9.460 1.00 1.00 H +ATOM 2503 H5'' C B 78 -2.189 18.960 -9.457 1.00 1.00 H +ATOM 2504 H4' C B 78 -2.548 17.385 -7.654 1.00 1.00 H +ATOM 2505 H3' C B 78 -1.693 20.143 -6.780 1.00 1.00 H +ATOM 2506 H2' C B 78 -1.591 19.470 -4.568 1.00 1.00 H +ATOM 2507 HO2' C B 78 -3.446 17.414 -5.282 1.00 1.00 H +ATOM 2508 H1' C B 78 -1.138 16.686 -5.016 1.00 1.00 H +ATOM 2509 H41 C B 78 4.279 18.645 -2.319 1.00 1.00 H +ATOM 2510 H42 C B 78 4.671 19.605 -3.723 1.00 1.00 H +ATOM 2511 H5 C B 78 3.193 19.852 -5.607 1.00 1.00 H +ATOM 2512 H6 C B 78 1.018 19.231 -6.552 1.00 1.00 H +ATOM 2513 P U B 79 -4.352 20.750 -6.261 1.00 1.00 P +ATOM 2514 OP1 U B 79 -5.791 20.476 -6.052 1.00 1.00 O +ATOM 2515 OP2 U B 79 -3.930 21.860 -7.145 1.00 1.00 O +ATOM 2516 O5' U B 79 -3.659 20.953 -4.824 1.00 1.00 O +ATOM 2517 C5' U B 79 -4.294 21.714 -3.798 1.00 1.00 C +ATOM 2518 C4' U B 79 -4.188 21.010 -2.446 1.00 1.00 C +ATOM 2519 O4' U B 79 -2.956 20.299 -2.367 1.00 1.00 O +ATOM 2520 C3' U B 79 -4.238 21.943 -1.247 1.00 1.00 C +ATOM 2521 O3' U B 79 -5.587 22.041 -0.780 1.00 1.00 O +ATOM 2522 C2' U B 79 -3.376 21.248 -0.201 1.00 1.00 C +ATOM 2523 O2' U B 79 -4.180 20.531 0.739 1.00 1.00 O +ATOM 2524 C1' U B 79 -2.490 20.300 -1.012 1.00 1.00 C +ATOM 2525 N1 U B 79 -1.067 20.685 -1.033 1.00 1.00 N +ATOM 2526 C2 U B 79 -0.362 20.583 0.151 1.00 1.00 C +ATOM 2527 O2 U B 79 -0.886 20.188 1.191 1.00 1.00 O +ATOM 2528 N3 U B 79 0.969 20.953 0.099 1.00 1.00 N +ATOM 2529 C4 U B 79 1.647 21.409 -1.018 1.00 1.00 C +ATOM 2530 O4 U B 79 2.837 21.709 -0.950 1.00 1.00 O +ATOM 2531 C5 U B 79 0.832 21.486 -2.210 1.00 1.00 C +ATOM 2532 C6 U B 79 -0.474 21.129 -2.184 1.00 1.00 C +ATOM 2533 H5' U B 79 -5.346 21.847 -4.050 1.00 1.00 H +ATOM 2534 H5'' U B 79 -3.816 22.691 -3.735 1.00 1.00 H +ATOM 2535 H4' U B 79 -5.001 20.291 -2.363 1.00 1.00 H +ATOM 2536 H3' U B 79 -3.831 22.925 -1.494 1.00 1.00 H +ATOM 2537 H2' U B 79 -2.753 21.987 0.312 1.00 1.00 H +ATOM 2538 HO2' U B 79 -3.583 20.059 1.324 1.00 1.00 H +ATOM 2539 H1' U B 79 -2.578 19.293 -0.603 1.00 1.00 H +ATOM 2540 H3 U B 79 1.497 20.882 0.957 1.00 1.00 H +ATOM 2541 H5 U B 79 1.276 21.834 -3.143 1.00 1.00 H +ATOM 2542 H6 U B 79 -1.065 21.197 -3.098 1.00 1.00 H +ATOM 2543 P A B 80 -6.111 23.380 -0.057 1.00 1.00 P +ATOM 2544 OP1 A B 80 -7.556 23.220 0.221 1.00 1.00 O +ATOM 2545 OP2 A B 80 -5.632 24.544 -0.837 1.00 1.00 O +ATOM 2546 O5' A B 80 -5.320 23.352 1.344 1.00 1.00 O +ATOM 2547 C5' A B 80 -5.463 22.244 2.235 1.00 1.00 C +ATOM 2548 C4' A B 80 -4.734 22.487 3.552 1.00 1.00 C +ATOM 2549 O4' A B 80 -3.321 22.459 3.325 1.00 1.00 O +ATOM 2550 C3' A B 80 -5.075 23.823 4.203 1.00 1.00 C +ATOM 2551 O3' A B 80 -5.201 23.647 5.618 1.00 1.00 O +ATOM 2552 C2' A B 80 -3.875 24.708 3.901 1.00 1.00 C +ATOM 2553 O2' A B 80 -3.596 25.597 4.989 1.00 1.00 O +ATOM 2554 C1' A B 80 -2.741 23.713 3.693 1.00 1.00 C +ATOM 2555 N9 A B 80 -1.798 24.097 2.626 1.00 1.00 N +ATOM 2556 C8 A B 80 -2.071 24.522 1.350 1.00 1.00 C +ATOM 2557 N7 A B 80 -1.007 24.794 0.646 1.00 1.00 N +ATOM 2558 C5 A B 80 0.046 24.530 1.517 1.00 1.00 C +ATOM 2559 C6 A B 80 1.441 24.620 1.374 1.00 1.00 C +ATOM 2560 N6 A B 80 2.035 25.019 0.249 1.00 1.00 N +ATOM 2561 N1 A B 80 2.192 24.283 2.437 1.00 1.00 N +ATOM 2562 C2 A B 80 1.593 23.886 3.553 1.00 1.00 C +ATOM 2563 N3 A B 80 0.300 23.759 3.810 1.00 1.00 N +ATOM 2564 C4 A B 80 -0.427 24.105 2.726 1.00 1.00 C +ATOM 2565 H5' A B 80 -5.056 21.351 1.761 1.00 1.00 H +ATOM 2566 H5'' A B 80 -6.523 22.087 2.438 1.00 1.00 H +ATOM 2567 H4' A B 80 -4.986 21.685 4.244 1.00 1.00 H +ATOM 2568 H3' A B 80 -5.986 24.245 3.775 1.00 1.00 H +ATOM 2569 H2' A B 80 -4.051 25.270 2.979 1.00 1.00 H +ATOM 2570 HO2' A B 80 -3.231 26.402 4.614 1.00 1.00 H +ATOM 2571 H1' A B 80 -2.192 23.596 4.626 1.00 1.00 H +ATOM 2572 H8 A B 80 -3.083 24.624 0.961 1.00 1.00 H +ATOM 2573 H61 A B 80 3.043 25.066 0.200 1.00 1.00 H +ATOM 2574 H62 A B 80 1.478 25.273 -0.554 1.00 1.00 H +ATOM 2575 H2 A B 80 2.262 23.627 4.375 1.00 1.00 H +ATOM 2576 P A B 81 -6.162 24.612 6.478 1.00 1.00 P +ATOM 2577 OP1 A B 81 -7.537 24.493 5.940 1.00 1.00 O +ATOM 2578 OP2 A B 81 -5.521 25.942 6.574 1.00 1.00 O +ATOM 2579 O5' A B 81 -6.134 23.930 7.938 1.00 1.00 O +ATOM 2580 C5' A B 81 -5.358 24.506 8.992 1.00 1.00 C +ATOM 2581 C4' A B 81 -5.003 23.472 10.061 1.00 1.00 C +ATOM 2582 O4' A B 81 -4.744 22.211 9.436 1.00 1.00 O +ATOM 2583 C3' A B 81 -3.777 23.836 10.903 1.00 1.00 C +ATOM 2584 O3' A B 81 -4.201 24.296 12.191 1.00 1.00 O +ATOM 2585 C2' A B 81 -3.025 22.523 11.047 1.00 1.00 C +ATOM 2586 O2' A B 81 -3.403 21.831 12.243 1.00 1.00 O +ATOM 2587 C1' A B 81 -3.444 21.751 9.804 1.00 1.00 C +ATOM 2588 N9 A B 81 -2.562 21.954 8.643 1.00 1.00 N +ATOM 2589 C8 A B 81 -2.845 22.561 7.447 1.00 1.00 C +ATOM 2590 N7 A B 81 -1.840 22.583 6.615 1.00 1.00 N +ATOM 2591 C5 A B 81 -0.818 21.946 7.311 1.00 1.00 C +ATOM 2592 C6 A B 81 0.513 21.647 6.979 1.00 1.00 C +ATOM 2593 N6 A B 81 1.063 21.968 5.807 1.00 1.00 N +ATOM 2594 N1 A B 81 1.250 21.006 7.902 1.00 1.00 N +ATOM 2595 C2 A B 81 0.697 20.690 9.067 1.00 1.00 C +ATOM 2596 N3 A B 81 -0.536 20.917 9.496 1.00 1.00 N +ATOM 2597 C4 A B 81 -1.250 21.560 8.548 1.00 1.00 C +ATOM 2598 H5' A B 81 -5.927 25.314 9.453 1.00 1.00 H +ATOM 2599 H5'' A B 81 -4.440 24.914 8.570 1.00 1.00 H +ATOM 2600 H4' A B 81 -5.859 23.354 10.725 1.00 1.00 H +ATOM 2601 H3' A B 81 -3.160 24.582 10.399 1.00 1.00 H +ATOM 2602 H2' A B 81 -1.948 22.706 11.028 1.00 1.00 H +ATOM 2603 HO2' A B 81 -3.523 20.908 12.013 1.00 1.00 H +ATOM 2604 H1' A B 81 -3.490 20.688 10.039 1.00 1.00 H +ATOM 2605 H8 A B 81 -3.822 22.984 7.210 1.00 1.00 H +ATOM 2606 H61 A B 81 2.025 21.729 5.618 1.00 1.00 H +ATOM 2607 H62 A B 81 0.515 22.449 5.108 1.00 1.00 H +ATOM 2608 H2 A B 81 1.350 20.171 9.770 1.00 1.00 H +ATOM 2609 P G B 82 -3.418 25.491 12.938 1.00 1.00 P +ATOM 2610 OP1 G B 82 -4.183 25.855 14.151 1.00 1.00 O +ATOM 2611 OP2 G B 82 -3.093 26.530 11.934 1.00 1.00 O +ATOM 2612 O5' G B 82 -2.042 24.789 13.400 1.00 1.00 O +ATOM 2613 C5' G B 82 -2.018 23.920 14.537 1.00 1.00 C +ATOM 2614 C4' G B 82 -0.826 22.964 14.495 1.00 1.00 C +ATOM 2615 O4' G B 82 -0.702 22.415 13.179 1.00 1.00 O +ATOM 2616 C3' G B 82 0.511 23.613 14.846 1.00 1.00 C +ATOM 2617 O3' G B 82 0.831 23.341 16.216 1.00 1.00 O +ATOM 2618 C2' G B 82 1.502 22.907 13.936 1.00 1.00 C +ATOM 2619 O2' G B 82 2.060 21.748 14.565 1.00 1.00 O +ATOM 2620 C1' G B 82 0.654 22.532 12.733 1.00 1.00 C +ATOM 2621 N9 G B 82 0.682 23.533 11.651 1.00 1.00 N +ATOM 2622 C8 G B 82 -0.196 24.558 11.413 1.00 1.00 C +ATOM 2623 N7 G B 82 0.099 25.275 10.365 1.00 1.00 N +ATOM 2624 C5 G B 82 1.258 24.683 9.870 1.00 1.00 C +ATOM 2625 C6 G B 82 2.046 25.029 8.738 1.00 1.00 C +ATOM 2626 O6 G B 82 1.870 25.945 7.937 1.00 1.00 O +ATOM 2627 N1 G B 82 3.131 24.175 8.592 1.00 1.00 N +ATOM 2628 C2 G B 82 3.424 23.120 9.428 1.00 1.00 C +ATOM 2629 N2 G B 82 4.511 22.411 9.125 1.00 1.00 N +ATOM 2630 N3 G B 82 2.686 22.792 10.494 1.00 1.00 N +ATOM 2631 C4 G B 82 1.621 23.615 10.652 1.00 1.00 C +ATOM 2632 H5' G B 82 -2.939 23.337 14.558 1.00 1.00 H +ATOM 2633 H5'' G B 82 -1.958 24.522 15.442 1.00 1.00 H +ATOM 2634 H4' G B 82 -1.010 22.146 15.190 1.00 1.00 H +ATOM 2635 H3' G B 82 0.490 24.685 14.645 1.00 1.00 H +ATOM 2636 H2' G B 82 2.289 23.598 13.633 1.00 1.00 H +ATOM 2637 HO2' G B 82 2.916 21.589 14.162 1.00 1.00 H +ATOM 2638 H1' G B 82 0.989 21.573 12.340 1.00 1.00 H +ATOM 2639 H8 G B 82 -1.065 24.756 12.041 1.00 1.00 H +ATOM 2640 H1 G B 82 3.739 24.359 7.807 1.00 1.00 H +ATOM 2641 H21 G B 82 5.068 22.660 8.321 1.00 1.00 H +ATOM 2642 H22 G B 82 4.777 21.625 9.701 1.00 1.00 H +ATOM 2643 P U B 83 1.618 24.426 17.113 1.00 1.00 P +ATOM 2644 OP1 U B 83 1.705 23.906 18.495 1.00 1.00 O +ATOM 2645 OP2 U B 83 1.015 25.755 16.862 1.00 1.00 O +ATOM 2646 O5' U B 83 3.099 24.417 16.477 1.00 1.00 O +ATOM 2647 C5' U B 83 4.006 23.347 16.762 1.00 1.00 C +ATOM 2648 C4' U B 83 5.336 23.526 16.033 1.00 1.00 C +ATOM 2649 O4' U B 83 5.113 23.471 14.621 1.00 1.00 O +ATOM 2650 C3' U B 83 6.041 24.846 16.325 1.00 1.00 C +ATOM 2651 O3' U B 83 7.006 24.660 17.368 1.00 1.00 O +ATOM 2652 C2' U B 83 6.752 25.160 15.018 1.00 1.00 C +ATOM 2653 O2' U B 83 8.068 24.598 14.993 1.00 1.00 O +ATOM 2654 C1' U B 83 5.852 24.514 13.972 1.00 1.00 C +ATOM 2655 N1 U B 83 4.873 25.444 13.369 1.00 1.00 N +ATOM 2656 C2 U B 83 5.207 26.033 12.164 1.00 1.00 C +ATOM 2657 O2 U B 83 6.276 25.807 11.599 1.00 1.00 O +ATOM 2658 N3 U B 83 4.269 26.896 11.628 1.00 1.00 N +ATOM 2659 C4 U B 83 3.042 27.218 12.186 1.00 1.00 C +ATOM 2660 O4 U B 83 2.282 28.001 11.619 1.00 1.00 O +ATOM 2661 C5 U B 83 2.776 26.556 13.444 1.00 1.00 C +ATOM 2662 C6 U B 83 3.681 25.706 13.987 1.00 1.00 C +ATOM 2663 H5' U B 83 3.554 22.407 16.449 1.00 1.00 H +ATOM 2664 H5'' U B 83 4.190 23.314 17.835 1.00 1.00 H +ATOM 2665 H4' U B 83 5.999 22.707 16.306 1.00 1.00 H +ATOM 2666 H3' U B 83 5.321 25.627 16.577 1.00 1.00 H +ATOM 2667 H2' U B 83 6.790 26.239 14.861 1.00 1.00 H +ATOM 2668 HO2' U B 83 8.301 24.376 15.897 1.00 1.00 H +ATOM 2669 H1' U B 83 6.470 24.080 13.185 1.00 1.00 H +ATOM 2670 H3 U B 83 4.500 27.334 10.748 1.00 1.00 H +ATOM 2671 H5 U B 83 1.837 26.745 13.962 1.00 1.00 H +ATOM 2672 H6 U B 83 3.454 25.222 14.937 1.00 1.00 H +ATOM 2673 P C B 84 7.098 25.692 18.603 1.00 1.00 P +ATOM 2674 OP1 C B 84 8.108 25.176 19.556 1.00 1.00 O +ATOM 2675 OP2 C B 84 5.725 25.980 19.071 1.00 1.00 O +ATOM 2676 O5' C B 84 7.691 27.027 17.923 1.00 1.00 O +ATOM 2677 C5' C B 84 9.059 27.083 17.506 1.00 1.00 C +ATOM 2678 C4' C B 84 9.326 28.282 16.601 1.00 1.00 C +ATOM 2679 O4' C B 84 8.573 28.155 15.399 1.00 1.00 O +ATOM 2680 C3' C B 84 8.949 29.628 17.197 1.00 1.00 C +ATOM 2681 O3' C B 84 10.065 30.184 17.904 1.00 1.00 O +ATOM 2682 C2' C B 84 8.642 30.482 15.978 1.00 1.00 C +ATOM 2683 O2' C B 84 9.773 31.276 15.599 1.00 1.00 O +ATOM 2684 C1' C B 84 8.284 29.465 14.894 1.00 1.00 C +ATOM 2685 N1 C B 84 6.863 29.498 14.494 1.00 1.00 N +ATOM 2686 C2 C B 84 6.530 30.317 13.426 1.00 1.00 C +ATOM 2687 O2 C B 84 7.399 30.982 12.866 1.00 1.00 O +ATOM 2688 N3 C B 84 5.229 30.359 13.026 1.00 1.00 N +ATOM 2689 C4 C B 84 4.294 29.629 13.649 1.00 1.00 C +ATOM 2690 N4 C B 84 3.029 29.692 13.232 1.00 1.00 N +ATOM 2691 C5 C B 84 4.634 28.783 14.752 1.00 1.00 C +ATOM 2692 C6 C B 84 5.924 28.748 15.140 1.00 1.00 C +ATOM 2693 H5' C B 84 9.304 26.168 16.965 1.00 1.00 H +ATOM 2694 H5'' C B 84 9.696 27.156 18.387 1.00 1.00 H +ATOM 2695 H4' C B 84 10.383 28.296 16.339 1.00 1.00 H +ATOM 2696 H3' C B 84 8.072 29.538 17.841 1.00 1.00 H +ATOM 2697 H2' C B 84 7.779 31.116 16.184 1.00 1.00 H +ATOM 2698 HO2' C B 84 9.703 31.442 14.657 1.00 1.00 H +ATOM 2699 H1' C B 84 8.906 29.647 14.016 1.00 1.00 H +ATOM 2700 H41 C B 84 2.783 30.285 12.456 1.00 1.00 H +ATOM 2701 H42 C B 84 2.318 29.146 13.695 1.00 1.00 H +ATOM 2702 H5 C B 84 3.875 28.187 15.260 1.00 1.00 H +ATOM 2703 H6 C B 84 6.219 28.116 15.977 1.00 1.00 H +ATOM 2704 P C B 85 9.875 31.470 18.858 1.00 1.00 P +ATOM 2705 OP1 C B 85 10.920 31.425 19.906 1.00 1.00 O +ATOM 2706 OP2 C B 85 8.449 31.554 19.243 1.00 1.00 O +ATOM 2707 O5' C B 85 10.205 32.703 17.870 1.00 1.00 O +ATOM 2708 C5' C B 85 11.529 32.897 17.359 1.00 1.00 C +ATOM 2709 C4' C B 85 11.550 33.890 16.195 1.00 1.00 C +ATOM 2710 O4' C B 85 10.647 33.458 15.174 1.00 1.00 O +ATOM 2711 C3' C B 85 11.141 35.309 16.568 1.00 1.00 C +ATOM 2712 O3' C B 85 12.302 36.079 16.902 1.00 1.00 O +ATOM 2713 C2' C B 85 10.527 35.846 15.287 1.00 1.00 C +ATOM 2714 O2' C B 85 11.511 36.480 14.462 1.00 1.00 O +ATOM 2715 C1' C B 85 9.964 34.595 14.620 1.00 1.00 C +ATOM 2716 N1 C B 85 8.519 34.398 14.847 1.00 1.00 N +ATOM 2717 C2 C B 85 7.640 34.996 13.957 1.00 1.00 C +ATOM 2718 O2 C B 85 8.072 35.664 13.021 1.00 1.00 O +ATOM 2719 N3 C B 85 6.303 34.822 14.155 1.00 1.00 N +ATOM 2720 C4 C B 85 5.850 34.090 15.183 1.00 1.00 C +ATOM 2721 N4 C B 85 4.535 33.939 15.349 1.00 1.00 N +ATOM 2722 C5 C B 85 6.754 33.472 16.102 1.00 1.00 C +ATOM 2723 C6 C B 85 8.073 33.650 15.898 1.00 1.00 C +ATOM 2724 H5' C B 85 11.921 31.940 17.016 1.00 1.00 H +ATOM 2725 H5'' C B 85 12.166 33.275 18.158 1.00 1.00 H +ATOM 2726 H4' C B 85 12.553 33.914 15.774 1.00 1.00 H +ATOM 2727 H3' C B 85 10.414 35.307 17.381 1.00 1.00 H +ATOM 2728 H2' C B 85 9.717 36.537 15.523 1.00 1.00 H +ATOM 2729 HO2' C B 85 12.363 36.347 14.881 1.00 1.00 H +ATOM 2730 H1' C B 85 10.155 34.642 13.549 1.00 1.00 H +ATOM 2731 H41 C B 85 3.894 34.373 14.704 1.00 1.00 H +ATOM 2732 H42 C B 85 4.183 33.391 16.120 1.00 1.00 H +ATOM 2733 H5 C B 85 6.388 32.876 16.939 1.00 1.00 H +ATOM 2734 H6 C B 85 8.792 33.193 16.578 1.00 1.00 H +ATOM 2735 P U B 86 12.181 37.374 17.853 1.00 1.00 P +ATOM 2736 OP1 U B 86 13.494 38.057 17.871 1.00 1.00 O +ATOM 2737 OP2 U B 86 11.550 36.956 19.126 1.00 1.00 O +ATOM 2738 O5' U B 86 11.139 38.312 17.054 1.00 1.00 O +ATOM 2739 C5' U B 86 11.497 38.888 15.795 1.00 1.00 C +ATOM 2740 C4' U B 86 10.318 39.608 15.140 1.00 1.00 C +ATOM 2741 O4' U B 86 9.230 38.709 14.980 1.00 1.00 O +ATOM 2742 C3' U B 86 9.787 40.791 15.937 1.00 1.00 C +ATOM 2743 O3' U B 86 10.401 42.015 15.518 1.00 1.00 O +ATOM 2744 C2' U B 86 8.285 40.798 15.638 1.00 1.00 C +ATOM 2745 O2' U B 86 7.928 41.908 14.809 1.00 1.00 O +ATOM 2746 C1' U B 86 8.025 39.473 14.925 1.00 1.00 C +ATOM 2747 N1 U B 86 6.947 38.673 15.540 1.00 1.00 N +ATOM 2748 C2 U B 86 5.660 38.882 15.086 1.00 1.00 C +ATOM 2749 O2 U B 86 5.401 39.703 14.210 1.00 1.00 O +ATOM 2750 N3 U B 86 4.674 38.113 15.678 1.00 1.00 N +ATOM 2751 C4 U B 86 4.863 37.168 16.672 1.00 1.00 C +ATOM 2752 O4 U B 86 3.910 36.538 17.128 1.00 1.00 O +ATOM 2753 C5 U B 86 6.240 37.016 17.087 1.00 1.00 C +ATOM 2754 C6 U B 86 7.223 37.758 16.520 1.00 1.00 C +ATOM 2755 H5' U B 86 11.845 38.097 15.129 1.00 1.00 H +ATOM 2756 H5'' U B 86 12.306 39.602 15.949 1.00 1.00 H +ATOM 2757 H4' U B 86 10.623 39.955 14.155 1.00 1.00 H +ATOM 2758 H3' U B 86 9.954 40.624 17.004 1.00 1.00 H +ATOM 2759 HO3' U B 86 10.435 42.595 16.282 1.00 1.00 H +ATOM 2760 H2' U B 86 7.722 40.823 16.572 1.00 1.00 H +ATOM 2761 HO2' U B 86 7.578 41.550 13.989 1.00 1.00 H +ATOM 2762 H1' U B 86 7.775 39.671 13.883 1.00 1.00 H +ATOM 2763 H3 U B 86 3.727 38.255 15.357 1.00 1.00 H +ATOM 2764 H5 U B 86 6.490 36.297 17.866 1.00 1.00 H +ATOM 2765 H6 U B 86 8.252 37.624 16.852 1.00 1.00 H +TER 2766 U B 86 +ENDMDL +MODEL 5 +ATOM 1 O5' G A 1 6.977 -36.026 8.499 1.00 1.00 O +ATOM 2 C5' G A 1 8.116 -36.214 7.655 1.00 1.00 C +ATOM 3 C4' G A 1 7.740 -36.947 6.368 1.00 1.00 C +ATOM 4 O4' G A 1 7.411 -38.309 6.668 1.00 1.00 O +ATOM 5 C3' G A 1 6.546 -36.337 5.636 1.00 1.00 C +ATOM 6 O3' G A 1 7.008 -35.538 4.542 1.00 1.00 O +ATOM 7 C2' G A 1 5.795 -37.547 5.107 1.00 1.00 C +ATOM 8 O2' G A 1 6.256 -37.922 3.804 1.00 1.00 O +ATOM 9 C1' G A 1 6.117 -38.614 6.138 1.00 1.00 C +ATOM 10 N9 G A 1 5.179 -38.658 7.270 1.00 1.00 N +ATOM 11 C8 G A 1 5.398 -38.293 8.573 1.00 1.00 C +ATOM 12 N7 G A 1 4.363 -38.457 9.349 1.00 1.00 N +ATOM 13 C5 G A 1 3.385 -38.967 8.501 1.00 1.00 C +ATOM 14 C6 G A 1 2.042 -39.342 8.780 1.00 1.00 C +ATOM 15 O6 G A 1 1.445 -39.296 9.853 1.00 1.00 O +ATOM 16 N1 G A 1 1.397 -39.809 7.644 1.00 1.00 N +ATOM 17 C2 G A 1 1.969 -39.904 6.392 1.00 1.00 C +ATOM 18 N2 G A 1 1.189 -40.379 5.420 1.00 1.00 N +ATOM 19 N3 G A 1 3.230 -39.552 6.127 1.00 1.00 N +ATOM 20 C4 G A 1 3.876 -39.093 7.225 1.00 1.00 C +ATOM 21 H5' G A 1 8.867 -36.791 8.199 1.00 1.00 H +ATOM 22 H5'' G A 1 8.535 -35.245 7.397 1.00 1.00 H +ATOM 23 H4' G A 1 8.599 -36.943 5.701 1.00 1.00 H +ATOM 24 H3' G A 1 5.923 -35.758 6.320 1.00 1.00 H +ATOM 25 H2' G A 1 4.722 -37.349 5.097 1.00 1.00 H +ATOM 26 HO2' G A 1 5.796 -38.727 3.560 1.00 1.00 H +ATOM 27 H1' G A 1 6.143 -39.590 5.654 1.00 1.00 H +ATOM 28 H8 G A 1 6.351 -37.901 8.929 1.00 1.00 H +ATOM 29 H1 G A 1 0.436 -40.096 7.764 1.00 1.00 H +ATOM 30 H21 G A 1 0.236 -40.645 5.621 1.00 1.00 H +ATOM 31 H22 G A 1 1.552 -40.471 4.482 1.00 1.00 H +ATOM 32 HO5' G A 1 6.786 -35.085 8.513 1.00 1.00 H +ATOM 33 P G A 2 6.166 -34.255 4.050 1.00 1.00 P +ATOM 34 OP1 G A 2 6.872 -33.655 2.896 1.00 1.00 O +ATOM 35 OP2 G A 2 5.850 -33.425 5.234 1.00 1.00 O +ATOM 36 O5' G A 2 4.797 -34.910 3.516 1.00 1.00 O +ATOM 37 C5' G A 2 4.818 -35.926 2.513 1.00 1.00 C +ATOM 38 C4' G A 2 3.510 -36.712 2.488 1.00 1.00 C +ATOM 39 O4' G A 2 3.243 -37.276 3.769 1.00 1.00 O +ATOM 40 C3' G A 2 2.287 -35.884 2.128 1.00 1.00 C +ATOM 41 O3' G A 2 2.111 -35.881 0.705 1.00 1.00 O +ATOM 42 C2' G A 2 1.146 -36.640 2.789 1.00 1.00 C +ATOM 43 O2' G A 2 0.484 -37.505 1.858 1.00 1.00 O +ATOM 44 C1' G A 2 1.824 -37.434 3.906 1.00 1.00 C +ATOM 45 N9 G A 2 1.423 -37.013 5.261 1.00 1.00 N +ATOM 46 C8 G A 2 2.148 -36.358 6.223 1.00 1.00 C +ATOM 47 N7 G A 2 1.490 -36.153 7.331 1.00 1.00 N +ATOM 48 C5 G A 2 0.239 -36.712 7.087 1.00 1.00 C +ATOM 49 C6 G A 2 -0.904 -36.795 7.930 1.00 1.00 C +ATOM 50 O6 G A 2 -1.037 -36.381 9.080 1.00 1.00 O +ATOM 51 N1 G A 2 -1.960 -37.438 7.296 1.00 1.00 N +ATOM 52 C2 G A 2 -1.923 -37.941 6.013 1.00 1.00 C +ATOM 53 N2 G A 2 -3.037 -38.527 5.575 1.00 1.00 N +ATOM 54 N3 G A 2 -0.850 -37.866 5.220 1.00 1.00 N +ATOM 55 C4 G A 2 0.190 -37.242 5.821 1.00 1.00 C +ATOM 56 H5' G A 2 5.641 -36.611 2.716 1.00 1.00 H +ATOM 57 H5'' G A 2 4.973 -35.463 1.540 1.00 1.00 H +ATOM 58 H4' G A 2 3.605 -37.525 1.771 1.00 1.00 H +ATOM 59 H3' G A 2 2.368 -34.870 2.525 1.00 1.00 H +ATOM 60 H2' G A 2 0.440 -35.933 3.226 1.00 1.00 H +ATOM 61 HO2' G A 2 0.333 -38.341 2.304 1.00 1.00 H +ATOM 62 H1' G A 2 1.576 -38.487 3.784 1.00 1.00 H +ATOM 63 H8 G A 2 3.179 -36.036 6.076 1.00 1.00 H +ATOM 64 H1 G A 2 -2.809 -37.534 7.834 1.00 1.00 H +ATOM 65 H21 G A 2 -3.845 -38.583 6.174 1.00 1.00 H +ATOM 66 H22 G A 2 -3.070 -38.914 4.644 1.00 1.00 H +ATOM 67 P G A 3 1.253 -34.729 -0.026 1.00 1.00 P +ATOM 68 OP1 G A 3 1.665 -34.679 -1.447 1.00 1.00 O +ATOM 69 OP2 G A 3 1.316 -33.506 0.803 1.00 1.00 O +ATOM 70 O5' G A 3 -0.253 -35.307 0.039 1.00 1.00 O +ATOM 71 C5' G A 3 -0.601 -36.519 -0.637 1.00 1.00 C +ATOM 72 C4' G A 3 -2.034 -36.951 -0.326 1.00 1.00 C +ATOM 73 O4' G A 3 -2.149 -37.257 1.065 1.00 1.00 O +ATOM 74 C3' G A 3 -3.087 -35.897 -0.646 1.00 1.00 C +ATOM 75 O3' G A 3 -3.637 -36.150 -1.943 1.00 1.00 O +ATOM 76 C2' G A 3 -4.150 -36.118 0.418 1.00 1.00 C +ATOM 77 O2' G A 3 -5.154 -37.035 -0.029 1.00 1.00 O +ATOM 78 C1' G A 3 -3.357 -36.688 1.587 1.00 1.00 C +ATOM 79 N9 G A 3 -2.975 -35.680 2.590 1.00 1.00 N +ATOM 80 C8 G A 3 -1.844 -34.907 2.644 1.00 1.00 C +ATOM 81 N7 G A 3 -1.792 -34.118 3.680 1.00 1.00 N +ATOM 82 C5 G A 3 -2.973 -34.384 4.364 1.00 1.00 C +ATOM 83 C6 G A 3 -3.472 -33.823 5.573 1.00 1.00 C +ATOM 84 O6 G A 3 -2.955 -32.968 6.289 1.00 1.00 O +ATOM 85 N1 G A 3 -4.703 -34.368 5.918 1.00 1.00 N +ATOM 86 C2 G A 3 -5.372 -35.330 5.192 1.00 1.00 C +ATOM 87 N2 G A 3 -6.546 -35.727 5.681 1.00 1.00 N +ATOM 88 N3 G A 3 -4.905 -35.859 4.057 1.00 1.00 N +ATOM 89 C4 G A 3 -3.706 -35.340 3.705 1.00 1.00 C +ATOM 90 H5' G A 3 0.082 -37.308 -0.326 1.00 1.00 H +ATOM 91 H5'' G A 3 -0.502 -36.367 -1.712 1.00 1.00 H +ATOM 92 H4' G A 3 -2.257 -37.852 -0.894 1.00 1.00 H +ATOM 93 H3' G A 3 -2.667 -34.892 -0.577 1.00 1.00 H +ATOM 94 H2' G A 3 -4.596 -35.165 0.705 1.00 1.00 H +ATOM 95 HO2' G A 3 -4.702 -37.801 -0.387 1.00 1.00 H +ATOM 96 H1' G A 3 -3.942 -37.469 2.071 1.00 1.00 H +ATOM 97 H8 G A 3 -1.060 -34.947 1.887 1.00 1.00 H +ATOM 98 H1 G A 3 -5.121 -34.018 6.767 1.00 1.00 H +ATOM 99 H21 G A 3 -6.896 -35.328 6.537 1.00 1.00 H +ATOM 100 H22 G A 3 -7.083 -36.430 5.194 1.00 1.00 H +ATOM 101 P A A 4 -3.916 -34.940 -2.969 1.00 1.00 P +ATOM 102 OP1 A A 4 -4.345 -35.520 -4.263 1.00 1.00 O +ATOM 103 OP2 A A 4 -2.760 -34.017 -2.923 1.00 1.00 O +ATOM 104 O5' A A 4 -5.182 -34.195 -2.310 1.00 1.00 O +ATOM 105 C5' A A 4 -6.509 -34.693 -2.511 1.00 1.00 C +ATOM 106 C4' A A 4 -7.537 -33.851 -1.764 1.00 1.00 C +ATOM 107 O4' A A 4 -7.355 -34.002 -0.358 1.00 1.00 O +ATOM 108 C3' A A 4 -7.454 -32.364 -2.059 1.00 1.00 C +ATOM 109 O3' A A 4 -8.323 -32.039 -3.149 1.00 1.00 O +ATOM 110 C2' A A 4 -7.959 -31.719 -0.778 1.00 1.00 C +ATOM 111 O2' A A 4 -9.365 -31.458 -0.845 1.00 1.00 O +ATOM 112 C1' A A 4 -7.636 -32.757 0.297 1.00 1.00 C +ATOM 113 N9 A A 4 -6.461 -32.419 1.118 1.00 1.00 N +ATOM 114 C8 A A 4 -5.133 -32.613 0.839 1.00 1.00 C +ATOM 115 N7 A A 4 -4.330 -32.214 1.785 1.00 1.00 N +ATOM 116 C5 A A 4 -5.187 -31.719 2.763 1.00 1.00 C +ATOM 117 C6 A A 4 -4.958 -31.147 4.025 1.00 1.00 C +ATOM 118 N6 A A 4 -3.738 -30.970 4.533 1.00 1.00 N +ATOM 119 N1 A A 4 -6.034 -30.767 4.734 1.00 1.00 N +ATOM 120 C2 A A 4 -7.245 -30.945 4.221 1.00 1.00 C +ATOM 121 N3 A A 4 -7.589 -31.468 3.053 1.00 1.00 N +ATOM 122 C4 A A 4 -6.489 -31.840 2.365 1.00 1.00 C +ATOM 123 H5' A A 4 -6.562 -35.721 -2.152 1.00 1.00 H +ATOM 124 H5'' A A 4 -6.738 -34.674 -3.575 1.00 1.00 H +ATOM 125 H4' A A 4 -8.535 -34.206 -2.019 1.00 1.00 H +ATOM 126 H3' A A 4 -6.425 -32.066 -2.267 1.00 1.00 H +ATOM 127 H2' A A 4 -7.406 -30.798 -0.582 1.00 1.00 H +ATOM 128 HO2' A A 4 -9.647 -31.187 0.031 1.00 1.00 H +ATOM 129 H1' A A 4 -8.500 -32.880 0.947 1.00 1.00 H +ATOM 130 H8 A A 4 -4.780 -33.060 -0.091 1.00 1.00 H +ATOM 131 H61 A A 4 -3.627 -30.553 5.445 1.00 1.00 H +ATOM 132 H62 A A 4 -2.925 -31.253 4.006 1.00 1.00 H +ATOM 133 H2 A A 4 -8.072 -30.614 4.849 1.00 1.00 H +ATOM 134 P U A 5 -8.001 -30.788 -4.111 1.00 1.00 P +ATOM 135 OP1 U A 5 -9.126 -30.634 -5.060 1.00 1.00 O +ATOM 136 OP2 U A 5 -6.621 -30.940 -4.621 1.00 1.00 O +ATOM 137 O5' U A 5 -8.028 -29.541 -3.092 1.00 1.00 O +ATOM 138 C5' U A 5 -9.238 -29.161 -2.435 1.00 1.00 C +ATOM 139 C4' U A 5 -8.985 -28.090 -1.377 1.00 1.00 C +ATOM 140 O4' U A 5 -8.197 -28.631 -0.321 1.00 1.00 O +ATOM 141 C3' U A 5 -8.238 -26.874 -1.896 1.00 1.00 C +ATOM 142 O3' U A 5 -9.178 -25.882 -2.316 1.00 1.00 O +ATOM 143 C2' U A 5 -7.464 -26.373 -0.683 1.00 1.00 C +ATOM 144 O2' U A 5 -8.163 -25.313 -0.021 1.00 1.00 O +ATOM 145 C1' U A 5 -7.349 -27.607 0.219 1.00 1.00 C +ATOM 146 N1 U A 5 -5.980 -28.166 0.301 1.00 1.00 N +ATOM 147 C2 U A 5 -5.221 -27.856 1.414 1.00 1.00 C +ATOM 148 O2 U A 5 -5.645 -27.135 2.315 1.00 1.00 O +ATOM 149 N3 U A 5 -3.952 -28.405 1.456 1.00 1.00 N +ATOM 150 C4 U A 5 -3.386 -29.226 0.495 1.00 1.00 C +ATOM 151 O4 U A 5 -2.244 -29.660 0.635 1.00 1.00 O +ATOM 152 C5 U A 5 -4.251 -29.498 -0.631 1.00 1.00 C +ATOM 153 C6 U A 5 -5.497 -28.971 -0.694 1.00 1.00 C +ATOM 154 H5' U A 5 -9.676 -30.037 -1.957 1.00 1.00 H +ATOM 155 H5'' U A 5 -9.938 -28.771 -3.175 1.00 1.00 H +ATOM 156 H4' U A 5 -9.939 -27.769 -0.964 1.00 1.00 H +ATOM 157 H3' U A 5 -7.561 -27.148 -2.706 1.00 1.00 H +ATOM 158 H2' U A 5 -6.469 -26.045 -0.989 1.00 1.00 H +ATOM 159 HO2' U A 5 -8.690 -25.707 0.677 1.00 1.00 H +ATOM 160 H1' U A 5 -7.695 -27.350 1.221 1.00 1.00 H +ATOM 161 H3 U A 5 -3.385 -28.187 2.263 1.00 1.00 H +ATOM 162 H5 U A 5 -3.895 -30.135 -1.440 1.00 1.00 H +ATOM 163 H6 U A 5 -6.128 -29.193 -1.554 1.00 1.00 H +ATOM 164 P A A 6 -8.681 -24.550 -3.070 1.00 1.00 P +ATOM 165 OP1 A A 6 -9.756 -24.108 -3.987 1.00 1.00 O +ATOM 166 OP2 A A 6 -7.319 -24.792 -3.593 1.00 1.00 O +ATOM 167 O5' A A 6 -8.578 -23.491 -1.865 1.00 1.00 O +ATOM 168 C5' A A 6 -9.623 -23.404 -0.894 1.00 1.00 C +ATOM 169 C4' A A 6 -9.508 -22.134 -0.056 1.00 1.00 C +ATOM 170 O4' A A 6 -8.148 -21.959 0.360 1.00 1.00 O +ATOM 171 C3' A A 6 -9.931 -20.866 -0.803 1.00 1.00 C +ATOM 172 O3' A A 6 -10.872 -20.125 -0.008 1.00 1.00 O +ATOM 173 C2' A A 6 -8.645 -20.067 -0.963 1.00 1.00 C +ATOM 174 O2' A A 6 -8.893 -18.667 -0.834 1.00 1.00 O +ATOM 175 C1' A A 6 -7.776 -20.596 0.166 1.00 1.00 C +ATOM 176 N9 A A 6 -6.324 -20.552 -0.098 1.00 1.00 N +ATOM 177 C8 A A 6 -5.627 -21.026 -1.179 1.00 1.00 C +ATOM 178 N7 A A 6 -4.339 -20.837 -1.102 1.00 1.00 N +ATOM 179 C5 A A 6 -4.171 -20.189 0.118 1.00 1.00 C +ATOM 180 C6 A A 6 -3.033 -19.711 0.790 1.00 1.00 C +ATOM 181 N6 A A 6 -1.796 -19.822 0.302 1.00 1.00 N +ATOM 182 N1 A A 6 -3.224 -19.118 1.980 1.00 1.00 N +ATOM 183 C2 A A 6 -4.457 -19.013 2.462 1.00 1.00 C +ATOM 184 N3 A A 6 -5.600 -19.420 1.930 1.00 1.00 N +ATOM 185 C4 A A 6 -5.375 -20.011 0.736 1.00 1.00 C +ATOM 186 H5' A A 6 -9.571 -24.272 -0.236 1.00 1.00 H +ATOM 187 H5'' A A 6 -10.584 -23.404 -1.409 1.00 1.00 H +ATOM 188 H4' A A 6 -10.128 -22.242 0.831 1.00 1.00 H +ATOM 189 H3' A A 6 -10.353 -21.112 -1.780 1.00 1.00 H +ATOM 190 H2' A A 6 -8.183 -20.292 -1.928 1.00 1.00 H +ATOM 191 HO2' A A 6 -9.842 -18.536 -0.904 1.00 1.00 H +ATOM 192 H1' A A 6 -7.989 -20.038 1.071 1.00 1.00 H +ATOM 193 H8 A A 6 -6.107 -21.514 -2.028 1.00 1.00 H +ATOM 194 H61 A A 6 -1.016 -19.459 0.830 1.00 1.00 H +ATOM 195 H62 A A 6 -1.638 -20.264 -0.585 1.00 1.00 H +ATOM 196 H2 A A 6 -4.540 -18.519 3.430 1.00 1.00 H +ATOM 197 P U A 7 -10.530 -19.662 1.501 1.00 1.00 P +ATOM 198 OP1 U A 7 -9.757 -20.739 2.160 1.00 1.00 O +ATOM 199 OP2 U A 7 -11.777 -19.163 2.123 1.00 1.00 O +ATOM 200 O5' U A 7 -9.550 -18.404 1.264 1.00 1.00 O +ATOM 201 C5' U A 7 -8.775 -17.842 2.327 1.00 1.00 C +ATOM 202 C4' U A 7 -7.871 -16.720 1.820 1.00 1.00 C +ATOM 203 O4' U A 7 -7.327 -17.073 0.541 1.00 1.00 O +ATOM 204 C3' U A 7 -8.594 -15.372 1.655 1.00 1.00 C +ATOM 205 O3' U A 7 -7.837 -14.310 2.261 1.00 1.00 O +ATOM 206 C2' U A 7 -8.633 -15.153 0.149 1.00 1.00 C +ATOM 207 O2' U A 7 -8.504 -13.766 -0.181 1.00 1.00 O +ATOM 208 C1' U A 7 -7.442 -15.953 -0.341 1.00 1.00 C +ATOM 209 N1 U A 7 -7.561 -16.488 -1.716 1.00 1.00 N +ATOM 210 C2 U A 7 -8.321 -15.788 -2.633 1.00 1.00 C +ATOM 211 O2 U A 7 -8.851 -14.714 -2.358 1.00 1.00 O +ATOM 212 N3 U A 7 -8.452 -16.367 -3.882 1.00 1.00 N +ATOM 213 C4 U A 7 -7.895 -17.568 -4.289 1.00 1.00 C +ATOM 214 O4 U A 7 -8.079 -17.990 -5.429 1.00 1.00 O +ATOM 215 C5 U A 7 -7.116 -18.231 -3.268 1.00 1.00 C +ATOM 216 C6 U A 7 -6.973 -17.683 -2.036 1.00 1.00 C +ATOM 217 H5' U A 7 -8.160 -18.619 2.777 1.00 1.00 H +ATOM 218 H5'' U A 7 -9.449 -17.442 3.085 1.00 1.00 H +ATOM 219 H4' U A 7 -7.045 -16.608 2.514 1.00 1.00 H +ATOM 220 H3' U A 7 -9.604 -15.418 2.062 1.00 1.00 H +ATOM 221 H2' U A 7 -9.551 -15.571 -0.269 1.00 1.00 H +ATOM 222 HO2' U A 7 -8.071 -13.336 0.562 1.00 1.00 H +ATOM 223 H1' U A 7 -6.545 -15.340 -0.269 1.00 1.00 H +ATOM 224 H3 U A 7 -9.006 -15.867 -4.562 1.00 1.00 H +ATOM 225 H5 U A 7 -6.637 -19.184 -3.491 1.00 1.00 H +ATOM 226 H6 U A 7 -6.380 -18.205 -1.285 1.00 1.00 H +ATOM 227 P G A 8 -7.242 -14.454 3.751 1.00 1.00 P +ATOM 228 OP1 G A 8 -8.198 -15.251 4.555 1.00 1.00 O +ATOM 229 OP2 G A 8 -6.815 -13.116 4.217 1.00 1.00 O +ATOM 230 O5' G A 8 -5.927 -15.352 3.491 1.00 1.00 O +ATOM 231 C5' G A 8 -4.810 -15.302 4.384 1.00 1.00 C +ATOM 232 C4' G A 8 -3.562 -14.745 3.701 1.00 1.00 C +ATOM 233 O4' G A 8 -2.984 -15.738 2.849 1.00 1.00 O +ATOM 234 C3' G A 8 -3.829 -13.518 2.843 1.00 1.00 C +ATOM 235 O3' G A 8 -3.544 -12.338 3.597 1.00 1.00 O +ATOM 236 C2' G A 8 -2.841 -13.643 1.693 1.00 1.00 C +ATOM 237 O2' G A 8 -1.643 -12.908 1.955 1.00 1.00 O +ATOM 238 C1' G A 8 -2.567 -15.140 1.610 1.00 1.00 C +ATOM 239 N9 G A 8 -3.302 -15.819 0.528 1.00 1.00 N +ATOM 240 C8 G A 8 -4.463 -16.540 0.624 1.00 1.00 C +ATOM 241 N7 G A 8 -4.881 -17.026 -0.511 1.00 1.00 N +ATOM 242 C5 G A 8 -3.927 -16.599 -1.430 1.00 1.00 C +ATOM 243 C6 G A 8 -3.854 -16.824 -2.833 1.00 1.00 C +ATOM 244 O6 G A 8 -4.632 -17.452 -3.547 1.00 1.00 O +ATOM 245 N1 G A 8 -2.733 -16.221 -3.387 1.00 1.00 N +ATOM 246 C2 G A 8 -1.798 -15.492 -2.685 1.00 1.00 C +ATOM 247 N2 G A 8 -0.788 -14.992 -3.395 1.00 1.00 N +ATOM 248 N3 G A 8 -1.865 -15.276 -1.364 1.00 1.00 N +ATOM 249 C4 G A 8 -2.955 -15.858 -0.805 1.00 1.00 C +ATOM 250 H5' G A 8 -4.599 -16.311 4.739 1.00 1.00 H +ATOM 251 H5'' G A 8 -5.062 -14.671 5.235 1.00 1.00 H +ATOM 252 H4' G A 8 -2.834 -14.483 4.466 1.00 1.00 H +ATOM 253 H3' G A 8 -4.857 -13.516 2.477 1.00 1.00 H +ATOM 254 H2' G A 8 -3.307 -13.301 0.766 1.00 1.00 H +ATOM 255 HO2' G A 8 -1.765 -12.450 2.790 1.00 1.00 H +ATOM 256 H1' G A 8 -1.499 -15.303 1.472 1.00 1.00 H +ATOM 257 H8 G A 8 -4.988 -16.699 1.565 1.00 1.00 H +ATOM 258 H1 G A 8 -2.614 -16.337 -4.384 1.00 1.00 H +ATOM 259 H21 G A 8 -0.744 -15.159 -4.393 1.00 1.00 H +ATOM 260 H22 G A 8 -0.072 -14.450 -2.948 1.00 1.00 H +ATOM 261 P G A 9 -3.994 -10.895 3.046 1.00 1.00 P +ATOM 262 OP1 G A 9 -3.611 -9.875 4.046 1.00 1.00 O +ATOM 263 OP2 G A 9 -5.397 -10.992 2.585 1.00 1.00 O +ATOM 264 O5' G A 9 -3.049 -10.714 1.754 1.00 1.00 O +ATOM 265 C5' G A 9 -3.622 -10.473 0.469 1.00 1.00 C +ATOM 266 C4' G A 9 -2.551 -10.349 -0.606 1.00 1.00 C +ATOM 267 O4' G A 9 -2.210 -11.646 -1.102 1.00 1.00 O +ATOM 268 C3' G A 9 -2.978 -9.511 -1.801 1.00 1.00 C +ATOM 269 O3' G A 9 -2.546 -8.158 -1.615 1.00 1.00 O +ATOM 270 C2' G A 9 -2.231 -10.143 -2.963 1.00 1.00 C +ATOM 271 O2' G A 9 -0.965 -9.510 -3.177 1.00 1.00 O +ATOM 272 C1' G A 9 -2.065 -11.594 -2.528 1.00 1.00 C +ATOM 273 N9 G A 9 -3.066 -12.506 -3.114 1.00 1.00 N +ATOM 274 C8 G A 9 -3.989 -13.292 -2.475 1.00 1.00 C +ATOM 275 N7 G A 9 -4.732 -13.997 -3.282 1.00 1.00 N +ATOM 276 C5 G A 9 -4.269 -13.654 -4.550 1.00 1.00 C +ATOM 277 C6 G A 9 -4.697 -14.103 -5.829 1.00 1.00 C +ATOM 278 O6 G A 9 -5.589 -14.908 -6.096 1.00 1.00 O +ATOM 279 N1 G A 9 -3.967 -13.509 -6.849 1.00 1.00 N +ATOM 280 C2 G A 9 -2.950 -12.595 -6.665 1.00 1.00 C +ATOM 281 N2 G A 9 -2.363 -12.135 -7.771 1.00 1.00 N +ATOM 282 N3 G A 9 -2.546 -12.171 -5.464 1.00 1.00 N +ATOM 283 C4 G A 9 -3.248 -12.741 -4.456 1.00 1.00 C +ATOM 284 H5' G A 9 -4.199 -9.549 0.505 1.00 1.00 H +ATOM 285 H5'' G A 9 -4.288 -11.299 0.215 1.00 1.00 H +ATOM 286 H4' G A 9 -1.660 -9.904 -0.166 1.00 1.00 H +ATOM 287 H3' G A 9 -4.057 -9.570 -1.951 1.00 1.00 H +ATOM 288 H2' G A 9 -2.839 -10.100 -3.863 1.00 1.00 H +ATOM 289 HO2' G A 9 -0.337 -9.918 -2.576 1.00 1.00 H +ATOM 290 H1' G A 9 -1.069 -11.937 -2.801 1.00 1.00 H +ATOM 291 H8 G A 9 -4.091 -13.329 -1.390 1.00 1.00 H +ATOM 292 H1 G A 9 -4.216 -13.779 -7.790 1.00 1.00 H +ATOM 293 H21 G A 9 -2.670 -12.457 -8.678 1.00 1.00 H +ATOM 294 H22 G A 9 -1.613 -11.464 -7.701 1.00 1.00 H +ATOM 295 P A A 10 -3.456 -6.931 -2.122 1.00 1.00 P +ATOM 296 OP1 A A 10 -2.816 -5.669 -1.687 1.00 1.00 O +ATOM 297 OP2 A A 10 -4.860 -7.213 -1.749 1.00 1.00 O +ATOM 298 O5' A A 10 -3.331 -7.032 -3.723 1.00 1.00 O +ATOM 299 C5' A A 10 -2.084 -6.773 -4.372 1.00 1.00 C +ATOM 300 C4' A A 10 -2.189 -6.960 -5.882 1.00 1.00 C +ATOM 301 O4' A A 10 -2.382 -8.334 -6.194 1.00 1.00 O +ATOM 302 C3' A A 10 -3.343 -6.214 -6.528 1.00 1.00 C +ATOM 303 O3' A A 10 -2.929 -4.891 -6.882 1.00 1.00 O +ATOM 304 C2' A A 10 -3.635 -7.031 -7.777 1.00 1.00 C +ATOM 305 O2' A A 10 -2.955 -6.500 -8.919 1.00 1.00 O +ATOM 306 C1' A A 10 -3.119 -8.428 -7.421 1.00 1.00 C +ATOM 307 N9 A A 10 -4.186 -9.422 -7.216 1.00 1.00 N +ATOM 308 C8 A A 10 -4.822 -9.778 -6.055 1.00 1.00 C +ATOM 309 N7 A A 10 -5.724 -10.707 -6.211 1.00 1.00 N +ATOM 310 C5 A A 10 -5.684 -10.985 -7.574 1.00 1.00 C +ATOM 311 C6 A A 10 -6.402 -11.883 -8.381 1.00 1.00 C +ATOM 312 N6 A A 10 -7.342 -12.702 -7.904 1.00 1.00 N +ATOM 313 N1 A A 10 -6.112 -11.901 -9.692 1.00 1.00 N +ATOM 314 C2 A A 10 -5.175 -11.084 -10.160 1.00 1.00 C +ATOM 315 N3 A A 10 -4.435 -10.200 -9.507 1.00 1.00 N +ATOM 316 C4 A A 10 -4.750 -10.206 -8.195 1.00 1.00 C +ATOM 317 H5' A A 10 -1.329 -7.456 -3.980 1.00 1.00 H +ATOM 318 H5'' A A 10 -1.780 -5.747 -4.161 1.00 1.00 H +ATOM 319 H4' A A 10 -1.258 -6.634 -6.341 1.00 1.00 H +ATOM 320 H3' A A 10 -4.210 -6.196 -5.866 1.00 1.00 H +ATOM 321 H2' A A 10 -4.712 -7.068 -7.952 1.00 1.00 H +ATOM 322 HO2' A A 10 -2.071 -6.250 -8.636 1.00 1.00 H +ATOM 323 H1' A A 10 -2.456 -8.778 -8.211 1.00 1.00 H +ATOM 324 H8 A A 10 -4.594 -9.325 -5.089 1.00 1.00 H +ATOM 325 H61 A A 10 -7.829 -13.329 -8.528 1.00 1.00 H +ATOM 326 H62 A A 10 -7.566 -12.694 -6.921 1.00 1.00 H +ATOM 327 H2 A A 10 -4.990 -11.150 -11.232 1.00 1.00 H +ATOM 328 P A A 11 -4.022 -3.728 -7.102 1.00 1.00 P +ATOM 329 OP1 A A 11 -3.306 -2.441 -7.251 1.00 1.00 O +ATOM 330 OP2 A A 11 -5.068 -3.876 -6.066 1.00 1.00 O +ATOM 331 O5' A A 11 -4.666 -4.116 -8.526 1.00 1.00 O +ATOM 332 C5' A A 11 -3.882 -4.044 -9.721 1.00 1.00 C +ATOM 333 C4' A A 11 -4.680 -4.487 -10.944 1.00 1.00 C +ATOM 334 O4' A A 11 -4.951 -5.884 -10.878 1.00 1.00 O +ATOM 335 C3' A A 11 -6.026 -3.799 -11.095 1.00 1.00 C +ATOM 336 O3' A A 11 -5.874 -2.574 -11.827 1.00 1.00 O +ATOM 337 C2' A A 11 -6.821 -4.802 -11.909 1.00 1.00 C +ATOM 338 O2' A A 11 -6.682 -4.569 -13.313 1.00 1.00 O +ATOM 339 C1' A A 11 -6.223 -6.142 -11.493 1.00 1.00 C +ATOM 340 N9 A A 11 -7.055 -6.882 -10.530 1.00 1.00 N +ATOM 341 C8 A A 11 -7.155 -6.724 -9.171 1.00 1.00 C +ATOM 342 N7 A A 11 -7.989 -7.552 -8.604 1.00 1.00 N +ATOM 343 C5 A A 11 -8.476 -8.312 -9.663 1.00 1.00 C +ATOM 344 C6 A A 11 -9.402 -9.367 -9.728 1.00 1.00 C +ATOM 345 N6 A A 11 -10.026 -9.858 -8.656 1.00 1.00 N +ATOM 346 N1 A A 11 -9.654 -9.892 -10.939 1.00 1.00 N +ATOM 347 C2 A A 11 -9.029 -9.399 -12.002 1.00 1.00 C +ATOM 348 N3 A A 11 -8.144 -8.417 -12.069 1.00 1.00 N +ATOM 349 C4 A A 11 -7.912 -7.911 -10.839 1.00 1.00 C +ATOM 350 H5' A A 11 -3.009 -4.690 -9.614 1.00 1.00 H +ATOM 351 H5'' A A 11 -3.550 -3.018 -9.868 1.00 1.00 H +ATOM 352 H4' A A 11 -4.086 -4.296 -11.837 1.00 1.00 H +ATOM 353 H3' A A 11 -6.489 -3.632 -10.121 1.00 1.00 H +ATOM 354 H2' A A 11 -7.863 -4.766 -11.612 1.00 1.00 H +ATOM 355 HO2' A A 11 -7.285 -3.859 -13.543 1.00 1.00 H +ATOM 356 H1' A A 11 -6.075 -6.760 -12.380 1.00 1.00 H +ATOM 357 H8 A A 11 -6.592 -5.973 -8.617 1.00 1.00 H +ATOM 358 H61 A A 11 -10.681 -10.614 -8.757 1.00 1.00 H +ATOM 359 H62 A A 11 -9.843 -9.468 -7.747 1.00 1.00 H +ATOM 360 H2 A A 11 -9.281 -9.870 -12.953 1.00 1.00 H +ATOM 361 P G A 12 -6.866 -1.330 -11.565 1.00 1.00 P +ATOM 362 OP1 G A 12 -6.197 -0.101 -12.045 1.00 1.00 O +ATOM 363 OP2 G A 12 -7.342 -1.409 -10.166 1.00 1.00 O +ATOM 364 O5' G A 12 -8.116 -1.639 -12.540 1.00 1.00 O +ATOM 365 C5' G A 12 -8.064 -1.296 -13.930 1.00 1.00 C +ATOM 366 C4' G A 12 -9.242 -1.889 -14.704 1.00 1.00 C +ATOM 367 O4' G A 12 -9.282 -3.301 -14.509 1.00 1.00 O +ATOM 368 C3' G A 12 -10.609 -1.351 -14.295 1.00 1.00 C +ATOM 369 O3' G A 12 -10.954 -0.231 -15.120 1.00 1.00 O +ATOM 370 C2' G A 12 -11.540 -2.520 -14.585 1.00 1.00 C +ATOM 371 O2' G A 12 -12.040 -2.474 -15.926 1.00 1.00 O +ATOM 372 C1' G A 12 -10.644 -3.726 -14.366 1.00 1.00 C +ATOM 373 N9 G A 12 -10.790 -4.312 -13.029 1.00 1.00 N +ATOM 374 C8 G A 12 -10.186 -3.940 -11.855 1.00 1.00 C +ATOM 375 N7 G A 12 -10.512 -4.683 -10.835 1.00 1.00 N +ATOM 376 C5 G A 12 -11.397 -5.616 -11.368 1.00 1.00 C +ATOM 377 C6 G A 12 -12.086 -6.686 -10.733 1.00 1.00 C +ATOM 378 O6 G A 12 -12.045 -7.027 -9.553 1.00 1.00 O +ATOM 379 N1 G A 12 -12.882 -7.384 -11.632 1.00 1.00 N +ATOM 380 C2 G A 12 -13.002 -7.092 -12.973 1.00 1.00 C +ATOM 381 N2 G A 12 -13.820 -7.875 -13.677 1.00 1.00 N +ATOM 382 N3 G A 12 -12.356 -6.087 -13.573 1.00 1.00 N +ATOM 383 C4 G A 12 -11.574 -5.395 -12.711 1.00 1.00 C +ATOM 384 H5' G A 12 -7.135 -1.675 -14.355 1.00 1.00 H +ATOM 385 H5'' G A 12 -8.083 -0.211 -14.030 1.00 1.00 H +ATOM 386 H4' G A 12 -9.095 -1.695 -15.765 1.00 1.00 H +ATOM 387 H3' G A 12 -10.626 -1.091 -13.235 1.00 1.00 H +ATOM 388 H2' G A 12 -12.361 -2.546 -13.864 1.00 1.00 H +ATOM 389 HO2' G A 12 -11.280 -2.437 -16.513 1.00 1.00 H +ATOM 390 H1' G A 12 -10.867 -4.487 -15.114 1.00 1.00 H +ATOM 391 H8 G A 12 -9.496 -3.100 -11.782 1.00 1.00 H +ATOM 392 H1 G A 12 -13.403 -8.161 -11.253 1.00 1.00 H +ATOM 393 H21 G A 12 -14.307 -8.633 -13.223 1.00 1.00 H +ATOM 394 H22 G A 12 -13.950 -7.711 -14.666 1.00 1.00 H +ATOM 395 P A A 13 -11.894 0.950 -14.556 1.00 1.00 P +ATOM 396 OP1 A A 13 -12.051 1.964 -15.623 1.00 1.00 O +ATOM 397 OP2 A A 13 -11.383 1.353 -13.227 1.00 1.00 O +ATOM 398 O5' A A 13 -13.312 0.215 -14.349 1.00 1.00 O +ATOM 399 C5' A A 13 -14.152 -0.070 -15.469 1.00 1.00 C +ATOM 400 C4' A A 13 -15.390 -0.857 -15.057 1.00 1.00 C +ATOM 401 O4' A A 13 -15.011 -2.146 -14.582 1.00 1.00 O +ATOM 402 C3' A A 13 -16.205 -0.215 -13.946 1.00 1.00 C +ATOM 403 O3' A A 13 -17.155 0.699 -14.513 1.00 1.00 O +ATOM 404 C2' A A 13 -16.916 -1.407 -13.330 1.00 1.00 C +ATOM 405 O2' A A 13 -18.167 -1.663 -13.981 1.00 1.00 O +ATOM 406 C1' A A 13 -15.923 -2.552 -13.551 1.00 1.00 C +ATOM 407 N9 A A 13 -15.130 -2.897 -12.360 1.00 1.00 N +ATOM 408 C8 A A 13 -14.004 -2.296 -11.859 1.00 1.00 C +ATOM 409 N7 A A 13 -13.538 -2.867 -10.782 1.00 1.00 N +ATOM 410 C5 A A 13 -14.419 -3.921 -10.555 1.00 1.00 C +ATOM 411 C6 A A 13 -14.477 -4.912 -9.562 1.00 1.00 C +ATOM 412 N6 A A 13 -13.593 -5.003 -8.567 1.00 1.00 N +ATOM 413 N1 A A 13 -15.483 -5.800 -9.636 1.00 1.00 N +ATOM 414 C2 A A 13 -16.361 -5.704 -10.628 1.00 1.00 C +ATOM 415 N3 A A 13 -16.412 -4.823 -11.615 1.00 1.00 N +ATOM 416 C4 A A 13 -15.391 -3.945 -11.513 1.00 1.00 C +ATOM 417 H5' A A 13 -13.589 -0.654 -16.199 1.00 1.00 H +ATOM 418 H5'' A A 13 -14.464 0.867 -15.928 1.00 1.00 H +ATOM 419 H4' A A 13 -16.029 -0.989 -15.927 1.00 1.00 H +ATOM 420 H3' A A 13 -15.555 0.277 -13.219 1.00 1.00 H +ATOM 421 H2' A A 13 -17.064 -1.243 -12.262 1.00 1.00 H +ATOM 422 HO2' A A 13 -18.021 -2.369 -14.614 1.00 1.00 H +ATOM 423 H1' A A 13 -16.463 -3.443 -13.878 1.00 1.00 H +ATOM 424 H8 A A 13 -13.541 -1.421 -12.317 1.00 1.00 H +ATOM 425 H61 A A 13 -13.688 -5.746 -7.874 1.00 1.00 H +ATOM 426 H62 A A 13 -12.834 -4.342 -8.500 1.00 1.00 H +ATOM 427 H2 A A 13 -17.150 -6.455 -10.627 1.00 1.00 H +ATOM 428 P A A 14 -17.390 2.156 -13.868 1.00 1.00 P +ATOM 429 OP1 A A 14 -18.265 2.927 -14.781 1.00 1.00 O +ATOM 430 OP2 A A 14 -16.075 2.705 -13.472 1.00 1.00 O +ATOM 431 O5' A A 14 -18.224 1.829 -12.529 1.00 1.00 O +ATOM 432 C5' A A 14 -19.638 1.625 -12.592 1.00 1.00 C +ATOM 433 C4' A A 14 -20.169 0.970 -11.319 1.00 1.00 C +ATOM 434 O4' A A 14 -19.481 -0.255 -11.083 1.00 1.00 O +ATOM 435 C3' A A 14 -19.998 1.801 -10.058 1.00 1.00 C +ATOM 436 O3' A A 14 -21.144 2.645 -9.868 1.00 1.00 O +ATOM 437 C2' A A 14 -19.931 0.757 -8.956 1.00 1.00 C +ATOM 438 O2' A A 14 -21.208 0.561 -8.341 1.00 1.00 O +ATOM 439 C1' A A 14 -19.454 -0.507 -9.670 1.00 1.00 C +ATOM 440 N9 A A 14 -18.085 -0.909 -9.306 1.00 1.00 N +ATOM 441 C8 A A 14 -16.889 -0.467 -9.813 1.00 1.00 C +ATOM 442 N7 A A 14 -15.846 -1.034 -9.273 1.00 1.00 N +ATOM 443 C5 A A 14 -16.389 -1.914 -8.342 1.00 1.00 C +ATOM 444 C6 A A 14 -15.808 -2.816 -7.435 1.00 1.00 C +ATOM 445 N6 A A 14 -14.491 -2.984 -7.317 1.00 1.00 N +ATOM 446 N1 A A 14 -16.640 -3.533 -6.660 1.00 1.00 N +ATOM 447 C2 A A 14 -17.950 -3.359 -6.782 1.00 1.00 C +ATOM 448 N3 A A 14 -18.614 -2.549 -7.593 1.00 1.00 N +ATOM 449 C4 A A 14 -17.753 -1.844 -8.357 1.00 1.00 C +ATOM 450 H5' A A 14 -19.867 0.983 -13.444 1.00 1.00 H +ATOM 451 H5'' A A 14 -20.130 2.586 -12.728 1.00 1.00 H +ATOM 452 H4' A A 14 -21.226 0.747 -11.454 1.00 1.00 H +ATOM 453 H3' A A 14 -19.077 2.384 -10.099 1.00 1.00 H +ATOM 454 H2' A A 14 -19.192 1.057 -8.218 1.00 1.00 H +ATOM 455 HO2' A A 14 -21.066 0.535 -7.393 1.00 1.00 H +ATOM 456 H1' A A 14 -20.134 -1.327 -9.442 1.00 1.00 H +ATOM 457 H8 A A 14 -16.817 0.290 -10.594 1.00 1.00 H +ATOM 458 H61 A A 14 -14.128 -3.645 -6.652 1.00 1.00 H +ATOM 459 H62 A A 14 -13.858 -2.451 -7.895 1.00 1.00 H +ATOM 460 H2 A A 14 -18.567 -3.971 -6.123 1.00 1.00 H +ATOM 461 P C A 15 -21.064 3.942 -8.912 1.00 1.00 P +ATOM 462 OP1 C A 15 -22.296 4.738 -9.110 1.00 1.00 O +ATOM 463 OP2 C A 15 -19.740 4.573 -9.107 1.00 1.00 O +ATOM 464 O5' C A 15 -21.103 3.308 -7.428 1.00 1.00 O +ATOM 465 C5' C A 15 -22.346 2.903 -6.841 1.00 1.00 C +ATOM 466 C4' C A 15 -22.148 2.282 -5.457 1.00 1.00 C +ATOM 467 O4' C A 15 -21.359 1.100 -5.562 1.00 1.00 O +ATOM 468 C3' C A 15 -21.432 3.172 -4.457 1.00 1.00 C +ATOM 469 O3' C A 15 -22.376 3.996 -3.765 1.00 1.00 O +ATOM 470 C2' C A 15 -20.806 2.177 -3.494 1.00 1.00 C +ATOM 471 O2' C A 15 -21.673 1.902 -2.387 1.00 1.00 O +ATOM 472 C1' C A 15 -20.590 0.933 -4.356 1.00 1.00 C +ATOM 473 N1 C A 15 -19.184 0.730 -4.754 1.00 1.00 N +ATOM 474 C2 C A 15 -18.442 -0.227 -4.078 1.00 1.00 C +ATOM 475 O2 C A 15 -18.959 -0.877 -3.170 1.00 1.00 O +ATOM 476 N3 C A 15 -17.146 -0.421 -4.448 1.00 1.00 N +ATOM 477 C4 C A 15 -16.600 0.296 -5.441 1.00 1.00 C +ATOM 478 N4 C A 15 -15.327 0.084 -5.778 1.00 1.00 N +ATOM 479 C5 C A 15 -17.362 1.284 -6.141 1.00 1.00 C +ATOM 480 C6 C A 15 -18.643 1.466 -5.768 1.00 1.00 C +ATOM 481 H5' C A 15 -22.825 2.173 -7.492 1.00 1.00 H +ATOM 482 H5'' C A 15 -22.996 3.774 -6.748 1.00 1.00 H +ATOM 483 H4' C A 15 -23.120 2.009 -5.051 1.00 1.00 H +ATOM 484 H3' C A 15 -20.666 3.772 -4.950 1.00 1.00 H +ATOM 485 H2' C A 15 -19.845 2.556 -3.144 1.00 1.00 H +ATOM 486 HO2' C A 15 -21.134 1.514 -1.694 1.00 1.00 H +ATOM 487 H1' C A 15 -20.949 0.057 -3.819 1.00 1.00 H +ATOM 488 H41 C A 15 -14.782 -0.614 -5.282 1.00 1.00 H +ATOM 489 H42 C A 15 -14.907 0.619 -6.524 1.00 1.00 H +ATOM 490 H5 C A 15 -16.921 1.866 -6.950 1.00 1.00 H +ATOM 491 H6 C A 15 -19.253 2.210 -6.279 1.00 1.00 H +ATOM 492 P C A 16 -21.894 5.356 -3.049 1.00 1.00 P +ATOM 493 OP1 C A 16 -23.046 5.919 -2.310 1.00 1.00 O +ATOM 494 OP2 C A 16 -21.185 6.181 -4.052 1.00 1.00 O +ATOM 495 O5' C A 16 -20.816 4.823 -1.975 1.00 1.00 O +ATOM 496 C5' C A 16 -21.232 4.001 -0.882 1.00 1.00 C +ATOM 497 C4' C A 16 -20.070 3.207 -0.285 1.00 1.00 C +ATOM 498 O4' C A 16 -19.401 2.471 -1.304 1.00 1.00 O +ATOM 499 C3' C A 16 -18.999 4.048 0.395 1.00 1.00 C +ATOM 500 O3' C A 16 -19.325 4.208 1.783 1.00 1.00 O +ATOM 501 C2' C A 16 -17.747 3.193 0.273 1.00 1.00 C +ATOM 502 O2' C A 16 -17.486 2.472 1.481 1.00 1.00 O +ATOM 503 C1' C A 16 -18.048 2.250 -0.890 1.00 1.00 C +ATOM 504 N1 C A 16 -17.148 2.415 -2.055 1.00 1.00 N +ATOM 505 C2 C A 16 -16.092 1.523 -2.161 1.00 1.00 C +ATOM 506 O2 C A 16 -15.931 0.655 -1.305 1.00 1.00 O +ATOM 507 N3 C A 16 -15.252 1.639 -3.226 1.00 1.00 N +ATOM 508 C4 C A 16 -15.440 2.591 -4.149 1.00 1.00 C +ATOM 509 N4 C A 16 -14.600 2.675 -5.180 1.00 1.00 N +ATOM 510 C5 C A 16 -16.526 3.516 -4.044 1.00 1.00 C +ATOM 511 C6 C A 16 -17.351 3.393 -2.985 1.00 1.00 C +ATOM 512 H5' C A 16 -21.994 3.305 -1.234 1.00 1.00 H +ATOM 513 H5'' C A 16 -21.661 4.634 -0.106 1.00 1.00 H +ATOM 514 H4' C A 16 -20.469 2.498 0.437 1.00 1.00 H +ATOM 515 H3' C A 16 -18.874 5.009 -0.104 1.00 1.00 H +ATOM 516 H2' C A 16 -16.898 3.831 0.014 1.00 1.00 H +ATOM 517 HO2' C A 16 -18.335 2.220 1.855 1.00 1.00 H +ATOM 518 H1' C A 16 -17.971 1.223 -0.526 1.00 1.00 H +ATOM 519 H41 C A 16 -13.830 2.024 -5.259 1.00 1.00 H +ATOM 520 H42 C A 16 -14.730 3.389 -5.882 1.00 1.00 H +ATOM 521 H5 C A 16 -16.680 4.292 -4.794 1.00 1.00 H +ATOM 522 H6 C A 16 -18.188 4.083 -2.871 1.00 1.00 H +ATOM 523 P G A 17 -18.474 5.206 2.719 1.00 1.00 P +ATOM 524 OP1 G A 17 -19.349 5.657 3.824 1.00 1.00 O +ATOM 525 OP2 G A 17 -17.815 6.203 1.848 1.00 1.00 O +ATOM 526 O5' G A 17 -17.330 4.245 3.341 1.00 1.00 O +ATOM 527 C5' G A 17 -17.665 3.224 4.291 1.00 1.00 C +ATOM 528 C4' G A 17 -16.421 2.508 4.829 1.00 1.00 C +ATOM 529 O4' G A 17 -15.821 1.719 3.801 1.00 1.00 O +ATOM 530 C3' G A 17 -15.337 3.441 5.356 1.00 1.00 C +ATOM 531 O3' G A 17 -15.506 3.640 6.762 1.00 1.00 O +ATOM 532 C2' G A 17 -14.046 2.682 5.098 1.00 1.00 C +ATOM 533 O2' G A 17 -13.654 1.912 6.238 1.00 1.00 O +ATOM 534 C1' G A 17 -14.389 1.786 3.915 1.00 1.00 C +ATOM 535 N9 G A 17 -13.876 2.287 2.636 1.00 1.00 N +ATOM 536 C8 G A 17 -14.560 2.951 1.651 1.00 1.00 C +ATOM 537 N7 G A 17 -13.824 3.285 0.628 1.00 1.00 N +ATOM 538 C5 G A 17 -12.559 2.807 0.955 1.00 1.00 C +ATOM 539 C6 G A 17 -11.342 2.878 0.221 1.00 1.00 C +ATOM 540 O6 G A 17 -11.143 3.386 -0.880 1.00 1.00 O +ATOM 541 N1 G A 17 -10.299 2.274 0.909 1.00 1.00 N +ATOM 542 C2 G A 17 -10.406 1.678 2.146 1.00 1.00 C +ATOM 543 N2 G A 17 -9.287 1.154 2.646 1.00 1.00 N +ATOM 544 N3 G A 17 -11.549 1.609 2.838 1.00 1.00 N +ATOM 545 C4 G A 17 -12.580 2.194 2.182 1.00 1.00 C +ATOM 546 H5' G A 17 -18.312 2.492 3.809 1.00 1.00 H +ATOM 547 H5'' G A 17 -18.202 3.676 5.125 1.00 1.00 H +ATOM 548 H4' G A 17 -16.725 1.841 5.635 1.00 1.00 H +ATOM 549 H3' G A 17 -15.345 4.389 4.816 1.00 1.00 H +ATOM 550 H2' G A 17 -13.255 3.381 4.815 1.00 1.00 H +ATOM 551 HO2' G A 17 -14.403 1.365 6.485 1.00 1.00 H +ATOM 552 H1' G A 17 -13.992 0.786 4.092 1.00 1.00 H +ATOM 553 H8 G A 17 -15.625 3.181 1.717 1.00 1.00 H +ATOM 554 H1 G A 17 -9.400 2.285 0.449 1.00 1.00 H +ATOM 555 H21 G A 17 -8.425 1.207 2.121 1.00 1.00 H +ATOM 556 H22 G A 17 -9.301 0.702 3.550 1.00 1.00 H +ATOM 557 P G A 18 -14.825 4.902 7.495 1.00 1.00 P +ATOM 558 OP1 G A 18 -15.255 4.903 8.911 1.00 1.00 O +ATOM 559 OP2 G A 18 -15.050 6.100 6.655 1.00 1.00 O +ATOM 560 O5' G A 18 -13.256 4.536 7.442 1.00 1.00 O +ATOM 561 C5' G A 18 -12.754 3.378 8.117 1.00 1.00 C +ATOM 562 C4' G A 18 -11.253 3.194 7.887 1.00 1.00 C +ATOM 563 O4' G A 18 -10.995 2.961 6.506 1.00 1.00 O +ATOM 564 C3' G A 18 -10.404 4.389 8.287 1.00 1.00 C +ATOM 565 O3' G A 18 -10.003 4.250 9.657 1.00 1.00 O +ATOM 566 C2' G A 18 -9.194 4.294 7.370 1.00 1.00 C +ATOM 567 O2' G A 18 -8.108 3.614 8.009 1.00 1.00 O +ATOM 568 C1' G A 18 -9.713 3.507 6.164 1.00 1.00 C +ATOM 569 N9 G A 18 -9.895 4.327 4.953 1.00 1.00 N +ATOM 570 C8 G A 18 -10.977 5.088 4.594 1.00 1.00 C +ATOM 571 N7 G A 18 -10.834 5.707 3.455 1.00 1.00 N +ATOM 572 C5 G A 18 -9.565 5.331 3.025 1.00 1.00 C +ATOM 573 C6 G A 18 -8.859 5.693 1.845 1.00 1.00 C +ATOM 574 O6 G A 18 -9.225 6.431 0.933 1.00 1.00 O +ATOM 575 N1 G A 18 -7.607 5.095 1.796 1.00 1.00 N +ATOM 576 C2 G A 18 -7.095 4.253 2.761 1.00 1.00 C +ATOM 577 N2 G A 18 -5.871 3.775 2.537 1.00 1.00 N +ATOM 578 N3 G A 18 -7.756 3.911 3.871 1.00 1.00 N +ATOM 579 C4 G A 18 -8.981 4.486 3.936 1.00 1.00 C +ATOM 580 H5' G A 18 -13.278 2.497 7.747 1.00 1.00 H +ATOM 581 H5'' G A 18 -12.940 3.479 9.185 1.00 1.00 H +ATOM 582 H4' G A 18 -10.918 2.324 8.448 1.00 1.00 H +ATOM 583 H3' G A 18 -10.945 5.323 8.124 1.00 1.00 H +ATOM 584 H2' G A 18 -8.890 5.294 7.055 1.00 1.00 H +ATOM 585 HO2' G A 18 -7.757 2.982 7.377 1.00 1.00 H +ATOM 586 H1' G A 18 -9.022 2.693 5.942 1.00 1.00 H +ATOM 587 H8 G A 18 -11.877 5.166 5.204 1.00 1.00 H +ATOM 588 H1 G A 18 -7.044 5.306 0.984 1.00 1.00 H +ATOM 589 H21 G A 18 -5.374 4.035 1.697 1.00 1.00 H +ATOM 590 H22 G A 18 -5.441 3.153 3.207 1.00 1.00 H +ATOM 591 P G A 19 -9.531 5.529 10.517 1.00 1.00 P +ATOM 592 OP1 G A 19 -9.431 5.119 11.936 1.00 1.00 O +ATOM 593 OP2 G A 19 -10.382 6.680 10.141 1.00 1.00 O +ATOM 594 O5' G A 19 -8.041 5.803 9.968 1.00 1.00 O +ATOM 595 C5' G A 19 -6.995 4.853 10.196 1.00 1.00 C +ATOM 596 C4' G A 19 -5.757 5.172 9.362 1.00 1.00 C +ATOM 597 O4' G A 19 -6.101 5.204 7.980 1.00 1.00 O +ATOM 598 C3' G A 19 -5.117 6.510 9.687 1.00 1.00 C +ATOM 599 O3' G A 19 -4.107 6.323 10.687 1.00 1.00 O +ATOM 600 C2' G A 19 -4.484 6.935 8.369 1.00 1.00 C +ATOM 601 O2' G A 19 -3.106 6.550 8.303 1.00 1.00 O +ATOM 602 C1' G A 19 -5.319 6.204 7.314 1.00 1.00 C +ATOM 603 N9 G A 19 -6.254 7.076 6.582 1.00 1.00 N +ATOM 604 C8 G A 19 -7.507 7.493 6.949 1.00 1.00 C +ATOM 605 N7 G A 19 -8.087 8.264 6.073 1.00 1.00 N +ATOM 606 C5 G A 19 -7.151 8.369 5.048 1.00 1.00 C +ATOM 607 C6 G A 19 -7.222 9.084 3.819 1.00 1.00 C +ATOM 608 O6 G A 19 -8.143 9.776 3.391 1.00 1.00 O +ATOM 609 N1 G A 19 -6.063 8.926 3.070 1.00 1.00 N +ATOM 610 C2 G A 19 -4.971 8.175 3.452 1.00 1.00 C +ATOM 611 N2 G A 19 -3.950 8.144 2.597 1.00 1.00 N +ATOM 612 N3 G A 19 -4.902 7.502 4.606 1.00 1.00 N +ATOM 613 C4 G A 19 -6.025 7.645 5.351 1.00 1.00 C +ATOM 614 H5' G A 19 -7.353 3.857 9.935 1.00 1.00 H +ATOM 615 H5'' G A 19 -6.725 4.869 11.251 1.00 1.00 H +ATOM 616 H4' G A 19 -5.020 4.385 9.513 1.00 1.00 H +ATOM 617 H3' G A 19 -5.868 7.232 10.010 1.00 1.00 H +ATOM 618 H2' G A 19 -4.589 8.016 8.240 1.00 1.00 H +ATOM 619 HO2' G A 19 -2.638 7.245 7.834 1.00 1.00 H +ATOM 620 H1' G A 19 -4.654 5.721 6.597 1.00 1.00 H +ATOM 621 H8 G A 19 -7.978 7.205 7.889 1.00 1.00 H +ATOM 622 H1 G A 19 -6.039 9.406 2.183 1.00 1.00 H +ATOM 623 H21 G A 19 -4.003 8.652 1.728 1.00 1.00 H +ATOM 624 H22 G A 19 -3.122 7.610 2.822 1.00 1.00 H +ATOM 625 P G A 20 -3.855 7.438 11.821 1.00 1.00 P +ATOM 626 OP1 G A 20 -3.064 6.822 12.910 1.00 1.00 O +ATOM 627 OP2 G A 20 -5.149 8.088 12.127 1.00 1.00 O +ATOM 628 O5' G A 20 -2.922 8.507 11.064 1.00 1.00 O +ATOM 629 C5' G A 20 -3.059 9.903 11.333 1.00 1.00 C +ATOM 630 C4' G A 20 -2.607 10.746 10.147 1.00 1.00 C +ATOM 631 O4' G A 20 -3.119 10.185 8.936 1.00 1.00 O +ATOM 632 C3' G A 20 -3.072 12.194 10.213 1.00 1.00 C +ATOM 633 O3' G A 20 -2.026 13.005 10.756 1.00 1.00 O +ATOM 634 C2' G A 20 -3.309 12.562 8.757 1.00 1.00 C +ATOM 635 O2' G A 20 -2.136 13.138 8.172 1.00 1.00 O +ATOM 636 C1' G A 20 -3.653 11.224 8.107 1.00 1.00 C +ATOM 637 N9 G A 20 -5.101 10.975 7.972 1.00 1.00 N +ATOM 638 C8 G A 20 -5.963 10.436 8.891 1.00 1.00 C +ATOM 639 N7 G A 20 -7.192 10.342 8.472 1.00 1.00 N +ATOM 640 C5 G A 20 -7.147 10.855 7.179 1.00 1.00 C +ATOM 641 C6 G A 20 -8.190 11.009 6.226 1.00 1.00 C +ATOM 642 O6 G A 20 -9.378 10.719 6.342 1.00 1.00 O +ATOM 643 N1 G A 20 -7.722 11.566 5.044 1.00 1.00 N +ATOM 644 C2 G A 20 -6.416 11.931 4.804 1.00 1.00 C +ATOM 645 N2 G A 20 -6.162 12.449 3.602 1.00 1.00 N +ATOM 646 N3 G A 20 -5.430 11.789 5.701 1.00 1.00 N +ATOM 647 C4 G A 20 -5.869 11.246 6.862 1.00 1.00 C +ATOM 648 H5' G A 20 -2.452 10.159 12.202 1.00 1.00 H +ATOM 649 H5'' G A 20 -4.103 10.124 11.552 1.00 1.00 H +ATOM 650 H4' G A 20 -1.520 10.730 10.099 1.00 1.00 H +ATOM 651 H3' G A 20 -3.991 12.283 10.794 1.00 1.00 H +ATOM 652 H2' G A 20 -4.158 13.246 8.678 1.00 1.00 H +ATOM 653 HO2' G A 20 -1.723 12.459 7.632 1.00 1.00 H +ATOM 654 H1' G A 20 -3.190 11.173 7.122 1.00 1.00 H +ATOM 655 H8 G A 20 -5.648 10.112 9.883 1.00 1.00 H +ATOM 656 H1 G A 20 -8.409 11.706 4.317 1.00 1.00 H +ATOM 657 H21 G A 20 -6.908 12.554 2.930 1.00 1.00 H +ATOM 658 H22 G A 20 -5.224 12.735 3.366 1.00 1.00 H +ATOM 659 P A A 21 -2.320 14.012 11.977 1.00 1.00 P +ATOM 660 OP1 A A 21 -1.033 14.597 12.416 1.00 1.00 O +ATOM 661 OP2 A A 21 -3.184 13.313 12.955 1.00 1.00 O +ATOM 662 O5' A A 21 -3.189 15.173 11.278 1.00 1.00 O +ATOM 663 C5' A A 21 -4.184 15.882 12.022 1.00 1.00 C +ATOM 664 C4' A A 21 -4.650 17.133 11.281 1.00 1.00 C +ATOM 665 O4' A A 21 -3.584 18.089 11.236 1.00 1.00 O +ATOM 666 C3' A A 21 -5.096 16.864 9.847 1.00 1.00 C +ATOM 667 O3' A A 21 -6.527 16.883 9.784 1.00 1.00 O +ATOM 668 C2' A A 21 -4.530 18.032 9.051 1.00 1.00 C +ATOM 669 O2' A A 21 -5.492 19.083 8.913 1.00 1.00 O +ATOM 670 C1' A A 21 -3.335 18.480 9.882 1.00 1.00 C +ATOM 671 N9 A A 21 -2.053 17.873 9.473 1.00 1.00 N +ATOM 672 C8 A A 21 -1.358 16.861 10.082 1.00 1.00 C +ATOM 673 N7 A A 21 -0.246 16.545 9.476 1.00 1.00 N +ATOM 674 C5 A A 21 -0.204 17.412 8.388 1.00 1.00 C +ATOM 675 C6 A A 21 0.725 17.588 7.350 1.00 1.00 C +ATOM 676 N6 A A 21 1.839 16.863 7.234 1.00 1.00 N +ATOM 677 N1 A A 21 0.459 18.538 6.438 1.00 1.00 N +ATOM 678 C2 A A 21 -0.652 19.256 6.557 1.00 1.00 C +ATOM 679 N3 A A 21 -1.597 19.185 7.481 1.00 1.00 N +ATOM 680 C4 A A 21 -1.301 18.225 8.380 1.00 1.00 C +ATOM 681 H5' A A 21 -3.769 16.173 12.986 1.00 1.00 H +ATOM 682 H5'' A A 21 -5.040 15.227 12.185 1.00 1.00 H +ATOM 683 H4' A A 21 -5.482 17.572 11.828 1.00 1.00 H +ATOM 684 H3' A A 21 -4.695 15.916 9.486 1.00 1.00 H +ATOM 685 H2' A A 21 -4.192 17.686 8.072 1.00 1.00 H +ATOM 686 HO2' A A 21 -6.179 18.931 9.566 1.00 1.00 H +ATOM 687 H1' A A 21 -3.249 19.564 9.832 1.00 1.00 H +ATOM 688 H8 A A 21 -1.703 16.364 10.989 1.00 1.00 H +ATOM 689 H61 A A 21 2.473 17.031 6.466 1.00 1.00 H +ATOM 690 H62 A A 21 2.048 16.147 7.914 1.00 1.00 H +ATOM 691 H2 A A 21 -0.807 20.009 5.785 1.00 1.00 H +ATOM 692 P A A 22 -7.313 16.013 8.680 1.00 1.00 P +ATOM 693 OP1 A A 22 -8.587 15.550 9.276 1.00 1.00 O +ATOM 694 OP2 A A 22 -6.369 15.029 8.106 1.00 1.00 O +ATOM 695 O5' A A 22 -7.656 17.104 7.547 1.00 1.00 O +ATOM 696 C5' A A 22 -7.373 16.833 6.171 1.00 1.00 C +ATOM 697 C4' A A 22 -6.465 17.901 5.572 1.00 1.00 C +ATOM 698 O4' A A 22 -5.271 17.996 6.350 1.00 1.00 O +ATOM 699 C3' A A 22 -6.055 17.627 4.129 1.00 1.00 C +ATOM 700 O3' A A 22 -6.879 18.391 3.242 1.00 1.00 O +ATOM 701 C2' A A 22 -4.621 18.124 4.058 1.00 1.00 C +ATOM 702 O2' A A 22 -4.560 19.493 3.644 1.00 1.00 O +ATOM 703 C1' A A 22 -4.130 17.957 5.488 1.00 1.00 C +ATOM 704 N9 A A 22 -3.432 16.685 5.735 1.00 1.00 N +ATOM 705 C8 A A 22 -3.815 15.630 6.525 1.00 1.00 C +ATOM 706 N7 A A 22 -2.949 14.654 6.558 1.00 1.00 N +ATOM 707 C5 A A 22 -1.920 15.093 5.732 1.00 1.00 C +ATOM 708 C6 A A 22 -0.699 14.516 5.346 1.00 1.00 C +ATOM 709 N6 A A 22 -0.296 13.315 5.765 1.00 1.00 N +ATOM 710 N1 A A 22 0.083 15.224 4.515 1.00 1.00 N +ATOM 711 C2 A A 22 -0.324 16.417 4.102 1.00 1.00 C +ATOM 712 N3 A A 22 -1.442 17.066 4.392 1.00 1.00 N +ATOM 713 C4 A A 22 -2.207 16.330 5.226 1.00 1.00 C +ATOM 714 H5' A A 22 -8.309 16.807 5.613 1.00 1.00 H +ATOM 715 H5'' A A 22 -6.882 15.864 6.091 1.00 1.00 H +ATOM 716 H4' A A 22 -6.978 18.860 5.614 1.00 1.00 H +ATOM 717 H3' A A 22 -6.109 16.560 3.903 1.00 1.00 H +ATOM 718 H2' A A 22 -4.038 17.490 3.388 1.00 1.00 H +ATOM 719 HO2' A A 22 -5.404 19.705 3.236 1.00 1.00 H +ATOM 720 H1' A A 22 -3.462 18.781 5.741 1.00 1.00 H +ATOM 721 H8 A A 22 -4.757 15.609 7.074 1.00 1.00 H +ATOM 722 H61 A A 22 0.591 12.944 5.458 1.00 1.00 H +ATOM 723 H62 A A 22 -0.879 12.778 6.390 1.00 1.00 H +ATOM 724 H2 A A 22 0.358 16.938 3.429 1.00 1.00 H +ATOM 725 P A A 23 -7.612 17.687 1.993 1.00 1.00 P +ATOM 726 OP1 A A 23 -8.404 18.715 1.282 1.00 1.00 O +ATOM 727 OP2 A A 23 -8.269 16.453 2.478 1.00 1.00 O +ATOM 728 O5' A A 23 -6.376 17.264 1.052 1.00 1.00 O +ATOM 729 C5' A A 23 -6.074 18.011 -0.130 1.00 1.00 C +ATOM 730 C4' A A 23 -4.649 17.754 -0.604 1.00 1.00 C +ATOM 731 O4' A A 23 -3.788 17.637 0.530 1.00 1.00 O +ATOM 732 C3' A A 23 -4.487 16.483 -1.429 1.00 1.00 C +ATOM 733 O3' A A 23 -4.529 16.805 -2.823 1.00 1.00 O +ATOM 734 C2' A A 23 -3.100 15.987 -1.057 1.00 1.00 C +ATOM 735 O2' A A 23 -2.107 16.498 -1.954 1.00 1.00 O +ATOM 736 C1' A A 23 -2.902 16.525 0.355 1.00 1.00 C +ATOM 737 N9 A A 23 -3.201 15.543 1.414 1.00 1.00 N +ATOM 738 C8 A A 23 -4.383 15.304 2.066 1.00 1.00 C +ATOM 739 N7 A A 23 -4.317 14.338 2.941 1.00 1.00 N +ATOM 740 C5 A A 23 -2.997 13.907 2.862 1.00 1.00 C +ATOM 741 C6 A A 23 -2.283 12.901 3.537 1.00 1.00 C +ATOM 742 N6 A A 23 -2.827 12.111 4.462 1.00 1.00 N +ATOM 743 N1 A A 23 -0.988 12.744 3.214 1.00 1.00 N +ATOM 744 C2 A A 23 -0.451 13.530 2.291 1.00 1.00 C +ATOM 745 N3 A A 23 -1.013 14.502 1.590 1.00 1.00 N +ATOM 746 C4 A A 23 -2.310 14.637 1.935 1.00 1.00 C +ATOM 747 H5' A A 23 -6.193 19.074 0.080 1.00 1.00 H +ATOM 748 H5'' A A 23 -6.768 17.724 -0.920 1.00 1.00 H +ATOM 749 H4' A A 23 -4.317 18.603 -1.200 1.00 1.00 H +ATOM 750 H3' A A 23 -5.250 15.746 -1.165 1.00 1.00 H +ATOM 751 H2' A A 23 -3.085 14.894 -1.047 1.00 1.00 H +ATOM 752 HO2' A A 23 -2.545 17.124 -2.538 1.00 1.00 H +ATOM 753 H1' A A 23 -1.873 16.865 0.466 1.00 1.00 H +ATOM 754 H8 A A 23 -5.294 15.871 1.871 1.00 1.00 H +ATOM 755 H61 A A 23 -2.267 11.403 4.914 1.00 1.00 H +ATOM 756 H62 A A 23 -3.804 12.219 4.712 1.00 1.00 H +ATOM 757 H2 A A 23 0.603 13.349 2.078 1.00 1.00 H +ATOM 758 P C A 24 -5.293 15.848 -3.870 1.00 1.00 P +ATOM 759 OP1 C A 24 -5.022 16.347 -5.237 1.00 1.00 O +ATOM 760 OP2 C A 24 -6.690 15.683 -3.410 1.00 1.00 O +ATOM 761 O5' C A 24 -4.533 14.439 -3.689 1.00 1.00 O +ATOM 762 C5' C A 24 -3.147 14.312 -4.018 1.00 1.00 C +ATOM 763 C4' C A 24 -2.528 13.081 -3.361 1.00 1.00 C +ATOM 764 O4' C A 24 -2.774 13.113 -1.956 1.00 1.00 O +ATOM 765 C3' C A 24 -3.077 11.757 -3.869 1.00 1.00 C +ATOM 766 O3' C A 24 -2.268 11.275 -4.947 1.00 1.00 O +ATOM 767 C2' C A 24 -2.938 10.833 -2.673 1.00 1.00 C +ATOM 768 O2' C A 24 -1.691 10.129 -2.699 1.00 1.00 O +ATOM 769 C1' C A 24 -3.018 11.779 -1.483 1.00 1.00 C +ATOM 770 N1 C A 24 -4.336 11.775 -0.813 1.00 1.00 N +ATOM 771 C2 C A 24 -4.500 10.923 0.267 1.00 1.00 C +ATOM 772 O2 C A 24 -3.572 10.206 0.633 1.00 1.00 O +ATOM 773 N3 C A 24 -5.708 10.907 0.898 1.00 1.00 N +ATOM 774 C4 C A 24 -6.710 11.695 0.484 1.00 1.00 C +ATOM 775 N4 C A 24 -7.879 11.656 1.124 1.00 1.00 N +ATOM 776 C5 C A 24 -6.542 12.575 -0.631 1.00 1.00 C +ATOM 777 C6 C A 24 -5.345 12.583 -1.247 1.00 1.00 C +ATOM 778 H5' C A 24 -2.617 15.202 -3.676 1.00 1.00 H +ATOM 779 H5'' C A 24 -3.044 14.229 -5.099 1.00 1.00 H +ATOM 780 H4' C A 24 -1.452 13.102 -3.521 1.00 1.00 H +ATOM 781 H3' C A 24 -4.123 11.856 -4.167 1.00 1.00 H +ATOM 782 H2' C A 24 -3.774 10.134 -2.644 1.00 1.00 H +ATOM 783 HO2' C A 24 -1.575 9.723 -1.838 1.00 1.00 H +ATOM 784 H1' C A 24 -2.248 11.509 -0.761 1.00 1.00 H +ATOM 785 H41 C A 24 -8.004 11.037 1.911 1.00 1.00 H +ATOM 786 H42 C A 24 -8.641 12.245 0.821 1.00 1.00 H +ATOM 787 H5 C A 24 -7.356 13.217 -0.970 1.00 1.00 H +ATOM 788 H6 C A 24 -5.182 13.243 -2.100 1.00 1.00 H +ATOM 789 P U A 25 -2.841 10.170 -5.969 1.00 1.00 P +ATOM 790 OP1 U A 25 -1.825 9.942 -7.020 1.00 1.00 O +ATOM 791 OP2 U A 25 -4.219 10.560 -6.346 1.00 1.00 O +ATOM 792 O5' U A 25 -2.926 8.846 -5.050 1.00 1.00 O +ATOM 793 C5' U A 25 -1.741 8.272 -4.490 1.00 1.00 C +ATOM 794 C4' U A 25 -2.065 7.206 -3.443 1.00 1.00 C +ATOM 795 O4' U A 25 -2.898 7.761 -2.428 1.00 1.00 O +ATOM 796 C3' U A 25 -2.802 5.993 -3.985 1.00 1.00 C +ATOM 797 O3' U A 25 -1.863 4.997 -4.406 1.00 1.00 O +ATOM 798 C2' U A 25 -3.589 5.491 -2.785 1.00 1.00 C +ATOM 799 O2' U A 25 -2.868 4.485 -2.070 1.00 1.00 O +ATOM 800 C1' U A 25 -3.787 6.745 -1.934 1.00 1.00 C +ATOM 801 N1 U A 25 -5.158 7.292 -1.989 1.00 1.00 N +ATOM 802 C2 U A 25 -6.051 6.896 -1.011 1.00 1.00 C +ATOM 803 O2 U A 25 -5.738 6.113 -0.117 1.00 1.00 O +ATOM 804 N3 U A 25 -7.323 7.435 -1.096 1.00 1.00 N +ATOM 805 C4 U A 25 -7.772 8.320 -2.060 1.00 1.00 C +ATOM 806 O4 U A 25 -8.930 8.736 -2.039 1.00 1.00 O +ATOM 807 C5 U A 25 -6.774 8.678 -3.042 1.00 1.00 C +ATOM 808 C6 U A 25 -5.520 8.164 -2.980 1.00 1.00 C +ATOM 809 H5' U A 25 -1.151 9.060 -4.023 1.00 1.00 H +ATOM 810 H5'' U A 25 -1.156 7.817 -5.290 1.00 1.00 H +ATOM 811 H4' U A 25 -1.138 6.876 -2.980 1.00 1.00 H +ATOM 812 H3' U A 25 -3.474 6.276 -4.799 1.00 1.00 H +ATOM 813 H2' U A 25 -4.555 5.111 -3.113 1.00 1.00 H +ATOM 814 HO2' U A 25 -3.516 3.887 -1.691 1.00 1.00 H +ATOM 815 H1' U A 25 -3.530 6.519 -0.899 1.00 1.00 H +ATOM 816 H3 U A 25 -7.986 7.154 -0.388 1.00 1.00 H +ATOM 817 H5 U A 25 -7.031 9.371 -3.843 1.00 1.00 H +ATOM 818 H6 U A 25 -4.787 8.451 -3.734 1.00 1.00 H +ATOM 819 P U A 26 -2.318 3.810 -5.397 1.00 1.00 P +ATOM 820 OP1 U A 26 -1.098 3.183 -5.956 1.00 1.00 O +ATOM 821 OP2 U A 26 -3.357 4.339 -6.307 1.00 1.00 O +ATOM 822 O5' U A 26 -3.014 2.749 -4.402 1.00 1.00 O +ATOM 823 C5' U A 26 -2.245 2.077 -3.398 1.00 1.00 C +ATOM 824 C4' U A 26 -3.134 1.451 -2.325 1.00 1.00 C +ATOM 825 O4' U A 26 -3.960 2.450 -1.728 1.00 1.00 O +ATOM 826 C3' U A 26 -4.075 0.373 -2.833 1.00 1.00 C +ATOM 827 O3' U A 26 -3.417 -0.905 -2.806 1.00 1.00 O +ATOM 828 C2' U A 26 -5.215 0.413 -1.822 1.00 1.00 C +ATOM 829 O2' U A 26 -4.998 -0.492 -0.737 1.00 1.00 O +ATOM 830 C1' U A 26 -5.212 1.857 -1.334 1.00 1.00 C +ATOM 831 N1 U A 26 -6.299 2.670 -1.918 1.00 1.00 N +ATOM 832 C2 U A 26 -7.442 2.873 -1.168 1.00 1.00 C +ATOM 833 O2 U A 26 -7.579 2.398 -0.044 1.00 1.00 O +ATOM 834 N3 U A 26 -8.428 3.642 -1.760 1.00 1.00 N +ATOM 835 C4 U A 26 -8.371 4.217 -3.018 1.00 1.00 C +ATOM 836 O4 U A 26 -9.310 4.885 -3.445 1.00 1.00 O +ATOM 837 C5 U A 26 -7.141 3.953 -3.731 1.00 1.00 C +ATOM 838 C6 U A 26 -6.160 3.203 -3.172 1.00 1.00 C +ATOM 839 H5' U A 26 -1.572 2.795 -2.926 1.00 1.00 H +ATOM 840 H5'' U A 26 -1.655 1.295 -3.872 1.00 1.00 H +ATOM 841 H4' U A 26 -2.498 1.024 -1.550 1.00 1.00 H +ATOM 842 H3' U A 26 -4.435 0.615 -3.834 1.00 1.00 H +ATOM 843 H2' U A 26 -6.160 0.203 -2.323 1.00 1.00 H +ATOM 844 HO2' U A 26 -4.163 -0.254 -0.328 1.00 1.00 H +ATOM 845 H1' U A 26 -5.289 1.871 -0.247 1.00 1.00 H +ATOM 846 H3 U A 26 -9.270 3.799 -1.224 1.00 1.00 H +ATOM 847 H5 U A 26 -7.001 4.360 -4.732 1.00 1.00 H +ATOM 848 H6 U A 26 -5.243 3.022 -3.731 1.00 1.00 H +ATOM 849 P G A 27 -3.966 -2.147 -3.683 1.00 1.00 P +ATOM 850 OP1 G A 27 -3.007 -3.267 -3.556 1.00 1.00 O +ATOM 851 OP2 G A 27 -4.345 -1.642 -5.021 1.00 1.00 O +ATOM 852 O5' G A 27 -5.309 -2.543 -2.895 1.00 1.00 O +ATOM 853 C5' G A 27 -5.237 -2.864 -1.507 1.00 1.00 C +ATOM 854 C4' G A 27 -6.583 -2.678 -0.817 1.00 1.00 C +ATOM 855 O4' G A 27 -7.101 -1.390 -1.151 1.00 1.00 O +ATOM 856 C3' G A 27 -7.660 -3.681 -1.208 1.00 1.00 C +ATOM 857 O3' G A 27 -7.640 -4.786 -0.292 1.00 1.00 O +ATOM 858 C2' G A 27 -8.949 -2.905 -1.013 1.00 1.00 C +ATOM 859 O2' G A 27 -9.547 -3.211 0.251 1.00 1.00 O +ATOM 860 C1' G A 27 -8.527 -1.439 -1.087 1.00 1.00 C +ATOM 861 N9 G A 27 -9.099 -0.705 -2.230 1.00 1.00 N +ATOM 862 C8 G A 27 -8.571 -0.445 -3.469 1.00 1.00 C +ATOM 863 N7 G A 27 -9.346 0.273 -4.233 1.00 1.00 N +ATOM 864 C5 G A 27 -10.470 0.506 -3.445 1.00 1.00 C +ATOM 865 C6 G A 27 -11.658 1.231 -3.740 1.00 1.00 C +ATOM 866 O6 G A 27 -11.951 1.828 -4.773 1.00 1.00 O +ATOM 867 N1 G A 27 -12.542 1.216 -2.669 1.00 1.00 N +ATOM 868 C2 G A 27 -12.316 0.585 -1.465 1.00 1.00 C +ATOM 869 N2 G A 27 -13.287 0.677 -0.558 1.00 1.00 N +ATOM 870 N3 G A 27 -11.201 -0.095 -1.186 1.00 1.00 N +ATOM 871 C4 G A 27 -10.327 -0.093 -2.219 1.00 1.00 C +ATOM 872 H5' G A 27 -4.503 -2.212 -1.031 1.00 1.00 H +ATOM 873 H5'' G A 27 -4.920 -3.900 -1.396 1.00 1.00 H +ATOM 874 H4' G A 27 -6.436 -2.719 0.258 1.00 1.00 H +ATOM 875 H3' G A 27 -7.542 -4.010 -2.243 1.00 1.00 H +ATOM 876 H2' G A 27 -9.643 -3.130 -1.827 1.00 1.00 H +ATOM 877 HO2' G A 27 -9.004 -2.801 0.931 1.00 1.00 H +ATOM 878 H1' G A 27 -8.841 -0.937 -0.174 1.00 1.00 H +ATOM 879 H8 G A 27 -7.595 -0.809 -3.788 1.00 1.00 H +ATOM 880 H1 G A 27 -13.411 1.715 -2.803 1.00 1.00 H +ATOM 881 H21 G A 27 -14.133 1.192 -0.772 1.00 1.00 H +ATOM 882 H22 G A 27 -13.179 0.234 0.342 1.00 1.00 H +ATOM 883 P G A 28 -8.551 -6.091 -0.548 1.00 1.00 P +ATOM 884 OP1 G A 28 -7.972 -7.215 0.223 1.00 1.00 O +ATOM 885 OP2 G A 28 -8.758 -6.230 -2.006 1.00 1.00 O +ATOM 886 O5' G A 28 -9.967 -5.694 0.128 1.00 1.00 O +ATOM 887 C5' G A 28 -10.155 -5.772 1.550 1.00 1.00 C +ATOM 888 C4' G A 28 -11.640 -5.845 1.927 1.00 1.00 C +ATOM 889 O4' G A 28 -12.200 -4.530 2.027 1.00 1.00 O +ATOM 890 C3' G A 28 -12.487 -6.622 0.931 1.00 1.00 C +ATOM 891 O3' G A 28 -12.629 -7.973 1.377 1.00 1.00 O +ATOM 892 C2' G A 28 -13.833 -5.911 0.965 1.00 1.00 C +ATOM 893 O2' G A 28 -14.711 -6.488 1.937 1.00 1.00 O +ATOM 894 C1' G A 28 -13.456 -4.483 1.329 1.00 1.00 C +ATOM 895 N9 G A 28 -13.259 -3.613 0.163 1.00 1.00 N +ATOM 896 C8 G A 28 -12.071 -3.142 -0.332 1.00 1.00 C +ATOM 897 N7 G A 28 -12.196 -2.419 -1.409 1.00 1.00 N +ATOM 898 C5 G A 28 -13.565 -2.408 -1.650 1.00 1.00 C +ATOM 899 C6 G A 28 -14.301 -1.778 -2.691 1.00 1.00 C +ATOM 900 O6 G A 28 -13.877 -1.099 -3.624 1.00 1.00 O +ATOM 901 N1 G A 28 -15.663 -2.015 -2.566 1.00 1.00 N +ATOM 902 C2 G A 28 -16.248 -2.762 -1.567 1.00 1.00 C +ATOM 903 N2 G A 28 -17.574 -2.876 -1.617 1.00 1.00 N +ATOM 904 N3 G A 28 -15.559 -3.355 -0.586 1.00 1.00 N +ATOM 905 C4 G A 28 -14.227 -3.135 -0.691 1.00 1.00 C +ATOM 906 H5' G A 28 -9.714 -4.890 2.014 1.00 1.00 H +ATOM 907 H5'' G A 28 -9.649 -6.661 1.927 1.00 1.00 H +ATOM 908 H4' G A 28 -11.725 -6.326 2.900 1.00 1.00 H +ATOM 909 H3' G A 28 -12.048 -6.577 -0.067 1.00 1.00 H +ATOM 910 H2' G A 28 -14.288 -5.929 -0.027 1.00 1.00 H +ATOM 911 HO2' G A 28 -15.604 -6.412 1.592 1.00 1.00 H +ATOM 912 H1' G A 28 -14.221 -4.054 1.976 1.00 1.00 H +ATOM 913 H8 G A 28 -11.108 -3.349 0.136 1.00 1.00 H +ATOM 914 H1 G A 28 -16.252 -1.599 -3.272 1.00 1.00 H +ATOM 915 H21 G A 28 -18.093 -2.426 -2.361 1.00 1.00 H +ATOM 916 H22 G A 28 -18.063 -3.411 -0.914 1.00 1.00 H +ATOM 917 P U A 29 -12.685 -9.180 0.316 1.00 1.00 P +ATOM 918 OP1 U A 29 -12.615 -10.456 1.064 1.00 1.00 O +ATOM 919 OP2 U A 29 -11.703 -8.899 -0.755 1.00 1.00 O +ATOM 920 O5' U A 29 -14.163 -9.040 -0.306 1.00 1.00 O +ATOM 921 C5' U A 29 -15.318 -9.331 0.486 1.00 1.00 C +ATOM 922 C4' U A 29 -16.602 -9.155 -0.318 1.00 1.00 C +ATOM 923 O4' U A 29 -16.805 -7.776 -0.621 1.00 1.00 O +ATOM 924 C3' U A 29 -16.605 -9.895 -1.644 1.00 1.00 C +ATOM 925 O3' U A 29 -17.121 -11.220 -1.460 1.00 1.00 O +ATOM 926 C2' U A 29 -17.548 -9.065 -2.493 1.00 1.00 C +ATOM 927 O2' U A 29 -18.906 -9.502 -2.358 1.00 1.00 O +ATOM 928 C1' U A 29 -17.356 -7.654 -1.942 1.00 1.00 C +ATOM 929 N1 U A 29 -16.420 -6.825 -2.729 1.00 1.00 N +ATOM 930 C2 U A 29 -16.943 -6.041 -3.739 1.00 1.00 C +ATOM 931 O2 U A 29 -18.144 -6.033 -4.006 1.00 1.00 O +ATOM 932 N3 U A 29 -16.036 -5.263 -4.436 1.00 1.00 N +ATOM 933 C4 U A 29 -14.671 -5.203 -4.214 1.00 1.00 C +ATOM 934 O4 U A 29 -13.956 -4.474 -4.897 1.00 1.00 O +ATOM 935 C5 U A 29 -14.212 -6.056 -3.140 1.00 1.00 C +ATOM 936 C6 U A 29 -15.082 -6.826 -2.443 1.00 1.00 C +ATOM 937 H5' U A 29 -15.341 -8.661 1.345 1.00 1.00 H +ATOM 938 H5'' U A 29 -15.258 -10.361 0.840 1.00 1.00 H +ATOM 939 H4' U A 29 -17.441 -9.501 0.281 1.00 1.00 H +ATOM 940 H3' U A 29 -15.604 -9.913 -2.079 1.00 1.00 H +ATOM 941 H2' U A 29 -17.235 -9.096 -3.534 1.00 1.00 H +ATOM 942 HO2' U A 29 -19.160 -9.363 -1.443 1.00 1.00 H +ATOM 943 H1' U A 29 -18.323 -7.154 -1.886 1.00 1.00 H +ATOM 944 H3 U A 29 -16.405 -4.684 -5.177 1.00 1.00 H +ATOM 945 H5 U A 29 -13.152 -6.078 -2.887 1.00 1.00 H +ATOM 946 H6 U A 29 -14.708 -7.459 -1.638 1.00 1.00 H +ATOM 947 P U A 30 -16.639 -12.432 -2.410 1.00 1.00 P +ATOM 948 OP1 U A 30 -17.142 -13.698 -1.830 1.00 1.00 O +ATOM 949 OP2 U A 30 -15.191 -12.267 -2.668 1.00 1.00 O +ATOM 950 O5' U A 30 -17.429 -12.162 -3.789 1.00 1.00 O +ATOM 951 C5' U A 30 -18.847 -12.346 -3.861 1.00 1.00 C +ATOM 952 C4' U A 30 -19.414 -11.853 -5.192 1.00 1.00 C +ATOM 953 O4' U A 30 -19.209 -10.448 -5.316 1.00 1.00 O +ATOM 954 C3' U A 30 -18.784 -12.483 -6.424 1.00 1.00 C +ATOM 955 O3' U A 30 -19.466 -13.698 -6.760 1.00 1.00 O +ATOM 956 C2' U A 30 -19.029 -11.431 -7.491 1.00 1.00 C +ATOM 957 O2' U A 30 -20.303 -11.606 -8.121 1.00 1.00 O +ATOM 958 C1' U A 30 -18.974 -10.128 -6.696 1.00 1.00 C +ATOM 959 N1 U A 30 -17.669 -9.444 -6.772 1.00 1.00 N +ATOM 960 C2 U A 30 -17.526 -8.446 -7.718 1.00 1.00 C +ATOM 961 O2 U A 30 -18.434 -8.144 -8.490 1.00 1.00 O +ATOM 962 N3 U A 30 -16.301 -7.807 -7.746 1.00 1.00 N +ATOM 963 C4 U A 30 -15.220 -8.074 -6.924 1.00 1.00 C +ATOM 964 O4 U A 30 -14.173 -7.440 -7.036 1.00 1.00 O +ATOM 965 C5 U A 30 -15.457 -9.131 -5.965 1.00 1.00 C +ATOM 966 C6 U A 30 -16.650 -9.773 -5.919 1.00 1.00 C +ATOM 967 H5' U A 30 -19.319 -11.793 -3.049 1.00 1.00 H +ATOM 968 H5'' U A 30 -19.073 -13.405 -3.750 1.00 1.00 H +ATOM 969 H4' U A 30 -20.485 -12.044 -5.209 1.00 1.00 H +ATOM 970 H3' U A 30 -17.715 -12.649 -6.275 1.00 1.00 H +ATOM 971 H2' U A 30 -18.227 -11.450 -8.228 1.00 1.00 H +ATOM 972 HO2' U A 30 -20.967 -11.250 -7.528 1.00 1.00 H +ATOM 973 H1' U A 30 -19.756 -9.455 -7.046 1.00 1.00 H +ATOM 974 H3 U A 30 -16.182 -7.075 -8.433 1.00 1.00 H +ATOM 975 H5 U A 30 -14.666 -9.417 -5.272 1.00 1.00 H +ATOM 976 H6 U A 30 -16.802 -10.565 -5.185 1.00 1.00 H +ATOM 977 P C A 31 -18.699 -14.889 -7.531 1.00 1.00 P +ATOM 978 OP1 C A 31 -19.683 -15.956 -7.821 1.00 1.00 O +ATOM 979 OP2 C A 31 -17.466 -15.210 -6.778 1.00 1.00 O +ATOM 980 O5' C A 31 -18.273 -14.208 -8.928 1.00 1.00 O +ATOM 981 C5' C A 31 -19.252 -13.938 -9.936 1.00 1.00 C +ATOM 982 C4' C A 31 -18.670 -13.120 -11.083 1.00 1.00 C +ATOM 983 O4' C A 31 -18.287 -11.836 -10.618 1.00 1.00 O +ATOM 984 C3' C A 31 -17.429 -13.712 -11.716 1.00 1.00 C +ATOM 985 O3' C A 31 -17.802 -14.684 -12.701 1.00 1.00 O +ATOM 986 C2' C A 31 -16.807 -12.490 -12.382 1.00 1.00 C +ATOM 987 O2' C A 31 -17.309 -12.309 -13.711 1.00 1.00 O +ATOM 988 C1' C A 31 -17.231 -11.339 -11.457 1.00 1.00 C +ATOM 989 N1 C A 31 -16.153 -10.854 -10.571 1.00 1.00 N +ATOM 990 C2 C A 31 -15.468 -9.713 -10.961 1.00 1.00 C +ATOM 991 O2 C A 31 -15.749 -9.159 -12.021 1.00 1.00 O +ATOM 992 N3 C A 31 -14.491 -9.235 -10.142 1.00 1.00 N +ATOM 993 C4 C A 31 -14.196 -9.852 -8.990 1.00 1.00 C +ATOM 994 N4 C A 31 -13.232 -9.357 -8.212 1.00 1.00 N +ATOM 995 C5 C A 31 -14.900 -11.029 -8.583 1.00 1.00 C +ATOM 996 C6 C A 31 -15.868 -11.493 -9.399 1.00 1.00 C +ATOM 997 H5' C A 31 -20.078 -13.383 -9.489 1.00 1.00 H +ATOM 998 H5'' C A 31 -19.628 -14.882 -10.328 1.00 1.00 H +ATOM 999 H4' C A 31 -19.432 -12.994 -11.851 1.00 1.00 H +ATOM 1000 H3' C A 31 -16.764 -14.131 -10.959 1.00 1.00 H +ATOM 1001 H2' C A 31 -15.724 -12.577 -12.389 1.00 1.00 H +ATOM 1002 HO2' C A 31 -17.715 -11.441 -13.749 1.00 1.00 H +ATOM 1003 H1' C A 31 -17.609 -10.507 -12.055 1.00 1.00 H +ATOM 1004 H41 C A 31 -12.731 -8.521 -8.501 1.00 1.00 H +ATOM 1005 H42 C A 31 -12.999 -9.811 -7.342 1.00 1.00 H +ATOM 1006 H5 C A 31 -14.664 -11.532 -7.645 1.00 1.00 H +ATOM 1007 H6 C A 31 -16.426 -12.387 -9.122 1.00 1.00 H +ATOM 1008 P U A 32 -17.131 -16.149 -12.708 1.00 1.00 P +ATOM 1009 OP1 U A 32 -18.052 -17.072 -13.411 1.00 1.00 O +ATOM 1010 OP2 U A 32 -16.689 -16.462 -11.331 1.00 1.00 O +ATOM 1011 O5' U A 32 -15.820 -15.951 -13.622 1.00 1.00 O +ATOM 1012 C5' U A 32 -15.926 -15.363 -14.918 1.00 1.00 C +ATOM 1013 C4' U A 32 -14.807 -14.356 -15.175 1.00 1.00 C +ATOM 1014 O4' U A 32 -14.778 -13.373 -14.145 1.00 1.00 O +ATOM 1015 C3' U A 32 -13.405 -14.946 -15.215 1.00 1.00 C +ATOM 1016 O3' U A 32 -13.103 -15.391 -16.544 1.00 1.00 O +ATOM 1017 C2' U A 32 -12.523 -13.761 -14.858 1.00 1.00 C +ATOM 1018 O2' U A 32 -12.002 -13.122 -16.028 1.00 1.00 O +ATOM 1019 C1' U A 32 -13.450 -12.830 -14.077 1.00 1.00 C +ATOM 1020 N1 U A 32 -13.070 -12.666 -12.655 1.00 1.00 N +ATOM 1021 C2 U A 32 -12.282 -11.577 -12.334 1.00 1.00 C +ATOM 1022 O2 U A 32 -11.889 -10.781 -13.185 1.00 1.00 O +ATOM 1023 N3 U A 32 -11.955 -11.435 -10.999 1.00 1.00 N +ATOM 1024 C4 U A 32 -12.343 -12.277 -9.970 1.00 1.00 C +ATOM 1025 O4 U A 32 -11.995 -12.054 -8.812 1.00 1.00 O +ATOM 1026 C5 U A 32 -13.165 -13.388 -10.395 1.00 1.00 C +ATOM 1027 C6 U A 32 -13.498 -13.547 -11.698 1.00 1.00 C +ATOM 1028 H5' U A 32 -16.888 -14.853 -14.999 1.00 1.00 H +ATOM 1029 H5'' U A 32 -15.876 -16.149 -15.669 1.00 1.00 H +ATOM 1030 H4' U A 32 -15.000 -13.852 -16.120 1.00 1.00 H +ATOM 1031 H3' U A 32 -13.298 -15.752 -14.485 1.00 1.00 H +ATOM 1032 H2' U A 32 -11.717 -14.089 -14.209 1.00 1.00 H +ATOM 1033 HO2' U A 32 -12.696 -12.555 -16.378 1.00 1.00 H +ATOM 1034 H1' U A 32 -13.451 -11.853 -14.561 1.00 1.00 H +ATOM 1035 H3 U A 32 -11.379 -10.644 -10.749 1.00 1.00 H +ATOM 1036 H5 U A 32 -13.520 -14.108 -9.658 1.00 1.00 H +ATOM 1037 H6 U A 32 -14.118 -14.394 -11.992 1.00 1.00 H +ATOM 1038 P U A 33 -11.887 -16.413 -16.819 1.00 1.00 P +ATOM 1039 OP1 U A 33 -11.941 -16.819 -18.242 1.00 1.00 O +ATOM 1040 OP2 U A 33 -11.903 -17.444 -15.759 1.00 1.00 O +ATOM 1041 O5' U A 33 -10.579 -15.493 -16.608 1.00 1.00 O +ATOM 1042 C5' U A 33 -10.310 -14.398 -17.492 1.00 1.00 C +ATOM 1043 C4' U A 33 -9.145 -13.538 -16.999 1.00 1.00 C +ATOM 1044 O4' U A 33 -9.470 -12.953 -15.747 1.00 1.00 O +ATOM 1045 C3' U A 33 -7.842 -14.287 -16.781 1.00 1.00 C +ATOM 1046 O3' U A 33 -7.086 -14.295 -17.996 1.00 1.00 O +ATOM 1047 C2' U A 33 -7.124 -13.452 -15.727 1.00 1.00 C +ATOM 1048 O2' U A 33 -6.197 -12.539 -16.324 1.00 1.00 O +ATOM 1049 C1' U A 33 -8.259 -12.709 -15.015 1.00 1.00 C +ATOM 1050 N1 U A 33 -8.482 -13.147 -13.621 1.00 1.00 N +ATOM 1051 C2 U A 33 -7.912 -12.390 -12.615 1.00 1.00 C +ATOM 1052 O2 U A 33 -7.232 -11.394 -12.850 1.00 1.00 O +ATOM 1053 N3 U A 33 -8.150 -12.821 -11.322 1.00 1.00 N +ATOM 1054 C4 U A 33 -8.900 -13.925 -10.953 1.00 1.00 C +ATOM 1055 O4 U A 33 -9.047 -14.216 -9.768 1.00 1.00 O +ATOM 1056 C5 U A 33 -9.458 -14.655 -12.069 1.00 1.00 C +ATOM 1057 C6 U A 33 -9.237 -14.253 -13.344 1.00 1.00 C +ATOM 1058 H5' U A 33 -11.202 -13.776 -17.567 1.00 1.00 H +ATOM 1059 H5'' U A 33 -10.068 -14.791 -18.478 1.00 1.00 H +ATOM 1060 H4' U A 33 -8.974 -12.736 -17.714 1.00 1.00 H +ATOM 1061 H3' U A 33 -8.030 -15.299 -16.421 1.00 1.00 H +ATOM 1062 H2' U A 33 -6.613 -14.113 -15.021 1.00 1.00 H +ATOM 1063 HO2' U A 33 -6.564 -12.269 -17.168 1.00 1.00 H +ATOM 1064 H1' U A 33 -8.045 -11.640 -15.030 1.00 1.00 H +ATOM 1065 H3 U A 33 -7.740 -12.278 -10.575 1.00 1.00 H +ATOM 1066 H5 U A 33 -10.065 -15.542 -11.882 1.00 1.00 H +ATOM 1067 H6 U A 33 -9.670 -14.824 -14.166 1.00 1.00 H +ATOM 1068 P C A 34 -5.792 -15.238 -18.142 1.00 1.00 P +ATOM 1069 OP1 C A 34 -5.112 -14.896 -19.411 1.00 1.00 O +ATOM 1070 OP2 C A 34 -6.203 -16.634 -17.877 1.00 1.00 O +ATOM 1071 O5' C A 34 -4.864 -14.741 -16.923 1.00 1.00 O +ATOM 1072 C5' C A 34 -4.430 -15.662 -15.918 1.00 1.00 C +ATOM 1073 C4' C A 34 -3.419 -15.023 -14.970 1.00 1.00 C +ATOM 1074 O4' C A 34 -4.101 -14.247 -13.985 1.00 1.00 O +ATOM 1075 C3' C A 34 -2.561 -16.025 -14.217 1.00 1.00 C +ATOM 1076 O3' C A 34 -1.338 -16.234 -14.930 1.00 1.00 O +ATOM 1077 C2' C A 34 -2.266 -15.342 -12.889 1.00 1.00 C +ATOM 1078 O2' C A 34 -0.976 -14.719 -12.903 1.00 1.00 O +ATOM 1079 C1' C A 34 -3.381 -14.306 -12.744 1.00 1.00 C +ATOM 1080 N1 C A 34 -4.351 -14.616 -11.676 1.00 1.00 N +ATOM 1081 C2 C A 34 -4.016 -14.252 -10.383 1.00 1.00 C +ATOM 1082 O2 C A 34 -2.943 -13.697 -10.158 1.00 1.00 O +ATOM 1083 N3 C A 34 -4.902 -14.524 -9.385 1.00 1.00 N +ATOM 1084 C4 C A 34 -6.068 -15.129 -9.648 1.00 1.00 C +ATOM 1085 N4 C A 34 -6.913 -15.381 -8.648 1.00 1.00 N +ATOM 1086 C5 C A 34 -6.418 -15.507 -10.983 1.00 1.00 C +ATOM 1087 C6 C A 34 -5.535 -15.233 -11.962 1.00 1.00 C +ATOM 1088 H5' C A 34 -3.968 -16.522 -16.401 1.00 1.00 H +ATOM 1089 H5'' C A 34 -5.294 -15.996 -15.345 1.00 1.00 H +ATOM 1090 H4' C A 34 -2.770 -14.360 -15.540 1.00 1.00 H +ATOM 1091 H3' C A 34 -3.098 -16.962 -14.065 1.00 1.00 H +ATOM 1092 H2' C A 34 -2.330 -16.070 -12.077 1.00 1.00 H +ATOM 1093 HO2' C A 34 -0.426 -15.219 -13.511 1.00 1.00 H +ATOM 1094 H1' C A 34 -2.936 -13.332 -12.545 1.00 1.00 H +ATOM 1095 H41 C A 34 -6.671 -15.117 -7.705 1.00 1.00 H +ATOM 1096 H42 C A 34 -7.796 -15.837 -8.836 1.00 1.00 H +ATOM 1097 H5 C A 34 -7.367 -15.998 -11.200 1.00 1.00 H +ATOM 1098 H6 C A 34 -5.768 -15.505 -12.992 1.00 1.00 H +ATOM 1099 P C A 35 -0.327 -17.403 -14.488 1.00 1.00 P +ATOM 1100 OP1 C A 35 0.891 -17.302 -15.323 1.00 1.00 O +ATOM 1101 OP2 C A 35 -1.082 -18.674 -14.432 1.00 1.00 O +ATOM 1102 O5' C A 35 0.059 -16.978 -12.985 1.00 1.00 O +ATOM 1103 C5' C A 35 0.184 -17.969 -11.963 1.00 1.00 C +ATOM 1104 C4' C A 35 0.850 -17.404 -10.714 1.00 1.00 C +ATOM 1105 O4' C A 35 -0.032 -16.491 -10.064 1.00 1.00 O +ATOM 1106 C3' C A 35 1.226 -18.461 -9.691 1.00 1.00 C +ATOM 1107 O3' C A 35 2.579 -18.870 -9.910 1.00 1.00 O +ATOM 1108 C2' C A 35 1.106 -17.740 -8.358 1.00 1.00 C +ATOM 1109 O2' C A 35 2.370 -17.219 -7.933 1.00 1.00 O +ATOM 1110 C1' C A 35 0.108 -16.617 -8.643 1.00 1.00 C +ATOM 1111 N1 C A 35 -1.236 -16.857 -8.089 1.00 1.00 N +ATOM 1112 C2 C A 35 -1.434 -16.561 -6.751 1.00 1.00 C +ATOM 1113 O2 C A 35 -0.508 -16.123 -6.073 1.00 1.00 O +ATOM 1114 N3 C A 35 -2.671 -16.771 -6.220 1.00 1.00 N +ATOM 1115 C4 C A 35 -3.670 -17.251 -6.973 1.00 1.00 C +ATOM 1116 N4 C A 35 -4.869 -17.444 -6.423 1.00 1.00 N +ATOM 1117 C5 C A 35 -3.468 -17.558 -8.356 1.00 1.00 C +ATOM 1118 C6 C A 35 -2.242 -17.347 -8.871 1.00 1.00 C +ATOM 1119 H5' C A 35 0.781 -18.797 -12.342 1.00 1.00 H +ATOM 1120 H5'' C A 35 -0.809 -18.337 -11.702 1.00 1.00 H +ATOM 1121 H4' C A 35 1.748 -16.865 -11.008 1.00 1.00 H +ATOM 1122 H3' C A 35 0.541 -19.308 -9.738 1.00 1.00 H +ATOM 1123 H2' C A 35 0.696 -18.418 -7.605 1.00 1.00 H +ATOM 1124 HO2' C A 35 2.907 -17.965 -7.656 1.00 1.00 H +ATOM 1125 H1' C A 35 0.497 -15.683 -8.236 1.00 1.00 H +ATOM 1126 H41 C A 35 -5.017 -17.229 -5.445 1.00 1.00 H +ATOM 1127 H42 C A 35 -5.628 -17.806 -6.981 1.00 1.00 H +ATOM 1128 H5 C A 35 -4.278 -17.950 -8.970 1.00 1.00 H +ATOM 1129 H6 C A 35 -2.051 -17.570 -9.920 1.00 1.00 H +ATOM 1130 P U A 36 3.065 -20.345 -9.487 1.00 1.00 P +ATOM 1131 OP1 U A 36 4.414 -20.568 -10.052 1.00 1.00 O +ATOM 1132 OP2 U A 36 1.972 -21.296 -9.786 1.00 1.00 O +ATOM 1133 O5' U A 36 3.201 -20.221 -7.889 1.00 1.00 O +ATOM 1134 C5' U A 36 2.874 -21.326 -7.046 1.00 1.00 C +ATOM 1135 C4' U A 36 2.873 -20.922 -5.578 1.00 1.00 C +ATOM 1136 O4' U A 36 1.811 -19.999 -5.334 1.00 1.00 O +ATOM 1137 C3' U A 36 2.677 -22.085 -4.613 1.00 1.00 C +ATOM 1138 O3' U A 36 3.951 -22.578 -4.179 1.00 1.00 O +ATOM 1139 C2' U A 36 1.937 -21.470 -3.436 1.00 1.00 C +ATOM 1140 O2' U A 36 2.829 -21.188 -2.354 1.00 1.00 O +ATOM 1141 C1' U A 36 1.330 -20.187 -4.001 1.00 1.00 C +ATOM 1142 N1 U A 36 -0.146 -20.194 -4.037 1.00 1.00 N +ATOM 1143 C2 U A 36 -0.789 -20.320 -2.821 1.00 1.00 C +ATOM 1144 O2 U A 36 -0.172 -20.449 -1.765 1.00 1.00 O +ATOM 1145 N3 U A 36 -2.172 -20.296 -2.859 1.00 1.00 N +ATOM 1146 C4 U A 36 -2.955 -20.158 -3.991 1.00 1.00 C +ATOM 1147 O4 U A 36 -4.181 -20.147 -3.908 1.00 1.00 O +ATOM 1148 C5 U A 36 -2.199 -20.032 -5.218 1.00 1.00 C +ATOM 1149 C6 U A 36 -0.844 -20.054 -5.205 1.00 1.00 C +ATOM 1150 H5' U A 36 3.605 -22.119 -7.198 1.00 1.00 H +ATOM 1151 H5'' U A 36 1.884 -21.698 -7.314 1.00 1.00 H +ATOM 1152 H4' U A 36 3.816 -20.430 -5.348 1.00 1.00 H +ATOM 1153 H3' U A 36 2.083 -22.875 -5.074 1.00 1.00 H +ATOM 1154 H2' U A 36 1.142 -22.140 -3.110 1.00 1.00 H +ATOM 1155 HO2' U A 36 2.379 -21.438 -1.543 1.00 1.00 H +ATOM 1156 H1' U A 36 1.657 -19.347 -3.389 1.00 1.00 H +ATOM 1157 H3 U A 36 -2.654 -20.386 -1.976 1.00 1.00 H +ATOM 1158 H5 U A 36 -2.726 -19.918 -6.165 1.00 1.00 H +ATOM 1159 H6 U A 36 -0.300 -19.959 -6.145 1.00 1.00 H +ATOM 1160 P A A 37 4.106 -24.083 -3.619 1.00 1.00 P +ATOM 1161 OP1 A A 37 5.546 -24.359 -3.422 1.00 1.00 O +ATOM 1162 OP2 A A 37 3.295 -24.977 -4.475 1.00 1.00 O +ATOM 1163 O5' A A 37 3.406 -24.007 -2.168 1.00 1.00 O +ATOM 1164 C5' A A 37 3.955 -23.181 -1.136 1.00 1.00 C +ATOM 1165 C4' A A 37 3.079 -23.184 0.117 1.00 1.00 C +ATOM 1166 O4' A A 37 1.738 -22.839 -0.243 1.00 1.00 O +ATOM 1167 C3' A A 37 3.028 -24.528 0.843 1.00 1.00 C +ATOM 1168 O3' A A 37 3.015 -24.300 2.258 1.00 1.00 O +ATOM 1169 C2' A A 37 1.703 -25.139 0.413 1.00 1.00 C +ATOM 1170 O2' A A 37 1.104 -25.889 1.475 1.00 1.00 O +ATOM 1171 C1' A A 37 0.854 -23.929 0.048 1.00 1.00 C +ATOM 1172 N9 A A 37 -0.002 -24.140 -1.134 1.00 1.00 N +ATOM 1173 C8 A A 37 0.365 -24.486 -2.409 1.00 1.00 C +ATOM 1174 N7 A A 37 -0.639 -24.599 -3.235 1.00 1.00 N +ATOM 1175 C5 A A 37 -1.749 -24.306 -2.450 1.00 1.00 C +ATOM 1176 C6 A A 37 -3.124 -24.252 -2.734 1.00 1.00 C +ATOM 1177 N6 A A 37 -3.631 -24.503 -3.942 1.00 1.00 N +ATOM 1178 N1 A A 37 -3.950 -23.931 -1.724 1.00 1.00 N +ATOM 1179 C2 A A 37 -3.440 -23.683 -0.524 1.00 1.00 C +ATOM 1180 N3 A A 37 -2.174 -23.701 -0.134 1.00 1.00 N +ATOM 1181 C4 A A 37 -1.371 -24.027 -1.168 1.00 1.00 C +ATOM 1182 H5' A A 37 4.045 -22.160 -1.505 1.00 1.00 H +ATOM 1183 H5'' A A 37 4.947 -23.552 -0.879 1.00 1.00 H +ATOM 1184 H4' A A 37 3.453 -22.429 0.806 1.00 1.00 H +ATOM 1185 H3' A A 37 3.866 -25.163 0.551 1.00 1.00 H +ATOM 1186 H2' A A 37 1.853 -25.768 -0.467 1.00 1.00 H +ATOM 1187 HO2' A A 37 1.809 -26.368 1.919 1.00 1.00 H +ATOM 1188 H1' A A 37 0.226 -23.664 0.898 1.00 1.00 H +ATOM 1189 H8 A A 37 1.401 -24.651 -2.706 1.00 1.00 H +ATOM 1190 H61 A A 37 -4.629 -24.450 -4.092 1.00 1.00 H +ATOM 1191 H62 A A 37 -3.018 -24.745 -4.706 1.00 1.00 H +ATOM 1192 H2 A A 37 -4.165 -23.429 0.249 1.00 1.00 H +ATOM 1193 P A A 38 3.434 -25.466 3.290 1.00 1.00 P +ATOM 1194 OP1 A A 38 4.910 -25.496 3.378 1.00 1.00 O +ATOM 1195 OP2 A A 38 2.690 -26.694 2.934 1.00 1.00 O +ATOM 1196 O5' A A 38 2.858 -24.915 4.692 1.00 1.00 O +ATOM 1197 C5' A A 38 3.739 -24.346 5.664 1.00 1.00 C +ATOM 1198 C4' A A 38 2.984 -23.501 6.688 1.00 1.00 C +ATOM 1199 O4' A A 38 2.419 -22.359 6.036 1.00 1.00 O +ATOM 1200 C3' A A 38 1.846 -24.242 7.385 1.00 1.00 C +ATOM 1201 O3' A A 38 2.278 -24.674 8.679 1.00 1.00 O +ATOM 1202 C2' A A 38 0.757 -23.193 7.541 1.00 1.00 C +ATOM 1203 O2' A A 38 0.821 -22.564 8.826 1.00 1.00 O +ATOM 1204 C1' A A 38 1.049 -22.200 6.424 1.00 1.00 C +ATOM 1205 N9 A A 38 0.217 -22.394 5.222 1.00 1.00 N +ATOM 1206 C8 A A 38 0.572 -22.910 4.002 1.00 1.00 C +ATOM 1207 N7 A A 38 -0.407 -22.952 3.141 1.00 1.00 N +ATOM 1208 C5 A A 38 -1.489 -22.426 3.842 1.00 1.00 C +ATOM 1209 C6 A A 38 -2.829 -22.197 3.489 1.00 1.00 C +ATOM 1210 N6 A A 38 -3.328 -22.486 2.287 1.00 1.00 N +ATOM 1211 N1 A A 38 -3.630 -21.663 4.426 1.00 1.00 N +ATOM 1212 C2 A A 38 -3.130 -21.379 5.623 1.00 1.00 C +ATOM 1213 N3 A A 38 -1.896 -21.546 6.072 1.00 1.00 N +ATOM 1214 C4 A A 38 -1.117 -22.084 5.112 1.00 1.00 C +ATOM 1215 H5' A A 38 4.471 -23.717 5.156 1.00 1.00 H +ATOM 1216 H5'' A A 38 4.261 -25.150 6.183 1.00 1.00 H +ATOM 1217 H4' A A 38 3.687 -23.152 7.441 1.00 1.00 H +ATOM 1218 H3' A A 38 1.497 -25.081 6.781 1.00 1.00 H +ATOM 1219 H2' A A 38 -0.223 -23.650 7.385 1.00 1.00 H +ATOM 1220 HO2' A A 38 1.400 -21.803 8.742 1.00 1.00 H +ATOM 1221 H1' A A 38 0.900 -21.188 6.798 1.00 1.00 H +ATOM 1222 H8 A A 38 1.582 -23.253 3.772 1.00 1.00 H +ATOM 1223 H61 A A 38 -4.299 -22.301 2.084 1.00 1.00 H +ATOM 1224 H62 A A 38 -2.732 -22.887 1.576 1.00 1.00 H +ATOM 1225 H2 A A 38 -3.835 -20.948 6.334 1.00 1.00 H +ATOM 1226 P G A 39 1.447 -25.789 9.493 1.00 1.00 P +ATOM 1227 OP1 G A 39 2.350 -26.398 10.495 1.00 1.00 O +ATOM 1228 OP2 G A 39 0.747 -26.649 8.513 1.00 1.00 O +ATOM 1229 O5' G A 39 0.342 -24.913 10.274 1.00 1.00 O +ATOM 1230 C5' G A 39 -0.797 -25.547 10.866 1.00 1.00 C +ATOM 1231 C4' G A 39 -2.015 -24.621 10.879 1.00 1.00 C +ATOM 1232 O4' G A 39 -2.035 -23.839 9.682 1.00 1.00 O +ATOM 1233 C3' G A 39 -3.354 -25.355 10.980 1.00 1.00 C +ATOM 1234 O3' G A 39 -3.864 -25.248 12.313 1.00 1.00 O +ATOM 1235 C2' G A 39 -4.263 -24.602 10.021 1.00 1.00 C +ATOM 1236 O2' G A 39 -5.005 -23.581 10.696 1.00 1.00 O +ATOM 1237 C1' G A 39 -3.290 -24.007 9.015 1.00 1.00 C +ATOM 1238 N9 G A 39 -3.052 -24.856 7.835 1.00 1.00 N +ATOM 1239 C8 G A 39 -1.945 -25.605 7.529 1.00 1.00 C +ATOM 1240 N7 G A 39 -2.042 -26.258 6.404 1.00 1.00 N +ATOM 1241 C5 G A 39 -3.305 -25.918 5.927 1.00 1.00 C +ATOM 1242 C6 G A 39 -3.970 -26.325 4.738 1.00 1.00 C +ATOM 1243 O6 G A 39 -3.565 -27.080 3.857 1.00 1.00 O +ATOM 1244 N1 G A 39 -5.230 -25.751 4.638 1.00 1.00 N +ATOM 1245 C2 G A 39 -5.785 -24.894 5.563 1.00 1.00 C +ATOM 1246 N2 G A 39 -7.009 -24.443 5.291 1.00 1.00 N +ATOM 1247 N3 G A 39 -5.162 -24.510 6.683 1.00 1.00 N +ATOM 1248 C4 G A 39 -3.931 -25.059 6.797 1.00 1.00 C +ATOM 1249 H5' G A 39 -0.552 -25.828 11.890 1.00 1.00 H +ATOM 1250 H5'' G A 39 -1.035 -26.446 10.298 1.00 1.00 H +ATOM 1251 H4' G A 39 -1.926 -23.944 11.727 1.00 1.00 H +ATOM 1252 H3' G A 39 -3.254 -26.398 10.679 1.00 1.00 H +ATOM 1253 H2' G A 39 -4.936 -25.300 9.518 1.00 1.00 H +ATOM 1254 HO2' G A 39 -5.324 -22.971 10.028 1.00 1.00 H +ATOM 1255 H1' G A 39 -3.657 -23.035 8.688 1.00 1.00 H +ATOM 1256 H8 G A 39 -1.062 -25.650 8.166 1.00 1.00 H +ATOM 1257 H1 G A 39 -5.765 -25.994 3.816 1.00 1.00 H +ATOM 1258 H21 G A 39 -7.478 -24.735 4.446 1.00 1.00 H +ATOM 1259 H22 G A 39 -7.469 -23.812 5.932 1.00 1.00 H +ATOM 1260 P U A 40 -4.407 -26.554 13.086 1.00 1.00 P +ATOM 1261 OP1 U A 40 -4.826 -26.147 14.445 1.00 1.00 O +ATOM 1262 OP2 U A 40 -3.412 -27.637 12.916 1.00 1.00 O +ATOM 1263 O5' U A 40 -5.725 -26.949 12.249 1.00 1.00 O +ATOM 1264 C5' U A 40 -6.983 -26.329 12.531 1.00 1.00 C +ATOM 1265 C4' U A 40 -8.100 -26.903 11.664 1.00 1.00 C +ATOM 1266 O4' U A 40 -7.892 -26.534 10.300 1.00 1.00 O +ATOM 1267 C3' U A 40 -8.193 -28.421 11.704 1.00 1.00 C +ATOM 1268 O3' U A 40 -9.120 -28.818 12.724 1.00 1.00 O +ATOM 1269 C2' U A 40 -8.737 -28.775 10.331 1.00 1.00 C +ATOM 1270 O2' U A 40 -10.167 -28.822 10.333 1.00 1.00 O +ATOM 1271 C1' U A 40 -8.215 -27.644 9.447 1.00 1.00 C +ATOM 1272 N1 U A 40 -6.992 -27.988 8.693 1.00 1.00 N +ATOM 1273 C2 U A 40 -7.148 -28.532 7.432 1.00 1.00 C +ATOM 1274 O2 U A 40 -8.256 -28.742 6.943 1.00 1.00 O +ATOM 1275 N3 U A 40 -5.982 -28.826 6.750 1.00 1.00 N +ATOM 1276 C4 U A 40 -4.692 -28.628 7.212 1.00 1.00 C +ATOM 1277 O4 U A 40 -3.724 -28.928 6.517 1.00 1.00 O +ATOM 1278 C5 U A 40 -4.625 -28.056 8.539 1.00 1.00 C +ATOM 1279 C6 U A 40 -5.754 -27.759 9.226 1.00 1.00 C +ATOM 1280 H5' U A 40 -6.903 -25.258 12.343 1.00 1.00 H +ATOM 1281 H5'' U A 40 -7.231 -26.489 13.581 1.00 1.00 H +ATOM 1282 H4' U A 40 -9.049 -26.485 11.992 1.00 1.00 H +ATOM 1283 H3' U A 40 -7.210 -28.867 11.862 1.00 1.00 H +ATOM 1284 H2' U A 40 -8.319 -29.724 9.998 1.00 1.00 H +ATOM 1285 HO2' U A 40 -10.422 -29.696 10.638 1.00 1.00 H +ATOM 1286 H1' U A 40 -8.996 -27.342 8.748 1.00 1.00 H +ATOM 1287 H3 U A 40 -6.081 -29.223 5.826 1.00 1.00 H +ATOM 1288 H5 U A 40 -3.653 -27.861 8.992 1.00 1.00 H +ATOM 1289 H6 U A 40 -5.673 -27.328 10.224 1.00 1.00 H +ATOM 1290 P C A 41 -8.858 -30.138 13.612 1.00 1.00 P +ATOM 1291 OP1 C A 41 -9.868 -30.175 14.692 1.00 1.00 O +ATOM 1292 OP2 C A 41 -7.418 -30.189 13.949 1.00 1.00 O +ATOM 1293 O5' C A 41 -9.176 -31.340 12.585 1.00 1.00 O +ATOM 1294 C5' C A 41 -10.526 -31.745 12.335 1.00 1.00 C +ATOM 1295 C4' C A 41 -10.608 -32.731 11.174 1.00 1.00 C +ATOM 1296 O4' C A 41 -10.013 -32.160 10.010 1.00 1.00 O +ATOM 1297 C3' C A 41 -9.898 -34.051 11.423 1.00 1.00 C +ATOM 1298 O3' C A 41 -10.812 -34.991 12.006 1.00 1.00 O +ATOM 1299 C2' C A 41 -9.499 -34.498 10.026 1.00 1.00 C +ATOM 1300 O2' C A 41 -10.511 -35.320 9.433 1.00 1.00 O +ATOM 1301 C1' C A 41 -9.328 -33.182 9.270 1.00 1.00 C +ATOM 1302 N1 C A 41 -7.919 -32.756 9.130 1.00 1.00 N +ATOM 1303 C2 C A 41 -7.256 -33.082 7.957 1.00 1.00 C +ATOM 1304 O2 C A 41 -7.839 -33.710 7.076 1.00 1.00 O +ATOM 1305 N3 C A 41 -5.960 -32.688 7.817 1.00 1.00 N +ATOM 1306 C4 C A 41 -5.339 -32.006 8.788 1.00 1.00 C +ATOM 1307 N4 C A 41 -4.069 -31.636 8.620 1.00 1.00 N +ATOM 1308 C5 C A 41 -6.019 -31.667 10.000 1.00 1.00 C +ATOM 1309 C6 C A 41 -7.301 -32.060 10.129 1.00 1.00 C +ATOM 1310 H5' C A 41 -11.125 -30.866 12.098 1.00 1.00 H +ATOM 1311 H5'' C A 41 -10.926 -32.217 13.232 1.00 1.00 H +ATOM 1312 H4' C A 41 -11.655 -32.932 10.958 1.00 1.00 H +ATOM 1313 H3' C A 41 -9.018 -33.906 12.053 1.00 1.00 H +ATOM 1314 H2' C A 41 -8.548 -35.024 10.063 1.00 1.00 H +ATOM 1315 HO2' C A 41 -11.018 -34.764 8.837 1.00 1.00 H +ATOM 1316 H1' C A 41 -9.778 -33.271 8.281 1.00 1.00 H +ATOM 1317 H41 C A 41 -3.586 -31.870 7.770 1.00 1.00 H +ATOM 1318 H42 C A 41 -3.593 -31.120 9.345 1.00 1.00 H +ATOM 1319 H5 C A 41 -5.517 -31.112 10.792 1.00 1.00 H +ATOM 1320 H6 C A 41 -7.850 -31.821 11.040 1.00 1.00 H +ATOM 1321 P C A 42 -10.286 -36.170 12.975 1.00 1.00 P +ATOM 1322 OP1 C A 42 -11.466 -36.828 13.580 1.00 1.00 O +ATOM 1323 OP2 C A 42 -9.228 -35.613 13.847 1.00 1.00 O +ATOM 1324 O5' C A 42 -9.600 -37.213 11.955 1.00 1.00 O +ATOM 1325 C5' C A 42 -10.408 -38.040 11.110 1.00 1.00 C +ATOM 1326 C4' C A 42 -9.575 -38.753 10.047 1.00 1.00 C +ATOM 1327 O4' C A 42 -8.805 -37.803 9.318 1.00 1.00 O +ATOM 1328 C3' C A 42 -8.580 -39.768 10.588 1.00 1.00 C +ATOM 1329 O3' C A 42 -9.191 -41.059 10.695 1.00 1.00 O +ATOM 1330 C2' C A 42 -7.501 -39.806 9.521 1.00 1.00 C +ATOM 1331 O2' C A 42 -7.738 -40.854 8.574 1.00 1.00 O +ATOM 1332 C1' C A 42 -7.598 -38.433 8.862 1.00 1.00 C +ATOM 1333 N1 C A 42 -6.470 -37.543 9.197 1.00 1.00 N +ATOM 1334 C2 C A 42 -5.367 -37.567 8.359 1.00 1.00 C +ATOM 1335 O2 C A 42 -5.346 -38.325 7.392 1.00 1.00 O +ATOM 1336 N3 C A 42 -4.323 -36.739 8.639 1.00 1.00 N +ATOM 1337 C4 C A 42 -4.360 -35.919 9.699 1.00 1.00 C +ATOM 1338 N4 C A 42 -3.322 -35.120 9.943 1.00 1.00 N +ATOM 1339 C5 C A 42 -5.496 -35.893 10.569 1.00 1.00 C +ATOM 1340 C6 C A 42 -6.524 -36.716 10.282 1.00 1.00 C +ATOM 1341 H5' C A 42 -11.158 -37.419 10.618 1.00 1.00 H +ATOM 1342 H5'' C A 42 -10.912 -38.785 11.723 1.00 1.00 H +ATOM 1343 H4' C A 42 -10.246 -39.253 9.352 1.00 1.00 H +ATOM 1344 H3' C A 42 -8.171 -39.440 11.545 1.00 1.00 H +ATOM 1345 H2' C A 42 -6.525 -39.923 9.987 1.00 1.00 H +ATOM 1346 HO2' C A 42 -8.434 -40.556 7.985 1.00 1.00 H +ATOM 1347 H1' C A 42 -7.647 -38.558 7.780 1.00 1.00 H +ATOM 1348 H41 C A 42 -2.518 -35.137 9.332 1.00 1.00 H +ATOM 1349 H42 C A 42 -3.339 -34.500 10.739 1.00 1.00 H +ATOM 1350 H5 C A 42 -5.529 -35.228 11.432 1.00 1.00 H +ATOM 1351 H6 C A 42 -7.405 -36.725 10.924 1.00 1.00 H +ATOM 1352 P U A 43 -8.524 -42.198 11.619 1.00 1.00 P +ATOM 1353 OP1 U A 43 -9.318 -43.438 11.469 1.00 1.00 O +ATOM 1354 OP2 U A 43 -8.294 -41.628 12.965 1.00 1.00 O +ATOM 1355 O5' U A 43 -7.090 -42.434 10.918 1.00 1.00 O +ATOM 1356 C5' U A 43 -7.005 -43.062 9.635 1.00 1.00 C +ATOM 1357 C4' U A 43 -5.568 -43.113 9.111 1.00 1.00 C +ATOM 1358 O4' U A 43 -5.014 -41.803 9.060 1.00 1.00 O +ATOM 1359 C3' U A 43 -4.614 -43.947 9.960 1.00 1.00 C +ATOM 1360 O3' U A 43 -4.511 -45.285 9.457 1.00 1.00 O +ATOM 1361 C2' U A 43 -3.274 -43.211 9.853 1.00 1.00 C +ATOM 1362 O2' U A 43 -2.300 -44.000 9.162 1.00 1.00 O +ATOM 1363 C1' U A 43 -3.594 -41.937 9.084 1.00 1.00 C +ATOM 1364 N1 U A 43 -3.020 -40.719 9.698 1.00 1.00 N +ATOM 1365 C2 U A 43 -1.804 -40.275 9.213 1.00 1.00 C +ATOM 1366 O2 U A 43 -1.208 -40.857 8.310 1.00 1.00 O +ATOM 1367 N3 U A 43 -1.294 -39.135 9.807 1.00 1.00 N +ATOM 1368 C4 U A 43 -1.886 -38.411 10.828 1.00 1.00 C +ATOM 1369 O4 U A 43 -1.342 -37.404 11.280 1.00 1.00 O +ATOM 1370 C5 U A 43 -3.153 -38.948 11.272 1.00 1.00 C +ATOM 1371 C6 U A 43 -3.673 -40.063 10.705 1.00 1.00 C +ATOM 1372 H5' U A 43 -7.622 -42.507 8.927 1.00 1.00 H +ATOM 1373 H5'' U A 43 -7.388 -44.079 9.715 1.00 1.00 H +ATOM 1374 H4' U A 43 -5.580 -43.519 8.101 1.00 1.00 H +ATOM 1375 H3' U A 43 -4.952 -43.954 10.999 1.00 1.00 H +ATOM 1376 HO3' U A 43 -4.452 -45.227 8.500 1.00 1.00 H +ATOM 1377 H2' U A 43 -2.913 -42.947 10.849 1.00 1.00 H +ATOM 1378 HO2' U A 43 -1.646 -44.276 9.807 1.00 1.00 H +ATOM 1379 H1' U A 43 -3.229 -42.034 8.060 1.00 1.00 H +ATOM 1380 H3 U A 43 -0.406 -38.798 9.463 1.00 1.00 H +ATOM 1381 H5 U A 43 -3.698 -38.449 12.073 1.00 1.00 H +ATOM 1382 H6 U A 43 -4.630 -40.446 11.058 1.00 1.00 H +TER 1383 U A 43 +ATOM 1384 O5' G B 44 -6.431 33.528 16.025 1.00 1.00 O +ATOM 1385 C5' G B 44 -7.607 33.877 15.289 1.00 1.00 C +ATOM 1386 C4' G B 44 -7.288 34.861 14.166 1.00 1.00 C +ATOM 1387 O4' G B 44 -6.947 36.135 14.725 1.00 1.00 O +ATOM 1388 C3' G B 44 -6.128 34.426 13.274 1.00 1.00 C +ATOM 1389 O3' G B 44 -6.638 33.866 12.058 1.00 1.00 O +ATOM 1390 C2' G B 44 -5.399 35.725 12.975 1.00 1.00 C +ATOM 1391 O2' G B 44 -5.915 36.357 11.798 1.00 1.00 O +ATOM 1392 C1' G B 44 -5.677 36.553 14.216 1.00 1.00 C +ATOM 1393 N9 G B 44 -4.690 36.367 15.292 1.00 1.00 N +ATOM 1394 C8 G B 44 -4.849 35.737 16.498 1.00 1.00 C +ATOM 1395 N7 G B 44 -3.781 35.744 17.243 1.00 1.00 N +ATOM 1396 C5 G B 44 -2.843 36.430 16.478 1.00 1.00 C +ATOM 1397 C6 G B 44 -1.488 36.750 16.771 1.00 1.00 C +ATOM 1398 O6 G B 44 -0.842 36.482 17.781 1.00 1.00 O +ATOM 1399 N1 G B 44 -0.894 37.450 15.729 1.00 1.00 N +ATOM 1400 C2 G B 44 -1.520 37.800 14.552 1.00 1.00 C +ATOM 1401 N2 G B 44 -0.782 38.474 13.669 1.00 1.00 N +ATOM 1402 N3 G B 44 -2.794 37.500 14.274 1.00 1.00 N +ATOM 1403 C4 G B 44 -3.390 36.816 15.280 1.00 1.00 C +ATOM 1404 H5' G B 44 -8.333 34.323 15.974 1.00 1.00 H +ATOM 1405 H5'' G B 44 -8.038 32.977 14.857 1.00 1.00 H +ATOM 1406 H4' G B 44 -8.176 34.985 13.549 1.00 1.00 H +ATOM 1407 H3' G B 44 -5.477 33.722 13.795 1.00 1.00 H +ATOM 1408 H2' G B 44 -4.329 35.542 12.879 1.00 1.00 H +ATOM 1409 HO2' G B 44 -5.469 37.202 11.709 1.00 1.00 H +ATOM 1410 H1' G B 44 -5.722 37.607 13.946 1.00 1.00 H +ATOM 1411 H8 G B 44 -5.787 35.274 16.808 1.00 1.00 H +ATOM 1412 H1 G B 44 0.072 37.711 15.865 1.00 1.00 H +ATOM 1413 H21 G B 44 0.180 38.698 13.882 1.00 1.00 H +ATOM 1414 H22 G B 44 -1.184 38.758 12.788 1.00 1.00 H +ATOM 1415 HO5' G B 44 -6.237 32.608 15.835 1.00 1.00 H +ATOM 1416 P G B 45 -5.821 32.719 11.275 1.00 1.00 P +ATOM 1417 OP1 G B 45 -6.581 32.362 10.055 1.00 1.00 O +ATOM 1418 OP2 G B 45 -5.452 31.666 12.247 1.00 1.00 O +ATOM 1419 O5' G B 45 -4.477 33.481 10.826 1.00 1.00 O +ATOM 1420 C5' G B 45 -4.543 34.684 10.061 1.00 1.00 C +ATOM 1421 C4' G B 45 -3.236 35.470 10.140 1.00 1.00 C +ATOM 1422 O4' G B 45 -2.911 35.756 11.499 1.00 1.00 O +ATOM 1423 C3' G B 45 -2.031 34.745 9.563 1.00 1.00 C +ATOM 1424 O3' G B 45 -1.919 35.037 8.164 1.00 1.00 O +ATOM 1425 C2' G B 45 -0.861 35.360 10.313 1.00 1.00 C +ATOM 1426 O2' G B 45 -0.246 36.406 9.554 1.00 1.00 O +ATOM 1427 C1' G B 45 -1.488 35.895 11.601 1.00 1.00 C +ATOM 1428 N9 G B 45 -1.025 35.203 12.818 1.00 1.00 N +ATOM 1429 C8 G B 45 -1.709 34.364 13.660 1.00 1.00 C +ATOM 1430 N7 G B 45 -1.006 33.944 14.674 1.00 1.00 N +ATOM 1431 C5 G B 45 0.236 34.548 14.493 1.00 1.00 C +ATOM 1432 C6 G B 45 1.415 34.462 15.285 1.00 1.00 C +ATOM 1433 O6 G B 45 1.595 33.824 16.321 1.00 1.00 O +ATOM 1434 N1 G B 45 2.443 35.226 14.750 1.00 1.00 N +ATOM 1435 C2 G B 45 2.353 35.978 13.598 1.00 1.00 C +ATOM 1436 N2 G B 45 3.450 36.646 13.241 1.00 1.00 N +ATOM 1437 N3 G B 45 1.248 36.060 12.853 1.00 1.00 N +ATOM 1438 C4 G B 45 0.233 35.321 13.360 1.00 1.00 C +ATOM 1439 H5' G B 45 -5.355 35.305 10.438 1.00 1.00 H +ATOM 1440 H5'' G B 45 -4.742 34.434 9.020 1.00 1.00 H +ATOM 1441 H4' G B 45 -3.364 36.414 9.614 1.00 1.00 H +ATOM 1442 H3' G B 45 -2.095 33.671 9.746 1.00 1.00 H +ATOM 1443 H2' G B 45 -0.134 34.585 10.560 1.00 1.00 H +ATOM 1444 HO2' G B 45 -0.070 37.131 10.159 1.00 1.00 H +ATOM 1445 H1' G B 45 -1.244 36.953 11.691 1.00 1.00 H +ATOM 1446 H8 G B 45 -2.747 34.072 13.495 1.00 1.00 H +ATOM 1447 H1 G B 45 3.316 35.215 15.258 1.00 1.00 H +ATOM 1448 H21 G B 45 4.281 36.585 13.800 1.00 1.00 H +ATOM 1449 H22 G B 45 3.443 37.214 12.406 1.00 1.00 H +ATOM 1450 P G B 46 -1.097 34.068 7.172 1.00 1.00 P +ATOM 1451 OP1 G B 46 -1.574 34.309 5.792 1.00 1.00 O +ATOM 1452 OP2 G B 46 -1.125 32.699 7.733 1.00 1.00 O +ATOM 1453 O5' G B 46 0.412 34.630 7.290 1.00 1.00 O +ATOM 1454 C5' G B 46 0.730 35.960 6.865 1.00 1.00 C +ATOM 1455 C4' G B 46 2.175 36.330 7.195 1.00 1.00 C +ATOM 1456 O4' G B 46 2.354 36.342 8.615 1.00 1.00 O +ATOM 1457 C3' G B 46 3.213 35.373 6.619 1.00 1.00 C +ATOM 1458 O3' G B 46 3.706 35.893 5.379 1.00 1.00 O +ATOM 1459 C2' G B 46 4.323 35.379 7.660 1.00 1.00 C +ATOM 1460 O2' G B 46 5.308 36.377 7.369 1.00 1.00 O +ATOM 1461 C1' G B 46 3.585 35.688 8.955 1.00 1.00 C +ATOM 1462 N9 G B 46 3.248 34.491 9.746 1.00 1.00 N +ATOM 1463 C8 G B 46 2.120 33.713 9.682 1.00 1.00 C +ATOM 1464 N7 G B 46 2.113 32.721 10.529 1.00 1.00 N +ATOM 1465 C5 G B 46 3.324 32.850 11.204 1.00 1.00 C +ATOM 1466 C6 G B 46 3.875 32.053 12.246 1.00 1.00 C +ATOM 1467 O6 G B 46 3.390 31.060 12.786 1.00 1.00 O +ATOM 1468 N1 G B 46 5.117 32.526 12.645 1.00 1.00 N +ATOM 1469 C2 G B 46 5.753 33.627 12.111 1.00 1.00 C +ATOM 1470 N2 G B 46 6.945 33.926 12.626 1.00 1.00 N +ATOM 1471 N3 G B 46 5.237 34.377 11.134 1.00 1.00 N +ATOM 1472 C4 G B 46 4.025 33.931 10.731 1.00 1.00 C +ATOM 1473 H5' G B 46 0.062 36.661 7.363 1.00 1.00 H +ATOM 1474 H5'' G B 46 0.582 36.034 5.788 1.00 1.00 H +ATOM 1475 H4' G B 46 2.375 37.331 6.818 1.00 1.00 H +ATOM 1476 H3' G B 46 2.796 34.371 6.498 1.00 1.00 H +ATOM 1477 H2' G B 46 4.781 34.393 7.725 1.00 1.00 H +ATOM 1478 HO2' G B 46 4.841 37.195 7.188 1.00 1.00 H +ATOM 1479 H1' G B 46 4.191 36.357 9.564 1.00 1.00 H +ATOM 1480 H8 G B 46 1.304 33.905 8.986 1.00 1.00 H +ATOM 1481 H1 G B 46 5.573 32.010 13.385 1.00 1.00 H +ATOM 1482 H21 G B 46 7.332 33.360 13.364 1.00 1.00 H +ATOM 1483 H22 G B 46 7.461 34.722 12.276 1.00 1.00 H +ATOM 1484 P A B 47 3.939 34.924 4.113 1.00 1.00 P +ATOM 1485 OP1 A B 47 4.310 35.763 2.952 1.00 1.00 O +ATOM 1486 OP2 A B 47 2.786 34.002 4.017 1.00 1.00 O +ATOM 1487 O5' A B 47 5.231 34.068 4.547 1.00 1.00 O +ATOM 1488 C5' A B 47 6.547 34.607 4.394 1.00 1.00 C +ATOM 1489 C4' A B 47 7.607 33.637 4.905 1.00 1.00 C +ATOM 1490 O4' A B 47 7.483 33.493 6.313 1.00 1.00 O +ATOM 1491 C3' A B 47 7.510 32.241 4.313 1.00 1.00 C +ATOM 1492 O3' A B 47 8.330 32.155 3.144 1.00 1.00 O +ATOM 1493 C2' A B 47 8.071 31.353 5.414 1.00 1.00 C +ATOM 1494 O2' A B 47 9.473 31.122 5.233 1.00 1.00 O +ATOM 1495 C1' A B 47 7.798 32.147 6.691 1.00 1.00 C +ATOM 1496 N9 A B 47 6.659 31.641 7.478 1.00 1.00 N +ATOM 1497 C8 A B 47 5.320 31.882 7.307 1.00 1.00 C +ATOM 1498 N7 A B 47 4.560 31.287 8.186 1.00 1.00 N +ATOM 1499 C5 A B 47 5.461 30.602 8.995 1.00 1.00 C +ATOM 1500 C6 A B 47 5.288 29.773 10.116 1.00 1.00 C +ATOM 1501 N6 A B 47 4.093 29.486 10.633 1.00 1.00 N +ATOM 1502 N1 A B 47 6.394 29.258 10.677 1.00 1.00 N +ATOM 1503 C2 A B 47 7.581 29.549 10.158 1.00 1.00 C +ATOM 1504 N3 A B 47 7.872 30.310 9.113 1.00 1.00 N +ATOM 1505 C4 A B 47 6.743 30.812 8.571 1.00 1.00 C +ATOM 1506 H5' A B 47 6.619 35.539 4.957 1.00 1.00 H +ATOM 1507 H5'' A B 47 6.730 34.813 3.340 1.00 1.00 H +ATOM 1508 H4' A B 47 8.593 34.044 4.687 1.00 1.00 H +ATOM 1509 H3' A B 47 6.472 31.984 4.095 1.00 1.00 H +ATOM 1510 H2' A B 47 7.526 30.407 5.442 1.00 1.00 H +ATOM 1511 HO2' A B 47 9.795 30.683 6.024 1.00 1.00 H +ATOM 1512 H1' A B 47 8.691 32.145 7.315 1.00 1.00 H +ATOM 1513 H8 A B 47 4.925 32.513 6.511 1.00 1.00 H +ATOM 1514 H61 A B 47 4.024 28.884 11.440 1.00 1.00 H +ATOM 1515 H62 A B 47 3.257 29.871 10.215 1.00 1.00 H +ATOM 1516 H2 A B 47 8.435 29.097 10.662 1.00 1.00 H +ATOM 1517 P U B 48 7.960 31.132 1.957 1.00 1.00 P +ATOM 1518 OP1 U B 48 9.039 31.188 0.946 1.00 1.00 O +ATOM 1519 OP2 U B 48 6.558 31.378 1.553 1.00 1.00 O +ATOM 1520 O5' U B 48 8.031 29.699 2.687 1.00 1.00 O +ATOM 1521 C5' U B 48 9.269 29.200 3.198 1.00 1.00 C +ATOM 1522 C4' U B 48 9.058 27.933 4.021 1.00 1.00 C +ATOM 1523 O4' U B 48 8.314 28.242 5.190 1.00 1.00 O +ATOM 1524 C3' U B 48 8.289 26.842 3.299 1.00 1.00 C +ATOM 1525 O3' U B 48 9.210 25.968 2.643 1.00 1.00 O +ATOM 1526 C2' U B 48 7.571 26.096 4.419 1.00 1.00 C +ATOM 1527 O2' U B 48 8.298 24.928 4.816 1.00 1.00 O +ATOM 1528 C1' U B 48 7.499 27.120 5.559 1.00 1.00 C +ATOM 1529 N1 U B 48 6.137 27.638 5.816 1.00 1.00 N +ATOM 1530 C2 U B 48 5.425 27.093 6.866 1.00 1.00 C +ATOM 1531 O2 U B 48 5.886 26.199 7.573 1.00 1.00 O +ATOM 1532 N3 U B 48 4.162 27.614 7.080 1.00 1.00 N +ATOM 1533 C4 U B 48 3.557 28.618 6.342 1.00 1.00 C +ATOM 1534 O4 U B 48 2.425 29.004 6.623 1.00 1.00 O +ATOM 1535 C5 U B 48 4.372 29.129 5.264 1.00 1.00 C +ATOM 1536 C6 U B 48 5.614 28.634 5.036 1.00 1.00 C +ATOM 1537 H5' U B 48 9.727 29.962 3.830 1.00 1.00 H +ATOM 1538 H5'' U B 48 9.936 28.977 2.366 1.00 1.00 H +ATOM 1539 H4' U B 48 10.028 27.540 4.324 1.00 1.00 H +ATOM 1540 H3' U B 48 7.575 27.271 2.594 1.00 1.00 H +ATOM 1541 H2' U B 48 6.562 25.831 4.096 1.00 1.00 H +ATOM 1542 HO2' U B 48 8.849 25.172 5.564 1.00 1.00 H +ATOM 1543 H1' U B 48 7.896 26.671 6.470 1.00 1.00 H +ATOM 1544 H3 U B 48 3.631 27.224 7.845 1.00 1.00 H +ATOM 1545 H5 U B 48 3.984 29.922 4.626 1.00 1.00 H +ATOM 1546 H6 U B 48 6.207 29.038 4.215 1.00 1.00 H +ATOM 1547 P A B 49 8.682 24.817 1.651 1.00 1.00 P +ATOM 1548 OP1 A B 49 9.717 24.582 0.619 1.00 1.00 O +ATOM 1549 OP2 A B 49 7.297 25.150 1.247 1.00 1.00 O +ATOM 1550 O5' A B 49 8.630 23.533 2.615 1.00 1.00 O +ATOM 1551 C5' A B 49 9.718 23.255 3.502 1.00 1.00 C +ATOM 1552 C4' A B 49 9.638 21.839 4.061 1.00 1.00 C +ATOM 1553 O4' A B 49 8.299 21.571 4.493 1.00 1.00 O +ATOM 1554 C3' A B 49 10.026 20.756 3.049 1.00 1.00 C +ATOM 1555 O3' A B 49 11.001 19.872 3.629 1.00 1.00 O +ATOM 1556 C2' A B 49 8.733 19.997 2.785 1.00 1.00 C +ATOM 1557 O2' A B 49 8.986 18.603 2.610 1.00 1.00 O +ATOM 1558 C1' A B 49 7.917 20.275 4.035 1.00 1.00 C +ATOM 1559 N9 A B 49 6.454 20.273 3.834 1.00 1.00 N +ATOM 1560 C8 A B 49 5.711 20.954 2.905 1.00 1.00 C +ATOM 1561 N7 A B 49 4.427 20.741 2.998 1.00 1.00 N +ATOM 1562 C5 A B 49 4.314 19.855 4.065 1.00 1.00 C +ATOM 1563 C6 A B 49 3.209 19.238 4.674 1.00 1.00 C +ATOM 1564 N6 A B 49 1.951 19.432 4.275 1.00 1.00 N +ATOM 1565 N1 A B 49 3.454 18.416 5.708 1.00 1.00 N +ATOM 1566 C2 A B 49 4.709 18.226 6.101 1.00 1.00 C +ATOM 1567 N3 A B 49 5.824 18.745 5.614 1.00 1.00 N +ATOM 1568 C4 A B 49 5.544 19.565 4.578 1.00 1.00 C +ATOM 1569 H5' A B 49 9.695 23.967 4.327 1.00 1.00 H +ATOM 1570 H5'' A B 49 10.655 23.371 2.957 1.00 1.00 H +ATOM 1571 H4' A B 49 10.298 21.764 4.923 1.00 1.00 H +ATOM 1572 H3' A B 49 10.402 21.203 2.127 1.00 1.00 H +ATOM 1573 H2' A B 49 8.228 20.413 1.909 1.00 1.00 H +ATOM 1574 HO2' A B 49 9.933 18.497 2.483 1.00 1.00 H +ATOM 1575 H1' A B 49 8.169 19.542 4.794 1.00 1.00 H +ATOM 1576 H8 A B 49 6.152 21.612 2.156 1.00 1.00 H +ATOM 1577 H61 A B 49 1.194 18.962 4.751 1.00 1.00 H +ATOM 1578 H62 A B 49 1.750 20.045 3.504 1.00 1.00 H +ATOM 1579 H2 A B 49 4.837 17.546 6.944 1.00 1.00 H +ATOM 1580 P U B 50 10.727 19.105 5.024 1.00 1.00 P +ATOM 1581 OP1 U B 50 9.986 20.015 5.925 1.00 1.00 O +ATOM 1582 OP2 U B 50 12.002 18.500 5.473 1.00 1.00 O +ATOM 1583 O5' U B 50 9.738 17.913 4.577 1.00 1.00 O +ATOM 1584 C5' U B 50 9.009 17.141 5.537 1.00 1.00 C +ATOM 1585 C4' U B 50 8.082 16.138 4.849 1.00 1.00 C +ATOM 1586 O4' U B 50 7.479 16.744 3.696 1.00 1.00 O +ATOM 1587 C3' U B 50 8.801 14.862 4.376 1.00 1.00 C +ATOM 1588 O3' U B 50 8.079 13.687 4.785 1.00 1.00 O +ATOM 1589 C2' U B 50 8.766 14.955 2.857 1.00 1.00 C +ATOM 1590 O2' U B 50 8.611 13.664 2.258 1.00 1.00 O +ATOM 1591 C1' U B 50 7.557 15.835 2.595 1.00 1.00 C +ATOM 1592 N1 U B 50 7.618 16.646 1.357 1.00 1.00 N +ATOM 1593 C2 U B 50 8.331 16.149 0.284 1.00 1.00 C +ATOM 1594 O2 U B 50 8.873 15.047 0.315 1.00 1.00 O +ATOM 1595 N3 U B 50 8.403 16.967 -0.828 1.00 1.00 N +ATOM 1596 C4 U B 50 7.832 18.221 -0.959 1.00 1.00 C +ATOM 1597 O4 U B 50 7.959 18.863 -1.999 1.00 1.00 O +ATOM 1598 C5 U B 50 7.105 18.661 0.211 1.00 1.00 C +ATOM 1599 C6 U B 50 7.021 17.877 1.313 1.00 1.00 C +ATOM 1600 H5' U B 50 8.414 17.806 6.161 1.00 1.00 H +ATOM 1601 H5'' U B 50 9.714 16.600 6.169 1.00 1.00 H +ATOM 1602 H4' U B 50 7.291 15.876 5.542 1.00 1.00 H +ATOM 1603 H3' U B 50 9.831 14.838 4.735 1.00 1.00 H +ATOM 1604 H2' U B 50 9.667 15.450 2.489 1.00 1.00 H +ATOM 1605 HO2' U B 50 8.216 13.088 2.918 1.00 1.00 H +ATOM 1606 H1' U B 50 6.663 15.215 2.573 1.00 1.00 H +ATOM 1607 H3 U B 50 8.922 16.617 -1.621 1.00 1.00 H +ATOM 1608 H5 U B 50 6.619 19.636 0.206 1.00 1.00 H +ATOM 1609 H6 U B 50 6.468 18.235 2.181 1.00 1.00 H +ATOM 1610 P G B 51 7.548 13.513 6.295 1.00 1.00 P +ATOM 1611 OP1 G B 51 8.535 14.138 7.206 1.00 1.00 O +ATOM 1612 OP2 G B 51 7.145 12.103 6.491 1.00 1.00 O +ATOM 1613 O5' G B 51 6.221 14.431 6.279 1.00 1.00 O +ATOM 1614 C5' G B 51 5.146 14.193 7.192 1.00 1.00 C +ATOM 1615 C4' G B 51 3.866 13.785 6.464 1.00 1.00 C +ATOM 1616 O4' G B 51 3.255 14.930 5.862 1.00 1.00 O +ATOM 1617 C3' G B 51 4.091 12.764 5.361 1.00 1.00 C +ATOM 1618 O3' G B 51 3.833 11.451 5.866 1.00 1.00 O +ATOM 1619 C2' G B 51 3.056 13.119 4.303 1.00 1.00 C +ATOM 1620 O2' G B 51 1.867 12.336 4.458 1.00 1.00 O +ATOM 1621 C1' G B 51 2.780 14.599 4.545 1.00 1.00 C +ATOM 1622 N9 G B 51 3.465 15.498 3.594 1.00 1.00 N +ATOM 1623 C8 G B 51 4.633 16.188 3.783 1.00 1.00 C +ATOM 1624 N7 G B 51 4.999 16.900 2.755 1.00 1.00 N +ATOM 1625 C5 G B 51 4.001 16.668 1.814 1.00 1.00 C +ATOM 1626 C6 G B 51 3.859 17.176 0.493 1.00 1.00 C +ATOM 1627 O6 G B 51 4.602 17.945 -0.112 1.00 1.00 O +ATOM 1628 N1 G B 51 2.711 16.692 -0.117 1.00 1.00 N +ATOM 1629 C2 G B 51 1.809 15.827 0.465 1.00 1.00 C +ATOM 1630 N2 G B 51 0.764 15.475 -0.283 1.00 1.00 N +ATOM 1631 N3 G B 51 1.940 15.348 1.706 1.00 1.00 N +ATOM 1632 C4 G B 51 3.056 15.809 2.318 1.00 1.00 C +ATOM 1633 H5' G B 51 4.957 15.107 7.757 1.00 1.00 H +ATOM 1634 H5'' G B 51 5.433 13.401 7.884 1.00 1.00 H +ATOM 1635 H4' G B 51 3.172 13.366 7.190 1.00 1.00 H +ATOM 1636 H3' G B 51 5.102 12.842 4.958 1.00 1.00 H +ATOM 1637 H2' G B 51 3.481 12.980 3.307 1.00 1.00 H +ATOM 1638 HO2' G B 51 2.023 11.719 5.177 1.00 1.00 H +ATOM 1639 H1' G B 51 1.708 14.778 4.494 1.00 1.00 H +ATOM 1640 H8 G B 51 5.205 16.148 4.711 1.00 1.00 H +ATOM 1641 H1 G B 51 2.542 17.011 -1.061 1.00 1.00 H +ATOM 1642 H21 G B 51 0.671 15.844 -1.224 1.00 1.00 H +ATOM 1643 H22 G B 51 0.069 14.846 0.080 1.00 1.00 H +ATOM 1644 P G B 52 4.251 10.159 5.009 1.00 1.00 P +ATOM 1645 OP1 G B 52 3.910 8.950 5.791 1.00 1.00 O +ATOM 1646 OP2 G B 52 5.632 10.355 4.514 1.00 1.00 O +ATOM 1647 O5' G B 52 3.249 10.246 3.754 1.00 1.00 O +ATOM 1648 C5' G B 52 3.761 10.281 2.423 1.00 1.00 C +ATOM 1649 C4' G B 52 2.640 10.372 1.393 1.00 1.00 C +ATOM 1650 O4' G B 52 2.270 11.742 1.187 1.00 1.00 O +ATOM 1651 C3' G B 52 3.018 9.799 0.037 1.00 1.00 C +ATOM 1652 O3' G B 52 2.594 8.432 -0.044 1.00 1.00 O +ATOM 1653 C2' G B 52 2.224 10.646 -0.941 1.00 1.00 C +ATOM 1654 O2' G B 52 0.949 10.062 -1.226 1.00 1.00 O +ATOM 1655 C1' G B 52 2.081 11.976 -0.216 1.00 1.00 C +ATOM 1656 N9 G B 52 3.064 12.991 -0.643 1.00 1.00 N +ATOM 1657 C8 G B 52 4.021 13.630 0.102 1.00 1.00 C +ATOM 1658 N7 G B 52 4.729 14.492 -0.574 1.00 1.00 N +ATOM 1659 C5 G B 52 4.202 14.421 -1.861 1.00 1.00 C +ATOM 1660 C6 G B 52 4.569 15.133 -3.036 1.00 1.00 C +ATOM 1661 O6 G B 52 5.449 15.980 -3.172 1.00 1.00 O +ATOM 1662 N1 G B 52 3.786 14.762 -4.121 1.00 1.00 N +ATOM 1663 C2 G B 52 2.775 13.826 -4.084 1.00 1.00 C +ATOM 1664 N2 G B 52 2.132 13.606 -5.230 1.00 1.00 N +ATOM 1665 N3 G B 52 2.428 13.156 -2.980 1.00 1.00 N +ATOM 1666 C4 G B 52 3.182 13.505 -1.912 1.00 1.00 C +ATOM 1667 H5' G B 52 4.339 9.376 2.240 1.00 1.00 H +ATOM 1668 H5'' G B 52 4.416 11.148 2.315 1.00 1.00 H +ATOM 1669 H4' G B 52 1.773 9.834 1.773 1.00 1.00 H +ATOM 1670 H3' G B 52 4.090 9.896 -0.142 1.00 1.00 H +ATOM 1671 H2' G B 52 2.795 10.790 -1.856 1.00 1.00 H +ATOM 1672 HO2' G B 52 0.349 10.336 -0.529 1.00 1.00 H +ATOM 1673 H1' G B 52 1.077 12.365 -0.381 1.00 1.00 H +ATOM 1674 H8 G B 52 4.177 13.436 1.164 1.00 1.00 H +ATOM 1675 H1 G B 52 3.988 15.227 -4.995 1.00 1.00 H +ATOM 1676 H21 G B 52 2.396 14.113 -6.063 1.00 1.00 H +ATOM 1677 H22 G B 52 1.382 12.930 -5.267 1.00 1.00 H +ATOM 1678 P A B 53 3.480 7.346 -0.837 1.00 1.00 P +ATOM 1679 OP1 A B 53 2.858 6.016 -0.649 1.00 1.00 O +ATOM 1680 OP2 A B 53 4.899 7.554 -0.475 1.00 1.00 O +ATOM 1681 O5' A B 53 3.284 7.778 -2.375 1.00 1.00 O +ATOM 1682 C5' A B 53 2.010 7.646 -3.010 1.00 1.00 C +ATOM 1683 C4' A B 53 2.048 8.142 -4.452 1.00 1.00 C +ATOM 1684 O4' A B 53 2.227 9.552 -4.482 1.00 1.00 O +ATOM 1685 C3' A B 53 3.171 7.556 -5.289 1.00 1.00 C +ATOM 1686 O3' A B 53 2.739 6.329 -5.889 1.00 1.00 O +ATOM 1687 C2' A B 53 3.409 8.616 -6.352 1.00 1.00 C +ATOM 1688 O2' A B 53 2.681 8.325 -7.551 1.00 1.00 O +ATOM 1689 C1' A B 53 2.909 9.905 -5.694 1.00 1.00 C +ATOM 1690 N9 A B 53 3.983 10.845 -5.334 1.00 1.00 N +ATOM 1691 C8 A B 53 4.675 10.954 -4.154 1.00 1.00 C +ATOM 1692 N7 A B 53 5.575 11.898 -4.156 1.00 1.00 N +ATOM 1693 C5 A B 53 5.471 12.455 -5.427 1.00 1.00 C +ATOM 1694 C6 A B 53 6.156 13.504 -6.063 1.00 1.00 C +ATOM 1695 N6 A B 53 7.122 14.210 -5.474 1.00 1.00 N +ATOM 1696 N1 A B 53 5.803 13.794 -7.327 1.00 1.00 N +ATOM 1697 C2 A B 53 4.841 13.088 -7.909 1.00 1.00 C +ATOM 1698 N3 A B 53 4.128 12.085 -7.420 1.00 1.00 N +ATOM 1699 C4 A B 53 4.504 11.819 -6.152 1.00 1.00 C +ATOM 1700 H5' A B 53 1.273 8.226 -2.453 1.00 1.00 H +ATOM 1701 H5'' A B 53 1.717 6.597 -3.004 1.00 1.00 H +ATOM 1702 H4' A B 53 1.099 7.909 -4.927 1.00 1.00 H +ATOM 1703 H3' A B 53 4.067 7.407 -4.683 1.00 1.00 H +ATOM 1704 H2' A B 53 4.478 8.696 -6.561 1.00 1.00 H +ATOM 1705 HO2' A B 53 1.812 8.010 -7.288 1.00 1.00 H +ATOM 1706 H1' A B 53 2.212 10.403 -6.366 1.00 1.00 H +ATOM 1707 H8 A B 53 4.490 10.309 -3.295 1.00 1.00 H +ATOM 1708 H61 A B 53 7.581 14.954 -5.976 1.00 1.00 H +ATOM 1709 H62 A B 53 7.393 13.999 -4.524 1.00 1.00 H +ATOM 1710 H2 A B 53 4.605 13.375 -8.934 1.00 1.00 H +ATOM 1711 P A B 54 3.817 5.244 -6.394 1.00 1.00 P +ATOM 1712 OP1 A B 54 3.092 4.010 -6.772 1.00 1.00 O +ATOM 1713 OP2 A B 54 4.910 5.182 -5.399 1.00 1.00 O +ATOM 1714 O5' A B 54 4.397 5.921 -7.736 1.00 1.00 O +ATOM 1715 C5' A B 54 3.560 6.092 -8.884 1.00 1.00 C +ATOM 1716 C4' A B 54 4.303 6.788 -10.021 1.00 1.00 C +ATOM 1717 O4' A B 54 4.583 8.140 -9.668 1.00 1.00 O +ATOM 1718 C3' A B 54 5.638 6.158 -10.373 1.00 1.00 C +ATOM 1719 O3' A B 54 5.454 5.113 -11.340 1.00 1.00 O +ATOM 1720 C2' A B 54 6.404 7.315 -10.987 1.00 1.00 C +ATOM 1721 O2' A B 54 6.213 7.378 -12.404 1.00 1.00 O +ATOM 1722 C1' A B 54 5.817 8.539 -10.285 1.00 1.00 C +ATOM 1723 N9 A B 54 6.690 9.078 -9.229 1.00 1.00 N +ATOM 1724 C8 A B 54 6.856 8.633 -7.943 1.00 1.00 C +ATOM 1725 N7 A B 54 7.724 9.322 -7.254 1.00 1.00 N +ATOM 1726 C5 A B 54 8.161 10.293 -8.148 1.00 1.00 C +ATOM 1727 C6 A B 54 9.089 11.341 -8.031 1.00 1.00 C +ATOM 1728 N6 A B 54 9.775 11.587 -6.914 1.00 1.00 N +ATOM 1729 N1 A B 54 9.283 12.117 -9.110 1.00 1.00 N +ATOM 1730 C2 A B 54 8.601 11.863 -10.221 1.00 1.00 C +ATOM 1731 N3 A B 54 7.708 10.913 -10.455 1.00 1.00 N +ATOM 1732 C4 A B 54 7.535 10.153 -9.354 1.00 1.00 C +ATOM 1733 H5' A B 54 2.692 6.692 -8.607 1.00 1.00 H +ATOM 1734 H5'' A B 54 3.223 5.115 -9.227 1.00 1.00 H +ATOM 1735 H4' A B 54 3.670 6.790 -10.906 1.00 1.00 H +ATOM 1736 H3' A B 54 6.142 5.790 -9.477 1.00 1.00 H +ATOM 1737 H2' A B 54 7.458 7.228 -10.743 1.00 1.00 H +ATOM 1738 HO2' A B 54 6.807 6.736 -12.800 1.00 1.00 H +ATOM 1739 H1' A B 54 5.621 9.321 -11.019 1.00 1.00 H +ATOM 1740 H8 A B 54 6.316 7.779 -7.534 1.00 1.00 H +ATOM 1741 H61 A B 54 10.429 12.353 -6.882 1.00 1.00 H +ATOM 1742 H62 A B 54 9.635 11.010 -6.101 1.00 1.00 H +ATOM 1743 H2 A B 54 8.807 12.529 -11.059 1.00 1.00 H +ATOM 1744 P G B 55 6.457 3.850 -11.384 1.00 1.00 P +ATOM 1745 OP1 G B 55 5.768 2.741 -12.080 1.00 1.00 O +ATOM 1746 OP2 G B 55 6.993 3.642 -10.021 1.00 1.00 O +ATOM 1747 O5' G B 55 7.663 4.365 -12.325 1.00 1.00 O +ATOM 1748 C5' G B 55 7.552 4.317 -13.753 1.00 1.00 C +ATOM 1749 C4' G B 55 8.697 5.066 -14.438 1.00 1.00 C +ATOM 1750 O4' G B 55 8.748 6.406 -13.955 1.00 1.00 O +ATOM 1751 C3' G B 55 10.079 4.465 -14.208 1.00 1.00 C +ATOM 1752 O3' G B 55 10.384 3.541 -15.260 1.00 1.00 O +ATOM 1753 C2' G B 55 10.998 5.674 -14.294 1.00 1.00 C +ATOM 1754 O2' G B 55 11.435 5.911 -15.637 1.00 1.00 O +ATOM 1755 C1' G B 55 10.118 6.802 -13.789 1.00 1.00 C +ATOM 1756 N9 G B 55 10.326 7.094 -12.368 1.00 1.00 N +ATOM 1757 C8 G B 55 9.776 6.481 -11.271 1.00 1.00 C +ATOM 1758 N7 G B 55 10.144 7.002 -10.135 1.00 1.00 N +ATOM 1759 C5 G B 55 11.002 8.035 -10.502 1.00 1.00 C +ATOM 1760 C6 G B 55 11.714 8.960 -9.689 1.00 1.00 C +ATOM 1761 O6 G B 55 11.723 9.049 -8.463 1.00 1.00 O +ATOM 1762 N1 G B 55 12.467 9.838 -10.457 1.00 1.00 N +ATOM 1763 C2 G B 55 12.530 9.829 -11.833 1.00 1.00 C +ATOM 1764 N2 G B 55 13.313 10.750 -12.393 1.00 1.00 N +ATOM 1765 N3 G B 55 11.859 8.962 -12.600 1.00 1.00 N +ATOM 1766 C4 G B 55 11.119 8.098 -11.867 1.00 1.00 C +ATOM 1767 H5' G B 55 6.605 4.769 -14.050 1.00 1.00 H +ATOM 1768 H5'' G B 55 7.564 3.277 -14.075 1.00 1.00 H +ATOM 1769 H4' G B 55 8.502 5.095 -15.508 1.00 1.00 H +ATOM 1770 H3' G B 55 10.142 3.992 -13.226 1.00 1.00 H +ATOM 1771 H2' G B 55 11.852 5.556 -13.620 1.00 1.00 H +ATOM 1772 HO2' G B 55 10.649 5.986 -16.183 1.00 1.00 H +ATOM 1773 H1' G B 55 10.309 7.703 -14.370 1.00 1.00 H +ATOM 1774 H8 G B 55 9.095 5.632 -11.343 1.00 1.00 H +ATOM 1775 H1 G B 55 13.001 10.526 -9.948 1.00 1.00 H +ATOM 1776 H21 G B 55 13.817 11.403 -11.815 1.00 1.00 H +ATOM 1777 H22 G B 55 13.400 10.794 -13.399 1.00 1.00 H +ATOM 1778 P A B 56 11.348 2.276 -14.995 1.00 1.00 P +ATOM 1779 OP1 A B 56 11.454 1.505 -16.253 1.00 1.00 O +ATOM 1780 OP2 A B 56 10.898 1.606 -13.754 1.00 1.00 O +ATOM 1781 O5' A B 56 12.774 2.965 -14.707 1.00 1.00 O +ATOM 1782 C5' A B 56 13.563 3.480 -15.781 1.00 1.00 C +ATOM 1783 C4' A B 56 14.818 4.179 -15.268 1.00 1.00 C +ATOM 1784 O4' A B 56 14.457 5.332 -14.514 1.00 1.00 O +ATOM 1785 C3' A B 56 15.681 3.326 -14.354 1.00 1.00 C +ATOM 1786 O3' A B 56 16.608 2.562 -15.138 1.00 1.00 O +ATOM 1787 C2' A B 56 16.417 4.368 -13.528 1.00 1.00 C +ATOM 1788 O2' A B 56 17.643 4.763 -14.157 1.00 1.00 O +ATOM 1789 C1' A B 56 15.419 5.527 -13.467 1.00 1.00 C +ATOM 1790 N9 A B 56 14.682 5.612 -12.196 1.00 1.00 N +ATOM 1791 C8 A B 56 13.583 4.908 -11.777 1.00 1.00 C +ATOM 1792 N7 A B 56 13.167 5.241 -10.585 1.00 1.00 N +ATOM 1793 C5 A B 56 14.055 6.236 -10.189 1.00 1.00 C +ATOM 1794 C6 A B 56 14.159 7.002 -9.016 1.00 1.00 C +ATOM 1795 N6 A B 56 13.322 6.876 -7.985 1.00 1.00 N +ATOM 1796 N1 A B 56 15.158 7.900 -8.952 1.00 1.00 N +ATOM 1797 C2 A B 56 15.988 8.019 -9.982 1.00 1.00 C +ATOM 1798 N3 A B 56 15.994 7.361 -11.131 1.00 1.00 N +ATOM 1799 C4 A B 56 14.981 6.468 -11.165 1.00 1.00 C +ATOM 1800 H5' A B 56 12.967 4.196 -16.350 1.00 1.00 H +ATOM 1801 H5'' A B 56 13.855 2.660 -16.435 1.00 1.00 H +ATOM 1802 H4' A B 56 15.416 4.499 -16.118 1.00 1.00 H +ATOM 1803 H3' A B 56 15.065 2.685 -13.720 1.00 1.00 H +ATOM 1804 H2' A B 56 16.604 3.985 -12.524 1.00 1.00 H +ATOM 1805 HO2' A B 56 17.471 5.579 -14.630 1.00 1.00 H +ATOM 1806 H1' A B 56 15.944 6.471 -13.629 1.00 1.00 H +ATOM 1807 H8 A B 56 13.100 4.141 -12.382 1.00 1.00 H +ATOM 1808 H61 A B 56 13.448 7.462 -7.158 1.00 1.00 H +ATOM 1809 H62 A B 56 12.569 6.204 -8.021 1.00 1.00 H +ATOM 1810 H2 A B 56 16.774 8.764 -9.864 1.00 1.00 H +ATOM 1811 P A B 57 16.869 1.003 -14.821 1.00 1.00 P +ATOM 1812 OP1 A B 57 17.700 0.444 -15.910 1.00 1.00 O +ATOM 1813 OP2 A B 57 15.569 0.375 -14.491 1.00 1.00 O +ATOM 1814 O5' A B 57 17.760 1.049 -13.481 1.00 1.00 O +ATOM 1815 C5' A B 57 19.172 1.271 -13.558 1.00 1.00 C +ATOM 1816 C4' A B 57 19.758 1.654 -12.202 1.00 1.00 C +ATOM 1817 O4' A B 57 19.080 2.794 -11.688 1.00 1.00 O +ATOM 1818 C3' A B 57 19.645 0.579 -11.133 1.00 1.00 C +ATOM 1819 O3' A B 57 20.798 -0.275 -11.171 1.00 1.00 O +ATOM 1820 C2' A B 57 19.629 1.374 -9.838 1.00 1.00 C +ATOM 1821 O2' A B 57 20.932 1.448 -9.252 1.00 1.00 O +ATOM 1822 C1' A B 57 19.121 2.753 -10.255 1.00 1.00 C +ATOM 1823 N9 A B 57 17.770 3.056 -9.752 1.00 1.00 N +ATOM 1824 C8 A B 57 16.552 2.722 -10.288 1.00 1.00 C +ATOM 1825 N7 A B 57 15.534 3.157 -9.598 1.00 1.00 N +ATOM 1826 C5 A B 57 16.120 3.829 -8.529 1.00 1.00 C +ATOM 1827 C6 A B 57 15.578 4.520 -7.432 1.00 1.00 C +ATOM 1828 N6 A B 57 14.268 4.653 -7.226 1.00 1.00 N +ATOM 1829 N1 A B 57 16.443 5.066 -6.560 1.00 1.00 N +ATOM 1830 C2 A B 57 17.748 4.931 -6.771 1.00 1.00 C +ATOM 1831 N3 A B 57 18.375 4.309 -7.758 1.00 1.00 N +ATOM 1832 C4 A B 57 17.481 3.773 -8.615 1.00 1.00 C +ATOM 1833 H5' A B 57 19.366 2.076 -14.268 1.00 1.00 H +ATOM 1834 H5'' A B 57 19.656 0.361 -13.909 1.00 1.00 H +ATOM 1835 H4' A B 57 20.807 1.911 -12.333 1.00 1.00 H +ATOM 1836 H3' A B 57 18.722 0.010 -11.251 1.00 1.00 H +ATOM 1837 H2' A B 57 18.922 0.923 -9.147 1.00 1.00 H +ATOM 1838 HO2' A B 57 20.831 1.272 -8.313 1.00 1.00 H +ATOM 1839 H1' A B 57 19.810 3.517 -9.895 1.00 1.00 H +ATOM 1840 H8 A B 57 16.445 2.142 -11.204 1.00 1.00 H +ATOM 1841 H61 A B 57 13.934 5.158 -6.425 1.00 1.00 H +ATOM 1842 H62 A B 57 13.610 4.245 -7.876 1.00 1.00 H +ATOM 1843 H2 A B 57 18.392 5.397 -6.025 1.00 1.00 H +ATOM 1844 P C B 58 20.757 -1.744 -10.505 1.00 1.00 P +ATOM 1845 OP1 C B 58 21.978 -2.471 -10.918 1.00 1.00 O +ATOM 1846 OP2 C B 58 19.426 -2.331 -10.769 1.00 1.00 O +ATOM 1847 O5' C B 58 20.865 -1.436 -8.924 1.00 1.00 O +ATOM 1848 C5' C B 58 22.134 -1.155 -8.319 1.00 1.00 C +ATOM 1849 C4' C B 58 21.994 -0.833 -6.830 1.00 1.00 C +ATOM 1850 O4' C B 58 21.199 0.332 -6.662 1.00 1.00 O +ATOM 1851 C3' C B 58 21.323 -1.912 -6.002 1.00 1.00 C +ATOM 1852 O3' C B 58 22.297 -2.854 -5.536 1.00 1.00 O +ATOM 1853 C2' C B 58 20.744 -1.135 -4.828 1.00 1.00 C +ATOM 1854 O2' C B 58 21.660 -1.086 -3.728 1.00 1.00 O +ATOM 1855 C1' C B 58 20.493 0.258 -5.409 1.00 1.00 C +ATOM 1856 N1 C B 58 19.071 0.530 -5.695 1.00 1.00 N +ATOM 1857 C2 C B 58 18.358 1.313 -4.801 1.00 1.00 C +ATOM 1858 O2 C B 58 18.914 1.766 -3.801 1.00 1.00 O +ATOM 1859 N3 C B 58 17.046 1.562 -5.062 1.00 1.00 N +ATOM 1860 C4 C B 58 16.456 1.063 -6.158 1.00 1.00 C +ATOM 1861 N4 C B 58 15.169 1.322 -6.386 1.00 1.00 N +ATOM 1862 C5 C B 58 17.189 0.256 -7.085 1.00 1.00 C +ATOM 1863 C6 C B 58 18.487 0.016 -6.816 1.00 1.00 C +ATOM 1864 H5' C B 58 22.585 -0.301 -8.825 1.00 1.00 H +ATOM 1865 H5'' C B 58 22.783 -2.021 -8.436 1.00 1.00 H +ATOM 1866 H4' C B 58 22.982 -0.635 -6.417 1.00 1.00 H +ATOM 1867 H3' C B 58 20.534 -2.404 -6.572 1.00 1.00 H +ATOM 1868 H2' C B 58 19.797 -1.585 -4.520 1.00 1.00 H +ATOM 1869 HO2' C B 58 21.152 -0.864 -2.945 1.00 1.00 H +ATOM 1870 H1' C B 58 20.881 1.011 -4.726 1.00 1.00 H +ATOM 1871 H41 C B 58 14.645 1.894 -5.730 1.00 1.00 H +ATOM 1872 H42 C B 58 14.715 0.951 -7.208 1.00 1.00 H +ATOM 1873 H5 C B 58 16.714 -0.148 -7.979 1.00 1.00 H +ATOM 1874 H6 C B 58 19.077 -0.593 -7.501 1.00 1.00 H +ATOM 1875 P C B 59 21.849 -4.337 -5.101 1.00 1.00 P +ATOM 1876 OP1 C B 59 23.032 -5.031 -4.543 1.00 1.00 O +ATOM 1877 OP2 C B 59 21.097 -4.942 -6.222 1.00 1.00 O +ATOM 1878 O5' C B 59 20.818 -4.050 -3.895 1.00 1.00 O +ATOM 1879 C5' C B 59 21.281 -3.468 -2.674 1.00 1.00 C +ATOM 1880 C4' C B 59 20.145 -2.824 -1.879 1.00 1.00 C +ATOM 1881 O4' C B 59 19.435 -1.909 -2.700 1.00 1.00 O +ATOM 1882 C3' C B 59 19.103 -3.791 -1.341 1.00 1.00 C +ATOM 1883 O3' C B 59 19.492 -4.235 -0.033 1.00 1.00 O +ATOM 1884 C2' C B 59 17.852 -2.931 -1.226 1.00 1.00 C +ATOM 1885 O2' C B 59 17.651 -2.475 0.115 1.00 1.00 O +ATOM 1886 C1' C B 59 18.107 -1.767 -2.186 1.00 1.00 C +ATOM 1887 N1 C B 59 17.155 -1.694 -3.319 1.00 1.00 N +ATOM 1888 C2 C B 59 16.095 -0.810 -3.191 1.00 1.00 C +ATOM 1889 O2 C B 59 15.974 -0.138 -2.169 1.00 1.00 O +ATOM 1890 N3 C B 59 15.205 -0.716 -4.216 1.00 1.00 N +ATOM 1891 C4 C B 59 15.347 -1.459 -5.321 1.00 1.00 C +ATOM 1892 N4 C B 59 14.457 -1.343 -6.306 1.00 1.00 N +ATOM 1893 C5 C B 59 16.438 -2.374 -5.457 1.00 1.00 C +ATOM 1894 C6 C B 59 17.314 -2.461 -4.438 1.00 1.00 C +ATOM 1895 H5' C B 59 22.026 -2.706 -2.906 1.00 1.00 H +ATOM 1896 H5'' C B 59 21.743 -4.243 -2.064 1.00 1.00 H +ATOM 1897 H4' C B 59 20.573 -2.270 -1.046 1.00 1.00 H +ATOM 1898 H3' C B 59 18.950 -4.629 -2.023 1.00 1.00 H +ATOM 1899 H2' C B 59 16.988 -3.505 -1.573 1.00 1.00 H +ATOM 1900 HO2' C B 59 18.518 -2.304 0.493 1.00 1.00 H +ATOM 1901 H1' C B 59 18.057 -0.835 -1.618 1.00 1.00 H +ATOM 1902 H41 C B 59 13.686 -0.699 -6.214 1.00 1.00 H +ATOM 1903 H42 C B 59 14.555 -1.898 -7.144 1.00 1.00 H +ATOM 1904 H5 C B 59 16.557 -2.979 -6.358 1.00 1.00 H +ATOM 1905 H6 C B 59 18.158 -3.147 -4.506 1.00 1.00 H +ATOM 1906 P G B 60 18.684 -5.411 0.714 1.00 1.00 P +ATOM 1907 OP1 G B 60 19.610 -6.072 1.662 1.00 1.00 O +ATOM 1908 OP2 G B 60 17.987 -6.215 -0.313 1.00 1.00 O +ATOM 1909 O5' G B 60 17.572 -4.610 1.572 1.00 1.00 O +ATOM 1910 C5' G B 60 17.951 -3.805 2.696 1.00 1.00 C +ATOM 1911 C4' G B 60 16.734 -3.226 3.426 1.00 1.00 C +ATOM 1912 O4' G B 60 16.091 -2.246 2.612 1.00 1.00 O +ATOM 1913 C3' G B 60 15.674 -4.256 3.794 1.00 1.00 C +ATOM 1914 O3' G B 60 15.905 -4.740 5.120 1.00 1.00 O +ATOM 1915 C2' G B 60 14.374 -3.469 3.758 1.00 1.00 C +ATOM 1916 O2' G B 60 14.036 -2.953 5.048 1.00 1.00 O +ATOM 1917 C1' G B 60 14.667 -2.346 2.771 1.00 1.00 C +ATOM 1918 N9 G B 60 14.098 -2.578 1.440 1.00 1.00 N +ATOM 1919 C8 G B 60 14.736 -3.016 0.309 1.00 1.00 C +ATOM 1920 N7 G B 60 13.954 -3.132 -0.729 1.00 1.00 N +ATOM 1921 C5 G B 60 12.705 -2.745 -0.253 1.00 1.00 C +ATOM 1922 C6 G B 60 11.456 -2.669 -0.929 1.00 1.00 C +ATOM 1923 O6 G B 60 11.206 -2.934 -2.102 1.00 1.00 O +ATOM 1924 N1 G B 60 10.446 -2.231 -0.084 1.00 1.00 N +ATOM 1925 C2 G B 60 10.612 -1.908 1.246 1.00 1.00 C +ATOM 1926 N2 G B 60 9.518 -1.507 1.896 1.00 1.00 N +ATOM 1927 N3 G B 60 11.785 -1.977 1.884 1.00 1.00 N +ATOM 1928 C4 G B 60 12.783 -2.403 1.074 1.00 1.00 C +ATOM 1929 H5' G B 60 18.577 -2.984 2.346 1.00 1.00 H +ATOM 1930 H5'' G B 60 18.525 -4.415 3.394 1.00 1.00 H +ATOM 1931 H4' G B 60 17.076 -2.738 4.337 1.00 1.00 H +ATOM 1932 H3' G B 60 15.656 -5.071 3.070 1.00 1.00 H +ATOM 1933 H2' G B 60 13.571 -4.100 3.372 1.00 1.00 H +ATOM 1934 HO2' G B 60 14.795 -2.460 5.366 1.00 1.00 H +ATOM 1935 H1' G B 60 14.279 -1.408 3.166 1.00 1.00 H +ATOM 1936 H8 G B 60 15.801 -3.246 0.278 1.00 1.00 H +ATOM 1937 H1 G B 60 9.526 -2.151 -0.495 1.00 1.00 H +ATOM 1938 H21 G B 60 8.633 -1.455 1.411 1.00 1.00 H +ATOM 1939 H22 G B 60 9.575 -1.256 2.872 1.00 1.00 H +ATOM 1940 P G B 61 15.256 -6.132 5.604 1.00 1.00 P +ATOM 1941 OP1 G B 61 15.747 -6.422 6.970 1.00 1.00 O +ATOM 1942 OP2 G B 61 15.441 -7.129 4.526 1.00 1.00 O +ATOM 1943 O5' G B 61 13.686 -5.775 5.697 1.00 1.00 O +ATOM 1944 C5' G B 61 13.216 -4.787 6.621 1.00 1.00 C +ATOM 1945 C4' G B 61 11.707 -4.571 6.501 1.00 1.00 C +ATOM 1946 O4' G B 61 11.389 -4.057 5.211 1.00 1.00 O +ATOM 1947 C3' G B 61 10.875 -5.830 6.683 1.00 1.00 C +ATOM 1948 O3' G B 61 10.534 -5.979 8.068 1.00 1.00 O +ATOM 1949 C2' G B 61 9.626 -5.556 5.857 1.00 1.00 C +ATOM 1950 O2' G B 61 8.569 -5.033 6.670 1.00 1.00 O +ATOM 1951 C1' G B 61 10.092 -4.532 4.819 1.00 1.00 C +ATOM 1952 N9 G B 61 10.219 -5.081 3.458 1.00 1.00 N +ATOM 1953 C8 G B 61 11.283 -5.743 2.903 1.00 1.00 C +ATOM 1954 N7 G B 61 11.088 -6.115 1.669 1.00 1.00 N +ATOM 1955 C5 G B 61 9.801 -5.669 1.382 1.00 1.00 C +ATOM 1956 C6 G B 61 9.042 -5.786 0.183 1.00 1.00 C +ATOM 1957 O6 G B 61 9.365 -6.318 -0.876 1.00 1.00 O +ATOM 1958 N1 G B 61 7.790 -5.200 0.315 1.00 1.00 N +ATOM 1959 C2 G B 61 7.324 -4.579 1.454 1.00 1.00 C +ATOM 1960 N2 G B 61 6.091 -4.075 1.386 1.00 1.00 N +ATOM 1961 N3 G B 61 8.034 -4.467 2.581 1.00 1.00 N +ATOM 1962 C4 G B 61 9.260 -5.034 2.472 1.00 1.00 C +ATOM 1963 H5' G B 61 13.725 -3.845 6.420 1.00 1.00 H +ATOM 1964 H5'' G B 61 13.449 -5.108 7.635 1.00 1.00 H +ATOM 1965 H4' G B 61 11.400 -3.839 7.245 1.00 1.00 H +ATOM 1966 H3' G B 61 11.407 -6.706 6.306 1.00 1.00 H +ATOM 1967 H2' G B 61 9.308 -6.472 5.355 1.00 1.00 H +ATOM 1968 HO2' G B 61 8.188 -4.289 6.197 1.00 1.00 H +ATOM 1969 H1' G B 61 9.392 -3.696 4.802 1.00 1.00 H +ATOM 1970 H8 G B 61 12.209 -5.939 3.443 1.00 1.00 H +ATOM 1971 H1 G B 61 7.192 -5.244 -0.498 1.00 1.00 H +ATOM 1972 H21 G B 61 5.557 -4.161 0.533 1.00 1.00 H +ATOM 1973 H22 G B 61 5.692 -3.607 2.186 1.00 1.00 H +ATOM 1974 P G B 62 10.104 -7.413 8.666 1.00 1.00 P +ATOM 1975 OP1 G B 62 10.072 -7.305 10.142 1.00 1.00 O +ATOM 1976 OP2 G B 62 10.938 -8.452 8.022 1.00 1.00 O +ATOM 1977 O5' G B 62 8.591 -7.583 8.140 1.00 1.00 O +ATOM 1978 C5' G B 62 7.557 -6.707 8.601 1.00 1.00 C +ATOM 1979 C4' G B 62 6.283 -6.858 7.774 1.00 1.00 C +ATOM 1980 O4' G B 62 6.568 -6.602 6.403 1.00 1.00 O +ATOM 1981 C3' G B 62 5.655 -8.239 7.841 1.00 1.00 C +ATOM 1982 O3' G B 62 4.691 -8.270 8.901 1.00 1.00 O +ATOM 1983 C2' G B 62 4.962 -8.384 6.492 1.00 1.00 C +ATOM 1984 O2' G B 62 3.584 -8.002 6.570 1.00 1.00 O +ATOM 1985 C1' G B 62 5.752 -7.443 5.577 1.00 1.00 C +ATOM 1986 N9 G B 62 6.653 -8.137 4.638 1.00 1.00 N +ATOM 1987 C8 G B 62 7.919 -8.613 4.857 1.00 1.00 C +ATOM 1988 N7 G B 62 8.456 -9.185 3.817 1.00 1.00 N +ATOM 1989 C5 G B 62 7.477 -9.081 2.834 1.00 1.00 C +ATOM 1990 C6 G B 62 7.491 -9.527 1.482 1.00 1.00 C +ATOM 1991 O6 G B 62 8.389 -10.111 0.881 1.00 1.00 O +ATOM 1992 N1 G B 62 6.301 -9.223 0.835 1.00 1.00 N +ATOM 1993 C2 G B 62 5.231 -8.572 1.410 1.00 1.00 C +ATOM 1994 N2 G B 62 4.173 -8.369 0.625 1.00 1.00 N +ATOM 1995 N3 G B 62 5.215 -8.153 2.679 1.00 1.00 N +ATOM 1996 C4 G B 62 6.369 -8.440 3.328 1.00 1.00 C +ATOM 1997 H5' G B 62 7.906 -5.677 8.532 1.00 1.00 H +ATOM 1998 H5'' G B 62 7.333 -6.938 9.642 1.00 1.00 H +ATOM 1999 H4' G B 62 5.554 -6.125 8.115 1.00 1.00 H +ATOM 2000 H3' G B 62 6.419 -9.007 7.974 1.00 1.00 H +ATOM 2001 H2' G B 62 5.058 -9.414 6.136 1.00 1.00 H +ATOM 2002 HO2' G B 62 3.092 -8.586 5.986 1.00 1.00 H +ATOM 2003 H1' G B 62 5.057 -6.823 5.006 1.00 1.00 H +ATOM 2004 H8 G B 62 8.431 -8.522 5.815 1.00 1.00 H +ATOM 2005 H1 G B 62 6.236 -9.509 -0.132 1.00 1.00 H +ATOM 2006 H21 G B 62 4.186 -8.687 -0.334 1.00 1.00 H +ATOM 2007 H22 G B 62 3.357 -7.898 0.990 1.00 1.00 H +ATOM 2008 P G B 63 4.488 -9.598 9.790 1.00 1.00 P +ATOM 2009 OP1 G B 63 3.746 -9.225 11.015 1.00 1.00 O +ATOM 2010 OP2 G B 63 5.792 -10.288 9.899 1.00 1.00 O +ATOM 2011 O5' G B 63 3.520 -10.494 8.869 1.00 1.00 O +ATOM 2012 C5' G B 63 3.667 -11.915 8.838 1.00 1.00 C +ATOM 2013 C4' G B 63 3.164 -12.498 7.524 1.00 1.00 C +ATOM 2014 O4' G B 63 3.622 -11.694 6.434 1.00 1.00 O +ATOM 2015 C3' G B 63 3.631 -13.923 7.268 1.00 1.00 C +ATOM 2016 O3' G B 63 2.609 -14.839 7.675 1.00 1.00 O +ATOM 2017 C2' G B 63 3.806 -13.981 5.760 1.00 1.00 C +ATOM 2018 O2' G B 63 2.612 -14.437 5.117 1.00 1.00 O +ATOM 2019 C1' G B 63 4.120 -12.534 5.386 1.00 1.00 C +ATOM 2020 N9 G B 63 5.561 -12.247 5.242 1.00 1.00 N +ATOM 2021 C8 G B 63 6.463 -11.902 6.215 1.00 1.00 C +ATOM 2022 N7 G B 63 7.674 -11.713 5.770 1.00 1.00 N +ATOM 2023 C5 G B 63 7.570 -11.949 4.403 1.00 1.00 C +ATOM 2024 C6 G B 63 8.568 -11.894 3.393 1.00 1.00 C +ATOM 2025 O6 G B 63 9.762 -11.624 3.512 1.00 1.00 O +ATOM 2026 N1 G B 63 8.046 -12.199 2.144 1.00 1.00 N +ATOM 2027 C2 G B 63 6.728 -12.518 1.894 1.00 1.00 C +ATOM 2028 N2 G B 63 6.419 -12.780 0.625 1.00 1.00 N +ATOM 2029 N3 G B 63 5.786 -12.571 2.842 1.00 1.00 N +ATOM 2030 C4 G B 63 6.279 -12.276 4.069 1.00 1.00 C +ATOM 2031 H5' G B 63 3.098 -12.348 9.660 1.00 1.00 H +ATOM 2032 H5'' G B 63 4.719 -12.167 8.962 1.00 1.00 H +ATOM 2033 H4' G B 63 2.075 -12.483 7.528 1.00 1.00 H +ATOM 2034 H3' G B 63 4.574 -14.123 7.780 1.00 1.00 H +ATOM 2035 H2' G B 63 4.653 -14.625 5.507 1.00 1.00 H +ATOM 2036 HO2' G B 63 2.172 -13.666 4.751 1.00 1.00 H +ATOM 2037 H1' G B 63 3.613 -12.286 4.453 1.00 1.00 H +ATOM 2038 H8 G B 63 6.193 -11.794 7.265 1.00 1.00 H +ATOM 2039 H1 G B 63 8.697 -12.181 1.373 1.00 1.00 H +ATOM 2040 H21 G B 63 7.132 -12.739 -0.089 1.00 1.00 H +ATOM 2041 H22 G B 63 5.472 -13.019 0.377 1.00 1.00 H +ATOM 2042 P A B 64 2.955 -16.074 8.649 1.00 1.00 P +ATOM 2043 OP1 A B 64 1.688 -16.745 9.016 1.00 1.00 O +ATOM 2044 OP2 A B 64 3.866 -15.587 9.709 1.00 1.00 O +ATOM 2045 O5' A B 64 3.788 -17.062 7.687 1.00 1.00 O +ATOM 2046 C5' A B 64 4.814 -17.902 8.222 1.00 1.00 C +ATOM 2047 C4' A B 64 5.248 -18.966 7.217 1.00 1.00 C +ATOM 2048 O4' A B 64 4.181 -19.900 7.023 1.00 1.00 O +ATOM 2049 C3' A B 64 5.628 -18.400 5.852 1.00 1.00 C +ATOM 2050 O3' A B 64 7.054 -18.393 5.722 1.00 1.00 O +ATOM 2051 C2' A B 64 5.024 -19.378 4.856 1.00 1.00 C +ATOM 2052 O2' A B 64 5.977 -20.368 4.453 1.00 1.00 O +ATOM 2053 C1' A B 64 3.870 -20.002 5.629 1.00 1.00 C +ATOM 2054 N9 A B 64 2.571 -19.337 5.414 1.00 1.00 N +ATOM 2055 C8 A B 64 1.897 -18.487 6.253 1.00 1.00 C +ATOM 2056 N7 A B 64 0.760 -18.064 5.774 1.00 1.00 N +ATOM 2057 C5 A B 64 0.673 -18.680 4.529 1.00 1.00 C +ATOM 2058 C6 A B 64 -0.302 -18.639 3.519 1.00 1.00 C +ATOM 2059 N6 A B 64 -1.420 -17.919 3.612 1.00 1.00 N +ATOM 2060 N1 A B 64 -0.074 -19.368 2.415 1.00 1.00 N +ATOM 2061 C2 A B 64 1.043 -20.081 2.328 1.00 1.00 C +ATOM 2062 N3 A B 64 2.030 -20.199 3.204 1.00 1.00 N +ATOM 2063 C4 A B 64 1.772 -19.457 4.301 1.00 1.00 C +ATOM 2064 H5' A B 64 4.441 -18.392 9.121 1.00 1.00 H +ATOM 2065 H5'' A B 64 5.676 -17.288 8.483 1.00 1.00 H +ATOM 2066 H4' A B 64 6.103 -19.502 7.624 1.00 1.00 H +ATOM 2067 H3' A B 64 5.213 -17.400 5.716 1.00 1.00 H +ATOM 2068 H2' A B 64 4.640 -18.837 3.989 1.00 1.00 H +ATOM 2069 HO2' A B 64 6.690 -20.357 5.095 1.00 1.00 H +ATOM 2070 H1' A B 64 3.782 -21.053 5.357 1.00 1.00 H +ATOM 2071 H8 A B 64 2.277 -18.192 7.230 1.00 1.00 H +ATOM 2072 H61 A B 64 -2.089 -17.925 2.856 1.00 1.00 H +ATOM 2073 H62 A B 64 -1.597 -17.368 4.441 1.00 1.00 H +ATOM 2074 H2 A B 64 1.164 -20.649 1.405 1.00 1.00 H +ATOM 2075 P A B 65 7.790 -17.305 4.790 1.00 1.00 P +ATOM 2076 OP1 A B 65 9.086 -16.961 5.415 1.00 1.00 O +ATOM 2077 OP2 A B 65 6.817 -16.236 4.472 1.00 1.00 O +ATOM 2078 O5' A B 65 8.086 -18.135 3.443 1.00 1.00 O +ATOM 2079 C5' A B 65 7.742 -17.591 2.166 1.00 1.00 C +ATOM 2080 C4' A B 65 6.805 -18.518 1.403 1.00 1.00 C +ATOM 2081 O4' A B 65 5.645 -18.781 2.199 1.00 1.00 O +ATOM 2082 C3' A B 65 6.331 -17.955 0.068 1.00 1.00 C +ATOM 2083 O3' A B 65 7.113 -18.512 -0.994 1.00 1.00 O +ATOM 2084 C2' A B 65 4.894 -18.441 -0.040 1.00 1.00 C +ATOM 2085 O2' A B 65 4.818 -19.695 -0.725 1.00 1.00 O +ATOM 2086 C1' A B 65 4.464 -18.577 1.416 1.00 1.00 C +ATOM 2087 N9 A B 65 3.775 -17.390 1.955 1.00 1.00 N +ATOM 2088 C8 A B 65 4.203 -16.509 2.914 1.00 1.00 C +ATOM 2089 N7 A B 65 3.346 -15.560 3.178 1.00 1.00 N +ATOM 2090 C5 A B 65 2.274 -15.836 2.333 1.00 1.00 C +ATOM 2091 C6 A B 65 1.039 -15.201 2.124 1.00 1.00 C +ATOM 2092 N6 A B 65 0.660 -14.105 2.783 1.00 1.00 N +ATOM 2093 N1 A B 65 0.214 -15.741 1.210 1.00 1.00 N +ATOM 2094 C2 A B 65 0.596 -16.832 0.558 1.00 1.00 C +ATOM 2095 N3 A B 65 1.724 -17.516 0.664 1.00 1.00 N +ATOM 2096 C4 A B 65 2.529 -16.950 1.587 1.00 1.00 C +ATOM 2097 H5' A B 65 8.652 -17.445 1.584 1.00 1.00 H +ATOM 2098 H5'' A B 65 7.252 -16.628 2.309 1.00 1.00 H +ATOM 2099 H4' A B 65 7.317 -19.462 1.222 1.00 1.00 H +ATOM 2100 H3' A B 65 6.375 -16.864 0.067 1.00 1.00 H +ATOM 2101 H2' A B 65 4.282 -17.687 -0.542 1.00 1.00 H +ATOM 2102 HO2' A B 65 5.640 -19.808 -1.209 1.00 1.00 H +ATOM 2103 H1' A B 65 3.811 -19.443 1.520 1.00 1.00 H +ATOM 2104 H8 A B 65 5.172 -16.591 3.410 1.00 1.00 H +ATOM 2105 H61 A B 65 -0.240 -13.688 2.594 1.00 1.00 H +ATOM 2106 H62 A B 65 1.274 -13.693 3.471 1.00 1.00 H +ATOM 2107 H2 A B 65 -0.119 -17.219 -0.168 1.00 1.00 H +ATOM 2108 P A B 66 7.789 -17.558 -2.102 1.00 1.00 P +ATOM 2109 OP1 A B 66 8.547 -18.409 -3.046 1.00 1.00 O +ATOM 2110 OP2 A B 66 8.470 -16.445 -1.402 1.00 1.00 O +ATOM 2111 O5' A B 66 6.512 -16.960 -2.879 1.00 1.00 O +ATOM 2112 C5' A B 66 6.159 -17.446 -4.177 1.00 1.00 C +ATOM 2113 C4' A B 66 4.711 -17.108 -4.524 1.00 1.00 C +ATOM 2114 O4' A B 66 3.901 -17.236 -3.354 1.00 1.00 O +ATOM 2115 C3' A B 66 4.515 -15.695 -5.058 1.00 1.00 C +ATOM 2116 O3' A B 66 4.494 -15.722 -6.490 1.00 1.00 O +ATOM 2117 C2' A B 66 3.143 -15.301 -4.534 1.00 1.00 C +ATOM 2118 O2' A B 66 2.113 -15.627 -5.474 1.00 1.00 O +ATOM 2119 C1' A B 66 3.006 -16.120 -3.257 1.00 1.00 C +ATOM 2120 N9 A B 66 3.353 -15.373 -2.035 1.00 1.00 N +ATOM 2121 C8 A B 66 4.567 -15.257 -1.411 1.00 1.00 C +ATOM 2122 N7 A B 66 4.547 -14.496 -0.352 1.00 1.00 N +ATOM 2123 C5 A B 66 3.222 -14.080 -0.267 1.00 1.00 C +ATOM 2124 C6 A B 66 2.544 -13.249 0.639 1.00 1.00 C +ATOM 2125 N6 A B 66 3.139 -12.662 1.678 1.00 1.00 N +ATOM 2126 N1 A B 66 1.233 -13.050 0.430 1.00 1.00 N +ATOM 2127 C2 A B 66 0.647 -13.632 -0.609 1.00 1.00 C +ATOM 2128 N3 A B 66 1.173 -14.427 -1.528 1.00 1.00 N +ATOM 2129 C4 A B 66 2.488 -14.610 -1.289 1.00 1.00 C +ATOM 2130 H5' A B 66 6.287 -18.527 -4.200 1.00 1.00 H +ATOM 2131 H5'' A B 66 6.817 -16.992 -4.917 1.00 1.00 H +ATOM 2132 H4' A B 66 4.354 -17.818 -5.268 1.00 1.00 H +ATOM 2133 H3' A B 66 5.287 -15.022 -4.681 1.00 1.00 H +ATOM 2134 H2' A B 66 3.127 -14.235 -4.295 1.00 1.00 H +ATOM 2135 HO2' A B 66 2.525 -16.108 -6.195 1.00 1.00 H +ATOM 2136 H1' A B 66 1.983 -16.485 -3.173 1.00 1.00 H +ATOM 2137 H8 A B 66 5.469 -15.755 -1.768 1.00 1.00 H +ATOM 2138 H61 A B 66 2.601 -12.073 2.300 1.00 1.00 H +ATOM 2139 H62 A B 66 4.126 -12.805 1.845 1.00 1.00 H +ATOM 2140 H2 A B 66 -0.417 -13.427 -0.721 1.00 1.00 H +ATOM 2141 P C B 67 5.217 -14.563 -7.347 1.00 1.00 P +ATOM 2142 OP1 C B 67 4.888 -14.771 -8.774 1.00 1.00 O +ATOM 2143 OP2 C B 67 6.632 -14.489 -6.920 1.00 1.00 O +ATOM 2144 O5' C B 67 4.467 -13.229 -6.846 1.00 1.00 O +ATOM 2145 C5' C B 67 3.070 -13.047 -7.082 1.00 1.00 C +ATOM 2146 C4' C B 67 2.480 -11.985 -6.156 1.00 1.00 C +ATOM 2147 O4' C B 67 2.788 -12.305 -4.800 1.00 1.00 O +ATOM 2148 C3' C B 67 3.006 -10.579 -6.402 1.00 1.00 C +ATOM 2149 O3' C B 67 2.150 -9.892 -7.318 1.00 1.00 O +ATOM 2150 C2' C B 67 2.922 -9.925 -5.034 1.00 1.00 C +ATOM 2151 O2' C B 67 1.676 -9.240 -4.859 1.00 1.00 O +ATOM 2152 C1' C B 67 3.055 -11.098 -4.071 1.00 1.00 C +ATOM 2153 N1 C B 67 4.399 -11.222 -3.474 1.00 1.00 N +ATOM 2154 C2 C B 67 4.615 -10.611 -2.249 1.00 1.00 C +ATOM 2155 O2 C B 67 3.705 -9.993 -1.700 1.00 1.00 O +ATOM 2156 N3 C B 67 5.850 -10.715 -1.685 1.00 1.00 N +ATOM 2157 C4 C B 67 6.831 -11.391 -2.297 1.00 1.00 C +ATOM 2158 N4 C B 67 8.029 -11.475 -1.717 1.00 1.00 N +ATOM 2159 C5 C B 67 6.612 -12.023 -3.562 1.00 1.00 C +ATOM 2160 C6 C B 67 5.387 -11.915 -4.111 1.00 1.00 C +ATOM 2161 H5' C B 67 2.554 -13.992 -6.911 1.00 1.00 H +ATOM 2162 H5'' C B 67 2.919 -12.740 -8.116 1.00 1.00 H +ATOM 2163 H4' C B 67 1.398 -11.981 -6.270 1.00 1.00 H +ATOM 2164 H3' C B 67 4.037 -10.604 -6.759 1.00 1.00 H +ATOM 2165 H2' C B 67 3.760 -9.240 -4.899 1.00 1.00 H +ATOM 2166 HO2' C B 67 1.598 -9.026 -3.927 1.00 1.00 H +ATOM 2167 H1' C B 67 2.318 -10.990 -3.277 1.00 1.00 H +ATOM 2168 H41 C B 67 8.189 -11.032 -0.826 1.00 1.00 H +ATOM 2169 H42 C B 67 8.775 -11.982 -2.170 1.00 1.00 H +ATOM 2170 H5 C B 67 7.408 -12.573 -4.064 1.00 1.00 H +ATOM 2171 H6 C B 67 5.183 -12.384 -5.074 1.00 1.00 H +ATOM 2172 P U B 68 2.678 -8.595 -8.115 1.00 1.00 P +ATOM 2173 OP1 U B 68 1.616 -8.165 -9.052 1.00 1.00 O +ATOM 2174 OP2 U B 68 4.037 -8.887 -8.624 1.00 1.00 O +ATOM 2175 O5' U B 68 2.803 -7.489 -6.949 1.00 1.00 O +ATOM 2176 C5' U B 68 1.643 -7.054 -6.231 1.00 1.00 C +ATOM 2177 C4' U B 68 2.016 -6.225 -5.000 1.00 1.00 C +ATOM 2178 O4' U B 68 2.893 -6.971 -4.160 1.00 1.00 O +ATOM 2179 C3' U B 68 2.729 -4.919 -5.311 1.00 1.00 C +ATOM 2180 O3' U B 68 1.774 -3.865 -5.472 1.00 1.00 O +ATOM 2181 C2' U B 68 3.571 -4.672 -4.071 1.00 1.00 C +ATOM 2182 O2' U B 68 2.886 -3.838 -3.131 1.00 1.00 O +ATOM 2183 C1' U B 68 3.804 -6.072 -3.507 1.00 1.00 C +ATOM 2184 N1 U B 68 5.172 -6.583 -3.735 1.00 1.00 N +ATOM 2185 C2 U B 68 6.108 -6.393 -2.735 1.00 1.00 C +ATOM 2186 O2 U B 68 5.835 -5.813 -1.686 1.00 1.00 O +ATOM 2187 N3 U B 68 7.374 -6.892 -2.985 1.00 1.00 N +ATOM 2188 C4 U B 68 7.778 -7.557 -4.130 1.00 1.00 C +ATOM 2189 O4 U B 68 8.934 -7.959 -4.247 1.00 1.00 O +ATOM 2190 C5 U B 68 6.736 -7.711 -5.120 1.00 1.00 C +ATOM 2191 C6 U B 68 5.489 -7.231 -4.898 1.00 1.00 C +ATOM 2192 H5' U B 68 1.076 -7.928 -5.910 1.00 1.00 H +ATOM 2193 H5'' U B 68 1.023 -6.449 -6.891 1.00 1.00 H +ATOM 2194 H4' U B 68 1.111 -6.005 -4.438 1.00 1.00 H +ATOM 2195 H3' U B 68 3.361 -5.023 -6.196 1.00 1.00 H +ATOM 2196 H2' U B 68 4.522 -4.226 -4.356 1.00 1.00 H +ATOM 2197 HO2' U B 68 3.554 -3.334 -2.661 1.00 1.00 H +ATOM 2198 H1' U B 68 3.595 -6.065 -2.436 1.00 1.00 H +ATOM 2199 H3 U B 68 8.068 -6.760 -2.264 1.00 1.00 H +ATOM 2200 H5 U B 68 6.956 -8.221 -6.058 1.00 1.00 H +ATOM 2201 H6 U B 68 4.722 -7.360 -5.662 1.00 1.00 H +ATOM 2202 P U B 69 2.183 -2.494 -6.216 1.00 1.00 P +ATOM 2203 OP1 U B 69 0.940 -1.775 -6.576 1.00 1.00 O +ATOM 2204 OP2 U B 69 3.178 -2.815 -7.263 1.00 1.00 O +ATOM 2205 O5' U B 69 2.926 -1.655 -5.056 1.00 1.00 O +ATOM 2206 C5' U B 69 2.205 -1.208 -3.903 1.00 1.00 C +ATOM 2207 C4' U B 69 3.143 -0.812 -2.764 1.00 1.00 C +ATOM 2208 O4' U B 69 3.994 -1.907 -2.432 1.00 1.00 O +ATOM 2209 C3' U B 69 4.063 0.355 -3.074 1.00 1.00 C +ATOM 2210 O3' U B 69 3.407 1.593 -2.753 1.00 1.00 O +ATOM 2211 C2' U B 69 5.247 0.111 -2.143 1.00 1.00 C +ATOM 2212 O2' U B 69 5.079 0.771 -0.885 1.00 1.00 O +ATOM 2213 C1' U B 69 5.260 -1.404 -1.968 1.00 1.00 C +ATOM 2214 N1 U B 69 6.317 -2.066 -2.756 1.00 1.00 N +ATOM 2215 C2 U B 69 7.496 -2.405 -2.118 1.00 1.00 C +ATOM 2216 O2 U B 69 7.688 -2.165 -0.927 1.00 1.00 O +ATOM 2217 N3 U B 69 8.452 -3.028 -2.900 1.00 1.00 N +ATOM 2218 C4 U B 69 8.331 -3.339 -4.245 1.00 1.00 C +ATOM 2219 O4 U B 69 9.248 -3.897 -4.843 1.00 1.00 O +ATOM 2220 C5 U B 69 7.067 -2.948 -4.828 1.00 1.00 C +ATOM 2221 C6 U B 69 6.116 -2.337 -4.081 1.00 1.00 C +ATOM 2222 H5' U B 69 1.550 -2.010 -3.560 1.00 1.00 H +ATOM 2223 H5'' U B 69 1.597 -0.347 -4.177 1.00 1.00 H +ATOM 2224 H4' U B 69 2.546 -0.567 -1.887 1.00 1.00 H +ATOM 2225 H3' U B 69 4.379 0.330 -4.119 1.00 1.00 H +ATOM 2226 H2' U B 69 6.168 0.427 -2.630 1.00 1.00 H +ATOM 2227 HO2' U B 69 4.264 0.444 -0.497 1.00 1.00 H +ATOM 2228 H1' U B 69 5.382 -1.646 -0.912 1.00 1.00 H +ATOM 2229 H3 U B 69 9.319 -3.282 -2.448 1.00 1.00 H +ATOM 2230 H5 U B 69 6.877 -3.146 -5.882 1.00 1.00 H +ATOM 2231 H6 U B 69 5.170 -2.056 -4.545 1.00 1.00 H +ATOM 2232 P G B 70 3.916 2.992 -3.379 1.00 1.00 P +ATOM 2233 OP1 G B 70 2.963 4.053 -2.980 1.00 1.00 O +ATOM 2234 OP2 G B 70 4.232 2.779 -4.808 1.00 1.00 O +ATOM 2235 O5' G B 70 5.293 3.230 -2.587 1.00 1.00 O +ATOM 2236 C5' G B 70 5.286 3.251 -1.162 1.00 1.00 C +ATOM 2237 C4' G B 70 6.662 2.939 -0.587 1.00 1.00 C +ATOM 2238 O4' G B 70 7.163 1.754 -1.203 1.00 1.00 O +ATOM 2239 C3' G B 70 7.720 4.011 -0.809 1.00 1.00 C +ATOM 2240 O3' G B 70 7.741 4.903 0.315 1.00 1.00 O +ATOM 2241 C2' G B 70 9.017 3.223 -0.834 1.00 1.00 C +ATOM 2242 O2' G B 70 9.669 3.265 0.439 1.00 1.00 O +ATOM 2243 C1' G B 70 8.591 1.801 -1.192 1.00 1.00 C +ATOM 2244 N9 G B 70 9.114 1.329 -2.486 1.00 1.00 N +ATOM 2245 C8 G B 70 8.527 1.320 -3.726 1.00 1.00 C +ATOM 2246 N7 G B 70 9.262 0.773 -4.654 1.00 1.00 N +ATOM 2247 C5 G B 70 10.422 0.395 -3.983 1.00 1.00 C +ATOM 2248 C6 G B 70 11.590 -0.250 -4.472 1.00 1.00 C +ATOM 2249 O6 G B 70 11.832 -0.627 -5.618 1.00 1.00 O +ATOM 2250 N1 G B 70 12.525 -0.445 -3.463 1.00 1.00 N +ATOM 2251 C2 G B 70 12.357 -0.068 -2.147 1.00 1.00 C +ATOM 2252 N2 G B 70 13.368 -0.333 -1.323 1.00 1.00 N +ATOM 2253 N3 G B 70 11.259 0.536 -1.686 1.00 1.00 N +ATOM 2254 C4 G B 70 10.339 0.735 -2.656 1.00 1.00 C +ATOM 2255 H5' G B 70 4.575 2.507 -0.799 1.00 1.00 H +ATOM 2256 H5'' G B 70 4.975 4.238 -0.822 1.00 1.00 H +ATOM 2257 H4' G B 70 6.565 2.754 0.479 1.00 1.00 H +ATOM 2258 H3' G B 70 7.557 4.544 -1.748 1.00 1.00 H +ATOM 2259 H2' G B 70 9.674 3.619 -1.612 1.00 1.00 H +ATOM 2260 HO2' G B 70 9.154 2.720 1.042 1.00 1.00 H +ATOM 2261 H1' G B 70 8.946 1.123 -0.417 1.00 1.00 H +ATOM 2262 H8 G B 70 7.538 1.736 -3.920 1.00 1.00 H +ATOM 2263 H1 G B 70 13.383 -0.903 -3.735 1.00 1.00 H +ATOM 2264 H21 G B 70 14.203 -0.789 -1.672 1.00 1.00 H +ATOM 2265 H22 G B 70 13.302 -0.080 -0.347 1.00 1.00 H +ATOM 2266 P G B 71 8.643 6.240 0.296 1.00 1.00 P +ATOM 2267 OP1 G B 71 8.101 7.177 1.306 1.00 1.00 O +ATOM 2268 OP2 G B 71 8.784 6.678 -1.111 1.00 1.00 O +ATOM 2269 O5' G B 71 10.088 5.724 0.812 1.00 1.00 O +ATOM 2270 C5' G B 71 10.339 5.508 2.209 1.00 1.00 C +ATOM 2271 C4' G B 71 11.839 5.512 2.529 1.00 1.00 C +ATOM 2272 O4' G B 71 12.399 4.209 2.329 1.00 1.00 O +ATOM 2273 C3' G B 71 12.644 6.484 1.679 1.00 1.00 C +ATOM 2274 O3' G B 71 12.807 7.716 2.388 1.00 1.00 O +ATOM 2275 C2' G B 71 13.988 5.792 1.509 1.00 1.00 C +ATOM 2276 O2' G B 71 14.906 6.158 2.543 1.00 1.00 O +ATOM 2277 C1' G B 71 13.623 4.318 1.584 1.00 1.00 C +ATOM 2278 N9 G B 71 13.372 3.711 0.272 1.00 1.00 N +ATOM 2279 C8 G B 71 12.164 3.333 -0.256 1.00 1.00 C +ATOM 2280 N7 G B 71 12.242 2.844 -1.460 1.00 1.00 N +ATOM 2281 C5 G B 71 13.601 2.898 -1.757 1.00 1.00 C +ATOM 2282 C6 G B 71 14.289 2.500 -2.935 1.00 1.00 C +ATOM 2283 O6 G B 71 13.823 2.015 -3.964 1.00 1.00 O +ATOM 2284 N1 G B 71 15.654 2.722 -2.827 1.00 1.00 N +ATOM 2285 C2 G B 71 16.283 3.260 -1.724 1.00 1.00 C +ATOM 2286 N2 G B 71 17.605 3.395 -1.809 1.00 1.00 N +ATOM 2287 N3 G B 71 15.638 3.637 -0.614 1.00 1.00 N +ATOM 2288 C4 G B 71 14.302 3.427 -0.702 1.00 1.00 C +ATOM 2289 H5' G B 71 9.916 4.548 2.501 1.00 1.00 H +ATOM 2290 H5'' G B 71 9.853 6.299 2.782 1.00 1.00 H +ATOM 2291 H4' G B 71 11.967 5.782 3.576 1.00 1.00 H +ATOM 2292 H3' G B 71 12.164 6.643 0.712 1.00 1.00 H +ATOM 2293 H2' G B 71 14.402 6.019 0.525 1.00 1.00 H +ATOM 2294 HO2' G B 71 15.783 6.167 2.153 1.00 1.00 H +ATOM 2295 H1' G B 71 14.413 3.768 2.093 1.00 1.00 H +ATOM 2296 H8 G B 71 11.223 3.430 0.285 1.00 1.00 H +ATOM 2297 H1 G B 71 16.212 2.463 -3.627 1.00 1.00 H +ATOM 2298 H21 G B 71 18.091 3.109 -2.650 1.00 1.00 H +ATOM 2299 H22 G B 71 18.125 3.782 -1.034 1.00 1.00 H +ATOM 2300 P U B 72 12.814 9.117 1.599 1.00 1.00 P +ATOM 2301 OP1 U B 72 12.775 10.209 2.597 1.00 1.00 O +ATOM 2302 OP2 U B 72 11.785 9.051 0.536 1.00 1.00 O +ATOM 2303 O5' U B 72 14.262 9.124 0.898 1.00 1.00 O +ATOM 2304 C5' U B 72 15.451 9.250 1.683 1.00 1.00 C +ATOM 2305 C4' U B 72 16.698 9.253 0.805 1.00 1.00 C +ATOM 2306 O4' U B 72 16.887 7.968 0.213 1.00 1.00 O +ATOM 2307 C3' U B 72 16.644 10.253 -0.338 1.00 1.00 C +ATOM 2308 O3' U B 72 17.172 11.515 0.094 1.00 1.00 O +ATOM 2309 C2' U B 72 17.548 9.623 -1.384 1.00 1.00 C +ATOM 2310 O2' U B 72 18.910 10.033 -1.221 1.00 1.00 O +ATOM 2311 C1' U B 72 17.378 8.127 -1.127 1.00 1.00 C +ATOM 2312 N1 U B 72 16.406 7.471 -2.027 1.00 1.00 N +ATOM 2313 C2 U B 72 16.884 6.918 -3.200 1.00 1.00 C +ATOM 2314 O2 U B 72 18.071 6.974 -3.513 1.00 1.00 O +ATOM 2315 N3 U B 72 15.945 6.295 -4.003 1.00 1.00 N +ATOM 2316 C4 U B 72 14.591 6.180 -3.740 1.00 1.00 C +ATOM 2317 O4 U B 72 13.846 5.604 -4.529 1.00 1.00 O +ATOM 2318 C5 U B 72 14.180 6.787 -2.494 1.00 1.00 C +ATOM 2319 C6 U B 72 15.081 7.402 -1.689 1.00 1.00 C +ATOM 2320 H5' U B 72 15.508 8.414 2.380 1.00 1.00 H +ATOM 2321 H5'' U B 72 15.408 10.182 2.246 1.00 1.00 H +ATOM 2322 H4' U B 72 17.564 9.475 1.426 1.00 1.00 H +ATOM 2323 H3' U B 72 15.625 10.356 -0.715 1.00 1.00 H +ATOM 2324 H2' U B 72 17.188 9.866 -2.380 1.00 1.00 H +ATOM 2325 HO2' U B 72 19.204 9.717 -0.365 1.00 1.00 H +ATOM 2326 H1' U B 72 18.345 7.634 -1.218 1.00 1.00 H +ATOM 2327 H3 U B 72 16.280 5.885 -4.864 1.00 1.00 H +ATOM 2328 H5 U B 72 13.133 6.750 -2.198 1.00 1.00 H +ATOM 2329 H6 U B 72 14.743 7.852 -0.756 1.00 1.00 H +ATOM 2330 P U B 73 16.648 12.894 -0.559 1.00 1.00 P +ATOM 2331 OP1 U B 73 17.178 14.015 0.249 1.00 1.00 O +ATOM 2332 OP2 U B 73 15.189 12.773 -0.780 1.00 1.00 O +ATOM 2333 O5' U B 73 17.374 12.923 -1.999 1.00 1.00 O +ATOM 2334 C5' U B 73 18.788 13.124 -2.096 1.00 1.00 C +ATOM 2335 C4' U B 73 19.292 12.923 -3.525 1.00 1.00 C +ATOM 2336 O4' U B 73 19.080 11.575 -3.930 1.00 1.00 O +ATOM 2337 C3' U B 73 18.609 13.792 -4.569 1.00 1.00 C +ATOM 2338 O3' U B 73 19.276 15.056 -4.675 1.00 1.00 O +ATOM 2339 C2' U B 73 18.806 12.988 -5.842 1.00 1.00 C +ATOM 2340 O2' U B 73 20.052 13.300 -6.476 1.00 1.00 O +ATOM 2341 C1' U B 73 18.783 11.547 -5.337 1.00 1.00 C +ATOM 2342 N1 U B 73 17.473 10.887 -5.497 1.00 1.00 N +ATOM 2343 C2 U B 73 17.285 10.104 -6.620 1.00 1.00 C +ATOM 2344 O2 U B 73 18.150 9.980 -7.484 1.00 1.00 O +ATOM 2345 N3 U B 73 16.059 9.468 -6.718 1.00 1.00 N +ATOM 2346 C4 U B 73 15.024 9.547 -5.802 1.00 1.00 C +ATOM 2347 O4 U B 73 13.974 8.933 -5.990 1.00 1.00 O +ATOM 2348 C5 U B 73 15.309 10.387 -4.661 1.00 1.00 C +ATOM 2349 C6 U B 73 16.501 11.020 -4.544 1.00 1.00 C +ATOM 2350 H5' U B 73 19.294 12.415 -1.440 1.00 1.00 H +ATOM 2351 H5'' U B 73 19.026 14.137 -1.775 1.00 1.00 H +ATOM 2352 H4' U B 73 20.362 13.122 -3.550 1.00 1.00 H +ATOM 2353 H3' U B 73 17.548 13.913 -4.343 1.00 1.00 H +ATOM 2354 H2' U B 73 17.973 13.153 -6.524 1.00 1.00 H +ATOM 2355 HO2' U B 73 20.739 12.829 -6.001 1.00 1.00 H +ATOM 2356 H1' U B 73 19.548 10.967 -5.854 1.00 1.00 H +ATOM 2357 H3 U B 73 15.907 8.892 -7.533 1.00 1.00 H +ATOM 2358 H5 U B 73 14.554 10.514 -3.885 1.00 1.00 H +ATOM 2359 H6 U B 73 16.688 11.649 -3.674 1.00 1.00 H +ATOM 2360 P C B 74 18.474 16.373 -5.147 1.00 1.00 P +ATOM 2361 OP1 C B 74 19.444 17.487 -5.248 1.00 1.00 O +ATOM 2362 OP2 C B 74 17.275 16.518 -4.291 1.00 1.00 O +ATOM 2363 O5' C B 74 17.987 15.996 -6.636 1.00 1.00 O +ATOM 2364 C5' C B 74 18.923 15.939 -7.716 1.00 1.00 C +ATOM 2365 C4' C B 74 18.289 15.377 -8.986 1.00 1.00 C +ATOM 2366 O4' C B 74 17.924 14.019 -8.782 1.00 1.00 O +ATOM 2367 C3' C B 74 17.020 16.079 -9.427 1.00 1.00 C +ATOM 2368 O3' C B 74 17.346 17.233 -10.209 1.00 1.00 O +ATOM 2369 C2' C B 74 16.368 15.017 -10.302 1.00 1.00 C +ATOM 2370 O2' C B 74 16.808 15.120 -11.662 1.00 1.00 O +ATOM 2371 C1' C B 74 16.831 13.702 -9.658 1.00 1.00 C +ATOM 2372 N1 C B 74 15.792 13.035 -8.844 1.00 1.00 N +ATOM 2373 C2 C B 74 15.089 11.997 -9.435 1.00 1.00 C +ATOM 2374 O2 C B 74 15.317 11.685 -10.602 1.00 1.00 O +ATOM 2375 N3 C B 74 14.149 11.349 -8.692 1.00 1.00 N +ATOM 2376 C4 C B 74 13.909 11.705 -7.422 1.00 1.00 C +ATOM 2377 N4 C B 74 12.982 11.049 -6.723 1.00 1.00 N +ATOM 2378 C5 C B 74 14.633 12.777 -6.809 1.00 1.00 C +ATOM 2379 C6 C B 74 15.561 13.410 -7.552 1.00 1.00 C +ATOM 2380 H5' C B 74 19.759 15.300 -7.428 1.00 1.00 H +ATOM 2381 H5'' C B 74 19.294 16.942 -7.920 1.00 1.00 H +ATOM 2382 H4' C B 74 19.017 15.418 -9.793 1.00 1.00 H +ATOM 2383 H3' C B 74 16.392 16.328 -8.570 1.00 1.00 H +ATOM 2384 H2' C B 74 15.286 15.096 -10.243 1.00 1.00 H +ATOM 2385 HO2' C B 74 17.205 14.280 -11.901 1.00 1.00 H +ATOM 2386 H1' C B 74 17.177 13.016 -10.432 1.00 1.00 H +ATOM 2387 H41 C B 74 12.468 10.290 -7.155 1.00 1.00 H +ATOM 2388 H42 C B 74 12.792 11.308 -5.766 1.00 1.00 H +ATOM 2389 H5 C B 74 14.442 13.068 -5.776 1.00 1.00 H +ATOM 2390 H6 C B 74 16.131 14.232 -7.118 1.00 1.00 H +ATOM 2391 P U B 75 16.685 18.665 -9.880 1.00 1.00 P +ATOM 2392 OP1 U B 75 17.590 19.715 -10.401 1.00 1.00 O +ATOM 2393 OP2 U B 75 16.298 18.678 -8.452 1.00 1.00 O +ATOM 2394 O5' U B 75 15.336 18.692 -10.767 1.00 1.00 O +ATOM 2395 C5' U B 75 15.379 18.355 -12.156 1.00 1.00 C +ATOM 2396 C4' U B 75 14.246 17.407 -12.558 1.00 1.00 C +ATOM 2397 O4' U B 75 14.267 16.234 -11.752 1.00 1.00 O +ATOM 2398 C3' U B 75 12.843 17.975 -12.414 1.00 1.00 C +ATOM 2399 O3' U B 75 12.476 18.677 -13.606 1.00 1.00 O +ATOM 2400 C2' U B 75 11.980 16.731 -12.270 1.00 1.00 C +ATOM 2401 O2' U B 75 11.406 16.343 -13.523 1.00 1.00 O +ATOM 2402 C1' U B 75 12.945 15.672 -11.742 1.00 1.00 C +ATOM 2403 N1 U B 75 12.629 15.211 -10.369 1.00 1.00 N +ATOM 2404 C2 U B 75 11.854 14.073 -10.248 1.00 1.00 C +ATOM 2405 O2 U B 75 11.429 13.465 -11.230 1.00 1.00 O +ATOM 2406 N3 U B 75 11.582 13.657 -8.958 1.00 1.00 N +ATOM 2407 C4 U B 75 12.011 14.270 -7.793 1.00 1.00 C +ATOM 2408 O4 U B 75 11.710 13.810 -6.694 1.00 1.00 O +ATOM 2409 C5 U B 75 12.815 15.452 -8.014 1.00 1.00 C +ATOM 2410 C6 U B 75 13.096 15.880 -9.270 1.00 1.00 C +ATOM 2411 H5' U B 75 16.335 17.876 -12.375 1.00 1.00 H +ATOM 2412 H5'' U B 75 15.298 19.269 -12.741 1.00 1.00 H +ATOM 2413 H4' U B 75 14.395 17.108 -13.594 1.00 1.00 H +ATOM 2414 H3' U B 75 12.766 18.612 -11.530 1.00 1.00 H +ATOM 2415 H2' U B 75 11.205 16.910 -11.532 1.00 1.00 H +ATOM 2416 HO2' U B 75 12.080 15.865 -14.012 1.00 1.00 H +ATOM 2417 H1' U B 75 12.926 14.817 -12.418 1.00 1.00 H +ATOM 2418 H3 U B 75 11.017 12.826 -8.855 1.00 1.00 H +ATOM 2419 H5 U B 75 13.201 16.007 -7.159 1.00 1.00 H +ATOM 2420 H6 U B 75 13.702 16.774 -9.407 1.00 1.00 H +ATOM 2421 P U B 76 11.256 19.734 -13.609 1.00 1.00 P +ATOM 2422 OP1 U B 76 11.256 20.431 -14.914 1.00 1.00 O +ATOM 2423 OP2 U B 76 11.323 20.517 -12.355 1.00 1.00 O +ATOM 2424 O5' U B 76 9.953 18.786 -13.542 1.00 1.00 O +ATOM 2425 C5' U B 76 9.653 17.887 -14.616 1.00 1.00 C +ATOM 2426 C4' U B 76 8.511 16.934 -14.261 1.00 1.00 C +ATOM 2427 O4' U B 76 8.889 16.106 -13.172 1.00 1.00 O +ATOM 2428 C3' U B 76 7.219 17.611 -13.838 1.00 1.00 C +ATOM 2429 O3' U B 76 6.409 17.862 -14.990 1.00 1.00 O +ATOM 2430 C2' U B 76 6.548 16.570 -12.948 1.00 1.00 C +ATOM 2431 O2' U B 76 5.592 15.793 -13.678 1.00 1.00 O +ATOM 2432 C1' U B 76 7.712 15.705 -12.455 1.00 1.00 C +ATOM 2433 N1 U B 76 7.997 15.847 -11.012 1.00 1.00 N +ATOM 2434 C2 U B 76 7.470 14.895 -10.160 1.00 1.00 C +ATOM 2435 O2 U B 76 6.779 13.963 -10.567 1.00 1.00 O +ATOM 2436 N3 U B 76 7.767 15.050 -8.819 1.00 1.00 N +ATOM 2437 C4 U B 76 8.534 16.060 -8.263 1.00 1.00 C +ATOM 2438 O4 U B 76 8.734 16.102 -7.051 1.00 1.00 O +ATOM 2439 C5 U B 76 9.044 17.009 -9.227 1.00 1.00 C +ATOM 2440 C6 U B 76 8.767 16.878 -10.547 1.00 1.00 C +ATOM 2441 H5' U B 76 10.544 17.301 -14.846 1.00 1.00 H +ATOM 2442 H5'' U B 76 9.372 18.465 -15.496 1.00 1.00 H +ATOM 2443 H4' U B 76 8.307 16.296 -15.119 1.00 1.00 H +ATOM 2444 H3' U B 76 7.422 18.528 -13.284 1.00 1.00 H +ATOM 2445 H2' U B 76 6.070 17.067 -12.098 1.00 1.00 H +ATOM 2446 HO2' U B 76 5.923 15.699 -14.574 1.00 1.00 H +ATOM 2447 H1' U B 76 7.497 14.661 -12.683 1.00 1.00 H +ATOM 2448 H3 U B 76 7.389 14.362 -8.184 1.00 1.00 H +ATOM 2449 H5 U B 76 9.660 17.842 -8.888 1.00 1.00 H +ATOM 2450 H6 U B 76 9.164 17.607 -11.252 1.00 1.00 H +ATOM 2451 P C B 77 5.109 18.803 -14.882 1.00 1.00 P +ATOM 2452 OP1 C B 77 4.372 18.723 -16.163 1.00 1.00 O +ATOM 2453 OP2 C B 77 5.532 20.118 -14.353 1.00 1.00 O +ATOM 2454 O5' C B 77 4.238 18.057 -13.751 1.00 1.00 O +ATOM 2455 C5' C B 77 3.852 18.745 -12.558 1.00 1.00 C +ATOM 2456 C4' C B 77 2.883 17.917 -11.718 1.00 1.00 C +ATOM 2457 O4' C B 77 3.604 16.960 -10.946 1.00 1.00 O +ATOM 2458 C3' C B 77 2.059 18.738 -10.740 1.00 1.00 C +ATOM 2459 O3' C B 77 0.808 19.080 -11.340 1.00 1.00 O +ATOM 2460 C2' C B 77 1.820 17.793 -9.569 1.00 1.00 C +ATOM 2461 O2' C B 77 0.531 17.178 -9.656 1.00 1.00 O +ATOM 2462 C1' C B 77 2.939 16.758 -9.690 1.00 1.00 C +ATOM 2463 N1 C B 77 3.955 16.850 -8.624 1.00 1.00 N +ATOM 2464 C2 C B 77 3.677 16.228 -7.417 1.00 1.00 C +ATOM 2465 O2 C B 77 2.611 15.637 -7.262 1.00 1.00 O +ATOM 2466 N3 C B 77 4.610 16.292 -6.427 1.00 1.00 N +ATOM 2467 C4 C B 77 5.767 16.942 -6.614 1.00 1.00 C +ATOM 2468 N4 C B 77 6.658 16.984 -5.625 1.00 1.00 N +ATOM 2469 C5 C B 77 6.057 17.588 -7.858 1.00 1.00 C +ATOM 2470 C6 C B 77 5.128 17.517 -8.831 1.00 1.00 C +ATOM 2471 H5' C B 77 3.372 19.685 -12.831 1.00 1.00 H +ATOM 2472 H5'' C B 77 4.742 18.959 -11.968 1.00 1.00 H +ATOM 2473 H4' C B 77 2.207 17.382 -12.384 1.00 1.00 H +ATOM 2474 H3' C B 77 2.605 19.626 -10.421 1.00 1.00 H +ATOM 2475 H2' C B 77 1.922 18.339 -8.628 1.00 1.00 H +ATOM 2476 HO2' C B 77 -0.042 17.783 -10.132 1.00 1.00 H +ATOM 2477 H1' C B 77 2.501 15.761 -9.675 1.00 1.00 H +ATOM 2478 H41 C B 77 6.459 16.532 -4.747 1.00 1.00 H +ATOM 2479 H42 C B 77 7.533 17.471 -5.755 1.00 1.00 H +ATOM 2480 H5 C B 77 6.996 18.118 -8.011 1.00 1.00 H +ATOM 2481 H6 C B 77 5.315 17.997 -9.792 1.00 1.00 H +ATOM 2482 P C B 78 -0.183 20.123 -10.620 1.00 1.00 P +ATOM 2483 OP1 C B 78 -1.438 20.185 -11.402 1.00 1.00 O +ATOM 2484 OP2 C B 78 0.574 21.363 -10.337 1.00 1.00 O +ATOM 2485 O5' C B 78 -0.498 19.394 -9.221 1.00 1.00 O +ATOM 2486 C5' C B 78 -0.582 20.152 -8.013 1.00 1.00 C +ATOM 2487 C4' C B 78 -1.190 19.334 -6.878 1.00 1.00 C +ATOM 2488 O4' C B 78 -0.279 18.315 -6.470 1.00 1.00 O +ATOM 2489 C3' C B 78 -1.521 20.152 -5.643 1.00 1.00 C +ATOM 2490 O3' C B 78 -2.883 20.586 -5.713 1.00 1.00 O +ATOM 2491 C2' C B 78 -1.342 19.174 -4.494 1.00 1.00 C +ATOM 2492 O2' C B 78 -2.586 18.567 -4.130 1.00 1.00 O +ATOM 2493 C1' C B 78 -0.358 18.141 -5.048 1.00 1.00 C +ATOM 2494 N1 C B 78 1.010 18.271 -4.515 1.00 1.00 N +ATOM 2495 C2 C B 78 1.271 17.702 -3.278 1.00 1.00 C +ATOM 2496 O2 C B 78 0.376 17.123 -2.667 1.00 1.00 O +ATOM 2497 N3 C B 78 2.531 17.807 -2.774 1.00 1.00 N +ATOM 2498 C4 C B 78 3.495 18.443 -3.454 1.00 1.00 C +ATOM 2499 N4 C B 78 4.718 18.527 -2.931 1.00 1.00 N +ATOM 2500 C5 C B 78 3.228 19.031 -4.731 1.00 1.00 C +ATOM 2501 C6 C B 78 1.979 18.922 -5.221 1.00 1.00 C +ATOM 2502 H5' C B 78 -1.200 21.032 -8.188 1.00 1.00 H +ATOM 2503 H5'' C B 78 0.419 20.472 -7.724 1.00 1.00 H +ATOM 2504 H4' C B 78 -2.100 18.857 -7.237 1.00 1.00 H +ATOM 2505 H3' C B 78 -0.839 20.999 -5.544 1.00 1.00 H +ATOM 2506 H2' C B 78 -0.897 19.685 -3.637 1.00 1.00 H +ATOM 2507 HO2' C B 78 -3.108 19.234 -3.681 1.00 1.00 H +ATOM 2508 H1' C B 78 -0.730 17.141 -4.830 1.00 1.00 H +ATOM 2509 H41 C B 78 4.911 18.114 -2.030 1.00 1.00 H +ATOM 2510 H42 C B 78 5.450 19.005 -3.436 1.00 1.00 H +ATOM 2511 H5 C B 78 4.009 19.549 -5.287 1.00 1.00 H +ATOM 2512 H6 C B 78 1.739 19.358 -6.191 1.00 1.00 H +ATOM 2513 P U B 79 -3.350 21.937 -4.976 1.00 1.00 P +ATOM 2514 OP1 U B 79 -4.723 22.258 -5.424 1.00 1.00 O +ATOM 2515 OP2 U B 79 -2.272 22.941 -5.120 1.00 1.00 O +ATOM 2516 O5' U B 79 -3.415 21.487 -3.433 1.00 1.00 O +ATOM 2517 C5' U B 79 -3.042 22.395 -2.396 1.00 1.00 C +ATOM 2518 C4' U B 79 -2.978 21.696 -1.043 1.00 1.00 C +ATOM 2519 O4' U B 79 -1.908 20.749 -1.042 1.00 1.00 O +ATOM 2520 C3' U B 79 -2.738 22.635 0.132 1.00 1.00 C +ATOM 2521 O3' U B 79 -3.993 23.016 0.714 1.00 1.00 O +ATOM 2522 C2' U B 79 -1.949 21.794 1.123 1.00 1.00 C +ATOM 2523 O2' U B 79 -2.793 21.290 2.163 1.00 1.00 O +ATOM 2524 C1' U B 79 -1.368 20.661 0.280 1.00 1.00 C +ATOM 2525 N1 U B 79 0.104 20.687 0.182 1.00 1.00 N +ATOM 2526 C2 U B 79 0.804 20.562 1.367 1.00 1.00 C +ATOM 2527 O2 U B 79 0.237 20.463 2.453 1.00 1.00 O +ATOM 2528 N3 U B 79 2.182 20.557 1.260 1.00 1.00 N +ATOM 2529 C4 U B 79 2.912 20.666 0.088 1.00 1.00 C +ATOM 2530 O4 U B 79 4.141 20.647 0.110 1.00 1.00 O +ATOM 2531 C5 U B 79 2.099 20.793 -1.101 1.00 1.00 C +ATOM 2532 C6 U B 79 0.747 20.800 -1.021 1.00 1.00 C +ATOM 2533 H5' U B 79 -3.773 23.201 -2.347 1.00 1.00 H +ATOM 2534 H5'' U B 79 -2.062 22.815 -2.627 1.00 1.00 H +ATOM 2535 H4' U B 79 -3.911 21.159 -0.882 1.00 1.00 H +ATOM 2536 H3' U B 79 -2.165 23.509 -0.181 1.00 1.00 H +ATOM 2537 H2' U B 79 -1.139 22.389 1.545 1.00 1.00 H +ATOM 2538 HO2' U B 79 -2.303 21.357 2.983 1.00 1.00 H +ATOM 2539 H1' U B 79 -1.669 19.710 0.719 1.00 1.00 H +ATOM 2540 H3 U B 79 2.708 20.466 2.118 1.00 1.00 H +ATOM 2541 H5 U B 79 2.581 20.885 -2.074 1.00 1.00 H +ATOM 2542 H6 U B 79 0.158 20.899 -1.933 1.00 1.00 H +ATOM 2543 P A B 80 -4.122 24.371 1.582 1.00 1.00 P +ATOM 2544 OP1 A B 80 -5.552 24.585 1.898 1.00 1.00 O +ATOM 2545 OP2 A B 80 -3.352 25.433 0.896 1.00 1.00 O +ATOM 2546 O5' A B 80 -3.353 23.998 2.950 1.00 1.00 O +ATOM 2547 C5' A B 80 -3.860 22.975 3.816 1.00 1.00 C +ATOM 2548 C4' A B 80 -2.929 22.727 5.003 1.00 1.00 C +ATOM 2549 O4' A B 80 -1.607 22.475 4.519 1.00 1.00 O +ATOM 2550 C3' A B 80 -2.844 23.892 5.988 1.00 1.00 C +ATOM 2551 O3' A B 80 -2.769 23.377 7.322 1.00 1.00 O +ATOM 2552 C2' A B 80 -1.537 24.588 5.638 1.00 1.00 C +ATOM 2553 O2' A B 80 -0.889 25.103 6.805 1.00 1.00 O +ATOM 2554 C1' A B 80 -0.710 23.487 4.989 1.00 1.00 C +ATOM 2555 N9 A B 80 0.093 23.942 3.838 1.00 1.00 N +ATOM 2556 C8 A B 80 -0.328 24.536 2.676 1.00 1.00 C +ATOM 2557 N7 A B 80 0.640 24.826 1.851 1.00 1.00 N +ATOM 2558 C5 A B 80 1.784 24.395 2.514 1.00 1.00 C +ATOM 2559 C6 A B 80 3.146 24.417 2.171 1.00 1.00 C +ATOM 2560 N6 A B 80 3.600 24.913 1.019 1.00 1.00 N +ATOM 2561 N1 A B 80 4.014 23.907 3.060 1.00 1.00 N +ATOM 2562 C2 A B 80 3.556 23.412 4.204 1.00 1.00 C +ATOM 2563 N3 A B 80 2.307 23.334 4.641 1.00 1.00 N +ATOM 2564 C4 A B 80 1.460 23.854 3.726 1.00 1.00 C +ATOM 2565 H5' A B 80 -3.969 22.052 3.249 1.00 1.00 H +ATOM 2566 H5'' A B 80 -4.837 23.280 4.188 1.00 1.00 H +ATOM 2567 H4' A B 80 -3.273 21.844 5.536 1.00 1.00 H +ATOM 2568 H3' A B 80 -3.692 24.569 5.869 1.00 1.00 H +ATOM 2569 H2' A B 80 -1.724 25.387 4.915 1.00 1.00 H +ATOM 2570 HO2' A B 80 -1.571 25.472 7.372 1.00 1.00 H +ATOM 2571 H1' A B 80 -0.043 23.055 5.735 1.00 1.00 H +ATOM 2572 H8 A B 80 -1.376 24.746 2.460 1.00 1.00 H +ATOM 2573 H61 A B 80 4.590 24.905 0.820 1.00 1.00 H +ATOM 2574 H62 A B 80 2.953 25.298 0.346 1.00 1.00 H +ATOM 2575 H2 A B 80 4.314 23.015 4.880 1.00 1.00 H +ATOM 2576 P A B 81 -3.138 24.299 8.592 1.00 1.00 P +ATOM 2577 OP1 A B 81 -4.609 24.299 8.751 1.00 1.00 O +ATOM 2578 OP2 A B 81 -2.411 25.581 8.466 1.00 1.00 O +ATOM 2579 O5' A B 81 -2.500 23.475 9.822 1.00 1.00 O +ATOM 2580 C5' A B 81 -3.338 22.710 10.694 1.00 1.00 C +ATOM 2581 C4' A B 81 -2.537 21.677 11.486 1.00 1.00 C +ATOM 2582 O4' A B 81 -2.003 20.702 10.586 1.00 1.00 O +ATOM 2583 C3' A B 81 -1.369 22.267 12.269 1.00 1.00 C +ATOM 2584 O3' A B 81 -1.742 22.419 13.642 1.00 1.00 O +ATOM 2585 C2' A B 81 -0.275 21.217 12.158 1.00 1.00 C +ATOM 2586 O2' A B 81 -0.285 20.334 13.285 1.00 1.00 O +ATOM 2587 C1' A B 81 -0.618 20.477 10.872 1.00 1.00 C +ATOM 2588 N9 A B 81 0.159 20.923 9.702 1.00 1.00 N +ATOM 2589 C8 A B 81 -0.250 21.668 8.627 1.00 1.00 C +ATOM 2590 N7 A B 81 0.691 21.893 7.751 1.00 1.00 N +ATOM 2591 C5 A B 81 1.802 21.249 8.285 1.00 1.00 C +ATOM 2592 C6 A B 81 3.126 21.111 7.835 1.00 1.00 C +ATOM 2593 N6 A B 81 3.568 21.640 6.693 1.00 1.00 N +ATOM 2594 N1 A B 81 3.970 20.407 8.609 1.00 1.00 N +ATOM 2595 C2 A B 81 3.524 19.884 9.744 1.00 1.00 C +ATOM 2596 N3 A B 81 2.311 19.944 10.272 1.00 1.00 N +ATOM 2597 C4 A B 81 1.488 20.655 9.474 1.00 1.00 C +ATOM 2598 H5' A B 81 -4.092 22.194 10.100 1.00 1.00 H +ATOM 2599 H5'' A B 81 -3.833 23.385 11.391 1.00 1.00 H +ATOM 2600 H4' A B 81 -3.206 21.174 12.180 1.00 1.00 H +ATOM 2601 H3' A B 81 -1.045 23.215 11.837 1.00 1.00 H +ATOM 2602 H2' A B 81 0.698 21.703 12.057 1.00 1.00 H +ATOM 2603 HO2' A B 81 -0.870 19.605 13.070 1.00 1.00 H +ATOM 2604 H1' A B 81 -0.454 19.410 11.020 1.00 1.00 H +ATOM 2605 H8 A B 81 -1.270 22.039 8.513 1.00 1.00 H +ATOM 2606 H61 A B 81 4.530 21.511 6.416 1.00 1.00 H +ATOM 2607 H62 A B 81 2.939 22.170 6.106 1.00 1.00 H +ATOM 2608 H2 A B 81 4.260 19.325 10.323 1.00 1.00 H +ATOM 2609 P G B 82 -0.875 23.348 14.632 1.00 1.00 P +ATOM 2610 OP1 G B 82 -1.732 23.729 15.777 1.00 1.00 O +ATOM 2611 OP2 G B 82 -0.218 24.398 13.822 1.00 1.00 O +ATOM 2612 O5' G B 82 0.262 22.339 15.167 1.00 1.00 O +ATOM 2613 C5' G B 82 1.427 22.844 15.826 1.00 1.00 C +ATOM 2614 C4' G B 82 2.644 21.946 15.594 1.00 1.00 C +ATOM 2615 O4' G B 82 2.610 21.432 14.259 1.00 1.00 O +ATOM 2616 C3' G B 82 3.988 22.653 15.785 1.00 1.00 C +ATOM 2617 O3' G B 82 4.557 22.277 17.043 1.00 1.00 O +ATOM 2618 C2' G B 82 4.853 22.122 14.652 1.00 1.00 C +ATOM 2619 O2' G B 82 5.621 20.988 15.067 1.00 1.00 O +ATOM 2620 C1' G B 82 3.834 21.742 13.589 1.00 1.00 C +ATOM 2621 N9 G B 82 3.546 22.816 12.625 1.00 1.00 N +ATOM 2622 C8 G B 82 2.424 23.598 12.526 1.00 1.00 C +ATOM 2623 N7 G B 82 2.469 24.466 11.555 1.00 1.00 N +ATOM 2624 C5 G B 82 3.710 24.246 10.963 1.00 1.00 C +ATOM 2625 C6 G B 82 4.319 24.894 9.854 1.00 1.00 C +ATOM 2626 O6 G B 82 3.872 25.807 9.163 1.00 1.00 O +ATOM 2627 N1 G B 82 5.576 24.368 9.584 1.00 1.00 N +ATOM 2628 C2 G B 82 6.174 23.347 10.291 1.00 1.00 C +ATOM 2629 N2 G B 82 7.387 22.977 9.880 1.00 1.00 N +ATOM 2630 N3 G B 82 5.604 22.737 11.335 1.00 1.00 N +ATOM 2631 C4 G B 82 4.377 23.237 11.613 1.00 1.00 C +ATOM 2632 H5' G B 82 1.231 22.905 16.896 1.00 1.00 H +ATOM 2633 H5'' G B 82 1.641 23.844 15.449 1.00 1.00 H +ATOM 2634 H4' G B 82 2.593 21.107 16.285 1.00 1.00 H +ATOM 2635 H3' G B 82 3.876 23.735 15.710 1.00 1.00 H +ATOM 2636 H2' G B 82 5.503 22.914 14.275 1.00 1.00 H +ATOM 2637 HO2' G B 82 5.917 20.537 14.272 1.00 1.00 H +ATOM 2638 H1' G B 82 4.184 20.862 13.050 1.00 1.00 H +ATOM 2639 H8 G B 82 1.571 23.501 13.197 1.00 1.00 H +ATOM 2640 H1 G B 82 6.071 24.779 8.807 1.00 1.00 H +ATOM 2641 H21 G B 82 7.816 23.440 9.091 1.00 1.00 H +ATOM 2642 H22 G B 82 7.876 22.234 10.358 1.00 1.00 H +ATOM 2643 P U B 83 5.135 23.400 18.044 1.00 1.00 P +ATOM 2644 OP1 U B 83 5.615 22.722 19.270 1.00 1.00 O +ATOM 2645 OP2 U B 83 4.135 24.486 18.146 1.00 1.00 O +ATOM 2646 O5' U B 83 6.416 23.970 17.249 1.00 1.00 O +ATOM 2647 C5' U B 83 7.685 23.318 17.345 1.00 1.00 C +ATOM 2648 C4' U B 83 8.761 24.068 16.566 1.00 1.00 C +ATOM 2649 O4' U B 83 8.493 23.985 15.166 1.00 1.00 O +ATOM 2650 C3' U B 83 8.859 25.545 16.913 1.00 1.00 C +ATOM 2651 O3' U B 83 9.831 25.731 17.950 1.00 1.00 O +ATOM 2652 C2' U B 83 9.341 26.177 15.619 1.00 1.00 C +ATOM 2653 O2' U B 83 10.770 26.236 15.565 1.00 1.00 O +ATOM 2654 C1' U B 83 8.778 25.247 14.546 1.00 1.00 C +ATOM 2655 N1 U B 83 7.523 25.729 13.935 1.00 1.00 N +ATOM 2656 C2 U B 83 7.622 26.524 12.808 1.00 1.00 C +ATOM 2657 O2 U B 83 8.707 26.841 12.324 1.00 1.00 O +ATOM 2658 N3 U B 83 6.426 26.945 12.256 1.00 1.00 N +ATOM 2659 C4 U B 83 5.158 26.645 12.726 1.00 1.00 C +ATOM 2660 O4 U B 83 4.159 27.075 12.153 1.00 1.00 O +ATOM 2661 C5 U B 83 5.152 25.809 13.906 1.00 1.00 C +ATOM 2662 C6 U B 83 6.311 25.384 14.464 1.00 1.00 C +ATOM 2663 H5' U B 83 7.598 22.307 16.947 1.00 1.00 H +ATOM 2664 H5'' U B 83 7.978 23.265 18.394 1.00 1.00 H +ATOM 2665 H4' U B 83 9.725 23.598 16.758 1.00 1.00 H +ATOM 2666 H3' U B 83 7.885 25.942 17.202 1.00 1.00 H +ATOM 2667 H2' U B 83 8.910 27.173 15.507 1.00 1.00 H +ATOM 2668 HO2' U B 83 11.041 27.033 16.029 1.00 1.00 H +ATOM 2669 H1' U B 83 9.526 25.102 13.765 1.00 1.00 H +ATOM 2670 H3 U B 83 6.483 27.527 11.432 1.00 1.00 H +ATOM 2671 H5 U B 83 4.201 25.519 14.353 1.00 1.00 H +ATOM 2672 H6 U B 83 6.276 24.755 15.353 1.00 1.00 H +ATOM 2673 P C B 84 9.610 26.835 19.104 1.00 1.00 P +ATOM 2674 OP1 C B 84 10.669 26.656 20.122 1.00 1.00 O +ATOM 2675 OP2 C B 84 8.186 26.802 19.509 1.00 1.00 O +ATOM 2676 O5' C B 84 9.882 28.225 18.335 1.00 1.00 O +ATOM 2677 C5' C B 84 11.219 28.688 18.116 1.00 1.00 C +ATOM 2678 C4' C B 84 11.250 29.893 17.183 1.00 1.00 C +ATOM 2679 O4' C B 84 10.601 29.568 15.957 1.00 1.00 O +ATOM 2680 C3' C B 84 10.553 31.126 17.732 1.00 1.00 C +ATOM 2681 O3' C B 84 11.495 31.929 18.458 1.00 1.00 O +ATOM 2682 C2' C B 84 10.097 31.851 16.478 1.00 1.00 C +ATOM 2683 O2' C B 84 11.083 32.783 16.021 1.00 1.00 O +ATOM 2684 C1' C B 84 9.887 30.717 15.475 1.00 1.00 C +ATOM 2685 N1 C B 84 8.473 30.323 15.316 1.00 1.00 N +ATOM 2686 C2 C B 84 7.761 30.873 14.261 1.00 1.00 C +ATOM 2687 O2 C B 84 8.305 31.677 13.506 1.00 1.00 O +ATOM 2688 N3 C B 84 6.462 30.501 14.094 1.00 1.00 N +ATOM 2689 C4 C B 84 5.885 29.626 14.929 1.00 1.00 C +ATOM 2690 N4 C B 84 4.611 29.282 14.737 1.00 1.00 N +ATOM 2691 C5 C B 84 6.615 29.055 16.019 1.00 1.00 C +ATOM 2692 C6 C B 84 7.900 29.430 16.175 1.00 1.00 C +ATOM 2693 H5' C B 84 11.806 27.883 17.676 1.00 1.00 H +ATOM 2694 H5'' C B 84 11.659 28.968 19.072 1.00 1.00 H +ATOM 2695 H4' C B 84 12.286 30.142 16.965 1.00 1.00 H +ATOM 2696 H3' C B 84 9.702 30.846 18.354 1.00 1.00 H +ATOM 2697 H2' C B 84 9.149 32.351 16.664 1.00 1.00 H +ATOM 2698 HO2' C B 84 11.567 32.361 15.308 1.00 1.00 H +ATOM 2699 H1' C B 84 10.293 31.014 14.506 1.00 1.00 H +ATOM 2700 H41 C B 84 4.092 29.680 13.971 1.00 1.00 H +ATOM 2701 H42 C B 84 4.167 28.624 15.361 1.00 1.00 H +ATOM 2702 H5 C B 84 6.148 28.343 16.699 1.00 1.00 H +ATOM 2703 H6 C B 84 8.487 29.016 16.995 1.00 1.00 H +ATOM 2704 P C B 85 11.013 32.877 19.671 1.00 1.00 P +ATOM 2705 OP1 C B 85 12.220 33.408 20.344 1.00 1.00 O +ATOM 2706 OP2 C B 85 9.994 32.146 20.456 1.00 1.00 O +ATOM 2707 O5' C B 85 10.285 34.103 18.918 1.00 1.00 O +ATOM 2708 C5' C B 85 11.057 35.095 18.234 1.00 1.00 C +ATOM 2709 C4' C B 85 10.179 36.005 17.375 1.00 1.00 C +ATOM 2710 O4' C B 85 9.377 35.217 16.499 1.00 1.00 O +ATOM 2711 C3' C B 85 9.210 36.879 18.156 1.00 1.00 C +ATOM 2712 O3' C B 85 9.828 38.125 18.499 1.00 1.00 O +ATOM 2713 C2' C B 85 8.083 37.124 17.167 1.00 1.00 C +ATOM 2714 O2' C B 85 8.276 38.349 16.450 1.00 1.00 O +ATOM 2715 C1' C B 85 8.151 35.916 16.234 1.00 1.00 C +ATOM 2716 N1 C B 85 7.038 34.964 16.422 1.00 1.00 N +ATOM 2717 C2 C B 85 5.901 35.151 15.652 1.00 1.00 C +ATOM 2718 O2 C B 85 5.844 36.085 14.855 1.00 1.00 O +ATOM 2719 N3 C B 85 4.866 34.279 15.808 1.00 1.00 N +ATOM 2720 C4 C B 85 4.944 33.267 16.682 1.00 1.00 C +ATOM 2721 N4 C B 85 3.913 32.432 16.812 1.00 1.00 N +ATOM 2722 C5 C B 85 6.117 33.072 17.478 1.00 1.00 C +ATOM 2723 C6 C B 85 7.135 33.938 17.316 1.00 1.00 C +ATOM 2724 H5' C B 85 11.788 34.600 17.594 1.00 1.00 H +ATOM 2725 H5'' C B 85 11.582 35.703 18.969 1.00 1.00 H +ATOM 2726 H4' C B 85 10.820 36.642 16.769 1.00 1.00 H +ATOM 2727 H3' C B 85 8.844 36.357 19.043 1.00 1.00 H +ATOM 2728 H2' C B 85 7.130 37.132 17.690 1.00 1.00 H +ATOM 2729 HO2' C B 85 8.945 38.187 15.782 1.00 1.00 H +ATOM 2730 H1' C B 85 8.155 36.263 15.200 1.00 1.00 H +ATOM 2731 H41 C B 85 3.083 32.565 16.251 1.00 1.00 H +ATOM 2732 H42 C B 85 3.962 31.665 17.467 1.00 1.00 H +ATOM 2733 H5 C B 85 6.185 32.250 18.191 1.00 1.00 H +ATOM 2734 H6 C B 85 8.045 33.819 17.905 1.00 1.00 H +ATOM 2735 P U B 86 9.204 39.046 19.665 1.00 1.00 P +ATOM 2736 OP1 U B 86 9.989 40.299 19.733 1.00 1.00 O +ATOM 2737 OP2 U B 86 9.040 38.212 20.876 1.00 1.00 O +ATOM 2738 O5' U B 86 7.737 39.402 19.091 1.00 1.00 O +ATOM 2739 C5' U B 86 7.592 40.283 17.973 1.00 1.00 C +ATOM 2740 C4' U B 86 6.132 40.430 17.538 1.00 1.00 C +ATOM 2741 O4' U B 86 5.579 39.155 17.242 1.00 1.00 O +ATOM 2742 C3' U B 86 5.220 41.062 18.583 1.00 1.00 C +ATOM 2743 O3' U B 86 5.095 42.473 18.374 1.00 1.00 O +ATOM 2744 C2' U B 86 3.876 40.352 18.383 1.00 1.00 C +ATOM 2745 O2' U B 86 2.874 41.260 17.914 1.00 1.00 O +ATOM 2746 C1' U B 86 4.161 39.269 17.352 1.00 1.00 C +ATOM 2747 N1 U B 86 3.616 37.946 17.724 1.00 1.00 N +ATOM 2748 C2 U B 86 2.377 37.602 17.216 1.00 1.00 C +ATOM 2749 O2 U B 86 1.741 38.354 16.483 1.00 1.00 O +ATOM 2750 N3 U B 86 1.893 36.360 17.585 1.00 1.00 N +ATOM 2751 C4 U B 86 2.532 35.445 18.406 1.00 1.00 C +ATOM 2752 O4 U B 86 2.006 34.365 18.667 1.00 1.00 O +ATOM 2753 C5 U B 86 3.820 35.887 18.890 1.00 1.00 C +ATOM 2754 C6 U B 86 4.315 37.101 18.543 1.00 1.00 C +ATOM 2755 H5' U B 86 8.173 39.894 17.138 1.00 1.00 H +ATOM 2756 H5'' U B 86 7.978 41.265 18.246 1.00 1.00 H +ATOM 2757 H4' U B 86 6.097 41.035 16.634 1.00 1.00 H +ATOM 2758 H3' U B 86 5.605 40.855 19.584 1.00 1.00 H +ATOM 2759 HO3' U B 86 4.998 42.614 17.429 1.00 1.00 H +ATOM 2760 H2' U B 86 3.559 39.884 19.317 1.00 1.00 H +ATOM 2761 HO2' U B 86 2.247 41.388 18.628 1.00 1.00 H +ATOM 2762 H1' U B 86 3.752 39.574 16.388 1.00 1.00 H +ATOM 2763 H3 U B 86 0.989 36.095 17.222 1.00 1.00 H +ATOM 2764 H5 U B 86 4.399 35.238 19.546 1.00 1.00 H +ATOM 2765 H6 U B 86 5.288 37.410 18.923 1.00 1.00 H +TER 2766 U B 86 +ENDMDL +MODEL 6 +ATOM 1 O5' G A 1 2.881 -42.926 6.954 1.00 1.00 O +ATOM 2 C5' G A 1 3.433 -43.878 6.044 1.00 1.00 C +ATOM 3 C4' G A 1 2.389 -44.355 5.034 1.00 1.00 C +ATOM 4 O4' G A 1 1.368 -45.096 5.711 1.00 1.00 O +ATOM 5 C3' G A 1 1.705 -43.225 4.270 1.00 1.00 C +ATOM 6 O3' G A 1 2.292 -43.098 2.971 1.00 1.00 O +ATOM 7 C2' G A 1 0.266 -43.687 4.137 1.00 1.00 C +ATOM 8 O2' G A 1 0.059 -44.404 2.915 1.00 1.00 O +ATOM 9 C1' G A 1 0.080 -44.587 5.348 1.00 1.00 C +ATOM 10 N9 G A 1 -0.469 -43.894 6.526 1.00 1.00 N +ATOM 11 C8 G A 1 0.156 -43.585 7.705 1.00 1.00 C +ATOM 12 N7 G A 1 -0.604 -42.958 8.559 1.00 1.00 N +ATOM 13 C5 G A 1 -1.824 -42.843 7.899 1.00 1.00 C +ATOM 14 C6 G A 1 -3.041 -42.249 8.330 1.00 1.00 C +ATOM 15 O6 G A 1 -3.283 -41.698 9.403 1.00 1.00 O +ATOM 16 N1 G A 1 -4.029 -42.347 7.359 1.00 1.00 N +ATOM 17 C2 G A 1 -3.869 -42.941 6.125 1.00 1.00 C +ATOM 18 N2 G A 1 -4.935 -42.939 5.325 1.00 1.00 N +ATOM 19 N3 G A 1 -2.725 -43.500 5.717 1.00 1.00 N +ATOM 20 C4 G A 1 -1.750 -43.414 6.651 1.00 1.00 C +ATOM 21 H5' G A 1 3.811 -44.733 6.612 1.00 1.00 H +ATOM 22 H5'' G A 1 4.259 -43.421 5.504 1.00 1.00 H +ATOM 23 H4' G A 1 2.873 -45.017 4.318 1.00 1.00 H +ATOM 24 H3' G A 1 1.764 -42.287 4.825 1.00 1.00 H +ATOM 25 H2' G A 1 -0.409 -42.830 4.203 1.00 1.00 H +ATOM 26 HO2' G A 1 -0.160 -45.310 3.148 1.00 1.00 H +ATOM 27 H1' G A 1 -0.576 -45.417 5.084 1.00 1.00 H +ATOM 28 H8 G A 1 1.196 -43.839 7.912 1.00 1.00 H +ATOM 29 H1 G A 1 -4.925 -41.945 7.595 1.00 1.00 H +ATOM 30 H21 G A 1 -5.798 -42.516 5.635 1.00 1.00 H +ATOM 31 H22 G A 1 -4.880 -43.359 4.409 1.00 1.00 H +ATOM 32 HO5' G A 1 2.028 -42.657 6.606 1.00 1.00 H +ATOM 33 P G A 2 2.310 -41.676 2.215 1.00 1.00 P +ATOM 34 OP1 G A 2 2.803 -41.892 0.837 1.00 1.00 O +ATOM 35 OP2 G A 2 2.986 -40.696 3.095 1.00 1.00 O +ATOM 36 O5' G A 2 0.749 -41.289 2.136 1.00 1.00 O +ATOM 37 C5' G A 2 -0.158 -42.047 1.329 1.00 1.00 C +ATOM 38 C4' G A 2 -1.576 -41.488 1.410 1.00 1.00 C +ATOM 39 O4' G A 2 -2.096 -41.643 2.724 1.00 1.00 O +ATOM 40 C3' G A 2 -1.683 -40.008 1.081 1.00 1.00 C +ATOM 41 O3' G A 2 -1.889 -39.850 -0.329 1.00 1.00 O +ATOM 42 C2' G A 2 -2.917 -39.560 1.853 1.00 1.00 C +ATOM 43 O2' G A 2 -4.083 -39.546 1.020 1.00 1.00 O +ATOM 44 C1' G A 2 -3.040 -40.595 2.975 1.00 1.00 C +ATOM 45 N9 G A 2 -2.768 -40.054 4.313 1.00 1.00 N +ATOM 46 C8 G A 2 -1.589 -40.014 5.014 1.00 1.00 C +ATOM 47 N7 G A 2 -1.694 -39.470 6.194 1.00 1.00 N +ATOM 48 C5 G A 2 -3.039 -39.123 6.287 1.00 1.00 C +ATOM 49 C6 G A 2 -3.750 -38.495 7.347 1.00 1.00 C +ATOM 50 O6 G A 2 -3.319 -38.116 8.435 1.00 1.00 O +ATOM 51 N1 G A 2 -5.092 -38.327 7.032 1.00 1.00 N +ATOM 52 C2 G A 2 -5.681 -38.714 5.848 1.00 1.00 C +ATOM 53 N2 G A 2 -6.985 -38.469 5.727 1.00 1.00 N +ATOM 54 N3 G A 2 -5.015 -39.305 4.850 1.00 1.00 N +ATOM 55 C4 G A 2 -3.704 -39.477 5.139 1.00 1.00 C +ATOM 56 H5' G A 2 -0.164 -43.081 1.673 1.00 1.00 H +ATOM 57 H5'' G A 2 0.178 -42.020 0.292 1.00 1.00 H +ATOM 58 H4' G A 2 -2.210 -42.044 0.723 1.00 1.00 H +ATOM 59 H3' G A 2 -0.795 -39.469 1.417 1.00 1.00 H +ATOM 60 H2' G A 2 -2.741 -38.574 2.285 1.00 1.00 H +ATOM 61 HO2' G A 2 -4.138 -40.401 0.590 1.00 1.00 H +ATOM 62 H1' G A 2 -4.047 -41.014 2.967 1.00 1.00 H +ATOM 63 H8 G A 2 -0.650 -40.401 4.618 1.00 1.00 H +ATOM 64 H1 G A 2 -5.662 -37.886 7.740 1.00 1.00 H +ATOM 65 H21 G A 2 -7.486 -38.023 6.482 1.00 1.00 H +ATOM 66 H22 G A 2 -7.471 -38.730 4.882 1.00 1.00 H +ATOM 67 P G A 3 -1.499 -38.479 -1.081 1.00 1.00 P +ATOM 68 OP1 G A 3 -1.469 -38.745 -2.537 1.00 1.00 O +ATOM 69 OP2 G A 3 -0.312 -37.901 -0.414 1.00 1.00 O +ATOM 70 O5' G A 3 -2.764 -37.533 -0.768 1.00 1.00 O +ATOM 71 C5' G A 3 -4.074 -37.903 -1.209 1.00 1.00 C +ATOM 72 C4' G A 3 -5.151 -37.055 -0.536 1.00 1.00 C +ATOM 73 O4' G A 3 -4.974 -37.086 0.877 1.00 1.00 O +ATOM 74 C3' G A 3 -5.139 -35.588 -0.939 1.00 1.00 C +ATOM 75 O3' G A 3 -6.005 -35.382 -2.063 1.00 1.00 O +ATOM 76 C2' G A 3 -5.700 -34.877 0.283 1.00 1.00 C +ATOM 77 O2' G A 3 -7.102 -34.628 0.144 1.00 1.00 O +ATOM 78 C1' G A 3 -5.418 -35.843 1.434 1.00 1.00 C +ATOM 79 N9 G A 3 -4.379 -35.366 2.363 1.00 1.00 N +ATOM 80 C8 G A 3 -3.049 -35.698 2.416 1.00 1.00 C +ATOM 81 N7 G A 3 -2.396 -35.111 3.379 1.00 1.00 N +ATOM 82 C5 G A 3 -3.359 -34.331 4.011 1.00 1.00 C +ATOM 83 C6 G A 3 -3.238 -33.465 5.133 1.00 1.00 C +ATOM 84 O6 G A 3 -2.236 -33.216 5.800 1.00 1.00 O +ATOM 85 N1 G A 3 -4.451 -32.867 5.448 1.00 1.00 N +ATOM 86 C2 G A 3 -5.634 -33.073 4.771 1.00 1.00 C +ATOM 87 N2 G A 3 -6.695 -32.407 5.222 1.00 1.00 N +ATOM 88 N3 G A 3 -5.751 -33.888 3.718 1.00 1.00 N +ATOM 89 C4 G A 3 -4.577 -34.481 3.395 1.00 1.00 C +ATOM 90 H5' G A 3 -4.247 -38.953 -0.970 1.00 1.00 H +ATOM 91 H5'' G A 3 -4.137 -37.769 -2.289 1.00 1.00 H +ATOM 92 H4' G A 3 -6.127 -37.477 -0.768 1.00 1.00 H +ATOM 93 H3' G A 3 -4.123 -35.252 -1.152 1.00 1.00 H +ATOM 94 H2' G A 3 -5.157 -33.944 0.447 1.00 1.00 H +ATOM 95 HO2' G A 3 -7.277 -33.763 0.523 1.00 1.00 H +ATOM 96 H1' G A 3 -6.339 -36.014 1.994 1.00 1.00 H +ATOM 97 H8 G A 3 -2.581 -36.390 1.716 1.00 1.00 H +ATOM 98 H1 G A 3 -4.443 -32.237 6.236 1.00 1.00 H +ATOM 99 H21 G A 3 -6.604 -31.792 6.017 1.00 1.00 H +ATOM 100 H22 G A 3 -7.591 -32.517 4.767 1.00 1.00 H +ATOM 101 P A A 4 -5.743 -34.171 -3.097 1.00 1.00 P +ATOM 102 OP1 A A 4 -6.420 -34.497 -4.372 1.00 1.00 O +ATOM 103 OP2 A A 4 -4.296 -33.861 -3.092 1.00 1.00 O +ATOM 104 O5' A A 4 -6.522 -32.931 -2.419 1.00 1.00 O +ATOM 105 C5' A A 4 -7.947 -32.819 -2.514 1.00 1.00 C +ATOM 106 C4' A A 4 -8.474 -31.642 -1.692 1.00 1.00 C +ATOM 107 O4' A A 4 -8.179 -31.849 -0.313 1.00 1.00 O +ATOM 108 C3' A A 4 -7.871 -30.299 -2.072 1.00 1.00 C +ATOM 109 O3' A A 4 -8.703 -29.661 -3.049 1.00 1.00 O +ATOM 110 C2' A A 4 -7.904 -29.512 -0.770 1.00 1.00 C +ATOM 111 O2' A A 4 -9.102 -28.732 -0.662 1.00 1.00 O +ATOM 112 C1' A A 4 -7.850 -30.597 0.305 1.00 1.00 C +ATOM 113 N9 A A 4 -6.522 -30.751 0.925 1.00 1.00 N +ATOM 114 C8 A A 4 -5.416 -31.394 0.432 1.00 1.00 C +ATOM 115 N7 A A 4 -4.384 -31.353 1.227 1.00 1.00 N +ATOM 116 C5 A A 4 -4.838 -30.630 2.326 1.00 1.00 C +ATOM 117 C6 A A 4 -4.219 -30.236 3.523 1.00 1.00 C +ATOM 118 N6 A A 4 -2.953 -30.530 3.820 1.00 1.00 N +ATOM 119 N1 A A 4 -4.958 -29.530 4.396 1.00 1.00 N +ATOM 120 C2 A A 4 -6.218 -29.240 4.092 1.00 1.00 C +ATOM 121 N3 A A 4 -6.909 -29.551 3.005 1.00 1.00 N +ATOM 122 C4 A A 4 -6.141 -30.260 2.151 1.00 1.00 C +ATOM 123 H5' A A 4 -8.403 -33.738 -2.151 1.00 1.00 H +ATOM 124 H5'' A A 4 -8.223 -32.672 -3.559 1.00 1.00 H +ATOM 125 H4' A A 4 -9.555 -31.588 -1.807 1.00 1.00 H +ATOM 126 H3' A A 4 -6.848 -30.416 -2.433 1.00 1.00 H +ATOM 127 H2' A A 4 -7.020 -28.874 -0.699 1.00 1.00 H +ATOM 128 HO2' A A 4 -9.652 -29.145 0.008 1.00 1.00 H +ATOM 129 H1' A A 4 -8.582 -30.375 1.079 1.00 1.00 H +ATOM 130 H8 A A 4 -5.401 -31.895 -0.536 1.00 1.00 H +ATOM 131 H61 A A 4 -2.557 -30.225 4.691 1.00 1.00 H +ATOM 132 H62 A A 4 -2.392 -31.061 3.170 1.00 1.00 H +ATOM 133 H2 A A 4 -6.759 -28.665 4.843 1.00 1.00 H +ATOM 134 P U A 5 -8.076 -28.642 -4.127 1.00 1.00 P +ATOM 135 OP1 U A 5 -9.185 -28.077 -4.928 1.00 1.00 O +ATOM 136 OP2 U A 5 -6.948 -29.318 -4.805 1.00 1.00 O +ATOM 137 O5' U A 5 -7.475 -27.467 -3.204 1.00 1.00 O +ATOM 138 C5' U A 5 -8.328 -26.449 -2.673 1.00 1.00 C +ATOM 139 C4' U A 5 -7.612 -25.622 -1.609 1.00 1.00 C +ATOM 140 O4' U A 5 -7.036 -26.487 -0.636 1.00 1.00 O +ATOM 141 C3' U A 5 -6.481 -24.761 -2.149 1.00 1.00 C +ATOM 142 O3' U A 5 -6.983 -23.460 -2.472 1.00 1.00 O +ATOM 143 C2' U A 5 -5.510 -24.665 -0.978 1.00 1.00 C +ATOM 144 O2' U A 5 -5.705 -23.454 -0.239 1.00 1.00 O +ATOM 145 C1' U A 5 -5.833 -25.897 -0.124 1.00 1.00 C +ATOM 146 N1 U A 5 -4.781 -26.938 -0.152 1.00 1.00 N +ATOM 147 C2 U A 5 -3.889 -26.978 0.902 1.00 1.00 C +ATOM 148 O2 U A 5 -3.954 -26.190 1.844 1.00 1.00 O +ATOM 149 N3 U A 5 -2.916 -27.959 0.840 1.00 1.00 N +ATOM 150 C4 U A 5 -2.760 -28.890 -0.173 1.00 1.00 C +ATOM 151 O4 U A 5 -1.856 -29.721 -0.127 1.00 1.00 O +ATOM 152 C5 U A 5 -3.736 -28.775 -1.234 1.00 1.00 C +ATOM 153 C6 U A 5 -4.698 -27.822 -1.193 1.00 1.00 C +ATOM 154 H5' U A 5 -9.206 -26.918 -2.228 1.00 1.00 H +ATOM 155 H5'' U A 5 -8.646 -25.792 -3.482 1.00 1.00 H +ATOM 156 H4' U A 5 -8.338 -24.982 -1.112 1.00 1.00 H +ATOM 157 H3' U A 5 -6.008 -25.232 -3.012 1.00 1.00 H +ATOM 158 H2' U A 5 -4.482 -24.730 -1.345 1.00 1.00 H +ATOM 159 HO2' U A 5 -4.904 -22.933 -0.330 1.00 1.00 H +ATOM 160 H1' U A 5 -6.004 -25.586 0.908 1.00 1.00 H +ATOM 161 H3 U A 5 -2.258 -28.000 1.604 1.00 1.00 H +ATOM 162 H5 U A 5 -3.697 -29.464 -2.078 1.00 1.00 H +ATOM 163 H6 U A 5 -5.422 -27.759 -2.006 1.00 1.00 H +ATOM 164 P A A 6 -6.654 -22.782 -3.896 1.00 1.00 P +ATOM 165 OP1 A A 6 -7.260 -23.611 -4.961 1.00 1.00 O +ATOM 166 OP2 A A 6 -5.210 -22.470 -3.936 1.00 1.00 O +ATOM 167 O5' A A 6 -7.464 -21.393 -3.818 1.00 1.00 O +ATOM 168 C5' A A 6 -8.681 -21.308 -3.074 1.00 1.00 C +ATOM 169 C4' A A 6 -8.523 -20.410 -1.851 1.00 1.00 C +ATOM 170 O4' A A 6 -7.329 -20.778 -1.155 1.00 1.00 O +ATOM 171 C3' A A 6 -8.431 -18.919 -2.183 1.00 1.00 C +ATOM 172 O3' A A 6 -9.291 -18.184 -1.308 1.00 1.00 O +ATOM 173 C2' A A 6 -6.984 -18.544 -1.896 1.00 1.00 C +ATOM 174 O2' A A 6 -6.893 -17.244 -1.303 1.00 1.00 O +ATOM 175 C1' A A 6 -6.521 -19.622 -0.931 1.00 1.00 C +ATOM 176 N9 A A 6 -5.113 -20.020 -1.101 1.00 1.00 N +ATOM 177 C8 A A 6 -4.438 -20.339 -2.252 1.00 1.00 C +ATOM 178 N7 A A 6 -3.187 -20.654 -2.059 1.00 1.00 N +ATOM 179 C5 A A 6 -3.021 -20.534 -0.683 1.00 1.00 C +ATOM 180 C6 A A 6 -1.914 -20.733 0.160 1.00 1.00 C +ATOM 181 N6 A A 6 -0.716 -21.113 -0.285 1.00 1.00 N +ATOM 182 N1 A A 6 -2.096 -20.525 1.475 1.00 1.00 N +ATOM 183 C2 A A 6 -3.293 -20.149 1.912 1.00 1.00 C +ATOM 184 N3 A A 6 -4.403 -19.931 1.223 1.00 1.00 N +ATOM 185 C4 A A 6 -4.189 -20.148 -0.091 1.00 1.00 C +ATOM 186 H5' A A 6 -8.970 -22.307 -2.747 1.00 1.00 H +ATOM 187 H5'' A A 6 -9.464 -20.903 -3.715 1.00 1.00 H +ATOM 188 H4' A A 6 -9.370 -20.570 -1.187 1.00 1.00 H +ATOM 189 H3' A A 6 -8.681 -18.735 -3.230 1.00 1.00 H +ATOM 190 H2' A A 6 -6.398 -18.590 -2.817 1.00 1.00 H +ATOM 191 HO2' A A 6 -6.580 -16.641 -1.981 1.00 1.00 H +ATOM 192 H1' A A 6 -6.670 -19.277 0.089 1.00 1.00 H +ATOM 193 H8 A A 6 -4.903 -20.325 -3.237 1.00 1.00 H +ATOM 194 H61 A A 6 0.040 -21.239 0.368 1.00 1.00 H +ATOM 195 H62 A A 6 -0.558 -21.273 -1.277 1.00 1.00 H +ATOM 196 H2 A A 6 -3.371 -19.996 2.988 1.00 1.00 H +ATOM 197 P U A 7 -9.460 -16.593 -1.479 1.00 1.00 P +ATOM 198 OP1 U A 7 -10.906 -16.275 -1.468 1.00 1.00 O +ATOM 199 OP2 U A 7 -8.617 -16.157 -2.615 1.00 1.00 O +ATOM 200 O5' U A 7 -8.809 -16.024 -0.119 1.00 1.00 O +ATOM 201 C5' U A 7 -9.639 -15.533 0.937 1.00 1.00 C +ATOM 202 C4' U A 7 -9.036 -15.822 2.312 1.00 1.00 C +ATOM 203 O4' U A 7 -9.379 -17.152 2.709 1.00 1.00 O +ATOM 204 C3' U A 7 -7.513 -15.702 2.357 1.00 1.00 C +ATOM 205 O3' U A 7 -7.116 -14.915 3.482 1.00 1.00 O +ATOM 206 C2' U A 7 -7.019 -17.126 2.548 1.00 1.00 C +ATOM 207 O2' U A 7 -5.875 -17.170 3.410 1.00 1.00 O +ATOM 208 C1' U A 7 -8.210 -17.835 3.166 1.00 1.00 C +ATOM 209 N1 U A 7 -8.328 -19.256 2.773 1.00 1.00 N +ATOM 210 C2 U A 7 -9.600 -19.789 2.687 1.00 1.00 C +ATOM 211 O2 U A 7 -10.605 -19.125 2.932 1.00 1.00 O +ATOM 212 N3 U A 7 -9.678 -21.118 2.309 1.00 1.00 N +ATOM 213 C4 U A 7 -8.610 -21.947 2.013 1.00 1.00 C +ATOM 214 O4 U A 7 -8.796 -23.117 1.688 1.00 1.00 O +ATOM 215 C5 U A 7 -7.319 -21.307 2.128 1.00 1.00 C +ATOM 216 C6 U A 7 -7.217 -20.007 2.497 1.00 1.00 C +ATOM 217 H5' U A 7 -10.617 -16.010 0.872 1.00 1.00 H +ATOM 218 H5'' U A 7 -9.762 -14.455 0.823 1.00 1.00 H +ATOM 219 H4' U A 7 -9.464 -15.130 3.034 1.00 1.00 H +ATOM 220 H3' U A 7 -7.127 -15.282 1.427 1.00 1.00 H +ATOM 221 H2' U A 7 -6.791 -17.570 1.579 1.00 1.00 H +ATOM 222 HO2' U A 7 -5.517 -18.059 3.365 1.00 1.00 H +ATOM 223 H1' U A 7 -8.150 -17.765 4.251 1.00 1.00 H +ATOM 224 H3 U A 7 -10.602 -21.521 2.242 1.00 1.00 H +ATOM 225 H5 U A 7 -6.415 -21.878 1.916 1.00 1.00 H +ATOM 226 H6 U A 7 -6.231 -19.550 2.577 1.00 1.00 H +ATOM 227 P G A 8 -5.719 -14.119 3.449 1.00 1.00 P +ATOM 228 OP1 G A 8 -5.325 -13.808 4.842 1.00 1.00 O +ATOM 229 OP2 G A 8 -5.832 -13.032 2.452 1.00 1.00 O +ATOM 230 O5' G A 8 -4.700 -15.225 2.873 1.00 1.00 O +ATOM 231 C5' G A 8 -3.686 -15.789 3.709 1.00 1.00 C +ATOM 232 C4' G A 8 -2.307 -15.670 3.063 1.00 1.00 C +ATOM 233 O4' G A 8 -2.045 -16.830 2.269 1.00 1.00 O +ATOM 234 C3' G A 8 -2.170 -14.455 2.155 1.00 1.00 C +ATOM 235 O3' G A 8 -1.501 -13.399 2.851 1.00 1.00 O +ATOM 236 C2' G A 8 -1.294 -14.935 1.013 1.00 1.00 C +ATOM 237 O2' G A 8 0.072 -14.568 1.218 1.00 1.00 O +ATOM 238 C1' G A 8 -1.471 -16.446 1.012 1.00 1.00 C +ATOM 239 N9 G A 8 -2.371 -16.925 -0.051 1.00 1.00 N +ATOM 240 C8 G A 8 -3.689 -17.287 0.052 1.00 1.00 C +ATOM 241 N7 G A 8 -4.225 -17.664 -1.072 1.00 1.00 N +ATOM 242 C5 G A 8 -3.189 -17.548 -1.994 1.00 1.00 C +ATOM 243 C6 G A 8 -3.181 -17.821 -3.390 1.00 1.00 C +ATOM 244 O6 G A 8 -4.105 -18.224 -4.095 1.00 1.00 O +ATOM 245 N1 G A 8 -1.937 -17.574 -3.951 1.00 1.00 N +ATOM 246 C2 G A 8 -0.834 -17.120 -3.260 1.00 1.00 C +ATOM 247 N2 G A 8 0.277 -16.944 -3.975 1.00 1.00 N +ATOM 248 N3 G A 8 -0.839 -16.859 -1.946 1.00 1.00 N +ATOM 249 C4 G A 8 -2.047 -17.095 -1.381 1.00 1.00 C +ATOM 250 H5' G A 8 -3.910 -16.842 3.881 1.00 1.00 H +ATOM 251 H5'' G A 8 -3.679 -15.264 4.664 1.00 1.00 H +ATOM 252 H4' G A 8 -1.555 -15.611 3.848 1.00 1.00 H +ATOM 253 H3' G A 8 -3.146 -14.133 1.789 1.00 1.00 H +ATOM 254 H2' G A 8 -1.665 -14.528 0.077 1.00 1.00 H +ATOM 255 HO2' G A 8 0.093 -13.942 1.946 1.00 1.00 H +ATOM 256 H1' G A 8 -0.500 -16.924 0.898 1.00 1.00 H +ATOM 257 H8 G A 8 -4.237 -17.266 0.994 1.00 1.00 H +ATOM 258 H1 G A 8 -1.854 -17.745 -4.943 1.00 1.00 H +ATOM 259 H21 G A 8 0.273 -17.138 -4.957 1.00 1.00 H +ATOM 260 H22 G A 8 1.116 -16.616 -3.532 1.00 1.00 H +ATOM 261 P G A 9 -1.139 -12.018 2.098 1.00 1.00 P +ATOM 262 OP1 G A 9 -0.238 -12.329 0.967 1.00 1.00 O +ATOM 263 OP2 G A 9 -0.715 -11.038 3.123 1.00 1.00 O +ATOM 264 O5' G A 9 -2.566 -11.538 1.508 1.00 1.00 O +ATOM 265 C5' G A 9 -2.918 -11.724 0.126 1.00 1.00 C +ATOM 266 C4' G A 9 -1.794 -11.298 -0.821 1.00 1.00 C +ATOM 267 O4' G A 9 -1.158 -12.465 -1.356 1.00 1.00 O +ATOM 268 C3' G A 9 -2.251 -10.450 -2.006 1.00 1.00 C +ATOM 269 O3' G A 9 -2.046 -9.063 -1.705 1.00 1.00 O +ATOM 270 C2' G A 9 -1.318 -10.876 -3.127 1.00 1.00 C +ATOM 271 O2' G A 9 -0.135 -10.071 -3.156 1.00 1.00 O +ATOM 272 C1' G A 9 -0.997 -12.321 -2.773 1.00 1.00 C +ATOM 273 N9 G A 9 -1.877 -13.309 -3.431 1.00 1.00 N +ATOM 274 C8 G A 9 -2.741 -14.208 -2.861 1.00 1.00 C +ATOM 275 N7 G A 9 -3.371 -14.956 -3.724 1.00 1.00 N +ATOM 276 C5 G A 9 -2.891 -14.523 -4.956 1.00 1.00 C +ATOM 277 C6 G A 9 -3.214 -14.968 -6.268 1.00 1.00 C +ATOM 278 O6 G A 9 -4.004 -15.850 -6.602 1.00 1.00 O +ATOM 279 N1 G A 9 -2.503 -14.267 -7.233 1.00 1.00 N +ATOM 280 C2 G A 9 -1.595 -13.263 -6.974 1.00 1.00 C +ATOM 281 N2 G A 9 -1.011 -12.706 -8.035 1.00 1.00 N +ATOM 282 N3 G A 9 -1.291 -12.841 -5.742 1.00 1.00 N +ATOM 283 C4 G A 9 -1.975 -13.515 -4.787 1.00 1.00 C +ATOM 284 H5' G A 9 -3.809 -11.136 -0.090 1.00 1.00 H +ATOM 285 H5'' G A 9 -3.141 -12.776 -0.042 1.00 1.00 H +ATOM 286 H4' G A 9 -1.053 -10.736 -0.255 1.00 1.00 H +ATOM 287 H3' G A 9 -3.293 -10.656 -2.260 1.00 1.00 H +ATOM 288 H2' G A 9 -1.839 -10.838 -4.084 1.00 1.00 H +ATOM 289 HO2' G A 9 -0.245 -9.379 -2.500 1.00 1.00 H +ATOM 290 H1' G A 9 0.037 -12.533 -3.039 1.00 1.00 H +ATOM 291 H8 G A 9 -2.887 -14.292 -1.784 1.00 1.00 H +ATOM 292 H1 G A 9 -2.681 -14.529 -8.193 1.00 1.00 H +ATOM 293 H21 G A 9 -1.242 -13.027 -8.965 1.00 1.00 H +ATOM 294 H22 G A 9 -0.335 -11.965 -7.911 1.00 1.00 H +ATOM 295 P A A 10 -3.105 -7.943 -2.178 1.00 1.00 P +ATOM 296 OP1 A A 10 -2.659 -6.633 -1.652 1.00 1.00 O +ATOM 297 OP2 A A 10 -4.468 -8.433 -1.875 1.00 1.00 O +ATOM 298 O5' A A 10 -2.919 -7.930 -3.776 1.00 1.00 O +ATOM 299 C5' A A 10 -1.673 -7.541 -4.357 1.00 1.00 C +ATOM 300 C4' A A 10 -1.636 -7.857 -5.848 1.00 1.00 C +ATOM 301 O4' A A 10 -1.712 -9.261 -6.055 1.00 1.00 O +ATOM 302 C3' A A 10 -2.779 -7.253 -6.643 1.00 1.00 C +ATOM 303 O3' A A 10 -2.429 -5.932 -7.074 1.00 1.00 O +ATOM 304 C2' A A 10 -2.906 -8.184 -7.836 1.00 1.00 C +ATOM 305 O2' A A 10 -2.166 -7.696 -8.961 1.00 1.00 O +ATOM 306 C1' A A 10 -2.335 -9.507 -7.323 1.00 1.00 C +ATOM 307 N9 A A 10 -3.351 -10.555 -7.127 1.00 1.00 N +ATOM 308 C8 A A 10 -4.011 -10.921 -5.982 1.00 1.00 C +ATOM 309 N7 A A 10 -4.849 -11.906 -6.147 1.00 1.00 N +ATOM 310 C5 A A 10 -4.737 -12.216 -7.500 1.00 1.00 C +ATOM 311 C6 A A 10 -5.368 -13.176 -8.308 1.00 1.00 C +ATOM 312 N6 A A 10 -6.274 -14.038 -7.847 1.00 1.00 N +ATOM 313 N1 A A 10 -5.024 -13.210 -9.607 1.00 1.00 N +ATOM 314 C2 A A 10 -4.119 -12.349 -10.060 1.00 1.00 C +ATOM 315 N3 A A 10 -3.460 -11.406 -9.403 1.00 1.00 N +ATOM 316 C4 A A 10 -3.827 -11.397 -8.104 1.00 1.00 C +ATOM 317 H5' A A 10 -0.866 -8.077 -3.860 1.00 1.00 H +ATOM 318 H5'' A A 10 -1.531 -6.469 -4.215 1.00 1.00 H +ATOM 319 H4' A A 10 -0.693 -7.501 -6.259 1.00 1.00 H +ATOM 320 H3' A A 10 -3.699 -7.248 -6.055 1.00 1.00 H +ATOM 321 H2' A A 10 -3.959 -8.313 -8.094 1.00 1.00 H +ATOM 322 HO2' A A 10 -2.802 -7.464 -9.641 1.00 1.00 H +ATOM 323 H1' A A 10 -1.584 -9.868 -8.023 1.00 1.00 H +ATOM 324 H8 A A 10 -3.850 -10.431 -5.020 1.00 1.00 H +ATOM 325 H61 A A 10 -6.699 -14.710 -8.473 1.00 1.00 H +ATOM 326 H62 A A 10 -6.538 -14.020 -6.873 1.00 1.00 H +ATOM 327 H2 A A 10 -3.887 -12.430 -11.122 1.00 1.00 H +ATOM 328 P A A 11 -3.575 -4.847 -7.400 1.00 1.00 P +ATOM 329 OP1 A A 11 -2.955 -3.503 -7.388 1.00 1.00 O +ATOM 330 OP2 A A 11 -4.740 -5.129 -6.534 1.00 1.00 O +ATOM 331 O5' A A 11 -3.980 -5.199 -8.919 1.00 1.00 O +ATOM 332 C5' A A 11 -3.195 -4.714 -10.012 1.00 1.00 C +ATOM 333 C4' A A 11 -3.718 -5.222 -11.356 1.00 1.00 C +ATOM 334 O4' A A 11 -3.800 -6.651 -11.336 1.00 1.00 O +ATOM 335 C3' A A 11 -5.104 -4.708 -11.722 1.00 1.00 C +ATOM 336 O3' A A 11 -4.983 -3.501 -12.486 1.00 1.00 O +ATOM 337 C2' A A 11 -5.655 -5.834 -12.584 1.00 1.00 C +ATOM 338 O2' A A 11 -5.269 -5.691 -13.955 1.00 1.00 O +ATOM 339 C1' A A 11 -5.027 -7.065 -11.951 1.00 1.00 C +ATOM 340 N9 A A 11 -5.864 -7.681 -10.910 1.00 1.00 N +ATOM 341 C8 A A 11 -5.884 -7.443 -9.560 1.00 1.00 C +ATOM 342 N7 A A 11 -6.739 -8.181 -8.907 1.00 1.00 N +ATOM 343 C5 A A 11 -7.326 -8.964 -9.897 1.00 1.00 C +ATOM 344 C6 A A 11 -8.319 -9.956 -9.857 1.00 1.00 C +ATOM 345 N6 A A 11 -8.919 -10.345 -8.731 1.00 1.00 N +ATOM 346 N1 A A 11 -8.666 -10.528 -11.023 1.00 1.00 N +ATOM 347 C2 A A 11 -8.066 -10.137 -12.140 1.00 1.00 C +ATOM 348 N3 A A 11 -7.124 -9.220 -12.307 1.00 1.00 N +ATOM 349 C4 A A 11 -6.799 -8.665 -11.120 1.00 1.00 C +ATOM 350 H5' A A 11 -2.165 -5.045 -9.885 1.00 1.00 H +ATOM 351 H5'' A A 11 -3.221 -3.624 -10.010 1.00 1.00 H +ATOM 352 H4' A A 11 -3.018 -4.932 -12.136 1.00 1.00 H +ATOM 353 H3' A A 11 -5.716 -4.562 -10.829 1.00 1.00 H +ATOM 354 H2' A A 11 -6.738 -5.886 -12.491 1.00 1.00 H +ATOM 355 HO2' A A 11 -6.049 -5.863 -14.489 1.00 1.00 H +ATOM 356 H1' A A 11 -4.815 -7.808 -12.721 1.00 1.00 H +ATOM 357 H8 A A 11 -5.246 -6.702 -9.077 1.00 1.00 H +ATOM 358 H61 A A 11 -9.625 -11.061 -8.757 1.00 1.00 H +ATOM 359 H62 A A 11 -8.664 -9.921 -7.852 1.00 1.00 H +ATOM 360 H2 A A 11 -8.395 -10.640 -13.050 1.00 1.00 H +ATOM 361 P G A 12 -5.828 -2.185 -12.088 1.00 1.00 P +ATOM 362 OP1 G A 12 -5.367 -1.068 -12.942 1.00 1.00 O +ATOM 363 OP2 G A 12 -5.795 -2.046 -10.615 1.00 1.00 O +ATOM 364 O5' G A 12 -7.335 -2.558 -12.522 1.00 1.00 O +ATOM 365 C5' G A 12 -7.755 -2.403 -13.880 1.00 1.00 C +ATOM 366 C4' G A 12 -9.168 -2.942 -14.101 1.00 1.00 C +ATOM 367 O4' G A 12 -9.198 -4.350 -13.892 1.00 1.00 O +ATOM 368 C3' G A 12 -10.230 -2.351 -13.183 1.00 1.00 C +ATOM 369 O3' G A 12 -10.775 -1.167 -13.781 1.00 1.00 O +ATOM 370 C2' G A 12 -11.285 -3.441 -13.140 1.00 1.00 C +ATOM 371 O2' G A 12 -12.288 -3.247 -14.141 1.00 1.00 O +ATOM 372 C1' G A 12 -10.488 -4.718 -13.384 1.00 1.00 C +ATOM 373 N9 G A 12 -10.308 -5.545 -12.182 1.00 1.00 N +ATOM 374 C8 G A 12 -9.256 -5.587 -11.304 1.00 1.00 C +ATOM 375 N7 G A 12 -9.403 -6.460 -10.346 1.00 1.00 N +ATOM 376 C5 G A 12 -10.642 -7.039 -10.607 1.00 1.00 C +ATOM 377 C6 G A 12 -11.338 -8.058 -9.900 1.00 1.00 C +ATOM 378 O6 G A 12 -10.989 -8.661 -8.887 1.00 1.00 O +ATOM 379 N1 G A 12 -12.558 -8.349 -10.497 1.00 1.00 N +ATOM 380 C2 G A 12 -13.048 -7.739 -11.632 1.00 1.00 C +ATOM 381 N2 G A 12 -14.243 -8.152 -12.055 1.00 1.00 N +ATOM 382 N3 G A 12 -12.395 -6.782 -12.298 1.00 1.00 N +ATOM 383 C4 G A 12 -11.203 -6.484 -11.730 1.00 1.00 C +ATOM 384 H5' G A 12 -7.065 -2.941 -14.529 1.00 1.00 H +ATOM 385 H5'' G A 12 -7.735 -1.345 -14.140 1.00 1.00 H +ATOM 386 H4' G A 12 -9.454 -2.747 -15.131 1.00 1.00 H +ATOM 387 H3' G A 12 -9.826 -2.151 -12.188 1.00 1.00 H +ATOM 388 H2' G A 12 -11.731 -3.481 -12.146 1.00 1.00 H +ATOM 389 HO2' G A 12 -12.985 -3.886 -13.972 1.00 1.00 H +ATOM 390 H1' G A 12 -11.001 -5.310 -14.142 1.00 1.00 H +ATOM 391 H8 G A 12 -8.378 -4.949 -11.396 1.00 1.00 H +ATOM 392 H1 G A 12 -13.111 -9.067 -10.052 1.00 1.00 H +ATOM 393 H21 G A 12 -14.735 -8.873 -11.551 1.00 1.00 H +ATOM 394 H22 G A 12 -14.655 -7.741 -12.880 1.00 1.00 H +ATOM 395 P A A 13 -11.634 -0.114 -12.913 1.00 1.00 P +ATOM 396 OP1 A A 13 -11.702 1.157 -13.668 1.00 1.00 O +ATOM 397 OP2 A A 13 -11.115 -0.121 -11.528 1.00 1.00 O +ATOM 398 O5' A A 13 -13.107 -0.771 -12.902 1.00 1.00 O +ATOM 399 C5' A A 13 -13.850 -0.924 -14.117 1.00 1.00 C +ATOM 400 C4' A A 13 -15.099 -1.783 -13.912 1.00 1.00 C +ATOM 401 O4' A A 13 -14.719 -3.105 -13.532 1.00 1.00 O +ATOM 402 C3' A A 13 -16.045 -1.273 -12.835 1.00 1.00 C +ATOM 403 O3' A A 13 -17.017 -0.397 -13.420 1.00 1.00 O +ATOM 404 C2' A A 13 -16.717 -2.544 -12.340 1.00 1.00 C +ATOM 405 O2' A A 13 -17.907 -2.830 -13.084 1.00 1.00 O +ATOM 406 C1' A A 13 -15.650 -3.611 -12.563 1.00 1.00 C +ATOM 407 N9 A A 13 -14.889 -3.946 -11.352 1.00 1.00 N +ATOM 408 C8 A A 13 -13.849 -3.269 -10.768 1.00 1.00 C +ATOM 409 N7 A A 13 -13.388 -3.839 -9.689 1.00 1.00 N +ATOM 410 C5 A A 13 -14.180 -4.977 -9.550 1.00 1.00 C +ATOM 411 C6 A A 13 -14.198 -6.010 -8.598 1.00 1.00 C +ATOM 412 N6 A A 13 -13.360 -6.064 -7.560 1.00 1.00 N +ATOM 413 N1 A A 13 -15.113 -6.980 -8.759 1.00 1.00 N +ATOM 414 C2 A A 13 -15.944 -6.921 -9.793 1.00 1.00 C +ATOM 415 N3 A A 13 -16.026 -6.008 -10.748 1.00 1.00 N +ATOM 416 C4 A A 13 -15.096 -5.049 -10.559 1.00 1.00 C +ATOM 417 H5' A A 13 -13.214 -1.395 -14.866 1.00 1.00 H +ATOM 418 H5'' A A 13 -14.152 0.062 -14.476 1.00 1.00 H +ATOM 419 H4' A A 13 -15.641 -1.842 -14.854 1.00 1.00 H +ATOM 420 H3' A A 13 -15.494 -0.782 -12.030 1.00 1.00 H +ATOM 421 H2' A A 13 -16.939 -2.459 -11.273 1.00 1.00 H +ATOM 422 HO2' A A 13 -17.902 -2.263 -13.858 1.00 1.00 H +ATOM 423 H1' A A 13 -16.115 -4.519 -12.950 1.00 1.00 H +ATOM 424 H8 A A 13 -13.446 -2.338 -11.168 1.00 1.00 H +ATOM 425 H61 A A 13 -13.417 -6.837 -6.902 1.00 1.00 H +ATOM 426 H62 A A 13 -12.670 -5.339 -7.431 1.00 1.00 H +ATOM 427 H2 A A 13 -16.661 -7.740 -9.863 1.00 1.00 H +ATOM 428 P A A 14 -17.524 0.922 -12.643 1.00 1.00 P +ATOM 429 OP1 A A 14 -18.508 1.613 -13.506 1.00 1.00 O +ATOM 430 OP2 A A 14 -16.337 1.654 -12.149 1.00 1.00 O +ATOM 431 O5' A A 14 -18.308 0.320 -11.372 1.00 1.00 O +ATOM 432 C5' A A 14 -19.657 -0.142 -11.493 1.00 1.00 C +ATOM 433 C4' A A 14 -20.144 -0.790 -10.200 1.00 1.00 C +ATOM 434 O4' A A 14 -19.383 -1.961 -9.928 1.00 1.00 O +ATOM 435 C3' A A 14 -20.015 0.092 -8.969 1.00 1.00 C +ATOM 436 O3' A A 14 -21.199 0.880 -8.801 1.00 1.00 O +ATOM 437 C2' A A 14 -19.885 -0.907 -7.835 1.00 1.00 C +ATOM 438 O2' A A 14 -21.154 -1.197 -7.238 1.00 1.00 O +ATOM 439 C1' A A 14 -19.285 -2.140 -8.508 1.00 1.00 C +ATOM 440 N9 A A 14 -17.863 -2.347 -8.186 1.00 1.00 N +ATOM 441 C8 A A 14 -16.761 -1.754 -8.748 1.00 1.00 C +ATOM 442 N7 A A 14 -15.628 -2.163 -8.247 1.00 1.00 N +ATOM 443 C5 A A 14 -16.007 -3.093 -7.283 1.00 1.00 C +ATOM 444 C6 A A 14 -15.270 -3.890 -6.393 1.00 1.00 C +ATOM 445 N6 A A 14 -13.938 -3.875 -6.330 1.00 1.00 N +ATOM 446 N1 A A 14 -15.962 -4.701 -5.573 1.00 1.00 N +ATOM 447 C2 A A 14 -17.288 -4.712 -5.641 1.00 1.00 C +ATOM 448 N3 A A 14 -18.090 -4.013 -6.431 1.00 1.00 N +ATOM 449 C4 A A 14 -17.367 -3.210 -7.240 1.00 1.00 C +ATOM 450 H5' A A 14 -19.711 -0.873 -12.300 1.00 1.00 H +ATOM 451 H5'' A A 14 -20.303 0.703 -11.734 1.00 1.00 H +ATOM 452 H4' A A 14 -21.185 -1.079 -10.320 1.00 1.00 H +ATOM 453 H3' A A 14 -19.125 0.720 -9.035 1.00 1.00 H +ATOM 454 H2' A A 14 -19.189 -0.526 -7.094 1.00 1.00 H +ATOM 455 HO2' A A 14 -21.112 -0.902 -6.325 1.00 1.00 H +ATOM 456 H1' A A 14 -19.850 -3.023 -8.217 1.00 1.00 H +ATOM 457 H8 A A 14 -16.826 -1.008 -9.540 1.00 1.00 H +ATOM 458 H61 A A 14 -13.460 -4.470 -5.670 1.00 1.00 H +ATOM 459 H62 A A 14 -13.409 -3.270 -6.941 1.00 1.00 H +ATOM 460 H2 A A 14 -17.786 -5.390 -4.949 1.00 1.00 H +ATOM 461 P C A 15 -21.172 2.221 -7.902 1.00 1.00 P +ATOM 462 OP1 C A 15 -22.460 2.927 -8.086 1.00 1.00 O +ATOM 463 OP2 C A 15 -19.901 2.930 -8.167 1.00 1.00 O +ATOM 464 O5' C A 15 -21.121 1.650 -6.394 1.00 1.00 O +ATOM 465 C5' C A 15 -22.307 1.160 -5.758 1.00 1.00 C +ATOM 466 C4' C A 15 -22.019 0.622 -4.356 1.00 1.00 C +ATOM 467 O4' C A 15 -21.139 -0.494 -4.430 1.00 1.00 O +ATOM 468 C3' C A 15 -21.355 1.616 -3.420 1.00 1.00 C +ATOM 469 O3' C A 15 -22.351 2.388 -2.739 1.00 1.00 O +ATOM 470 C2' C A 15 -20.617 0.722 -2.435 1.00 1.00 C +ATOM 471 O2' C A 15 -21.424 0.428 -1.289 1.00 1.00 O +ATOM 472 C1' C A 15 -20.323 -0.540 -3.248 1.00 1.00 C +ATOM 473 N1 C A 15 -18.918 -0.643 -3.697 1.00 1.00 N +ATOM 474 C2 C A 15 -18.070 -1.510 -3.025 1.00 1.00 C +ATOM 475 O2 C A 15 -18.491 -2.173 -2.078 1.00 1.00 O +ATOM 476 N3 C A 15 -16.778 -1.602 -3.443 1.00 1.00 N +ATOM 477 C4 C A 15 -16.336 -0.874 -4.478 1.00 1.00 C +ATOM 478 N4 C A 15 -15.064 -0.987 -4.862 1.00 1.00 N +ATOM 479 C5 C A 15 -17.208 0.020 -5.173 1.00 1.00 C +ATOM 480 C6 C A 15 -18.484 0.104 -4.752 1.00 1.00 C +ATOM 481 H5' C A 15 -22.731 0.360 -6.364 1.00 1.00 H +ATOM 482 H5'' C A 15 -23.032 1.971 -5.686 1.00 1.00 H +ATOM 483 H4' C A 15 -22.954 0.289 -3.910 1.00 1.00 H +ATOM 484 H3' C A 15 -20.657 2.255 -3.964 1.00 1.00 H +ATOM 485 H2' C A 15 -19.681 1.195 -2.136 1.00 1.00 H +ATOM 486 HO2' C A 15 -20.827 0.184 -0.577 1.00 1.00 H +ATOM 487 H1' C A 15 -20.583 -1.417 -2.662 1.00 1.00 H +ATOM 488 H41 C A 15 -14.445 -1.615 -4.377 1.00 1.00 H +ATOM 489 H42 C A 15 -14.722 -0.442 -5.640 1.00 1.00 H +ATOM 490 H5 C A 15 -16.852 0.613 -6.017 1.00 1.00 H +ATOM 491 H6 C A 15 -19.177 0.777 -5.260 1.00 1.00 H +ATOM 492 P C A 16 -21.982 3.825 -2.110 1.00 1.00 P +ATOM 493 OP1 C A 16 -23.176 4.346 -1.408 1.00 1.00 O +ATOM 494 OP2 C A 16 -21.330 4.639 -3.161 1.00 1.00 O +ATOM 495 O5' C A 16 -20.875 3.442 -1.005 1.00 1.00 O +ATOM 496 C5' C A 16 -21.235 2.657 0.134 1.00 1.00 C +ATOM 497 C4' C A 16 -20.019 1.981 0.762 1.00 1.00 C +ATOM 498 O4' C A 16 -19.300 1.262 -0.230 1.00 1.00 O +ATOM 499 C3' C A 16 -19.022 2.933 1.399 1.00 1.00 C +ATOM 500 O3' C A 16 -19.348 3.113 2.782 1.00 1.00 O +ATOM 501 C2' C A 16 -17.696 2.196 1.286 1.00 1.00 C +ATOM 502 O2' C A 16 -17.364 1.526 2.506 1.00 1.00 O +ATOM 503 C1' C A 16 -17.919 1.200 0.146 1.00 1.00 C +ATOM 504 N1 C A 16 -17.097 1.459 -1.059 1.00 1.00 N +ATOM 505 C2 C A 16 -15.963 0.679 -1.231 1.00 1.00 C +ATOM 506 O2 C A 16 -15.674 -0.177 -0.398 1.00 1.00 O +ATOM 507 N3 C A 16 -15.194 0.891 -2.333 1.00 1.00 N +ATOM 508 C4 C A 16 -15.522 1.832 -3.230 1.00 1.00 C +ATOM 509 N4 C A 16 -14.746 2.011 -4.299 1.00 1.00 N +ATOM 510 C5 C A 16 -16.689 2.641 -3.056 1.00 1.00 C +ATOM 511 C6 C A 16 -17.444 2.422 -1.962 1.00 1.00 C +ATOM 512 H5' C A 16 -21.948 1.893 -0.174 1.00 1.00 H +ATOM 513 H5'' C A 16 -21.704 3.303 0.876 1.00 1.00 H +ATOM 514 H4' C A 16 -20.361 1.274 1.515 1.00 1.00 H +ATOM 515 H3' C A 16 -18.989 3.885 0.869 1.00 1.00 H +ATOM 516 H2' C A 16 -16.910 2.901 1.007 1.00 1.00 H +ATOM 517 HO2' C A 16 -17.493 0.586 2.361 1.00 1.00 H +ATOM 518 H1' C A 16 -17.708 0.196 0.515 1.00 1.00 H +ATOM 519 H41 C A 16 -13.922 1.443 -4.426 1.00 1.00 H +ATOM 520 H42 C A 16 -14.983 2.716 -4.981 1.00 1.00 H +ATOM 521 H5 C A 16 -16.958 3.406 -3.785 1.00 1.00 H +ATOM 522 H6 C A 16 -18.339 3.022 -1.794 1.00 1.00 H +ATOM 523 P G A 17 -18.576 4.216 3.665 1.00 1.00 P +ATOM 524 OP1 G A 17 -19.416 4.538 4.841 1.00 1.00 O +ATOM 525 OP2 G A 17 -18.125 5.297 2.762 1.00 1.00 O +ATOM 526 O5' G A 17 -17.274 3.413 4.179 1.00 1.00 O +ATOM 527 C5' G A 17 -17.397 2.350 5.132 1.00 1.00 C +ATOM 528 C4' G A 17 -16.032 1.915 5.668 1.00 1.00 C +ATOM 529 O4' G A 17 -15.336 1.134 4.700 1.00 1.00 O +ATOM 530 C3' G A 17 -15.116 3.071 6.033 1.00 1.00 C +ATOM 531 O3' G A 17 -15.309 3.433 7.403 1.00 1.00 O +ATOM 532 C2' G A 17 -13.721 2.505 5.833 1.00 1.00 C +ATOM 533 O2' G A 17 -13.188 1.983 7.054 1.00 1.00 O +ATOM 534 C1' G A 17 -13.927 1.400 4.799 1.00 1.00 C +ATOM 535 N9 G A 17 -13.458 1.758 3.454 1.00 1.00 N +ATOM 536 C8 G A 17 -14.207 2.116 2.363 1.00 1.00 C +ATOM 537 N7 G A 17 -13.498 2.399 1.306 1.00 1.00 N +ATOM 538 C5 G A 17 -12.184 2.213 1.723 1.00 1.00 C +ATOM 539 C6 G A 17 -10.968 2.373 1.001 1.00 1.00 C +ATOM 540 O6 G A 17 -10.815 2.716 -0.170 1.00 1.00 O +ATOM 541 N1 G A 17 -9.865 2.087 1.792 1.00 1.00 N +ATOM 542 C2 G A 17 -9.918 1.697 3.113 1.00 1.00 C +ATOM 543 N2 G A 17 -8.746 1.471 3.707 1.00 1.00 N +ATOM 544 N3 G A 17 -11.059 1.545 3.794 1.00 1.00 N +ATOM 545 C4 G A 17 -12.148 1.820 3.038 1.00 1.00 C +ATOM 546 H5' G A 17 -17.878 1.498 4.652 1.00 1.00 H +ATOM 547 H5'' G A 17 -18.017 2.686 5.964 1.00 1.00 H +ATOM 548 H4' G A 17 -16.187 1.301 6.554 1.00 1.00 H +ATOM 549 H3' G A 17 -15.287 3.924 5.371 1.00 1.00 H +ATOM 550 H2' G A 17 -13.064 3.277 5.424 1.00 1.00 H +ATOM 551 HO2' G A 17 -12.566 1.288 6.820 1.00 1.00 H +ATOM 552 H1' G A 17 -13.412 0.497 5.128 1.00 1.00 H +ATOM 553 H8 G A 17 -15.296 2.162 2.377 1.00 1.00 H +ATOM 554 H1 G A 17 -8.963 2.180 1.347 1.00 1.00 H +ATOM 555 H21 G A 17 -7.887 1.587 3.190 1.00 1.00 H +ATOM 556 H22 G A 17 -8.718 1.182 4.674 1.00 1.00 H +ATOM 557 P G A 18 -14.903 4.900 7.923 1.00 1.00 P +ATOM 558 OP1 G A 18 -15.315 5.021 9.339 1.00 1.00 O +ATOM 559 OP2 G A 18 -15.371 5.891 6.929 1.00 1.00 O +ATOM 560 O5' G A 18 -13.294 4.856 7.868 1.00 1.00 O +ATOM 561 C5' G A 18 -12.563 3.942 8.689 1.00 1.00 C +ATOM 562 C4' G A 18 -11.058 4.060 8.460 1.00 1.00 C +ATOM 563 O4' G A 18 -10.735 3.675 7.128 1.00 1.00 O +ATOM 564 C3' G A 18 -10.503 5.461 8.649 1.00 1.00 C +ATOM 565 O3' G A 18 -10.101 5.640 10.013 1.00 1.00 O +ATOM 566 C2' G A 18 -9.291 5.494 7.729 1.00 1.00 C +ATOM 567 O2' G A 18 -8.081 5.214 8.440 1.00 1.00 O +ATOM 568 C1' G A 18 -9.587 4.416 6.690 1.00 1.00 C +ATOM 569 N9 G A 18 -9.888 4.956 5.354 1.00 1.00 N +ATOM 570 C8 G A 18 -11.092 5.371 4.846 1.00 1.00 C +ATOM 571 N7 G A 18 -11.031 5.794 3.614 1.00 1.00 N +ATOM 572 C5 G A 18 -9.687 5.651 3.277 1.00 1.00 C +ATOM 573 C6 G A 18 -9.017 5.951 2.059 1.00 1.00 C +ATOM 574 O6 G A 18 -9.489 6.411 1.021 1.00 1.00 O +ATOM 575 N1 G A 18 -7.662 5.659 2.138 1.00 1.00 N +ATOM 576 C2 G A 18 -7.028 5.143 3.248 1.00 1.00 C +ATOM 577 N2 G A 18 -5.718 4.928 3.132 1.00 1.00 N +ATOM 578 N3 G A 18 -7.656 4.859 4.395 1.00 1.00 N +ATOM 579 C4 G A 18 -8.980 5.138 4.337 1.00 1.00 C +ATOM 580 H5' G A 18 -12.879 2.924 8.457 1.00 1.00 H +ATOM 581 H5'' G A 18 -12.781 4.151 9.736 1.00 1.00 H +ATOM 582 H4' G A 18 -10.546 3.385 9.144 1.00 1.00 H +ATOM 583 H3' G A 18 -11.237 6.211 8.350 1.00 1.00 H +ATOM 584 H2' G A 18 -9.231 6.464 7.236 1.00 1.00 H +ATOM 585 HO2' G A 18 -7.354 5.336 7.825 1.00 1.00 H +ATOM 586 H1' G A 18 -8.733 3.744 6.618 1.00 1.00 H +ATOM 587 H8 G A 18 -12.019 5.347 5.420 1.00 1.00 H +ATOM 588 H1 G A 18 -7.118 5.846 1.309 1.00 1.00 H +ATOM 589 H21 G A 18 -5.246 5.143 2.264 1.00 1.00 H +ATOM 590 H22 G A 18 -5.196 4.551 3.910 1.00 1.00 H +ATOM 591 P G A 19 -9.859 7.114 10.620 1.00 1.00 P +ATOM 592 OP1 G A 19 -9.764 6.998 12.093 1.00 1.00 O +ATOM 593 OP2 G A 19 -10.849 8.034 10.015 1.00 1.00 O +ATOM 594 O5' G A 19 -8.401 7.500 10.050 1.00 1.00 O +ATOM 595 C5' G A 19 -7.260 6.691 10.358 1.00 1.00 C +ATOM 596 C4' G A 19 -6.037 7.105 9.541 1.00 1.00 C +ATOM 597 O4' G A 19 -6.297 6.911 8.154 1.00 1.00 O +ATOM 598 C3' G A 19 -5.636 8.563 9.713 1.00 1.00 C +ATOM 599 O3' G A 19 -4.649 8.667 10.746 1.00 1.00 O +ATOM 600 C2' G A 19 -5.020 8.933 8.370 1.00 1.00 C +ATOM 601 O2' G A 19 -3.593 8.812 8.400 1.00 1.00 O +ATOM 602 C1' G A 19 -5.642 7.934 7.393 1.00 1.00 C +ATOM 603 N9 G A 19 -6.650 8.527 6.503 1.00 1.00 N +ATOM 604 C8 G A 19 -7.982 8.750 6.740 1.00 1.00 C +ATOM 605 N7 G A 19 -8.616 9.287 5.735 1.00 1.00 N +ATOM 606 C5 G A 19 -7.635 9.432 4.758 1.00 1.00 C +ATOM 607 C6 G A 19 -7.732 9.963 3.442 1.00 1.00 C +ATOM 608 O6 G A 19 -8.722 10.415 2.872 1.00 1.00 O +ATOM 609 N1 G A 19 -6.508 9.928 2.787 1.00 1.00 N +ATOM 610 C2 G A 19 -5.336 9.443 3.327 1.00 1.00 C +ATOM 611 N2 G A 19 -4.259 9.494 2.543 1.00 1.00 N +ATOM 612 N3 G A 19 -5.242 8.943 4.565 1.00 1.00 N +ATOM 613 C4 G A 19 -6.427 8.970 5.220 1.00 1.00 C +ATOM 614 H5' G A 19 -7.495 5.650 10.142 1.00 1.00 H +ATOM 615 H5'' G A 19 -7.030 6.792 11.419 1.00 1.00 H +ATOM 616 H4' G A 19 -5.196 6.475 9.824 1.00 1.00 H +ATOM 617 H3' G A 19 -6.507 9.185 9.929 1.00 1.00 H +ATOM 618 H2' G A 19 -5.313 9.950 8.097 1.00 1.00 H +ATOM 619 HO2' G A 19 -3.360 8.384 9.226 1.00 1.00 H +ATOM 620 H1' G A 19 -4.858 7.482 6.784 1.00 1.00 H +ATOM 621 H8 G A 19 -8.468 8.501 7.683 1.00 1.00 H +ATOM 622 H1 G A 19 -6.498 10.290 1.844 1.00 1.00 H +ATOM 623 H21 G A 19 -4.333 9.871 1.608 1.00 1.00 H +ATOM 624 H22 G A 19 -3.371 9.153 2.883 1.00 1.00 H +ATOM 625 P G A 20 -4.570 9.973 11.686 1.00 1.00 P +ATOM 626 OP1 G A 20 -3.552 9.727 12.733 1.00 1.00 O +ATOM 627 OP2 G A 20 -5.948 10.350 12.074 1.00 1.00 O +ATOM 628 O5' G A 20 -4.001 11.102 10.689 1.00 1.00 O +ATOM 629 C5' G A 20 -4.339 12.477 10.891 1.00 1.00 C +ATOM 630 C4' G A 20 -3.975 13.334 9.676 1.00 1.00 C +ATOM 631 O4' G A 20 -4.192 12.590 8.474 1.00 1.00 O +ATOM 632 C3' G A 20 -4.774 14.627 9.566 1.00 1.00 C +ATOM 633 O3' G A 20 -4.004 15.709 10.104 1.00 1.00 O +ATOM 634 C2' G A 20 -4.959 14.818 8.068 1.00 1.00 C +ATOM 635 O2' G A 20 -3.917 15.627 7.513 1.00 1.00 O +ATOM 636 C1' G A 20 -4.905 13.393 7.524 1.00 1.00 C +ATOM 637 N9 G A 20 -6.226 12.771 7.339 1.00 1.00 N +ATOM 638 C8 G A 20 -6.978 12.084 8.256 1.00 1.00 C +ATOM 639 N7 G A 20 -8.115 11.649 7.791 1.00 1.00 N +ATOM 640 C5 G A 20 -8.121 12.078 6.467 1.00 1.00 C +ATOM 641 C6 G A 20 -9.108 11.897 5.460 1.00 1.00 C +ATOM 642 O6 G A 20 -10.189 11.317 5.544 1.00 1.00 O +ATOM 643 N1 G A 20 -8.726 12.483 4.261 1.00 1.00 N +ATOM 644 C2 G A 20 -7.543 13.159 4.054 1.00 1.00 C +ATOM 645 N2 G A 20 -7.357 13.651 2.829 1.00 1.00 N +ATOM 646 N3 G A 20 -6.611 13.332 5.000 1.00 1.00 N +ATOM 647 C4 G A 20 -6.968 12.766 6.178 1.00 1.00 C +ATOM 648 H5' G A 20 -3.800 12.850 11.761 1.00 1.00 H +ATOM 649 H5'' G A 20 -5.409 12.554 11.077 1.00 1.00 H +ATOM 650 H4' G A 20 -2.918 13.584 9.735 1.00 1.00 H +ATOM 651 H3' G A 20 -5.739 14.539 10.068 1.00 1.00 H +ATOM 652 H2' G A 20 -5.940 15.256 7.867 1.00 1.00 H +ATOM 653 HO2' G A 20 -3.515 16.112 8.236 1.00 1.00 H +ATOM 654 H1' G A 20 -4.371 13.388 6.574 1.00 1.00 H +ATOM 655 H8 G A 20 -6.653 11.913 9.282 1.00 1.00 H +ATOM 656 H1 G A 20 -9.379 12.397 3.497 1.00 1.00 H +ATOM 657 H21 G A 20 -8.062 13.519 2.118 1.00 1.00 H +ATOM 658 H22 G A 20 -6.513 14.155 2.614 1.00 1.00 H +ATOM 659 P A A 21 -4.672 16.766 11.118 1.00 1.00 P +ATOM 660 OP1 A A 21 -3.590 17.574 11.724 1.00 1.00 O +ATOM 661 OP2 A A 21 -5.624 16.039 11.988 1.00 1.00 O +ATOM 662 O5' A A 21 -5.517 17.716 10.131 1.00 1.00 O +ATOM 663 C5' A A 21 -6.667 18.420 10.607 1.00 1.00 C +ATOM 664 C4' A A 21 -7.140 19.461 9.597 1.00 1.00 C +ATOM 665 O4' A A 21 -6.160 20.502 9.487 1.00 1.00 O +ATOM 666 C3' A A 21 -7.376 18.892 8.202 1.00 1.00 C +ATOM 667 O3' A A 21 -8.783 18.737 7.986 1.00 1.00 O +ATOM 668 C2' A A 21 -6.818 19.952 7.263 1.00 1.00 C +ATOM 669 O2' A A 21 -7.844 20.848 6.821 1.00 1.00 O +ATOM 670 C1' A A 21 -5.782 20.673 8.117 1.00 1.00 C +ATOM 671 N9 A A 21 -4.407 20.153 7.971 1.00 1.00 N +ATOM 672 C8 A A 21 -3.717 19.324 8.817 1.00 1.00 C +ATOM 673 N7 A A 21 -2.517 19.025 8.400 1.00 1.00 N +ATOM 674 C5 A A 21 -2.406 19.707 7.192 1.00 1.00 C +ATOM 675 C6 A A 21 -1.370 19.804 6.247 1.00 1.00 C +ATOM 676 N6 A A 21 -0.199 19.181 6.380 1.00 1.00 N +ATOM 677 N1 A A 21 -1.594 20.566 5.164 1.00 1.00 N +ATOM 678 C2 A A 21 -2.764 21.182 5.036 1.00 1.00 C +ATOM 679 N3 A A 21 -3.808 21.169 5.848 1.00 1.00 N +ATOM 680 C4 A A 21 -3.553 20.397 6.925 1.00 1.00 C +ATOM 681 H5' A A 21 -6.420 18.918 11.544 1.00 1.00 H +ATOM 682 H5'' A A 21 -7.473 17.706 10.784 1.00 1.00 H +ATOM 683 H4' A A 21 -8.069 19.901 9.957 1.00 1.00 H +ATOM 684 H3' A A 21 -6.848 17.944 8.074 1.00 1.00 H +ATOM 685 H2' A A 21 -6.328 19.474 6.413 1.00 1.00 H +ATOM 686 HO2' A A 21 -8.214 20.484 6.013 1.00 1.00 H +ATOM 687 H1' A A 21 -5.789 21.735 7.872 1.00 1.00 H +ATOM 688 H8 A A 21 -4.133 18.947 9.751 1.00 1.00 H +ATOM 689 H61 A A 21 0.512 19.285 5.671 1.00 1.00 H +ATOM 690 H62 A A 21 -0.022 18.606 7.192 1.00 1.00 H +ATOM 691 H2 A A 21 -2.878 21.783 4.134 1.00 1.00 H +ATOM 692 P A A 22 -9.347 17.572 7.027 1.00 1.00 P +ATOM 693 OP1 A A 22 -10.607 17.060 7.613 1.00 1.00 O +ATOM 694 OP2 A A 22 -8.239 16.638 6.730 1.00 1.00 O +ATOM 695 O5' A A 22 -9.710 18.370 5.679 1.00 1.00 O +ATOM 696 C5' A A 22 -9.157 17.962 4.425 1.00 1.00 C +ATOM 697 C4' A A 22 -8.356 19.086 3.780 1.00 1.00 C +ATOM 698 O4' A A 22 -7.255 19.425 4.624 1.00 1.00 O +ATOM 699 C3' A A 22 -7.794 18.730 2.409 1.00 1.00 C +ATOM 700 O3' A A 22 -8.624 19.285 1.386 1.00 1.00 O +ATOM 701 C2' A A 22 -6.432 19.403 2.385 1.00 1.00 C +ATOM 702 O2' A A 22 -6.506 20.709 1.806 1.00 1.00 O +ATOM 703 C1' A A 22 -6.049 19.470 3.854 1.00 1.00 C +ATOM 704 N9 A A 22 -5.192 18.358 4.295 1.00 1.00 N +ATOM 705 C8 A A 22 -5.462 17.355 5.191 1.00 1.00 C +ATOM 706 N7 A A 22 -4.464 16.537 5.383 1.00 1.00 N +ATOM 707 C5 A A 22 -3.462 17.033 4.555 1.00 1.00 C +ATOM 708 C6 A A 22 -2.147 16.611 4.299 1.00 1.00 C +ATOM 709 N6 A A 22 -1.597 15.544 4.881 1.00 1.00 N +ATOM 710 N1 A A 22 -1.428 17.331 3.423 1.00 1.00 N +ATOM 711 C2 A A 22 -1.982 18.392 2.848 1.00 1.00 C +ATOM 712 N3 A A 22 -3.200 18.887 3.004 1.00 1.00 N +ATOM 713 C4 A A 22 -3.897 18.142 3.889 1.00 1.00 C +ATOM 714 H5' A A 22 -9.966 17.669 3.756 1.00 1.00 H +ATOM 715 H5'' A A 22 -8.501 17.106 4.588 1.00 1.00 H +ATOM 716 H4' A A 22 -8.996 19.962 3.680 1.00 1.00 H +ATOM 717 H3' A A 22 -7.699 17.649 2.301 1.00 1.00 H +ATOM 718 H2' A A 22 -5.717 18.779 1.843 1.00 1.00 H +ATOM 719 HO2' A A 22 -7.091 20.651 1.047 1.00 1.00 H +ATOM 720 H1' A A 22 -5.535 20.411 4.050 1.00 1.00 H +ATOM 721 H8 A A 22 -6.423 17.251 5.695 1.00 1.00 H +ATOM 722 H61 A A 22 -0.646 15.282 4.662 1.00 1.00 H +ATOM 723 H62 A A 22 -2.132 14.997 5.541 1.00 1.00 H +ATOM 724 H2 A A 22 -1.345 18.930 2.146 1.00 1.00 H +ATOM 725 P A A 23 -9.041 18.407 0.101 1.00 1.00 P +ATOM 726 OP1 A A 23 -9.825 19.269 -0.812 1.00 1.00 O +ATOM 727 OP2 A A 23 -9.616 17.132 0.585 1.00 1.00 O +ATOM 728 O5' A A 23 -7.624 18.088 -0.597 1.00 1.00 O +ATOM 729 C5' A A 23 -7.005 19.038 -1.469 1.00 1.00 C +ATOM 730 C4' A A 23 -5.618 18.573 -1.909 1.00 1.00 C +ATOM 731 O4' A A 23 -4.748 18.526 -0.779 1.00 1.00 O +ATOM 732 C3' A A 23 -5.599 17.189 -2.545 1.00 1.00 C +ATOM 733 O3' A A 23 -5.682 17.310 -3.970 1.00 1.00 O +ATOM 734 C2' A A 23 -4.236 16.638 -2.155 1.00 1.00 C +ATOM 735 O2' A A 23 -3.246 16.936 -3.146 1.00 1.00 O +ATOM 736 C1' A A 23 -3.939 17.346 -0.837 1.00 1.00 C +ATOM 737 N9 A A 23 -4.253 16.534 0.349 1.00 1.00 N +ATOM 738 C8 A A 23 -5.459 16.362 0.978 1.00 1.00 C +ATOM 739 N7 A A 23 -5.408 15.561 2.008 1.00 1.00 N +ATOM 740 C5 A A 23 -4.072 15.176 2.064 1.00 1.00 C +ATOM 741 C6 A A 23 -3.361 14.328 2.931 1.00 1.00 C +ATOM 742 N6 A A 23 -3.927 13.685 3.952 1.00 1.00 N +ATOM 743 N1 A A 23 -2.047 14.172 2.699 1.00 1.00 N +ATOM 744 C2 A A 23 -1.488 14.810 1.680 1.00 1.00 C +ATOM 745 N3 A A 23 -2.045 15.628 0.799 1.00 1.00 N +ATOM 746 C4 A A 23 -3.362 15.766 1.057 1.00 1.00 C +ATOM 747 H5' A A 23 -6.912 19.991 -0.948 1.00 1.00 H +ATOM 748 H5'' A A 23 -7.632 19.175 -2.351 1.00 1.00 H +ATOM 749 H4' A A 23 -5.217 19.292 -2.620 1.00 1.00 H +ATOM 750 H3' A A 23 -6.403 16.565 -2.150 1.00 1.00 H +ATOM 751 H2' A A 23 -4.304 15.561 -1.985 1.00 1.00 H +ATOM 752 HO2' A A 23 -3.524 17.739 -3.594 1.00 1.00 H +ATOM 753 H1' A A 23 -2.887 17.629 -0.809 1.00 1.00 H +ATOM 754 H8 A A 23 -6.376 16.850 0.648 1.00 1.00 H +ATOM 755 H61 A A 23 -3.368 13.088 4.544 1.00 1.00 H +ATOM 756 H62 A A 23 -4.923 13.794 4.140 1.00 1.00 H +ATOM 757 H2 A A 23 -0.421 14.639 1.549 1.00 1.00 H +ATOM 758 P C A 24 -6.387 16.163 -4.858 1.00 1.00 P +ATOM 759 OP1 C A 24 -6.190 16.499 -6.286 1.00 1.00 O +ATOM 760 OP2 C A 24 -7.754 15.946 -4.334 1.00 1.00 O +ATOM 761 O5' C A 24 -5.507 14.855 -4.524 1.00 1.00 O +ATOM 762 C5' C A 24 -4.129 14.786 -4.900 1.00 1.00 C +ATOM 763 C4' C A 24 -3.389 13.702 -4.122 1.00 1.00 C +ATOM 764 O4' C A 24 -3.603 13.882 -2.723 1.00 1.00 O +ATOM 765 C3' C A 24 -3.831 12.282 -4.448 1.00 1.00 C +ATOM 766 O3' C A 24 -3.013 11.747 -5.492 1.00 1.00 O +ATOM 767 C2' C A 24 -3.570 11.526 -3.157 1.00 1.00 C +ATOM 768 O2' C A 24 -2.259 10.950 -3.145 1.00 1.00 O +ATOM 769 C1' C A 24 -3.717 12.601 -2.086 1.00 1.00 C +ATOM 770 N1 C A 24 -5.014 12.564 -1.387 1.00 1.00 N +ATOM 771 C2 C A 24 -5.127 11.706 -0.304 1.00 1.00 C +ATOM 772 O2 C A 24 -4.170 11.016 0.037 1.00 1.00 O +ATOM 773 N3 C A 24 -6.318 11.653 0.356 1.00 1.00 N +ATOM 774 C4 C A 24 -7.354 12.411 -0.031 1.00 1.00 C +ATOM 775 N4 C A 24 -8.505 12.336 0.636 1.00 1.00 N +ATOM 776 C5 C A 24 -7.239 13.298 -1.148 1.00 1.00 C +ATOM 777 C6 C A 24 -6.058 13.342 -1.794 1.00 1.00 C +ATOM 778 H5' C A 24 -3.658 15.749 -4.703 1.00 1.00 H +ATOM 779 H5'' C A 24 -4.062 14.569 -5.966 1.00 1.00 H +ATOM 780 H4' C A 24 -2.323 13.793 -4.319 1.00 1.00 H +ATOM 781 H3' C A 24 -4.889 12.252 -4.712 1.00 1.00 H +ATOM 782 H2' C A 24 -4.332 10.756 -3.017 1.00 1.00 H +ATOM 783 HO2' C A 24 -1.628 11.672 -3.180 1.00 1.00 H +ATOM 784 H1' C A 24 -2.915 12.492 -1.356 1.00 1.00 H +ATOM 785 H41 C A 24 -8.590 11.713 1.423 1.00 1.00 H +ATOM 786 H42 C A 24 -9.291 12.903 0.353 1.00 1.00 H +ATOM 787 H5 C A 24 -8.079 13.915 -1.466 1.00 1.00 H +ATOM 788 H6 C A 24 -5.934 14.007 -2.649 1.00 1.00 H +ATOM 789 P U A 25 -3.529 10.513 -6.389 1.00 1.00 P +ATOM 790 OP1 U A 25 -2.495 10.215 -7.406 1.00 1.00 O +ATOM 791 OP2 U A 25 -4.919 10.796 -6.811 1.00 1.00 O +ATOM 792 O5' U A 25 -3.562 9.298 -5.330 1.00 1.00 O +ATOM 793 C5' U A 25 -2.365 8.870 -4.674 1.00 1.00 C +ATOM 794 C4' U A 25 -2.648 7.797 -3.624 1.00 1.00 C +ATOM 795 O4' U A 25 -3.464 8.327 -2.584 1.00 1.00 O +ATOM 796 C3' U A 25 -3.380 6.578 -4.156 1.00 1.00 C +ATOM 797 O3' U A 25 -2.433 5.603 -4.606 1.00 1.00 O +ATOM 798 C2' U A 25 -4.126 6.050 -2.942 1.00 1.00 C +ATOM 799 O2' U A 25 -3.395 4.999 -2.301 1.00 1.00 O +ATOM 800 C1' U A 25 -4.265 7.271 -2.033 1.00 1.00 C +ATOM 801 N1 U A 25 -5.651 7.772 -1.920 1.00 1.00 N +ATOM 802 C2 U A 25 -6.406 7.346 -0.843 1.00 1.00 C +ATOM 803 O2 U A 25 -5.961 6.569 0.001 1.00 1.00 O +ATOM 804 N3 U A 25 -7.696 7.842 -0.770 1.00 1.00 N +ATOM 805 C4 U A 25 -8.287 8.715 -1.666 1.00 1.00 C +ATOM 806 O4 U A 25 -9.444 9.093 -1.502 1.00 1.00 O +ATOM 807 C5 U A 25 -7.425 9.109 -2.759 1.00 1.00 C +ATOM 808 C6 U A 25 -6.159 8.636 -2.853 1.00 1.00 C +ATOM 809 H5' U A 25 -1.901 9.727 -4.188 1.00 1.00 H +ATOM 810 H5'' U A 25 -1.677 8.466 -5.417 1.00 1.00 H +ATOM 811 H4' U A 25 -1.705 7.477 -3.188 1.00 1.00 H +ATOM 812 H3' U A 25 -4.076 6.855 -4.950 1.00 1.00 H +ATOM 813 H2' U A 25 -5.113 5.705 -3.244 1.00 1.00 H +ATOM 814 HO2' U A 25 -2.919 5.391 -1.566 1.00 1.00 H +ATOM 815 H1' U A 25 -3.890 7.022 -1.040 1.00 1.00 H +ATOM 816 H3 U A 25 -8.259 7.538 0.012 1.00 1.00 H +ATOM 817 H5 U A 25 -7.800 9.795 -3.518 1.00 1.00 H +ATOM 818 H6 U A 25 -5.532 8.948 -3.687 1.00 1.00 H +ATOM 819 P U A 26 -2.913 4.329 -5.466 1.00 1.00 P +ATOM 820 OP1 U A 26 -1.740 3.790 -6.190 1.00 1.00 O +ATOM 821 OP2 U A 26 -4.132 4.707 -6.216 1.00 1.00 O +ATOM 822 O5' U A 26 -3.333 3.271 -4.325 1.00 1.00 O +ATOM 823 C5' U A 26 -2.367 2.784 -3.388 1.00 1.00 C +ATOM 824 C4' U A 26 -3.031 2.022 -2.239 1.00 1.00 C +ATOM 825 O4' U A 26 -3.842 2.906 -1.465 1.00 1.00 O +ATOM 826 C3' U A 26 -3.943 0.892 -2.683 1.00 1.00 C +ATOM 827 O3' U A 26 -3.193 -0.326 -2.809 1.00 1.00 O +ATOM 828 C2' U A 26 -4.947 0.790 -1.544 1.00 1.00 C +ATOM 829 O2' U A 26 -4.545 -0.159 -0.554 1.00 1.00 O +ATOM 830 C1' U A 26 -4.988 2.193 -0.967 1.00 1.00 C +ATOM 831 N1 U A 26 -6.192 2.937 -1.373 1.00 1.00 N +ATOM 832 C2 U A 26 -7.265 2.978 -0.501 1.00 1.00 C +ATOM 833 O2 U A 26 -7.246 2.408 0.587 1.00 1.00 O +ATOM 834 N3 U A 26 -8.366 3.699 -0.928 1.00 1.00 N +ATOM 835 C4 U A 26 -8.485 4.373 -2.132 1.00 1.00 C +ATOM 836 O4 U A 26 -9.514 4.985 -2.409 1.00 1.00 O +ATOM 837 C5 U A 26 -7.317 4.275 -2.979 1.00 1.00 C +ATOM 838 C6 U A 26 -6.227 3.575 -2.583 1.00 1.00 C +ATOM 839 H5' U A 26 -1.812 3.628 -2.980 1.00 1.00 H +ATOM 840 H5'' U A 26 -1.674 2.118 -3.902 1.00 1.00 H +ATOM 841 H4' U A 26 -2.255 1.615 -1.594 1.00 1.00 H +ATOM 842 H3' U A 26 -4.447 1.147 -3.617 1.00 1.00 H +ATOM 843 H2' U A 26 -5.928 0.546 -1.945 1.00 1.00 H +ATOM 844 HO2' U A 26 -5.281 -0.269 0.053 1.00 1.00 H +ATOM 845 H1' U A 26 -4.938 2.142 0.120 1.00 1.00 H +ATOM 846 H3 U A 26 -9.158 3.739 -0.302 1.00 1.00 H +ATOM 847 H5 U A 26 -7.315 4.768 -3.951 1.00 1.00 H +ATOM 848 H6 U A 26 -5.359 3.518 -3.241 1.00 1.00 H +ATOM 849 P G A 27 -3.750 -1.559 -3.697 1.00 1.00 P +ATOM 850 OP1 G A 27 -2.706 -2.606 -3.746 1.00 1.00 O +ATOM 851 OP2 G A 27 -4.313 -1.016 -4.953 1.00 1.00 O +ATOM 852 O5' G A 27 -4.964 -2.103 -2.794 1.00 1.00 O +ATOM 853 C5' G A 27 -4.718 -2.486 -1.442 1.00 1.00 C +ATOM 854 C4' G A 27 -5.993 -2.443 -0.607 1.00 1.00 C +ATOM 855 O4' G A 27 -6.642 -1.191 -0.812 1.00 1.00 O +ATOM 856 C3' G A 27 -7.020 -3.510 -0.944 1.00 1.00 C +ATOM 857 O3' G A 27 -6.798 -4.665 -0.121 1.00 1.00 O +ATOM 858 C2' G A 27 -8.339 -2.860 -0.558 1.00 1.00 C +ATOM 859 O2' G A 27 -8.744 -3.252 0.759 1.00 1.00 O +ATOM 860 C1' G A 27 -8.048 -1.363 -0.622 1.00 1.00 C +ATOM 861 N9 G A 27 -8.765 -0.666 -1.703 1.00 1.00 N +ATOM 862 C8 G A 27 -8.329 -0.301 -2.951 1.00 1.00 C +ATOM 863 N7 G A 27 -9.221 0.340 -3.654 1.00 1.00 N +ATOM 864 C5 G A 27 -10.328 0.405 -2.813 1.00 1.00 C +ATOM 865 C6 G A 27 -11.607 0.988 -3.030 1.00 1.00 C +ATOM 866 O6 G A 27 -12.018 1.578 -4.026 1.00 1.00 O +ATOM 867 N1 G A 27 -12.434 0.830 -1.924 1.00 1.00 N +ATOM 868 C2 G A 27 -12.076 0.192 -0.756 1.00 1.00 C +ATOM 869 N2 G A 27 -13.009 0.134 0.193 1.00 1.00 N +ATOM 870 N3 G A 27 -10.876 -0.354 -0.549 1.00 1.00 N +ATOM 871 C4 G A 27 -10.056 -0.210 -1.617 1.00 1.00 C +ATOM 872 H5' G A 27 -3.987 -1.804 -1.009 1.00 1.00 H +ATOM 873 H5'' G A 27 -4.315 -3.498 -1.425 1.00 1.00 H +ATOM 874 H4' G A 27 -5.730 -2.524 0.445 1.00 1.00 H +ATOM 875 H3' G A 27 -6.998 -3.761 -2.005 1.00 1.00 H +ATOM 876 H2' G A 27 -9.108 -3.120 -1.290 1.00 1.00 H +ATOM 877 HO2' G A 27 -8.464 -2.561 1.362 1.00 1.00 H +ATOM 878 H1' G A 27 -8.328 -0.907 0.326 1.00 1.00 H +ATOM 879 H8 G A 27 -7.332 -0.532 -3.324 1.00 1.00 H +ATOM 880 H1 G A 27 -13.361 1.221 -2.003 1.00 1.00 H +ATOM 881 H21 G A 27 -13.917 0.547 0.036 1.00 1.00 H +ATOM 882 H22 G A 27 -12.807 -0.322 1.072 1.00 1.00 H +ATOM 883 P G A 28 -7.490 -6.078 -0.472 1.00 1.00 P +ATOM 884 OP1 G A 28 -6.645 -7.156 0.090 1.00 1.00 O +ATOM 885 OP2 G A 28 -7.826 -6.086 -1.914 1.00 1.00 O +ATOM 886 O5' G A 28 -8.871 -6.033 0.365 1.00 1.00 O +ATOM 887 C5' G A 28 -8.894 -6.343 1.765 1.00 1.00 C +ATOM 888 C4' G A 28 -10.297 -6.733 2.236 1.00 1.00 C +ATOM 889 O4' G A 28 -11.075 -5.555 2.489 1.00 1.00 O +ATOM 890 C3' G A 28 -11.069 -7.580 1.227 1.00 1.00 C +ATOM 891 O3' G A 28 -11.000 -8.961 1.604 1.00 1.00 O +ATOM 892 C2' G A 28 -12.498 -7.078 1.346 1.00 1.00 C +ATOM 893 O2' G A 28 -13.236 -7.817 2.326 1.00 1.00 O +ATOM 894 C1' G A 28 -12.312 -5.630 1.768 1.00 1.00 C +ATOM 895 N9 G A 28 -12.211 -4.695 0.639 1.00 1.00 N +ATOM 896 C8 G A 28 -11.080 -4.151 0.088 1.00 1.00 C +ATOM 897 N7 G A 28 -11.311 -3.370 -0.929 1.00 1.00 N +ATOM 898 C5 G A 28 -12.695 -3.395 -1.065 1.00 1.00 C +ATOM 899 C6 G A 28 -13.528 -2.732 -2.008 1.00 1.00 C +ATOM 900 O6 G A 28 -13.198 -1.982 -2.925 1.00 1.00 O +ATOM 901 N1 G A 28 -14.868 -3.026 -1.798 1.00 1.00 N +ATOM 902 C2 G A 28 -15.350 -3.854 -0.807 1.00 1.00 C +ATOM 903 N2 G A 28 -16.672 -4.014 -0.766 1.00 1.00 N +ATOM 904 N3 G A 28 -14.569 -4.478 0.082 1.00 1.00 N +ATOM 905 C4 G A 28 -13.257 -4.204 -0.109 1.00 1.00 C +ATOM 906 H5' G A 28 -8.560 -5.471 2.328 1.00 1.00 H +ATOM 907 H5'' G A 28 -8.212 -7.171 1.957 1.00 1.00 H +ATOM 908 H4' G A 28 -10.209 -7.290 3.167 1.00 1.00 H +ATOM 909 H3' G A 28 -10.685 -7.424 0.217 1.00 1.00 H +ATOM 910 H2' G A 28 -12.992 -7.122 0.372 1.00 1.00 H +ATOM 911 HO2' G A 28 -13.826 -7.197 2.763 1.00 1.00 H +ATOM 912 H1' G A 28 -13.134 -5.329 2.416 1.00 1.00 H +ATOM 913 H8 G A 28 -10.079 -4.350 0.470 1.00 1.00 H +ATOM 914 H1 G A 28 -15.523 -2.590 -2.430 1.00 1.00 H +ATOM 915 H21 G A 28 -17.257 -3.539 -1.438 1.00 1.00 H +ATOM 916 H22 G A 28 -17.088 -4.606 -0.064 1.00 1.00 H +ATOM 917 P U A 29 -11.035 -10.117 0.481 1.00 1.00 P +ATOM 918 OP1 U A 29 -10.688 -11.402 1.131 1.00 1.00 O +ATOM 919 OP2 U A 29 -10.257 -9.649 -0.687 1.00 1.00 O +ATOM 920 O5' U A 29 -12.590 -10.169 0.060 1.00 1.00 O +ATOM 921 C5' U A 29 -13.575 -10.659 0.973 1.00 1.00 C +ATOM 922 C4' U A 29 -14.979 -10.610 0.369 1.00 1.00 C +ATOM 923 O4' U A 29 -15.370 -9.253 0.160 1.00 1.00 O +ATOM 924 C3' U A 29 -15.107 -11.316 -0.972 1.00 1.00 C +ATOM 925 O3' U A 29 -15.521 -12.673 -0.765 1.00 1.00 O +ATOM 926 C2' U A 29 -16.203 -10.531 -1.676 1.00 1.00 C +ATOM 927 O2' U A 29 -17.499 -11.065 -1.389 1.00 1.00 O +ATOM 928 C1' U A 29 -16.036 -9.128 -1.107 1.00 1.00 C +ATOM 929 N1 U A 29 -15.208 -8.245 -1.951 1.00 1.00 N +ATOM 930 C2 U A 29 -15.849 -7.447 -2.881 1.00 1.00 C +ATOM 931 O2 U A 29 -17.069 -7.463 -3.027 1.00 1.00 O +ATOM 932 N3 U A 29 -15.035 -6.627 -3.640 1.00 1.00 N +ATOM 933 C4 U A 29 -13.656 -6.536 -3.552 1.00 1.00 C +ATOM 934 O4 U A 29 -13.031 -5.768 -4.280 1.00 1.00 O +ATOM 935 C5 U A 29 -13.072 -7.404 -2.555 1.00 1.00 C +ATOM 936 C6 U A 29 -13.849 -8.218 -1.799 1.00 1.00 C +ATOM 937 H5' U A 29 -13.556 -10.052 1.878 1.00 1.00 H +ATOM 938 H5'' U A 29 -13.336 -11.692 1.233 1.00 1.00 H +ATOM 939 H4' U A 29 -15.677 -11.061 1.073 1.00 1.00 H +ATOM 940 H3' U A 29 -14.170 -11.264 -1.530 1.00 1.00 H +ATOM 941 H2' U A 29 -16.020 -10.514 -2.748 1.00 1.00 H +ATOM 942 HO2' U A 29 -17.832 -11.453 -2.201 1.00 1.00 H +ATOM 943 H1' U A 29 -17.016 -8.674 -0.959 1.00 1.00 H +ATOM 944 H3 U A 29 -15.489 -6.037 -4.324 1.00 1.00 H +ATOM 945 H5 U A 29 -11.992 -7.406 -2.409 1.00 1.00 H +ATOM 946 H6 U A 29 -13.382 -8.863 -1.054 1.00 1.00 H +ATOM 947 P U A 30 -14.994 -13.853 -1.730 1.00 1.00 P +ATOM 948 OP1 U A 30 -15.395 -15.149 -1.134 1.00 1.00 O +ATOM 949 OP2 U A 30 -13.571 -13.595 -2.041 1.00 1.00 O +ATOM 950 O5' U A 30 -15.852 -13.634 -3.077 1.00 1.00 O +ATOM 951 C5' U A 30 -17.188 -14.136 -3.173 1.00 1.00 C +ATOM 952 C4' U A 30 -17.900 -13.619 -4.423 1.00 1.00 C +ATOM 953 O4' U A 30 -17.808 -12.198 -4.483 1.00 1.00 O +ATOM 954 C3' U A 30 -17.333 -14.138 -5.733 1.00 1.00 C +ATOM 955 O3' U A 30 -17.961 -15.377 -6.085 1.00 1.00 O +ATOM 956 C2' U A 30 -17.732 -13.052 -6.718 1.00 1.00 C +ATOM 957 O2' U A 30 -19.033 -13.296 -7.264 1.00 1.00 O +ATOM 958 C1' U A 30 -17.710 -11.790 -5.855 1.00 1.00 C +ATOM 959 N1 U A 30 -16.476 -11.002 -5.991 1.00 1.00 N +ATOM 960 C2 U A 30 -16.442 -10.050 -6.991 1.00 1.00 C +ATOM 961 O2 U A 30 -17.389 -9.869 -7.755 1.00 1.00 O +ATOM 962 N3 U A 30 -15.279 -9.308 -7.085 1.00 1.00 N +ATOM 963 C4 U A 30 -14.162 -9.435 -6.276 1.00 1.00 C +ATOM 964 O4 U A 30 -13.178 -8.719 -6.449 1.00 1.00 O +ATOM 965 C5 U A 30 -14.285 -10.454 -5.258 1.00 1.00 C +ATOM 966 C6 U A 30 -15.416 -11.193 -5.147 1.00 1.00 C +ATOM 967 H5' U A 30 -17.748 -13.825 -2.292 1.00 1.00 H +ATOM 968 H5'' U A 30 -17.157 -15.226 -3.206 1.00 1.00 H +ATOM 969 H4' U A 30 -18.952 -13.888 -4.363 1.00 1.00 H +ATOM 970 H3' U A 30 -16.247 -14.237 -5.679 1.00 1.00 H +ATOM 971 H2' U A 30 -16.987 -12.974 -7.511 1.00 1.00 H +ATOM 972 HO2' U A 30 -18.921 -13.873 -8.023 1.00 1.00 H +ATOM 973 H1' U A 30 -18.564 -11.158 -6.103 1.00 1.00 H +ATOM 974 H3 U A 30 -15.240 -8.608 -7.811 1.00 1.00 H +ATOM 975 H5 U A 30 -13.458 -10.631 -4.571 1.00 1.00 H +ATOM 976 H6 U A 30 -15.483 -11.954 -4.369 1.00 1.00 H +ATOM 977 P C A 31 -17.113 -16.554 -6.790 1.00 1.00 P +ATOM 978 OP1 C A 31 -18.018 -17.703 -7.016 1.00 1.00 O +ATOM 979 OP2 C A 31 -15.861 -16.743 -6.024 1.00 1.00 O +ATOM 980 O5' C A 31 -16.735 -15.921 -8.222 1.00 1.00 O +ATOM 981 C5' C A 31 -17.674 -15.948 -9.300 1.00 1.00 C +ATOM 982 C4' C A 31 -17.251 -15.025 -10.441 1.00 1.00 C +ATOM 983 O4' C A 31 -17.035 -13.705 -9.947 1.00 1.00 O +ATOM 984 C3' C A 31 -15.958 -15.422 -11.131 1.00 1.00 C +ATOM 985 O3' C A 31 -16.219 -16.375 -12.169 1.00 1.00 O +ATOM 986 C2' C A 31 -15.494 -14.106 -11.733 1.00 1.00 C +ATOM 987 O2' C A 31 -16.025 -13.908 -13.050 1.00 1.00 O +ATOM 988 C1' C A 31 -16.032 -13.066 -10.750 1.00 1.00 C +ATOM 989 N1 C A 31 -15.001 -12.520 -9.842 1.00 1.00 N +ATOM 990 C2 C A 31 -14.382 -11.340 -10.219 1.00 1.00 C +ATOM 991 O2 C A 31 -14.676 -10.804 -11.286 1.00 1.00 O +ATOM 992 N3 C A 31 -13.452 -10.801 -9.383 1.00 1.00 N +ATOM 993 C4 C A 31 -13.143 -11.398 -8.224 1.00 1.00 C +ATOM 994 N4 C A 31 -12.227 -10.843 -7.428 1.00 1.00 N +ATOM 995 C5 C A 31 -13.780 -12.616 -7.830 1.00 1.00 C +ATOM 996 C6 C A 31 -14.699 -13.140 -8.664 1.00 1.00 C +ATOM 997 H5' C A 31 -18.647 -15.628 -8.930 1.00 1.00 H +ATOM 998 H5'' C A 31 -17.756 -16.968 -9.676 1.00 1.00 H +ATOM 999 H4' C A 31 -18.048 -14.987 -11.179 1.00 1.00 H +ATOM 1000 H3' C A 31 -15.228 -15.801 -10.410 1.00 1.00 H +ATOM 1001 H2' C A 31 -14.413 -14.066 -11.744 1.00 1.00 H +ATOM 1002 HO2' C A 31 -16.865 -14.369 -13.094 1.00 1.00 H +ATOM 1003 H1' C A 31 -16.491 -12.246 -11.303 1.00 1.00 H +ATOM 1004 H41 C A 31 -11.780 -9.987 -7.699 1.00 1.00 H +ATOM 1005 H42 C A 31 -11.988 -11.284 -6.552 1.00 1.00 H +ATOM 1006 H5 C A 31 -13.531 -13.104 -6.886 1.00 1.00 H +ATOM 1007 H6 C A 31 -15.206 -14.068 -8.396 1.00 1.00 H +ATOM 1008 P U A 32 -15.325 -17.714 -12.300 1.00 1.00 P +ATOM 1009 OP1 U A 32 -16.152 -18.758 -12.947 1.00 1.00 O +ATOM 1010 OP2 U A 32 -14.699 -17.982 -10.986 1.00 1.00 O +ATOM 1011 O5' U A 32 -14.164 -17.274 -13.331 1.00 1.00 O +ATOM 1012 C5' U A 32 -14.500 -16.701 -14.596 1.00 1.00 C +ATOM 1013 C4' U A 32 -13.620 -15.493 -14.937 1.00 1.00 C +ATOM 1014 O4' U A 32 -13.631 -14.549 -13.871 1.00 1.00 O +ATOM 1015 C3' U A 32 -12.153 -15.809 -15.178 1.00 1.00 C +ATOM 1016 O3' U A 32 -11.955 -16.170 -16.550 1.00 1.00 O +ATOM 1017 C2' U A 32 -11.468 -14.476 -14.899 1.00 1.00 C +ATOM 1018 O2' U A 32 -11.254 -13.732 -16.101 1.00 1.00 O +ATOM 1019 C1' U A 32 -12.436 -13.756 -13.960 1.00 1.00 C +ATOM 1020 N1 U A 32 -11.898 -13.547 -12.594 1.00 1.00 N +ATOM 1021 C2 U A 32 -11.304 -12.330 -12.324 1.00 1.00 C +ATOM 1022 O2 U A 32 -11.199 -11.451 -13.176 1.00 1.00 O +ATOM 1023 N3 U A 32 -10.829 -12.159 -11.036 1.00 1.00 N +ATOM 1024 C4 U A 32 -10.897 -13.087 -10.011 1.00 1.00 C +ATOM 1025 O4 U A 32 -10.442 -12.825 -8.899 1.00 1.00 O +ATOM 1026 C5 U A 32 -11.533 -14.330 -10.382 1.00 1.00 C +ATOM 1027 C6 U A 32 -12.006 -14.521 -11.637 1.00 1.00 C +ATOM 1028 H5' U A 32 -15.543 -16.384 -14.574 1.00 1.00 H +ATOM 1029 H5'' U A 32 -14.378 -17.457 -15.374 1.00 1.00 H +ATOM 1030 H4' U A 32 -14.022 -15.008 -15.824 1.00 1.00 H +ATOM 1031 H3' U A 32 -11.797 -16.585 -14.499 1.00 1.00 H +ATOM 1032 H2' U A 32 -10.529 -14.647 -14.381 1.00 1.00 H +ATOM 1033 HO2' U A 32 -10.520 -13.132 -15.939 1.00 1.00 H +ATOM 1034 H1' U A 32 -12.694 -12.788 -14.394 1.00 1.00 H +ATOM 1035 H3 U A 32 -10.392 -11.272 -10.825 1.00 1.00 H +ATOM 1036 H5 U A 32 -11.632 -15.125 -9.643 1.00 1.00 H +ATOM 1037 H6 U A 32 -12.481 -15.469 -11.891 1.00 1.00 H +ATOM 1038 P U A 33 -10.692 -17.068 -16.999 1.00 1.00 P +ATOM 1039 OP1 U A 33 -10.785 -17.294 -18.459 1.00 1.00 O +ATOM 1040 OP2 U A 33 -10.592 -18.224 -16.081 1.00 1.00 O +ATOM 1041 O5' U A 33 -9.435 -16.095 -16.722 1.00 1.00 O +ATOM 1042 C5' U A 33 -9.237 -14.916 -17.510 1.00 1.00 C +ATOM 1043 C4' U A 33 -8.082 -14.063 -16.982 1.00 1.00 C +ATOM 1044 O4' U A 33 -8.400 -13.544 -15.700 1.00 1.00 O +ATOM 1045 C3' U A 33 -6.767 -14.803 -16.820 1.00 1.00 C +ATOM 1046 O3' U A 33 -6.022 -14.725 -18.039 1.00 1.00 O +ATOM 1047 C2' U A 33 -6.050 -14.026 -15.722 1.00 1.00 C +ATOM 1048 O2' U A 33 -5.133 -13.070 -16.265 1.00 1.00 O +ATOM 1049 C1' U A 33 -7.188 -13.340 -14.958 1.00 1.00 C +ATOM 1050 N1 U A 33 -7.406 -13.883 -13.604 1.00 1.00 N +ATOM 1051 C2 U A 33 -6.859 -13.200 -12.535 1.00 1.00 C +ATOM 1052 O2 U A 33 -6.207 -12.167 -12.684 1.00 1.00 O +ATOM 1053 N3 U A 33 -7.086 -13.744 -11.284 1.00 1.00 N +ATOM 1054 C4 U A 33 -7.805 -14.896 -11.014 1.00 1.00 C +ATOM 1055 O4 U A 33 -7.945 -15.291 -9.858 1.00 1.00 O +ATOM 1056 C5 U A 33 -8.340 -15.546 -12.189 1.00 1.00 C +ATOM 1057 C6 U A 33 -8.130 -15.031 -13.425 1.00 1.00 C +ATOM 1058 H5' U A 33 -10.152 -14.323 -17.493 1.00 1.00 H +ATOM 1059 H5'' U A 33 -9.022 -15.208 -18.538 1.00 1.00 H +ATOM 1060 H4' U A 33 -7.930 -13.225 -17.661 1.00 1.00 H +ATOM 1061 H3' U A 33 -6.936 -15.839 -16.521 1.00 1.00 H +ATOM 1062 H2' U A 33 -5.531 -14.724 -15.058 1.00 1.00 H +ATOM 1063 HO2' U A 33 -5.540 -12.698 -17.051 1.00 1.00 H +ATOM 1064 H1' U A 33 -6.983 -12.271 -14.893 1.00 1.00 H +ATOM 1065 H3 U A 33 -6.691 -13.255 -10.493 1.00 1.00 H +ATOM 1066 H5 U A 33 -8.922 -16.461 -12.080 1.00 1.00 H +ATOM 1067 H6 U A 33 -8.547 -15.540 -14.293 1.00 1.00 H +ATOM 1068 P C A 34 -4.716 -15.636 -18.258 1.00 1.00 P +ATOM 1069 OP1 C A 34 -4.088 -15.245 -19.540 1.00 1.00 O +ATOM 1070 OP2 C A 34 -5.087 -17.049 -18.018 1.00 1.00 O +ATOM 1071 O5' C A 34 -3.752 -15.154 -17.061 1.00 1.00 O +ATOM 1072 C5' C A 34 -3.008 -16.106 -16.296 1.00 1.00 C +ATOM 1073 C4' C A 34 -2.012 -15.419 -15.364 1.00 1.00 C +ATOM 1074 O4' C A 34 -2.713 -14.686 -14.363 1.00 1.00 O +ATOM 1075 C3' C A 34 -1.085 -16.378 -14.636 1.00 1.00 C +ATOM 1076 O3' C A 34 0.135 -16.515 -15.369 1.00 1.00 O +ATOM 1077 C2' C A 34 -0.803 -15.690 -13.309 1.00 1.00 C +ATOM 1078 O2' C A 34 0.442 -14.984 -13.343 1.00 1.00 O +ATOM 1079 C1' C A 34 -1.981 -14.732 -13.131 1.00 1.00 C +ATOM 1080 N1 C A 34 -2.925 -15.140 -12.075 1.00 1.00 N +ATOM 1081 C2 C A 34 -2.629 -14.772 -10.773 1.00 1.00 C +ATOM 1082 O2 C A 34 -1.610 -14.129 -10.531 1.00 1.00 O +ATOM 1083 N3 C A 34 -3.492 -15.141 -9.787 1.00 1.00 N +ATOM 1084 C4 C A 34 -4.599 -15.840 -10.068 1.00 1.00 C +ATOM 1085 N4 C A 34 -5.424 -16.184 -9.078 1.00 1.00 N +ATOM 1086 C5 C A 34 -4.908 -16.221 -11.412 1.00 1.00 C +ATOM 1087 C6 C A 34 -4.048 -15.853 -12.379 1.00 1.00 C +ATOM 1088 H5' C A 34 -2.464 -16.760 -16.976 1.00 1.00 H +ATOM 1089 H5'' C A 34 -3.699 -16.704 -15.702 1.00 1.00 H +ATOM 1090 H4' C A 34 -1.411 -14.720 -15.943 1.00 1.00 H +ATOM 1091 H3' C A 34 -1.566 -17.345 -14.481 1.00 1.00 H +ATOM 1092 H2' C A 34 -0.802 -16.429 -12.503 1.00 1.00 H +ATOM 1093 HO2' C A 34 0.361 -14.295 -14.007 1.00 1.00 H +ATOM 1094 H1' C A 34 -1.601 -13.737 -12.903 1.00 1.00 H +ATOM 1095 H41 C A 34 -5.210 -15.918 -8.132 1.00 1.00 H +ATOM 1096 H42 C A 34 -6.261 -16.712 -9.279 1.00 1.00 H +ATOM 1097 H5 C A 34 -5.808 -16.791 -11.644 1.00 1.00 H +ATOM 1098 H6 C A 34 -4.251 -16.125 -13.416 1.00 1.00 H +ATOM 1099 P C A 35 1.178 -17.683 -14.999 1.00 1.00 P +ATOM 1100 OP1 C A 35 2.462 -17.385 -15.672 1.00 1.00 O +ATOM 1101 OP2 C A 35 0.514 -18.988 -15.218 1.00 1.00 O +ATOM 1102 O5' C A 35 1.380 -17.478 -13.415 1.00 1.00 O +ATOM 1103 C5' C A 35 1.265 -18.586 -12.519 1.00 1.00 C +ATOM 1104 C4' C A 35 2.080 -18.368 -11.247 1.00 1.00 C +ATOM 1105 O4' C A 35 1.423 -17.417 -10.409 1.00 1.00 O +ATOM 1106 C3' C A 35 2.276 -19.632 -10.424 1.00 1.00 C +ATOM 1107 O3' C A 35 3.539 -20.219 -10.750 1.00 1.00 O +ATOM 1108 C2' C A 35 2.290 -19.141 -8.985 1.00 1.00 C +ATOM 1109 O2' C A 35 3.626 -18.921 -8.520 1.00 1.00 O +ATOM 1110 C1' C A 35 1.499 -17.837 -9.039 1.00 1.00 C +ATOM 1111 N1 C A 35 0.118 -17.955 -8.532 1.00 1.00 N +ATOM 1112 C2 C A 35 -0.049 -18.148 -7.170 1.00 1.00 C +ATOM 1113 O2 C A 35 0.932 -18.225 -6.435 1.00 1.00 O +ATOM 1114 N3 C A 35 -1.317 -18.250 -6.684 1.00 1.00 N +ATOM 1115 C4 C A 35 -2.375 -18.165 -7.501 1.00 1.00 C +ATOM 1116 N4 C A 35 -3.603 -18.269 -6.992 1.00 1.00 N +ATOM 1117 C5 C A 35 -2.207 -17.966 -8.908 1.00 1.00 C +ATOM 1118 C6 C A 35 -0.949 -17.867 -9.379 1.00 1.00 C +ATOM 1119 H5' C A 35 1.622 -19.486 -13.021 1.00 1.00 H +ATOM 1120 H5'' C A 35 0.217 -18.720 -12.252 1.00 1.00 H +ATOM 1121 H4' C A 35 3.056 -17.972 -11.519 1.00 1.00 H +ATOM 1122 H3' C A 35 1.458 -20.335 -10.589 1.00 1.00 H +ATOM 1123 H2' C A 35 1.773 -19.859 -8.344 1.00 1.00 H +ATOM 1124 HO2' C A 35 3.870 -18.026 -8.765 1.00 1.00 H +ATOM 1125 H1' C A 35 2.024 -17.077 -8.463 1.00 1.00 H +ATOM 1126 H41 C A 35 -3.729 -18.410 -5.999 1.00 1.00 H +ATOM 1127 H42 C A 35 -4.408 -18.206 -7.599 1.00 1.00 H +ATOM 1128 H5 C A 35 -3.067 -17.898 -9.574 1.00 1.00 H +ATOM 1129 H6 C A 35 -0.782 -17.715 -10.445 1.00 1.00 H +ATOM 1130 P U A 36 3.888 -21.714 -10.274 1.00 1.00 P +ATOM 1131 OP1 U A 36 5.128 -22.142 -10.960 1.00 1.00 O +ATOM 1132 OP2 U A 36 2.661 -22.536 -10.385 1.00 1.00 O +ATOM 1133 O5' U A 36 4.220 -21.509 -8.714 1.00 1.00 O +ATOM 1134 C5' U A 36 3.876 -22.515 -7.761 1.00 1.00 C +ATOM 1135 C4' U A 36 3.926 -21.975 -6.336 1.00 1.00 C +ATOM 1136 O4' U A 36 2.843 -21.076 -6.121 1.00 1.00 O +ATOM 1137 C3' U A 36 3.826 -23.051 -5.270 1.00 1.00 C +ATOM 1138 O3' U A 36 5.144 -23.455 -4.884 1.00 1.00 O +ATOM 1139 C2' U A 36 3.130 -22.357 -4.109 1.00 1.00 C +ATOM 1140 O2' U A 36 4.072 -21.895 -3.135 1.00 1.00 O +ATOM 1141 C1' U A 36 2.395 -21.187 -4.764 1.00 1.00 C +ATOM 1142 N1 U A 36 0.930 -21.345 -4.788 1.00 1.00 N +ATOM 1143 C2 U A 36 0.278 -21.379 -3.570 1.00 1.00 C +ATOM 1144 O2 U A 36 0.882 -21.290 -2.503 1.00 1.00 O +ATOM 1145 N3 U A 36 -1.098 -21.518 -3.621 1.00 1.00 N +ATOM 1146 C4 U A 36 -1.865 -21.626 -4.767 1.00 1.00 C +ATOM 1147 O4 U A 36 -3.087 -21.745 -4.695 1.00 1.00 O +ATOM 1148 C5 U A 36 -1.101 -21.581 -5.994 1.00 1.00 C +ATOM 1149 C6 U A 36 0.247 -21.445 -5.970 1.00 1.00 C +ATOM 1150 H5' U A 36 4.575 -23.346 -7.852 1.00 1.00 H +ATOM 1151 H5'' U A 36 2.867 -22.874 -7.971 1.00 1.00 H +ATOM 1152 H4' U A 36 4.859 -21.431 -6.200 1.00 1.00 H +ATOM 1153 H3' U A 36 3.239 -23.899 -5.626 1.00 1.00 H +ATOM 1154 H2' U A 36 2.408 -23.036 -3.650 1.00 1.00 H +ATOM 1155 HO2' U A 36 3.619 -21.256 -2.581 1.00 1.00 H +ATOM 1156 H1' U A 36 2.641 -20.268 -4.232 1.00 1.00 H +ATOM 1157 H3 U A 36 -1.587 -21.543 -2.739 1.00 1.00 H +ATOM 1158 H5 U A 36 -1.617 -21.658 -6.952 1.00 1.00 H +ATOM 1159 H6 U A 36 0.797 -21.417 -6.909 1.00 1.00 H +ATOM 1160 P A A 37 5.439 -24.969 -4.424 1.00 1.00 P +ATOM 1161 OP1 A A 37 6.901 -25.122 -4.252 1.00 1.00 O +ATOM 1162 OP2 A A 37 4.702 -25.882 -5.325 1.00 1.00 O +ATOM 1163 O5' A A 37 4.753 -25.033 -2.970 1.00 1.00 O +ATOM 1164 C5' A A 37 5.247 -24.220 -1.904 1.00 1.00 C +ATOM 1165 C4' A A 37 4.534 -24.522 -0.591 1.00 1.00 C +ATOM 1166 O4' A A 37 3.194 -24.024 -0.658 1.00 1.00 O +ATOM 1167 C3' A A 37 4.465 -26.010 -0.254 1.00 1.00 C +ATOM 1168 O3' A A 37 4.735 -26.200 1.140 1.00 1.00 O +ATOM 1169 C2' A A 37 3.027 -26.403 -0.554 1.00 1.00 C +ATOM 1170 O2' A A 37 2.546 -27.369 0.388 1.00 1.00 O +ATOM 1171 C1' A A 37 2.265 -25.088 -0.439 1.00 1.00 C +ATOM 1172 N9 A A 37 1.175 -24.935 -1.424 1.00 1.00 N +ATOM 1173 C8 A A 37 1.184 -25.218 -2.765 1.00 1.00 C +ATOM 1174 N7 A A 37 0.052 -24.970 -3.364 1.00 1.00 N +ATOM 1175 C5 A A 37 -0.765 -24.489 -2.345 1.00 1.00 C +ATOM 1176 C6 A A 37 -2.098 -24.046 -2.328 1.00 1.00 C +ATOM 1177 N6 A A 37 -2.873 -24.017 -3.413 1.00 1.00 N +ATOM 1178 N1 A A 37 -2.595 -23.634 -1.149 1.00 1.00 N +ATOM 1179 C2 A A 37 -1.818 -23.665 -0.073 1.00 1.00 C +ATOM 1180 N3 A A 37 -0.558 -24.057 0.038 1.00 1.00 N +ATOM 1181 C4 A A 37 -0.088 -24.464 -1.160 1.00 1.00 C +ATOM 1182 H5' A A 37 5.095 -23.171 -2.157 1.00 1.00 H +ATOM 1183 H5'' A A 37 6.314 -24.406 -1.780 1.00 1.00 H +ATOM 1184 H4' A A 37 5.051 -24.004 0.215 1.00 1.00 H +ATOM 1185 H3' A A 37 5.159 -26.582 -0.872 1.00 1.00 H +ATOM 1186 H2' A A 37 2.954 -26.790 -1.572 1.00 1.00 H +ATOM 1187 HO2' A A 37 1.783 -26.987 0.825 1.00 1.00 H +ATOM 1188 H1' A A 37 1.851 -24.998 0.564 1.00 1.00 H +ATOM 1189 H8 A A 37 2.056 -25.615 -3.284 1.00 1.00 H +ATOM 1190 H61 A A 37 -3.825 -23.689 -3.345 1.00 1.00 H +ATOM 1191 H62 A A 37 -2.507 -24.325 -4.303 1.00 1.00 H +ATOM 1192 H2 A A 37 -2.284 -23.319 0.850 1.00 1.00 H +ATOM 1193 P A A 38 6.233 -26.030 1.705 1.00 1.00 P +ATOM 1194 OP1 A A 38 6.351 -24.682 2.304 1.00 1.00 O +ATOM 1195 OP2 A A 38 7.176 -26.449 0.643 1.00 1.00 O +ATOM 1196 O5' A A 38 6.297 -27.117 2.892 1.00 1.00 O +ATOM 1197 C5' A A 38 5.227 -27.234 3.833 1.00 1.00 C +ATOM 1198 C4' A A 38 5.368 -26.229 4.972 1.00 1.00 C +ATOM 1199 O4' A A 38 5.291 -24.901 4.446 1.00 1.00 O +ATOM 1200 C3' A A 38 4.296 -26.361 6.051 1.00 1.00 C +ATOM 1201 O3' A A 38 4.832 -27.055 7.182 1.00 1.00 O +ATOM 1202 C2' A A 38 3.977 -24.927 6.437 1.00 1.00 C +ATOM 1203 O2' A A 38 4.757 -24.502 7.561 1.00 1.00 O +ATOM 1204 C1' A A 38 4.332 -24.138 5.186 1.00 1.00 C +ATOM 1205 N9 A A 38 3.186 -23.884 4.295 1.00 1.00 N +ATOM 1206 C8 A A 38 2.969 -24.340 3.021 1.00 1.00 C +ATOM 1207 N7 A A 38 1.850 -23.925 2.494 1.00 1.00 N +ATOM 1208 C5 A A 38 1.287 -23.135 3.491 1.00 1.00 C +ATOM 1209 C6 A A 38 0.090 -22.401 3.559 1.00 1.00 C +ATOM 1210 N6 A A 38 -0.789 -22.344 2.559 1.00 1.00 N +ATOM 1211 N1 A A 38 -0.158 -21.732 4.697 1.00 1.00 N +ATOM 1212 C2 A A 38 0.720 -21.794 5.691 1.00 1.00 C +ATOM 1213 N3 A A 38 1.872 -22.445 5.748 1.00 1.00 N +ATOM 1214 C4 A A 38 2.094 -23.105 4.593 1.00 1.00 C +ATOM 1215 H5' A A 38 5.226 -28.243 4.246 1.00 1.00 H +ATOM 1216 H5'' A A 38 4.280 -27.060 3.320 1.00 1.00 H +ATOM 1217 H4' A A 38 6.345 -26.358 5.433 1.00 1.00 H +ATOM 1218 H3' A A 38 3.410 -26.864 5.660 1.00 1.00 H +ATOM 1219 H2' A A 38 2.911 -24.827 6.649 1.00 1.00 H +ATOM 1220 HO2' A A 38 4.154 -24.112 8.196 1.00 1.00 H +ATOM 1221 H1' A A 38 4.775 -23.186 5.475 1.00 1.00 H +ATOM 1222 H8 A A 38 3.669 -24.992 2.496 1.00 1.00 H +ATOM 1223 H61 A A 38 -1.635 -21.801 2.660 1.00 1.00 H +ATOM 1224 H62 A A 38 -0.611 -22.843 1.700 1.00 1.00 H +ATOM 1225 H2 A A 38 0.457 -21.228 6.584 1.00 1.00 H +ATOM 1226 P G A 39 3.883 -27.971 8.106 1.00 1.00 P +ATOM 1227 OP1 G A 39 4.656 -28.381 9.300 1.00 1.00 O +ATOM 1228 OP2 G A 39 3.251 -28.997 7.248 1.00 1.00 O +ATOM 1229 O5' G A 39 2.742 -26.936 8.578 1.00 1.00 O +ATOM 1230 C5' G A 39 2.984 -26.026 9.655 1.00 1.00 C +ATOM 1231 C4' G A 39 1.886 -24.966 9.753 1.00 1.00 C +ATOM 1232 O4' G A 39 1.722 -24.334 8.481 1.00 1.00 O +ATOM 1233 C3' G A 39 0.525 -25.518 10.165 1.00 1.00 C +ATOM 1234 O3' G A 39 0.319 -25.299 11.565 1.00 1.00 O +ATOM 1235 C2' G A 39 -0.464 -24.683 9.367 1.00 1.00 C +ATOM 1236 O2' G A 39 -0.894 -23.534 10.104 1.00 1.00 O +ATOM 1237 C1' G A 39 0.333 -24.286 8.135 1.00 1.00 C +ATOM 1238 N9 G A 39 0.130 -25.183 6.984 1.00 1.00 N +ATOM 1239 C8 G A 39 0.811 -26.328 6.659 1.00 1.00 C +ATOM 1240 N7 G A 39 0.393 -26.901 5.566 1.00 1.00 N +ATOM 1241 C5 G A 39 -0.642 -26.076 5.130 1.00 1.00 C +ATOM 1242 C6 G A 39 -1.477 -26.190 3.986 1.00 1.00 C +ATOM 1243 O6 G A 39 -1.469 -27.060 3.118 1.00 1.00 O +ATOM 1244 N1 G A 39 -2.393 -25.148 3.918 1.00 1.00 N +ATOM 1245 C2 G A 39 -2.492 -24.122 4.834 1.00 1.00 C +ATOM 1246 N2 G A 39 -3.434 -23.210 4.597 1.00 1.00 N +ATOM 1247 N3 G A 39 -1.707 -24.013 5.910 1.00 1.00 N +ATOM 1248 C4 G A 39 -0.808 -25.022 5.994 1.00 1.00 C +ATOM 1249 H5' G A 39 3.942 -25.532 9.495 1.00 1.00 H +ATOM 1250 H5'' G A 39 3.023 -26.585 10.590 1.00 1.00 H +ATOM 1251 H4' G A 39 2.193 -24.211 10.474 1.00 1.00 H +ATOM 1252 H3' G A 39 0.439 -26.575 9.910 1.00 1.00 H +ATOM 1253 H2' G A 39 -1.317 -25.296 9.074 1.00 1.00 H +ATOM 1254 HO2' G A 39 -1.709 -23.225 9.699 1.00 1.00 H +ATOM 1255 H1' G A 39 0.068 -23.270 7.846 1.00 1.00 H +ATOM 1256 H8 G A 39 1.629 -26.724 7.261 1.00 1.00 H +ATOM 1257 H1 G A 39 -3.023 -25.161 3.129 1.00 1.00 H +ATOM 1258 H21 G A 39 -4.026 -23.295 3.783 1.00 1.00 H +ATOM 1259 H22 G A 39 -3.557 -22.434 5.232 1.00 1.00 H +ATOM 1260 P U A 40 -0.480 -26.379 12.452 1.00 1.00 P +ATOM 1261 OP1 U A 40 -0.473 -25.918 13.858 1.00 1.00 O +ATOM 1262 OP2 U A 40 0.036 -27.726 12.116 1.00 1.00 O +ATOM 1263 O5' U A 40 -1.985 -26.264 11.892 1.00 1.00 O +ATOM 1264 C5' U A 40 -2.756 -25.080 12.109 1.00 1.00 C +ATOM 1265 C4' U A 40 -4.104 -25.147 11.394 1.00 1.00 C +ATOM 1266 O4' U A 40 -3.908 -25.085 9.983 1.00 1.00 O +ATOM 1267 C3' U A 40 -4.891 -26.418 11.675 1.00 1.00 C +ATOM 1268 O3' U A 40 -5.772 -26.198 12.784 1.00 1.00 O +ATOM 1269 C2' U A 40 -5.696 -26.621 10.400 1.00 1.00 C +ATOM 1270 O2' U A 40 -6.975 -25.981 10.486 1.00 1.00 O +ATOM 1271 C1' U A 40 -4.822 -25.977 9.324 1.00 1.00 C +ATOM 1272 N1 U A 40 -4.007 -26.944 8.559 1.00 1.00 N +ATOM 1273 C2 U A 40 -4.490 -27.378 7.338 1.00 1.00 C +ATOM 1274 O2 U A 40 -5.563 -26.987 6.884 1.00 1.00 O +ATOM 1275 N3 U A 40 -3.694 -28.279 6.655 1.00 1.00 N +ATOM 1276 C4 U A 40 -2.476 -28.778 7.081 1.00 1.00 C +ATOM 1277 O4 U A 40 -1.850 -29.579 6.389 1.00 1.00 O +ATOM 1278 C5 U A 40 -2.048 -28.272 8.366 1.00 1.00 C +ATOM 1279 C6 U A 40 -2.811 -27.387 9.054 1.00 1.00 C +ATOM 1280 H5' U A 40 -2.199 -24.220 11.738 1.00 1.00 H +ATOM 1281 H5'' U A 40 -2.926 -24.956 13.179 1.00 1.00 H +ATOM 1282 H4' U A 40 -4.703 -24.290 11.694 1.00 1.00 H +ATOM 1283 H3' U A 40 -4.222 -27.261 11.855 1.00 1.00 H +ATOM 1284 H2' U A 40 -5.810 -27.688 10.197 1.00 1.00 H +ATOM 1285 HO2' U A 40 -7.243 -26.003 11.408 1.00 1.00 H +ATOM 1286 H1' U A 40 -5.449 -25.406 8.639 1.00 1.00 H +ATOM 1287 H3 U A 40 -4.034 -28.604 5.761 1.00 1.00 H +ATOM 1288 H5 U A 40 -1.100 -28.606 8.787 1.00 1.00 H +ATOM 1289 H6 U A 40 -2.465 -27.022 10.020 1.00 1.00 H +ATOM 1290 P C A 41 -5.862 -27.262 13.994 1.00 1.00 P +ATOM 1291 OP1 C A 41 -6.680 -26.666 15.071 1.00 1.00 O +ATOM 1292 OP2 C A 41 -4.495 -27.745 14.290 1.00 1.00 O +ATOM 1293 O5' C A 41 -6.697 -28.477 13.344 1.00 1.00 O +ATOM 1294 C5' C A 41 -8.070 -28.300 12.987 1.00 1.00 C +ATOM 1295 C4' C A 41 -8.534 -29.349 11.979 1.00 1.00 C +ATOM 1296 O4' C A 41 -7.802 -29.219 10.767 1.00 1.00 O +ATOM 1297 C3' C A 41 -8.350 -30.788 12.432 1.00 1.00 C +ATOM 1298 O3' C A 41 -9.525 -31.230 13.121 1.00 1.00 O +ATOM 1299 C2' C A 41 -8.207 -31.556 11.128 1.00 1.00 C +ATOM 1300 O2' C A 41 -9.447 -32.155 10.733 1.00 1.00 O +ATOM 1301 C1' C A 41 -7.749 -30.499 10.123 1.00 1.00 C +ATOM 1302 N1 C A 41 -6.377 -30.715 9.618 1.00 1.00 N +ATOM 1303 C2 C A 41 -6.249 -31.424 8.434 1.00 1.00 C +ATOM 1304 O2 C A 41 -7.250 -31.844 7.855 1.00 1.00 O +ATOM 1305 N3 C A 41 -4.997 -31.637 7.941 1.00 1.00 N +ATOM 1306 C4 C A 41 -3.918 -31.174 8.584 1.00 1.00 C +ATOM 1307 N4 C A 41 -2.706 -31.401 8.075 1.00 1.00 N +ATOM 1308 C5 C A 41 -4.045 -30.442 9.806 1.00 1.00 C +ATOM 1309 C6 C A 41 -5.288 -30.236 10.285 1.00 1.00 C +ATOM 1310 H5' C A 41 -8.198 -27.308 12.553 1.00 1.00 H +ATOM 1311 H5'' C A 41 -8.684 -28.378 13.885 1.00 1.00 H +ATOM 1312 H4' C A 41 -9.588 -29.183 11.762 1.00 1.00 H +ATOM 1313 H3' C A 41 -7.457 -30.894 13.050 1.00 1.00 H +ATOM 1314 H2' C A 41 -7.429 -32.315 11.236 1.00 1.00 H +ATOM 1315 HO2' C A 41 -10.063 -31.442 10.551 1.00 1.00 H +ATOM 1316 H1' C A 41 -8.442 -30.491 9.279 1.00 1.00 H +ATOM 1317 H41 C A 41 -2.608 -31.920 7.209 1.00 1.00 H +ATOM 1318 H42 C A 41 -1.886 -31.056 8.553 1.00 1.00 H +ATOM 1319 H5 C A 41 -3.168 -30.065 10.332 1.00 1.00 H +ATOM 1320 H6 C A 41 -5.424 -29.683 11.213 1.00 1.00 H +ATOM 1321 P C A 42 -9.538 -32.637 13.907 1.00 1.00 P +ATOM 1322 OP1 C A 42 -10.594 -32.579 14.942 1.00 1.00 O +ATOM 1323 OP2 C A 42 -8.148 -32.967 14.292 1.00 1.00 O +ATOM 1324 O5' C A 42 -10.006 -33.678 12.766 1.00 1.00 O +ATOM 1325 C5' C A 42 -11.284 -33.546 12.132 1.00 1.00 C +ATOM 1326 C4' C A 42 -11.464 -34.557 10.997 1.00 1.00 C +ATOM 1327 O4' C A 42 -10.532 -34.297 9.949 1.00 1.00 O +ATOM 1328 C3' C A 42 -11.249 -36.006 11.404 1.00 1.00 C +ATOM 1329 O3' C A 42 -12.481 -36.582 11.849 1.00 1.00 O +ATOM 1330 C2' C A 42 -10.808 -36.673 10.112 1.00 1.00 C +ATOM 1331 O2' C A 42 -11.923 -37.223 9.403 1.00 1.00 O +ATOM 1332 C1' C A 42 -10.156 -35.537 9.330 1.00 1.00 C +ATOM 1333 N1 C A 42 -8.684 -35.595 9.317 1.00 1.00 N +ATOM 1334 C2 C A 42 -8.077 -36.380 8.349 1.00 1.00 C +ATOM 1335 O2 C A 42 -8.765 -37.011 7.550 1.00 1.00 O +ATOM 1336 N3 C A 42 -6.717 -36.429 8.317 1.00 1.00 N +ATOM 1337 C4 C A 42 -5.983 -35.738 9.199 1.00 1.00 C +ATOM 1338 N4 C A 42 -4.653 -35.808 9.138 1.00 1.00 N +ATOM 1339 C5 C A 42 -6.605 -34.927 10.201 1.00 1.00 C +ATOM 1340 C6 C A 42 -7.952 -34.885 10.223 1.00 1.00 C +ATOM 1341 H5' C A 42 -11.376 -32.538 11.725 1.00 1.00 H +ATOM 1342 H5'' C A 42 -12.067 -33.702 12.873 1.00 1.00 H +ATOM 1343 H4' C A 42 -12.468 -34.452 10.592 1.00 1.00 H +ATOM 1344 H3' C A 42 -10.471 -36.086 12.167 1.00 1.00 H +ATOM 1345 H2' C A 42 -10.071 -37.444 10.329 1.00 1.00 H +ATOM 1346 HO2' C A 42 -11.603 -37.499 8.540 1.00 1.00 H +ATOM 1347 H1' C A 42 -10.521 -35.553 8.304 1.00 1.00 H +ATOM 1348 H41 C A 42 -4.208 -36.379 8.433 1.00 1.00 H +ATOM 1349 H42 C A 42 -4.090 -35.290 9.798 1.00 1.00 H +ATOM 1350 H5 C A 42 -6.010 -34.364 10.920 1.00 1.00 H +ATOM 1351 H6 C A 42 -8.460 -34.281 10.975 1.00 1.00 H +ATOM 1352 P U A 43 -12.480 -37.911 12.760 1.00 1.00 P +ATOM 1353 OP1 U A 43 -13.869 -38.417 12.836 1.00 1.00 O +ATOM 1354 OP2 U A 43 -11.733 -37.621 14.005 1.00 1.00 O +ATOM 1355 O5' U A 43 -11.614 -38.951 11.881 1.00 1.00 O +ATOM 1356 C5' U A 43 -12.153 -39.517 10.682 1.00 1.00 C +ATOM 1357 C4' U A 43 -11.190 -40.516 10.037 1.00 1.00 C +ATOM 1358 O4' U A 43 -10.012 -39.849 9.609 1.00 1.00 O +ATOM 1359 C3' U A 43 -10.739 -41.638 10.964 1.00 1.00 C +ATOM 1360 O3' U A 43 -11.575 -42.792 10.827 1.00 1.00 O +ATOM 1361 C2' U A 43 -9.305 -41.937 10.515 1.00 1.00 C +ATOM 1362 O2' U A 43 -9.218 -43.220 9.882 1.00 1.00 O +ATOM 1363 C1' U A 43 -8.962 -40.814 9.541 1.00 1.00 C +ATOM 1364 N1 U A 43 -7.688 -40.134 9.857 1.00 1.00 N +ATOM 1365 C2 U A 43 -6.552 -40.578 9.205 1.00 1.00 C +ATOM 1366 O2 U A 43 -6.582 -41.496 8.389 1.00 1.00 O +ATOM 1367 N3 U A 43 -5.375 -39.926 9.525 1.00 1.00 N +ATOM 1368 C4 U A 43 -5.237 -38.885 10.427 1.00 1.00 C +ATOM 1369 O4 U A 43 -4.137 -38.375 10.633 1.00 1.00 O +ATOM 1370 C5 U A 43 -6.475 -38.488 11.062 1.00 1.00 C +ATOM 1371 C6 U A 43 -7.640 -39.112 10.764 1.00 1.00 C +ATOM 1372 H5' U A 43 -12.362 -38.717 9.973 1.00 1.00 H +ATOM 1373 H5'' U A 43 -13.085 -40.029 10.919 1.00 1.00 H +ATOM 1374 H4' U A 43 -11.673 -40.955 9.165 1.00 1.00 H +ATOM 1375 H3' U A 43 -10.738 -41.284 11.999 1.00 1.00 H +ATOM 1376 HO3' U A 43 -11.416 -43.351 11.591 1.00 1.00 H +ATOM 1377 H2' U A 43 -8.630 -41.888 11.372 1.00 1.00 H +ATOM 1378 HO2' U A 43 -9.377 -43.089 8.945 1.00 1.00 H +ATOM 1379 H1' U A 43 -8.916 -41.219 8.529 1.00 1.00 H +ATOM 1380 H3 U A 43 -4.537 -40.239 9.056 1.00 1.00 H +ATOM 1381 H5 U A 43 -6.470 -37.677 11.789 1.00 1.00 H +ATOM 1382 H6 U A 43 -8.558 -38.793 11.256 1.00 1.00 H +TER 1383 U A 43 +ATOM 1384 O5' G B 44 -2.251 40.679 15.781 1.00 1.00 O +ATOM 1385 C5' G B 44 -2.840 41.797 15.113 1.00 1.00 C +ATOM 1386 C4' G B 44 -1.842 42.477 14.175 1.00 1.00 C +ATOM 1387 O4' G B 44 -0.787 43.069 14.939 1.00 1.00 O +ATOM 1388 C3' G B 44 -1.201 41.530 13.163 1.00 1.00 C +ATOM 1389 O3' G B 44 -1.847 41.674 11.894 1.00 1.00 O +ATOM 1390 C2' G B 44 0.234 42.015 13.062 1.00 1.00 C +ATOM 1391 O2' G B 44 0.392 42.967 12.004 1.00 1.00 O +ATOM 1392 C1' G B 44 0.481 42.650 14.420 1.00 1.00 C +ATOM 1393 N9 G B 44 1.077 41.732 15.402 1.00 1.00 N +ATOM 1394 C8 G B 44 0.503 41.186 16.520 1.00 1.00 C +ATOM 1395 N7 G B 44 1.297 40.399 17.190 1.00 1.00 N +ATOM 1396 C5 G B 44 2.484 40.424 16.466 1.00 1.00 C +ATOM 1397 C6 G B 44 3.714 39.754 16.712 1.00 1.00 C +ATOM 1398 O6 G B 44 3.998 38.993 17.634 1.00 1.00 O +ATOM 1399 N1 G B 44 4.659 40.050 15.738 1.00 1.00 N +ATOM 1400 C2 G B 44 4.450 40.885 14.661 1.00 1.00 C +ATOM 1401 N2 G B 44 5.482 41.045 13.833 1.00 1.00 N +ATOM 1402 N3 G B 44 3.295 41.516 14.427 1.00 1.00 N +ATOM 1403 C4 G B 44 2.360 41.238 15.368 1.00 1.00 C +ATOM 1404 H5' G B 44 -3.186 42.514 15.862 1.00 1.00 H +ATOM 1405 H5'' G B 44 -3.692 41.457 14.531 1.00 1.00 H +ATOM 1406 H4' G B 44 -2.356 43.268 13.634 1.00 1.00 H +ATOM 1407 H3' G B 44 -1.241 40.498 13.515 1.00 1.00 H +ATOM 1408 H2' G B 44 0.906 41.163 12.922 1.00 1.00 H +ATOM 1409 HO2' G B 44 0.627 43.806 12.408 1.00 1.00 H +ATOM 1410 H1' G B 44 1.128 43.517 14.303 1.00 1.00 H +ATOM 1411 H8 G B 44 -0.524 41.393 16.824 1.00 1.00 H +ATOM 1412 H1 G B 44 5.561 39.608 15.845 1.00 1.00 H +ATOM 1413 H21 G B 44 6.354 40.568 14.012 1.00 1.00 H +ATOM 1414 H22 G B 44 5.393 41.646 13.025 1.00 1.00 H +ATOM 1415 HO5' G B 44 -1.418 40.492 15.345 1.00 1.00 H +ATOM 1416 P G B 45 -1.911 40.438 10.864 1.00 1.00 P +ATOM 1417 OP1 G B 45 -2.467 40.932 9.584 1.00 1.00 O +ATOM 1418 OP2 G B 45 -2.550 39.295 11.552 1.00 1.00 O +ATOM 1419 O5' G B 45 -0.356 40.081 10.632 1.00 1.00 O +ATOM 1420 C5' G B 45 0.517 40.993 9.960 1.00 1.00 C +ATOM 1421 C4' G B 45 1.935 40.434 9.858 1.00 1.00 C +ATOM 1422 O4' G B 45 2.517 40.319 11.151 1.00 1.00 O +ATOM 1423 C3' G B 45 2.019 39.055 9.228 1.00 1.00 C +ATOM 1424 O3' G B 45 2.153 39.193 7.807 1.00 1.00 O +ATOM 1425 C2' G B 45 3.287 38.464 9.832 1.00 1.00 C +ATOM 1426 O2' G B 45 4.412 38.629 8.960 1.00 1.00 O +ATOM 1427 C1' G B 45 3.468 39.246 11.137 1.00 1.00 C +ATOM 1428 N9 G B 45 3.255 38.440 12.348 1.00 1.00 N +ATOM 1429 C8 G B 45 2.108 38.256 13.078 1.00 1.00 C +ATOM 1430 N7 G B 45 2.261 37.481 14.115 1.00 1.00 N +ATOM 1431 C5 G B 45 3.606 37.124 14.072 1.00 1.00 C +ATOM 1432 C6 G B 45 4.357 36.290 14.946 1.00 1.00 C +ATOM 1433 O6 G B 45 3.972 35.692 15.949 1.00 1.00 O +ATOM 1434 N1 G B 45 5.682 36.192 14.543 1.00 1.00 N +ATOM 1435 C2 G B 45 6.220 36.816 13.438 1.00 1.00 C +ATOM 1436 N2 G B 45 7.516 36.602 13.211 1.00 1.00 N +ATOM 1437 N3 G B 45 5.517 37.599 12.615 1.00 1.00 N +ATOM 1438 C4 G B 45 4.222 37.708 12.992 1.00 1.00 C +ATOM 1439 H5' G B 45 0.545 41.933 10.510 1.00 1.00 H +ATOM 1440 H5'' G B 45 0.135 41.180 8.956 1.00 1.00 H +ATOM 1441 H4' G B 45 2.540 41.122 9.272 1.00 1.00 H +ATOM 1442 H3' G B 45 1.146 38.453 9.489 1.00 1.00 H +ATOM 1443 H2' G B 45 3.127 37.408 10.059 1.00 1.00 H +ATOM 1444 HO2' G B 45 4.447 39.554 8.711 1.00 1.00 H +ATOM 1445 H1' G B 45 4.475 39.661 11.168 1.00 1.00 H +ATOM 1446 H8 G B 45 1.155 38.715 12.814 1.00 1.00 H +ATOM 1447 H1 G B 45 6.279 35.614 15.117 1.00 1.00 H +ATOM 1448 H21 G B 45 8.046 36.009 13.832 1.00 1.00 H +ATOM 1449 H22 G B 45 7.967 37.031 12.417 1.00 1.00 H +ATOM 1450 P G B 46 1.730 38.002 6.807 1.00 1.00 P +ATOM 1451 OP1 G B 46 1.637 38.559 5.439 1.00 1.00 O +ATOM 1452 OP2 G B 46 0.571 37.293 7.394 1.00 1.00 O +ATOM 1453 O5' G B 46 3.004 37.019 6.865 1.00 1.00 O +ATOM 1454 C5' G B 46 4.295 37.478 6.449 1.00 1.00 C +ATOM 1455 C4' G B 46 5.396 36.514 6.882 1.00 1.00 C +ATOM 1456 O4' G B 46 5.283 36.251 8.277 1.00 1.00 O +ATOM 1457 C3' G B 46 5.359 35.161 6.185 1.00 1.00 C +ATOM 1458 O3' G B 46 6.177 35.192 5.008 1.00 1.00 O +ATOM 1459 C2' G B 46 5.966 34.214 7.209 1.00 1.00 C +ATOM 1460 O2' G B 46 7.358 33.997 6.959 1.00 1.00 O +ATOM 1461 C1' G B 46 5.743 34.922 8.545 1.00 1.00 C +ATOM 1462 N9 G B 46 4.744 34.260 9.402 1.00 1.00 N +ATOM 1463 C8 G B 46 3.420 34.568 9.581 1.00 1.00 C +ATOM 1464 N7 G B 46 2.806 33.789 10.429 1.00 1.00 N +ATOM 1465 C5 G B 46 3.794 32.900 10.842 1.00 1.00 C +ATOM 1466 C6 G B 46 3.720 31.819 11.764 1.00 1.00 C +ATOM 1467 O6 G B 46 2.748 31.429 12.408 1.00 1.00 O +ATOM 1468 N1 G B 46 4.944 31.176 11.894 1.00 1.00 N +ATOM 1469 C2 G B 46 6.096 31.527 11.224 1.00 1.00 C +ATOM 1470 N2 G B 46 7.176 30.789 11.481 1.00 1.00 N +ATOM 1471 N3 G B 46 6.168 32.542 10.358 1.00 1.00 N +ATOM 1472 C4 G B 46 4.984 33.181 10.218 1.00 1.00 C +ATOM 1473 H5' G B 46 4.483 38.456 6.891 1.00 1.00 H +ATOM 1474 H5'' G B 46 4.307 37.570 5.363 1.00 1.00 H +ATOM 1475 H4' G B 46 6.363 36.978 6.698 1.00 1.00 H +ATOM 1476 H3' G B 46 4.332 34.874 5.950 1.00 1.00 H +ATOM 1477 H2' G B 46 5.422 33.269 7.201 1.00 1.00 H +ATOM 1478 HO2' G B 46 7.541 33.074 7.147 1.00 1.00 H +ATOM 1479 H1' G B 46 6.689 34.976 9.085 1.00 1.00 H +ATOM 1480 H8 G B 46 2.924 35.389 9.063 1.00 1.00 H +ATOM 1481 H1 G B 46 4.970 30.395 12.534 1.00 1.00 H +ATOM 1482 H21 G B 46 7.117 30.022 12.133 1.00 1.00 H +ATOM 1483 H22 G B 46 8.051 30.996 11.020 1.00 1.00 H +ATOM 1484 P A B 47 5.859 34.223 3.755 1.00 1.00 P +ATOM 1485 OP1 A B 47 6.480 34.813 2.547 1.00 1.00 O +ATOM 1486 OP2 A B 47 4.412 33.916 3.761 1.00 1.00 O +ATOM 1487 O5' A B 47 6.659 32.870 4.120 1.00 1.00 O +ATOM 1488 C5' A B 47 8.078 32.782 3.940 1.00 1.00 C +ATOM 1489 C4' A B 47 8.632 31.463 4.478 1.00 1.00 C +ATOM 1490 O4' A B 47 8.395 31.383 5.877 1.00 1.00 O +ATOM 1491 C3' A B 47 8.007 30.223 3.860 1.00 1.00 C +ATOM 1492 O3' A B 47 8.791 29.803 2.737 1.00 1.00 O +ATOM 1493 C2' A B 47 8.093 29.186 4.973 1.00 1.00 C +ATOM 1494 O2' A B 47 9.285 28.401 4.861 1.00 1.00 O +ATOM 1495 C1' A B 47 8.098 30.029 6.250 1.00 1.00 C +ATOM 1496 N9 A B 47 6.805 30.053 6.952 1.00 1.00 N +ATOM 1497 C8 A B 47 5.683 30.784 6.652 1.00 1.00 C +ATOM 1498 N7 A B 47 4.685 30.575 7.465 1.00 1.00 N +ATOM 1499 C5 A B 47 5.181 29.640 8.368 1.00 1.00 C +ATOM 1500 C6 A B 47 4.610 29.004 9.482 1.00 1.00 C +ATOM 1501 N6 A B 47 3.360 29.228 9.890 1.00 1.00 N +ATOM 1502 N1 A B 47 5.380 28.131 10.154 1.00 1.00 N +ATOM 1503 C2 A B 47 6.623 27.913 9.744 1.00 1.00 C +ATOM 1504 N3 A B 47 7.270 28.445 8.717 1.00 1.00 N +ATOM 1505 C4 A B 47 6.472 29.316 8.063 1.00 1.00 C +ATOM 1506 H5' A B 47 8.555 33.609 4.466 1.00 1.00 H +ATOM 1507 H5'' A B 47 8.308 32.857 2.877 1.00 1.00 H +ATOM 1508 H4' A B 47 9.707 31.437 4.310 1.00 1.00 H +ATOM 1509 H3' A B 47 6.969 30.408 3.576 1.00 1.00 H +ATOM 1510 H2' A B 47 7.206 28.548 4.954 1.00 1.00 H +ATOM 1511 HO2' A B 47 9.871 28.667 5.574 1.00 1.00 H +ATOM 1512 H1' A B 47 8.869 29.660 6.926 1.00 1.00 H +ATOM 1513 H8 A B 47 5.630 31.474 5.810 1.00 1.00 H +ATOM 1514 H61 A B 47 2.999 28.746 10.694 1.00 1.00 H +ATOM 1515 H62 A B 47 2.775 29.882 9.389 1.00 1.00 H +ATOM 1516 H2 A B 47 7.191 27.193 10.334 1.00 1.00 H +ATOM 1517 P U B 48 8.112 29.026 1.500 1.00 1.00 P +ATOM 1518 OP1 U B 48 9.183 28.645 0.552 1.00 1.00 O +ATOM 1519 OP2 U B 48 6.961 29.826 1.028 1.00 1.00 O +ATOM 1520 O5' U B 48 7.546 27.685 2.184 1.00 1.00 O +ATOM 1521 C5' U B 48 8.414 26.582 2.457 1.00 1.00 C +ATOM 1522 C4' U B 48 7.739 25.552 3.359 1.00 1.00 C +ATOM 1523 O4' U B 48 7.210 26.201 4.508 1.00 1.00 O +ATOM 1524 C3' U B 48 6.580 24.819 2.707 1.00 1.00 C +ATOM 1525 O3' U B 48 7.056 23.614 2.097 1.00 1.00 O +ATOM 1526 C2' U B 48 5.664 24.478 3.879 1.00 1.00 C +ATOM 1527 O2' U B 48 5.889 23.143 4.343 1.00 1.00 O +ATOM 1528 C1' U B 48 6.034 25.511 4.951 1.00 1.00 C +ATOM 1529 N1 U B 48 4.986 26.531 5.186 1.00 1.00 N +ATOM 1530 C2 U B 48 4.139 26.344 6.260 1.00 1.00 C +ATOM 1531 O2 U B 48 4.236 25.373 7.007 1.00 1.00 O +ATOM 1532 N3 U B 48 3.174 27.317 6.449 1.00 1.00 N +ATOM 1533 C4 U B 48 2.986 28.443 5.666 1.00 1.00 C +ATOM 1534 O4 U B 48 2.092 29.245 5.929 1.00 1.00 O +ATOM 1535 C5 U B 48 3.915 28.557 4.566 1.00 1.00 C +ATOM 1536 C6 U B 48 4.869 27.617 4.360 1.00 1.00 C +ATOM 1537 H5' U B 48 9.314 26.951 2.950 1.00 1.00 H +ATOM 1538 H5'' U B 48 8.693 26.106 1.517 1.00 1.00 H +ATOM 1539 H4' U B 48 8.480 24.826 3.683 1.00 1.00 H +ATOM 1540 H3' U B 48 6.069 25.458 1.984 1.00 1.00 H +ATOM 1541 H2' U B 48 4.620 24.611 3.583 1.00 1.00 H +ATOM 1542 HO2' U B 48 5.084 22.646 4.180 1.00 1.00 H +ATOM 1543 H1' U B 48 6.254 24.996 5.889 1.00 1.00 H +ATOM 1544 H3 U B 48 2.549 27.193 7.232 1.00 1.00 H +ATOM 1545 H5 U B 48 3.847 29.411 3.891 1.00 1.00 H +ATOM 1546 H6 U B 48 5.557 27.727 3.521 1.00 1.00 H +ATOM 1547 P A B 49 6.663 23.249 0.578 1.00 1.00 P +ATOM 1548 OP1 A B 49 7.227 24.285 -0.314 1.00 1.00 O +ATOM 1549 OP2 A B 49 5.216 22.948 0.536 1.00 1.00 O +ATOM 1550 O5' A B 49 7.467 21.877 0.330 1.00 1.00 O +ATOM 1551 C5' A B 49 8.717 21.645 0.984 1.00 1.00 C +ATOM 1552 C4' A B 49 8.611 20.514 2.003 1.00 1.00 C +ATOM 1553 O4' A B 49 7.451 20.725 2.815 1.00 1.00 O +ATOM 1554 C3' A B 49 8.497 19.123 1.377 1.00 1.00 C +ATOM 1555 O3' A B 49 9.393 18.227 2.043 1.00 1.00 O +ATOM 1556 C2' A B 49 7.062 18.690 1.646 1.00 1.00 C +ATOM 1557 O2' A B 49 6.991 17.294 1.958 1.00 1.00 O +ATOM 1558 C1' A B 49 6.649 19.542 2.836 1.00 1.00 C +ATOM 1559 N9 A B 49 5.234 19.958 2.818 1.00 1.00 N +ATOM 1560 C8 A B 49 4.509 20.503 1.789 1.00 1.00 C +ATOM 1561 N7 A B 49 3.269 20.766 2.098 1.00 1.00 N +ATOM 1562 C5 A B 49 3.166 20.365 3.427 1.00 1.00 C +ATOM 1563 C6 A B 49 2.103 20.380 4.345 1.00 1.00 C +ATOM 1564 N6 A B 49 0.885 20.835 4.045 1.00 1.00 N +ATOM 1565 N1 A B 49 2.347 19.907 5.579 1.00 1.00 N +ATOM 1566 C2 A B 49 3.559 19.455 5.872 1.00 1.00 C +ATOM 1567 N3 A B 49 4.635 19.390 5.102 1.00 1.00 N +ATOM 1568 C4 A B 49 4.359 19.871 3.872 1.00 1.00 C +ATOM 1569 H5' A B 49 9.026 22.557 1.494 1.00 1.00 H +ATOM 1570 H5'' A B 49 9.467 21.383 0.236 1.00 1.00 H +ATOM 1571 H4' A B 49 9.489 20.538 2.645 1.00 1.00 H +ATOM 1572 H3' A B 49 8.698 19.158 0.305 1.00 1.00 H +ATOM 1573 H2' A B 49 6.433 18.924 0.783 1.00 1.00 H +ATOM 1574 HO2' A B 49 6.644 16.846 1.185 1.00 1.00 H +ATOM 1575 H1' A B 49 6.846 18.993 3.754 1.00 1.00 H +ATOM 1576 H8 A B 49 4.931 20.697 0.802 1.00 1.00 H +ATOM 1577 H61 A B 49 0.158 20.821 4.745 1.00 1.00 H +ATOM 1578 H62 A B 49 0.683 21.194 3.115 1.00 1.00 H +ATOM 1579 H2 A B 49 3.688 19.085 6.889 1.00 1.00 H +ATOM 1580 P U B 50 9.541 16.702 1.548 1.00 1.00 P +ATOM 1581 OP1 U B 50 10.983 16.393 1.421 1.00 1.00 O +ATOM 1582 OP2 U B 50 8.639 16.502 0.391 1.00 1.00 O +ATOM 1583 O5' U B 50 8.953 15.868 2.796 1.00 1.00 O +ATOM 1584 C5' U B 50 9.828 15.166 3.684 1.00 1.00 C +ATOM 1585 C4' U B 50 9.289 15.158 5.115 1.00 1.00 C +ATOM 1586 O4' U B 50 9.657 16.378 5.763 1.00 1.00 O +ATOM 1587 C3' U B 50 7.768 15.024 5.201 1.00 1.00 C +ATOM 1588 O3' U B 50 7.418 14.016 6.152 1.00 1.00 O +ATOM 1589 C2' U B 50 7.292 16.375 5.708 1.00 1.00 C +ATOM 1590 O2' U B 50 6.192 16.233 6.615 1.00 1.00 O +ATOM 1591 C1' U B 50 8.513 16.949 6.400 1.00 1.00 C +ATOM 1592 N1 U B 50 8.622 18.421 6.299 1.00 1.00 N +ATOM 1593 C2 U B 50 9.892 18.960 6.280 1.00 1.00 C +ATOM 1594 O2 U B 50 10.901 18.260 6.344 1.00 1.00 O +ATOM 1595 N3 U B 50 9.966 20.338 6.187 1.00 1.00 N +ATOM 1596 C4 U B 50 8.894 21.210 6.112 1.00 1.00 C +ATOM 1597 O4 U B 50 9.077 22.423 6.030 1.00 1.00 O +ATOM 1598 C5 U B 50 7.603 20.559 6.139 1.00 1.00 C +ATOM 1599 C6 U B 50 7.506 19.211 6.230 1.00 1.00 C +ATOM 1600 H5' U B 50 10.806 15.647 3.676 1.00 1.00 H +ATOM 1601 H5'' U B 50 9.936 14.137 3.339 1.00 1.00 H +ATOM 1602 H4' U B 50 9.745 14.331 5.656 1.00 1.00 H +ATOM 1603 H3' U B 50 7.338 14.807 4.222 1.00 1.00 H +ATOM 1604 H2' U B 50 7.020 17.009 4.864 1.00 1.00 H +ATOM 1605 HO2' U B 50 5.834 17.111 6.769 1.00 1.00 H +ATOM 1606 H1' U B 50 8.502 16.659 7.451 1.00 1.00 H +ATOM 1607 H3 U B 50 10.890 20.747 6.172 1.00 1.00 H +ATOM 1608 H5 U B 50 6.697 21.161 6.086 1.00 1.00 H +ATOM 1609 H6 U B 50 6.520 18.747 6.250 1.00 1.00 H +ATOM 1610 P G B 51 6.017 13.238 6.014 1.00 1.00 P +ATOM 1611 OP1 G B 51 5.684 12.639 7.325 1.00 1.00 O +ATOM 1612 OP2 G B 51 6.083 12.384 4.806 1.00 1.00 O +ATOM 1613 O5' G B 51 4.978 14.435 5.726 1.00 1.00 O +ATOM 1614 C5' G B 51 4.011 14.813 6.709 1.00 1.00 C +ATOM 1615 C4' G B 51 2.603 14.829 6.121 1.00 1.00 C +ATOM 1616 O4' G B 51 2.313 16.129 5.597 1.00 1.00 O +ATOM 1617 C3' G B 51 2.411 13.828 4.990 1.00 1.00 C +ATOM 1618 O3' G B 51 1.763 12.651 5.482 1.00 1.00 O +ATOM 1619 C2' G B 51 1.491 14.534 4.012 1.00 1.00 C +ATOM 1620 O2' G B 51 0.131 14.133 4.197 1.00 1.00 O +ATOM 1621 C1' G B 51 1.680 16.012 4.315 1.00 1.00 C +ATOM 1622 N9 G B 51 2.534 16.704 3.332 1.00 1.00 N +ATOM 1623 C8 G B 51 3.860 17.036 3.443 1.00 1.00 C +ATOM 1624 N7 G B 51 4.344 17.635 2.393 1.00 1.00 N +ATOM 1625 C5 G B 51 3.263 17.709 1.520 1.00 1.00 C +ATOM 1626 C6 G B 51 3.187 18.263 0.212 1.00 1.00 C +ATOM 1627 O6 G B 51 4.076 18.804 -0.442 1.00 1.00 O +ATOM 1628 N1 G B 51 1.911 18.132 -0.322 1.00 1.00 N +ATOM 1629 C2 G B 51 0.842 17.544 0.320 1.00 1.00 C +ATOM 1630 N2 G B 51 -0.306 17.513 -0.358 1.00 1.00 N +ATOM 1631 N3 G B 51 0.911 17.023 1.549 1.00 1.00 N +ATOM 1632 C4 G B 51 2.150 17.141 2.087 1.00 1.00 C +ATOM 1633 H5' G B 51 4.253 15.809 7.082 1.00 1.00 H +ATOM 1634 H5'' G B 51 4.046 14.104 7.536 1.00 1.00 H +ATOM 1635 H4' G B 51 1.888 14.608 6.913 1.00 1.00 H +ATOM 1636 H3' G B 51 3.366 13.586 4.521 1.00 1.00 H +ATOM 1637 H2' G B 51 1.817 14.329 2.996 1.00 1.00 H +ATOM 1638 HO2' G B 51 0.135 13.369 4.780 1.00 1.00 H +ATOM 1639 H1' G B 51 0.708 16.501 4.349 1.00 1.00 H +ATOM 1640 H8 G B 51 4.454 16.818 4.331 1.00 1.00 H +ATOM 1641 H1 G B 51 1.779 18.502 -1.252 1.00 1.00 H +ATOM 1642 H21 G B 51 -0.350 17.904 -1.280 1.00 1.00 H +ATOM 1643 H22 G B 51 -1.124 17.098 0.054 1.00 1.00 H +ATOM 1644 P G B 52 1.363 11.453 4.479 1.00 1.00 P +ATOM 1645 OP1 G B 52 0.413 11.986 3.477 1.00 1.00 O +ATOM 1646 OP2 G B 52 0.981 10.280 5.297 1.00 1.00 O +ATOM 1647 O5' G B 52 2.760 11.114 3.739 1.00 1.00 O +ATOM 1648 C5' G B 52 3.050 11.580 2.410 1.00 1.00 C +ATOM 1649 C4' G B 52 1.882 11.354 1.448 1.00 1.00 C +ATOM 1650 O4' G B 52 1.226 12.604 1.192 1.00 1.00 O +ATOM 1651 C3' G B 52 2.282 10.766 0.096 1.00 1.00 C +ATOM 1652 O3' G B 52 2.082 9.348 0.114 1.00 1.00 O +ATOM 1653 C2' G B 52 1.304 11.412 -0.872 1.00 1.00 C +ATOM 1654 O2' G B 52 0.115 10.627 -1.015 1.00 1.00 O +ATOM 1655 C1' G B 52 1.009 12.751 -0.217 1.00 1.00 C +ATOM 1656 N9 G B 52 1.866 13.856 -0.697 1.00 1.00 N +ATOM 1657 C8 G B 52 2.763 14.619 0.007 1.00 1.00 C +ATOM 1658 N7 G B 52 3.358 15.532 -0.711 1.00 1.00 N +ATOM 1659 C5 G B 52 2.817 15.362 -1.983 1.00 1.00 C +ATOM 1660 C6 G B 52 3.080 16.072 -3.187 1.00 1.00 C +ATOM 1661 O6 G B 52 3.858 17.006 -3.369 1.00 1.00 O +ATOM 1662 N1 G B 52 2.320 15.584 -4.243 1.00 1.00 N +ATOM 1663 C2 G B 52 1.419 14.544 -4.153 1.00 1.00 C +ATOM 1664 N2 G B 52 0.782 14.218 -5.278 1.00 1.00 N +ATOM 1665 N3 G B 52 1.171 13.876 -3.023 1.00 1.00 N +ATOM 1666 C4 G B 52 1.903 14.338 -1.983 1.00 1.00 C +ATOM 1667 H5' G B 52 3.928 11.051 2.038 1.00 1.00 H +ATOM 1668 H5'' G B 52 3.272 12.644 2.450 1.00 1.00 H +ATOM 1669 H4' G B 52 1.165 10.684 1.920 1.00 1.00 H +ATOM 1670 H3' G B 52 3.312 11.025 -0.158 1.00 1.00 H +ATOM 1671 H2' G B 52 1.781 11.572 -1.839 1.00 1.00 H +ATOM 1672 HO2' G B 52 0.245 9.818 -0.515 1.00 1.00 H +ATOM 1673 H1' G B 52 -0.034 13.012 -0.391 1.00 1.00 H +ATOM 1674 H8 G B 52 2.960 14.478 1.070 1.00 1.00 H +ATOM 1675 H1 G B 52 2.453 16.040 -5.134 1.00 1.00 H +ATOM 1676 H21 G B 52 0.973 14.727 -6.134 1.00 1.00 H +ATOM 1677 H22 G B 52 0.109 13.465 -5.277 1.00 1.00 H +ATOM 1678 P A B 53 3.113 8.353 -0.627 1.00 1.00 P +ATOM 1679 OP1 A B 53 2.682 6.961 -0.364 1.00 1.00 O +ATOM 1680 OP2 A B 53 4.490 8.774 -0.289 1.00 1.00 O +ATOM 1681 O5' A B 53 2.858 8.670 -2.183 1.00 1.00 O +ATOM 1682 C5' A B 53 1.586 8.402 -2.778 1.00 1.00 C +ATOM 1683 C4' A B 53 1.483 9.020 -4.167 1.00 1.00 C +ATOM 1684 O4' A B 53 1.558 10.437 -4.081 1.00 1.00 O +ATOM 1685 C3' A B 53 2.585 8.600 -5.122 1.00 1.00 C +ATOM 1686 O3' A B 53 2.209 7.395 -5.800 1.00 1.00 O +ATOM 1687 C2' A B 53 2.660 9.758 -6.100 1.00 1.00 C +ATOM 1688 O2' A B 53 1.867 9.509 -7.266 1.00 1.00 O +ATOM 1689 C1' A B 53 2.121 10.943 -5.299 1.00 1.00 C +ATOM 1690 N9 A B 53 3.151 11.933 -4.940 1.00 1.00 N +ATOM 1691 C8 A B 53 3.862 12.057 -3.774 1.00 1.00 C +ATOM 1692 N7 A B 53 4.698 13.060 -3.771 1.00 1.00 N +ATOM 1693 C5 A B 53 4.527 13.640 -5.024 1.00 1.00 C +ATOM 1694 C6 A B 53 5.126 14.748 -5.647 1.00 1.00 C +ATOM 1695 N6 A B 53 6.057 15.501 -5.060 1.00 1.00 N +ATOM 1696 N1 A B 53 4.724 15.045 -6.894 1.00 1.00 N +ATOM 1697 C2 A B 53 3.796 14.292 -7.473 1.00 1.00 C +ATOM 1698 N3 A B 53 3.162 13.232 -6.994 1.00 1.00 N +ATOM 1699 C4 A B 53 3.587 12.959 -5.743 1.00 1.00 C +ATOM 1700 H5' A B 53 0.803 8.817 -2.143 1.00 1.00 H +ATOM 1701 H5'' A B 53 1.448 7.323 -2.856 1.00 1.00 H +ATOM 1702 H4' A B 53 0.520 8.753 -4.599 1.00 1.00 H +ATOM 1703 H3' A B 53 3.531 8.478 -4.590 1.00 1.00 H +ATOM 1704 H2' A B 53 3.699 9.945 -6.372 1.00 1.00 H +ATOM 1705 HO2' A B 53 2.472 9.417 -8.007 1.00 1.00 H +ATOM 1706 H1' A B 53 1.339 11.437 -5.873 1.00 1.00 H +ATOM 1707 H8 A B 53 3.742 11.380 -2.928 1.00 1.00 H +ATOM 1708 H61 A B 53 6.457 16.289 -5.555 1.00 1.00 H +ATOM 1709 H62 A B 53 6.365 15.284 -4.123 1.00 1.00 H +ATOM 1710 H2 A B 53 3.518 14.588 -8.484 1.00 1.00 H +ATOM 1711 P A B 54 3.333 6.404 -6.395 1.00 1.00 P +ATOM 1712 OP1 A B 54 2.706 5.085 -6.633 1.00 1.00 O +ATOM 1713 OP2 A B 54 4.538 6.504 -5.543 1.00 1.00 O +ATOM 1714 O5' A B 54 3.672 7.064 -7.826 1.00 1.00 O +ATOM 1715 C5' A B 54 2.837 6.807 -8.959 1.00 1.00 C +ATOM 1716 C4' A B 54 3.296 7.582 -10.192 1.00 1.00 C +ATOM 1717 O4' A B 54 3.378 8.977 -9.881 1.00 1.00 O +ATOM 1718 C3' A B 54 4.665 7.169 -10.723 1.00 1.00 C +ATOM 1719 O3' A B 54 4.512 6.154 -11.723 1.00 1.00 O +ATOM 1720 C2' A B 54 5.176 8.455 -11.352 1.00 1.00 C +ATOM 1721 O2' A B 54 4.729 8.596 -12.704 1.00 1.00 O +ATOM 1722 C1' A B 54 4.575 9.522 -10.449 1.00 1.00 C +ATOM 1723 N9 A B 54 5.456 9.919 -9.341 1.00 1.00 N +ATOM 1724 C8 A B 54 5.539 9.408 -8.070 1.00 1.00 C +ATOM 1725 N7 A B 54 6.436 9.991 -7.325 1.00 1.00 N +ATOM 1726 C5 A B 54 6.987 10.957 -8.162 1.00 1.00 C +ATOM 1727 C6 A B 54 7.997 11.914 -7.970 1.00 1.00 C +ATOM 1728 N6 A B 54 8.661 12.054 -6.822 1.00 1.00 N +ATOM 1729 N1 A B 54 8.294 12.714 -9.008 1.00 1.00 N +ATOM 1730 C2 A B 54 7.632 12.565 -10.150 1.00 1.00 C +ATOM 1731 N3 A B 54 6.670 11.707 -10.453 1.00 1.00 N +ATOM 1732 C4 A B 54 6.395 10.920 -9.392 1.00 1.00 C +ATOM 1733 H5' A B 54 1.814 7.097 -8.718 1.00 1.00 H +ATOM 1734 H5'' A B 54 2.859 5.740 -9.181 1.00 1.00 H +ATOM 1735 H4' A B 54 2.560 7.452 -10.983 1.00 1.00 H +ATOM 1736 H3' A B 54 5.318 6.843 -9.911 1.00 1.00 H +ATOM 1737 H2' A B 54 6.264 8.495 -11.299 1.00 1.00 H +ATOM 1738 HO2' A B 54 5.485 8.873 -13.227 1.00 1.00 H +ATOM 1739 H1' A B 54 4.329 10.407 -11.039 1.00 1.00 H +ATOM 1740 H8 A B 54 4.913 8.589 -7.716 1.00 1.00 H +ATOM 1741 H61 A B 54 9.375 12.756 -6.737 1.00 1.00 H +ATOM 1742 H62 A B 54 8.443 11.457 -6.036 1.00 1.00 H +ATOM 1743 H2 A B 54 7.924 13.245 -10.951 1.00 1.00 H +ATOM 1744 P G B 55 5.348 4.775 -11.635 1.00 1.00 P +ATOM 1745 OP1 G B 55 4.837 3.857 -12.677 1.00 1.00 O +ATOM 1746 OP2 G B 55 5.376 4.339 -10.222 1.00 1.00 O +ATOM 1747 O5' G B 55 6.840 5.221 -12.050 1.00 1.00 O +ATOM 1748 C5' G B 55 7.202 5.353 -13.428 1.00 1.00 C +ATOM 1749 C4' G B 55 8.604 5.939 -13.590 1.00 1.00 C +ATOM 1750 O4' G B 55 8.641 7.261 -13.066 1.00 1.00 O +ATOM 1751 C3' G B 55 9.703 5.172 -12.872 1.00 1.00 C +ATOM 1752 O3' G B 55 10.226 4.149 -13.727 1.00 1.00 O +ATOM 1753 C2' G B 55 10.761 6.232 -12.624 1.00 1.00 C +ATOM 1754 O2' G B 55 11.737 6.253 -13.671 1.00 1.00 O +ATOM 1755 C1' G B 55 9.964 7.531 -12.582 1.00 1.00 C +ATOM 1756 N9 G B 55 9.848 8.097 -11.229 1.00 1.00 N +ATOM 1757 C8 G B 55 8.837 7.961 -10.314 1.00 1.00 C +ATOM 1758 N7 G B 55 9.031 8.623 -9.208 1.00 1.00 N +ATOM 1759 C5 G B 55 10.261 9.245 -9.402 1.00 1.00 C +ATOM 1760 C6 G B 55 10.995 10.102 -8.536 1.00 1.00 C +ATOM 1761 O6 G B 55 10.693 10.489 -7.410 1.00 1.00 O +ATOM 1762 N1 G B 55 12.189 10.509 -9.116 1.00 1.00 N +ATOM 1763 C2 G B 55 12.627 10.139 -10.369 1.00 1.00 C +ATOM 1764 N2 G B 55 13.805 10.629 -10.750 1.00 1.00 N +ATOM 1765 N3 G B 55 11.938 9.334 -11.186 1.00 1.00 N +ATOM 1766 C4 G B 55 10.769 8.927 -10.637 1.00 1.00 C +ATOM 1767 H5' G B 55 6.485 6.008 -13.921 1.00 1.00 H +ATOM 1768 H5'' G B 55 7.170 4.372 -13.901 1.00 1.00 H +ATOM 1769 H4' G B 55 8.843 5.985 -14.650 1.00 1.00 H +ATOM 1770 H3' G B 55 9.338 4.758 -11.929 1.00 1.00 H +ATOM 1771 H2' G B 55 11.234 6.067 -11.657 1.00 1.00 H +ATOM 1772 HO2' G B 55 12.428 6.865 -13.406 1.00 1.00 H +ATOM 1773 H1' G B 55 10.439 8.265 -13.232 1.00 1.00 H +ATOM 1774 H8 G B 55 7.952 7.350 -10.492 1.00 1.00 H +ATOM 1775 H1 G B 55 12.767 11.123 -8.559 1.00 1.00 H +ATOM 1776 H21 G B 55 14.322 11.237 -10.132 1.00 1.00 H +ATOM 1777 H22 G B 55 14.180 10.395 -11.658 1.00 1.00 H +ATOM 1778 P A B 56 11.110 2.943 -13.125 1.00 1.00 P +ATOM 1779 OP1 A B 56 11.135 1.846 -14.119 1.00 1.00 O +ATOM 1780 OP2 A B 56 10.650 2.674 -11.745 1.00 1.00 O +ATOM 1781 O5' A B 56 12.587 3.585 -13.047 1.00 1.00 O +ATOM 1782 C5' A B 56 13.276 3.986 -14.235 1.00 1.00 C +ATOM 1783 C4' A B 56 14.535 4.791 -13.915 1.00 1.00 C +ATOM 1784 O4' A B 56 14.177 6.005 -13.255 1.00 1.00 O +ATOM 1785 C3' A B 56 15.526 4.076 -13.008 1.00 1.00 C +ATOM 1786 O3' A B 56 16.467 3.344 -13.804 1.00 1.00 O +ATOM 1787 C2' A B 56 16.224 5.222 -12.292 1.00 1.00 C +ATOM 1788 O2' A B 56 17.382 5.660 -13.011 1.00 1.00 O +ATOM 1789 C1' A B 56 15.151 6.308 -12.247 1.00 1.00 C +ATOM 1790 N9 A B 56 14.446 6.385 -10.959 1.00 1.00 N +ATOM 1791 C8 A B 56 13.431 5.599 -10.479 1.00 1.00 C +ATOM 1792 N7 A B 56 13.026 5.931 -9.284 1.00 1.00 N +ATOM 1793 C5 A B 56 13.831 7.015 -8.950 1.00 1.00 C +ATOM 1794 C6 A B 56 13.902 7.827 -7.805 1.00 1.00 C +ATOM 1795 N6 A B 56 13.116 7.659 -6.742 1.00 1.00 N +ATOM 1796 N1 A B 56 14.815 8.814 -7.805 1.00 1.00 N +ATOM 1797 C2 A B 56 15.596 8.974 -8.867 1.00 1.00 C +ATOM 1798 N3 A B 56 15.625 8.281 -9.995 1.00 1.00 N +ATOM 1799 C4 A B 56 14.698 7.300 -9.965 1.00 1.00 C +ATOM 1800 H5' A B 56 12.610 4.599 -14.843 1.00 1.00 H +ATOM 1801 H5'' A B 56 13.557 3.098 -14.801 1.00 1.00 H +ATOM 1802 H4' A B 56 15.035 5.045 -14.847 1.00 1.00 H +ATOM 1803 H3' A B 56 15.010 3.427 -12.297 1.00 1.00 H +ATOM 1804 H2' A B 56 16.490 4.923 -11.276 1.00 1.00 H +ATOM 1805 HO2' A B 56 17.345 5.261 -13.883 1.00 1.00 H +ATOM 1806 H1' A B 56 15.604 7.277 -12.460 1.00 1.00 H +ATOM 1807 H8 A B 56 13.002 4.770 -11.044 1.00 1.00 H +ATOM 1808 H61 A B 56 13.209 8.278 -5.939 1.00 1.00 H +ATOM 1809 H62 A B 56 12.427 6.921 -6.733 1.00 1.00 H +ATOM 1810 H2 A B 56 16.314 9.791 -8.800 1.00 1.00 H +ATOM 1811 P A B 57 17.002 1.893 -13.341 1.00 1.00 P +ATOM 1812 OP1 A B 57 17.940 1.400 -14.373 1.00 1.00 O +ATOM 1813 OP2 A B 57 15.834 1.070 -12.956 1.00 1.00 O +ATOM 1814 O5' A B 57 17.846 2.222 -12.009 1.00 1.00 O +ATOM 1815 C5' A B 57 19.191 2.702 -12.093 1.00 1.00 C +ATOM 1816 C4' A B 57 19.736 3.072 -10.717 1.00 1.00 C +ATOM 1817 O4' A B 57 18.991 4.154 -10.177 1.00 1.00 O +ATOM 1818 C3' A B 57 19.661 1.957 -9.688 1.00 1.00 C +ATOM 1819 O3' A B 57 20.848 1.156 -9.738 1.00 1.00 O +ATOM 1820 C2' A B 57 19.585 2.704 -8.368 1.00 1.00 C +ATOM 1821 O2' A B 57 20.879 2.868 -7.779 1.00 1.00 O +ATOM 1822 C1' A B 57 18.964 4.046 -8.746 1.00 1.00 C +ATOM 1823 N9 A B 57 17.559 4.181 -8.326 1.00 1.00 N +ATOM 1824 C8 A B 57 16.431 3.719 -8.954 1.00 1.00 C +ATOM 1825 N7 A B 57 15.323 4.011 -8.331 1.00 1.00 N +ATOM 1826 C5 A B 57 15.748 4.716 -7.209 1.00 1.00 C +ATOM 1827 C6 A B 57 15.053 5.305 -6.139 1.00 1.00 C +ATOM 1828 N6 A B 57 13.724 5.275 -6.025 1.00 1.00 N +ATOM 1829 N1 A B 57 15.783 5.924 -5.197 1.00 1.00 N +ATOM 1830 C2 A B 57 17.106 5.951 -5.316 1.00 1.00 C +ATOM 1831 N3 A B 57 17.870 5.438 -6.267 1.00 1.00 N +ATOM 1832 C4 A B 57 17.109 4.824 -7.198 1.00 1.00 C +ATOM 1833 H5' A B 57 19.215 3.584 -12.733 1.00 1.00 H +ATOM 1834 H5'' A B 57 19.821 1.927 -12.531 1.00 1.00 H +ATOM 1835 H4' A B 57 20.772 3.389 -10.821 1.00 1.00 H +ATOM 1836 H3' A B 57 18.765 1.350 -9.841 1.00 1.00 H +ATOM 1837 H2' A B 57 18.919 2.177 -7.693 1.00 1.00 H +ATOM 1838 HO2' A B 57 20.878 2.386 -6.949 1.00 1.00 H +ATOM 1839 H1' A B 57 19.548 4.855 -8.311 1.00 1.00 H +ATOM 1840 H8 A B 57 16.458 3.158 -9.889 1.00 1.00 H +ATOM 1841 H61 A B 57 13.278 5.715 -5.236 1.00 1.00 H +ATOM 1842 H62 A B 57 13.168 4.812 -6.729 1.00 1.00 H +ATOM 1843 H2 A B 57 17.636 6.469 -4.516 1.00 1.00 H +ATOM 1844 P C B 58 20.854 -0.344 -9.141 1.00 1.00 P +ATOM 1845 OP1 C B 58 22.128 -0.991 -9.528 1.00 1.00 O +ATOM 1846 OP2 C B 58 19.568 -0.985 -9.492 1.00 1.00 O +ATOM 1847 O5' C B 58 20.874 -0.105 -7.546 1.00 1.00 O +ATOM 1848 C5' C B 58 22.089 0.254 -6.876 1.00 1.00 C +ATOM 1849 C4' C B 58 21.863 0.491 -5.381 1.00 1.00 C +ATOM 1850 O4' C B 58 20.982 1.589 -5.196 1.00 1.00 O +ATOM 1851 C3' C B 58 21.236 -0.673 -4.639 1.00 1.00 C +ATOM 1852 O3' C B 58 22.258 -1.565 -4.177 1.00 1.00 O +ATOM 1853 C2' C B 58 20.550 0.001 -3.458 1.00 1.00 C +ATOM 1854 O2' C B 58 21.408 0.058 -2.316 1.00 1.00 O +ATOM 1855 C1' C B 58 20.227 1.404 -3.986 1.00 1.00 C +ATOM 1856 N1 C B 58 18.805 1.592 -4.340 1.00 1.00 N +ATOM 1857 C2 C B 58 17.994 2.293 -3.462 1.00 1.00 C +ATOM 1858 O2 C B 58 18.461 2.749 -2.420 1.00 1.00 O +ATOM 1859 N3 C B 58 16.682 2.460 -3.790 1.00 1.00 N +ATOM 1860 C4 C B 58 16.189 1.960 -4.932 1.00 1.00 C +ATOM 1861 N4 C B 58 14.900 2.138 -5.222 1.00 1.00 N +ATOM 1862 C5 C B 58 17.025 1.238 -5.840 1.00 1.00 C +ATOM 1863 C6 C B 58 18.320 1.078 -5.507 1.00 1.00 C +ATOM 1864 H5' C B 58 22.484 1.165 -7.324 1.00 1.00 H +ATOM 1865 H5'' C B 58 22.815 -0.548 -7.003 1.00 1.00 H +ATOM 1866 H4' C B 58 22.816 0.737 -4.917 1.00 1.00 H +ATOM 1867 H3' C B 58 20.509 -1.190 -5.269 1.00 1.00 H +ATOM 1868 H2' C B 58 19.625 -0.524 -3.221 1.00 1.00 H +ATOM 1869 HO2' C B 58 20.847 0.139 -1.542 1.00 1.00 H +ATOM 1870 H1' C B 58 20.524 2.146 -3.251 1.00 1.00 H +ATOM 1871 H41 C B 58 14.306 2.647 -4.588 1.00 1.00 H +ATOM 1872 H42 C B 58 14.520 1.766 -6.081 1.00 1.00 H +ATOM 1873 H5 C B 58 16.629 0.833 -6.772 1.00 1.00 H +ATOM 1874 H6 C B 58 18.987 0.535 -6.176 1.00 1.00 H +ATOM 1875 P C B 59 21.913 -3.104 -3.843 1.00 1.00 P +ATOM 1876 OP1 C B 59 23.136 -3.751 -3.318 1.00 1.00 O +ATOM 1877 OP2 C B 59 21.212 -3.686 -5.009 1.00 1.00 O +ATOM 1878 O5' C B 59 20.858 -2.964 -2.635 1.00 1.00 O +ATOM 1879 C5' C B 59 21.270 -2.426 -1.376 1.00 1.00 C +ATOM 1880 C4' C B 59 20.085 -1.900 -0.572 1.00 1.00 C +ATOM 1881 O4' C B 59 19.330 -1.003 -1.369 1.00 1.00 O +ATOM 1882 C3' C B 59 19.109 -2.962 -0.099 1.00 1.00 C +ATOM 1883 O3' C B 59 19.499 -3.422 1.200 1.00 1.00 O +ATOM 1884 C2' C B 59 17.788 -2.212 0.003 1.00 1.00 C +ATOM 1885 O2' C B 59 17.522 -1.804 1.350 1.00 1.00 O +ATOM 1886 C1' C B 59 17.971 -1.004 -0.921 1.00 1.00 C +ATOM 1887 N1 C B 59 17.094 -1.013 -2.114 1.00 1.00 N +ATOM 1888 C2 C B 59 15.956 -0.221 -2.070 1.00 1.00 C +ATOM 1889 O2 C B 59 15.711 0.446 -1.069 1.00 1.00 O +ATOM 1890 N3 C B 59 15.134 -0.213 -3.154 1.00 1.00 N +ATOM 1891 C4 C B 59 15.413 -0.950 -4.236 1.00 1.00 C +ATOM 1892 N4 C B 59 14.585 -0.918 -5.280 1.00 1.00 N +ATOM 1893 C5 C B 59 16.585 -1.770 -4.287 1.00 1.00 C +ATOM 1894 C6 C B 59 17.393 -1.771 -3.209 1.00 1.00 C +ATOM 1895 H5' C B 59 21.971 -1.610 -1.554 1.00 1.00 H +ATOM 1896 H5'' C B 59 21.770 -3.206 -0.803 1.00 1.00 H +ATOM 1897 H4' C B 59 20.460 -1.355 0.293 1.00 1.00 H +ATOM 1898 H3' C B 59 19.043 -3.783 -0.813 1.00 1.00 H +ATOM 1899 H2' C B 59 16.983 -2.845 -0.375 1.00 1.00 H +ATOM 1900 HO2' C B 59 17.650 -0.854 1.392 1.00 1.00 H +ATOM 1901 H1' C B 59 17.791 -0.093 -0.348 1.00 1.00 H +ATOM 1902 H41 C B 59 13.761 -0.342 -5.249 1.00 1.00 H +ATOM 1903 H42 C B 59 14.786 -1.470 -6.101 1.00 1.00 H +ATOM 1904 H5 C B 59 16.817 -2.369 -5.167 1.00 1.00 H +ATOM 1905 H6 C B 59 18.295 -2.385 -3.212 1.00 1.00 H +ATOM 1906 P G B 60 18.766 -4.688 1.874 1.00 1.00 P +ATOM 1907 OP1 G B 60 19.661 -5.239 2.918 1.00 1.00 O +ATOM 1908 OP2 G B 60 18.269 -5.566 0.792 1.00 1.00 O +ATOM 1909 O5' G B 60 17.493 -4.019 2.604 1.00 1.00 O +ATOM 1910 C5' G B 60 17.664 -3.166 3.742 1.00 1.00 C +ATOM 1911 C4' G B 60 16.329 -2.859 4.420 1.00 1.00 C +ATOM 1912 O4' G B 60 15.594 -1.896 3.667 1.00 1.00 O +ATOM 1913 C3' G B 60 15.425 -4.069 4.577 1.00 1.00 C +ATOM 1914 O3' G B 60 15.678 -4.703 5.833 1.00 1.00 O +ATOM 1915 C2' G B 60 14.024 -3.479 4.563 1.00 1.00 C +ATOM 1916 O2' G B 60 13.550 -3.221 5.889 1.00 1.00 O +ATOM 1917 C1' G B 60 14.190 -2.184 3.771 1.00 1.00 C +ATOM 1918 N9 G B 60 13.660 -2.261 2.403 1.00 1.00 N +ATOM 1919 C8 G B 60 14.355 -2.379 1.228 1.00 1.00 C +ATOM 1920 N7 G B 60 13.597 -2.436 0.168 1.00 1.00 N +ATOM 1921 C5 G B 60 12.303 -2.349 0.676 1.00 1.00 C +ATOM 1922 C6 G B 60 11.055 -2.359 -0.005 1.00 1.00 C +ATOM 1923 O6 G B 60 10.845 -2.448 -1.213 1.00 1.00 O +ATOM 1924 N1 G B 60 9.992 -2.251 0.880 1.00 1.00 N +ATOM 1925 C2 G B 60 10.110 -2.147 2.250 1.00 1.00 C +ATOM 1926 N2 G B 60 8.970 -2.056 2.934 1.00 1.00 N +ATOM 1927 N3 G B 60 11.282 -2.137 2.893 1.00 1.00 N +ATOM 1928 C4 G B 60 12.332 -2.241 2.044 1.00 1.00 C +ATOM 1929 H5' G B 60 18.122 -2.231 3.420 1.00 1.00 H +ATOM 1930 H5'' G B 60 18.323 -3.657 4.459 1.00 1.00 H +ATOM 1931 H4' G B 60 16.527 -2.440 5.405 1.00 1.00 H +ATOM 1932 H3' G B 60 15.559 -4.764 3.746 1.00 1.00 H +ATOM 1933 H2' G B 60 13.344 -4.151 4.034 1.00 1.00 H +ATOM 1934 HO2' G B 60 12.927 -2.492 5.831 1.00 1.00 H +ATOM 1935 H1' G B 60 13.694 -1.372 4.300 1.00 1.00 H +ATOM 1936 H8 G B 60 15.443 -2.423 1.182 1.00 1.00 H +ATOM 1937 H1 G B 60 9.069 -2.251 0.469 1.00 1.00 H +ATOM 1938 H21 G B 60 8.085 -2.063 2.446 1.00 1.00 H +ATOM 1939 H22 G B 60 8.990 -1.977 3.941 1.00 1.00 H +ATOM 1940 P G B 61 15.286 -6.247 6.060 1.00 1.00 P +ATOM 1941 OP1 G B 61 15.760 -6.654 7.401 1.00 1.00 O +ATOM 1942 OP2 G B 61 15.704 -7.012 4.864 1.00 1.00 O +ATOM 1943 O5' G B 61 13.677 -6.199 6.088 1.00 1.00 O +ATOM 1944 C5' G B 61 12.990 -5.476 7.114 1.00 1.00 C +ATOM 1945 C4' G B 61 11.475 -5.550 6.936 1.00 1.00 C +ATOM 1946 O4' G B 61 11.093 -4.900 5.728 1.00 1.00 O +ATOM 1947 C3' G B 61 10.923 -6.963 6.856 1.00 1.00 C +ATOM 1948 O3' G B 61 10.580 -7.420 8.171 1.00 1.00 O +ATOM 1949 C2' G B 61 9.670 -6.812 6.005 1.00 1.00 C +ATOM 1950 O2' G B 61 8.495 -6.691 6.812 1.00 1.00 O +ATOM 1951 C1' G B 61 9.924 -5.541 5.199 1.00 1.00 C +ATOM 1952 N9 G B 61 10.162 -5.791 3.767 1.00 1.00 N +ATOM 1953 C8 G B 61 11.339 -6.087 3.132 1.00 1.00 C +ATOM 1954 N7 G B 61 11.220 -6.249 1.844 1.00 1.00 N +ATOM 1955 C5 G B 61 9.864 -6.046 1.604 1.00 1.00 C +ATOM 1956 C6 G B 61 9.139 -6.094 0.381 1.00 1.00 C +ATOM 1957 O6 G B 61 9.561 -6.331 -0.749 1.00 1.00 O +ATOM 1958 N1 G B 61 7.790 -5.831 0.579 1.00 1.00 N +ATOM 1959 C2 G B 61 7.209 -5.555 1.797 1.00 1.00 C +ATOM 1960 N2 G B 61 5.895 -5.328 1.784 1.00 1.00 N +ATOM 1961 N3 G B 61 7.887 -5.510 2.949 1.00 1.00 N +ATOM 1962 C4 G B 61 9.207 -5.765 2.776 1.00 1.00 C +ATOM 1963 H5' G B 61 13.301 -4.432 7.081 1.00 1.00 H +ATOM 1964 H5'' G B 61 13.255 -5.897 8.084 1.00 1.00 H +ATOM 1965 H4' G B 61 11.000 -5.034 7.769 1.00 1.00 H +ATOM 1966 H3' G B 61 11.639 -7.632 6.377 1.00 1.00 H +ATOM 1967 H2' G B 61 9.584 -7.659 5.325 1.00 1.00 H +ATOM 1968 HO2' G B 61 7.742 -6.676 6.217 1.00 1.00 H +ATOM 1969 H1' G B 61 9.069 -4.873 5.306 1.00 1.00 H +ATOM 1970 H8 G B 61 12.290 -6.175 3.657 1.00 1.00 H +ATOM 1971 H1 G B 61 7.209 -5.848 -0.248 1.00 1.00 H +ATOM 1972 H21 G B 61 5.385 -5.362 0.913 1.00 1.00 H +ATOM 1973 H22 G B 61 5.410 -5.120 2.645 1.00 1.00 H +ATOM 1974 P G B 62 10.359 -8.989 8.473 1.00 1.00 P +ATOM 1975 OP1 G B 62 10.332 -9.180 9.940 1.00 1.00 O +ATOM 1976 OP2 G B 62 11.317 -9.760 7.648 1.00 1.00 O +ATOM 1977 O5' G B 62 8.876 -9.258 7.901 1.00 1.00 O +ATOM 1978 C5' G B 62 7.754 -8.534 8.418 1.00 1.00 C +ATOM 1979 C4' G B 62 6.494 -8.778 7.590 1.00 1.00 C +ATOM 1980 O4' G B 62 6.694 -8.301 6.264 1.00 1.00 O +ATOM 1981 C3' G B 62 6.093 -10.241 7.474 1.00 1.00 C +ATOM 1982 O3' G B 62 5.156 -10.560 8.510 1.00 1.00 O +ATOM 1983 C2' G B 62 5.411 -10.324 6.115 1.00 1.00 C +ATOM 1984 O2' G B 62 3.989 -10.211 6.239 1.00 1.00 O +ATOM 1985 C1' G B 62 5.998 -9.143 5.336 1.00 1.00 C +ATOM 1986 N9 G B 62 6.961 -9.538 4.298 1.00 1.00 N +ATOM 1987 C8 G B 62 8.301 -9.799 4.422 1.00 1.00 C +ATOM 1988 N7 G B 62 8.885 -10.116 3.300 1.00 1.00 N +ATOM 1989 C5 G B 62 7.859 -10.060 2.361 1.00 1.00 C +ATOM 1990 C6 G B 62 7.892 -10.306 0.960 1.00 1.00 C +ATOM 1991 O6 G B 62 8.852 -10.629 0.264 1.00 1.00 O +ATOM 1992 N1 G B 62 6.640 -10.140 0.385 1.00 1.00 N +ATOM 1993 C2 G B 62 5.496 -9.781 1.068 1.00 1.00 C +ATOM 1994 N2 G B 62 4.385 -9.670 0.341 1.00 1.00 N +ATOM 1995 N3 G B 62 5.464 -9.550 2.384 1.00 1.00 N +ATOM 1996 C4 G B 62 6.677 -9.707 2.963 1.00 1.00 C +ATOM 1997 H5' G B 62 7.985 -7.468 8.409 1.00 1.00 H +ATOM 1998 H5'' G B 62 7.572 -8.849 9.445 1.00 1.00 H +ATOM 1999 H4' G B 62 5.670 -8.221 8.033 1.00 1.00 H +ATOM 2000 H3' G B 62 6.970 -10.889 7.514 1.00 1.00 H +ATOM 2001 H2' G B 62 5.680 -11.262 5.624 1.00 1.00 H +ATOM 2002 HO2' G B 62 3.799 -9.965 7.147 1.00 1.00 H +ATOM 2003 H1' G B 62 5.190 -8.577 4.871 1.00 1.00 H +ATOM 2004 H8 G B 62 8.830 -9.747 5.374 1.00 1.00 H +ATOM 2005 H1 G B 62 6.584 -10.299 -0.611 1.00 1.00 H +ATOM 2006 H21 G B 62 4.412 -9.846 -0.654 1.00 1.00 H +ATOM 2007 H22 G B 62 3.517 -9.411 0.784 1.00 1.00 H +ATOM 2008 P G B 63 5.113 -12.031 9.166 1.00 1.00 P +ATOM 2009 OP1 G B 63 4.151 -12.008 10.289 1.00 1.00 O +ATOM 2010 OP2 G B 63 6.506 -12.476 9.399 1.00 1.00 O +ATOM 2011 O5' G B 63 4.487 -12.933 7.987 1.00 1.00 O +ATOM 2012 C5' G B 63 4.829 -14.319 7.882 1.00 1.00 C +ATOM 2013 C4' G B 63 4.406 -14.906 6.534 1.00 1.00 C +ATOM 2014 O4' G B 63 4.576 -13.929 5.502 1.00 1.00 O +ATOM 2015 C3' G B 63 5.191 -16.147 6.122 1.00 1.00 C +ATOM 2016 O3' G B 63 4.441 -17.317 6.459 1.00 1.00 O +ATOM 2017 C2' G B 63 5.309 -16.022 4.611 1.00 1.00 C +ATOM 2018 O2' G B 63 4.238 -16.703 3.947 1.00 1.00 O +ATOM 2019 C1' G B 63 5.240 -14.517 4.374 1.00 1.00 C +ATOM 2020 N9 G B 63 6.557 -13.868 4.262 1.00 1.00 N +ATOM 2021 C8 G B 63 7.352 -13.380 5.266 1.00 1.00 C +ATOM 2022 N7 G B 63 8.467 -12.850 4.849 1.00 1.00 N +ATOM 2023 C5 G B 63 8.411 -12.995 3.468 1.00 1.00 C +ATOM 2024 C6 G B 63 9.350 -12.605 2.474 1.00 1.00 C +ATOM 2025 O6 G B 63 10.435 -12.047 2.625 1.00 1.00 O +ATOM 2026 N1 G B 63 8.909 -12.934 1.200 1.00 1.00 N +ATOM 2027 C2 G B 63 7.716 -13.561 0.913 1.00 1.00 C +ATOM 2028 N2 G B 63 7.469 -13.792 -0.376 1.00 1.00 N +ATOM 2029 N3 G B 63 6.830 -13.931 1.845 1.00 1.00 N +ATOM 2030 C4 G B 63 7.245 -13.617 3.096 1.00 1.00 C +ATOM 2031 H5' G B 63 4.330 -14.867 8.680 1.00 1.00 H +ATOM 2032 H5'' G B 63 5.906 -14.425 7.998 1.00 1.00 H +ATOM 2033 H4' G B 63 3.351 -15.165 6.587 1.00 1.00 H +ATOM 2034 H3' G B 63 6.179 -16.161 6.588 1.00 1.00 H +ATOM 2035 H2' G B 63 6.276 -16.406 4.280 1.00 1.00 H +ATOM 2036 HO2' G B 63 3.864 -17.326 4.573 1.00 1.00 H +ATOM 2037 H1' G B 63 4.664 -14.317 3.471 1.00 1.00 H +ATOM 2038 H8 G B 63 7.076 -13.429 6.319 1.00 1.00 H +ATOM 2039 H1 G B 63 9.525 -12.687 0.439 1.00 1.00 H +ATOM 2040 H21 G B 63 8.140 -13.511 -1.077 1.00 1.00 H +ATOM 2041 H22 G B 63 6.615 -14.246 -0.649 1.00 1.00 H +ATOM 2042 P A B 64 5.148 -18.559 7.201 1.00 1.00 P +ATOM 2043 OP1 A B 64 4.091 -19.477 7.679 1.00 1.00 O +ATOM 2044 OP2 A B 64 6.145 -18.023 8.155 1.00 1.00 O +ATOM 2045 O5' A B 64 5.940 -19.284 6.002 1.00 1.00 O +ATOM 2046 C5' A B 64 7.107 -20.064 6.270 1.00 1.00 C +ATOM 2047 C4' A B 64 7.531 -20.873 5.046 1.00 1.00 C +ATOM 2048 O4' A B 64 6.543 -21.872 4.768 1.00 1.00 O +ATOM 2049 C3' A B 64 7.704 -20.028 3.789 1.00 1.00 C +ATOM 2050 O3' A B 64 9.100 -19.826 3.543 1.00 1.00 O +ATOM 2051 C2' A B 64 7.100 -20.873 2.679 1.00 1.00 C +ATOM 2052 O2' A B 64 8.098 -21.655 2.013 1.00 1.00 O +ATOM 2053 C1' A B 64 6.102 -21.756 3.412 1.00 1.00 C +ATOM 2054 N9 A B 64 4.729 -21.217 3.438 1.00 1.00 N +ATOM 2055 C8 A B 64 4.079 -20.587 4.467 1.00 1.00 C +ATOM 2056 N7 A B 64 2.861 -20.220 4.176 1.00 1.00 N +ATOM 2057 C5 A B 64 2.693 -20.639 2.860 1.00 1.00 C +ATOM 2058 C6 A B 64 1.613 -20.547 1.967 1.00 1.00 C +ATOM 2059 N6 A B 64 0.451 -19.974 2.285 1.00 1.00 N +ATOM 2060 N1 A B 64 1.782 -21.066 0.740 1.00 1.00 N +ATOM 2061 C2 A B 64 2.942 -21.632 0.430 1.00 1.00 C +ATOM 2062 N3 A B 64 4.027 -21.778 1.177 1.00 1.00 N +ATOM 2063 C4 A B 64 3.826 -21.248 2.402 1.00 1.00 C +ATOM 2064 H5' A B 64 6.901 -20.746 7.094 1.00 1.00 H +ATOM 2065 H5'' A B 64 7.922 -19.398 6.553 1.00 1.00 H +ATOM 2066 H4' A B 64 8.473 -21.372 5.266 1.00 1.00 H +ATOM 2067 H3' A B 64 7.177 -19.076 3.884 1.00 1.00 H +ATOM 2068 H2' A B 64 6.574 -20.231 1.970 1.00 1.00 H +ATOM 2069 HO2' A B 64 8.455 -21.117 1.303 1.00 1.00 H +ATOM 2070 H1' A B 64 6.088 -22.744 2.952 1.00 1.00 H +ATOM 2071 H8 A B 64 4.536 -20.408 5.439 1.00 1.00 H +ATOM 2072 H61 A B 64 -0.295 -19.935 1.605 1.00 1.00 H +ATOM 2073 H62 A B 64 0.316 -19.582 3.205 1.00 1.00 H +ATOM 2074 H2 A B 64 3.011 -22.033 -0.581 1.00 1.00 H +ATOM 2075 P A B 65 9.623 -18.483 2.823 1.00 1.00 P +ATOM 2076 OP1 A B 65 10.907 -18.092 3.448 1.00 1.00 O +ATOM 2077 OP2 A B 65 8.503 -17.517 2.773 1.00 1.00 O +ATOM 2078 O5' A B 65 9.926 -18.980 1.324 1.00 1.00 O +ATOM 2079 C5' A B 65 9.319 -18.327 0.208 1.00 1.00 C +ATOM 2080 C4' A B 65 8.480 -19.299 -0.614 1.00 1.00 C +ATOM 2081 O4' A B 65 7.418 -19.809 0.196 1.00 1.00 O +ATOM 2082 C3' A B 65 7.855 -18.671 -1.853 1.00 1.00 C +ATOM 2083 O3' A B 65 8.637 -19.000 -3.006 1.00 1.00 O +ATOM 2084 C2' A B 65 6.492 -19.336 -1.953 1.00 1.00 C +ATOM 2085 O2' A B 65 6.540 -20.497 -2.790 1.00 1.00 O +ATOM 2086 C1' A B 65 6.179 -19.708 -0.510 1.00 1.00 C +ATOM 2087 N9 A B 65 5.344 -18.718 0.195 1.00 1.00 N +ATOM 2088 C8 A B 65 5.666 -17.913 1.257 1.00 1.00 C +ATOM 2089 N7 A B 65 4.686 -17.144 1.650 1.00 1.00 N +ATOM 2090 C5 A B 65 3.644 -17.466 0.783 1.00 1.00 C +ATOM 2091 C6 A B 65 2.323 -17.000 0.668 1.00 1.00 C +ATOM 2092 N6 A B 65 1.806 -16.065 1.467 1.00 1.00 N +ATOM 2093 N1 A B 65 1.563 -17.536 -0.301 1.00 1.00 N +ATOM 2094 C2 A B 65 2.083 -18.465 -1.094 1.00 1.00 C +ATOM 2095 N3 A B 65 3.301 -18.981 -1.087 1.00 1.00 N +ATOM 2096 C4 A B 65 4.039 -18.425 -0.104 1.00 1.00 C +ATOM 2097 H5' A B 65 10.097 -17.902 -0.425 1.00 1.00 H +ATOM 2098 H5'' A B 65 8.677 -17.523 0.572 1.00 1.00 H +ATOM 2099 H4' A B 65 9.109 -20.131 -0.922 1.00 1.00 H +ATOM 2100 H3' A B 65 7.757 -17.592 -1.731 1.00 1.00 H +ATOM 2101 H2' A B 65 5.754 -18.620 -2.322 1.00 1.00 H +ATOM 2102 HO2' A B 65 7.088 -20.280 -3.547 1.00 1.00 H +ATOM 2103 H1' A B 65 5.675 -20.673 -0.488 1.00 1.00 H +ATOM 2104 H8 A B 65 6.649 -17.913 1.730 1.00 1.00 H +ATOM 2105 H61 A B 65 0.851 -15.767 1.342 1.00 1.00 H +ATOM 2106 H62 A B 65 2.371 -15.658 2.199 1.00 1.00 H +ATOM 2107 H2 A B 65 1.412 -18.858 -1.858 1.00 1.00 H +ATOM 2108 P A B 66 9.003 -17.876 -4.101 1.00 1.00 P +ATOM 2109 OP1 A B 66 9.739 -18.530 -5.206 1.00 1.00 O +ATOM 2110 OP2 A B 66 9.607 -16.722 -3.397 1.00 1.00 O +ATOM 2111 O5' A B 66 7.559 -17.425 -4.655 1.00 1.00 O +ATOM 2112 C5' A B 66 6.898 -18.176 -5.679 1.00 1.00 C +ATOM 2113 C4' A B 66 5.494 -17.637 -5.948 1.00 1.00 C +ATOM 2114 O4' A B 66 4.677 -17.828 -4.793 1.00 1.00 O +ATOM 2115 C3' A B 66 5.454 -16.152 -6.283 1.00 1.00 C +ATOM 2116 O3' A B 66 5.470 -15.976 -7.705 1.00 1.00 O +ATOM 2117 C2' A B 66 4.115 -15.697 -5.723 1.00 1.00 C +ATOM 2118 O2' A B 66 3.080 -15.784 -6.709 1.00 1.00 O +ATOM 2119 C1' A B 66 3.870 -16.666 -4.571 1.00 1.00 C +ATOM 2120 N9 A B 66 4.239 -16.117 -3.255 1.00 1.00 N +ATOM 2121 C8 A B 66 5.475 -16.073 -2.662 1.00 1.00 C +ATOM 2122 N7 A B 66 5.477 -15.497 -1.491 1.00 1.00 N +ATOM 2123 C5 A B 66 4.148 -15.136 -1.295 1.00 1.00 C +ATOM 2124 C6 A B 66 3.488 -14.486 -0.240 1.00 1.00 C +ATOM 2125 N6 A B 66 4.109 -14.060 0.860 1.00 1.00 N +ATOM 2126 N1 A B 66 2.166 -14.290 -0.369 1.00 1.00 N +ATOM 2127 C2 A B 66 1.553 -14.710 -1.470 1.00 1.00 C +ATOM 2128 N3 A B 66 2.060 -15.328 -2.524 1.00 1.00 N +ATOM 2129 C4 A B 66 3.387 -15.511 -2.364 1.00 1.00 C +ATOM 2130 H5' A B 66 6.825 -19.217 -5.365 1.00 1.00 H +ATOM 2131 H5'' A B 66 7.483 -18.120 -6.597 1.00 1.00 H +ATOM 2132 H4' A B 66 5.057 -18.195 -6.774 1.00 1.00 H +ATOM 2133 H3' A B 66 6.279 -15.620 -5.804 1.00 1.00 H +ATOM 2134 H2' A B 66 4.198 -14.680 -5.337 1.00 1.00 H +ATOM 2135 HO2' A B 66 3.324 -16.486 -7.316 1.00 1.00 H +ATOM 2136 H1' A B 66 2.820 -16.953 -4.557 1.00 1.00 H +ATOM 2137 H8 A B 66 6.373 -16.481 -3.126 1.00 1.00 H +ATOM 2138 H61 A B 66 3.583 -13.598 1.590 1.00 1.00 H +ATOM 2139 H62 A B 66 5.109 -14.203 0.971 1.00 1.00 H +ATOM 2140 H2 A B 66 0.481 -14.518 -1.510 1.00 1.00 H +ATOM 2141 P C B 67 6.141 -14.668 -8.370 1.00 1.00 P +ATOM 2142 OP1 C B 67 5.877 -14.706 -9.826 1.00 1.00 O +ATOM 2143 OP2 C B 67 7.532 -14.559 -7.877 1.00 1.00 O +ATOM 2144 O5' C B 67 5.286 -13.459 -7.735 1.00 1.00 O +ATOM 2145 C5' C B 67 3.893 -13.320 -8.023 1.00 1.00 C +ATOM 2146 C4' C B 67 3.196 -12.423 -7.004 1.00 1.00 C +ATOM 2147 O4' C B 67 3.472 -12.888 -5.683 1.00 1.00 O +ATOM 2148 C3' C B 67 3.631 -10.966 -7.049 1.00 1.00 C +ATOM 2149 O3' C B 67 2.770 -10.231 -7.924 1.00 1.00 O +ATOM 2150 C2' C B 67 3.432 -10.493 -5.621 1.00 1.00 C +ATOM 2151 O2' C B 67 2.126 -9.937 -5.431 1.00 1.00 O +ATOM 2152 C1' C B 67 3.620 -11.765 -4.800 1.00 1.00 C +ATOM 2153 N1 C B 67 4.946 -11.867 -4.167 1.00 1.00 N +ATOM 2154 C2 C B 67 5.118 -11.250 -2.938 1.00 1.00 C +ATOM 2155 O2 C B 67 4.181 -10.648 -2.415 1.00 1.00 O +ATOM 2156 N3 C B 67 6.338 -11.331 -2.339 1.00 1.00 N +ATOM 2157 C4 C B 67 7.348 -11.990 -2.922 1.00 1.00 C +ATOM 2158 N4 C B 67 8.530 -12.050 -2.308 1.00 1.00 N +ATOM 2159 C5 C B 67 7.176 -12.627 -4.191 1.00 1.00 C +ATOM 2160 C6 C B 67 5.964 -12.542 -4.775 1.00 1.00 C +ATOM 2161 H5' C B 67 3.426 -14.305 -8.008 1.00 1.00 H +ATOM 2162 H5'' C B 67 3.777 -12.888 -9.017 1.00 1.00 H +ATOM 2163 H4' C B 67 2.122 -12.475 -7.166 1.00 1.00 H +ATOM 2164 H3' C B 67 4.677 -10.878 -7.349 1.00 1.00 H +ATOM 2165 H2' C B 67 4.204 -9.766 -5.358 1.00 1.00 H +ATOM 2166 HO2' C B 67 1.490 -10.641 -5.582 1.00 1.00 H +ATOM 2167 H1' C B 67 2.852 -11.812 -4.029 1.00 1.00 H +ATOM 2168 H41 C B 67 8.656 -11.601 -1.414 1.00 1.00 H +ATOM 2169 H42 C B 67 9.299 -12.543 -2.739 1.00 1.00 H +ATOM 2170 H5 C B 67 7.996 -13.164 -4.669 1.00 1.00 H +ATOM 2171 H6 C B 67 5.796 -13.018 -5.742 1.00 1.00 H +ATOM 2172 P U B 68 3.253 -8.837 -8.569 1.00 1.00 P +ATOM 2173 OP1 U B 68 2.177 -8.340 -9.455 1.00 1.00 O +ATOM 2174 OP2 U B 68 4.621 -9.021 -9.103 1.00 1.00 O +ATOM 2175 O5' U B 68 3.339 -7.866 -7.285 1.00 1.00 O +ATOM 2176 C5' U B 68 2.174 -7.587 -6.503 1.00 1.00 C +ATOM 2177 C4' U B 68 2.509 -6.751 -5.269 1.00 1.00 C +ATOM 2178 O4' U B 68 3.368 -7.481 -4.398 1.00 1.00 O +ATOM 2179 C3' U B 68 3.223 -5.447 -5.571 1.00 1.00 C +ATOM 2180 O3' U B 68 2.261 -4.404 -5.769 1.00 1.00 O +ATOM 2181 C2' U B 68 4.024 -5.177 -4.309 1.00 1.00 C +ATOM 2182 O2' U B 68 3.328 -4.283 -3.433 1.00 1.00 O +ATOM 2183 C1' U B 68 4.198 -6.558 -3.677 1.00 1.00 C +ATOM 2184 N1 U B 68 5.586 -7.066 -3.733 1.00 1.00 N +ATOM 2185 C2 U B 68 6.389 -6.868 -2.626 1.00 1.00 C +ATOM 2186 O2 U B 68 5.988 -6.285 -1.621 1.00 1.00 O +ATOM 2187 N3 U B 68 7.678 -7.365 -2.713 1.00 1.00 N +ATOM 2188 C4 U B 68 8.224 -8.032 -3.797 1.00 1.00 C +ATOM 2189 O4 U B 68 9.385 -8.432 -3.766 1.00 1.00 O +ATOM 2190 C5 U B 68 7.313 -8.194 -4.908 1.00 1.00 C +ATOM 2191 C6 U B 68 6.046 -7.716 -4.845 1.00 1.00 C +ATOM 2192 H5' U B 68 1.727 -8.529 -6.184 1.00 1.00 H +ATOM 2193 H5'' U B 68 1.456 -7.042 -7.116 1.00 1.00 H +ATOM 2194 H4' U B 68 1.587 -6.532 -4.734 1.00 1.00 H +ATOM 2195 H3' U B 68 3.880 -5.552 -6.436 1.00 1.00 H +ATOM 2196 H2' U B 68 4.998 -4.772 -4.576 1.00 1.00 H +ATOM 2197 HO2' U B 68 2.887 -4.819 -2.770 1.00 1.00 H +ATOM 2198 H1' U B 68 3.870 -6.519 -2.639 1.00 1.00 H +ATOM 2199 H3 U B 68 8.277 -7.226 -1.912 1.00 1.00 H +ATOM 2200 H5 U B 68 7.650 -8.708 -5.809 1.00 1.00 H +ATOM 2201 H6 U B 68 5.382 -7.851 -5.698 1.00 1.00 H +ATOM 2202 P U B 69 2.710 -2.977 -6.368 1.00 1.00 P +ATOM 2203 OP1 U B 69 1.509 -2.303 -6.910 1.00 1.00 O +ATOM 2204 OP2 U B 69 3.891 -3.188 -7.234 1.00 1.00 O +ATOM 2205 O5' U B 69 3.188 -2.177 -5.052 1.00 1.00 O +ATOM 2206 C5' U B 69 2.268 -1.895 -3.992 1.00 1.00 C +ATOM 2207 C4' U B 69 2.987 -1.384 -2.744 1.00 1.00 C +ATOM 2208 O4' U B 69 3.825 -2.405 -2.206 1.00 1.00 O +ATOM 2209 C3' U B 69 3.885 -0.184 -2.985 1.00 1.00 C +ATOM 2210 O3' U B 69 3.137 1.032 -2.825 1.00 1.00 O +ATOM 2211 C2' U B 69 4.939 -0.315 -1.895 1.00 1.00 C +ATOM 2212 O2' U B 69 4.585 0.408 -0.714 1.00 1.00 O +ATOM 2213 C1' U B 69 4.996 -1.807 -1.622 1.00 1.00 C +ATOM 2214 N1 U B 69 6.176 -2.445 -2.227 1.00 1.00 N +ATOM 2215 C2 U B 69 7.288 -2.662 -1.434 1.00 1.00 C +ATOM 2216 O2 U B 69 7.322 -2.328 -0.251 1.00 1.00 O +ATOM 2217 N3 U B 69 8.364 -3.275 -2.050 1.00 1.00 N +ATOM 2218 C4 U B 69 8.424 -3.683 -3.372 1.00 1.00 C +ATOM 2219 O4 U B 69 9.436 -4.221 -3.816 1.00 1.00 O +ATOM 2220 C5 U B 69 7.218 -3.417 -4.125 1.00 1.00 C +ATOM 2221 C6 U B 69 6.151 -2.820 -3.542 1.00 1.00 C +ATOM 2222 H5' U B 69 1.726 -2.808 -3.742 1.00 1.00 H +ATOM 2223 H5'' U B 69 1.556 -1.141 -4.330 1.00 1.00 H +ATOM 2224 H4' U B 69 2.243 -1.121 -1.994 1.00 1.00 H +ATOM 2225 H3' U B 69 4.344 -0.240 -3.975 1.00 1.00 H +ATOM 2226 H2' U B 69 5.902 0.010 -2.280 1.00 1.00 H +ATOM 2227 HO2' U B 69 5.348 0.392 -0.131 1.00 1.00 H +ATOM 2228 H1' U B 69 4.997 -1.983 -0.547 1.00 1.00 H +ATOM 2229 H3 U B 69 9.184 -3.438 -1.482 1.00 1.00 H +ATOM 2230 H5 U B 69 7.167 -3.700 -5.176 1.00 1.00 H +ATOM 2231 H6 U B 69 5.255 -2.634 -4.133 1.00 1.00 H +ATOM 2232 P G B 70 3.660 2.423 -3.463 1.00 1.00 P +ATOM 2233 OP1 G B 70 2.621 3.453 -3.247 1.00 1.00 O +ATOM 2234 OP2 G B 70 4.162 2.153 -4.828 1.00 1.00 O +ATOM 2235 O5' G B 70 4.917 2.774 -2.524 1.00 1.00 O +ATOM 2236 C5' G B 70 4.735 2.866 -1.113 1.00 1.00 C +ATOM 2237 C4' G B 70 6.046 2.661 -0.362 1.00 1.00 C +ATOM 2238 O4' G B 70 6.682 1.483 -0.851 1.00 1.00 O +ATOM 2239 C3' G B 70 7.061 3.780 -0.519 1.00 1.00 C +ATOM 2240 O3' G B 70 6.882 4.740 0.532 1.00 1.00 O +ATOM 2241 C2' G B 70 8.393 3.072 -0.331 1.00 1.00 C +ATOM 2242 O2' G B 70 8.853 3.184 1.022 1.00 1.00 O +ATOM 2243 C1' G B 70 8.095 1.621 -0.693 1.00 1.00 C +ATOM 2244 N9 G B 70 8.761 1.171 -1.926 1.00 1.00 N +ATOM 2245 C8 G B 70 8.266 1.063 -3.201 1.00 1.00 C +ATOM 2246 N7 G B 70 9.117 0.570 -4.058 1.00 1.00 N +ATOM 2247 C5 G B 70 10.260 0.338 -3.297 1.00 1.00 C +ATOM 2248 C6 G B 70 11.521 -0.192 -3.685 1.00 1.00 C +ATOM 2249 O6 G B 70 11.879 -0.575 -4.798 1.00 1.00 O +ATOM 2250 N1 G B 70 12.399 -0.255 -2.611 1.00 1.00 N +ATOM 2251 C2 G B 70 12.102 0.140 -1.324 1.00 1.00 C +ATOM 2252 N2 G B 70 13.076 0.010 -0.425 1.00 1.00 N +ATOM 2253 N3 G B 70 10.918 0.636 -0.959 1.00 1.00 N +ATOM 2254 C4 G B 70 10.051 0.707 -1.993 1.00 1.00 C +ATOM 2255 H5' G B 70 4.023 2.105 -0.797 1.00 1.00 H +ATOM 2256 H5'' G B 70 4.336 3.851 -0.867 1.00 1.00 H +ATOM 2257 H4' G B 70 5.832 2.521 0.694 1.00 1.00 H +ATOM 2258 H3' G B 70 6.995 4.243 -1.504 1.00 1.00 H +ATOM 2259 H2' G B 70 9.132 3.483 -1.023 1.00 1.00 H +ATOM 2260 HO2' G B 70 8.592 2.382 1.480 1.00 1.00 H +ATOM 2261 H1' G B 70 8.416 0.977 0.125 1.00 1.00 H +ATOM 2262 H8 G B 70 7.255 1.365 -3.474 1.00 1.00 H +ATOM 2263 H1 G B 70 13.318 -0.626 -2.809 1.00 1.00 H +ATOM 2264 H21 G B 70 13.974 -0.364 -0.702 1.00 1.00 H +ATOM 2265 H22 G B 70 12.917 0.284 0.535 1.00 1.00 H +ATOM 2266 P G B 71 7.566 6.199 0.449 1.00 1.00 P +ATOM 2267 OP1 G B 71 6.754 7.134 1.261 1.00 1.00 O +ATOM 2268 OP2 G B 71 7.836 6.505 -0.973 1.00 1.00 O +ATOM 2269 O5' G B 71 8.982 5.988 1.195 1.00 1.00 O +ATOM 2270 C5' G B 71 9.070 5.996 2.626 1.00 1.00 C +ATOM 2271 C4' G B 71 10.494 6.289 3.106 1.00 1.00 C +ATOM 2272 O4' G B 71 11.278 5.090 3.080 1.00 1.00 O +ATOM 2273 C3' G B 71 11.225 7.330 2.262 1.00 1.00 C +ATOM 2274 O3' G B 71 11.179 8.603 2.917 1.00 1.00 O +ATOM 2275 C2' G B 71 12.656 6.820 2.212 1.00 1.00 C +ATOM 2276 O2' G B 71 13.440 7.345 3.288 1.00 1.00 O +ATOM 2277 C1' G B 71 12.481 5.317 2.335 1.00 1.00 C +ATOM 2278 N9 G B 71 12.325 4.634 1.043 1.00 1.00 N +ATOM 2279 C8 G B 71 11.167 4.202 0.448 1.00 1.00 C +ATOM 2280 N7 G B 71 11.347 3.643 -0.715 1.00 1.00 N +ATOM 2281 C5 G B 71 12.721 3.707 -0.910 1.00 1.00 C +ATOM 2282 C6 G B 71 13.505 3.253 -2.005 1.00 1.00 C +ATOM 2283 O6 G B 71 13.129 2.698 -3.035 1.00 1.00 O +ATOM 2284 N1 G B 71 14.855 3.509 -1.806 1.00 1.00 N +ATOM 2285 C2 G B 71 15.388 4.125 -0.695 1.00 1.00 C +ATOM 2286 N2 G B 71 16.711 4.283 -0.687 1.00 1.00 N +ATOM 2287 N3 G B 71 14.653 4.554 0.338 1.00 1.00 N +ATOM 2288 C4 G B 71 13.332 4.312 0.161 1.00 1.00 C +ATOM 2289 H5' G B 71 8.759 5.023 3.008 1.00 1.00 H +ATOM 2290 H5'' G B 71 8.399 6.761 3.018 1.00 1.00 H +ATOM 2291 H4' G B 71 10.447 6.644 4.135 1.00 1.00 H +ATOM 2292 H3' G B 71 10.797 7.383 1.259 1.00 1.00 H +ATOM 2293 H2' G B 71 13.107 7.065 1.246 1.00 1.00 H +ATOM 2294 HO2' G B 71 14.045 6.651 3.565 1.00 1.00 H +ATOM 2295 H1' G B 71 13.330 4.891 2.868 1.00 1.00 H +ATOM 2296 H8 G B 71 10.186 4.311 0.909 1.00 1.00 H +ATOM 2297 H1 G B 71 15.476 3.214 -2.545 1.00 1.00 H +ATOM 2298 H21 G B 71 17.262 3.957 -1.468 1.00 1.00 H +ATOM 2299 H22 G B 71 17.162 4.726 0.099 1.00 1.00 H +ATOM 2300 P U B 72 11.168 9.966 2.056 1.00 1.00 P +ATOM 2301 OP1 U B 72 10.854 11.087 2.970 1.00 1.00 O +ATOM 2302 OP2 U B 72 10.336 9.743 0.853 1.00 1.00 O +ATOM 2303 O5' U B 72 12.702 10.112 1.585 1.00 1.00 O +ATOM 2304 C5' U B 72 13.730 10.404 2.535 1.00 1.00 C +ATOM 2305 C4' U B 72 15.105 10.486 1.873 1.00 1.00 C +ATOM 2306 O4' U B 72 15.478 9.202 1.372 1.00 1.00 O +ATOM 2307 C3' U B 72 15.178 11.454 0.701 1.00 1.00 C +ATOM 2308 O3' U B 72 15.612 12.740 1.164 1.00 1.00 O +ATOM 2309 C2' U B 72 16.234 10.834 -0.199 1.00 1.00 C +ATOM 2310 O2' U B 72 17.546 11.305 0.127 1.00 1.00 O +ATOM 2311 C1' U B 72 16.087 9.343 0.077 1.00 1.00 C +ATOM 2312 N1 U B 72 15.219 8.647 -0.892 1.00 1.00 N +ATOM 2313 C2 U B 72 15.814 8.060 -1.992 1.00 1.00 C +ATOM 2314 O2 U B 72 17.028 8.109 -2.182 1.00 1.00 O +ATOM 2315 N3 U B 72 14.964 7.415 -2.872 1.00 1.00 N +ATOM 2316 C4 U B 72 13.589 7.307 -2.749 1.00 1.00 C +ATOM 2317 O4 U B 72 12.930 6.708 -3.596 1.00 1.00 O +ATOM 2318 C5 U B 72 13.053 7.947 -1.570 1.00 1.00 C +ATOM 2319 C6 U B 72 13.866 8.586 -0.692 1.00 1.00 C +ATOM 2320 H5' U B 72 13.747 9.621 3.293 1.00 1.00 H +ATOM 2321 H5'' U B 72 13.510 11.359 3.016 1.00 1.00 H +ATOM 2322 H4' U B 72 15.836 10.785 2.622 1.00 1.00 H +ATOM 2323 H3' U B 72 14.216 11.517 0.189 1.00 1.00 H +ATOM 2324 H2' U B 72 15.998 11.036 -1.242 1.00 1.00 H +ATOM 2325 HO2' U B 72 17.844 11.846 -0.608 1.00 1.00 H +ATOM 2326 H1' U B 72 17.071 8.874 0.087 1.00 1.00 H +ATOM 2327 H3 U B 72 15.386 6.983 -3.681 1.00 1.00 H +ATOM 2328 H5 U B 72 11.980 7.918 -1.383 1.00 1.00 H +ATOM 2329 H6 U B 72 13.434 9.061 0.188 1.00 1.00 H +ATOM 2330 P U B 73 15.051 14.094 0.491 1.00 1.00 P +ATOM 2331 OP1 U B 73 15.486 15.238 1.322 1.00 1.00 O +ATOM 2332 OP2 U B 73 13.614 13.903 0.198 1.00 1.00 O +ATOM 2333 O5' U B 73 15.844 14.160 -0.911 1.00 1.00 O +ATOM 2334 C5' U B 73 17.181 14.671 -0.965 1.00 1.00 C +ATOM 2335 C4' U B 73 17.829 14.427 -2.327 1.00 1.00 C +ATOM 2336 O4' U B 73 17.722 13.049 -2.680 1.00 1.00 O +ATOM 2337 C3' U B 73 17.203 15.205 -3.472 1.00 1.00 C +ATOM 2338 O3' U B 73 17.820 16.493 -3.585 1.00 1.00 O +ATOM 2339 C2' U B 73 17.548 14.352 -4.681 1.00 1.00 C +ATOM 2340 O2' U B 73 18.825 14.707 -5.225 1.00 1.00 O +ATOM 2341 C1' U B 73 17.558 12.938 -4.102 1.00 1.00 C +ATOM 2342 N1 U B 73 16.314 12.193 -4.342 1.00 1.00 N +ATOM 2343 C2 U B 73 16.224 11.466 -5.514 1.00 1.00 C +ATOM 2344 O2 U B 73 17.124 11.459 -6.352 1.00 1.00 O +ATOM 2345 N3 U B 73 15.055 10.748 -5.695 1.00 1.00 N +ATOM 2346 C4 U B 73 13.986 10.694 -4.817 1.00 1.00 C +ATOM 2347 O4 U B 73 12.994 10.017 -5.078 1.00 1.00 O +ATOM 2348 C5 U B 73 14.167 11.485 -3.620 1.00 1.00 C +ATOM 2349 C6 U B 73 15.303 12.196 -3.421 1.00 1.00 C +ATOM 2350 H5' U B 73 17.778 14.182 -0.195 1.00 1.00 H +ATOM 2351 H5'' U B 73 17.159 15.743 -0.768 1.00 1.00 H +ATOM 2352 H4' U B 73 18.884 14.679 -2.264 1.00 1.00 H +ATOM 2353 H3' U B 73 16.122 15.287 -3.347 1.00 1.00 H +ATOM 2354 H2' U B 73 16.765 14.440 -5.437 1.00 1.00 H +ATOM 2355 HO2' U B 73 18.681 15.427 -5.843 1.00 1.00 H +ATOM 2356 H1' U B 73 18.394 12.373 -4.516 1.00 1.00 H +ATOM 2357 H3 U B 73 14.975 10.211 -6.547 1.00 1.00 H +ATOM 2358 H5 U B 73 13.380 11.508 -2.868 1.00 1.00 H +ATOM 2359 H6 U B 73 15.412 12.785 -2.511 1.00 1.00 H +ATOM 2360 P C B 74 16.948 17.784 -3.992 1.00 1.00 P +ATOM 2361 OP1 C B 74 17.847 18.961 -4.017 1.00 1.00 O +ATOM 2362 OP2 C B 74 15.732 17.805 -3.150 1.00 1.00 O +ATOM 2363 O5' C B 74 16.504 17.460 -5.507 1.00 1.00 O +ATOM 2364 C5' C B 74 17.398 17.707 -6.596 1.00 1.00 C +ATOM 2365 C4' C B 74 16.917 17.046 -7.887 1.00 1.00 C +ATOM 2366 O4' C B 74 16.719 15.650 -7.673 1.00 1.00 O +ATOM 2367 C3' C B 74 15.594 17.572 -8.422 1.00 1.00 C +ATOM 2368 O3' C B 74 15.812 18.714 -9.260 1.00 1.00 O +ATOM 2369 C2' C B 74 15.097 16.405 -9.260 1.00 1.00 C +ATOM 2370 O2' C B 74 15.565 16.489 -10.614 1.00 1.00 O +ATOM 2371 C1' C B 74 15.674 15.188 -8.542 1.00 1.00 C +ATOM 2372 N1 C B 74 14.684 14.462 -7.718 1.00 1.00 N +ATOM 2373 C2 C B 74 14.050 13.374 -8.299 1.00 1.00 C +ATOM 2374 O2 C B 74 14.298 13.068 -9.464 1.00 1.00 O +ATOM 2375 N3 C B 74 13.156 12.672 -7.550 1.00 1.00 N +ATOM 2376 C4 C B 74 12.894 13.022 -6.283 1.00 1.00 C +ATOM 2377 N4 C B 74 12.013 12.313 -5.577 1.00 1.00 N +ATOM 2378 C5 C B 74 13.546 14.144 -5.680 1.00 1.00 C +ATOM 2379 C6 C B 74 14.429 14.832 -6.430 1.00 1.00 C +ATOM 2380 H5' C B 74 18.382 17.313 -6.342 1.00 1.00 H +ATOM 2381 H5'' C B 74 17.477 18.783 -6.754 1.00 1.00 H +ATOM 2382 H4' C B 74 17.681 17.168 -8.652 1.00 1.00 H +ATOM 2383 H3' C B 74 14.901 17.794 -7.609 1.00 1.00 H +ATOM 2384 H2' C B 74 14.016 16.366 -9.230 1.00 1.00 H +ATOM 2385 HO2' C B 74 16.409 16.946 -10.598 1.00 1.00 H +ATOM 2386 H1' C B 74 16.101 14.502 -9.274 1.00 1.00 H +ATOM 2387 H41 C B 74 11.552 11.521 -5.997 1.00 1.00 H +ATOM 2388 H42 C B 74 11.808 12.568 -4.621 1.00 1.00 H +ATOM 2389 H5 C B 74 13.336 14.432 -4.649 1.00 1.00 H +ATOM 2390 H6 C B 74 14.944 15.693 -6.003 1.00 1.00 H +ATOM 2391 P U B 75 14.929 20.054 -9.074 1.00 1.00 P +ATOM 2392 OP1 U B 75 15.745 21.206 -9.515 1.00 1.00 O +ATOM 2393 OP2 U B 75 14.358 20.044 -7.708 1.00 1.00 O +ATOM 2394 O5' U B 75 13.716 19.871 -10.127 1.00 1.00 O +ATOM 2395 C5' U B 75 13.991 19.540 -11.493 1.00 1.00 C +ATOM 2396 C4' U B 75 13.085 18.417 -12.026 1.00 1.00 C +ATOM 2397 O4' U B 75 13.147 17.278 -11.177 1.00 1.00 O +ATOM 2398 C3' U B 75 11.609 18.763 -12.129 1.00 1.00 C +ATOM 2399 O3' U B 75 11.343 19.392 -13.387 1.00 1.00 O +ATOM 2400 C2' U B 75 10.937 17.396 -12.094 1.00 1.00 C +ATOM 2401 O2' U B 75 10.665 16.910 -13.413 1.00 1.00 O +ATOM 2402 C1' U B 75 11.948 16.511 -11.368 1.00 1.00 C +ATOM 2403 N1 U B 75 11.475 16.024 -10.051 1.00 1.00 N +ATOM 2404 C2 U B 75 10.885 14.774 -10.022 1.00 1.00 C +ATOM 2405 O2 U B 75 10.746 14.091 -11.034 1.00 1.00 O +ATOM 2406 N3 U B 75 10.457 14.333 -8.782 1.00 1.00 N +ATOM 2407 C4 U B 75 10.566 15.024 -7.587 1.00 1.00 C +ATOM 2408 O4 U B 75 10.151 14.533 -6.539 1.00 1.00 O +ATOM 2409 C5 U B 75 11.194 16.321 -7.713 1.00 1.00 C +ATOM 2410 C6 U B 75 11.621 16.773 -8.916 1.00 1.00 C +ATOM 2411 H5' U B 75 15.030 19.222 -11.575 1.00 1.00 H +ATOM 2412 H5'' U B 75 13.846 20.429 -12.107 1.00 1.00 H +ATOM 2413 H4' U B 75 13.442 18.125 -13.010 1.00 1.00 H +ATOM 2414 H3' U B 75 11.287 19.382 -11.290 1.00 1.00 H +ATOM 2415 H2' U B 75 10.024 17.451 -11.509 1.00 1.00 H +ATOM 2416 HO2' U B 75 9.917 16.310 -13.347 1.00 1.00 H +ATOM 2417 H1' U B 75 12.182 15.654 -12.003 1.00 1.00 H +ATOM 2418 H3 U B 75 10.024 13.421 -8.745 1.00 1.00 H +ATOM 2419 H5 U B 75 11.326 16.942 -6.827 1.00 1.00 H +ATOM 2420 H6 U B 75 12.091 17.756 -8.982 1.00 1.00 H +ATOM 2421 P U B 76 10.074 20.370 -13.579 1.00 1.00 P +ATOM 2422 OP1 U B 76 10.111 20.902 -14.960 1.00 1.00 O +ATOM 2423 OP2 U B 76 10.028 21.304 -12.433 1.00 1.00 O +ATOM 2424 O5' U B 76 8.817 19.365 -13.464 1.00 1.00 O +ATOM 2425 C5' U B 76 8.585 18.367 -14.464 1.00 1.00 C +ATOM 2426 C4' U B 76 7.452 17.415 -14.070 1.00 1.00 C +ATOM 2427 O4' U B 76 7.827 16.647 -12.937 1.00 1.00 O +ATOM 2428 C3' U B 76 6.148 18.098 -13.700 1.00 1.00 C +ATOM 2429 O3' U B 76 5.346 18.266 -14.871 1.00 1.00 O +ATOM 2430 C2' U B 76 5.481 17.109 -12.751 1.00 1.00 C +ATOM 2431 O2' U B 76 4.535 16.280 -13.434 1.00 1.00 O +ATOM 2432 C1' U B 76 6.649 16.287 -12.198 1.00 1.00 C +ATOM 2433 N1 U B 76 6.934 16.539 -10.772 1.00 1.00 N +ATOM 2434 C2 U B 76 6.426 15.650 -9.843 1.00 1.00 C +ATOM 2435 O2 U B 76 5.759 14.670 -10.172 1.00 1.00 O +ATOM 2436 N3 U B 76 6.712 15.925 -8.519 1.00 1.00 N +ATOM 2437 C4 U B 76 7.451 16.998 -8.049 1.00 1.00 C +ATOM 2438 O4 U B 76 7.644 17.147 -6.844 1.00 1.00 O +ATOM 2439 C5 U B 76 7.943 17.874 -9.089 1.00 1.00 C +ATOM 2440 C6 U B 76 7.675 17.625 -10.393 1.00 1.00 C +ATOM 2441 H5' U B 76 9.498 17.791 -14.604 1.00 1.00 H +ATOM 2442 H5'' U B 76 8.326 18.857 -15.402 1.00 1.00 H +ATOM 2443 H4' U B 76 7.267 16.734 -14.898 1.00 1.00 H +ATOM 2444 H3' U B 76 6.334 19.052 -13.202 1.00 1.00 H +ATOM 2445 H2' U B 76 4.997 17.653 -11.935 1.00 1.00 H +ATOM 2446 HO2' U B 76 4.898 16.086 -14.300 1.00 1.00 H +ATOM 2447 H1' U B 76 6.444 15.226 -12.345 1.00 1.00 H +ATOM 2448 H3 U B 76 6.348 15.285 -7.829 1.00 1.00 H +ATOM 2449 H5 U B 76 8.536 18.748 -8.820 1.00 1.00 H +ATOM 2450 H6 U B 76 8.058 18.303 -11.157 1.00 1.00 H +ATOM 2451 P C B 77 4.038 19.203 -14.839 1.00 1.00 P +ATOM 2452 OP1 C B 77 3.355 19.089 -16.147 1.00 1.00 O +ATOM 2453 OP2 C B 77 4.431 20.533 -14.324 1.00 1.00 O +ATOM 2454 O5' C B 77 3.122 18.479 -13.729 1.00 1.00 O +ATOM 2455 C5' C B 77 2.423 19.248 -12.747 1.00 1.00 C +ATOM 2456 C4' C B 77 1.467 18.380 -11.931 1.00 1.00 C +ATOM 2457 O4' C B 77 2.210 17.462 -11.133 1.00 1.00 O +ATOM 2458 C3' C B 77 0.579 19.167 -10.981 1.00 1.00 C +ATOM 2459 O3' C B 77 -0.672 19.445 -11.614 1.00 1.00 O +ATOM 2460 C2' C B 77 0.356 18.220 -9.810 1.00 1.00 C +ATOM 2461 O2' C B 77 -0.894 17.530 -9.932 1.00 1.00 O +ATOM 2462 C1' C B 77 1.535 17.251 -9.886 1.00 1.00 C +ATOM 2463 N1 C B 77 2.527 17.437 -8.813 1.00 1.00 N +ATOM 2464 C2 C B 77 2.284 16.815 -7.599 1.00 1.00 C +ATOM 2465 O2 C B 77 1.268 16.142 -7.443 1.00 1.00 O +ATOM 2466 N3 C B 77 3.196 16.972 -6.599 1.00 1.00 N +ATOM 2467 C4 C B 77 4.298 17.710 -6.784 1.00 1.00 C +ATOM 2468 N4 C B 77 5.171 17.842 -5.785 1.00 1.00 N +ATOM 2469 C5 C B 77 4.552 18.356 -8.036 1.00 1.00 C +ATOM 2470 C6 C B 77 3.644 18.194 -9.018 1.00 1.00 C +ATOM 2471 H5' C B 77 1.852 20.030 -13.249 1.00 1.00 H +ATOM 2472 H5'' C B 77 3.146 19.712 -12.077 1.00 1.00 H +ATOM 2473 H4' C B 77 0.838 17.813 -12.612 1.00 1.00 H +ATOM 2474 H3' C B 77 1.072 20.083 -10.653 1.00 1.00 H +ATOM 2475 H2' C B 77 0.395 18.778 -8.872 1.00 1.00 H +ATOM 2476 HO2' C B 77 -0.847 16.991 -10.725 1.00 1.00 H +ATOM 2477 H1' C B 77 1.160 16.228 -9.850 1.00 1.00 H +ATOM 2478 H41 C B 77 4.997 17.389 -4.903 1.00 1.00 H +ATOM 2479 H42 C B 77 6.006 18.396 -5.914 1.00 1.00 H +ATOM 2480 H5 C B 77 5.447 18.958 -8.188 1.00 1.00 H +ATOM 2481 H6 C B 77 3.804 18.670 -9.985 1.00 1.00 H +ATOM 2482 P C B 78 -1.691 20.508 -10.965 1.00 1.00 P +ATOM 2483 OP1 C B 78 -3.006 20.349 -11.627 1.00 1.00 O +ATOM 2484 OP2 C B 78 -1.031 21.832 -10.944 1.00 1.00 O +ATOM 2485 O5' C B 78 -1.824 19.983 -9.449 1.00 1.00 O +ATOM 2486 C5' C B 78 -1.664 20.887 -8.352 1.00 1.00 C +ATOM 2487 C4' C B 78 -2.418 20.408 -7.113 1.00 1.00 C +ATOM 2488 O4' C B 78 -1.726 19.308 -6.520 1.00 1.00 O +ATOM 2489 C3' C B 78 -2.569 21.475 -6.041 1.00 1.00 C +ATOM 2490 O3' C B 78 -3.843 22.111 -6.180 1.00 1.00 O +ATOM 2491 C2' C B 78 -2.518 20.700 -4.733 1.00 1.00 C +ATOM 2492 O2' C B 78 -3.833 20.386 -4.262 1.00 1.00 O +ATOM 2493 C1' C B 78 -1.740 19.435 -5.090 1.00 1.00 C +ATOM 2494 N1 C B 78 -0.337 19.445 -4.632 1.00 1.00 N +ATOM 2495 C2 C B 78 -0.104 19.350 -3.270 1.00 1.00 C +ATOM 2496 O2 C B 78 -1.048 19.263 -2.488 1.00 1.00 O +ATOM 2497 N3 C B 78 1.186 19.357 -2.833 1.00 1.00 N +ATOM 2498 C4 C B 78 2.205 19.453 -3.698 1.00 1.00 C +ATOM 2499 N4 C B 78 3.455 19.457 -3.238 1.00 1.00 N +ATOM 2500 C5 C B 78 1.968 19.551 -5.106 1.00 1.00 C +ATOM 2501 C6 C B 78 0.689 19.544 -5.527 1.00 1.00 C +ATOM 2502 H5' C B 78 -2.042 21.867 -8.641 1.00 1.00 H +ATOM 2503 H5'' C B 78 -0.605 20.971 -8.112 1.00 1.00 H +ATOM 2504 H4' C B 78 -3.408 20.070 -7.414 1.00 1.00 H +ATOM 2505 H3' C B 78 -1.755 22.200 -6.096 1.00 1.00 H +ATOM 2506 H2' C B 78 -1.967 21.274 -3.984 1.00 1.00 H +ATOM 2507 HO2' C B 78 -4.092 19.559 -4.673 1.00 1.00 H +ATOM 2508 H1' C B 78 -2.248 18.572 -4.660 1.00 1.00 H +ATOM 2509 H41 C B 78 3.627 19.387 -2.247 1.00 1.00 H +ATOM 2510 H42 C B 78 4.231 19.528 -3.882 1.00 1.00 H +ATOM 2511 H5 C B 78 2.794 19.632 -5.813 1.00 1.00 H +ATOM 2512 H6 C B 78 0.470 19.619 -6.592 1.00 1.00 H +ATOM 2513 P U B 79 -4.162 23.476 -5.392 1.00 1.00 P +ATOM 2514 OP1 U B 79 -5.430 24.031 -5.918 1.00 1.00 O +ATOM 2515 OP2 U B 79 -2.937 24.307 -5.385 1.00 1.00 O +ATOM 2516 O5' U B 79 -4.424 22.952 -3.893 1.00 1.00 O +ATOM 2517 C5' U B 79 -4.028 23.740 -2.770 1.00 1.00 C +ATOM 2518 C4' U B 79 -4.020 22.917 -1.487 1.00 1.00 C +ATOM 2519 O4' U B 79 -2.934 21.995 -1.508 1.00 1.00 O +ATOM 2520 C3' U B 79 -3.867 23.750 -0.226 1.00 1.00 C +ATOM 2521 O3' U B 79 -5.164 24.060 0.294 1.00 1.00 O +ATOM 2522 C2' U B 79 -3.124 22.832 0.736 1.00 1.00 C +ATOM 2523 O2' U B 79 -4.025 22.177 1.634 1.00 1.00 O +ATOM 2524 C1' U B 79 -2.425 21.825 -0.179 1.00 1.00 C +ATOM 2525 N1 U B 79 -0.962 21.992 -0.236 1.00 1.00 N +ATOM 2526 C2 U B 79 -0.253 21.778 0.931 1.00 1.00 C +ATOM 2527 O2 U B 79 -0.808 21.475 1.985 1.00 1.00 O +ATOM 2528 N3 U B 79 1.119 21.928 0.845 1.00 1.00 N +ATOM 2529 C4 U B 79 1.834 22.270 -0.292 1.00 1.00 C +ATOM 2530 O4 U B 79 3.057 22.374 -0.254 1.00 1.00 O +ATOM 2531 C5 U B 79 1.012 22.475 -1.464 1.00 1.00 C +ATOM 2532 C6 U B 79 -0.334 22.334 -1.403 1.00 1.00 C +ATOM 2533 H5' U B 79 -4.722 24.572 -2.654 1.00 1.00 H +ATOM 2534 H5'' U B 79 -3.027 24.134 -2.947 1.00 1.00 H +ATOM 2535 H4' U B 79 -4.949 22.353 -1.425 1.00 1.00 H +ATOM 2536 H3' U B 79 -3.292 24.655 -0.425 1.00 1.00 H +ATOM 2537 H2' U B 79 -2.378 23.406 1.291 1.00 1.00 H +ATOM 2538 HO2' U B 79 -3.556 21.428 2.012 1.00 1.00 H +ATOM 2539 H1' U B 79 -2.652 20.816 0.162 1.00 1.00 H +ATOM 2540 H3 U B 79 1.649 21.775 1.689 1.00 1.00 H +ATOM 2541 H5 U B 79 1.483 22.747 -2.408 1.00 1.00 H +ATOM 2542 H6 U B 79 -0.929 22.495 -2.303 1.00 1.00 H +ATOM 2543 P A B 80 -5.429 25.442 1.073 1.00 1.00 P +ATOM 2544 OP1 A B 80 -6.881 25.549 1.343 1.00 1.00 O +ATOM 2545 OP2 A B 80 -4.732 26.527 0.348 1.00 1.00 O +ATOM 2546 O5' A B 80 -4.674 25.206 2.474 1.00 1.00 O +ATOM 2547 C5' A B 80 -5.123 24.190 3.372 1.00 1.00 C +ATOM 2548 C4' A B 80 -4.348 24.218 4.685 1.00 1.00 C +ATOM 2549 O4' A B 80 -3.017 23.749 4.454 1.00 1.00 O +ATOM 2550 C3' A B 80 -4.256 25.603 5.320 1.00 1.00 C +ATOM 2551 O3' A B 80 -4.461 25.497 6.732 1.00 1.00 O +ATOM 2552 C2' A B 80 -2.831 26.055 5.042 1.00 1.00 C +ATOM 2553 O2' A B 80 -2.302 26.806 6.142 1.00 1.00 O +ATOM 2554 C1' A B 80 -2.072 24.749 4.845 1.00 1.00 C +ATOM 2555 N9 A B 80 -1.032 24.806 3.800 1.00 1.00 N +ATOM 2556 C8 A B 80 -1.100 25.354 2.546 1.00 1.00 C +ATOM 2557 N7 A B 80 0.003 25.239 1.859 1.00 1.00 N +ATOM 2558 C5 A B 80 0.865 24.566 2.720 1.00 1.00 C +ATOM 2559 C6 A B 80 2.195 24.137 2.588 1.00 1.00 C +ATOM 2560 N6 A B 80 2.918 24.331 1.485 1.00 1.00 N +ATOM 2561 N1 A B 80 2.744 23.502 3.637 1.00 1.00 N +ATOM 2562 C2 A B 80 2.018 23.309 4.732 1.00 1.00 C +ATOM 2563 N3 A B 80 0.765 23.663 4.976 1.00 1.00 N +ATOM 2564 C4 A B 80 0.242 24.299 3.907 1.00 1.00 C +ATOM 2565 H5' A B 80 -4.992 23.216 2.901 1.00 1.00 H +ATOM 2566 H5'' A B 80 -6.182 24.343 3.581 1.00 1.00 H +ATOM 2567 H4' A B 80 -4.831 23.541 5.389 1.00 1.00 H +ATOM 2568 H3' A B 80 -4.975 26.287 4.866 1.00 1.00 H +ATOM 2569 H2' A B 80 -2.802 26.646 4.124 1.00 1.00 H +ATOM 2570 HO2' A B 80 -1.519 26.346 6.452 1.00 1.00 H +ATOM 2571 H1' A B 80 -1.614 24.454 5.788 1.00 1.00 H +ATOM 2572 H8 A B 80 -1.994 25.842 2.157 1.00 1.00 H +ATOM 2573 H61 A B 80 3.871 24.002 1.441 1.00 1.00 H +ATOM 2574 H62 A B 80 2.512 24.808 0.692 1.00 1.00 H +ATOM 2575 H2 A B 80 2.525 22.788 5.544 1.00 1.00 H +ATOM 2576 P A B 81 -5.934 25.213 7.317 1.00 1.00 P +ATOM 2577 OP1 A B 81 -6.033 23.771 7.636 1.00 1.00 O +ATOM 2578 OP2 A B 81 -6.920 25.836 6.406 1.00 1.00 O +ATOM 2579 O5' A B 81 -5.938 26.036 8.702 1.00 1.00 O +ATOM 2580 C5' A B 81 -4.828 25.962 9.600 1.00 1.00 C +ATOM 2581 C4' A B 81 -4.924 24.742 10.511 1.00 1.00 C +ATOM 2582 O4' A B 81 -4.880 23.554 9.718 1.00 1.00 O +ATOM 2583 C3' A B 81 -3.803 24.650 11.544 1.00 1.00 C +ATOM 2584 O3' A B 81 -4.283 25.093 12.819 1.00 1.00 O +ATOM 2585 C2' A B 81 -3.478 23.167 11.609 1.00 1.00 C +ATOM 2586 O2' A B 81 -4.212 22.517 12.652 1.00 1.00 O +ATOM 2587 C1' A B 81 -3.893 22.656 10.237 1.00 1.00 C +ATOM 2588 N9 A B 81 -2.789 22.596 9.262 1.00 1.00 N +ATOM 2589 C8 A B 81 -2.626 23.304 8.100 1.00 1.00 C +ATOM 2590 N7 A B 81 -1.534 23.007 7.451 1.00 1.00 N +ATOM 2591 C5 A B 81 -0.931 22.032 8.240 1.00 1.00 C +ATOM 2592 C6 A B 81 0.262 21.304 8.103 1.00 1.00 C +ATOM 2593 N6 A B 81 1.096 21.456 7.074 1.00 1.00 N +ATOM 2594 N1 A B 81 0.556 20.417 9.069 1.00 1.00 N +ATOM 2595 C2 A B 81 -0.277 20.271 10.092 1.00 1.00 C +ATOM 2596 N3 A B 81 -1.421 20.894 10.331 1.00 1.00 N +ATOM 2597 C4 A B 81 -1.689 21.776 9.347 1.00 1.00 C +ATOM 2598 H5' A B 81 -4.806 26.863 10.213 1.00 1.00 H +ATOM 2599 H5'' A B 81 -3.905 25.903 9.023 1.00 1.00 H +ATOM 2600 H4' A B 81 -5.879 24.770 11.033 1.00 1.00 H +ATOM 2601 H3' A B 81 -2.933 25.226 11.226 1.00 1.00 H +ATOM 2602 H2' A B 81 -2.404 23.027 11.747 1.00 1.00 H +ATOM 2603 HO2' A B 81 -3.584 22.002 13.164 1.00 1.00 H +ATOM 2604 H1' A B 81 -4.329 21.663 10.342 1.00 1.00 H +ATOM 2605 H8 A B 81 -3.344 24.045 7.749 1.00 1.00 H +ATOM 2606 H61 A B 81 1.942 20.907 7.023 1.00 1.00 H +ATOM 2607 H62 A B 81 0.882 22.121 6.345 1.00 1.00 H +ATOM 2608 H2 A B 81 0.022 19.534 10.837 1.00 1.00 H +ATOM 2609 P G B 82 -3.286 25.802 13.866 1.00 1.00 P +ATOM 2610 OP1 G B 82 -4.002 25.957 15.153 1.00 1.00 O +ATOM 2611 OP2 G B 82 -2.688 26.984 13.208 1.00 1.00 O +ATOM 2612 O5' G B 82 -2.131 24.697 14.063 1.00 1.00 O +ATOM 2613 C5' G B 82 -2.327 23.585 14.941 1.00 1.00 C +ATOM 2614 C4' G B 82 -1.234 22.533 14.767 1.00 1.00 C +ATOM 2615 O4' G B 82 -1.133 22.178 13.386 1.00 1.00 O +ATOM 2616 C3' G B 82 0.149 22.993 15.220 1.00 1.00 C +ATOM 2617 O3' G B 82 0.418 22.491 16.533 1.00 1.00 O +ATOM 2618 C2' G B 82 1.093 22.344 14.222 1.00 1.00 C +ATOM 2619 O2' G B 82 1.549 21.069 14.682 1.00 1.00 O +ATOM 2620 C1' G B 82 0.237 22.209 12.972 1.00 1.00 C +ATOM 2621 N9 G B 82 0.391 23.325 12.022 1.00 1.00 N +ATOM 2622 C8 G B 82 -0.303 24.505 11.963 1.00 1.00 C +ATOM 2623 N7 G B 82 0.068 25.288 10.988 1.00 1.00 N +ATOM 2624 C5 G B 82 1.082 24.576 10.353 1.00 1.00 C +ATOM 2625 C6 G B 82 1.867 24.925 9.221 1.00 1.00 C +ATOM 2626 O6 G B 82 1.821 25.951 8.545 1.00 1.00 O +ATOM 2627 N1 G B 82 2.778 23.925 8.906 1.00 1.00 N +ATOM 2628 C2 G B 82 2.919 22.738 9.594 1.00 1.00 C +ATOM 2629 N2 G B 82 3.850 21.900 9.140 1.00 1.00 N +ATOM 2630 N3 G B 82 2.181 22.408 10.659 1.00 1.00 N +ATOM 2631 C4 G B 82 1.286 23.372 10.981 1.00 1.00 C +ATOM 2632 H5' G B 82 -3.295 23.130 14.730 1.00 1.00 H +ATOM 2633 H5'' G B 82 -2.319 23.940 15.972 1.00 1.00 H +ATOM 2634 H4' G B 82 -1.509 21.643 15.330 1.00 1.00 H +ATOM 2635 H3' G B 82 0.229 24.081 15.184 1.00 1.00 H +ATOM 2636 H2' G B 82 1.936 23.006 14.020 1.00 1.00 H +ATOM 2637 HO2' G B 82 2.348 20.857 14.194 1.00 1.00 H +ATOM 2638 H1' G B 82 0.483 21.275 12.468 1.00 1.00 H +ATOM 2639 H8 G B 82 -1.096 24.766 12.665 1.00 1.00 H +ATOM 2640 H1 G B 82 3.375 24.102 8.110 1.00 1.00 H +ATOM 2641 H21 G B 82 4.405 22.152 8.334 1.00 1.00 H +ATOM 2642 H22 G B 82 4.000 21.014 9.600 1.00 1.00 H +ATOM 2643 P U B 83 1.260 23.371 17.589 1.00 1.00 P +ATOM 2644 OP1 U B 83 1.312 22.629 18.870 1.00 1.00 O +ATOM 2645 OP2 U B 83 0.738 24.754 17.559 1.00 1.00 O +ATOM 2646 O5' U B 83 2.739 23.378 16.953 1.00 1.00 O +ATOM 2647 C5' U B 83 3.509 22.176 16.882 1.00 1.00 C +ATOM 2648 C4' U B 83 4.823 22.396 16.135 1.00 1.00 C +ATOM 2649 O4' U B 83 4.561 22.622 14.753 1.00 1.00 O +ATOM 2650 C3' U B 83 5.627 23.586 16.635 1.00 1.00 C +ATOM 2651 O3' U B 83 6.557 23.151 17.634 1.00 1.00 O +ATOM 2652 C2' U B 83 6.373 24.050 15.392 1.00 1.00 C +ATOM 2653 O2' U B 83 7.651 23.414 15.285 1.00 1.00 O +ATOM 2654 C1' U B 83 5.445 23.634 14.250 1.00 1.00 C +ATOM 2655 N1 U B 83 4.601 24.733 13.738 1.00 1.00 N +ATOM 2656 C2 U B 83 5.036 25.410 12.613 1.00 1.00 C +ATOM 2657 O2 U B 83 6.085 25.121 12.041 1.00 1.00 O +ATOM 2658 N3 U B 83 4.221 26.435 12.168 1.00 1.00 N +ATOM 2659 C4 U B 83 3.026 26.837 12.742 1.00 1.00 C +ATOM 2660 O4 U B 83 2.380 27.764 12.259 1.00 1.00 O +ATOM 2661 C5 U B 83 2.650 26.074 13.912 1.00 1.00 C +ATOM 2662 C6 U B 83 3.432 25.065 14.366 1.00 1.00 C +ATOM 2663 H5' U B 83 2.929 21.413 16.362 1.00 1.00 H +ATOM 2664 H5'' U B 83 3.726 21.830 17.893 1.00 1.00 H +ATOM 2665 H4' U B 83 5.431 21.497 16.226 1.00 1.00 H +ATOM 2666 H3' U B 83 4.970 24.372 17.012 1.00 1.00 H +ATOM 2667 H2' U B 83 6.481 25.137 15.406 1.00 1.00 H +ATOM 2668 HO2' U B 83 7.963 23.248 16.178 1.00 1.00 H +ATOM 2669 H1' U B 83 6.039 23.220 13.434 1.00 1.00 H +ATOM 2670 H3 U B 83 4.526 26.938 11.348 1.00 1.00 H +ATOM 2671 H5 U B 83 1.725 26.314 14.436 1.00 1.00 H +ATOM 2672 H6 U B 83 3.124 24.507 15.251 1.00 1.00 H +ATOM 2673 P C B 84 6.705 23.946 19.030 1.00 1.00 P +ATOM 2674 OP1 C B 84 7.566 23.143 19.928 1.00 1.00 O +ATOM 2675 OP2 C B 84 5.355 24.355 19.478 1.00 1.00 O +ATOM 2676 O5' C B 84 7.517 25.270 18.608 1.00 1.00 O +ATOM 2677 C5' C B 84 8.871 25.174 18.160 1.00 1.00 C +ATOM 2678 C4' C B 84 9.296 26.409 17.370 1.00 1.00 C +ATOM 2679 O4' C B 84 8.511 26.531 16.189 1.00 1.00 O +ATOM 2680 C3' C B 84 9.139 27.722 18.118 1.00 1.00 C +ATOM 2681 O3' C B 84 10.341 28.015 18.838 1.00 1.00 O +ATOM 2682 C2' C B 84 8.948 28.743 17.008 1.00 1.00 C +ATOM 2683 O2' C B 84 10.176 29.408 16.690 1.00 1.00 O +ATOM 2684 C1' C B 84 8.436 27.916 15.829 1.00 1.00 C +ATOM 2685 N1 C B 84 7.044 28.227 15.444 1.00 1.00 N +ATOM 2686 C2 C B 84 6.865 29.162 14.438 1.00 1.00 C +ATOM 2687 O2 C B 84 7.840 29.698 13.915 1.00 1.00 O +ATOM 2688 N3 C B 84 5.593 29.462 14.053 1.00 1.00 N +ATOM 2689 C4 C B 84 4.542 28.870 14.635 1.00 1.00 C +ATOM 2690 N4 C B 84 3.310 29.186 14.236 1.00 1.00 N +ATOM 2691 C5 C B 84 4.722 27.905 15.675 1.00 1.00 C +ATOM 2692 C6 C B 84 5.984 27.615 16.047 1.00 1.00 C +ATOM 2693 H5' C B 84 8.972 24.294 17.525 1.00 1.00 H +ATOM 2694 H5'' C B 84 9.526 25.063 19.025 1.00 1.00 H +ATOM 2695 H4' C B 84 10.338 26.296 17.077 1.00 1.00 H +ATOM 2696 H3' C B 84 8.271 27.696 18.779 1.00 1.00 H +ATOM 2697 H2' C B 84 8.182 29.464 17.305 1.00 1.00 H +ATOM 2698 HO2' C B 84 10.770 28.749 16.326 1.00 1.00 H +ATOM 2699 H1' C B 84 9.089 28.086 14.970 1.00 1.00 H +ATOM 2700 H41 C B 84 3.175 29.870 13.499 1.00 1.00 H +ATOM 2701 H42 C B 84 2.511 28.745 14.668 1.00 1.00 H +ATOM 2702 H5 C B 84 3.868 27.421 16.149 1.00 1.00 H +ATOM 2703 H6 C B 84 6.160 26.885 16.837 1.00 1.00 H +ATOM 2704 P C B 85 10.398 29.235 19.889 1.00 1.00 P +ATOM 2705 OP1 C B 85 11.499 28.974 20.843 1.00 1.00 O +ATOM 2706 OP2 C B 85 9.028 29.477 20.394 1.00 1.00 O +ATOM 2707 O5' C B 85 10.821 30.486 18.963 1.00 1.00 O +ATOM 2708 C5' C B 85 12.071 30.489 18.263 1.00 1.00 C +ATOM 2709 C4' C B 85 12.208 31.711 17.352 1.00 1.00 C +ATOM 2710 O4' C B 85 11.230 31.667 16.317 1.00 1.00 O +ATOM 2711 C3' C B 85 12.022 33.045 18.057 1.00 1.00 C +ATOM 2712 O3' C B 85 13.277 33.521 18.555 1.00 1.00 O +ATOM 2713 C2' C B 85 11.527 33.961 16.953 1.00 1.00 C +ATOM 2714 O2' C B 85 12.610 34.651 16.322 1.00 1.00 O +ATOM 2715 C1' C B 85 10.835 33.008 15.981 1.00 1.00 C +ATOM 2716 N1 C B 85 9.364 33.062 16.044 1.00 1.00 N +ATOM 2717 C2 C B 85 8.719 34.023 15.282 1.00 1.00 C +ATOM 2718 O2 C B 85 9.374 34.799 14.589 1.00 1.00 O +ATOM 2719 N3 C B 85 7.359 34.077 15.326 1.00 1.00 N +ATOM 2720 C4 C B 85 6.661 33.222 16.087 1.00 1.00 C +ATOM 2721 N4 C B 85 5.330 33.302 16.110 1.00 1.00 N +ATOM 2722 C5 C B 85 7.324 32.229 16.876 1.00 1.00 C +ATOM 2723 C6 C B 85 8.668 32.183 16.824 1.00 1.00 C +ATOM 2724 H5' C B 85 12.141 29.585 17.657 1.00 1.00 H +ATOM 2725 H5'' C B 85 12.884 30.494 18.989 1.00 1.00 H +ATOM 2726 H4' C B 85 13.194 31.694 16.892 1.00 1.00 H +ATOM 2727 H3' C B 85 11.282 32.964 18.856 1.00 1.00 H +ATOM 2728 H2' C B 85 10.803 34.669 17.356 1.00 1.00 H +ATOM 2729 HO2' C B 85 12.254 35.100 15.552 1.00 1.00 H +ATOM 2730 H1' C B 85 11.157 33.233 14.966 1.00 1.00 H +ATOM 2731 H41 C B 85 4.857 34.001 15.555 1.00 1.00 H +ATOM 2732 H42 C B 85 4.795 32.663 16.679 1.00 1.00 H +ATOM 2733 H5 C B 85 6.758 31.532 17.496 1.00 1.00 H +ATOM 2734 H6 C B 85 9.206 31.439 17.411 1.00 1.00 H +ATOM 2735 P U B 86 13.326 34.637 19.719 1.00 1.00 P +ATOM 2736 OP1 U B 86 14.719 35.125 19.829 1.00 1.00 O +ATOM 2737 OP2 U B 86 12.640 34.096 20.912 1.00 1.00 O +ATOM 2738 O5' U B 86 12.423 35.828 19.111 1.00 1.00 O +ATOM 2739 C5' U B 86 12.908 36.632 18.031 1.00 1.00 C +ATOM 2740 C4' U B 86 11.922 37.739 17.654 1.00 1.00 C +ATOM 2741 O4' U B 86 10.720 37.171 17.154 1.00 1.00 O +ATOM 2742 C3' U B 86 11.519 38.642 18.813 1.00 1.00 C +ATOM 2743 O3' U B 86 12.360 39.798 18.886 1.00 1.00 O +ATOM 2744 C2' U B 86 10.072 39.031 18.494 1.00 1.00 C +ATOM 2745 O2' U B 86 9.975 40.414 18.133 1.00 1.00 O +ATOM 2746 C1' U B 86 9.676 38.128 17.332 1.00 1.00 C +ATOM 2747 N1 U B 86 8.414 37.396 17.563 1.00 1.00 N +ATOM 2748 C2 U B 86 7.253 37.957 17.067 1.00 1.00 C +ATOM 2749 O2 U B 86 7.252 39.025 16.458 1.00 1.00 O +ATOM 2750 N3 U B 86 6.089 37.248 17.297 1.00 1.00 N +ATOM 2751 C4 U B 86 5.985 36.043 17.972 1.00 1.00 C +ATOM 2752 O4 U B 86 4.894 35.497 18.118 1.00 1.00 O +ATOM 2753 C5 U B 86 7.247 35.530 18.457 1.00 1.00 C +ATOM 2754 C6 U B 86 8.402 36.208 18.243 1.00 1.00 C +ATOM 2755 H5' U B 86 13.079 35.998 17.163 1.00 1.00 H +ATOM 2756 H5'' U B 86 13.854 37.088 18.326 1.00 1.00 H +ATOM 2757 H4' U B 86 12.365 38.350 16.870 1.00 1.00 H +ATOM 2758 H3' U B 86 11.554 38.080 19.750 1.00 1.00 H +ATOM 2759 HO3' U B 86 12.231 40.191 19.753 1.00 1.00 H +ATOM 2760 H2' U B 86 9.431 38.815 19.352 1.00 1.00 H +ATOM 2761 HO2' U B 86 10.094 40.471 17.181 1.00 1.00 H +ATOM 2762 H1' U B 86 9.586 38.728 16.427 1.00 1.00 H +ATOM 2763 H3 U B 86 5.232 37.646 16.940 1.00 1.00 H +ATOM 2764 H5 U B 86 7.270 34.587 19.004 1.00 1.00 H +ATOM 2765 H6 U B 86 9.340 35.799 18.621 1.00 1.00 H +TER 2766 U B 86 +ENDMDL +MODEL 7 +ATOM 1 O5' G A 1 6.824 -34.442 6.229 1.00 1.00 O +ATOM 2 C5' G A 1 8.118 -34.616 5.649 1.00 1.00 C +ATOM 3 C4' G A 1 8.163 -35.852 4.751 1.00 1.00 C +ATOM 4 O4' G A 1 8.238 -37.031 5.561 1.00 1.00 O +ATOM 5 C3' G A 1 6.946 -35.995 3.838 1.00 1.00 C +ATOM 6 O3' G A 1 7.299 -35.619 2.502 1.00 1.00 O +ATOM 7 C2' G A 1 6.625 -37.479 3.883 1.00 1.00 C +ATOM 8 O2' G A 1 7.290 -38.189 2.832 1.00 1.00 O +ATOM 9 C1' G A 1 7.141 -37.892 5.249 1.00 1.00 C +ATOM 10 N9 G A 1 6.150 -37.751 6.329 1.00 1.00 N +ATOM 11 C8 G A 1 6.175 -36.912 7.413 1.00 1.00 C +ATOM 12 N7 G A 1 5.141 -37.031 8.198 1.00 1.00 N +ATOM 13 C5 G A 1 4.372 -38.020 7.591 1.00 1.00 C +ATOM 14 C6 G A 1 3.125 -38.578 7.990 1.00 1.00 C +ATOM 15 O6 G A 1 2.444 -38.298 8.974 1.00 1.00 O +ATOM 16 N1 G A 1 2.694 -39.550 7.098 1.00 1.00 N +ATOM 17 C2 G A 1 3.375 -39.941 5.964 1.00 1.00 C +ATOM 18 N2 G A 1 2.802 -40.894 5.229 1.00 1.00 N +ATOM 19 N3 G A 1 4.546 -39.419 5.588 1.00 1.00 N +ATOM 20 C4 G A 1 4.982 -38.467 6.447 1.00 1.00 C +ATOM 21 H5' G A 1 8.853 -34.718 6.452 1.00 1.00 H +ATOM 22 H5'' G A 1 8.366 -33.740 5.055 1.00 1.00 H +ATOM 23 H4' G A 1 9.058 -35.800 4.134 1.00 1.00 H +ATOM 24 H3' G A 1 6.107 -35.402 4.209 1.00 1.00 H +ATOM 25 H2' G A 1 5.546 -37.633 3.832 1.00 1.00 H +ATOM 26 HO2' G A 1 7.474 -39.072 3.159 1.00 1.00 H +ATOM 27 H1' G A 1 7.489 -38.924 5.209 1.00 1.00 H +ATOM 28 H8 G A 1 6.987 -36.210 7.603 1.00 1.00 H +ATOM 29 H1 G A 1 1.812 -39.993 7.315 1.00 1.00 H +ATOM 30 H21 G A 1 1.916 -41.288 5.515 1.00 1.00 H +ATOM 31 H22 G A 1 3.252 -41.223 4.387 1.00 1.00 H +ATOM 32 HO5' G A 1 6.553 -33.537 6.057 1.00 1.00 H +ATOM 33 P G A 2 6.198 -34.999 1.501 1.00 1.00 P +ATOM 34 OP1 G A 2 6.786 -34.949 0.144 1.00 1.00 O +ATOM 35 OP2 G A 2 5.656 -33.767 2.116 1.00 1.00 O +ATOM 36 O5' G A 2 5.037 -36.114 1.501 1.00 1.00 O +ATOM 37 C5' G A 2 5.232 -37.377 0.857 1.00 1.00 C +ATOM 38 C4' G A 2 3.956 -38.214 0.882 1.00 1.00 C +ATOM 39 O4' G A 2 3.650 -38.601 2.221 1.00 1.00 O +ATOM 40 C3' G A 2 2.732 -37.491 0.343 1.00 1.00 C +ATOM 41 O3' G A 2 2.595 -37.740 -1.059 1.00 1.00 O +ATOM 42 C2' G A 2 1.582 -38.133 1.099 1.00 1.00 C +ATOM 43 O2' G A 2 1.039 -39.242 0.375 1.00 1.00 O +ATOM 44 C1' G A 2 2.227 -38.579 2.410 1.00 1.00 C +ATOM 45 N9 G A 2 1.949 -37.682 3.548 1.00 1.00 N +ATOM 46 C8 G A 2 2.721 -36.663 4.045 1.00 1.00 C +ATOM 47 N7 G A 2 2.198 -36.058 5.075 1.00 1.00 N +ATOM 48 C5 G A 2 0.991 -36.722 5.277 1.00 1.00 C +ATOM 49 C6 G A 2 -0.016 -36.507 6.259 1.00 1.00 C +ATOM 50 O6 G A 2 -0.039 -35.670 7.159 1.00 1.00 O +ATOM 51 N1 G A 2 -1.073 -37.396 6.108 1.00 1.00 N +ATOM 52 C2 G A 2 -1.153 -38.372 5.138 1.00 1.00 C +ATOM 53 N2 G A 2 -2.246 -39.132 5.153 1.00 1.00 N +ATOM 54 N3 G A 2 -0.207 -38.577 4.215 1.00 1.00 N +ATOM 55 C4 G A 2 0.831 -37.718 4.346 1.00 1.00 C +ATOM 56 H5' G A 2 6.026 -37.920 1.370 1.00 1.00 H +ATOM 57 H5'' G A 2 5.527 -37.207 -0.179 1.00 1.00 H +ATOM 58 H4' G A 2 4.118 -39.116 0.291 1.00 1.00 H +ATOM 59 H3' G A 2 2.790 -36.421 0.554 1.00 1.00 H +ATOM 60 H2' G A 2 0.811 -37.392 1.300 1.00 1.00 H +ATOM 61 HO2' G A 2 1.347 -40.042 0.805 1.00 1.00 H +ATOM 62 H1' G A 2 1.881 -39.582 2.658 1.00 1.00 H +ATOM 63 H8 G A 2 3.685 -36.384 3.618 1.00 1.00 H +ATOM 64 H1 G A 2 -1.829 -37.304 6.771 1.00 1.00 H +ATOM 65 H21 G A 2 -2.962 -38.975 5.849 1.00 1.00 H +ATOM 66 H22 G A 2 -2.361 -39.864 4.465 1.00 1.00 H +ATOM 67 P G A 3 2.013 -36.601 -2.038 1.00 1.00 P +ATOM 68 OP1 G A 3 1.877 -37.184 -3.391 1.00 1.00 O +ATOM 69 OP2 G A 3 2.813 -35.371 -1.842 1.00 1.00 O +ATOM 70 O5' G A 3 0.535 -36.341 -1.453 1.00 1.00 O +ATOM 71 C5' G A 3 -0.491 -37.327 -1.591 1.00 1.00 C +ATOM 72 C4' G A 3 -1.832 -36.821 -1.064 1.00 1.00 C +ATOM 73 O4' G A 3 -1.845 -36.838 0.360 1.00 1.00 O +ATOM 74 C3' G A 3 -2.166 -35.396 -1.475 1.00 1.00 C +ATOM 75 O3' G A 3 -2.907 -35.409 -2.702 1.00 1.00 O +ATOM 76 C2' G A 3 -3.060 -34.896 -0.352 1.00 1.00 C +ATOM 77 O2' G A 3 -4.444 -34.973 -0.709 1.00 1.00 O +ATOM 78 C1' G A 3 -2.732 -35.812 0.825 1.00 1.00 C +ATOM 79 N9 G A 3 -2.104 -35.122 1.968 1.00 1.00 N +ATOM 80 C8 G A 3 -0.776 -34.956 2.266 1.00 1.00 C +ATOM 81 N7 G A 3 -0.561 -34.307 3.376 1.00 1.00 N +ATOM 82 C5 G A 3 -1.838 -34.019 3.848 1.00 1.00 C +ATOM 83 C6 G A 3 -2.238 -33.325 5.024 1.00 1.00 C +ATOM 84 O6 G A 3 -1.529 -32.822 5.894 1.00 1.00 O +ATOM 85 N1 G A 3 -3.621 -33.254 5.127 1.00 1.00 N +ATOM 86 C2 G A 3 -4.510 -33.781 4.215 1.00 1.00 C +ATOM 87 N2 G A 3 -5.803 -33.608 4.483 1.00 1.00 N +ATOM 88 N3 G A 3 -4.136 -34.434 3.110 1.00 1.00 N +ATOM 89 C4 G A 3 -2.789 -34.514 2.993 1.00 1.00 C +ATOM 90 H5' G A 3 -0.205 -38.219 -1.034 1.00 1.00 H +ATOM 91 H5'' G A 3 -0.596 -37.586 -2.646 1.00 1.00 H +ATOM 92 H4' G A 3 -2.620 -37.483 -1.421 1.00 1.00 H +ATOM 93 H3' G A 3 -1.262 -34.790 -1.559 1.00 1.00 H +ATOM 94 H2' G A 3 -2.784 -33.873 -0.096 1.00 1.00 H +ATOM 95 HO2' G A 3 -4.951 -34.920 0.104 1.00 1.00 H +ATOM 96 H1' G A 3 -3.657 -36.278 1.167 1.00 1.00 H +ATOM 97 H8 G A 3 0.027 -35.330 1.632 1.00 1.00 H +ATOM 98 H1 G A 3 -3.982 -32.774 5.938 1.00 1.00 H +ATOM 99 H21 G A 3 -6.081 -33.114 5.320 1.00 1.00 H +ATOM 100 H22 G A 3 -6.505 -33.971 3.854 1.00 1.00 H +ATOM 101 P A A 4 -3.220 -34.037 -3.485 1.00 1.00 P +ATOM 102 OP1 A A 4 -3.501 -34.369 -4.899 1.00 1.00 O +ATOM 103 OP2 A A 4 -2.158 -33.061 -3.153 1.00 1.00 O +ATOM 104 O5' A A 4 -4.594 -33.535 -2.805 1.00 1.00 O +ATOM 105 C5' A A 4 -5.843 -34.162 -3.121 1.00 1.00 C +ATOM 106 C4' A A 4 -7.005 -33.517 -2.366 1.00 1.00 C +ATOM 107 O4' A A 4 -6.860 -33.746 -0.964 1.00 1.00 O +ATOM 108 C3' A A 4 -7.111 -32.010 -2.559 1.00 1.00 C +ATOM 109 O3' A A 4 -8.010 -31.726 -3.636 1.00 1.00 O +ATOM 110 C2' A A 4 -7.704 -31.522 -1.248 1.00 1.00 C +ATOM 111 O2' A A 4 -9.133 -31.455 -1.313 1.00 1.00 O +ATOM 112 C1' A A 4 -7.240 -32.568 -0.238 1.00 1.00 C +ATOM 113 N9 A A 4 -6.073 -32.145 0.553 1.00 1.00 N +ATOM 114 C8 A A 4 -4.750 -32.153 0.195 1.00 1.00 C +ATOM 115 N7 A A 4 -3.949 -31.714 1.125 1.00 1.00 N +ATOM 116 C5 A A 4 -4.802 -31.392 2.176 1.00 1.00 C +ATOM 117 C6 A A 4 -4.572 -30.873 3.460 1.00 1.00 C +ATOM 118 N6 A A 4 -3.355 -30.573 3.917 1.00 1.00 N +ATOM 119 N1 A A 4 -5.642 -30.675 4.247 1.00 1.00 N +ATOM 120 C2 A A 4 -6.850 -30.974 3.783 1.00 1.00 C +ATOM 121 N3 A A 4 -7.195 -31.465 2.602 1.00 1.00 N +ATOM 122 C4 A A 4 -6.099 -31.653 1.836 1.00 1.00 C +ATOM 123 H5' A A 4 -5.790 -35.218 -2.856 1.00 1.00 H +ATOM 124 H5'' A A 4 -6.024 -34.073 -4.193 1.00 1.00 H +ATOM 125 H4' A A 4 -7.935 -33.977 -2.694 1.00 1.00 H +ATOM 126 H3' A A 4 -6.128 -31.568 -2.732 1.00 1.00 H +ATOM 127 H2' A A 4 -7.285 -30.548 -0.989 1.00 1.00 H +ATOM 128 HO2' A A 4 -9.469 -32.338 -1.143 1.00 1.00 H +ATOM 129 H1' A A 4 -8.062 -32.807 0.436 1.00 1.00 H +ATOM 130 H8 A A 4 -4.399 -32.495 -0.780 1.00 1.00 H +ATOM 131 H61 A A 4 -3.246 -30.204 4.846 1.00 1.00 H +ATOM 132 H62 A A 4 -2.545 -30.719 3.333 1.00 1.00 H +ATOM 133 H2 A A 4 -7.675 -30.790 4.472 1.00 1.00 H +ATOM 134 P U A 5 -7.767 -30.456 -4.598 1.00 1.00 P +ATOM 135 OP1 U A 5 -8.845 -30.433 -5.612 1.00 1.00 O +ATOM 136 OP2 U A 5 -6.350 -30.465 -5.027 1.00 1.00 O +ATOM 137 O5' U A 5 -7.983 -29.210 -3.603 1.00 1.00 O +ATOM 138 C5' U A 5 -9.261 -28.963 -3.011 1.00 1.00 C +ATOM 139 C4' U A 5 -9.154 -27.976 -1.853 1.00 1.00 C +ATOM 140 O4' U A 5 -8.328 -28.524 -0.832 1.00 1.00 O +ATOM 141 C3' U A 5 -8.548 -26.635 -2.233 1.00 1.00 C +ATOM 142 O3' U A 5 -9.594 -25.727 -2.596 1.00 1.00 O +ATOM 143 C2' U A 5 -7.861 -26.172 -0.955 1.00 1.00 C +ATOM 144 O2' U A 5 -8.700 -25.293 -0.201 1.00 1.00 O +ATOM 145 C1' U A 5 -7.592 -27.472 -0.192 1.00 1.00 C +ATOM 146 N1 U A 5 -6.169 -27.875 -0.174 1.00 1.00 N +ATOM 147 C2 U A 5 -5.412 -27.521 0.927 1.00 1.00 C +ATOM 148 O2 U A 5 -5.887 -26.893 1.872 1.00 1.00 O +ATOM 149 N3 U A 5 -4.086 -27.914 0.905 1.00 1.00 N +ATOM 150 C4 U A 5 -3.460 -28.621 -0.108 1.00 1.00 C +ATOM 151 O4 U A 5 -2.271 -28.919 -0.022 1.00 1.00 O +ATOM 152 C5 U A 5 -4.326 -28.950 -1.218 1.00 1.00 C +ATOM 153 C6 U A 5 -5.628 -28.575 -1.219 1.00 1.00 C +ATOM 154 H5' U A 5 -9.671 -29.903 -2.642 1.00 1.00 H +ATOM 155 H5'' U A 5 -9.931 -28.553 -3.768 1.00 1.00 H +ATOM 156 H4' U A 5 -10.147 -27.811 -1.438 1.00 1.00 H +ATOM 157 H3' U A 5 -7.825 -26.752 -3.042 1.00 1.00 H +ATOM 158 H2' U A 5 -6.914 -25.685 -1.199 1.00 1.00 H +ATOM 159 HO2' U A 5 -8.129 -24.764 0.361 1.00 1.00 H +ATOM 160 H1' U A 5 -7.948 -27.362 0.834 1.00 1.00 H +ATOM 161 H3 U A 5 -3.521 -27.662 1.704 1.00 1.00 H +ATOM 162 H5 U A 5 -3.926 -29.506 -2.066 1.00 1.00 H +ATOM 163 H6 U A 5 -6.259 -28.837 -2.068 1.00 1.00 H +ATOM 164 P A A 6 -9.285 -24.420 -3.485 1.00 1.00 P +ATOM 165 OP1 A A 6 -10.464 -24.151 -4.338 1.00 1.00 O +ATOM 166 OP2 A A 6 -7.950 -24.584 -4.102 1.00 1.00 O +ATOM 167 O5' A A 6 -9.189 -23.256 -2.376 1.00 1.00 O +ATOM 168 C5' A A 6 -9.974 -23.331 -1.182 1.00 1.00 C +ATOM 169 C4' A A 6 -9.850 -22.064 -0.345 1.00 1.00 C +ATOM 170 O4' A A 6 -8.481 -21.880 0.038 1.00 1.00 O +ATOM 171 C3' A A 6 -10.303 -20.795 -1.072 1.00 1.00 C +ATOM 172 O3' A A 6 -11.249 -20.085 -0.259 1.00 1.00 O +ATOM 173 C2' A A 6 -9.035 -19.967 -1.228 1.00 1.00 C +ATOM 174 O2' A A 6 -9.300 -18.572 -1.056 1.00 1.00 O +ATOM 175 C1' A A 6 -8.133 -20.509 -0.134 1.00 1.00 C +ATOM 176 N9 A A 6 -6.690 -20.436 -0.439 1.00 1.00 N +ATOM 177 C8 A A 6 -6.026 -20.846 -1.566 1.00 1.00 C +ATOM 178 N7 A A 6 -4.737 -20.643 -1.523 1.00 1.00 N +ATOM 179 C5 A A 6 -4.535 -20.056 -0.278 1.00 1.00 C +ATOM 180 C6 A A 6 -3.381 -19.597 0.378 1.00 1.00 C +ATOM 181 N6 A A 6 -2.161 -19.667 -0.155 1.00 1.00 N +ATOM 182 N1 A A 6 -3.538 -19.067 1.604 1.00 1.00 N +ATOM 183 C2 A A 6 -4.755 -19.003 2.131 1.00 1.00 C +ATOM 184 N3 A A 6 -5.910 -19.398 1.617 1.00 1.00 N +ATOM 185 C4 A A 6 -5.720 -19.924 0.389 1.00 1.00 C +ATOM 186 H5' A A 6 -9.635 -24.182 -0.589 1.00 1.00 H +ATOM 187 H5'' A A 6 -11.020 -23.479 -1.449 1.00 1.00 H +ATOM 188 H4' A A 6 -10.446 -22.181 0.559 1.00 1.00 H +ATOM 189 H3' A A 6 -10.730 -21.036 -2.048 1.00 1.00 H +ATOM 190 H2' A A 6 -8.586 -20.157 -2.206 1.00 1.00 H +ATOM 191 HO2' A A 6 -9.312 -18.395 -0.111 1.00 1.00 H +ATOM 192 H1' A A 6 -8.330 -19.973 0.791 1.00 1.00 H +ATOM 193 H8 A A 6 -6.528 -21.297 -2.422 1.00 1.00 H +ATOM 194 H61 A A 6 -1.365 -19.321 0.362 1.00 1.00 H +ATOM 195 H62 A A 6 -2.030 -20.062 -1.074 1.00 1.00 H +ATOM 196 H2 A A 6 -4.812 -18.560 3.125 1.00 1.00 H +ATOM 197 P U A 7 -10.893 -19.641 1.252 1.00 1.00 P +ATOM 198 OP1 U A 7 -9.980 -20.646 1.840 1.00 1.00 O +ATOM 199 OP2 U A 7 -12.157 -19.303 1.945 1.00 1.00 O +ATOM 200 O5' U A 7 -10.066 -18.280 1.032 1.00 1.00 O +ATOM 201 C5' U A 7 -9.256 -17.737 2.073 1.00 1.00 C +ATOM 202 C4' U A 7 -8.372 -16.600 1.562 1.00 1.00 C +ATOM 203 O4' U A 7 -7.759 -16.973 0.319 1.00 1.00 O +ATOM 204 C3' U A 7 -9.135 -15.286 1.324 1.00 1.00 C +ATOM 205 O3' U A 7 -8.489 -14.203 2.008 1.00 1.00 O +ATOM 206 C2' U A 7 -9.033 -15.058 -0.180 1.00 1.00 C +ATOM 207 O2' U A 7 -8.869 -13.669 -0.491 1.00 1.00 O +ATOM 208 C1' U A 7 -7.806 -15.859 -0.573 1.00 1.00 C +ATOM 209 N1 U A 7 -7.823 -16.390 -1.954 1.00 1.00 N +ATOM 210 C2 U A 7 -8.420 -15.620 -2.934 1.00 1.00 C +ATOM 211 O2 U A 7 -8.885 -14.509 -2.699 1.00 1.00 O +ATOM 212 N3 U A 7 -8.464 -16.176 -4.200 1.00 1.00 N +ATOM 213 C4 U A 7 -7.969 -17.416 -4.566 1.00 1.00 C +ATOM 214 O4 U A 7 -8.065 -17.812 -5.726 1.00 1.00 O +ATOM 215 C5 U A 7 -7.361 -18.151 -3.480 1.00 1.00 C +ATOM 216 C6 U A 7 -7.307 -17.628 -2.230 1.00 1.00 C +ATOM 217 H5' U A 7 -8.624 -18.523 2.486 1.00 1.00 H +ATOM 218 H5'' U A 7 -9.905 -17.355 2.863 1.00 1.00 H +ATOM 219 H4' U A 7 -7.586 -16.432 2.287 1.00 1.00 H +ATOM 220 H3' U A 7 -10.179 -15.380 1.630 1.00 1.00 H +ATOM 221 H2' U A 7 -9.913 -15.467 -0.678 1.00 1.00 H +ATOM 222 HO2' U A 7 -8.062 -13.584 -1.006 1.00 1.00 H +ATOM 223 H1' U A 7 -6.921 -15.241 -0.436 1.00 1.00 H +ATOM 224 H3 U A 7 -8.897 -15.626 -4.927 1.00 1.00 H +ATOM 225 H5 U A 7 -6.942 -19.140 -3.667 1.00 1.00 H +ATOM 226 H6 U A 7 -6.843 -18.205 -1.430 1.00 1.00 H +ATOM 227 P G A 8 -8.052 -14.338 3.554 1.00 1.00 P +ATOM 228 OP1 G A 8 -9.053 -15.177 4.249 1.00 1.00 O +ATOM 229 OP2 G A 8 -7.728 -12.989 4.066 1.00 1.00 O +ATOM 230 O5' G A 8 -6.685 -15.187 3.434 1.00 1.00 O +ATOM 231 C5' G A 8 -5.567 -14.906 4.279 1.00 1.00 C +ATOM 232 C4' G A 8 -4.386 -14.355 3.484 1.00 1.00 C +ATOM 233 O4' G A 8 -3.756 -15.395 2.739 1.00 1.00 O +ATOM 234 C3' G A 8 -4.767 -13.269 2.493 1.00 1.00 C +ATOM 235 O3' G A 8 -4.642 -11.990 3.120 1.00 1.00 O +ATOM 236 C2' G A 8 -3.741 -13.415 1.378 1.00 1.00 C +ATOM 237 O2' G A 8 -2.631 -12.528 1.565 1.00 1.00 O +ATOM 238 C1' G A 8 -3.308 -14.879 1.476 1.00 1.00 C +ATOM 239 N9 G A 8 -3.883 -15.743 0.432 1.00 1.00 N +ATOM 240 C8 G A 8 -4.972 -16.571 0.522 1.00 1.00 C +ATOM 241 N7 G A 8 -5.242 -17.213 -0.578 1.00 1.00 N +ATOM 242 C5 G A 8 -4.261 -16.786 -1.467 1.00 1.00 C +ATOM 243 C6 G A 8 -4.048 -17.147 -2.826 1.00 1.00 C +ATOM 244 O6 G A 8 -4.699 -17.926 -3.519 1.00 1.00 O +ATOM 245 N1 G A 8 -2.949 -16.491 -3.361 1.00 1.00 N +ATOM 246 C2 G A 8 -2.151 -15.597 -2.678 1.00 1.00 C +ATOM 247 N2 G A 8 -1.137 -15.069 -3.365 1.00 1.00 N +ATOM 248 N3 G A 8 -2.350 -15.253 -1.399 1.00 1.00 N +ATOM 249 C4 G A 8 -3.421 -15.884 -0.859 1.00 1.00 C +ATOM 250 H5' G A 8 -5.260 -15.826 4.776 1.00 1.00 H +ATOM 251 H5'' G A 8 -5.865 -14.178 5.034 1.00 1.00 H +ATOM 252 H4' G A 8 -3.658 -13.946 4.183 1.00 1.00 H +ATOM 253 H3' G A 8 -5.777 -13.428 2.112 1.00 1.00 H +ATOM 254 H2' G A 8 -4.217 -13.236 0.410 1.00 1.00 H +ATOM 255 HO2' G A 8 -2.251 -12.361 0.699 1.00 1.00 H +ATOM 256 H1' G A 8 -2.223 -14.937 1.425 1.00 1.00 H +ATOM 257 H8 G A 8 -5.557 -16.685 1.435 1.00 1.00 H +ATOM 258 H1 G A 8 -2.735 -16.697 -4.326 1.00 1.00 H +ATOM 259 H21 G A 8 -0.990 -15.332 -4.329 1.00 1.00 H +ATOM 260 H22 G A 8 -0.515 -14.408 -2.920 1.00 1.00 H +ATOM 261 P G A 9 -5.528 -10.747 2.619 1.00 1.00 P +ATOM 262 OP1 G A 9 -5.622 -9.771 3.728 1.00 1.00 O +ATOM 263 OP2 G A 9 -6.762 -11.275 1.993 1.00 1.00 O +ATOM 264 O5' G A 9 -4.607 -10.110 1.465 1.00 1.00 O +ATOM 265 C5' G A 9 -4.886 -10.371 0.089 1.00 1.00 C +ATOM 266 C4' G A 9 -3.603 -10.639 -0.700 1.00 1.00 C +ATOM 267 O4' G A 9 -3.475 -12.046 -0.954 1.00 1.00 O +ATOM 268 C3' G A 9 -3.540 -9.926 -2.047 1.00 1.00 C +ATOM 269 O3' G A 9 -2.761 -8.734 -1.922 1.00 1.00 O +ATOM 270 C2' G A 9 -2.823 -10.912 -2.949 1.00 1.00 C +ATOM 271 O2' G A 9 -1.406 -10.703 -2.931 1.00 1.00 O +ATOM 272 C1' G A 9 -3.190 -12.257 -2.343 1.00 1.00 C +ATOM 273 N9 G A 9 -4.377 -12.877 -2.951 1.00 1.00 N +ATOM 274 C8 G A 9 -5.556 -13.244 -2.352 1.00 1.00 C +ATOM 275 N7 G A 9 -6.422 -13.770 -3.171 1.00 1.00 N +ATOM 276 C5 G A 9 -5.774 -13.753 -4.403 1.00 1.00 C +ATOM 277 C6 G A 9 -6.225 -14.199 -5.677 1.00 1.00 C +ATOM 278 O6 G A 9 -7.307 -14.705 -5.970 1.00 1.00 O +ATOM 279 N1 G A 9 -5.261 -14.000 -6.657 1.00 1.00 N +ATOM 280 C2 G A 9 -4.019 -13.442 -6.443 1.00 1.00 C +ATOM 281 N2 G A 9 -3.227 -13.333 -7.510 1.00 1.00 N +ATOM 282 N3 G A 9 -3.593 -13.022 -5.246 1.00 1.00 N +ATOM 283 C4 G A 9 -4.520 -13.208 -4.278 1.00 1.00 C +ATOM 284 H5' G A 9 -5.397 -9.507 -0.336 1.00 1.00 H +ATOM 285 H5'' G A 9 -5.539 -11.242 0.017 1.00 1.00 H +ATOM 286 H4' G A 9 -2.752 -10.323 -0.098 1.00 1.00 H +ATOM 287 H3' G A 9 -4.542 -9.711 -2.425 1.00 1.00 H +ATOM 288 H2' G A 9 -3.213 -10.842 -3.967 1.00 1.00 H +ATOM 289 HO2' G A 9 -1.259 -9.754 -2.961 1.00 1.00 H +ATOM 290 H1' G A 9 -2.344 -12.937 -2.438 1.00 1.00 H +ATOM 291 H8 G A 9 -5.749 -13.110 -1.289 1.00 1.00 H +ATOM 292 H1 G A 9 -5.510 -14.293 -7.590 1.00 1.00 H +ATOM 293 H21 G A 9 -3.550 -13.651 -8.411 1.00 1.00 H +ATOM 294 H22 G A 9 -2.305 -12.932 -7.416 1.00 1.00 H +ATOM 295 P A A 10 -3.373 -7.312 -2.361 1.00 1.00 P +ATOM 296 OP1 A A 10 -2.371 -6.267 -2.058 1.00 1.00 O +ATOM 297 OP2 A A 10 -4.741 -7.206 -1.808 1.00 1.00 O +ATOM 298 O5' A A 10 -3.484 -7.452 -3.961 1.00 1.00 O +ATOM 299 C5' A A 10 -2.305 -7.506 -4.767 1.00 1.00 C +ATOM 300 C4' A A 10 -2.645 -7.540 -6.253 1.00 1.00 C +ATOM 301 O4' A A 10 -2.864 -8.881 -6.675 1.00 1.00 O +ATOM 302 C3' A A 10 -3.895 -6.763 -6.624 1.00 1.00 C +ATOM 303 O3' A A 10 -3.556 -5.408 -6.930 1.00 1.00 O +ATOM 304 C2' A A 10 -4.396 -7.472 -7.871 1.00 1.00 C +ATOM 305 O2' A A 10 -3.927 -6.829 -9.062 1.00 1.00 O +ATOM 306 C1' A A 10 -3.825 -8.883 -7.739 1.00 1.00 C +ATOM 307 N9 A A 10 -4.834 -9.903 -7.415 1.00 1.00 N +ATOM 308 C8 A A 10 -5.259 -10.337 -6.184 1.00 1.00 C +ATOM 309 N7 A A 10 -6.169 -11.270 -6.237 1.00 1.00 N +ATOM 310 C5 A A 10 -6.362 -11.468 -7.601 1.00 1.00 C +ATOM 311 C6 A A 10 -7.203 -12.331 -8.325 1.00 1.00 C +ATOM 312 N6 A A 10 -8.040 -13.190 -7.745 1.00 1.00 N +ATOM 313 N1 A A 10 -7.142 -12.268 -9.666 1.00 1.00 N +ATOM 314 C2 A A 10 -6.306 -11.410 -10.238 1.00 1.00 C +ATOM 315 N3 A A 10 -5.470 -10.553 -9.671 1.00 1.00 N +ATOM 316 C4 A A 10 -5.553 -10.639 -8.326 1.00 1.00 C +ATOM 317 H5' A A 10 -1.742 -8.403 -4.512 1.00 1.00 H +ATOM 318 H5'' A A 10 -1.690 -6.630 -4.560 1.00 1.00 H +ATOM 319 H4' A A 10 -1.803 -7.138 -6.814 1.00 1.00 H +ATOM 320 H3' A A 10 -4.635 -6.816 -5.823 1.00 1.00 H +ATOM 321 H2' A A 10 -5.486 -7.514 -7.861 1.00 1.00 H +ATOM 322 HO2' A A 10 -4.417 -7.201 -9.799 1.00 1.00 H +ATOM 323 H1' A A 10 -3.331 -9.158 -8.670 1.00 1.00 H +ATOM 324 H8 A A 10 -4.870 -9.938 -5.247 1.00 1.00 H +ATOM 325 H61 A A 10 -8.626 -13.790 -8.315 1.00 1.00 H +ATOM 326 H62 A A 10 -8.092 -13.245 -6.738 1.00 1.00 H +ATOM 327 H2 A A 10 -6.308 -11.411 -11.328 1.00 1.00 H +ATOM 328 P A A 11 -4.688 -4.263 -6.916 1.00 1.00 P +ATOM 329 OP1 A A 11 -4.020 -2.949 -7.049 1.00 1.00 O +ATOM 330 OP2 A A 11 -5.593 -4.520 -5.772 1.00 1.00 O +ATOM 331 O5' A A 11 -5.500 -4.554 -8.276 1.00 1.00 O +ATOM 332 C5' A A 11 -4.862 -4.405 -9.547 1.00 1.00 C +ATOM 333 C4' A A 11 -5.797 -4.785 -10.691 1.00 1.00 C +ATOM 334 O4' A A 11 -6.096 -6.179 -10.638 1.00 1.00 O +ATOM 335 C3' A A 11 -7.131 -4.059 -10.678 1.00 1.00 C +ATOM 336 O3' A A 11 -7.030 -2.833 -11.413 1.00 1.00 O +ATOM 337 C2' A A 11 -8.052 -5.028 -11.398 1.00 1.00 C +ATOM 338 O2' A A 11 -8.096 -4.775 -12.806 1.00 1.00 O +ATOM 339 C1' A A 11 -7.444 -6.391 -11.086 1.00 1.00 C +ATOM 340 N9 A A 11 -8.161 -7.132 -10.036 1.00 1.00 N +ATOM 341 C8 A A 11 -8.057 -7.017 -8.673 1.00 1.00 C +ATOM 342 N7 A A 11 -8.843 -7.824 -8.014 1.00 1.00 N +ATOM 343 C5 A A 11 -9.516 -8.522 -9.013 1.00 1.00 C +ATOM 344 C6 A A 11 -10.495 -9.528 -8.972 1.00 1.00 C +ATOM 345 N6 A A 11 -10.984 -10.026 -7.837 1.00 1.00 N +ATOM 346 N1 A A 11 -10.946 -9.998 -10.148 1.00 1.00 N +ATOM 347 C2 A A 11 -10.455 -9.498 -11.276 1.00 1.00 C +ATOM 348 N3 A A 11 -9.538 -8.556 -11.444 1.00 1.00 N +ATOM 349 C4 A A 11 -9.106 -8.106 -10.247 1.00 1.00 C +ATOM 350 H5' A A 11 -3.980 -5.045 -9.581 1.00 1.00 H +ATOM 351 H5'' A A 11 -4.552 -3.366 -9.670 1.00 1.00 H +ATOM 352 H4' A A 11 -5.296 -4.581 -11.636 1.00 1.00 H +ATOM 353 H3' A A 11 -7.469 -3.885 -9.655 1.00 1.00 H +ATOM 354 H2' A A 11 -9.047 -4.974 -10.965 1.00 1.00 H +ATOM 355 HO2' A A 11 -9.022 -4.726 -13.059 1.00 1.00 H +ATOM 356 H1' A A 11 -7.431 -6.990 -11.997 1.00 1.00 H +ATOM 357 H8 A A 11 -7.382 -6.315 -8.184 1.00 1.00 H +ATOM 358 H61 A A 11 -11.689 -10.750 -7.866 1.00 1.00 H +ATOM 359 H62 A A 11 -10.655 -9.681 -6.949 1.00 1.00 H +ATOM 360 H2 A A 11 -10.864 -9.922 -12.194 1.00 1.00 H +ATOM 361 P G A 12 -7.894 -1.542 -10.984 1.00 1.00 P +ATOM 362 OP1 G A 12 -7.239 -0.342 -11.551 1.00 1.00 O +ATOM 363 OP2 G A 12 -8.155 -1.622 -9.529 1.00 1.00 O +ATOM 364 O5' G A 12 -9.290 -1.765 -11.760 1.00 1.00 O +ATOM 365 C5' G A 12 -9.422 -1.417 -13.141 1.00 1.00 C +ATOM 366 C4' G A 12 -10.676 -2.034 -13.760 1.00 1.00 C +ATOM 367 O4' G A 12 -10.701 -3.437 -13.506 1.00 1.00 O +ATOM 368 C3' G A 12 -11.988 -1.474 -13.227 1.00 1.00 C +ATOM 369 O3' G A 12 -12.404 -0.364 -14.030 1.00 1.00 O +ATOM 370 C2' G A 12 -12.955 -2.636 -13.398 1.00 1.00 C +ATOM 371 O2' G A 12 -13.602 -2.599 -14.675 1.00 1.00 O +ATOM 372 C1' G A 12 -12.054 -3.852 -13.260 1.00 1.00 C +ATOM 373 N9 G A 12 -12.097 -4.451 -11.920 1.00 1.00 N +ATOM 374 C8 G A 12 -11.388 -4.103 -10.799 1.00 1.00 C +ATOM 375 N7 G A 12 -11.641 -4.848 -9.760 1.00 1.00 N +ATOM 376 C5 G A 12 -12.589 -5.757 -10.223 1.00 1.00 C +ATOM 377 C6 G A 12 -13.243 -6.820 -9.539 1.00 1.00 C +ATOM 378 O6 G A 12 -13.109 -7.171 -8.369 1.00 1.00 O +ATOM 379 N1 G A 12 -14.126 -7.493 -10.372 1.00 1.00 N +ATOM 380 C2 G A 12 -14.354 -7.187 -11.697 1.00 1.00 C +ATOM 381 N2 G A 12 -15.243 -7.948 -12.335 1.00 1.00 N +ATOM 382 N3 G A 12 -13.740 -6.191 -12.342 1.00 1.00 N +ATOM 383 C4 G A 12 -12.874 -5.522 -11.544 1.00 1.00 C +ATOM 384 H5' G A 12 -8.545 -1.774 -13.684 1.00 1.00 H +ATOM 385 H5'' G A 12 -9.477 -0.333 -13.232 1.00 1.00 H +ATOM 386 H4' G A 12 -10.645 -1.884 -14.837 1.00 1.00 H +ATOM 387 H3' G A 12 -11.896 -1.195 -12.176 1.00 1.00 H +ATOM 388 H2' G A 12 -13.689 -2.642 -12.591 1.00 1.00 H +ATOM 389 HO2' G A 12 -12.914 -2.595 -15.345 1.00 1.00 H +ATOM 390 H1' G A 12 -12.342 -4.601 -13.997 1.00 1.00 H +ATOM 391 H8 G A 12 -10.677 -3.276 -10.779 1.00 1.00 H +ATOM 392 H1 G A 12 -14.629 -8.263 -9.956 1.00 1.00 H +ATOM 393 H21 G A 12 -15.707 -8.699 -11.846 1.00 1.00 H +ATOM 394 H22 G A 12 -15.453 -7.771 -13.307 1.00 1.00 H +ATOM 395 P A A 13 -13.355 0.784 -13.418 1.00 1.00 P +ATOM 396 OP1 A A 13 -13.536 1.829 -14.451 1.00 1.00 O +ATOM 397 OP2 A A 13 -12.842 1.151 -12.080 1.00 1.00 O +ATOM 398 O5' A A 13 -14.763 0.027 -13.227 1.00 1.00 O +ATOM 399 C5' A A 13 -15.593 -0.266 -14.354 1.00 1.00 C +ATOM 400 C4' A A 13 -16.822 -1.077 -13.950 1.00 1.00 C +ATOM 401 O4' A A 13 -16.419 -2.353 -13.458 1.00 1.00 O +ATOM 402 C3' A A 13 -17.664 -0.442 -12.856 1.00 1.00 C +ATOM 403 O3' A A 13 -18.643 0.428 -13.439 1.00 1.00 O +ATOM 404 C2' A A 13 -18.338 -1.647 -12.213 1.00 1.00 C +ATOM 405 O2' A A 13 -19.578 -1.964 -12.856 1.00 1.00 O +ATOM 406 C1' A A 13 -17.307 -2.760 -12.404 1.00 1.00 C +ATOM 407 N9 A A 13 -16.484 -3.018 -11.213 1.00 1.00 N +ATOM 408 C8 A A 13 -15.408 -2.316 -10.734 1.00 1.00 C +ATOM 409 N7 A A 13 -14.893 -2.819 -9.646 1.00 1.00 N +ATOM 410 C5 A A 13 -15.685 -3.934 -9.387 1.00 1.00 C +ATOM 411 C6 A A 13 -15.660 -4.901 -8.368 1.00 1.00 C +ATOM 412 N6 A A 13 -14.767 -4.896 -7.377 1.00 1.00 N +ATOM 413 N1 A A 13 -16.591 -5.869 -8.415 1.00 1.00 N +ATOM 414 C2 A A 13 -17.477 -5.869 -9.402 1.00 1.00 C +ATOM 415 N3 A A 13 -17.604 -5.021 -10.412 1.00 1.00 N +ATOM 416 C4 A A 13 -16.657 -4.062 -10.338 1.00 1.00 C +ATOM 417 H5' A A 13 -15.016 -0.832 -15.085 1.00 1.00 H +ATOM 418 H5'' A A 13 -15.918 0.672 -14.806 1.00 1.00 H +ATOM 419 H4' A A 13 -17.445 -1.232 -14.829 1.00 1.00 H +ATOM 420 H3' A A 13 -17.038 0.085 -12.134 1.00 1.00 H +ATOM 421 H2' A A 13 -18.493 -1.465 -11.149 1.00 1.00 H +ATOM 422 HO2' A A 13 -19.520 -1.651 -13.760 1.00 1.00 H +ATOM 423 H1' A A 13 -17.814 -3.682 -12.691 1.00 1.00 H +ATOM 424 H8 A A 13 -15.019 -1.419 -11.217 1.00 1.00 H +ATOM 425 H61 A A 13 -14.799 -5.625 -6.665 1.00 1.00 H +ATOM 426 H62 A A 13 -14.064 -4.174 -7.331 1.00 1.00 H +ATOM 427 H2 A A 13 -18.204 -6.682 -9.380 1.00 1.00 H +ATOM 428 P A A 14 -18.933 1.888 -12.815 1.00 1.00 P +ATOM 429 OP1 A A 14 -19.885 2.588 -13.708 1.00 1.00 O +ATOM 430 OP2 A A 14 -17.634 2.517 -12.486 1.00 1.00 O +ATOM 431 O5' A A 14 -19.695 1.551 -11.437 1.00 1.00 O +ATOM 432 C5' A A 14 -21.090 1.238 -11.440 1.00 1.00 C +ATOM 433 C4' A A 14 -21.536 0.637 -10.110 1.00 1.00 C +ATOM 434 O4' A A 14 -20.809 -0.558 -9.851 1.00 1.00 O +ATOM 435 C3' A A 14 -21.310 1.534 -8.905 1.00 1.00 C +ATOM 436 O3' A A 14 -22.446 2.383 -8.698 1.00 1.00 O +ATOM 437 C2' A A 14 -21.181 0.550 -7.759 1.00 1.00 C +ATOM 438 O2' A A 14 -22.436 0.343 -7.103 1.00 1.00 O +ATOM 439 C1' A A 14 -20.677 -0.724 -8.431 1.00 1.00 C +ATOM 440 N9 A A 14 -19.262 -1.016 -8.145 1.00 1.00 N +ATOM 441 C8 A A 14 -18.139 -0.543 -8.775 1.00 1.00 C +ATOM 442 N7 A A 14 -17.023 -1.009 -8.282 1.00 1.00 N +ATOM 443 C5 A A 14 -17.438 -1.849 -7.253 1.00 1.00 C +ATOM 444 C6 A A 14 -16.733 -2.648 -6.338 1.00 1.00 C +ATOM 445 N6 A A 14 -15.402 -2.731 -6.315 1.00 1.00 N +ATOM 446 N1 A A 14 -17.455 -3.353 -5.452 1.00 1.00 N +ATOM 447 C2 A A 14 -18.780 -3.266 -5.480 1.00 1.00 C +ATOM 448 N3 A A 14 -19.554 -2.556 -6.287 1.00 1.00 N +ATOM 449 C4 A A 14 -18.801 -1.859 -7.163 1.00 1.00 C +ATOM 450 H5' A A 14 -21.293 0.525 -12.240 1.00 1.00 H +ATOM 451 H5'' A A 14 -21.658 2.151 -11.626 1.00 1.00 H +ATOM 452 H4' A A 14 -22.592 0.384 -10.173 1.00 1.00 H +ATOM 453 H3' A A 14 -20.394 2.116 -9.019 1.00 1.00 H +ATOM 454 H2' A A 14 -20.436 0.908 -7.059 1.00 1.00 H +ATOM 455 HO2' A A 14 -22.776 -0.506 -7.394 1.00 1.00 H +ATOM 456 H1' A A 14 -21.285 -1.569 -8.107 1.00 1.00 H +ATOM 457 H8 A A 14 -18.175 0.159 -9.607 1.00 1.00 H +ATOM 458 H61 A A 14 -14.949 -3.318 -5.640 1.00 1.00 H +ATOM 459 H62 A A 14 -14.852 -2.203 -6.980 1.00 1.00 H +ATOM 460 H2 A A 14 -19.304 -3.863 -4.734 1.00 1.00 H +ATOM 461 P C A 15 -22.320 3.718 -7.799 1.00 1.00 P +ATOM 462 OP1 C A 15 -23.596 4.459 -7.895 1.00 1.00 O +ATOM 463 OP2 C A 15 -21.046 4.389 -8.143 1.00 1.00 O +ATOM 464 O5' C A 15 -22.189 3.139 -6.299 1.00 1.00 O +ATOM 465 C5' C A 15 -23.349 2.713 -5.576 1.00 1.00 C +ATOM 466 C4' C A 15 -22.981 2.130 -4.214 1.00 1.00 C +ATOM 467 O4' C A 15 -22.156 0.989 -4.388 1.00 1.00 O +ATOM 468 C3' C A 15 -22.203 3.066 -3.310 1.00 1.00 C +ATOM 469 O3' C A 15 -23.103 3.874 -2.544 1.00 1.00 O +ATOM 470 C2' C A 15 -21.450 2.108 -2.394 1.00 1.00 C +ATOM 471 O2' C A 15 -22.189 1.833 -1.201 1.00 1.00 O +ATOM 472 C1' C A 15 -21.285 0.851 -3.251 1.00 1.00 C +ATOM 473 N1 C A 15 -19.915 0.672 -3.775 1.00 1.00 N +ATOM 474 C2 C A 15 -19.115 -0.301 -3.195 1.00 1.00 C +ATOM 475 O2 C A 15 -19.551 -0.987 -2.273 1.00 1.00 O +ATOM 476 N3 C A 15 -17.851 -0.467 -3.675 1.00 1.00 N +ATOM 477 C4 C A 15 -17.392 0.288 -4.682 1.00 1.00 C +ATOM 478 N4 C A 15 -16.150 0.102 -5.129 1.00 1.00 N +ATOM 479 C5 C A 15 -18.216 1.292 -5.283 1.00 1.00 C +ATOM 480 C6 C A 15 -19.463 1.449 -4.801 1.00 1.00 C +ATOM 481 H5' C A 15 -23.874 1.955 -6.160 1.00 1.00 H +ATOM 482 H5'' C A 15 -24.009 3.568 -5.430 1.00 1.00 H +ATOM 483 H4' C A 15 -23.891 1.819 -3.706 1.00 1.00 H +ATOM 484 H3' C A 15 -21.508 3.678 -3.886 1.00 1.00 H +ATOM 485 H2' C A 15 -20.469 2.521 -2.152 1.00 1.00 H +ATOM 486 HO2' C A 15 -23.117 1.976 -1.398 1.00 1.00 H +ATOM 487 H1' C A 15 -21.576 -0.025 -2.671 1.00 1.00 H +ATOM 488 H41 C A 15 -15.563 -0.606 -4.707 1.00 1.00 H +ATOM 489 H42 C A 15 -15.795 0.667 -5.888 1.00 1.00 H +ATOM 490 H5 C A 15 -17.847 1.907 -6.104 1.00 1.00 H +ATOM 491 H6 C A 15 -20.119 2.205 -5.235 1.00 1.00 H +ATOM 492 P C A 16 -22.604 5.271 -1.918 1.00 1.00 P +ATOM 493 OP1 C A 16 -23.710 5.840 -1.114 1.00 1.00 O +ATOM 494 OP2 C A 16 -21.989 6.070 -3.000 1.00 1.00 O +ATOM 495 O5' C A 16 -21.438 4.796 -0.912 1.00 1.00 O +ATOM 496 C5' C A 16 -21.758 4.008 0.236 1.00 1.00 C +ATOM 497 C4' C A 16 -20.543 3.242 0.759 1.00 1.00 C +ATOM 498 O4' C A 16 -19.934 2.504 -0.296 1.00 1.00 O +ATOM 499 C3' C A 16 -19.446 4.114 1.345 1.00 1.00 C +ATOM 500 O3' C A 16 -19.671 4.292 2.746 1.00 1.00 O +ATOM 501 C2' C A 16 -18.187 3.292 1.140 1.00 1.00 C +ATOM 502 O2' C A 16 -17.818 2.587 2.328 1.00 1.00 O +ATOM 503 C1' C A 16 -18.544 2.330 0.011 1.00 1.00 C +ATOM 504 N1 C A 16 -17.747 2.523 -1.225 1.00 1.00 N +ATOM 505 C2 C A 16 -16.676 1.666 -1.422 1.00 1.00 C +ATOM 506 O2 C A 16 -16.414 0.805 -0.584 1.00 1.00 O +ATOM 507 N3 C A 16 -15.935 1.807 -2.555 1.00 1.00 N +ATOM 508 C4 C A 16 -16.232 2.752 -3.458 1.00 1.00 C +ATOM 509 N4 C A 16 -15.487 2.861 -4.558 1.00 1.00 N +ATOM 510 C5 C A 16 -17.335 3.640 -3.257 1.00 1.00 C +ATOM 511 C6 C A 16 -18.062 3.492 -2.132 1.00 1.00 C +ATOM 512 H5' C A 16 -22.540 3.296 -0.029 1.00 1.00 H +ATOM 513 H5'' C A 16 -22.129 4.665 1.024 1.00 1.00 H +ATOM 514 H4' C A 16 -20.875 2.536 1.517 1.00 1.00 H +ATOM 515 H3' C A 16 -19.383 5.070 0.823 1.00 1.00 H +ATOM 516 H2' C A 16 -17.380 3.946 0.812 1.00 1.00 H +ATOM 517 HO2' C A 16 -18.227 1.719 2.282 1.00 1.00 H +ATOM 518 H1' C A 16 -18.399 1.309 0.372 1.00 1.00 H +ATOM 519 H41 C A 16 -14.701 2.234 -4.703 1.00 1.00 H +ATOM 520 H42 C A 16 -15.701 3.570 -5.245 1.00 1.00 H +ATOM 521 H5 C A 16 -17.579 4.411 -3.991 1.00 1.00 H +ATOM 522 H6 C A 16 -18.908 4.154 -1.946 1.00 1.00 H +ATOM 523 P G A 17 -18.754 5.305 3.598 1.00 1.00 P +ATOM 524 OP1 G A 17 -19.463 5.623 4.857 1.00 1.00 O +ATOM 525 OP2 G A 17 -18.314 6.398 2.701 1.00 1.00 O +ATOM 526 O5' G A 17 -17.470 4.399 3.959 1.00 1.00 O +ATOM 527 C5' G A 17 -17.605 3.237 4.786 1.00 1.00 C +ATOM 528 C4' G A 17 -16.253 2.585 5.071 1.00 1.00 C +ATOM 529 O4' G A 17 -15.710 2.022 3.881 1.00 1.00 O +ATOM 530 C3' G A 17 -15.199 3.535 5.610 1.00 1.00 C +ATOM 531 O3' G A 17 -15.270 3.593 7.037 1.00 1.00 O +ATOM 532 C2' G A 17 -13.891 2.893 5.181 1.00 1.00 C +ATOM 533 O2' G A 17 -13.365 2.043 6.202 1.00 1.00 O +ATOM 534 C1' G A 17 -14.274 2.095 3.939 1.00 1.00 C +ATOM 535 N9 G A 17 -13.817 2.710 2.687 1.00 1.00 N +ATOM 536 C8 G A 17 -14.517 3.527 1.837 1.00 1.00 C +ATOM 537 N7 G A 17 -13.832 3.925 0.802 1.00 1.00 N +ATOM 538 C5 G A 17 -12.586 3.330 0.975 1.00 1.00 C +ATOM 539 C6 G A 17 -11.423 3.401 0.161 1.00 1.00 C +ATOM 540 O6 G A 17 -11.263 4.017 -0.892 1.00 1.00 O +ATOM 541 N1 G A 17 -10.381 2.655 0.694 1.00 1.00 N +ATOM 542 C2 G A 17 -10.446 1.929 1.865 1.00 1.00 C +ATOM 543 N2 G A 17 -9.336 1.279 2.215 1.00 1.00 N +ATOM 544 N3 G A 17 -11.539 1.860 2.632 1.00 1.00 N +ATOM 545 C4 G A 17 -12.567 2.583 2.126 1.00 1.00 C +ATOM 546 H5' G A 17 -18.247 2.515 4.278 1.00 1.00 H +ATOM 547 H5'' G A 17 -18.071 3.524 5.728 1.00 1.00 H +ATOM 548 H4' G A 17 -16.400 1.782 5.791 1.00 1.00 H +ATOM 549 H3' G A 17 -15.308 4.527 5.168 1.00 1.00 H +ATOM 550 H2' G A 17 -13.171 3.665 4.913 1.00 1.00 H +ATOM 551 HO2' G A 17 -13.478 1.138 5.904 1.00 1.00 H +ATOM 552 H1' G A 17 -13.862 1.090 4.016 1.00 1.00 H +ATOM 553 H8 G A 17 -15.553 3.818 2.011 1.00 1.00 H +ATOM 554 H1 G A 17 -9.518 2.659 0.169 1.00 1.00 H +ATOM 555 H21 G A 17 -8.513 1.335 1.631 1.00 1.00 H +ATOM 556 H22 G A 17 -9.319 0.730 3.062 1.00 1.00 H +ATOM 557 P G A 18 -14.599 4.820 7.835 1.00 1.00 P +ATOM 558 OP1 G A 18 -14.911 4.662 9.273 1.00 1.00 O +ATOM 559 OP2 G A 18 -14.950 6.076 7.134 1.00 1.00 O +ATOM 560 O5' G A 18 -13.022 4.551 7.627 1.00 1.00 O +ATOM 561 C5' G A 18 -12.413 3.366 8.150 1.00 1.00 C +ATOM 562 C4' G A 18 -10.927 3.294 7.805 1.00 1.00 C +ATOM 563 O4' G A 18 -10.746 3.160 6.400 1.00 1.00 O +ATOM 564 C3' G A 18 -10.128 4.515 8.220 1.00 1.00 C +ATOM 565 O3' G A 18 -9.648 4.343 9.556 1.00 1.00 O +ATOM 566 C2' G A 18 -8.965 4.533 7.240 1.00 1.00 C +ATOM 567 O2' G A 18 -7.796 3.925 7.802 1.00 1.00 O +ATOM 568 C1' G A 18 -9.486 3.747 6.037 1.00 1.00 C +ATOM 569 N9 G A 18 -9.703 4.576 4.838 1.00 1.00 N +ATOM 570 C8 G A 18 -10.808 5.307 4.486 1.00 1.00 C +ATOM 571 N7 G A 18 -10.690 5.930 3.347 1.00 1.00 N +ATOM 572 C5 G A 18 -9.413 5.589 2.909 1.00 1.00 C +ATOM 573 C6 G A 18 -8.724 5.970 1.724 1.00 1.00 C +ATOM 574 O6 G A 18 -9.116 6.699 0.815 1.00 1.00 O +ATOM 575 N1 G A 18 -7.457 5.406 1.667 1.00 1.00 N +ATOM 576 C2 G A 18 -6.917 4.577 2.628 1.00 1.00 C +ATOM 577 N2 G A 18 -5.682 4.133 2.396 1.00 1.00 N +ATOM 578 N3 G A 18 -7.562 4.217 3.743 1.00 1.00 N +ATOM 579 C4 G A 18 -8.801 4.759 3.816 1.00 1.00 C +ATOM 580 H5' G A 18 -12.917 2.493 7.732 1.00 1.00 H +ATOM 581 H5'' G A 18 -12.528 3.356 9.234 1.00 1.00 H +ATOM 582 H4' G A 18 -10.499 2.417 8.289 1.00 1.00 H +ATOM 583 H3' G A 18 -10.728 5.422 8.127 1.00 1.00 H +ATOM 584 H2' G A 18 -8.756 5.557 6.939 1.00 1.00 H +ATOM 585 HO2' G A 18 -7.972 2.986 7.886 1.00 1.00 H +ATOM 586 H1' G A 18 -8.778 2.955 5.796 1.00 1.00 H +ATOM 587 H8 G A 18 -11.705 5.362 5.102 1.00 1.00 H +ATOM 588 H1 G A 18 -6.905 5.632 0.853 1.00 1.00 H +ATOM 589 H21 G A 18 -5.197 4.407 1.554 1.00 1.00 H +ATOM 590 H22 G A 18 -5.231 3.523 3.063 1.00 1.00 H +ATOM 591 P G A 19 -9.159 5.605 10.425 1.00 1.00 P +ATOM 592 OP1 G A 19 -8.930 5.147 11.813 1.00 1.00 O +ATOM 593 OP2 G A 19 -10.080 6.733 10.162 1.00 1.00 O +ATOM 594 O5' G A 19 -7.730 5.958 9.768 1.00 1.00 O +ATOM 595 C5' G A 19 -6.650 5.019 9.819 1.00 1.00 C +ATOM 596 C4' G A 19 -5.453 5.499 9.000 1.00 1.00 C +ATOM 597 O4' G A 19 -5.800 5.574 7.625 1.00 1.00 O +ATOM 598 C3' G A 19 -4.943 6.874 9.388 1.00 1.00 C +ATOM 599 O3' G A 19 -3.960 6.744 10.422 1.00 1.00 O +ATOM 600 C2' G A 19 -4.303 7.391 8.104 1.00 1.00 C +ATOM 601 O2' G A 19 -2.892 7.152 8.093 1.00 1.00 O +ATOM 602 C1' G A 19 -5.015 6.600 6.999 1.00 1.00 C +ATOM 603 N9 G A 19 -5.927 7.410 6.175 1.00 1.00 N +ATOM 604 C8 G A 19 -7.222 7.777 6.437 1.00 1.00 C +ATOM 605 N7 G A 19 -7.767 8.501 5.500 1.00 1.00 N +ATOM 606 C5 G A 19 -6.762 8.625 4.544 1.00 1.00 C +ATOM 607 C6 G A 19 -6.772 9.305 3.295 1.00 1.00 C +ATOM 608 O6 G A 19 -7.688 9.945 2.781 1.00 1.00 O +ATOM 609 N1 G A 19 -5.555 9.184 2.638 1.00 1.00 N +ATOM 610 C2 G A 19 -4.463 8.493 3.120 1.00 1.00 C +ATOM 611 N2 G A 19 -3.379 8.490 2.345 1.00 1.00 N +ATOM 612 N3 G A 19 -4.452 7.852 4.294 1.00 1.00 N +ATOM 613 C4 G A 19 -5.631 7.960 4.949 1.00 1.00 C +ATOM 614 H5' G A 19 -6.991 4.061 9.424 1.00 1.00 H +ATOM 615 H5'' G A 19 -6.342 4.886 10.856 1.00 1.00 H +ATOM 616 H4' G A 19 -4.644 4.779 9.109 1.00 1.00 H +ATOM 617 H3' G A 19 -5.766 7.520 9.700 1.00 1.00 H +ATOM 618 H2' G A 19 -4.515 8.456 7.990 1.00 1.00 H +ATOM 619 HO2' G A 19 -2.622 7.093 7.173 1.00 1.00 H +ATOM 620 H1' G A 19 -4.271 6.137 6.350 1.00 1.00 H +ATOM 621 H8 G A 19 -7.749 7.491 7.347 1.00 1.00 H +ATOM 622 H1 G A 19 -5.485 9.644 1.742 1.00 1.00 H +ATOM 623 H21 G A 19 -3.390 8.974 1.460 1.00 1.00 H +ATOM 624 H22 G A 19 -2.546 8.000 2.643 1.00 1.00 H +ATOM 625 P G A 20 -3.793 7.881 11.549 1.00 1.00 P +ATOM 626 OP1 G A 20 -3.072 7.292 12.698 1.00 1.00 O +ATOM 627 OP2 G A 20 -5.111 8.527 11.755 1.00 1.00 O +ATOM 628 O5' G A 20 -2.818 8.942 10.835 1.00 1.00 O +ATOM 629 C5' G A 20 -2.954 10.339 11.101 1.00 1.00 C +ATOM 630 C4' G A 20 -2.515 11.181 9.907 1.00 1.00 C +ATOM 631 O4' G A 20 -2.990 10.586 8.695 1.00 1.00 O +ATOM 632 C3' G A 20 -3.027 12.614 9.944 1.00 1.00 C +ATOM 633 O3' G A 20 -2.010 13.468 10.476 1.00 1.00 O +ATOM 634 C2' G A 20 -3.271 12.951 8.483 1.00 1.00 C +ATOM 635 O2' G A 20 -2.120 13.566 7.896 1.00 1.00 O +ATOM 636 C1' G A 20 -3.559 11.592 7.848 1.00 1.00 C +ATOM 637 N9 G A 20 -4.994 11.284 7.709 1.00 1.00 N +ATOM 638 C8 G A 20 -5.848 10.765 8.647 1.00 1.00 C +ATOM 639 N7 G A 20 -7.070 10.607 8.223 1.00 1.00 N +ATOM 640 C5 G A 20 -7.027 11.053 6.905 1.00 1.00 C +ATOM 641 C6 G A 20 -8.064 11.121 5.935 1.00 1.00 C +ATOM 642 O6 G A 20 -9.244 10.797 6.056 1.00 1.00 O +ATOM 643 N1 G A 20 -7.602 11.631 4.731 1.00 1.00 N +ATOM 644 C2 G A 20 -6.306 12.027 4.483 1.00 1.00 C +ATOM 645 N2 G A 20 -6.056 12.489 3.258 1.00 1.00 N +ATOM 646 N3 G A 20 -5.326 11.966 5.395 1.00 1.00 N +ATOM 647 C4 G A 20 -5.759 11.469 6.580 1.00 1.00 C +ATOM 648 H5' G A 20 -2.339 10.598 11.963 1.00 1.00 H +ATOM 649 H5'' G A 20 -3.996 10.557 11.330 1.00 1.00 H +ATOM 650 H4' G A 20 -1.427 11.200 9.874 1.00 1.00 H +ATOM 651 H3' G A 20 -3.951 12.686 10.520 1.00 1.00 H +ATOM 652 H2' G A 20 -4.146 13.599 8.389 1.00 1.00 H +ATOM 653 HO2' G A 20 -1.468 13.675 8.592 1.00 1.00 H +ATOM 654 H1' G A 20 -3.087 11.546 6.866 1.00 1.00 H +ATOM 655 H8 G A 20 -5.534 10.503 9.658 1.00 1.00 H +ATOM 656 H1 G A 20 -8.285 11.709 3.991 1.00 1.00 H +ATOM 657 H21 G A 20 -6.798 12.534 2.574 1.00 1.00 H +ATOM 658 H22 G A 20 -5.129 12.792 3.016 1.00 1.00 H +ATOM 659 P A A 21 -2.343 14.493 11.674 1.00 1.00 P +ATOM 660 OP1 A A 21 -1.067 15.054 12.170 1.00 1.00 O +ATOM 661 OP2 A A 21 -3.271 13.823 12.613 1.00 1.00 O +ATOM 662 O5' A A 21 -3.149 15.665 10.920 1.00 1.00 O +ATOM 663 C5' A A 21 -4.096 16.470 11.628 1.00 1.00 C +ATOM 664 C4' A A 21 -4.494 17.702 10.821 1.00 1.00 C +ATOM 665 O4' A A 21 -3.363 18.572 10.687 1.00 1.00 O +ATOM 666 C3' A A 21 -4.999 17.377 9.418 1.00 1.00 C +ATOM 667 O3' A A 21 -6.427 17.478 9.390 1.00 1.00 O +ATOM 668 C2' A A 21 -4.395 18.462 8.537 1.00 1.00 C +ATOM 669 O2' A A 21 -5.304 19.552 8.355 1.00 1.00 O +ATOM 670 C1' A A 21 -3.156 18.896 9.306 1.00 1.00 C +ATOM 671 N9 A A 21 -1.916 18.222 8.876 1.00 1.00 N +ATOM 672 C8 A A 21 -1.290 17.147 9.452 1.00 1.00 C +ATOM 673 N7 A A 21 -0.210 16.768 8.824 1.00 1.00 N +ATOM 674 C5 A A 21 -0.117 17.655 7.756 1.00 1.00 C +ATOM 675 C6 A A 21 0.811 17.789 6.709 1.00 1.00 C +ATOM 676 N6 A A 21 1.867 16.989 6.563 1.00 1.00 N +ATOM 677 N1 A A 21 0.603 18.778 5.825 1.00 1.00 N +ATOM 678 C2 A A 21 -0.452 19.571 5.976 1.00 1.00 C +ATOM 679 N3 A A 21 -1.390 19.546 6.910 1.00 1.00 N +ATOM 680 C4 A A 21 -1.152 18.545 7.782 1.00 1.00 C +ATOM 681 H5' A A 21 -3.658 16.787 12.575 1.00 1.00 H +ATOM 682 H5'' A A 21 -4.986 15.873 11.830 1.00 1.00 H +ATOM 683 H4' A A 21 -5.275 18.235 11.360 1.00 1.00 H +ATOM 684 H3' A A 21 -4.666 16.388 9.103 1.00 1.00 H +ATOM 685 H2' A A 21 -4.104 18.040 7.573 1.00 1.00 H +ATOM 686 HO2' A A 21 -5.714 19.440 7.494 1.00 1.00 H +ATOM 687 H1' A A 21 -3.030 19.974 9.205 1.00 1.00 H +ATOM 688 H8 A A 21 -1.659 16.655 10.352 1.00 1.00 H +ATOM 689 H61 A A 21 2.503 17.129 5.792 1.00 1.00 H +ATOM 690 H62 A A 21 2.031 16.243 7.224 1.00 1.00 H +ATOM 691 H2 A A 21 -0.561 20.351 5.223 1.00 1.00 H +ATOM 692 P A A 22 -7.289 16.580 8.368 1.00 1.00 P +ATOM 693 OP1 A A 22 -8.635 16.380 8.952 1.00 1.00 O +ATOM 694 OP2 A A 22 -6.472 15.410 7.976 1.00 1.00 O +ATOM 695 O5' A A 22 -7.436 17.546 7.090 1.00 1.00 O +ATOM 696 C5' A A 22 -7.064 17.083 5.789 1.00 1.00 C +ATOM 697 C4' A A 22 -6.203 18.107 5.057 1.00 1.00 C +ATOM 698 O4' A A 22 -4.976 18.298 5.769 1.00 1.00 O +ATOM 699 C3' A A 22 -5.846 17.704 3.631 1.00 1.00 C +ATOM 700 O3' A A 22 -6.727 18.358 2.710 1.00 1.00 O +ATOM 701 C2' A A 22 -4.427 18.223 3.446 1.00 1.00 C +ATOM 702 O2' A A 22 -4.420 19.536 2.875 1.00 1.00 O +ATOM 703 C1' A A 22 -3.869 18.229 4.863 1.00 1.00 C +ATOM 704 N9 A A 22 -3.092 17.024 5.200 1.00 1.00 N +ATOM 705 C8 A A 22 -3.412 16.011 6.066 1.00 1.00 C +ATOM 706 N7 A A 22 -2.500 15.080 6.150 1.00 1.00 N +ATOM 707 C5 A A 22 -1.506 15.509 5.276 1.00 1.00 C +ATOM 708 C6 A A 22 -0.267 14.961 4.908 1.00 1.00 C +ATOM 709 N6 A A 22 0.200 13.813 5.400 1.00 1.00 N +ATOM 710 N1 A A 22 0.468 15.646 4.014 1.00 1.00 N +ATOM 711 C2 A A 22 -0.001 16.788 3.529 1.00 1.00 C +ATOM 712 N3 A A 22 -1.145 17.402 3.795 1.00 1.00 N +ATOM 713 C4 A A 22 -1.860 16.692 4.692 1.00 1.00 C +ATOM 714 H5' A A 22 -7.967 16.893 5.208 1.00 1.00 H +ATOM 715 H5'' A A 22 -6.504 16.152 5.890 1.00 1.00 H +ATOM 716 H4' A A 22 -6.737 19.057 5.029 1.00 1.00 H +ATOM 717 H3' A A 22 -5.883 16.620 3.513 1.00 1.00 H +ATOM 718 H2' A A 22 -3.857 17.528 2.824 1.00 1.00 H +ATOM 719 HO2' A A 22 -5.308 19.890 2.959 1.00 1.00 H +ATOM 720 H1' A A 22 -3.240 19.107 5.001 1.00 1.00 H +ATOM 721 H8 A A 22 -4.343 15.985 6.634 1.00 1.00 H +ATOM 722 H61 A A 22 1.098 13.463 5.101 1.00 1.00 H +ATOM 723 H62 A A 22 -0.346 13.291 6.071 1.00 1.00 H +ATOM 724 H2 A A 22 0.645 17.291 2.809 1.00 1.00 H +ATOM 725 P A A 23 -7.458 17.523 1.540 1.00 1.00 P +ATOM 726 OP1 A A 23 -8.376 18.437 0.827 1.00 1.00 O +ATOM 727 OP2 A A 23 -7.976 16.266 2.125 1.00 1.00 O +ATOM 728 O5' A A 23 -6.245 17.153 0.546 1.00 1.00 O +ATOM 729 C5' A A 23 -5.842 18.066 -0.481 1.00 1.00 C +ATOM 730 C4' A A 23 -4.435 17.756 -0.985 1.00 1.00 C +ATOM 731 O4' A A 23 -3.547 17.637 0.128 1.00 1.00 O +ATOM 732 C3' A A 23 -4.332 16.466 -1.789 1.00 1.00 C +ATOM 733 O3' A A 23 -4.389 16.766 -3.188 1.00 1.00 O +ATOM 734 C2' A A 23 -2.955 15.928 -1.436 1.00 1.00 C +ATOM 735 O2' A A 23 -1.965 16.377 -2.367 1.00 1.00 O +ATOM 736 C1' A A 23 -2.704 16.490 -0.042 1.00 1.00 C +ATOM 737 N9 A A 23 -3.015 15.546 1.048 1.00 1.00 N +ATOM 738 C8 A A 23 -4.225 15.263 1.629 1.00 1.00 C +ATOM 739 N7 A A 23 -4.164 14.351 2.560 1.00 1.00 N +ATOM 740 C5 A A 23 -2.816 14.006 2.600 1.00 1.00 C +ATOM 741 C6 A A 23 -2.091 13.089 3.380 1.00 1.00 C +ATOM 742 N6 A A 23 -2.652 12.315 4.309 1.00 1.00 N +ATOM 743 N1 A A 23 -0.769 13.003 3.160 1.00 1.00 N +ATOM 744 C2 A A 23 -0.215 13.773 2.232 1.00 1.00 C +ATOM 745 N3 A A 23 -0.785 14.667 1.439 1.00 1.00 N +ATOM 746 C4 A A 23 -2.110 14.731 1.683 1.00 1.00 C +ATOM 747 H5' A A 23 -5.866 19.081 -0.086 1.00 1.00 H +ATOM 748 H5'' A A 23 -6.541 17.992 -1.315 1.00 1.00 H +ATOM 749 H4' A A 23 -4.097 18.583 -1.605 1.00 1.00 H +ATOM 750 H3' A A 23 -5.112 15.761 -1.500 1.00 1.00 H +ATOM 751 H2' A A 23 -2.979 14.836 -1.396 1.00 1.00 H +ATOM 752 HO2' A A 23 -1.769 17.293 -2.158 1.00 1.00 H +ATOM 753 H1' A A 23 -1.661 16.796 0.038 1.00 1.00 H +ATOM 754 H8 A A 23 -5.154 15.755 1.338 1.00 1.00 H +ATOM 755 H61 A A 23 -2.081 11.671 4.840 1.00 1.00 H +ATOM 756 H62 A A 23 -3.649 12.369 4.483 1.00 1.00 H +ATOM 757 H2 A A 23 0.861 13.653 2.106 1.00 1.00 H +ATOM 758 P C A 24 -5.250 15.846 -4.193 1.00 1.00 P +ATOM 759 OP1 C A 24 -5.147 16.424 -5.551 1.00 1.00 O +ATOM 760 OP2 C A 24 -6.581 15.619 -3.587 1.00 1.00 O +ATOM 761 O5' C A 24 -4.441 14.452 -4.177 1.00 1.00 O +ATOM 762 C5' C A 24 -3.062 14.410 -4.549 1.00 1.00 C +ATOM 763 C4' C A 24 -2.350 13.209 -3.929 1.00 1.00 C +ATOM 764 O4' C A 24 -2.427 13.291 -2.504 1.00 1.00 O +ATOM 765 C3' C A 24 -2.934 11.860 -4.325 1.00 1.00 C +ATOM 766 O3' C A 24 -2.228 11.336 -5.452 1.00 1.00 O +ATOM 767 C2' C A 24 -2.669 10.990 -3.111 1.00 1.00 C +ATOM 768 O2' C A 24 -1.405 10.325 -3.208 1.00 1.00 O +ATOM 769 C1' C A 24 -2.686 11.988 -1.962 1.00 1.00 C +ATOM 770 N1 C A 24 -3.980 12.048 -1.256 1.00 1.00 N +ATOM 771 C2 C A 24 -4.177 11.161 -0.209 1.00 1.00 C +ATOM 772 O2 C A 24 -3.291 10.366 0.098 1.00 1.00 O +ATOM 773 N3 C A 24 -5.364 11.202 0.457 1.00 1.00 N +ATOM 774 C4 C A 24 -6.319 12.076 0.107 1.00 1.00 C +ATOM 775 N4 C A 24 -7.471 12.089 0.780 1.00 1.00 N +ATOM 776 C5 C A 24 -6.119 12.992 -0.972 1.00 1.00 C +ATOM 777 C6 C A 24 -4.941 12.944 -1.623 1.00 1.00 C +ATOM 778 H5' C A 24 -2.574 15.326 -4.214 1.00 1.00 H +ATOM 779 H5'' C A 24 -2.988 14.345 -5.634 1.00 1.00 H +ATOM 780 H4' C A 24 -1.301 13.237 -4.218 1.00 1.00 H +ATOM 781 H3' C A 24 -4.003 11.939 -4.524 1.00 1.00 H +ATOM 782 H2' C A 24 -3.477 10.269 -2.985 1.00 1.00 H +ATOM 783 HO2' C A 24 -1.050 10.256 -2.319 1.00 1.00 H +ATOM 784 H1' C A 24 -1.901 11.732 -1.252 1.00 1.00 H +ATOM 785 H41 C A 24 -7.618 11.448 1.542 1.00 1.00 H +ATOM 786 H42 C A 24 -8.196 12.744 0.525 1.00 1.00 H +ATOM 787 H5 C A 24 -6.894 13.703 -1.259 1.00 1.00 H +ATOM 788 H6 C A 24 -4.753 13.628 -2.452 1.00 1.00 H +ATOM 789 P U A 25 -2.896 10.198 -6.376 1.00 1.00 P +ATOM 790 OP1 U A 25 -1.954 9.882 -7.473 1.00 1.00 O +ATOM 791 OP2 U A 25 -4.283 10.610 -6.689 1.00 1.00 O +ATOM 792 O5' U A 25 -2.958 8.929 -5.386 1.00 1.00 O +ATOM 793 C5' U A 25 -1.758 8.334 -4.883 1.00 1.00 C +ATOM 794 C4' U A 25 -2.057 7.275 -3.825 1.00 1.00 C +ATOM 795 O4' U A 25 -2.784 7.853 -2.743 1.00 1.00 O +ATOM 796 C3' U A 25 -2.892 6.108 -4.324 1.00 1.00 C +ATOM 797 O3' U A 25 -2.036 5.085 -4.849 1.00 1.00 O +ATOM 798 C2' U A 25 -3.591 5.615 -3.069 1.00 1.00 C +ATOM 799 O2' U A 25 -2.842 4.576 -2.431 1.00 1.00 O +ATOM 800 C1' U A 25 -3.676 6.869 -2.193 1.00 1.00 C +ATOM 801 N1 U A 25 -5.025 7.476 -2.144 1.00 1.00 N +ATOM 802 C2 U A 25 -5.861 7.108 -1.106 1.00 1.00 C +ATOM 803 O2 U A 25 -5.518 6.301 -0.245 1.00 1.00 O +ATOM 804 N3 U A 25 -7.111 7.700 -1.093 1.00 1.00 N +ATOM 805 C4 U A 25 -7.591 8.617 -2.013 1.00 1.00 C +ATOM 806 O4 U A 25 -8.723 9.081 -1.905 1.00 1.00 O +ATOM 807 C5 U A 25 -6.651 8.943 -3.063 1.00 1.00 C +ATOM 808 C6 U A 25 -5.421 8.376 -3.096 1.00 1.00 C +ATOM 809 H5' U A 25 -1.133 9.112 -4.443 1.00 1.00 H +ATOM 810 H5'' U A 25 -1.219 7.870 -5.709 1.00 1.00 H +ATOM 811 H4' U A 25 -1.115 6.892 -3.438 1.00 1.00 H +ATOM 812 H3' U A 25 -3.618 6.440 -5.069 1.00 1.00 H +ATOM 813 H2' U A 25 -4.594 5.269 -3.316 1.00 1.00 H +ATOM 814 HO2' U A 25 -2.538 4.919 -1.588 1.00 1.00 H +ATOM 815 H1' U A 25 -3.353 6.619 -1.181 1.00 1.00 H +ATOM 816 H3 U A 25 -7.733 7.441 -0.340 1.00 1.00 H +ATOM 817 H5 U A 25 -6.935 9.655 -3.837 1.00 1.00 H +ATOM 818 H6 U A 25 -4.732 8.638 -3.900 1.00 1.00 H +ATOM 819 P U A 26 -2.615 3.960 -5.849 1.00 1.00 P +ATOM 820 OP1 U A 26 -1.468 3.265 -6.475 1.00 1.00 O +ATOM 821 OP2 U A 26 -3.651 4.588 -6.699 1.00 1.00 O +ATOM 822 O5' U A 26 -3.343 2.927 -4.849 1.00 1.00 O +ATOM 823 C5' U A 26 -2.582 2.184 -3.891 1.00 1.00 C +ATOM 824 C4' U A 26 -3.462 1.658 -2.757 1.00 1.00 C +ATOM 825 O4' U A 26 -4.206 2.729 -2.181 1.00 1.00 O +ATOM 826 C3' U A 26 -4.487 0.617 -3.175 1.00 1.00 C +ATOM 827 O3' U A 26 -3.908 -0.699 -3.130 1.00 1.00 O +ATOM 828 C2' U A 26 -5.566 0.761 -2.109 1.00 1.00 C +ATOM 829 O2' U A 26 -5.340 -0.119 -1.009 1.00 1.00 O +ATOM 830 C1' U A 26 -5.451 2.219 -1.674 1.00 1.00 C +ATOM 831 N1 U A 26 -6.535 3.075 -2.201 1.00 1.00 N +ATOM 832 C2 U A 26 -7.610 3.345 -1.375 1.00 1.00 C +ATOM 833 O2 U A 26 -7.687 2.895 -0.235 1.00 1.00 O +ATOM 834 N3 U A 26 -8.599 4.150 -1.910 1.00 1.00 N +ATOM 835 C4 U A 26 -8.607 4.701 -3.181 1.00 1.00 C +ATOM 836 O4 U A 26 -9.542 5.407 -3.552 1.00 1.00 O +ATOM 837 C5 U A 26 -7.445 4.366 -3.974 1.00 1.00 C +ATOM 838 C6 U A 26 -6.463 3.580 -3.471 1.00 1.00 C +ATOM 839 H5' U A 26 -1.811 2.831 -3.472 1.00 1.00 H +ATOM 840 H5'' U A 26 -2.104 1.342 -4.392 1.00 1.00 H +ATOM 841 H4' U A 26 -2.823 1.235 -1.984 1.00 1.00 H +ATOM 842 H3' U A 26 -4.887 0.843 -4.166 1.00 1.00 H +ATOM 843 H2' U A 26 -6.546 0.587 -2.550 1.00 1.00 H +ATOM 844 HO2' U A 26 -4.789 0.347 -0.376 1.00 1.00 H +ATOM 845 H1' U A 26 -5.442 2.270 -0.585 1.00 1.00 H +ATOM 846 H3 U A 26 -9.392 4.356 -1.318 1.00 1.00 H +ATOM 847 H5 U A 26 -7.360 4.749 -4.990 1.00 1.00 H +ATOM 848 H6 U A 26 -5.597 3.344 -4.091 1.00 1.00 H +ATOM 849 P G A 27 -4.596 -1.939 -3.908 1.00 1.00 P +ATOM 850 OP1 G A 27 -3.685 -3.102 -3.823 1.00 1.00 O +ATOM 851 OP2 G A 27 -5.062 -1.459 -5.228 1.00 1.00 O +ATOM 852 O5' G A 27 -5.887 -2.241 -2.994 1.00 1.00 O +ATOM 853 C5' G A 27 -5.715 -2.493 -1.599 1.00 1.00 C +ATOM 854 C4' G A 27 -6.991 -2.215 -0.816 1.00 1.00 C +ATOM 855 O4' G A 27 -7.510 -0.941 -1.196 1.00 1.00 O +ATOM 856 C3' G A 27 -8.119 -3.206 -1.046 1.00 1.00 C +ATOM 857 O3' G A 27 -8.021 -4.268 -0.085 1.00 1.00 O +ATOM 858 C2' G A 27 -9.367 -2.385 -0.759 1.00 1.00 C +ATOM 859 O2' G A 27 -9.837 -2.597 0.574 1.00 1.00 O +ATOM 860 C1' G A 27 -8.922 -0.939 -0.965 1.00 1.00 C +ATOM 861 N9 G A 27 -9.617 -0.248 -2.069 1.00 1.00 N +ATOM 862 C8 G A 27 -9.202 0.021 -3.347 1.00 1.00 C +ATOM 863 N7 G A 27 -10.069 0.693 -4.054 1.00 1.00 N +ATOM 864 C5 G A 27 -11.137 0.884 -3.180 1.00 1.00 C +ATOM 865 C6 G A 27 -12.376 1.551 -3.384 1.00 1.00 C +ATOM 866 O6 G A 27 -12.779 2.121 -4.396 1.00 1.00 O +ATOM 867 N1 G A 27 -13.170 1.510 -2.246 1.00 1.00 N +ATOM 868 C2 G A 27 -12.819 0.903 -1.059 1.00 1.00 C +ATOM 869 N2 G A 27 -13.718 0.963 -0.078 1.00 1.00 N +ATOM 870 N3 G A 27 -11.655 0.279 -0.864 1.00 1.00 N +ATOM 871 C4 G A 27 -10.868 0.309 -1.964 1.00 1.00 C +ATOM 872 H5' G A 27 -4.919 -1.853 -1.219 1.00 1.00 H +ATOM 873 H5'' G A 27 -5.428 -3.536 -1.458 1.00 1.00 H +ATOM 874 H4' G A 27 -6.754 -2.184 0.247 1.00 1.00 H +ATOM 875 H3' G A 27 -8.117 -3.583 -2.069 1.00 1.00 H +ATOM 876 H2' G A 27 -10.146 -2.636 -1.481 1.00 1.00 H +ATOM 877 HO2' G A 27 -9.074 -2.567 1.154 1.00 1.00 H +ATOM 878 H1' G A 27 -9.112 -0.381 -0.049 1.00 1.00 H +ATOM 879 H8 G A 27 -8.239 -0.303 -3.742 1.00 1.00 H +ATOM 880 H1 G A 27 -14.069 1.966 -2.314 1.00 1.00 H +ATOM 881 H21 G A 27 -14.604 1.434 -0.226 1.00 1.00 H +ATOM 882 H22 G A 27 -13.517 0.536 0.816 1.00 1.00 H +ATOM 883 P G A 28 -8.959 -5.574 -0.193 1.00 1.00 P +ATOM 884 OP1 G A 28 -8.299 -6.672 0.549 1.00 1.00 O +ATOM 885 OP2 G A 28 -9.328 -5.764 -1.614 1.00 1.00 O +ATOM 886 O5' G A 28 -10.287 -5.143 0.620 1.00 1.00 O +ATOM 887 C5' G A 28 -10.296 -5.075 2.054 1.00 1.00 C +ATOM 888 C4' G A 28 -11.723 -5.148 2.609 1.00 1.00 C +ATOM 889 O4' G A 28 -12.305 -3.840 2.671 1.00 1.00 O +ATOM 890 C3' G A 28 -12.653 -6.020 1.777 1.00 1.00 C +ATOM 891 O3' G A 28 -12.725 -7.328 2.352 1.00 1.00 O +ATOM 892 C2' G A 28 -14.000 -5.324 1.885 1.00 1.00 C +ATOM 893 O2' G A 28 -14.763 -5.814 2.994 1.00 1.00 O +ATOM 894 C1' G A 28 -13.611 -3.866 2.076 1.00 1.00 C +ATOM 895 N9 G A 28 -13.517 -3.110 0.825 1.00 1.00 N +ATOM 896 C8 G A 28 -12.388 -2.611 0.229 1.00 1.00 C +ATOM 897 N7 G A 28 -12.612 -2.001 -0.901 1.00 1.00 N +ATOM 898 C5 G A 28 -13.989 -2.102 -1.070 1.00 1.00 C +ATOM 899 C6 G A 28 -14.814 -1.621 -2.124 1.00 1.00 C +ATOM 900 O6 G A 28 -14.480 -1.005 -3.135 1.00 1.00 O +ATOM 901 N1 G A 28 -16.148 -1.933 -1.909 1.00 1.00 N +ATOM 902 C2 G A 28 -16.634 -2.622 -0.817 1.00 1.00 C +ATOM 903 N2 G A 28 -17.949 -2.826 -0.790 1.00 1.00 N +ATOM 904 N3 G A 28 -15.861 -3.074 0.176 1.00 1.00 N +ATOM 905 C4 G A 28 -14.553 -2.779 -0.018 1.00 1.00 C +ATOM 906 H5' G A 28 -9.835 -4.138 2.372 1.00 1.00 H +ATOM 907 H5'' G A 28 -9.718 -5.910 2.453 1.00 1.00 H +ATOM 908 H4' G A 28 -11.682 -5.552 3.620 1.00 1.00 H +ATOM 909 H3' G A 28 -12.322 -6.063 0.737 1.00 1.00 H +ATOM 910 H2' G A 28 -14.556 -5.438 0.952 1.00 1.00 H +ATOM 911 HO2' G A 28 -14.234 -6.485 3.431 1.00 1.00 H +ATOM 912 H1' G A 28 -14.326 -3.381 2.738 1.00 1.00 H +ATOM 913 H8 G A 28 -11.394 -2.710 0.663 1.00 1.00 H +ATOM 914 H1 G A 28 -16.797 -1.624 -2.617 1.00 1.00 H +ATOM 915 H21 G A 28 -18.530 -2.482 -1.543 1.00 1.00 H +ATOM 916 H22 G A 28 -18.367 -3.325 -0.017 1.00 1.00 H +ATOM 917 P U A 29 -12.811 -8.629 1.407 1.00 1.00 P +ATOM 918 OP1 U A 29 -12.650 -9.829 2.259 1.00 1.00 O +ATOM 919 OP2 U A 29 -11.916 -8.421 0.248 1.00 1.00 O +ATOM 920 O5' U A 29 -14.331 -8.590 0.881 1.00 1.00 O +ATOM 921 C5' U A 29 -15.421 -8.851 1.770 1.00 1.00 C +ATOM 922 C4' U A 29 -16.762 -8.750 1.051 1.00 1.00 C +ATOM 923 O4' U A 29 -17.019 -7.397 0.672 1.00 1.00 O +ATOM 924 C3' U A 29 -16.844 -9.579 -0.221 1.00 1.00 C +ATOM 925 O3' U A 29 -17.329 -10.894 0.080 1.00 1.00 O +ATOM 926 C2' U A 29 -17.852 -8.819 -1.064 1.00 1.00 C +ATOM 927 O2' U A 29 -19.187 -9.277 -0.832 1.00 1.00 O +ATOM 928 C1' U A 29 -17.667 -7.374 -0.610 1.00 1.00 C +ATOM 929 N1 U A 29 -16.816 -6.575 -1.515 1.00 1.00 N +ATOM 930 C2 U A 29 -17.435 -5.869 -2.529 1.00 1.00 C +ATOM 931 O2 U A 29 -18.650 -5.911 -2.708 1.00 1.00 O +ATOM 932 N3 U A 29 -16.605 -5.109 -3.335 1.00 1.00 N +ATOM 933 C4 U A 29 -15.230 -4.997 -3.214 1.00 1.00 C +ATOM 934 O4 U A 29 -14.589 -4.290 -3.990 1.00 1.00 O +ATOM 935 C5 U A 29 -14.668 -5.768 -2.128 1.00 1.00 C +ATOM 936 C6 U A 29 -15.462 -6.520 -1.326 1.00 1.00 C +ATOM 937 H5' U A 29 -15.397 -8.127 2.586 1.00 1.00 H +ATOM 938 H5'' U A 29 -15.311 -9.855 2.180 1.00 1.00 H +ATOM 939 H4' U A 29 -17.550 -9.073 1.730 1.00 1.00 H +ATOM 940 H3' U A 29 -15.874 -9.619 -0.720 1.00 1.00 H +ATOM 941 H2' U A 29 -17.593 -8.904 -2.115 1.00 1.00 H +ATOM 942 HO2' U A 29 -19.779 -8.549 -1.037 1.00 1.00 H +ATOM 943 H1' U A 29 -18.643 -6.897 -0.513 1.00 1.00 H +ATOM 944 H3 U A 29 -17.043 -4.587 -4.080 1.00 1.00 H +ATOM 945 H5 U A 29 -13.593 -5.746 -1.952 1.00 1.00 H +ATOM 946 H6 U A 29 -15.012 -7.092 -0.514 1.00 1.00 H +ATOM 947 P U A 30 -16.941 -12.146 -0.862 1.00 1.00 P +ATOM 948 OP1 U A 30 -17.385 -13.388 -0.192 1.00 1.00 O +ATOM 949 OP2 U A 30 -15.526 -11.995 -1.270 1.00 1.00 O +ATOM 950 O5' U A 30 -17.864 -11.921 -2.164 1.00 1.00 O +ATOM 951 C5' U A 30 -19.250 -12.277 -2.150 1.00 1.00 C +ATOM 952 C4' U A 30 -19.949 -11.867 -3.444 1.00 1.00 C +ATOM 953 O4' U A 30 -19.797 -10.464 -3.654 1.00 1.00 O +ATOM 954 C3' U A 30 -19.410 -12.545 -4.697 1.00 1.00 C +ATOM 955 O3' U A 30 -20.103 -13.777 -4.934 1.00 1.00 O +ATOM 956 C2' U A 30 -19.746 -11.545 -5.789 1.00 1.00 C +ATOM 957 O2' U A 30 -21.047 -11.787 -6.333 1.00 1.00 O +ATOM 958 C1' U A 30 -19.676 -10.204 -5.062 1.00 1.00 C +ATOM 959 N1 U A 30 -18.402 -9.489 -5.271 1.00 1.00 N +ATOM 960 C2 U A 30 -18.362 -8.533 -6.267 1.00 1.00 C +ATOM 961 O2 U A 30 -19.334 -8.290 -6.979 1.00 1.00 O +ATOM 962 N3 U A 30 -17.162 -7.862 -6.418 1.00 1.00 N +ATOM 963 C4 U A 30 -16.015 -8.063 -5.670 1.00 1.00 C +ATOM 964 O4 U A 30 -14.999 -7.406 -5.892 1.00 1.00 O +ATOM 965 C5 U A 30 -16.147 -9.081 -4.652 1.00 1.00 C +ATOM 966 C6 U A 30 -17.313 -9.751 -4.484 1.00 1.00 C +ATOM 967 H5' U A 30 -19.738 -11.782 -1.309 1.00 1.00 H +ATOM 968 H5'' U A 30 -19.338 -13.357 -2.026 1.00 1.00 H +ATOM 969 H4' U A 30 -21.012 -12.086 -3.356 1.00 1.00 H +ATOM 970 H3' U A 30 -18.331 -12.698 -4.625 1.00 1.00 H +ATOM 971 H2' U A 30 -18.989 -11.578 -6.570 1.00 1.00 H +ATOM 972 HO2' U A 30 -21.515 -10.951 -6.337 1.00 1.00 H +ATOM 973 H1' U A 30 -20.504 -9.569 -5.381 1.00 1.00 H +ATOM 974 H3 U A 30 -17.118 -7.160 -7.142 1.00 1.00 H +ATOM 975 H5 U A 30 -15.297 -9.313 -4.010 1.00 1.00 H +ATOM 976 H6 U A 30 -17.385 -10.513 -3.709 1.00 1.00 H +ATOM 977 P C A 31 -19.373 -14.997 -5.698 1.00 1.00 P +ATOM 978 OP1 C A 31 -20.339 -16.113 -5.810 1.00 1.00 O +ATOM 979 OP2 C A 31 -18.057 -15.221 -5.061 1.00 1.00 O +ATOM 980 O5' C A 31 -19.122 -14.407 -7.176 1.00 1.00 O +ATOM 981 C5' C A 31 -20.212 -14.180 -8.072 1.00 1.00 C +ATOM 982 C4' C A 31 -19.774 -13.371 -9.290 1.00 1.00 C +ATOM 983 O4' C A 31 -19.338 -12.081 -8.888 1.00 1.00 O +ATOM 984 C3' C A 31 -18.613 -13.974 -10.057 1.00 1.00 C +ATOM 985 O3' C A 31 -19.101 -14.940 -10.997 1.00 1.00 O +ATOM 986 C2' C A 31 -18.042 -12.758 -10.784 1.00 1.00 C +ATOM 987 O2' C A 31 -18.642 -12.583 -12.072 1.00 1.00 O +ATOM 988 C1' C A 31 -18.381 -11.595 -9.842 1.00 1.00 C +ATOM 989 N1 C A 31 -17.222 -11.096 -9.072 1.00 1.00 N +ATOM 990 C2 C A 31 -16.588 -9.950 -9.526 1.00 1.00 C +ATOM 991 O2 C A 31 -16.985 -9.390 -10.544 1.00 1.00 O +ATOM 992 N3 C A 31 -15.526 -9.476 -8.818 1.00 1.00 N +ATOM 993 C4 C A 31 -15.104 -10.099 -7.709 1.00 1.00 C +ATOM 994 N4 C A 31 -14.062 -9.607 -7.040 1.00 1.00 N +ATOM 995 C5 C A 31 -15.756 -11.282 -7.236 1.00 1.00 C +ATOM 996 C6 C A 31 -16.806 -11.743 -7.944 1.00 1.00 C +ATOM 997 H5' C A 31 -21.002 -13.640 -7.547 1.00 1.00 H +ATOM 998 H5'' C A 31 -20.600 -15.142 -8.408 1.00 1.00 H +ATOM 999 H4' C A 31 -20.621 -13.252 -9.962 1.00 1.00 H +ATOM 1000 H3' C A 31 -17.874 -14.407 -9.380 1.00 1.00 H +ATOM 1001 H2' C A 31 -16.965 -12.849 -10.878 1.00 1.00 H +ATOM 1002 HO2' C A 31 -17.936 -12.635 -12.723 1.00 1.00 H +ATOM 1003 H1' C A 31 -18.820 -10.776 -10.415 1.00 1.00 H +ATOM 1004 H41 C A 31 -13.599 -8.774 -7.372 1.00 1.00 H +ATOM 1005 H42 C A 31 -13.734 -10.068 -6.204 1.00 1.00 H +ATOM 1006 H5 C A 31 -15.416 -11.791 -6.334 1.00 1.00 H +ATOM 1007 H6 C A 31 -17.329 -12.641 -7.612 1.00 1.00 H +ATOM 1008 P U A 32 -18.456 -16.420 -11.069 1.00 1.00 P +ATOM 1009 OP1 U A 32 -19.442 -17.320 -11.707 1.00 1.00 O +ATOM 1010 OP2 U A 32 -17.919 -16.750 -9.729 1.00 1.00 O +ATOM 1011 O5' U A 32 -17.216 -16.235 -12.077 1.00 1.00 O +ATOM 1012 C5' U A 32 -17.411 -15.665 -13.371 1.00 1.00 C +ATOM 1013 C4' U A 32 -16.307 -14.671 -13.719 1.00 1.00 C +ATOM 1014 O4' U A 32 -16.197 -13.676 -12.711 1.00 1.00 O +ATOM 1015 C3' U A 32 -14.925 -15.280 -13.841 1.00 1.00 C +ATOM 1016 O3' U A 32 -14.730 -15.769 -15.173 1.00 1.00 O +ATOM 1017 C2' U A 32 -14.007 -14.096 -13.578 1.00 1.00 C +ATOM 1018 O2' U A 32 -13.556 -13.496 -14.796 1.00 1.00 O +ATOM 1019 C1' U A 32 -14.868 -13.131 -12.762 1.00 1.00 C +ATOM 1020 N1 U A 32 -14.380 -12.914 -11.377 1.00 1.00 N +ATOM 1021 C2 U A 32 -13.592 -11.800 -11.154 1.00 1.00 C +ATOM 1022 O2 U A 32 -13.285 -11.026 -12.058 1.00 1.00 O +ATOM 1023 N3 U A 32 -13.167 -11.608 -9.853 1.00 1.00 N +ATOM 1024 C4 U A 32 -13.457 -12.422 -8.770 1.00 1.00 C +ATOM 1025 O4 U A 32 -13.025 -12.153 -7.651 1.00 1.00 O +ATOM 1026 C5 U A 32 -14.285 -13.563 -9.095 1.00 1.00 C +ATOM 1027 C6 U A 32 -14.713 -13.771 -10.364 1.00 1.00 C +ATOM 1028 H5' U A 32 -18.372 -15.152 -13.392 1.00 1.00 H +ATOM 1029 H5'' U A 32 -17.419 -16.464 -14.116 1.00 1.00 H +ATOM 1030 H4' U A 32 -16.562 -14.179 -14.655 1.00 1.00 H +ATOM 1031 H3' U A 32 -14.775 -16.067 -13.098 1.00 1.00 H +ATOM 1032 H2' U A 32 -13.167 -14.419 -12.974 1.00 1.00 H +ATOM 1033 HO2' U A 32 -13.464 -12.555 -14.630 1.00 1.00 H +ATOM 1034 H1' U A 32 -14.905 -12.174 -13.283 1.00 1.00 H +ATOM 1035 H3 U A 32 -12.591 -10.798 -9.674 1.00 1.00 H +ATOM 1036 H5 U A 32 -14.566 -14.264 -8.310 1.00 1.00 H +ATOM 1037 H6 U A 32 -15.336 -14.639 -10.581 1.00 1.00 H +ATOM 1038 P U A 33 -13.565 -16.833 -15.501 1.00 1.00 P +ATOM 1039 OP1 U A 33 -13.798 -17.364 -16.863 1.00 1.00 O +ATOM 1040 OP2 U A 33 -13.452 -17.764 -14.355 1.00 1.00 O +ATOM 1041 O5' U A 33 -12.240 -15.916 -15.539 1.00 1.00 O +ATOM 1042 C5' U A 33 -11.943 -15.116 -16.688 1.00 1.00 C +ATOM 1043 C4' U A 33 -10.757 -14.187 -16.440 1.00 1.00 C +ATOM 1044 O4' U A 33 -10.978 -13.436 -15.252 1.00 1.00 O +ATOM 1045 C3' U A 33 -9.428 -14.902 -16.256 1.00 1.00 C +ATOM 1046 O3' U A 33 -8.752 -14.996 -17.512 1.00 1.00 O +ATOM 1047 C2' U A 33 -8.644 -13.988 -15.325 1.00 1.00 C +ATOM 1048 O2' U A 33 -7.754 -13.138 -16.058 1.00 1.00 O +ATOM 1049 C1' U A 33 -9.722 -13.176 -14.607 1.00 1.00 C +ATOM 1050 N1 U A 33 -9.876 -13.528 -13.180 1.00 1.00 N +ATOM 1051 C2 U A 33 -9.224 -12.739 -12.251 1.00 1.00 C +ATOM 1052 O2 U A 33 -8.533 -11.777 -12.580 1.00 1.00 O +ATOM 1053 N3 U A 33 -9.396 -13.095 -10.925 1.00 1.00 N +ATOM 1054 C4 U A 33 -10.151 -14.155 -10.455 1.00 1.00 C +ATOM 1055 O4 U A 33 -10.234 -14.380 -9.249 1.00 1.00 O +ATOM 1056 C5 U A 33 -10.796 -14.925 -11.495 1.00 1.00 C +ATOM 1057 C6 U A 33 -10.643 -14.596 -12.800 1.00 1.00 C +ATOM 1058 H5' U A 33 -12.820 -14.515 -16.938 1.00 1.00 H +ATOM 1059 H5'' U A 33 -11.712 -15.772 -17.527 1.00 1.00 H +ATOM 1060 H4' U A 33 -10.672 -13.494 -17.275 1.00 1.00 H +ATOM 1061 H3' U A 33 -9.572 -15.886 -15.807 1.00 1.00 H +ATOM 1062 H2' U A 33 -8.090 -14.587 -14.598 1.00 1.00 H +ATOM 1063 HO2' U A 33 -7.132 -12.766 -15.429 1.00 1.00 H +ATOM 1064 H1' U A 33 -9.490 -12.114 -14.696 1.00 1.00 H +ATOM 1065 H3 U A 33 -8.925 -12.527 -10.235 1.00 1.00 H +ATOM 1066 H5 U A 33 -11.415 -15.781 -11.226 1.00 1.00 H +ATOM 1067 H6 U A 33 -11.142 -15.193 -13.565 1.00 1.00 H +ATOM 1068 P C A 34 -7.444 -15.921 -17.661 1.00 1.00 P +ATOM 1069 OP1 C A 34 -6.961 -15.820 -19.056 1.00 1.00 O +ATOM 1070 OP2 C A 34 -7.747 -17.246 -17.078 1.00 1.00 O +ATOM 1071 O5' C A 34 -6.384 -15.177 -16.704 1.00 1.00 O +ATOM 1072 C5' C A 34 -5.653 -15.913 -15.719 1.00 1.00 C +ATOM 1073 C4' C A 34 -4.808 -14.993 -14.840 1.00 1.00 C +ATOM 1074 O4' C A 34 -5.637 -14.340 -13.882 1.00 1.00 O +ATOM 1075 C3' C A 34 -3.721 -15.713 -14.059 1.00 1.00 C +ATOM 1076 O3' C A 34 -2.500 -15.692 -14.806 1.00 1.00 O +ATOM 1077 C2' C A 34 -3.567 -14.886 -12.793 1.00 1.00 C +ATOM 1078 O2' C A 34 -2.491 -13.949 -12.912 1.00 1.00 O +ATOM 1079 C1' C A 34 -4.912 -14.172 -12.655 1.00 1.00 C +ATOM 1080 N1 C A 34 -5.759 -14.699 -11.570 1.00 1.00 N +ATOM 1081 C2 C A 34 -5.480 -14.278 -10.280 1.00 1.00 C +ATOM 1082 O2 C A 34 -4.554 -13.496 -10.076 1.00 1.00 O +ATOM 1083 N3 C A 34 -6.253 -14.752 -9.266 1.00 1.00 N +ATOM 1084 C4 C A 34 -7.260 -15.602 -9.508 1.00 1.00 C +ATOM 1085 N4 C A 34 -7.999 -16.046 -8.492 1.00 1.00 N +ATOM 1086 C5 C A 34 -7.551 -16.039 -10.839 1.00 1.00 C +ATOM 1087 C6 C A 34 -6.780 -15.565 -11.835 1.00 1.00 C +ATOM 1088 H5' C A 34 -4.998 -16.626 -16.220 1.00 1.00 H +ATOM 1089 H5'' C A 34 -6.357 -16.458 -15.090 1.00 1.00 H +ATOM 1090 H4' C A 34 -4.347 -14.234 -15.468 1.00 1.00 H +ATOM 1091 H3' C A 34 -4.024 -16.734 -13.821 1.00 1.00 H +ATOM 1092 H2' C A 34 -3.409 -15.546 -11.936 1.00 1.00 H +ATOM 1093 HO2' C A 34 -2.779 -13.257 -13.510 1.00 1.00 H +ATOM 1094 H1' C A 34 -4.737 -13.110 -12.485 1.00 1.00 H +ATOM 1095 H41 C A 34 -7.797 -15.740 -7.549 1.00 1.00 H +ATOM 1096 H42 C A 34 -8.760 -16.687 -8.662 1.00 1.00 H +ATOM 1097 H5 C A 34 -8.370 -16.729 -11.040 1.00 1.00 H +ATOM 1098 H6 C A 34 -6.973 -15.874 -12.863 1.00 1.00 H +ATOM 1099 P C A 35 -1.359 -16.793 -14.535 1.00 1.00 P +ATOM 1100 OP1 C A 35 -0.200 -16.483 -15.402 1.00 1.00 O +ATOM 1101 OP2 C A 35 -1.985 -18.133 -14.591 1.00 1.00 O +ATOM 1102 O5' C A 35 -0.940 -16.495 -13.011 1.00 1.00 O +ATOM 1103 C5' C A 35 -0.577 -17.566 -12.136 1.00 1.00 C +ATOM 1104 C4' C A 35 0.174 -17.059 -10.910 1.00 1.00 C +ATOM 1105 O4' C A 35 -0.671 -16.208 -10.141 1.00 1.00 O +ATOM 1106 C3' C A 35 0.654 -18.164 -9.985 1.00 1.00 C +ATOM 1107 O3' C A 35 1.998 -18.518 -10.329 1.00 1.00 O +ATOM 1108 C2' C A 35 0.613 -17.531 -8.604 1.00 1.00 C +ATOM 1109 O2' C A 35 1.889 -16.997 -8.237 1.00 1.00 O +ATOM 1110 C1' C A 35 -0.436 -16.428 -8.744 1.00 1.00 C +ATOM 1111 N1 C A 35 -1.734 -16.757 -8.130 1.00 1.00 N +ATOM 1112 C2 C A 35 -1.866 -16.545 -6.767 1.00 1.00 C +ATOM 1113 O2 C A 35 -0.920 -16.104 -6.119 1.00 1.00 O +ATOM 1114 N3 C A 35 -3.059 -16.840 -6.181 1.00 1.00 N +ATOM 1115 C4 C A 35 -4.080 -17.321 -6.903 1.00 1.00 C +ATOM 1116 N4 C A 35 -5.235 -17.599 -6.298 1.00 1.00 N +ATOM 1117 C5 C A 35 -3.947 -17.542 -8.311 1.00 1.00 C +ATOM 1118 C6 C A 35 -2.762 -17.248 -8.880 1.00 1.00 C +ATOM 1119 H5' C A 35 0.056 -18.267 -12.677 1.00 1.00 H +ATOM 1120 H5'' C A 35 -1.481 -18.079 -11.810 1.00 1.00 H +ATOM 1121 H4' C A 35 1.034 -16.480 -11.241 1.00 1.00 H +ATOM 1122 H3' C A 35 -0.008 -19.030 -10.036 1.00 1.00 H +ATOM 1123 H2' C A 35 0.279 -18.266 -7.869 1.00 1.00 H +ATOM 1124 HO2' C A 35 1.811 -16.040 -8.240 1.00 1.00 H +ATOM 1125 H1' C A 35 -0.053 -15.512 -8.296 1.00 1.00 H +ATOM 1126 H41 C A 35 -5.330 -17.445 -5.300 1.00 1.00 H +ATOM 1127 H42 C A 35 -6.011 -17.963 -6.832 1.00 1.00 H +ATOM 1128 H5 C A 35 -4.776 -17.935 -8.901 1.00 1.00 H +ATOM 1129 H6 C A 35 -2.625 -17.404 -9.950 1.00 1.00 H +ATOM 1130 P U A 36 2.566 -19.986 -9.998 1.00 1.00 P +ATOM 1131 OP1 U A 36 3.846 -20.158 -10.721 1.00 1.00 O +ATOM 1132 OP2 U A 36 1.470 -20.961 -10.194 1.00 1.00 O +ATOM 1133 O5' U A 36 2.882 -19.890 -8.424 1.00 1.00 O +ATOM 1134 C5' U A 36 2.526 -20.958 -7.544 1.00 1.00 C +ATOM 1135 C4' U A 36 2.495 -20.499 -6.090 1.00 1.00 C +ATOM 1136 O4' U A 36 1.331 -19.709 -5.855 1.00 1.00 O +ATOM 1137 C3' U A 36 2.465 -21.638 -5.082 1.00 1.00 C +ATOM 1138 O3' U A 36 3.798 -21.950 -4.666 1.00 1.00 O +ATOM 1139 C2' U A 36 1.684 -21.071 -3.907 1.00 1.00 C +ATOM 1140 O2' U A 36 2.560 -20.611 -2.874 1.00 1.00 O +ATOM 1141 C1' U A 36 0.892 -19.911 -4.507 1.00 1.00 C +ATOM 1142 N1 U A 36 -0.562 -20.134 -4.528 1.00 1.00 N +ATOM 1143 C2 U A 36 -1.186 -20.293 -3.306 1.00 1.00 C +ATOM 1144 O2 U A 36 -0.562 -20.273 -2.247 1.00 1.00 O +ATOM 1145 N3 U A 36 -2.556 -20.477 -3.343 1.00 1.00 N +ATOM 1146 C4 U A 36 -3.345 -20.515 -4.481 1.00 1.00 C +ATOM 1147 O4 U A 36 -4.559 -20.683 -4.395 1.00 1.00 O +ATOM 1148 C5 U A 36 -2.609 -20.341 -5.713 1.00 1.00 C +ATOM 1149 C6 U A 36 -1.266 -20.159 -5.702 1.00 1.00 C +ATOM 1150 H5' U A 36 3.253 -21.763 -7.649 1.00 1.00 H +ATOM 1151 H5'' U A 36 1.539 -21.329 -7.820 1.00 1.00 H +ATOM 1152 H4' U A 36 3.371 -19.884 -5.897 1.00 1.00 H +ATOM 1153 H3' U A 36 1.961 -22.512 -5.498 1.00 1.00 H +ATOM 1154 H2' U A 36 0.996 -21.827 -3.518 1.00 1.00 H +ATOM 1155 HO2' U A 36 3.244 -20.084 -3.292 1.00 1.00 H +ATOM 1156 H1' U A 36 1.099 -19.010 -3.930 1.00 1.00 H +ATOM 1157 H3 U A 36 -3.026 -20.593 -2.456 1.00 1.00 H +ATOM 1158 H5 U A 36 -3.142 -20.355 -6.663 1.00 1.00 H +ATOM 1159 H6 U A 36 -0.737 -20.032 -6.646 1.00 1.00 H +ATOM 1160 P A A 37 4.169 -23.424 -4.131 1.00 1.00 P +ATOM 1161 OP1 A A 37 5.623 -23.467 -3.866 1.00 1.00 O +ATOM 1162 OP2 A A 37 3.554 -24.416 -5.042 1.00 1.00 O +ATOM 1163 O5' A A 37 3.398 -23.494 -2.718 1.00 1.00 O +ATOM 1164 C5' A A 37 3.691 -22.548 -1.685 1.00 1.00 C +ATOM 1165 C4' A A 37 2.845 -22.796 -0.439 1.00 1.00 C +ATOM 1166 O4' A A 37 1.462 -22.609 -0.760 1.00 1.00 O +ATOM 1167 C3' A A 37 2.998 -24.198 0.140 1.00 1.00 C +ATOM 1168 O3' A A 37 2.993 -24.122 1.569 1.00 1.00 O +ATOM 1169 C2' A A 37 1.763 -24.941 -0.339 1.00 1.00 C +ATOM 1170 O2' A A 37 1.302 -25.877 0.643 1.00 1.00 O +ATOM 1171 C1' A A 37 0.744 -23.833 -0.569 1.00 1.00 C +ATOM 1172 N9 A A 37 -0.109 -24.041 -1.754 1.00 1.00 N +ATOM 1173 C8 A A 37 0.254 -24.422 -3.020 1.00 1.00 C +ATOM 1174 N7 A A 37 -0.748 -24.524 -3.849 1.00 1.00 N +ATOM 1175 C5 A A 37 -1.854 -24.186 -3.077 1.00 1.00 C +ATOM 1176 C6 A A 37 -3.226 -24.100 -3.369 1.00 1.00 C +ATOM 1177 N6 A A 37 -3.732 -24.361 -4.574 1.00 1.00 N +ATOM 1178 N1 A A 37 -4.047 -23.736 -2.371 1.00 1.00 N +ATOM 1179 C2 A A 37 -3.536 -23.478 -1.172 1.00 1.00 C +ATOM 1180 N3 A A 37 -2.274 -23.523 -0.775 1.00 1.00 N +ATOM 1181 C4 A A 37 -1.474 -23.891 -1.798 1.00 1.00 C +ATOM 1182 H5' A A 37 3.493 -21.543 -2.056 1.00 1.00 H +ATOM 1183 H5'' A A 37 4.745 -22.627 -1.419 1.00 1.00 H +ATOM 1184 H4' A A 37 3.122 -22.069 0.324 1.00 1.00 H +ATOM 1185 H3' A A 37 3.908 -24.674 -0.229 1.00 1.00 H +ATOM 1186 H2' A A 37 1.978 -25.449 -1.282 1.00 1.00 H +ATOM 1187 HO2' A A 37 0.857 -26.586 0.174 1.00 1.00 H +ATOM 1188 H1' A A 37 0.111 -23.742 0.312 1.00 1.00 H +ATOM 1189 H8 A A 37 1.287 -24.621 -3.308 1.00 1.00 H +ATOM 1190 H61 A A 37 -4.727 -24.285 -4.732 1.00 1.00 H +ATOM 1191 H62 A A 37 -3.122 -24.636 -5.331 1.00 1.00 H +ATOM 1192 H2 A A 37 -4.258 -23.188 -0.408 1.00 1.00 H +ATOM 1193 P A A 38 3.736 -25.247 2.451 1.00 1.00 P +ATOM 1194 OP1 A A 38 5.132 -25.358 1.975 1.00 1.00 O +ATOM 1195 OP2 A A 38 2.872 -26.448 2.490 1.00 1.00 O +ATOM 1196 O5' A A 38 3.754 -24.592 3.922 1.00 1.00 O +ATOM 1197 C5' A A 38 2.928 -25.124 4.961 1.00 1.00 C +ATOM 1198 C4' A A 38 2.515 -24.045 5.964 1.00 1.00 C +ATOM 1199 O4' A A 38 2.236 -22.827 5.268 1.00 1.00 O +ATOM 1200 C3' A A 38 1.281 -24.404 6.787 1.00 1.00 C +ATOM 1201 O3' A A 38 1.687 -24.836 8.090 1.00 1.00 O +ATOM 1202 C2' A A 38 0.513 -23.096 6.895 1.00 1.00 C +ATOM 1203 O2' A A 38 0.844 -22.394 8.098 1.00 1.00 O +ATOM 1204 C1' A A 38 0.957 -22.322 5.662 1.00 1.00 C +ATOM 1205 N9 A A 38 0.051 -22.464 4.507 1.00 1.00 N +ATOM 1206 C8 A A 38 0.256 -23.143 3.335 1.00 1.00 C +ATOM 1207 N7 A A 38 -0.749 -23.080 2.505 1.00 1.00 N +ATOM 1208 C5 A A 38 -1.686 -22.300 3.177 1.00 1.00 C +ATOM 1209 C6 A A 38 -2.974 -21.859 2.834 1.00 1.00 C +ATOM 1210 N6 A A 38 -3.565 -22.156 1.676 1.00 1.00 N +ATOM 1211 N1 A A 38 -3.626 -21.102 3.733 1.00 1.00 N +ATOM 1212 C2 A A 38 -3.034 -20.810 4.884 1.00 1.00 C +ATOM 1213 N3 A A 38 -1.834 -21.162 5.321 1.00 1.00 N +ATOM 1214 C4 A A 38 -1.206 -21.920 4.397 1.00 1.00 C +ATOM 1215 H5' A A 38 3.478 -25.904 5.487 1.00 1.00 H +ATOM 1216 H5'' A A 38 2.034 -25.557 4.514 1.00 1.00 H +ATOM 1217 H4' A A 38 3.347 -23.867 6.644 1.00 1.00 H +ATOM 1218 H3' A A 38 0.682 -25.166 6.287 1.00 1.00 H +ATOM 1219 H2' A A 38 -0.562 -23.287 6.845 1.00 1.00 H +ATOM 1220 HO2' A A 38 0.634 -21.468 7.956 1.00 1.00 H +ATOM 1221 H1' A A 38 1.048 -21.267 5.916 1.00 1.00 H +ATOM 1222 H8 A A 38 1.175 -23.689 3.116 1.00 1.00 H +ATOM 1223 H61 A A 38 -4.494 -21.812 1.480 1.00 1.00 H +ATOM 1224 H62 A A 38 -3.083 -22.725 0.994 1.00 1.00 H +ATOM 1225 H2 A A 38 -3.618 -20.192 5.568 1.00 1.00 H +ATOM 1226 P G A 39 0.926 -26.049 8.828 1.00 1.00 P +ATOM 1227 OP1 G A 39 1.643 -26.345 10.088 1.00 1.00 O +ATOM 1228 OP2 G A 39 0.701 -27.126 7.838 1.00 1.00 O +ATOM 1229 O5' G A 39 -0.501 -25.404 9.203 1.00 1.00 O +ATOM 1230 C5' G A 39 -0.586 -24.318 10.129 1.00 1.00 C +ATOM 1231 C4' G A 39 -2.012 -23.787 10.244 1.00 1.00 C +ATOM 1232 O4' G A 39 -2.386 -23.172 9.008 1.00 1.00 O +ATOM 1233 C3' G A 39 -3.050 -24.864 10.552 1.00 1.00 C +ATOM 1234 O3' G A 39 -3.382 -24.831 11.944 1.00 1.00 O +ATOM 1235 C2' G A 39 -4.260 -24.443 9.735 1.00 1.00 C +ATOM 1236 O2' G A 39 -5.133 -23.593 10.488 1.00 1.00 O +ATOM 1237 C1' G A 39 -3.638 -23.703 8.565 1.00 1.00 C +ATOM 1238 N9 G A 39 -3.375 -24.560 7.396 1.00 1.00 N +ATOM 1239 C8 G A 39 -2.237 -25.251 7.072 1.00 1.00 C +ATOM 1240 N7 G A 39 -2.320 -25.911 5.950 1.00 1.00 N +ATOM 1241 C5 G A 39 -3.607 -25.638 5.496 1.00 1.00 C +ATOM 1242 C6 G A 39 -4.271 -26.081 4.319 1.00 1.00 C +ATOM 1243 O6 G A 39 -3.844 -26.818 3.433 1.00 1.00 O +ATOM 1244 N1 G A 39 -5.561 -25.575 4.241 1.00 1.00 N +ATOM 1245 C2 G A 39 -6.143 -24.744 5.176 1.00 1.00 C +ATOM 1246 N2 G A 39 -7.394 -24.359 4.925 1.00 1.00 N +ATOM 1247 N3 G A 39 -5.521 -24.326 6.283 1.00 1.00 N +ATOM 1248 C4 G A 39 -4.261 -24.811 6.376 1.00 1.00 C +ATOM 1249 H5' G A 39 0.068 -23.512 9.792 1.00 1.00 H +ATOM 1250 H5'' G A 39 -0.252 -24.658 11.110 1.00 1.00 H +ATOM 1251 H4' G A 39 -2.045 -23.032 11.028 1.00 1.00 H +ATOM 1252 H3' G A 39 -2.696 -25.851 10.249 1.00 1.00 H +ATOM 1253 H2' G A 39 -4.795 -25.322 9.373 1.00 1.00 H +ATOM 1254 HO2' G A 39 -4.816 -23.588 11.393 1.00 1.00 H +ATOM 1255 H1' G A 39 -4.292 -22.884 8.267 1.00 1.00 H +ATOM 1256 H8 G A 39 -1.342 -25.249 7.694 1.00 1.00 H +ATOM 1257 H1 G A 39 -6.098 -25.847 3.430 1.00 1.00 H +ATOM 1258 H21 G A 39 -7.861 -24.676 4.088 1.00 1.00 H +ATOM 1259 H22 G A 39 -7.874 -23.751 5.572 1.00 1.00 H +ATOM 1260 P U A 40 -3.600 -26.199 12.765 1.00 1.00 P +ATOM 1261 OP1 U A 40 -4.025 -25.849 14.139 1.00 1.00 O +ATOM 1262 OP2 U A 40 -2.413 -27.057 12.555 1.00 1.00 O +ATOM 1263 O5' U A 40 -4.851 -26.879 12.011 1.00 1.00 O +ATOM 1264 C5' U A 40 -6.194 -26.523 12.353 1.00 1.00 C +ATOM 1265 C4' U A 40 -7.205 -27.349 11.564 1.00 1.00 C +ATOM 1266 O4' U A 40 -7.142 -27.006 10.180 1.00 1.00 O +ATOM 1267 C3' U A 40 -6.980 -28.851 11.654 1.00 1.00 C +ATOM 1268 O3' U A 40 -7.733 -29.402 12.745 1.00 1.00 O +ATOM 1269 C2' U A 40 -7.523 -29.365 10.331 1.00 1.00 C +ATOM 1270 O2' U A 40 -8.903 -29.735 10.435 1.00 1.00 O +ATOM 1271 C1' U A 40 -7.325 -28.186 9.382 1.00 1.00 C +ATOM 1272 N1 U A 40 -6.139 -28.321 8.515 1.00 1.00 N +ATOM 1273 C2 U A 40 -6.325 -28.856 7.254 1.00 1.00 C +ATOM 1274 O2 U A 40 -7.427 -29.234 6.859 1.00 1.00 O +ATOM 1275 N3 U A 40 -5.197 -28.943 6.459 1.00 1.00 N +ATOM 1276 C4 U A 40 -3.917 -28.546 6.810 1.00 1.00 C +ATOM 1277 O4 U A 40 -2.984 -28.669 6.019 1.00 1.00 O +ATOM 1278 C5 U A 40 -3.817 -27.999 8.145 1.00 1.00 C +ATOM 1279 C6 U A 40 -4.909 -27.905 8.942 1.00 1.00 C +ATOM 1280 H5' U A 40 -6.348 -25.466 12.131 1.00 1.00 H +ATOM 1281 H5'' U A 40 -6.347 -26.690 13.419 1.00 1.00 H +ATOM 1282 H4' U A 40 -8.206 -27.121 11.928 1.00 1.00 H +ATOM 1283 H3' U A 40 -5.916 -29.078 11.752 1.00 1.00 H +ATOM 1284 H2' U A 40 -6.925 -30.204 9.990 1.00 1.00 H +ATOM 1285 HO2' U A 40 -8.945 -30.696 10.424 1.00 1.00 H +ATOM 1286 H1' U A 40 -8.216 -28.066 8.761 1.00 1.00 H +ATOM 1287 H3 U A 40 -5.318 -29.331 5.534 1.00 1.00 H +ATOM 1288 H5 U A 40 -2.850 -27.659 8.515 1.00 1.00 H +ATOM 1289 H6 U A 40 -4.804 -27.488 9.944 1.00 1.00 H +ATOM 1290 P C A 41 -7.138 -30.627 13.614 1.00 1.00 P +ATOM 1291 OP1 C A 41 -7.867 -30.677 14.901 1.00 1.00 O +ATOM 1292 OP2 C A 41 -5.661 -30.526 13.605 1.00 1.00 O +ATOM 1293 O5' C A 41 -7.557 -31.920 12.748 1.00 1.00 O +ATOM 1294 C5' C A 41 -8.917 -32.364 12.704 1.00 1.00 C +ATOM 1295 C4' C A 41 -9.179 -33.228 11.472 1.00 1.00 C +ATOM 1296 O4' C A 41 -8.727 -32.535 10.316 1.00 1.00 O +ATOM 1297 C3' C A 41 -8.471 -34.575 11.473 1.00 1.00 C +ATOM 1298 O3' C A 41 -9.324 -35.576 12.047 1.00 1.00 O +ATOM 1299 C2' C A 41 -8.262 -34.859 9.992 1.00 1.00 C +ATOM 1300 O2' C A 41 -9.346 -35.614 9.443 1.00 1.00 O +ATOM 1301 C1' C A 41 -8.181 -33.466 9.371 1.00 1.00 C +ATOM 1302 N1 C A 41 -6.799 -33.029 9.071 1.00 1.00 N +ATOM 1303 C2 C A 41 -6.360 -33.148 7.762 1.00 1.00 C +ATOM 1304 O2 C A 41 -7.108 -33.609 6.901 1.00 1.00 O +ATOM 1305 N3 C A 41 -5.094 -32.743 7.466 1.00 1.00 N +ATOM 1306 C4 C A 41 -4.292 -32.244 8.416 1.00 1.00 C +ATOM 1307 N4 C A 41 -3.058 -31.859 8.094 1.00 1.00 N +ATOM 1308 C5 C A 41 -4.741 -32.119 9.769 1.00 1.00 C +ATOM 1309 C6 C A 41 -5.996 -32.522 10.051 1.00 1.00 C +ATOM 1310 H5' C A 41 -9.576 -31.496 12.676 1.00 1.00 H +ATOM 1311 H5'' C A 41 -9.130 -32.946 13.600 1.00 1.00 H +ATOM 1312 H4' C A 41 -10.249 -33.388 11.375 1.00 1.00 H +ATOM 1313 H3' C A 41 -7.516 -34.515 11.997 1.00 1.00 H +ATOM 1314 H2' C A 41 -7.317 -35.381 9.845 1.00 1.00 H +ATOM 1315 HO2' C A 41 -10.099 -35.499 10.028 1.00 1.00 H +ATOM 1316 H1' C A 41 -8.777 -33.440 8.456 1.00 1.00 H +ATOM 1317 H41 C A 41 -2.736 -31.943 7.144 1.00 1.00 H +ATOM 1318 H42 C A 41 -2.447 -31.481 8.805 1.00 1.00 H +ATOM 1319 H5 C A 41 -4.090 -31.714 10.543 1.00 1.00 H +ATOM 1320 H6 C A 41 -6.371 -32.443 11.070 1.00 1.00 H +ATOM 1321 P C A 42 -8.697 -36.899 12.724 1.00 1.00 P +ATOM 1322 OP1 C A 42 -9.802 -37.669 13.340 1.00 1.00 O +ATOM 1323 OP2 C A 42 -7.534 -36.494 13.544 1.00 1.00 O +ATOM 1324 O5' C A 42 -8.152 -37.736 11.458 1.00 1.00 O +ATOM 1325 C5' C A 42 -9.063 -38.372 10.555 1.00 1.00 C +ATOM 1326 C4' C A 42 -8.348 -38.892 9.308 1.00 1.00 C +ATOM 1327 O4' C A 42 -7.645 -37.832 8.672 1.00 1.00 O +ATOM 1328 C3' C A 42 -7.320 -39.977 9.578 1.00 1.00 C +ATOM 1329 O3' C A 42 -7.939 -41.266 9.531 1.00 1.00 O +ATOM 1330 C2' C A 42 -6.344 -39.830 8.421 1.00 1.00 C +ATOM 1331 O2' C A 42 -6.662 -40.724 7.350 1.00 1.00 O +ATOM 1332 C1' C A 42 -6.501 -38.371 7.993 1.00 1.00 C +ATOM 1333 N1 C A 42 -5.341 -37.520 8.333 1.00 1.00 N +ATOM 1334 C2 C A 42 -4.385 -37.322 7.350 1.00 1.00 C +ATOM 1335 O2 C A 42 -4.511 -37.860 6.253 1.00 1.00 O +ATOM 1336 N3 C A 42 -3.316 -36.529 7.639 1.00 1.00 N +ATOM 1337 C4 C A 42 -3.192 -35.954 8.843 1.00 1.00 C +ATOM 1338 N4 C A 42 -2.134 -35.182 9.092 1.00 1.00 N +ATOM 1339 C5 C A 42 -4.177 -36.156 9.860 1.00 1.00 C +ATOM 1340 C6 C A 42 -5.230 -36.942 9.565 1.00 1.00 C +ATOM 1341 H5' C A 42 -9.828 -37.655 10.256 1.00 1.00 H +ATOM 1342 H5'' C A 42 -9.540 -39.209 11.066 1.00 1.00 H +ATOM 1343 H4' C A 42 -9.091 -39.274 8.611 1.00 1.00 H +ATOM 1344 H3' C A 42 -6.819 -39.810 10.533 1.00 1.00 H +ATOM 1345 H2' C A 42 -5.329 -40.001 8.770 1.00 1.00 H +ATOM 1346 HO2' C A 42 -7.616 -40.811 7.322 1.00 1.00 H +ATOM 1347 H1' C A 42 -6.675 -38.333 6.917 1.00 1.00 H +ATOM 1348 H41 C A 42 -1.431 -35.038 8.371 1.00 1.00 H +ATOM 1349 H42 C A 42 -2.028 -34.743 9.996 1.00 1.00 H +ATOM 1350 H5 C A 42 -4.078 -35.690 10.841 1.00 1.00 H +ATOM 1351 H6 C A 42 -5.999 -37.121 10.316 1.00 1.00 H +ATOM 1352 P U A 43 -7.276 -42.517 10.300 1.00 1.00 P +ATOM 1353 OP1 U A 43 -8.034 -43.736 9.936 1.00 1.00 O +ATOM 1354 OP2 U A 43 -7.108 -42.152 11.724 1.00 1.00 O +ATOM 1355 O5' U A 43 -5.813 -42.614 9.627 1.00 1.00 O +ATOM 1356 C5' U A 43 -5.668 -42.960 8.247 1.00 1.00 C +ATOM 1357 C4' U A 43 -4.213 -42.875 7.787 1.00 1.00 C +ATOM 1358 O4' U A 43 -3.759 -41.534 7.851 1.00 1.00 O +ATOM 1359 C3' U A 43 -3.238 -43.696 8.624 1.00 1.00 C +ATOM 1360 O3' U A 43 -3.005 -44.980 8.037 1.00 1.00 O +ATOM 1361 C2' U A 43 -1.957 -42.851 8.640 1.00 1.00 C +ATOM 1362 O2' U A 43 -0.882 -43.527 7.982 1.00 1.00 O +ATOM 1363 C1' U A 43 -2.337 -41.571 7.901 1.00 1.00 C +ATOM 1364 N1 U A 43 -1.863 -40.336 8.565 1.00 1.00 N +ATOM 1365 C2 U A 43 -0.692 -39.769 8.100 1.00 1.00 C +ATOM 1366 O2 U A 43 -0.054 -40.256 7.168 1.00 1.00 O +ATOM 1367 N3 U A 43 -0.275 -38.618 8.744 1.00 1.00 N +ATOM 1368 C4 U A 43 -0.920 -37.995 9.800 1.00 1.00 C +ATOM 1369 O4 U A 43 -0.459 -36.968 10.296 1.00 1.00 O +ATOM 1370 C5 U A 43 -2.135 -38.658 10.220 1.00 1.00 C +ATOM 1371 C6 U A 43 -2.562 -39.785 9.604 1.00 1.00 C +ATOM 1372 H5' U A 43 -6.270 -42.281 7.643 1.00 1.00 H +ATOM 1373 H5'' U A 43 -6.026 -43.978 8.097 1.00 1.00 H +ATOM 1374 H4' U A 43 -4.154 -43.204 6.751 1.00 1.00 H +ATOM 1375 H3' U A 43 -3.624 -43.803 9.641 1.00 1.00 H +ATOM 1376 HO3' U A 43 -3.773 -45.524 8.226 1.00 1.00 H +ATOM 1377 H2' U A 43 -1.684 -42.610 9.669 1.00 1.00 H +ATOM 1378 HO2' U A 43 -0.142 -42.915 7.944 1.00 1.00 H +ATOM 1379 H1' U A 43 -1.945 -41.612 6.884 1.00 1.00 H +ATOM 1380 H3 U A 43 0.579 -38.193 8.414 1.00 1.00 H +ATOM 1381 H5 U A 43 -2.714 -38.244 11.046 1.00 1.00 H +ATOM 1382 H6 U A 43 -3.481 -40.263 9.942 1.00 1.00 H +TER 1383 U A 43 +ATOM 1384 O5' G B 44 -6.284 32.507 13.512 1.00 1.00 O +ATOM 1385 C5' G B 44 -7.603 32.789 13.044 1.00 1.00 C +ATOM 1386 C4' G B 44 -7.684 34.183 12.420 1.00 1.00 C +ATOM 1387 O4' G B 44 -7.720 35.175 13.456 1.00 1.00 O +ATOM 1388 C3' G B 44 -6.510 34.515 11.499 1.00 1.00 C +ATOM 1389 O3' G B 44 -6.927 34.419 10.132 1.00 1.00 O +ATOM 1390 C2' G B 44 -6.179 35.959 11.831 1.00 1.00 C +ATOM 1391 O2' G B 44 -6.887 36.865 10.979 1.00 1.00 O +ATOM 1392 C1' G B 44 -6.632 36.084 13.275 1.00 1.00 C +ATOM 1393 N9 G B 44 -5.594 35.731 14.259 1.00 1.00 N +ATOM 1394 C8 G B 44 -5.572 34.683 15.143 1.00 1.00 C +ATOM 1395 N7 G B 44 -4.500 34.637 15.882 1.00 1.00 N +ATOM 1396 C5 G B 44 -3.754 35.734 15.460 1.00 1.00 C +ATOM 1397 C6 G B 44 -2.485 36.197 15.904 1.00 1.00 C +ATOM 1398 O6 G B 44 -1.759 35.718 16.773 1.00 1.00 O +ATOM 1399 N1 G B 44 -2.090 37.337 15.217 1.00 1.00 N +ATOM 1400 C2 G B 44 -2.821 37.958 14.227 1.00 1.00 C +ATOM 1401 N2 G B 44 -2.273 39.045 13.683 1.00 1.00 N +ATOM 1402 N3 G B 44 -4.014 37.525 13.806 1.00 1.00 N +ATOM 1403 C4 G B 44 -4.416 36.411 14.466 1.00 1.00 C +ATOM 1404 H5' G B 44 -8.299 32.721 13.883 1.00 1.00 H +ATOM 1405 H5'' G B 44 -7.883 32.052 12.294 1.00 1.00 H +ATOM 1406 H4' G B 44 -8.607 34.252 11.846 1.00 1.00 H +ATOM 1407 H3' G B 44 -5.659 33.862 11.702 1.00 1.00 H +ATOM 1408 H2' G B 44 -5.103 36.124 11.764 1.00 1.00 H +ATOM 1409 HO2' G B 44 -7.056 37.662 11.487 1.00 1.00 H +ATOM 1410 H1' G B 44 -6.974 37.101 13.462 1.00 1.00 H +ATOM 1411 H8 G B 44 -6.380 33.956 15.223 1.00 1.00 H +ATOM 1412 H1 G B 44 -1.196 37.726 15.479 1.00 1.00 H +ATOM 1413 H21 G B 44 -1.371 39.370 14.003 1.00 1.00 H +ATOM 1414 H22 G B 44 -2.759 39.544 12.952 1.00 1.00 H +ATOM 1415 HO5' G B 44 -6.025 31.658 13.146 1.00 1.00 H +ATOM 1416 P G B 45 -5.876 34.023 8.976 1.00 1.00 P +ATOM 1417 OP1 G B 45 -6.526 34.249 7.666 1.00 1.00 O +ATOM 1418 OP2 G B 45 -5.311 32.694 9.299 1.00 1.00 O +ATOM 1419 O5' G B 45 -4.712 35.121 9.150 1.00 1.00 O +ATOM 1420 C5' G B 45 -4.932 36.488 8.790 1.00 1.00 C +ATOM 1421 C4' G B 45 -3.652 37.310 8.927 1.00 1.00 C +ATOM 1422 O4' G B 45 -3.283 37.416 10.301 1.00 1.00 O +ATOM 1423 C3' G B 45 -2.458 36.719 8.195 1.00 1.00 C +ATOM 1424 O3' G B 45 -2.388 37.249 6.869 1.00 1.00 O +ATOM 1425 C2' G B 45 -1.271 37.200 9.011 1.00 1.00 C +ATOM 1426 O2' G B 45 -0.759 38.437 8.506 1.00 1.00 O +ATOM 1427 C1' G B 45 -1.852 37.360 10.416 1.00 1.00 C +ATOM 1428 N9 G B 45 -1.529 36.249 11.328 1.00 1.00 N +ATOM 1429 C8 G B 45 -2.280 35.146 11.642 1.00 1.00 C +ATOM 1430 N7 G B 45 -1.710 34.347 12.501 1.00 1.00 N +ATOM 1431 C5 G B 45 -0.493 34.963 12.777 1.00 1.00 C +ATOM 1432 C6 G B 45 0.559 34.557 13.645 1.00 1.00 C +ATOM 1433 O6 G B 45 0.621 33.552 14.352 1.00 1.00 O +ATOM 1434 N1 G B 45 1.609 35.464 13.630 1.00 1.00 N +ATOM 1435 C2 G B 45 1.647 36.619 12.877 1.00 1.00 C +ATOM 1436 N2 G B 45 2.742 37.367 12.996 1.00 1.00 N +ATOM 1437 N3 G B 45 0.660 37.002 12.062 1.00 1.00 N +ATOM 1438 C4 G B 45 -0.374 36.129 12.062 1.00 1.00 C +ATOM 1439 H5' G B 45 -5.697 36.910 9.441 1.00 1.00 H +ATOM 1440 H5'' G B 45 -5.276 36.534 7.756 1.00 1.00 H +ATOM 1441 H4' G B 45 -3.836 38.312 8.542 1.00 1.00 H +ATOM 1442 H3' G B 45 -2.509 35.628 8.184 1.00 1.00 H +ATOM 1443 H2' G B 45 -0.493 36.438 9.019 1.00 1.00 H +ATOM 1444 HO2' G B 45 -1.037 39.130 9.107 1.00 1.00 H +ATOM 1445 H1' G B 45 -1.491 38.290 10.850 1.00 1.00 H +ATOM 1446 H8 G B 45 -3.263 34.952 11.213 1.00 1.00 H +ATOM 1447 H1 G B 45 2.396 35.243 14.223 1.00 1.00 H +ATOM 1448 H21 G B 45 3.490 37.072 13.613 1.00 1.00 H +ATOM 1449 H22 G B 45 2.830 38.223 12.471 1.00 1.00 H +ATOM 1450 P G B 46 -1.854 36.339 5.654 1.00 1.00 P +ATOM 1451 OP1 G B 46 -1.774 37.187 4.444 1.00 1.00 O +ATOM 1452 OP2 G B 46 -2.648 35.091 5.629 1.00 1.00 O +ATOM 1453 O5' G B 46 -0.352 35.975 6.113 1.00 1.00 O +ATOM 1454 C5' G B 46 0.674 36.971 6.117 1.00 1.00 C +ATOM 1455 C4' G B 46 2.035 36.374 6.470 1.00 1.00 C +ATOM 1456 O4' G B 46 2.110 36.099 7.864 1.00 1.00 O +ATOM 1457 C3' G B 46 2.345 35.066 5.759 1.00 1.00 C +ATOM 1458 O3' G B 46 3.030 35.335 4.529 1.00 1.00 O +ATOM 1459 C2' G B 46 3.285 34.351 6.714 1.00 1.00 C +ATOM 1460 O2' G B 46 4.652 34.506 6.319 1.00 1.00 O +ATOM 1461 C1' G B 46 3.013 35.004 8.066 1.00 1.00 C +ATOM 1462 N9 G B 46 2.436 34.090 9.069 1.00 1.00 N +ATOM 1463 C8 G B 46 1.124 33.859 9.388 1.00 1.00 C +ATOM 1464 N7 G B 46 0.957 32.993 10.349 1.00 1.00 N +ATOM 1465 C5 G B 46 2.254 32.621 10.693 1.00 1.00 C +ATOM 1466 C6 G B 46 2.708 31.703 11.680 1.00 1.00 C +ATOM 1467 O6 G B 46 2.039 31.026 12.458 1.00 1.00 O +ATOM 1468 N1 G B 46 4.093 31.620 11.699 1.00 1.00 N +ATOM 1469 C2 G B 46 4.940 32.331 10.875 1.00 1.00 C +ATOM 1470 N2 G B 46 6.243 32.116 11.042 1.00 1.00 N +ATOM 1471 N3 G B 46 4.515 33.194 9.947 1.00 1.00 N +ATOM 1472 C4 G B 46 3.166 33.288 9.914 1.00 1.00 C +ATOM 1473 H5' G B 46 0.423 37.736 6.852 1.00 1.00 H +ATOM 1474 H5'' G B 46 0.731 37.431 5.130 1.00 1.00 H +ATOM 1475 H4' G B 46 2.808 37.099 6.225 1.00 1.00 H +ATOM 1476 H3' G B 46 1.436 34.486 5.593 1.00 1.00 H +ATOM 1477 H2' G B 46 3.015 33.296 6.766 1.00 1.00 H +ATOM 1478 HO2' G B 46 5.195 34.289 7.080 1.00 1.00 H +ATOM 1479 H1' G B 46 3.953 35.394 8.456 1.00 1.00 H +ATOM 1480 H8 G B 46 0.293 34.354 8.885 1.00 1.00 H +ATOM 1481 H1 G B 46 4.491 30.985 12.378 1.00 1.00 H +ATOM 1482 H21 G B 46 6.563 31.463 11.743 1.00 1.00 H +ATOM 1483 H22 G B 46 6.914 32.608 10.467 1.00 1.00 H +ATOM 1484 P A B 47 3.293 34.155 3.464 1.00 1.00 P +ATOM 1485 OP1 A B 47 3.507 34.773 2.137 1.00 1.00 O +ATOM 1486 OP2 A B 47 2.243 33.128 3.640 1.00 1.00 O +ATOM 1487 O5' A B 47 4.697 33.527 3.955 1.00 1.00 O +ATOM 1488 C5' A B 47 5.932 34.211 3.718 1.00 1.00 C +ATOM 1489 C4' A B 47 7.124 33.429 4.270 1.00 1.00 C +ATOM 1490 O4' A B 47 7.037 33.364 5.690 1.00 1.00 O +ATOM 1491 C3' A B 47 7.216 31.995 3.771 1.00 1.00 C +ATOM 1492 O3' A B 47 8.063 31.943 2.618 1.00 1.00 O +ATOM 1493 C2' A B 47 7.867 31.253 4.929 1.00 1.00 C +ATOM 1494 O2' A B 47 9.290 31.207 4.784 1.00 1.00 O +ATOM 1495 C1' A B 47 7.456 32.070 6.151 1.00 1.00 C +ATOM 1496 N9 A B 47 6.326 31.493 6.894 1.00 1.00 N +ATOM 1497 C8 A B 47 4.986 31.570 6.609 1.00 1.00 C +ATOM 1498 N7 A B 47 4.227 30.946 7.466 1.00 1.00 N +ATOM 1499 C5 A B 47 5.127 30.416 8.385 1.00 1.00 C +ATOM 1500 C6 A B 47 4.953 29.641 9.544 1.00 1.00 C +ATOM 1501 N6 A B 47 3.758 29.252 9.988 1.00 1.00 N +ATOM 1502 N1 A B 47 6.059 29.287 10.220 1.00 1.00 N +ATOM 1503 C2 A B 47 7.246 29.679 9.771 1.00 1.00 C +ATOM 1504 N3 A B 47 7.538 30.406 8.702 1.00 1.00 N +ATOM 1505 C4 A B 47 6.408 30.745 8.045 1.00 1.00 C +ATOM 1506 H5' A B 47 5.897 35.191 4.196 1.00 1.00 H +ATOM 1507 H5'' A B 47 6.064 34.344 2.644 1.00 1.00 H +ATOM 1508 H4' A B 47 8.040 33.951 4.006 1.00 1.00 H +ATOM 1509 H3' A B 47 6.225 31.592 3.557 1.00 1.00 H +ATOM 1510 H2' A B 47 7.455 30.244 5.003 1.00 1.00 H +ATOM 1511 HO2' A B 47 9.638 32.038 5.113 1.00 1.00 H +ATOM 1512 H1' A B 47 8.309 32.180 6.821 1.00 1.00 H +ATOM 1513 H8 A B 47 4.593 32.105 5.744 1.00 1.00 H +ATOM 1514 H61 A B 47 3.688 28.695 10.826 1.00 1.00 H +ATOM 1515 H62 A B 47 2.922 29.513 9.484 1.00 1.00 H +ATOM 1516 H2 A B 47 8.101 29.357 10.367 1.00 1.00 H +ATOM 1517 P U B 48 7.769 30.899 1.428 1.00 1.00 P +ATOM 1518 OP1 U B 48 8.798 31.090 0.382 1.00 1.00 O +ATOM 1519 OP2 U B 48 6.335 30.991 1.079 1.00 1.00 O +ATOM 1520 O5' U B 48 8.025 29.475 2.132 1.00 1.00 O +ATOM 1521 C5' U B 48 9.327 29.118 2.602 1.00 1.00 C +ATOM 1522 C4' U B 48 9.268 27.916 3.538 1.00 1.00 C +ATOM 1523 O4' U B 48 8.489 28.239 4.686 1.00 1.00 O +ATOM 1524 C3' U B 48 8.638 26.678 2.922 1.00 1.00 C +ATOM 1525 O3' U B 48 9.663 25.869 2.332 1.00 1.00 O +ATOM 1526 C2' U B 48 8.010 25.959 4.107 1.00 1.00 C +ATOM 1527 O2' U B 48 8.878 24.948 4.627 1.00 1.00 O +ATOM 1528 C1' U B 48 7.783 27.074 5.133 1.00 1.00 C +ATOM 1529 N1 U B 48 6.364 27.458 5.298 1.00 1.00 N +ATOM 1530 C2 U B 48 5.660 26.886 6.339 1.00 1.00 C +ATOM 1531 O2 U B 48 6.176 26.081 7.111 1.00 1.00 O +ATOM 1532 N3 U B 48 4.337 27.270 6.462 1.00 1.00 N +ATOM 1533 C4 U B 48 3.668 28.166 5.647 1.00 1.00 C +ATOM 1534 O4 U B 48 2.486 28.436 5.851 1.00 1.00 O +ATOM 1535 C5 U B 48 4.480 28.716 4.585 1.00 1.00 C +ATOM 1536 C6 U B 48 5.778 28.353 4.443 1.00 1.00 C +ATOM 1537 H5' U B 48 9.758 29.965 3.136 1.00 1.00 H +ATOM 1538 H5'' U B 48 9.958 28.874 1.749 1.00 1.00 H +ATOM 1539 H4' U B 48 10.278 27.674 3.866 1.00 1.00 H +ATOM 1540 H3' U B 48 7.879 26.953 2.187 1.00 1.00 H +ATOM 1541 H2' U B 48 7.050 25.527 3.812 1.00 1.00 H +ATOM 1542 HO2' U B 48 8.332 24.312 5.092 1.00 1.00 H +ATOM 1543 H1' U B 48 8.185 26.760 6.097 1.00 1.00 H +ATOM 1544 H3 U B 48 3.811 26.859 7.219 1.00 1.00 H +ATOM 1545 H5 U B 48 4.042 29.432 3.888 1.00 1.00 H +ATOM 1546 H6 U B 48 6.368 28.784 3.634 1.00 1.00 H +ATOM 1547 P A B 49 9.309 24.773 1.206 1.00 1.00 P +ATOM 1548 OP1 A B 49 10.446 24.694 0.262 1.00 1.00 O +ATOM 1549 OP2 A B 49 7.947 25.054 0.698 1.00 1.00 O +ATOM 1550 O5' A B 49 9.259 23.404 2.053 1.00 1.00 O +ATOM 1551 C5' A B 49 10.097 23.238 3.200 1.00 1.00 C +ATOM 1552 C4' A B 49 10.005 21.824 3.767 1.00 1.00 C +ATOM 1553 O4' A B 49 8.656 21.558 4.168 1.00 1.00 O +ATOM 1554 C3' A B 49 10.419 20.733 2.774 1.00 1.00 C +ATOM 1555 O3' A B 49 11.399 19.876 3.378 1.00 1.00 O +ATOM 1556 C2' A B 49 9.141 19.948 2.511 1.00 1.00 C +ATOM 1557 O2' A B 49 9.406 18.548 2.382 1.00 1.00 O +ATOM 1558 C1' A B 49 8.292 20.250 3.733 1.00 1.00 C +ATOM 1559 N9 A B 49 6.836 20.234 3.486 1.00 1.00 N +ATOM 1560 C8 A B 49 6.123 20.862 2.498 1.00 1.00 C +ATOM 1561 N7 A B 49 4.837 20.647 2.558 1.00 1.00 N +ATOM 1562 C5 A B 49 4.691 19.817 3.666 1.00 1.00 C +ATOM 1563 C6 A B 49 3.568 19.228 4.269 1.00 1.00 C +ATOM 1564 N6 A B 49 2.324 19.394 3.817 1.00 1.00 N +ATOM 1565 N1 A B 49 3.781 18.461 5.352 1.00 1.00 N +ATOM 1566 C2 A B 49 5.021 18.298 5.797 1.00 1.00 C +ATOM 1567 N3 A B 49 6.152 18.797 5.320 1.00 1.00 N +ATOM 1568 C4 A B 49 5.905 19.560 4.235 1.00 1.00 C +ATOM 1569 H5' A B 49 9.791 23.947 3.968 1.00 1.00 H +ATOM 1570 H5'' A B 49 11.130 23.441 2.920 1.00 1.00 H +ATOM 1571 H4' A B 49 10.645 21.757 4.646 1.00 1.00 H +ATOM 1572 H3' A B 49 10.799 21.171 1.849 1.00 1.00 H +ATOM 1573 H2' A B 49 8.648 20.333 1.615 1.00 1.00 H +ATOM 1574 HO2' A B 49 9.465 18.183 3.268 1.00 1.00 H +ATOM 1575 H1' A B 49 8.529 19.536 4.518 1.00 1.00 H +ATOM 1576 H8 A B 49 6.588 21.482 1.730 1.00 1.00 H +ATOM 1577 H61 A B 49 1.552 18.945 4.291 1.00 1.00 H +ATOM 1578 H62 A B 49 2.148 19.968 3.004 1.00 1.00 H +ATOM 1579 H2 A B 49 5.124 17.665 6.677 1.00 1.00 H +ATOM 1580 P U B 50 11.115 19.130 4.780 1.00 1.00 P +ATOM 1581 OP1 U B 50 10.237 19.989 5.606 1.00 1.00 O +ATOM 1582 OP2 U B 50 12.409 18.664 5.326 1.00 1.00 O +ATOM 1583 O5' U B 50 10.270 17.838 4.325 1.00 1.00 O +ATOM 1584 C5' U B 50 9.507 17.089 5.269 1.00 1.00 C +ATOM 1585 C4' U B 50 8.597 16.076 4.579 1.00 1.00 C +ATOM 1586 O4' U B 50 7.930 16.696 3.472 1.00 1.00 O +ATOM 1587 C3' U B 50 9.342 14.845 4.040 1.00 1.00 C +ATOM 1588 O3' U B 50 8.729 13.638 4.518 1.00 1.00 O +ATOM 1589 C2' U B 50 9.167 14.928 2.530 1.00 1.00 C +ATOM 1590 O2' U B 50 8.974 13.633 1.952 1.00 1.00 O +ATOM 1591 C1' U B 50 7.930 15.792 2.368 1.00 1.00 C +ATOM 1592 N1 U B 50 7.891 16.597 1.123 1.00 1.00 N +ATOM 1593 C2 U B 50 8.436 16.045 -0.019 1.00 1.00 C +ATOM 1594 O2 U B 50 8.920 14.914 -0.031 1.00 1.00 O +ATOM 1595 N3 U B 50 8.409 16.839 -1.150 1.00 1.00 N +ATOM 1596 C4 U B 50 7.890 18.120 -1.237 1.00 1.00 C +ATOM 1597 O4 U B 50 7.918 18.736 -2.300 1.00 1.00 O +ATOM 1598 C5 U B 50 7.342 18.617 0.004 1.00 1.00 C +ATOM 1599 C6 U B 50 7.357 17.857 1.126 1.00 1.00 C +ATOM 1600 H5' U B 50 8.897 17.768 5.863 1.00 1.00 H +ATOM 1601 H5'' U B 50 10.190 16.556 5.932 1.00 1.00 H +ATOM 1602 H4' U B 50 7.844 15.759 5.287 1.00 1.00 H +ATOM 1603 H3' U B 50 10.400 14.881 4.308 1.00 1.00 H +ATOM 1604 H2' U B 50 10.027 15.429 2.084 1.00 1.00 H +ATOM 1605 HO2' U B 50 8.148 13.660 1.463 1.00 1.00 H +ATOM 1606 H1' U B 50 7.046 15.157 2.415 1.00 1.00 H +ATOM 1607 H3 U B 50 8.805 16.448 -1.993 1.00 1.00 H +ATOM 1608 H5 U B 50 6.909 19.616 0.039 1.00 1.00 H +ATOM 1609 H6 U B 50 6.938 18.258 2.049 1.00 1.00 H +ATOM 1610 P G B 51 8.359 13.450 6.075 1.00 1.00 P +ATOM 1611 OP1 G B 51 9.394 14.132 6.883 1.00 1.00 O +ATOM 1612 OP2 G B 51 8.054 12.021 6.310 1.00 1.00 O +ATOM 1613 O5' G B 51 6.991 14.297 6.192 1.00 1.00 O +ATOM 1614 C5' G B 51 5.911 13.846 7.015 1.00 1.00 C +ATOM 1615 C4' G B 51 4.690 13.466 6.178 1.00 1.00 C +ATOM 1616 O4' G B 51 4.032 14.634 5.693 1.00 1.00 O +ATOM 1617 C3' G B 51 5.020 12.609 4.971 1.00 1.00 C +ATOM 1618 O3' G B 51 4.921 11.229 5.328 1.00 1.00 O +ATOM 1619 C2' G B 51 3.947 12.976 3.954 1.00 1.00 C +ATOM 1620 O2' G B 51 2.844 12.065 4.004 1.00 1.00 O +ATOM 1621 C1' G B 51 3.524 14.388 4.370 1.00 1.00 C +ATOM 1622 N9 G B 51 4.053 15.457 3.502 1.00 1.00 N +ATOM 1623 C8 G B 51 5.151 16.252 3.716 1.00 1.00 C +ATOM 1624 N7 G B 51 5.376 17.109 2.761 1.00 1.00 N +ATOM 1625 C5 G B 51 4.356 16.870 1.846 1.00 1.00 C +ATOM 1626 C6 G B 51 4.083 17.500 0.601 1.00 1.00 C +ATOM 1627 O6 G B 51 4.702 18.411 0.054 1.00 1.00 O +ATOM 1628 N1 G B 51 2.959 16.958 -0.009 1.00 1.00 N +ATOM 1629 C2 G B 51 2.192 15.939 0.511 1.00 1.00 C +ATOM 1630 N2 G B 51 1.150 15.552 -0.224 1.00 1.00 N +ATOM 1631 N3 G B 51 2.447 15.343 1.682 1.00 1.00 N +ATOM 1632 C4 G B 51 3.541 15.858 2.291 1.00 1.00 C +ATOM 1633 H5' G B 51 5.634 14.646 7.702 1.00 1.00 H +ATOM 1634 H5'' G B 51 6.237 12.980 7.589 1.00 1.00 H +ATOM 1635 H4' G B 51 3.993 12.920 6.813 1.00 1.00 H +ATOM 1636 H3' G B 51 6.013 12.848 4.587 1.00 1.00 H +ATOM 1637 H2' G B 51 4.381 13.001 2.951 1.00 1.00 H +ATOM 1638 HO2' G B 51 2.422 12.078 3.142 1.00 1.00 H +ATOM 1639 H1' G B 51 2.438 14.448 4.383 1.00 1.00 H +ATOM 1640 H8 G B 51 5.776 16.174 4.605 1.00 1.00 H +ATOM 1641 H1 G B 51 2.702 17.357 -0.900 1.00 1.00 H +ATOM 1642 H21 G B 51 0.958 16.004 -1.109 1.00 1.00 H +ATOM 1643 H22 G B 51 0.548 14.810 0.103 1.00 1.00 H +ATOM 1644 P G B 52 5.777 10.120 4.540 1.00 1.00 P +ATOM 1645 OP1 G B 52 5.920 8.936 5.417 1.00 1.00 O +ATOM 1646 OP2 G B 52 6.981 10.775 3.980 1.00 1.00 O +ATOM 1647 O5' G B 52 4.797 9.731 3.326 1.00 1.00 O +ATOM 1648 C5' G B 52 5.010 10.274 2.024 1.00 1.00 C +ATOM 1649 C4' G B 52 3.692 10.692 1.368 1.00 1.00 C +ATOM 1650 O4' G B 52 3.554 12.125 1.411 1.00 1.00 O +ATOM 1651 C3' G B 52 3.567 10.265 -0.095 1.00 1.00 C +ATOM 1652 O3' G B 52 2.790 9.068 -0.180 1.00 1.00 O +ATOM 1653 C2' G B 52 2.813 11.408 -0.743 1.00 1.00 C +ATOM 1654 O2' G B 52 1.398 11.192 -0.701 1.00 1.00 O +ATOM 1655 C1' G B 52 3.216 12.604 0.103 1.00 1.00 C +ATOM 1656 N9 G B 52 4.382 13.335 -0.420 1.00 1.00 N +ATOM 1657 C8 G B 52 5.590 13.574 0.183 1.00 1.00 C +ATOM 1658 N7 G B 52 6.420 14.261 -0.551 1.00 1.00 N +ATOM 1659 C5 G B 52 5.712 14.498 -1.725 1.00 1.00 C +ATOM 1660 C6 G B 52 6.101 15.202 -2.899 1.00 1.00 C +ATOM 1661 O6 G B 52 7.169 15.763 -3.134 1.00 1.00 O +ATOM 1662 N1 G B 52 5.088 15.207 -3.849 1.00 1.00 N +ATOM 1663 C2 G B 52 3.854 14.613 -3.693 1.00 1.00 C +ATOM 1664 N2 G B 52 3.010 14.726 -4.719 1.00 1.00 N +ATOM 1665 N3 G B 52 3.486 13.951 -2.591 1.00 1.00 N +ATOM 1666 C4 G B 52 4.462 13.935 -1.654 1.00 1.00 C +ATOM 1667 H5' G B 52 5.499 9.521 1.406 1.00 1.00 H +ATOM 1668 H5'' G B 52 5.662 11.144 2.104 1.00 1.00 H +ATOM 1669 H4' G B 52 2.869 10.252 1.930 1.00 1.00 H +ATOM 1670 H3' G B 52 4.548 10.137 -0.554 1.00 1.00 H +ATOM 1671 H2' G B 52 3.154 11.546 -1.771 1.00 1.00 H +ATOM 1672 HO2' G B 52 1.242 10.271 -0.922 1.00 1.00 H +ATOM 1673 H1' G B 52 2.373 13.288 0.181 1.00 1.00 H +ATOM 1674 H8 G B 52 5.836 13.221 1.185 1.00 1.00 H +ATOM 1675 H1 G B 52 5.291 15.690 -4.712 1.00 1.00 H +ATOM 1676 H21 G B 52 3.289 15.224 -5.548 1.00 1.00 H +ATOM 1677 H22 G B 52 2.092 14.310 -4.664 1.00 1.00 H +ATOM 1678 P A B 53 3.374 7.772 -0.934 1.00 1.00 P +ATOM 1679 OP1 A B 53 2.382 6.682 -0.810 1.00 1.00 O +ATOM 1680 OP2 A B 53 4.766 7.560 -0.479 1.00 1.00 O +ATOM 1681 O5' A B 53 3.412 8.242 -2.473 1.00 1.00 O +ATOM 1682 C5' A B 53 2.197 8.449 -3.197 1.00 1.00 C +ATOM 1683 C4' A B 53 2.466 8.789 -4.659 1.00 1.00 C +ATOM 1684 O4' A B 53 2.671 10.189 -4.807 1.00 1.00 O +ATOM 1685 C3' A B 53 3.695 8.111 -5.240 1.00 1.00 C +ATOM 1686 O3' A B 53 3.336 6.845 -5.802 1.00 1.00 O +ATOM 1687 C2' A B 53 4.141 9.064 -6.337 1.00 1.00 C +ATOM 1688 O2' A B 53 3.613 8.677 -7.611 1.00 1.00 O +ATOM 1689 C1' A B 53 3.583 10.417 -5.891 1.00 1.00 C +ATOM 1690 N9 A B 53 4.609 11.355 -5.410 1.00 1.00 N +ATOM 1691 C8 A B 53 5.092 11.528 -4.138 1.00 1.00 C +ATOM 1692 N7 A B 53 6.005 12.456 -4.042 1.00 1.00 N +ATOM 1693 C5 A B 53 6.136 12.929 -5.344 1.00 1.00 C +ATOM 1694 C6 A B 53 6.949 13.923 -5.916 1.00 1.00 C +ATOM 1695 N6 A B 53 7.817 14.650 -5.212 1.00 1.00 N +ATOM 1696 N1 A B 53 6.826 14.135 -7.237 1.00 1.00 N +ATOM 1697 C2 A B 53 5.958 13.409 -7.932 1.00 1.00 C +ATOM 1698 N3 A B 53 5.144 12.453 -7.512 1.00 1.00 N +ATOM 1699 C4 A B 53 5.291 12.262 -6.184 1.00 1.00 C +ATOM 1700 H5' A B 53 1.648 9.271 -2.740 1.00 1.00 H +ATOM 1701 H5'' A B 53 1.592 7.545 -3.146 1.00 1.00 H +ATOM 1702 H4' A B 53 1.597 8.507 -5.250 1.00 1.00 H +ATOM 1703 H3' A B 53 4.472 8.003 -4.481 1.00 1.00 H +ATOM 1704 H2' A B 53 5.230 9.108 -6.369 1.00 1.00 H +ATOM 1705 HO2' A B 53 4.070 9.194 -8.279 1.00 1.00 H +ATOM 1706 H1' A B 53 3.047 10.872 -6.722 1.00 1.00 H +ATOM 1707 H8 A B 53 4.744 10.944 -3.284 1.00 1.00 H +ATOM 1708 H61 A B 53 8.378 15.354 -5.675 1.00 1.00 H +ATOM 1709 H62 A B 53 7.917 14.498 -4.219 1.00 1.00 H +ATOM 1710 H2 A B 53 5.910 13.632 -8.997 1.00 1.00 H +ATOM 1711 P A B 54 4.461 5.727 -6.077 1.00 1.00 P +ATOM 1712 OP1 A B 54 3.782 4.465 -6.445 1.00 1.00 O +ATOM 1713 OP2 A B 54 5.422 5.748 -4.950 1.00 1.00 O +ATOM 1714 O5' A B 54 5.209 6.295 -7.385 1.00 1.00 O +ATOM 1715 C5' A B 54 4.512 6.406 -8.629 1.00 1.00 C +ATOM 1716 C4' A B 54 5.393 7.022 -9.711 1.00 1.00 C +ATOM 1717 O4' A B 54 5.702 8.370 -9.376 1.00 1.00 O +ATOM 1718 C3' A B 54 6.722 6.315 -9.912 1.00 1.00 C +ATOM 1719 O3' A B 54 6.584 5.268 -10.882 1.00 1.00 O +ATOM 1720 C2' A B 54 7.617 7.415 -10.451 1.00 1.00 C +ATOM 1721 O2' A B 54 7.604 7.454 -11.882 1.00 1.00 O +ATOM 1722 C1' A B 54 7.021 8.684 -9.847 1.00 1.00 C +ATOM 1723 N9 A B 54 7.788 9.203 -8.704 1.00 1.00 N +ATOM 1724 C8 A B 54 7.753 8.800 -7.393 1.00 1.00 C +ATOM 1725 N7 A B 54 8.578 9.450 -6.620 1.00 1.00 N +ATOM 1726 C5 A B 54 9.203 10.347 -7.480 1.00 1.00 C +ATOM 1727 C6 A B 54 10.191 11.325 -7.277 1.00 1.00 C +ATOM 1728 N6 A B 54 10.746 11.565 -6.088 1.00 1.00 N +ATOM 1729 N1 A B 54 10.582 12.038 -8.347 1.00 1.00 N +ATOM 1730 C2 A B 54 10.030 11.788 -9.527 1.00 1.00 C +ATOM 1731 N3 A B 54 9.099 10.901 -9.845 1.00 1.00 N +ATOM 1732 C4 A B 54 8.727 10.203 -8.751 1.00 1.00 C +ATOM 1733 H5' A B 54 3.631 7.032 -8.489 1.00 1.00 H +ATOM 1734 H5'' A B 54 4.195 5.412 -8.950 1.00 1.00 H +ATOM 1735 H4' A B 54 4.847 7.021 -10.652 1.00 1.00 H +ATOM 1736 H3' A B 54 7.106 5.932 -8.964 1.00 1.00 H +ATOM 1737 H2' A B 54 8.628 7.280 -10.078 1.00 1.00 H +ATOM 1738 HO2' A B 54 8.518 7.466 -12.177 1.00 1.00 H +ATOM 1739 H1' A B 54 6.960 9.453 -10.615 1.00 1.00 H +ATOM 1740 H8 A B 54 7.097 8.009 -7.031 1.00 1.00 H +ATOM 1741 H61 A B 54 11.454 12.281 -5.997 1.00 1.00 H +ATOM 1742 H62 A B 54 10.458 11.034 -5.282 1.00 1.00 H +ATOM 1743 H2 A B 54 10.394 12.401 -10.352 1.00 1.00 H +ATOM 1744 P G B 55 7.460 3.920 -10.765 1.00 1.00 P +ATOM 1745 OP1 G B 55 6.774 2.857 -11.533 1.00 1.00 O +ATOM 1746 OP2 G B 55 7.786 3.703 -9.337 1.00 1.00 O +ATOM 1747 O5' G B 55 8.821 4.301 -11.540 1.00 1.00 O +ATOM 1748 C5' G B 55 8.888 4.247 -12.969 1.00 1.00 C +ATOM 1749 C4' G B 55 10.116 4.983 -13.504 1.00 1.00 C +ATOM 1750 O4' G B 55 10.160 6.303 -12.967 1.00 1.00 O +ATOM 1751 C3' G B 55 11.448 4.332 -13.159 1.00 1.00 C +ATOM 1752 O3' G B 55 11.820 3.412 -14.192 1.00 1.00 O +ATOM 1753 C2' G B 55 12.411 5.509 -13.134 1.00 1.00 C +ATOM 1754 O2' G B 55 12.997 5.739 -14.422 1.00 1.00 O +ATOM 1755 C1' G B 55 11.525 6.666 -12.705 1.00 1.00 C +ATOM 1756 N9 G B 55 11.633 6.977 -11.272 1.00 1.00 N +ATOM 1757 C8 G B 55 10.976 6.403 -10.215 1.00 1.00 C +ATOM 1758 N7 G B 55 11.279 6.923 -9.059 1.00 1.00 N +ATOM 1759 C5 G B 55 12.206 7.913 -9.370 1.00 1.00 C +ATOM 1760 C6 G B 55 12.895 8.818 -8.515 1.00 1.00 C +ATOM 1761 O6 G B 55 12.816 8.923 -7.293 1.00 1.00 O +ATOM 1762 N1 G B 55 13.742 9.651 -9.232 1.00 1.00 N +ATOM 1763 C2 G B 55 13.908 9.622 -10.600 1.00 1.00 C +ATOM 1764 N2 G B 55 14.772 10.501 -11.107 1.00 1.00 N +ATOM 1765 N3 G B 55 13.260 8.775 -11.406 1.00 1.00 N +ATOM 1766 C4 G B 55 12.430 7.953 -10.724 1.00 1.00 C +ATOM 1767 H5' G B 55 7.989 4.705 -13.385 1.00 1.00 H +ATOM 1768 H5'' G B 55 8.932 3.204 -13.284 1.00 1.00 H +ATOM 1769 H4' G B 55 10.034 5.058 -14.587 1.00 1.00 H +ATOM 1770 H3' G B 55 11.404 3.842 -12.184 1.00 1.00 H +ATOM 1771 H2' G B 55 13.183 5.353 -12.380 1.00 1.00 H +ATOM 1772 HO2' G B 55 12.279 5.869 -15.044 1.00 1.00 H +ATOM 1773 H1' G B 55 11.782 7.552 -13.284 1.00 1.00 H +ATOM 1774 H8 G B 55 10.266 5.584 -10.330 1.00 1.00 H +ATOM 1775 H1 G B 55 14.266 10.324 -8.691 1.00 1.00 H +ATOM 1776 H21 G B 55 15.259 11.139 -10.496 1.00 1.00 H +ATOM 1777 H22 G B 55 14.937 10.527 -12.103 1.00 1.00 H +ATOM 1778 P A B 56 12.793 2.167 -13.873 1.00 1.00 P +ATOM 1779 OP1 A B 56 12.919 1.356 -15.105 1.00 1.00 O +ATOM 1780 OP2 A B 56 12.342 1.532 -12.616 1.00 1.00 O +ATOM 1781 O5' A B 56 14.213 2.876 -13.598 1.00 1.00 O +ATOM 1782 C5' A B 56 14.991 3.398 -14.678 1.00 1.00 C +ATOM 1783 C4' A B 56 16.238 4.117 -14.174 1.00 1.00 C +ATOM 1784 O4' A B 56 15.863 5.260 -13.410 1.00 1.00 O +ATOM 1785 C3' A B 56 17.130 3.276 -13.274 1.00 1.00 C +ATOM 1786 O3' A B 56 18.077 2.551 -14.069 1.00 1.00 O +ATOM 1787 C2' A B 56 17.836 4.325 -12.426 1.00 1.00 C +ATOM 1788 O2' A B 56 19.048 4.774 -13.044 1.00 1.00 O +ATOM 1789 C1' A B 56 16.801 5.449 -12.340 1.00 1.00 C +ATOM 1790 N9 A B 56 16.035 5.455 -11.084 1.00 1.00 N +ATOM 1791 C8 A B 56 14.980 4.665 -10.708 1.00 1.00 C +ATOM 1792 N7 A B 56 14.520 4.931 -9.516 1.00 1.00 N +ATOM 1793 C5 A B 56 15.330 5.972 -9.072 1.00 1.00 C +ATOM 1794 C6 A B 56 15.359 6.707 -7.876 1.00 1.00 C +ATOM 1795 N6 A B 56 14.514 6.491 -6.866 1.00 1.00 N +ATOM 1796 N1 A B 56 16.292 7.668 -7.765 1.00 1.00 N +ATOM 1797 C2 A B 56 17.130 7.876 -8.773 1.00 1.00 C +ATOM 1798 N3 A B 56 17.203 7.256 -9.941 1.00 1.00 N +ATOM 1799 C4 A B 56 16.255 6.298 -10.022 1.00 1.00 C +ATOM 1800 H5' A B 56 14.383 4.099 -15.251 1.00 1.00 H +ATOM 1801 H5'' A B 56 15.292 2.576 -15.328 1.00 1.00 H +ATOM 1802 H4' A B 56 16.821 4.454 -15.029 1.00 1.00 H +ATOM 1803 H3' A B 56 16.534 2.606 -12.650 1.00 1.00 H +ATOM 1804 H2' A B 56 18.035 3.928 -11.432 1.00 1.00 H +ATOM 1805 HO2' A B 56 18.949 4.655 -13.989 1.00 1.00 H +ATOM 1806 H1' A B 56 17.297 6.413 -12.456 1.00 1.00 H +ATOM 1807 H8 A B 56 14.563 3.885 -11.346 1.00 1.00 H +ATOM 1808 H61 A B 56 14.582 7.057 -6.020 1.00 1.00 H +ATOM 1809 H62 A B 56 13.809 5.771 -6.939 1.00 1.00 H +ATOM 1810 H2 A B 56 17.861 8.670 -8.617 1.00 1.00 H +ATOM 1811 P A B 57 18.388 0.994 -13.772 1.00 1.00 P +ATOM 1812 OP1 A B 57 19.293 0.497 -14.832 1.00 1.00 O +ATOM 1813 OP2 A B 57 17.103 0.305 -13.516 1.00 1.00 O +ATOM 1814 O5' A B 57 19.215 1.044 -12.392 1.00 1.00 O +ATOM 1815 C5' A B 57 20.610 1.357 -12.395 1.00 1.00 C +ATOM 1816 C4' A B 57 21.120 1.674 -10.991 1.00 1.00 C +ATOM 1817 O4' A B 57 20.409 2.786 -10.456 1.00 1.00 O +ATOM 1818 C3' A B 57 20.948 0.547 -9.986 1.00 1.00 C +ATOM 1819 O3' A B 57 22.089 -0.321 -10.009 1.00 1.00 O +ATOM 1820 C2' A B 57 20.877 1.275 -8.658 1.00 1.00 C +ATOM 1821 O2' A B 57 22.162 1.349 -8.030 1.00 1.00 O +ATOM 1822 C1' A B 57 20.347 2.657 -9.028 1.00 1.00 C +ATOM 1823 N9 A B 57 18.948 2.876 -8.621 1.00 1.00 N +ATOM 1824 C8 A B 57 17.796 2.542 -9.285 1.00 1.00 C +ATOM 1825 N7 A B 57 16.706 2.893 -8.659 1.00 1.00 N +ATOM 1826 C5 A B 57 17.171 3.502 -7.498 1.00 1.00 C +ATOM 1827 C6 A B 57 16.511 4.092 -6.406 1.00 1.00 C +ATOM 1828 N6 A B 57 15.184 4.167 -6.308 1.00 1.00 N +ATOM 1829 N1 A B 57 17.277 4.601 -5.425 1.00 1.00 N +ATOM 1830 C2 A B 57 18.599 4.524 -5.528 1.00 1.00 C +ATOM 1831 N3 A B 57 19.332 3.998 -6.497 1.00 1.00 N +ATOM 1832 C4 A B 57 18.536 3.497 -7.466 1.00 1.00 C +ATOM 1833 H5' A B 57 20.781 2.219 -13.040 1.00 1.00 H +ATOM 1834 H5'' A B 57 21.163 0.502 -12.789 1.00 1.00 H +ATOM 1835 H4' A B 57 22.173 1.940 -11.048 1.00 1.00 H +ATOM 1836 H3' A B 57 20.025 -0.005 -10.175 1.00 1.00 H +ATOM 1837 H2' A B 57 20.164 0.779 -8.015 1.00 1.00 H +ATOM 1838 HO2' A B 57 22.490 2.241 -8.157 1.00 1.00 H +ATOM 1839 H1' A B 57 20.974 3.421 -8.567 1.00 1.00 H +ATOM 1840 H8 A B 57 17.790 2.028 -10.246 1.00 1.00 H +ATOM 1841 H61 A B 57 14.766 4.599 -5.510 1.00 1.00 H +ATOM 1842 H62 A B 57 14.600 3.788 -7.041 1.00 1.00 H +ATOM 1843 H2 A B 57 19.158 4.955 -4.698 1.00 1.00 H +ATOM 1844 P C B 58 21.998 -1.815 -9.402 1.00 1.00 P +ATOM 1845 OP1 C B 58 23.263 -2.517 -9.713 1.00 1.00 O +ATOM 1846 OP2 C B 58 20.705 -2.404 -9.819 1.00 1.00 O +ATOM 1847 O5' C B 58 21.940 -1.564 -7.811 1.00 1.00 O +ATOM 1848 C5' C B 58 23.133 -1.289 -7.069 1.00 1.00 C +ATOM 1849 C4' C B 58 22.827 -0.997 -5.602 1.00 1.00 C +ATOM 1850 O4' C B 58 21.997 0.146 -5.507 1.00 1.00 O +ATOM 1851 C3' C B 58 22.088 -2.099 -4.867 1.00 1.00 C +ATOM 1852 O3' C B 58 23.019 -3.042 -4.326 1.00 1.00 O +ATOM 1853 C2' C B 58 21.388 -1.346 -3.742 1.00 1.00 C +ATOM 1854 O2' C B 58 22.185 -1.315 -2.554 1.00 1.00 O +ATOM 1855 C1' C B 58 21.190 0.059 -4.320 1.00 1.00 C +ATOM 1856 N1 C B 58 19.798 0.333 -4.730 1.00 1.00 N +ATOM 1857 C2 C B 58 19.024 1.149 -3.919 1.00 1.00 C +ATOM 1858 O2 C B 58 19.500 1.629 -2.893 1.00 1.00 O +ATOM 1859 N3 C B 58 17.738 1.398 -4.295 1.00 1.00 N +ATOM 1860 C4 C B 58 17.235 0.870 -5.419 1.00 1.00 C +ATOM 1861 N4 C B 58 15.972 1.131 -5.757 1.00 1.00 N +ATOM 1862 C5 C B 58 18.032 0.029 -6.258 1.00 1.00 C +ATOM 1863 C6 C B 58 19.301 -0.210 -5.878 1.00 1.00 C +ATOM 1864 H5' C B 58 23.632 -0.424 -7.507 1.00 1.00 H +ATOM 1865 H5'' C B 58 23.797 -2.151 -7.129 1.00 1.00 H +ATOM 1866 H4' C B 58 23.758 -0.785 -5.082 1.00 1.00 H +ATOM 1867 H3' C B 58 21.362 -2.583 -5.522 1.00 1.00 H +ATOM 1868 H2' C B 58 20.417 -1.801 -3.540 1.00 1.00 H +ATOM 1869 HO2' C B 58 23.101 -1.420 -2.821 1.00 1.00 H +ATOM 1870 H1' C B 58 21.517 0.802 -3.595 1.00 1.00 H +ATOM 1871 H41 C B 58 15.404 1.724 -5.169 1.00 1.00 H +ATOM 1872 H42 C B 58 15.584 0.737 -6.602 1.00 1.00 H +ATOM 1873 H5 C B 58 17.627 -0.398 -7.175 1.00 1.00 H +ATOM 1874 H6 C B 58 19.938 -0.845 -6.495 1.00 1.00 H +ATOM 1875 P C B 59 22.545 -4.543 -3.981 1.00 1.00 P +ATOM 1876 OP1 C B 59 23.685 -5.259 -3.363 1.00 1.00 O +ATOM 1877 OP2 C B 59 21.880 -5.105 -5.177 1.00 1.00 O +ATOM 1878 O5' C B 59 21.428 -4.295 -2.847 1.00 1.00 O +ATOM 1879 C5' C B 59 21.802 -3.755 -1.578 1.00 1.00 C +ATOM 1880 C4' C B 59 20.615 -3.120 -0.857 1.00 1.00 C +ATOM 1881 O4' C B 59 19.966 -2.193 -1.713 1.00 1.00 O +ATOM 1882 C3' C B 59 19.542 -4.094 -0.411 1.00 1.00 C +ATOM 1883 O3' C B 59 19.833 -4.557 0.912 1.00 1.00 O +ATOM 1884 C2' C B 59 18.281 -3.245 -0.382 1.00 1.00 C +ATOM 1885 O2' C B 59 17.976 -2.799 0.942 1.00 1.00 O +ATOM 1886 C1' C B 59 18.595 -2.071 -1.310 1.00 1.00 C +ATOM 1887 N1 C B 59 17.743 -2.009 -2.521 1.00 1.00 N +ATOM 1888 C2 C B 59 16.663 -1.140 -2.487 1.00 1.00 C +ATOM 1889 O2 C B 59 16.443 -0.472 -1.480 1.00 1.00 O +ATOM 1890 N3 C B 59 15.867 -1.057 -3.587 1.00 1.00 N +ATOM 1891 C4 C B 59 16.117 -1.796 -4.676 1.00 1.00 C +ATOM 1892 N4 C B 59 15.316 -1.689 -5.735 1.00 1.00 N +ATOM 1893 C5 C B 59 17.228 -2.695 -4.715 1.00 1.00 C +ATOM 1894 C6 C B 59 18.012 -2.771 -3.622 1.00 1.00 C +ATOM 1895 H5' C B 59 22.572 -2.998 -1.729 1.00 1.00 H +ATOM 1896 H5'' C B 59 22.208 -4.554 -0.957 1.00 1.00 H +ATOM 1897 H4' C B 59 20.982 -2.577 0.012 1.00 1.00 H +ATOM 1898 H3' C B 59 19.444 -4.922 -1.114 1.00 1.00 H +ATOM 1899 H2' C B 59 17.454 -3.817 -0.798 1.00 1.00 H +ATOM 1900 HO2' C B 59 18.391 -1.941 1.055 1.00 1.00 H +ATOM 1901 H1' C B 59 18.483 -1.144 -0.744 1.00 1.00 H +ATOM 1902 H41 C B 59 14.527 -1.054 -5.712 1.00 1.00 H +ATOM 1903 H42 C B 59 15.496 -2.242 -6.562 1.00 1.00 H +ATOM 1904 H5 C B 59 17.435 -3.297 -5.601 1.00 1.00 H +ATOM 1905 H6 C B 59 18.868 -3.447 -3.617 1.00 1.00 H +ATOM 1906 P G B 60 18.956 -5.728 1.582 1.00 1.00 P +ATOM 1907 OP1 G B 60 19.726 -6.291 2.713 1.00 1.00 O +ATOM 1908 OP2 G B 60 18.469 -6.617 0.503 1.00 1.00 O +ATOM 1909 O5' G B 60 17.694 -4.923 2.182 1.00 1.00 O +ATOM 1910 C5' G B 60 17.874 -3.954 3.219 1.00 1.00 C +ATOM 1911 C4' G B 60 16.540 -3.380 3.695 1.00 1.00 C +ATOM 1912 O4' G B 60 15.944 -2.587 2.671 1.00 1.00 O +ATOM 1913 C3' G B 60 15.507 -4.425 4.076 1.00 1.00 C +ATOM 1914 O3' G B 60 15.644 -4.774 5.455 1.00 1.00 O +ATOM 1915 C2' G B 60 14.183 -3.715 3.850 1.00 1.00 C +ATOM 1916 O2' G B 60 13.710 -3.094 5.046 1.00 1.00 O +ATOM 1917 C1' G B 60 14.513 -2.678 2.780 1.00 1.00 C +ATOM 1918 N9 G B 60 13.994 -3.026 1.453 1.00 1.00 N +ATOM 1919 C8 G B 60 14.651 -3.644 0.420 1.00 1.00 C +ATOM 1920 N7 G B 60 13.918 -3.821 -0.644 1.00 1.00 N +ATOM 1921 C5 G B 60 12.684 -3.283 -0.294 1.00 1.00 C +ATOM 1922 C6 G B 60 11.483 -3.187 -1.051 1.00 1.00 C +ATOM 1923 O6 G B 60 11.274 -3.570 -2.200 1.00 1.00 O +ATOM 1924 N1 G B 60 10.470 -2.575 -0.326 1.00 1.00 N +ATOM 1925 C2 G B 60 10.592 -2.110 0.966 1.00 1.00 C +ATOM 1926 N2 G B 60 9.505 -1.552 1.496 1.00 1.00 N +ATOM 1927 N3 G B 60 11.720 -2.198 1.680 1.00 1.00 N +ATOM 1928 C4 G B 60 12.720 -2.793 0.988 1.00 1.00 C +ATOM 1929 H5' G B 60 18.495 -3.141 2.840 1.00 1.00 H +ATOM 1930 H5'' G B 60 18.382 -4.425 4.062 1.00 1.00 H +ATOM 1931 H4' G B 60 16.722 -2.741 4.557 1.00 1.00 H +ATOM 1932 H3' G B 60 15.591 -5.304 3.434 1.00 1.00 H +ATOM 1933 H2' G B 60 13.448 -4.418 3.463 1.00 1.00 H +ATOM 1934 HO2' G B 60 13.814 -2.146 4.937 1.00 1.00 H +ATOM 1935 H1' G B 60 14.109 -1.711 3.080 1.00 1.00 H +ATOM 1936 H8 G B 60 15.692 -3.959 0.483 1.00 1.00 H +ATOM 1937 H1 G B 60 9.584 -2.473 -0.799 1.00 1.00 H +ATOM 1938 H21 G B 60 8.656 -1.489 0.953 1.00 1.00 H +ATOM 1939 H22 G B 60 9.530 -1.192 2.440 1.00 1.00 H +ATOM 1940 P G B 61 15.006 -6.142 6.014 1.00 1.00 P +ATOM 1941 OP1 G B 61 15.386 -6.282 7.437 1.00 1.00 O +ATOM 1942 OP2 G B 61 15.320 -7.225 5.055 1.00 1.00 O +ATOM 1943 O5' G B 61 13.424 -5.844 5.941 1.00 1.00 O +ATOM 1944 C5' G B 61 12.845 -4.796 6.724 1.00 1.00 C +ATOM 1945 C4' G B 61 11.345 -4.662 6.471 1.00 1.00 C +ATOM 1946 O4' G B 61 11.100 -4.242 5.132 1.00 1.00 O +ATOM 1947 C3' G B 61 10.560 -5.946 6.661 1.00 1.00 C +ATOM 1948 O3' G B 61 10.141 -6.053 8.024 1.00 1.00 O +ATOM 1949 C2' G B 61 9.353 -5.767 5.753 1.00 1.00 C +ATOM 1950 O2' G B 61 8.214 -5.294 6.477 1.00 1.00 O +ATOM 1951 C1' G B 61 9.822 -4.748 4.715 1.00 1.00 C +ATOM 1952 N9 G B 61 9.979 -5.310 3.361 1.00 1.00 N +ATOM 1953 C8 G B 61 11.062 -5.944 2.813 1.00 1.00 C +ATOM 1954 N7 G B 61 10.886 -6.319 1.577 1.00 1.00 N +ATOM 1955 C5 G B 61 9.591 -5.905 1.280 1.00 1.00 C +ATOM 1956 C6 G B 61 8.844 -6.039 0.077 1.00 1.00 C +ATOM 1957 O6 G B 61 9.188 -6.562 -0.981 1.00 1.00 O +ATOM 1958 N1 G B 61 7.576 -5.486 0.201 1.00 1.00 N +ATOM 1959 C2 G B 61 7.085 -4.877 1.336 1.00 1.00 C +ATOM 1960 N2 G B 61 5.842 -4.405 1.260 1.00 1.00 N +ATOM 1961 N3 G B 61 7.786 -4.751 2.468 1.00 1.00 N +ATOM 1962 C4 G B 61 9.026 -5.286 2.368 1.00 1.00 C +ATOM 1963 H5' G B 61 13.333 -3.854 6.472 1.00 1.00 H +ATOM 1964 H5'' G B 61 13.009 -5.010 7.780 1.00 1.00 H +ATOM 1965 H4' G B 61 10.944 -3.903 7.142 1.00 1.00 H +ATOM 1966 H3' G B 61 11.151 -6.811 6.357 1.00 1.00 H +ATOM 1967 H2' G B 61 9.127 -6.706 5.255 1.00 1.00 H +ATOM 1968 HO2' G B 61 8.399 -4.393 6.749 1.00 1.00 H +ATOM 1969 H1' G B 61 9.108 -3.927 4.676 1.00 1.00 H +ATOM 1970 H8 G B 61 11.990 -6.117 3.359 1.00 1.00 H +ATOM 1971 H1 G B 61 6.985 -5.544 -0.617 1.00 1.00 H +ATOM 1972 H21 G B 61 5.316 -4.503 0.403 1.00 1.00 H +ATOM 1973 H22 G B 61 5.426 -3.949 2.059 1.00 1.00 H +ATOM 1974 P G B 62 9.691 -7.471 8.640 1.00 1.00 P +ATOM 1975 OP1 G B 62 9.531 -7.308 10.102 1.00 1.00 O +ATOM 1976 OP2 G B 62 10.594 -8.514 8.107 1.00 1.00 O +ATOM 1977 O5' G B 62 8.230 -7.693 7.995 1.00 1.00 O +ATOM 1978 C5' G B 62 7.158 -6.789 8.285 1.00 1.00 C +ATOM 1979 C4' G B 62 5.924 -7.096 7.439 1.00 1.00 C +ATOM 1980 O4' G B 62 6.210 -6.889 6.065 1.00 1.00 O +ATOM 1981 C3' G B 62 5.425 -8.524 7.559 1.00 1.00 C +ATOM 1982 O3' G B 62 4.492 -8.613 8.643 1.00 1.00 O +ATOM 1983 C2' G B 62 4.721 -8.766 6.227 1.00 1.00 C +ATOM 1984 O2' G B 62 3.314 -8.532 6.332 1.00 1.00 O +ATOM 1985 C1' G B 62 5.386 -7.761 5.276 1.00 1.00 C +ATOM 1986 N9 G B 62 6.256 -8.380 4.261 1.00 1.00 N +ATOM 1987 C8 G B 62 7.560 -8.781 4.380 1.00 1.00 C +ATOM 1988 N7 G B 62 8.058 -9.293 3.289 1.00 1.00 N +ATOM 1989 C5 G B 62 7.008 -9.225 2.377 1.00 1.00 C +ATOM 1990 C6 G B 62 6.956 -9.636 1.017 1.00 1.00 C +ATOM 1991 O6 G B 62 7.844 -10.148 0.339 1.00 1.00 O +ATOM 1992 N1 G B 62 5.708 -9.391 0.459 1.00 1.00 N +ATOM 1993 C2 G B 62 4.643 -8.822 1.124 1.00 1.00 C +ATOM 1994 N2 G B 62 3.522 -8.666 0.420 1.00 1.00 N +ATOM 1995 N3 G B 62 4.690 -8.436 2.404 1.00 1.00 N +ATOM 1996 C4 G B 62 5.900 -8.668 2.964 1.00 1.00 C +ATOM 1997 H5' G B 62 7.485 -5.770 8.079 1.00 1.00 H +ATOM 1998 H5'' G B 62 6.898 -6.872 9.340 1.00 1.00 H +ATOM 1999 H4' G B 62 5.125 -6.416 7.728 1.00 1.00 H +ATOM 2000 H3' G B 62 6.256 -9.217 7.691 1.00 1.00 H +ATOM 2001 H2' G B 62 4.917 -9.784 5.884 1.00 1.00 H +ATOM 2002 HO2' G B 62 3.001 -8.291 5.457 1.00 1.00 H +ATOM 2003 H1' G B 62 4.616 -7.175 4.773 1.00 1.00 H +ATOM 2004 H8 G B 62 8.131 -8.681 5.304 1.00 1.00 H +ATOM 2005 H1 G B 62 5.594 -9.656 -0.509 1.00 1.00 H +ATOM 2006 H21 G B 62 3.489 -8.958 -0.545 1.00 1.00 H +ATOM 2007 H22 G B 62 2.707 -8.256 0.852 1.00 1.00 H +ATOM 2008 P G B 63 4.370 -9.959 9.520 1.00 1.00 P +ATOM 2009 OP1 G B 63 3.705 -9.620 10.797 1.00 1.00 O +ATOM 2010 OP2 G B 63 5.691 -10.628 9.530 1.00 1.00 O +ATOM 2011 O5' G B 63 3.356 -10.855 8.649 1.00 1.00 O +ATOM 2012 C5' G B 63 3.499 -12.275 8.616 1.00 1.00 C +ATOM 2013 C4' G B 63 3.001 -12.855 7.295 1.00 1.00 C +ATOM 2014 O4' G B 63 3.423 -12.022 6.212 1.00 1.00 O +ATOM 2015 C3' G B 63 3.508 -14.262 7.014 1.00 1.00 C +ATOM 2016 O3' G B 63 2.512 -15.213 7.405 1.00 1.00 O +ATOM 2017 C2' G B 63 3.682 -14.291 5.504 1.00 1.00 C +ATOM 2018 O2' G B 63 2.501 -14.778 4.857 1.00 1.00 O +ATOM 2019 C1' G B 63 3.946 -12.830 5.149 1.00 1.00 C +ATOM 2020 N9 G B 63 5.375 -12.494 5.010 1.00 1.00 N +ATOM 2021 C8 G B 63 6.273 -12.172 5.994 1.00 1.00 C +ATOM 2022 N7 G B 63 7.474 -11.921 5.554 1.00 1.00 N +ATOM 2023 C5 G B 63 7.368 -12.087 4.177 1.00 1.00 C +ATOM 2024 C6 G B 63 8.357 -11.946 3.164 1.00 1.00 C +ATOM 2025 O6 G B 63 9.541 -11.644 3.292 1.00 1.00 O +ATOM 2026 N1 G B 63 7.835 -12.202 1.905 1.00 1.00 N +ATOM 2027 C2 G B 63 6.527 -12.550 1.645 1.00 1.00 C +ATOM 2028 N2 G B 63 6.217 -12.755 0.365 1.00 1.00 N +ATOM 2029 N3 G B 63 5.594 -12.684 2.594 1.00 1.00 N +ATOM 2030 C4 G B 63 6.085 -12.439 3.832 1.00 1.00 C +ATOM 2031 H5' G B 63 2.923 -12.708 9.434 1.00 1.00 H +ATOM 2032 H5'' G B 63 4.549 -12.531 8.748 1.00 1.00 H +ATOM 2033 H4' G B 63 1.913 -12.871 7.311 1.00 1.00 H +ATOM 2034 H3' G B 63 4.456 -14.446 7.518 1.00 1.00 H +ATOM 2035 H2' G B 63 4.548 -14.902 5.240 1.00 1.00 H +ATOM 2036 HO2' G B 63 1.881 -15.031 5.546 1.00 1.00 H +ATOM 2037 H1' G B 63 3.429 -12.585 4.222 1.00 1.00 H +ATOM 2038 H8 G B 63 6.008 -12.128 7.050 1.00 1.00 H +ATOM 2039 H1 G B 63 8.480 -12.121 1.132 1.00 1.00 H +ATOM 2040 H21 G B 63 6.924 -12.652 -0.348 1.00 1.00 H +ATOM 2041 H22 G B 63 5.277 -13.011 0.110 1.00 1.00 H +ATOM 2042 P A B 64 2.898 -16.460 8.348 1.00 1.00 P +ATOM 2043 OP1 A B 64 1.644 -17.118 8.779 1.00 1.00 O +ATOM 2044 OP2 A B 64 3.873 -15.993 9.359 1.00 1.00 O +ATOM 2045 O5' A B 64 3.660 -17.449 7.332 1.00 1.00 O +ATOM 2046 C5' A B 64 4.635 -18.376 7.814 1.00 1.00 C +ATOM 2047 C4' A B 64 4.992 -19.416 6.754 1.00 1.00 C +ATOM 2048 O4' A B 64 3.853 -20.246 6.494 1.00 1.00 O +ATOM 2049 C3' A B 64 5.434 -18.807 5.427 1.00 1.00 C +ATOM 2050 O3' A B 64 6.858 -18.891 5.314 1.00 1.00 O +ATOM 2051 C2' A B 64 4.785 -19.689 4.369 1.00 1.00 C +ATOM 2052 O2' A B 64 5.681 -20.713 3.923 1.00 1.00 O +ATOM 2053 C1' A B 64 3.579 -20.277 5.087 1.00 1.00 C +ATOM 2054 N9 A B 64 2.327 -19.530 4.862 1.00 1.00 N +ATOM 2055 C8 A B 64 1.729 -18.602 5.675 1.00 1.00 C +ATOM 2056 N7 A B 64 0.622 -18.112 5.193 1.00 1.00 N +ATOM 2057 C5 A B 64 0.473 -18.762 3.972 1.00 1.00 C +ATOM 2058 C6 A B 64 -0.507 -18.683 2.969 1.00 1.00 C +ATOM 2059 N6 A B 64 -1.566 -17.877 3.047 1.00 1.00 N +ATOM 2060 N1 A B 64 -0.348 -19.467 1.889 1.00 1.00 N +ATOM 2061 C2 A B 64 0.711 -20.265 1.819 1.00 1.00 C +ATOM 2062 N3 A B 64 1.696 -20.427 2.690 1.00 1.00 N +ATOM 2063 C4 A B 64 1.508 -19.629 3.762 1.00 1.00 C +ATOM 2064 H5' A B 64 4.240 -18.885 8.694 1.00 1.00 H +ATOM 2065 H5'' A B 64 5.536 -17.830 8.093 1.00 1.00 H +ATOM 2066 H4' A B 64 5.796 -20.042 7.136 1.00 1.00 H +ATOM 2067 H3' A B 64 5.090 -17.775 5.338 1.00 1.00 H +ATOM 2068 H2' A B 64 4.452 -19.077 3.528 1.00 1.00 H +ATOM 2069 HO2' A B 64 6.050 -20.425 3.086 1.00 1.00 H +ATOM 2070 H1' A B 64 3.441 -21.310 4.769 1.00 1.00 H +ATOM 2071 H8 A B 64 2.142 -18.303 6.638 1.00 1.00 H +ATOM 2072 H61 A B 64 -2.243 -17.859 2.297 1.00 1.00 H +ATOM 2073 H62 A B 64 -1.693 -17.285 3.856 1.00 1.00 H +ATOM 2074 H2 A B 64 0.777 -20.873 0.916 1.00 1.00 H +ATOM 2075 P A B 65 7.674 -17.798 4.460 1.00 1.00 P +ATOM 2076 OP1 A B 65 9.046 -17.714 5.009 1.00 1.00 O +ATOM 2077 OP2 A B 65 6.844 -16.577 4.355 1.00 1.00 O +ATOM 2078 O5' A B 65 7.756 -18.479 3.005 1.00 1.00 O +ATOM 2079 C5' A B 65 7.325 -17.760 1.847 1.00 1.00 C +ATOM 2080 C4' A B 65 6.427 -18.617 0.963 1.00 1.00 C +ATOM 2081 O4' A B 65 5.238 -18.956 1.682 1.00 1.00 O +ATOM 2082 C3' A B 65 6.002 -17.930 -0.332 1.00 1.00 C +ATOM 2083 O3' A B 65 6.836 -18.376 -1.409 1.00 1.00 O +ATOM 2084 C2' A B 65 4.576 -18.410 -0.549 1.00 1.00 C +ATOM 2085 O2' A B 65 4.537 -19.577 -1.377 1.00 1.00 O +ATOM 2086 C1' A B 65 4.088 -18.713 0.865 1.00 1.00 C +ATOM 2087 N9 A B 65 3.328 -17.611 1.483 1.00 1.00 N +ATOM 2088 C8 A B 65 3.693 -16.784 2.515 1.00 1.00 C +ATOM 2089 N7 A B 65 2.794 -15.886 2.814 1.00 1.00 N +ATOM 2090 C5 A B 65 1.761 -16.140 1.915 1.00 1.00 C +ATOM 2091 C6 A B 65 0.510 -15.534 1.708 1.00 1.00 C +ATOM 2092 N6 A B 65 0.070 -14.501 2.426 1.00 1.00 N +ATOM 2093 N1 A B 65 -0.264 -16.037 0.731 1.00 1.00 N +ATOM 2094 C2 A B 65 0.179 -17.065 0.018 1.00 1.00 C +ATOM 2095 N3 A B 65 1.326 -17.716 0.115 1.00 1.00 N +ATOM 2096 C4 A B 65 2.080 -17.189 1.103 1.00 1.00 C +ATOM 2097 H5' A B 65 8.199 -17.450 1.274 1.00 1.00 H +ATOM 2098 H5'' A B 65 6.774 -16.875 2.164 1.00 1.00 H +ATOM 2099 H4' A B 65 6.953 -19.538 0.715 1.00 1.00 H +ATOM 2100 H3' A B 65 6.036 -16.844 -0.226 1.00 1.00 H +ATOM 2101 H2' A B 65 3.976 -17.607 -0.985 1.00 1.00 H +ATOM 2102 HO2' A B 65 5.429 -19.931 -1.414 1.00 1.00 H +ATOM 2103 H1' A B 65 3.465 -19.607 0.848 1.00 1.00 H +ATOM 2104 H8 A B 65 4.647 -16.867 3.037 1.00 1.00 H +ATOM 2105 H61 A B 65 -0.836 -14.102 2.237 1.00 1.00 H +ATOM 2106 H62 A B 65 0.647 -14.118 3.162 1.00 1.00 H +ATOM 2107 H2 A B 65 -0.499 -17.425 -0.758 1.00 1.00 H +ATOM 2108 P A B 66 7.516 -17.317 -2.417 1.00 1.00 P +ATOM 2109 OP1 A B 66 8.396 -18.063 -3.344 1.00 1.00 O +ATOM 2110 OP2 A B 66 8.069 -16.204 -1.613 1.00 1.00 O +ATOM 2111 O5' A B 66 6.262 -16.756 -3.257 1.00 1.00 O +ATOM 2112 C5' A B 66 5.807 -17.440 -4.430 1.00 1.00 C +ATOM 2113 C4' A B 66 4.379 -17.041 -4.792 1.00 1.00 C +ATOM 2114 O4' A B 66 3.544 -17.158 -3.640 1.00 1.00 O +ATOM 2115 C3' A B 66 4.244 -15.613 -5.308 1.00 1.00 C +ATOM 2116 O3' A B 66 4.237 -15.619 -6.740 1.00 1.00 O +ATOM 2117 C2' A B 66 2.887 -15.167 -4.790 1.00 1.00 C +ATOM 2118 O2' A B 66 1.854 -15.418 -5.748 1.00 1.00 O +ATOM 2119 C1' A B 66 2.697 -16.007 -3.533 1.00 1.00 C +ATOM 2120 N9 A B 66 3.058 -15.303 -2.292 1.00 1.00 N +ATOM 2121 C8 A B 66 4.296 -15.143 -1.725 1.00 1.00 C +ATOM 2122 N7 A B 66 4.286 -14.442 -0.626 1.00 1.00 N +ATOM 2123 C5 A B 66 2.944 -14.115 -0.453 1.00 1.00 C +ATOM 2124 C6 A B 66 2.266 -13.379 0.533 1.00 1.00 C +ATOM 2125 N6 A B 66 2.878 -12.809 1.571 1.00 1.00 N +ATOM 2126 N1 A B 66 0.936 -13.253 0.400 1.00 1.00 N +ATOM 2127 C2 A B 66 0.333 -13.818 -0.638 1.00 1.00 C +ATOM 2128 N3 A B 66 0.856 -14.528 -1.626 1.00 1.00 N +ATOM 2129 C4 A B 66 2.190 -14.638 -1.463 1.00 1.00 C +ATOM 2130 H5' A B 66 5.845 -18.515 -4.253 1.00 1.00 H +ATOM 2131 H5'' A B 66 6.466 -17.192 -5.262 1.00 1.00 H +ATOM 2132 H4' A B 66 4.008 -17.725 -5.553 1.00 1.00 H +ATOM 2133 H3' A B 66 5.040 -14.979 -4.915 1.00 1.00 H +ATOM 2134 H2' A B 66 2.918 -14.108 -4.525 1.00 1.00 H +ATOM 2135 HO2' A B 66 1.664 -16.359 -5.724 1.00 1.00 H +ATOM 2136 H1' A B 66 1.659 -16.328 -3.469 1.00 1.00 H +ATOM 2137 H8 A B 66 5.207 -15.563 -2.153 1.00 1.00 H +ATOM 2138 H61 A B 66 2.342 -12.289 2.251 1.00 1.00 H +ATOM 2139 H62 A B 66 3.884 -12.898 1.681 1.00 1.00 H +ATOM 2140 H2 A B 66 -0.747 -13.675 -0.685 1.00 1.00 H +ATOM 2141 P C B 67 5.055 -14.508 -7.572 1.00 1.00 P +ATOM 2142 OP1 C B 67 4.886 -14.797 -9.014 1.00 1.00 O +ATOM 2143 OP2 C B 67 6.413 -14.403 -6.994 1.00 1.00 O +ATOM 2144 O5' C B 67 4.256 -13.151 -7.234 1.00 1.00 O +ATOM 2145 C5' C B 67 2.861 -13.040 -7.526 1.00 1.00 C +ATOM 2146 C4' C B 67 2.185 -11.997 -6.640 1.00 1.00 C +ATOM 2147 O4' C B 67 2.326 -12.368 -5.266 1.00 1.00 O +ATOM 2148 C3' C B 67 2.756 -10.592 -6.776 1.00 1.00 C +ATOM 2149 O3' C B 67 2.001 -9.850 -7.737 1.00 1.00 O +ATOM 2150 C2' C B 67 2.552 -9.991 -5.398 1.00 1.00 C +ATOM 2151 O2' C B 67 1.288 -9.326 -5.299 1.00 1.00 O +ATOM 2152 C1' C B 67 2.618 -11.203 -4.480 1.00 1.00 C +ATOM 2153 N1 C B 67 3.941 -11.402 -3.863 1.00 1.00 N +ATOM 2154 C2 C B 67 4.187 -10.757 -2.661 1.00 1.00 C +ATOM 2155 O2 C B 67 3.320 -10.053 -2.150 1.00 1.00 O +ATOM 2156 N3 C B 67 5.406 -10.927 -2.075 1.00 1.00 N +ATOM 2157 C4 C B 67 6.342 -11.698 -2.645 1.00 1.00 C +ATOM 2158 N4 C B 67 7.524 -11.842 -2.046 1.00 1.00 N +ATOM 2159 C5 C B 67 6.091 -12.364 -3.886 1.00 1.00 C +ATOM 2160 C6 C B 67 4.882 -12.191 -4.457 1.00 1.00 C +ATOM 2161 H5' C B 67 2.385 -14.008 -7.365 1.00 1.00 H +ATOM 2162 H5'' C B 67 2.737 -12.752 -8.570 1.00 1.00 H +ATOM 2163 H4' C B 67 1.123 -11.968 -6.879 1.00 1.00 H +ATOM 2164 H3' C B 67 3.815 -10.624 -7.038 1.00 1.00 H +ATOM 2165 H2' C B 67 3.369 -9.306 -5.165 1.00 1.00 H +ATOM 2166 HO2' C B 67 0.975 -9.443 -4.399 1.00 1.00 H +ATOM 2167 H1' C B 67 1.867 -11.102 -3.698 1.00 1.00 H +ATOM 2168 H41 C B 67 7.706 -11.375 -1.170 1.00 1.00 H +ATOM 2169 H42 C B 67 8.236 -12.421 -2.467 1.00 1.00 H +ATOM 2170 H5 C B 67 6.851 -12.991 -4.354 1.00 1.00 H +ATOM 2171 H6 C B 67 4.656 -12.684 -5.402 1.00 1.00 H +ATOM 2172 P U B 68 2.629 -8.544 -8.438 1.00 1.00 P +ATOM 2173 OP1 U B 68 1.639 -8.013 -9.401 1.00 1.00 O +ATOM 2174 OP2 U B 68 3.998 -8.875 -8.893 1.00 1.00 O +ATOM 2175 O5' U B 68 2.743 -7.506 -7.210 1.00 1.00 O +ATOM 2176 C5' U B 68 1.570 -7.030 -6.544 1.00 1.00 C +ATOM 2177 C4' U B 68 1.923 -6.210 -5.304 1.00 1.00 C +ATOM 2178 O4' U B 68 2.696 -6.994 -4.399 1.00 1.00 O +ATOM 2179 C3' U B 68 2.739 -4.961 -5.592 1.00 1.00 C +ATOM 2180 O3' U B 68 1.864 -3.857 -5.854 1.00 1.00 O +ATOM 2181 C2' U B 68 3.498 -4.734 -4.297 1.00 1.00 C +ATOM 2182 O2' U B 68 2.785 -3.851 -3.425 1.00 1.00 O +ATOM 2183 C1' U B 68 3.618 -6.140 -3.701 1.00 1.00 C +ATOM 2184 N1 U B 68 4.965 -6.737 -3.841 1.00 1.00 N +ATOM 2185 C2 U B 68 5.846 -6.592 -2.786 1.00 1.00 C +ATOM 2186 O2 U B 68 5.546 -5.983 -1.761 1.00 1.00 O +ATOM 2187 N3 U B 68 7.093 -7.170 -2.952 1.00 1.00 N +ATOM 2188 C4 U B 68 7.526 -7.871 -4.064 1.00 1.00 C +ATOM 2189 O4 U B 68 8.661 -8.344 -4.104 1.00 1.00 O +ATOM 2190 C5 U B 68 6.541 -7.974 -5.117 1.00 1.00 C +ATOM 2191 C6 U B 68 5.313 -7.417 -4.977 1.00 1.00 C +ATOM 2192 H5' U B 68 0.961 -7.884 -6.244 1.00 1.00 H +ATOM 2193 H5'' U B 68 0.997 -6.409 -7.231 1.00 1.00 H +ATOM 2194 H4' U B 68 1.001 -5.920 -4.803 1.00 1.00 H +ATOM 2195 H3' U B 68 3.426 -5.129 -6.422 1.00 1.00 H +ATOM 2196 H2' U B 68 4.489 -4.339 -4.515 1.00 1.00 H +ATOM 2197 HO2' U B 68 2.519 -4.362 -2.657 1.00 1.00 H +ATOM 2198 H1' U B 68 3.343 -6.105 -2.647 1.00 1.00 H +ATOM 2199 H3 U B 68 7.748 -7.071 -2.190 1.00 1.00 H +ATOM 2200 H5 U B 68 6.787 -8.508 -6.034 1.00 1.00 H +ATOM 2201 H6 U B 68 4.589 -7.508 -5.786 1.00 1.00 H +ATOM 2202 P U B 69 2.401 -2.547 -6.628 1.00 1.00 P +ATOM 2203 OP1 U B 69 1.231 -1.743 -7.044 1.00 1.00 O +ATOM 2204 OP2 U B 69 3.394 -2.982 -7.637 1.00 1.00 O +ATOM 2205 O5' U B 69 3.181 -1.737 -5.473 1.00 1.00 O +ATOM 2206 C5' U B 69 2.471 -1.210 -4.348 1.00 1.00 C +ATOM 2207 C4' U B 69 3.405 -0.926 -3.173 1.00 1.00 C +ATOM 2208 O4' U B 69 4.171 -2.089 -2.869 1.00 1.00 O +ATOM 2209 C3' U B 69 4.415 0.183 -3.414 1.00 1.00 C +ATOM 2210 O3' U B 69 3.846 1.458 -3.070 1.00 1.00 O +ATOM 2211 C2' U B 69 5.542 -0.173 -2.452 1.00 1.00 C +ATOM 2212 O2' U B 69 5.372 0.460 -1.184 1.00 1.00 O +ATOM 2213 C1' U B 69 5.439 -1.690 -2.322 1.00 1.00 C +ATOM 2214 N1 U B 69 6.492 -2.415 -3.064 1.00 1.00 N +ATOM 2215 C2 U B 69 7.604 -2.843 -2.362 1.00 1.00 C +ATOM 2216 O2 U B 69 7.736 -2.637 -1.157 1.00 1.00 O +ATOM 2217 N3 U B 69 8.564 -3.515 -3.098 1.00 1.00 N +ATOM 2218 C4 U B 69 8.509 -3.793 -4.453 1.00 1.00 C +ATOM 2219 O4 U B 69 9.423 -4.400 -5.006 1.00 1.00 O +ATOM 2220 C5 U B 69 7.311 -3.309 -5.104 1.00 1.00 C +ATOM 2221 C6 U B 69 6.357 -2.648 -4.404 1.00 1.00 C +ATOM 2222 H5' U B 69 1.716 -1.932 -4.035 1.00 1.00 H +ATOM 2223 H5'' U B 69 1.976 -0.285 -4.641 1.00 1.00 H +ATOM 2224 H4' U B 69 2.806 -0.674 -2.300 1.00 1.00 H +ATOM 2225 H3' U B 69 4.769 0.170 -4.448 1.00 1.00 H +ATOM 2226 H2' U B 69 6.501 0.092 -2.892 1.00 1.00 H +ATOM 2227 HO2' U B 69 4.846 -0.128 -0.637 1.00 1.00 H +ATOM 2228 H1' U B 69 5.479 -1.965 -1.267 1.00 1.00 H +ATOM 2229 H3 U B 69 9.383 -3.833 -2.598 1.00 1.00 H +ATOM 2230 H5 U B 69 7.176 -3.476 -6.172 1.00 1.00 H +ATOM 2231 H6 U B 69 5.463 -2.297 -4.920 1.00 1.00 H +ATOM 2232 P G B 70 4.501 2.838 -3.609 1.00 1.00 P +ATOM 2233 OP1 G B 70 3.599 3.953 -3.243 1.00 1.00 O +ATOM 2234 OP2 G B 70 4.900 2.641 -5.021 1.00 1.00 O +ATOM 2235 O5' G B 70 5.833 2.953 -2.715 1.00 1.00 O +ATOM 2236 C5' G B 70 5.728 2.908 -1.293 1.00 1.00 C +ATOM 2237 C4' G B 70 7.039 2.482 -0.643 1.00 1.00 C +ATOM 2238 O4' G B 70 7.536 1.317 -1.301 1.00 1.00 O +ATOM 2239 C3' G B 70 8.158 3.507 -0.716 1.00 1.00 C +ATOM 2240 O3' G B 70 8.108 4.347 0.444 1.00 1.00 O +ATOM 2241 C2' G B 70 9.415 2.651 -0.661 1.00 1.00 C +ATOM 2242 O2' G B 70 9.944 2.584 0.665 1.00 1.00 O +ATOM 2243 C1' G B 70 8.957 1.276 -1.142 1.00 1.00 C +ATOM 2244 N9 G B 70 9.598 0.836 -2.396 1.00 1.00 N +ATOM 2245 C8 G B 70 9.120 0.826 -3.682 1.00 1.00 C +ATOM 2246 N7 G B 70 9.946 0.306 -4.548 1.00 1.00 N +ATOM 2247 C5 G B 70 11.051 -0.053 -3.782 1.00 1.00 C +ATOM 2248 C6 G B 70 12.274 -0.665 -4.175 1.00 1.00 C +ATOM 2249 O6 G B 70 12.620 -1.024 -5.299 1.00 1.00 O +ATOM 2250 N1 G B 70 13.122 -0.848 -3.092 1.00 1.00 N +ATOM 2251 C2 G B 70 12.833 -0.490 -1.792 1.00 1.00 C +ATOM 2252 N2 G B 70 13.776 -0.739 -0.885 1.00 1.00 N +ATOM 2253 N3 G B 70 11.686 0.084 -1.422 1.00 1.00 N +ATOM 2254 C4 G B 70 10.847 0.272 -2.466 1.00 1.00 C +ATOM 2255 H5' G B 70 4.949 2.196 -1.017 1.00 1.00 H +ATOM 2256 H5'' G B 70 5.450 3.896 -0.924 1.00 1.00 H +ATOM 2257 H4' G B 70 6.852 2.232 0.400 1.00 1.00 H +ATOM 2258 H3' G B 70 8.112 4.084 -1.640 1.00 1.00 H +ATOM 2259 H2' G B 70 10.163 3.050 -1.349 1.00 1.00 H +ATOM 2260 HO2' G B 70 9.207 2.432 1.259 1.00 1.00 H +ATOM 2261 H1' G B 70 9.189 0.541 -0.372 1.00 1.00 H +ATOM 2262 H8 G B 70 8.143 1.221 -3.957 1.00 1.00 H +ATOM 2263 H1 G B 70 14.011 -1.283 -3.292 1.00 1.00 H +ATOM 2264 H21 G B 70 14.650 -1.172 -1.166 1.00 1.00 H +ATOM 2265 H22 G B 70 13.621 -0.498 0.084 1.00 1.00 H +ATOM 2266 P G B 71 9.048 5.650 0.566 1.00 1.00 P +ATOM 2267 OP1 G B 71 8.431 6.566 1.551 1.00 1.00 O +ATOM 2268 OP2 G B 71 9.352 6.134 -0.800 1.00 1.00 O +ATOM 2269 O5' G B 71 10.411 5.064 1.209 1.00 1.00 O +ATOM 2270 C5' G B 71 10.487 4.708 2.597 1.00 1.00 C +ATOM 2271 C4' G B 71 11.938 4.672 3.089 1.00 1.00 C +ATOM 2272 O4' G B 71 12.518 3.383 2.857 1.00 1.00 O +ATOM 2273 C3' G B 71 12.833 5.702 2.411 1.00 1.00 C +ATOM 2274 O3' G B 71 12.936 6.864 3.239 1.00 1.00 O +ATOM 2275 C2' G B 71 14.180 5.006 2.313 1.00 1.00 C +ATOM 2276 O2' G B 71 14.995 5.262 3.463 1.00 1.00 O +ATOM 2277 C1' G B 71 13.794 3.538 2.219 1.00 1.00 C +ATOM 2278 N9 G B 71 13.636 3.057 0.844 1.00 1.00 N +ATOM 2279 C8 G B 71 12.479 2.680 0.214 1.00 1.00 C +ATOM 2280 N7 G B 71 12.647 2.314 -1.026 1.00 1.00 N +ATOM 2281 C5 G B 71 14.013 2.456 -1.236 1.00 1.00 C +ATOM 2282 C6 G B 71 14.784 2.205 -2.404 1.00 1.00 C +ATOM 2283 O6 G B 71 14.399 1.801 -3.499 1.00 1.00 O +ATOM 2284 N1 G B 71 16.128 2.476 -2.195 1.00 1.00 N +ATOM 2285 C2 G B 71 16.669 2.932 -1.012 1.00 1.00 C +ATOM 2286 N2 G B 71 17.986 3.136 -1.008 1.00 1.00 N +ATOM 2287 N3 G B 71 15.947 3.171 0.089 1.00 1.00 N +ATOM 2288 C4 G B 71 14.630 2.912 -0.096 1.00 1.00 C +ATOM 2289 H5' G B 71 10.035 3.724 2.740 1.00 1.00 H +ATOM 2290 H5'' G B 71 9.931 5.442 3.183 1.00 1.00 H +ATOM 2291 H4' G B 71 11.945 4.862 4.162 1.00 1.00 H +ATOM 2292 H3' G B 71 12.454 5.955 1.419 1.00 1.00 H +ATOM 2293 H2' G B 71 14.694 5.310 1.399 1.00 1.00 H +ATOM 2294 HO2' G B 71 14.489 5.825 4.053 1.00 1.00 H +ATOM 2295 H1' G B 71 14.539 2.930 2.731 1.00 1.00 H +ATOM 2296 H8 G B 71 11.506 2.681 0.705 1.00 1.00 H +ATOM 2297 H1 G B 71 16.740 2.320 -2.982 1.00 1.00 H +ATOM 2298 H21 G B 71 18.527 2.953 -1.843 1.00 1.00 H +ATOM 2299 H22 G B 71 18.443 3.469 -0.171 1.00 1.00 H +ATOM 2300 P U B 72 12.983 8.332 2.580 1.00 1.00 P +ATOM 2301 OP1 U B 72 12.863 9.330 3.667 1.00 1.00 O +ATOM 2302 OP2 U B 72 12.032 8.360 1.445 1.00 1.00 O +ATOM 2303 O5' U B 72 14.477 8.411 1.985 1.00 1.00 O +ATOM 2304 C5' U B 72 15.608 8.487 2.858 1.00 1.00 C +ATOM 2305 C4' U B 72 16.916 8.543 2.072 1.00 1.00 C +ATOM 2306 O4' U B 72 17.146 7.299 1.414 1.00 1.00 O +ATOM 2307 C3' U B 72 16.941 9.616 0.996 1.00 1.00 C +ATOM 2308 O3' U B 72 17.446 10.843 1.536 1.00 1.00 O +ATOM 2309 C2' U B 72 17.903 9.050 -0.033 1.00 1.00 C +ATOM 2310 O2' U B 72 19.251 9.458 0.225 1.00 1.00 O +ATOM 2311 C1' U B 72 17.733 7.542 0.125 1.00 1.00 C +ATOM 2312 N1 U B 72 16.839 6.937 -0.882 1.00 1.00 N +ATOM 2313 C2 U B 72 17.408 6.462 -2.048 1.00 1.00 C +ATOM 2314 O2 U B 72 18.615 6.546 -2.268 1.00 1.00 O +ATOM 2315 N3 U B 72 16.540 5.883 -2.956 1.00 1.00 N +ATOM 2316 C4 U B 72 15.171 5.741 -2.802 1.00 1.00 C +ATOM 2317 O4 U B 72 14.494 5.210 -3.679 1.00 1.00 O +ATOM 2318 C5 U B 72 14.663 6.266 -1.554 1.00 1.00 C +ATOM 2319 C6 U B 72 15.493 6.838 -0.650 1.00 1.00 C +ATOM 2320 H5' U B 72 15.619 7.608 3.505 1.00 1.00 H +ATOM 2321 H5'' U B 72 15.524 9.382 3.473 1.00 1.00 H +ATOM 2322 H4' U B 72 17.735 8.722 2.766 1.00 1.00 H +ATOM 2323 H3' U B 72 15.949 9.753 0.561 1.00 1.00 H +ATOM 2324 H2' U B 72 17.593 9.349 -1.031 1.00 1.00 H +ATOM 2325 HO2' U B 72 19.828 8.789 -0.151 1.00 1.00 H +ATOM 2326 H1' U B 72 18.710 7.061 0.080 1.00 1.00 H +ATOM 2327 H3 U B 72 16.942 5.531 -3.813 1.00 1.00 H +ATOM 2328 H5 U B 72 13.596 6.203 -1.340 1.00 1.00 H +ATOM 2329 H6 U B 72 15.083 7.226 0.282 1.00 1.00 H +ATOM 2330 P U B 73 17.021 12.260 0.891 1.00 1.00 P +ATOM 2331 OP1 U B 73 17.502 13.339 1.781 1.00 1.00 O +ATOM 2332 OP2 U B 73 15.587 12.188 0.527 1.00 1.00 O +ATOM 2333 O5' U B 73 17.880 12.312 -0.472 1.00 1.00 O +ATOM 2334 C5' U B 73 19.268 12.663 -0.449 1.00 1.00 C +ATOM 2335 C4' U B 73 19.903 12.532 -1.833 1.00 1.00 C +ATOM 2336 O4' U B 73 19.735 11.202 -2.321 1.00 1.00 O +ATOM 2337 C3' U B 73 19.310 13.452 -2.890 1.00 1.00 C +ATOM 2338 O3' U B 73 19.994 14.711 -2.892 1.00 1.00 O +ATOM 2339 C2' U B 73 19.592 12.702 -4.182 1.00 1.00 C +ATOM 2340 O2' U B 73 20.869 13.056 -4.722 1.00 1.00 O +ATOM 2341 C1' U B 73 19.547 11.240 -3.745 1.00 1.00 C +ATOM 2342 N1 U B 73 18.260 10.578 -4.037 1.00 1.00 N +ATOM 2343 C2 U B 73 18.170 9.840 -5.201 1.00 1.00 C +ATOM 2344 O2 U B 73 19.103 9.755 -5.997 1.00 1.00 O +ATOM 2345 N3 U B 73 16.962 9.203 -5.423 1.00 1.00 N +ATOM 2346 C4 U B 73 15.854 9.239 -4.593 1.00 1.00 C +ATOM 2347 O4 U B 73 14.829 8.629 -4.890 1.00 1.00 O +ATOM 2348 C5 U B 73 16.039 10.035 -3.401 1.00 1.00 C +ATOM 2349 C6 U B 73 17.212 10.668 -3.162 1.00 1.00 C +ATOM 2350 H5' U B 73 19.791 12.006 0.248 1.00 1.00 H +ATOM 2351 H5'' U B 73 19.367 13.694 -0.109 1.00 1.00 H +ATOM 2352 H4' U B 73 20.970 12.734 -1.749 1.00 1.00 H +ATOM 2353 H3' U B 73 18.236 13.579 -2.739 1.00 1.00 H +ATOM 2354 H2' U B 73 18.801 12.893 -4.904 1.00 1.00 H +ATOM 2355 HO2' U B 73 21.332 12.240 -4.920 1.00 1.00 H +ATOM 2356 H1' U B 73 20.355 10.687 -4.227 1.00 1.00 H +ATOM 2357 H3 U B 73 16.881 8.659 -6.271 1.00 1.00 H +ATOM 2358 H5 U B 73 15.223 10.126 -2.684 1.00 1.00 H +ATOM 2359 H6 U B 73 17.323 11.263 -2.255 1.00 1.00 H +ATOM 2360 P C B 74 19.239 16.058 -3.361 1.00 1.00 P +ATOM 2361 OP1 C B 74 20.206 17.177 -3.292 1.00 1.00 O +ATOM 2362 OP2 C B 74 17.956 16.147 -2.629 1.00 1.00 O +ATOM 2363 O5' C B 74 18.913 15.776 -4.915 1.00 1.00 O +ATOM 2364 C5' C B 74 19.959 15.745 -5.890 1.00 1.00 C +ATOM 2365 C4' C B 74 19.460 15.206 -7.229 1.00 1.00 C +ATOM 2366 O4' C B 74 19.043 13.858 -7.084 1.00 1.00 O +ATOM 2367 C3' C B 74 18.265 15.945 -7.801 1.00 1.00 C +ATOM 2368 O3' C B 74 18.709 17.086 -8.547 1.00 1.00 O +ATOM 2369 C2' C B 74 17.660 14.900 -8.735 1.00 1.00 C +ATOM 2370 O2' C B 74 18.198 14.999 -10.057 1.00 1.00 O +ATOM 2371 C1' C B 74 18.038 13.572 -8.069 1.00 1.00 C +ATOM 2372 N1 C B 74 16.915 12.920 -7.363 1.00 1.00 N +ATOM 2373 C2 C B 74 16.254 11.890 -8.013 1.00 1.00 C +ATOM 2374 O2 C B 74 16.601 11.554 -9.144 1.00 1.00 O +ATOM 2375 N3 C B 74 15.224 11.275 -7.369 1.00 1.00 N +ATOM 2376 C4 C B 74 14.857 11.656 -6.137 1.00 1.00 C +ATOM 2377 N4 C B 74 13.843 11.032 -5.534 1.00 1.00 N +ATOM 2378 C5 C B 74 15.535 12.720 -5.463 1.00 1.00 C +ATOM 2379 C6 C B 74 16.554 13.322 -6.109 1.00 1.00 C +ATOM 2380 H5' C B 74 20.769 15.109 -5.528 1.00 1.00 H +ATOM 2381 H5'' C B 74 20.340 16.757 -6.034 1.00 1.00 H +ATOM 2382 H4' C B 74 20.275 15.235 -7.949 1.00 1.00 H +ATOM 2383 H3' C B 74 17.559 16.225 -7.014 1.00 1.00 H +ATOM 2384 H2' C B 74 16.581 15.001 -8.758 1.00 1.00 H +ATOM 2385 HO2' C B 74 17.463 15.181 -10.651 1.00 1.00 H +ATOM 2386 H1' C B 74 18.445 12.889 -8.817 1.00 1.00 H +ATOM 2387 H41 C B 74 13.363 10.282 -6.006 1.00 1.00 H +ATOM 2388 H42 C B 74 13.559 11.311 -4.607 1.00 1.00 H +ATOM 2389 H5 C B 74 15.240 13.032 -4.461 1.00 1.00 H +ATOM 2390 H6 C B 74 17.093 14.136 -5.626 1.00 1.00 H +ATOM 2391 P U B 75 18.078 18.547 -8.275 1.00 1.00 P +ATOM 2392 OP1 U B 75 19.059 19.556 -8.734 1.00 1.00 O +ATOM 2393 OP2 U B 75 17.591 18.582 -6.879 1.00 1.00 O +ATOM 2394 O5' U B 75 16.802 18.619 -9.258 1.00 1.00 O +ATOM 2395 C5' U B 75 16.932 18.291 -10.643 1.00 1.00 C +ATOM 2396 C4' U B 75 15.805 17.375 -11.124 1.00 1.00 C +ATOM 2397 O4' U B 75 15.742 16.194 -10.334 1.00 1.00 O +ATOM 2398 C3' U B 75 14.417 17.985 -11.054 1.00 1.00 C +ATOM 2399 O3' U B 75 14.157 18.729 -12.251 1.00 1.00 O +ATOM 2400 C2' U B 75 13.511 16.764 -10.996 1.00 1.00 C +ATOM 2401 O2' U B 75 13.004 16.424 -12.289 1.00 1.00 O +ATOM 2402 C1' U B 75 14.410 15.663 -10.435 1.00 1.00 C +ATOM 2403 N1 U B 75 13.988 15.162 -9.103 1.00 1.00 N +ATOM 2404 C2 U B 75 13.198 14.028 -9.083 1.00 1.00 C +ATOM 2405 O2 U B 75 12.845 13.459 -10.114 1.00 1.00 O +ATOM 2406 N3 U B 75 12.827 13.568 -7.833 1.00 1.00 N +ATOM 2407 C4 U B 75 13.171 14.137 -6.619 1.00 1.00 C +ATOM 2408 O4 U B 75 12.784 13.640 -5.563 1.00 1.00 O +ATOM 2409 C5 U B 75 13.997 15.319 -6.734 1.00 1.00 C +ATOM 2410 C6 U B 75 14.373 15.787 -7.949 1.00 1.00 C +ATOM 2411 H5' U B 75 17.888 17.791 -10.799 1.00 1.00 H +ATOM 2412 H5'' U B 75 16.915 19.212 -11.227 1.00 1.00 H +ATOM 2413 H4' U B 75 16.009 17.085 -12.153 1.00 1.00 H +ATOM 2414 H3' U B 75 14.304 18.604 -10.163 1.00 1.00 H +ATOM 2415 H2' U B 75 12.699 16.951 -10.300 1.00 1.00 H +ATOM 2416 HO2' U B 75 12.911 15.468 -12.316 1.00 1.00 H +ATOM 2417 H1' U B 75 14.420 14.831 -11.142 1.00 1.00 H +ATOM 2418 H3 U B 75 12.250 12.739 -7.803 1.00 1.00 H +ATOM 2419 H5 U B 75 14.320 15.838 -5.832 1.00 1.00 H +ATOM 2420 H6 U B 75 14.995 16.681 -8.007 1.00 1.00 H +ATOM 2421 P U B 76 12.988 19.838 -12.297 1.00 1.00 P +ATOM 2422 OP1 U B 76 13.165 20.640 -13.528 1.00 1.00 O +ATOM 2423 OP2 U B 76 12.935 20.509 -10.979 1.00 1.00 O +ATOM 2424 O5' U B 76 11.654 18.948 -12.463 1.00 1.00 O +ATOM 2425 C5' U B 76 11.305 18.396 -13.736 1.00 1.00 C +ATOM 2426 C4' U B 76 10.127 17.428 -13.629 1.00 1.00 C +ATOM 2427 O4' U B 76 10.400 16.449 -12.633 1.00 1.00 O +ATOM 2428 C3' U B 76 8.811 18.083 -13.241 1.00 1.00 C +ATOM 2429 O3' U B 76 8.076 18.427 -14.418 1.00 1.00 O +ATOM 2430 C2' U B 76 8.068 16.992 -12.481 1.00 1.00 C +ATOM 2431 O2' U B 76 7.141 16.306 -13.330 1.00 1.00 O +ATOM 2432 C1' U B 76 9.176 16.056 -11.997 1.00 1.00 C +ATOM 2433 N1 U B 76 9.398 16.107 -10.537 1.00 1.00 N +ATOM 2434 C2 U B 76 8.787 15.141 -9.759 1.00 1.00 C +ATOM 2435 O2 U B 76 8.079 14.262 -10.245 1.00 1.00 O +ATOM 2436 N3 U B 76 9.020 15.222 -8.398 1.00 1.00 N +ATOM 2437 C4 U B 76 9.800 16.170 -7.757 1.00 1.00 C +ATOM 2438 O4 U B 76 9.938 16.146 -6.536 1.00 1.00 O +ATOM 2439 C5 U B 76 10.399 17.138 -8.648 1.00 1.00 C +ATOM 2440 C6 U B 76 10.185 17.080 -9.984 1.00 1.00 C +ATOM 2441 H5' U B 76 12.167 17.864 -14.141 1.00 1.00 H +ATOM 2442 H5'' U B 76 11.038 19.206 -14.414 1.00 1.00 H +ATOM 2443 H4' U B 76 10.000 16.922 -14.584 1.00 1.00 H +ATOM 2444 H3' U B 76 8.980 18.955 -12.607 1.00 1.00 H +ATOM 2445 H2' U B 76 7.552 17.427 -11.621 1.00 1.00 H +ATOM 2446 HO2' U B 76 6.546 15.811 -12.761 1.00 1.00 H +ATOM 2447 H1' U B 76 8.934 15.034 -12.291 1.00 1.00 H +ATOM 2448 H3 U B 76 8.581 14.522 -7.817 1.00 1.00 H +ATOM 2449 H5 U B 76 11.032 17.926 -8.239 1.00 1.00 H +ATOM 2450 H6 U B 76 10.650 17.823 -10.632 1.00 1.00 H +ATOM 2451 P C B 77 6.769 19.359 -14.312 1.00 1.00 P +ATOM 2452 OP1 C B 77 6.221 19.546 -15.674 1.00 1.00 O +ATOM 2453 OP2 C B 77 7.105 20.536 -13.483 1.00 1.00 O +ATOM 2454 O5' C B 77 5.748 18.430 -13.481 1.00 1.00 O +ATOM 2455 C5' C B 77 5.070 18.944 -12.332 1.00 1.00 C +ATOM 2456 C4' C B 77 4.262 17.860 -11.622 1.00 1.00 C +ATOM 2457 O4' C B 77 5.133 17.027 -10.859 1.00 1.00 O +ATOM 2458 C3' C B 77 3.217 18.398 -10.660 1.00 1.00 C +ATOM 2459 O3' C B 77 1.964 18.526 -11.339 1.00 1.00 O +ATOM 2460 C2' C B 77 3.117 17.326 -9.585 1.00 1.00 C +ATOM 2461 O2' C B 77 2.032 16.429 -9.844 1.00 1.00 O +ATOM 2462 C1' C B 77 4.465 16.606 -9.660 1.00 1.00 C +ATOM 2463 N1 C B 77 5.364 16.904 -8.530 1.00 1.00 N +ATOM 2464 C2 C B 77 5.140 16.233 -7.339 1.00 1.00 C +ATOM 2465 O2 C B 77 4.215 15.428 -7.252 1.00 1.00 O +ATOM 2466 N3 C B 77 5.964 16.490 -6.288 1.00 1.00 N +ATOM 2467 C4 C B 77 6.967 17.371 -6.400 1.00 1.00 C +ATOM 2468 N4 C B 77 7.757 17.598 -5.351 1.00 1.00 N +ATOM 2469 C5 C B 77 7.202 18.068 -7.627 1.00 1.00 C +ATOM 2470 C6 C B 77 6.380 17.805 -8.662 1.00 1.00 C +ATOM 2471 H5' C B 77 4.396 19.742 -12.645 1.00 1.00 H +ATOM 2472 H5'' C B 77 5.805 19.350 -11.638 1.00 1.00 H +ATOM 2473 H4' C B 77 3.769 17.244 -12.371 1.00 1.00 H +ATOM 2474 H3' C B 77 3.535 19.349 -10.233 1.00 1.00 H +ATOM 2475 H2' C B 77 3.002 17.796 -8.604 1.00 1.00 H +ATOM 2476 HO2' C B 77 2.290 15.873 -10.583 1.00 1.00 H +ATOM 2477 H1' C B 77 4.294 15.531 -9.705 1.00 1.00 H +ATOM 2478 H41 C B 77 7.596 17.108 -4.481 1.00 1.00 H +ATOM 2479 H42 C B 77 8.518 18.260 -5.423 1.00 1.00 H +ATOM 2480 H5 C B 77 8.017 18.787 -7.721 1.00 1.00 H +ATOM 2481 H6 C B 77 6.530 18.317 -9.613 1.00 1.00 H +ATOM 2482 P C B 78 0.841 19.542 -10.795 1.00 1.00 P +ATOM 2483 OP1 C B 78 -0.356 19.410 -11.654 1.00 1.00 O +ATOM 2484 OP2 C B 78 1.470 20.867 -10.603 1.00 1.00 O +ATOM 2485 O5' C B 78 0.492 18.934 -9.347 1.00 1.00 O +ATOM 2486 C5' C B 78 0.174 19.801 -8.256 1.00 1.00 C +ATOM 2487 C4' C B 78 -0.521 19.049 -7.127 1.00 1.00 C +ATOM 2488 O4' C B 78 0.355 18.062 -6.591 1.00 1.00 O +ATOM 2489 C3' C B 78 -0.952 19.938 -5.973 1.00 1.00 C +ATOM 2490 O3' C B 78 -2.308 20.348 -6.171 1.00 1.00 O +ATOM 2491 C2' C B 78 -0.848 19.034 -4.754 1.00 1.00 C +ATOM 2492 O2' C B 78 -2.108 18.429 -4.445 1.00 1.00 O +ATOM 2493 C1' C B 78 0.187 17.987 -5.169 1.00 1.00 C +ATOM 2494 N1 C B 78 1.515 18.188 -4.563 1.00 1.00 N +ATOM 2495 C2 C B 78 1.708 17.700 -3.280 1.00 1.00 C +ATOM 2496 O2 C B 78 0.792 17.128 -2.695 1.00 1.00 O +ATOM 2497 N3 C B 78 2.928 17.876 -2.701 1.00 1.00 N +ATOM 2498 C4 C B 78 3.916 18.504 -3.353 1.00 1.00 C +ATOM 2499 N4 C B 78 5.097 18.660 -2.757 1.00 1.00 N +ATOM 2500 C5 C B 78 3.719 19.009 -4.677 1.00 1.00 C +ATOM 2501 C6 C B 78 2.509 18.830 -5.242 1.00 1.00 C +ATOM 2502 H5' C B 78 -0.480 20.596 -8.611 1.00 1.00 H +ATOM 2503 H5'' C B 78 1.095 20.241 -7.873 1.00 1.00 H +ATOM 2504 H4' C B 78 -1.398 18.546 -7.529 1.00 1.00 H +ATOM 2505 H3' C B 78 -0.288 20.798 -5.875 1.00 1.00 H +ATOM 2506 H2' C B 78 -0.475 19.603 -3.900 1.00 1.00 H +ATOM 2507 HO2' C B 78 -2.033 17.493 -4.645 1.00 1.00 H +ATOM 2508 H1' C B 78 -0.180 16.996 -4.901 1.00 1.00 H +ATOM 2509 H41 C B 78 5.239 18.303 -1.819 1.00 1.00 H +ATOM 2510 H42 C B 78 5.850 19.132 -3.239 1.00 1.00 H +ATOM 2511 H5 C B 78 4.519 19.521 -5.211 1.00 1.00 H +ATOM 2512 H6 C B 78 2.322 19.202 -6.248 1.00 1.00 H +ATOM 2513 P U B 79 -2.854 21.715 -5.522 1.00 1.00 P +ATOM 2514 OP1 U B 79 -4.165 22.025 -6.134 1.00 1.00 O +ATOM 2515 OP2 U B 79 -1.763 22.714 -5.564 1.00 1.00 O +ATOM 2516 O5' U B 79 -3.098 21.296 -3.987 1.00 1.00 O +ATOM 2517 C5' U B 79 -2.695 22.162 -2.924 1.00 1.00 C +ATOM 2518 C4' U B 79 -2.597 21.413 -1.599 1.00 1.00 C +ATOM 2519 O4' U B 79 -1.428 20.596 -1.586 1.00 1.00 O +ATOM 2520 C3' U B 79 -2.514 22.320 -0.381 1.00 1.00 C +ATOM 2521 O3' U B 79 -3.826 22.534 0.148 1.00 1.00 O +ATOM 2522 C2' U B 79 -1.685 21.527 0.617 1.00 1.00 C +ATOM 2523 O2' U B 79 -2.515 20.860 1.572 1.00 1.00 O +ATOM 2524 C1' U B 79 -0.927 20.520 -0.246 1.00 1.00 C +ATOM 2525 N1 U B 79 0.524 20.751 -0.288 1.00 1.00 N +ATOM 2526 C2 U B 79 1.206 20.660 0.910 1.00 1.00 C +ATOM 2527 O2 U B 79 0.633 20.426 1.972 1.00 1.00 O +ATOM 2528 N3 U B 79 2.574 20.852 0.846 1.00 1.00 N +ATOM 2529 C4 U B 79 3.309 21.121 -0.296 1.00 1.00 C +ATOM 2530 O4 U B 79 4.527 21.272 -0.235 1.00 1.00 O +ATOM 2531 C5 U B 79 2.516 21.198 -1.501 1.00 1.00 C +ATOM 2532 C6 U B 79 1.173 21.015 -1.464 1.00 1.00 C +ATOM 2533 H5' U B 79 -3.421 22.968 -2.826 1.00 1.00 H +ATOM 2534 H5'' U B 79 -1.720 22.585 -3.164 1.00 1.00 H +ATOM 2535 H4' U B 79 -3.467 20.767 -1.496 1.00 1.00 H +ATOM 2536 H3' U B 79 -2.026 23.263 -0.630 1.00 1.00 H +ATOM 2537 H2' U B 79 -0.976 22.189 1.120 1.00 1.00 H +ATOM 2538 HO2' U B 79 -3.220 20.424 1.085 1.00 1.00 H +ATOM 2539 H1' U B 79 -1.109 19.518 0.142 1.00 1.00 H +ATOM 2540 H3 U B 79 3.085 20.788 1.715 1.00 1.00 H +ATOM 2541 H5 U B 79 3.003 21.408 -2.453 1.00 1.00 H +ATOM 2542 H6 U B 79 0.600 21.080 -2.388 1.00 1.00 H +ATOM 2543 P A B 80 -4.165 23.860 0.996 1.00 1.00 P +ATOM 2544 OP1 A B 80 -5.605 23.837 1.337 1.00 1.00 O +ATOM 2545 OP2 A B 80 -3.595 25.025 0.282 1.00 1.00 O +ATOM 2546 O5' A B 80 -3.322 23.638 2.350 1.00 1.00 O +ATOM 2547 C5' A B 80 -3.579 22.508 3.187 1.00 1.00 C +ATOM 2548 C4' A B 80 -2.675 22.499 4.415 1.00 1.00 C +ATOM 2549 O4' A B 80 -1.309 22.390 3.996 1.00 1.00 O +ATOM 2550 C3' A B 80 -2.794 23.750 5.277 1.00 1.00 C +ATOM 2551 O3' A B 80 -2.721 23.382 6.658 1.00 1.00 O +ATOM 2552 C2' A B 80 -1.577 24.584 4.904 1.00 1.00 C +ATOM 2553 O2' A B 80 -1.068 25.298 6.035 1.00 1.00 O +ATOM 2554 C1' A B 80 -0.577 23.552 4.403 1.00 1.00 C +ATOM 2555 N9 A B 80 0.221 24.003 3.247 1.00 1.00 N +ATOM 2556 C8 A B 80 -0.198 24.633 2.104 1.00 1.00 C +ATOM 2557 N7 A B 80 0.765 24.907 1.268 1.00 1.00 N +ATOM 2558 C5 A B 80 1.905 24.423 1.903 1.00 1.00 C +ATOM 2559 C6 A B 80 3.261 24.405 1.535 1.00 1.00 C +ATOM 2560 N6 A B 80 3.711 24.907 0.385 1.00 1.00 N +ATOM 2561 N1 A B 80 4.125 23.848 2.399 1.00 1.00 N +ATOM 2562 C2 A B 80 3.670 23.348 3.542 1.00 1.00 C +ATOM 2563 N3 A B 80 2.427 23.304 3.999 1.00 1.00 N +ATOM 2564 C4 A B 80 1.583 23.870 3.110 1.00 1.00 C +ATOM 2565 H5' A B 80 -3.411 21.595 2.613 1.00 1.00 H +ATOM 2566 H5'' A B 80 -4.620 22.534 3.512 1.00 1.00 H +ATOM 2567 H4' A B 80 -2.916 21.629 5.024 1.00 1.00 H +ATOM 2568 H3' A B 80 -3.718 24.288 5.058 1.00 1.00 H +ATOM 2569 H2' A B 80 -1.835 25.274 4.096 1.00 1.00 H +ATOM 2570 HO2' A B 80 -0.643 26.091 5.702 1.00 1.00 H +ATOM 2571 H1' A B 80 0.096 23.283 5.216 1.00 1.00 H +ATOM 2572 H8 A B 80 -1.241 24.884 1.912 1.00 1.00 H +ATOM 2573 H61 A B 80 4.697 24.869 0.169 1.00 1.00 H +ATOM 2574 H62 A B 80 3.067 25.328 -0.270 1.00 1.00 H +ATOM 2575 H2 A B 80 4.425 22.912 4.195 1.00 1.00 H +ATOM 2576 P A B 81 -3.418 24.298 7.785 1.00 1.00 P +ATOM 2577 OP1 A B 81 -4.835 24.495 7.408 1.00 1.00 O +ATOM 2578 OP2 A B 81 -2.548 25.470 8.031 1.00 1.00 O +ATOM 2579 O5' A B 81 -3.370 23.353 9.090 1.00 1.00 O +ATOM 2580 C5' A B 81 -2.494 23.664 10.176 1.00 1.00 C +ATOM 2581 C4' A B 81 -2.042 22.404 10.915 1.00 1.00 C +ATOM 2582 O4' A B 81 -1.802 21.355 9.972 1.00 1.00 O +ATOM 2583 C3' A B 81 -0.768 22.591 11.736 1.00 1.00 C +ATOM 2584 O3' A B 81 -1.110 22.744 13.117 1.00 1.00 O +ATOM 2585 C2' A B 81 -0.003 21.291 11.538 1.00 1.00 C +ATOM 2586 O2' A B 81 -0.283 20.355 12.584 1.00 1.00 O +ATOM 2587 C1' A B 81 -0.507 20.786 10.193 1.00 1.00 C +ATOM 2588 N9 A B 81 0.345 21.169 9.052 1.00 1.00 N +ATOM 2589 C8 A B 81 0.091 22.078 8.058 1.00 1.00 C +ATOM 2590 N7 A B 81 1.055 22.191 7.187 1.00 1.00 N +ATOM 2591 C5 A B 81 2.017 21.291 7.637 1.00 1.00 C +ATOM 2592 C6 A B 81 3.286 20.935 7.149 1.00 1.00 C +ATOM 2593 N6 A B 81 3.821 21.469 6.051 1.00 1.00 N +ATOM 2594 N1 A B 81 3.973 20.010 7.839 1.00 1.00 N +ATOM 2595 C2 A B 81 3.434 19.483 8.931 1.00 1.00 C +ATOM 2596 N3 A B 81 2.259 19.733 9.488 1.00 1.00 N +ATOM 2597 C4 A B 81 1.592 20.665 8.773 1.00 1.00 C +ATOM 2598 H5' A B 81 -3.015 24.318 10.876 1.00 1.00 H +ATOM 2599 H5'' A B 81 -1.620 24.185 9.787 1.00 1.00 H +ATOM 2600 H4' A B 81 -2.842 22.086 11.583 1.00 1.00 H +ATOM 2601 H3' A B 81 -0.189 23.441 11.375 1.00 1.00 H +ATOM 2602 H2' A B 81 1.068 21.493 11.477 1.00 1.00 H +ATOM 2603 HO2' A B 81 -0.083 19.480 12.245 1.00 1.00 H +ATOM 2604 H1' A B 81 -0.591 19.701 10.227 1.00 1.00 H +ATOM 2605 H8 A B 81 -0.834 22.652 7.999 1.00 1.00 H +ATOM 2606 H61 A B 81 4.738 21.178 5.744 1.00 1.00 H +ATOM 2607 H62 A B 81 3.312 22.167 5.526 1.00 1.00 H +ATOM 2608 H2 A B 81 4.045 18.737 9.441 1.00 1.00 H +ATOM 2609 P G B 82 -0.310 23.784 14.053 1.00 1.00 P +ATOM 2610 OP1 G B 82 -0.966 23.812 15.379 1.00 1.00 O +ATOM 2611 OP2 G B 82 -0.126 25.041 13.294 1.00 1.00 O +ATOM 2612 O5' G B 82 1.128 23.083 14.222 1.00 1.00 O +ATOM 2613 C5' G B 82 1.250 21.830 14.899 1.00 1.00 C +ATOM 2614 C4' G B 82 2.678 21.294 14.836 1.00 1.00 C +ATOM 2615 O4' G B 82 2.992 20.946 13.483 1.00 1.00 O +ATOM 2616 C3' G B 82 3.736 22.290 15.309 1.00 1.00 C +ATOM 2617 O3' G B 82 4.132 21.974 16.647 1.00 1.00 O +ATOM 2618 C2' G B 82 4.904 22.052 14.366 1.00 1.00 C +ATOM 2619 O2' G B 82 5.806 21.071 14.886 1.00 1.00 O +ATOM 2620 C1' G B 82 4.225 21.563 13.100 1.00 1.00 C +ATOM 2621 N9 G B 82 3.912 22.639 12.146 1.00 1.00 N +ATOM 2622 C8 G B 82 2.761 23.374 12.023 1.00 1.00 C +ATOM 2623 N7 G B 82 2.794 24.251 11.058 1.00 1.00 N +ATOM 2624 C5 G B 82 4.059 24.088 10.501 1.00 1.00 C +ATOM 2625 C6 G B 82 4.669 24.770 9.411 1.00 1.00 C +ATOM 2626 O6 G B 82 4.202 25.669 8.715 1.00 1.00 O +ATOM 2627 N1 G B 82 5.953 24.299 9.172 1.00 1.00 N +ATOM 2628 C2 G B 82 6.575 23.299 9.888 1.00 1.00 C +ATOM 2629 N2 G B 82 7.813 22.983 9.506 1.00 1.00 N +ATOM 2630 N3 G B 82 6.004 22.657 10.911 1.00 1.00 N +ATOM 2631 C4 G B 82 4.750 23.102 11.160 1.00 1.00 C +ATOM 2632 H5' G B 82 0.578 21.109 14.435 1.00 1.00 H +ATOM 2633 H5'' G B 82 0.965 21.960 15.944 1.00 1.00 H +ATOM 2634 H4' G B 82 2.744 20.395 15.447 1.00 1.00 H +ATOM 2635 H3' G B 82 3.371 23.316 15.231 1.00 1.00 H +ATOM 2636 H2' G B 82 5.424 22.988 14.166 1.00 1.00 H +ATOM 2637 HO2' G B 82 5.532 20.879 15.785 1.00 1.00 H +ATOM 2638 H1' G B 82 4.860 20.825 12.611 1.00 1.00 H +ATOM 2639 H8 G B 82 1.895 23.236 12.670 1.00 1.00 H +ATOM 2640 H1 G B 82 6.451 24.738 8.410 1.00 1.00 H +ATOM 2641 H21 G B 82 8.243 23.470 8.731 1.00 1.00 H +ATOM 2642 H22 G B 82 8.322 22.258 9.991 1.00 1.00 H +ATOM 2643 P U B 83 4.396 23.146 17.721 1.00 1.00 P +ATOM 2644 OP1 U B 83 4.883 22.523 18.972 1.00 1.00 O +ATOM 2645 OP2 U B 83 3.204 24.022 17.749 1.00 1.00 O +ATOM 2646 O5' U B 83 5.613 23.972 17.066 1.00 1.00 O +ATOM 2647 C5' U B 83 6.967 23.560 17.264 1.00 1.00 C +ATOM 2648 C4' U B 83 7.946 24.536 16.616 1.00 1.00 C +ATOM 2649 O4' U B 83 7.816 24.481 15.193 1.00 1.00 O +ATOM 2650 C3' U B 83 7.731 25.986 17.021 1.00 1.00 C +ATOM 2651 O3' U B 83 8.538 26.308 18.165 1.00 1.00 O +ATOM 2652 C2' U B 83 8.213 26.763 15.807 1.00 1.00 C +ATOM 2653 O2' U B 83 9.598 27.111 15.921 1.00 1.00 O +ATOM 2654 C1' U B 83 7.968 25.800 14.647 1.00 1.00 C +ATOM 2655 N1 U B 83 6.743 26.101 13.881 1.00 1.00 N +ATOM 2656 C2 U B 83 6.869 26.890 12.754 1.00 1.00 C +ATOM 2657 O2 U B 83 7.952 27.346 12.391 1.00 1.00 O +ATOM 2658 N3 U B 83 5.702 27.138 12.052 1.00 1.00 N +ATOM 2659 C4 U B 83 4.439 26.673 12.379 1.00 1.00 C +ATOM 2660 O4 U B 83 3.468 26.956 11.681 1.00 1.00 O +ATOM 2661 C5 U B 83 4.403 25.857 13.571 1.00 1.00 C +ATOM 2662 C6 U B 83 5.533 25.600 14.275 1.00 1.00 C +ATOM 2663 H5' U B 83 7.106 22.571 16.826 1.00 1.00 H +ATOM 2664 H5'' U B 83 7.172 23.507 18.334 1.00 1.00 H +ATOM 2665 H4' U B 83 8.962 24.243 16.879 1.00 1.00 H +ATOM 2666 H3' U B 83 6.675 26.183 17.213 1.00 1.00 H +ATOM 2667 H2' U B 83 7.603 27.651 15.674 1.00 1.00 H +ATOM 2668 HO2' U B 83 9.642 28.053 16.109 1.00 1.00 H +ATOM 2669 H1' U B 83 8.828 25.815 13.974 1.00 1.00 H +ATOM 2670 H3 U B 83 5.778 27.713 11.226 1.00 1.00 H +ATOM 2671 H5 U B 83 3.453 25.444 13.911 1.00 1.00 H +ATOM 2672 H6 U B 83 5.475 24.982 15.170 1.00 1.00 H +ATOM 2673 P C B 84 7.989 27.321 19.296 1.00 1.00 P +ATOM 2674 OP1 C B 84 8.778 27.108 20.530 1.00 1.00 O +ATOM 2675 OP2 C B 84 6.514 27.215 19.337 1.00 1.00 O +ATOM 2676 O5' C B 84 8.373 28.769 18.700 1.00 1.00 O +ATOM 2677 C5' C B 84 9.731 29.217 18.682 1.00 1.00 C +ATOM 2678 C4' C B 84 9.938 30.316 17.642 1.00 1.00 C +ATOM 2679 O4' C B 84 9.427 29.875 16.389 1.00 1.00 O +ATOM 2680 C3' C B 84 9.239 31.632 17.953 1.00 1.00 C +ATOM 2681 O3' C B 84 10.121 32.496 18.681 1.00 1.00 O +ATOM 2682 C2' C B 84 8.964 32.213 16.571 1.00 1.00 C +ATOM 2683 O2' C B 84 10.028 33.067 16.139 1.00 1.00 O +ATOM 2684 C1' C B 84 8.844 30.978 15.682 1.00 1.00 C +ATOM 2685 N1 C B 84 7.446 30.608 15.366 1.00 1.00 N +ATOM 2686 C2 C B 84 6.945 30.992 14.132 1.00 1.00 C +ATOM 2687 O2 C B 84 7.652 31.628 13.352 1.00 1.00 O +ATOM 2688 N3 C B 84 5.666 30.646 13.817 1.00 1.00 N +ATOM 2689 C4 C B 84 4.910 29.953 14.679 1.00 1.00 C +ATOM 2690 N4 C B 84 3.661 29.631 14.341 1.00 1.00 N +ATOM 2691 C5 C B 84 5.421 29.558 15.954 1.00 1.00 C +ATOM 2692 C6 C B 84 6.688 29.904 16.256 1.00 1.00 C +ATOM 2693 H5' C B 84 10.382 28.375 18.445 1.00 1.00 H +ATOM 2694 H5'' C B 84 9.992 29.602 19.668 1.00 1.00 H +ATOM 2695 H4' C B 84 11.005 30.501 17.531 1.00 1.00 H +ATOM 2696 H3' C B 84 8.308 31.461 18.496 1.00 1.00 H +ATOM 2697 H2' C B 84 8.019 32.750 16.577 1.00 1.00 H +ATOM 2698 HO2' C B 84 10.802 32.841 16.656 1.00 1.00 H +ATOM 2699 H1' C B 84 9.395 31.144 14.754 1.00 1.00 H +ATOM 2700 H41 C B 84 3.296 29.908 13.443 1.00 1.00 H +ATOM 2701 H42 C B 84 3.081 29.109 14.982 1.00 1.00 H +ATOM 2702 H5 C B 84 4.808 28.994 16.658 1.00 1.00 H +ATOM 2703 H6 C B 84 7.111 29.619 17.219 1.00 1.00 H +ATOM 2704 P C B 85 9.532 33.651 19.643 1.00 1.00 P +ATOM 2705 OP1 C B 85 10.667 34.281 20.353 1.00 1.00 O +ATOM 2706 OP2 C B 85 8.406 33.080 20.415 1.00 1.00 O +ATOM 2707 O5' C B 85 8.934 34.726 18.602 1.00 1.00 O +ATOM 2708 C5' C B 85 9.806 35.539 17.810 1.00 1.00 C +ATOM 2709 C4' C B 85 9.041 36.300 16.730 1.00 1.00 C +ATOM 2710 O4' C B 85 8.307 35.391 15.920 1.00 1.00 O +ATOM 2711 C3' C B 85 8.028 37.300 17.264 1.00 1.00 C +ATOM 2712 O3' C B 85 8.648 38.576 17.455 1.00 1.00 O +ATOM 2713 C2' C B 85 6.998 37.389 16.149 1.00 1.00 C +ATOM 2714 O2' C B 85 7.267 38.487 15.274 1.00 1.00 O +ATOM 2715 C1' C B 85 7.134 36.051 15.422 1.00 1.00 C +ATOM 2716 N1 C B 85 5.990 35.139 15.633 1.00 1.00 N +ATOM 2717 C2 C B 85 4.977 35.155 14.686 1.00 1.00 C +ATOM 2718 O2 C B 85 5.051 35.910 13.720 1.00 1.00 O +ATOM 2719 N3 C B 85 3.915 34.321 14.862 1.00 1.00 N +ATOM 2720 C4 C B 85 3.850 33.505 15.924 1.00 1.00 C +ATOM 2721 N4 C B 85 2.795 32.702 16.068 1.00 1.00 N +ATOM 2722 C5 C B 85 4.893 33.486 16.903 1.00 1.00 C +ATOM 2723 C6 C B 85 5.939 34.313 16.719 1.00 1.00 C +ATOM 2724 H5' C B 85 10.554 34.903 17.335 1.00 1.00 H +ATOM 2725 H5'' C B 85 10.310 36.255 18.459 1.00 1.00 H +ATOM 2726 H4' C B 85 9.753 36.822 16.095 1.00 1.00 H +ATOM 2727 H3' C B 85 7.572 36.937 18.186 1.00 1.00 H +ATOM 2728 H2' C B 85 6.001 37.476 16.574 1.00 1.00 H +ATOM 2729 HO2' C B 85 8.220 38.584 15.218 1.00 1.00 H +ATOM 2730 H1' C B 85 7.255 36.236 14.354 1.00 1.00 H +ATOM 2731 H41 C B 85 2.053 32.714 15.377 1.00 1.00 H +ATOM 2732 H42 C B 85 2.736 32.083 16.865 1.00 1.00 H +ATOM 2733 H5 C B 85 4.842 32.823 17.767 1.00 1.00 H +ATOM 2734 H6 C B 85 6.753 34.324 17.443 1.00 1.00 H +ATOM 2735 P U B 86 8.026 39.640 18.493 1.00 1.00 P +ATOM 2736 OP1 U B 86 8.769 40.912 18.350 1.00 1.00 O +ATOM 2737 OP2 U B 86 7.925 38.989 19.818 1.00 1.00 O +ATOM 2738 O5' U B 86 6.534 39.862 17.925 1.00 1.00 O +ATOM 2739 C5' U B 86 6.326 40.485 16.655 1.00 1.00 C +ATOM 2740 C4' U B 86 4.851 40.486 16.257 1.00 1.00 C +ATOM 2741 O4' U B 86 4.393 39.156 16.069 1.00 1.00 O +ATOM 2742 C3' U B 86 3.919 41.115 17.288 1.00 1.00 C +ATOM 2743 O3' U B 86 3.667 42.491 16.986 1.00 1.00 O +ATOM 2744 C2' U B 86 2.635 40.281 17.188 1.00 1.00 C +ATOM 2745 O2' U B 86 1.535 41.073 16.730 1.00 1.00 O +ATOM 2746 C1' U B 86 2.975 39.177 16.188 1.00 1.00 C +ATOM 2747 N1 U B 86 2.529 37.831 16.607 1.00 1.00 N +ATOM 2748 C2 U B 86 1.340 37.360 16.084 1.00 1.00 C +ATOM 2749 O2 U B 86 0.665 38.020 15.297 1.00 1.00 O +ATOM 2750 N3 U B 86 0.950 36.100 16.500 1.00 1.00 N +ATOM 2751 C4 U B 86 1.636 35.282 17.382 1.00 1.00 C +ATOM 2752 O4 U B 86 1.195 34.175 17.681 1.00 1.00 O +ATOM 2753 C5 U B 86 2.867 35.854 17.878 1.00 1.00 C +ATOM 2754 C6 U B 86 3.270 37.088 17.485 1.00 1.00 C +ATOM 2755 H5' U B 86 6.897 39.949 15.898 1.00 1.00 H +ATOM 2756 H5'' U B 86 6.681 41.513 16.704 1.00 1.00 H +ATOM 2757 H4' U B 86 4.745 41.021 15.315 1.00 1.00 H +ATOM 2758 H3' U B 86 4.352 41.015 18.286 1.00 1.00 H +ATOM 2759 HO3' U B 86 4.444 42.988 17.251 1.00 1.00 H +ATOM 2760 H2' U B 86 2.406 39.834 18.159 1.00 1.00 H +ATOM 2761 HO2' U B 86 0.790 40.479 16.604 1.00 1.00 H +ATOM 2762 H1' U B 86 2.539 39.423 15.219 1.00 1.00 H +ATOM 2763 H3 U B 86 0.082 35.743 16.127 1.00 1.00 H +ATOM 2764 H5 U B 86 3.478 35.288 18.581 1.00 1.00 H +ATOM 2765 H6 U B 86 4.202 37.495 17.877 1.00 1.00 H +TER 2766 U B 86 +ENDMDL +MODEL 8 +ATOM 1 O5' G A 1 5.175 -40.085 7.787 1.00 1.00 O +ATOM 2 C5' G A 1 6.037 -40.968 7.067 1.00 1.00 C +ATOM 3 C4' G A 1 5.284 -41.699 5.958 1.00 1.00 C +ATOM 4 O4' G A 1 4.398 -42.662 6.533 1.00 1.00 O +ATOM 5 C3' G A 1 4.450 -40.781 5.070 1.00 1.00 C +ATOM 6 O3' G A 1 5.153 -40.514 3.853 1.00 1.00 O +ATOM 7 C2' G A 1 3.204 -41.592 4.770 1.00 1.00 C +ATOM 8 O2' G A 1 3.345 -42.344 3.559 1.00 1.00 O +ATOM 9 C1' G A 1 3.087 -42.504 5.979 1.00 1.00 C +ATOM 10 N9 G A 1 2.224 -41.964 7.037 1.00 1.00 N +ATOM 11 C8 G A 1 2.586 -41.363 8.215 1.00 1.00 C +ATOM 12 N7 G A 1 1.576 -40.990 8.950 1.00 1.00 N +ATOM 13 C5 G A 1 0.462 -41.371 8.207 1.00 1.00 C +ATOM 14 C6 G A 1 -0.922 -41.223 8.500 1.00 1.00 C +ATOM 15 O6 G A 1 -1.443 -40.716 9.491 1.00 1.00 O +ATOM 16 N1 G A 1 -1.716 -41.740 7.484 1.00 1.00 N +ATOM 17 C2 G A 1 -1.240 -42.328 6.330 1.00 1.00 C +ATOM 18 N2 G A 1 -2.157 -42.768 5.469 1.00 1.00 N +ATOM 19 N3 G A 1 0.061 -42.468 6.053 1.00 1.00 N +ATOM 20 C4 G A 1 0.850 -41.967 7.034 1.00 1.00 C +ATOM 21 H5' G A 1 6.460 -41.696 7.764 1.00 1.00 H +ATOM 22 H5'' G A 1 6.847 -40.396 6.622 1.00 1.00 H +ATOM 23 H4' G A 1 6.005 -42.228 5.337 1.00 1.00 H +ATOM 24 H3' G A 1 4.196 -39.858 5.593 1.00 1.00 H +ATOM 25 H2' G A 1 2.335 -40.934 4.717 1.00 1.00 H +ATOM 26 HO2' G A 1 4.239 -42.694 3.543 1.00 1.00 H +ATOM 27 H1' G A 1 2.707 -43.475 5.667 1.00 1.00 H +ATOM 28 H8 G A 1 3.623 -41.213 8.511 1.00 1.00 H +ATOM 29 H1 G A 1 -2.713 -41.671 7.621 1.00 1.00 H +ATOM 30 H21 G A 1 -3.140 -42.663 5.679 1.00 1.00 H +ATOM 31 H22 G A 1 -1.871 -43.208 4.606 1.00 1.00 H +ATOM 32 HO5' G A 1 5.729 -39.548 8.360 1.00 1.00 H +ATOM 33 P G A 2 4.821 -39.196 2.989 1.00 1.00 P +ATOM 34 OP1 G A 2 5.531 -39.302 1.696 1.00 1.00 O +ATOM 35 OP2 G A 2 5.031 -38.013 3.853 1.00 1.00 O +ATOM 36 O5' G A 2 3.240 -39.340 2.710 1.00 1.00 O +ATOM 37 C5' G A 2 2.738 -40.350 1.828 1.00 1.00 C +ATOM 38 C4' G A 2 1.219 -40.270 1.693 1.00 1.00 C +ATOM 39 O4' G A 2 0.596 -40.572 2.938 1.00 1.00 O +ATOM 40 C3' G A 2 0.707 -38.901 1.280 1.00 1.00 C +ATOM 41 O3' G A 2 0.646 -38.815 -0.150 1.00 1.00 O +ATOM 42 C2' G A 2 -0.693 -38.846 1.875 1.00 1.00 C +ATOM 43 O2' G A 2 -1.689 -39.211 0.913 1.00 1.00 O +ATOM 44 C1' G A 2 -0.638 -39.846 3.033 1.00 1.00 C +ATOM 45 N9 G A 2 -0.686 -39.215 4.363 1.00 1.00 N +ATOM 46 C8 G A 2 0.350 -38.790 5.154 1.00 1.00 C +ATOM 47 N7 G A 2 -0.031 -38.278 6.292 1.00 1.00 N +ATOM 48 C5 G A 2 -1.419 -38.371 6.254 1.00 1.00 C +ATOM 49 C6 G A 2 -2.387 -37.973 7.220 1.00 1.00 C +ATOM 50 O6 G A 2 -2.202 -37.451 8.317 1.00 1.00 O +ATOM 51 N1 G A 2 -3.678 -38.244 6.786 1.00 1.00 N +ATOM 52 C2 G A 2 -4.002 -38.826 5.579 1.00 1.00 C +ATOM 53 N2 G A 2 -5.301 -39.007 5.339 1.00 1.00 N +ATOM 54 N3 G A 2 -3.095 -39.200 4.672 1.00 1.00 N +ATOM 55 C4 G A 2 -1.829 -38.944 5.077 1.00 1.00 C +ATOM 56 H5' G A 2 3.012 -41.332 2.213 1.00 1.00 H +ATOM 57 H5'' G A 2 3.188 -40.217 0.844 1.00 1.00 H +ATOM 58 H4' G A 2 0.893 -41.005 0.959 1.00 1.00 H +ATOM 59 H3' G A 2 1.336 -38.112 1.697 1.00 1.00 H +ATOM 60 H2' G A 2 -0.884 -37.848 2.266 1.00 1.00 H +ATOM 61 HO2' G A 2 -2.493 -38.739 1.144 1.00 1.00 H +ATOM 62 H1' G A 2 -1.471 -40.542 2.948 1.00 1.00 H +ATOM 63 H8 G A 2 1.396 -38.869 4.859 1.00 1.00 H +ATOM 64 H1 G A 2 -4.422 -37.990 7.420 1.00 1.00 H +ATOM 65 H21 G A 2 -5.983 -38.724 6.024 1.00 1.00 H +ATOM 66 H22 G A 2 -5.600 -39.428 4.471 1.00 1.00 H +ATOM 67 P G A 3 0.688 -37.385 -0.893 1.00 1.00 P +ATOM 68 OP1 G A 3 0.783 -37.622 -2.351 1.00 1.00 O +ATOM 69 OP2 G A 3 1.700 -36.543 -0.217 1.00 1.00 O +ATOM 70 O5' G A 3 -0.770 -36.773 -0.577 1.00 1.00 O +ATOM 71 C5' G A 3 -1.951 -37.391 -1.101 1.00 1.00 C +ATOM 72 C4' G A 3 -3.221 -36.738 -0.557 1.00 1.00 C +ATOM 73 O4' G A 3 -3.215 -36.751 0.867 1.00 1.00 O +ATOM 74 C3' G A 3 -3.399 -35.285 -0.969 1.00 1.00 C +ATOM 75 O3' G A 3 -4.138 -35.221 -2.196 1.00 1.00 O +ATOM 76 C2' G A 3 -4.223 -34.689 0.160 1.00 1.00 C +ATOM 77 O2' G A 3 -5.614 -34.639 -0.176 1.00 1.00 O +ATOM 78 C1' G A 3 -3.963 -35.623 1.343 1.00 1.00 C +ATOM 79 N9 G A 3 -3.208 -34.994 2.441 1.00 1.00 N +ATOM 80 C8 G A 3 -1.871 -35.077 2.735 1.00 1.00 C +ATOM 81 N7 G A 3 -1.521 -34.411 3.800 1.00 1.00 N +ATOM 82 C5 G A 3 -2.711 -33.842 4.246 1.00 1.00 C +ATOM 83 C6 G A 3 -2.954 -33.006 5.370 1.00 1.00 C +ATOM 84 O6 G A 3 -2.152 -32.598 6.207 1.00 1.00 O +ATOM 85 N1 G A 3 -4.294 -32.652 5.459 1.00 1.00 N +ATOM 86 C2 G A 3 -5.278 -33.050 4.580 1.00 1.00 C +ATOM 87 N2 G A 3 -6.508 -32.603 4.829 1.00 1.00 N +ATOM 88 N3 G A 3 -5.051 -33.837 3.524 1.00 1.00 N +ATOM 89 C4 G A 3 -3.749 -34.193 3.420 1.00 1.00 C +ATOM 90 H5' G A 3 -1.951 -38.449 -0.832 1.00 1.00 H +ATOM 91 H5'' G A 3 -1.945 -37.301 -2.186 1.00 1.00 H +ATOM 92 H4' G A 3 -4.081 -37.309 -0.902 1.00 1.00 H +ATOM 93 H3' G A 3 -2.435 -34.783 -1.056 1.00 1.00 H +ATOM 94 H2' G A 3 -3.849 -33.692 0.397 1.00 1.00 H +ATOM 95 HO2' G A 3 -5.819 -33.731 -0.412 1.00 1.00 H +ATOM 96 H1' G A 3 -4.918 -35.975 1.733 1.00 1.00 H +ATOM 97 H8 G A 3 -1.164 -35.647 2.132 1.00 1.00 H +ATOM 98 H1 G A 3 -4.546 -32.056 6.235 1.00 1.00 H +ATOM 99 H21 G A 3 -6.679 -32.009 5.626 1.00 1.00 H +ATOM 100 H22 G A 3 -7.271 -32.862 4.219 1.00 1.00 H +ATOM 101 P A A 4 -4.054 -33.918 -3.139 1.00 1.00 P +ATOM 102 OP1 A A 4 -4.395 -34.324 -4.520 1.00 1.00 O +ATOM 103 OP2 A A 4 -2.769 -33.236 -2.869 1.00 1.00 O +ATOM 104 O5' A A 4 -5.248 -32.989 -2.579 1.00 1.00 O +ATOM 105 C5' A A 4 -6.619 -33.336 -2.808 1.00 1.00 C +ATOM 106 C4' A A 4 -7.568 -32.375 -2.096 1.00 1.00 C +ATOM 107 O4' A A 4 -7.429 -32.516 -0.684 1.00 1.00 O +ATOM 108 C3' A A 4 -7.321 -30.910 -2.423 1.00 1.00 C +ATOM 109 O3' A A 4 -8.158 -30.511 -3.513 1.00 1.00 O +ATOM 110 C2' A A 4 -7.737 -30.188 -1.154 1.00 1.00 C +ATOM 111 O2' A A 4 -9.114 -29.795 -1.204 1.00 1.00 O +ATOM 112 C1' A A 4 -7.493 -31.227 -0.062 1.00 1.00 C +ATOM 113 N9 A A 4 -6.232 -31.033 0.671 1.00 1.00 N +ATOM 114 C8 A A 4 -4.962 -31.381 0.295 1.00 1.00 C +ATOM 115 N7 A A 4 -4.047 -31.065 1.170 1.00 1.00 N +ATOM 116 C5 A A 4 -4.765 -30.465 2.199 1.00 1.00 C +ATOM 117 C6 A A 4 -4.373 -29.908 3.427 1.00 1.00 C +ATOM 118 N6 A A 4 -3.106 -29.865 3.838 1.00 1.00 N +ATOM 119 N1 A A 4 -5.341 -29.398 4.208 1.00 1.00 N +ATOM 120 C2 A A 4 -6.600 -29.443 3.792 1.00 1.00 C +ATOM 121 N3 A A 4 -7.092 -29.937 2.666 1.00 1.00 N +ATOM 122 C4 A A 4 -6.097 -30.440 1.903 1.00 1.00 C +ATOM 123 H5' A A 4 -6.798 -34.348 -2.444 1.00 1.00 H +ATOM 124 H5'' A A 4 -6.820 -33.303 -3.880 1.00 1.00 H +ATOM 125 H4' A A 4 -8.591 -32.629 -2.365 1.00 1.00 H +ATOM 126 H3' A A 4 -6.266 -30.733 -2.644 1.00 1.00 H +ATOM 127 H2' A A 4 -7.093 -29.320 -0.992 1.00 1.00 H +ATOM 128 HO2' A A 4 -9.544 -30.164 -0.430 1.00 1.00 H +ATOM 129 H1' A A 4 -8.322 -31.211 0.645 1.00 1.00 H +ATOM 130 H8 A A 4 -4.734 -31.877 -0.650 1.00 1.00 H +ATOM 131 H61 A A 4 -2.877 -29.453 4.729 1.00 1.00 H +ATOM 132 H62 A A 4 -2.374 -30.246 3.256 1.00 1.00 H +ATOM 133 H2 A A 4 -7.334 -29.012 4.474 1.00 1.00 H +ATOM 134 P U A 5 -7.708 -29.315 -4.493 1.00 1.00 P +ATOM 135 OP1 U A 5 -8.803 -29.072 -5.459 1.00 1.00 O +ATOM 136 OP2 U A 5 -6.343 -29.607 -4.984 1.00 1.00 O +ATOM 137 O5' U A 5 -7.627 -28.053 -3.496 1.00 1.00 O +ATOM 138 C5' U A 5 -8.814 -27.500 -2.922 1.00 1.00 C +ATOM 139 C4' U A 5 -8.486 -26.554 -1.771 1.00 1.00 C +ATOM 140 O4' U A 5 -7.723 -27.245 -0.789 1.00 1.00 O +ATOM 141 C3' U A 5 -7.675 -25.338 -2.184 1.00 1.00 C +ATOM 142 O3' U A 5 -8.564 -24.256 -2.483 1.00 1.00 O +ATOM 143 C2' U A 5 -6.851 -25.013 -0.943 1.00 1.00 C +ATOM 144 O2' U A 5 -7.477 -23.994 -0.155 1.00 1.00 O +ATOM 145 C1' U A 5 -6.789 -26.343 -0.184 1.00 1.00 C +ATOM 146 N1 U A 5 -5.463 -26.997 -0.223 1.00 1.00 N +ATOM 147 C2 U A 5 -4.632 -26.830 0.868 1.00 1.00 C +ATOM 148 O2 U A 5 -4.966 -26.170 1.849 1.00 1.00 O +ATOM 149 N3 U A 5 -3.399 -27.453 0.794 1.00 1.00 N +ATOM 150 C4 U A 5 -2.932 -28.217 -0.262 1.00 1.00 C +ATOM 151 O4 U A 5 -1.813 -28.725 -0.221 1.00 1.00 O +ATOM 152 C5 U A 5 -3.866 -28.337 -1.359 1.00 1.00 C +ATOM 153 C6 U A 5 -5.079 -27.736 -1.309 1.00 1.00 C +ATOM 154 H5' U A 5 -9.443 -28.310 -2.549 1.00 1.00 H +ATOM 155 H5'' U A 5 -9.358 -26.950 -3.689 1.00 1.00 H +ATOM 156 H4' U A 5 -9.415 -26.221 -1.313 1.00 1.00 H +ATOM 157 H3' U A 5 -7.029 -25.569 -3.032 1.00 1.00 H +ATOM 158 H2' U A 5 -5.845 -24.708 -1.237 1.00 1.00 H +ATOM 159 HO2' U A 5 -8.425 -24.069 -0.292 1.00 1.00 H +ATOM 160 H1' U A 5 -7.079 -26.175 0.855 1.00 1.00 H +ATOM 161 H3 U A 5 -2.781 -27.340 1.585 1.00 1.00 H +ATOM 162 H5 U A 5 -3.590 -28.920 -2.238 1.00 1.00 H +ATOM 163 H6 U A 5 -5.765 -27.846 -2.149 1.00 1.00 H +ATOM 164 P A A 6 -8.439 -23.456 -3.875 1.00 1.00 P +ATOM 165 OP1 A A 6 -9.780 -22.942 -4.235 1.00 1.00 O +ATOM 166 OP2 A A 6 -7.696 -24.306 -4.831 1.00 1.00 O +ATOM 167 O5' A A 6 -7.508 -22.205 -3.484 1.00 1.00 O +ATOM 168 C5' A A 6 -8.073 -20.899 -3.342 1.00 1.00 C +ATOM 169 C4' A A 6 -8.234 -20.519 -1.874 1.00 1.00 C +ATOM 170 O4' A A 6 -7.194 -21.134 -1.111 1.00 1.00 O +ATOM 171 C3' A A 6 -8.184 -19.015 -1.617 1.00 1.00 C +ATOM 172 O3' A A 6 -9.229 -18.655 -0.706 1.00 1.00 O +ATOM 173 C2' A A 6 -6.828 -18.778 -0.963 1.00 1.00 C +ATOM 174 O2' A A 6 -6.916 -17.796 0.075 1.00 1.00 O +ATOM 175 C1' A A 6 -6.446 -20.142 -0.402 1.00 1.00 C +ATOM 176 N9 A A 6 -5.018 -20.480 -0.550 1.00 1.00 N +ATOM 177 C8 A A 6 -4.363 -20.966 -1.653 1.00 1.00 C +ATOM 178 N7 A A 6 -3.091 -21.178 -1.462 1.00 1.00 N +ATOM 179 C5 A A 6 -2.887 -20.804 -0.137 1.00 1.00 C +ATOM 180 C6 A A 6 -1.744 -20.792 0.681 1.00 1.00 C +ATOM 181 N6 A A 6 -0.542 -21.185 0.260 1.00 1.00 N +ATOM 182 N1 A A 6 -1.896 -20.360 1.944 1.00 1.00 N +ATOM 183 C2 A A 6 -3.096 -19.972 2.357 1.00 1.00 C +ATOM 184 N3 A A 6 -4.239 -19.939 1.689 1.00 1.00 N +ATOM 185 C4 A A 6 -4.056 -20.377 0.426 1.00 1.00 C +ATOM 186 H5' A A 6 -9.051 -20.881 -3.823 1.00 1.00 H +ATOM 187 H5'' A A 6 -7.422 -20.174 -3.829 1.00 1.00 H +ATOM 188 H4' A A 6 -9.190 -20.900 -1.518 1.00 1.00 H +ATOM 189 H3' A A 6 -8.267 -18.457 -2.551 1.00 1.00 H +ATOM 190 H2' A A 6 -6.100 -18.472 -1.719 1.00 1.00 H +ATOM 191 HO2' A A 6 -7.478 -17.088 -0.248 1.00 1.00 H +ATOM 192 H1' A A 6 -6.714 -20.181 0.653 1.00 1.00 H +ATOM 193 H8 A A 6 -4.862 -21.154 -2.605 1.00 1.00 H +ATOM 194 H61 A A 6 0.248 -21.155 0.891 1.00 1.00 H +ATOM 195 H62 A A 6 -0.413 -21.512 -0.691 1.00 1.00 H +ATOM 196 H2 A A 6 -3.147 -19.632 3.391 1.00 1.00 H +ATOM 197 P U A 7 -9.736 -17.131 -0.609 1.00 1.00 P +ATOM 198 OP1 U A 7 -11.200 -17.141 -0.391 1.00 1.00 O +ATOM 199 OP2 U A 7 -9.166 -16.380 -1.750 1.00 1.00 O +ATOM 200 O5' U A 7 -9.028 -16.608 0.738 1.00 1.00 O +ATOM 201 C5' U A 7 -9.763 -16.528 1.962 1.00 1.00 C +ATOM 202 C4' U A 7 -8.884 -16.866 3.164 1.00 1.00 C +ATOM 203 O4' U A 7 -8.999 -18.258 3.455 1.00 1.00 O +ATOM 204 C3' U A 7 -7.399 -16.559 2.951 1.00 1.00 C +ATOM 205 O3' U A 7 -6.943 -15.657 3.961 1.00 1.00 O +ATOM 206 C2' U A 7 -6.693 -17.899 3.122 1.00 1.00 C +ATOM 207 O2' U A 7 -5.499 -17.772 3.900 1.00 1.00 O +ATOM 208 C1' U A 7 -7.720 -18.755 3.837 1.00 1.00 C +ATOM 209 N1 U A 7 -7.651 -20.190 3.487 1.00 1.00 N +ATOM 210 C2 U A 7 -8.833 -20.906 3.513 1.00 1.00 C +ATOM 211 O2 U A 7 -9.903 -20.389 3.822 1.00 1.00 O +ATOM 212 N3 U A 7 -8.739 -22.245 3.175 1.00 1.00 N +ATOM 213 C4 U A 7 -7.583 -22.918 2.814 1.00 1.00 C +ATOM 214 O4 U A 7 -7.617 -24.114 2.533 1.00 1.00 O +ATOM 215 C5 U A 7 -6.397 -22.091 2.812 1.00 1.00 C +ATOM 216 C6 U A 7 -6.464 -20.778 3.141 1.00 1.00 C +ATOM 217 H5' U A 7 -10.596 -17.228 1.924 1.00 1.00 H +ATOM 218 H5'' U A 7 -10.152 -15.516 2.079 1.00 1.00 H +ATOM 219 H4' U A 7 -9.239 -16.307 4.026 1.00 1.00 H +ATOM 220 H3' U A 7 -7.222 -16.153 1.953 1.00 1.00 H +ATOM 221 H2' U A 7 -6.473 -18.329 2.142 1.00 1.00 H +ATOM 222 HO2' U A 7 -5.477 -18.510 4.513 1.00 1.00 H +ATOM 223 H1' U A 7 -7.597 -18.642 4.913 1.00 1.00 H +ATOM 224 H3 U A 7 -9.594 -22.781 3.191 1.00 1.00 H +ATOM 225 H5 U A 7 -5.437 -22.530 2.542 1.00 1.00 H +ATOM 226 H6 U A 7 -5.554 -20.178 3.130 1.00 1.00 H +ATOM 227 P G A 8 -5.656 -14.732 3.691 1.00 1.00 P +ATOM 228 OP1 G A 8 -5.244 -14.123 4.975 1.00 1.00 O +ATOM 229 OP2 G A 8 -5.946 -13.870 2.524 1.00 1.00 O +ATOM 230 O5' G A 8 -4.535 -15.805 3.260 1.00 1.00 O +ATOM 231 C5' G A 8 -3.511 -16.192 4.181 1.00 1.00 C +ATOM 232 C4' G A 8 -2.124 -15.934 3.605 1.00 1.00 C +ATOM 233 O4' G A 8 -1.725 -17.049 2.800 1.00 1.00 O +ATOM 234 C3' G A 8 -2.055 -14.687 2.735 1.00 1.00 C +ATOM 235 O3' G A 8 -1.452 -13.616 3.469 1.00 1.00 O +ATOM 236 C2' G A 8 -1.149 -15.080 1.582 1.00 1.00 C +ATOM 237 O2' G A 8 0.196 -14.669 1.817 1.00 1.00 O +ATOM 238 C1' G A 8 -1.252 -16.592 1.527 1.00 1.00 C +ATOM 239 N9 G A 8 -2.187 -17.072 0.501 1.00 1.00 N +ATOM 240 C8 G A 8 -3.488 -17.470 0.660 1.00 1.00 C +ATOM 241 N7 G A 8 -4.067 -17.844 -0.445 1.00 1.00 N +ATOM 242 C5 G A 8 -3.079 -17.686 -1.412 1.00 1.00 C +ATOM 243 C6 G A 8 -3.130 -17.937 -2.811 1.00 1.00 C +ATOM 244 O6 G A 8 -4.076 -18.351 -3.479 1.00 1.00 O +ATOM 245 N1 G A 8 -1.919 -17.649 -3.425 1.00 1.00 N +ATOM 246 C2 G A 8 -0.797 -17.177 -2.777 1.00 1.00 C +ATOM 247 N2 G A 8 0.274 -16.962 -3.540 1.00 1.00 N +ATOM 248 N3 G A 8 -0.746 -16.938 -1.460 1.00 1.00 N +ATOM 249 C4 G A 8 -1.922 -17.213 -0.844 1.00 1.00 C +ATOM 250 H5' G A 8 -3.613 -17.255 4.403 1.00 1.00 H +ATOM 251 H5'' G A 8 -3.626 -15.621 5.101 1.00 1.00 H +ATOM 252 H4' G A 8 -1.417 -15.830 4.427 1.00 1.00 H +ATOM 253 H3' G A 8 -3.047 -14.413 2.375 1.00 1.00 H +ATOM 254 H2' G A 8 -1.529 -14.656 0.653 1.00 1.00 H +ATOM 255 HO2' G A 8 0.233 -13.720 1.678 1.00 1.00 H +ATOM 256 H1' G A 8 -0.268 -17.013 1.336 1.00 1.00 H +ATOM 257 H8 G A 8 -3.993 -17.479 1.626 1.00 1.00 H +ATOM 258 H1 G A 8 -1.880 -17.802 -4.422 1.00 1.00 H +ATOM 259 H21 G A 8 0.232 -17.144 -4.531 1.00 1.00 H +ATOM 260 H22 G A 8 1.126 -16.620 -3.129 1.00 1.00 H +ATOM 261 P G A 9 -1.113 -12.207 2.758 1.00 1.00 P +ATOM 262 OP1 G A 9 -0.232 -12.470 1.601 1.00 1.00 O +ATOM 263 OP2 G A 9 -0.672 -11.264 3.810 1.00 1.00 O +ATOM 264 O5' G A 9 -2.557 -11.713 2.219 1.00 1.00 O +ATOM 265 C5' G A 9 -2.959 -11.887 0.851 1.00 1.00 C +ATOM 266 C4' G A 9 -1.859 -11.474 -0.127 1.00 1.00 C +ATOM 267 O4' G A 9 -1.280 -12.647 -0.707 1.00 1.00 O +ATOM 268 C3' G A 9 -2.325 -10.581 -1.274 1.00 1.00 C +ATOM 269 O3' G A 9 -2.024 -9.220 -0.959 1.00 1.00 O +ATOM 270 C2' G A 9 -1.477 -11.034 -2.453 1.00 1.00 C +ATOM 271 O2' G A 9 -0.277 -10.258 -2.560 1.00 1.00 O +ATOM 272 C1' G A 9 -1.171 -12.488 -2.124 1.00 1.00 C +ATOM 273 N9 G A 9 -2.098 -13.447 -2.752 1.00 1.00 N +ATOM 274 C8 G A 9 -2.990 -14.298 -2.149 1.00 1.00 C +ATOM 275 N7 G A 9 -3.681 -15.020 -2.986 1.00 1.00 N +ATOM 276 C5 G A 9 -3.215 -14.622 -4.236 1.00 1.00 C +ATOM 277 C6 G A 9 -3.597 -15.061 -5.534 1.00 1.00 C +ATOM 278 O6 G A 9 -4.438 -15.905 -5.837 1.00 1.00 O +ATOM 279 N1 G A 9 -2.881 -14.404 -6.526 1.00 1.00 N +ATOM 280 C2 G A 9 -1.917 -13.444 -6.302 1.00 1.00 C +ATOM 281 N2 G A 9 -1.337 -12.925 -7.384 1.00 1.00 N +ATOM 282 N3 G A 9 -1.557 -13.028 -5.083 1.00 1.00 N +ATOM 283 C4 G A 9 -2.245 -13.659 -4.102 1.00 1.00 C +ATOM 284 H5' G A 9 -3.847 -11.283 0.667 1.00 1.00 H +ATOM 285 H5'' G A 9 -3.206 -12.932 0.684 1.00 1.00 H +ATOM 286 H4' G A 9 -1.083 -10.953 0.427 1.00 1.00 H +ATOM 287 H3' G A 9 -3.389 -10.721 -1.480 1.00 1.00 H +ATOM 288 H2' G A 9 -2.058 -10.978 -3.378 1.00 1.00 H +ATOM 289 HO2' G A 9 0.454 -10.826 -2.304 1.00 1.00 H +ATOM 290 H1' G A 9 -0.155 -12.722 -2.435 1.00 1.00 H +ATOM 291 H8 G A 9 -3.108 -14.366 -1.067 1.00 1.00 H +ATOM 292 H1 G A 9 -3.098 -14.664 -7.477 1.00 1.00 H +ATOM 293 H21 G A 9 -1.611 -13.241 -8.307 1.00 1.00 H +ATOM 294 H22 G A 9 -0.623 -12.218 -7.285 1.00 1.00 H +ATOM 295 P A A 10 -3.205 -8.139 -0.800 1.00 1.00 P +ATOM 296 OP1 A A 10 -2.730 -7.062 0.097 1.00 1.00 O +ATOM 297 OP2 A A 10 -4.455 -8.865 -0.485 1.00 1.00 O +ATOM 298 O5' A A 10 -3.327 -7.540 -2.287 1.00 1.00 O +ATOM 299 C5' A A 10 -2.215 -6.873 -2.890 1.00 1.00 C +ATOM 300 C4' A A 10 -2.353 -6.816 -4.406 1.00 1.00 C +ATOM 301 O4' A A 10 -2.325 -8.129 -4.950 1.00 1.00 O +ATOM 302 C3' A A 10 -3.644 -6.181 -4.894 1.00 1.00 C +ATOM 303 O3' A A 10 -3.465 -4.767 -5.029 1.00 1.00 O +ATOM 304 C2' A A 10 -3.865 -6.824 -6.255 1.00 1.00 C +ATOM 305 O2' A A 10 -3.348 -6.004 -7.309 1.00 1.00 O +ATOM 306 C1' A A 10 -3.101 -8.150 -6.154 1.00 1.00 C +ATOM 307 N9 A A 10 -3.970 -9.339 -6.101 1.00 1.00 N +ATOM 308 C8 A A 10 -4.470 -10.000 -5.007 1.00 1.00 C +ATOM 309 N7 A A 10 -5.212 -11.029 -5.307 1.00 1.00 N +ATOM 310 C5 A A 10 -5.203 -11.052 -6.699 1.00 1.00 C +ATOM 311 C6 A A 10 -5.806 -11.907 -7.638 1.00 1.00 C +ATOM 312 N6 A A 10 -6.567 -12.947 -7.295 1.00 1.00 N +ATOM 313 N1 A A 10 -5.593 -11.642 -8.937 1.00 1.00 N +ATOM 314 C2 A A 10 -4.834 -10.605 -9.272 1.00 1.00 C +ATOM 315 N3 A A 10 -4.216 -9.735 -8.488 1.00 1.00 N +ATOM 316 C4 A A 10 -4.449 -10.025 -7.190 1.00 1.00 C +ATOM 317 H5' A A 10 -1.298 -7.407 -2.635 1.00 1.00 H +ATOM 318 H5'' A A 10 -2.155 -5.858 -2.500 1.00 1.00 H +ATOM 319 H4' A A 10 -1.511 -6.259 -4.814 1.00 1.00 H +ATOM 320 H3' A A 10 -4.469 -6.414 -4.217 1.00 1.00 H +ATOM 321 H2' A A 10 -4.930 -7.020 -6.403 1.00 1.00 H +ATOM 322 HO2' A A 10 -3.937 -6.102 -8.062 1.00 1.00 H +ATOM 323 H1' A A 10 -2.431 -8.240 -7.008 1.00 1.00 H +ATOM 324 H8 A A 10 -4.266 -9.692 -3.981 1.00 1.00 H +ATOM 325 H61 A A 10 -6.981 -13.533 -8.013 1.00 1.00 H +ATOM 326 H62 A A 10 -6.732 -13.151 -6.320 1.00 1.00 H +ATOM 327 H2 A A 10 -4.702 -10.448 -10.342 1.00 1.00 H +ATOM 328 P A A 11 -4.732 -3.774 -5.045 1.00 1.00 P +ATOM 329 OP1 A A 11 -4.235 -2.385 -4.926 1.00 1.00 O +ATOM 330 OP2 A A 11 -5.733 -4.283 -4.082 1.00 1.00 O +ATOM 331 O5' A A 11 -5.316 -3.974 -6.534 1.00 1.00 O +ATOM 332 C5' A A 11 -4.517 -3.640 -7.671 1.00 1.00 C +ATOM 333 C4' A A 11 -5.019 -4.324 -8.943 1.00 1.00 C +ATOM 334 O4' A A 11 -5.158 -5.731 -8.731 1.00 1.00 O +ATOM 335 C3' A A 11 -6.373 -3.825 -9.422 1.00 1.00 C +ATOM 336 O3' A A 11 -6.184 -2.736 -10.334 1.00 1.00 O +ATOM 337 C2' A A 11 -6.938 -5.015 -10.168 1.00 1.00 C +ATOM 338 O2' A A 11 -6.650 -4.945 -11.569 1.00 1.00 O +ATOM 339 C1' A A 11 -6.255 -6.214 -9.521 1.00 1.00 C +ATOM 340 N9 A A 11 -7.150 -7.026 -8.679 1.00 1.00 N +ATOM 341 C8 A A 11 -7.572 -6.818 -7.390 1.00 1.00 C +ATOM 342 N7 A A 11 -8.384 -7.736 -6.946 1.00 1.00 N +ATOM 343 C5 A A 11 -8.510 -8.615 -8.019 1.00 1.00 C +ATOM 344 C6 A A 11 -9.238 -9.805 -8.191 1.00 1.00 C +ATOM 345 N6 A A 11 -10.008 -10.334 -7.240 1.00 1.00 N +ATOM 346 N1 A A 11 -9.137 -10.422 -9.381 1.00 1.00 N +ATOM 347 C2 A A 11 -8.367 -9.890 -10.323 1.00 1.00 C +ATOM 348 N3 A A 11 -7.638 -8.785 -10.283 1.00 1.00 N +ATOM 349 C4 A A 11 -7.761 -8.189 -9.077 1.00 1.00 C +ATOM 350 H5' A A 11 -3.486 -3.944 -7.485 1.00 1.00 H +ATOM 351 H5'' A A 11 -4.548 -2.560 -7.819 1.00 1.00 H +ATOM 352 H4' A A 11 -4.285 -4.166 -9.733 1.00 1.00 H +ATOM 353 H3' A A 11 -7.009 -3.543 -8.582 1.00 1.00 H +ATOM 354 H2' A A 11 -8.017 -5.072 -10.002 1.00 1.00 H +ATOM 355 HO2' A A 11 -5.955 -4.294 -11.683 1.00 1.00 H +ATOM 356 H1' A A 11 -5.856 -6.852 -10.311 1.00 1.00 H +ATOM 357 H8 A A 11 -7.258 -5.962 -6.792 1.00 1.00 H +ATOM 358 H61 A A 11 -10.512 -11.190 -7.415 1.00 1.00 H +ATOM 359 H62 A A 11 -10.093 -9.876 -6.351 1.00 1.00 H +ATOM 360 H2 A A 11 -8.331 -10.441 -11.264 1.00 1.00 H +ATOM 361 P G A 12 -7.428 -1.828 -10.805 1.00 1.00 P +ATOM 362 OP1 G A 12 -6.889 -0.642 -11.508 1.00 1.00 O +ATOM 363 OP2 G A 12 -8.334 -1.647 -9.649 1.00 1.00 O +ATOM 364 O5' G A 12 -8.176 -2.760 -11.891 1.00 1.00 O +ATOM 365 C5' G A 12 -7.719 -2.816 -13.250 1.00 1.00 C +ATOM 366 C4' G A 12 -8.811 -3.324 -14.195 1.00 1.00 C +ATOM 367 O4' G A 12 -8.725 -4.751 -14.336 1.00 1.00 O +ATOM 368 C3' G A 12 -10.225 -2.994 -13.725 1.00 1.00 C +ATOM 369 O3' G A 12 -10.693 -1.803 -14.373 1.00 1.00 O +ATOM 370 C2' G A 12 -11.042 -4.186 -14.188 1.00 1.00 C +ATOM 371 O2' G A 12 -11.575 -3.978 -15.499 1.00 1.00 O +ATOM 372 C1' G A 12 -10.030 -5.324 -14.172 1.00 1.00 C +ATOM 373 N9 G A 12 -10.009 -6.093 -12.921 1.00 1.00 N +ATOM 374 C8 G A 12 -8.957 -6.288 -12.064 1.00 1.00 C +ATOM 375 N7 G A 12 -9.253 -7.008 -11.018 1.00 1.00 N +ATOM 376 C5 G A 12 -10.600 -7.313 -11.192 1.00 1.00 C +ATOM 377 C6 G A 12 -11.476 -8.075 -10.368 1.00 1.00 C +ATOM 378 O6 G A 12 -11.226 -8.640 -9.306 1.00 1.00 O +ATOM 379 N1 G A 12 -12.754 -8.136 -10.907 1.00 1.00 N +ATOM 380 C2 G A 12 -13.145 -7.542 -12.088 1.00 1.00 C +ATOM 381 N2 G A 12 -14.419 -7.712 -12.441 1.00 1.00 N +ATOM 382 N3 G A 12 -12.323 -6.829 -12.863 1.00 1.00 N +ATOM 383 C4 G A 12 -11.072 -6.756 -12.353 1.00 1.00 C +ATOM 384 H5' G A 12 -6.862 -3.483 -13.310 1.00 1.00 H +ATOM 385 H5'' G A 12 -7.414 -1.816 -13.563 1.00 1.00 H +ATOM 386 H4' G A 12 -8.658 -2.876 -15.175 1.00 1.00 H +ATOM 387 H3' G A 12 -10.260 -2.896 -12.638 1.00 1.00 H +ATOM 388 H2' G A 12 -11.839 -4.393 -13.473 1.00 1.00 H +ATOM 389 HO2' G A 12 -11.031 -3.310 -15.925 1.00 1.00 H +ATOM 390 H1' G A 12 -10.231 -6.005 -15.000 1.00 1.00 H +ATOM 391 H8 G A 12 -7.963 -5.878 -12.240 1.00 1.00 H +ATOM 392 H1 G A 12 -13.434 -8.662 -10.377 1.00 1.00 H +ATOM 393 H21 G A 12 -15.038 -8.254 -11.853 1.00 1.00 H +ATOM 394 H22 G A 12 -14.765 -7.301 -13.295 1.00 1.00 H +ATOM 395 P A A 13 -11.426 -0.640 -13.526 1.00 1.00 P +ATOM 396 OP1 A A 13 -11.249 0.639 -14.249 1.00 1.00 O +ATOM 397 OP2 A A 13 -10.993 -0.752 -12.114 1.00 1.00 O +ATOM 398 O5' A A 13 -12.981 -1.055 -13.611 1.00 1.00 O +ATOM 399 C5' A A 13 -13.690 -0.982 -14.853 1.00 1.00 C +ATOM 400 C4' A A 13 -15.030 -1.709 -14.777 1.00 1.00 C +ATOM 401 O4' A A 13 -14.805 -3.102 -14.542 1.00 1.00 O +ATOM 402 C3' A A 13 -15.949 -1.208 -13.667 1.00 1.00 C +ATOM 403 O3' A A 13 -16.873 -0.249 -14.197 1.00 1.00 O +ATOM 404 C2' A A 13 -16.692 -2.458 -13.230 1.00 1.00 C +ATOM 405 O2' A A 13 -17.901 -2.638 -13.975 1.00 1.00 O +ATOM 406 C1' A A 13 -15.686 -3.566 -13.513 1.00 1.00 C +ATOM 407 N9 A A 13 -14.862 -3.919 -12.349 1.00 1.00 N +ATOM 408 C8 A A 13 -13.653 -3.400 -11.962 1.00 1.00 C +ATOM 409 N7 A A 13 -13.176 -3.932 -10.870 1.00 1.00 N +ATOM 410 C5 A A 13 -14.140 -4.868 -10.508 1.00 1.00 C +ATOM 411 C6 A A 13 -14.232 -5.769 -9.434 1.00 1.00 C +ATOM 412 N6 A A 13 -13.298 -5.875 -8.486 1.00 1.00 N +ATOM 413 N1 A A 13 -15.322 -6.553 -9.378 1.00 1.00 N +ATOM 414 C2 A A 13 -16.247 -6.443 -10.324 1.00 1.00 C +ATOM 415 N3 A A 13 -16.276 -5.640 -11.376 1.00 1.00 N +ATOM 416 C4 A A 13 -15.170 -4.867 -11.405 1.00 1.00 C +ATOM 417 H5' A A 13 -13.084 -1.435 -15.636 1.00 1.00 H +ATOM 418 H5'' A A 13 -13.866 0.066 -15.100 1.00 1.00 H +ATOM 419 H4' A A 13 -15.541 -1.602 -15.731 1.00 1.00 H +ATOM 420 H3' A A 13 -15.370 -0.790 -12.841 1.00 1.00 H +ATOM 421 H2' A A 13 -16.899 -2.413 -12.160 1.00 1.00 H +ATOM 422 HO2' A A 13 -18.613 -2.250 -13.458 1.00 1.00 H +ATOM 423 H1' A A 13 -16.210 -4.459 -13.858 1.00 1.00 H +ATOM 424 H8 A A 13 -13.137 -2.616 -12.517 1.00 1.00 H +ATOM 425 H61 A A 13 -13.415 -6.543 -7.732 1.00 1.00 H +ATOM 426 H62 A A 13 -12.476 -5.290 -8.520 1.00 1.00 H +ATOM 427 H2 A A 13 -17.106 -7.108 -10.217 1.00 1.00 H +ATOM 428 P A A 14 -17.197 1.114 -13.398 1.00 1.00 P +ATOM 429 OP1 A A 14 -17.954 2.009 -14.301 1.00 1.00 O +ATOM 430 OP2 A A 14 -15.942 1.589 -12.771 1.00 1.00 O +ATOM 431 O5' A A 14 -18.190 0.625 -12.226 1.00 1.00 O +ATOM 432 C5' A A 14 -19.588 0.447 -12.480 1.00 1.00 C +ATOM 433 C4' A A 14 -20.329 -0.030 -11.233 1.00 1.00 C +ATOM 434 O4' A A 14 -19.885 -1.341 -10.878 1.00 1.00 O +ATOM 435 C3' A A 14 -20.121 0.857 -10.014 1.00 1.00 C +ATOM 436 O3' A A 14 -21.179 1.820 -9.929 1.00 1.00 O +ATOM 437 C2' A A 14 -20.205 -0.116 -8.851 1.00 1.00 C +ATOM 438 O2' A A 14 -21.547 -0.245 -8.367 1.00 1.00 O +ATOM 439 C1' A A 14 -19.704 -1.421 -9.457 1.00 1.00 C +ATOM 440 N9 A A 14 -18.276 -1.677 -9.212 1.00 1.00 N +ATOM 441 C8 A A 14 -17.191 -1.216 -9.912 1.00 1.00 C +ATOM 442 N7 A A 14 -16.046 -1.631 -9.443 1.00 1.00 N +ATOM 443 C5 A A 14 -16.399 -2.421 -8.354 1.00 1.00 C +ATOM 444 C6 A A 14 -15.638 -3.153 -7.426 1.00 1.00 C +ATOM 445 N6 A A 14 -14.306 -3.207 -7.454 1.00 1.00 N +ATOM 446 N1 A A 14 -16.307 -3.823 -6.473 1.00 1.00 N +ATOM 447 C2 A A 14 -17.634 -3.765 -6.450 1.00 1.00 C +ATOM 448 N3 A A 14 -18.456 -3.117 -7.261 1.00 1.00 N +ATOM 449 C4 A A 14 -17.756 -2.454 -8.206 1.00 1.00 C +ATOM 450 H5' A A 14 -19.715 -0.291 -13.273 1.00 1.00 H +ATOM 451 H5'' A A 14 -20.013 1.396 -12.806 1.00 1.00 H +ATOM 452 H4' A A 14 -21.393 -0.079 -11.455 1.00 1.00 H +ATOM 453 H3' A A 14 -19.143 1.341 -10.047 1.00 1.00 H +ATOM 454 H2' A A 14 -19.533 0.197 -8.053 1.00 1.00 H +ATOM 455 HO2' A A 14 -21.552 -0.964 -7.731 1.00 1.00 H +ATOM 456 H1' A A 14 -20.290 -2.253 -9.065 1.00 1.00 H +ATOM 457 H8 A A 14 -17.277 -0.563 -10.781 1.00 1.00 H +ATOM 458 H61 A A 14 -13.810 -3.749 -6.763 1.00 1.00 H +ATOM 459 H62 A A 14 -13.795 -2.707 -8.167 1.00 1.00 H +ATOM 460 H2 A A 14 -18.113 -4.331 -5.651 1.00 1.00 H +ATOM 461 P C A 15 -20.927 3.266 -9.261 1.00 1.00 P +ATOM 462 OP1 C A 15 -22.166 4.063 -9.406 1.00 1.00 O +ATOM 463 OP2 C A 15 -19.645 3.798 -9.779 1.00 1.00 O +ATOM 464 O5' C A 15 -20.734 2.920 -7.700 1.00 1.00 O +ATOM 465 C5' C A 15 -21.868 2.711 -6.855 1.00 1.00 C +ATOM 466 C4' C A 15 -21.447 2.288 -5.450 1.00 1.00 C +ATOM 467 O4' C A 15 -20.682 1.089 -5.510 1.00 1.00 O +ATOM 468 C3' C A 15 -20.583 3.303 -4.722 1.00 1.00 C +ATOM 469 O3' C A 15 -21.414 4.229 -4.008 1.00 1.00 O +ATOM 470 C2' C A 15 -19.784 2.448 -3.749 1.00 1.00 C +ATOM 471 O2' C A 15 -20.410 2.397 -2.461 1.00 1.00 O +ATOM 472 C1' C A 15 -19.755 1.069 -4.413 1.00 1.00 C +ATOM 473 N1 C A 15 -18.431 0.692 -4.955 1.00 1.00 N +ATOM 474 C2 C A 15 -17.628 -0.133 -4.181 1.00 1.00 C +ATOM 475 O2 C A 15 -18.028 -0.534 -3.091 1.00 1.00 O +ATOM 476 N3 C A 15 -16.402 -0.479 -4.665 1.00 1.00 N +ATOM 477 C4 C A 15 -15.983 -0.034 -5.858 1.00 1.00 C +ATOM 478 N4 C A 15 -14.777 -0.389 -6.303 1.00 1.00 N +ATOM 479 C5 C A 15 -16.809 0.816 -6.658 1.00 1.00 C +ATOM 480 C6 C A 15 -18.019 1.153 -6.171 1.00 1.00 C +ATOM 481 H5' C A 15 -22.499 1.935 -7.288 1.00 1.00 H +ATOM 482 H5'' C A 15 -22.438 3.638 -6.790 1.00 1.00 H +ATOM 483 H4' C A 15 -22.339 2.096 -4.858 1.00 1.00 H +ATOM 484 H3' C A 15 -19.922 3.820 -5.420 1.00 1.00 H +ATOM 485 H2' C A 15 -18.770 2.833 -3.668 1.00 1.00 H +ATOM 486 HO2' C A 15 -20.976 1.622 -2.450 1.00 1.00 H +ATOM 487 H1' C A 15 -20.074 0.321 -3.690 1.00 1.00 H +ATOM 488 H41 C A 15 -14.196 -0.986 -5.745 1.00 1.00 H +ATOM 489 H42 C A 15 -14.452 -0.061 -7.199 1.00 1.00 H +ATOM 490 H5 C A 15 -16.471 1.179 -7.630 1.00 1.00 H +ATOM 491 H6 C A 15 -18.675 1.800 -6.755 1.00 1.00 H +ATOM 492 P C A 16 -20.845 5.669 -3.558 1.00 1.00 P +ATOM 493 OP1 C A 16 -21.956 6.442 -2.957 1.00 1.00 O +ATOM 494 OP2 C A 16 -20.074 6.238 -4.686 1.00 1.00 O +ATOM 495 O5' C A 16 -19.811 5.278 -2.388 1.00 1.00 O +ATOM 496 C5' C A 16 -20.282 4.648 -1.198 1.00 1.00 C +ATOM 497 C4' C A 16 -19.162 3.907 -0.469 1.00 1.00 C +ATOM 498 O4' C A 16 -18.473 3.057 -1.385 1.00 1.00 O +ATOM 499 C3' C A 16 -18.101 4.803 0.153 1.00 1.00 C +ATOM 500 O3' C A 16 -18.438 5.064 1.519 1.00 1.00 O +ATOM 501 C2' C A 16 -16.839 3.958 0.117 1.00 1.00 C +ATOM 502 O2' C A 16 -16.586 3.347 1.385 1.00 1.00 O +ATOM 503 C1' C A 16 -17.109 2.912 -0.957 1.00 1.00 C +ATOM 504 N1 C A 16 -16.209 3.009 -2.133 1.00 1.00 N +ATOM 505 C2 C A 16 -15.092 2.187 -2.134 1.00 1.00 C +ATOM 506 O2 C A 16 -14.877 1.441 -1.180 1.00 1.00 O +ATOM 507 N3 C A 16 -14.256 2.235 -3.206 1.00 1.00 N +ATOM 508 C4 C A 16 -14.503 3.055 -4.235 1.00 1.00 C +ATOM 509 N4 C A 16 -13.663 3.076 -5.270 1.00 1.00 N +ATOM 510 C5 C A 16 -15.652 3.907 -4.238 1.00 1.00 C +ATOM 511 C6 C A 16 -16.475 3.852 -3.172 1.00 1.00 C +ATOM 512 H5' C A 16 -21.069 3.939 -1.458 1.00 1.00 H +ATOM 513 H5'' C A 16 -20.694 5.408 -0.534 1.00 1.00 H +ATOM 514 H4' C A 16 -19.601 3.288 0.312 1.00 1.00 H +ATOM 515 H3' C A 16 -17.979 5.725 -0.415 1.00 1.00 H +ATOM 516 H2' C A 16 -15.992 4.582 -0.184 1.00 1.00 H +ATOM 517 HO2' C A 16 -16.699 2.401 1.273 1.00 1.00 H +ATOM 518 H1' C A 16 -16.997 1.922 -0.508 1.00 1.00 H +ATOM 519 H41 C A 16 -12.846 2.476 -5.273 1.00 1.00 H +ATOM 520 H42 C A 16 -13.839 3.690 -6.052 1.00 1.00 H +ATOM 521 H5 C A 16 -15.855 4.575 -5.076 1.00 1.00 H +ATOM 522 H6 C A 16 -17.358 4.490 -3.139 1.00 1.00 H +ATOM 523 P G A 17 -17.581 6.111 2.392 1.00 1.00 P +ATOM 524 OP1 G A 17 -18.459 6.662 3.449 1.00 1.00 O +ATOM 525 OP2 G A 17 -16.880 7.026 1.464 1.00 1.00 O +ATOM 526 O5' G A 17 -16.477 5.169 3.098 1.00 1.00 O +ATOM 527 C5' G A 17 -16.868 4.193 4.073 1.00 1.00 C +ATOM 528 C4' G A 17 -15.660 3.492 4.692 1.00 1.00 C +ATOM 529 O4' G A 17 -15.048 2.627 3.735 1.00 1.00 O +ATOM 530 C3' G A 17 -14.576 4.439 5.182 1.00 1.00 C +ATOM 531 O3' G A 17 -14.783 4.751 6.563 1.00 1.00 O +ATOM 532 C2' G A 17 -13.299 3.636 5.024 1.00 1.00 C +ATOM 533 O2' G A 17 -12.969 2.934 6.224 1.00 1.00 O +ATOM 534 C1' G A 17 -13.621 2.670 3.894 1.00 1.00 C +ATOM 535 N9 G A 17 -13.047 3.074 2.607 1.00 1.00 N +ATOM 536 C8 G A 17 -13.683 3.662 1.544 1.00 1.00 C +ATOM 537 N7 G A 17 -12.899 3.916 0.534 1.00 1.00 N +ATOM 538 C5 G A 17 -11.652 3.465 0.954 1.00 1.00 C +ATOM 539 C6 G A 17 -10.403 3.480 0.275 1.00 1.00 C +ATOM 540 O6 G A 17 -10.151 3.902 -0.851 1.00 1.00 O +ATOM 541 N1 G A 17 -9.394 2.930 1.055 1.00 1.00 N +ATOM 542 C2 G A 17 -9.560 2.429 2.328 1.00 1.00 C +ATOM 543 N2 G A 17 -8.467 1.946 2.917 1.00 1.00 N +ATOM 544 N3 G A 17 -10.734 2.413 2.968 1.00 1.00 N +ATOM 545 C4 G A 17 -11.732 2.947 2.223 1.00 1.00 C +ATOM 546 H5' G A 17 -17.503 3.448 3.594 1.00 1.00 H +ATOM 547 H5'' G A 17 -17.434 4.686 4.863 1.00 1.00 H +ATOM 548 H4' G A 17 -16.001 2.886 5.530 1.00 1.00 H +ATOM 549 H3' G A 17 -14.547 5.343 4.569 1.00 1.00 H +ATOM 550 H2' G A 17 -12.483 4.293 4.723 1.00 1.00 H +ATOM 551 HO2' G A 17 -12.255 2.332 6.011 1.00 1.00 H +ATOM 552 H1' G A 17 -13.256 1.677 4.151 1.00 1.00 H +ATOM 553 H8 G A 17 -14.748 3.895 1.543 1.00 1.00 H +ATOM 554 H1 G A 17 -8.474 2.907 0.637 1.00 1.00 H +ATOM 555 H21 G A 17 -7.583 1.958 2.431 1.00 1.00 H +ATOM 556 H22 G A 17 -8.525 1.565 3.850 1.00 1.00 H +ATOM 557 P G A 18 -14.083 6.044 7.223 1.00 1.00 P +ATOM 558 OP1 G A 18 -14.521 6.137 8.633 1.00 1.00 O +ATOM 559 OP2 G A 18 -14.280 7.193 6.312 1.00 1.00 O +ATOM 560 O5' G A 18 -12.522 5.647 7.205 1.00 1.00 O +ATOM 561 C5' G A 18 -12.045 4.536 7.971 1.00 1.00 C +ATOM 562 C4' G A 18 -10.548 4.309 7.770 1.00 1.00 C +ATOM 563 O4' G A 18 -10.284 4.001 6.403 1.00 1.00 O +ATOM 564 C3' G A 18 -9.686 5.509 8.121 1.00 1.00 C +ATOM 565 O3' G A 18 -9.255 5.407 9.483 1.00 1.00 O +ATOM 566 C2' G A 18 -8.490 5.384 7.189 1.00 1.00 C +ATOM 567 O2' G A 18 -7.391 4.730 7.831 1.00 1.00 O +ATOM 568 C1' G A 18 -9.022 4.565 6.018 1.00 1.00 C +ATOM 569 N9 G A 18 -9.244 5.360 4.799 1.00 1.00 N +ATOM 570 C8 G A 18 -10.354 6.081 4.442 1.00 1.00 C +ATOM 571 N7 G A 18 -10.246 6.683 3.290 1.00 1.00 N +ATOM 572 C5 G A 18 -8.972 6.339 2.850 1.00 1.00 C +ATOM 573 C6 G A 18 -8.293 6.701 1.653 1.00 1.00 C +ATOM 574 O6 G A 18 -8.694 7.411 0.733 1.00 1.00 O +ATOM 575 N1 G A 18 -7.024 6.140 1.596 1.00 1.00 N +ATOM 576 C2 G A 18 -6.474 5.332 2.568 1.00 1.00 C +ATOM 577 N2 G A 18 -5.239 4.888 2.336 1.00 1.00 N +ATOM 578 N3 G A 18 -7.110 4.990 3.694 1.00 1.00 N +ATOM 579 C4 G A 18 -8.350 5.528 3.767 1.00 1.00 C +ATOM 580 H5' G A 18 -12.584 3.639 7.670 1.00 1.00 H +ATOM 581 H5'' G A 18 -12.235 4.727 9.028 1.00 1.00 H +ATOM 582 H4' G A 18 -10.236 3.462 8.377 1.00 1.00 H +ATOM 583 H3' G A 18 -10.225 6.442 7.943 1.00 1.00 H +ATOM 584 H2' G A 18 -8.194 6.371 6.836 1.00 1.00 H +ATOM 585 HO2' G A 18 -7.697 3.865 8.110 1.00 1.00 H +ATOM 586 H1' G A 18 -8.322 3.760 5.794 1.00 1.00 H +ATOM 587 H8 G A 18 -11.247 6.143 5.064 1.00 1.00 H +ATOM 588 H1 G A 18 -6.480 6.354 0.773 1.00 1.00 H +ATOM 589 H21 G A 18 -4.761 5.148 1.484 1.00 1.00 H +ATOM 590 H22 G A 18 -4.781 4.291 3.010 1.00 1.00 H +ATOM 591 P G A 19 -8.811 6.720 10.305 1.00 1.00 P +ATOM 592 OP1 G A 19 -8.503 6.313 11.694 1.00 1.00 O +ATOM 593 OP2 G A 19 -9.808 7.784 10.053 1.00 1.00 O +ATOM 594 O5' G A 19 -7.433 7.137 9.583 1.00 1.00 O +ATOM 595 C5' G A 19 -6.280 6.294 9.669 1.00 1.00 C +ATOM 596 C4' G A 19 -5.114 6.858 8.861 1.00 1.00 C +ATOM 597 O4' G A 19 -5.416 6.807 7.471 1.00 1.00 O +ATOM 598 C3' G A 19 -4.783 8.306 9.184 1.00 1.00 C +ATOM 599 O3' G A 19 -3.775 8.349 10.202 1.00 1.00 O +ATOM 600 C2' G A 19 -4.227 8.854 7.875 1.00 1.00 C +ATOM 601 O2' G A 19 -2.795 8.838 7.873 1.00 1.00 O +ATOM 602 C1' G A 19 -4.797 7.917 6.807 1.00 1.00 C +ATOM 603 N9 G A 19 -5.817 8.541 5.943 1.00 1.00 N +ATOM 604 C8 G A 19 -7.143 8.769 6.205 1.00 1.00 C +ATOM 605 N7 G A 19 -7.784 9.346 5.228 1.00 1.00 N +ATOM 606 C5 G A 19 -6.815 9.515 4.244 1.00 1.00 C +ATOM 607 C6 G A 19 -6.924 10.091 2.947 1.00 1.00 C +ATOM 608 O6 G A 19 -7.916 10.573 2.407 1.00 1.00 O +ATOM 609 N1 G A 19 -5.709 10.066 2.275 1.00 1.00 N +ATOM 610 C2 G A 19 -4.534 9.552 2.783 1.00 1.00 C +ATOM 611 N2 G A 19 -3.469 9.618 1.986 1.00 1.00 N +ATOM 612 N3 G A 19 -4.429 9.010 4.002 1.00 1.00 N +ATOM 613 C4 G A 19 -5.606 9.025 4.672 1.00 1.00 C +ATOM 614 H5' G A 19 -6.532 5.304 9.287 1.00 1.00 H +ATOM 615 H5'' G A 19 -5.981 6.208 10.713 1.00 1.00 H +ATOM 616 H4' G A 19 -4.231 6.246 9.044 1.00 1.00 H +ATOM 617 H3' G A 19 -5.678 8.852 9.486 1.00 1.00 H +ATOM 618 H2' G A 19 -4.599 9.869 7.713 1.00 1.00 H +ATOM 619 HO2' G A 19 -2.502 9.322 8.649 1.00 1.00 H +ATOM 620 H1' G A 19 -3.984 7.550 6.181 1.00 1.00 H +ATOM 621 H8 G A 19 -7.619 8.492 7.146 1.00 1.00 H +ATOM 622 H1 G A 19 -5.707 10.460 1.346 1.00 1.00 H +ATOM 623 H21 G A 19 -3.550 10.029 1.066 1.00 1.00 H +ATOM 624 H22 G A 19 -2.579 9.259 2.302 1.00 1.00 H +ATOM 625 P G A 20 -3.685 9.595 11.217 1.00 1.00 P +ATOM 626 OP1 G A 20 -2.417 9.486 11.972 1.00 1.00 O +ATOM 627 OP2 G A 20 -4.970 9.693 11.946 1.00 1.00 O +ATOM 628 O5' G A 20 -3.571 10.854 10.222 1.00 1.00 O +ATOM 629 C5' G A 20 -4.272 12.067 10.508 1.00 1.00 C +ATOM 630 C4' G A 20 -4.056 13.112 9.418 1.00 1.00 C +ATOM 631 O4' G A 20 -4.219 12.511 8.132 1.00 1.00 O +ATOM 632 C3' G A 20 -5.017 14.291 9.500 1.00 1.00 C +ATOM 633 O3' G A 20 -4.372 15.385 10.159 1.00 1.00 O +ATOM 634 C2' G A 20 -5.289 14.649 8.048 1.00 1.00 C +ATOM 635 O2' G A 20 -4.402 15.675 7.590 1.00 1.00 O +ATOM 636 C1' G A 20 -5.051 13.336 7.308 1.00 1.00 C +ATOM 637 N9 G A 20 -6.281 12.575 7.034 1.00 1.00 N +ATOM 638 C8 G A 20 -6.830 11.554 7.767 1.00 1.00 C +ATOM 639 N7 G A 20 -7.938 11.082 7.270 1.00 1.00 N +ATOM 640 C5 G A 20 -8.142 11.842 6.123 1.00 1.00 C +ATOM 641 C6 G A 20 -9.193 11.781 5.167 1.00 1.00 C +ATOM 642 O6 G A 20 -10.169 11.032 5.153 1.00 1.00 O +ATOM 643 N1 G A 20 -9.023 12.721 4.161 1.00 1.00 N +ATOM 644 C2 G A 20 -7.973 13.610 4.079 1.00 1.00 C +ATOM 645 N2 G A 20 -7.985 14.436 3.032 1.00 1.00 N +ATOM 646 N3 G A 20 -6.982 13.671 4.976 1.00 1.00 N +ATOM 647 C4 G A 20 -7.132 12.760 5.967 1.00 1.00 C +ATOM 648 H5' G A 20 -3.917 12.466 11.458 1.00 1.00 H +ATOM 649 H5'' G A 20 -5.337 11.853 10.590 1.00 1.00 H +ATOM 650 H4' G A 20 -3.037 13.487 9.494 1.00 1.00 H +ATOM 651 H3' G A 20 -5.939 14.006 10.010 1.00 1.00 H +ATOM 652 H2' G A 20 -6.331 14.958 7.931 1.00 1.00 H +ATOM 653 HO2' G A 20 -4.927 16.301 7.084 1.00 1.00 H +ATOM 654 H1' G A 20 -4.541 13.539 6.368 1.00 1.00 H +ATOM 655 H8 G A 20 -6.380 11.170 8.681 1.00 1.00 H +ATOM 656 H1 G A 20 -9.734 12.738 3.444 1.00 1.00 H +ATOM 657 H21 G A 20 -8.736 14.386 2.358 1.00 1.00 H +ATOM 658 H22 G A 20 -7.246 15.110 2.915 1.00 1.00 H +ATOM 659 P A A 21 -5.195 16.345 11.156 1.00 1.00 P +ATOM 660 OP1 A A 21 -4.222 17.149 11.930 1.00 1.00 O +ATOM 661 OP2 A A 21 -6.203 15.525 11.862 1.00 1.00 O +ATOM 662 O5' A A 21 -5.967 17.329 10.141 1.00 1.00 O +ATOM 663 C5' A A 21 -7.223 17.910 10.502 1.00 1.00 C +ATOM 664 C4' A A 21 -7.671 18.948 9.477 1.00 1.00 C +ATOM 665 O4' A A 21 -6.798 20.083 9.532 1.00 1.00 O +ATOM 666 C3' A A 21 -7.669 18.429 8.043 1.00 1.00 C +ATOM 667 O3' A A 21 -9.015 18.149 7.635 1.00 1.00 O +ATOM 668 C2' A A 21 -7.114 19.588 7.226 1.00 1.00 C +ATOM 669 O2' A A 21 -8.163 20.401 6.691 1.00 1.00 O +ATOM 670 C1' A A 21 -6.272 20.358 8.230 1.00 1.00 C +ATOM 671 N9 A A 21 -4.847 19.974 8.235 1.00 1.00 N +ATOM 672 C8 A A 21 -4.204 19.115 9.088 1.00 1.00 C +ATOM 673 N7 A A 21 -2.932 18.972 8.833 1.00 1.00 N +ATOM 674 C5 A A 21 -2.720 19.796 7.732 1.00 1.00 C +ATOM 675 C6 A A 21 -1.575 20.090 6.972 1.00 1.00 C +ATOM 676 N6 A A 21 -0.377 19.561 7.221 1.00 1.00 N +ATOM 677 N1 A A 21 -1.719 20.949 5.950 1.00 1.00 N +ATOM 678 C2 A A 21 -2.915 21.473 5.706 1.00 1.00 C +ATOM 679 N3 A A 21 -4.058 21.275 6.343 1.00 1.00 N +ATOM 680 C4 A A 21 -3.882 20.409 7.363 1.00 1.00 C +ATOM 681 H5' A A 21 -7.127 18.389 11.476 1.00 1.00 H +ATOM 682 H5'' A A 21 -7.975 17.123 10.564 1.00 1.00 H +ATOM 683 H4' A A 21 -8.677 19.277 9.731 1.00 1.00 H +ATOM 684 H3' A A 21 -7.034 17.545 7.948 1.00 1.00 H +ATOM 685 H2' A A 21 -6.477 19.208 6.429 1.00 1.00 H +ATOM 686 HO2' A A 21 -8.946 19.850 6.628 1.00 1.00 H +ATOM 687 H1' A A 21 -6.352 21.426 8.027 1.00 1.00 H +ATOM 688 H8 A A 21 -4.710 18.599 9.906 1.00 1.00 H +ATOM 689 H61 A A 21 0.413 19.808 6.642 1.00 1.00 H +ATOM 690 H62 A A 21 -0.260 18.915 7.987 1.00 1.00 H +ATOM 691 H2 A A 21 -2.961 22.162 4.863 1.00 1.00 H +ATOM 692 P A A 22 -9.341 16.877 6.699 1.00 1.00 P +ATOM 693 OP1 A A 22 -10.805 16.816 6.496 1.00 1.00 O +ATOM 694 OP2 A A 22 -8.622 15.704 7.245 1.00 1.00 O +ATOM 695 O5' A A 22 -8.657 17.284 5.301 1.00 1.00 O +ATOM 696 C5' A A 22 -9.369 18.084 4.352 1.00 1.00 C +ATOM 697 C4' A A 22 -8.467 19.142 3.725 1.00 1.00 C +ATOM 698 O4' A A 22 -7.375 19.403 4.606 1.00 1.00 O +ATOM 699 C3' A A 22 -7.878 18.742 2.373 1.00 1.00 C +ATOM 700 O3' A A 22 -8.633 19.349 1.320 1.00 1.00 O +ATOM 701 C2' A A 22 -6.479 19.328 2.396 1.00 1.00 C +ATOM 702 O2' A A 22 -6.450 20.634 1.812 1.00 1.00 O +ATOM 703 C1' A A 22 -6.144 19.362 3.879 1.00 1.00 C +ATOM 704 N9 A A 22 -5.395 18.182 4.333 1.00 1.00 N +ATOM 705 C8 A A 22 -5.817 17.134 5.111 1.00 1.00 C +ATOM 706 N7 A A 22 -4.888 16.251 5.357 1.00 1.00 N +ATOM 707 C5 A A 22 -3.771 16.749 4.694 1.00 1.00 C +ATOM 708 C6 A A 22 -2.455 16.275 4.565 1.00 1.00 C +ATOM 709 N6 A A 22 -2.029 15.143 5.124 1.00 1.00 N +ATOM 710 N1 A A 22 -1.602 17.017 3.837 1.00 1.00 N +ATOM 711 C2 A A 22 -2.034 18.143 3.283 1.00 1.00 C +ATOM 712 N3 A A 22 -3.239 18.691 3.332 1.00 1.00 N +ATOM 713 C4 A A 22 -4.071 17.925 4.068 1.00 1.00 C +ATOM 714 H5' A A 22 -10.202 18.576 4.857 1.00 1.00 H +ATOM 715 H5'' A A 22 -9.761 17.438 3.567 1.00 1.00 H +ATOM 716 H4' A A 22 -9.034 20.062 3.603 1.00 1.00 H +ATOM 717 H3' A A 22 -7.845 17.657 2.266 1.00 1.00 H +ATOM 718 H2' A A 22 -5.789 18.659 1.877 1.00 1.00 H +ATOM 719 HO2' A A 22 -6.564 20.523 0.863 1.00 1.00 H +ATOM 720 H1' A A 22 -5.565 20.258 4.104 1.00 1.00 H +ATOM 721 H8 A A 22 -6.836 17.046 5.489 1.00 1.00 H +ATOM 722 H61 A A 22 -1.071 14.846 4.999 1.00 1.00 H +ATOM 723 H62 A A 22 -2.663 14.581 5.671 1.00 1.00 H +ATOM 724 H2 A A 22 -1.292 18.696 2.705 1.00 1.00 H +ATOM 725 P A A 23 -9.017 18.512 -0.001 1.00 1.00 P +ATOM 726 OP1 A A 23 -9.716 19.420 -0.936 1.00 1.00 O +ATOM 727 OP2 A A 23 -9.663 17.250 0.423 1.00 1.00 O +ATOM 728 O5' A A 23 -7.578 18.154 -0.633 1.00 1.00 O +ATOM 729 C5' A A 23 -6.936 19.051 -1.546 1.00 1.00 C +ATOM 730 C4' A A 23 -5.475 18.671 -1.762 1.00 1.00 C +ATOM 731 O4' A A 23 -4.819 18.551 -0.500 1.00 1.00 O +ATOM 732 C3' A A 23 -5.280 17.349 -2.489 1.00 1.00 C +ATOM 733 O3' A A 23 -5.137 17.584 -3.894 1.00 1.00 O +ATOM 734 C2' A A 23 -3.979 16.811 -1.914 1.00 1.00 C +ATOM 735 O2' A A 23 -2.853 17.199 -2.707 1.00 1.00 O +ATOM 736 C1' A A 23 -3.922 17.432 -0.524 1.00 1.00 C +ATOM 737 N9 A A 23 -4.332 16.508 0.545 1.00 1.00 N +ATOM 738 C8 A A 23 -5.592 16.249 1.018 1.00 1.00 C +ATOM 739 N7 A A 23 -5.625 15.365 1.977 1.00 1.00 N +ATOM 740 C5 A A 23 -4.289 15.016 2.153 1.00 1.00 C +ATOM 741 C6 A A 23 -3.648 14.117 3.023 1.00 1.00 C +ATOM 742 N6 A A 23 -4.298 13.373 3.919 1.00 1.00 N +ATOM 743 N1 A A 23 -2.312 14.019 2.930 1.00 1.00 N +ATOM 744 C2 A A 23 -1.668 14.759 2.036 1.00 1.00 C +ATOM 745 N3 A A 23 -2.155 15.630 1.167 1.00 1.00 N +ATOM 746 C4 A A 23 -3.496 15.708 1.285 1.00 1.00 C +ATOM 747 H5' A A 23 -6.988 20.065 -1.149 1.00 1.00 H +ATOM 748 H5'' A A 23 -7.457 19.015 -2.502 1.00 1.00 H +ATOM 749 H4' A A 23 -4.988 19.461 -2.330 1.00 1.00 H +ATOM 750 H3' A A 23 -6.108 16.667 -2.281 1.00 1.00 H +ATOM 751 H2' A A 23 -4.033 15.724 -1.828 1.00 1.00 H +ATOM 752 HO2' A A 23 -2.240 16.463 -2.710 1.00 1.00 H +ATOM 753 H1' A A 23 -2.910 17.782 -0.325 1.00 1.00 H +ATOM 754 H8 A A 23 -6.487 16.737 0.627 1.00 1.00 H +ATOM 755 H61 A A 23 -3.785 12.744 4.519 1.00 1.00 H +ATOM 756 H62 A A 23 -5.308 13.440 3.999 1.00 1.00 H +ATOM 757 H2 A A 23 -0.587 14.628 2.014 1.00 1.00 H +ATOM 758 P C A 24 -5.641 16.489 -4.962 1.00 1.00 P +ATOM 759 OP1 C A 24 -5.310 16.977 -6.319 1.00 1.00 O +ATOM 760 OP2 C A 24 -7.037 16.128 -4.629 1.00 1.00 O +ATOM 761 O5' C A 24 -4.701 15.221 -4.639 1.00 1.00 O +ATOM 762 C5' C A 24 -3.288 15.290 -4.845 1.00 1.00 C +ATOM 763 C4' C A 24 -2.547 14.296 -3.956 1.00 1.00 C +ATOM 764 O4' C A 24 -2.960 14.466 -2.602 1.00 1.00 O +ATOM 765 C3' C A 24 -2.794 12.836 -4.303 1.00 1.00 C +ATOM 766 O3' C A 24 -1.801 12.381 -5.226 1.00 1.00 O +ATOM 767 C2' C A 24 -2.623 12.125 -2.972 1.00 1.00 C +ATOM 768 O2' C A 24 -1.273 11.686 -2.782 1.00 1.00 O +ATOM 769 C1' C A 24 -3.010 13.190 -1.951 1.00 1.00 C +ATOM 770 N1 C A 24 -4.372 13.018 -1.411 1.00 1.00 N +ATOM 771 C2 C A 24 -4.509 12.300 -0.233 1.00 1.00 C +ATOM 772 O2 C A 24 -3.518 11.831 0.321 1.00 1.00 O +ATOM 773 N3 C A 24 -5.760 12.133 0.279 1.00 1.00 N +ATOM 774 C4 C A 24 -6.831 12.649 -0.340 1.00 1.00 C +ATOM 775 N4 C A 24 -8.042 12.468 0.187 1.00 1.00 N +ATOM 776 C5 C A 24 -6.692 13.390 -1.556 1.00 1.00 C +ATOM 777 C6 C A 24 -5.451 13.550 -2.054 1.00 1.00 C +ATOM 778 H5' C A 24 -2.942 16.299 -4.615 1.00 1.00 H +ATOM 779 H5'' C A 24 -3.068 15.066 -5.889 1.00 1.00 H +ATOM 780 H4' C A 24 -1.480 14.497 -4.015 1.00 1.00 H +ATOM 781 H3' C A 24 -3.804 12.693 -4.696 1.00 1.00 H +ATOM 782 H2' C A 24 -3.315 11.285 -2.907 1.00 1.00 H +ATOM 783 HO2' C A 24 -1.073 11.776 -1.848 1.00 1.00 H +ATOM 784 H1' C A 24 -2.292 13.179 -1.131 1.00 1.00 H +ATOM 785 H41 C A 24 -8.144 11.946 1.044 1.00 1.00 H +ATOM 786 H42 C A 24 -8.855 12.853 -0.272 1.00 1.00 H +ATOM 787 H5 C A 24 -7.561 13.811 -2.063 1.00 1.00 H +ATOM 788 H6 C A 24 -5.307 14.109 -2.978 1.00 1.00 H +ATOM 789 P U A 25 -2.089 11.119 -6.185 1.00 1.00 P +ATOM 790 OP1 U A 25 -0.900 10.906 -7.040 1.00 1.00 O +ATOM 791 OP2 U A 25 -3.420 11.303 -6.805 1.00 1.00 O +ATOM 792 O5' U A 25 -2.183 9.897 -5.141 1.00 1.00 O +ATOM 793 C5' U A 25 -1.055 9.534 -4.340 1.00 1.00 C +ATOM 794 C4' U A 25 -1.437 8.526 -3.260 1.00 1.00 C +ATOM 795 O4' U A 25 -2.406 9.094 -2.388 1.00 1.00 O +ATOM 796 C3' U A 25 -2.046 7.239 -3.790 1.00 1.00 C +ATOM 797 O3' U A 25 -1.016 6.275 -4.025 1.00 1.00 O +ATOM 798 C2' U A 25 -2.946 6.771 -2.656 1.00 1.00 C +ATOM 799 O2' U A 25 -2.283 5.807 -1.829 1.00 1.00 O +ATOM 800 C1' U A 25 -3.255 8.054 -1.881 1.00 1.00 C +ATOM 801 N1 U A 25 -4.654 8.515 -2.027 1.00 1.00 N +ATOM 802 C2 U A 25 -5.553 8.166 -1.037 1.00 1.00 C +ATOM 803 O2 U A 25 -5.225 7.498 -0.060 1.00 1.00 O +ATOM 804 N3 U A 25 -6.851 8.613 -1.210 1.00 1.00 N +ATOM 805 C4 U A 25 -7.320 9.367 -2.273 1.00 1.00 C +ATOM 806 O4 U A 25 -8.499 9.711 -2.325 1.00 1.00 O +ATOM 807 C5 U A 25 -6.312 9.685 -3.259 1.00 1.00 C +ATOM 808 C6 U A 25 -5.033 9.259 -3.111 1.00 1.00 C +ATOM 809 H5' U A 25 -0.651 10.429 -3.865 1.00 1.00 H +ATOM 810 H5'' U A 25 -0.290 9.095 -4.981 1.00 1.00 H +ATOM 811 H4' U A 25 -0.551 8.283 -2.676 1.00 1.00 H +ATOM 812 H3' U A 25 -2.628 7.429 -4.696 1.00 1.00 H +ATOM 813 H2' U A 25 -3.868 6.356 -3.066 1.00 1.00 H +ATOM 814 HO2' U A 25 -1.647 6.282 -1.290 1.00 1.00 H +ATOM 815 H1' U A 25 -3.034 7.898 -0.826 1.00 1.00 H +ATOM 816 H3 U A 25 -7.520 8.366 -0.496 1.00 1.00 H +ATOM 817 H5 U A 25 -6.583 10.276 -4.134 1.00 1.00 H +ATOM 818 H6 U A 25 -4.295 9.512 -3.870 1.00 1.00 H +ATOM 819 P U A 26 -1.335 4.925 -4.840 1.00 1.00 P +ATOM 820 OP1 U A 26 -0.053 4.333 -5.281 1.00 1.00 O +ATOM 821 OP2 U A 26 -2.391 5.224 -5.834 1.00 1.00 O +ATOM 822 O5' U A 26 -1.967 3.970 -3.707 1.00 1.00 O +ATOM 823 C5' U A 26 -1.180 3.541 -2.591 1.00 1.00 C +ATOM 824 C4' U A 26 -2.030 2.800 -1.563 1.00 1.00 C +ATOM 825 O4' U A 26 -2.964 3.694 -0.961 1.00 1.00 O +ATOM 826 C3' U A 26 -2.843 1.658 -2.139 1.00 1.00 C +ATOM 827 O3' U A 26 -2.077 0.445 -2.117 1.00 1.00 O +ATOM 828 C2' U A 26 -4.023 1.562 -1.185 1.00 1.00 C +ATOM 829 O2' U A 26 -3.782 0.636 -0.123 1.00 1.00 O +ATOM 830 C1' U A 26 -4.178 2.985 -0.660 1.00 1.00 C +ATOM 831 N1 U A 26 -5.285 3.714 -1.305 1.00 1.00 N +ATOM 832 C2 U A 26 -6.479 3.851 -0.623 1.00 1.00 C +ATOM 833 O2 U A 26 -6.650 3.378 0.498 1.00 1.00 O +ATOM 834 N3 U A 26 -7.476 4.552 -1.278 1.00 1.00 N +ATOM 835 C4 U A 26 -7.384 5.118 -2.539 1.00 1.00 C +ATOM 836 O4 U A 26 -8.338 5.723 -3.025 1.00 1.00 O +ATOM 837 C5 U A 26 -6.102 4.926 -3.177 1.00 1.00 C +ATOM 838 C6 U A 26 -5.110 4.244 -2.556 1.00 1.00 C +ATOM 839 H5' U A 26 -0.728 4.412 -2.117 1.00 1.00 H +ATOM 840 H5'' U A 26 -0.390 2.878 -2.943 1.00 1.00 H +ATOM 841 H4' U A 26 -1.377 2.413 -0.783 1.00 1.00 H +ATOM 842 H3' U A 26 -3.181 1.896 -3.150 1.00 1.00 H +ATOM 843 H2' U A 26 -4.915 1.295 -1.738 1.00 1.00 H +ATOM 844 HO2' U A 26 -4.622 0.484 0.316 1.00 1.00 H +ATOM 845 H1' U A 26 -4.328 2.965 0.418 1.00 1.00 H +ATOM 846 H3 U A 26 -8.356 4.659 -0.791 1.00 1.00 H +ATOM 847 H5 U A 26 -5.931 5.332 -4.174 1.00 1.00 H +ATOM 848 H6 U A 26 -4.151 4.116 -3.059 1.00 1.00 H +ATOM 849 P G A 27 -2.435 -0.773 -3.113 1.00 1.00 P +ATOM 850 OP1 G A 27 -1.423 -1.838 -2.929 1.00 1.00 O +ATOM 851 OP2 G A 27 -2.680 -0.215 -4.462 1.00 1.00 O +ATOM 852 O5' G A 27 -3.838 -1.302 -2.526 1.00 1.00 O +ATOM 853 C5' G A 27 -3.942 -1.684 -1.153 1.00 1.00 C +ATOM 854 C4' G A 27 -5.389 -1.665 -0.665 1.00 1.00 C +ATOM 855 O4' G A 27 -6.008 -0.419 -1.001 1.00 1.00 O +ATOM 856 C3' G A 27 -6.276 -2.744 -1.267 1.00 1.00 C +ATOM 857 O3' G A 27 -6.241 -3.906 -0.425 1.00 1.00 O +ATOM 858 C2' G A 27 -7.668 -2.134 -1.217 1.00 1.00 C +ATOM 859 O2' G A 27 -8.409 -2.619 -0.093 1.00 1.00 O +ATOM 860 C1' G A 27 -7.422 -0.632 -1.120 1.00 1.00 C +ATOM 861 N9 G A 27 -7.967 0.140 -2.259 1.00 1.00 N +ATOM 862 C8 G A 27 -7.317 0.798 -3.273 1.00 1.00 C +ATOM 863 N7 G A 27 -8.115 1.421 -4.095 1.00 1.00 N +ATOM 864 C5 G A 27 -9.386 1.156 -3.593 1.00 1.00 C +ATOM 865 C6 G A 27 -10.660 1.571 -4.069 1.00 1.00 C +ATOM 866 O6 G A 27 -10.920 2.272 -5.044 1.00 1.00 O +ATOM 867 N1 G A 27 -11.687 1.082 -3.271 1.00 1.00 N +ATOM 868 C2 G A 27 -11.512 0.293 -2.154 1.00 1.00 C +ATOM 869 N2 G A 27 -12.619 -0.085 -1.518 1.00 1.00 N +ATOM 870 N3 G A 27 -10.315 -0.096 -1.704 1.00 1.00 N +ATOM 871 C4 G A 27 -9.304 0.371 -2.470 1.00 1.00 C +ATOM 872 H5' G A 27 -3.352 -0.995 -0.546 1.00 1.00 H +ATOM 873 H5'' G A 27 -3.543 -2.690 -1.035 1.00 1.00 H +ATOM 874 H4' G A 27 -5.394 -1.770 0.419 1.00 1.00 H +ATOM 875 H3' G A 27 -5.978 -2.978 -2.290 1.00 1.00 H +ATOM 876 H2' G A 27 -8.196 -2.360 -2.150 1.00 1.00 H +ATOM 877 HO2' G A 27 -7.837 -3.222 0.388 1.00 1.00 H +ATOM 878 H1' G A 27 -7.895 -0.266 -0.211 1.00 1.00 H +ATOM 879 H8 G A 27 -6.233 0.795 -3.384 1.00 1.00 H +ATOM 880 H1 G A 27 -12.624 1.337 -3.545 1.00 1.00 H +ATOM 881 H21 G A 27 -13.525 0.211 -1.860 1.00 1.00 H +ATOM 882 H22 G A 27 -12.555 -0.664 -0.694 1.00 1.00 H +ATOM 883 P G A 28 -6.935 -5.286 -0.884 1.00 1.00 P +ATOM 884 OP1 G A 28 -6.234 -6.402 -0.211 1.00 1.00 O +ATOM 885 OP2 G A 28 -7.057 -5.275 -2.358 1.00 1.00 O +ATOM 886 O5' G A 28 -8.418 -5.174 -0.256 1.00 1.00 O +ATOM 887 C5' G A 28 -8.654 -5.436 1.135 1.00 1.00 C +ATOM 888 C4' G A 28 -10.149 -5.476 1.451 1.00 1.00 C +ATOM 889 O4' G A 28 -10.720 -4.175 1.284 1.00 1.00 O +ATOM 890 C3' G A 28 -10.937 -6.424 0.560 1.00 1.00 C +ATOM 891 O3' G A 28 -11.059 -7.703 1.195 1.00 1.00 O +ATOM 892 C2' G A 28 -12.296 -5.762 0.444 1.00 1.00 C +ATOM 893 O2' G A 28 -13.193 -6.209 1.464 1.00 1.00 O +ATOM 894 C1' G A 28 -11.971 -4.284 0.589 1.00 1.00 C +ATOM 895 N9 G A 28 -11.816 -3.591 -0.696 1.00 1.00 N +ATOM 896 C8 G A 28 -10.662 -3.336 -1.390 1.00 1.00 C +ATOM 897 N7 G A 28 -10.849 -2.700 -2.512 1.00 1.00 N +ATOM 898 C5 G A 28 -12.227 -2.517 -2.570 1.00 1.00 C +ATOM 899 C6 G A 28 -13.021 -1.885 -3.566 1.00 1.00 C +ATOM 900 O6 G A 28 -12.652 -1.356 -4.613 1.00 1.00 O +ATOM 901 N1 G A 28 -14.368 -1.917 -3.239 1.00 1.00 N +ATOM 902 C2 G A 28 -14.893 -2.485 -2.098 1.00 1.00 C +ATOM 903 N2 G A 28 -16.215 -2.417 -1.962 1.00 1.00 N +ATOM 904 N3 G A 28 -14.150 -3.081 -1.159 1.00 1.00 N +ATOM 905 C4 G A 28 -12.830 -3.059 -1.461 1.00 1.00 C +ATOM 906 H5' G A 28 -8.184 -4.655 1.732 1.00 1.00 H +ATOM 907 H5'' G A 28 -8.211 -6.398 1.395 1.00 1.00 H +ATOM 908 H4' G A 28 -10.279 -5.775 2.489 1.00 1.00 H +ATOM 909 H3' G A 28 -10.465 -6.512 -0.421 1.00 1.00 H +ATOM 910 H2' G A 28 -12.713 -5.944 -0.546 1.00 1.00 H +ATOM 911 HO2' G A 28 -13.989 -6.522 1.026 1.00 1.00 H +ATOM 912 H1' G A 28 -12.751 -3.793 1.169 1.00 1.00 H +ATOM 913 H8 G A 28 -9.677 -3.634 -1.033 1.00 1.00 H +ATOM 914 H1 G A 28 -14.997 -1.486 -3.902 1.00 1.00 H +ATOM 915 H21 G A 28 -16.774 -1.968 -2.673 1.00 1.00 H +ATOM 916 H22 G A 28 -16.660 -2.816 -1.148 1.00 1.00 H +ATOM 917 P U A 29 -11.307 -9.033 0.319 1.00 1.00 P +ATOM 918 OP1 U A 29 -11.195 -10.203 1.216 1.00 1.00 O +ATOM 919 OP2 U A 29 -10.463 -8.951 -0.895 1.00 1.00 O +ATOM 920 O5' U A 29 -12.848 -8.889 -0.129 1.00 1.00 O +ATOM 921 C5' U A 29 -13.905 -9.246 0.769 1.00 1.00 C +ATOM 922 C4' U A 29 -15.275 -9.039 0.132 1.00 1.00 C +ATOM 923 O4' U A 29 -15.407 -7.689 -0.298 1.00 1.00 O +ATOM 924 C3' U A 29 -15.533 -9.901 -1.092 1.00 1.00 C +ATOM 925 O3' U A 29 -16.108 -11.153 -0.698 1.00 1.00 O +ATOM 926 C2' U A 29 -16.538 -9.079 -1.882 1.00 1.00 C +ATOM 927 O2' U A 29 -17.886 -9.409 -1.537 1.00 1.00 O +ATOM 928 C1' U A 29 -16.197 -7.643 -1.495 1.00 1.00 C +ATOM 929 N1 U A 29 -15.399 -6.936 -2.511 1.00 1.00 N +ATOM 930 C2 U A 29 -16.066 -6.182 -3.459 1.00 1.00 C +ATOM 931 O2 U A 29 -17.292 -6.096 -3.481 1.00 1.00 O +ATOM 932 N3 U A 29 -15.272 -5.527 -4.384 1.00 1.00 N +ATOM 933 C4 U A 29 -13.889 -5.562 -4.443 1.00 1.00 C +ATOM 934 O4 U A 29 -13.283 -4.940 -5.312 1.00 1.00 O +ATOM 935 C5 U A 29 -13.277 -6.374 -3.415 1.00 1.00 C +ATOM 936 C6 U A 29 -14.034 -7.024 -2.498 1.00 1.00 C +ATOM 937 H5' U A 29 -13.834 -8.633 1.669 1.00 1.00 H +ATOM 938 H5'' U A 29 -13.798 -10.295 1.046 1.00 1.00 H +ATOM 939 H4' U A 29 -16.043 -9.235 0.875 1.00 1.00 H +ATOM 940 H3' U A 29 -14.613 -10.046 -1.664 1.00 1.00 H +ATOM 941 H2' U A 29 -16.368 -9.218 -2.944 1.00 1.00 H +ATOM 942 HO2' U A 29 -18.454 -9.006 -2.197 1.00 1.00 H +ATOM 943 H1' U A 29 -17.113 -7.087 -1.302 1.00 1.00 H +ATOM 944 H3 U A 29 -15.746 -4.972 -5.082 1.00 1.00 H +ATOM 945 H5 U A 29 -12.191 -6.465 -3.377 1.00 1.00 H +ATOM 946 H6 U A 29 -13.545 -7.630 -1.734 1.00 1.00 H +ATOM 947 P U A 30 -15.843 -12.488 -1.566 1.00 1.00 P +ATOM 948 OP1 U A 30 -16.434 -13.634 -0.842 1.00 1.00 O +ATOM 949 OP2 U A 30 -14.411 -12.515 -1.942 1.00 1.00 O +ATOM 950 O5' U A 30 -16.708 -12.237 -2.902 1.00 1.00 O +ATOM 951 C5' U A 30 -18.117 -12.500 -2.925 1.00 1.00 C +ATOM 952 C4' U A 30 -18.726 -12.170 -4.285 1.00 1.00 C +ATOM 953 O4' U A 30 -18.558 -10.784 -4.565 1.00 1.00 O +ATOM 954 C3' U A 30 -18.099 -12.919 -5.452 1.00 1.00 C +ATOM 955 O3' U A 30 -18.773 -14.164 -5.666 1.00 1.00 O +ATOM 956 C2' U A 30 -18.344 -11.982 -6.621 1.00 1.00 C +ATOM 957 O2' U A 30 -19.604 -12.234 -7.250 1.00 1.00 O +ATOM 958 C1' U A 30 -18.305 -10.604 -5.966 1.00 1.00 C +ATOM 959 N1 U A 30 -16.997 -9.938 -6.087 1.00 1.00 N +ATOM 960 C2 U A 30 -16.827 -9.019 -7.105 1.00 1.00 C +ATOM 961 O2 U A 30 -17.722 -8.756 -7.905 1.00 1.00 O +ATOM 962 N3 U A 30 -15.587 -8.408 -7.171 1.00 1.00 N +ATOM 963 C4 U A 30 -14.518 -8.635 -6.321 1.00 1.00 C +ATOM 964 O4 U A 30 -13.458 -8.033 -6.474 1.00 1.00 O +ATOM 965 C5 U A 30 -14.785 -9.610 -5.287 1.00 1.00 C +ATOM 966 C6 U A 30 -15.993 -10.221 -5.202 1.00 1.00 C +ATOM 967 H5' U A 30 -18.605 -11.894 -2.161 1.00 1.00 H +ATOM 968 H5'' U A 30 -18.287 -13.554 -2.707 1.00 1.00 H +ATOM 969 H4' U A 30 -19.791 -12.384 -4.255 1.00 1.00 H +ATOM 970 H3' U A 30 -17.029 -13.064 -5.289 1.00 1.00 H +ATOM 971 H2' U A 30 -17.533 -12.070 -7.337 1.00 1.00 H +ATOM 972 HO2' U A 30 -19.496 -12.046 -8.186 1.00 1.00 H +ATOM 973 H1' U A 30 -19.078 -9.967 -6.393 1.00 1.00 H +ATOM 974 H3 U A 30 -15.449 -7.735 -7.911 1.00 1.00 H +ATOM 975 H5 U A 30 -14.006 -9.858 -4.568 1.00 1.00 H +ATOM 976 H6 U A 30 -16.167 -10.951 -4.411 1.00 1.00 H +ATOM 977 P C A 31 -17.983 -15.425 -6.290 1.00 1.00 P +ATOM 978 OP1 C A 31 -18.935 -16.551 -6.411 1.00 1.00 O +ATOM 979 OP2 C A 31 -16.724 -15.605 -5.530 1.00 1.00 O +ATOM 980 O5' C A 31 -17.609 -14.924 -7.775 1.00 1.00 O +ATOM 981 C5' C A 31 -18.579 -14.959 -8.827 1.00 1.00 C +ATOM 982 C4' C A 31 -18.167 -14.081 -10.003 1.00 1.00 C +ATOM 983 O4' C A 31 -17.819 -12.787 -9.540 1.00 1.00 O +ATOM 984 C3' C A 31 -16.958 -14.577 -10.771 1.00 1.00 C +ATOM 985 O3' C A 31 -17.369 -15.520 -11.765 1.00 1.00 O +ATOM 986 C2' C A 31 -16.441 -13.305 -11.427 1.00 1.00 C +ATOM 987 O2' C A 31 -17.029 -13.094 -12.716 1.00 1.00 O +ATOM 988 C1' C A 31 -16.857 -12.216 -10.436 1.00 1.00 C +ATOM 989 N1 C A 31 -15.741 -11.711 -9.621 1.00 1.00 N +ATOM 990 C2 C A 31 -15.133 -10.534 -10.027 1.00 1.00 C +ATOM 991 O2 C A 31 -15.528 -9.955 -11.038 1.00 1.00 O +ATOM 992 N3 C A 31 -14.100 -10.050 -9.284 1.00 1.00 N +ATOM 993 C4 C A 31 -13.682 -10.693 -8.187 1.00 1.00 C +ATOM 994 N4 C A 31 -12.668 -10.190 -7.482 1.00 1.00 N +ATOM 995 C5 C A 31 -14.307 -11.908 -7.761 1.00 1.00 C +ATOM 996 C6 C A 31 -15.329 -12.379 -8.504 1.00 1.00 C +ATOM 997 H5' C A 31 -19.538 -14.611 -8.442 1.00 1.00 H +ATOM 998 H5'' C A 31 -18.687 -15.986 -9.176 1.00 1.00 H +ATOM 999 H4' C A 31 -19.009 -13.984 -10.684 1.00 1.00 H +ATOM 1000 H3' C A 31 -16.210 -15.002 -10.095 1.00 1.00 H +ATOM 1001 H2' C A 31 -15.355 -13.340 -11.500 1.00 1.00 H +ATOM 1002 HO2' C A 31 -17.864 -13.567 -12.730 1.00 1.00 H +ATOM 1003 H1' C A 31 -17.319 -11.387 -10.973 1.00 1.00 H +ATOM 1004 H41 C A 31 -12.226 -9.332 -7.783 1.00 1.00 H +ATOM 1005 H42 C A 31 -12.342 -10.667 -6.653 1.00 1.00 H +ATOM 1006 H5 C A 31 -13.969 -12.434 -6.868 1.00 1.00 H +ATOM 1007 H6 C A 31 -15.830 -13.301 -8.210 1.00 1.00 H +ATOM 1008 P U A 32 -16.614 -16.936 -11.905 1.00 1.00 P +ATOM 1009 OP1 U A 32 -17.497 -17.857 -12.657 1.00 1.00 O +ATOM 1010 OP2 U A 32 -16.111 -17.325 -10.569 1.00 1.00 O +ATOM 1011 O5' U A 32 -15.349 -16.572 -12.829 1.00 1.00 O +ATOM 1012 C5' U A 32 -15.504 -15.719 -13.965 1.00 1.00 C +ATOM 1013 C4' U A 32 -14.333 -14.746 -14.106 1.00 1.00 C +ATOM 1014 O4' U A 32 -14.280 -13.851 -12.997 1.00 1.00 O +ATOM 1015 C3' U A 32 -12.967 -15.406 -14.163 1.00 1.00 C +ATOM 1016 O3' U A 32 -12.646 -15.729 -15.520 1.00 1.00 O +ATOM 1017 C2' U A 32 -12.026 -14.320 -13.668 1.00 1.00 C +ATOM 1018 O2' U A 32 -11.394 -13.638 -14.753 1.00 1.00 O +ATOM 1019 C1' U A 32 -12.928 -13.382 -12.868 1.00 1.00 C +ATOM 1020 N1 U A 32 -12.570 -13.283 -11.434 1.00 1.00 N +ATOM 1021 C2 U A 32 -11.655 -12.308 -11.083 1.00 1.00 C +ATOM 1022 O2 U A 32 -11.147 -11.559 -11.914 1.00 1.00 O +ATOM 1023 N3 U A 32 -11.343 -12.226 -9.738 1.00 1.00 N +ATOM 1024 C4 U A 32 -11.856 -13.023 -8.730 1.00 1.00 C +ATOM 1025 O4 U A 32 -11.508 -12.860 -7.562 1.00 1.00 O +ATOM 1026 C5 U A 32 -12.804 -14.015 -9.187 1.00 1.00 C +ATOM 1027 C6 U A 32 -13.127 -14.114 -10.500 1.00 1.00 C +ATOM 1028 H5' U A 32 -16.431 -15.153 -13.863 1.00 1.00 H +ATOM 1029 H5'' U A 32 -15.559 -16.334 -14.863 1.00 1.00 H +ATOM 1030 H4' U A 32 -14.478 -14.160 -15.014 1.00 1.00 H +ATOM 1031 H3' U A 32 -12.927 -16.286 -13.518 1.00 1.00 H +ATOM 1032 H2' U A 32 -11.283 -14.760 -13.002 1.00 1.00 H +ATOM 1033 HO2' U A 32 -11.786 -12.763 -14.805 1.00 1.00 H +ATOM 1034 H1' U A 32 -12.869 -12.390 -13.313 1.00 1.00 H +ATOM 1035 H3 U A 32 -10.675 -11.517 -9.466 1.00 1.00 H +ATOM 1036 H5 U A 32 -13.263 -14.692 -8.467 1.00 1.00 H +ATOM 1037 H6 U A 32 -13.844 -14.871 -10.817 1.00 1.00 H +ATOM 1038 P U A 33 -11.370 -16.646 -15.870 1.00 1.00 P +ATOM 1039 OP1 U A 33 -11.415 -16.968 -17.314 1.00 1.00 O +ATOM 1040 OP2 U A 33 -11.298 -17.737 -14.874 1.00 1.00 O +ATOM 1041 O5' U A 33 -10.128 -15.649 -15.618 1.00 1.00 O +ATOM 1042 C5' U A 33 -9.800 -14.634 -16.574 1.00 1.00 C +ATOM 1043 C4' U A 33 -8.534 -13.872 -16.183 1.00 1.00 C +ATOM 1044 O4' U A 33 -8.734 -13.207 -14.942 1.00 1.00 O +ATOM 1045 C3' U A 33 -7.306 -14.746 -16.006 1.00 1.00 C +ATOM 1046 O3' U A 33 -6.593 -14.826 -17.242 1.00 1.00 O +ATOM 1047 C2' U A 33 -6.468 -13.994 -14.980 1.00 1.00 C +ATOM 1048 O2' U A 33 -5.458 -13.201 -15.611 1.00 1.00 O +ATOM 1049 C1' U A 33 -7.483 -13.118 -14.245 1.00 1.00 C +ATOM 1050 N1 U A 33 -7.720 -13.534 -12.851 1.00 1.00 N +ATOM 1051 C2 U A 33 -7.017 -12.881 -11.855 1.00 1.00 C +ATOM 1052 O2 U A 33 -6.218 -11.981 -12.101 1.00 1.00 O +ATOM 1053 N3 U A 33 -7.268 -13.301 -10.560 1.00 1.00 N +ATOM 1054 C4 U A 33 -8.146 -14.302 -10.181 1.00 1.00 C +ATOM 1055 O4 U A 33 -8.290 -14.595 -8.996 1.00 1.00 O +ATOM 1056 C5 U A 33 -8.836 -14.928 -11.287 1.00 1.00 C +ATOM 1057 C6 U A 33 -8.608 -14.534 -12.563 1.00 1.00 C +ATOM 1058 H5' U A 33 -10.630 -13.929 -16.645 1.00 1.00 H +ATOM 1059 H5'' U A 33 -9.646 -15.098 -17.547 1.00 1.00 H +ATOM 1060 H4' U A 33 -8.327 -13.122 -16.943 1.00 1.00 H +ATOM 1061 H3' U A 33 -7.579 -15.737 -15.636 1.00 1.00 H +ATOM 1062 H2' U A 33 -6.019 -14.704 -14.281 1.00 1.00 H +ATOM 1063 HO2' U A 33 -5.114 -12.599 -14.946 1.00 1.00 H +ATOM 1064 H1' U A 33 -7.141 -12.084 -14.263 1.00 1.00 H +ATOM 1065 H3 U A 33 -6.761 -12.833 -9.821 1.00 1.00 H +ATOM 1066 H5 U A 33 -9.549 -15.729 -11.091 1.00 1.00 H +ATOM 1067 H6 U A 33 -9.143 -15.023 -13.378 1.00 1.00 H +ATOM 1068 P C A 34 -5.428 -15.918 -17.440 1.00 1.00 P +ATOM 1069 OP1 C A 34 -4.947 -15.833 -18.838 1.00 1.00 O +ATOM 1070 OP2 C A 34 -5.907 -17.211 -16.901 1.00 1.00 O +ATOM 1071 O5' C A 34 -4.264 -15.366 -16.473 1.00 1.00 O +ATOM 1072 C5' C A 34 -3.535 -16.261 -15.628 1.00 1.00 C +ATOM 1073 C4' C A 34 -2.501 -15.519 -14.782 1.00 1.00 C +ATOM 1074 O4' C A 34 -3.162 -14.702 -13.819 1.00 1.00 O +ATOM 1075 C3' C A 34 -1.561 -16.435 -14.014 1.00 1.00 C +ATOM 1076 O3' C A 34 -0.369 -16.650 -14.775 1.00 1.00 O +ATOM 1077 C2' C A 34 -1.231 -15.652 -12.753 1.00 1.00 C +ATOM 1078 O2' C A 34 0.006 -14.946 -12.892 1.00 1.00 O +ATOM 1079 C1' C A 34 -2.409 -14.689 -12.599 1.00 1.00 C +ATOM 1080 N1 C A 34 -3.332 -15.045 -11.508 1.00 1.00 N +ATOM 1081 C2 C A 34 -2.956 -14.704 -10.220 1.00 1.00 C +ATOM 1082 O2 C A 34 -1.887 -14.129 -10.022 1.00 1.00 O +ATOM 1083 N3 C A 34 -3.796 -15.020 -9.196 1.00 1.00 N +ATOM 1084 C4 C A 34 -4.959 -15.646 -9.429 1.00 1.00 C +ATOM 1085 N4 C A 34 -5.758 -15.942 -8.406 1.00 1.00 N +ATOM 1086 C5 C A 34 -5.350 -15.999 -10.759 1.00 1.00 C +ATOM 1087 C6 C A 34 -4.511 -15.681 -11.764 1.00 1.00 C +ATOM 1088 H5' C A 34 -3.025 -16.998 -16.247 1.00 1.00 H +ATOM 1089 H5'' C A 34 -4.234 -16.772 -14.967 1.00 1.00 H +ATOM 1090 H4' C A 34 -1.913 -14.876 -15.433 1.00 1.00 H +ATOM 1091 H3' C A 34 -2.052 -17.379 -13.769 1.00 1.00 H +ATOM 1092 H2' C A 34 -1.192 -16.332 -11.896 1.00 1.00 H +ATOM 1093 HO2' C A 34 0.494 -15.360 -13.608 1.00 1.00 H +ATOM 1094 H1' C A 34 -2.025 -13.685 -12.426 1.00 1.00 H +ATOM 1095 H41 C A 34 -5.487 -15.694 -7.467 1.00 1.00 H +ATOM 1096 H42 C A 34 -6.636 -16.413 -8.572 1.00 1.00 H +ATOM 1097 H5 C A 34 -6.295 -16.508 -10.953 1.00 1.00 H +ATOM 1098 H6 C A 34 -4.778 -15.934 -12.791 1.00 1.00 H +ATOM 1099 P C A 35 0.560 -17.934 -14.492 1.00 1.00 P +ATOM 1100 OP1 C A 35 1.814 -17.777 -15.263 1.00 1.00 O +ATOM 1101 OP2 C A 35 -0.264 -19.151 -14.661 1.00 1.00 O +ATOM 1102 O5' C A 35 0.909 -17.772 -12.928 1.00 1.00 O +ATOM 1103 C5' C A 35 1.009 -18.922 -12.083 1.00 1.00 C +ATOM 1104 C4' C A 35 1.859 -18.639 -10.847 1.00 1.00 C +ATOM 1105 O4' C A 35 1.226 -17.643 -10.042 1.00 1.00 O +ATOM 1106 C3' C A 35 2.085 -19.855 -9.962 1.00 1.00 C +ATOM 1107 O3' C A 35 3.338 -20.461 -10.291 1.00 1.00 O +ATOM 1108 C2' C A 35 2.144 -19.285 -8.555 1.00 1.00 C +ATOM 1109 O2' C A 35 3.497 -19.040 -8.151 1.00 1.00 O +ATOM 1110 C1' C A 35 1.351 -17.984 -8.655 1.00 1.00 C +ATOM 1111 N1 C A 35 -0.011 -18.070 -8.094 1.00 1.00 N +ATOM 1112 C2 C A 35 -0.130 -18.193 -6.719 1.00 1.00 C +ATOM 1113 O2 C A 35 0.878 -18.229 -6.016 1.00 1.00 O +ATOM 1114 N3 C A 35 -1.378 -18.273 -6.184 1.00 1.00 N +ATOM 1115 C4 C A 35 -2.466 -18.234 -6.964 1.00 1.00 C +ATOM 1116 N4 C A 35 -3.674 -18.315 -6.408 1.00 1.00 N +ATOM 1117 C5 C A 35 -2.348 -18.108 -8.385 1.00 1.00 C +ATOM 1118 C6 C A 35 -1.108 -18.029 -8.905 1.00 1.00 C +ATOM 1119 H5' C A 35 1.460 -19.739 -12.645 1.00 1.00 H +ATOM 1120 H5'' C A 35 0.008 -19.218 -11.766 1.00 1.00 H +ATOM 1121 H4' C A 35 2.826 -18.255 -11.169 1.00 1.00 H +ATOM 1122 H3' C A 35 1.262 -20.565 -10.060 1.00 1.00 H +ATOM 1123 H2' C A 35 1.653 -19.968 -7.856 1.00 1.00 H +ATOM 1124 HO2' C A 35 3.538 -18.140 -7.820 1.00 1.00 H +ATOM 1125 H1' C A 35 1.896 -17.194 -8.141 1.00 1.00 H +ATOM 1126 H41 C A 35 -3.764 -18.404 -5.403 1.00 1.00 H +ATOM 1127 H42 C A 35 -4.500 -18.287 -6.988 1.00 1.00 H +ATOM 1128 H5 C A 35 -3.231 -18.077 -9.024 1.00 1.00 H +ATOM 1129 H6 C A 35 -0.979 -17.933 -9.983 1.00 1.00 H +ATOM 1130 P U A 36 3.697 -21.938 -9.758 1.00 1.00 P +ATOM 1131 OP1 U A 36 4.944 -22.382 -10.421 1.00 1.00 O +ATOM 1132 OP2 U A 36 2.476 -22.771 -9.848 1.00 1.00 O +ATOM 1133 O5' U A 36 4.017 -21.680 -8.202 1.00 1.00 O +ATOM 1134 C5' U A 36 3.831 -22.720 -7.241 1.00 1.00 C +ATOM 1135 C4' U A 36 4.009 -22.207 -5.815 1.00 1.00 C +ATOM 1136 O4' U A 36 2.986 -21.260 -5.513 1.00 1.00 O +ATOM 1137 C3' U A 36 3.939 -23.297 -4.758 1.00 1.00 C +ATOM 1138 O3' U A 36 5.268 -23.734 -4.444 1.00 1.00 O +ATOM 1139 C2' U A 36 3.314 -22.607 -3.553 1.00 1.00 C +ATOM 1140 O2' U A 36 4.311 -22.157 -2.630 1.00 1.00 O +ATOM 1141 C1' U A 36 2.548 -21.431 -4.158 1.00 1.00 C +ATOM 1142 N1 U A 36 1.086 -21.623 -4.184 1.00 1.00 N +ATOM 1143 C2 U A 36 0.436 -21.705 -2.968 1.00 1.00 C +ATOM 1144 O2 U A 36 1.036 -21.632 -1.898 1.00 1.00 O +ATOM 1145 N3 U A 36 -0.936 -21.875 -3.024 1.00 1.00 N +ATOM 1146 C4 U A 36 -1.701 -21.969 -4.175 1.00 1.00 C +ATOM 1147 O4 U A 36 -2.919 -22.120 -4.107 1.00 1.00 O +ATOM 1148 C5 U A 36 -0.938 -21.874 -5.399 1.00 1.00 C +ATOM 1149 C6 U A 36 0.406 -21.706 -5.369 1.00 1.00 C +ATOM 1150 H5' U A 36 4.557 -23.511 -7.426 1.00 1.00 H +ATOM 1151 H5'' U A 36 2.826 -23.129 -7.348 1.00 1.00 H +ATOM 1152 H4' U A 36 4.973 -21.707 -5.741 1.00 1.00 H +ATOM 1153 H3' U A 36 3.318 -24.128 -5.098 1.00 1.00 H +ATOM 1154 H2' U A 36 2.615 -23.288 -3.061 1.00 1.00 H +ATOM 1155 HO2' U A 36 3.861 -21.927 -1.813 1.00 1.00 H +ATOM 1156 H1' U A 36 2.777 -20.528 -3.593 1.00 1.00 H +ATOM 1157 H3 U A 36 -1.426 -21.936 -2.144 1.00 1.00 H +ATOM 1158 H5 U A 36 -1.451 -21.936 -6.359 1.00 1.00 H +ATOM 1159 H6 U A 36 0.958 -21.639 -6.307 1.00 1.00 H +ATOM 1160 P A A 37 5.559 -25.270 -4.052 1.00 1.00 P +ATOM 1161 OP1 A A 37 7.025 -25.464 -3.997 1.00 1.00 O +ATOM 1162 OP2 A A 37 4.733 -26.135 -4.926 1.00 1.00 O +ATOM 1163 O5' A A 37 4.978 -25.367 -2.555 1.00 1.00 O +ATOM 1164 C5' A A 37 5.547 -24.581 -1.504 1.00 1.00 C +ATOM 1165 C4' A A 37 4.681 -24.615 -0.249 1.00 1.00 C +ATOM 1166 O4' A A 37 3.348 -24.222 -0.584 1.00 1.00 O +ATOM 1167 C3' A A 37 4.603 -25.988 0.408 1.00 1.00 C +ATOM 1168 O3' A A 37 4.585 -25.830 1.831 1.00 1.00 O +ATOM 1169 C2' A A 37 3.273 -26.555 -0.060 1.00 1.00 C +ATOM 1170 O2' A A 37 2.654 -27.346 0.962 1.00 1.00 O +ATOM 1171 C1' A A 37 2.446 -25.316 -0.379 1.00 1.00 C +ATOM 1172 N9 A A 37 1.621 -25.445 -1.592 1.00 1.00 N +ATOM 1173 C8 A A 37 1.990 -25.880 -2.840 1.00 1.00 C +ATOM 1174 N7 A A 37 1.018 -25.875 -3.709 1.00 1.00 N +ATOM 1175 C5 A A 37 -0.074 -25.405 -2.985 1.00 1.00 C +ATOM 1176 C6 A A 37 -1.413 -25.166 -3.336 1.00 1.00 C +ATOM 1177 N6 A A 37 -1.897 -25.381 -4.560 1.00 1.00 N +ATOM 1178 N1 A A 37 -2.228 -24.699 -2.375 1.00 1.00 N +ATOM 1179 C2 A A 37 -1.739 -24.488 -1.158 1.00 1.00 C +ATOM 1180 N3 A A 37 -0.508 -24.672 -0.708 1.00 1.00 N +ATOM 1181 C4 A A 37 0.285 -25.141 -1.695 1.00 1.00 C +ATOM 1182 H5' A A 37 5.644 -23.549 -1.842 1.00 1.00 H +ATOM 1183 H5'' A A 37 6.537 -24.972 -1.265 1.00 1.00 H +ATOM 1184 H4' A A 37 5.077 -23.903 0.471 1.00 1.00 H +ATOM 1185 H3' A A 37 5.432 -26.623 0.089 1.00 1.00 H +ATOM 1186 H2' A A 37 3.420 -27.146 -0.968 1.00 1.00 H +ATOM 1187 HO2' A A 37 1.709 -27.175 0.921 1.00 1.00 H +ATOM 1188 H1' A A 37 1.797 -25.092 0.468 1.00 1.00 H +ATOM 1189 H8 A A 37 3.003 -26.199 -3.083 1.00 1.00 H +ATOM 1190 H61 A A 37 -2.870 -25.194 -4.758 1.00 1.00 H +ATOM 1191 H62 A A 37 -1.292 -25.733 -5.288 1.00 1.00 H +ATOM 1192 H2 A A 37 -2.454 -24.110 -0.427 1.00 1.00 H +ATOM 1193 P A A 38 5.097 -27.014 2.793 1.00 1.00 P +ATOM 1194 OP1 A A 38 6.573 -27.081 2.698 1.00 1.00 O +ATOM 1195 OP2 A A 38 4.283 -28.219 2.518 1.00 1.00 O +ATOM 1196 O5' A A 38 4.710 -26.467 4.257 1.00 1.00 O +ATOM 1197 C5' A A 38 5.605 -25.613 4.976 1.00 1.00 C +ATOM 1198 C4' A A 38 4.875 -24.813 6.051 1.00 1.00 C +ATOM 1199 O4' A A 38 4.324 -23.628 5.469 1.00 1.00 O +ATOM 1200 C3' A A 38 3.734 -25.577 6.713 1.00 1.00 C +ATOM 1201 O3' A A 38 4.167 -26.092 7.976 1.00 1.00 O +ATOM 1202 C2' A A 38 2.661 -24.524 6.935 1.00 1.00 C +ATOM 1203 O2' A A 38 2.746 -23.963 8.250 1.00 1.00 O +ATOM 1204 C1' A A 38 2.957 -23.478 5.867 1.00 1.00 C +ATOM 1205 N9 A A 38 2.125 -23.611 4.657 1.00 1.00 N +ATOM 1206 C8 A A 38 2.453 -24.158 3.443 1.00 1.00 C +ATOM 1207 N7 A A 38 1.484 -24.126 2.571 1.00 1.00 N +ATOM 1208 C5 A A 38 0.439 -23.514 3.256 1.00 1.00 C +ATOM 1209 C6 A A 38 -0.874 -23.183 2.885 1.00 1.00 C +ATOM 1210 N6 A A 38 -1.379 -23.436 1.676 1.00 1.00 N +ATOM 1211 N1 A A 38 -1.643 -22.583 3.810 1.00 1.00 N +ATOM 1212 C2 A A 38 -1.136 -22.334 5.010 1.00 1.00 C +ATOM 1213 N3 A A 38 0.075 -22.596 5.478 1.00 1.00 N +ATOM 1214 C4 A A 38 0.821 -23.197 4.528 1.00 1.00 C +ATOM 1215 H5' A A 38 6.075 -24.921 4.276 1.00 1.00 H +ATOM 1216 H5'' A A 38 6.377 -26.220 5.447 1.00 1.00 H +ATOM 1217 H4' A A 38 5.590 -24.519 6.816 1.00 1.00 H +ATOM 1218 H3' A A 38 3.369 -26.373 6.062 1.00 1.00 H +ATOM 1219 H2' A A 38 1.673 -24.957 6.764 1.00 1.00 H +ATOM 1220 HO2' A A 38 3.671 -23.969 8.504 1.00 1.00 H +ATOM 1221 H1' A A 38 2.813 -22.484 6.289 1.00 1.00 H +ATOM 1222 H8 A A 38 3.435 -24.580 3.228 1.00 1.00 H +ATOM 1223 H61 A A 38 -2.331 -23.177 1.461 1.00 1.00 H +ATOM 1224 H62 A A 38 -0.807 -23.887 0.976 1.00 1.00 H +ATOM 1225 H2 A A 38 -1.814 -21.846 5.711 1.00 1.00 H +ATOM 1226 P G A 39 3.216 -27.077 8.827 1.00 1.00 P +ATOM 1227 OP1 G A 39 4.079 -27.983 9.618 1.00 1.00 O +ATOM 1228 OP2 G A 39 2.196 -27.639 7.914 1.00 1.00 O +ATOM 1229 O5' G A 39 2.481 -26.067 9.843 1.00 1.00 O +ATOM 1230 C5' G A 39 1.206 -26.394 10.405 1.00 1.00 C +ATOM 1231 C4' G A 39 0.246 -25.210 10.333 1.00 1.00 C +ATOM 1232 O4' G A 39 0.315 -24.617 9.035 1.00 1.00 O +ATOM 1233 C3' G A 39 -1.210 -25.581 10.594 1.00 1.00 C +ATOM 1234 O3' G A 39 -1.553 -25.250 11.944 1.00 1.00 O +ATOM 1235 C2' G A 39 -1.994 -24.702 9.634 1.00 1.00 C +ATOM 1236 O2' G A 39 -2.409 -23.482 10.258 1.00 1.00 O +ATOM 1237 C1' G A 39 -1.004 -24.442 8.508 1.00 1.00 C +ATOM 1238 N9 G A 39 -1.149 -25.361 7.367 1.00 1.00 N +ATOM 1239 C8 G A 39 -0.397 -26.464 7.055 1.00 1.00 C +ATOM 1240 N7 G A 39 -0.780 -27.075 5.970 1.00 1.00 N +ATOM 1241 C5 G A 39 -1.866 -26.324 5.527 1.00 1.00 C +ATOM 1242 C6 G A 39 -2.696 -26.507 4.388 1.00 1.00 C +ATOM 1243 O6 G A 39 -2.633 -27.384 3.530 1.00 1.00 O +ATOM 1244 N1 G A 39 -3.675 -25.526 4.308 1.00 1.00 N +ATOM 1245 C2 G A 39 -3.840 -24.498 5.212 1.00 1.00 C +ATOM 1246 N2 G A 39 -4.838 -23.651 4.967 1.00 1.00 N +ATOM 1247 N3 G A 39 -3.061 -24.324 6.285 1.00 1.00 N +ATOM 1248 C4 G A 39 -2.098 -25.272 6.378 1.00 1.00 C +ATOM 1249 H5' G A 39 1.340 -26.680 11.447 1.00 1.00 H +ATOM 1250 H5'' G A 39 0.779 -27.234 9.858 1.00 1.00 H +ATOM 1251 H4' G A 39 0.554 -24.467 11.066 1.00 1.00 H +ATOM 1252 H3' G A 39 -1.386 -26.638 10.388 1.00 1.00 H +ATOM 1253 H2' G A 39 -2.856 -25.249 9.248 1.00 1.00 H +ATOM 1254 HO2' G A 39 -3.367 -23.444 10.200 1.00 1.00 H +ATOM 1255 H1' G A 39 -1.119 -23.417 8.155 1.00 1.00 H +ATOM 1256 H8 G A 39 0.447 -26.799 7.658 1.00 1.00 H +ATOM 1257 H1 G A 39 -4.306 -25.589 3.522 1.00 1.00 H +ATOM 1258 H21 G A 39 -5.426 -23.783 4.156 1.00 1.00 H +ATOM 1259 H22 G A 39 -5.009 -22.877 5.593 1.00 1.00 H +ATOM 1260 P U A 40 -2.362 -26.294 12.865 1.00 1.00 P +ATOM 1261 OP1 U A 40 -2.505 -25.705 14.215 1.00 1.00 O +ATOM 1262 OP2 U A 40 -1.742 -27.628 12.705 1.00 1.00 O +ATOM 1263 O5' U A 40 -3.816 -26.329 12.174 1.00 1.00 O +ATOM 1264 C5' U A 40 -4.774 -25.299 12.437 1.00 1.00 C +ATOM 1265 C4' U A 40 -6.066 -25.524 11.655 1.00 1.00 C +ATOM 1266 O4' U A 40 -5.815 -25.365 10.259 1.00 1.00 O +ATOM 1267 C3' U A 40 -6.670 -26.909 11.845 1.00 1.00 C +ATOM 1268 O3' U A 40 -7.657 -26.867 12.882 1.00 1.00 O +ATOM 1269 C2' U A 40 -7.339 -27.194 10.510 1.00 1.00 C +ATOM 1270 O2' U A 40 -8.711 -26.785 10.516 1.00 1.00 O +ATOM 1271 C1' U A 40 -6.519 -26.371 9.520 1.00 1.00 C +ATOM 1272 N1 U A 40 -5.510 -27.159 8.783 1.00 1.00 N +ATOM 1273 C2 U A 40 -5.856 -27.646 7.537 1.00 1.00 C +ATOM 1274 O2 U A 40 -6.964 -27.448 7.042 1.00 1.00 O +ATOM 1275 N3 U A 40 -4.882 -28.373 6.877 1.00 1.00 N +ATOM 1276 C4 U A 40 -3.610 -28.650 7.347 1.00 1.00 C +ATOM 1277 O4 U A 40 -2.821 -29.307 6.672 1.00 1.00 O +ATOM 1278 C5 U A 40 -3.335 -28.102 8.658 1.00 1.00 C +ATOM 1279 C6 U A 40 -4.273 -27.386 9.323 1.00 1.00 C +ATOM 1280 H5' U A 40 -4.349 -24.335 12.151 1.00 1.00 H +ATOM 1281 H5'' U A 40 -5.001 -25.286 13.502 1.00 1.00 H +ATOM 1282 H4' U A 40 -6.795 -24.776 11.960 1.00 1.00 H +ATOM 1283 H3' U A 40 -5.896 -27.647 12.060 1.00 1.00 H +ATOM 1284 H2' U A 40 -7.254 -28.256 10.270 1.00 1.00 H +ATOM 1285 HO2' U A 40 -8.905 -26.424 9.649 1.00 1.00 H +ATOM 1286 H1' U A 40 -7.191 -25.890 8.809 1.00 1.00 H +ATOM 1287 H3 U A 40 -5.121 -28.735 5.965 1.00 1.00 H +ATOM 1288 H5 U A 40 -2.359 -28.265 9.115 1.00 1.00 H +ATOM 1289 H6 U A 40 -4.040 -26.983 10.308 1.00 1.00 H +ATOM 1290 P C A 41 -7.737 -28.039 13.984 1.00 1.00 P +ATOM 1291 OP1 C A 41 -8.845 -27.725 14.914 1.00 1.00 O +ATOM 1292 OP2 C A 41 -6.375 -28.271 14.513 1.00 1.00 O +ATOM 1293 O5' C A 41 -8.162 -29.322 13.109 1.00 1.00 O +ATOM 1294 C5' C A 41 -9.514 -29.491 12.681 1.00 1.00 C +ATOM 1295 C4' C A 41 -9.614 -30.454 11.499 1.00 1.00 C +ATOM 1296 O4' C A 41 -8.730 -30.048 10.457 1.00 1.00 O +ATOM 1297 C3' C A 41 -9.243 -31.889 11.832 1.00 1.00 C +ATOM 1298 O3' C A 41 -10.413 -32.607 12.240 1.00 1.00 O +ATOM 1299 C2' C A 41 -8.739 -32.449 10.512 1.00 1.00 C +ATOM 1300 O2' C A 41 -9.761 -33.191 9.835 1.00 1.00 O +ATOM 1301 C1' C A 41 -8.326 -31.209 9.716 1.00 1.00 C +ATOM 1302 N1 C A 41 -6.870 -31.124 9.453 1.00 1.00 N +ATOM 1303 C2 C A 41 -6.419 -31.679 8.266 1.00 1.00 C +ATOM 1304 O2 C A 41 -7.214 -32.205 7.490 1.00 1.00 O +ATOM 1305 N3 C A 41 -5.085 -31.621 7.993 1.00 1.00 N +ATOM 1306 C4 C A 41 -4.232 -31.045 8.850 1.00 1.00 C +ATOM 1307 N4 C A 41 -2.933 -31.006 8.553 1.00 1.00 N +ATOM 1308 C5 C A 41 -4.695 -30.472 10.076 1.00 1.00 C +ATOM 1309 C6 C A 41 -6.015 -30.533 10.337 1.00 1.00 C +ATOM 1310 H5' C A 41 -9.921 -28.522 12.389 1.00 1.00 H +ATOM 1311 H5'' C A 41 -10.100 -29.888 13.509 1.00 1.00 H +ATOM 1312 H4' C A 41 -10.635 -30.433 11.116 1.00 1.00 H +ATOM 1313 H3' C A 41 -8.465 -31.924 12.595 1.00 1.00 H +ATOM 1314 H2' C A 41 -7.861 -33.075 10.693 1.00 1.00 H +ATOM 1315 HO2' C A 41 -10.197 -32.587 9.228 1.00 1.00 H +ATOM 1316 H1' C A 41 -8.857 -31.214 8.762 1.00 1.00 H +ATOM 1317 H41 C A 41 -2.600 -31.411 7.688 1.00 1.00 H +ATOM 1318 H42 C A 41 -2.282 -30.575 9.192 1.00 1.00 H +ATOM 1319 H5 C A 41 -4.002 -30.002 10.776 1.00 1.00 H +ATOM 1320 H6 C A 41 -6.403 -30.107 11.261 1.00 1.00 H +ATOM 1321 P C A 42 -10.288 -34.074 12.891 1.00 1.00 P +ATOM 1322 OP1 C A 42 -11.518 -34.344 13.668 1.00 1.00 O +ATOM 1323 OP2 C A 42 -8.965 -34.177 13.546 1.00 1.00 O +ATOM 1324 O5' C A 42 -10.288 -35.039 11.601 1.00 1.00 O +ATOM 1325 C5' C A 42 -11.471 -35.211 10.813 1.00 1.00 C +ATOM 1326 C4' C A 42 -11.271 -36.266 9.727 1.00 1.00 C +ATOM 1327 O4' C A 42 -10.363 -35.792 8.736 1.00 1.00 O +ATOM 1328 C3' C A 42 -10.703 -37.579 10.238 1.00 1.00 C +ATOM 1329 O3' C A 42 -11.764 -38.457 10.625 1.00 1.00 O +ATOM 1330 C2' C A 42 -9.973 -38.141 9.031 1.00 1.00 C +ATOM 1331 O2' C A 42 -10.812 -39.020 8.275 1.00 1.00 O +ATOM 1332 C1' C A 42 -9.599 -36.896 8.229 1.00 1.00 C +ATOM 1333 N1 C A 42 -8.178 -36.530 8.334 1.00 1.00 N +ATOM 1334 C2 C A 42 -7.270 -37.240 7.564 1.00 1.00 C +ATOM 1335 O2 C A 42 -7.661 -38.148 6.834 1.00 1.00 O +ATOM 1336 N3 C A 42 -5.953 -36.904 7.645 1.00 1.00 N +ATOM 1337 C4 C A 42 -5.544 -35.913 8.449 1.00 1.00 C +ATOM 1338 N4 C A 42 -4.247 -35.611 8.503 1.00 1.00 N +ATOM 1339 C5 C A 42 -6.478 -35.179 9.247 1.00 1.00 C +ATOM 1340 C6 C A 42 -7.779 -35.518 9.159 1.00 1.00 C +ATOM 1341 H5' C A 42 -11.728 -34.262 10.343 1.00 1.00 H +ATOM 1342 H5'' C A 42 -12.290 -35.521 11.463 1.00 1.00 H +ATOM 1343 H4' C A 42 -12.228 -36.460 9.248 1.00 1.00 H +ATOM 1344 H3' C A 42 -10.009 -37.404 11.065 1.00 1.00 H +ATOM 1345 H2' C A 42 -9.069 -38.656 9.354 1.00 1.00 H +ATOM 1346 HO2' C A 42 -10.564 -38.927 7.354 1.00 1.00 H +ATOM 1347 H1' C A 42 -9.849 -37.054 7.182 1.00 1.00 H +ATOM 1348 H41 C A 42 -3.583 -36.126 7.942 1.00 1.00 H +ATOM 1349 H42 C A 42 -3.927 -34.866 9.105 1.00 1.00 H +ATOM 1350 H5 C A 42 -6.147 -34.373 9.902 1.00 1.00 H +ATOM 1351 H6 C A 42 -8.517 -34.982 9.753 1.00 1.00 H +ATOM 1352 P U A 43 -11.499 -39.631 11.696 1.00 1.00 P +ATOM 1353 OP1 U A 43 -12.729 -40.449 11.802 1.00 1.00 O +ATOM 1354 OP2 U A 43 -10.908 -39.028 12.911 1.00 1.00 O +ATOM 1355 O5' U A 43 -10.366 -40.517 10.971 1.00 1.00 O +ATOM 1356 C5' U A 43 -10.654 -41.222 9.760 1.00 1.00 C +ATOM 1357 C4' U A 43 -9.422 -41.957 9.232 1.00 1.00 C +ATOM 1358 O4' U A 43 -8.434 -41.020 8.830 1.00 1.00 O +ATOM 1359 C3' U A 43 -8.755 -42.872 10.247 1.00 1.00 C +ATOM 1360 O3' U A 43 -9.299 -44.197 10.191 1.00 1.00 O +ATOM 1361 C2' U A 43 -7.281 -42.852 9.840 1.00 1.00 C +ATOM 1362 O2' U A 43 -6.904 -44.071 9.190 1.00 1.00 O +ATOM 1363 C1' U A 43 -7.157 -41.660 8.892 1.00 1.00 C +ATOM 1364 N1 U A 43 -6.172 -40.654 9.339 1.00 1.00 N +ATOM 1365 C2 U A 43 -4.894 -40.727 8.817 1.00 1.00 C +ATOM 1366 O2 U A 43 -4.565 -41.592 8.010 1.00 1.00 O +ATOM 1367 N3 U A 43 -4.003 -39.766 9.259 1.00 1.00 N +ATOM 1368 C4 U A 43 -4.275 -38.753 10.163 1.00 1.00 C +ATOM 1369 O4 U A 43 -3.403 -37.947 10.481 1.00 1.00 O +ATOM 1370 C5 U A 43 -5.634 -38.755 10.657 1.00 1.00 C +ATOM 1371 C6 U A 43 -6.524 -39.686 10.239 1.00 1.00 C +ATOM 1372 H5' U A 43 -10.997 -40.513 9.007 1.00 1.00 H +ATOM 1373 H5'' U A 43 -11.444 -41.949 9.952 1.00 1.00 H +ATOM 1374 H4' U A 43 -9.710 -42.546 8.364 1.00 1.00 H +ATOM 1375 H3' U A 43 -8.866 -42.452 11.251 1.00 1.00 H +ATOM 1376 HO3' U A 43 -10.205 -44.120 9.882 1.00 1.00 H +ATOM 1377 H2' U A 43 -6.656 -42.679 10.719 1.00 1.00 H +ATOM 1378 HO2' U A 43 -5.997 -43.965 8.891 1.00 1.00 H +ATOM 1379 H1' U A 43 -6.888 -42.018 7.897 1.00 1.00 H +ATOM 1380 H3 U A 43 -3.064 -39.805 8.885 1.00 1.00 H +ATOM 1381 H5 U A 43 -5.947 -37.997 11.374 1.00 1.00 H +ATOM 1382 H6 U A 43 -7.542 -39.665 10.627 1.00 1.00 H +TER 1383 U A 43 +ATOM 1384 O5' G B 44 -4.499 37.733 16.122 1.00 1.00 O +ATOM 1385 C5' G B 44 -5.387 38.743 15.640 1.00 1.00 C +ATOM 1386 C4' G B 44 -4.682 39.689 14.670 1.00 1.00 C +ATOM 1387 O4' G B 44 -3.765 40.517 15.388 1.00 1.00 O +ATOM 1388 C3' G B 44 -3.896 38.975 13.574 1.00 1.00 C +ATOM 1389 O3' G B 44 -4.656 38.962 12.362 1.00 1.00 O +ATOM 1390 C2' G B 44 -2.660 39.837 13.389 1.00 1.00 C +ATOM 1391 O2' G B 44 -2.854 40.818 12.366 1.00 1.00 O +ATOM 1392 C1' G B 44 -2.483 40.482 14.753 1.00 1.00 C +ATOM 1393 N9 G B 44 -1.575 39.742 15.638 1.00 1.00 N +ATOM 1394 C8 G B 44 -1.886 38.917 16.687 1.00 1.00 C +ATOM 1395 N7 G B 44 -0.847 38.403 17.282 1.00 1.00 N +ATOM 1396 C5 G B 44 0.234 38.926 16.579 1.00 1.00 C +ATOM 1397 C6 G B 44 1.628 38.721 16.769 1.00 1.00 C +ATOM 1398 O6 G B 44 2.190 38.023 17.611 1.00 1.00 O +ATOM 1399 N1 G B 44 2.380 39.434 15.843 1.00 1.00 N +ATOM 1400 C2 G B 44 1.859 40.242 14.856 1.00 1.00 C +ATOM 1401 N2 G B 44 2.743 40.846 14.062 1.00 1.00 N +ATOM 1402 N3 G B 44 0.548 40.437 14.674 1.00 1.00 N +ATOM 1403 C4 G B 44 -0.201 39.748 15.569 1.00 1.00 C +ATOM 1404 H5' G B 44 -5.772 39.310 16.491 1.00 1.00 H +ATOM 1405 H5'' G B 44 -6.221 38.272 15.126 1.00 1.00 H +ATOM 1406 H4' G B 44 -5.428 40.330 14.204 1.00 1.00 H +ATOM 1407 H3' G B 44 -3.624 37.965 13.886 1.00 1.00 H +ATOM 1408 H2' G B 44 -1.798 39.207 13.163 1.00 1.00 H +ATOM 1409 HO2' G B 44 -3.742 41.165 12.469 1.00 1.00 H +ATOM 1410 H1' G B 44 -2.112 41.498 14.628 1.00 1.00 H +ATOM 1411 H8 G B 44 -2.911 38.709 16.997 1.00 1.00 H +ATOM 1412 H1 G B 44 3.383 39.337 15.917 1.00 1.00 H +ATOM 1413 H21 G B 44 3.732 40.699 14.201 1.00 1.00 H +ATOM 1414 H22 G B 44 2.422 41.452 13.320 1.00 1.00 H +ATOM 1415 HO5' G B 44 -5.030 37.088 16.595 1.00 1.00 H +ATOM 1416 P G B 45 -4.372 37.850 11.233 1.00 1.00 P +ATOM 1417 OP1 G B 45 -5.141 38.217 10.022 1.00 1.00 O +ATOM 1418 OP2 G B 45 -4.551 36.514 11.843 1.00 1.00 O +ATOM 1419 O5' G B 45 -2.805 38.054 10.916 1.00 1.00 O +ATOM 1420 C5' G B 45 -2.339 39.225 10.237 1.00 1.00 C +ATOM 1421 C4' G B 45 -0.828 39.181 10.017 1.00 1.00 C +ATOM 1422 O4' G B 45 -0.145 39.227 11.267 1.00 1.00 O +ATOM 1423 C3' G B 45 -0.344 37.927 9.310 1.00 1.00 C +ATOM 1424 O3' G B 45 -0.351 38.137 7.891 1.00 1.00 O +ATOM 1425 C2' G B 45 1.081 37.756 9.817 1.00 1.00 C +ATOM 1426 O2' G B 45 2.033 38.312 8.902 1.00 1.00 O +ATOM 1427 C1' G B 45 1.087 38.501 11.154 1.00 1.00 C +ATOM 1428 N9 G B 45 1.194 37.613 12.325 1.00 1.00 N +ATOM 1429 C8 G B 45 0.192 37.031 13.059 1.00 1.00 C +ATOM 1430 N7 G B 45 0.621 36.297 14.048 1.00 1.00 N +ATOM 1431 C5 G B 45 2.007 36.397 13.965 1.00 1.00 C +ATOM 1432 C6 G B 45 3.014 35.809 14.780 1.00 1.00 C +ATOM 1433 O6 G B 45 2.875 35.070 15.752 1.00 1.00 O +ATOM 1434 N1 G B 45 4.286 36.167 14.353 1.00 1.00 N +ATOM 1435 C2 G B 45 4.559 36.986 13.277 1.00 1.00 C +ATOM 1436 N2 G B 45 5.845 37.215 13.021 1.00 1.00 N +ATOM 1437 N3 G B 45 3.613 37.539 12.512 1.00 1.00 N +ATOM 1438 C4 G B 45 2.367 37.202 12.913 1.00 1.00 C +ATOM 1439 H5' G B 45 -2.587 40.106 10.830 1.00 1.00 H +ATOM 1440 H5'' G B 45 -2.836 39.297 9.270 1.00 1.00 H +ATOM 1441 H4' G B 45 -0.534 40.051 9.433 1.00 1.00 H +ATOM 1442 H3' G B 45 -0.957 37.067 9.586 1.00 1.00 H +ATOM 1443 H2' G B 45 1.284 36.701 9.987 1.00 1.00 H +ATOM 1444 HO2' G B 45 2.846 37.808 8.998 1.00 1.00 H +ATOM 1445 H1' G B 45 1.920 39.203 11.173 1.00 1.00 H +ATOM 1446 H8 G B 45 -0.866 37.168 12.836 1.00 1.00 H +ATOM 1447 H1 G B 45 5.056 35.786 14.884 1.00 1.00 H +ATOM 1448 H21 G B 45 6.554 36.799 13.598 1.00 1.00 H +ATOM 1449 H22 G B 45 6.107 37.808 12.245 1.00 1.00 H +ATOM 1450 P G B 46 -0.437 36.890 6.871 1.00 1.00 P +ATOM 1451 OP1 G B 46 -0.599 37.423 5.500 1.00 1.00 O +ATOM 1452 OP2 G B 46 -1.421 35.922 7.406 1.00 1.00 O +ATOM 1453 O5' G B 46 1.030 36.231 6.986 1.00 1.00 O +ATOM 1454 C5' G B 46 2.188 36.949 6.547 1.00 1.00 C +ATOM 1455 C4' G B 46 3.478 36.202 6.887 1.00 1.00 C +ATOM 1456 O4' G B 46 3.536 35.924 8.284 1.00 1.00 O +ATOM 1457 C3' G B 46 3.630 34.865 6.179 1.00 1.00 C +ATOM 1458 O3' G B 46 4.312 35.054 4.933 1.00 1.00 O +ATOM 1459 C2' G B 46 4.499 34.052 7.126 1.00 1.00 C +ATOM 1460 O2' G B 46 5.873 34.077 6.723 1.00 1.00 O +ATOM 1461 C1' G B 46 4.298 34.724 8.485 1.00 1.00 C +ATOM 1462 N9 G B 46 3.591 33.878 9.467 1.00 1.00 N +ATOM 1463 C8 G B 46 2.271 33.889 9.836 1.00 1.00 C +ATOM 1464 N7 G B 46 1.970 33.012 10.753 1.00 1.00 N +ATOM 1465 C5 G B 46 3.178 32.371 11.011 1.00 1.00 C +ATOM 1466 C6 G B 46 3.475 31.319 11.922 1.00 1.00 C +ATOM 1467 O6 G B 46 2.714 30.738 12.693 1.00 1.00 O +ATOM 1468 N1 G B 46 4.817 30.965 11.870 1.00 1.00 N +ATOM 1469 C2 G B 46 5.758 31.547 11.048 1.00 1.00 C +ATOM 1470 N2 G B 46 6.997 31.071 11.139 1.00 1.00 N +ATOM 1471 N3 G B 46 5.480 32.535 10.193 1.00 1.00 N +ATOM 1472 C4 G B 46 4.176 32.895 10.228 1.00 1.00 C +ATOM 1473 H5' G B 46 2.206 37.929 7.027 1.00 1.00 H +ATOM 1474 H5'' G B 46 2.134 37.083 5.468 1.00 1.00 H +ATOM 1475 H4' G B 46 4.326 36.835 6.627 1.00 1.00 H +ATOM 1476 H3' G B 46 2.659 34.388 6.036 1.00 1.00 H +ATOM 1477 H2' G B 46 4.129 33.028 7.170 1.00 1.00 H +ATOM 1478 HO2' G B 46 6.057 33.243 6.285 1.00 1.00 H +ATOM 1479 H1' G B 46 5.272 34.991 8.894 1.00 1.00 H +ATOM 1480 H8 G B 46 1.538 34.570 9.402 1.00 1.00 H +ATOM 1481 H1 G B 46 5.105 30.222 12.491 1.00 1.00 H +ATOM 1482 H21 G B 46 7.204 30.324 11.786 1.00 1.00 H +ATOM 1483 H22 G B 46 7.731 31.456 10.562 1.00 1.00 H +ATOM 1484 P A B 47 4.174 33.974 3.744 1.00 1.00 P +ATOM 1485 OP1 A B 47 4.451 34.659 2.461 1.00 1.00 O +ATOM 1486 OP2 A B 47 2.899 33.245 3.929 1.00 1.00 O +ATOM 1487 O5' A B 47 5.386 32.952 4.038 1.00 1.00 O +ATOM 1488 C5' A B 47 6.748 33.343 3.820 1.00 1.00 C +ATOM 1489 C4' A B 47 7.721 32.259 4.277 1.00 1.00 C +ATOM 1490 O4' A B 47 7.641 32.110 5.689 1.00 1.00 O +ATOM 1491 C3' A B 47 7.453 30.891 3.673 1.00 1.00 C +ATOM 1492 O3' A B 47 8.238 30.726 2.488 1.00 1.00 O +ATOM 1493 C2' A B 47 7.925 29.927 4.751 1.00 1.00 C +ATOM 1494 O2' A B 47 9.294 29.557 4.556 1.00 1.00 O +ATOM 1495 C1' A B 47 7.740 30.725 6.041 1.00 1.00 C +ATOM 1496 N9 A B 47 6.515 30.384 6.780 1.00 1.00 N +ATOM 1497 C8 A B 47 5.230 30.800 6.545 1.00 1.00 C +ATOM 1498 N7 A B 47 4.355 30.306 7.377 1.00 1.00 N +ATOM 1499 C5 A B 47 5.115 29.505 8.222 1.00 1.00 C +ATOM 1500 C6 A B 47 4.776 28.701 9.323 1.00 1.00 C +ATOM 1501 N6 A B 47 3.529 28.572 9.776 1.00 1.00 N +ATOM 1502 N1 A B 47 5.775 28.040 9.934 1.00 1.00 N +ATOM 1503 C2 A B 47 7.014 28.173 9.478 1.00 1.00 C +ATOM 1504 N3 A B 47 7.456 28.895 8.458 1.00 1.00 N +ATOM 1505 C4 A B 47 6.432 29.546 7.866 1.00 1.00 C +ATOM 1506 H5' A B 47 6.949 34.258 4.375 1.00 1.00 H +ATOM 1507 H5'' A B 47 6.899 33.532 2.757 1.00 1.00 H +ATOM 1508 H4' A B 47 8.733 32.566 4.022 1.00 1.00 H +ATOM 1509 H3' A B 47 6.390 30.756 3.467 1.00 1.00 H +ATOM 1510 H2' A B 47 7.282 29.045 4.765 1.00 1.00 H +ATOM 1511 HO2' A B 47 9.766 29.766 5.366 1.00 1.00 H +ATOM 1512 H1' A B 47 8.603 30.575 6.689 1.00 1.00 H +ATOM 1513 H8 A B 47 4.963 31.482 5.736 1.00 1.00 H +ATOM 1514 H61 A B 47 3.339 27.981 10.572 1.00 1.00 H +ATOM 1515 H62 A B 47 2.774 29.065 9.321 1.00 1.00 H +ATOM 1516 H2 A B 47 7.774 27.610 10.019 1.00 1.00 H +ATOM 1517 P U B 48 7.737 29.758 1.303 1.00 1.00 P +ATOM 1518 OP1 U B 48 8.785 29.723 0.259 1.00 1.00 O +ATOM 1519 OP2 U B 48 6.353 30.141 0.947 1.00 1.00 O +ATOM 1520 O5' U B 48 7.694 28.318 2.017 1.00 1.00 O +ATOM 1521 C5' U B 48 8.902 27.660 2.411 1.00 1.00 C +ATOM 1522 C4' U B 48 8.617 26.499 3.357 1.00 1.00 C +ATOM 1523 O4' U B 48 7.899 26.975 4.485 1.00 1.00 O +ATOM 1524 C3' U B 48 7.782 25.389 2.746 1.00 1.00 C +ATOM 1525 O3' U B 48 8.650 24.395 2.189 1.00 1.00 O +ATOM 1526 C2' U B 48 7.018 24.816 3.936 1.00 1.00 C +ATOM 1527 O2' U B 48 7.676 23.660 4.469 1.00 1.00 O +ATOM 1528 C1' U B 48 6.999 25.964 4.952 1.00 1.00 C +ATOM 1529 N1 U B 48 5.675 26.605 5.106 1.00 1.00 N +ATOM 1530 C2 U B 48 4.893 26.219 6.178 1.00 1.00 C +ATOM 1531 O2 U B 48 5.265 25.371 6.985 1.00 1.00 O +ATOM 1532 N3 U B 48 3.665 26.845 6.289 1.00 1.00 N +ATOM 1533 C4 U B 48 3.158 27.809 5.434 1.00 1.00 C +ATOM 1534 O4 U B 48 2.049 28.300 5.631 1.00 1.00 O +ATOM 1535 C5 U B 48 4.042 28.151 4.343 1.00 1.00 C +ATOM 1536 C6 U B 48 5.251 27.551 4.214 1.00 1.00 C +ATOM 1537 H5' U B 48 9.553 28.377 2.913 1.00 1.00 H +ATOM 1538 H5'' U B 48 9.406 27.281 1.523 1.00 1.00 H +ATOM 1539 H4' U B 48 9.562 26.084 3.701 1.00 1.00 H +ATOM 1540 H3' U B 48 7.095 25.785 1.995 1.00 1.00 H +ATOM 1541 H2' U B 48 5.996 24.572 3.635 1.00 1.00 H +ATOM 1542 HO2' U B 48 8.614 23.758 4.294 1.00 1.00 H +ATOM 1543 H1' U B 48 7.342 25.596 5.920 1.00 1.00 H +ATOM 1544 H3 U B 48 3.083 26.573 7.068 1.00 1.00 H +ATOM 1545 H5 U B 48 3.734 28.901 3.616 1.00 1.00 H +ATOM 1546 H6 U B 48 5.899 27.828 3.381 1.00 1.00 H +ATOM 1547 P A B 49 8.455 23.901 0.669 1.00 1.00 P +ATOM 1548 OP1 A B 49 9.774 23.476 0.149 1.00 1.00 O +ATOM 1549 OP2 A B 49 7.673 24.927 -0.055 1.00 1.00 O +ATOM 1550 O5' A B 49 7.536 22.593 0.836 1.00 1.00 O +ATOM 1551 C5' A B 49 8.100 21.289 0.684 1.00 1.00 C +ATOM 1552 C4' A B 49 8.326 20.614 2.033 1.00 1.00 C +ATOM 1553 O4' A B 49 7.325 21.055 2.953 1.00 1.00 O +ATOM 1554 C3' A B 49 8.279 19.089 1.977 1.00 1.00 C +ATOM 1555 O3' A B 49 9.363 18.553 2.744 1.00 1.00 O +ATOM 1556 C2' A B 49 6.953 18.718 2.630 1.00 1.00 C +ATOM 1557 O2' A B 49 7.084 17.544 3.440 1.00 1.00 O +ATOM 1558 C1' A B 49 6.605 19.936 3.476 1.00 1.00 C +ATOM 1559 N9 A B 49 5.171 20.290 3.466 1.00 1.00 N +ATOM 1560 C8 A B 49 4.471 20.992 2.519 1.00 1.00 C +ATOM 1561 N7 A B 49 3.210 21.158 2.810 1.00 1.00 N +ATOM 1562 C5 A B 49 3.066 20.521 4.039 1.00 1.00 C +ATOM 1563 C6 A B 49 1.965 20.339 4.890 1.00 1.00 C +ATOM 1564 N6 A B 49 0.745 20.805 4.619 1.00 1.00 N +ATOM 1565 N1 A B 49 2.173 19.658 6.030 1.00 1.00 N +ATOM 1566 C2 A B 49 3.389 19.196 6.296 1.00 1.00 C +ATOM 1567 N3 A B 49 4.498 19.302 5.580 1.00 1.00 N +ATOM 1568 C4 A B 49 4.256 19.989 4.444 1.00 1.00 C +ATOM 1569 H5' A B 49 9.055 21.374 0.164 1.00 1.00 H +ATOM 1570 H5'' A B 49 7.425 20.676 0.088 1.00 1.00 H +ATOM 1571 H4' A B 49 9.299 20.920 2.415 1.00 1.00 H +ATOM 1572 H3' A B 49 8.314 18.736 0.944 1.00 1.00 H +ATOM 1573 H2' A B 49 6.190 18.571 1.862 1.00 1.00 H +ATOM 1574 HO2' A B 49 7.631 16.923 2.955 1.00 1.00 H +ATOM 1575 H1' A B 49 6.920 19.759 4.502 1.00 1.00 H +ATOM 1576 H8 A B 49 4.926 21.373 1.603 1.00 1.00 H +ATOM 1577 H61 A B 49 -0.010 20.643 5.271 1.00 1.00 H +ATOM 1578 H62 A B 49 0.572 21.320 3.762 1.00 1.00 H +ATOM 1579 H2 A B 49 3.488 18.651 7.235 1.00 1.00 H +ATOM 1580 P U B 50 9.866 17.042 2.501 1.00 1.00 P +ATOM 1581 OP1 U B 50 11.339 17.013 2.646 1.00 1.00 O +ATOM 1582 OP2 U B 50 9.239 16.540 1.258 1.00 1.00 O +ATOM 1583 O5' U B 50 9.220 16.251 3.744 1.00 1.00 O +ATOM 1584 C5' U B 50 10.011 15.924 4.891 1.00 1.00 C +ATOM 1585 C4' U B 50 9.192 16.007 6.177 1.00 1.00 C +ATOM 1586 O4' U B 50 9.329 17.312 6.746 1.00 1.00 O +ATOM 1587 C3' U B 50 7.696 15.746 5.975 1.00 1.00 C +ATOM 1588 O3' U B 50 7.282 14.655 6.799 1.00 1.00 O +ATOM 1589 C2' U B 50 7.009 17.022 6.448 1.00 1.00 C +ATOM 1590 O2' U B 50 5.847 16.738 7.235 1.00 1.00 O +ATOM 1591 C1' U B 50 8.070 17.717 7.277 1.00 1.00 C +ATOM 1592 N1 U B 50 7.997 19.193 7.227 1.00 1.00 N +ATOM 1593 C2 U B 50 9.180 19.891 7.361 1.00 1.00 C +ATOM 1594 O2 U B 50 10.260 19.325 7.514 1.00 1.00 O +ATOM 1595 N3 U B 50 9.080 21.270 7.315 1.00 1.00 N +ATOM 1596 C4 U B 50 7.915 21.999 7.149 1.00 1.00 C +ATOM 1597 O4 U B 50 7.943 23.228 7.121 1.00 1.00 O +ATOM 1598 C5 U B 50 6.727 21.186 7.018 1.00 1.00 C +ATOM 1599 C6 U B 50 6.800 19.835 7.060 1.00 1.00 C +ATOM 1600 H5' U B 50 10.849 16.618 4.956 1.00 1.00 H +ATOM 1601 H5'' U B 50 10.398 14.911 4.779 1.00 1.00 H +ATOM 1602 H4' U B 50 9.580 15.279 6.886 1.00 1.00 H +ATOM 1603 H3' U B 50 7.471 15.554 4.924 1.00 1.00 H +ATOM 1604 H2' U B 50 6.751 17.644 5.588 1.00 1.00 H +ATOM 1605 HO2' U B 50 5.861 17.333 7.989 1.00 1.00 H +ATOM 1606 H1' U B 50 7.992 17.388 8.313 1.00 1.00 H +ATOM 1607 H3 U B 50 9.938 21.794 7.411 1.00 1.00 H +ATOM 1608 H5 U B 50 5.758 21.669 6.882 1.00 1.00 H +ATOM 1609 H6 U B 50 5.887 19.246 6.959 1.00 1.00 H +ATOM 1610 P G B 51 5.977 13.797 6.410 1.00 1.00 P +ATOM 1611 OP1 G B 51 5.624 12.939 7.562 1.00 1.00 O +ATOM 1612 OP2 G B 51 6.203 13.188 5.079 1.00 1.00 O +ATOM 1613 O5' G B 51 4.841 14.930 6.259 1.00 1.00 O +ATOM 1614 C5' G B 51 3.864 15.120 7.286 1.00 1.00 C +ATOM 1615 C4' G B 51 2.449 14.983 6.735 1.00 1.00 C +ATOM 1616 O4' G B 51 2.021 16.238 6.192 1.00 1.00 O +ATOM 1617 C3' G B 51 2.333 13.940 5.631 1.00 1.00 C +ATOM 1618 O3' G B 51 1.763 12.738 6.158 1.00 1.00 O +ATOM 1619 C2' G B 51 1.373 14.557 4.627 1.00 1.00 C +ATOM 1620 O2' G B 51 0.036 14.105 4.838 1.00 1.00 O +ATOM 1621 C1' G B 51 1.488 16.047 4.875 1.00 1.00 C +ATOM 1622 N9 G B 51 2.380 16.729 3.925 1.00 1.00 N +ATOM 1623 C8 G B 51 3.695 17.074 4.094 1.00 1.00 C +ATOM 1624 N7 G B 51 4.224 17.668 3.062 1.00 1.00 N +ATOM 1625 C5 G B 51 3.185 17.723 2.138 1.00 1.00 C +ATOM 1626 C6 G B 51 3.166 18.260 0.821 1.00 1.00 C +ATOM 1627 O6 G B 51 4.080 18.803 0.205 1.00 1.00 O +ATOM 1628 N1 G B 51 1.919 18.111 0.229 1.00 1.00 N +ATOM 1629 C2 G B 51 0.826 17.520 0.825 1.00 1.00 C +ATOM 1630 N2 G B 51 -0.288 17.470 0.095 1.00 1.00 N +ATOM 1631 N3 G B 51 0.841 17.013 2.063 1.00 1.00 N +ATOM 1632 C4 G B 51 2.051 17.149 2.656 1.00 1.00 C +ATOM 1633 H5' G B 51 3.985 16.114 7.717 1.00 1.00 H +ATOM 1634 H5'' G B 51 4.018 14.373 8.064 1.00 1.00 H +ATOM 1635 H4' G B 51 1.778 14.711 7.549 1.00 1.00 H +ATOM 1636 H3' G B 51 3.305 13.751 5.175 1.00 1.00 H +ATOM 1637 H2' G B 51 1.707 14.332 3.615 1.00 1.00 H +ATOM 1638 HO2' G B 51 -0.015 13.205 4.509 1.00 1.00 H +ATOM 1639 H1' G B 51 0.497 16.498 4.817 1.00 1.00 H +ATOM 1640 H8 G B 51 4.249 16.872 5.012 1.00 1.00 H +ATOM 1641 H1 G B 51 1.828 18.471 -0.710 1.00 1.00 H +ATOM 1642 H21 G B 51 -0.292 17.849 -0.836 1.00 1.00 H +ATOM 1643 H22 G B 51 -1.120 17.050 0.471 1.00 1.00 H +ATOM 1644 P G B 52 1.380 11.508 5.187 1.00 1.00 P +ATOM 1645 OP1 G B 52 0.450 12.006 4.151 1.00 1.00 O +ATOM 1646 OP2 G B 52 0.979 10.366 6.039 1.00 1.00 O +ATOM 1647 O5' G B 52 2.793 11.139 4.492 1.00 1.00 O +ATOM 1648 C5' G B 52 3.131 11.591 3.170 1.00 1.00 C +ATOM 1649 C4' G B 52 1.983 11.385 2.181 1.00 1.00 C +ATOM 1650 O4' G B 52 1.383 12.650 1.882 1.00 1.00 O +ATOM 1651 C3' G B 52 2.390 10.747 0.855 1.00 1.00 C +ATOM 1652 O3' G B 52 2.097 9.348 0.898 1.00 1.00 O +ATOM 1653 C2' G B 52 1.493 11.429 -0.166 1.00 1.00 C +ATOM 1654 O2' G B 52 0.284 10.689 -0.375 1.00 1.00 O +ATOM 1655 C1' G B 52 1.213 12.784 0.466 1.00 1.00 C +ATOM 1656 N9 G B 52 2.119 13.853 0.009 1.00 1.00 N +ATOM 1657 C8 G B 52 3.046 14.562 0.729 1.00 1.00 C +ATOM 1658 N7 G B 52 3.703 15.440 0.025 1.00 1.00 N +ATOM 1659 C5 G B 52 3.174 15.307 -1.255 1.00 1.00 C +ATOM 1660 C6 G B 52 3.497 16.004 -2.452 1.00 1.00 C +ATOM 1661 O6 G B 52 4.331 16.893 -2.617 1.00 1.00 O +ATOM 1662 N1 G B 52 2.728 15.564 -3.522 1.00 1.00 N +ATOM 1663 C2 G B 52 1.768 14.578 -3.452 1.00 1.00 C +ATOM 1664 N2 G B 52 1.132 14.292 -4.587 1.00 1.00 N +ATOM 1665 N3 G B 52 1.463 13.921 -2.328 1.00 1.00 N +ATOM 1666 C4 G B 52 2.203 14.337 -1.275 1.00 1.00 C +ATOM 1667 H5' G B 52 4.005 11.039 2.825 1.00 1.00 H +ATOM 1668 H5'' G B 52 3.378 12.649 3.210 1.00 1.00 H +ATOM 1669 H4' G B 52 1.232 10.756 2.652 1.00 1.00 H +ATOM 1670 H3' G B 52 3.444 10.929 0.633 1.00 1.00 H +ATOM 1671 H2' G B 52 2.030 11.564 -1.108 1.00 1.00 H +ATOM 1672 HO2' G B 52 -0.430 11.190 0.025 1.00 1.00 H +ATOM 1673 H1' G B 52 0.185 13.074 0.255 1.00 1.00 H +ATOM 1674 H8 G B 52 3.218 14.406 1.795 1.00 1.00 H +ATOM 1675 H1 G B 52 2.900 16.015 -4.409 1.00 1.00 H +ATOM 1676 H21 G B 52 1.364 14.790 -5.436 1.00 1.00 H +ATOM 1677 H22 G B 52 0.417 13.578 -4.601 1.00 1.00 H +ATOM 1678 P A B 53 3.277 8.263 0.774 1.00 1.00 P +ATOM 1679 OP1 A B 53 2.839 7.022 1.451 1.00 1.00 O +ATOM 1680 OP2 A B 53 4.547 8.913 1.173 1.00 1.00 O +ATOM 1681 O5' A B 53 3.326 7.983 -0.808 1.00 1.00 O +ATOM 1682 C5' A B 53 2.184 7.450 -1.482 1.00 1.00 C +ATOM 1683 C4' A B 53 2.251 7.704 -2.985 1.00 1.00 C +ATOM 1684 O4' A B 53 2.204 9.101 -3.247 1.00 1.00 O +ATOM 1685 C3' A B 53 3.514 7.188 -3.650 1.00 1.00 C +ATOM 1686 O3' A B 53 3.318 5.831 -4.066 1.00 1.00 O +ATOM 1687 C2' A B 53 3.676 8.097 -4.859 1.00 1.00 C +ATOM 1688 O2' A B 53 3.108 7.508 -6.036 1.00 1.00 O +ATOM 1689 C1' A B 53 2.925 9.370 -4.456 1.00 1.00 C +ATOM 1690 N9 A B 53 3.803 10.525 -4.200 1.00 1.00 N +ATOM 1691 C8 A B 53 4.361 10.941 -3.018 1.00 1.00 C +ATOM 1692 N7 A B 53 5.098 12.012 -3.131 1.00 1.00 N +ATOM 1693 C5 A B 53 5.020 12.329 -4.484 1.00 1.00 C +ATOM 1694 C6 A B 53 5.583 13.362 -5.252 1.00 1.00 C +ATOM 1695 N6 A B 53 6.369 14.309 -4.738 1.00 1.00 N +ATOM 1696 N1 A B 53 5.301 13.377 -6.566 1.00 1.00 N +ATOM 1697 C2 A B 53 4.518 12.432 -7.071 1.00 1.00 C +ATOM 1698 N3 A B 53 3.933 11.415 -6.457 1.00 1.00 N +ATOM 1699 C4 A B 53 4.233 11.427 -5.142 1.00 1.00 C +ATOM 1700 H5' A B 53 1.284 7.918 -1.081 1.00 1.00 H +ATOM 1701 H5'' A B 53 2.136 6.376 -1.306 1.00 1.00 H +ATOM 1702 H4' A B 53 1.388 7.239 -3.457 1.00 1.00 H +ATOM 1703 H3' A B 53 4.371 7.279 -2.979 1.00 1.00 H +ATOM 1704 H2' A B 53 4.734 8.323 -5.013 1.00 1.00 H +ATOM 1705 HO2' A B 53 3.661 7.762 -6.777 1.00 1.00 H +ATOM 1706 H1' A B 53 2.218 9.632 -5.242 1.00 1.00 H +ATOM 1707 H8 A B 53 4.207 10.423 -2.071 1.00 1.00 H +ATOM 1708 H61 A B 53 6.751 15.033 -5.336 1.00 1.00 H +ATOM 1709 H62 A B 53 6.585 14.304 -3.752 1.00 1.00 H +ATOM 1710 H2 A B 53 4.331 12.504 -8.143 1.00 1.00 H +ATOM 1711 P A B 54 4.577 4.864 -4.343 1.00 1.00 P +ATOM 1712 OP1 A B 54 4.075 3.479 -4.487 1.00 1.00 O +ATOM 1713 OP2 A B 54 5.625 5.168 -3.345 1.00 1.00 O +ATOM 1714 O5' A B 54 5.093 5.365 -5.784 1.00 1.00 O +ATOM 1715 C5' A B 54 4.244 5.266 -6.930 1.00 1.00 C +ATOM 1716 C4' A B 54 4.690 6.206 -8.046 1.00 1.00 C +ATOM 1717 O4' A B 54 4.875 7.524 -7.530 1.00 1.00 O +ATOM 1718 C3' A B 54 6.008 5.816 -8.691 1.00 1.00 C +ATOM 1719 O3' A B 54 5.769 4.951 -9.808 1.00 1.00 O +ATOM 1720 C2' A B 54 6.568 7.136 -9.182 1.00 1.00 C +ATOM 1721 O2' A B 54 6.241 7.358 -10.559 1.00 1.00 O +ATOM 1722 C1' A B 54 5.903 8.178 -8.285 1.00 1.00 C +ATOM 1723 N9 A B 54 6.838 8.812 -7.342 1.00 1.00 N +ATOM 1724 C8 A B 54 7.325 8.340 -6.151 1.00 1.00 C +ATOM 1725 N7 A B 54 8.169 9.146 -5.569 1.00 1.00 N +ATOM 1726 C5 A B 54 8.245 10.230 -6.438 1.00 1.00 C +ATOM 1727 C6 A B 54 8.975 11.429 -6.397 1.00 1.00 C +ATOM 1728 N6 A B 54 9.805 11.743 -5.401 1.00 1.00 N +ATOM 1729 N1 A B 54 8.816 12.284 -7.421 1.00 1.00 N +ATOM 1730 C2 A B 54 7.991 11.962 -8.410 1.00 1.00 C +ATOM 1731 N3 A B 54 7.255 10.872 -8.564 1.00 1.00 N +ATOM 1732 C4 A B 54 7.437 10.035 -7.521 1.00 1.00 C +ATOM 1733 H5' A B 54 3.221 5.514 -6.641 1.00 1.00 H +ATOM 1734 H5'' A B 54 4.270 4.243 -7.303 1.00 1.00 H +ATOM 1735 H4' A B 54 3.916 6.238 -8.811 1.00 1.00 H +ATOM 1736 H3' A B 54 6.678 5.355 -7.964 1.00 1.00 H +ATOM 1737 H2' A B 54 7.653 7.158 -9.038 1.00 1.00 H +ATOM 1738 HO2' A B 54 5.527 6.754 -10.781 1.00 1.00 H +ATOM 1739 H1' A B 54 5.456 8.951 -8.909 1.00 1.00 H +ATOM 1740 H8 A B 54 7.034 7.377 -5.728 1.00 1.00 H +ATOM 1741 H61 A B 54 10.305 12.614 -5.420 1.00 1.00 H +ATOM 1742 H62 A B 54 9.935 11.109 -4.633 1.00 1.00 H +ATOM 1743 H2 A B 54 7.910 12.699 -9.209 1.00 1.00 H +ATOM 1744 P G B 55 6.987 4.158 -10.504 1.00 1.00 P +ATOM 1745 OP1 G B 55 6.415 3.136 -11.410 1.00 1.00 O +ATOM 1746 OP2 G B 55 7.937 3.752 -9.445 1.00 1.00 O +ATOM 1747 O5' G B 55 7.694 5.293 -11.407 1.00 1.00 O +ATOM 1748 C5' G B 55 7.178 5.625 -12.702 1.00 1.00 C +ATOM 1749 C4' G B 55 8.228 6.319 -13.571 1.00 1.00 C +ATOM 1750 O4' G B 55 8.142 7.743 -13.408 1.00 1.00 O +ATOM 1751 C3' G B 55 9.661 5.906 -13.245 1.00 1.00 C +ATOM 1752 O3' G B 55 10.093 4.877 -14.146 1.00 1.00 O +ATOM 1753 C2' G B 55 10.461 7.172 -13.488 1.00 1.00 C +ATOM 1754 O2' G B 55 10.930 7.242 -14.839 1.00 1.00 O +ATOM 1755 C1' G B 55 9.456 8.277 -13.190 1.00 1.00 C +ATOM 1756 N9 G B 55 9.500 8.768 -11.805 1.00 1.00 N +ATOM 1757 C8 G B 55 8.491 8.780 -10.876 1.00 1.00 C +ATOM 1758 N7 G B 55 8.842 9.272 -9.722 1.00 1.00 N +ATOM 1759 C5 G B 55 10.181 9.612 -9.895 1.00 1.00 C +ATOM 1760 C6 G B 55 11.099 10.193 -8.979 1.00 1.00 C +ATOM 1761 O6 G B 55 10.905 10.531 -7.812 1.00 1.00 O +ATOM 1762 N1 G B 55 12.350 10.369 -9.554 1.00 1.00 N +ATOM 1763 C2 G B 55 12.680 10.030 -10.848 1.00 1.00 C +ATOM 1764 N2 G B 55 13.937 10.272 -11.218 1.00 1.00 N +ATOM 1765 N3 G B 55 11.819 9.485 -11.712 1.00 1.00 N +ATOM 1766 C4 G B 55 10.592 9.305 -11.168 1.00 1.00 C +ATOM 1767 H5' G B 55 6.323 6.287 -12.583 1.00 1.00 H +ATOM 1768 H5'' G B 55 6.852 4.710 -13.200 1.00 1.00 H +ATOM 1769 H4' G B 55 8.027 6.084 -14.614 1.00 1.00 H +ATOM 1770 H3' G B 55 9.745 5.586 -12.205 1.00 1.00 H +ATOM 1771 H2' G B 55 11.292 7.230 -12.785 1.00 1.00 H +ATOM 1772 HO2' G B 55 10.367 6.669 -15.367 1.00 1.00 H +ATOM 1773 H1' G B 55 9.621 9.116 -13.866 1.00 1.00 H +ATOM 1774 H8 G B 55 7.488 8.407 -11.083 1.00 1.00 H +ATOM 1775 H1 G B 55 13.058 10.780 -8.962 1.00 1.00 H +ATOM 1776 H21 G B 55 14.587 10.686 -10.561 1.00 1.00 H +ATOM 1777 H22 G B 55 14.240 10.045 -12.154 1.00 1.00 H +ATOM 1778 P A B 56 10.853 3.564 -13.590 1.00 1.00 P +ATOM 1779 OP1 A B 56 10.635 2.462 -14.553 1.00 1.00 O +ATOM 1780 OP2 A B 56 10.488 3.383 -12.167 1.00 1.00 O +ATOM 1781 O5' A B 56 12.406 3.991 -13.661 1.00 1.00 O +ATOM 1782 C5' A B 56 13.057 4.179 -14.922 1.00 1.00 C +ATOM 1783 C4' A B 56 14.402 4.881 -14.760 1.00 1.00 C +ATOM 1784 O4' A B 56 14.194 6.195 -14.235 1.00 1.00 O +ATOM 1785 C3' A B 56 15.368 4.167 -13.819 1.00 1.00 C +ATOM 1786 O3' A B 56 16.262 3.343 -14.577 1.00 1.00 O +ATOM 1787 C2' A B 56 16.136 5.306 -13.172 1.00 1.00 C +ATOM 1788 O2' A B 56 17.310 5.640 -13.920 1.00 1.00 O +ATOM 1789 C1' A B 56 15.124 6.443 -13.174 1.00 1.00 C +ATOM 1790 N9 A B 56 14.355 6.547 -11.926 1.00 1.00 N +ATOM 1791 C8 A B 56 13.165 5.954 -11.592 1.00 1.00 C +ATOM 1792 N7 A B 56 12.748 6.246 -10.390 1.00 1.00 N +ATOM 1793 C5 A B 56 13.734 7.094 -9.894 1.00 1.00 C +ATOM 1794 C6 A B 56 13.886 7.755 -8.664 1.00 1.00 C +ATOM 1795 N6 A B 56 13.003 7.656 -7.669 1.00 1.00 N +ATOM 1796 N1 A B 56 14.981 8.517 -8.503 1.00 1.00 N +ATOM 1797 C2 A B 56 15.856 8.609 -9.497 1.00 1.00 C +ATOM 1798 N3 A B 56 15.827 8.040 -10.694 1.00 1.00 N +ATOM 1799 C4 A B 56 14.716 7.283 -10.824 1.00 1.00 C +ATOM 1800 H5' A B 56 12.417 4.778 -15.568 1.00 1.00 H +ATOM 1801 H5'' A B 56 13.217 3.204 -15.387 1.00 1.00 H +ATOM 1802 H4' A B 56 14.869 4.976 -15.738 1.00 1.00 H +ATOM 1803 H3' A B 56 14.826 3.587 -13.071 1.00 1.00 H +ATOM 1804 H2' A B 56 16.393 5.043 -12.145 1.00 1.00 H +ATOM 1805 HO2' A B 56 18.043 5.155 -13.529 1.00 1.00 H +ATOM 1806 H1' A B 56 15.636 7.390 -13.354 1.00 1.00 H +ATOM 1807 H8 A B 56 12.617 5.297 -12.268 1.00 1.00 H +ATOM 1808 H61 A B 56 13.159 8.155 -6.799 1.00 1.00 H +ATOM 1809 H62 A B 56 12.178 7.086 -7.781 1.00 1.00 H +ATOM 1810 H2 A B 56 16.722 9.242 -9.301 1.00 1.00 H +ATOM 1811 P A B 57 16.614 1.845 -14.089 1.00 1.00 P +ATOM 1812 OP1 A B 57 17.321 1.156 -15.192 1.00 1.00 O +ATOM 1813 OP2 A B 57 15.387 1.248 -13.516 1.00 1.00 O +ATOM 1814 O5' A B 57 17.663 2.086 -12.891 1.00 1.00 O +ATOM 1815 C5' A B 57 19.050 2.317 -13.169 1.00 1.00 C +ATOM 1816 C4' A B 57 19.850 2.532 -11.888 1.00 1.00 C +ATOM 1817 O4' A B 57 19.430 3.739 -11.252 1.00 1.00 O +ATOM 1818 C3' A B 57 19.696 1.411 -10.868 1.00 1.00 C +ATOM 1819 O3' A B 57 20.751 0.455 -11.033 1.00 1.00 O +ATOM 1820 C2' A B 57 19.842 2.126 -9.535 1.00 1.00 C +ATOM 1821 O2' A B 57 21.204 2.157 -9.099 1.00 1.00 O +ATOM 1822 C1' A B 57 19.321 3.527 -9.836 1.00 1.00 C +ATOM 1823 N9 A B 57 17.908 3.721 -9.473 1.00 1.00 N +ATOM 1824 C8 A B 57 16.791 3.419 -10.208 1.00 1.00 C +ATOM 1825 N7 A B 57 15.671 3.725 -9.615 1.00 1.00 N +ATOM 1826 C5 A B 57 16.075 4.269 -8.400 1.00 1.00 C +ATOM 1827 C6 A B 57 15.359 4.790 -7.308 1.00 1.00 C +ATOM 1828 N6 A B 57 14.028 4.849 -7.269 1.00 1.00 N +ATOM 1829 N1 A B 57 16.073 5.244 -6.265 1.00 1.00 N +ATOM 1830 C2 A B 57 17.399 5.182 -6.310 1.00 1.00 C +ATOM 1831 N3 A B 57 18.182 4.719 -7.272 1.00 1.00 N +ATOM 1832 C4 A B 57 17.437 4.270 -8.305 1.00 1.00 C +ATOM 1833 H5' A B 57 19.145 3.200 -13.799 1.00 1.00 H +ATOM 1834 H5'' A B 57 19.453 1.455 -13.702 1.00 1.00 H +ATOM 1835 H4' A B 57 20.903 2.630 -12.144 1.00 1.00 H +ATOM 1836 H3' A B 57 18.714 0.942 -10.953 1.00 1.00 H +ATOM 1837 H2' A B 57 19.206 1.655 -8.789 1.00 1.00 H +ATOM 1838 HO2' A B 57 21.246 2.734 -8.333 1.00 1.00 H +ATOM 1839 H1' A B 57 19.929 4.263 -9.312 1.00 1.00 H +ATOM 1840 H8 A B 57 16.834 2.963 -11.198 1.00 1.00 H +ATOM 1841 H61 A B 57 13.566 5.233 -6.459 1.00 1.00 H +ATOM 1842 H62 A B 57 13.484 4.510 -8.048 1.00 1.00 H +ATOM 1843 H2 A B 57 17.915 5.567 -5.430 1.00 1.00 H +ATOM 1844 P C B 58 20.520 -1.100 -10.667 1.00 1.00 P +ATOM 1845 OP1 C B 58 21.746 -1.845 -11.031 1.00 1.00 O +ATOM 1846 OP2 C B 58 19.213 -1.518 -11.222 1.00 1.00 O +ATOM 1847 O5' C B 58 20.401 -1.087 -9.061 1.00 1.00 O +ATOM 1848 C5' C B 58 21.574 -1.051 -8.243 1.00 1.00 C +ATOM 1849 C4' C B 58 21.219 -0.924 -6.765 1.00 1.00 C +ATOM 1850 O4' C B 58 20.455 0.255 -6.549 1.00 1.00 O +ATOM 1851 C3' C B 58 20.385 -2.069 -6.218 1.00 1.00 C +ATOM 1852 O3' C B 58 21.243 -3.118 -5.748 1.00 1.00 O +ATOM 1853 C2' C B 58 19.640 -1.430 -5.052 1.00 1.00 C +ATOM 1854 O2' C B 58 20.327 -1.641 -3.812 1.00 1.00 O +ATOM 1855 C1' C B 58 19.589 0.056 -5.422 1.00 1.00 C +ATOM 1856 N1 C B 58 18.243 0.531 -5.811 1.00 1.00 N +ATOM 1857 C2 C B 58 17.478 1.167 -4.845 1.00 1.00 C +ATOM 1858 O2 C B 58 17.929 1.331 -3.713 1.00 1.00 O +ATOM 1859 N3 C B 58 16.231 1.595 -5.187 1.00 1.00 N +ATOM 1860 C4 C B 58 15.756 1.408 -6.427 1.00 1.00 C +ATOM 1861 N4 C B 58 14.531 1.837 -6.729 1.00 1.00 N +ATOM 1862 C5 C B 58 16.543 0.756 -7.427 1.00 1.00 C +ATOM 1863 C6 C B 58 17.775 0.336 -7.077 1.00 1.00 C +ATOM 1864 H5' C B 58 22.191 -0.201 -8.537 1.00 1.00 H +ATOM 1865 H5'' C B 58 22.141 -1.971 -8.395 1.00 1.00 H +ATOM 1866 H4' C B 58 22.138 -0.848 -6.187 1.00 1.00 H +ATOM 1867 H3' C B 58 19.687 -2.434 -6.973 1.00 1.00 H +ATOM 1868 H2' C B 58 18.630 -1.825 -5.003 1.00 1.00 H +ATOM 1869 HO2' C B 58 20.900 -0.885 -3.671 1.00 1.00 H +ATOM 1870 H1' C B 58 19.949 0.645 -4.583 1.00 1.00 H +ATOM 1871 H41 C B 58 13.976 2.298 -6.032 1.00 1.00 H +ATOM 1872 H42 C B 58 14.163 1.704 -7.660 1.00 1.00 H +ATOM 1873 H5 C B 58 16.162 0.608 -8.436 1.00 1.00 H +ATOM 1874 H6 C B 58 18.404 -0.164 -7.814 1.00 1.00 H +ATOM 1875 P C B 59 20.685 -4.623 -5.579 1.00 1.00 P +ATOM 1876 OP1 C B 59 21.816 -5.499 -5.202 1.00 1.00 O +ATOM 1877 OP2 C B 59 19.860 -4.948 -6.764 1.00 1.00 O +ATOM 1878 O5' C B 59 19.709 -4.483 -4.308 1.00 1.00 O +ATOM 1879 C5' C B 59 20.240 -4.109 -3.037 1.00 1.00 C +ATOM 1880 C4' C B 59 19.160 -3.538 -2.120 1.00 1.00 C +ATOM 1881 O4' C B 59 18.436 -2.522 -2.810 1.00 1.00 O +ATOM 1882 C3' C B 59 18.122 -4.545 -1.647 1.00 1.00 C +ATOM 1883 O3' C B 59 18.522 -5.081 -0.381 1.00 1.00 O +ATOM 1884 C2' C B 59 16.867 -3.713 -1.448 1.00 1.00 C +ATOM 1885 O2' C B 59 16.679 -3.378 -0.070 1.00 1.00 O +ATOM 1886 C1' C B 59 17.096 -2.465 -2.295 1.00 1.00 C +ATOM 1887 N1 C B 59 16.145 -2.320 -3.424 1.00 1.00 N +ATOM 1888 C2 C B 59 15.029 -1.529 -3.203 1.00 1.00 C +ATOM 1889 O2 C B 59 14.858 -0.996 -2.110 1.00 1.00 O +ATOM 1890 N3 C B 59 14.139 -1.371 -4.221 1.00 1.00 N +ATOM 1891 C4 C B 59 14.336 -1.963 -5.406 1.00 1.00 C +ATOM 1892 N4 C B 59 13.445 -1.786 -6.380 1.00 1.00 N +ATOM 1893 C5 C B 59 15.486 -2.781 -5.638 1.00 1.00 C +ATOM 1894 C6 C B 59 16.361 -2.934 -4.625 1.00 1.00 C +ATOM 1895 H5' C B 59 21.017 -3.358 -3.182 1.00 1.00 H +ATOM 1896 H5'' C B 59 20.678 -4.987 -2.563 1.00 1.00 H +ATOM 1897 H4' C B 59 19.638 -3.089 -1.251 1.00 1.00 H +ATOM 1898 H3' C B 59 17.966 -5.332 -2.387 1.00 1.00 H +ATOM 1899 H2' C B 59 16.002 -4.263 -1.830 1.00 1.00 H +ATOM 1900 HO2' C B 59 16.791 -2.429 0.011 1.00 1.00 H +ATOM 1901 H1' C B 59 17.015 -1.590 -1.649 1.00 1.00 H +ATOM 1902 H41 C B 59 12.627 -1.207 -6.221 1.00 1.00 H +ATOM 1903 H42 C B 59 13.581 -2.227 -7.278 1.00 1.00 H +ATOM 1904 H5 C B 59 15.650 -3.264 -6.602 1.00 1.00 H +ATOM 1905 H6 C B 59 17.249 -3.551 -4.765 1.00 1.00 H +ATOM 1906 P G B 60 17.700 -6.289 0.297 1.00 1.00 P +ATOM 1907 OP1 G B 60 18.624 -7.040 1.177 1.00 1.00 O +ATOM 1908 OP2 G B 60 16.952 -6.996 -0.765 1.00 1.00 O +ATOM 1909 O5' G B 60 16.636 -5.514 1.233 1.00 1.00 O +ATOM 1910 C5' G B 60 17.079 -4.758 2.369 1.00 1.00 C +ATOM 1911 C4' G B 60 15.905 -4.205 3.174 1.00 1.00 C +ATOM 1912 O4' G B 60 15.253 -3.165 2.444 1.00 1.00 O +ATOM 1913 C3' G B 60 14.841 -5.237 3.510 1.00 1.00 C +ATOM 1914 O3' G B 60 15.109 -5.824 4.786 1.00 1.00 O +ATOM 1915 C2' G B 60 13.562 -4.424 3.581 1.00 1.00 C +ATOM 1916 O2' G B 60 13.291 -3.983 4.913 1.00 1.00 O +ATOM 1917 C1' G B 60 13.835 -3.246 2.659 1.00 1.00 C +ATOM 1918 N9 G B 60 13.199 -3.383 1.346 1.00 1.00 N +ATOM 1919 C8 G B 60 13.783 -3.736 0.156 1.00 1.00 C +ATOM 1920 N7 G B 60 12.953 -3.777 -0.849 1.00 1.00 N +ATOM 1921 C5 G B 60 11.729 -3.426 -0.288 1.00 1.00 C +ATOM 1922 C6 G B 60 10.450 -3.300 -0.897 1.00 1.00 C +ATOM 1923 O6 G B 60 10.145 -3.480 -2.073 1.00 1.00 O +ATOM 1924 N1 G B 60 9.482 -2.925 0.025 1.00 1.00 N +ATOM 1925 C2 G B 60 9.711 -2.699 1.365 1.00 1.00 C +ATOM 1926 N2 G B 60 8.650 -2.348 2.092 1.00 1.00 N +ATOM 1927 N3 G B 60 10.912 -2.816 1.941 1.00 1.00 N +ATOM 1928 C4 G B 60 11.871 -3.181 1.056 1.00 1.00 C +ATOM 1929 H5' G B 60 17.693 -3.928 2.023 1.00 1.00 H +ATOM 1930 H5'' G B 60 17.679 -5.401 3.013 1.00 1.00 H +ATOM 1931 H4' G B 60 16.287 -3.781 4.100 1.00 1.00 H +ATOM 1932 H3' G B 60 14.776 -5.997 2.727 1.00 1.00 H +ATOM 1933 H2' G B 60 12.729 -5.008 3.192 1.00 1.00 H +ATOM 1934 HO2' G B 60 12.572 -3.352 4.862 1.00 1.00 H +ATOM 1935 H1' G B 60 13.488 -2.327 3.129 1.00 1.00 H +ATOM 1936 H8 G B 60 14.844 -3.964 0.060 1.00 1.00 H +ATOM 1937 H1 G B 60 8.544 -2.815 -0.336 1.00 1.00 H +ATOM 1938 H21 G B 60 7.745 -2.260 1.656 1.00 1.00 H +ATOM 1939 H22 G B 60 8.755 -2.169 3.080 1.00 1.00 H +ATOM 1940 P G B 61 14.433 -7.228 5.199 1.00 1.00 P +ATOM 1941 OP1 G B 61 14.934 -7.607 6.538 1.00 1.00 O +ATOM 1942 OP2 G B 61 14.580 -8.165 4.062 1.00 1.00 O +ATOM 1943 O5' G B 61 12.874 -6.841 5.335 1.00 1.00 O +ATOM 1944 C5' G B 61 12.440 -5.914 6.336 1.00 1.00 C +ATOM 1945 C4' G B 61 10.938 -5.655 6.255 1.00 1.00 C +ATOM 1946 O4' G B 61 10.614 -5.072 4.994 1.00 1.00 O +ATOM 1947 C3' G B 61 10.084 -6.905 6.392 1.00 1.00 C +ATOM 1948 O3' G B 61 9.715 -7.085 7.763 1.00 1.00 O +ATOM 1949 C2' G B 61 8.849 -6.593 5.559 1.00 1.00 C +ATOM 1950 O2' G B 61 7.783 -6.088 6.371 1.00 1.00 O +ATOM 1951 C1' G B 61 9.332 -5.548 4.560 1.00 1.00 C +ATOM 1952 N9 G B 61 9.494 -6.075 3.192 1.00 1.00 N +ATOM 1953 C8 G B 61 10.582 -6.699 2.640 1.00 1.00 C +ATOM 1954 N7 G B 61 10.416 -7.051 1.396 1.00 1.00 N +ATOM 1955 C5 G B 61 9.123 -6.631 1.098 1.00 1.00 C +ATOM 1956 C6 G B 61 8.385 -6.743 -0.114 1.00 1.00 C +ATOM 1957 O6 G B 61 8.738 -7.245 -1.178 1.00 1.00 O +ATOM 1958 N1 G B 61 7.118 -6.191 0.009 1.00 1.00 N +ATOM 1959 C2 G B 61 6.618 -5.603 1.152 1.00 1.00 C +ATOM 1960 N2 G B 61 5.375 -5.130 1.075 1.00 1.00 N +ATOM 1961 N3 G B 61 7.309 -5.498 2.293 1.00 1.00 N +ATOM 1962 C4 G B 61 8.550 -6.032 2.192 1.00 1.00 C +ATOM 1963 H5' G B 61 12.971 -4.971 6.200 1.00 1.00 H +ATOM 1964 H5'' G B 61 12.679 -6.318 7.320 1.00 1.00 H +ATOM 1965 H4' G B 61 10.661 -4.952 7.039 1.00 1.00 H +ATOM 1966 H3' G B 61 10.608 -7.778 6.000 1.00 1.00 H +ATOM 1967 H2' G B 61 8.531 -7.486 5.025 1.00 1.00 H +ATOM 1968 HO2' G B 61 8.109 -5.303 6.815 1.00 1.00 H +ATOM 1969 H1' G B 61 8.628 -4.718 4.538 1.00 1.00 H +ATOM 1970 H8 G B 61 11.505 -6.882 3.192 1.00 1.00 H +ATOM 1971 H1 G B 61 6.533 -6.233 -0.813 1.00 1.00 H +ATOM 1972 H21 G B 61 4.855 -5.211 0.212 1.00 1.00 H +ATOM 1973 H22 G B 61 4.953 -4.689 1.879 1.00 1.00 H +ATOM 1974 P G B 62 9.304 -8.541 8.318 1.00 1.00 P +ATOM 1975 OP1 G B 62 9.063 -8.428 9.775 1.00 1.00 O +ATOM 1976 OP2 G B 62 10.283 -9.526 7.806 1.00 1.00 O +ATOM 1977 O5' G B 62 7.892 -8.808 7.593 1.00 1.00 O +ATOM 1978 C5' G B 62 6.747 -8.008 7.905 1.00 1.00 C +ATOM 1979 C4' G B 62 5.545 -8.401 7.051 1.00 1.00 C +ATOM 1980 O4' G B 62 5.792 -8.069 5.695 1.00 1.00 O +ATOM 1981 C3' G B 62 5.218 -9.884 7.083 1.00 1.00 C +ATOM 1982 O3' G B 62 4.260 -10.137 8.117 1.00 1.00 O +ATOM 1983 C2' G B 62 4.595 -10.147 5.716 1.00 1.00 C +ATOM 1984 O2' G B 62 3.165 -10.134 5.786 1.00 1.00 O +ATOM 1985 C1' G B 62 5.124 -9.006 4.839 1.00 1.00 C +ATOM 1986 N9 G B 62 6.099 -9.431 3.819 1.00 1.00 N +ATOM 1987 C8 G B 62 7.435 -9.696 3.968 1.00 1.00 C +ATOM 1988 N7 G B 62 8.029 -10.059 2.866 1.00 1.00 N +ATOM 1989 C5 G B 62 7.013 -10.032 1.913 1.00 1.00 C +ATOM 1990 C6 G B 62 7.059 -10.333 0.524 1.00 1.00 C +ATOM 1991 O6 G B 62 8.025 -10.689 -0.149 1.00 1.00 O +ATOM 1992 N1 G B 62 5.813 -10.181 -0.070 1.00 1.00 N +ATOM 1993 C2 G B 62 4.666 -9.789 0.586 1.00 1.00 C +ATOM 1994 N2 G B 62 3.564 -9.699 -0.157 1.00 1.00 N +ATOM 1995 N3 G B 62 4.621 -9.506 1.891 1.00 1.00 N +ATOM 1996 C4 G B 62 5.827 -9.649 2.488 1.00 1.00 C +ATOM 1997 H5' G B 62 6.985 -6.959 7.723 1.00 1.00 H +ATOM 1998 H5'' G B 62 6.496 -8.140 8.957 1.00 1.00 H +ATOM 1999 H4' G B 62 4.675 -7.840 7.390 1.00 1.00 H +ATOM 2000 H3' G B 62 6.122 -10.480 7.222 1.00 1.00 H +ATOM 2001 H2' G B 62 4.951 -11.106 5.327 1.00 1.00 H +ATOM 2002 HO2' G B 62 2.905 -10.771 6.456 1.00 1.00 H +ATOM 2003 H1' G B 62 4.287 -8.512 4.346 1.00 1.00 H +ATOM 2004 H8 G B 62 7.956 -9.610 4.922 1.00 1.00 H +ATOM 2005 H1 G B 62 5.767 -10.378 -1.060 1.00 1.00 H +ATOM 2006 H21 G B 62 3.600 -9.913 -1.143 1.00 1.00 H +ATOM 2007 H22 G B 62 2.692 -9.416 0.267 1.00 1.00 H +ATOM 2008 P G B 63 4.210 -11.565 8.859 1.00 1.00 P +ATOM 2009 OP1 G B 63 2.980 -11.617 9.680 1.00 1.00 O +ATOM 2010 OP2 G B 63 5.528 -11.808 9.489 1.00 1.00 O +ATOM 2011 O5' G B 63 4.040 -12.592 7.634 1.00 1.00 O +ATOM 2012 C5' G B 63 4.747 -13.835 7.630 1.00 1.00 C +ATOM 2013 C4' G B 63 4.473 -14.633 6.360 1.00 1.00 C +ATOM 2014 O4' G B 63 4.582 -13.780 5.218 1.00 1.00 O +ATOM 2015 C3' G B 63 5.429 -15.799 6.153 1.00 1.00 C +ATOM 2016 O3' G B 63 4.807 -17.007 6.603 1.00 1.00 O +ATOM 2017 C2' G B 63 5.631 -15.851 4.647 1.00 1.00 C +ATOM 2018 O2' G B 63 4.716 -16.763 4.030 1.00 1.00 O +ATOM 2019 C1' G B 63 5.371 -14.415 4.204 1.00 1.00 C +ATOM 2020 N9 G B 63 6.593 -13.612 4.037 1.00 1.00 N +ATOM 2021 C8 G B 63 7.180 -12.763 4.940 1.00 1.00 C +ATOM 2022 N7 G B 63 8.264 -12.190 4.500 1.00 1.00 N +ATOM 2023 C5 G B 63 8.410 -12.693 3.211 1.00 1.00 C +ATOM 2024 C6 G B 63 9.414 -12.429 2.240 1.00 1.00 C +ATOM 2025 O6 G B 63 10.389 -11.687 2.332 1.00 1.00 O +ATOM 2026 N1 G B 63 9.190 -13.141 1.070 1.00 1.00 N +ATOM 2027 C2 G B 63 8.135 -14.000 0.856 1.00 1.00 C +ATOM 2028 N2 G B 63 8.091 -14.592 -0.337 1.00 1.00 N +ATOM 2029 N3 G B 63 7.188 -14.252 1.767 1.00 1.00 N +ATOM 2030 C4 G B 63 7.390 -13.565 2.918 1.00 1.00 C +ATOM 2031 H5' G B 63 4.434 -14.422 8.492 1.00 1.00 H +ATOM 2032 H5'' G B 63 5.816 -13.637 7.706 1.00 1.00 H +ATOM 2033 H4' G B 63 3.457 -15.018 6.403 1.00 1.00 H +ATOM 2034 H3' G B 63 6.376 -15.623 6.668 1.00 1.00 H +ATOM 2035 H2' G B 63 6.664 -16.127 4.421 1.00 1.00 H +ATOM 2036 HO2' G B 63 5.212 -17.269 3.382 1.00 1.00 H +ATOM 2037 H1' G B 63 4.816 -14.421 3.267 1.00 1.00 H +ATOM 2038 H8 G B 63 6.776 -12.581 5.936 1.00 1.00 H +ATOM 2039 H1 G B 63 9.865 -13.004 0.331 1.00 1.00 H +ATOM 2040 H21 G B 63 8.807 -14.400 -1.023 1.00 1.00 H +ATOM 2041 H22 G B 63 7.343 -15.232 -0.554 1.00 1.00 H +ATOM 2042 P A B 64 5.668 -18.148 7.343 1.00 1.00 P +ATOM 2043 OP1 A B 64 4.727 -19.097 7.979 1.00 1.00 O +ATOM 2044 OP2 A B 64 6.712 -17.487 8.157 1.00 1.00 O +ATOM 2045 O5' A B 64 6.389 -18.897 6.113 1.00 1.00 O +ATOM 2046 C5' A B 64 7.658 -19.536 6.288 1.00 1.00 C +ATOM 2047 C4' A B 64 8.055 -20.340 5.054 1.00 1.00 C +ATOM 2048 O4' A B 64 7.178 -21.463 4.917 1.00 1.00 O +ATOM 2049 C3' A B 64 7.990 -19.540 3.757 1.00 1.00 C +ATOM 2050 O3' A B 64 9.316 -19.179 3.354 1.00 1.00 O +ATOM 2051 C2' A B 64 7.391 -20.509 2.747 1.00 1.00 C +ATOM 2052 O2' A B 64 8.409 -21.192 2.009 1.00 1.00 O +ATOM 2053 C1' A B 64 6.590 -21.469 3.612 1.00 1.00 C +ATOM 2054 N9 A B 64 5.170 -21.096 3.761 1.00 1.00 N +ATOM 2055 C8 A B 64 4.565 -20.438 4.800 1.00 1.00 C +ATOM 2056 N7 A B 64 3.283 -20.257 4.636 1.00 1.00 N +ATOM 2057 C5 A B 64 3.021 -20.836 3.399 1.00 1.00 C +ATOM 2058 C6 A B 64 1.842 -20.975 2.649 1.00 1.00 C +ATOM 2059 N6 A B 64 0.659 -20.515 3.058 1.00 1.00 N +ATOM 2060 N1 A B 64 1.934 -21.603 1.466 1.00 1.00 N +ATOM 2061 C2 A B 64 3.116 -22.055 1.063 1.00 1.00 C +ATOM 2062 N3 A B 64 4.291 -21.987 1.674 1.00 1.00 N +ATOM 2063 C4 A B 64 4.164 -21.352 2.858 1.00 1.00 C +ATOM 2064 H5' A B 64 7.605 -20.205 7.147 1.00 1.00 H +ATOM 2065 H5'' A B 64 8.416 -18.775 6.476 1.00 1.00 H +ATOM 2066 H4' A B 64 9.068 -20.709 5.189 1.00 1.00 H +ATOM 2067 H3' A B 64 7.357 -18.657 3.873 1.00 1.00 H +ATOM 2068 H2' A B 64 6.721 -19.976 2.075 1.00 1.00 H +ATOM 2069 HO2' A B 64 9.195 -20.642 2.033 1.00 1.00 H +ATOM 2070 H1' A B 64 6.655 -22.472 3.194 1.00 1.00 H +ATOM 2071 H8 A B 64 5.104 -20.100 5.684 1.00 1.00 H +ATOM 2072 H61 A B 64 -0.160 -20.641 2.480 1.00 1.00 H +ATOM 2073 H62 A B 64 0.582 -20.042 3.946 1.00 1.00 H +ATOM 2074 H2 A B 64 3.120 -22.555 0.094 1.00 1.00 H +ATOM 2075 P A B 65 9.606 -17.743 2.684 1.00 1.00 P +ATOM 2076 OP1 A B 65 11.060 -17.635 2.429 1.00 1.00 O +ATOM 2077 OP2 A B 65 8.920 -16.711 3.492 1.00 1.00 O +ATOM 2078 O5' A B 65 8.854 -17.858 1.265 1.00 1.00 O +ATOM 2079 C5' A B 65 9.517 -18.441 0.141 1.00 1.00 C +ATOM 2080 C4' A B 65 8.577 -19.350 -0.648 1.00 1.00 C +ATOM 2081 O4' A B 65 7.526 -19.793 0.212 1.00 1.00 O +ATOM 2082 C3' A B 65 7.928 -18.680 -1.858 1.00 1.00 C +ATOM 2083 O3' A B 65 8.628 -19.057 -3.049 1.00 1.00 O +ATOM 2084 C2' A B 65 6.526 -19.263 -1.889 1.00 1.00 C +ATOM 2085 O2' A B 65 6.463 -20.422 -2.726 1.00 1.00 O +ATOM 2086 C1' A B 65 6.263 -19.607 -0.429 1.00 1.00 C +ATOM 2087 N9 A B 65 5.542 -18.554 0.302 1.00 1.00 N +ATOM 2088 C8 A B 65 6.010 -17.682 1.253 1.00 1.00 C +ATOM 2089 N7 A B 65 5.103 -16.862 1.708 1.00 1.00 N +ATOM 2090 C5 A B 65 3.952 -17.219 1.008 1.00 1.00 C +ATOM 2091 C6 A B 65 2.635 -16.728 1.028 1.00 1.00 C +ATOM 2092 N6 A B 65 2.242 -15.726 1.813 1.00 1.00 N +ATOM 2093 N1 A B 65 1.747 -17.313 0.206 1.00 1.00 N +ATOM 2094 C2 A B 65 2.146 -18.310 -0.575 1.00 1.00 C +ATOM 2095 N3 A B 65 3.346 -18.855 -0.684 1.00 1.00 N +ATOM 2096 C4 A B 65 4.214 -18.249 0.152 1.00 1.00 C +ATOM 2097 H5' A B 65 10.369 -19.024 0.491 1.00 1.00 H +ATOM 2098 H5'' A B 65 9.874 -17.645 -0.513 1.00 1.00 H +ATOM 2099 H4' A B 65 9.133 -20.223 -0.985 1.00 1.00 H +ATOM 2100 H3' A B 65 7.897 -17.596 -1.738 1.00 1.00 H +ATOM 2101 H2' A B 65 5.815 -18.506 -2.225 1.00 1.00 H +ATOM 2102 HO2' A B 65 6.542 -20.121 -3.635 1.00 1.00 H +ATOM 2103 H1' A B 65 5.692 -20.533 -0.369 1.00 1.00 H +ATOM 2104 H8 A B 65 7.047 -17.674 1.595 1.00 1.00 H +ATOM 2105 H61 A B 65 1.283 -15.411 1.789 1.00 1.00 H +ATOM 2106 H62 A B 65 2.903 -15.282 2.433 1.00 1.00 H +ATOM 2107 H2 A B 65 1.376 -18.740 -1.216 1.00 1.00 H +ATOM 2108 P A B 66 8.958 -17.965 -4.186 1.00 1.00 P +ATOM 2109 OP1 A B 66 9.608 -18.661 -5.319 1.00 1.00 O +ATOM 2110 OP2 A B 66 9.631 -16.816 -3.543 1.00 1.00 O +ATOM 2111 O5' A B 66 7.495 -17.490 -4.663 1.00 1.00 O +ATOM 2112 C5' A B 66 6.808 -18.179 -5.713 1.00 1.00 C +ATOM 2113 C4' A B 66 5.339 -17.769 -5.779 1.00 1.00 C +ATOM 2114 O4' A B 66 4.743 -17.918 -4.490 1.00 1.00 O +ATOM 2115 C3' A B 66 5.116 -16.326 -6.205 1.00 1.00 C +ATOM 2116 O3' A B 66 4.895 -16.263 -7.618 1.00 1.00 O +ATOM 2117 C2' A B 66 3.848 -15.924 -5.469 1.00 1.00 C +ATOM 2118 O2' A B 66 2.683 -16.145 -6.271 1.00 1.00 O +ATOM 2119 C1' A B 66 3.851 -16.822 -4.238 1.00 1.00 C +ATOM 2120 N9 A B 66 4.316 -16.137 -3.022 1.00 1.00 N +ATOM 2121 C8 A B 66 5.599 -15.976 -2.565 1.00 1.00 C +ATOM 2122 N7 A B 66 5.682 -15.305 -1.449 1.00 1.00 N +ATOM 2123 C5 A B 66 4.359 -15.000 -1.145 1.00 1.00 C +ATOM 2124 C6 A B 66 3.766 -14.299 -0.082 1.00 1.00 C +ATOM 2125 N6 A B 66 4.466 -13.750 0.911 1.00 1.00 N +ATOM 2126 N1 A B 66 2.429 -14.185 -0.091 1.00 1.00 N +ATOM 2127 C2 A B 66 1.738 -14.729 -1.085 1.00 1.00 C +ATOM 2128 N3 A B 66 2.177 -15.405 -2.135 1.00 1.00 N +ATOM 2129 C4 A B 66 3.521 -15.504 -2.098 1.00 1.00 C +ATOM 2130 H5' A B 66 6.873 -19.253 -5.539 1.00 1.00 H +ATOM 2131 H5'' A B 66 7.285 -17.942 -6.664 1.00 1.00 H +ATOM 2132 H4' A B 66 4.822 -18.428 -6.474 1.00 1.00 H +ATOM 2133 H3' A B 66 5.956 -15.698 -5.904 1.00 1.00 H +ATOM 2134 H2' A B 66 3.911 -14.879 -5.163 1.00 1.00 H +ATOM 2135 HO2' A B 66 2.074 -15.426 -6.092 1.00 1.00 H +ATOM 2136 H1' A B 66 2.849 -17.209 -4.069 1.00 1.00 H +ATOM 2137 H8 A B 66 6.470 -16.374 -3.086 1.00 1.00 H +ATOM 2138 H61 A B 66 3.987 -13.255 1.651 1.00 1.00 H +ATOM 2139 H62 A B 66 5.478 -13.829 0.927 1.00 1.00 H +ATOM 2140 H2 A B 66 0.658 -14.597 -1.029 1.00 1.00 H +ATOM 2141 P C B 67 5.371 -14.977 -8.461 1.00 1.00 P +ATOM 2142 OP1 C B 67 4.984 -15.178 -9.875 1.00 1.00 O +ATOM 2143 OP2 C B 67 6.782 -14.692 -8.115 1.00 1.00 O +ATOM 2144 O5' C B 67 4.455 -13.801 -7.852 1.00 1.00 O +ATOM 2145 C5' C B 67 3.033 -13.834 -7.999 1.00 1.00 C +ATOM 2146 C4' C B 67 2.341 -13.050 -6.889 1.00 1.00 C +ATOM 2147 O4' C B 67 2.815 -13.497 -5.621 1.00 1.00 O +ATOM 2148 C3' C B 67 2.579 -11.549 -6.937 1.00 1.00 C +ATOM 2149 O3' C B 67 1.545 -10.918 -7.699 1.00 1.00 O +ATOM 2150 C2' C B 67 2.473 -11.131 -5.481 1.00 1.00 C +ATOM 2151 O2' C B 67 1.137 -10.745 -5.143 1.00 1.00 O +ATOM 2152 C1' C B 67 2.902 -12.383 -4.722 1.00 1.00 C +ATOM 2153 N1 C B 67 4.288 -12.323 -4.223 1.00 1.00 N +ATOM 2154 C2 C B 67 4.483 -11.858 -2.932 1.00 1.00 C +ATOM 2155 O2 C B 67 3.520 -11.518 -2.248 1.00 1.00 O +ATOM 2156 N3 C B 67 5.757 -11.789 -2.456 1.00 1.00 N +ATOM 2157 C4 C B 67 6.796 -12.162 -3.215 1.00 1.00 C +ATOM 2158 N4 C B 67 8.031 -12.083 -2.720 1.00 1.00 N +ATOM 2159 C5 C B 67 6.599 -12.643 -4.548 1.00 1.00 C +ATOM 2160 C6 C B 67 5.334 -12.708 -5.009 1.00 1.00 C +ATOM 2161 H5' C B 67 2.695 -14.870 -7.965 1.00 1.00 H +ATOM 2162 H5'' C B 67 2.764 -13.402 -8.962 1.00 1.00 H +ATOM 2163 H4' C B 67 1.271 -13.240 -6.938 1.00 1.00 H +ATOM 2164 H3' C B 67 3.568 -11.322 -7.340 1.00 1.00 H +ATOM 2165 H2' C B 67 3.173 -10.320 -5.275 1.00 1.00 H +ATOM 2166 HO2' C B 67 0.981 -11.022 -4.237 1.00 1.00 H +ATOM 2167 H1' C B 67 2.224 -12.547 -3.886 1.00 1.00 H +ATOM 2168 H41 C B 67 8.175 -11.745 -1.781 1.00 1.00 H +ATOM 2169 H42 C B 67 8.821 -12.361 -3.284 1.00 1.00 H +ATOM 2170 H5 C B 67 7.442 -12.946 -5.169 1.00 1.00 H +ATOM 2171 H6 C B 67 5.146 -13.070 -6.020 1.00 1.00 H +ATOM 2172 P U B 68 1.794 -9.485 -8.391 1.00 1.00 P +ATOM 2173 OP1 U B 68 0.566 -9.105 -9.126 1.00 1.00 O +ATOM 2174 OP2 U B 68 3.093 -9.531 -9.098 1.00 1.00 O +ATOM 2175 O5' U B 68 1.944 -8.502 -7.124 1.00 1.00 O +ATOM 2176 C5' U B 68 0.856 -8.314 -6.216 1.00 1.00 C +ATOM 2177 C4' U B 68 1.296 -7.548 -4.970 1.00 1.00 C +ATOM 2178 O4' U B 68 2.302 -8.281 -4.282 1.00 1.00 O +ATOM 2179 C3' U B 68 1.889 -6.179 -5.252 1.00 1.00 C +ATOM 2180 O3' U B 68 0.857 -5.189 -5.233 1.00 1.00 O +ATOM 2181 C2' U B 68 2.843 -5.952 -4.089 1.00 1.00 C +ATOM 2182 O2' U B 68 2.229 -5.179 -3.052 1.00 1.00 O +ATOM 2183 C1' U B 68 3.180 -7.365 -3.610 1.00 1.00 C +ATOM 2184 N1 U B 68 4.567 -7.780 -3.911 1.00 1.00 N +ATOM 2185 C2 U B 68 5.514 -7.637 -2.915 1.00 1.00 C +ATOM 2186 O2 U B 68 5.235 -7.178 -1.809 1.00 1.00 O +ATOM 2187 N3 U B 68 6.798 -8.039 -3.235 1.00 1.00 N +ATOM 2188 C4 U B 68 7.211 -8.565 -4.448 1.00 1.00 C +ATOM 2189 O4 U B 68 8.383 -8.891 -4.623 1.00 1.00 O +ATOM 2190 C5 U B 68 6.156 -8.679 -5.430 1.00 1.00 C +ATOM 2191 C6 U B 68 4.890 -8.292 -5.139 1.00 1.00 C +ATOM 2192 H5' U B 68 0.469 -9.289 -5.916 1.00 1.00 H +ATOM 2193 H5'' U B 68 0.066 -7.756 -6.716 1.00 1.00 H +ATOM 2194 H4' U B 68 0.440 -7.434 -4.306 1.00 1.00 H +ATOM 2195 H3' U B 68 2.426 -6.176 -6.203 1.00 1.00 H +ATOM 2196 H2' U B 68 3.749 -5.461 -4.448 1.00 1.00 H +ATOM 2197 HO2' U B 68 1.612 -5.754 -2.595 1.00 1.00 H +ATOM 2198 H1' U B 68 3.007 -7.431 -2.536 1.00 1.00 H +ATOM 2199 H3 U B 68 7.500 -7.941 -2.517 1.00 1.00 H +ATOM 2200 H5 U B 68 6.381 -9.083 -6.417 1.00 1.00 H +ATOM 2201 H6 U B 68 4.114 -8.387 -5.899 1.00 1.00 H +ATOM 2202 P U B 69 1.146 -3.699 -5.772 1.00 1.00 P +ATOM 2203 OP1 U B 69 -0.152 -3.034 -6.023 1.00 1.00 O +ATOM 2204 OP2 U B 69 2.152 -3.786 -6.853 1.00 1.00 O +ATOM 2205 O5' U B 69 1.833 -2.992 -4.499 1.00 1.00 O +ATOM 2206 C5' U B 69 1.103 -2.802 -3.284 1.00 1.00 C +ATOM 2207 C4' U B 69 2.005 -2.287 -2.168 1.00 1.00 C +ATOM 2208 O4' U B 69 2.958 -3.280 -1.819 1.00 1.00 O +ATOM 2209 C3' U B 69 2.799 -1.048 -2.529 1.00 1.00 C +ATOM 2210 O3' U B 69 2.041 0.130 -2.222 1.00 1.00 O +ATOM 2211 C2' U B 69 4.022 -1.152 -1.629 1.00 1.00 C +ATOM 2212 O2' U B 69 3.835 -0.463 -0.390 1.00 1.00 O +ATOM 2213 C1' U B 69 4.187 -2.654 -1.415 1.00 1.00 C +ATOM 2214 N1 U B 69 5.259 -3.232 -2.246 1.00 1.00 N +ATOM 2215 C2 U B 69 6.486 -3.496 -1.665 1.00 1.00 C +ATOM 2216 O2 U B 69 6.713 -3.258 -0.480 1.00 1.00 O +ATOM 2217 N3 U B 69 7.447 -4.041 -2.497 1.00 1.00 N +ATOM 2218 C4 U B 69 7.290 -4.342 -3.839 1.00 1.00 C +ATOM 2219 O4 U B 69 8.216 -4.827 -4.486 1.00 1.00 O +ATOM 2220 C5 U B 69 5.977 -4.033 -4.362 1.00 1.00 C +ATOM 2221 C6 U B 69 5.020 -3.500 -3.565 1.00 1.00 C +ATOM 2222 H5' U B 69 0.667 -3.754 -2.977 1.00 1.00 H +ATOM 2223 H5'' U B 69 0.301 -2.084 -3.454 1.00 1.00 H +ATOM 2224 H4' U B 69 1.396 -2.076 -1.292 1.00 1.00 H +ATOM 2225 H3' U B 69 3.091 -1.070 -3.582 1.00 1.00 H +ATOM 2226 H2' U B 69 4.890 -0.776 -2.155 1.00 1.00 H +ATOM 2227 HO2' U B 69 4.695 -0.397 0.030 1.00 1.00 H +ATOM 2228 H1' U B 69 4.378 -2.861 -0.363 1.00 1.00 H +ATOM 2229 H3 U B 69 8.349 -4.239 -2.087 1.00 1.00 H +ATOM 2230 H5 U B 69 5.755 -4.232 -5.410 1.00 1.00 H +ATOM 2231 H6 U B 69 4.037 -3.280 -3.984 1.00 1.00 H +ATOM 2232 P G B 70 2.358 1.528 -2.963 1.00 1.00 P +ATOM 2233 OP1 G B 70 1.363 2.527 -2.515 1.00 1.00 O +ATOM 2234 OP2 G B 70 2.535 1.259 -4.408 1.00 1.00 O +ATOM 2235 O5' G B 70 3.790 1.929 -2.346 1.00 1.00 O +ATOM 2236 C5' G B 70 3.962 2.018 -0.931 1.00 1.00 C +ATOM 2237 C4' G B 70 5.430 1.908 -0.526 1.00 1.00 C +ATOM 2238 O4' G B 70 6.026 0.764 -1.142 1.00 1.00 O +ATOM 2239 C3' G B 70 6.293 3.094 -0.930 1.00 1.00 C +ATOM 2240 O3' G B 70 6.303 4.055 0.134 1.00 1.00 O +ATOM 2241 C2' G B 70 7.683 2.494 -1.071 1.00 1.00 C +ATOM 2242 O2' G B 70 8.478 2.738 0.092 1.00 1.00 O +ATOM 2243 C1' G B 70 7.434 1.003 -1.278 1.00 1.00 C +ATOM 2244 N9 G B 70 7.917 0.490 -2.576 1.00 1.00 N +ATOM 2245 C8 G B 70 7.214 0.044 -3.666 1.00 1.00 C +ATOM 2246 N7 G B 70 7.966 -0.408 -4.631 1.00 1.00 N +ATOM 2247 C5 G B 70 9.262 -0.246 -4.148 1.00 1.00 C +ATOM 2248 C6 G B 70 10.508 -0.562 -4.757 1.00 1.00 C +ATOM 2249 O6 G B 70 10.714 -1.060 -5.862 1.00 1.00 O +ATOM 2250 N1 G B 70 11.575 -0.237 -3.930 1.00 1.00 N +ATOM 2251 C2 G B 70 11.461 0.320 -2.674 1.00 1.00 C +ATOM 2252 N2 G B 70 12.599 0.569 -2.029 1.00 1.00 N +ATOM 2253 N3 G B 70 10.292 0.613 -2.100 1.00 1.00 N +ATOM 2254 C4 G B 70 9.241 0.305 -2.893 1.00 1.00 C +ATOM 2255 H5' G B 70 3.399 1.215 -0.453 1.00 1.00 H +ATOM 2256 H5'' G B 70 3.573 2.976 -0.586 1.00 1.00 H +ATOM 2257 H4' G B 70 5.485 1.785 0.555 1.00 1.00 H +ATOM 2258 H3' G B 70 5.950 3.531 -1.869 1.00 1.00 H +ATOM 2259 H2' G B 70 8.167 2.911 -1.962 1.00 1.00 H +ATOM 2260 HO2' G B 70 7.929 3.222 0.716 1.00 1.00 H +ATOM 2261 H1' G B 70 7.945 0.458 -0.488 1.00 1.00 H +ATOM 2262 H8 G B 70 6.126 0.069 -3.724 1.00 1.00 H +ATOM 2263 H1 G B 70 12.496 -0.435 -4.294 1.00 1.00 H +ATOM 2264 H21 G B 70 13.486 0.346 -2.463 1.00 1.00 H +ATOM 2265 H22 G B 70 12.577 0.975 -1.106 1.00 1.00 H +ATOM 2266 P G B 71 6.984 5.501 -0.063 1.00 1.00 P +ATOM 2267 OP1 G B 71 6.325 6.452 0.860 1.00 1.00 O +ATOM 2268 OP2 G B 71 7.036 5.795 -1.512 1.00 1.00 O +ATOM 2269 O5' G B 71 8.495 5.268 0.457 1.00 1.00 O +ATOM 2270 C5' G B 71 8.798 5.239 1.860 1.00 1.00 C +ATOM 2271 C4' G B 71 10.306 5.218 2.105 1.00 1.00 C +ATOM 2272 O4' G B 71 10.861 3.983 1.650 1.00 1.00 O +ATOM 2273 C3' G B 71 11.058 6.334 1.393 1.00 1.00 C +ATOM 2274 O3' G B 71 11.216 7.453 2.271 1.00 1.00 O +ATOM 2275 C2' G B 71 12.407 5.713 1.081 1.00 1.00 C +ATOM 2276 O2' G B 71 13.353 5.945 2.128 1.00 1.00 O +ATOM 2277 C1' G B 71 12.080 4.236 0.935 1.00 1.00 C +ATOM 2278 N9 G B 71 11.862 3.825 -0.456 1.00 1.00 N +ATOM 2279 C8 G B 71 10.674 3.708 -1.130 1.00 1.00 C +ATOM 2280 N7 G B 71 10.801 3.313 -2.365 1.00 1.00 N +ATOM 2281 C5 G B 71 12.173 3.154 -2.526 1.00 1.00 C +ATOM 2282 C6 G B 71 12.912 2.740 -3.669 1.00 1.00 C +ATOM 2283 O6 G B 71 12.488 2.430 -4.779 1.00 1.00 O +ATOM 2284 N1 G B 71 14.275 2.712 -3.410 1.00 1.00 N +ATOM 2285 C2 G B 71 14.859 3.040 -2.205 1.00 1.00 C +ATOM 2286 N2 G B 71 16.188 2.950 -2.153 1.00 1.00 N +ATOM 2287 N3 G B 71 14.167 3.430 -1.129 1.00 1.00 N +ATOM 2288 C4 G B 71 12.833 3.464 -1.362 1.00 1.00 C +ATOM 2289 H5' G B 71 8.352 4.349 2.304 1.00 1.00 H +ATOM 2290 H5'' G B 71 8.374 6.124 2.334 1.00 1.00 H +ATOM 2291 H4' G B 71 10.486 5.299 3.175 1.00 1.00 H +ATOM 2292 H3' G B 71 10.542 6.619 0.474 1.00 1.00 H +ATOM 2293 H2' G B 71 12.777 6.097 0.131 1.00 1.00 H +ATOM 2294 HO2' G B 71 14.128 6.344 1.726 1.00 1.00 H +ATOM 2295 H1' G B 71 12.882 3.639 1.364 1.00 1.00 H +ATOM 2296 H8 G B 71 9.708 3.922 -0.673 1.00 1.00 H +ATOM 2297 H1 G B 71 14.866 2.426 -4.177 1.00 1.00 H +ATOM 2298 H21 G B 71 16.707 2.656 -2.967 1.00 1.00 H +ATOM 2299 H22 G B 71 16.675 3.178 -1.298 1.00 1.00 H +ATOM 2300 P U B 72 11.430 8.935 1.677 1.00 1.00 P +ATOM 2301 OP1 U B 72 11.366 9.897 2.800 1.00 1.00 O +ATOM 2302 OP2 U B 72 10.530 9.101 0.514 1.00 1.00 O +ATOM 2303 O5' U B 72 12.947 8.894 1.138 1.00 1.00 O +ATOM 2304 C5' U B 72 14.047 9.063 2.039 1.00 1.00 C +ATOM 2305 C4' U B 72 15.385 8.994 1.309 1.00 1.00 C +ATOM 2306 O4' U B 72 15.490 7.761 0.608 1.00 1.00 O +ATOM 2307 C3' U B 72 15.591 10.090 0.276 1.00 1.00 C +ATOM 2308 O3' U B 72 16.191 11.237 0.889 1.00 1.00 O +ATOM 2309 C2' U B 72 16.552 9.451 -0.711 1.00 1.00 C +ATOM 2310 O2' U B 72 17.918 9.707 -0.367 1.00 1.00 O +ATOM 2311 C1' U B 72 16.220 7.964 -0.610 1.00 1.00 C +ATOM 2312 N1 U B 72 15.369 7.476 -1.710 1.00 1.00 N +ATOM 2313 C2 U B 72 15.990 6.937 -2.820 1.00 1.00 C +ATOM 2314 O2 U B 72 17.214 6.858 -2.911 1.00 1.00 O +ATOM 2315 N3 U B 72 15.154 6.489 -3.827 1.00 1.00 N +ATOM 2316 C4 U B 72 13.770 6.534 -3.819 1.00 1.00 C +ATOM 2317 O4 U B 72 13.124 6.106 -4.773 1.00 1.00 O +ATOM 2318 C5 U B 72 13.207 7.113 -2.620 1.00 1.00 C +ATOM 2319 C6 U B 72 14.006 7.558 -1.620 1.00 1.00 C +ATOM 2320 H5' U B 72 14.014 8.279 2.797 1.00 1.00 H +ATOM 2321 H5'' U B 72 13.959 10.033 2.526 1.00 1.00 H +ATOM 2322 H4' U B 72 16.190 9.039 2.040 1.00 1.00 H +ATOM 2323 H3' U B 72 14.647 10.344 -0.210 1.00 1.00 H +ATOM 2324 H2' U B 72 16.336 9.804 -1.715 1.00 1.00 H +ATOM 2325 HO2' U B 72 18.453 9.453 -1.125 1.00 1.00 H +ATOM 2326 H1' U B 72 17.143 7.385 -0.579 1.00 1.00 H +ATOM 2327 H3 U B 72 15.594 6.092 -4.644 1.00 1.00 H +ATOM 2328 H5 U B 72 12.125 7.193 -2.519 1.00 1.00 H +ATOM 2329 H6 U B 72 13.555 7.991 -0.728 1.00 1.00 H +ATOM 2330 P U B 73 15.893 12.719 0.327 1.00 1.00 P +ATOM 2331 OP1 U B 73 16.523 13.696 1.243 1.00 1.00 O +ATOM 2332 OP2 U B 73 14.445 12.816 0.032 1.00 1.00 O +ATOM 2333 O5' U B 73 16.694 12.753 -1.072 1.00 1.00 O +ATOM 2334 C5' U B 73 18.101 13.020 -1.107 1.00 1.00 C +ATOM 2335 C4' U B 73 18.644 12.980 -2.533 1.00 1.00 C +ATOM 2336 O4' U B 73 18.455 11.681 -3.083 1.00 1.00 O +ATOM 2337 C3' U B 73 17.970 13.950 -3.490 1.00 1.00 C +ATOM 2338 O3' U B 73 18.641 15.215 -3.474 1.00 1.00 O +ATOM 2339 C2' U B 73 18.155 13.276 -4.838 1.00 1.00 C +ATOM 2340 O2' U B 73 19.386 13.655 -5.460 1.00 1.00 O +ATOM 2341 C1' U B 73 18.136 11.792 -4.479 1.00 1.00 C +ATOM 2342 N1 U B 73 16.820 11.160 -4.674 1.00 1.00 N +ATOM 2343 C2 U B 73 16.594 10.466 -5.848 1.00 1.00 C +ATOM 2344 O2 U B 73 17.444 10.382 -6.732 1.00 1.00 O +ATOM 2345 N3 U B 73 15.351 9.873 -5.972 1.00 1.00 N +ATOM 2346 C4 U B 73 14.329 9.913 -5.039 1.00 1.00 C +ATOM 2347 O4 U B 73 13.260 9.343 -5.254 1.00 1.00 O +ATOM 2348 C5 U B 73 14.652 10.660 -3.845 1.00 1.00 C +ATOM 2349 C6 U B 73 15.864 11.250 -3.699 1.00 1.00 C +ATOM 2350 H5' U B 73 18.622 12.273 -0.507 1.00 1.00 H +ATOM 2351 H5'' U B 73 18.287 14.007 -0.684 1.00 1.00 H +ATOM 2352 H4' U B 73 19.711 13.186 -2.508 1.00 1.00 H +ATOM 2353 H3' U B 73 16.909 14.056 -3.253 1.00 1.00 H +ATOM 2354 H2' U B 73 17.312 13.506 -5.481 1.00 1.00 H +ATOM 2355 HO2' U B 73 19.235 13.656 -6.408 1.00 1.00 H +ATOM 2356 H1' U B 73 18.885 11.257 -5.062 1.00 1.00 H +ATOM 2357 H3 U B 73 15.171 9.362 -6.825 1.00 1.00 H +ATOM 2358 H5 U B 73 13.912 10.750 -3.051 1.00 1.00 H +ATOM 2359 H6 U B 73 16.079 11.809 -2.789 1.00 1.00 H +ATOM 2360 P C B 74 17.831 16.575 -3.786 1.00 1.00 P +ATOM 2361 OP1 C B 74 18.783 17.705 -3.718 1.00 1.00 O +ATOM 2362 OP2 C B 74 16.611 16.589 -2.948 1.00 1.00 O +ATOM 2363 O5' C B 74 17.382 16.388 -5.325 1.00 1.00 O +ATOM 2364 C5' C B 74 18.302 16.641 -6.392 1.00 1.00 C +ATOM 2365 C4' C B 74 17.829 16.021 -7.704 1.00 1.00 C +ATOM 2366 O4' C B 74 17.500 14.655 -7.504 1.00 1.00 O +ATOM 2367 C3' C B 74 16.582 16.657 -8.292 1.00 1.00 C +ATOM 2368 O3' C B 74 16.945 17.780 -9.093 1.00 1.00 O +ATOM 2369 C2' C B 74 16.033 15.545 -9.173 1.00 1.00 C +ATOM 2370 O2' C B 74 16.563 15.611 -10.502 1.00 1.00 O +ATOM 2371 C1' C B 74 16.490 14.278 -8.450 1.00 1.00 C +ATOM 2372 N1 C B 74 15.410 13.616 -7.704 1.00 1.00 N +ATOM 2373 C2 C B 74 14.773 12.547 -8.314 1.00 1.00 C +ATOM 2374 O2 C B 74 15.111 12.194 -9.443 1.00 1.00 O +ATOM 2375 N3 C B 74 13.777 11.914 -7.636 1.00 1.00 N +ATOM 2376 C4 C B 74 13.419 12.314 -6.408 1.00 1.00 C +ATOM 2377 N4 C B 74 12.439 11.672 -5.770 1.00 1.00 N +ATOM 2378 C5 C B 74 14.072 13.418 -5.774 1.00 1.00 C +ATOM 2379 C6 C B 74 15.057 14.037 -6.454 1.00 1.00 C +ATOM 2380 H5' C B 74 19.276 16.222 -6.132 1.00 1.00 H +ATOM 2381 H5'' C B 74 18.404 17.716 -6.527 1.00 1.00 H +ATOM 2382 H4' C B 74 18.635 16.076 -8.431 1.00 1.00 H +ATOM 2383 H3' C B 74 15.871 16.928 -7.508 1.00 1.00 H +ATOM 2384 H2' C B 74 14.945 15.587 -9.188 1.00 1.00 H +ATOM 2385 HO2' C B 74 17.400 16.077 -10.452 1.00 1.00 H +ATOM 2386 H1' C B 74 16.916 13.579 -9.169 1.00 1.00 H +ATOM 2387 H41 C B 74 11.975 10.890 -6.223 1.00 1.00 H +ATOM 2388 H42 C B 74 12.159 11.964 -4.845 1.00 1.00 H +ATOM 2389 H5 C B 74 13.785 13.746 -4.773 1.00 1.00 H +ATOM 2390 H6 C B 74 15.577 14.882 -6.001 1.00 1.00 H +ATOM 2391 P U B 75 16.211 19.197 -8.898 1.00 1.00 P +ATOM 2392 OP1 U B 75 17.087 20.250 -9.458 1.00 1.00 O +ATOM 2393 OP2 U B 75 15.758 19.293 -7.492 1.00 1.00 O +ATOM 2394 O5' U B 75 14.906 19.084 -9.839 1.00 1.00 O +ATOM 2395 C5' U B 75 15.000 18.455 -11.121 1.00 1.00 C +ATOM 2396 C4' U B 75 13.821 17.513 -11.393 1.00 1.00 C +ATOM 2397 O4' U B 75 13.820 16.411 -10.488 1.00 1.00 O +ATOM 2398 C3' U B 75 12.453 18.154 -11.253 1.00 1.00 C +ATOM 2399 O3' U B 75 12.067 18.733 -12.498 1.00 1.00 O +ATOM 2400 C2' U B 75 11.537 16.982 -10.947 1.00 1.00 C +ATOM 2401 O2' U B 75 10.852 16.532 -12.119 1.00 1.00 O +ATOM 2402 C1' U B 75 12.476 15.911 -10.395 1.00 1.00 C +ATOM 2403 N1 U B 75 12.180 15.518 -8.998 1.00 1.00 N +ATOM 2404 C2 U B 75 11.273 14.492 -8.818 1.00 1.00 C +ATOM 2405 O2 U B 75 10.724 13.931 -9.765 1.00 1.00 O +ATOM 2406 N3 U B 75 11.014 14.132 -7.508 1.00 1.00 N +ATOM 2407 C4 U B 75 11.577 14.700 -6.377 1.00 1.00 C +ATOM 2408 O4 U B 75 11.275 14.298 -5.257 1.00 1.00 O +ATOM 2409 C5 U B 75 12.514 15.766 -6.660 1.00 1.00 C +ATOM 2410 C6 U B 75 12.783 16.136 -7.936 1.00 1.00 C +ATOM 2411 H5' U B 75 15.930 17.885 -11.171 1.00 1.00 H +ATOM 2412 H5'' U B 75 15.016 19.226 -11.891 1.00 1.00 H +ATOM 2413 H4' U B 75 13.920 17.122 -12.404 1.00 1.00 H +ATOM 2414 H3' U B 75 12.442 18.886 -10.444 1.00 1.00 H +ATOM 2415 H2' U B 75 10.827 17.271 -10.171 1.00 1.00 H +ATOM 2416 HO2' U B 75 11.234 15.686 -12.364 1.00 1.00 H +ATOM 2417 H1' U B 75 12.397 15.028 -11.029 1.00 1.00 H +ATOM 2418 H3 U B 75 10.353 13.382 -7.361 1.00 1.00 H +ATOM 2419 H5 U B 75 13.011 16.277 -5.836 1.00 1.00 H +ATOM 2420 H6 U B 75 13.493 16.943 -8.119 1.00 1.00 H +ATOM 2421 P U B 76 10.788 19.707 -12.594 1.00 1.00 P +ATOM 2422 OP1 U B 76 10.773 20.317 -13.941 1.00 1.00 O +ATOM 2423 OP2 U B 76 10.772 20.571 -11.393 1.00 1.00 O +ATOM 2424 O5' U B 76 9.548 18.682 -12.495 1.00 1.00 O +ATOM 2425 C5' U B 76 9.173 17.881 -13.621 1.00 1.00 C +ATOM 2426 C4' U B 76 7.923 17.052 -13.337 1.00 1.00 C +ATOM 2427 O4' U B 76 8.176 16.147 -12.271 1.00 1.00 O +ATOM 2428 C3' U B 76 6.710 17.866 -12.924 1.00 1.00 C +ATOM 2429 O3' U B 76 5.939 18.196 -14.082 1.00 1.00 O +ATOM 2430 C2' U B 76 5.918 16.916 -12.036 1.00 1.00 C +ATOM 2431 O2' U B 76 4.873 16.267 -12.767 1.00 1.00 O +ATOM 2432 C1' U B 76 6.961 15.911 -11.547 1.00 1.00 C +ATOM 2433 N1 U B 76 7.266 16.031 -10.109 1.00 1.00 N +ATOM 2434 C2 U B 76 6.606 15.185 -9.237 1.00 1.00 C +ATOM 2435 O2 U B 76 5.793 14.349 -9.627 1.00 1.00 O +ATOM 2436 N3 U B 76 6.916 15.331 -7.898 1.00 1.00 N +ATOM 2437 C4 U B 76 7.815 16.238 -7.361 1.00 1.00 C +ATOM 2438 O4 U B 76 8.013 16.281 -6.148 1.00 1.00 O +ATOM 2439 C5 U B 76 8.457 17.081 -8.344 1.00 1.00 C +ATOM 2440 C6 U B 76 8.171 16.956 -9.662 1.00 1.00 C +ATOM 2441 H5' U B 76 9.995 17.210 -13.872 1.00 1.00 H +ATOM 2442 H5'' U B 76 8.977 18.535 -14.471 1.00 1.00 H +ATOM 2443 H4' U B 76 7.674 16.474 -14.225 1.00 1.00 H +ATOM 2444 H3' U B 76 7.007 18.761 -12.374 1.00 1.00 H +ATOM 2445 H2' U B 76 5.508 17.465 -11.185 1.00 1.00 H +ATOM 2446 HO2' U B 76 4.558 15.538 -12.227 1.00 1.00 H +ATOM 2447 H1' U B 76 6.611 14.901 -11.760 1.00 1.00 H +ATOM 2448 H3 U B 76 6.442 14.719 -7.249 1.00 1.00 H +ATOM 2449 H5 U B 76 9.182 17.828 -8.021 1.00 1.00 H +ATOM 2450 H6 U B 76 8.670 17.605 -10.382 1.00 1.00 H +ATOM 2451 P C B 77 4.774 19.301 -13.997 1.00 1.00 P +ATOM 2452 OP1 C B 77 4.229 19.503 -15.358 1.00 1.00 O +ATOM 2453 OP2 C B 77 5.284 20.456 -13.226 1.00 1.00 O +ATOM 2454 O5' C B 77 3.652 18.558 -13.111 1.00 1.00 O +ATOM 2455 C5' C B 77 2.972 19.256 -12.064 1.00 1.00 C +ATOM 2456 C4' C B 77 1.972 18.354 -11.343 1.00 1.00 C +ATOM 2457 O4' C B 77 2.670 17.360 -10.599 1.00 1.00 O +ATOM 2458 C3' C B 77 1.075 19.090 -10.362 1.00 1.00 C +ATOM 2459 O3' C B 77 -0.150 19.453 -11.008 1.00 1.00 O +ATOM 2460 C2' C B 77 0.795 18.065 -9.273 1.00 1.00 C +ATOM 2461 O2' C B 77 -0.452 17.398 -9.497 1.00 1.00 O +ATOM 2462 C1' C B 77 1.971 17.094 -9.375 1.00 1.00 C +ATOM 2463 N1 C B 77 2.946 17.222 -8.278 1.00 1.00 N +ATOM 2464 C2 C B 77 2.632 16.623 -7.068 1.00 1.00 C +ATOM 2465 O2 C B 77 1.569 16.017 -6.939 1.00 1.00 O +ATOM 2466 N3 C B 77 3.525 16.724 -6.046 1.00 1.00 N +ATOM 2467 C4 C B 77 4.678 17.387 -6.204 1.00 1.00 C +ATOM 2468 N4 C B 77 5.532 17.465 -5.183 1.00 1.00 N +ATOM 2469 C5 C B 77 5.005 18.009 -7.450 1.00 1.00 C +ATOM 2470 C6 C B 77 4.115 17.903 -8.455 1.00 1.00 C +ATOM 2471 H5' C B 77 2.439 20.106 -12.492 1.00 1.00 H +ATOM 2472 H5'' C B 77 3.705 19.620 -11.345 1.00 1.00 H +ATOM 2473 H4' C B 77 1.351 17.856 -12.084 1.00 1.00 H +ATOM 2474 H3' C B 77 1.581 19.965 -9.950 1.00 1.00 H +ATOM 2475 H2' C B 77 0.801 18.553 -8.296 1.00 1.00 H +ATOM 2476 HO2' C B 77 -0.969 17.951 -10.087 1.00 1.00 H +ATOM 2477 H1' C B 77 1.591 16.074 -9.394 1.00 1.00 H +ATOM 2478 H41 C B 77 5.305 17.027 -4.301 1.00 1.00 H +ATOM 2479 H42 C B 77 6.403 17.963 -5.289 1.00 1.00 H +ATOM 2480 H5 C B 77 5.943 18.552 -7.580 1.00 1.00 H +ATOM 2481 H6 C B 77 4.331 18.364 -9.418 1.00 1.00 H +ATOM 2482 P C B 78 -1.057 20.647 -10.423 1.00 1.00 P +ATOM 2483 OP1 C B 78 -2.347 20.647 -11.149 1.00 1.00 O +ATOM 2484 OP2 C B 78 -0.236 21.877 -10.377 1.00 1.00 O +ATOM 2485 O5' C B 78 -1.333 20.166 -8.911 1.00 1.00 O +ATOM 2486 C5' C B 78 -1.388 21.118 -7.844 1.00 1.00 C +ATOM 2487 C4' C B 78 -2.185 20.584 -6.657 1.00 1.00 C +ATOM 2488 O4' C B 78 -1.522 19.445 -6.106 1.00 1.00 O +ATOM 2489 C3' C B 78 -2.360 21.592 -5.532 1.00 1.00 C +ATOM 2490 O3' C B 78 -3.623 22.249 -5.668 1.00 1.00 O +ATOM 2491 C2' C B 78 -2.357 20.742 -4.270 1.00 1.00 C +ATOM 2492 O2' C B 78 -3.691 20.414 -3.863 1.00 1.00 O +ATOM 2493 C1' C B 78 -1.577 19.494 -4.673 1.00 1.00 C +ATOM 2494 N1 C B 78 -0.189 19.470 -4.170 1.00 1.00 N +ATOM 2495 C2 C B 78 -0.007 19.308 -2.806 1.00 1.00 C +ATOM 2496 O2 C B 78 -0.982 19.195 -2.065 1.00 1.00 O +ATOM 2497 N3 C B 78 1.265 19.280 -2.322 1.00 1.00 N +ATOM 2498 C4 C B 78 2.316 19.408 -3.145 1.00 1.00 C +ATOM 2499 N4 C B 78 3.549 19.377 -2.639 1.00 1.00 N +ATOM 2500 C5 C B 78 2.133 19.574 -4.554 1.00 1.00 C +ATOM 2501 C6 C B 78 0.870 19.600 -5.021 1.00 1.00 C +ATOM 2502 H5' C B 78 -1.859 22.030 -8.207 1.00 1.00 H +ATOM 2503 H5'' C B 78 -0.373 21.345 -7.518 1.00 1.00 H +ATOM 2504 H4' C B 78 -3.168 20.274 -7.007 1.00 1.00 H +ATOM 2505 H3' C B 78 -1.538 22.308 -5.519 1.00 1.00 H +ATOM 2506 H2' C B 78 -1.829 21.268 -3.470 1.00 1.00 H +ATOM 2507 HO2' C B 78 -3.721 19.464 -3.726 1.00 1.00 H +ATOM 2508 H1' C B 78 -2.101 18.613 -4.305 1.00 1.00 H +ATOM 2509 H41 C B 78 3.684 19.260 -1.650 1.00 1.00 H +ATOM 2510 H42 C B 78 4.347 19.471 -3.252 1.00 1.00 H +ATOM 2511 H5 C B 78 2.985 19.679 -5.225 1.00 1.00 H +ATOM 2512 H6 C B 78 0.693 19.727 -6.089 1.00 1.00 H +ATOM 2513 P U B 79 -3.945 23.581 -4.824 1.00 1.00 P +ATOM 2514 OP1 U B 79 -5.222 24.147 -5.317 1.00 1.00 O +ATOM 2515 OP2 U B 79 -2.727 24.421 -4.801 1.00 1.00 O +ATOM 2516 O5' U B 79 -4.187 23.004 -3.342 1.00 1.00 O +ATOM 2517 C5' U B 79 -3.960 23.829 -2.197 1.00 1.00 C +ATOM 2518 C4' U B 79 -4.075 23.033 -0.901 1.00 1.00 C +ATOM 2519 O4' U B 79 -3.044 22.047 -0.850 1.00 1.00 O +ATOM 2520 C3' U B 79 -3.949 23.882 0.353 1.00 1.00 C +ATOM 2521 O3' U B 79 -5.256 24.242 0.814 1.00 1.00 O +ATOM 2522 C2' U B 79 -3.271 22.961 1.359 1.00 1.00 C +ATOM 2523 O2' U B 79 -4.228 22.327 2.215 1.00 1.00 O +ATOM 2524 C1' U B 79 -2.543 21.936 0.490 1.00 1.00 C +ATOM 2525 N1 U B 79 -1.081 22.134 0.436 1.00 1.00 N +ATOM 2526 C2 U B 79 -0.375 21.970 1.611 1.00 1.00 C +ATOM 2527 O2 U B 79 -0.927 21.678 2.670 1.00 1.00 O +ATOM 2528 N3 U B 79 0.993 22.155 1.529 1.00 1.00 N +ATOM 2529 C4 U B 79 1.705 22.485 0.388 1.00 1.00 C +ATOM 2530 O4 U B 79 2.926 22.624 0.430 1.00 1.00 O +ATOM 2531 C5 U B 79 0.886 22.638 -0.794 1.00 1.00 C +ATOM 2532 C6 U B 79 -0.455 22.461 -0.737 1.00 1.00 C +ATOM 2533 H5' U B 79 -4.694 24.634 -2.186 1.00 1.00 H +ATOM 2534 H5'' U B 79 -2.961 24.260 -2.262 1.00 1.00 H +ATOM 2535 H4' U B 79 -5.038 22.524 -0.887 1.00 1.00 H +ATOM 2536 H3' U B 79 -3.338 24.767 0.163 1.00 1.00 H +ATOM 2537 H2' U B 79 -2.546 23.527 1.948 1.00 1.00 H +ATOM 2538 HO2' U B 79 -3.742 21.931 2.943 1.00 1.00 H +ATOM 2539 H1' U B 79 -2.751 20.934 0.866 1.00 1.00 H +ATOM 2540 H3 U B 79 1.522 22.037 2.381 1.00 1.00 H +ATOM 2541 H5 U B 79 1.355 22.897 -1.742 1.00 1.00 H +ATOM 2542 H6 U B 79 -1.049 22.583 -1.644 1.00 1.00 H +ATOM 2543 P A B 80 -5.519 25.663 1.523 1.00 1.00 P +ATOM 2544 OP1 A B 80 -6.980 25.837 1.686 1.00 1.00 O +ATOM 2545 OP2 A B 80 -4.731 26.690 0.807 1.00 1.00 O +ATOM 2546 O5' A B 80 -4.871 25.455 2.981 1.00 1.00 O +ATOM 2547 C5' A B 80 -5.395 24.469 3.874 1.00 1.00 C +ATOM 2548 C4' A B 80 -4.472 24.247 5.067 1.00 1.00 C +ATOM 2549 O4' A B 80 -3.159 23.935 4.596 1.00 1.00 O +ATOM 2550 C3' A B 80 -4.354 25.456 5.988 1.00 1.00 C +ATOM 2551 O3' A B 80 -4.270 25.008 7.345 1.00 1.00 O +ATOM 2552 C2' A B 80 -3.044 26.112 5.584 1.00 1.00 C +ATOM 2553 O2' A B 80 -2.373 26.677 6.714 1.00 1.00 O +ATOM 2554 C1' A B 80 -2.242 24.966 4.979 1.00 1.00 C +ATOM 2555 N9 A B 80 -1.474 25.345 3.779 1.00 1.00 N +ATOM 2556 C8 A B 80 -1.897 26.025 2.666 1.00 1.00 C +ATOM 2557 N7 A B 80 -0.964 26.203 1.771 1.00 1.00 N +ATOM 2558 C5 A B 80 0.156 25.597 2.332 1.00 1.00 C +ATOM 2559 C6 A B 80 1.476 25.441 1.879 1.00 1.00 C +ATOM 2560 N6 A B 80 1.905 25.903 0.703 1.00 1.00 N +ATOM 2561 N1 A B 80 2.331 24.790 2.685 1.00 1.00 N +ATOM 2562 C2 A B 80 1.898 24.330 3.854 1.00 1.00 C +ATOM 2563 N3 A B 80 0.689 24.414 4.388 1.00 1.00 N +ATOM 2564 C4 A B 80 -0.146 25.071 3.555 1.00 1.00 C +ATOM 2565 H5' A B 80 -5.515 23.528 3.336 1.00 1.00 H +ATOM 2566 H5'' A B 80 -6.369 24.798 4.234 1.00 1.00 H +ATOM 2567 H4' A B 80 -4.840 23.401 5.644 1.00 1.00 H +ATOM 2568 H3' A B 80 -5.194 26.138 5.847 1.00 1.00 H +ATOM 2569 H2' A B 80 -3.231 26.876 4.825 1.00 1.00 H +ATOM 2570 HO2' A B 80 -1.433 26.524 6.595 1.00 1.00 H +ATOM 2571 H1' A B 80 -1.556 24.575 5.729 1.00 1.00 H +ATOM 2572 H8 A B 80 -2.918 26.385 2.541 1.00 1.00 H +ATOM 2573 H61 A B 80 2.866 25.764 0.425 1.00 1.00 H +ATOM 2574 H62 A B 80 1.268 26.394 0.091 1.00 1.00 H +ATOM 2575 H2 A B 80 2.644 23.812 4.458 1.00 1.00 H +ATOM 2576 P A B 81 -4.732 25.966 8.553 1.00 1.00 P +ATOM 2577 OP1 A B 81 -6.209 26.044 8.541 1.00 1.00 O +ATOM 2578 OP2 A B 81 -3.926 27.207 8.496 1.00 1.00 O +ATOM 2579 O5' A B 81 -4.281 25.130 9.854 1.00 1.00 O +ATOM 2580 C5' A B 81 -5.145 24.144 10.423 1.00 1.00 C +ATOM 2581 C4' A B 81 -4.372 23.143 11.274 1.00 1.00 C +ATOM 2582 O4' A B 81 -3.855 22.105 10.436 1.00 1.00 O +ATOM 2583 C3' A B 81 -3.196 23.759 12.025 1.00 1.00 C +ATOM 2584 O3' A B 81 -3.567 24.001 13.386 1.00 1.00 O +ATOM 2585 C2' A B 81 -2.120 22.686 11.977 1.00 1.00 C +ATOM 2586 O2' A B 81 -2.149 21.867 13.151 1.00 1.00 O +ATOM 2587 C1' A B 81 -2.472 21.882 10.731 1.00 1.00 C +ATOM 2588 N9 A B 81 -1.697 22.263 9.537 1.00 1.00 N +ATOM 2589 C8 A B 81 -2.081 23.041 8.477 1.00 1.00 C +ATOM 2590 N7 A B 81 -1.153 23.194 7.571 1.00 1.00 N +ATOM 2591 C5 A B 81 -0.079 22.463 8.068 1.00 1.00 C +ATOM 2592 C6 A B 81 1.214 22.222 7.576 1.00 1.00 C +ATOM 2593 N6 A B 81 1.659 22.718 6.421 1.00 1.00 N +ATOM 2594 N1 A B 81 2.024 21.452 8.322 1.00 1.00 N +ATOM 2595 C2 A B 81 1.575 20.962 9.471 1.00 1.00 C +ATOM 2596 N3 A B 81 0.388 21.115 10.038 1.00 1.00 N +ATOM 2597 C4 A B 81 -0.402 21.891 9.266 1.00 1.00 C +ATOM 2598 H5' A B 81 -5.652 23.610 9.619 1.00 1.00 H +ATOM 2599 H5'' A B 81 -5.892 24.639 11.044 1.00 1.00 H +ATOM 2600 H4' A B 81 -5.052 22.694 11.994 1.00 1.00 H +ATOM 2601 H3' A B 81 -2.856 24.673 11.535 1.00 1.00 H +ATOM 2602 H2' A B 81 -1.140 23.148 11.854 1.00 1.00 H +ATOM 2603 HO2' A B 81 -3.063 21.807 13.437 1.00 1.00 H +ATOM 2604 H1' A B 81 -2.314 20.822 10.932 1.00 1.00 H +ATOM 2605 H8 A B 81 -3.070 23.492 8.396 1.00 1.00 H +ATOM 2606 H61 A B 81 2.600 22.514 6.112 1.00 1.00 H +ATOM 2607 H62 A B 81 1.056 23.297 5.855 1.00 1.00 H +ATOM 2608 H2 A B 81 2.283 20.345 10.024 1.00 1.00 H +ATOM 2609 P G B 82 -2.571 24.795 14.374 1.00 1.00 P +ATOM 2610 OP1 G B 82 -3.388 25.519 15.372 1.00 1.00 O +ATOM 2611 OP2 G B 82 -1.591 25.534 13.548 1.00 1.00 O +ATOM 2612 O5' G B 82 -1.796 23.600 15.127 1.00 1.00 O +ATOM 2613 C5' G B 82 -0.496 23.811 15.684 1.00 1.00 C +ATOM 2614 C4' G B 82 0.452 22.670 15.328 1.00 1.00 C +ATOM 2615 O4' G B 82 0.319 22.356 13.940 1.00 1.00 O +ATOM 2616 C3' G B 82 1.922 22.984 15.591 1.00 1.00 C +ATOM 2617 O3' G B 82 2.325 22.383 16.826 1.00 1.00 O +ATOM 2618 C2' G B 82 2.654 22.322 14.434 1.00 1.00 C +ATOM 2619 O2' G B 82 3.088 21.001 14.773 1.00 1.00 O +ATOM 2620 C1' G B 82 1.612 22.298 13.327 1.00 1.00 C +ATOM 2621 N9 G B 82 1.710 23.433 12.395 1.00 1.00 N +ATOM 2622 C8 G B 82 0.948 24.572 12.347 1.00 1.00 C +ATOM 2623 N7 G B 82 1.281 25.392 11.391 1.00 1.00 N +ATOM 2624 C5 G B 82 2.343 24.753 10.756 1.00 1.00 C +ATOM 2625 C6 G B 82 3.119 25.168 9.639 1.00 1.00 C +ATOM 2626 O6 G B 82 3.017 26.201 8.981 1.00 1.00 O +ATOM 2627 N1 G B 82 4.090 24.231 9.318 1.00 1.00 N +ATOM 2628 C2 G B 82 4.294 23.042 9.986 1.00 1.00 C +ATOM 2629 N2 G B 82 5.278 22.269 9.528 1.00 1.00 N +ATOM 2630 N3 G B 82 3.566 22.650 11.037 1.00 1.00 N +ATOM 2631 C4 G B 82 2.612 23.553 11.364 1.00 1.00 C +ATOM 2632 H5' G B 82 -0.579 23.877 16.768 1.00 1.00 H +ATOM 2633 H5'' G B 82 -0.090 24.747 15.302 1.00 1.00 H +ATOM 2634 H4' G B 82 0.174 21.791 15.906 1.00 1.00 H +ATOM 2635 H3' G B 82 2.095 24.061 15.597 1.00 1.00 H +ATOM 2636 H2' G B 82 3.501 22.939 14.129 1.00 1.00 H +ATOM 2637 HO2' G B 82 4.042 20.980 14.670 1.00 1.00 H +ATOM 2638 H1' G B 82 1.704 21.368 12.766 1.00 1.00 H +ATOM 2639 H8 G B 82 0.134 24.771 13.045 1.00 1.00 H +ATOM 2640 H1 G B 82 4.683 24.456 8.532 1.00 1.00 H +ATOM 2641 H21 G B 82 5.827 22.566 8.734 1.00 1.00 H +ATOM 2642 H22 G B 82 5.475 21.385 9.977 1.00 1.00 H +ATOM 2643 P U B 83 3.183 23.219 17.903 1.00 1.00 P +ATOM 2644 OP1 U B 83 3.385 22.365 19.095 1.00 1.00 O +ATOM 2645 OP2 U B 83 2.564 24.556 18.050 1.00 1.00 O +ATOM 2646 O5' U B 83 4.602 23.400 17.166 1.00 1.00 O +ATOM 2647 C5' U B 83 5.565 22.341 17.166 1.00 1.00 C +ATOM 2648 C4' U B 83 6.820 22.726 16.388 1.00 1.00 C +ATOM 2649 O4' U B 83 6.505 22.854 15.002 1.00 1.00 O +ATOM 2650 C3' U B 83 7.441 24.044 16.830 1.00 1.00 C +ATOM 2651 O3' U B 83 8.475 23.795 17.788 1.00 1.00 O +ATOM 2652 C2' U B 83 8.048 24.600 15.552 1.00 1.00 C +ATOM 2653 O2' U B 83 9.416 24.205 15.409 1.00 1.00 O +ATOM 2654 C1' U B 83 7.179 23.995 14.453 1.00 1.00 C +ATOM 2655 N1 U B 83 6.141 24.913 13.939 1.00 1.00 N +ATOM 2656 C2 U B 83 6.437 25.653 12.811 1.00 1.00 C +ATOM 2657 O2 U B 83 7.522 25.568 12.239 1.00 1.00 O +ATOM 2658 N3 U B 83 5.440 26.500 12.361 1.00 1.00 N +ATOM 2659 C4 U B 83 4.191 26.667 12.934 1.00 1.00 C +ATOM 2660 O4 U B 83 3.378 27.451 12.447 1.00 1.00 O +ATOM 2661 C5 U B 83 3.968 25.854 14.108 1.00 1.00 C +ATOM 2662 C6 U B 83 4.930 25.017 14.568 1.00 1.00 C +ATOM 2663 H5' U B 83 5.120 21.457 16.709 1.00 1.00 H +ATOM 2664 H5'' U B 83 5.839 22.110 18.196 1.00 1.00 H +ATOM 2665 H4' U B 83 7.559 21.935 16.500 1.00 1.00 H +ATOM 2666 H3' U B 83 6.682 24.720 17.228 1.00 1.00 H +ATOM 2667 H2' U B 83 7.957 25.688 15.538 1.00 1.00 H +ATOM 2668 HO2' U B 83 9.565 24.020 14.479 1.00 1.00 H +ATOM 2669 H1' U B 83 7.814 23.671 13.628 1.00 1.00 H +ATOM 2670 H3 U B 83 5.642 27.047 11.537 1.00 1.00 H +ATOM 2671 H5 U B 83 3.015 25.915 14.632 1.00 1.00 H +ATOM 2672 H6 U B 83 4.735 24.415 15.455 1.00 1.00 H +ATOM 2673 P C B 84 8.613 24.719 19.102 1.00 1.00 P +ATOM 2674 OP1 C B 84 9.763 24.227 19.894 1.00 1.00 O +ATOM 2675 OP2 C B 84 7.278 24.831 19.731 1.00 1.00 O +ATOM 2676 O5' C B 84 9.003 26.155 18.486 1.00 1.00 O +ATOM 2677 C5' C B 84 10.335 26.415 18.039 1.00 1.00 C +ATOM 2678 C4' C B 84 10.385 27.601 17.079 1.00 1.00 C +ATOM 2679 O4' C B 84 9.450 27.418 16.019 1.00 1.00 O +ATOM 2680 C3' C B 84 10.042 28.935 17.719 1.00 1.00 C +ATOM 2681 O3' C B 84 11.235 29.554 18.213 1.00 1.00 O +ATOM 2682 C2' C B 84 9.482 29.755 16.566 1.00 1.00 C +ATOM 2683 O2' C B 84 10.477 30.624 16.013 1.00 1.00 O +ATOM 2684 C1' C B 84 9.024 28.706 15.550 1.00 1.00 C +ATOM 2685 N1 C B 84 7.559 28.677 15.345 1.00 1.00 N +ATOM 2686 C2 C B 84 7.048 29.458 14.320 1.00 1.00 C +ATOM 2687 O2 C B 84 7.802 30.142 13.632 1.00 1.00 O +ATOM 2688 N3 C B 84 5.702 29.443 14.106 1.00 1.00 N +ATOM 2689 C4 C B 84 4.893 28.694 14.867 1.00 1.00 C +ATOM 2690 N4 C B 84 3.581 28.701 14.631 1.00 1.00 N +ATOM 2691 C5 C B 84 5.417 27.887 15.926 1.00 1.00 C +ATOM 2692 C6 C B 84 6.749 27.908 16.129 1.00 1.00 C +ATOM 2693 H5' C B 84 10.722 25.529 17.533 1.00 1.00 H +ATOM 2694 H5'' C B 84 10.963 26.633 18.904 1.00 1.00 H +ATOM 2695 H4' C B 84 11.384 27.662 16.651 1.00 1.00 H +ATOM 2696 H3' C B 84 9.299 28.811 18.509 1.00 1.00 H +ATOM 2697 H2' C B 84 8.619 30.326 16.913 1.00 1.00 H +ATOM 2698 HO2' C B 84 10.880 30.162 15.273 1.00 1.00 H +ATOM 2699 H1' C B 84 9.511 28.905 14.594 1.00 1.00 H +ATOM 2700 H41 C B 84 3.206 29.273 13.882 1.00 1.00 H +ATOM 2701 H42 C B 84 2.962 28.142 15.199 1.00 1.00 H +ATOM 2702 H5 C B 84 4.761 27.275 16.546 1.00 1.00 H +ATOM 2703 H6 C B 84 7.182 27.306 16.927 1.00 1.00 H +ATOM 2704 P C B 85 11.150 30.855 19.156 1.00 1.00 P +ATOM 2705 OP1 C B 85 12.417 30.963 19.914 1.00 1.00 O +ATOM 2706 OP2 C B 85 9.859 30.818 19.879 1.00 1.00 O +ATOM 2707 O5' C B 85 11.095 32.065 18.092 1.00 1.00 O +ATOM 2708 C5' C B 85 12.242 32.400 17.303 1.00 1.00 C +ATOM 2709 C4' C B 85 11.997 33.655 16.466 1.00 1.00 C +ATOM 2710 O4' C B 85 11.043 33.391 15.440 1.00 1.00 O +ATOM 2711 C3' C B 85 11.459 34.831 17.261 1.00 1.00 C +ATOM 2712 O3' C B 85 12.541 35.615 17.773 1.00 1.00 O +ATOM 2713 C2' C B 85 10.678 35.627 16.230 1.00 1.00 C +ATOM 2714 O2' C B 85 11.488 36.645 15.632 1.00 1.00 O +ATOM 2715 C1' C B 85 10.262 34.573 15.205 1.00 1.00 C +ATOM 2716 N1 C B 85 8.844 34.185 15.296 1.00 1.00 N +ATOM 2717 C2 C B 85 7.906 35.034 14.730 1.00 1.00 C +ATOM 2718 O2 C B 85 8.268 36.070 14.177 1.00 1.00 O +ATOM 2719 N3 C B 85 6.591 34.687 14.808 1.00 1.00 N +ATOM 2720 C4 C B 85 6.214 33.554 15.416 1.00 1.00 C +ATOM 2721 N4 C B 85 4.919 33.244 15.478 1.00 1.00 N +ATOM 2722 C5 C B 85 7.180 32.675 16.001 1.00 1.00 C +ATOM 2723 C6 C B 85 8.478 33.028 15.918 1.00 1.00 C +ATOM 2724 H5' C B 85 12.473 31.567 16.638 1.00 1.00 H +ATOM 2725 H5'' C B 85 13.090 32.574 17.964 1.00 1.00 H +ATOM 2726 H4' C B 85 12.934 33.948 15.996 1.00 1.00 H +ATOM 2727 H3' C B 85 10.802 34.487 18.063 1.00 1.00 H +ATOM 2728 H2' C B 85 9.792 36.062 16.690 1.00 1.00 H +ATOM 2729 HO2' C B 85 11.193 36.745 14.724 1.00 1.00 H +ATOM 2730 H1' C B 85 10.466 34.947 14.204 1.00 1.00 H +ATOM 2731 H41 C B 85 4.236 33.855 15.065 1.00 1.00 H +ATOM 2732 H42 C B 85 4.624 32.391 15.932 1.00 1.00 H +ATOM 2733 H5 C B 85 6.877 31.753 16.497 1.00 1.00 H +ATOM 2734 H6 C B 85 9.241 32.382 16.351 1.00 1.00 H +ATOM 2735 P U B 86 12.331 36.544 19.072 1.00 1.00 P +ATOM 2736 OP1 U B 86 13.567 37.328 19.288 1.00 1.00 O +ATOM 2737 OP2 U B 86 11.792 35.701 20.163 1.00 1.00 O +ATOM 2738 O5' U B 86 11.170 37.554 18.595 1.00 1.00 O +ATOM 2739 C5' U B 86 11.408 38.497 17.546 1.00 1.00 C +ATOM 2740 C4' U B 86 10.159 39.318 17.237 1.00 1.00 C +ATOM 2741 O4' U B 86 9.147 38.478 16.704 1.00 1.00 O +ATOM 2742 C3' U B 86 9.547 40.007 18.447 1.00 1.00 C +ATOM 2743 O3' U B 86 10.096 41.317 18.633 1.00 1.00 O +ATOM 2744 C2' U B 86 8.054 40.062 18.117 1.00 1.00 C +ATOM 2745 O2' U B 86 7.651 41.387 17.754 1.00 1.00 O +ATOM 2746 C1' U B 86 7.880 39.089 16.950 1.00 1.00 C +ATOM 2747 N1 U B 86 6.910 38.010 17.224 1.00 1.00 N +ATOM 2748 C2 U B 86 5.609 38.186 16.792 1.00 1.00 C +ATOM 2749 O2 U B 86 5.250 39.201 16.200 1.00 1.00 O +ATOM 2750 N3 U B 86 4.732 37.153 17.067 1.00 1.00 N +ATOM 2751 C4 U B 86 5.038 35.975 17.728 1.00 1.00 C +ATOM 2752 O4 U B 86 4.176 35.120 17.917 1.00 1.00 O +ATOM 2753 C5 U B 86 6.420 35.876 18.144 1.00 1.00 C +ATOM 2754 C6 U B 86 7.298 36.876 17.886 1.00 1.00 C +ATOM 2755 H5' U B 86 11.712 37.960 16.646 1.00 1.00 H +ATOM 2756 H5'' U B 86 12.210 39.170 17.847 1.00 1.00 H +ATOM 2757 H4' U B 86 10.408 40.070 16.491 1.00 1.00 H +ATOM 2758 H3' U B 86 9.706 39.394 19.340 1.00 1.00 H +ATOM 2759 HO3' U B 86 10.993 41.304 18.287 1.00 1.00 H +ATOM 2760 H2' U B 86 7.473 39.708 18.972 1.00 1.00 H +ATOM 2761 HO2' U B 86 6.733 41.340 17.481 1.00 1.00 H +ATOM 2762 H1' U B 86 7.570 39.640 16.063 1.00 1.00 H +ATOM 2763 H3 U B 86 3.778 37.267 16.757 1.00 1.00 H +ATOM 2764 H5 U B 86 6.759 34.987 18.675 1.00 1.00 H +ATOM 2765 H6 U B 86 8.333 36.776 18.211 1.00 1.00 H +TER 2766 U B 86 +ENDMDL +MODEL 9 +ATOM 1 O5' G A 1 5.709 -39.062 8.107 1.00 1.00 O +ATOM 2 C5' G A 1 6.547 -39.733 7.164 1.00 1.00 C +ATOM 3 C4' G A 1 5.743 -40.243 5.970 1.00 1.00 C +ATOM 4 O4' G A 1 4.933 -41.351 6.376 1.00 1.00 O +ATOM 5 C3' G A 1 4.817 -39.196 5.359 1.00 1.00 C +ATOM 6 O3' G A 1 5.414 -38.652 4.179 1.00 1.00 O +ATOM 7 C2' G A 1 3.570 -39.980 4.989 1.00 1.00 C +ATOM 8 O2' G A 1 3.635 -40.470 3.647 1.00 1.00 O +ATOM 9 C1' G A 1 3.573 -41.117 5.997 1.00 1.00 C +ATOM 10 N9 G A 1 2.827 -40.817 7.225 1.00 1.00 N +ATOM 11 C8 G A 1 3.313 -40.613 8.491 1.00 1.00 C +ATOM 12 N7 G A 1 2.392 -40.360 9.377 1.00 1.00 N +ATOM 13 C5 G A 1 1.206 -40.400 8.648 1.00 1.00 C +ATOM 14 C6 G A 1 -0.135 -40.200 9.079 1.00 1.00 C +ATOM 15 O6 G A 1 -0.543 -39.942 10.210 1.00 1.00 O +ATOM 16 N1 G A 1 -1.032 -40.327 8.027 1.00 1.00 N +ATOM 17 C2 G A 1 -0.686 -40.612 6.722 1.00 1.00 C +ATOM 18 N2 G A 1 -1.690 -40.696 5.849 1.00 1.00 N +ATOM 19 N3 G A 1 0.574 -40.800 6.315 1.00 1.00 N +ATOM 20 C4 G A 1 1.463 -40.679 7.329 1.00 1.00 C +ATOM 21 H5' G A 1 7.037 -40.573 7.661 1.00 1.00 H +ATOM 22 H5'' G A 1 7.307 -39.045 6.805 1.00 1.00 H +ATOM 23 H4' G A 1 6.435 -40.587 5.203 1.00 1.00 H +ATOM 24 H3' G A 1 4.583 -38.414 6.083 1.00 1.00 H +ATOM 25 H2' G A 1 2.682 -39.361 5.134 1.00 1.00 H +ATOM 26 HO2' G A 1 3.892 -41.393 3.693 1.00 1.00 H +ATOM 27 H1' G A 1 3.163 -42.013 5.535 1.00 1.00 H +ATOM 28 H8 G A 1 4.375 -40.658 8.734 1.00 1.00 H +ATOM 29 H1 G A 1 -2.007 -40.198 8.256 1.00 1.00 H +ATOM 30 H21 G A 1 -2.641 -40.553 6.159 1.00 1.00 H +ATOM 31 H22 G A 1 -1.499 -40.902 4.880 1.00 1.00 H +ATOM 32 HO5' G A 1 6.062 -38.176 8.223 1.00 1.00 H +ATOM 33 P G A 2 5.018 -37.178 3.668 1.00 1.00 P +ATOM 34 OP1 G A 2 5.726 -36.924 2.392 1.00 1.00 O +ATOM 35 OP2 G A 2 5.176 -36.237 4.799 1.00 1.00 O +ATOM 36 O5' G A 2 3.446 -37.326 3.352 1.00 1.00 O +ATOM 37 C5' G A 2 2.985 -38.234 2.349 1.00 1.00 C +ATOM 38 C4' G A 2 1.464 -38.379 2.380 1.00 1.00 C +ATOM 39 O4' G A 2 1.028 -38.813 3.668 1.00 1.00 O +ATOM 40 C3' G A 2 0.713 -37.092 2.082 1.00 1.00 C +ATOM 41 O3' G A 2 0.472 -36.996 0.671 1.00 1.00 O +ATOM 42 C2' G A 2 -0.603 -37.256 2.830 1.00 1.00 C +ATOM 43 O2' G A 2 -1.646 -37.701 1.956 1.00 1.00 O +ATOM 44 C1' G A 2 -0.288 -38.293 3.913 1.00 1.00 C +ATOM 45 N9 G A 2 -0.329 -37.757 5.284 1.00 1.00 N +ATOM 46 C8 G A 2 0.702 -37.369 6.103 1.00 1.00 C +ATOM 47 N7 G A 2 0.315 -36.943 7.272 1.00 1.00 N +ATOM 48 C5 G A 2 -1.072 -37.055 7.229 1.00 1.00 C +ATOM 49 C6 G A 2 -2.045 -36.738 8.218 1.00 1.00 C +ATOM 50 O6 G A 2 -1.867 -36.289 9.349 1.00 1.00 O +ATOM 51 N1 G A 2 -3.333 -37.000 7.768 1.00 1.00 N +ATOM 52 C2 G A 2 -3.649 -37.503 6.523 1.00 1.00 C +ATOM 53 N2 G A 2 -4.944 -37.687 6.272 1.00 1.00 N +ATOM 54 N3 G A 2 -2.736 -37.801 5.593 1.00 1.00 N +ATOM 55 C4 G A 2 -1.474 -37.552 6.015 1.00 1.00 C +ATOM 56 H5' G A 2 3.439 -39.210 2.517 1.00 1.00 H +ATOM 57 H5'' G A 2 3.288 -37.864 1.369 1.00 1.00 H +ATOM 58 H4' G A 2 1.170 -39.130 1.650 1.00 1.00 H +ATOM 59 H3' G A 2 1.264 -36.225 2.449 1.00 1.00 H +ATOM 60 H2' G A 2 -0.875 -36.309 3.299 1.00 1.00 H +ATOM 61 HO2' G A 2 -2.054 -36.915 1.579 1.00 1.00 H +ATOM 62 H1' G A 2 -1.009 -39.110 3.843 1.00 1.00 H +ATOM 63 H8 G A 2 1.749 -37.414 5.802 1.00 1.00 H +ATOM 64 H1 G A 2 -4.080 -36.799 8.417 1.00 1.00 H +ATOM 65 H21 G A 2 -5.630 -37.462 6.972 1.00 1.00 H +ATOM 66 H22 G A 2 -5.238 -38.053 5.378 1.00 1.00 H +ATOM 67 P G A 3 0.183 -35.567 -0.019 1.00 1.00 P +ATOM 68 OP1 G A 3 0.581 -35.649 -1.443 1.00 1.00 O +ATOM 69 OP2 G A 3 0.756 -34.514 0.847 1.00 1.00 O +ATOM 70 O5' G A 3 -1.424 -35.455 0.050 1.00 1.00 O +ATOM 71 C5' G A 3 -2.256 -36.374 -0.666 1.00 1.00 C +ATOM 72 C4' G A 3 -3.694 -36.343 -0.159 1.00 1.00 C +ATOM 73 O4' G A 3 -3.704 -36.570 1.252 1.00 1.00 O +ATOM 74 C3' G A 3 -4.409 -35.022 -0.412 1.00 1.00 C +ATOM 75 O3' G A 3 -5.207 -35.127 -1.597 1.00 1.00 O +ATOM 76 C2' G A 3 -5.309 -34.854 0.802 1.00 1.00 C +ATOM 77 O2' G A 3 -6.619 -35.379 0.557 1.00 1.00 O +ATOM 78 C1' G A 3 -4.586 -35.641 1.892 1.00 1.00 C +ATOM 79 N9 G A 3 -3.767 -34.807 2.786 1.00 1.00 N +ATOM 80 C8 G A 3 -2.463 -34.408 2.638 1.00 1.00 C +ATOM 81 N7 G A 3 -2.022 -33.669 3.616 1.00 1.00 N +ATOM 82 C5 G A 3 -3.111 -33.566 4.477 1.00 1.00 C +ATOM 83 C6 G A 3 -3.231 -32.881 5.718 1.00 1.00 C +ATOM 84 O6 G A 3 -2.380 -32.219 6.309 1.00 1.00 O +ATOM 85 N1 G A 3 -4.500 -33.030 6.261 1.00 1.00 N +ATOM 86 C2 G A 3 -5.527 -33.748 5.687 1.00 1.00 C +ATOM 87 N2 G A 3 -6.676 -33.774 6.360 1.00 1.00 N +ATOM 88 N3 G A 3 -5.416 -34.395 4.522 1.00 1.00 N +ATOM 89 C4 G A 3 -4.185 -34.260 3.976 1.00 1.00 C +ATOM 90 H5' G A 3 -1.858 -37.382 -0.546 1.00 1.00 H +ATOM 91 H5'' G A 3 -2.248 -36.112 -1.724 1.00 1.00 H +ATOM 92 H4' G A 3 -4.254 -37.144 -0.639 1.00 1.00 H +ATOM 93 H3' G A 3 -3.696 -34.200 -0.484 1.00 1.00 H +ATOM 94 H2' G A 3 -5.363 -33.799 1.080 1.00 1.00 H +ATOM 95 HO2' G A 3 -6.876 -35.878 1.338 1.00 1.00 H +ATOM 96 H1' G A 3 -5.317 -36.187 2.488 1.00 1.00 H +ATOM 97 H8 G A 3 -1.852 -34.683 1.779 1.00 1.00 H +ATOM 98 H1 G A 3 -4.661 -32.570 7.145 1.00 1.00 H +ATOM 99 H21 G A 3 -6.758 -33.285 7.238 1.00 1.00 H +ATOM 100 H22 G A 3 -7.466 -34.283 5.989 1.00 1.00 H +ATOM 101 P A A 4 -5.144 -33.984 -2.732 1.00 1.00 P +ATOM 102 OP1 A A 4 -5.686 -34.547 -3.987 1.00 1.00 O +ATOM 103 OP2 A A 4 -3.787 -33.390 -2.715 1.00 1.00 O +ATOM 104 O5' A A 4 -6.182 -32.879 -2.186 1.00 1.00 O +ATOM 105 C5' A A 4 -7.588 -33.026 -2.411 1.00 1.00 C +ATOM 106 C4' A A 4 -8.378 -31.886 -1.776 1.00 1.00 C +ATOM 107 O4' A A 4 -8.270 -31.966 -0.355 1.00 1.00 O +ATOM 108 C3' A A 4 -7.902 -30.501 -2.191 1.00 1.00 C +ATOM 109 O3' A A 4 -8.727 -30.010 -3.253 1.00 1.00 O +ATOM 110 C2' A A 4 -8.105 -29.654 -0.944 1.00 1.00 C +ATOM 111 O2' A A 4 -9.380 -29.002 -0.957 1.00 1.00 O +ATOM 112 C1' A A 4 -8.010 -30.669 0.192 1.00 1.00 C +ATOM 113 N9 A A 4 -6.685 -30.725 0.834 1.00 1.00 N +ATOM 114 C8 A A 4 -5.538 -31.324 0.384 1.00 1.00 C +ATOM 115 N7 A A 4 -4.520 -31.184 1.188 1.00 1.00 N +ATOM 116 C5 A A 4 -5.031 -30.438 2.246 1.00 1.00 C +ATOM 117 C6 A A 4 -4.452 -29.953 3.429 1.00 1.00 C +ATOM 118 N6 A A 4 -3.175 -30.156 3.754 1.00 1.00 N +ATOM 119 N1 A A 4 -5.242 -29.250 4.258 1.00 1.00 N +ATOM 120 C2 A A 4 -6.513 -29.050 3.928 1.00 1.00 C +ATOM 121 N3 A A 4 -7.170 -29.452 2.850 1.00 1.00 N +ATOM 122 C4 A A 4 -6.351 -30.154 2.038 1.00 1.00 C +ATOM 123 H5' A A 4 -7.920 -33.970 -1.983 1.00 1.00 H +ATOM 124 H5'' A A 4 -7.779 -33.035 -3.485 1.00 1.00 H +ATOM 125 H4' A A 4 -9.428 -31.992 -2.046 1.00 1.00 H +ATOM 126 H3' A A 4 -6.850 -30.522 -2.481 1.00 1.00 H +ATOM 127 H2' A A 4 -7.298 -28.922 -0.858 1.00 1.00 H +ATOM 128 HO2' A A 4 -10.021 -29.635 -1.288 1.00 1.00 H +ATOM 129 H1' A A 4 -8.761 -30.437 0.944 1.00 1.00 H +ATOM 130 H8 A A 4 -5.480 -31.869 -0.559 1.00 1.00 H +ATOM 131 H61 A A 4 -2.807 -29.785 4.617 1.00 1.00 H +ATOM 132 H62 A A 4 -2.575 -30.683 3.135 1.00 1.00 H +ATOM 133 H2 A A 4 -7.097 -28.473 4.645 1.00 1.00 H +ATOM 134 P U A 5 -8.132 -28.990 -4.348 1.00 1.00 P +ATOM 135 OP1 U A 5 -9.238 -28.567 -5.234 1.00 1.00 O +ATOM 136 OP2 U A 5 -6.911 -29.594 -4.928 1.00 1.00 O +ATOM 137 O5' U A 5 -7.695 -27.726 -3.455 1.00 1.00 O +ATOM 138 C5' U A 5 -8.680 -26.894 -2.838 1.00 1.00 C +ATOM 139 C4' U A 5 -8.048 -25.947 -1.822 1.00 1.00 C +ATOM 140 O4' U A 5 -7.368 -26.704 -0.827 1.00 1.00 O +ATOM 141 C3' U A 5 -7.031 -24.989 -2.419 1.00 1.00 C +ATOM 142 O3' U A 5 -7.675 -23.752 -2.736 1.00 1.00 O +ATOM 143 C2' U A 5 -6.024 -24.771 -1.297 1.00 1.00 C +ATOM 144 O2' U A 5 -6.292 -23.554 -0.589 1.00 1.00 O +ATOM 145 C1' U A 5 -6.204 -25.991 -0.390 1.00 1.00 C +ATOM 146 N1 U A 5 -5.067 -26.937 -0.420 1.00 1.00 N +ATOM 147 C2 U A 5 -4.164 -26.883 0.627 1.00 1.00 C +ATOM 148 O2 U A 5 -4.287 -26.088 1.555 1.00 1.00 O +ATOM 149 N3 U A 5 -3.112 -27.779 0.567 1.00 1.00 N +ATOM 150 C4 U A 5 -2.888 -28.711 -0.432 1.00 1.00 C +ATOM 151 O4 U A 5 -1.916 -29.461 -0.383 1.00 1.00 O +ATOM 152 C5 U A 5 -3.881 -28.696 -1.484 1.00 1.00 C +ATOM 153 C6 U A 5 -4.919 -27.827 -1.447 1.00 1.00 C +ATOM 154 H5' U A 5 -9.411 -27.523 -2.332 1.00 1.00 H +ATOM 155 H5'' U A 5 -9.184 -26.309 -3.607 1.00 1.00 H +ATOM 156 H4' U A 5 -8.834 -25.373 -1.338 1.00 1.00 H +ATOM 157 H3' U A 5 -6.551 -25.424 -3.298 1.00 1.00 H +ATOM 158 H2' U A 5 -5.011 -24.760 -1.707 1.00 1.00 H +ATOM 159 HO2' U A 5 -7.180 -23.619 -0.232 1.00 1.00 H +ATOM 160 H1' U A 5 -6.364 -25.652 0.633 1.00 1.00 H +ATOM 161 H3 U A 5 -2.444 -27.752 1.325 1.00 1.00 H +ATOM 162 H5 U A 5 -3.791 -29.393 -2.317 1.00 1.00 H +ATOM 163 H6 U A 5 -5.654 -27.840 -2.252 1.00 1.00 H +ATOM 164 P A A 6 -7.260 -22.924 -4.054 1.00 1.00 P +ATOM 165 OP1 A A 6 -8.049 -23.443 -5.193 1.00 1.00 O +ATOM 166 OP2 A A 6 -5.783 -22.886 -4.134 1.00 1.00 O +ATOM 167 O5' A A 6 -7.785 -21.442 -3.710 1.00 1.00 O +ATOM 168 C5' A A 6 -8.919 -21.261 -2.860 1.00 1.00 C +ATOM 169 C4' A A 6 -8.547 -20.520 -1.578 1.00 1.00 C +ATOM 170 O4' A A 6 -7.260 -20.963 -1.134 1.00 1.00 O +ATOM 171 C3' A A 6 -8.487 -18.997 -1.731 1.00 1.00 C +ATOM 172 O3' A A 6 -9.331 -18.389 -0.748 1.00 1.00 O +ATOM 173 C2' A A 6 -7.033 -18.627 -1.450 1.00 1.00 C +ATOM 174 O2' A A 6 -6.943 -17.442 -0.651 1.00 1.00 O +ATOM 175 C1' A A 6 -6.498 -19.837 -0.701 1.00 1.00 C +ATOM 176 N9 A A 6 -5.071 -20.128 -0.956 1.00 1.00 N +ATOM 177 C8 A A 6 -4.420 -20.260 -2.156 1.00 1.00 C +ATOM 178 N7 A A 6 -3.148 -20.523 -2.040 1.00 1.00 N +ATOM 179 C5 A A 6 -2.941 -20.567 -0.665 1.00 1.00 C +ATOM 180 C6 A A 6 -1.798 -20.805 0.115 1.00 1.00 C +ATOM 181 N6 A A 6 -0.596 -21.056 -0.407 1.00 1.00 N +ATOM 182 N1 A A 6 -1.945 -20.775 1.451 1.00 1.00 N +ATOM 183 C2 A A 6 -3.144 -20.527 1.965 1.00 1.00 C +ATOM 184 N3 A A 6 -4.288 -20.290 1.341 1.00 1.00 N +ATOM 185 C4 A A 6 -4.107 -20.327 0.003 1.00 1.00 C +ATOM 186 H5' A A 6 -9.330 -22.237 -2.600 1.00 1.00 H +ATOM 187 H5'' A A 6 -9.677 -20.688 -3.396 1.00 1.00 H +ATOM 188 H4' A A 6 -9.277 -20.765 -0.808 1.00 1.00 H +ATOM 189 H3' A A 6 -8.774 -18.694 -2.739 1.00 1.00 H +ATOM 190 H2' A A 6 -6.492 -18.501 -2.390 1.00 1.00 H +ATOM 191 HO2' A A 6 -6.281 -16.875 -1.054 1.00 1.00 H +ATOM 192 H1' A A 6 -6.647 -19.693 0.369 1.00 1.00 H +ATOM 193 H8 A A 6 -4.920 -20.150 -3.119 1.00 1.00 H +ATOM 194 H61 A A 6 0.188 -21.219 0.202 1.00 1.00 H +ATOM 195 H62 A A 6 -0.472 -21.081 -1.407 1.00 1.00 H +ATOM 196 H2 A A 6 -3.193 -20.514 3.054 1.00 1.00 H +ATOM 197 P U A 7 -9.498 -16.788 -0.695 1.00 1.00 P +ATOM 198 OP1 U A 7 -10.919 -16.478 -0.422 1.00 1.00 O +ATOM 199 OP2 U A 7 -8.834 -16.215 -1.888 1.00 1.00 O +ATOM 200 O5' U A 7 -8.635 -16.387 0.602 1.00 1.00 O +ATOM 201 C5' U A 7 -9.285 -16.034 1.825 1.00 1.00 C +ATOM 202 C4' U A 7 -8.487 -16.500 3.038 1.00 1.00 C +ATOM 203 O4' U A 7 -8.753 -17.886 3.272 1.00 1.00 O +ATOM 204 C3' U A 7 -6.973 -16.336 2.880 1.00 1.00 C +ATOM 205 O3' U A 7 -6.449 -15.554 3.956 1.00 1.00 O +ATOM 206 C2' U A 7 -6.416 -17.746 2.977 1.00 1.00 C +ATOM 207 O2' U A 7 -5.232 -17.789 3.776 1.00 1.00 O +ATOM 208 C1' U A 7 -7.539 -18.537 3.626 1.00 1.00 C +ATOM 209 N1 U A 7 -7.620 -19.943 3.181 1.00 1.00 N +ATOM 210 C2 U A 7 -8.864 -20.544 3.180 1.00 1.00 C +ATOM 211 O2 U A 7 -9.879 -19.946 3.533 1.00 1.00 O +ATOM 212 N3 U A 7 -8.903 -21.861 2.759 1.00 1.00 N +ATOM 213 C4 U A 7 -7.821 -22.618 2.342 1.00 1.00 C +ATOM 214 O4 U A 7 -7.972 -23.786 1.989 1.00 1.00 O +ATOM 215 C5 U A 7 -6.561 -21.910 2.374 1.00 1.00 C +ATOM 216 C6 U A 7 -6.498 -20.619 2.784 1.00 1.00 C +ATOM 217 H5' U A 7 -10.272 -16.495 1.851 1.00 1.00 H +ATOM 218 H5'' U A 7 -9.395 -14.950 1.868 1.00 1.00 H +ATOM 219 H4' U A 7 -8.812 -15.933 3.909 1.00 1.00 H +ATOM 220 H3' U A 7 -6.725 -15.890 1.915 1.00 1.00 H +ATOM 221 H2' U A 7 -6.219 -18.130 1.974 1.00 1.00 H +ATOM 222 HO2' U A 7 -5.507 -17.953 4.681 1.00 1.00 H +ATOM 223 H1' U A 7 -7.418 -18.509 4.708 1.00 1.00 H +ATOM 224 H3 U A 7 -9.806 -22.313 2.754 1.00 1.00 H +ATOM 225 H5 U A 7 -5.649 -22.421 2.065 1.00 1.00 H +ATOM 226 H6 U A 7 -5.534 -20.110 2.797 1.00 1.00 H +ATOM 227 P G A 8 -5.139 -14.648 3.730 1.00 1.00 P +ATOM 228 OP1 G A 8 -4.589 -14.295 5.057 1.00 1.00 O +ATOM 229 OP2 G A 8 -5.476 -13.581 2.761 1.00 1.00 O +ATOM 230 O5' G A 8 -4.116 -15.669 3.018 1.00 1.00 O +ATOM 231 C5' G A 8 -3.144 -16.383 3.787 1.00 1.00 C +ATOM 232 C4' G A 8 -1.795 -16.410 3.082 1.00 1.00 C +ATOM 233 O4' G A 8 -1.772 -17.454 2.110 1.00 1.00 O +ATOM 234 C3' G A 8 -1.473 -15.117 2.361 1.00 1.00 C +ATOM 235 O3' G A 8 -0.685 -14.279 3.213 1.00 1.00 O +ATOM 236 C2' G A 8 -0.656 -15.556 1.158 1.00 1.00 C +ATOM 237 O2' G A 8 0.746 -15.409 1.395 1.00 1.00 O +ATOM 238 C1' G A 8 -1.034 -17.017 0.959 1.00 1.00 C +ATOM 239 N9 G A 8 -1.884 -17.244 -0.222 1.00 1.00 N +ATOM 240 C8 G A 8 -3.240 -17.436 -0.264 1.00 1.00 C +ATOM 241 N7 G A 8 -3.714 -17.609 -1.465 1.00 1.00 N +ATOM 242 C5 G A 8 -2.593 -17.530 -2.285 1.00 1.00 C +ATOM 243 C6 G A 8 -2.491 -17.643 -3.698 1.00 1.00 C +ATOM 244 O6 G A 8 -3.390 -17.836 -4.514 1.00 1.00 O +ATOM 245 N1 G A 8 -1.179 -17.504 -4.128 1.00 1.00 N +ATOM 246 C2 G A 8 -0.096 -17.282 -3.304 1.00 1.00 C +ATOM 247 N2 G A 8 1.089 -17.179 -3.906 1.00 1.00 N +ATOM 248 N3 G A 8 -0.188 -17.173 -1.972 1.00 1.00 N +ATOM 249 C4 G A 8 -1.464 -17.307 -1.534 1.00 1.00 C +ATOM 250 H5' G A 8 -3.488 -17.405 3.934 1.00 1.00 H +ATOM 251 H5'' G A 8 -3.031 -15.900 4.757 1.00 1.00 H +ATOM 252 H4' G A 8 -1.017 -16.605 3.816 1.00 1.00 H +ATOM 253 H3' G A 8 -2.388 -14.610 2.047 1.00 1.00 H +ATOM 254 H2' G A 8 -0.963 -14.986 0.284 1.00 1.00 H +ATOM 255 HO2' G A 8 1.096 -16.278 1.597 1.00 1.00 H +ATOM 256 H1' G A 8 -0.128 -17.617 0.865 1.00 1.00 H +ATOM 257 H8 G A 8 -3.866 -17.448 0.628 1.00 1.00 H +ATOM 258 H1 G A 8 -1.029 -17.573 -5.125 1.00 1.00 H +ATOM 259 H21 G A 8 1.152 -17.261 -4.904 1.00 1.00 H +ATOM 260 H22 G A 8 1.918 -17.018 -3.361 1.00 1.00 H +ATOM 261 P G A 9 -0.893 -12.682 3.207 1.00 1.00 P +ATOM 262 OP1 G A 9 -0.096 -12.106 4.314 1.00 1.00 O +ATOM 263 OP2 G A 9 -2.344 -12.405 3.121 1.00 1.00 O +ATOM 264 O5' G A 9 -0.213 -12.244 1.813 1.00 1.00 O +ATOM 265 C5' G A 9 -1.016 -11.733 0.746 1.00 1.00 C +ATOM 266 C4' G A 9 -0.171 -11.366 -0.472 1.00 1.00 C +ATOM 267 O4' G A 9 0.098 -12.540 -1.242 1.00 1.00 O +ATOM 268 C3' G A 9 -0.838 -10.366 -1.404 1.00 1.00 C +ATOM 269 O3' G A 9 -0.416 -9.039 -1.069 1.00 1.00 O +ATOM 270 C2' G A 9 -0.312 -10.746 -2.776 1.00 1.00 C +ATOM 271 O2' G A 9 0.875 -10.016 -3.103 1.00 1.00 O +ATOM 272 C1' G A 9 -0.027 -12.238 -2.641 1.00 1.00 C +ATOM 273 N9 G A 9 -1.094 -13.098 -3.183 1.00 1.00 N +ATOM 274 C8 G A 9 -2.015 -13.852 -2.502 1.00 1.00 C +ATOM 275 N7 G A 9 -2.838 -14.504 -3.275 1.00 1.00 N +ATOM 276 C5 G A 9 -2.436 -14.159 -4.562 1.00 1.00 C +ATOM 277 C6 G A 9 -2.961 -14.563 -5.821 1.00 1.00 C +ATOM 278 O6 G A 9 -3.905 -15.319 -6.047 1.00 1.00 O +ATOM 279 N1 G A 9 -2.264 -13.985 -6.873 1.00 1.00 N +ATOM 280 C2 G A 9 -1.195 -13.126 -6.736 1.00 1.00 C +ATOM 281 N2 G A 9 -0.653 -12.674 -7.868 1.00 1.00 N +ATOM 282 N3 G A 9 -0.699 -12.745 -5.555 1.00 1.00 N +ATOM 283 C4 G A 9 -1.368 -13.299 -4.516 1.00 1.00 C +ATOM 284 H5' G A 9 -1.545 -10.845 1.091 1.00 1.00 H +ATOM 285 H5'' G A 9 -1.743 -12.490 0.455 1.00 1.00 H +ATOM 286 H4' G A 9 0.777 -10.953 -0.134 1.00 1.00 H +ATOM 287 H3' G A 9 -1.925 -10.458 -1.362 1.00 1.00 H +ATOM 288 H2' G A 9 -1.086 -10.585 -3.529 1.00 1.00 H +ATOM 289 HO2' G A 9 0.915 -9.954 -4.062 1.00 1.00 H +ATOM 290 H1' G A 9 0.910 -12.472 -3.144 1.00 1.00 H +ATOM 291 H8 G A 9 -2.054 -13.903 -1.414 1.00 1.00 H +ATOM 292 H1 G A 9 -2.581 -14.226 -7.801 1.00 1.00 H +ATOM 293 H21 G A 9 -1.029 -12.963 -8.759 1.00 1.00 H +ATOM 294 H22 G A 9 0.134 -12.040 -7.832 1.00 1.00 H +ATOM 295 P A A 10 -1.449 -7.804 -1.155 1.00 1.00 P +ATOM 296 OP1 A A 10 -0.790 -6.610 -0.578 1.00 1.00 O +ATOM 297 OP2 A A 10 -2.754 -8.254 -0.623 1.00 1.00 O +ATOM 298 O5' A A 10 -1.606 -7.571 -2.741 1.00 1.00 O +ATOM 299 C5' A A 10 -0.528 -7.021 -3.498 1.00 1.00 C +ATOM 300 C4' A A 10 -0.824 -7.028 -4.996 1.00 1.00 C +ATOM 301 O4' A A 10 -0.906 -8.362 -5.480 1.00 1.00 O +ATOM 302 C3' A A 10 -2.133 -6.358 -5.376 1.00 1.00 C +ATOM 303 O3' A A 10 -1.914 -4.960 -5.599 1.00 1.00 O +ATOM 304 C2' A A 10 -2.517 -7.043 -6.679 1.00 1.00 C +ATOM 305 O2' A A 10 -2.099 -6.281 -7.817 1.00 1.00 O +ATOM 306 C1' A A 10 -1.789 -8.386 -6.612 1.00 1.00 C +ATOM 307 N9 A A 10 -2.685 -9.541 -6.458 1.00 1.00 N +ATOM 308 C8 A A 10 -3.210 -10.083 -5.313 1.00 1.00 C +ATOM 309 N7 A A 10 -3.971 -11.123 -5.521 1.00 1.00 N +ATOM 310 C5 A A 10 -3.949 -11.279 -6.904 1.00 1.00 C +ATOM 311 C6 A A 10 -4.560 -12.207 -7.763 1.00 1.00 C +ATOM 312 N6 A A 10 -5.347 -13.195 -7.332 1.00 1.00 N +ATOM 313 N1 A A 10 -4.329 -12.074 -9.080 1.00 1.00 N +ATOM 314 C2 A A 10 -3.543 -11.090 -9.503 1.00 1.00 C +ATOM 315 N3 A A 10 -2.915 -10.161 -8.799 1.00 1.00 N +ATOM 316 C4 A A 10 -3.168 -10.320 -7.483 1.00 1.00 C +ATOM 317 H5' A A 10 0.369 -7.609 -3.310 1.00 1.00 H +ATOM 318 H5'' A A 10 -0.355 -5.995 -3.176 1.00 1.00 H +ATOM 319 H4' A A 10 -0.011 -6.527 -5.516 1.00 1.00 H +ATOM 320 H3' A A 10 -2.892 -6.525 -4.611 1.00 1.00 H +ATOM 321 H2' A A 10 -3.597 -7.211 -6.704 1.00 1.00 H +ATOM 322 HO2' A A 10 -1.376 -6.757 -8.230 1.00 1.00 H +ATOM 323 H1' A A 10 -1.199 -8.516 -7.519 1.00 1.00 H +ATOM 324 H8 A A 10 -3.010 -9.682 -4.318 1.00 1.00 H +ATOM 325 H61 A A 10 -5.761 -13.832 -7.993 1.00 1.00 H +ATOM 326 H62 A A 10 -5.528 -13.301 -6.345 1.00 1.00 H +ATOM 327 H2 A A 10 -3.398 -11.040 -10.583 1.00 1.00 H +ATOM 328 P A A 11 -3.146 -3.923 -5.559 1.00 1.00 P +ATOM 329 OP1 A A 11 -2.614 -2.582 -5.232 1.00 1.00 O +ATOM 330 OP2 A A 11 -4.220 -4.513 -4.728 1.00 1.00 O +ATOM 331 O5' A A 11 -3.647 -3.909 -7.092 1.00 1.00 O +ATOM 332 C5' A A 11 -2.825 -3.354 -8.123 1.00 1.00 C +ATOM 333 C4' A A 11 -3.346 -3.713 -9.512 1.00 1.00 C +ATOM 334 O4' A A 11 -3.480 -5.132 -9.621 1.00 1.00 O +ATOM 335 C3' A A 11 -4.706 -3.115 -9.840 1.00 1.00 C +ATOM 336 O3' A A 11 -4.532 -1.861 -10.510 1.00 1.00 O +ATOM 337 C2' A A 11 -5.313 -4.136 -10.789 1.00 1.00 C +ATOM 338 O2' A A 11 -4.982 -3.849 -12.153 1.00 1.00 O +ATOM 339 C1' A A 11 -4.692 -5.446 -10.325 1.00 1.00 C +ATOM 340 N9 A A 11 -5.556 -6.208 -9.410 1.00 1.00 N +ATOM 341 C8 A A 11 -5.600 -6.180 -8.041 1.00 1.00 C +ATOM 342 N7 A A 11 -6.489 -6.984 -7.525 1.00 1.00 N +ATOM 343 C5 A A 11 -7.074 -7.589 -8.634 1.00 1.00 C +ATOM 344 C6 A A 11 -8.092 -8.547 -8.767 1.00 1.00 C +ATOM 345 N6 A A 11 -8.726 -9.087 -7.725 1.00 1.00 N +ATOM 346 N1 A A 11 -8.427 -8.922 -10.013 1.00 1.00 N +ATOM 347 C2 A A 11 -7.793 -8.380 -11.045 1.00 1.00 C +ATOM 348 N3 A A 11 -6.824 -7.476 -11.050 1.00 1.00 N +ATOM 349 C4 A A 11 -6.511 -7.121 -9.787 1.00 1.00 C +ATOM 350 H5' A A 11 -1.811 -3.736 -8.015 1.00 1.00 H +ATOM 351 H5'' A A 11 -2.809 -2.269 -8.019 1.00 1.00 H +ATOM 352 H4' A A 11 -2.626 -3.378 -10.256 1.00 1.00 H +ATOM 353 H3' A A 11 -5.314 -3.007 -8.940 1.00 1.00 H +ATOM 354 H2' A A 11 -6.393 -4.177 -10.654 1.00 1.00 H +ATOM 355 HO2' A A 11 -4.325 -3.150 -12.147 1.00 1.00 H +ATOM 356 H1' A A 11 -4.457 -6.065 -11.192 1.00 1.00 H +ATOM 357 H8 A A 11 -4.955 -5.542 -7.437 1.00 1.00 H +ATOM 358 H61 A A 11 -9.454 -9.774 -7.875 1.00 1.00 H +ATOM 359 H62 A A 11 -8.483 -8.810 -6.787 1.00 1.00 H +ATOM 360 H2 A A 11 -8.114 -8.729 -12.027 1.00 1.00 H +ATOM 361 P G A 12 -5.376 -0.564 -10.055 1.00 1.00 P +ATOM 362 OP1 G A 12 -4.796 0.625 -10.719 1.00 1.00 O +ATOM 363 OP2 G A 12 -5.508 -0.593 -8.582 1.00 1.00 O +ATOM 364 O5' G A 12 -6.829 -0.839 -10.693 1.00 1.00 O +ATOM 365 C5' G A 12 -7.086 -0.538 -12.067 1.00 1.00 C +ATOM 366 C4' G A 12 -8.459 -1.042 -12.510 1.00 1.00 C +ATOM 367 O4' G A 12 -8.521 -2.465 -12.416 1.00 1.00 O +ATOM 368 C3' G A 12 -9.621 -0.506 -11.687 1.00 1.00 C +ATOM 369 O3' G A 12 -10.094 0.716 -12.267 1.00 1.00 O +ATOM 370 C2' G A 12 -10.678 -1.588 -11.837 1.00 1.00 C +ATOM 371 O2' G A 12 -11.563 -1.312 -12.928 1.00 1.00 O +ATOM 372 C1' G A 12 -9.866 -2.851 -12.075 1.00 1.00 C +ATOM 373 N9 G A 12 -9.826 -3.753 -10.910 1.00 1.00 N +ATOM 374 C8 G A 12 -8.935 -3.794 -9.869 1.00 1.00 C +ATOM 375 N7 G A 12 -9.178 -4.735 -9.000 1.00 1.00 N +ATOM 376 C5 G A 12 -10.315 -5.366 -9.500 1.00 1.00 C +ATOM 377 C6 G A 12 -11.047 -6.469 -8.981 1.00 1.00 C +ATOM 378 O6 G A 12 -10.830 -7.117 -7.959 1.00 1.00 O +ATOM 379 N1 G A 12 -12.128 -6.791 -9.792 1.00 1.00 N +ATOM 380 C2 G A 12 -12.463 -6.135 -10.957 1.00 1.00 C +ATOM 381 N2 G A 12 -13.540 -6.587 -11.599 1.00 1.00 N +ATOM 382 N3 G A 12 -11.776 -5.098 -11.448 1.00 1.00 N +ATOM 383 C4 G A 12 -10.718 -4.771 -10.669 1.00 1.00 C +ATOM 384 H5' G A 12 -6.319 -1.006 -12.683 1.00 1.00 H +ATOM 385 H5'' G A 12 -7.043 0.543 -12.208 1.00 1.00 H +ATOM 386 H4' G A 12 -8.611 -0.764 -13.551 1.00 1.00 H +ATOM 387 H3' G A 12 -9.336 -0.373 -10.643 1.00 1.00 H +ATOM 388 H2' G A 12 -11.233 -1.697 -10.903 1.00 1.00 H +ATOM 389 HO2' G A 12 -11.138 -0.654 -13.482 1.00 1.00 H +ATOM 390 H1' G A 12 -10.298 -3.390 -12.919 1.00 1.00 H +ATOM 391 H8 G A 12 -8.100 -3.100 -9.775 1.00 1.00 H +ATOM 392 H1 G A 12 -12.697 -7.566 -9.487 1.00 1.00 H +ATOM 393 H21 G A 12 -14.059 -7.367 -11.227 1.00 1.00 H +ATOM 394 H22 G A 12 -13.837 -6.145 -12.460 1.00 1.00 H +ATOM 395 P A A 13 -11.135 1.656 -11.472 1.00 1.00 P +ATOM 396 OP1 A A 13 -11.125 2.996 -12.102 1.00 1.00 O +ATOM 397 OP2 A A 13 -10.864 1.522 -10.024 1.00 1.00 O +ATOM 398 O5' A A 13 -12.555 0.961 -11.789 1.00 1.00 O +ATOM 399 C5' A A 13 -13.130 1.032 -13.099 1.00 1.00 C +ATOM 400 C4' A A 13 -14.309 0.074 -13.252 1.00 1.00 C +ATOM 401 O4' A A 13 -13.920 -1.243 -12.845 1.00 1.00 O +ATOM 402 C3' A A 13 -15.523 0.444 -12.414 1.00 1.00 C +ATOM 403 O3' A A 13 -16.403 1.288 -13.171 1.00 1.00 O +ATOM 404 C2' A A 13 -16.183 -0.898 -12.150 1.00 1.00 C +ATOM 405 O2' A A 13 -17.139 -1.225 -13.163 1.00 1.00 O +ATOM 406 C1' A A 13 -15.011 -1.872 -12.147 1.00 1.00 C +ATOM 407 N9 A A 13 -14.545 -2.212 -10.792 1.00 1.00 N +ATOM 408 C8 A A 13 -13.630 -1.558 -10.007 1.00 1.00 C +ATOM 409 N7 A A 13 -13.429 -2.125 -8.849 1.00 1.00 N +ATOM 410 C5 A A 13 -14.270 -3.234 -8.870 1.00 1.00 C +ATOM 411 C6 A A 13 -14.527 -4.249 -7.933 1.00 1.00 C +ATOM 412 N6 A A 13 -13.932 -4.312 -6.742 1.00 1.00 N +ATOM 413 N1 A A 13 -15.419 -5.193 -8.277 1.00 1.00 N +ATOM 414 C2 A A 13 -16.010 -5.126 -9.465 1.00 1.00 C +ATOM 415 N3 A A 13 -15.855 -4.227 -10.425 1.00 1.00 N +ATOM 416 C4 A A 13 -14.954 -3.294 -10.051 1.00 1.00 C +ATOM 417 H5' A A 13 -12.368 0.779 -13.836 1.00 1.00 H +ATOM 418 H5'' A A 13 -13.475 2.049 -13.278 1.00 1.00 H +ATOM 419 H4' A A 13 -14.604 0.039 -14.301 1.00 1.00 H +ATOM 420 H3' A A 13 -15.220 0.921 -11.481 1.00 1.00 H +ATOM 421 H2' A A 13 -16.649 -0.893 -11.169 1.00 1.00 H +ATOM 422 HO2' A A 13 -17.752 -1.858 -12.779 1.00 1.00 H +ATOM 423 H1' A A 13 -15.291 -2.793 -12.665 1.00 1.00 H +ATOM 424 H8 A A 13 -13.120 -0.648 -10.320 1.00 1.00 H +ATOM 425 H61 A A 13 -14.153 -5.067 -6.104 1.00 1.00 H +ATOM 426 H62 A A 13 -13.259 -3.607 -6.475 1.00 1.00 H +ATOM 427 H2 A A 13 -16.723 -5.922 -9.679 1.00 1.00 H +ATOM 428 P A A 14 -17.025 2.624 -12.512 1.00 1.00 P +ATOM 429 OP1 A A 14 -17.582 3.462 -13.598 1.00 1.00 O +ATOM 430 OP2 A A 14 -16.018 3.195 -11.589 1.00 1.00 O +ATOM 431 O5' A A 14 -18.252 2.062 -11.630 1.00 1.00 O +ATOM 432 C5' A A 14 -19.519 1.786 -12.237 1.00 1.00 C +ATOM 433 C4' A A 14 -20.475 1.102 -11.264 1.00 1.00 C +ATOM 434 O4' A A 14 -19.950 -0.174 -10.890 1.00 1.00 O +ATOM 435 C3' A A 14 -20.707 1.874 -9.977 1.00 1.00 C +ATOM 436 O3' A A 14 -21.850 2.726 -10.117 1.00 1.00 O +ATOM 437 C2' A A 14 -20.998 0.778 -8.966 1.00 1.00 C +ATOM 438 O2' A A 14 -22.393 0.462 -8.923 1.00 1.00 O +ATOM 439 C1' A A 14 -20.171 -0.391 -9.485 1.00 1.00 C +ATOM 440 N9 A A 14 -18.852 -0.505 -8.842 1.00 1.00 N +ATOM 441 C8 A A 14 -17.689 0.153 -9.153 1.00 1.00 C +ATOM 442 N7 A A 14 -16.678 -0.179 -8.398 1.00 1.00 N +ATOM 443 C5 A A 14 -17.209 -1.124 -7.525 1.00 1.00 C +ATOM 444 C6 A A 14 -16.648 -1.866 -6.473 1.00 1.00 C +ATOM 445 N6 A A 14 -15.368 -1.765 -6.109 1.00 1.00 N +ATOM 446 N1 A A 14 -17.458 -2.712 -5.815 1.00 1.00 N +ATOM 447 C2 A A 14 -18.729 -2.808 -6.181 1.00 1.00 C +ATOM 448 N3 A A 14 -19.372 -2.169 -7.147 1.00 1.00 N +ATOM 449 C4 A A 14 -18.533 -1.328 -7.789 1.00 1.00 C +ATOM 450 H5' A A 14 -19.365 1.137 -13.098 1.00 1.00 H +ATOM 451 H5'' A A 14 -19.965 2.722 -12.571 1.00 1.00 H +ATOM 452 H4' A A 14 -21.433 0.947 -11.759 1.00 1.00 H +ATOM 453 H3' A A 14 -19.817 2.440 -9.696 1.00 1.00 H +ATOM 454 H2' A A 14 -20.638 1.075 -7.984 1.00 1.00 H +ATOM 455 HO2' A A 14 -22.507 -0.386 -9.356 1.00 1.00 H +ATOM 456 H1' A A 14 -20.722 -1.322 -9.343 1.00 1.00 H +ATOM 457 H8 A A 14 -17.618 0.887 -9.955 1.00 1.00 H +ATOM 458 H61 A A 14 -15.017 -2.325 -5.342 1.00 1.00 H +ATOM 459 H62 A A 14 -14.751 -1.132 -6.598 1.00 1.00 H +ATOM 460 H2 A A 14 -19.331 -3.512 -5.605 1.00 1.00 H +ATOM 461 P C A 15 -21.885 4.174 -9.410 1.00 1.00 P +ATOM 462 OP1 C A 15 -23.162 4.834 -9.767 1.00 1.00 O +ATOM 463 OP2 C A 15 -20.602 4.857 -9.688 1.00 1.00 O +ATOM 464 O5' C A 15 -21.931 3.809 -7.841 1.00 1.00 O +ATOM 465 C5' C A 15 -23.167 3.465 -7.209 1.00 1.00 C +ATOM 466 C4' C A 15 -22.952 2.993 -5.774 1.00 1.00 C +ATOM 467 O4' C A 15 -22.157 1.810 -5.762 1.00 1.00 O +ATOM 468 C3' C A 15 -22.229 3.990 -4.890 1.00 1.00 C +ATOM 469 O3' C A 15 -23.166 4.889 -4.286 1.00 1.00 O +ATOM 470 C2' C A 15 -21.593 3.110 -3.826 1.00 1.00 C +ATOM 471 O2' C A 15 -22.443 2.976 -2.683 1.00 1.00 O +ATOM 472 C1' C A 15 -21.400 1.772 -4.538 1.00 1.00 C +ATOM 473 N1 C A 15 -19.991 1.486 -4.888 1.00 1.00 N +ATOM 474 C2 C A 15 -19.282 0.622 -4.068 1.00 1.00 C +ATOM 475 O2 C A 15 -19.826 0.116 -3.089 1.00 1.00 O +ATOM 476 N3 C A 15 -17.983 0.357 -4.381 1.00 1.00 N +ATOM 477 C4 C A 15 -17.405 0.917 -5.453 1.00 1.00 C +ATOM 478 N4 C A 15 -16.131 0.637 -5.731 1.00 1.00 N +ATOM 479 C5 C A 15 -18.134 1.808 -6.301 1.00 1.00 C +ATOM 480 C6 C A 15 -19.419 2.063 -5.983 1.00 1.00 C +ATOM 481 H5' C A 15 -23.646 2.669 -7.777 1.00 1.00 H +ATOM 482 H5'' C A 15 -23.817 4.339 -7.203 1.00 1.00 H +ATOM 483 H4' C A 15 -23.919 2.762 -5.329 1.00 1.00 H +ATOM 484 H3' C A 15 -21.467 4.530 -5.454 1.00 1.00 H +ATOM 485 H2' C A 15 -20.624 3.517 -3.540 1.00 1.00 H +ATOM 486 HO2' C A 15 -22.727 2.060 -2.642 1.00 1.00 H +ATOM 487 H1' C A 15 -21.785 0.975 -3.906 1.00 1.00 H +ATOM 488 H41 C A 15 -15.612 0.012 -5.140 1.00 1.00 H +ATOM 489 H42 C A 15 -15.688 1.054 -6.536 1.00 1.00 H +ATOM 490 H5 C A 15 -17.668 2.263 -7.175 1.00 1.00 H +ATOM 491 H6 C A 15 -20.005 2.738 -6.607 1.00 1.00 H +ATOM 492 P C A 16 -22.677 6.323 -3.739 1.00 1.00 P +ATOM 493 OP1 C A 16 -23.842 7.017 -3.144 1.00 1.00 O +ATOM 494 OP2 C A 16 -21.889 6.984 -4.804 1.00 1.00 O +ATOM 495 O5' C A 16 -21.673 5.913 -2.550 1.00 1.00 O +ATOM 496 C5' C A 16 -22.171 5.275 -1.372 1.00 1.00 C +ATOM 497 C4' C A 16 -21.070 4.509 -0.639 1.00 1.00 C +ATOM 498 O4' C A 16 -20.379 3.657 -1.550 1.00 1.00 O +ATOM 499 C3' C A 16 -20.005 5.383 0.005 1.00 1.00 C +ATOM 500 O3' C A 16 -20.385 5.690 1.350 1.00 1.00 O +ATOM 501 C2' C A 16 -18.772 4.492 0.023 1.00 1.00 C +ATOM 502 O2' C A 16 -18.602 3.857 1.294 1.00 1.00 O +ATOM 503 C1' C A 16 -19.037 3.467 -1.074 1.00 1.00 C +ATOM 504 N1 C A 16 -18.096 3.556 -2.219 1.00 1.00 N +ATOM 505 C2 C A 16 -17.038 2.660 -2.236 1.00 1.00 C +ATOM 506 O2 C A 16 -16.898 1.857 -1.318 1.00 1.00 O +ATOM 507 N3 C A 16 -16.174 2.703 -3.287 1.00 1.00 N +ATOM 508 C4 C A 16 -16.340 3.587 -4.280 1.00 1.00 C +ATOM 509 N4 C A 16 -15.476 3.599 -5.295 1.00 1.00 N +ATOM 510 C5 C A 16 -17.428 4.516 -4.264 1.00 1.00 C +ATOM 511 C6 C A 16 -18.278 4.466 -3.220 1.00 1.00 C +ATOM 512 H5' C A 16 -22.963 4.581 -1.650 1.00 1.00 H +ATOM 513 H5'' C A 16 -22.581 6.034 -0.705 1.00 1.00 H +ATOM 514 H4' C A 16 -21.526 3.888 0.129 1.00 1.00 H +ATOM 515 H3' C A 16 -19.830 6.288 -0.580 1.00 1.00 H +ATOM 516 H2' C A 16 -17.890 5.079 -0.237 1.00 1.00 H +ATOM 517 HO2' C A 16 -18.383 2.937 1.126 1.00 1.00 H +ATOM 518 H1' C A 16 -18.971 2.468 -0.638 1.00 1.00 H +ATOM 519 H41 C A 16 -14.698 2.944 -5.310 1.00 1.00 H +ATOM 520 H42 C A 16 -15.592 4.263 -6.047 1.00 1.00 H +ATOM 521 H5 C A 16 -17.565 5.237 -5.070 1.00 1.00 H +ATOM 522 H6 C A 16 -19.116 5.161 -3.173 1.00 1.00 H +ATOM 523 P G A 17 -19.535 6.750 2.214 1.00 1.00 P +ATOM 524 OP1 G A 17 -20.432 7.339 3.233 1.00 1.00 O +ATOM 525 OP2 G A 17 -18.804 7.631 1.276 1.00 1.00 O +ATOM 526 O5' G A 17 -18.461 5.816 2.972 1.00 1.00 O +ATOM 527 C5' G A 17 -18.869 4.951 4.037 1.00 1.00 C +ATOM 528 C4' G A 17 -17.689 4.173 4.616 1.00 1.00 C +ATOM 529 O4' G A 17 -17.067 3.403 3.587 1.00 1.00 O +ATOM 530 C3' G A 17 -16.608 5.052 5.226 1.00 1.00 C +ATOM 531 O3' G A 17 -16.833 5.194 6.631 1.00 1.00 O +ATOM 532 C2' G A 17 -15.330 4.269 4.990 1.00 1.00 C +ATOM 533 O2' G A 17 -15.019 3.425 6.101 1.00 1.00 O +ATOM 534 C1' G A 17 -15.641 3.456 3.742 1.00 1.00 C +ATOM 535 N9 G A 17 -15.087 4.039 2.517 1.00 1.00 N +ATOM 536 C8 G A 17 -15.701 4.858 1.604 1.00 1.00 C +ATOM 537 N7 G A 17 -14.931 5.222 0.618 1.00 1.00 N +ATOM 538 C5 G A 17 -13.718 4.599 0.891 1.00 1.00 C +ATOM 539 C6 G A 17 -12.496 4.628 0.165 1.00 1.00 C +ATOM 540 O6 G A 17 -12.243 5.223 -0.881 1.00 1.00 O +ATOM 541 N1 G A 17 -11.516 3.867 0.786 1.00 1.00 N +ATOM 542 C2 G A 17 -11.685 3.162 1.959 1.00 1.00 C +ATOM 543 N2 G A 17 -10.623 2.491 2.401 1.00 1.00 N +ATOM 544 N3 G A 17 -12.834 3.132 2.644 1.00 1.00 N +ATOM 545 C4 G A 17 -13.803 3.872 2.053 1.00 1.00 C +ATOM 546 H5' G A 17 -19.610 4.246 3.662 1.00 1.00 H +ATOM 547 H5'' G A 17 -19.317 5.552 4.828 1.00 1.00 H +ATOM 548 H4' G A 17 -18.059 3.490 5.379 1.00 1.00 H +ATOM 549 H3' G A 17 -16.568 6.023 4.729 1.00 1.00 H +ATOM 550 H2' G A 17 -14.508 4.957 4.785 1.00 1.00 H +ATOM 551 HO2' G A 17 -14.256 2.897 5.850 1.00 1.00 H +ATOM 552 H1' G A 17 -15.252 2.446 3.864 1.00 1.00 H +ATOM 553 H8 G A 17 -16.739 5.178 1.697 1.00 1.00 H +ATOM 554 H1 G A 17 -10.616 3.840 0.326 1.00 1.00 H +ATOM 555 H21 G A 17 -9.757 2.516 1.881 1.00 1.00 H +ATOM 556 H22 G A 17 -10.683 1.956 3.254 1.00 1.00 H +ATOM 557 P G A 18 -16.156 6.406 7.449 1.00 1.00 P +ATOM 558 OP1 G A 18 -16.534 6.272 8.873 1.00 1.00 O +ATOM 559 OP2 G A 18 -16.438 7.667 6.727 1.00 1.00 O +ATOM 560 O5' G A 18 -14.581 6.089 7.315 1.00 1.00 O +ATOM 561 C5' G A 18 -14.016 4.933 7.939 1.00 1.00 C +ATOM 562 C4' G A 18 -12.515 4.830 7.680 1.00 1.00 C +ATOM 563 O4' G A 18 -12.268 4.606 6.297 1.00 1.00 O +ATOM 564 C3' G A 18 -11.732 6.075 8.057 1.00 1.00 C +ATOM 565 O3' G A 18 -11.306 5.981 9.421 1.00 1.00 O +ATOM 566 C2' G A 18 -10.532 6.043 7.125 1.00 1.00 C +ATOM 567 O2' G A 18 -9.388 5.465 7.763 1.00 1.00 O +ATOM 568 C1' G A 18 -11.004 5.192 5.946 1.00 1.00 C +ATOM 569 N9 G A 18 -11.199 5.960 4.704 1.00 1.00 N +ATOM 570 C8 G A 18 -12.292 6.686 4.306 1.00 1.00 C +ATOM 571 N7 G A 18 -12.154 7.254 3.141 1.00 1.00 N +ATOM 572 C5 G A 18 -10.878 6.879 2.732 1.00 1.00 C +ATOM 573 C6 G A 18 -10.174 7.198 1.539 1.00 1.00 C +ATOM 574 O6 G A 18 -10.547 7.888 0.592 1.00 1.00 O +ATOM 575 N1 G A 18 -8.912 6.619 1.522 1.00 1.00 N +ATOM 576 C2 G A 18 -8.390 5.831 2.525 1.00 1.00 C +ATOM 577 N2 G A 18 -7.158 5.363 2.328 1.00 1.00 N +ATOM 578 N3 G A 18 -9.051 5.529 3.649 1.00 1.00 N +ATOM 579 C4 G A 18 -10.284 6.087 3.684 1.00 1.00 C +ATOM 580 H5' G A 18 -14.506 4.042 7.548 1.00 1.00 H +ATOM 581 H5'' G A 18 -14.187 4.990 9.014 1.00 1.00 H +ATOM 582 H4' G A 18 -12.119 3.984 8.239 1.00 1.00 H +ATOM 583 H3' G A 18 -12.330 6.973 7.890 1.00 1.00 H +ATOM 584 H2' G A 18 -10.310 7.052 6.779 1.00 1.00 H +ATOM 585 HO2' G A 18 -8.853 5.058 7.077 1.00 1.00 H +ATOM 586 H1' G A 18 -10.279 4.399 5.764 1.00 1.00 H +ATOM 587 H8 G A 18 -13.196 6.778 4.909 1.00 1.00 H +ATOM 588 H1 G A 18 -8.351 6.801 0.702 1.00 1.00 H +ATOM 589 H21 G A 18 -6.661 5.592 1.479 1.00 1.00 H +ATOM 590 H22 G A 18 -6.721 4.780 3.027 1.00 1.00 H +ATOM 591 P G A 19 -10.926 7.307 10.256 1.00 1.00 P +ATOM 592 OP1 G A 19 -10.704 6.919 11.667 1.00 1.00 O +ATOM 593 OP2 G A 19 -11.915 8.357 9.927 1.00 1.00 O +ATOM 594 O5' G A 19 -9.506 7.734 9.621 1.00 1.00 O +ATOM 595 C5' G A 19 -8.351 6.905 9.794 1.00 1.00 C +ATOM 596 C4' G A 19 -7.187 7.368 8.919 1.00 1.00 C +ATOM 597 O4' G A 19 -7.547 7.292 7.545 1.00 1.00 O +ATOM 598 C3' G A 19 -6.753 8.800 9.171 1.00 1.00 C +ATOM 599 O3' G A 19 -5.749 8.824 10.190 1.00 1.00 O +ATOM 600 C2' G A 19 -6.161 9.236 7.837 1.00 1.00 C +ATOM 601 O2' G A 19 -4.738 9.077 7.819 1.00 1.00 O +ATOM 602 C1' G A 19 -6.835 8.310 6.820 1.00 1.00 C +ATOM 603 N9 G A 19 -7.807 8.991 5.945 1.00 1.00 N +ATOM 604 C8 G A 19 -9.105 9.342 6.215 1.00 1.00 C +ATOM 605 N7 G A 19 -9.706 9.944 5.227 1.00 1.00 N +ATOM 606 C5 G A 19 -8.739 9.998 4.228 1.00 1.00 C +ATOM 607 C6 G A 19 -8.814 10.543 2.916 1.00 1.00 C +ATOM 608 O6 G A 19 -9.769 11.094 2.372 1.00 1.00 O +ATOM 609 N1 G A 19 -7.615 10.391 2.232 1.00 1.00 N +ATOM 610 C2 G A 19 -6.484 9.791 2.742 1.00 1.00 C +ATOM 611 N2 G A 19 -5.427 9.739 1.932 1.00 1.00 N +ATOM 612 N3 G A 19 -6.411 9.278 3.975 1.00 1.00 N +ATOM 613 C4 G A 19 -7.571 9.417 4.658 1.00 1.00 C +ATOM 614 H5' G A 19 -8.606 5.879 9.533 1.00 1.00 H +ATOM 615 H5'' G A 19 -8.045 6.941 10.839 1.00 1.00 H +ATOM 616 H4' G A 19 -6.337 6.710 9.087 1.00 1.00 H +ATOM 617 H3' G A 19 -7.607 9.423 9.440 1.00 1.00 H +ATOM 618 H2' G A 19 -6.436 10.273 7.632 1.00 1.00 H +ATOM 619 HO2' G A 19 -4.499 8.741 6.953 1.00 1.00 H +ATOM 620 H1' G A 19 -6.073 7.839 6.200 1.00 1.00 H +ATOM 621 H8 G A 19 -9.591 9.137 7.169 1.00 1.00 H +ATOM 622 H1 G A 19 -7.593 10.756 1.290 1.00 1.00 H +ATOM 623 H21 G A 19 -5.485 10.127 1.002 1.00 1.00 H +ATOM 624 H22 G A 19 -4.569 9.312 2.250 1.00 1.00 H +ATOM 625 P G A 20 -5.538 10.131 11.107 1.00 1.00 P +ATOM 626 OP1 G A 20 -4.507 9.824 12.124 1.00 1.00 O +ATOM 627 OP2 G A 20 -6.871 10.614 11.531 1.00 1.00 O +ATOM 628 O5' G A 20 -4.922 11.201 10.073 1.00 1.00 O +ATOM 629 C5' G A 20 -5.193 12.596 10.235 1.00 1.00 C +ATOM 630 C4' G A 20 -4.798 13.395 8.996 1.00 1.00 C +ATOM 631 O4' G A 20 -5.147 12.663 7.819 1.00 1.00 O +ATOM 632 C3' G A 20 -5.467 14.761 8.903 1.00 1.00 C +ATOM 633 O3' G A 20 -4.566 15.767 9.373 1.00 1.00 O +ATOM 634 C2' G A 20 -5.711 14.949 7.416 1.00 1.00 C +ATOM 635 O2' G A 20 -4.627 15.642 6.798 1.00 1.00 O +ATOM 636 C1' G A 20 -5.823 13.522 6.892 1.00 1.00 C +ATOM 637 N9 G A 20 -7.206 13.033 6.773 1.00 1.00 N +ATOM 638 C8 G A 20 -7.955 12.362 7.705 1.00 1.00 C +ATOM 639 N7 G A 20 -9.158 12.067 7.303 1.00 1.00 N +ATOM 640 C5 G A 20 -9.216 12.577 6.010 1.00 1.00 C +ATOM 641 C6 G A 20 -10.283 12.553 5.071 1.00 1.00 C +ATOM 642 O6 G A 20 -11.407 12.073 5.205 1.00 1.00 O +ATOM 643 N1 G A 20 -9.930 13.176 3.883 1.00 1.00 N +ATOM 644 C2 G A 20 -8.704 13.750 3.625 1.00 1.00 C +ATOM 645 N2 G A 20 -8.557 14.299 2.418 1.00 1.00 N +ATOM 646 N3 G A 20 -7.697 13.774 4.506 1.00 1.00 N +ATOM 647 C4 G A 20 -8.024 13.170 5.674 1.00 1.00 C +ATOM 648 H5' G A 20 -4.634 12.969 11.092 1.00 1.00 H +ATOM 649 H5'' G A 20 -6.258 12.731 10.422 1.00 1.00 H +ATOM 650 H4' G A 20 -3.719 13.538 9.002 1.00 1.00 H +ATOM 651 H3' G A 20 -6.406 14.779 9.458 1.00 1.00 H +ATOM 652 H2' G A 20 -6.653 15.480 7.255 1.00 1.00 H +ATOM 653 HO2' G A 20 -4.840 15.727 5.865 1.00 1.00 H +ATOM 654 H1' G A 20 -5.336 13.457 5.922 1.00 1.00 H +ATOM 655 H8 G A 20 -7.578 12.098 8.692 1.00 1.00 H +ATOM 656 H1 G A 20 -10.641 13.200 3.166 1.00 1.00 H +ATOM 657 H21 G A 20 -9.319 14.278 1.757 1.00 1.00 H +ATOM 658 H22 G A 20 -7.685 14.735 2.169 1.00 1.00 H +ATOM 659 P A A 21 -5.026 16.806 10.513 1.00 1.00 P +ATOM 660 OP1 A A 21 -3.814 17.427 11.090 1.00 1.00 O +ATOM 661 OP2 A A 21 -5.998 16.123 11.396 1.00 1.00 O +ATOM 662 O5' A A 21 -5.814 17.927 9.669 1.00 1.00 O +ATOM 663 C5' A A 21 -6.940 18.607 10.233 1.00 1.00 C +ATOM 664 C4' A A 21 -7.353 19.802 9.378 1.00 1.00 C +ATOM 665 O4' A A 21 -6.341 20.812 9.452 1.00 1.00 O +ATOM 666 C3' A A 21 -7.559 19.453 7.906 1.00 1.00 C +ATOM 667 O3' A A 21 -8.958 19.445 7.604 1.00 1.00 O +ATOM 668 C2' A A 21 -6.885 20.585 7.146 1.00 1.00 C +ATOM 669 O2' A A 21 -7.827 21.587 6.752 1.00 1.00 O +ATOM 670 C1' A A 21 -5.877 21.137 8.137 1.00 1.00 C +ATOM 671 N9 A A 21 -4.528 20.568 7.983 1.00 1.00 N +ATOM 672 C8 A A 21 -3.906 19.629 8.766 1.00 1.00 C +ATOM 673 N7 A A 21 -2.705 19.319 8.362 1.00 1.00 N +ATOM 674 C5 A A 21 -2.519 20.110 7.233 1.00 1.00 C +ATOM 675 C6 A A 21 -1.445 20.252 6.338 1.00 1.00 C +ATOM 676 N6 A A 21 -0.306 19.568 6.448 1.00 1.00 N +ATOM 677 N1 A A 21 -1.596 21.127 5.329 1.00 1.00 N +ATOM 678 C2 A A 21 -2.732 21.803 5.222 1.00 1.00 C +ATOM 679 N3 A A 21 -3.807 21.758 5.994 1.00 1.00 N +ATOM 680 C4 A A 21 -3.626 20.874 6.996 1.00 1.00 C +ATOM 681 H5' A A 21 -6.682 18.956 11.232 1.00 1.00 H +ATOM 682 H5'' A A 21 -7.776 17.912 10.302 1.00 1.00 H +ATOM 683 H4' A A 21 -8.280 20.212 9.774 1.00 1.00 H +ATOM 684 H3' A A 21 -7.098 18.494 7.664 1.00 1.00 H +ATOM 685 H2' A A 21 -6.363 20.184 6.274 1.00 1.00 H +ATOM 686 HO2' A A 21 -7.353 22.422 6.712 1.00 1.00 H +ATOM 687 H1' A A 21 -5.822 22.220 8.031 1.00 1.00 H +ATOM 688 H8 A A 21 -4.374 19.182 9.643 1.00 1.00 H +ATOM 689 H61 A A 21 0.435 19.708 5.778 1.00 1.00 H +ATOM 690 H62 A A 21 -0.185 18.908 7.204 1.00 1.00 H +ATOM 691 H2 A A 21 -2.787 22.495 4.382 1.00 1.00 H +ATOM 692 P A A 22 -9.540 18.476 6.457 1.00 1.00 P +ATOM 693 OP1 A A 22 -11.003 18.682 6.372 1.00 1.00 O +ATOM 694 OP2 A A 22 -8.998 17.117 6.683 1.00 1.00 O +ATOM 695 O5' A A 22 -8.867 19.073 5.122 1.00 1.00 O +ATOM 696 C5' A A 22 -9.179 20.397 4.684 1.00 1.00 C +ATOM 697 C4' A A 22 -8.038 20.995 3.867 1.00 1.00 C +ATOM 698 O4' A A 22 -6.808 20.779 4.555 1.00 1.00 O +ATOM 699 C3' A A 22 -7.893 20.397 2.474 1.00 1.00 C +ATOM 700 O3' A A 22 -8.514 21.267 1.522 1.00 1.00 O +ATOM 701 C2' A A 22 -6.389 20.358 2.235 1.00 1.00 C +ATOM 702 O2' A A 22 -5.945 21.502 1.498 1.00 1.00 O +ATOM 703 C1' A A 22 -5.800 20.337 3.643 1.00 1.00 C +ATOM 704 N9 A A 22 -5.362 19.001 4.074 1.00 1.00 N +ATOM 705 C8 A A 22 -6.036 18.071 4.822 1.00 1.00 C +ATOM 706 N7 A A 22 -5.356 16.979 5.046 1.00 1.00 N +ATOM 707 C5 A A 22 -4.145 17.204 4.398 1.00 1.00 C +ATOM 708 C6 A A 22 -2.985 16.424 4.259 1.00 1.00 C +ATOM 709 N6 A A 22 -2.856 15.207 4.787 1.00 1.00 N +ATOM 710 N1 A A 22 -1.970 16.951 3.553 1.00 1.00 N +ATOM 711 C2 A A 22 -2.106 18.163 3.029 1.00 1.00 C +ATOM 712 N3 A A 22 -3.138 18.989 3.090 1.00 1.00 N +ATOM 713 C4 A A 22 -4.141 18.434 3.804 1.00 1.00 C +ATOM 714 H5' A A 22 -9.363 21.027 5.553 1.00 1.00 H +ATOM 715 H5'' A A 22 -10.079 20.366 4.069 1.00 1.00 H +ATOM 716 H4' A A 22 -8.195 22.067 3.775 1.00 1.00 H +ATOM 717 H3' A A 22 -8.320 19.395 2.434 1.00 1.00 H +ATOM 718 H2' A A 22 -6.124 19.437 1.711 1.00 1.00 H +ATOM 719 HO2' A A 22 -6.612 22.185 1.601 1.00 1.00 H +ATOM 720 H1' A A 22 -4.952 21.017 3.698 1.00 1.00 H +ATOM 721 H8 A A 22 -7.049 18.227 5.195 1.00 1.00 H +ATOM 722 H61 A A 22 -2.000 14.688 4.655 1.00 1.00 H +ATOM 723 H62 A A 22 -3.615 14.805 5.318 1.00 1.00 H +ATOM 724 H2 A A 22 -1.246 18.530 2.468 1.00 1.00 H +ATOM 725 P A A 23 -9.045 20.696 0.115 1.00 1.00 P +ATOM 726 OP1 A A 23 -9.799 21.772 -0.566 1.00 1.00 O +ATOM 727 OP2 A A 23 -9.688 19.385 0.360 1.00 1.00 O +ATOM 728 O5' A A 23 -7.677 20.443 -0.699 1.00 1.00 O +ATOM 729 C5' A A 23 -7.558 19.334 -1.591 1.00 1.00 C +ATOM 730 C4' A A 23 -6.098 19.031 -1.916 1.00 1.00 C +ATOM 731 O4' A A 23 -5.341 18.965 -0.705 1.00 1.00 O +ATOM 732 C3' A A 23 -5.889 17.713 -2.651 1.00 1.00 C +ATOM 733 O3' A A 23 -5.801 17.954 -4.060 1.00 1.00 O +ATOM 734 C2' A A 23 -4.548 17.219 -2.132 1.00 1.00 C +ATOM 735 O2' A A 23 -3.471 17.661 -2.963 1.00 1.00 O +ATOM 736 C1' A A 23 -4.463 17.830 -0.740 1.00 1.00 C +ATOM 737 N9 A A 23 -4.880 16.910 0.333 1.00 1.00 N +ATOM 738 C8 A A 23 -6.130 16.734 0.871 1.00 1.00 C +ATOM 739 N7 A A 23 -6.179 15.818 1.800 1.00 1.00 N +ATOM 740 C5 A A 23 -4.869 15.356 1.882 1.00 1.00 C +ATOM 741 C6 A A 23 -4.254 14.376 2.681 1.00 1.00 C +ATOM 742 N6 A A 23 -4.911 13.652 3.587 1.00 1.00 N +ATOM 743 N1 A A 23 -2.938 14.175 2.503 1.00 1.00 N +ATOM 744 C2 A A 23 -2.288 14.896 1.598 1.00 1.00 C +ATOM 745 N3 A A 23 -2.751 15.838 0.791 1.00 1.00 N +ATOM 746 C4 A A 23 -4.073 16.017 0.992 1.00 1.00 C +ATOM 747 H5' A A 23 -8.089 19.561 -2.516 1.00 1.00 H +ATOM 748 H5'' A A 23 -8.010 18.456 -1.129 1.00 1.00 H +ATOM 749 H4' A A 23 -5.699 19.838 -2.527 1.00 1.00 H +ATOM 750 H3' A A 23 -6.685 17.004 -2.418 1.00 1.00 H +ATOM 751 H2' A A 23 -4.554 16.130 -2.055 1.00 1.00 H +ATOM 752 HO2' A A 23 -2.804 16.969 -2.956 1.00 1.00 H +ATOM 753 H1' A A 23 -3.442 18.158 -0.552 1.00 1.00 H +ATOM 754 H8 A A 23 -7.001 17.306 0.552 1.00 1.00 H +ATOM 755 H61 A A 23 -4.418 12.961 4.134 1.00 1.00 H +ATOM 756 H62 A A 23 -5.907 13.795 3.730 1.00 1.00 H +ATOM 757 H2 A A 23 -1.224 14.681 1.507 1.00 1.00 H +ATOM 758 P C A 24 -6.531 16.970 -5.104 1.00 1.00 P +ATOM 759 OP1 C A 24 -6.217 17.430 -6.476 1.00 1.00 O +ATOM 760 OP2 C A 24 -7.943 16.814 -4.684 1.00 1.00 O +ATOM 761 O5' C A 24 -5.774 15.571 -4.856 1.00 1.00 O +ATOM 762 C5' C A 24 -4.354 15.479 -4.993 1.00 1.00 C +ATOM 763 C4' C A 24 -3.773 14.387 -4.099 1.00 1.00 C +ATOM 764 O4' C A 24 -4.212 14.575 -2.755 1.00 1.00 O +ATOM 765 C3' C A 24 -4.182 12.977 -4.489 1.00 1.00 C +ATOM 766 O3' C A 24 -3.228 12.433 -5.406 1.00 1.00 O +ATOM 767 C2' C A 24 -4.130 12.214 -3.176 1.00 1.00 C +ATOM 768 O2' C A 24 -2.857 11.586 -2.986 1.00 1.00 O +ATOM 769 C1' C A 24 -4.377 13.293 -2.125 1.00 1.00 C +ATOM 770 N1 C A 24 -5.731 13.251 -1.542 1.00 1.00 N +ATOM 771 C2 C A 24 -5.940 12.393 -0.474 1.00 1.00 C +ATOM 772 O2 C A 24 -5.015 11.702 -0.049 1.00 1.00 O +ATOM 773 N3 C A 24 -7.184 12.342 0.079 1.00 1.00 N +ATOM 774 C4 C A 24 -8.180 13.100 -0.399 1.00 1.00 C +ATOM 775 N4 C A 24 -9.386 13.026 0.166 1.00 1.00 N +ATOM 776 C5 C A 24 -7.968 13.986 -1.501 1.00 1.00 C +ATOM 777 C6 C A 24 -6.734 14.030 -2.039 1.00 1.00 C +ATOM 778 H5' C A 24 -3.908 16.436 -4.723 1.00 1.00 H +ATOM 779 H5'' C A 24 -4.112 15.254 -6.033 1.00 1.00 H +ATOM 780 H4' C A 24 -2.688 14.457 -4.117 1.00 1.00 H +ATOM 781 H3' C A 24 -5.190 12.964 -4.907 1.00 1.00 H +ATOM 782 H2' C A 24 -4.933 11.476 -3.143 1.00 1.00 H +ATOM 783 HO2' C A 24 -2.958 10.950 -2.274 1.00 1.00 H +ATOM 784 H1' C A 24 -3.643 13.191 -1.328 1.00 1.00 H +ATOM 785 H41 C A 24 -9.542 12.402 0.944 1.00 1.00 H +ATOM 786 H42 C A 24 -10.144 13.594 -0.187 1.00 1.00 H +ATOM 787 H5 C A 24 -8.775 14.604 -1.892 1.00 1.00 H +ATOM 788 H6 C A 24 -6.534 14.693 -2.881 1.00 1.00 H +ATOM 789 P U A 25 -3.630 11.213 -6.378 1.00 1.00 P +ATOM 790 OP1 U A 25 -2.478 10.921 -7.259 1.00 1.00 O +ATOM 791 OP2 U A 25 -4.955 11.508 -6.968 1.00 1.00 O +ATOM 792 O5' U A 25 -3.803 9.987 -5.348 1.00 1.00 O +ATOM 793 C5' U A 25 -2.694 9.538 -4.563 1.00 1.00 C +ATOM 794 C4' U A 25 -3.126 8.509 -3.522 1.00 1.00 C +ATOM 795 O4' U A 25 -4.069 9.088 -2.624 1.00 1.00 O +ATOM 796 C3' U A 25 -3.795 7.276 -4.100 1.00 1.00 C +ATOM 797 O3' U A 25 -2.808 6.277 -4.381 1.00 1.00 O +ATOM 798 C2' U A 25 -4.697 6.800 -2.975 1.00 1.00 C +ATOM 799 O2' U A 25 -4.057 5.795 -2.193 1.00 1.00 O +ATOM 800 C1' U A 25 -4.951 8.060 -2.147 1.00 1.00 C +ATOM 801 N1 U A 25 -6.334 8.570 -2.250 1.00 1.00 N +ATOM 802 C2 U A 25 -7.234 8.200 -1.268 1.00 1.00 C +ATOM 803 O2 U A 25 -6.916 7.470 -0.331 1.00 1.00 O +ATOM 804 N3 U A 25 -8.517 8.699 -1.401 1.00 1.00 N +ATOM 805 C4 U A 25 -8.972 9.524 -2.415 1.00 1.00 C +ATOM 806 O4 U A 25 -10.139 9.910 -2.434 1.00 1.00 O +ATOM 807 C5 U A 25 -7.964 9.860 -3.396 1.00 1.00 C +ATOM 808 C6 U A 25 -6.700 9.383 -3.288 1.00 1.00 C +ATOM 809 H5' U A 25 -2.248 10.391 -4.054 1.00 1.00 H +ATOM 810 H5'' U A 25 -1.952 9.086 -5.220 1.00 1.00 H +ATOM 811 H4' U A 25 -2.256 8.200 -2.948 1.00 1.00 H +ATOM 812 H3' U A 25 -4.374 7.526 -4.990 1.00 1.00 H +ATOM 813 H2' U A 25 -5.637 6.426 -3.386 1.00 1.00 H +ATOM 814 HO2' U A 25 -4.516 5.759 -1.350 1.00 1.00 H +ATOM 815 H1' U A 25 -4.718 7.851 -1.102 1.00 1.00 H +ATOM 816 H3 U A 25 -9.186 8.437 -0.692 1.00 1.00 H +ATOM 817 H5 U A 25 -8.225 10.505 -4.236 1.00 1.00 H +ATOM 818 H6 U A 25 -5.961 9.652 -4.042 1.00 1.00 H +ATOM 819 P U A 26 -3.205 4.946 -5.196 1.00 1.00 P +ATOM 820 OP1 U A 26 -1.958 4.256 -5.595 1.00 1.00 O +ATOM 821 OP2 U A 26 -4.206 5.315 -6.222 1.00 1.00 O +ATOM 822 O5' U A 26 -3.940 4.051 -4.075 1.00 1.00 O +ATOM 823 C5' U A 26 -3.199 3.498 -2.983 1.00 1.00 C +ATOM 824 C4' U A 26 -4.121 2.903 -1.923 1.00 1.00 C +ATOM 825 O4' U A 26 -5.036 3.896 -1.458 1.00 1.00 O +ATOM 826 C3' U A 26 -4.966 1.744 -2.416 1.00 1.00 C +ATOM 827 O3' U A 26 -4.266 0.505 -2.223 1.00 1.00 O +ATOM 828 C2' U A 26 -6.190 1.806 -1.516 1.00 1.00 C +ATOM 829 O2' U A 26 -6.029 0.998 -0.351 1.00 1.00 O +ATOM 830 C1' U A 26 -6.293 3.276 -1.142 1.00 1.00 C +ATOM 831 N1 U A 26 -7.355 3.992 -1.881 1.00 1.00 N +ATOM 832 C2 U A 26 -8.562 4.211 -1.243 1.00 1.00 C +ATOM 833 O2 U A 26 -8.772 3.832 -0.093 1.00 1.00 O +ATOM 834 N3 U A 26 -9.524 4.882 -1.976 1.00 1.00 N +ATOM 835 C4 U A 26 -9.386 5.346 -3.274 1.00 1.00 C +ATOM 836 O4 U A 26 -10.310 5.933 -3.831 1.00 1.00 O +ATOM 837 C5 U A 26 -8.093 5.073 -3.862 1.00 1.00 C +ATOM 838 C6 U A 26 -7.135 4.418 -3.162 1.00 1.00 C +ATOM 839 H5' U A 26 -2.595 4.282 -2.527 1.00 1.00 H +ATOM 840 H5'' U A 26 -2.541 2.715 -3.361 1.00 1.00 H +ATOM 841 H4' U A 26 -3.522 2.567 -1.080 1.00 1.00 H +ATOM 842 H3' U A 26 -5.245 1.884 -3.462 1.00 1.00 H +ATOM 843 H2' U A 26 -7.074 1.515 -2.079 1.00 1.00 H +ATOM 844 HO2' U A 26 -5.885 1.591 0.389 1.00 1.00 H +ATOM 845 H1' U A 26 -6.473 3.360 -0.069 1.00 1.00 H +ATOM 846 H3 U A 26 -10.412 5.049 -1.523 1.00 1.00 H +ATOM 847 H5 U A 26 -7.887 5.396 -4.882 1.00 1.00 H +ATOM 848 H6 U A 26 -6.169 4.227 -3.630 1.00 1.00 H +ATOM 849 P G A 27 -4.722 -0.829 -3.013 1.00 1.00 P +ATOM 850 OP1 G A 27 -3.736 -1.900 -2.737 1.00 1.00 O +ATOM 851 OP2 G A 27 -5.036 -0.458 -4.411 1.00 1.00 O +ATOM 852 O5' G A 27 -6.099 -1.207 -2.273 1.00 1.00 O +ATOM 853 C5' G A 27 -6.110 -1.445 -0.865 1.00 1.00 C +ATOM 854 C4' G A 27 -7.500 -1.236 -0.272 1.00 1.00 C +ATOM 855 O4' G A 27 -8.037 0.006 -0.728 1.00 1.00 O +ATOM 856 C3' G A 27 -8.519 -2.295 -0.653 1.00 1.00 C +ATOM 857 O3' G A 27 -8.501 -3.340 0.328 1.00 1.00 O +ATOM 858 C2' G A 27 -9.845 -1.554 -0.574 1.00 1.00 C +ATOM 859 O2' G A 27 -10.501 -1.803 0.676 1.00 1.00 O +ATOM 860 C1' G A 27 -9.465 -0.083 -0.723 1.00 1.00 C +ATOM 861 N9 G A 27 -10.015 0.555 -1.935 1.00 1.00 N +ATOM 862 C8 G A 27 -9.454 0.728 -3.175 1.00 1.00 C +ATOM 863 N7 G A 27 -10.219 1.367 -4.016 1.00 1.00 N +ATOM 864 C5 G A 27 -11.370 1.637 -3.283 1.00 1.00 C +ATOM 865 C6 G A 27 -12.561 2.313 -3.668 1.00 1.00 C +ATOM 866 O6 G A 27 -12.833 2.821 -4.754 1.00 1.00 O +ATOM 867 N1 G A 27 -13.478 2.366 -2.626 1.00 1.00 N +ATOM 868 C2 G A 27 -13.276 1.836 -1.369 1.00 1.00 C +ATOM 869 N2 G A 27 -14.275 1.981 -0.501 1.00 1.00 N +ATOM 870 N3 G A 27 -12.158 1.203 -1.004 1.00 1.00 N +ATOM 871 C4 G A 27 -11.254 1.142 -2.009 1.00 1.00 C +ATOM 872 H5' G A 27 -5.409 -0.767 -0.380 1.00 1.00 H +ATOM 873 H5'' G A 27 -5.796 -2.473 -0.679 1.00 1.00 H +ATOM 874 H4' G A 27 -7.423 -1.199 0.812 1.00 1.00 H +ATOM 875 H3' G A 27 -8.337 -2.681 -1.657 1.00 1.00 H +ATOM 876 H2' G A 27 -10.485 -1.855 -1.407 1.00 1.00 H +ATOM 877 HO2' G A 27 -10.358 -1.039 1.236 1.00 1.00 H +ATOM 878 H1' G A 27 -9.833 0.466 0.143 1.00 1.00 H +ATOM 879 H8 G A 27 -8.463 0.359 -3.437 1.00 1.00 H +ATOM 880 H1 G A 27 -14.349 2.834 -2.824 1.00 1.00 H +ATOM 881 H21 G A 27 -15.124 2.459 -0.778 1.00 1.00 H +ATOM 882 H22 G A 27 -14.186 1.612 0.435 1.00 1.00 H +ATOM 883 P G A 28 -9.286 -4.722 0.073 1.00 1.00 P +ATOM 884 OP1 G A 28 -8.649 -5.774 0.899 1.00 1.00 O +ATOM 885 OP2 G A 28 -9.421 -4.913 -1.387 1.00 1.00 O +ATOM 886 O5' G A 28 -10.749 -4.425 0.682 1.00 1.00 O +ATOM 887 C5' G A 28 -10.987 -4.497 2.092 1.00 1.00 C +ATOM 888 C4' G A 28 -12.472 -4.676 2.398 1.00 1.00 C +ATOM 889 O4' G A 28 -13.133 -3.406 2.378 1.00 1.00 O +ATOM 890 C3' G A 28 -13.192 -5.577 1.403 1.00 1.00 C +ATOM 891 O3' G A 28 -13.278 -6.904 1.932 1.00 1.00 O +ATOM 892 C2' G A 28 -14.576 -4.964 1.292 1.00 1.00 C +ATOM 893 O2' G A 28 -15.484 -5.537 2.236 1.00 1.00 O +ATOM 894 C1' G A 28 -14.325 -3.494 1.583 1.00 1.00 C +ATOM 895 N9 G A 28 -14.095 -2.692 0.378 1.00 1.00 N +ATOM 896 C8 G A 28 -12.895 -2.311 -0.165 1.00 1.00 C +ATOM 897 N7 G A 28 -13.006 -1.608 -1.256 1.00 1.00 N +ATOM 898 C5 G A 28 -14.381 -1.512 -1.454 1.00 1.00 C +ATOM 899 C6 G A 28 -15.107 -0.860 -2.489 1.00 1.00 C +ATOM 900 O6 G A 28 -14.669 -0.232 -3.450 1.00 1.00 O +ATOM 901 N1 G A 28 -16.477 -1.004 -2.316 1.00 1.00 N +ATOM 902 C2 G A 28 -17.077 -1.688 -1.280 1.00 1.00 C +ATOM 903 N2 G A 28 -18.408 -1.716 -1.287 1.00 1.00 N +ATOM 904 N3 G A 28 -16.396 -2.301 -0.306 1.00 1.00 N +ATOM 905 C4 G A 28 -15.056 -2.172 -0.458 1.00 1.00 C +ATOM 906 H5' G A 28 -10.636 -3.577 2.561 1.00 1.00 H +ATOM 907 H5'' G A 28 -10.436 -5.341 2.504 1.00 1.00 H +ATOM 908 H4' G A 28 -12.575 -5.102 3.395 1.00 1.00 H +ATOM 909 H3' G A 28 -12.683 -5.566 0.437 1.00 1.00 H +ATOM 910 H2' G A 28 -14.951 -5.078 0.275 1.00 1.00 H +ATOM 911 HO2' G A 28 -15.216 -5.232 3.106 1.00 1.00 H +ATOM 912 H1' G A 28 -15.167 -3.082 2.136 1.00 1.00 H +ATOM 913 H8 G A 28 -11.933 -2.570 0.279 1.00 1.00 H +ATOM 914 H1 G A 28 -17.061 -0.566 -3.015 1.00 1.00 H +ATOM 915 H21 G A 28 -18.921 -1.249 -2.030 1.00 1.00 H +ATOM 916 H22 G A 28 -18.907 -2.201 -0.556 1.00 1.00 H +ATOM 917 P U A 29 -13.358 -8.177 0.947 1.00 1.00 P +ATOM 918 OP1 U A 29 -13.224 -9.403 1.764 1.00 1.00 O +ATOM 919 OP2 U A 29 -12.435 -7.943 -0.187 1.00 1.00 O +ATOM 920 O5' U A 29 -14.867 -8.109 0.387 1.00 1.00 O +ATOM 921 C5' U A 29 -15.967 -8.508 1.210 1.00 1.00 C +ATOM 922 C4' U A 29 -17.296 -8.378 0.472 1.00 1.00 C +ATOM 923 O4' U A 29 -17.506 -7.015 0.110 1.00 1.00 O +ATOM 924 C3' U A 29 -17.375 -9.188 -0.809 1.00 1.00 C +ATOM 925 O3' U A 29 -17.948 -10.471 -0.530 1.00 1.00 O +ATOM 926 C2' U A 29 -18.318 -8.372 -1.683 1.00 1.00 C +ATOM 927 O2' U A 29 -19.680 -8.777 -1.503 1.00 1.00 O +ATOM 928 C1' U A 29 -18.094 -6.941 -1.199 1.00 1.00 C +ATOM 929 N1 U A 29 -17.165 -6.166 -2.049 1.00 1.00 N +ATOM 930 C2 U A 29 -17.702 -5.378 -3.051 1.00 1.00 C +ATOM 931 O2 U A 29 -18.913 -5.307 -3.247 1.00 1.00 O +ATOM 932 N3 U A 29 -16.796 -4.672 -3.820 1.00 1.00 N +ATOM 933 C4 U A 29 -15.417 -4.687 -3.679 1.00 1.00 C +ATOM 934 O4 U A 29 -14.704 -4.017 -4.423 1.00 1.00 O +ATOM 935 C5 U A 29 -14.945 -5.535 -2.608 1.00 1.00 C +ATOM 936 C6 U A 29 -15.814 -6.236 -1.840 1.00 1.00 C +ATOM 937 H5' U A 29 -15.994 -7.880 2.100 1.00 1.00 H +ATOM 938 H5'' U A 29 -15.827 -9.546 1.511 1.00 1.00 H +ATOM 939 H4' U A 29 -18.102 -8.687 1.136 1.00 1.00 H +ATOM 940 H3' U A 29 -16.392 -9.282 -1.274 1.00 1.00 H +ATOM 941 H2' U A 29 -18.025 -8.456 -2.729 1.00 1.00 H +ATOM 942 HO2' U A 29 -20.174 -8.001 -1.227 1.00 1.00 H +ATOM 943 H1' U A 29 -19.053 -6.425 -1.135 1.00 1.00 H +ATOM 944 H3 U A 29 -17.173 -4.093 -4.556 1.00 1.00 H +ATOM 945 H5 U A 29 -13.875 -5.614 -2.416 1.00 1.00 H +ATOM 946 H6 U A 29 -15.430 -6.870 -1.041 1.00 1.00 H +ATOM 947 P U A 30 -17.403 -11.790 -1.277 1.00 1.00 P +ATOM 948 OP1 U A 30 -18.144 -12.959 -0.753 1.00 1.00 O +ATOM 949 OP2 U A 30 -15.925 -11.770 -1.228 1.00 1.00 O +ATOM 950 O5' U A 30 -17.858 -11.546 -2.803 1.00 1.00 O +ATOM 951 C5' U A 30 -19.201 -11.816 -3.218 1.00 1.00 C +ATOM 952 C4' U A 30 -19.398 -11.515 -4.700 1.00 1.00 C +ATOM 953 O4' U A 30 -19.244 -10.117 -4.940 1.00 1.00 O +ATOM 954 C3' U A 30 -18.405 -12.217 -5.609 1.00 1.00 C +ATOM 955 O3' U A 30 -18.911 -13.502 -5.994 1.00 1.00 O +ATOM 956 C2' U A 30 -18.334 -11.295 -6.816 1.00 1.00 C +ATOM 957 O2' U A 30 -19.310 -11.644 -7.802 1.00 1.00 O +ATOM 958 C1' U A 30 -18.611 -9.918 -6.217 1.00 1.00 C +ATOM 959 N1 U A 30 -17.391 -9.124 -5.985 1.00 1.00 N +ATOM 960 C2 U A 30 -16.988 -8.249 -6.976 1.00 1.00 C +ATOM 961 O2 U A 30 -17.612 -8.121 -8.027 1.00 1.00 O +ATOM 962 N3 U A 30 -15.840 -7.523 -6.716 1.00 1.00 N +ATOM 963 C4 U A 30 -15.070 -7.596 -5.568 1.00 1.00 C +ATOM 964 O4 U A 30 -14.064 -6.901 -5.442 1.00 1.00 O +ATOM 965 C5 U A 30 -15.564 -8.536 -4.586 1.00 1.00 C +ATOM 966 C6 U A 30 -16.688 -9.257 -4.818 1.00 1.00 C +ATOM 967 H5' U A 30 -19.884 -11.197 -2.636 1.00 1.00 H +ATOM 968 H5'' U A 30 -19.426 -12.866 -3.033 1.00 1.00 H +ATOM 969 H4' U A 30 -20.406 -11.805 -4.988 1.00 1.00 H +ATOM 970 H3' U A 30 -17.430 -12.303 -5.127 1.00 1.00 H +ATOM 971 H2' U A 30 -17.331 -11.317 -7.240 1.00 1.00 H +ATOM 972 HO2' U A 30 -20.018 -10.997 -7.742 1.00 1.00 H +ATOM 973 H1' U A 30 -19.286 -9.364 -6.872 1.00 1.00 H +ATOM 974 H3 U A 30 -15.533 -6.879 -7.432 1.00 1.00 H +ATOM 975 H5 U A 30 -15.026 -8.665 -3.648 1.00 1.00 H +ATOM 976 H6 U A 30 -17.039 -9.958 -4.060 1.00 1.00 H +ATOM 977 P C A 31 -17.898 -14.702 -6.358 1.00 1.00 P +ATOM 978 OP1 C A 31 -18.699 -15.906 -6.674 1.00 1.00 O +ATOM 979 OP2 C A 31 -16.858 -14.765 -5.306 1.00 1.00 O +ATOM 980 O5' C A 31 -17.206 -14.184 -7.718 1.00 1.00 O +ATOM 981 C5' C A 31 -17.945 -14.147 -8.943 1.00 1.00 C +ATOM 982 C4' C A 31 -17.238 -13.304 -9.999 1.00 1.00 C +ATOM 983 O4' C A 31 -16.988 -11.994 -9.496 1.00 1.00 O +ATOM 984 C3' C A 31 -15.893 -13.843 -10.431 1.00 1.00 C +ATOM 985 O3' C A 31 -16.068 -14.803 -11.482 1.00 1.00 O +ATOM 986 C2' C A 31 -15.185 -12.600 -10.953 1.00 1.00 C +ATOM 987 O2' C A 31 -15.345 -12.461 -12.370 1.00 1.00 O +ATOM 988 C1' C A 31 -15.850 -11.451 -10.189 1.00 1.00 C +ATOM 989 N1 C A 31 -14.963 -10.818 -9.187 1.00 1.00 N +ATOM 990 C2 C A 31 -14.292 -9.663 -9.558 1.00 1.00 C +ATOM 991 O2 C A 31 -14.440 -9.202 -10.687 1.00 1.00 O +ATOM 992 N3 C A 31 -13.478 -9.068 -8.643 1.00 1.00 N +ATOM 993 C4 C A 31 -13.327 -9.584 -7.417 1.00 1.00 C +ATOM 994 N4 C A 31 -12.522 -8.974 -6.546 1.00 1.00 N +ATOM 995 C5 C A 31 -14.017 -10.776 -7.029 1.00 1.00 C +ATOM 996 C6 C A 31 -14.821 -11.358 -7.941 1.00 1.00 C +ATOM 997 H5' C A 31 -18.928 -13.724 -8.753 1.00 1.00 H +ATOM 998 H5'' C A 31 -18.059 -15.163 -9.319 1.00 1.00 H +ATOM 999 H4' C A 31 -17.879 -13.218 -10.873 1.00 1.00 H +ATOM 1000 H3' C A 31 -15.355 -14.274 -9.584 1.00 1.00 H +ATOM 1001 H2' C A 31 -14.136 -12.644 -10.690 1.00 1.00 H +ATOM 1002 HO2' C A 31 -16.030 -11.807 -12.520 1.00 1.00 H +ATOM 1003 H1' C A 31 -16.193 -10.691 -10.895 1.00 1.00 H +ATOM 1004 H41 C A 31 -12.034 -8.136 -6.812 1.00 1.00 H +ATOM 1005 H42 C A 31 -12.400 -9.355 -5.620 1.00 1.00 H +ATOM 1006 H5 C A 31 -13.897 -11.198 -6.031 1.00 1.00 H +ATOM 1007 H6 C A 31 -15.363 -12.268 -7.680 1.00 1.00 H +ATOM 1008 P U A 32 -15.253 -16.195 -11.465 1.00 1.00 P +ATOM 1009 OP1 U A 32 -16.058 -17.219 -12.170 1.00 1.00 O +ATOM 1010 OP2 U A 32 -14.794 -16.444 -10.081 1.00 1.00 O +ATOM 1011 O5' U A 32 -13.959 -15.862 -12.363 1.00 1.00 O +ATOM 1012 C5' U A 32 -14.110 -15.319 -13.675 1.00 1.00 C +ATOM 1013 C4' U A 32 -13.081 -14.221 -13.950 1.00 1.00 C +ATOM 1014 O4' U A 32 -13.103 -13.237 -12.918 1.00 1.00 O +ATOM 1015 C3' U A 32 -11.647 -14.711 -14.023 1.00 1.00 C +ATOM 1016 O3' U A 32 -11.342 -15.106 -15.366 1.00 1.00 O +ATOM 1017 C2' U A 32 -10.834 -13.478 -13.656 1.00 1.00 C +ATOM 1018 O2' U A 32 -10.335 -12.812 -14.817 1.00 1.00 O +ATOM 1019 C1' U A 32 -11.813 -12.598 -12.885 1.00 1.00 C +ATOM 1020 N1 U A 32 -11.419 -12.351 -11.477 1.00 1.00 N +ATOM 1021 C2 U A 32 -10.701 -11.200 -11.217 1.00 1.00 C +ATOM 1022 O2 U A 32 -10.384 -10.412 -12.107 1.00 1.00 O +ATOM 1023 N3 U A 32 -10.355 -10.985 -9.895 1.00 1.00 N +ATOM 1024 C4 U A 32 -10.662 -11.810 -8.827 1.00 1.00 C +ATOM 1025 O4 U A 32 -10.304 -11.519 -7.687 1.00 1.00 O +ATOM 1026 C5 U A 32 -11.413 -12.991 -9.190 1.00 1.00 C +ATOM 1027 C6 U A 32 -11.763 -13.222 -10.479 1.00 1.00 C +ATOM 1028 H5' U A 32 -15.111 -14.903 -13.777 1.00 1.00 H +ATOM 1029 H5'' U A 32 -13.981 -16.117 -14.407 1.00 1.00 H +ATOM 1030 H4' U A 32 -13.332 -13.733 -14.887 1.00 1.00 H +ATOM 1031 H3' U A 32 -11.471 -15.524 -13.316 1.00 1.00 H +ATOM 1032 H2' U A 32 -10.014 -13.768 -12.999 1.00 1.00 H +ATOM 1033 HO2' U A 32 -9.382 -12.944 -14.826 1.00 1.00 H +ATOM 1034 H1' U A 32 -11.898 -11.640 -13.399 1.00 1.00 H +ATOM 1035 H3 U A 32 -9.830 -10.146 -9.690 1.00 1.00 H +ATOM 1036 H5 U A 32 -11.700 -13.705 -8.418 1.00 1.00 H +ATOM 1037 H6 U A 32 -12.329 -14.120 -10.725 1.00 1.00 H +ATOM 1038 P U A 33 -10.108 -16.097 -15.673 1.00 1.00 P +ATOM 1039 OP1 U A 33 -10.284 -16.646 -17.036 1.00 1.00 O +ATOM 1040 OP2 U A 33 -9.959 -17.017 -14.522 1.00 1.00 O +ATOM 1041 O5' U A 33 -8.839 -15.103 -15.692 1.00 1.00 O +ATOM 1042 C5' U A 33 -8.659 -14.168 -16.761 1.00 1.00 C +ATOM 1043 C4' U A 33 -7.507 -13.206 -16.479 1.00 1.00 C +ATOM 1044 O4' U A 33 -7.771 -12.485 -15.280 1.00 1.00 O +ATOM 1045 C3' U A 33 -6.160 -13.886 -16.290 1.00 1.00 C +ATOM 1046 O3' U A 33 -5.468 -13.934 -17.542 1.00 1.00 O +ATOM 1047 C2' U A 33 -5.421 -12.970 -15.324 1.00 1.00 C +ATOM 1048 O2' U A 33 -4.573 -12.052 -16.023 1.00 1.00 O +ATOM 1049 C1' U A 33 -6.541 -12.237 -14.583 1.00 1.00 C +ATOM 1050 N1 U A 33 -6.728 -12.693 -13.189 1.00 1.00 N +ATOM 1051 C2 U A 33 -6.120 -11.963 -12.185 1.00 1.00 C +ATOM 1052 O2 U A 33 -5.444 -10.964 -12.420 1.00 1.00 O +ATOM 1053 N3 U A 33 -6.316 -12.423 -10.895 1.00 1.00 N +ATOM 1054 C4 U A 33 -7.057 -13.534 -10.527 1.00 1.00 C +ATOM 1055 O4 U A 33 -7.164 -13.853 -9.345 1.00 1.00 O +ATOM 1056 C5 U A 33 -7.656 -14.235 -11.641 1.00 1.00 C +ATOM 1057 C6 U A 33 -7.479 -13.803 -12.913 1.00 1.00 C +ATOM 1058 H5' U A 33 -9.575 -13.594 -16.893 1.00 1.00 H +ATOM 1059 H5'' U A 33 -8.447 -14.717 -17.679 1.00 1.00 H +ATOM 1060 H4' U A 33 -7.431 -12.494 -17.300 1.00 1.00 H +ATOM 1061 H3' U A 33 -6.284 -14.883 -15.866 1.00 1.00 H +ATOM 1062 H2' U A 33 -4.839 -13.571 -14.619 1.00 1.00 H +ATOM 1063 HO2' U A 33 -3.782 -12.532 -16.280 1.00 1.00 H +ATOM 1064 H1' U A 33 -6.335 -11.167 -14.592 1.00 1.00 H +ATOM 1065 H3 U A 33 -5.876 -11.901 -10.151 1.00 1.00 H +ATOM 1066 H5 U A 33 -8.260 -15.124 -11.454 1.00 1.00 H +ATOM 1067 H6 U A 33 -7.942 -14.351 -13.733 1.00 1.00 H +ATOM 1068 P C A 34 -4.339 -15.049 -17.808 1.00 1.00 P +ATOM 1069 OP1 C A 34 -3.854 -14.893 -19.199 1.00 1.00 O +ATOM 1070 OP2 C A 34 -4.860 -16.356 -17.351 1.00 1.00 O +ATOM 1071 O5' C A 34 -3.159 -14.599 -16.810 1.00 1.00 O +ATOM 1072 C5' C A 34 -2.350 -15.580 -16.157 1.00 1.00 C +ATOM 1073 C4' C A 34 -1.289 -14.934 -15.271 1.00 1.00 C +ATOM 1074 O4' C A 34 -1.917 -14.122 -14.281 1.00 1.00 O +ATOM 1075 C3' C A 34 -0.409 -15.931 -14.533 1.00 1.00 C +ATOM 1076 O3' C A 34 0.781 -16.172 -15.291 1.00 1.00 O +ATOM 1077 C2' C A 34 -0.055 -15.224 -13.233 1.00 1.00 C +ATOM 1078 O2' C A 34 1.228 -14.596 -13.318 1.00 1.00 O +ATOM 1079 C1' C A 34 -1.170 -14.190 -13.058 1.00 1.00 C +ATOM 1080 N1 C A 34 -2.120 -14.509 -11.976 1.00 1.00 N +ATOM 1081 C2 C A 34 -1.708 -14.272 -10.674 1.00 1.00 C +ATOM 1082 O2 C A 34 -0.588 -13.813 -10.458 1.00 1.00 O +ATOM 1083 N3 C A 34 -2.570 -14.559 -9.662 1.00 1.00 N +ATOM 1084 C4 C A 34 -3.788 -15.057 -9.915 1.00 1.00 C +ATOM 1085 N4 C A 34 -4.607 -15.327 -8.900 1.00 1.00 N +ATOM 1086 C5 C A 34 -4.217 -15.304 -11.257 1.00 1.00 C +ATOM 1087 C6 C A 34 -3.356 -15.017 -12.252 1.00 1.00 C +ATOM 1088 H5' C A 34 -1.858 -16.195 -16.910 1.00 1.00 H +ATOM 1089 H5'' C A 34 -2.989 -16.214 -15.542 1.00 1.00 H +ATOM 1090 H4' C A 34 -0.657 -14.296 -15.887 1.00 1.00 H +ATOM 1091 H3' C A 34 -0.950 -16.858 -14.340 1.00 1.00 H +ATOM 1092 H2' C A 34 -0.080 -15.938 -12.407 1.00 1.00 H +ATOM 1093 HO2' C A 34 1.667 -14.948 -14.096 1.00 1.00 H +ATOM 1094 H1' C A 34 -0.723 -13.216 -12.859 1.00 1.00 H +ATOM 1095 H41 C A 34 -4.310 -15.155 -7.947 1.00 1.00 H +ATOM 1096 H42 C A 34 -5.528 -15.703 -9.080 1.00 1.00 H +ATOM 1097 H5 C A 34 -5.207 -15.708 -11.467 1.00 1.00 H +ATOM 1098 H6 C A 34 -3.649 -15.191 -13.288 1.00 1.00 H +ATOM 1099 P C A 35 1.608 -17.541 -15.101 1.00 1.00 P +ATOM 1100 OP1 C A 35 2.879 -17.422 -15.849 1.00 1.00 O +ATOM 1101 OP2 C A 35 0.696 -18.676 -15.370 1.00 1.00 O +ATOM 1102 O5' C A 35 1.948 -17.530 -13.528 1.00 1.00 O +ATOM 1103 C5' C A 35 1.807 -18.719 -12.746 1.00 1.00 C +ATOM 1104 C4' C A 35 2.645 -18.655 -11.472 1.00 1.00 C +ATOM 1105 O4' C A 35 2.214 -17.558 -10.665 1.00 1.00 O +ATOM 1106 C3' C A 35 2.560 -19.910 -10.616 1.00 1.00 C +ATOM 1107 O3' C A 35 3.667 -20.767 -10.913 1.00 1.00 O +ATOM 1108 C2' C A 35 2.668 -19.395 -9.189 1.00 1.00 C +ATOM 1109 O2' C A 35 4.018 -19.454 -8.714 1.00 1.00 O +ATOM 1110 C1' C A 35 2.176 -17.954 -9.288 1.00 1.00 C +ATOM 1111 N1 C A 35 0.792 -17.760 -8.813 1.00 1.00 N +ATOM 1112 C2 C A 35 0.578 -17.792 -7.445 1.00 1.00 C +ATOM 1113 O2 C A 35 1.522 -17.977 -6.679 1.00 1.00 O +ATOM 1114 N3 C A 35 -0.691 -17.615 -6.985 1.00 1.00 N +ATOM 1115 C4 C A 35 -1.709 -17.415 -7.834 1.00 1.00 C +ATOM 1116 N4 C A 35 -2.939 -17.246 -7.351 1.00 1.00 N +ATOM 1117 C5 C A 35 -1.492 -17.382 -9.247 1.00 1.00 C +ATOM 1118 C6 C A 35 -0.233 -17.558 -9.692 1.00 1.00 C +ATOM 1119 H5' C A 35 2.125 -19.576 -13.338 1.00 1.00 H +ATOM 1120 H5'' C A 35 0.757 -18.844 -12.474 1.00 1.00 H +ATOM 1121 H4' C A 35 3.685 -18.490 -11.746 1.00 1.00 H +ATOM 1122 H3' C A 35 1.610 -20.423 -10.771 1.00 1.00 H +ATOM 1123 H2' C A 35 2.005 -19.971 -8.537 1.00 1.00 H +ATOM 1124 HO2' C A 35 4.032 -20.067 -7.974 1.00 1.00 H +ATOM 1125 H1' C A 35 2.839 -17.308 -8.712 1.00 1.00 H +ATOM 1126 H41 C A 35 -3.097 -17.267 -6.356 1.00 1.00 H +ATOM 1127 H42 C A 35 -3.713 -17.094 -7.982 1.00 1.00 H +ATOM 1128 H5 C A 35 -2.318 -17.221 -9.940 1.00 1.00 H +ATOM 1129 H6 C A 35 -0.030 -17.539 -10.763 1.00 1.00 H +ATOM 1130 P U A 36 3.602 -22.334 -10.555 1.00 1.00 P +ATOM 1131 OP1 U A 36 4.657 -23.032 -11.323 1.00 1.00 O +ATOM 1132 OP2 U A 36 2.194 -22.778 -10.662 1.00 1.00 O +ATOM 1133 O5' U A 36 4.016 -22.348 -8.999 1.00 1.00 O +ATOM 1134 C5' U A 36 3.184 -22.994 -8.032 1.00 1.00 C +ATOM 1135 C4' U A 36 3.562 -22.588 -6.609 1.00 1.00 C +ATOM 1136 O4' U A 36 2.813 -21.434 -6.223 1.00 1.00 O +ATOM 1137 C3' U A 36 3.294 -23.670 -5.572 1.00 1.00 C +ATOM 1138 O3' U A 36 4.498 -24.404 -5.327 1.00 1.00 O +ATOM 1139 C2' U A 36 2.899 -22.900 -4.325 1.00 1.00 C +ATOM 1140 O2' U A 36 4.023 -22.696 -3.459 1.00 1.00 O +ATOM 1141 C1' U A 36 2.370 -21.577 -4.867 1.00 1.00 C +ATOM 1142 N1 U A 36 0.899 -21.477 -4.862 1.00 1.00 N +ATOM 1143 C2 U A 36 0.271 -21.518 -3.631 1.00 1.00 C +ATOM 1144 O2 U A 36 0.899 -21.640 -2.582 1.00 1.00 O +ATOM 1145 N3 U A 36 -1.108 -21.415 -3.650 1.00 1.00 N +ATOM 1146 C4 U A 36 -1.901 -21.276 -4.776 1.00 1.00 C +ATOM 1147 O4 U A 36 -3.123 -21.190 -4.674 1.00 1.00 O +ATOM 1148 C5 U A 36 -1.162 -21.242 -6.017 1.00 1.00 C +ATOM 1149 C6 U A 36 0.190 -21.342 -6.025 1.00 1.00 C +ATOM 1150 H5' U A 36 3.289 -24.073 -8.133 1.00 1.00 H +ATOM 1151 H5'' U A 36 2.146 -22.718 -8.216 1.00 1.00 H +ATOM 1152 H4' U A 36 4.621 -22.335 -6.587 1.00 1.00 H +ATOM 1153 H3' U A 36 2.487 -24.328 -5.895 1.00 1.00 H +ATOM 1154 H2' U A 36 2.101 -23.430 -3.799 1.00 1.00 H +ATOM 1155 HO2' U A 36 3.694 -22.284 -2.656 1.00 1.00 H +ATOM 1156 H1' U A 36 2.779 -20.761 -4.273 1.00 1.00 H +ATOM 1157 H3 U A 36 -1.580 -21.442 -2.757 1.00 1.00 H +ATOM 1158 H5 U A 36 -1.699 -21.135 -6.959 1.00 1.00 H +ATOM 1159 H6 U A 36 0.722 -21.315 -6.975 1.00 1.00 H +ATOM 1160 P A A 37 4.443 -25.933 -4.825 1.00 1.00 P +ATOM 1161 OP1 A A 37 5.825 -26.464 -4.803 1.00 1.00 O +ATOM 1162 OP2 A A 37 3.394 -26.636 -5.596 1.00 1.00 O +ATOM 1163 O5' A A 37 3.936 -25.786 -3.303 1.00 1.00 O +ATOM 1164 C5' A A 37 4.681 -25.012 -2.359 1.00 1.00 C +ATOM 1165 C4' A A 37 4.079 -25.104 -0.959 1.00 1.00 C +ATOM 1166 O4' A A 37 2.774 -24.519 -0.964 1.00 1.00 O +ATOM 1167 C3' A A 37 3.940 -26.533 -0.443 1.00 1.00 C +ATOM 1168 O3' A A 37 4.230 -26.564 0.959 1.00 1.00 O +ATOM 1169 C2' A A 37 2.476 -26.875 -0.669 1.00 1.00 C +ATOM 1170 O2' A A 37 1.970 -27.712 0.376 1.00 1.00 O +ATOM 1171 C1' A A 37 1.787 -25.516 -0.673 1.00 1.00 C +ATOM 1172 N9 A A 37 0.714 -25.392 -1.678 1.00 1.00 N +ATOM 1173 C8 A A 37 0.765 -25.639 -3.025 1.00 1.00 C +ATOM 1174 N7 A A 37 -0.366 -25.432 -3.642 1.00 1.00 N +ATOM 1175 C5 A A 37 -1.225 -25.017 -2.631 1.00 1.00 C +ATOM 1176 C6 A A 37 -2.578 -24.639 -2.631 1.00 1.00 C +ATOM 1177 N6 A A 37 -3.331 -24.620 -3.732 1.00 1.00 N +ATOM 1178 N1 A A 37 -3.120 -24.285 -1.454 1.00 1.00 N +ATOM 1179 C2 A A 37 -2.365 -24.307 -0.361 1.00 1.00 C +ATOM 1180 N3 A A 37 -1.090 -24.640 -0.232 1.00 1.00 N +ATOM 1181 C4 A A 37 -0.575 -24.990 -1.430 1.00 1.00 C +ATOM 1182 H5' A A 37 4.687 -23.971 -2.676 1.00 1.00 H +ATOM 1183 H5'' A A 37 5.707 -25.382 -2.329 1.00 1.00 H +ATOM 1184 H4' A A 37 4.706 -24.540 -0.270 1.00 1.00 H +ATOM 1185 H3' A A 37 4.588 -27.213 -0.998 1.00 1.00 H +ATOM 1186 H2' A A 37 2.353 -27.355 -1.643 1.00 1.00 H +ATOM 1187 HO2' A A 37 1.025 -27.556 0.435 1.00 1.00 H +ATOM 1188 H1' A A 37 1.370 -25.326 0.316 1.00 1.00 H +ATOM 1189 H8 A A 37 1.667 -25.979 -3.535 1.00 1.00 H +ATOM 1190 H61 A A 37 -4.300 -24.340 -3.677 1.00 1.00 H +ATOM 1191 H62 A A 37 -2.932 -24.886 -4.621 1.00 1.00 H +ATOM 1192 H2 A A 37 -2.867 -24.007 0.559 1.00 1.00 H +ATOM 1193 P A A 38 4.678 -27.938 1.671 1.00 1.00 P +ATOM 1194 OP1 A A 38 6.095 -28.195 1.331 1.00 1.00 O +ATOM 1195 OP2 A A 38 3.652 -28.964 1.384 1.00 1.00 O +ATOM 1196 O5' A A 38 4.597 -27.568 3.237 1.00 1.00 O +ATOM 1197 C5' A A 38 5.749 -27.079 3.928 1.00 1.00 C +ATOM 1198 C4' A A 38 5.378 -26.010 4.954 1.00 1.00 C +ATOM 1199 O4' A A 38 4.867 -24.860 4.280 1.00 1.00 O +ATOM 1200 C3' A A 38 4.321 -26.453 5.955 1.00 1.00 C +ATOM 1201 O3' A A 38 4.954 -26.908 7.154 1.00 1.00 O +ATOM 1202 C2' A A 38 3.531 -25.188 6.247 1.00 1.00 C +ATOM 1203 O2' A A 38 3.997 -24.549 7.440 1.00 1.00 O +ATOM 1204 C1' A A 38 3.770 -24.312 5.021 1.00 1.00 C +ATOM 1205 N9 A A 38 2.612 -24.235 4.113 1.00 1.00 N +ATOM 1206 C8 A A 38 2.377 -24.929 2.954 1.00 1.00 C +ATOM 1207 N7 A A 38 1.246 -24.627 2.379 1.00 1.00 N +ATOM 1208 C5 A A 38 0.693 -23.664 3.218 1.00 1.00 C +ATOM 1209 C6 A A 38 -0.508 -22.937 3.166 1.00 1.00 C +ATOM 1210 N6 A A 38 -1.407 -23.076 2.190 1.00 1.00 N +ATOM 1211 N1 A A 38 -0.743 -22.063 4.160 1.00 1.00 N +ATOM 1212 C2 A A 38 0.153 -21.929 5.130 1.00 1.00 C +ATOM 1213 N3 A A 38 1.312 -22.552 5.289 1.00 1.00 N +ATOM 1214 C4 A A 38 1.519 -23.420 4.277 1.00 1.00 C +ATOM 1215 H5' A A 38 6.444 -26.652 3.205 1.00 1.00 H +ATOM 1216 H5'' A A 38 6.235 -27.909 4.440 1.00 1.00 H +ATOM 1217 H4' A A 38 6.275 -25.718 5.496 1.00 1.00 H +ATOM 1218 H3' A A 38 3.678 -27.225 5.527 1.00 1.00 H +ATOM 1219 H2' A A 38 2.467 -25.426 6.330 1.00 1.00 H +ATOM 1220 HO2' A A 38 3.291 -24.605 8.087 1.00 1.00 H +ATOM 1221 H1' A A 38 4.028 -23.305 5.347 1.00 1.00 H +ATOM 1222 H8 A A 38 3.073 -25.665 2.551 1.00 1.00 H +ATOM 1223 H61 A A 38 -2.254 -22.529 2.201 1.00 1.00 H +ATOM 1224 H62 A A 38 -1.238 -23.731 1.439 1.00 1.00 H +ATOM 1225 H2 A A 38 -0.100 -21.204 5.903 1.00 1.00 H +ATOM 1226 P G A 39 4.082 -27.562 8.341 1.00 1.00 P +ATOM 1227 OP1 G A 39 5.014 -28.105 9.353 1.00 1.00 O +ATOM 1228 OP2 G A 39 3.057 -28.440 7.734 1.00 1.00 O +ATOM 1229 O5' G A 39 3.340 -26.280 8.975 1.00 1.00 O +ATOM 1230 C5' G A 39 2.125 -26.429 9.718 1.00 1.00 C +ATOM 1231 C4' G A 39 1.273 -25.163 9.654 1.00 1.00 C +ATOM 1232 O4' G A 39 1.272 -24.649 8.319 1.00 1.00 O +ATOM 1233 C3' G A 39 -0.179 -25.371 10.066 1.00 1.00 C +ATOM 1234 O3' G A 39 -0.357 -24.967 11.426 1.00 1.00 O +ATOM 1235 C2' G A 39 -0.957 -24.442 9.148 1.00 1.00 C +ATOM 1236 O2' G A 39 -1.158 -23.160 9.750 1.00 1.00 O +ATOM 1237 C1' G A 39 -0.070 -24.345 7.915 1.00 1.00 C +ATOM 1238 N9 G A 39 -0.432 -25.293 6.847 1.00 1.00 N +ATOM 1239 C8 G A 39 0.085 -26.539 6.599 1.00 1.00 C +ATOM 1240 N7 G A 39 -0.450 -27.137 5.571 1.00 1.00 N +ATOM 1241 C5 G A 39 -1.389 -26.224 5.102 1.00 1.00 C +ATOM 1242 C6 G A 39 -2.282 -26.321 3.999 1.00 1.00 C +ATOM 1243 O6 G A 39 -2.420 -27.251 3.208 1.00 1.00 O +ATOM 1244 N1 G A 39 -3.061 -25.178 3.873 1.00 1.00 N +ATOM 1245 C2 G A 39 -2.990 -24.078 4.702 1.00 1.00 C +ATOM 1246 N2 G A 39 -3.820 -23.074 4.419 1.00 1.00 N +ATOM 1247 N3 G A 39 -2.152 -23.985 5.739 1.00 1.00 N +ATOM 1248 C4 G A 39 -1.384 -25.091 5.878 1.00 1.00 C +ATOM 1249 H5' G A 39 2.369 -26.640 10.758 1.00 1.00 H +ATOM 1250 H5'' G A 39 1.557 -27.266 9.312 1.00 1.00 H +ATOM 1251 H4' G A 39 1.715 -24.413 10.307 1.00 1.00 H +ATOM 1252 H3' G A 39 -0.482 -26.409 9.918 1.00 1.00 H +ATOM 1253 H2' G A 39 -1.912 -24.896 8.881 1.00 1.00 H +ATOM 1254 HO2' G A 39 -2.105 -23.055 9.884 1.00 1.00 H +ATOM 1255 H1' G A 39 -0.109 -23.330 7.522 1.00 1.00 H +ATOM 1256 H8 G A 39 0.872 -26.988 7.204 1.00 1.00 H +ATOM 1257 H1 G A 39 -3.721 -25.172 3.110 1.00 1.00 H +ATOM 1258 H21 G A 39 -4.452 -23.147 3.636 1.00 1.00 H +ATOM 1259 H22 G A 39 -3.817 -22.240 4.990 1.00 1.00 H +ATOM 1260 P U A 40 -1.270 -25.838 12.427 1.00 1.00 P +ATOM 1261 OP1 U A 40 -1.316 -25.146 13.734 1.00 1.00 O +ATOM 1262 OP2 U A 40 -0.820 -27.247 12.355 1.00 1.00 O +ATOM 1263 O5' U A 40 -2.731 -25.743 11.756 1.00 1.00 O +ATOM 1264 C5' U A 40 -3.573 -24.612 11.999 1.00 1.00 C +ATOM 1265 C4' U A 40 -4.932 -24.771 11.325 1.00 1.00 C +ATOM 1266 O4' U A 40 -4.776 -24.687 9.910 1.00 1.00 O +ATOM 1267 C3' U A 40 -5.618 -26.095 11.621 1.00 1.00 C +ATOM 1268 O3' U A 40 -6.503 -25.942 12.735 1.00 1.00 O +ATOM 1269 C2' U A 40 -6.415 -26.373 10.356 1.00 1.00 C +ATOM 1270 O2' U A 40 -7.743 -25.849 10.446 1.00 1.00 O +ATOM 1271 C1' U A 40 -5.609 -25.665 9.269 1.00 1.00 C +ATOM 1272 N1 U A 40 -4.716 -26.565 8.510 1.00 1.00 N +ATOM 1273 C2 U A 40 -5.165 -27.048 7.295 1.00 1.00 C +ATOM 1274 O2 U A 40 -6.271 -26.757 6.845 1.00 1.00 O +ATOM 1275 N3 U A 40 -4.296 -27.881 6.614 1.00 1.00 N +ATOM 1276 C4 U A 40 -3.035 -28.268 7.038 1.00 1.00 C +ATOM 1277 O4 U A 40 -2.345 -29.015 6.347 1.00 1.00 O +ATOM 1278 C5 U A 40 -2.649 -27.716 8.317 1.00 1.00 C +ATOM 1279 C6 U A 40 -3.483 -26.897 9.002 1.00 1.00 C +ATOM 1280 H5' U A 40 -3.087 -23.718 11.608 1.00 1.00 H +ATOM 1281 H5'' U A 40 -3.718 -24.498 13.073 1.00 1.00 H +ATOM 1282 H4' U A 40 -5.583 -23.960 11.648 1.00 1.00 H +ATOM 1283 H3' U A 40 -4.884 -26.882 11.801 1.00 1.00 H +ATOM 1284 H2' U A 40 -6.436 -27.444 10.159 1.00 1.00 H +ATOM 1285 HO2' U A 40 -8.325 -26.479 10.010 1.00 1.00 H +ATOM 1286 H1' U A 40 -6.290 -25.162 8.582 1.00 1.00 H +ATOM 1287 H3 U A 40 -4.611 -28.242 5.725 1.00 1.00 H +ATOM 1288 H5 U A 40 -1.673 -27.962 8.736 1.00 1.00 H +ATOM 1289 H6 U A 40 -3.166 -26.496 9.964 1.00 1.00 H +ATOM 1290 P C A 41 -6.558 -27.057 13.896 1.00 1.00 P +ATOM 1291 OP1 C A 41 -7.481 -26.584 14.952 1.00 1.00 O +ATOM 1292 OP2 C A 41 -5.168 -27.429 14.245 1.00 1.00 O +ATOM 1293 O5' C A 41 -7.243 -28.313 13.156 1.00 1.00 O +ATOM 1294 C5' C A 41 -8.661 -28.369 12.980 1.00 1.00 C +ATOM 1295 C4' C A 41 -9.046 -29.370 11.894 1.00 1.00 C +ATOM 1296 O4' C A 41 -8.323 -29.093 10.697 1.00 1.00 O +ATOM 1297 C3' C A 41 -8.748 -30.815 12.250 1.00 1.00 C +ATOM 1298 O3' C A 41 -9.880 -31.401 12.906 1.00 1.00 O +ATOM 1299 C2' C A 41 -8.529 -31.475 10.899 1.00 1.00 C +ATOM 1300 O2' C A 41 -9.734 -32.068 10.406 1.00 1.00 O +ATOM 1301 C1' C A 41 -8.063 -30.325 10.005 1.00 1.00 C +ATOM 1302 N1 C A 41 -6.617 -30.371 9.691 1.00 1.00 N +ATOM 1303 C2 C A 41 -6.238 -30.964 8.496 1.00 1.00 C +ATOM 1304 O2 C A 41 -7.091 -31.431 7.744 1.00 1.00 O +ATOM 1305 N3 C A 41 -4.913 -31.013 8.192 1.00 1.00 N +ATOM 1306 C4 C A 41 -3.996 -30.501 9.024 1.00 1.00 C +ATOM 1307 N4 C A 41 -2.705 -30.566 8.697 1.00 1.00 N +ATOM 1308 C5 C A 41 -4.383 -29.887 10.256 1.00 1.00 C +ATOM 1309 C6 C A 41 -5.697 -29.843 10.549 1.00 1.00 C +ATOM 1310 H5' C A 41 -9.023 -27.382 12.697 1.00 1.00 H +ATOM 1311 H5'' C A 41 -9.126 -28.665 13.919 1.00 1.00 H +ATOM 1312 H4' C A 41 -10.108 -29.271 11.684 1.00 1.00 H +ATOM 1313 H3' C A 41 -7.851 -30.884 12.868 1.00 1.00 H +ATOM 1314 H2' C A 41 -7.738 -32.220 10.979 1.00 1.00 H +ATOM 1315 HO2' C A 41 -10.146 -32.530 11.141 1.00 1.00 H +ATOM 1316 H1' C A 41 -8.635 -30.336 9.075 1.00 1.00 H +ATOM 1317 H41 C A 41 -2.427 -30.997 7.829 1.00 1.00 H +ATOM 1318 H42 C A 41 -2.007 -30.183 9.317 1.00 1.00 H +ATOM 1319 H5 C A 41 -3.639 -29.469 10.936 1.00 1.00 H +ATOM 1320 H6 C A 41 -6.028 -29.383 11.480 1.00 1.00 H +ATOM 1321 P C A 42 -9.679 -32.613 13.953 1.00 1.00 P +ATOM 1322 OP1 C A 42 -10.876 -32.678 14.821 1.00 1.00 O +ATOM 1323 OP2 C A 42 -8.336 -32.482 14.560 1.00 1.00 O +ATOM 1324 O5' C A 42 -9.676 -33.914 13.003 1.00 1.00 O +ATOM 1325 C5' C A 42 -10.900 -34.429 12.471 1.00 1.00 C +ATOM 1326 C4' C A 42 -10.645 -35.455 11.369 1.00 1.00 C +ATOM 1327 O4' C A 42 -9.751 -34.909 10.401 1.00 1.00 O +ATOM 1328 C3' C A 42 -10.013 -36.747 11.855 1.00 1.00 C +ATOM 1329 O3' C A 42 -11.031 -37.699 12.179 1.00 1.00 O +ATOM 1330 C2' C A 42 -9.224 -37.234 10.652 1.00 1.00 C +ATOM 1331 O2' C A 42 -9.993 -38.143 9.857 1.00 1.00 O +ATOM 1332 C1' C A 42 -8.915 -35.957 9.880 1.00 1.00 C +ATOM 1333 N1 C A 42 -7.512 -35.517 10.003 1.00 1.00 N +ATOM 1334 C2 C A 42 -6.613 -35.965 9.048 1.00 1.00 C +ATOM 1335 O2 C A 42 -6.992 -36.711 8.148 1.00 1.00 O +ATOM 1336 N3 C A 42 -5.316 -35.560 9.143 1.00 1.00 N +ATOM 1337 C4 C A 42 -4.919 -34.750 10.133 1.00 1.00 C +ATOM 1338 N4 C A 42 -3.642 -34.372 10.194 1.00 1.00 N +ATOM 1339 C5 C A 42 -5.843 -34.286 11.121 1.00 1.00 C +ATOM 1340 C6 C A 42 -7.124 -34.691 11.019 1.00 1.00 C +ATOM 1341 H5' C A 42 -11.486 -33.607 12.062 1.00 1.00 H +ATOM 1342 H5'' C A 42 -11.463 -34.904 13.274 1.00 1.00 H +ATOM 1343 H4' C A 42 -11.587 -35.685 10.875 1.00 1.00 H +ATOM 1344 H3' C A 42 -9.354 -36.564 12.706 1.00 1.00 H +ATOM 1345 H2' C A 42 -8.295 -37.702 10.980 1.00 1.00 H +ATOM 1346 HO2' C A 42 -10.891 -37.806 9.826 1.00 1.00 H +ATOM 1347 H1' C A 42 -9.153 -36.110 8.828 1.00 1.00 H +ATOM 1348 H41 C A 42 -2.985 -34.696 9.499 1.00 1.00 H +ATOM 1349 H42 C A 42 -3.332 -33.760 10.936 1.00 1.00 H +ATOM 1350 H5 C A 42 -5.524 -33.627 11.928 1.00 1.00 H +ATOM 1351 H6 C A 42 -7.857 -34.360 11.755 1.00 1.00 H +ATOM 1352 P U A 43 -10.674 -39.008 13.044 1.00 1.00 P +ATOM 1353 OP1 U A 43 -11.822 -39.938 12.972 1.00 1.00 O +ATOM 1354 OP2 U A 43 -10.158 -38.569 14.361 1.00 1.00 O +ATOM 1355 O5' U A 43 -9.454 -39.651 12.215 1.00 1.00 O +ATOM 1356 C5' U A 43 -9.703 -40.382 11.013 1.00 1.00 C +ATOM 1357 C4' U A 43 -8.415 -40.938 10.411 1.00 1.00 C +ATOM 1358 O4' U A 43 -7.462 -39.897 10.238 1.00 1.00 O +ATOM 1359 C3' U A 43 -7.738 -42.005 11.264 1.00 1.00 C +ATOM 1360 O3' U A 43 -8.105 -43.319 10.832 1.00 1.00 O +ATOM 1361 C2' U A 43 -6.238 -41.750 11.059 1.00 1.00 C +ATOM 1362 O2' U A 43 -5.605 -42.869 10.429 1.00 1.00 O +ATOM 1363 C1' U A 43 -6.183 -40.515 10.168 1.00 1.00 C +ATOM 1364 N1 U A 43 -5.161 -39.527 10.579 1.00 1.00 N +ATOM 1365 C2 U A 43 -3.918 -39.617 9.983 1.00 1.00 C +ATOM 1366 O2 U A 43 -3.658 -40.473 9.139 1.00 1.00 O +ATOM 1367 N3 U A 43 -2.979 -38.688 10.392 1.00 1.00 N +ATOM 1368 C4 U A 43 -3.173 -37.691 11.332 1.00 1.00 C +ATOM 1369 O4 U A 43 -2.265 -36.912 11.617 1.00 1.00 O +ATOM 1370 C5 U A 43 -4.502 -37.672 11.903 1.00 1.00 C +ATOM 1371 C6 U A 43 -5.438 -38.573 11.518 1.00 1.00 C +ATOM 1372 H5' U A 43 -10.179 -39.720 10.288 1.00 1.00 H +ATOM 1373 H5'' U A 43 -10.379 -41.209 11.236 1.00 1.00 H +ATOM 1374 H4' U A 43 -8.641 -41.359 9.434 1.00 1.00 H +ATOM 1375 H3' U A 43 -8.000 -41.860 12.317 1.00 1.00 H +ATOM 1376 HO3' U A 43 -7.701 -43.462 9.973 1.00 1.00 H +ATOM 1377 H2' U A 43 -5.761 -41.530 12.017 1.00 1.00 H +ATOM 1378 HO2' U A 43 -5.153 -42.540 9.647 1.00 1.00 H +ATOM 1379 H1' U A 43 -5.994 -40.825 9.141 1.00 1.00 H +ATOM 1380 H3 U A 43 -2.065 -38.742 9.963 1.00 1.00 H +ATOM 1381 H5 U A 43 -4.754 -36.923 12.655 1.00 1.00 H +ATOM 1382 H6 U A 43 -6.431 -38.535 11.966 1.00 1.00 H +TER 1383 U A 43 +ATOM 1384 O5' G B 44 -5.053 36.645 16.249 1.00 1.00 O +ATOM 1385 C5' G B 44 -5.933 37.488 15.503 1.00 1.00 C +ATOM 1386 C4' G B 44 -5.185 38.240 14.405 1.00 1.00 C +ATOM 1387 O4' G B 44 -4.353 39.246 14.993 1.00 1.00 O +ATOM 1388 C3' G B 44 -4.292 37.348 13.547 1.00 1.00 C +ATOM 1389 O3' G B 44 -4.948 37.056 12.309 1.00 1.00 O +ATOM 1390 C2' G B 44 -3.062 38.201 13.289 1.00 1.00 C +ATOM 1391 O2' G B 44 -3.192 38.958 12.081 1.00 1.00 O +ATOM 1392 C1' G B 44 -3.014 39.104 14.509 1.00 1.00 C +ATOM 1393 N9 G B 44 -2.212 38.563 15.612 1.00 1.00 N +ATOM 1394 C8 G B 44 -2.639 38.100 16.829 1.00 1.00 C +ATOM 1395 N7 G B 44 -1.678 37.670 17.598 1.00 1.00 N +ATOM 1396 C5 G B 44 -0.527 37.864 16.838 1.00 1.00 C +ATOM 1397 C6 G B 44 0.830 37.582 17.153 1.00 1.00 C +ATOM 1398 O6 G B 44 1.288 37.095 18.185 1.00 1.00 O +ATOM 1399 N1 G B 44 1.678 37.927 16.110 1.00 1.00 N +ATOM 1400 C2 G B 44 1.275 38.476 14.911 1.00 1.00 C +ATOM 1401 N2 G B 44 2.240 38.740 14.030 1.00 1.00 N +ATOM 1402 N3 G B 44 -0.001 38.743 14.612 1.00 1.00 N +ATOM 1403 C4 G B 44 -0.844 38.410 15.620 1.00 1.00 C +ATOM 1404 H5' G B 44 -6.398 38.204 16.185 1.00 1.00 H +ATOM 1405 H5'' G B 44 -6.709 36.881 15.046 1.00 1.00 H +ATOM 1406 H4' G B 44 -5.912 38.730 13.759 1.00 1.00 H +ATOM 1407 H3' G B 44 -4.027 36.434 14.080 1.00 1.00 H +ATOM 1408 H2' G B 44 -2.171 37.572 13.257 1.00 1.00 H +ATOM 1409 HO2' G B 44 -3.452 39.847 12.329 1.00 1.00 H +ATOM 1410 H1' G B 44 -2.625 40.079 14.224 1.00 1.00 H +ATOM 1411 H8 G B 44 -3.686 38.091 17.127 1.00 1.00 H +ATOM 1412 H1 G B 44 2.662 37.754 16.262 1.00 1.00 H +ATOM 1413 H21 G B 44 3.202 38.538 14.260 1.00 1.00 H +ATOM 1414 H22 G B 44 2.009 39.144 13.133 1.00 1.00 H +ATOM 1415 HO5' G B 44 -5.403 35.752 16.201 1.00 1.00 H +ATOM 1416 P G B 45 -4.583 35.719 11.488 1.00 1.00 P +ATOM 1417 OP1 G B 45 -5.347 35.730 10.220 1.00 1.00 O +ATOM 1418 OP2 G B 45 -4.696 34.565 12.407 1.00 1.00 O +ATOM 1419 O5' G B 45 -3.024 35.934 11.139 1.00 1.00 O +ATOM 1420 C5' G B 45 -2.605 37.029 10.319 1.00 1.00 C +ATOM 1421 C4' G B 45 -1.084 37.173 10.307 1.00 1.00 C +ATOM 1422 O4' G B 45 -0.588 37.340 11.635 1.00 1.00 O +ATOM 1423 C3' G B 45 -0.352 35.979 9.719 1.00 1.00 C +ATOM 1424 O3' G B 45 -0.176 36.176 8.311 1.00 1.00 O +ATOM 1425 C2' G B 45 0.995 35.992 10.425 1.00 1.00 C +ATOM 1426 O2' G B 45 2.000 36.609 9.614 1.00 1.00 O +ATOM 1427 C1' G B 45 0.736 36.789 11.708 1.00 1.00 C +ATOM 1428 N9 G B 45 0.837 35.984 12.938 1.00 1.00 N +ATOM 1429 C8 G B 45 -0.157 35.439 13.709 1.00 1.00 C +ATOM 1430 N7 G B 45 0.280 34.783 14.748 1.00 1.00 N +ATOM 1431 C5 G B 45 1.664 34.902 14.662 1.00 1.00 C +ATOM 1432 C6 G B 45 2.678 34.391 15.519 1.00 1.00 C +ATOM 1433 O6 G B 45 2.547 33.720 16.542 1.00 1.00 O +ATOM 1434 N1 G B 45 3.946 34.739 15.073 1.00 1.00 N +ATOM 1435 C2 G B 45 4.208 35.485 13.943 1.00 1.00 C +ATOM 1436 N2 G B 45 5.493 35.717 13.674 1.00 1.00 N +ATOM 1437 N3 G B 45 3.257 35.965 13.137 1.00 1.00 N +ATOM 1438 C4 G B 45 2.014 35.636 13.557 1.00 1.00 C +ATOM 1439 H5' G B 45 -3.048 37.948 10.700 1.00 1.00 H +ATOM 1440 H5'' G B 45 -2.955 36.861 9.299 1.00 1.00 H +ATOM 1441 H4' G B 45 -0.823 38.058 9.732 1.00 1.00 H +ATOM 1442 H3' G B 45 -0.890 35.052 9.924 1.00 1.00 H +ATOM 1443 H2' G B 45 1.284 34.971 10.679 1.00 1.00 H +ATOM 1444 HO2' G B 45 2.373 35.921 9.054 1.00 1.00 H +ATOM 1445 H1' G B 45 1.458 37.603 11.773 1.00 1.00 H +ATOM 1446 H8 G B 45 -1.216 35.540 13.473 1.00 1.00 H +ATOM 1447 H1 G B 45 4.721 34.410 15.631 1.00 1.00 H +ATOM 1448 H21 G B 45 6.207 35.356 14.280 1.00 1.00 H +ATOM 1449 H22 G B 45 5.746 36.258 12.859 1.00 1.00 H +ATOM 1450 P G B 46 0.070 34.924 7.327 1.00 1.00 P +ATOM 1451 OP1 G B 46 -0.395 35.299 5.972 1.00 1.00 O +ATOM 1452 OP2 G B 46 -0.470 33.711 7.982 1.00 1.00 O +ATOM 1453 O5' G B 46 1.677 34.804 7.293 1.00 1.00 O +ATOM 1454 C5' G B 46 2.478 35.858 6.747 1.00 1.00 C +ATOM 1455 C4' G B 46 3.938 35.728 7.173 1.00 1.00 C +ATOM 1456 O4' G B 46 4.017 35.663 8.598 1.00 1.00 O +ATOM 1457 C3' G B 46 4.633 34.490 6.621 1.00 1.00 C +ATOM 1458 O3' G B 46 5.374 34.838 5.445 1.00 1.00 O +ATOM 1459 C2' G B 46 5.588 34.082 7.730 1.00 1.00 C +ATOM 1460 O2' G B 46 6.886 34.654 7.537 1.00 1.00 O +ATOM 1461 C1' G B 46 4.921 34.623 8.991 1.00 1.00 C +ATOM 1462 N9 G B 46 4.142 33.615 9.734 1.00 1.00 N +ATOM 1463 C8 G B 46 2.830 33.250 9.567 1.00 1.00 C +ATOM 1464 N7 G B 46 2.432 32.322 10.392 1.00 1.00 N +ATOM 1465 C5 G B 46 3.559 32.051 11.162 1.00 1.00 C +ATOM 1466 C6 G B 46 3.735 31.126 12.229 1.00 1.00 C +ATOM 1467 O6 G B 46 2.911 30.350 12.710 1.00 1.00 O +ATOM 1468 N1 G B 46 5.028 31.169 12.732 1.00 1.00 N +ATOM 1469 C2 G B 46 6.029 31.995 12.270 1.00 1.00 C +ATOM 1470 N2 G B 46 7.208 31.892 12.881 1.00 1.00 N +ATOM 1471 N3 G B 46 5.866 32.867 11.270 1.00 1.00 N +ATOM 1472 C4 G B 46 4.611 32.838 10.766 1.00 1.00 C +ATOM 1473 H5' G B 46 2.090 36.815 7.092 1.00 1.00 H +ATOM 1474 H5'' G B 46 2.420 35.821 5.659 1.00 1.00 H +ATOM 1475 H4' G B 46 4.480 36.612 6.840 1.00 1.00 H +ATOM 1476 H3' G B 46 3.911 33.697 6.416 1.00 1.00 H +ATOM 1477 H2' G B 46 5.650 32.994 7.785 1.00 1.00 H +ATOM 1478 HO2' G B 46 7.182 34.986 8.388 1.00 1.00 H +ATOM 1479 H1' G B 46 5.684 35.038 9.653 1.00 1.00 H +ATOM 1480 H8 G B 46 2.180 33.694 8.813 1.00 1.00 H +ATOM 1481 H1 G B 46 5.229 30.537 13.494 1.00 1.00 H +ATOM 1482 H21 G B 46 7.328 31.235 13.637 1.00 1.00 H +ATOM 1483 H22 G B 46 7.982 32.473 12.587 1.00 1.00 H +ATOM 1484 P A B 47 5.247 33.955 4.104 1.00 1.00 P +ATOM 1485 OP1 A B 47 5.730 34.768 2.966 1.00 1.00 O +ATOM 1486 OP2 A B 47 3.890 33.364 4.064 1.00 1.00 O +ATOM 1487 O5' A B 47 6.305 32.767 4.355 1.00 1.00 O +ATOM 1488 C5' A B 47 7.698 32.965 4.098 1.00 1.00 C +ATOM 1489 C4' A B 47 8.513 31.725 4.449 1.00 1.00 C +ATOM 1490 O4' A B 47 8.469 31.517 5.856 1.00 1.00 O +ATOM 1491 C3' A B 47 8.014 30.449 3.786 1.00 1.00 C +ATOM 1492 O3' A B 47 8.784 30.193 2.607 1.00 1.00 O +ATOM 1493 C2' A B 47 8.279 29.369 4.825 1.00 1.00 C +ATOM 1494 O2' A B 47 9.553 28.747 4.617 1.00 1.00 O +ATOM 1495 C1' A B 47 8.243 30.134 6.148 1.00 1.00 C +ATOM 1496 N9 A B 47 6.953 30.053 6.852 1.00 1.00 N +ATOM 1497 C8 A B 47 5.789 30.729 6.592 1.00 1.00 C +ATOM 1498 N7 A B 47 4.806 30.418 7.393 1.00 1.00 N +ATOM 1499 C5 A B 47 5.360 29.469 8.245 1.00 1.00 C +ATOM 1500 C6 A B 47 4.832 28.742 9.325 1.00 1.00 C +ATOM 1501 N6 A B 47 3.572 28.869 9.743 1.00 1.00 N +ATOM 1502 N1 A B 47 5.655 27.883 9.951 1.00 1.00 N +ATOM 1503 C2 A B 47 6.907 27.762 9.528 1.00 1.00 C +ATOM 1504 N3 A B 47 7.518 28.385 8.531 1.00 1.00 N +ATOM 1505 C4 A B 47 6.667 29.240 7.924 1.00 1.00 C +ATOM 1506 H5' A B 47 8.054 33.804 4.695 1.00 1.00 H +ATOM 1507 H5'' A B 47 7.837 33.196 3.041 1.00 1.00 H +ATOM 1508 H4' A B 47 9.549 31.890 4.159 1.00 1.00 H +ATOM 1509 H3' A B 47 6.949 30.520 3.560 1.00 1.00 H +ATOM 1510 H2' A B 47 7.478 28.626 4.801 1.00 1.00 H +ATOM 1511 HO2' A B 47 10.178 29.443 4.402 1.00 1.00 H +ATOM 1512 H1' A B 47 9.031 29.764 6.800 1.00 1.00 H +ATOM 1513 H8 A B 47 5.691 31.459 5.787 1.00 1.00 H +ATOM 1514 H61 A B 47 3.243 28.322 10.525 1.00 1.00 H +ATOM 1515 H62 A B 47 2.948 29.513 9.279 1.00 1.00 H +ATOM 1516 H2 A B 47 7.520 27.048 10.080 1.00 1.00 H +ATOM 1517 P U B 48 8.132 29.418 1.356 1.00 1.00 P +ATOM 1518 OP1 U B 48 9.193 29.193 0.349 1.00 1.00 O +ATOM 1519 OP2 U B 48 6.887 30.121 0.973 1.00 1.00 O +ATOM 1520 O5' U B 48 7.733 27.995 1.988 1.00 1.00 O +ATOM 1521 C5' U B 48 8.743 27.058 2.373 1.00 1.00 C +ATOM 1522 C4' U B 48 8.154 25.920 3.199 1.00 1.00 C +ATOM 1523 O4' U B 48 7.521 26.460 4.348 1.00 1.00 O +ATOM 1524 C3' U B 48 7.108 25.096 2.469 1.00 1.00 C +ATOM 1525 O3' U B 48 7.733 23.956 1.876 1.00 1.00 O +ATOM 1526 C2' U B 48 6.158 24.645 3.576 1.00 1.00 C +ATOM 1527 O2' U B 48 6.456 23.313 4.006 1.00 1.00 O +ATOM 1528 C1' U B 48 6.388 25.660 4.703 1.00 1.00 C +ATOM 1529 N1 U B 48 5.253 26.584 4.920 1.00 1.00 N +ATOM 1530 C2 U B 48 4.401 26.315 5.974 1.00 1.00 C +ATOM 1531 O2 U B 48 4.562 25.347 6.713 1.00 1.00 O +ATOM 1532 N3 U B 48 3.354 27.201 6.150 1.00 1.00 N +ATOM 1533 C4 U B 48 3.087 28.316 5.374 1.00 1.00 C +ATOM 1534 O4 U B 48 2.124 29.037 5.623 1.00 1.00 O +ATOM 1535 C5 U B 48 4.029 28.520 4.295 1.00 1.00 C +ATOM 1536 C6 U B 48 5.063 27.666 4.104 1.00 1.00 C +ATOM 1537 H5' U B 48 9.499 27.574 2.965 1.00 1.00 H +ATOM 1538 H5'' U B 48 9.210 26.648 1.477 1.00 1.00 H +ATOM 1539 H4' U B 48 8.959 25.265 3.525 1.00 1.00 H +ATOM 1540 H3' U B 48 6.586 25.699 1.723 1.00 1.00 H +ATOM 1541 H2' U B 48 5.126 24.713 3.224 1.00 1.00 H +ATOM 1542 HO2' U B 48 7.357 23.312 4.334 1.00 1.00 H +ATOM 1543 H1' U B 48 6.604 25.126 5.627 1.00 1.00 H +ATOM 1544 H3 U B 48 2.723 27.016 6.917 1.00 1.00 H +ATOM 1545 H5 U B 48 3.905 29.373 3.628 1.00 1.00 H +ATOM 1546 H6 U B 48 5.758 27.843 3.282 1.00 1.00 H +ATOM 1547 P A B 49 7.250 23.411 0.441 1.00 1.00 P +ATOM 1548 OP1 A B 49 7.979 24.157 -0.609 1.00 1.00 O +ATOM 1549 OP2 A B 49 5.770 23.380 0.432 1.00 1.00 O +ATOM 1550 O5' A B 49 7.787 21.894 0.448 1.00 1.00 O +ATOM 1551 C5' A B 49 8.960 21.551 1.189 1.00 1.00 C +ATOM 1552 C4' A B 49 8.645 20.560 2.307 1.00 1.00 C +ATOM 1553 O4' A B 49 7.385 20.896 2.893 1.00 1.00 O +ATOM 1554 C3' A B 49 8.569 19.101 1.845 1.00 1.00 C +ATOM 1555 O3' A B 49 9.453 18.305 2.641 1.00 1.00 O +ATOM 1556 C2' A B 49 7.129 18.675 2.109 1.00 1.00 C +ATOM 1557 O2' A B 49 7.069 17.349 2.648 1.00 1.00 O +ATOM 1558 C1' A B 49 6.636 19.703 3.114 1.00 1.00 C +ATOM 1559 N9 A B 49 5.201 20.037 2.992 1.00 1.00 N +ATOM 1560 C8 A B 49 4.498 20.422 1.880 1.00 1.00 C +ATOM 1561 N7 A B 49 3.233 20.651 2.108 1.00 1.00 N +ATOM 1562 C5 A B 49 3.092 20.397 3.470 1.00 1.00 C +ATOM 1563 C6 A B 49 1.988 20.457 4.337 1.00 1.00 C +ATOM 1564 N6 A B 49 0.764 20.809 3.940 1.00 1.00 N +ATOM 1565 N1 A B 49 2.200 20.141 5.626 1.00 1.00 N +ATOM 1566 C2 A B 49 3.420 19.792 6.016 1.00 1.00 C +ATOM 1567 N3 A B 49 4.531 19.700 5.301 1.00 1.00 N +ATOM 1568 C4 A B 49 4.286 20.023 4.015 1.00 1.00 C +ATOM 1569 H5' A B 49 9.385 22.455 1.625 1.00 1.00 H +ATOM 1570 H5'' A B 49 9.690 21.106 0.513 1.00 1.00 H +ATOM 1571 H4' A B 49 9.412 20.644 3.075 1.00 1.00 H +ATOM 1572 H3' A B 49 8.810 19.014 0.784 1.00 1.00 H +ATOM 1573 H2' A B 49 6.544 18.745 1.189 1.00 1.00 H +ATOM 1574 HO2' A B 49 6.371 16.882 2.182 1.00 1.00 H +ATOM 1575 H1' A B 49 6.833 19.340 4.122 1.00 1.00 H +ATOM 1576 H8 A B 49 4.953 20.527 0.894 1.00 1.00 H +ATOM 1577 H61 A B 49 0.014 20.834 4.606 1.00 1.00 H +ATOM 1578 H62 A B 49 0.591 21.048 2.977 1.00 1.00 H +ATOM 1579 H2 A B 49 3.521 19.546 7.073 1.00 1.00 H +ATOM 1580 P U B 50 9.612 16.729 2.354 1.00 1.00 P +ATOM 1581 OP1 U B 50 11.041 16.371 2.495 1.00 1.00 O +ATOM 1582 OP2 U B 50 8.892 16.414 1.099 1.00 1.00 O +ATOM 1583 O5' U B 50 8.806 16.064 3.577 1.00 1.00 O +ATOM 1584 C5' U B 50 9.509 15.469 4.669 1.00 1.00 C +ATOM 1585 C4' U B 50 8.774 15.676 5.990 1.00 1.00 C +ATOM 1586 O4' U B 50 9.061 16.985 6.492 1.00 1.00 O +ATOM 1587 C3' U B 50 7.252 15.542 5.878 1.00 1.00 C +ATOM 1588 O3' U B 50 6.779 14.558 6.801 1.00 1.00 O +ATOM 1589 C2' U B 50 6.710 16.904 6.282 1.00 1.00 C +ATOM 1590 O2' U B 50 5.561 16.784 7.126 1.00 1.00 O +ATOM 1591 C1' U B 50 7.867 17.550 7.025 1.00 1.00 C +ATOM 1592 N1 U B 50 7.935 19.018 6.874 1.00 1.00 N +ATOM 1593 C2 U B 50 9.180 19.609 6.957 1.00 1.00 C +ATOM 1594 O2 U B 50 10.203 18.954 7.144 1.00 1.00 O +ATOM 1595 N3 U B 50 9.211 20.985 6.820 1.00 1.00 N +ATOM 1596 C4 U B 50 8.118 21.809 6.609 1.00 1.00 C +ATOM 1597 O4 U B 50 8.261 23.025 6.500 1.00 1.00 O +ATOM 1598 C5 U B 50 6.857 21.106 6.536 1.00 1.00 C +ATOM 1599 C6 U B 50 6.803 19.758 6.668 1.00 1.00 C +ATOM 1600 H5' U B 50 10.503 15.914 4.739 1.00 1.00 H +ATOM 1601 H5'' U B 50 9.611 14.399 4.483 1.00 1.00 H +ATOM 1602 H4' U B 50 9.139 14.947 6.711 1.00 1.00 H +ATOM 1603 H3' U B 50 6.954 15.299 4.856 1.00 1.00 H +ATOM 1604 H2' U B 50 6.472 17.482 5.387 1.00 1.00 H +ATOM 1605 HO2' U B 50 5.877 16.729 8.031 1.00 1.00 H +ATOM 1606 H1' U B 50 7.795 17.303 8.084 1.00 1.00 H +ATOM 1607 H3 U B 50 10.115 21.431 6.879 1.00 1.00 H +ATOM 1608 H5 U B 50 5.938 21.667 6.373 1.00 1.00 H +ATOM 1609 H6 U B 50 5.837 19.255 6.610 1.00 1.00 H +ATOM 1610 P G B 51 5.453 13.708 6.467 1.00 1.00 P +ATOM 1611 OP1 G B 51 4.965 13.103 7.727 1.00 1.00 O +ATOM 1612 OP2 G B 51 5.732 12.848 5.295 1.00 1.00 O +ATOM 1613 O5' G B 51 4.405 14.845 6.019 1.00 1.00 O +ATOM 1614 C5' G B 51 3.471 15.388 6.956 1.00 1.00 C +ATOM 1615 C4' G B 51 2.092 15.548 6.330 1.00 1.00 C +ATOM 1616 O4' G B 51 2.032 16.768 5.591 1.00 1.00 O +ATOM 1617 C3' G B 51 1.735 14.428 5.374 1.00 1.00 C +ATOM 1618 O3' G B 51 0.984 13.429 6.071 1.00 1.00 O +ATOM 1619 C2' G B 51 0.865 15.100 4.324 1.00 1.00 C +ATOM 1620 O2' G B 51 -0.526 14.902 4.592 1.00 1.00 O +ATOM 1621 C1' G B 51 1.242 16.573 4.408 1.00 1.00 C +ATOM 1622 N9 G B 51 2.041 17.036 3.260 1.00 1.00 N +ATOM 1623 C8 G B 51 3.397 17.224 3.190 1.00 1.00 C +ATOM 1624 N7 G B 51 3.813 17.645 2.029 1.00 1.00 N +ATOM 1625 C5 G B 51 2.650 17.745 1.271 1.00 1.00 C +ATOM 1626 C6 G B 51 2.476 18.156 -0.080 1.00 1.00 C +ATOM 1627 O6 G B 51 3.333 18.517 -0.884 1.00 1.00 O +ATOM 1628 N1 G B 51 1.142 18.113 -0.457 1.00 1.00 N +ATOM 1629 C2 G B 51 0.100 17.726 0.360 1.00 1.00 C +ATOM 1630 N2 G B 51 -1.115 17.750 -0.184 1.00 1.00 N +ATOM 1631 N3 G B 51 0.261 17.339 1.630 1.00 1.00 N +ATOM 1632 C4 G B 51 1.559 17.373 2.016 1.00 1.00 C +ATOM 1633 H5' G B 51 3.826 16.361 7.289 1.00 1.00 H +ATOM 1634 H5'' G B 51 3.397 14.720 7.815 1.00 1.00 H +ATOM 1635 H4' G B 51 1.347 15.588 7.120 1.00 1.00 H +ATOM 1636 H3' G B 51 2.633 14.003 4.922 1.00 1.00 H +ATOM 1637 H2' G B 51 1.127 14.720 3.339 1.00 1.00 H +ATOM 1638 HO2' G B 51 -0.855 15.704 5.003 1.00 1.00 H +ATOM 1639 H1' G B 51 0.336 17.175 4.479 1.00 1.00 H +ATOM 1640 H8 G B 51 4.067 17.040 4.029 1.00 1.00 H +ATOM 1641 H1 G B 51 0.939 18.392 -1.405 1.00 1.00 H +ATOM 1642 H21 G B 51 -1.231 18.040 -1.139 1.00 1.00 H +ATOM 1643 H22 G B 51 -1.918 17.479 0.360 1.00 1.00 H +ATOM 1644 P G B 52 1.186 11.868 5.733 1.00 1.00 P +ATOM 1645 OP1 G B 52 0.442 11.075 6.737 1.00 1.00 O +ATOM 1646 OP2 G B 52 2.631 11.622 5.524 1.00 1.00 O +ATOM 1647 O5' G B 52 0.440 11.714 4.313 1.00 1.00 O +ATOM 1648 C5' G B 52 1.191 11.452 3.124 1.00 1.00 C +ATOM 1649 C4' G B 52 0.287 11.336 1.899 1.00 1.00 C +ATOM 1650 O4' G B 52 -0.016 12.640 1.399 1.00 1.00 O +ATOM 1651 C3' G B 52 0.904 10.550 0.752 1.00 1.00 C +ATOM 1652 O3' G B 52 0.494 9.180 0.830 1.00 1.00 O +ATOM 1653 C2' G B 52 0.314 11.199 -0.487 1.00 1.00 C +ATOM 1654 O2' G B 52 -0.892 10.546 -0.898 1.00 1.00 O +ATOM 1655 C1' G B 52 0.044 12.631 -0.036 1.00 1.00 C +ATOM 1656 N9 G B 52 1.089 13.590 -0.439 1.00 1.00 N +ATOM 1657 C8 G B 52 2.050 14.188 0.336 1.00 1.00 C +ATOM 1658 N7 G B 52 2.840 14.987 -0.326 1.00 1.00 N +ATOM 1659 C5 G B 52 2.371 14.914 -1.635 1.00 1.00 C +ATOM 1660 C6 G B 52 2.836 15.569 -2.808 1.00 1.00 C +ATOM 1661 O6 G B 52 3.773 16.357 -2.922 1.00 1.00 O +ATOM 1662 N1 G B 52 2.082 15.219 -3.920 1.00 1.00 N +ATOM 1663 C2 G B 52 1.013 14.348 -3.909 1.00 1.00 C +ATOM 1664 N2 G B 52 0.412 14.136 -5.079 1.00 1.00 N +ATOM 1665 N3 G B 52 0.575 13.730 -2.808 1.00 1.00 N +ATOM 1666 C4 G B 52 1.299 14.060 -1.713 1.00 1.00 C +ATOM 1667 H5' G B 52 1.742 10.520 3.248 1.00 1.00 H +ATOM 1668 H5'' G B 52 1.899 12.265 2.965 1.00 1.00 H +ATOM 1669 H4' G B 52 -0.644 10.856 2.192 1.00 1.00 H +ATOM 1670 H3' G B 52 1.992 10.639 0.759 1.00 1.00 H +ATOM 1671 H2' G B 52 1.049 11.198 -1.294 1.00 1.00 H +ATOM 1672 HO2' G B 52 -0.980 10.681 -1.845 1.00 1.00 H +ATOM 1673 H1' G B 52 -0.914 12.959 -0.436 1.00 1.00 H +ATOM 1674 H8 G B 52 2.144 14.015 1.408 1.00 1.00 H +ATOM 1675 H1 G B 52 2.353 15.647 -4.794 1.00 1.00 H +ATOM 1676 H21 G B 52 0.745 14.604 -5.911 1.00 1.00 H +ATOM 1677 H22 G B 52 -0.377 13.507 -5.136 1.00 1.00 H +ATOM 1678 P A B 53 1.514 7.994 0.441 1.00 1.00 P +ATOM 1679 OP1 A B 53 0.880 6.704 0.792 1.00 1.00 O +ATOM 1680 OP2 A B 53 2.847 8.334 0.987 1.00 1.00 O +ATOM 1681 O5' A B 53 1.590 8.096 -1.164 1.00 1.00 O +ATOM 1682 C5' A B 53 0.471 7.708 -1.966 1.00 1.00 C +ATOM 1683 C4' A B 53 0.702 8.018 -3.443 1.00 1.00 C +ATOM 1684 O4' A B 53 0.766 9.424 -3.652 1.00 1.00 O +ATOM 1685 C3' A B 53 1.990 7.446 -4.009 1.00 1.00 C +ATOM 1686 O3' A B 53 1.756 6.123 -4.506 1.00 1.00 O +ATOM 1687 C2' A B 53 2.322 8.385 -5.159 1.00 1.00 C +ATOM 1688 O2' A B 53 1.857 7.867 -6.409 1.00 1.00 O +ATOM 1689 C1' A B 53 1.601 9.682 -4.789 1.00 1.00 C +ATOM 1690 N9 A B 53 2.509 10.788 -4.443 1.00 1.00 N +ATOM 1691 C8 A B 53 3.089 11.087 -3.237 1.00 1.00 C +ATOM 1692 N7 A B 53 3.843 12.152 -3.264 1.00 1.00 N +ATOM 1693 C5 A B 53 3.755 12.589 -4.582 1.00 1.00 C +ATOM 1694 C6 A B 53 4.327 13.677 -5.262 1.00 1.00 C +ATOM 1695 N6 A B 53 5.136 14.560 -4.676 1.00 1.00 N +ATOM 1696 N1 A B 53 4.031 13.814 -6.565 1.00 1.00 N +ATOM 1697 C2 A B 53 3.224 12.932 -7.143 1.00 1.00 C +ATOM 1698 N3 A B 53 2.628 11.874 -6.614 1.00 1.00 N +ATOM 1699 C4 A B 53 2.945 11.763 -5.307 1.00 1.00 C +ATOM 1700 H5' A B 53 -0.411 8.245 -1.623 1.00 1.00 H +ATOM 1701 H5'' A B 53 0.304 6.637 -1.849 1.00 1.00 H +ATOM 1702 H4' A B 53 -0.136 7.627 -4.017 1.00 1.00 H +ATOM 1703 H3' A B 53 2.782 7.454 -3.258 1.00 1.00 H +ATOM 1704 H2' A B 53 3.400 8.561 -5.190 1.00 1.00 H +ATOM 1705 HO2' A B 53 1.123 8.416 -6.692 1.00 1.00 H +ATOM 1706 H1' A B 53 0.975 9.990 -5.626 1.00 1.00 H +ATOM 1707 H8 A B 53 2.936 10.489 -2.338 1.00 1.00 H +ATOM 1708 H61 A B 53 5.520 15.324 -5.212 1.00 1.00 H +ATOM 1709 H62 A B 53 5.365 14.466 -3.698 1.00 1.00 H +ATOM 1710 H2 A B 53 3.026 13.102 -8.202 1.00 1.00 H +ATOM 1711 P A B 54 2.984 5.106 -4.740 1.00 1.00 P +ATOM 1712 OP1 A B 54 2.460 3.723 -4.672 1.00 1.00 O +ATOM 1713 OP2 A B 54 4.098 5.517 -3.857 1.00 1.00 O +ATOM 1714 O5' A B 54 3.409 5.411 -6.265 1.00 1.00 O +ATOM 1715 C5' A B 54 2.535 5.078 -7.347 1.00 1.00 C +ATOM 1716 C4' A B 54 2.991 5.717 -8.657 1.00 1.00 C +ATOM 1717 O4' A B 54 3.123 7.129 -8.482 1.00 1.00 O +ATOM 1718 C3' A B 54 4.333 5.206 -9.161 1.00 1.00 C +ATOM 1719 O3' A B 54 4.124 4.115 -10.067 1.00 1.00 O +ATOM 1720 C2' A B 54 4.902 6.404 -9.906 1.00 1.00 C +ATOM 1721 O2' A B 54 4.513 6.401 -11.283 1.00 1.00 O +ATOM 1722 C1' A B 54 4.303 7.589 -9.158 1.00 1.00 C +ATOM 1723 N9 A B 54 5.204 8.157 -8.147 1.00 1.00 N +ATOM 1724 C8 A B 54 5.319 7.843 -6.816 1.00 1.00 C +ATOM 1725 N7 A B 54 6.242 8.521 -6.193 1.00 1.00 N +ATOM 1726 C5 A B 54 6.776 9.342 -7.181 1.00 1.00 C +ATOM 1727 C6 A B 54 7.800 10.304 -7.163 1.00 1.00 C +ATOM 1728 N6 A B 54 8.496 10.608 -6.067 1.00 1.00 N +ATOM 1729 N1 A B 54 8.073 10.934 -8.317 1.00 1.00 N +ATOM 1730 C2 A B 54 7.379 10.623 -9.406 1.00 1.00 C +ATOM 1731 N3 A B 54 6.401 9.741 -9.549 1.00 1.00 N +ATOM 1732 C4 A B 54 6.149 9.128 -8.374 1.00 1.00 C +ATOM 1733 H5' A B 54 1.530 5.427 -7.113 1.00 1.00 H +ATOM 1734 H5'' A B 54 2.516 3.995 -7.468 1.00 1.00 H +ATOM 1735 H4' A B 54 2.237 5.534 -9.420 1.00 1.00 H +ATOM 1736 H3' A B 54 4.979 4.918 -8.330 1.00 1.00 H +ATOM 1737 H2' A B 54 5.987 6.423 -9.810 1.00 1.00 H +ATOM 1738 HO2' A B 54 3.845 5.721 -11.390 1.00 1.00 H +ATOM 1739 H1' A B 54 4.034 8.368 -9.871 1.00 1.00 H +ATOM 1740 H8 A B 54 4.696 7.095 -6.325 1.00 1.00 H +ATOM 1741 H61 A B 54 9.226 11.312 -6.109 1.00 1.00 H +ATOM 1742 H62 A B 54 8.299 10.139 -5.196 1.00 1.00 H +ATOM 1743 H2 A B 54 7.652 11.169 -10.308 1.00 1.00 H +ATOM 1744 P G B 55 4.981 2.756 -9.926 1.00 1.00 P +ATOM 1745 OP1 G B 55 4.363 1.726 -10.789 1.00 1.00 O +ATOM 1746 OP2 G B 55 5.183 2.485 -8.484 1.00 1.00 O +ATOM 1747 O5' G B 55 6.404 3.159 -10.562 1.00 1.00 O +ATOM 1748 C5' G B 55 6.594 3.147 -11.980 1.00 1.00 C +ATOM 1749 C4' G B 55 7.943 3.742 -12.372 1.00 1.00 C +ATOM 1750 O4' G B 55 8.014 5.105 -11.961 1.00 1.00 O +ATOM 1751 C3' G B 55 9.141 3.048 -11.745 1.00 1.00 C +ATOM 1752 O3' G B 55 9.586 1.981 -12.593 1.00 1.00 O +ATOM 1753 C2' G B 55 10.195 4.141 -11.697 1.00 1.00 C +ATOM 1754 O2' G B 55 11.041 4.096 -12.852 1.00 1.00 O +ATOM 1755 C1' G B 55 9.380 5.425 -11.648 1.00 1.00 C +ATOM 1756 N9 G B 55 9.408 6.073 -10.325 1.00 1.00 N +ATOM 1757 C8 G B 55 8.564 5.898 -9.258 1.00 1.00 C +ATOM 1758 N7 G B 55 8.850 6.646 -8.230 1.00 1.00 N +ATOM 1759 C5 G B 55 9.965 7.370 -8.643 1.00 1.00 C +ATOM 1760 C6 G B 55 10.725 8.349 -7.945 1.00 1.00 C +ATOM 1761 O6 G B 55 10.556 8.778 -6.805 1.00 1.00 O +ATOM 1762 N1 G B 55 11.768 8.833 -8.721 1.00 1.00 N +ATOM 1763 C2 G B 55 12.050 8.427 -10.008 1.00 1.00 C +ATOM 1764 N2 G B 55 13.100 9.003 -10.591 1.00 1.00 N +ATOM 1765 N3 G B 55 11.336 7.508 -10.667 1.00 1.00 N +ATOM 1766 C4 G B 55 10.313 7.025 -9.925 1.00 1.00 C +ATOM 1767 H5' G B 55 5.800 3.727 -12.449 1.00 1.00 H +ATOM 1768 H5'' G B 55 6.542 2.119 -12.337 1.00 1.00 H +ATOM 1769 H4' G B 55 8.043 3.706 -13.455 1.00 1.00 H +ATOM 1770 H3' G B 55 8.904 2.689 -10.742 1.00 1.00 H +ATOM 1771 H2' G B 55 10.784 4.059 -10.781 1.00 1.00 H +ATOM 1772 HO2' G B 55 10.583 3.583 -13.520 1.00 1.00 H +ATOM 1773 H1' G B 55 9.764 6.121 -12.392 1.00 1.00 H +ATOM 1774 H8 G B 55 7.732 5.194 -9.268 1.00 1.00 H +ATOM 1775 H1 G B 55 12.353 9.534 -8.293 1.00 1.00 H +ATOM 1776 H21 G B 55 13.638 9.697 -10.090 1.00 1.00 H +ATOM 1777 H22 G B 55 13.359 8.747 -11.535 1.00 1.00 H +ATOM 1778 P A B 56 10.654 0.899 -12.055 1.00 1.00 P +ATOM 1779 OP1 A B 56 10.612 -0.281 -12.949 1.00 1.00 O +ATOM 1780 OP2 A B 56 10.447 0.727 -10.599 1.00 1.00 O +ATOM 1781 O5' A B 56 12.064 1.650 -12.280 1.00 1.00 O +ATOM 1782 C5' A B 56 12.577 1.856 -13.601 1.00 1.00 C +ATOM 1783 C4' A B 56 13.752 2.833 -13.606 1.00 1.00 C +ATOM 1784 O4' A B 56 13.387 4.037 -12.922 1.00 1.00 O +ATOM 1785 C3' A B 56 15.001 2.304 -12.918 1.00 1.00 C +ATOM 1786 O3' A B 56 15.841 1.637 -13.872 1.00 1.00 O +ATOM 1787 C2' A B 56 15.679 3.570 -12.418 1.00 1.00 C +ATOM 1788 O2' A B 56 16.585 4.100 -13.390 1.00 1.00 O +ATOM 1789 C1' A B 56 14.511 4.517 -12.161 1.00 1.00 C +ATOM 1790 N9 A B 56 14.109 4.571 -10.745 1.00 1.00 N +ATOM 1791 C8 A B 56 13.231 3.763 -10.069 1.00 1.00 C +ATOM 1792 N7 A B 56 13.090 4.075 -8.810 1.00 1.00 N +ATOM 1793 C5 A B 56 13.936 5.167 -8.641 1.00 1.00 C +ATOM 1794 C6 A B 56 14.245 5.966 -7.527 1.00 1.00 C +ATOM 1795 N6 A B 56 13.710 5.773 -6.321 1.00 1.00 N +ATOM 1796 N1 A B 56 15.126 6.965 -7.709 1.00 1.00 N +ATOM 1797 C2 A B 56 15.656 7.150 -8.912 1.00 1.00 C +ATOM 1798 N3 A B 56 15.448 6.471 -10.031 1.00 1.00 N +ATOM 1799 C4 A B 56 14.561 5.476 -9.816 1.00 1.00 C +ATOM 1800 H5' A B 56 11.783 2.248 -14.236 1.00 1.00 H +ATOM 1801 H5'' A B 56 12.911 0.898 -14.002 1.00 1.00 H +ATOM 1802 H4' A B 56 13.997 3.083 -14.637 1.00 1.00 H +ATOM 1803 H3' A B 56 14.740 1.647 -12.088 1.00 1.00 H +ATOM 1804 H2' A B 56 16.193 3.367 -11.484 1.00 1.00 H +ATOM 1805 HO2' A B 56 17.221 4.642 -12.917 1.00 1.00 H +ATOM 1806 H1' A B 56 14.772 5.525 -12.492 1.00 1.00 H +ATOM 1807 H8 A B 56 12.699 2.936 -10.539 1.00 1.00 H +ATOM 1808 H61 A B 56 13.966 6.380 -5.551 1.00 1.00 H +ATOM 1809 H62 A B 56 13.047 5.025 -6.175 1.00 1.00 H +ATOM 1810 H2 A B 56 16.362 7.976 -8.991 1.00 1.00 H +ATOM 1811 P A B 57 16.486 0.196 -13.531 1.00 1.00 P +ATOM 1812 OP1 A B 57 16.987 -0.396 -14.791 1.00 1.00 O +ATOM 1813 OP2 A B 57 15.520 -0.554 -12.699 1.00 1.00 O +ATOM 1814 O5' A B 57 17.758 0.570 -12.611 1.00 1.00 O +ATOM 1815 C5' A B 57 18.996 0.972 -13.208 1.00 1.00 C +ATOM 1816 C4' A B 57 20.000 1.447 -12.163 1.00 1.00 C +ATOM 1817 O4' A B 57 19.497 2.613 -11.508 1.00 1.00 O +ATOM 1818 C3' A B 57 20.291 0.427 -11.073 1.00 1.00 C +ATOM 1819 O3' A B 57 21.423 -0.372 -11.439 1.00 1.00 O +ATOM 1820 C2' A B 57 20.634 1.295 -9.876 1.00 1.00 C +ATOM 1821 O2' A B 57 22.031 1.600 -9.833 1.00 1.00 O +ATOM 1822 C1' A B 57 19.789 2.541 -10.105 1.00 1.00 C +ATOM 1823 N9 A B 57 18.503 2.513 -9.388 1.00 1.00 N +ATOM 1824 C8 A B 57 17.323 1.933 -9.777 1.00 1.00 C +ATOM 1825 N7 A B 57 16.348 2.099 -8.926 1.00 1.00 N +ATOM 1826 C5 A B 57 16.924 2.843 -7.901 1.00 1.00 C +ATOM 1827 C6 A B 57 16.414 3.349 -6.693 1.00 1.00 C +ATOM 1828 N6 A B 57 15.151 3.173 -6.303 1.00 1.00 N +ATOM 1829 N1 A B 57 17.258 4.041 -5.910 1.00 1.00 N +ATOM 1830 C2 A B 57 18.514 4.213 -6.304 1.00 1.00 C +ATOM 1831 N3 A B 57 19.109 3.790 -7.410 1.00 1.00 N +ATOM 1832 C4 A B 57 18.237 3.099 -8.174 1.00 1.00 C +ATOM 1833 H5' A B 57 18.805 1.784 -13.909 1.00 1.00 H +ATOM 1834 H5'' A B 57 19.420 0.128 -13.749 1.00 1.00 H +ATOM 1835 H4' A B 57 20.934 1.706 -12.661 1.00 1.00 H +ATOM 1836 H3' A B 57 19.414 -0.189 -10.870 1.00 1.00 H +ATOM 1837 H2' A B 57 20.320 0.804 -8.959 1.00 1.00 H +ATOM 1838 HO2' A B 57 22.129 2.524 -10.079 1.00 1.00 H +ATOM 1839 H1' A B 57 20.350 3.426 -9.803 1.00 1.00 H +ATOM 1840 H8 A B 57 17.211 1.380 -10.710 1.00 1.00 H +ATOM 1841 H61 A B 57 14.838 3.559 -5.424 1.00 1.00 H +ATOM 1842 H62 A B 57 14.511 2.654 -6.884 1.00 1.00 H +ATOM 1843 H2 A B 57 19.145 4.784 -5.622 1.00 1.00 H +ATOM 1844 P C B 58 21.486 -1.935 -11.049 1.00 1.00 P +ATOM 1845 OP1 C B 58 22.742 -2.498 -11.594 1.00 1.00 O +ATOM 1846 OP2 C B 58 20.189 -2.553 -11.406 1.00 1.00 O +ATOM 1847 O5' C B 58 21.605 -1.905 -9.443 1.00 1.00 O +ATOM 1848 C5' C B 58 22.870 -1.692 -8.811 1.00 1.00 C +ATOM 1849 C4' C B 58 22.719 -1.525 -7.301 1.00 1.00 C +ATOM 1850 O4' C B 58 21.925 -0.380 -7.018 1.00 1.00 O +ATOM 1851 C3' C B 58 22.035 -2.683 -6.603 1.00 1.00 C +ATOM 1852 O3' C B 58 22.996 -3.680 -6.242 1.00 1.00 O +ATOM 1853 C2' C B 58 21.454 -2.036 -5.353 1.00 1.00 C +ATOM 1854 O2' C B 58 22.358 -2.136 -4.248 1.00 1.00 O +ATOM 1855 C1' C B 58 21.236 -0.581 -5.770 1.00 1.00 C +ATOM 1856 N1 C B 58 19.814 -0.235 -5.986 1.00 1.00 N +ATOM 1857 C2 C B 58 19.144 0.430 -4.971 1.00 1.00 C +ATOM 1858 O2 C B 58 19.734 0.724 -3.934 1.00 1.00 O +ATOM 1859 N3 C B 58 17.832 0.743 -5.160 1.00 1.00 N +ATOM 1860 C4 C B 58 17.204 0.416 -6.299 1.00 1.00 C +ATOM 1861 N4 C B 58 15.919 0.734 -6.452 1.00 1.00 N +ATOM 1862 C5 C B 58 17.893 -0.267 -7.350 1.00 1.00 C +ATOM 1863 C6 C B 58 19.190 -0.572 -7.152 1.00 1.00 C +ATOM 1864 H5' C B 58 23.323 -0.791 -9.222 1.00 1.00 H +ATOM 1865 H5'' C B 58 23.518 -2.543 -9.013 1.00 1.00 H +ATOM 1866 H4' C B 58 23.704 -1.376 -6.860 1.00 1.00 H +ATOM 1867 H3' C B 58 21.245 -3.099 -7.230 1.00 1.00 H +ATOM 1868 H2' C B 58 20.498 -2.497 -5.112 1.00 1.00 H +ATOM 1869 HO2' C B 58 22.650 -1.248 -4.034 1.00 1.00 H +ATOM 1870 H1' C B 58 21.659 0.077 -5.014 1.00 1.00 H +ATOM 1871 H41 C B 58 15.427 1.216 -5.718 1.00 1.00 H +ATOM 1872 H42 C B 58 15.438 0.493 -7.306 1.00 1.00 H +ATOM 1873 H5 C B 58 17.388 -0.529 -8.279 1.00 1.00 H +ATOM 1874 H6 C B 58 19.748 -1.090 -7.932 1.00 1.00 H +ATOM 1875 P C B 59 22.527 -5.199 -5.981 1.00 1.00 P +ATOM 1876 OP1 C B 59 23.715 -5.993 -5.598 1.00 1.00 O +ATOM 1877 OP2 C B 59 21.686 -5.630 -7.121 1.00 1.00 O +ATOM 1878 O5' C B 59 21.583 -5.047 -4.686 1.00 1.00 O +ATOM 1879 C5' C B 59 22.137 -4.663 -3.426 1.00 1.00 C +ATOM 1880 C4' C B 59 21.074 -4.071 -2.502 1.00 1.00 C +ATOM 1881 O4' C B 59 20.344 -3.064 -3.194 1.00 1.00 O +ATOM 1882 C3' C B 59 20.035 -5.061 -2.002 1.00 1.00 C +ATOM 1883 O3' C B 59 20.477 -5.636 -0.769 1.00 1.00 O +ATOM 1884 C2' C B 59 18.809 -4.191 -1.743 1.00 1.00 C +ATOM 1885 O2' C B 59 18.703 -3.835 -0.361 1.00 1.00 O +ATOM 1886 C1' C B 59 19.030 -2.960 -2.619 1.00 1.00 C +ATOM 1887 N1 C B 59 18.037 -2.816 -3.712 1.00 1.00 N +ATOM 1888 C2 C B 59 16.983 -1.940 -3.500 1.00 1.00 C +ATOM 1889 O2 C B 59 16.890 -1.337 -2.433 1.00 1.00 O +ATOM 1890 N3 C B 59 16.067 -1.777 -4.493 1.00 1.00 N +ATOM 1891 C4 C B 59 16.179 -2.447 -5.648 1.00 1.00 C +ATOM 1892 N4 C B 59 15.265 -2.264 -6.600 1.00 1.00 N +ATOM 1893 C5 C B 59 17.264 -3.352 -5.873 1.00 1.00 C +ATOM 1894 C6 C B 59 18.166 -3.506 -4.883 1.00 1.00 C +ATOM 1895 H5' C B 59 22.919 -3.923 -3.590 1.00 1.00 H +ATOM 1896 H5'' C B 59 22.573 -5.542 -2.950 1.00 1.00 H +ATOM 1897 H4' C B 59 21.564 -3.611 -1.648 1.00 1.00 H +ATOM 1898 H3' C B 59 19.826 -5.826 -2.751 1.00 1.00 H +ATOM 1899 H2' C B 59 17.913 -4.718 -2.076 1.00 1.00 H +ATOM 1900 HO2' C B 59 18.481 -2.902 -0.323 1.00 1.00 H +ATOM 1901 H1' C B 59 19.000 -2.072 -1.988 1.00 1.00 H +ATOM 1902 H41 C B 59 14.489 -1.623 -6.444 1.00 1.00 H +ATOM 1903 H42 C B 59 15.339 -2.763 -7.474 1.00 1.00 H +ATOM 1904 H5 C B 59 17.359 -3.896 -6.813 1.00 1.00 H +ATOM 1905 H6 C B 59 19.005 -4.189 -5.019 1.00 1.00 H +ATOM 1906 P G B 60 19.664 -6.854 -0.103 1.00 1.00 P +ATOM 1907 OP1 G B 60 20.603 -7.638 0.729 1.00 1.00 O +ATOM 1908 OP2 G B 60 18.884 -7.525 -1.167 1.00 1.00 O +ATOM 1909 O5' G B 60 18.631 -6.101 0.881 1.00 1.00 O +ATOM 1910 C5' G B 60 19.094 -5.469 2.080 1.00 1.00 C +ATOM 1911 C4' G B 60 17.947 -4.834 2.862 1.00 1.00 C +ATOM 1912 O4' G B 60 17.280 -3.874 2.043 1.00 1.00 O +ATOM 1913 C3' G B 60 16.893 -5.826 3.329 1.00 1.00 C +ATOM 1914 O3' G B 60 17.183 -6.251 4.665 1.00 1.00 O +ATOM 1915 C2' G B 60 15.609 -5.018 3.318 1.00 1.00 C +ATOM 1916 O2' G B 60 15.352 -4.422 4.593 1.00 1.00 O +ATOM 1917 C1' G B 60 15.863 -3.964 2.252 1.00 1.00 C +ATOM 1918 N9 G B 60 15.250 -4.287 0.959 1.00 1.00 N +ATOM 1919 C8 G B 60 15.818 -4.895 -0.130 1.00 1.00 C +ATOM 1920 N7 G B 60 15.002 -5.048 -1.136 1.00 1.00 N +ATOM 1921 C5 G B 60 13.805 -4.502 -0.682 1.00 1.00 C +ATOM 1922 C6 G B 60 12.550 -4.384 -1.342 1.00 1.00 C +ATOM 1923 O6 G B 60 12.248 -4.747 -2.478 1.00 1.00 O +ATOM 1924 N1 G B 60 11.604 -3.772 -0.531 1.00 1.00 N +ATOM 1925 C2 G B 60 11.831 -3.329 0.754 1.00 1.00 C +ATOM 1926 N2 G B 60 10.795 -2.768 1.375 1.00 1.00 N +ATOM 1927 N3 G B 60 13.010 -3.438 1.376 1.00 1.00 N +ATOM 1928 C4 G B 60 13.946 -4.033 0.599 1.00 1.00 C +ATOM 1929 H5' G B 60 19.819 -4.698 1.822 1.00 1.00 H +ATOM 1930 H5'' G B 60 19.577 -6.216 2.708 1.00 1.00 H +ATOM 1931 H4' G B 60 18.356 -4.319 3.730 1.00 1.00 H +ATOM 1932 H3' G B 60 16.826 -6.674 2.647 1.00 1.00 H +ATOM 1933 H2' G B 60 14.777 -5.653 3.015 1.00 1.00 H +ATOM 1934 HO2' G B 60 14.584 -3.854 4.491 1.00 1.00 H +ATOM 1935 H1' G B 60 15.485 -3.003 2.597 1.00 1.00 H +ATOM 1936 H8 G B 60 16.857 -5.221 -0.153 1.00 1.00 H +ATOM 1937 H1 G B 60 10.684 -3.654 -0.934 1.00 1.00 H +ATOM 1938 H21 G B 60 9.906 -2.688 0.902 1.00 1.00 H +ATOM 1939 H22 G B 60 10.898 -2.424 2.319 1.00 1.00 H +ATOM 1940 P G B 61 16.541 -7.609 5.247 1.00 1.00 P +ATOM 1941 OP1 G B 61 16.987 -7.765 6.649 1.00 1.00 O +ATOM 1942 OP2 G B 61 16.784 -8.693 4.269 1.00 1.00 O +ATOM 1943 O5' G B 61 14.963 -7.280 5.255 1.00 1.00 O +ATOM 1944 C5' G B 61 14.433 -6.279 6.129 1.00 1.00 C +ATOM 1945 C4' G B 61 12.921 -6.133 5.965 1.00 1.00 C +ATOM 1946 O4' G B 61 12.614 -5.629 4.670 1.00 1.00 O +ATOM 1947 C3' G B 61 12.149 -7.431 6.114 1.00 1.00 C +ATOM 1948 O3' G B 61 11.784 -7.620 7.487 1.00 1.00 O +ATOM 1949 C2' G B 61 10.907 -7.211 5.265 1.00 1.00 C +ATOM 1950 O2' G B 61 9.797 -6.782 6.059 1.00 1.00 O +ATOM 1951 C1' G B 61 11.330 -6.134 4.266 1.00 1.00 C +ATOM 1952 N9 G B 61 11.463 -6.628 2.884 1.00 1.00 N +ATOM 1953 C8 G B 61 12.533 -7.248 2.294 1.00 1.00 C +ATOM 1954 N7 G B 61 12.338 -7.567 1.045 1.00 1.00 N +ATOM 1955 C5 G B 61 11.043 -7.127 0.783 1.00 1.00 C +ATOM 1956 C6 G B 61 10.280 -7.201 -0.415 1.00 1.00 C +ATOM 1957 O6 G B 61 10.606 -7.679 -1.499 1.00 1.00 O +ATOM 1958 N1 G B 61 9.021 -6.641 -0.252 1.00 1.00 N +ATOM 1959 C2 G B 61 8.549 -6.078 0.915 1.00 1.00 C +ATOM 1960 N2 G B 61 7.310 -5.591 0.876 1.00 1.00 N +ATOM 1961 N3 G B 61 9.265 -6.008 2.044 1.00 1.00 N +ATOM 1962 C4 G B 61 10.498 -6.551 1.904 1.00 1.00 C +ATOM 1963 H5' G B 61 14.908 -5.324 5.907 1.00 1.00 H +ATOM 1964 H5'' G B 61 14.652 -6.556 7.160 1.00 1.00 H +ATOM 1965 H4' G B 61 12.555 -5.421 6.703 1.00 1.00 H +ATOM 1966 H3' G B 61 12.733 -8.273 5.739 1.00 1.00 H +ATOM 1967 H2' G B 61 10.665 -8.128 4.729 1.00 1.00 H +ATOM 1968 HO2' G B 61 9.241 -6.234 5.501 1.00 1.00 H +ATOM 1969 H1' G B 61 10.603 -5.322 4.285 1.00 1.00 H +ATOM 1970 H8 G B 61 13.464 -7.454 2.820 1.00 1.00 H +ATOM 1971 H1 G B 61 8.419 -6.656 -1.063 1.00 1.00 H +ATOM 1972 H21 G B 61 6.773 -5.646 0.023 1.00 1.00 H +ATOM 1973 H22 G B 61 6.909 -5.166 1.699 1.00 1.00 H +ATOM 1974 P G B 62 11.437 -9.090 8.049 1.00 1.00 P +ATOM 1975 OP1 G B 62 11.284 -9.000 9.519 1.00 1.00 O +ATOM 1976 OP2 G B 62 12.404 -10.047 7.467 1.00 1.00 O +ATOM 1977 O5' G B 62 9.987 -9.386 7.409 1.00 1.00 O +ATOM 1978 C5' G B 62 8.844 -8.619 7.805 1.00 1.00 C +ATOM 1979 C4' G B 62 7.641 -8.900 6.907 1.00 1.00 C +ATOM 1980 O4' G B 62 7.946 -8.549 5.566 1.00 1.00 O +ATOM 1981 C3' G B 62 7.212 -10.354 6.876 1.00 1.00 C +ATOM 1982 O3' G B 62 6.255 -10.591 7.914 1.00 1.00 O +ATOM 1983 C2' G B 62 6.555 -10.505 5.508 1.00 1.00 C +ATOM 1984 O2' G B 62 5.133 -10.355 5.588 1.00 1.00 O +ATOM 1985 C1' G B 62 7.188 -9.384 4.674 1.00 1.00 C +ATOM 1986 N9 G B 62 8.115 -9.863 3.632 1.00 1.00 N +ATOM 1987 C8 G B 62 9.422 -10.254 3.763 1.00 1.00 C +ATOM 1988 N7 G B 62 9.974 -10.641 2.647 1.00 1.00 N +ATOM 1989 C5 G B 62 8.960 -10.494 1.704 1.00 1.00 C +ATOM 1990 C6 G B 62 8.970 -10.761 0.307 1.00 1.00 C +ATOM 1991 O6 G B 62 9.895 -11.185 -0.383 1.00 1.00 O +ATOM 1992 N1 G B 62 7.741 -10.478 -0.275 1.00 1.00 N +ATOM 1993 C2 G B 62 6.639 -10.000 0.401 1.00 1.00 C +ATOM 1994 N2 G B 62 5.544 -9.789 -0.330 1.00 1.00 N +ATOM 1995 N3 G B 62 6.626 -9.750 1.714 1.00 1.00 N +ATOM 1996 C4 G B 62 7.818 -10.019 2.298 1.00 1.00 C +ATOM 1997 H5' G B 62 9.089 -7.559 7.750 1.00 1.00 H +ATOM 1998 H5'' G B 62 8.587 -8.872 8.834 1.00 1.00 H +ATOM 1999 H4' G B 62 6.802 -8.292 7.238 1.00 1.00 H +ATOM 2000 H3' G B 62 8.074 -11.015 6.971 1.00 1.00 H +ATOM 2001 H2' G B 62 6.816 -11.477 5.079 1.00 1.00 H +ATOM 2002 HO2' G B 62 4.854 -9.858 4.817 1.00 1.00 H +ATOM 2003 H1' G B 62 6.402 -8.792 4.208 1.00 1.00 H +ATOM 2004 H8 G B 62 9.953 -10.243 4.715 1.00 1.00 H +ATOM 2005 H1 G B 62 7.672 -10.643 -1.269 1.00 1.00 H +ATOM 2006 H21 G B 62 5.556 -9.978 -1.321 1.00 1.00 H +ATOM 2007 H22 G B 62 4.704 -9.439 0.108 1.00 1.00 H +ATOM 2008 P G B 63 6.086 -12.060 8.552 1.00 1.00 P +ATOM 2009 OP1 G B 63 5.104 -11.975 9.658 1.00 1.00 O +ATOM 2010 OP2 G B 63 7.436 -12.610 8.806 1.00 1.00 O +ATOM 2011 O5' G B 63 5.419 -12.898 7.351 1.00 1.00 O +ATOM 2012 C5' G B 63 5.692 -14.294 7.209 1.00 1.00 C +ATOM 2013 C4' G B 63 5.234 -14.823 5.853 1.00 1.00 C +ATOM 2014 O4' G B 63 5.529 -13.863 4.835 1.00 1.00 O +ATOM 2015 C3' G B 63 5.887 -16.138 5.449 1.00 1.00 C +ATOM 2016 O3' G B 63 5.000 -17.221 5.747 1.00 1.00 O +ATOM 2017 C2' G B 63 6.057 -16.015 3.945 1.00 1.00 C +ATOM 2018 O2' G B 63 4.937 -16.569 3.251 1.00 1.00 O +ATOM 2019 C1' G B 63 6.154 -14.510 3.720 1.00 1.00 C +ATOM 2020 N9 G B 63 7.534 -14.003 3.639 1.00 1.00 N +ATOM 2021 C8 G B 63 8.329 -13.535 4.653 1.00 1.00 C +ATOM 2022 N7 G B 63 9.513 -13.155 4.266 1.00 1.00 N +ATOM 2023 C5 G B 63 9.507 -13.386 2.894 1.00 1.00 C +ATOM 2024 C6 G B 63 10.528 -13.163 1.930 1.00 1.00 C +ATOM 2025 O6 G B 63 11.658 -12.713 2.105 1.00 1.00 O +ATOM 2026 N1 G B 63 10.115 -13.530 0.656 1.00 1.00 N +ATOM 2027 C2 G B 63 8.876 -14.046 0.345 1.00 1.00 C +ATOM 2028 N2 G B 63 8.666 -14.337 -0.939 1.00 1.00 N +ATOM 2029 N3 G B 63 7.913 -14.257 1.249 1.00 1.00 N +ATOM 2030 C4 G B 63 8.298 -13.905 2.499 1.00 1.00 C +ATOM 2031 H5' G B 63 5.171 -14.838 7.996 1.00 1.00 H +ATOM 2032 H5'' G B 63 6.763 -14.460 7.315 1.00 1.00 H +ATOM 2033 H4' G B 63 4.155 -14.966 5.882 1.00 1.00 H +ATOM 2034 H3' G B 63 6.851 -16.267 5.941 1.00 1.00 H +ATOM 2035 H2' G B 63 6.986 -16.500 3.632 1.00 1.00 H +ATOM 2036 HO2' G B 63 5.117 -16.485 2.311 1.00 1.00 H +ATOM 2037 H1' G B 63 5.622 -14.249 2.808 1.00 1.00 H +ATOM 2038 H8 G B 63 7.999 -13.484 5.690 1.00 1.00 H +ATOM 2039 H1 G B 63 10.790 -13.400 -0.084 1.00 1.00 H +ATOM 2040 H21 G B 63 9.396 -14.175 -1.619 1.00 1.00 H +ATOM 2041 H22 G B 63 7.780 -14.717 -1.231 1.00 1.00 H +ATOM 2042 P A B 64 5.508 -18.473 6.623 1.00 1.00 P +ATOM 2043 OP1 A B 64 4.321 -19.211 7.109 1.00 1.00 O +ATOM 2044 OP2 A B 64 6.518 -17.981 7.587 1.00 1.00 O +ATOM 2045 O5' A B 64 6.258 -19.386 5.530 1.00 1.00 O +ATOM 2046 C5' A B 64 7.402 -20.164 5.891 1.00 1.00 C +ATOM 2047 C4' A B 64 7.770 -21.154 4.790 1.00 1.00 C +ATOM 2048 O4' A B 64 6.755 -22.162 4.701 1.00 1.00 O +ATOM 2049 C3' A B 64 7.910 -20.510 3.413 1.00 1.00 C +ATOM 2050 O3' A B 64 9.294 -20.429 3.058 1.00 1.00 O +ATOM 2051 C2' A B 64 7.201 -21.467 2.468 1.00 1.00 C +ATOM 2052 O2' A B 64 8.122 -22.362 1.841 1.00 1.00 O +ATOM 2053 C1' A B 64 6.234 -22.214 3.366 1.00 1.00 C +ATOM 2054 N9 A B 64 4.881 -21.630 3.393 1.00 1.00 N +ATOM 2055 C8 A B 64 4.300 -20.881 4.383 1.00 1.00 C +ATOM 2056 N7 A B 64 3.080 -20.507 4.116 1.00 1.00 N +ATOM 2057 C5 A B 64 2.834 -21.046 2.858 1.00 1.00 C +ATOM 2058 C6 A B 64 1.713 -21.007 2.013 1.00 1.00 C +ATOM 2059 N6 A B 64 0.585 -20.369 2.327 1.00 1.00 N +ATOM 2060 N1 A B 64 1.806 -21.648 0.836 1.00 1.00 N +ATOM 2061 C2 A B 64 2.932 -22.279 0.530 1.00 1.00 C +ATOM 2062 N3 A B 64 4.050 -22.387 1.234 1.00 1.00 N +ATOM 2063 C4 A B 64 3.925 -21.733 2.408 1.00 1.00 C +ATOM 2064 H5' A B 64 7.188 -20.715 6.807 1.00 1.00 H +ATOM 2065 H5'' A B 64 8.246 -19.497 6.065 1.00 1.00 H +ATOM 2066 H4' A B 64 8.713 -21.634 5.048 1.00 1.00 H +ATOM 2067 H3' A B 64 7.439 -19.526 3.394 1.00 1.00 H +ATOM 2068 H2' A B 64 6.642 -20.901 1.719 1.00 1.00 H +ATOM 2069 HO2' A B 64 7.642 -23.170 1.641 1.00 1.00 H +ATOM 2070 H1' A B 64 6.170 -23.252 3.045 1.00 1.00 H +ATOM 2071 H8 A B 64 4.811 -20.625 5.311 1.00 1.00 H +ATOM 2072 H61 A B 64 -0.192 -20.373 1.683 1.00 1.00 H +ATOM 2073 H62 A B 64 0.508 -19.884 3.210 1.00 1.00 H +ATOM 2074 H2 A B 64 2.939 -22.779 -0.440 1.00 1.00 H +ATOM 2075 P A B 65 9.823 -19.244 2.105 1.00 1.00 P +ATOM 2076 OP1 A B 65 11.279 -19.418 1.911 1.00 1.00 O +ATOM 2077 OP2 A B 65 9.295 -17.963 2.626 1.00 1.00 O +ATOM 2078 O5' A B 65 9.087 -19.564 0.710 1.00 1.00 O +ATOM 2079 C5' A B 65 9.369 -20.774 0.003 1.00 1.00 C +ATOM 2080 C4' A B 65 8.188 -21.194 -0.868 1.00 1.00 C +ATOM 2081 O4' A B 65 6.991 -21.135 -0.094 1.00 1.00 O +ATOM 2082 C3' A B 65 7.983 -20.321 -2.097 1.00 1.00 C +ATOM 2083 O3' A B 65 8.548 -20.973 -3.239 1.00 1.00 O +ATOM 2084 C2' A B 65 6.469 -20.231 -2.249 1.00 1.00 C +ATOM 2085 O2' A B 65 5.980 -21.192 -3.191 1.00 1.00 O +ATOM 2086 C1' A B 65 5.945 -20.512 -0.842 1.00 1.00 C +ATOM 2087 N9 A B 65 5.528 -19.301 -0.114 1.00 1.00 N +ATOM 2088 C8 A B 65 6.245 -18.536 0.770 1.00 1.00 C +ATOM 2089 N7 A B 65 5.584 -17.510 1.233 1.00 1.00 N +ATOM 2090 C5 A B 65 4.342 -17.606 0.611 1.00 1.00 C +ATOM 2091 C6 A B 65 3.181 -16.817 0.675 1.00 1.00 C +ATOM 2092 N6 A B 65 3.082 -15.725 1.434 1.00 1.00 N +ATOM 2093 N1 A B 65 2.132 -17.200 -0.073 1.00 1.00 N +ATOM 2094 C2 A B 65 2.238 -18.289 -0.826 1.00 1.00 C +ATOM 2095 N3 A B 65 3.267 -19.106 -0.972 1.00 1.00 N +ATOM 2096 C4 A B 65 4.302 -18.695 -0.210 1.00 1.00 C +ATOM 2097 H5' A B 65 9.583 -21.565 0.720 1.00 1.00 H +ATOM 2098 H5'' A B 65 10.244 -20.620 -0.630 1.00 1.00 H +ATOM 2099 H4' A B 65 8.338 -22.223 -1.190 1.00 1.00 H +ATOM 2100 H3' A B 65 8.419 -19.332 -1.949 1.00 1.00 H +ATOM 2101 H2' A B 65 6.189 -19.218 -2.553 1.00 1.00 H +ATOM 2102 HO2' A B 65 6.638 -21.887 -3.260 1.00 1.00 H +ATOM 2103 H1' A B 65 5.096 -21.195 -0.896 1.00 1.00 H +ATOM 2104 H8 A B 65 7.272 -18.762 1.059 1.00 1.00 H +ATOM 2105 H61 A B 65 2.222 -15.194 1.443 1.00 1.00 H +ATOM 2106 H62 A B 65 3.864 -15.429 1.999 1.00 1.00 H +ATOM 2107 H2 A B 65 1.350 -18.543 -1.407 1.00 1.00 H +ATOM 2108 P A B 66 9.017 -20.119 -4.521 1.00 1.00 P +ATOM 2109 OP1 A B 66 9.738 -21.026 -5.442 1.00 1.00 O +ATOM 2110 OP2 A B 66 9.672 -18.883 -4.039 1.00 1.00 O +ATOM 2111 O5' A B 66 7.616 -19.715 -5.203 1.00 1.00 O +ATOM 2112 C5' A B 66 7.461 -18.448 -5.847 1.00 1.00 C +ATOM 2113 C4' A B 66 5.988 -18.089 -6.035 1.00 1.00 C +ATOM 2114 O4' A B 66 5.287 -18.278 -4.802 1.00 1.00 O +ATOM 2115 C3' A B 66 5.753 -16.651 -6.473 1.00 1.00 C +ATOM 2116 O3' A B 66 5.601 -16.597 -7.896 1.00 1.00 O +ATOM 2117 C2' A B 66 4.440 -16.278 -5.803 1.00 1.00 C +ATOM 2118 O2' A B 66 3.324 -16.544 -6.657 1.00 1.00 O +ATOM 2119 C1' A B 66 4.414 -17.163 -4.565 1.00 1.00 C +ATOM 2120 N9 A B 66 4.884 -16.481 -3.346 1.00 1.00 N +ATOM 2121 C8 A B 66 6.158 -16.414 -2.843 1.00 1.00 C +ATOM 2122 N7 A B 66 6.257 -15.708 -1.750 1.00 1.00 N +ATOM 2123 C5 A B 66 4.955 -15.278 -1.513 1.00 1.00 C +ATOM 2124 C6 A B 66 4.386 -14.487 -0.502 1.00 1.00 C +ATOM 2125 N6 A B 66 5.093 -13.961 0.499 1.00 1.00 N +ATOM 2126 N1 A B 66 3.065 -14.258 -0.569 1.00 1.00 N +ATOM 2127 C2 A B 66 2.367 -14.780 -1.570 1.00 1.00 C +ATOM 2128 N3 A B 66 2.785 -15.534 -2.576 1.00 1.00 N +ATOM 2129 C4 A B 66 4.113 -15.746 -2.480 1.00 1.00 C +ATOM 2130 H5' A B 66 7.946 -18.482 -6.822 1.00 1.00 H +ATOM 2131 H5'' A B 66 7.939 -17.680 -5.239 1.00 1.00 H +ATOM 2132 H4' A B 66 5.558 -18.756 -6.780 1.00 1.00 H +ATOM 2133 H3' A B 66 6.563 -16.001 -6.135 1.00 1.00 H +ATOM 2134 H2' A B 66 4.455 -15.229 -5.501 1.00 1.00 H +ATOM 2135 HO2' A B 66 2.657 -15.878 -6.468 1.00 1.00 H +ATOM 2136 H1' A B 66 3.400 -17.528 -4.402 1.00 1.00 H +ATOM 2137 H8 A B 66 7.011 -16.905 -3.313 1.00 1.00 H +ATOM 2138 H61 A B 66 4.632 -13.398 1.201 1.00 1.00 H +ATOM 2139 H62 A B 66 6.093 -14.127 0.561 1.00 1.00 H +ATOM 2140 H2 A B 66 1.301 -14.554 -1.564 1.00 1.00 H +ATOM 2141 P C B 67 6.285 -15.414 -8.747 1.00 1.00 P +ATOM 2142 OP1 C B 67 5.907 -15.583 -10.168 1.00 1.00 O +ATOM 2143 OP2 C B 67 7.714 -15.339 -8.369 1.00 1.00 O +ATOM 2144 O5' C B 67 5.544 -14.101 -8.181 1.00 1.00 O +ATOM 2145 C5' C B 67 4.120 -13.993 -8.228 1.00 1.00 C +ATOM 2146 C4' C B 67 3.588 -13.110 -7.102 1.00 1.00 C +ATOM 2147 O4' C B 67 4.089 -13.569 -5.849 1.00 1.00 O +ATOM 2148 C3' C B 67 3.984 -11.648 -7.213 1.00 1.00 C +ATOM 2149 O3' C B 67 2.990 -10.932 -7.953 1.00 1.00 O +ATOM 2150 C2' C B 67 3.996 -11.173 -5.770 1.00 1.00 C +ATOM 2151 O2' C B 67 2.739 -10.602 -5.395 1.00 1.00 O +ATOM 2152 C1' C B 67 4.288 -12.443 -4.976 1.00 1.00 C +ATOM 2153 N1 C B 67 5.669 -12.515 -4.462 1.00 1.00 N +ATOM 2154 C2 C B 67 5.933 -11.891 -3.252 1.00 1.00 C +ATOM 2155 O2 C B 67 5.035 -11.305 -2.652 1.00 1.00 O +ATOM 2156 N3 C B 67 7.202 -11.946 -2.762 1.00 1.00 N +ATOM 2157 C4 C B 67 8.171 -12.587 -3.430 1.00 1.00 C +ATOM 2158 N4 C B 67 9.403 -12.623 -2.921 1.00 1.00 N +ATOM 2159 C5 C B 67 7.901 -13.232 -4.678 1.00 1.00 C +ATOM 2160 C6 C B 67 6.643 -13.172 -5.155 1.00 1.00 C +ATOM 2161 H5' C B 67 3.684 -14.988 -8.137 1.00 1.00 H +ATOM 2162 H5'' C B 67 3.828 -13.562 -9.186 1.00 1.00 H +ATOM 2163 H4' C B 67 2.502 -13.181 -7.084 1.00 1.00 H +ATOM 2164 H3' C B 67 4.971 -11.545 -7.666 1.00 1.00 H +ATOM 2165 H2' C B 67 4.805 -10.454 -5.622 1.00 1.00 H +ATOM 2166 HO2' C B 67 2.873 -10.134 -4.567 1.00 1.00 H +ATOM 2167 H1' C B 67 3.594 -12.510 -4.140 1.00 1.00 H +ATOM 2168 H41 C B 67 9.599 -12.169 -2.040 1.00 1.00 H +ATOM 2169 H42 C B 67 10.140 -13.104 -3.417 1.00 1.00 H +ATOM 2170 H5 C B 67 8.687 -13.754 -5.225 1.00 1.00 H +ATOM 2171 H6 C B 67 6.400 -13.654 -6.102 1.00 1.00 H +ATOM 2172 P U B 68 3.352 -9.539 -8.676 1.00 1.00 P +ATOM 2173 OP1 U B 68 2.160 -9.081 -9.424 1.00 1.00 O +ATOM 2174 OP2 U B 68 4.646 -9.703 -9.376 1.00 1.00 O +ATOM 2175 O5' U B 68 3.578 -8.546 -7.428 1.00 1.00 O +ATOM 2176 C5' U B 68 2.512 -8.273 -6.515 1.00 1.00 C +ATOM 2177 C4' U B 68 2.999 -7.479 -5.307 1.00 1.00 C +ATOM 2178 O4' U B 68 3.979 -8.227 -4.595 1.00 1.00 O +ATOM 2179 C3' U B 68 3.644 -6.149 -5.649 1.00 1.00 C +ATOM 2180 O3' U B 68 2.650 -5.120 -5.671 1.00 1.00 O +ATOM 2181 C2' U B 68 4.601 -5.913 -4.494 1.00 1.00 C +ATOM 2182 O2' U B 68 4.003 -5.093 -3.490 1.00 1.00 O +ATOM 2183 C1' U B 68 4.886 -7.314 -3.958 1.00 1.00 C +ATOM 2184 N1 U B 68 6.260 -7.783 -4.226 1.00 1.00 N +ATOM 2185 C2 U B 68 7.207 -7.605 -3.234 1.00 1.00 C +ATOM 2186 O2 U B 68 6.935 -7.074 -2.159 1.00 1.00 O +ATOM 2187 N3 U B 68 8.482 -8.058 -3.523 1.00 1.00 N +ATOM 2188 C4 U B 68 8.887 -8.666 -4.699 1.00 1.00 C +ATOM 2189 O4 U B 68 10.051 -9.031 -4.848 1.00 1.00 O +ATOM 2190 C5 U B 68 7.832 -8.812 -5.678 1.00 1.00 C +ATOM 2191 C6 U B 68 6.576 -8.375 -5.420 1.00 1.00 C +ATOM 2192 H5' U B 68 2.087 -9.216 -6.172 1.00 1.00 H +ATOM 2193 H5'' U B 68 1.741 -7.701 -7.030 1.00 1.00 H +ATOM 2194 H4' U B 68 2.159 -7.299 -4.643 1.00 1.00 H +ATOM 2195 H3' U B 68 4.180 -6.207 -6.598 1.00 1.00 H +ATOM 2196 H2' U B 68 5.522 -5.460 -4.861 1.00 1.00 H +ATOM 2197 HO2' U B 68 4.501 -5.231 -2.680 1.00 1.00 H +ATOM 2198 H1' U B 68 4.704 -7.328 -2.882 1.00 1.00 H +ATOM 2199 H3 U B 68 9.184 -7.934 -2.807 1.00 1.00 H +ATOM 2200 H5 U B 68 8.053 -9.278 -6.638 1.00 1.00 H +ATOM 2201 H6 U B 68 5.802 -8.496 -6.176 1.00 1.00 H +ATOM 2202 P U B 69 3.014 -3.647 -6.211 1.00 1.00 P +ATOM 2203 OP1 U B 69 1.752 -2.898 -6.400 1.00 1.00 O +ATOM 2204 OP2 U B 69 3.963 -3.793 -7.338 1.00 1.00 O +ATOM 2205 O5' U B 69 3.805 -2.995 -4.967 1.00 1.00 O +ATOM 2206 C5' U B 69 3.118 -2.672 -3.754 1.00 1.00 C +ATOM 2207 C4' U B 69 4.093 -2.307 -2.640 1.00 1.00 C +ATOM 2208 O4' U B 69 5.022 -3.370 -2.444 1.00 1.00 O +ATOM 2209 C3' U B 69 4.923 -1.069 -2.917 1.00 1.00 C +ATOM 2210 O3' U B 69 4.238 0.101 -2.441 1.00 1.00 O +ATOM 2211 C2' U B 69 6.185 -1.315 -2.104 1.00 1.00 C +ATOM 2212 O2' U B 69 6.083 -0.764 -0.790 1.00 1.00 O +ATOM 2213 C1' U B 69 6.294 -2.832 -2.048 1.00 1.00 C +ATOM 2214 N1 U B 69 7.318 -3.375 -2.967 1.00 1.00 N +ATOM 2215 C2 U B 69 8.555 -3.705 -2.447 1.00 1.00 C +ATOM 2216 O2 U B 69 8.824 -3.561 -1.256 1.00 1.00 O +ATOM 2217 N3 U B 69 9.479 -4.204 -3.348 1.00 1.00 N +ATOM 2218 C4 U B 69 9.273 -4.400 -4.703 1.00 1.00 C +ATOM 2219 O4 U B 69 10.168 -4.854 -5.414 1.00 1.00 O +ATOM 2220 C5 U B 69 7.951 -4.030 -5.157 1.00 1.00 C +ATOM 2221 C6 U B 69 7.031 -3.539 -4.293 1.00 1.00 C +ATOM 2222 H5' U B 69 2.525 -3.530 -3.440 1.00 1.00 H +ATOM 2223 H5'' U B 69 2.454 -1.827 -3.937 1.00 1.00 H +ATOM 2224 H4' U B 69 3.539 -2.161 -1.716 1.00 1.00 H +ATOM 2225 H3' U B 69 5.154 -0.988 -3.980 1.00 1.00 H +ATOM 2226 H2' U B 69 7.046 -0.912 -2.633 1.00 1.00 H +ATOM 2227 HO2' U B 69 5.964 -1.494 -0.182 1.00 1.00 H +ATOM 2228 H1' U B 69 6.514 -3.141 -1.026 1.00 1.00 H +ATOM 2229 H3 U B 69 10.389 -4.449 -2.983 1.00 1.00 H +ATOM 2230 H5 U B 69 7.693 -4.144 -6.211 1.00 1.00 H +ATOM 2231 H6 U B 69 6.042 -3.270 -4.663 1.00 1.00 H +ATOM 2232 P G B 70 4.662 1.568 -2.962 1.00 1.00 P +ATOM 2233 OP1 G B 70 3.695 2.556 -2.427 1.00 1.00 O +ATOM 2234 OP2 G B 70 4.908 1.493 -4.419 1.00 1.00 O +ATOM 2235 O5' G B 70 6.074 1.792 -2.224 1.00 1.00 O +ATOM 2236 C5' G B 70 6.151 1.733 -0.799 1.00 1.00 C +ATOM 2237 C4' G B 70 7.567 1.414 -0.329 1.00 1.00 C +ATOM 2238 O4' G B 70 8.078 0.298 -1.060 1.00 1.00 O +ATOM 2239 C3' G B 70 8.568 2.535 -0.530 1.00 1.00 C +ATOM 2240 O3' G B 70 8.597 3.355 0.646 1.00 1.00 O +ATOM 2241 C2' G B 70 9.895 1.803 -0.666 1.00 1.00 C +ATOM 2242 O2' G B 70 10.611 1.793 0.576 1.00 1.00 O +ATOM 2243 C1' G B 70 9.505 0.395 -1.100 1.00 1.00 C +ATOM 2244 N9 G B 70 9.999 0.025 -2.441 1.00 1.00 N +ATOM 2245 C8 G B 70 9.375 0.099 -3.661 1.00 1.00 C +ATOM 2246 N7 G B 70 10.091 -0.363 -4.649 1.00 1.00 N +ATOM 2247 C5 G B 70 11.276 -0.769 -4.041 1.00 1.00 C +ATOM 2248 C6 G B 70 12.441 -1.354 -4.612 1.00 1.00 C +ATOM 2249 O6 G B 70 12.653 -1.638 -5.788 1.00 1.00 O +ATOM 2250 N1 G B 70 13.408 -1.605 -3.648 1.00 1.00 N +ATOM 2251 C2 G B 70 13.273 -1.332 -2.303 1.00 1.00 C +ATOM 2252 N2 G B 70 14.313 -1.639 -1.529 1.00 1.00 N +ATOM 2253 N3 G B 70 12.180 -0.786 -1.766 1.00 1.00 N +ATOM 2254 C4 G B 70 11.228 -0.531 -2.691 1.00 1.00 C +ATOM 2255 H5' G B 70 5.472 0.964 -0.433 1.00 1.00 H +ATOM 2256 H5'' G B 70 5.852 2.697 -0.391 1.00 1.00 H +ATOM 2257 H4' G B 70 7.543 1.150 0.726 1.00 1.00 H +ATOM 2258 H3' G B 70 8.341 3.119 -1.423 1.00 1.00 H +ATOM 2259 H2' G B 70 10.495 2.275 -1.447 1.00 1.00 H +ATOM 2260 HO2' G B 70 10.504 0.924 0.965 1.00 1.00 H +ATOM 2261 H1' G B 70 9.908 -0.321 -0.383 1.00 1.00 H +ATOM 2262 H8 G B 70 8.374 0.510 -3.795 1.00 1.00 H +ATOM 2263 H1 G B 70 14.265 -2.025 -3.978 1.00 1.00 H +ATOM 2264 H21 G B 70 15.144 -2.051 -1.935 1.00 1.00 H +ATOM 2265 H22 G B 70 14.271 -1.459 -0.536 1.00 1.00 H +ATOM 2266 P G B 71 9.378 4.763 0.646 1.00 1.00 P +ATOM 2267 OP1 G B 71 8.788 5.620 1.699 1.00 1.00 O +ATOM 2268 OP2 G B 71 9.445 5.252 -0.749 1.00 1.00 O +ATOM 2269 O5' G B 71 10.866 4.352 1.110 1.00 1.00 O +ATOM 2270 C5' G B 71 11.173 4.139 2.493 1.00 1.00 C +ATOM 2271 C4' G B 71 12.672 4.258 2.756 1.00 1.00 C +ATOM 2272 O4' G B 71 13.323 3.023 2.443 1.00 1.00 O +ATOM 2273 C3' G B 71 13.347 5.347 1.935 1.00 1.00 C +ATOM 2274 O3' G B 71 13.466 6.538 2.720 1.00 1.00 O +ATOM 2275 C2' G B 71 14.722 4.777 1.636 1.00 1.00 C +ATOM 2276 O2' G B 71 15.675 5.146 2.636 1.00 1.00 O +ATOM 2277 C1' G B 71 14.477 3.278 1.629 1.00 1.00 C +ATOM 2278 N9 G B 71 14.188 2.740 0.297 1.00 1.00 N +ATOM 2279 C8 G B 71 12.963 2.465 -0.254 1.00 1.00 C +ATOM 2280 N7 G B 71 13.022 1.997 -1.468 1.00 1.00 N +ATOM 2281 C5 G B 71 14.384 1.956 -1.746 1.00 1.00 C +ATOM 2282 C6 G B 71 15.058 1.532 -2.924 1.00 1.00 C +ATOM 2283 O6 G B 71 14.572 1.104 -3.969 1.00 1.00 O +ATOM 2284 N1 G B 71 16.434 1.649 -2.793 1.00 1.00 N +ATOM 2285 C2 G B 71 17.085 2.116 -1.671 1.00 1.00 C +ATOM 2286 N2 G B 71 18.416 2.156 -1.738 1.00 1.00 N +ATOM 2287 N3 G B 71 16.454 2.517 -0.561 1.00 1.00 N +ATOM 2288 C4 G B 71 15.108 2.409 -0.671 1.00 1.00 C +ATOM 2289 H5' G B 71 10.840 3.142 2.783 1.00 1.00 H +ATOM 2290 H5'' G B 71 10.648 4.880 3.094 1.00 1.00 H +ATOM 2291 H4' G B 71 12.827 4.469 3.814 1.00 1.00 H +ATOM 2292 H3' G B 71 12.795 5.532 1.014 1.00 1.00 H +ATOM 2293 H2' G B 71 15.051 5.101 0.648 1.00 1.00 H +ATOM 2294 HO2' G B 71 15.452 4.660 3.432 1.00 1.00 H +ATOM 2295 H1' G B 71 15.341 2.765 2.047 1.00 1.00 H +ATOM 2296 H8 G B 71 12.024 2.620 0.277 1.00 1.00 H +ATOM 2297 H1 G B 71 16.981 1.366 -3.592 1.00 1.00 H +ATOM 2298 H21 G B 71 18.891 1.851 -2.582 1.00 1.00 H +ATOM 2299 H22 G B 71 18.949 2.489 -0.947 1.00 1.00 H +ATOM 2300 P U B 72 13.507 7.985 2.015 1.00 1.00 P +ATOM 2301 OP1 U B 72 13.420 9.018 3.070 1.00 1.00 O +ATOM 2302 OP2 U B 72 12.532 7.985 0.901 1.00 1.00 O +ATOM 2303 O5' U B 72 14.988 8.037 1.383 1.00 1.00 O +ATOM 2304 C5' U B 72 16.126 8.274 2.216 1.00 1.00 C +ATOM 2305 C4' U B 72 17.419 8.301 1.405 1.00 1.00 C +ATOM 2306 O4' U B 72 17.605 7.041 0.765 1.00 1.00 O +ATOM 2307 C3' U B 72 17.442 9.355 0.312 1.00 1.00 C +ATOM 2308 O3' U B 72 18.033 10.556 0.820 1.00 1.00 O +ATOM 2309 C2' U B 72 18.341 8.737 -0.751 1.00 1.00 C +ATOM 2310 O2' U B 72 19.711 9.099 -0.552 1.00 1.00 O +ATOM 2311 C1' U B 72 18.130 7.236 -0.559 1.00 1.00 C +ATOM 2312 N1 U B 72 17.158 6.647 -1.505 1.00 1.00 N +ATOM 2313 C2 U B 72 17.647 6.083 -2.669 1.00 1.00 C +ATOM 2314 O2 U B 72 18.850 6.056 -2.927 1.00 1.00 O +ATOM 2315 N3 U B 72 16.705 5.549 -3.528 1.00 1.00 N +ATOM 2316 C4 U B 72 15.335 5.531 -3.329 1.00 1.00 C +ATOM 2317 O4 U B 72 14.588 5.027 -4.164 1.00 1.00 O +ATOM 2318 C5 U B 72 14.913 6.141 -2.088 1.00 1.00 C +ATOM 2319 C6 U B 72 15.818 6.671 -1.229 1.00 1.00 C +ATOM 2320 H5' U B 72 16.192 7.485 2.965 1.00 1.00 H +ATOM 2321 H5'' U B 72 16.002 9.233 2.721 1.00 1.00 H +ATOM 2322 H4' U B 72 18.257 8.473 2.079 1.00 1.00 H +ATOM 2323 H3' U B 72 16.439 9.535 -0.076 1.00 1.00 H +ATOM 2324 H2' U B 72 18.002 9.033 -1.744 1.00 1.00 H +ATOM 2325 HO2' U B 72 20.213 8.285 -0.465 1.00 1.00 H +ATOM 2326 H1' U B 72 19.086 6.721 -0.648 1.00 1.00 H +ATOM 2327 H3 U B 72 17.049 5.134 -4.382 1.00 1.00 H +ATOM 2328 H5 U B 72 13.852 6.176 -1.840 1.00 1.00 H +ATOM 2329 H6 U B 72 15.471 7.125 -0.302 1.00 1.00 H +ATOM 2330 P U B 73 17.456 11.996 0.387 1.00 1.00 P +ATOM 2331 OP1 U B 73 18.221 13.038 1.107 1.00 1.00 O +ATOM 2332 OP2 U B 73 15.980 11.954 0.500 1.00 1.00 O +ATOM 2333 O5' U B 73 17.837 12.077 -1.176 1.00 1.00 O +ATOM 2334 C5' U B 73 19.160 12.434 -1.587 1.00 1.00 C +ATOM 2335 C4' U B 73 19.287 12.446 -3.108 1.00 1.00 C +ATOM 2336 O4' U B 73 19.113 11.125 -3.622 1.00 1.00 O +ATOM 2337 C3' U B 73 18.257 13.315 -3.807 1.00 1.00 C +ATOM 2338 O3' U B 73 18.753 14.653 -3.945 1.00 1.00 O +ATOM 2339 C2' U B 73 18.126 12.660 -5.172 1.00 1.00 C +ATOM 2340 O2' U B 73 19.056 13.208 -6.110 1.00 1.00 O +ATOM 2341 C1' U B 73 18.422 11.192 -4.883 1.00 1.00 C +ATOM 2342 N1 U B 73 17.210 10.363 -4.761 1.00 1.00 N +ATOM 2343 C2 U B 73 16.754 9.706 -5.889 1.00 1.00 C +ATOM 2344 O2 U B 73 17.315 9.809 -6.978 1.00 1.00 O +ATOM 2345 N3 U B 73 15.622 8.927 -5.722 1.00 1.00 N +ATOM 2346 C4 U B 73 14.919 8.750 -4.543 1.00 1.00 C +ATOM 2347 O4 U B 73 13.925 8.028 -4.509 1.00 1.00 O +ATOM 2348 C5 U B 73 15.466 9.474 -3.417 1.00 1.00 C +ATOM 2349 C6 U B 73 16.573 10.243 -3.556 1.00 1.00 C +ATOM 2350 H5' U B 73 19.868 11.715 -1.178 1.00 1.00 H +ATOM 2351 H5'' U B 73 19.396 13.426 -1.202 1.00 1.00 H +ATOM 2352 H4' U B 73 20.283 12.792 -3.377 1.00 1.00 H +ATOM 2353 H3' U B 73 17.306 13.296 -3.274 1.00 1.00 H +ATOM 2354 H2' U B 73 17.104 12.763 -5.535 1.00 1.00 H +ATOM 2355 HO2' U B 73 19.768 12.572 -6.208 1.00 1.00 H +ATOM 2356 H1' U B 73 19.064 10.787 -5.668 1.00 1.00 H +ATOM 2357 H3 U B 73 15.278 8.441 -6.539 1.00 1.00 H +ATOM 2358 H5 U B 73 14.982 9.399 -2.445 1.00 1.00 H +ATOM 2359 H6 U B 73 16.962 10.779 -2.691 1.00 1.00 H +ATOM 2360 P C B 74 17.729 15.896 -4.011 1.00 1.00 P +ATOM 2361 OP1 C B 74 18.519 17.144 -4.119 1.00 1.00 O +ATOM 2362 OP2 C B 74 16.742 15.744 -2.918 1.00 1.00 O +ATOM 2363 O5' C B 74 16.966 15.659 -5.411 1.00 1.00 O +ATOM 2364 C5' C B 74 17.636 15.891 -6.652 1.00 1.00 C +ATOM 2365 C4' C B 74 16.882 15.268 -7.824 1.00 1.00 C +ATOM 2366 O4' C B 74 16.657 13.882 -7.587 1.00 1.00 O +ATOM 2367 C3' C B 74 15.517 15.871 -8.077 1.00 1.00 C +ATOM 2368 O3' C B 74 15.647 17.025 -8.917 1.00 1.00 O +ATOM 2369 C2' C B 74 14.787 14.755 -8.808 1.00 1.00 C +ATOM 2370 O2' C B 74 14.889 14.905 -10.228 1.00 1.00 O +ATOM 2371 C1' C B 74 15.485 13.483 -8.321 1.00 1.00 C +ATOM 2372 N1 C B 74 14.643 12.658 -7.426 1.00 1.00 N +ATOM 2373 C2 C B 74 13.948 11.602 -7.995 1.00 1.00 C +ATOM 2374 O2 C B 74 14.034 11.388 -9.202 1.00 1.00 O +ATOM 2375 N3 C B 74 13.175 10.827 -7.185 1.00 1.00 N +ATOM 2376 C4 C B 74 13.087 11.078 -5.871 1.00 1.00 C +ATOM 2377 N4 C B 74 12.322 10.298 -5.106 1.00 1.00 N +ATOM 2378 C5 C B 74 13.803 12.167 -5.280 1.00 1.00 C +ATOM 2379 C6 C B 74 14.566 12.927 -6.091 1.00 1.00 C +ATOM 2380 H5' C B 74 18.635 15.461 -6.605 1.00 1.00 H +ATOM 2381 H5'' C B 74 17.718 16.966 -6.815 1.00 1.00 H +ATOM 2382 H4' C B 74 17.480 15.368 -8.725 1.00 1.00 H +ATOM 2383 H3' C B 74 15.020 16.117 -7.136 1.00 1.00 H +ATOM 2384 H2' C B 74 13.752 14.736 -8.498 1.00 1.00 H +ATOM 2385 HO2' C B 74 15.580 14.315 -10.533 1.00 1.00 H +ATOM 2386 H1' C B 74 15.793 12.883 -9.180 1.00 1.00 H +ATOM 2387 H41 C B 74 11.814 9.528 -5.519 1.00 1.00 H +ATOM 2388 H42 C B 74 12.249 10.477 -4.116 1.00 1.00 H +ATOM 2389 H5 C B 74 13.736 12.372 -4.212 1.00 1.00 H +ATOM 2390 H6 C B 74 15.124 13.765 -5.675 1.00 1.00 H +ATOM 2391 P U B 75 14.861 18.391 -8.564 1.00 1.00 P +ATOM 2392 OP1 U B 75 15.671 19.532 -9.047 1.00 1.00 O +ATOM 2393 OP2 U B 75 14.454 18.330 -7.143 1.00 1.00 O +ATOM 2394 O5' U B 75 13.522 18.324 -9.463 1.00 1.00 O +ATOM 2395 C5' U B 75 13.608 18.007 -10.858 1.00 1.00 C +ATOM 2396 C4' U B 75 12.568 16.968 -11.287 1.00 1.00 C +ATOM 2397 O4' U B 75 12.638 15.800 -10.472 1.00 1.00 O +ATOM 2398 C3' U B 75 11.130 17.444 -11.196 1.00 1.00 C +ATOM 2399 O3' U B 75 10.759 18.095 -12.412 1.00 1.00 O +ATOM 2400 C2' U B 75 10.337 16.158 -11.050 1.00 1.00 C +ATOM 2401 O2' U B 75 9.782 15.738 -12.300 1.00 1.00 O +ATOM 2402 C1' U B 75 11.353 15.152 -10.518 1.00 1.00 C +ATOM 2403 N1 U B 75 11.021 14.618 -9.176 1.00 1.00 N +ATOM 2404 C2 U B 75 10.303 13.438 -9.134 1.00 1.00 C +ATOM 2405 O2 U B 75 9.942 12.855 -10.155 1.00 1.00 O +ATOM 2406 N3 U B 75 10.011 12.948 -7.874 1.00 1.00 N +ATOM 2407 C4 U B 75 10.369 13.529 -6.669 1.00 1.00 C +ATOM 2408 O4 U B 75 10.056 13.003 -5.602 1.00 1.00 O +ATOM 2409 C5 U B 75 11.117 14.759 -6.808 1.00 1.00 C +ATOM 2410 C6 U B 75 11.416 15.258 -8.032 1.00 1.00 C +ATOM 2411 H5' U B 75 14.604 17.622 -11.075 1.00 1.00 H +ATOM 2412 H5'' U B 75 13.451 18.920 -11.430 1.00 1.00 H +ATOM 2413 H4' U B 75 12.772 16.676 -12.315 1.00 1.00 H +ATOM 2414 H3' U B 75 10.986 18.095 -10.333 1.00 1.00 H +ATOM 2415 H2' U B 75 9.549 16.303 -10.312 1.00 1.00 H +ATOM 2416 HO2' U B 75 8.828 15.853 -12.234 1.00 1.00 H +ATOM 2417 H1' U B 75 11.416 14.321 -11.222 1.00 1.00 H +ATOM 2418 H3 U B 75 9.487 12.086 -7.828 1.00 1.00 H +ATOM 2419 H5 U B 75 11.445 15.292 -5.915 1.00 1.00 H +ATOM 2420 H6 U B 75 11.979 16.188 -8.107 1.00 1.00 H +ATOM 2421 P U B 76 9.523 19.127 -12.448 1.00 1.00 P +ATOM 2422 OP1 U B 76 9.638 19.943 -13.679 1.00 1.00 O +ATOM 2423 OP2 U B 76 9.435 19.791 -11.129 1.00 1.00 O +ATOM 2424 O5' U B 76 8.249 18.154 -12.611 1.00 1.00 O +ATOM 2425 C5' U B 76 8.008 17.467 -13.844 1.00 1.00 C +ATOM 2426 C4' U B 76 6.869 16.459 -13.711 1.00 1.00 C +ATOM 2427 O4' U B 76 7.187 15.509 -12.700 1.00 1.00 O +ATOM 2428 C3' U B 76 5.537 17.077 -13.326 1.00 1.00 C +ATOM 2429 O3' U B 76 4.787 17.376 -14.507 1.00 1.00 O +ATOM 2430 C2' U B 76 4.840 15.979 -12.535 1.00 1.00 C +ATOM 2431 O2' U B 76 3.953 15.220 -13.366 1.00 1.00 O +ATOM 2432 C1' U B 76 5.990 15.115 -12.014 1.00 1.00 C +ATOM 2433 N1 U B 76 6.244 15.275 -10.567 1.00 1.00 N +ATOM 2434 C2 U B 76 5.677 14.354 -9.707 1.00 1.00 C +ATOM 2435 O2 U B 76 4.984 13.422 -10.110 1.00 1.00 O +ATOM 2436 N3 U B 76 5.934 14.541 -8.360 1.00 1.00 N +ATOM 2437 C4 U B 76 6.699 15.554 -7.809 1.00 1.00 C +ATOM 2438 O4 U B 76 6.862 15.625 -6.591 1.00 1.00 O +ATOM 2439 C5 U B 76 7.254 16.469 -8.781 1.00 1.00 C +ATOM 2440 C6 U B 76 7.016 16.306 -10.105 1.00 1.00 C +ATOM 2441 H5' U B 76 8.914 16.942 -14.143 1.00 1.00 H +ATOM 2442 H5'' U B 76 7.749 18.197 -14.611 1.00 1.00 H +ATOM 2443 H4' U B 76 6.754 15.931 -14.656 1.00 1.00 H +ATOM 2444 H3' U B 76 5.683 17.967 -12.713 1.00 1.00 H +ATOM 2445 H2' U B 76 4.296 16.418 -11.694 1.00 1.00 H +ATOM 2446 HO2' U B 76 3.149 15.733 -13.468 1.00 1.00 H +ATOM 2447 H1' U B 76 5.780 14.068 -12.233 1.00 1.00 H +ATOM 2448 H3 U B 76 5.526 13.875 -7.720 1.00 1.00 H +ATOM 2449 H5 U B 76 7.872 17.301 -8.445 1.00 1.00 H +ATOM 2450 H6 U B 76 7.446 17.010 -10.816 1.00 1.00 H +ATOM 2451 P C B 77 3.650 18.516 -14.486 1.00 1.00 P +ATOM 2452 OP1 C B 77 3.098 18.644 -15.853 1.00 1.00 O +ATOM 2453 OP2 C B 77 4.199 19.705 -13.797 1.00 1.00 O +ATOM 2454 O5' C B 77 2.518 17.866 -13.544 1.00 1.00 O +ATOM 2455 C5' C B 77 1.744 18.688 -12.668 1.00 1.00 C +ATOM 2456 C4' C B 77 0.722 17.869 -11.885 1.00 1.00 C +ATOM 2457 O4' C B 77 1.391 16.875 -11.113 1.00 1.00 O +ATOM 2458 C3' C B 77 -0.117 18.689 -10.918 1.00 1.00 C +ATOM 2459 O3' C B 77 -1.339 19.078 -11.554 1.00 1.00 O +ATOM 2460 C2' C B 77 -0.415 17.728 -9.777 1.00 1.00 C +ATOM 2461 O2' C B 77 -1.703 17.124 -9.930 1.00 1.00 O +ATOM 2462 C1' C B 77 0.701 16.686 -9.870 1.00 1.00 C +ATOM 2463 N1 C B 77 1.701 16.785 -8.791 1.00 1.00 N +ATOM 2464 C2 C B 77 1.351 16.286 -7.546 1.00 1.00 C +ATOM 2465 O2 C B 77 0.239 15.792 -7.371 1.00 1.00 O +ATOM 2466 N3 C B 77 2.266 16.360 -6.541 1.00 1.00 N +ATOM 2467 C4 C B 77 3.474 16.902 -6.749 1.00 1.00 C +ATOM 2468 N4 C B 77 4.346 16.957 -5.743 1.00 1.00 N +ATOM 2469 C5 C B 77 3.838 17.420 -8.032 1.00 1.00 C +ATOM 2470 C6 C B 77 2.926 17.342 -9.020 1.00 1.00 C +ATOM 2471 H5' C B 77 1.220 19.442 -13.257 1.00 1.00 H +ATOM 2472 H5'' C B 77 2.413 19.187 -11.966 1.00 1.00 H +ATOM 2473 H4' C B 77 0.060 17.367 -12.588 1.00 1.00 H +ATOM 2474 H3' C B 77 0.438 19.558 -10.562 1.00 1.00 H +ATOM 2475 H2' C B 77 -0.348 18.256 -8.823 1.00 1.00 H +ATOM 2476 HO2' C B 77 -2.177 17.628 -10.596 1.00 1.00 H +ATOM 2477 H1' C B 77 0.261 15.690 -9.854 1.00 1.00 H +ATOM 2478 H41 C B 77 4.094 16.593 -4.832 1.00 1.00 H +ATOM 2479 H42 C B 77 5.260 17.364 -5.888 1.00 1.00 H +ATOM 2480 H5 C B 77 4.819 17.863 -8.203 1.00 1.00 H +ATOM 2481 H6 C B 77 3.169 17.726 -10.010 1.00 1.00 H +ATOM 2482 P C B 78 -2.146 20.375 -11.049 1.00 1.00 P +ATOM 2483 OP1 C B 78 -3.450 20.410 -11.748 1.00 1.00 O +ATOM 2484 OP2 C B 78 -1.241 21.543 -11.117 1.00 1.00 O +ATOM 2485 O5' C B 78 -2.418 20.038 -9.498 1.00 1.00 O +ATOM 2486 C5' C B 78 -2.230 21.038 -8.494 1.00 1.00 C +ATOM 2487 C4' C B 78 -3.009 20.709 -7.223 1.00 1.00 C +ATOM 2488 O4' C B 78 -2.549 19.471 -6.681 1.00 1.00 O +ATOM 2489 C3' C B 78 -2.878 21.760 -6.132 1.00 1.00 C +ATOM 2490 O3' C B 78 -3.995 22.654 -6.195 1.00 1.00 O +ATOM 2491 C2' C B 78 -2.922 20.963 -4.838 1.00 1.00 C +ATOM 2492 O2' C B 78 -4.246 20.916 -4.297 1.00 1.00 O +ATOM 2493 C1' C B 78 -2.441 19.576 -5.255 1.00 1.00 C +ATOM 2494 N1 C B 78 -1.038 19.300 -4.897 1.00 1.00 N +ATOM 2495 C2 C B 78 -0.759 19.056 -3.562 1.00 1.00 C +ATOM 2496 O2 C B 78 -1.662 19.083 -2.729 1.00 1.00 O +ATOM 2497 N3 C B 78 0.530 18.793 -3.210 1.00 1.00 N +ATOM 2498 C4 C B 78 1.504 18.769 -4.131 1.00 1.00 C +ATOM 2499 N4 C B 78 2.755 18.508 -3.752 1.00 1.00 N +ATOM 2500 C5 C B 78 1.219 19.021 -5.509 1.00 1.00 C +ATOM 2501 C6 C B 78 -0.059 19.280 -5.847 1.00 1.00 C +ATOM 2502 H5' C B 78 -2.568 21.999 -8.880 1.00 1.00 H +ATOM 2503 H5'' C B 78 -1.168 21.105 -8.253 1.00 1.00 H +ATOM 2504 H4' C B 78 -4.062 20.599 -7.479 1.00 1.00 H +ATOM 2505 H3' C B 78 -1.934 22.301 -6.224 1.00 1.00 H +ATOM 2506 H2' C B 78 -2.226 21.394 -4.114 1.00 1.00 H +ATOM 2507 HO2' C B 78 -4.223 21.368 -3.450 1.00 1.00 H +ATOM 2508 H1' C B 78 -3.078 18.822 -4.792 1.00 1.00 H +ATOM 2509 H41 C B 78 2.960 18.331 -2.788 1.00 1.00 H +ATOM 2510 H42 C B 78 3.496 18.489 -4.440 1.00 1.00 H +ATOM 2511 H5 C B 78 2.009 19.004 -6.261 1.00 1.00 H +ATOM 2512 H6 C B 78 -0.313 19.476 -6.889 1.00 1.00 H +ATOM 2513 P U B 79 -3.904 24.116 -5.526 1.00 1.00 P +ATOM 2514 OP1 U B 79 -4.990 24.952 -6.088 1.00 1.00 O +ATOM 2515 OP2 U B 79 -2.500 24.576 -5.605 1.00 1.00 O +ATOM 2516 O5' U B 79 -4.247 23.810 -3.984 1.00 1.00 O +ATOM 2517 C5' U B 79 -3.366 24.243 -2.944 1.00 1.00 C +ATOM 2518 C4' U B 79 -3.681 23.552 -1.620 1.00 1.00 C +ATOM 2519 O4' U B 79 -2.923 22.344 -1.513 1.00 1.00 O +ATOM 2520 C3' U B 79 -3.358 24.398 -0.396 1.00 1.00 C +ATOM 2521 O3' U B 79 -4.544 25.065 0.049 1.00 1.00 O +ATOM 2522 C2' U B 79 -2.913 23.389 0.648 1.00 1.00 C +ATOM 2523 O2' U B 79 -4.000 23.006 1.499 1.00 1.00 O +ATOM 2524 C1' U B 79 -2.415 22.208 -0.179 1.00 1.00 C +ATOM 2525 N1 U B 79 -0.945 22.120 -0.263 1.00 1.00 N +ATOM 2526 C2 U B 79 -0.258 21.915 0.917 1.00 1.00 C +ATOM 2527 O2 U B 79 -0.833 21.815 2.000 1.00 1.00 O +ATOM 2528 N3 U B 79 1.118 21.830 0.812 1.00 1.00 N +ATOM 2529 C4 U B 79 1.856 21.931 -0.356 1.00 1.00 C +ATOM 2530 O4 U B 79 3.081 21.838 -0.332 1.00 1.00 O +ATOM 2531 C5 U B 79 1.056 22.145 -1.540 1.00 1.00 C +ATOM 2532 C6 U B 79 -0.294 22.231 -1.462 1.00 1.00 C +ATOM 2533 H5' U B 79 -3.468 25.321 -2.817 1.00 1.00 H +ATOM 2534 H5'' U B 79 -2.340 24.012 -3.229 1.00 1.00 H +ATOM 2535 H4' U B 79 -4.739 23.298 -1.600 1.00 1.00 H +ATOM 2536 H3' U B 79 -2.561 25.111 -0.613 1.00 1.00 H +ATOM 2537 H2' U B 79 -2.090 23.803 1.236 1.00 1.00 H +ATOM 2538 HO2' U B 79 -3.638 22.442 2.186 1.00 1.00 H +ATOM 2539 H1' U B 79 -2.798 21.285 0.254 1.00 1.00 H +ATOM 2540 H3 U B 79 1.634 21.680 1.667 1.00 1.00 H +ATOM 2541 H5 U B 79 1.545 22.239 -2.510 1.00 1.00 H +ATOM 2542 H6 U B 79 -0.873 22.394 -2.371 1.00 1.00 H +ATOM 2543 P A B 80 -4.452 26.459 0.851 1.00 1.00 P +ATOM 2544 OP1 A B 80 -5.827 26.974 1.045 1.00 1.00 O +ATOM 2545 OP2 A B 80 -3.434 27.306 0.191 1.00 1.00 O +ATOM 2546 O5' A B 80 -3.878 26.006 2.285 1.00 1.00 O +ATOM 2547 C5' A B 80 -4.586 25.055 3.085 1.00 1.00 C +ATOM 2548 C4' A B 80 -3.920 24.857 4.444 1.00 1.00 C +ATOM 2549 O4' A B 80 -2.620 24.291 4.257 1.00 1.00 O +ATOM 2550 C3' A B 80 -3.748 26.150 5.237 1.00 1.00 C +ATOM 2551 O3' A B 80 -3.976 25.891 6.626 1.00 1.00 O +ATOM 2552 C2' A B 80 -2.295 26.534 5.021 1.00 1.00 C +ATOM 2553 O2' A B 80 -1.737 27.139 6.193 1.00 1.00 O +ATOM 2554 C1' A B 80 -1.614 25.209 4.703 1.00 1.00 C +ATOM 2555 N9 A B 80 -0.590 25.303 3.646 1.00 1.00 N +ATOM 2556 C8 A B 80 -0.703 25.826 2.383 1.00 1.00 C +ATOM 2557 N7 A B 80 0.395 25.756 1.684 1.00 1.00 N +ATOM 2558 C5 A B 80 1.300 25.143 2.544 1.00 1.00 C +ATOM 2559 C6 A B 80 2.649 24.779 2.399 1.00 1.00 C +ATOM 2560 N6 A B 80 3.348 24.992 1.284 1.00 1.00 N +ATOM 2561 N1 A B 80 3.244 24.189 3.450 1.00 1.00 N +ATOM 2562 C2 A B 80 2.543 23.977 4.558 1.00 1.00 C +ATOM 2563 N3 A B 80 1.277 24.271 4.815 1.00 1.00 N +ATOM 2564 C4 A B 80 0.708 24.863 3.742 1.00 1.00 C +ATOM 2565 H5' A B 80 -4.619 24.100 2.561 1.00 1.00 H +ATOM 2566 H5'' A B 80 -5.606 25.411 3.238 1.00 1.00 H +ATOM 2567 H4' A B 80 -4.518 24.161 5.030 1.00 1.00 H +ATOM 2568 H3' A B 80 -4.417 26.927 4.863 1.00 1.00 H +ATOM 2569 H2' A B 80 -2.213 27.209 4.163 1.00 1.00 H +ATOM 2570 HO2' A B 80 -0.787 26.997 6.164 1.00 1.00 H +ATOM 2571 H1' A B 80 -1.153 24.821 5.609 1.00 1.00 H +ATOM 2572 H8 A B 80 -1.626 26.262 2.000 1.00 1.00 H +ATOM 2573 H61 A B 80 4.316 24.711 1.232 1.00 1.00 H +ATOM 2574 H62 A B 80 2.908 25.435 0.489 1.00 1.00 H +ATOM 2575 H2 A B 80 3.086 23.495 5.371 1.00 1.00 H +ATOM 2576 P A B 81 -4.385 27.086 7.625 1.00 1.00 P +ATOM 2577 OP1 A B 81 -5.816 27.398 7.411 1.00 1.00 O +ATOM 2578 OP2 A B 81 -3.371 28.157 7.508 1.00 1.00 O +ATOM 2579 O5' A B 81 -4.231 26.402 9.075 1.00 1.00 O +ATOM 2580 C5' A B 81 -5.351 25.773 9.705 1.00 1.00 C +ATOM 2581 C4' A B 81 -4.935 24.521 10.471 1.00 1.00 C +ATOM 2582 O4' A B 81 -4.460 23.537 9.553 1.00 1.00 O +ATOM 2583 C3' A B 81 -3.829 24.756 11.490 1.00 1.00 C +ATOM 2584 O3' A B 81 -4.402 24.954 12.786 1.00 1.00 O +ATOM 2585 C2' A B 81 -3.032 23.462 11.481 1.00 1.00 C +ATOM 2586 O2' A B 81 -3.445 22.591 12.540 1.00 1.00 O +ATOM 2587 C1' A B 81 -3.333 22.853 10.115 1.00 1.00 C +ATOM 2588 N9 A B 81 -2.220 22.969 9.157 1.00 1.00 N +ATOM 2589 C8 A B 81 -2.040 23.885 8.154 1.00 1.00 C +ATOM 2590 N7 A B 81 -0.939 23.714 7.475 1.00 1.00 N +ATOM 2591 C5 A B 81 -0.348 22.605 8.072 1.00 1.00 C +ATOM 2592 C6 A B 81 0.845 21.911 7.814 1.00 1.00 C +ATOM 2593 N6 A B 81 1.694 22.253 6.845 1.00 1.00 N +ATOM 2594 N1 A B 81 1.126 20.854 8.596 1.00 1.00 N +ATOM 2595 C2 A B 81 0.277 20.519 9.561 1.00 1.00 C +ATOM 2596 N3 A B 81 -0.870 21.089 9.900 1.00 1.00 N +ATOM 2597 C4 A B 81 -1.123 22.144 9.098 1.00 1.00 C +ATOM 2598 H5' A B 81 -6.080 25.499 8.943 1.00 1.00 H +ATOM 2599 H5'' A B 81 -5.810 26.478 10.399 1.00 1.00 H +ATOM 2600 H4' A B 81 -5.806 24.118 10.984 1.00 1.00 H +ATOM 2601 H3' A B 81 -3.203 25.602 11.199 1.00 1.00 H +ATOM 2602 H2' A B 81 -1.965 23.683 11.560 1.00 1.00 H +ATOM 2603 HO2' A B 81 -2.704 22.507 13.144 1.00 1.00 H +ATOM 2604 H1' A B 81 -3.581 21.800 10.241 1.00 1.00 H +ATOM 2605 H8 A B 81 -2.751 24.683 7.942 1.00 1.00 H +ATOM 2606 H61 A B 81 2.539 21.720 6.702 1.00 1.00 H +ATOM 2607 H62 A B 81 1.491 23.046 6.253 1.00 1.00 H +ATOM 2608 H2 A B 81 0.565 19.652 10.156 1.00 1.00 H +ATOM 2609 P G B 82 -3.472 25.355 14.038 1.00 1.00 P +ATOM 2610 OP1 G B 82 -4.351 25.681 15.183 1.00 1.00 O +ATOM 2611 OP2 G B 82 -2.468 26.339 13.575 1.00 1.00 O +ATOM 2612 O5' G B 82 -2.711 23.972 14.364 1.00 1.00 O +ATOM 2613 C5' G B 82 -1.461 23.971 15.062 1.00 1.00 C +ATOM 2614 C4' G B 82 -0.620 22.748 14.699 1.00 1.00 C +ATOM 2615 O4' G B 82 -0.683 22.521 13.288 1.00 1.00 O +ATOM 2616 C3' G B 82 0.851 22.875 15.076 1.00 1.00 C +ATOM 2617 O3' G B 82 1.091 22.202 16.317 1.00 1.00 O +ATOM 2618 C2' G B 82 1.580 22.155 13.954 1.00 1.00 C +ATOM 2619 O2' G B 82 1.803 20.778 14.271 1.00 1.00 O +ATOM 2620 C1' G B 82 0.637 22.309 12.770 1.00 1.00 C +ATOM 2621 N9 G B 82 0.954 23.458 11.905 1.00 1.00 N +ATOM 2622 C8 G B 82 0.428 24.723 11.940 1.00 1.00 C +ATOM 2623 N7 G B 82 0.914 25.523 11.033 1.00 1.00 N +ATOM 2624 C5 G B 82 1.829 24.733 10.344 1.00 1.00 C +ATOM 2625 C6 G B 82 2.669 25.060 9.244 1.00 1.00 C +ATOM 2626 O6 G B 82 2.771 26.133 8.653 1.00 1.00 O +ATOM 2627 N1 G B 82 3.440 23.974 8.851 1.00 1.00 N +ATOM 2628 C2 G B 82 3.408 22.728 9.439 1.00 1.00 C +ATOM 2629 N2 G B 82 4.222 21.809 8.920 1.00 1.00 N +ATOM 2630 N3 G B 82 2.620 22.417 10.474 1.00 1.00 N +ATOM 2631 C4 G B 82 1.861 23.466 10.871 1.00 1.00 C +ATOM 2632 H5' G B 82 -1.654 23.962 16.133 1.00 1.00 H +ATOM 2633 H5'' G B 82 -0.908 24.874 14.810 1.00 1.00 H +ATOM 2634 H4' G B 82 -1.035 21.878 15.205 1.00 1.00 H +ATOM 2635 H3' G B 82 1.152 23.921 15.128 1.00 1.00 H +ATOM 2636 H2' G B 82 2.524 22.658 13.740 1.00 1.00 H +ATOM 2637 HO2' G B 82 2.753 20.651 14.335 1.00 1.00 H +ATOM 2638 H1' G B 82 0.651 21.397 12.175 1.00 1.00 H +ATOM 2639 H8 G B 82 -0.329 25.033 12.660 1.00 1.00 H +ATOM 2640 H1 G B 82 4.064 24.131 8.072 1.00 1.00 H +ATOM 2641 H21 G B 82 4.817 22.045 8.139 1.00 1.00 H +ATOM 2642 H22 G B 82 4.244 20.877 9.309 1.00 1.00 H +ATOM 2643 P U B 83 2.053 22.857 17.429 1.00 1.00 P +ATOM 2644 OP1 U B 83 2.157 21.913 18.564 1.00 1.00 O +ATOM 2645 OP2 U B 83 1.607 24.248 17.666 1.00 1.00 O +ATOM 2646 O5' U B 83 3.480 22.907 16.684 1.00 1.00 O +ATOM 2647 C5' U B 83 4.325 21.752 16.650 1.00 1.00 C +ATOM 2648 C4' U B 83 5.654 22.052 15.963 1.00 1.00 C +ATOM 2649 O4' U B 83 5.435 22.260 14.570 1.00 1.00 O +ATOM 2650 C3' U B 83 6.359 23.291 16.494 1.00 1.00 C +ATOM 2651 O3' U B 83 7.295 22.914 17.509 1.00 1.00 O +ATOM 2652 C2' U B 83 7.095 23.829 15.278 1.00 1.00 C +ATOM 2653 O2' U B 83 8.427 23.312 15.195 1.00 1.00 O +ATOM 2654 C1' U B 83 6.238 23.355 14.107 1.00 1.00 C +ATOM 2655 N1 U B 83 5.315 24.386 13.592 1.00 1.00 N +ATOM 2656 C2 U B 83 5.712 25.111 12.485 1.00 1.00 C +ATOM 2657 O2 U B 83 6.798 24.926 11.938 1.00 1.00 O +ATOM 2658 N3 U B 83 4.818 26.061 12.028 1.00 1.00 N +ATOM 2659 C4 U B 83 3.578 26.345 12.575 1.00 1.00 C +ATOM 2660 O4 U B 83 2.861 27.214 12.084 1.00 1.00 O +ATOM 2661 C5 U B 83 3.244 25.539 13.728 1.00 1.00 C +ATOM 2662 C6 U B 83 4.105 24.602 14.194 1.00 1.00 C +ATOM 2663 H5' U B 83 3.816 20.958 16.103 1.00 1.00 H +ATOM 2664 H5'' U B 83 4.516 21.418 17.669 1.00 1.00 H +ATOM 2665 H4' U B 83 6.313 21.194 16.083 1.00 1.00 H +ATOM 2666 H3' U B 83 5.637 24.019 16.868 1.00 1.00 H +ATOM 2667 H2' U B 83 7.109 24.918 15.306 1.00 1.00 H +ATOM 2668 HO2' U B 83 8.988 24.021 14.870 1.00 1.00 H +ATOM 2669 H1' U B 83 6.886 23.009 13.300 1.00 1.00 H +ATOM 2670 H3 U B 83 5.096 26.599 11.220 1.00 1.00 H +ATOM 2671 H5 U B 83 2.288 25.688 14.229 1.00 1.00 H +ATOM 2672 H6 U B 83 3.828 24.008 15.065 1.00 1.00 H +ATOM 2673 P C B 84 7.411 23.768 18.872 1.00 1.00 P +ATOM 2674 OP1 C B 84 8.379 23.090 19.762 1.00 1.00 O +ATOM 2675 OP2 C B 84 6.041 24.054 19.355 1.00 1.00 O +ATOM 2676 O5' C B 84 8.068 25.152 18.372 1.00 1.00 O +ATOM 2677 C5' C B 84 9.476 25.249 18.139 1.00 1.00 C +ATOM 2678 C4' C B 84 9.813 26.455 17.268 1.00 1.00 C +ATOM 2679 O4' C B 84 9.023 26.430 16.084 1.00 1.00 O +ATOM 2680 C3' C B 84 9.546 27.793 17.933 1.00 1.00 C +ATOM 2681 O3' C B 84 10.714 28.234 18.635 1.00 1.00 O +ATOM 2682 C2' C B 84 9.260 28.720 16.761 1.00 1.00 C +ATOM 2683 O2' C B 84 10.438 29.417 16.346 1.00 1.00 O +ATOM 2684 C1' C B 84 8.749 27.779 15.671 1.00 1.00 C +ATOM 2685 N1 C B 84 7.293 27.887 15.441 1.00 1.00 N +ATOM 2686 C2 C B 84 6.862 28.704 14.407 1.00 1.00 C +ATOM 2687 O2 C B 84 7.679 29.320 13.727 1.00 1.00 O +ATOM 2688 N3 C B 84 5.522 28.799 14.175 1.00 1.00 N +ATOM 2689 C4 C B 84 4.644 28.122 14.928 1.00 1.00 C +ATOM 2690 N4 C B 84 3.340 28.238 14.675 1.00 1.00 N +ATOM 2691 C5 C B 84 5.086 27.280 15.996 1.00 1.00 C +ATOM 2692 C6 C B 84 6.412 27.192 16.217 1.00 1.00 C +ATOM 2693 H5' C B 84 9.816 24.345 17.638 1.00 1.00 H +ATOM 2694 H5'' C B 84 9.989 25.344 19.095 1.00 1.00 H +ATOM 2695 H4' C B 84 10.862 26.405 16.985 1.00 1.00 H +ATOM 2696 H3' C B 84 8.683 27.731 18.597 1.00 1.00 H +ATOM 2697 H2' C B 84 8.473 29.420 17.035 1.00 1.00 H +ATOM 2698 HO2' C B 84 10.895 29.706 17.140 1.00 1.00 H +ATOM 2699 H1' C B 84 9.279 27.981 14.739 1.00 1.00 H +ATOM 2700 H41 C B 84 3.024 28.829 13.924 1.00 1.00 H +ATOM 2701 H42 C B 84 2.672 27.731 15.236 1.00 1.00 H +ATOM 2702 H5 C B 84 4.374 26.726 16.610 1.00 1.00 H +ATOM 2703 H6 C B 84 6.784 26.559 17.023 1.00 1.00 H +ATOM 2704 P C B 85 10.577 29.205 19.915 1.00 1.00 P +ATOM 2705 OP1 C B 85 11.821 29.100 20.710 1.00 1.00 O +ATOM 2706 OP2 C B 85 9.269 28.945 20.556 1.00 1.00 O +ATOM 2707 O5' C B 85 10.529 30.672 19.250 1.00 1.00 O +ATOM 2708 C5' C B 85 11.727 31.298 18.780 1.00 1.00 C +ATOM 2709 C4' C B 85 11.419 32.527 17.929 1.00 1.00 C +ATOM 2710 O4' C B 85 10.481 32.186 16.908 1.00 1.00 O +ATOM 2711 C3' C B 85 10.811 33.685 18.701 1.00 1.00 C +ATOM 2712 O3' C B 85 11.845 34.555 19.172 1.00 1.00 O +ATOM 2713 C2' C B 85 9.970 34.406 17.661 1.00 1.00 C +ATOM 2714 O2' C B 85 10.705 35.462 17.036 1.00 1.00 O +ATOM 2715 C1' C B 85 9.623 33.311 16.656 1.00 1.00 C +ATOM 2716 N1 C B 85 8.223 32.844 16.747 1.00 1.00 N +ATOM 2717 C2 C B 85 7.284 33.473 15.946 1.00 1.00 C +ATOM 2718 O2 C B 85 7.629 34.383 15.193 1.00 1.00 O +ATOM 2719 N3 C B 85 5.989 33.059 16.022 1.00 1.00 N +ATOM 2720 C4 C B 85 5.631 32.067 16.849 1.00 1.00 C +ATOM 2721 N4 C B 85 4.354 31.686 16.900 1.00 1.00 N +ATOM 2722 C5 C B 85 6.599 31.415 17.677 1.00 1.00 C +ATOM 2723 C6 C B 85 7.877 31.832 17.594 1.00 1.00 C +ATOM 2724 H5' C B 85 12.291 30.583 18.182 1.00 1.00 H +ATOM 2725 H5'' C B 85 12.329 31.599 19.637 1.00 1.00 H +ATOM 2726 H4' C B 85 12.336 32.865 17.452 1.00 1.00 H +ATOM 2727 H3' C B 85 10.191 33.324 19.524 1.00 1.00 H +ATOM 2728 H2' C B 85 9.058 34.791 18.121 1.00 1.00 H +ATOM 2729 HO2' C B 85 11.600 35.146 16.898 1.00 1.00 H +ATOM 2730 H1' C B 85 9.811 33.681 15.649 1.00 1.00 H +ATOM 2731 H41 C B 85 3.669 32.141 16.317 1.00 1.00 H +ATOM 2732 H42 C B 85 4.076 30.939 17.521 1.00 1.00 H +ATOM 2733 H5 C B 85 6.311 30.608 18.351 1.00 1.00 H +ATOM 2734 H6 C B 85 8.641 31.357 18.210 1.00 1.00 H +ATOM 2735 P U B 86 11.529 35.658 20.303 1.00 1.00 P +ATOM 2736 OP1 U B 86 12.679 36.587 20.378 1.00 1.00 O +ATOM 2737 OP2 U B 86 11.067 34.955 21.521 1.00 1.00 O +ATOM 2738 O5' U B 86 10.277 36.453 19.674 1.00 1.00 O +ATOM 2739 C5' U B 86 10.479 37.419 18.640 1.00 1.00 C +ATOM 2740 C4' U B 86 9.171 38.086 18.224 1.00 1.00 C +ATOM 2741 O4' U B 86 8.207 37.103 17.879 1.00 1.00 O +ATOM 2742 C3' U B 86 8.539 38.947 19.311 1.00 1.00 C +ATOM 2743 O3' U B 86 8.898 40.324 19.151 1.00 1.00 O +ATOM 2744 C2' U B 86 7.031 38.739 19.123 1.00 1.00 C +ATOM 2745 O2' U B 86 6.378 39.962 18.768 1.00 1.00 O +ATOM 2746 C1' U B 86 6.926 37.715 17.998 1.00 1.00 C +ATOM 2747 N1 U B 86 5.923 36.657 18.245 1.00 1.00 N +ATOM 2748 C2 U B 86 4.651 36.854 17.742 1.00 1.00 C +ATOM 2749 O2 U B 86 4.350 37.859 17.102 1.00 1.00 O +ATOM 2750 N3 U B 86 3.733 35.852 18.003 1.00 1.00 N +ATOM 2751 C4 U B 86 3.973 34.689 18.714 1.00 1.00 C +ATOM 2752 O4 U B 86 3.078 33.864 18.885 1.00 1.00 O +ATOM 2753 C5 U B 86 5.328 34.567 19.202 1.00 1.00 C +ATOM 2754 C6 U B 86 6.245 35.535 18.959 1.00 1.00 C +ATOM 2755 H5' U B 86 10.918 36.926 17.773 1.00 1.00 H +ATOM 2756 H5'' U B 86 11.168 38.184 19.000 1.00 1.00 H +ATOM 2757 H4' U B 86 9.356 38.705 17.348 1.00 1.00 H +ATOM 2758 H3' U B 86 8.844 38.582 20.296 1.00 1.00 H +ATOM 2759 HO3' U B 86 8.471 40.640 18.352 1.00 1.00 H +ATOM 2760 H2' U B 86 6.594 38.321 20.032 1.00 1.00 H +ATOM 2761 HO2' U B 86 5.880 39.796 17.964 1.00 1.00 H +ATOM 2762 H1' U B 86 6.690 38.231 17.066 1.00 1.00 H +ATOM 2763 H3 U B 86 2.799 35.984 17.642 1.00 1.00 H +ATOM 2764 H5 U B 86 5.615 33.686 19.777 1.00 1.00 H +ATOM 2765 H6 U B 86 7.259 35.417 19.341 1.00 1.00 H +TER 2766 U B 86 +ENDMDL +MODEL 10 +ATOM 1 O5' G A 1 5.584 -38.967 7.463 1.00 1.00 O +ATOM 2 C5' G A 1 6.746 -39.507 6.828 1.00 1.00 C +ATOM 3 C4' G A 1 6.389 -40.191 5.511 1.00 1.00 C +ATOM 4 O4' G A 1 5.650 -41.387 5.774 1.00 1.00 O +ATOM 5 C3' G A 1 5.544 -39.328 4.578 1.00 1.00 C +ATOM 6 O3' G A 1 6.381 -38.714 3.593 1.00 1.00 O +ATOM 7 C2' G A 1 4.611 -40.322 3.911 1.00 1.00 C +ATOM 8 O2' G A 1 5.169 -40.828 2.693 1.00 1.00 O +ATOM 9 C1' G A 1 4.476 -41.419 4.957 1.00 1.00 C +ATOM 10 N9 G A 1 3.312 -41.255 5.846 1.00 1.00 N +ATOM 11 C8 G A 1 3.284 -40.895 7.168 1.00 1.00 C +ATOM 12 N7 G A 1 2.085 -40.844 7.677 1.00 1.00 N +ATOM 13 C5 G A 1 1.255 -41.195 6.616 1.00 1.00 C +ATOM 14 C6 G A 1 -0.161 -41.311 6.566 1.00 1.00 C +ATOM 15 O6 G A 1 -0.975 -41.121 7.468 1.00 1.00 O +ATOM 16 N1 G A 1 -0.597 -41.688 5.303 1.00 1.00 N +ATOM 17 C2 G A 1 0.225 -41.926 4.220 1.00 1.00 C +ATOM 18 N2 G A 1 -0.379 -42.280 3.086 1.00 1.00 N +ATOM 19 N3 G A 1 1.556 -41.816 4.265 1.00 1.00 N +ATOM 20 C4 G A 1 1.999 -41.448 5.490 1.00 1.00 C +ATOM 21 H5' G A 1 7.213 -40.230 7.500 1.00 1.00 H +ATOM 22 H5'' G A 1 7.450 -38.705 6.627 1.00 1.00 H +ATOM 23 H4' G A 1 7.309 -40.464 4.998 1.00 1.00 H +ATOM 24 H3' G A 1 4.981 -38.582 5.142 1.00 1.00 H +ATOM 25 H2' G A 1 3.639 -39.857 3.730 1.00 1.00 H +ATOM 26 HO2' G A 1 6.089 -41.040 2.869 1.00 1.00 H +ATOM 27 H1' G A 1 4.410 -42.386 4.459 1.00 1.00 H +ATOM 28 H8 G A 1 4.183 -40.673 7.745 1.00 1.00 H +ATOM 29 H1 G A 1 -1.595 -41.791 5.190 1.00 1.00 H +ATOM 30 H21 G A 1 -1.386 -42.362 3.054 1.00 1.00 H +ATOM 31 H22 G A 1 0.168 -42.467 2.259 1.00 1.00 H +ATOM 32 HO5' G A 1 4.831 -39.167 6.902 1.00 1.00 H +ATOM 33 P G A 2 6.029 -37.250 3.021 1.00 1.00 P +ATOM 34 OP1 G A 2 6.977 -36.938 1.928 1.00 1.00 O +ATOM 35 OP2 G A 2 5.895 -36.325 4.169 1.00 1.00 O +ATOM 36 O5' G A 2 4.568 -37.464 2.376 1.00 1.00 O +ATOM 37 C5' G A 2 4.387 -38.325 1.249 1.00 1.00 C +ATOM 38 C4' G A 2 2.907 -38.599 0.985 1.00 1.00 C +ATOM 39 O4' G A 2 2.308 -39.174 2.144 1.00 1.00 O +ATOM 40 C3' G A 2 2.093 -37.359 0.646 1.00 1.00 C +ATOM 41 O3' G A 2 2.071 -37.173 -0.776 1.00 1.00 O +ATOM 42 C2' G A 2 0.698 -37.694 1.155 1.00 1.00 C +ATOM 43 O2' G A 2 -0.134 -38.199 0.106 1.00 1.00 O +ATOM 44 C1' G A 2 0.942 -38.749 2.232 1.00 1.00 C +ATOM 45 N9 G A 2 0.714 -38.255 3.599 1.00 1.00 N +ATOM 46 C8 G A 2 1.630 -37.872 4.545 1.00 1.00 C +ATOM 47 N7 G A 2 1.098 -37.508 5.679 1.00 1.00 N +ATOM 48 C5 G A 2 -0.270 -37.658 5.471 1.00 1.00 C +ATOM 49 C6 G A 2 -1.360 -37.413 6.353 1.00 1.00 C +ATOM 50 O6 G A 2 -1.327 -37.008 7.513 1.00 1.00 O +ATOM 51 N1 G A 2 -2.579 -37.693 5.747 1.00 1.00 N +ATOM 52 C2 G A 2 -2.733 -38.152 4.457 1.00 1.00 C +ATOM 53 N2 G A 2 -3.984 -38.364 4.049 1.00 1.00 N +ATOM 54 N3 G A 2 -1.711 -38.383 3.626 1.00 1.00 N +ATOM 55 C4 G A 2 -0.515 -38.115 4.200 1.00 1.00 C +ATOM 56 H5' G A 2 4.895 -39.270 1.438 1.00 1.00 H +ATOM 57 H5'' G A 2 4.824 -37.855 0.367 1.00 1.00 H +ATOM 58 H4' G A 2 2.821 -39.311 0.166 1.00 1.00 H +ATOM 59 H3' G A 2 2.493 -36.480 1.157 1.00 1.00 H +ATOM 60 H2' G A 2 0.249 -36.812 1.611 1.00 1.00 H +ATOM 61 HO2' G A 2 -0.545 -39.004 0.429 1.00 1.00 H +ATOM 62 H1' G A 2 0.285 -39.601 2.055 1.00 1.00 H +ATOM 63 H8 G A 2 2.705 -37.873 4.366 1.00 1.00 H +ATOM 64 H1 G A 2 -3.401 -37.543 6.313 1.00 1.00 H +ATOM 65 H21 G A 2 -4.758 -38.186 4.681 1.00 1.00 H +ATOM 66 H22 G A 2 -4.161 -38.700 3.114 1.00 1.00 H +ATOM 67 P G A 3 1.895 -35.704 -1.416 1.00 1.00 P +ATOM 68 OP1 G A 3 2.257 -35.780 -2.849 1.00 1.00 O +ATOM 69 OP2 G A 3 2.580 -34.731 -0.535 1.00 1.00 O +ATOM 70 O5' G A 3 0.307 -35.445 -1.315 1.00 1.00 O +ATOM 71 C5' G A 3 -0.604 -36.164 -2.155 1.00 1.00 C +ATOM 72 C4' G A 3 -2.055 -35.925 -1.745 1.00 1.00 C +ATOM 73 O4' G A 3 -2.232 -36.284 -0.379 1.00 1.00 O +ATOM 74 C3' G A 3 -2.515 -34.480 -1.881 1.00 1.00 C +ATOM 75 O3' G A 3 -3.123 -34.281 -3.165 1.00 1.00 O +ATOM 76 C2' G A 3 -3.561 -34.329 -0.788 1.00 1.00 C +ATOM 77 O2' G A 3 -4.884 -34.526 -1.301 1.00 1.00 O +ATOM 78 C1' G A 3 -3.192 -35.410 0.226 1.00 1.00 C +ATOM 79 N9 G A 3 -2.596 -34.880 1.464 1.00 1.00 N +ATOM 80 C8 G A 3 -1.277 -34.638 1.750 1.00 1.00 C +ATOM 81 N7 G A 3 -1.072 -34.188 2.957 1.00 1.00 N +ATOM 82 C5 G A 3 -2.347 -34.125 3.511 1.00 1.00 C +ATOM 83 C6 G A 3 -2.756 -33.708 4.809 1.00 1.00 C +ATOM 84 O6 G A 3 -2.058 -33.306 5.737 1.00 1.00 O +ATOM 85 N1 G A 3 -4.134 -33.798 4.961 1.00 1.00 N +ATOM 86 C2 G A 3 -5.010 -34.234 3.991 1.00 1.00 C +ATOM 87 N2 G A 3 -6.299 -34.247 4.324 1.00 1.00 N +ATOM 88 N3 G A 3 -4.628 -34.628 2.772 1.00 1.00 N +ATOM 89 C4 G A 3 -3.286 -34.547 2.605 1.00 1.00 C +ATOM 90 H5' G A 3 -0.386 -37.230 -2.084 1.00 1.00 H +ATOM 91 H5'' G A 3 -0.468 -35.841 -3.188 1.00 1.00 H +ATOM 92 H4' G A 3 -2.700 -36.558 -2.351 1.00 1.00 H +ATOM 93 H3' G A 3 -1.684 -33.789 -1.724 1.00 1.00 H +ATOM 94 H2' G A 3 -3.470 -33.347 -0.324 1.00 1.00 H +ATOM 95 HO2' G A 3 -4.879 -35.353 -1.788 1.00 1.00 H +ATOM 96 H1' G A 3 -4.084 -35.981 0.483 1.00 1.00 H +ATOM 97 H8 G A 3 -0.472 -34.804 1.034 1.00 1.00 H +ATOM 98 H1 G A 3 -4.500 -33.517 5.860 1.00 1.00 H +ATOM 99 H21 G A 3 -6.586 -33.948 5.244 1.00 1.00 H +ATOM 100 H22 G A 3 -6.990 -34.557 3.656 1.00 1.00 H +ATOM 101 P A A 4 -3.101 -32.829 -3.869 1.00 1.00 P +ATOM 102 OP1 A A 4 -3.397 -33.012 -5.307 1.00 1.00 O +ATOM 103 OP2 A A 4 -1.862 -32.135 -3.455 1.00 1.00 O +ATOM 104 O5' A A 4 -4.353 -32.069 -3.194 1.00 1.00 O +ATOM 105 C5' A A 4 -5.698 -32.412 -3.550 1.00 1.00 C +ATOM 106 C4' A A 4 -6.717 -31.582 -2.769 1.00 1.00 C +ATOM 107 O4' A A 4 -6.638 -31.905 -1.381 1.00 1.00 O +ATOM 108 C3' A A 4 -6.518 -30.077 -2.895 1.00 1.00 C +ATOM 109 O3' A A 4 -7.359 -29.564 -3.933 1.00 1.00 O +ATOM 110 C2' A A 4 -6.974 -29.542 -1.548 1.00 1.00 C +ATOM 111 O2' A A 4 -8.361 -29.185 -1.571 1.00 1.00 O +ATOM 112 C1' A A 4 -6.717 -30.707 -0.598 1.00 1.00 C +ATOM 113 N9 A A 4 -5.457 -30.591 0.158 1.00 1.00 N +ATOM 114 C8 A A 4 -4.183 -30.890 -0.249 1.00 1.00 C +ATOM 115 N7 A A 4 -3.274 -30.680 0.662 1.00 1.00 N +ATOM 116 C5 A A 4 -3.999 -30.209 1.753 1.00 1.00 C +ATOM 117 C6 A A 4 -3.617 -29.803 3.041 1.00 1.00 C +ATOM 118 N6 A A 4 -2.350 -29.807 3.462 1.00 1.00 N +ATOM 119 N1 A A 4 -4.589 -29.392 3.872 1.00 1.00 N +ATOM 120 C2 A A 4 -5.847 -29.388 3.446 1.00 1.00 C +ATOM 121 N3 A A 4 -6.330 -29.744 2.265 1.00 1.00 N +ATOM 122 C4 A A 4 -5.330 -30.152 1.454 1.00 1.00 C +ATOM 123 H5' A A 4 -5.865 -33.468 -3.339 1.00 1.00 H +ATOM 124 H5'' A A 4 -5.839 -32.236 -4.617 1.00 1.00 H +ATOM 125 H4' A A 4 -7.716 -31.833 -3.122 1.00 1.00 H +ATOM 126 H3' A A 4 -5.468 -29.836 -3.076 1.00 1.00 H +ATOM 127 H2' A A 4 -6.360 -28.686 -1.259 1.00 1.00 H +ATOM 128 HO2' A A 4 -8.713 -29.351 -0.693 1.00 1.00 H +ATOM 129 H1' A A 4 -7.546 -30.789 0.104 1.00 1.00 H +ATOM 130 H8 A A 4 -3.949 -31.268 -1.245 1.00 1.00 H +ATOM 131 H61 A A 4 -2.129 -29.505 4.399 1.00 1.00 H +ATOM 132 H62 A A 4 -1.614 -30.115 2.842 1.00 1.00 H +ATOM 133 H2 A A 4 -6.585 -29.045 4.171 1.00 1.00 H +ATOM 134 P U A 5 -6.938 -28.245 -4.758 1.00 1.00 P +ATOM 135 OP1 U A 5 -8.049 -27.900 -5.674 1.00 1.00 O +ATOM 136 OP2 U A 5 -5.576 -28.453 -5.298 1.00 1.00 O +ATOM 137 O5' U A 5 -6.859 -27.115 -3.614 1.00 1.00 O +ATOM 138 C5' U A 5 -8.036 -26.686 -2.925 1.00 1.00 C +ATOM 139 C4' U A 5 -7.698 -25.726 -1.786 1.00 1.00 C +ATOM 140 O4' U A 5 -6.973 -26.416 -0.771 1.00 1.00 O +ATOM 141 C3' U A 5 -6.842 -24.546 -2.211 1.00 1.00 C +ATOM 142 O3' U A 5 -7.688 -23.444 -2.554 1.00 1.00 O +ATOM 143 C2' U A 5 -6.035 -24.215 -0.963 1.00 1.00 C +ATOM 144 O2' U A 5 -6.657 -23.174 -0.202 1.00 1.00 O +ATOM 145 C1' U A 5 -6.008 -25.531 -0.182 1.00 1.00 C +ATOM 146 N1 U A 5 -4.699 -26.222 -0.212 1.00 1.00 N +ATOM 147 C2 U A 5 -3.867 -26.077 0.881 1.00 1.00 C +ATOM 148 O2 U A 5 -4.183 -25.399 1.858 1.00 1.00 O +ATOM 149 N3 U A 5 -2.655 -26.740 0.815 1.00 1.00 N +ATOM 150 C4 U A 5 -2.210 -27.525 -0.236 1.00 1.00 C +ATOM 151 O4 U A 5 -1.109 -28.070 -0.188 1.00 1.00 O +ATOM 152 C5 U A 5 -3.143 -27.620 -1.335 1.00 1.00 C +ATOM 153 C6 U A 5 -4.337 -26.980 -1.293 1.00 1.00 C +ATOM 154 H5' U A 5 -8.547 -27.556 -2.515 1.00 1.00 H +ATOM 155 H5'' U A 5 -8.699 -26.182 -3.629 1.00 1.00 H +ATOM 156 H4' U A 5 -8.624 -25.353 -1.353 1.00 1.00 H +ATOM 157 H3' U A 5 -6.186 -24.818 -3.039 1.00 1.00 H +ATOM 158 H2' U A 5 -5.017 -23.931 -1.244 1.00 1.00 H +ATOM 159 HO2' U A 5 -5.972 -22.544 0.034 1.00 1.00 H +ATOM 160 H1' U A 5 -6.291 -25.336 0.852 1.00 1.00 H +ATOM 161 H3 U A 5 -2.037 -26.643 1.608 1.00 1.00 H +ATOM 162 H5 U A 5 -2.884 -28.216 -2.210 1.00 1.00 H +ATOM 163 H6 U A 5 -5.023 -27.071 -2.135 1.00 1.00 H +ATOM 164 P A A 6 -7.124 -22.228 -3.444 1.00 1.00 P +ATOM 165 OP1 A A 6 -7.661 -22.366 -4.817 1.00 1.00 O +ATOM 166 OP2 A A 6 -5.664 -22.141 -3.229 1.00 1.00 O +ATOM 167 O5' A A 6 -7.812 -20.944 -2.760 1.00 1.00 O +ATOM 168 C5' A A 6 -9.140 -21.037 -2.243 1.00 1.00 C +ATOM 169 C4' A A 6 -9.230 -20.495 -0.819 1.00 1.00 C +ATOM 170 O4' A A 6 -8.065 -20.890 -0.083 1.00 1.00 O +ATOM 171 C3' A A 6 -9.340 -18.974 -0.732 1.00 1.00 C +ATOM 172 O3' A A 6 -10.318 -18.626 0.258 1.00 1.00 O +ATOM 173 C2' A A 6 -7.964 -18.508 -0.275 1.00 1.00 C +ATOM 174 O2' A A 6 -8.066 -17.411 0.640 1.00 1.00 O +ATOM 175 C1' A A 6 -7.368 -19.735 0.401 1.00 1.00 C +ATOM 176 N9 A A 6 -5.933 -19.933 0.131 1.00 1.00 N +ATOM 177 C8 A A 6 -5.269 -19.897 -1.069 1.00 1.00 C +ATOM 178 N7 A A 6 -3.987 -20.117 -0.971 1.00 1.00 N +ATOM 179 C5 A A 6 -3.787 -20.312 0.393 1.00 1.00 C +ATOM 180 C6 A A 6 -2.639 -20.590 1.152 1.00 1.00 C +ATOM 181 N6 A A 6 -1.425 -20.726 0.619 1.00 1.00 N +ATOM 182 N1 A A 6 -2.796 -20.721 2.481 1.00 1.00 N +ATOM 183 C2 A A 6 -4.007 -20.585 3.006 1.00 1.00 C +ATOM 184 N3 A A 6 -5.157 -20.327 2.402 1.00 1.00 N +ATOM 185 C4 A A 6 -4.967 -20.201 1.071 1.00 1.00 C +ATOM 186 H5' A A 6 -9.449 -22.082 -2.243 1.00 1.00 H +ATOM 187 H5'' A A 6 -9.814 -20.469 -2.885 1.00 1.00 H +ATOM 188 H4' A A 6 -10.103 -20.937 -0.341 1.00 1.00 H +ATOM 189 H3' A A 6 -9.593 -18.544 -1.703 1.00 1.00 H +ATOM 190 H2' A A 6 -7.359 -18.231 -1.142 1.00 1.00 H +ATOM 191 HO2' A A 6 -7.665 -16.647 0.218 1.00 1.00 H +ATOM 192 H1' A A 6 -7.509 -19.652 1.478 1.00 1.00 H +ATOM 193 H8 A A 6 -5.767 -19.697 -2.019 1.00 1.00 H +ATOM 194 H61 A A 6 -0.636 -20.926 1.216 1.00 1.00 H +ATOM 195 H62 A A 6 -1.285 -20.629 -0.380 1.00 1.00 H +ATOM 196 H2 A A 6 -4.063 -20.702 4.089 1.00 1.00 H +ATOM 197 P U A 7 -10.700 -17.084 0.525 1.00 1.00 P +ATOM 198 OP1 U A 7 -12.173 -16.955 0.467 1.00 1.00 O +ATOM 199 OP2 U A 7 -9.850 -16.238 -0.341 1.00 1.00 O +ATOM 200 O5' U A 7 -10.236 -16.865 2.051 1.00 1.00 O +ATOM 201 C5' U A 7 -11.192 -16.547 3.066 1.00 1.00 C +ATOM 202 C4' U A 7 -10.508 -15.999 4.320 1.00 1.00 C +ATOM 203 O4' U A 7 -10.708 -16.900 5.403 1.00 1.00 O +ATOM 204 C3' U A 7 -9.000 -15.804 4.164 1.00 1.00 C +ATOM 205 O3' U A 7 -8.632 -14.527 4.685 1.00 1.00 O +ATOM 206 C2' U A 7 -8.360 -16.893 5.025 1.00 1.00 C +ATOM 207 O2' U A 7 -7.617 -16.319 6.104 1.00 1.00 O +ATOM 208 C1' U A 7 -9.543 -17.704 5.550 1.00 1.00 C +ATOM 209 N1 U A 7 -9.795 -18.969 4.826 1.00 1.00 N +ATOM 210 C2 U A 7 -10.276 -20.038 5.558 1.00 1.00 C +ATOM 211 O2 U A 7 -10.481 -19.961 6.768 1.00 1.00 O +ATOM 212 N3 U A 7 -10.511 -21.203 4.850 1.00 1.00 N +ATOM 213 C4 U A 7 -10.311 -21.389 3.493 1.00 1.00 C +ATOM 214 O4 U A 7 -10.555 -22.474 2.966 1.00 1.00 O +ATOM 215 C5 U A 7 -9.810 -20.220 2.807 1.00 1.00 C +ATOM 216 C6 U A 7 -9.571 -19.067 3.479 1.00 1.00 C +ATOM 217 H5' U A 7 -11.746 -17.449 3.329 1.00 1.00 H +ATOM 218 H5'' U A 7 -11.888 -15.802 2.678 1.00 1.00 H +ATOM 219 H4' U A 7 -10.959 -15.040 4.582 1.00 1.00 H +ATOM 220 H3' U A 7 -8.698 -15.907 3.122 1.00 1.00 H +ATOM 221 H2' U A 7 -7.711 -17.526 4.411 1.00 1.00 H +ATOM 222 HO2' U A 7 -7.370 -17.037 6.694 1.00 1.00 H +ATOM 223 H1' U A 7 -9.387 -17.914 6.608 1.00 1.00 H +ATOM 224 H3 U A 7 -10.861 -21.993 5.373 1.00 1.00 H +ATOM 225 H5 U A 7 -9.620 -20.266 1.734 1.00 1.00 H +ATOM 226 H6 U A 7 -9.192 -18.201 2.936 1.00 1.00 H +ATOM 227 P G A 8 -7.211 -13.883 4.306 1.00 1.00 P +ATOM 228 OP1 G A 8 -7.076 -12.597 5.027 1.00 1.00 O +ATOM 229 OP2 G A 8 -7.069 -13.923 2.834 1.00 1.00 O +ATOM 230 O5' G A 8 -6.167 -14.931 4.946 1.00 1.00 O +ATOM 231 C5' G A 8 -5.490 -15.888 4.123 1.00 1.00 C +ATOM 232 C4' G A 8 -4.220 -15.305 3.511 1.00 1.00 C +ATOM 233 O4' G A 8 -3.654 -16.246 2.598 1.00 1.00 O +ATOM 234 C3' G A 8 -4.454 -14.015 2.741 1.00 1.00 C +ATOM 235 O3' G A 8 -4.115 -12.894 3.559 1.00 1.00 O +ATOM 236 C2' G A 8 -3.496 -14.090 1.568 1.00 1.00 C +ATOM 237 O2' G A 8 -2.286 -13.369 1.828 1.00 1.00 O +ATOM 238 C1' G A 8 -3.236 -15.578 1.400 1.00 1.00 C +ATOM 239 N9 G A 8 -3.975 -16.171 0.275 1.00 1.00 N +ATOM 240 C8 G A 8 -5.158 -16.863 0.299 1.00 1.00 C +ATOM 241 N7 G A 8 -5.561 -17.264 -0.872 1.00 1.00 N +ATOM 242 C5 G A 8 -4.576 -16.808 -1.743 1.00 1.00 C +ATOM 243 C6 G A 8 -4.477 -16.947 -3.154 1.00 1.00 C +ATOM 244 O6 G A 8 -5.257 -17.506 -3.922 1.00 1.00 O +ATOM 245 N1 G A 8 -3.329 -16.344 -3.646 1.00 1.00 N +ATOM 246 C2 G A 8 -2.390 -15.687 -2.879 1.00 1.00 C +ATOM 247 N2 G A 8 -1.349 -15.174 -3.536 1.00 1.00 N +ATOM 248 N3 G A 8 -2.480 -15.554 -1.550 1.00 1.00 N +ATOM 249 C4 G A 8 -3.598 -16.136 -1.051 1.00 1.00 C +ATOM 250 H5' G A 8 -6.158 -16.203 3.322 1.00 1.00 H +ATOM 251 H5'' G A 8 -5.227 -16.755 4.727 1.00 1.00 H +ATOM 252 H4' G A 8 -3.499 -15.118 4.305 1.00 1.00 H +ATOM 253 H3' G A 8 -5.483 -13.952 2.389 1.00 1.00 H +ATOM 254 H2' G A 8 -3.992 -13.706 0.673 1.00 1.00 H +ATOM 255 HO2' G A 8 -2.285 -13.139 2.760 1.00 1.00 H +ATOM 256 H1' G A 8 -2.171 -15.742 1.251 1.00 1.00 H +ATOM 257 H8 G A 8 -5.708 -17.065 1.218 1.00 1.00 H +ATOM 258 H1 G A 8 -3.190 -16.400 -4.645 1.00 1.00 H +ATOM 259 H21 G A 8 -1.287 -15.279 -4.539 1.00 1.00 H +ATOM 260 H22 G A 8 -0.629 -14.683 -3.037 1.00 1.00 H +ATOM 261 P G A 9 -4.416 -11.403 3.037 1.00 1.00 P +ATOM 262 OP1 G A 9 -3.830 -10.444 4.001 1.00 1.00 O +ATOM 263 OP2 G A 9 -5.850 -11.314 2.685 1.00 1.00 O +ATOM 264 O5' G A 9 -3.558 -11.339 1.678 1.00 1.00 O +ATOM 265 C5' G A 9 -4.176 -10.947 0.450 1.00 1.00 C +ATOM 266 C4' G A 9 -3.161 -10.855 -0.684 1.00 1.00 C +ATOM 267 O4' G A 9 -2.899 -12.159 -1.208 1.00 1.00 O +ATOM 268 C3' G A 9 -3.622 -9.995 -1.850 1.00 1.00 C +ATOM 269 O3' G A 9 -3.156 -8.652 -1.675 1.00 1.00 O +ATOM 270 C2' G A 9 -2.935 -10.628 -3.047 1.00 1.00 C +ATOM 271 O2' G A 9 -1.663 -10.019 -3.299 1.00 1.00 O +ATOM 272 C1' G A 9 -2.782 -12.086 -2.636 1.00 1.00 C +ATOM 273 N9 G A 9 -3.805 -12.975 -3.220 1.00 1.00 N +ATOM 274 C8 G A 9 -4.717 -13.775 -2.582 1.00 1.00 C +ATOM 275 N7 G A 9 -5.487 -14.448 -3.391 1.00 1.00 N +ATOM 276 C5 G A 9 -5.055 -14.069 -4.658 1.00 1.00 C +ATOM 277 C6 G A 9 -5.521 -14.475 -5.940 1.00 1.00 C +ATOM 278 O6 G A 9 -6.425 -15.265 -6.208 1.00 1.00 O +ATOM 279 N1 G A 9 -4.812 -13.855 -6.959 1.00 1.00 N +ATOM 280 C2 G A 9 -3.783 -12.956 -6.775 1.00 1.00 C +ATOM 281 N2 G A 9 -3.222 -12.465 -7.881 1.00 1.00 N +ATOM 282 N3 G A 9 -3.344 -12.572 -5.572 1.00 1.00 N +ATOM 283 C4 G A 9 -4.024 -13.168 -4.564 1.00 1.00 C +ATOM 284 H5' G A 9 -4.648 -9.975 0.584 1.00 1.00 H +ATOM 285 H5'' G A 9 -4.938 -11.680 0.186 1.00 1.00 H +ATOM 286 H4' G A 9 -2.230 -10.449 -0.291 1.00 1.00 H +ATOM 287 H3' G A 9 -4.707 -10.031 -1.957 1.00 1.00 H +ATOM 288 H2' G A 9 -3.577 -10.559 -3.925 1.00 1.00 H +ATOM 289 HO2' G A 9 -1.135 -10.656 -3.789 1.00 1.00 H +ATOM 290 H1' G A 9 -1.795 -12.440 -2.933 1.00 1.00 H +ATOM 291 H8 G A 9 -4.791 -13.843 -1.496 1.00 1.00 H +ATOM 292 H1 G A 9 -5.087 -14.094 -7.901 1.00 1.00 H +ATOM 293 H21 G A 9 -3.557 -12.758 -8.791 1.00 1.00 H +ATOM 294 H22 G A 9 -2.463 -11.803 -7.810 1.00 1.00 H +ATOM 295 P A A 10 -4.171 -7.408 -1.814 1.00 1.00 P +ATOM 296 OP1 A A 10 -3.547 -6.228 -1.176 1.00 1.00 O +ATOM 297 OP2 A A 10 -5.514 -7.856 -1.381 1.00 1.00 O +ATOM 298 O5' A A 10 -4.213 -7.156 -3.404 1.00 1.00 O +ATOM 299 C5' A A 10 -3.048 -6.699 -4.097 1.00 1.00 C +ATOM 300 C4' A A 10 -3.221 -6.796 -5.610 1.00 1.00 C +ATOM 301 O4' A A 10 -3.367 -8.156 -6.003 1.00 1.00 O +ATOM 302 C3' A A 10 -4.436 -6.065 -6.156 1.00 1.00 C +ATOM 303 O3' A A 10 -4.091 -4.709 -6.459 1.00 1.00 O +ATOM 304 C2' A A 10 -4.757 -6.819 -7.437 1.00 1.00 C +ATOM 305 O2' A A 10 -4.168 -6.182 -8.577 1.00 1.00 O +ATOM 306 C1' A A 10 -4.153 -8.206 -7.201 1.00 1.00 C +ATOM 307 N9 A A 10 -5.155 -9.275 -7.039 1.00 1.00 N +ATOM 308 C8 A A 10 -5.668 -9.817 -5.888 1.00 1.00 C +ATOM 309 N7 A A 10 -6.545 -10.761 -6.093 1.00 1.00 N +ATOM 310 C5 A A 10 -6.618 -10.850 -7.480 1.00 1.00 C +ATOM 311 C6 A A 10 -7.372 -11.667 -8.340 1.00 1.00 C +ATOM 312 N6 A A 10 -8.232 -12.588 -7.903 1.00 1.00 N +ATOM 313 N1 A A 10 -7.202 -11.493 -9.661 1.00 1.00 N +ATOM 314 C2 A A 10 -6.344 -10.575 -10.089 1.00 1.00 C +ATOM 315 N3 A A 10 -5.582 -9.751 -9.386 1.00 1.00 N +ATOM 316 C4 A A 10 -5.775 -9.949 -8.064 1.00 1.00 C +ATOM 317 H5' A A 10 -2.195 -7.306 -3.797 1.00 1.00 H +ATOM 318 H5'' A A 10 -2.859 -5.659 -3.827 1.00 1.00 H +ATOM 319 H4' A A 10 -2.328 -6.398 -6.089 1.00 1.00 H +ATOM 320 H3' A A 10 -5.271 -6.118 -5.454 1.00 1.00 H +ATOM 321 H2' A A 10 -5.840 -6.903 -7.558 1.00 1.00 H +ATOM 322 HO2' A A 10 -4.666 -6.462 -9.349 1.00 1.00 H +ATOM 323 H1' A A 10 -3.504 -8.457 -8.041 1.00 1.00 H +ATOM 324 H8 A A 10 -5.370 -9.488 -4.892 1.00 1.00 H +ATOM 325 H61 A A 10 -8.750 -13.153 -8.567 1.00 1.00 H +ATOM 326 H62 A A 10 -8.365 -12.726 -6.912 1.00 1.00 H +ATOM 327 H2 A A 10 -6.254 -10.487 -11.172 1.00 1.00 H +ATOM 328 P A A 11 -5.229 -3.578 -6.596 1.00 1.00 P +ATOM 329 OP1 A A 11 -4.560 -2.277 -6.819 1.00 1.00 O +ATOM 330 OP2 A A 11 -6.186 -3.737 -5.479 1.00 1.00 O +ATOM 331 O5' A A 11 -5.971 -3.988 -7.962 1.00 1.00 O +ATOM 332 C5' A A 11 -5.259 -3.938 -9.200 1.00 1.00 C +ATOM 333 C4' A A 11 -5.963 -4.731 -10.296 1.00 1.00 C +ATOM 334 O4' A A 11 -6.171 -6.081 -9.880 1.00 1.00 O +ATOM 335 C3' A A 11 -7.332 -4.193 -10.684 1.00 1.00 C +ATOM 336 O3' A A 11 -7.191 -3.222 -11.727 1.00 1.00 O +ATOM 337 C2' A A 11 -8.030 -5.415 -11.237 1.00 1.00 C +ATOM 338 O2' A A 11 -7.886 -5.504 -12.659 1.00 1.00 O +ATOM 339 C1' A A 11 -7.350 -6.582 -10.526 1.00 1.00 C +ATOM 340 N9 A A 11 -8.201 -7.270 -9.535 1.00 1.00 N +ATOM 341 C8 A A 11 -8.509 -6.916 -8.246 1.00 1.00 C +ATOM 342 N7 A A 11 -9.308 -7.754 -7.645 1.00 1.00 N +ATOM 343 C5 A A 11 -9.545 -8.734 -8.605 1.00 1.00 C +ATOM 344 C6 A A 11 -10.317 -9.907 -8.594 1.00 1.00 C +ATOM 345 N6 A A 11 -11.022 -10.307 -7.535 1.00 1.00 N +ATOM 346 N1 A A 11 -10.332 -10.646 -9.716 1.00 1.00 N +ATOM 347 C2 A A 11 -9.629 -10.243 -10.767 1.00 1.00 C +ATOM 348 N3 A A 11 -8.869 -9.166 -10.901 1.00 1.00 N +ATOM 349 C4 A A 11 -8.874 -8.446 -9.759 1.00 1.00 C +ATOM 350 H5' A A 11 -4.261 -4.348 -9.050 1.00 1.00 H +ATOM 351 H5'' A A 11 -5.173 -2.898 -9.515 1.00 1.00 H +ATOM 352 H4' A A 11 -5.327 -4.742 -11.180 1.00 1.00 H +ATOM 353 H3' A A 11 -7.860 -3.788 -9.822 1.00 1.00 H +ATOM 354 H2' A A 11 -9.088 -5.383 -10.960 1.00 1.00 H +ATOM 355 HO2' A A 11 -6.972 -5.735 -12.838 1.00 1.00 H +ATOM 356 H1' A A 11 -7.042 -7.310 -11.279 1.00 1.00 H +ATOM 357 H8 A A 11 -8.124 -6.014 -7.769 1.00 1.00 H +ATOM 358 H61 A A 11 -11.561 -11.159 -7.580 1.00 1.00 H +ATOM 359 H62 A A 11 -11.020 -9.759 -6.691 1.00 1.00 H +ATOM 360 H2 A A 11 -9.685 -10.888 -11.645 1.00 1.00 H +ATOM 361 P G A 12 -8.434 -2.294 -12.161 1.00 1.00 P +ATOM 362 OP1 G A 12 -7.940 -1.278 -13.117 1.00 1.00 O +ATOM 363 OP2 G A 12 -9.140 -1.866 -10.932 1.00 1.00 O +ATOM 364 O5' G A 12 -9.397 -3.313 -12.964 1.00 1.00 O +ATOM 365 C5' G A 12 -9.161 -3.608 -14.349 1.00 1.00 C +ATOM 366 C4' G A 12 -10.417 -4.153 -15.035 1.00 1.00 C +ATOM 367 O4' G A 12 -10.436 -5.585 -14.976 1.00 1.00 O +ATOM 368 C3' G A 12 -11.717 -3.659 -14.414 1.00 1.00 C +ATOM 369 O3' G A 12 -12.189 -2.512 -15.129 1.00 1.00 O +ATOM 370 C2' G A 12 -12.673 -4.822 -14.610 1.00 1.00 C +ATOM 371 O2' G A 12 -13.381 -4.714 -15.849 1.00 1.00 O +ATOM 372 C1' G A 12 -11.748 -6.032 -14.603 1.00 1.00 C +ATOM 373 N9 G A 12 -11.629 -6.686 -13.289 1.00 1.00 N +ATOM 374 C8 G A 12 -10.500 -6.879 -12.535 1.00 1.00 C +ATOM 375 N7 G A 12 -10.719 -7.484 -11.402 1.00 1.00 N +ATOM 376 C5 G A 12 -12.092 -7.710 -11.401 1.00 1.00 C +ATOM 377 C6 G A 12 -12.912 -8.336 -10.422 1.00 1.00 C +ATOM 378 O6 G A 12 -12.578 -8.824 -9.345 1.00 1.00 O +ATOM 379 N1 G A 12 -14.245 -8.357 -10.812 1.00 1.00 N +ATOM 380 C2 G A 12 -14.730 -7.842 -11.995 1.00 1.00 C +ATOM 381 N2 G A 12 -16.044 -7.954 -12.193 1.00 1.00 N +ATOM 382 N3 G A 12 -13.961 -7.254 -12.916 1.00 1.00 N +ATOM 383 C4 G A 12 -12.658 -7.223 -12.552 1.00 1.00 C +ATOM 384 H5' G A 12 -8.366 -4.349 -14.424 1.00 1.00 H +ATOM 385 H5'' G A 12 -8.847 -2.696 -14.858 1.00 1.00 H +ATOM 386 H4' G A 12 -10.398 -3.856 -16.081 1.00 1.00 H +ATOM 387 H3' G A 12 -11.582 -3.439 -13.352 1.00 1.00 H +ATOM 388 H2' G A 12 -13.368 -4.880 -13.769 1.00 1.00 H +ATOM 389 HO2' G A 12 -13.223 -5.524 -16.341 1.00 1.00 H +ATOM 390 H1' G A 12 -12.102 -6.763 -15.330 1.00 1.00 H +ATOM 391 H8 G A 12 -9.510 -6.555 -12.855 1.00 1.00 H +ATOM 392 H1 G A 12 -14.890 -8.788 -10.166 1.00 1.00 H +ATOM 393 H21 G A 12 -16.623 -8.398 -11.494 1.00 1.00 H +ATOM 394 H22 G A 12 -16.459 -7.595 -13.039 1.00 1.00 H +ATOM 395 P A A 13 -12.888 -1.290 -14.345 1.00 1.00 P +ATOM 396 OP1 A A 13 -12.943 -0.128 -15.260 1.00 1.00 O +ATOM 397 OP2 A A 13 -12.237 -1.157 -13.023 1.00 1.00 O +ATOM 398 O5' A A 13 -14.393 -1.820 -14.115 1.00 1.00 O +ATOM 399 C5' A A 13 -15.363 -1.719 -15.162 1.00 1.00 C +ATOM 400 C4' A A 13 -16.704 -2.324 -14.750 1.00 1.00 C +ATOM 401 O4' A A 13 -16.526 -3.702 -14.418 1.00 1.00 O +ATOM 402 C3' A A 13 -17.351 -1.652 -13.546 1.00 1.00 C +ATOM 403 O3' A A 13 -18.277 -0.652 -13.992 1.00 1.00 O +ATOM 404 C2' A A 13 -18.097 -2.789 -12.869 1.00 1.00 C +ATOM 405 O2' A A 13 -19.436 -2.905 -13.364 1.00 1.00 O +ATOM 406 C1' A A 13 -17.263 -4.012 -13.227 1.00 1.00 C +ATOM 407 N9 A A 13 -16.289 -4.389 -12.186 1.00 1.00 N +ATOM 408 C8 A A 13 -15.003 -3.948 -12.013 1.00 1.00 C +ATOM 409 N7 A A 13 -14.398 -4.475 -10.983 1.00 1.00 N +ATOM 410 C5 A A 13 -15.354 -5.328 -10.437 1.00 1.00 C +ATOM 411 C6 A A 13 -15.337 -6.183 -9.322 1.00 1.00 C +ATOM 412 N6 A A 13 -14.277 -6.324 -8.525 1.00 1.00 N +ATOM 413 N1 A A 13 -16.455 -6.883 -9.066 1.00 1.00 N +ATOM 414 C2 A A 13 -17.507 -6.737 -9.862 1.00 1.00 C +ATOM 415 N3 A A 13 -17.646 -5.970 -10.932 1.00 1.00 N +ATOM 416 C4 A A 13 -16.508 -5.280 -11.164 1.00 1.00 C +ATOM 417 H5' A A 13 -14.992 -2.244 -16.042 1.00 1.00 H +ATOM 418 H5'' A A 13 -15.508 -0.667 -15.411 1.00 1.00 H +ATOM 419 H4' A A 13 -17.388 -2.263 -15.594 1.00 1.00 H +ATOM 420 H3' A A 13 -16.594 -1.227 -12.881 1.00 1.00 H +ATOM 421 H2' A A 13 -18.096 -2.646 -11.789 1.00 1.00 H +ATOM 422 HO2' A A 13 -20.017 -2.948 -12.602 1.00 1.00 H +ATOM 423 H1' A A 13 -17.924 -4.855 -13.419 1.00 1.00 H +ATOM 424 H8 A A 13 -14.528 -3.222 -12.674 1.00 1.00 H +ATOM 425 H61 A A 13 -14.318 -6.955 -7.735 1.00 1.00 H +ATOM 426 H62 A A 13 -13.432 -5.803 -8.710 1.00 1.00 H +ATOM 427 H2 A A 13 -18.381 -7.333 -9.596 1.00 1.00 H +ATOM 428 P A A 14 -18.463 0.726 -13.175 1.00 1.00 P +ATOM 429 OP1 A A 14 -19.349 1.612 -13.963 1.00 1.00 O +ATOM 430 OP2 A A 14 -17.124 1.203 -12.763 1.00 1.00 O +ATOM 431 O5' A A 14 -19.262 0.265 -11.855 1.00 1.00 O +ATOM 432 C5' A A 14 -20.677 0.059 -11.896 1.00 1.00 C +ATOM 433 C4' A A 14 -21.216 -0.423 -10.550 1.00 1.00 C +ATOM 434 O4' A A 14 -20.666 -1.701 -10.237 1.00 1.00 O +ATOM 435 C3' A A 14 -20.888 0.485 -9.376 1.00 1.00 C +ATOM 436 O3' A A 14 -21.926 1.459 -9.207 1.00 1.00 O +ATOM 437 C2' A A 14 -20.864 -0.465 -8.191 1.00 1.00 C +ATOM 438 O2' A A 14 -22.137 -0.522 -7.541 1.00 1.00 O +ATOM 439 C1' A A 14 -20.497 -1.808 -8.815 1.00 1.00 C +ATOM 440 N9 A A 14 -19.103 -2.214 -8.563 1.00 1.00 N +ATOM 441 C8 A A 14 -17.968 -1.866 -9.249 1.00 1.00 C +ATOM 442 N7 A A 14 -16.879 -2.410 -8.779 1.00 1.00 N +ATOM 443 C5 A A 14 -17.326 -3.175 -7.705 1.00 1.00 C +ATOM 444 C6 A A 14 -16.660 -4.002 -6.786 1.00 1.00 C +ATOM 445 N6 A A 14 -15.341 -4.202 -6.806 1.00 1.00 N +ATOM 446 N1 A A 14 -17.408 -4.609 -5.849 1.00 1.00 N +ATOM 447 C2 A A 14 -18.720 -4.406 -5.834 1.00 1.00 C +ATOM 448 N3 A A 14 -19.459 -3.657 -6.639 1.00 1.00 N +ATOM 449 C4 A A 14 -18.680 -3.061 -7.567 1.00 1.00 C +ATOM 450 H5' A A 14 -20.905 -0.687 -12.658 1.00 1.00 H +ATOM 451 H5'' A A 14 -21.165 0.997 -12.160 1.00 1.00 H +ATOM 452 H4' A A 14 -22.297 -0.527 -10.624 1.00 1.00 H +ATOM 453 H3' A A 14 -19.915 0.960 -9.514 1.00 1.00 H +ATOM 454 H2' A A 14 -20.085 -0.162 -7.491 1.00 1.00 H +ATOM 455 HO2' A A 14 -22.432 -1.435 -7.569 1.00 1.00 H +ATOM 456 H1' A A 14 -21.165 -2.576 -8.431 1.00 1.00 H +ATOM 457 H8 A A 14 -17.974 -1.192 -10.106 1.00 1.00 H +ATOM 458 H61 A A 14 -14.916 -4.804 -6.127 1.00 1.00 H +ATOM 459 H62 A A 14 -14.772 -3.749 -7.508 1.00 1.00 H +ATOM 460 H2 A A 14 -19.265 -4.927 -5.048 1.00 1.00 H +ATOM 461 P C A 15 -21.664 2.797 -8.347 1.00 1.00 P +ATOM 462 OP1 C A 15 -22.828 3.695 -8.522 1.00 1.00 O +ATOM 463 OP2 C A 15 -20.303 3.287 -8.655 1.00 1.00 O +ATOM 464 O5' C A 15 -21.673 2.258 -6.826 1.00 1.00 O +ATOM 465 C5' C A 15 -22.910 1.996 -6.153 1.00 1.00 C +ATOM 466 C4' C A 15 -22.687 1.364 -4.779 1.00 1.00 C +ATOM 467 O4' C A 15 -21.878 0.197 -4.899 1.00 1.00 O +ATOM 468 C3' C A 15 -21.981 2.263 -3.779 1.00 1.00 C +ATOM 469 O3' C A 15 -22.938 3.052 -3.067 1.00 1.00 O +ATOM 470 C2' C A 15 -21.319 1.275 -2.830 1.00 1.00 C +ATOM 471 O2' C A 15 -22.156 0.998 -1.701 1.00 1.00 O +ATOM 472 C1' C A 15 -21.117 0.026 -3.691 1.00 1.00 C +ATOM 473 N1 C A 15 -19.710 -0.211 -4.081 1.00 1.00 N +ATOM 474 C2 C A 15 -18.972 -1.117 -3.334 1.00 1.00 C +ATOM 475 O2 C A 15 -19.492 -1.697 -2.383 1.00 1.00 O +ATOM 476 N3 C A 15 -17.674 -1.337 -3.683 1.00 1.00 N +ATOM 477 C4 C A 15 -17.124 -0.696 -4.724 1.00 1.00 C +ATOM 478 N4 C A 15 -15.850 -0.933 -5.040 1.00 1.00 N +ATOM 479 C5 C A 15 -17.882 0.238 -5.497 1.00 1.00 C +ATOM 480 C6 C A 15 -19.164 0.449 -5.143 1.00 1.00 C +ATOM 481 H5' C A 15 -23.509 1.318 -6.762 1.00 1.00 H +ATOM 482 H5'' C A 15 -23.452 2.934 -6.028 1.00 1.00 H +ATOM 483 H4' C A 15 -23.652 1.070 -4.368 1.00 1.00 H +ATOM 484 H3' C A 15 -21.236 2.888 -4.275 1.00 1.00 H +ATOM 485 H2' C A 15 -20.352 1.661 -2.507 1.00 1.00 H +ATOM 486 HO2' C A 15 -22.354 0.058 -1.716 1.00 1.00 H +ATOM 487 H1' C A 15 -21.492 -0.842 -3.152 1.00 1.00 H +ATOM 488 H41 C A 15 -15.309 -1.591 -4.497 1.00 1.00 H +ATOM 489 H42 C A 15 -15.426 -0.454 -5.821 1.00 1.00 H +ATOM 490 H5 C A 15 -17.438 0.760 -6.345 1.00 1.00 H +ATOM 491 H6 C A 15 -19.772 1.154 -5.711 1.00 1.00 H +ATOM 492 P C A 16 -22.507 4.462 -2.417 1.00 1.00 P +ATOM 493 OP1 C A 16 -23.687 5.033 -1.727 1.00 1.00 O +ATOM 494 OP2 C A 16 -21.801 5.252 -3.448 1.00 1.00 O +ATOM 495 O5' C A 16 -21.436 4.016 -1.297 1.00 1.00 O +ATOM 496 C5' C A 16 -21.848 3.247 -0.164 1.00 1.00 C +ATOM 497 C4' C A 16 -20.673 2.514 0.481 1.00 1.00 C +ATOM 498 O4' C A 16 -19.988 1.742 -0.501 1.00 1.00 O +ATOM 499 C3' C A 16 -19.627 3.421 1.112 1.00 1.00 C +ATOM 500 O3' C A 16 -19.939 3.628 2.496 1.00 1.00 O +ATOM 501 C2' C A 16 -18.344 2.614 1.007 1.00 1.00 C +ATOM 502 O2' C A 16 -18.040 1.952 2.240 1.00 1.00 O +ATOM 503 C1' C A 16 -18.614 1.613 -0.113 1.00 1.00 C +ATOM 504 N1 C A 16 -17.758 1.802 -1.307 1.00 1.00 N +ATOM 505 C2 C A 16 -16.655 0.974 -1.429 1.00 1.00 C +ATOM 506 O2 C A 16 -16.418 0.132 -0.565 1.00 1.00 O +ATOM 507 N3 C A 16 -15.852 1.123 -2.519 1.00 1.00 N +ATOM 508 C4 C A 16 -16.122 2.047 -3.450 1.00 1.00 C +ATOM 509 N4 C A 16 -15.316 2.163 -4.506 1.00 1.00 N +ATOM 510 C5 C A 16 -17.259 2.906 -3.328 1.00 1.00 C +ATOM 511 C6 C A 16 -18.046 2.752 -2.246 1.00 1.00 C +ATOM 512 H5' C A 16 -22.593 2.517 -0.482 1.00 1.00 H +ATOM 513 H5'' C A 16 -22.297 3.914 0.572 1.00 1.00 H +ATOM 514 H4' C A 16 -21.057 1.836 1.242 1.00 1.00 H +ATOM 515 H3' C A 16 -19.545 4.366 0.572 1.00 1.00 H +ATOM 516 H2' C A 16 -17.528 3.274 0.713 1.00 1.00 H +ATOM 517 HO2' C A 16 -17.685 1.086 2.020 1.00 1.00 H +ATOM 518 H1' C A 16 -18.462 0.606 0.279 1.00 1.00 H +ATOM 519 H41 C A 16 -14.509 1.559 -4.597 1.00 1.00 H +ATOM 520 H42 C A 16 -15.509 2.858 -5.214 1.00 1.00 H +ATOM 521 H5 C A 16 -17.480 3.660 -4.085 1.00 1.00 H +ATOM 522 H6 C A 16 -18.920 3.391 -2.117 1.00 1.00 H +ATOM 523 P G A 17 -19.137 4.723 3.365 1.00 1.00 P +ATOM 524 OP1 G A 17 -19.981 5.097 4.522 1.00 1.00 O +ATOM 525 OP2 G A 17 -18.644 5.772 2.445 1.00 1.00 O +ATOM 526 O5' G A 17 -17.863 3.897 3.916 1.00 1.00 O +ATOM 527 C5' G A 17 -18.023 2.880 4.914 1.00 1.00 C +ATOM 528 C4' G A 17 -16.680 2.290 5.354 1.00 1.00 C +ATOM 529 O4' G A 17 -16.077 1.573 4.279 1.00 1.00 O +ATOM 530 C3' G A 17 -15.655 3.317 5.809 1.00 1.00 C +ATOM 531 O3' G A 17 -15.794 3.560 7.212 1.00 1.00 O +ATOM 532 C2' G A 17 -14.325 2.636 5.532 1.00 1.00 C +ATOM 533 O2' G A 17 -13.838 1.953 6.692 1.00 1.00 O +ATOM 534 C1' G A 17 -14.649 1.655 4.409 1.00 1.00 C +ATOM 535 N9 G A 17 -14.110 2.059 3.103 1.00 1.00 N +ATOM 536 C8 G A 17 -14.777 2.588 2.029 1.00 1.00 C +ATOM 537 N7 G A 17 -14.012 2.846 1.005 1.00 1.00 N +ATOM 538 C5 G A 17 -12.745 2.460 1.427 1.00 1.00 C +ATOM 539 C6 G A 17 -11.501 2.506 0.738 1.00 1.00 C +ATOM 540 O6 G A 17 -11.276 2.906 -0.403 1.00 1.00 O +ATOM 541 N1 G A 17 -10.465 2.022 1.523 1.00 1.00 N +ATOM 542 C2 G A 17 -10.601 1.552 2.811 1.00 1.00 C +ATOM 543 N2 G A 17 -9.484 1.131 3.405 1.00 1.00 N +ATOM 544 N3 G A 17 -11.768 1.506 3.463 1.00 1.00 N +ATOM 545 C4 G A 17 -12.793 1.976 2.712 1.00 1.00 C +ATOM 546 H5' G A 17 -18.645 2.081 4.510 1.00 1.00 H +ATOM 547 H5'' G A 17 -18.521 3.310 5.784 1.00 1.00 H +ATOM 548 H4' G A 17 -16.859 1.591 6.169 1.00 1.00 H +ATOM 549 H3' G A 17 -15.748 4.239 5.233 1.00 1.00 H +ATOM 550 H2' G A 17 -13.597 3.374 5.184 1.00 1.00 H +ATOM 551 HO2' G A 17 -13.454 1.125 6.393 1.00 1.00 H +ATOM 552 H1' G A 17 -14.255 0.672 4.666 1.00 1.00 H +ATOM 553 H8 G A 17 -15.851 2.778 2.031 1.00 1.00 H +ATOM 554 H1 G A 17 -9.548 2.025 1.099 1.00 1.00 H +ATOM 555 H21 G A 17 -8.605 1.168 2.908 1.00 1.00 H +ATOM 556 H22 G A 17 -9.518 0.775 4.348 1.00 1.00 H +ATOM 557 P G A 18 -15.191 4.898 7.874 1.00 1.00 P +ATOM 558 OP1 G A 18 -15.552 4.910 9.309 1.00 1.00 O +ATOM 559 OP2 G A 18 -15.554 6.045 7.012 1.00 1.00 O +ATOM 560 O5' G A 18 -13.600 4.662 7.755 1.00 1.00 O +ATOM 561 C5' G A 18 -12.972 3.581 8.453 1.00 1.00 C +ATOM 562 C4' G A 18 -11.476 3.502 8.153 1.00 1.00 C +ATOM 563 O4' G A 18 -11.265 3.233 6.771 1.00 1.00 O +ATOM 564 C3' G A 18 -10.703 4.774 8.461 1.00 1.00 C +ATOM 565 O3' G A 18 -10.239 4.733 9.816 1.00 1.00 O +ATOM 566 C2' G A 18 -9.525 4.719 7.501 1.00 1.00 C +ATOM 567 O2' G A 18 -8.362 4.174 8.133 1.00 1.00 O +ATOM 568 C1' G A 18 -10.017 3.814 6.368 1.00 1.00 C +ATOM 569 N9 G A 18 -10.241 4.521 5.091 1.00 1.00 N +ATOM 570 C8 G A 18 -11.365 5.175 4.655 1.00 1.00 C +ATOM 571 N7 G A 18 -11.243 5.702 3.469 1.00 1.00 N +ATOM 572 C5 G A 18 -9.946 5.374 3.088 1.00 1.00 C +ATOM 573 C6 G A 18 -9.244 5.679 1.887 1.00 1.00 C +ATOM 574 O6 G A 18 -9.642 6.311 0.911 1.00 1.00 O +ATOM 575 N1 G A 18 -7.956 5.163 1.905 1.00 1.00 N +ATOM 576 C2 G A 18 -7.407 4.443 2.944 1.00 1.00 C +ATOM 577 N2 G A 18 -6.152 4.029 2.776 1.00 1.00 N +ATOM 578 N3 G A 18 -8.064 4.154 4.073 1.00 1.00 N +ATOM 579 C4 G A 18 -9.324 4.651 4.075 1.00 1.00 C +ATOM 580 H5' G A 18 -13.444 2.645 8.154 1.00 1.00 H +ATOM 581 H5'' G A 18 -13.112 3.721 9.525 1.00 1.00 H +ATOM 582 H4' G A 18 -11.047 2.683 8.728 1.00 1.00 H +ATOM 583 H3' G A 18 -11.318 5.657 8.277 1.00 1.00 H +ATOM 584 H2' G A 18 -9.319 5.718 7.111 1.00 1.00 H +ATOM 585 HO2' G A 18 -8.284 3.261 7.847 1.00 1.00 H +ATOM 586 H1' G A 18 -9.291 3.019 6.207 1.00 1.00 H +ATOM 587 H8 G A 18 -12.278 5.246 5.247 1.00 1.00 H +ATOM 588 H1 G A 18 -7.395 5.340 1.084 1.00 1.00 H +ATOM 589 H21 G A 18 -5.657 4.248 1.922 1.00 1.00 H +ATOM 590 H22 G A 18 -5.693 3.497 3.501 1.00 1.00 H +ATOM 591 P G A 19 -9.661 6.057 10.530 1.00 1.00 P +ATOM 592 OP1 G A 19 -9.563 5.794 11.984 1.00 1.00 O +ATOM 593 OP2 G A 19 -10.432 7.222 10.042 1.00 1.00 O +ATOM 594 O5' G A 19 -8.168 6.154 9.936 1.00 1.00 O +ATOM 595 C5' G A 19 -7.211 5.124 10.207 1.00 1.00 C +ATOM 596 C4' G A 19 -5.962 5.271 9.342 1.00 1.00 C +ATOM 597 O4' G A 19 -6.328 5.269 7.965 1.00 1.00 O +ATOM 598 C3' G A 19 -5.182 6.552 9.592 1.00 1.00 C +ATOM 599 O3' G A 19 -4.156 6.301 10.560 1.00 1.00 O +ATOM 600 C2' G A 19 -4.556 6.866 8.240 1.00 1.00 C +ATOM 601 O2' G A 19 -3.220 6.357 8.157 1.00 1.00 O +ATOM 602 C1' G A 19 -5.480 6.171 7.239 1.00 1.00 C +ATOM 603 N9 G A 19 -6.356 7.093 6.493 1.00 1.00 N +ATOM 604 C8 G A 19 -7.553 7.639 6.882 1.00 1.00 C +ATOM 605 N7 G A 19 -8.088 8.427 5.994 1.00 1.00 N +ATOM 606 C5 G A 19 -7.184 8.406 4.937 1.00 1.00 C +ATOM 607 C6 G A 19 -7.232 9.077 3.684 1.00 1.00 C +ATOM 608 O6 G A 19 -8.099 9.836 3.257 1.00 1.00 O +ATOM 609 N1 G A 19 -6.119 8.783 2.905 1.00 1.00 N +ATOM 610 C2 G A 19 -5.089 7.949 3.283 1.00 1.00 C +ATOM 611 N2 G A 19 -4.106 7.790 2.398 1.00 1.00 N +ATOM 612 N3 G A 19 -5.042 7.316 4.460 1.00 1.00 N +ATOM 613 C4 G A 19 -6.119 7.591 5.233 1.00 1.00 C +ATOM 614 H5' G A 19 -7.669 4.155 10.009 1.00 1.00 H +ATOM 615 H5'' G A 19 -6.925 5.173 11.257 1.00 1.00 H +ATOM 616 H4' G A 19 -5.308 4.421 9.524 1.00 1.00 H +ATOM 617 H3' G A 19 -5.845 7.358 9.912 1.00 1.00 H +ATOM 618 H2' G A 19 -4.568 7.945 8.068 1.00 1.00 H +ATOM 619 HO2' G A 19 -2.774 6.592 8.973 1.00 1.00 H +ATOM 620 H1' G A 19 -4.878 5.603 6.529 1.00 1.00 H +ATOM 621 H8 G A 19 -8.014 7.431 7.848 1.00 1.00 H +ATOM 622 H1 G A 19 -6.083 9.225 1.998 1.00 1.00 H +ATOM 623 H21 G A 19 -4.143 8.268 1.511 1.00 1.00 H +ATOM 624 H22 G A 19 -3.323 7.190 2.616 1.00 1.00 H +ATOM 625 P G A 20 -3.709 7.443 11.603 1.00 1.00 P +ATOM 626 OP1 G A 20 -2.841 6.819 12.626 1.00 1.00 O +ATOM 627 OP2 G A 20 -4.917 8.191 12.016 1.00 1.00 O +ATOM 628 O5' G A 20 -2.800 8.417 10.698 1.00 1.00 O +ATOM 629 C5' G A 20 -2.763 9.821 10.965 1.00 1.00 C +ATOM 630 C4' G A 20 -2.231 10.609 9.770 1.00 1.00 C +ATOM 631 O4' G A 20 -2.728 10.042 8.554 1.00 1.00 O +ATOM 632 C3' G A 20 -2.617 12.084 9.779 1.00 1.00 C +ATOM 633 O3' G A 20 -1.530 12.854 10.302 1.00 1.00 O +ATOM 634 C2' G A 20 -2.826 12.418 8.310 1.00 1.00 C +ATOM 635 O2' G A 20 -1.629 12.930 7.715 1.00 1.00 O +ATOM 636 C1' G A 20 -3.223 11.079 7.697 1.00 1.00 C +ATOM 637 N9 G A 20 -4.678 10.882 7.576 1.00 1.00 N +ATOM 638 C8 G A 20 -5.545 10.350 8.494 1.00 1.00 C +ATOM 639 N7 G A 20 -6.785 10.320 8.096 1.00 1.00 N +ATOM 640 C5 G A 20 -6.742 10.872 6.820 1.00 1.00 C +ATOM 641 C6 G A 20 -7.795 11.099 5.892 1.00 1.00 C +ATOM 642 O6 G A 20 -8.992 10.855 6.023 1.00 1.00 O +ATOM 643 N1 G A 20 -7.327 11.674 4.720 1.00 1.00 N +ATOM 644 C2 G A 20 -6.011 11.993 4.467 1.00 1.00 C +ATOM 645 N2 G A 20 -5.758 12.539 3.277 1.00 1.00 N +ATOM 646 N3 G A 20 -5.015 11.781 5.338 1.00 1.00 N +ATOM 647 C4 G A 20 -5.455 11.220 6.490 1.00 1.00 C +ATOM 648 H5' G A 20 -2.118 10.002 11.825 1.00 1.00 H +ATOM 649 H5'' G A 20 -3.770 10.163 11.201 1.00 1.00 H +ATOM 650 H4' G A 20 -1.146 10.534 9.760 1.00 1.00 H +ATOM 651 H3' G A 20 -3.532 12.248 10.350 1.00 1.00 H +ATOM 652 H2' G A 20 -3.648 13.132 8.205 1.00 1.00 H +ATOM 653 HO2' G A 20 -1.583 13.866 7.924 1.00 1.00 H +ATOM 654 H1' G A 20 -2.767 10.982 6.713 1.00 1.00 H +ATOM 655 H8 G A 20 -5.225 9.981 9.468 1.00 1.00 H +ATOM 656 H1 G A 20 -8.020 11.867 4.011 1.00 1.00 H +ATOM 657 H21 G A 20 -6.510 12.697 2.622 1.00 1.00 H +ATOM 658 H22 G A 20 -4.814 12.793 3.031 1.00 1.00 H +ATOM 659 P A A 21 -1.774 13.913 11.493 1.00 1.00 P +ATOM 660 OP1 A A 21 -0.526 14.683 11.688 1.00 1.00 O +ATOM 661 OP2 A A 21 -2.385 13.197 12.634 1.00 1.00 O +ATOM 662 O5' A A 21 -2.881 14.901 10.868 1.00 1.00 O +ATOM 663 C5' A A 21 -4.054 15.252 11.609 1.00 1.00 C +ATOM 664 C4' A A 21 -4.824 16.382 10.928 1.00 1.00 C +ATOM 665 O4' A A 21 -4.116 17.616 11.105 1.00 1.00 O +ATOM 666 C3' A A 21 -5.020 16.166 9.428 1.00 1.00 C +ATOM 667 O3' A A 21 -6.392 15.861 9.155 1.00 1.00 O +ATOM 668 C2' A A 21 -4.663 17.502 8.797 1.00 1.00 C +ATOM 669 O2' A A 21 -5.830 18.294 8.552 1.00 1.00 O +ATOM 670 C1' A A 21 -3.758 18.152 9.829 1.00 1.00 C +ATOM 671 N9 A A 21 -2.322 17.884 9.620 1.00 1.00 N +ATOM 672 C8 A A 21 -1.493 17.075 10.351 1.00 1.00 C +ATOM 673 N7 A A 21 -0.265 17.044 9.913 1.00 1.00 N +ATOM 674 C5 A A 21 -0.283 17.894 8.811 1.00 1.00 C +ATOM 675 C6 A A 21 0.711 18.294 7.902 1.00 1.00 C +ATOM 676 N6 A A 21 1.972 17.867 7.963 1.00 1.00 N +ATOM 677 N1 A A 21 0.348 19.149 6.932 1.00 1.00 N +ATOM 678 C2 A A 21 -0.909 19.570 6.874 1.00 1.00 C +ATOM 679 N3 A A 21 -1.927 19.268 7.664 1.00 1.00 N +ATOM 680 C4 A A 21 -1.534 18.411 8.627 1.00 1.00 C +ATOM 681 H5' A A 21 -3.762 15.572 12.609 1.00 1.00 H +ATOM 682 H5'' A A 21 -4.701 14.377 11.687 1.00 1.00 H +ATOM 683 H4' A A 21 -5.800 16.475 11.399 1.00 1.00 H +ATOM 684 H3' A A 21 -4.362 15.376 9.062 1.00 1.00 H +ATOM 685 H2' A A 21 -4.107 17.337 7.874 1.00 1.00 H +ATOM 686 HO2' A A 21 -6.074 18.166 7.633 1.00 1.00 H +ATOM 687 H1' A A 21 -3.925 19.228 9.829 1.00 1.00 H +ATOM 688 H8 A A 21 -1.829 16.508 11.221 1.00 1.00 H +ATOM 689 H61 A A 21 2.648 18.186 7.284 1.00 1.00 H +ATOM 690 H62 A A 21 2.251 17.224 8.691 1.00 1.00 H +ATOM 691 H2 A A 21 -1.134 20.262 6.063 1.00 1.00 H +ATOM 692 P A A 22 -6.776 14.720 8.082 1.00 1.00 P +ATOM 693 OP1 A A 22 -8.251 14.637 8.004 1.00 1.00 O +ATOM 694 OP2 A A 22 -5.985 13.510 8.395 1.00 1.00 O +ATOM 695 O5' A A 22 -6.231 15.332 6.693 1.00 1.00 O +ATOM 696 C5' A A 22 -7.060 16.183 5.893 1.00 1.00 C +ATOM 697 C4' A A 22 -6.289 17.407 5.393 1.00 1.00 C +ATOM 698 O4' A A 22 -5.128 17.594 6.203 1.00 1.00 O +ATOM 699 C3' A A 22 -5.817 17.302 3.946 1.00 1.00 C +ATOM 700 O3' A A 22 -6.724 18.007 3.089 1.00 1.00 O +ATOM 701 C2' A A 22 -4.471 18.006 3.948 1.00 1.00 C +ATOM 702 O2' A A 22 -4.609 19.397 3.635 1.00 1.00 O +ATOM 703 C1' A A 22 -3.980 17.801 5.372 1.00 1.00 C +ATOM 704 N9 A A 22 -3.099 16.634 5.533 1.00 1.00 N +ATOM 705 C8 A A 22 -3.315 15.487 6.253 1.00 1.00 C +ATOM 706 N7 A A 22 -2.322 14.642 6.211 1.00 1.00 N +ATOM 707 C5 A A 22 -1.381 15.274 5.405 1.00 1.00 C +ATOM 708 C6 A A 22 -0.099 14.900 4.968 1.00 1.00 C +ATOM 709 N6 A A 22 0.476 13.743 5.301 1.00 1.00 N +ATOM 710 N1 A A 22 0.560 15.764 4.179 1.00 1.00 N +ATOM 711 C2 A A 22 -0.017 16.913 3.852 1.00 1.00 C +ATOM 712 N3 A A 22 -1.210 17.377 4.196 1.00 1.00 N +ATOM 713 C4 A A 22 -1.846 16.489 4.988 1.00 1.00 C +ATOM 714 H5' A A 22 -7.910 16.514 6.489 1.00 1.00 H +ATOM 715 H5'' A A 22 -7.425 15.617 5.035 1.00 1.00 H +ATOM 716 H4' A A 22 -6.919 18.289 5.494 1.00 1.00 H +ATOM 717 H3' A A 22 -5.713 16.258 3.644 1.00 1.00 H +ATOM 718 H2' A A 22 -3.793 17.514 3.245 1.00 1.00 H +ATOM 719 HO2' A A 22 -5.536 19.622 3.740 1.00 1.00 H +ATOM 720 H1' A A 22 -3.450 18.692 5.709 1.00 1.00 H +ATOM 721 H8 A A 22 -4.234 15.297 6.809 1.00 1.00 H +ATOM 722 H61 A A 22 1.400 13.523 4.959 1.00 1.00 H +ATOM 723 H62 A A 22 -0.013 13.089 5.894 1.00 1.00 H +ATOM 724 H2 A A 22 0.571 17.567 3.208 1.00 1.00 H +ATOM 725 P A A 23 -7.321 17.303 1.768 1.00 1.00 P +ATOM 726 OP1 A A 23 -8.203 18.276 1.085 1.00 1.00 O +ATOM 727 OP2 A A 23 -7.848 15.974 2.151 1.00 1.00 O +ATOM 728 O5' A A 23 -6.012 17.082 0.854 1.00 1.00 O +ATOM 729 C5' A A 23 -5.780 17.903 -0.296 1.00 1.00 C +ATOM 730 C4' A A 23 -4.356 17.744 -0.823 1.00 1.00 C +ATOM 731 O4' A A 23 -3.442 17.718 0.276 1.00 1.00 O +ATOM 732 C3' A A 23 -4.127 16.471 -1.632 1.00 1.00 C +ATOM 733 O3' A A 23 -4.228 16.763 -3.030 1.00 1.00 O +ATOM 734 C2' A A 23 -2.698 16.081 -1.292 1.00 1.00 C +ATOM 735 O2' A A 23 -1.763 16.667 -2.207 1.00 1.00 O +ATOM 736 C1' A A 23 -2.522 16.632 0.114 1.00 1.00 C +ATOM 737 N9 A A 23 -2.800 15.647 1.171 1.00 1.00 N +ATOM 738 C8 A A 23 -3.991 15.355 1.784 1.00 1.00 C +ATOM 739 N7 A A 23 -3.905 14.412 2.683 1.00 1.00 N +ATOM 740 C5 A A 23 -2.558 14.057 2.664 1.00 1.00 C +ATOM 741 C6 A A 23 -1.815 13.110 3.388 1.00 1.00 C +ATOM 742 N6 A A 23 -2.349 12.309 4.311 1.00 1.00 N +ATOM 743 N1 A A 23 -0.502 13.023 3.118 1.00 1.00 N +ATOM 744 C2 A A 23 0.025 13.818 2.196 1.00 1.00 C +ATOM 745 N3 A A 23 -0.565 14.740 1.453 1.00 1.00 N +ATOM 746 C4 A A 23 -1.880 14.806 1.746 1.00 1.00 C +ATOM 747 H5' A A 23 -5.945 18.947 -0.028 1.00 1.00 H +ATOM 748 H5'' A A 23 -6.483 17.622 -1.081 1.00 1.00 H +ATOM 749 H4' A A 23 -4.115 18.603 -1.445 1.00 1.00 H +ATOM 750 H3' A A 23 -4.827 15.688 -1.336 1.00 1.00 H +ATOM 751 H2' A A 23 -2.601 14.993 -1.279 1.00 1.00 H +ATOM 752 HO2' A A 23 -1.397 17.444 -1.780 1.00 1.00 H +ATOM 753 H1' A A 23 -1.504 17.001 0.230 1.00 1.00 H +ATOM 754 H8 A A 23 -4.926 15.862 1.541 1.00 1.00 H +ATOM 755 H61 A A 23 -1.766 11.646 4.802 1.00 1.00 H +ATOM 756 H62 A A 23 -3.341 12.366 4.524 1.00 1.00 H +ATOM 757 H2 A A 23 1.094 13.693 2.027 1.00 1.00 H +ATOM 758 P C A 24 -4.992 15.755 -4.027 1.00 1.00 P +ATOM 759 OP1 C A 24 -4.645 16.129 -5.417 1.00 1.00 O +ATOM 760 OP2 C A 24 -6.413 15.685 -3.617 1.00 1.00 O +ATOM 761 O5' C A 24 -4.303 14.336 -3.702 1.00 1.00 O +ATOM 762 C5' C A 24 -2.921 14.113 -3.998 1.00 1.00 C +ATOM 763 C4' C A 24 -2.404 12.839 -3.334 1.00 1.00 C +ATOM 764 O4' C A 24 -2.627 12.899 -1.925 1.00 1.00 O +ATOM 765 C3' C A 24 -3.068 11.562 -3.821 1.00 1.00 C +ATOM 766 O3' C A 24 -2.336 11.022 -4.926 1.00 1.00 O +ATOM 767 C2' C A 24 -2.964 10.636 -2.625 1.00 1.00 C +ATOM 768 O2' C A 24 -1.756 9.868 -2.662 1.00 1.00 O +ATOM 769 C1' C A 24 -2.978 11.594 -1.442 1.00 1.00 C +ATOM 770 N1 C A 24 -4.293 11.698 -0.782 1.00 1.00 N +ATOM 771 C2 C A 24 -4.598 10.757 0.188 1.00 1.00 C +ATOM 772 O2 C A 24 -3.790 9.870 0.460 1.00 1.00 O +ATOM 773 N3 C A 24 -5.802 10.844 0.817 1.00 1.00 N +ATOM 774 C4 C A 24 -6.670 11.815 0.509 1.00 1.00 C +ATOM 775 N4 C A 24 -7.842 11.874 1.144 1.00 1.00 N +ATOM 776 C5 C A 24 -6.360 12.790 -0.493 1.00 1.00 C +ATOM 777 C6 C A 24 -5.166 12.695 -1.109 1.00 1.00 C +ATOM 778 H5' C A 24 -2.339 14.962 -3.640 1.00 1.00 H +ATOM 779 H5'' C A 24 -2.797 14.025 -5.077 1.00 1.00 H +ATOM 780 H4' C A 24 -1.332 12.766 -3.505 1.00 1.00 H +ATOM 781 H3' C A 24 -4.112 11.742 -4.085 1.00 1.00 H +ATOM 782 H2' C A 24 -3.835 9.985 -2.581 1.00 1.00 H +ATOM 783 HO2' C A 24 -1.688 9.403 -1.825 1.00 1.00 H +ATOM 784 H1' C A 24 -2.240 11.270 -0.712 1.00 1.00 H +ATOM 785 H41 C A 24 -8.067 11.189 1.853 1.00 1.00 H +ATOM 786 H42 C A 24 -8.503 12.604 0.918 1.00 1.00 H +ATOM 787 H5 C A 24 -7.065 13.582 -0.747 1.00 1.00 H +ATOM 788 H6 C A 24 -4.895 13.420 -1.877 1.00 1.00 H +ATOM 789 P U A 25 -3.035 9.990 -5.947 1.00 1.00 P +ATOM 790 OP1 U A 25 -2.079 9.700 -7.039 1.00 1.00 O +ATOM 791 OP2 U A 25 -4.388 10.498 -6.265 1.00 1.00 O +ATOM 792 O5' U A 25 -3.193 8.660 -5.050 1.00 1.00 O +ATOM 793 C5' U A 25 -2.044 8.042 -4.463 1.00 1.00 C +ATOM 794 C4' U A 25 -2.430 7.037 -3.378 1.00 1.00 C +ATOM 795 O4' U A 25 -3.231 7.672 -2.385 1.00 1.00 O +ATOM 796 C3' U A 25 -3.234 5.847 -3.875 1.00 1.00 C +ATOM 797 O3' U A 25 -2.350 4.783 -4.250 1.00 1.00 O +ATOM 798 C2' U A 25 -4.042 5.432 -2.657 1.00 1.00 C +ATOM 799 O2' U A 25 -3.400 4.371 -1.946 1.00 1.00 O +ATOM 800 C1' U A 25 -4.119 6.702 -1.809 1.00 1.00 C +ATOM 801 N1 U A 25 -5.468 7.302 -1.758 1.00 1.00 N +ATOM 802 C2 U A 25 -6.303 6.932 -0.719 1.00 1.00 C +ATOM 803 O2 U A 25 -5.957 6.124 0.140 1.00 1.00 O +ATOM 804 N3 U A 25 -7.553 7.524 -0.703 1.00 1.00 N +ATOM 805 C4 U A 25 -8.035 8.441 -1.622 1.00 1.00 C +ATOM 806 O4 U A 25 -9.168 8.905 -1.509 1.00 1.00 O +ATOM 807 C5 U A 25 -7.096 8.770 -2.672 1.00 1.00 C +ATOM 808 C6 U A 25 -5.865 8.204 -2.708 1.00 1.00 C +ATOM 809 H5' U A 25 -1.413 8.815 -4.023 1.00 1.00 H +ATOM 810 H5'' U A 25 -1.481 7.526 -5.241 1.00 1.00 H +ATOM 811 H4' U A 25 -1.522 6.672 -2.901 1.00 1.00 H +ATOM 812 H3' U A 25 -3.888 6.133 -4.701 1.00 1.00 H +ATOM 813 H2' U A 25 -5.043 5.139 -2.965 1.00 1.00 H +ATOM 814 HO2' U A 25 -3.039 4.746 -1.140 1.00 1.00 H +ATOM 815 H1' U A 25 -3.789 6.474 -0.796 1.00 1.00 H +ATOM 816 H3 U A 25 -8.173 7.262 0.049 1.00 1.00 H +ATOM 817 H5 U A 25 -7.383 9.483 -3.444 1.00 1.00 H +ATOM 818 H6 U A 25 -5.179 8.469 -3.511 1.00 1.00 H +ATOM 819 P U A 26 -2.863 3.576 -5.190 1.00 1.00 P +ATOM 820 OP1 U A 26 -1.683 2.952 -5.827 1.00 1.00 O +ATOM 821 OP2 U A 26 -3.970 4.084 -6.031 1.00 1.00 O +ATOM 822 O5' U A 26 -3.478 2.525 -4.130 1.00 1.00 O +ATOM 823 C5' U A 26 -2.644 1.918 -3.135 1.00 1.00 C +ATOM 824 C4' U A 26 -3.465 1.314 -1.995 1.00 1.00 C +ATOM 825 O4' U A 26 -4.230 2.329 -1.348 1.00 1.00 O +ATOM 826 C3' U A 26 -4.460 0.251 -2.427 1.00 1.00 C +ATOM 827 O3' U A 26 -3.833 -1.041 -2.429 1.00 1.00 O +ATOM 828 C2' U A 26 -5.530 0.323 -1.345 1.00 1.00 C +ATOM 829 O2' U A 26 -5.266 -0.585 -0.274 1.00 1.00 O +ATOM 830 C1' U A 26 -5.458 1.760 -0.860 1.00 1.00 C +ATOM 831 N1 U A 26 -6.572 2.586 -1.356 1.00 1.00 N +ATOM 832 C2 U A 26 -7.671 2.764 -0.537 1.00 1.00 C +ATOM 833 O2 U A 26 -7.746 2.248 0.575 1.00 1.00 O +ATOM 834 N3 U A 26 -8.683 3.558 -1.043 1.00 1.00 N +ATOM 835 C4 U A 26 -8.693 4.180 -2.282 1.00 1.00 C +ATOM 836 O4 U A 26 -9.651 4.866 -2.630 1.00 1.00 O +ATOM 837 C5 U A 26 -7.506 3.939 -3.070 1.00 1.00 C +ATOM 838 C6 U A 26 -6.500 3.166 -2.595 1.00 1.00 C +ATOM 839 H5' U A 26 -1.973 2.673 -2.727 1.00 1.00 H +ATOM 840 H5'' U A 26 -2.051 1.131 -3.602 1.00 1.00 H +ATOM 841 H4' U A 26 -2.784 0.880 -1.263 1.00 1.00 H +ATOM 842 H3' U A 26 -4.882 0.491 -3.406 1.00 1.00 H +ATOM 843 H2' U A 26 -6.510 0.142 -1.784 1.00 1.00 H +ATOM 844 HO2' U A 26 -4.343 -0.479 -0.035 1.00 1.00 H +ATOM 845 H1' U A 26 -5.455 1.776 0.229 1.00 1.00 H +ATOM 846 H3 U A 26 -9.494 3.697 -0.456 1.00 1.00 H +ATOM 847 H5 U A 26 -7.419 4.382 -4.062 1.00 1.00 H +ATOM 848 H6 U A 26 -5.615 3.002 -3.210 1.00 1.00 H +ATOM 849 P G A 27 -4.470 -2.265 -3.268 1.00 1.00 P +ATOM 850 OP1 G A 27 -3.532 -3.409 -3.218 1.00 1.00 O +ATOM 851 OP2 G A 27 -4.927 -1.739 -4.571 1.00 1.00 O +ATOM 852 O5' G A 27 -5.767 -2.635 -2.396 1.00 1.00 O +ATOM 853 C5' G A 27 -5.628 -2.921 -1.007 1.00 1.00 C +ATOM 854 C4' G A 27 -6.938 -2.698 -0.258 1.00 1.00 C +ATOM 855 O4' G A 27 -7.475 -1.426 -0.615 1.00 1.00 O +ATOM 856 C3' G A 27 -8.035 -3.705 -0.556 1.00 1.00 C +ATOM 857 O3' G A 27 -7.926 -4.809 0.355 1.00 1.00 O +ATOM 858 C2' G A 27 -9.307 -2.926 -0.262 1.00 1.00 C +ATOM 859 O2' G A 27 -9.777 -3.185 1.066 1.00 1.00 O +ATOM 860 C1' G A 27 -8.893 -1.465 -0.429 1.00 1.00 C +ATOM 861 N9 G A 27 -9.556 -0.783 -1.557 1.00 1.00 N +ATOM 862 C8 G A 27 -9.079 -0.490 -2.809 1.00 1.00 C +ATOM 863 N7 G A 27 -9.922 0.168 -3.555 1.00 1.00 N +ATOM 864 C5 G A 27 -11.040 0.323 -2.740 1.00 1.00 C +ATOM 865 C6 G A 27 -12.283 0.962 -3.006 1.00 1.00 C +ATOM 866 O6 G A 27 -12.644 1.532 -4.033 1.00 1.00 O +ATOM 867 N1 G A 27 -13.137 0.889 -1.914 1.00 1.00 N +ATOM 868 C2 G A 27 -12.836 0.280 -0.714 1.00 1.00 C +ATOM 869 N2 G A 27 -13.787 0.307 0.218 1.00 1.00 N +ATOM 870 N3 G A 27 -11.668 -0.318 -0.462 1.00 1.00 N +ATOM 871 C4 G A 27 -10.823 -0.258 -1.516 1.00 1.00 C +ATOM 872 H5' G A 27 -4.862 -2.273 -0.583 1.00 1.00 H +ATOM 873 H5'' G A 27 -5.322 -3.961 -0.885 1.00 1.00 H +ATOM 874 H4' G A 27 -6.738 -2.695 0.811 1.00 1.00 H +ATOM 875 H3' G A 27 -8.001 -4.033 -1.597 1.00 1.00 H +ATOM 876 H2' G A 27 -10.075 -3.179 -0.998 1.00 1.00 H +ATOM 877 HO2' G A 27 -9.446 -4.047 1.322 1.00 1.00 H +ATOM 878 H1' G A 27 -9.133 -0.924 0.486 1.00 1.00 H +ATOM 879 H8 G A 27 -8.087 -0.786 -3.153 1.00 1.00 H +ATOM 880 H1 G A 27 -14.041 1.324 -2.026 1.00 1.00 H +ATOM 881 H21 G A 27 -14.669 0.761 0.025 1.00 1.00 H +ATOM 882 H22 G A 27 -13.625 -0.122 1.117 1.00 1.00 H +ATOM 883 P G A 28 -8.693 -6.199 0.074 1.00 1.00 P +ATOM 884 OP1 G A 28 -7.971 -7.274 0.789 1.00 1.00 O +ATOM 885 OP2 G A 28 -8.926 -6.312 -1.383 1.00 1.00 O +ATOM 886 O5' G A 28 -10.120 -5.985 0.800 1.00 1.00 O +ATOM 887 C5' G A 28 -10.255 -6.157 2.219 1.00 1.00 C +ATOM 888 C4' G A 28 -11.709 -6.401 2.622 1.00 1.00 C +ATOM 889 O4' G A 28 -12.401 -5.154 2.747 1.00 1.00 O +ATOM 890 C3' G A 28 -12.490 -7.255 1.630 1.00 1.00 C +ATOM 891 O3' G A 28 -12.511 -8.615 2.079 1.00 1.00 O +ATOM 892 C2' G A 28 -13.890 -6.666 1.672 1.00 1.00 C +ATOM 893 O2' G A 28 -14.695 -7.297 2.674 1.00 1.00 O +ATOM 894 C1' G A 28 -13.627 -5.208 2.004 1.00 1.00 C +ATOM 895 N9 G A 28 -13.451 -4.355 0.817 1.00 1.00 N +ATOM 896 C8 G A 28 -12.278 -3.921 0.258 1.00 1.00 C +ATOM 897 N7 G A 28 -12.438 -3.184 -0.805 1.00 1.00 N +ATOM 898 C5 G A 28 -13.819 -3.121 -0.965 1.00 1.00 C +ATOM 899 C6 G A 28 -14.590 -2.457 -1.957 1.00 1.00 C +ATOM 900 O6 G A 28 -14.196 -1.783 -2.907 1.00 1.00 O +ATOM 901 N1 G A 28 -15.950 -2.646 -1.755 1.00 1.00 N +ATOM 902 C2 G A 28 -16.503 -3.382 -0.729 1.00 1.00 C +ATOM 903 N2 G A 28 -17.833 -3.448 -0.704 1.00 1.00 N +ATOM 904 N3 G A 28 -15.780 -4.008 0.206 1.00 1.00 N +ATOM 905 C4 G A 28 -14.449 -3.835 0.025 1.00 1.00 C +ATOM 906 H5' G A 28 -9.892 -5.259 2.721 1.00 1.00 H +ATOM 907 H5'' G A 28 -9.651 -7.008 2.533 1.00 1.00 H +ATOM 908 H4' G A 28 -11.723 -6.894 3.593 1.00 1.00 H +ATOM 909 H3' G A 28 -12.062 -7.174 0.629 1.00 1.00 H +ATOM 910 H2' G A 28 -14.356 -6.744 0.691 1.00 1.00 H +ATOM 911 HO2' G A 28 -14.130 -7.465 3.430 1.00 1.00 H +ATOM 912 H1' G A 28 -14.443 -4.817 2.611 1.00 1.00 H +ATOM 913 H8 G A 28 -11.298 -4.166 0.668 1.00 1.00 H +ATOM 914 H1 G A 28 -16.564 -2.202 -2.423 1.00 1.00 H +ATOM 915 H21 G A 28 -18.379 -2.973 -1.414 1.00 1.00 H +ATOM 916 H22 G A 28 -18.299 -3.973 0.022 1.00 1.00 H +ATOM 917 P U A 29 -12.519 -9.824 1.014 1.00 1.00 P +ATOM 918 OP1 U A 29 -12.314 -11.091 1.752 1.00 1.00 O +ATOM 919 OP2 U A 29 -11.613 -9.466 -0.099 1.00 1.00 O +ATOM 920 O5' U A 29 -14.032 -9.807 0.461 1.00 1.00 O +ATOM 921 C5' U A 29 -15.124 -10.151 1.319 1.00 1.00 C +ATOM 922 C4' U A 29 -16.464 -10.036 0.595 1.00 1.00 C +ATOM 923 O4' U A 29 -16.739 -8.672 0.293 1.00 1.00 O +ATOM 924 C3' U A 29 -16.530 -10.789 -0.724 1.00 1.00 C +ATOM 925 O3' U A 29 -16.981 -12.131 -0.498 1.00 1.00 O +ATOM 926 C2' U A 29 -17.567 -10.007 -1.512 1.00 1.00 C +ATOM 927 O2' U A 29 -18.887 -10.518 -1.294 1.00 1.00 O +ATOM 928 C1' U A 29 -17.419 -8.589 -0.969 1.00 1.00 C +ATOM 929 N1 U A 29 -16.624 -7.700 -1.842 1.00 1.00 N +ATOM 930 C2 U A 29 -17.302 -6.952 -2.786 1.00 1.00 C +ATOM 931 O2 U A 29 -18.523 -7.019 -2.921 1.00 1.00 O +ATOM 932 N3 U A 29 -16.527 -6.120 -3.573 1.00 1.00 N +ATOM 933 C4 U A 29 -15.151 -5.974 -3.500 1.00 1.00 C +ATOM 934 O4 U A 29 -14.561 -5.202 -4.254 1.00 1.00 O +ATOM 935 C5 U A 29 -14.527 -6.794 -2.486 1.00 1.00 C +ATOM 936 C6 U A 29 -15.266 -7.616 -1.702 1.00 1.00 C +ATOM 937 H5' U A 29 -15.126 -9.481 2.177 1.00 1.00 H +ATOM 938 H5'' U A 29 -14.995 -11.176 1.668 1.00 1.00 H +ATOM 939 H4' U A 29 -17.248 -10.406 1.250 1.00 1.00 H +ATOM 940 H3' U A 29 -15.563 -10.773 -1.230 1.00 1.00 H +ATOM 941 H2' U A 29 -17.315 -10.022 -2.571 1.00 1.00 H +ATOM 942 HO2' U A 29 -19.198 -10.869 -2.130 1.00 1.00 H +ATOM 943 H1' U A 29 -18.406 -8.155 -0.817 1.00 1.00 H +ATOM 944 H3 U A 29 -17.008 -5.566 -4.268 1.00 1.00 H +ATOM 945 H5 U A 29 -13.446 -6.751 -2.350 1.00 1.00 H +ATOM 946 H6 U A 29 -14.768 -8.224 -0.945 1.00 1.00 H +ATOM 947 P U A 30 -16.575 -13.313 -1.515 1.00 1.00 P +ATOM 948 OP1 U A 30 -16.994 -14.600 -0.916 1.00 1.00 O +ATOM 949 OP2 U A 30 -15.164 -13.114 -1.917 1.00 1.00 O +ATOM 950 O5' U A 30 -17.510 -13.028 -2.797 1.00 1.00 O +ATOM 951 C5' U A 30 -18.921 -13.266 -2.736 1.00 1.00 C +ATOM 952 C4' U A 30 -19.618 -12.866 -4.036 1.00 1.00 C +ATOM 953 O4' U A 30 -19.518 -11.459 -4.230 1.00 1.00 O +ATOM 954 C3' U A 30 -19.043 -13.509 -5.286 1.00 1.00 C +ATOM 955 O3' U A 30 -19.672 -14.775 -5.522 1.00 1.00 O +ATOM 956 C2' U A 30 -19.431 -12.517 -6.370 1.00 1.00 C +ATOM 957 O2' U A 30 -20.741 -12.788 -6.881 1.00 1.00 O +ATOM 958 C1' U A 30 -19.385 -11.180 -5.634 1.00 1.00 C +ATOM 959 N1 U A 30 -18.123 -10.436 -5.821 1.00 1.00 N +ATOM 960 C2 U A 30 -18.094 -9.458 -6.797 1.00 1.00 C +ATOM 961 O2 U A 30 -19.067 -9.213 -7.507 1.00 1.00 O +ATOM 962 N3 U A 30 -16.903 -8.768 -6.929 1.00 1.00 N +ATOM 963 C4 U A 30 -15.755 -8.969 -6.180 1.00 1.00 C +ATOM 964 O4 U A 30 -14.749 -8.293 -6.384 1.00 1.00 O +ATOM 965 C5 U A 30 -15.876 -10.009 -5.184 1.00 1.00 C +ATOM 966 C6 U A 30 -17.033 -10.700 -5.036 1.00 1.00 C +ATOM 967 H5' U A 30 -19.345 -12.688 -1.915 1.00 1.00 H +ATOM 968 H5'' U A 30 -19.096 -14.326 -2.552 1.00 1.00 H +ATOM 969 H4' U A 30 -20.672 -13.125 -3.962 1.00 1.00 H +ATOM 970 H3' U A 30 -17.957 -13.606 -5.211 1.00 1.00 H +ATOM 971 H2' U A 30 -18.691 -12.529 -7.169 1.00 1.00 H +ATOM 972 HO2' U A 30 -21.370 -12.446 -6.240 1.00 1.00 H +ATOM 973 H1' U A 30 -20.218 -10.555 -5.955 1.00 1.00 H +ATOM 974 H3 U A 30 -16.866 -8.049 -7.638 1.00 1.00 H +ATOM 975 H5 U A 30 -15.025 -10.243 -4.545 1.00 1.00 H +ATOM 976 H6 U A 30 -17.098 -11.479 -4.277 1.00 1.00 H +ATOM 977 P C A 31 -18.863 -15.971 -6.236 1.00 1.00 P +ATOM 978 OP1 C A 31 -19.768 -17.136 -6.346 1.00 1.00 O +ATOM 979 OP2 C A 31 -17.556 -16.115 -5.557 1.00 1.00 O +ATOM 980 O5' C A 31 -18.601 -15.400 -7.721 1.00 1.00 O +ATOM 981 C5' C A 31 -19.639 -15.431 -8.706 1.00 1.00 C +ATOM 982 C4' C A 31 -19.346 -14.486 -9.868 1.00 1.00 C +ATOM 983 O4' C A 31 -19.041 -13.187 -9.375 1.00 1.00 O +ATOM 984 C3' C A 31 -18.162 -14.888 -10.730 1.00 1.00 C +ATOM 985 O3' C A 31 -18.587 -15.808 -11.743 1.00 1.00 O +ATOM 986 C2' C A 31 -17.754 -13.567 -11.359 1.00 1.00 C +ATOM 987 O2' C A 31 -18.460 -13.331 -12.584 1.00 1.00 O +ATOM 988 C1' C A 31 -18.141 -12.541 -10.291 1.00 1.00 C +ATOM 989 N1 C A 31 -16.992 -12.034 -9.512 1.00 1.00 N +ATOM 990 C2 C A 31 -16.438 -10.828 -9.910 1.00 1.00 C +ATOM 991 O2 C A 31 -16.902 -10.228 -10.878 1.00 1.00 O +ATOM 992 N3 C A 31 -15.381 -10.339 -9.207 1.00 1.00 N +ATOM 993 C4 C A 31 -14.887 -11.005 -8.155 1.00 1.00 C +ATOM 994 N4 C A 31 -13.850 -10.497 -7.487 1.00 1.00 N +ATOM 995 C5 C A 31 -15.456 -12.251 -7.739 1.00 1.00 C +ATOM 996 C6 C A 31 -16.502 -12.726 -8.442 1.00 1.00 C +ATOM 997 H5' C A 31 -20.580 -15.140 -8.241 1.00 1.00 H +ATOM 998 H5'' C A 31 -19.731 -16.446 -9.092 1.00 1.00 H +ATOM 999 H4' C A 31 -20.232 -14.413 -10.494 1.00 1.00 H +ATOM 1000 H3' C A 31 -17.355 -15.301 -10.122 1.00 1.00 H +ATOM 1001 H2' C A 31 -16.676 -13.547 -11.522 1.00 1.00 H +ATOM 1002 HO2' C A 31 -18.780 -12.426 -12.558 1.00 1.00 H +ATOM 1003 H1' C A 31 -18.654 -11.701 -10.762 1.00 1.00 H +ATOM 1004 H41 C A 31 -13.446 -9.612 -7.785 1.00 1.00 H +ATOM 1005 H42 C A 31 -13.466 -10.989 -6.692 1.00 1.00 H +ATOM 1006 H5 C A 31 -15.057 -12.794 -6.883 1.00 1.00 H +ATOM 1007 H6 C A 31 -16.962 -13.671 -8.153 1.00 1.00 H +ATOM 1008 P U A 32 -17.762 -17.167 -12.010 1.00 1.00 P +ATOM 1009 OP1 U A 32 -18.640 -18.102 -12.751 1.00 1.00 O +ATOM 1010 OP2 U A 32 -17.144 -17.592 -10.734 1.00 1.00 O +ATOM 1011 O5' U A 32 -16.586 -16.680 -12.997 1.00 1.00 O +ATOM 1012 C5' U A 32 -16.877 -15.816 -14.096 1.00 1.00 C +ATOM 1013 C4' U A 32 -15.782 -14.767 -14.302 1.00 1.00 C +ATOM 1014 O4' U A 32 -15.708 -13.886 -13.184 1.00 1.00 O +ATOM 1015 C3' U A 32 -14.378 -15.325 -14.471 1.00 1.00 C +ATOM 1016 O3' U A 32 -14.149 -15.646 -15.850 1.00 1.00 O +ATOM 1017 C2' U A 32 -13.496 -14.156 -14.063 1.00 1.00 C +ATOM 1018 O2' U A 32 -13.041 -13.417 -15.199 1.00 1.00 O +ATOM 1019 C1' U A 32 -14.392 -13.308 -13.167 1.00 1.00 C +ATOM 1020 N1 U A 32 -13.918 -13.210 -11.769 1.00 1.00 N +ATOM 1021 C2 U A 32 -13.112 -12.134 -11.453 1.00 1.00 C +ATOM 1022 O2 U A 32 -12.778 -11.299 -12.291 1.00 1.00 O +ATOM 1023 N3 U A 32 -12.699 -12.049 -10.136 1.00 1.00 N +ATOM 1024 C4 U A 32 -13.018 -12.938 -9.122 1.00 1.00 C +ATOM 1025 O4 U A 32 -12.595 -12.763 -7.981 1.00 1.00 O +ATOM 1026 C5 U A 32 -13.863 -14.032 -9.542 1.00 1.00 C +ATOM 1027 C6 U A 32 -14.280 -14.135 -10.826 1.00 1.00 C +ATOM 1028 H5' U A 32 -17.821 -15.307 -13.903 1.00 1.00 H +ATOM 1029 H5'' U A 32 -16.974 -16.410 -15.005 1.00 1.00 H +ATOM 1030 H4' U A 32 -16.031 -14.178 -15.184 1.00 1.00 H +ATOM 1031 H3' U A 32 -14.216 -16.188 -13.825 1.00 1.00 H +ATOM 1032 H2' U A 32 -12.657 -14.522 -13.479 1.00 1.00 H +ATOM 1033 HO2' U A 32 -13.079 -12.487 -14.969 1.00 1.00 H +ATOM 1034 H1' U A 32 -14.451 -12.303 -13.590 1.00 1.00 H +ATOM 1035 H3 U A 32 -12.110 -11.267 -9.890 1.00 1.00 H +ATOM 1036 H5 U A 32 -14.167 -14.785 -8.815 1.00 1.00 H +ATOM 1037 H6 U A 32 -14.917 -14.971 -11.116 1.00 1.00 H +ATOM 1038 P U A 33 -12.973 -16.660 -16.281 1.00 1.00 P +ATOM 1039 OP1 U A 33 -13.123 -16.949 -17.725 1.00 1.00 O +ATOM 1040 OP2 U A 33 -12.941 -17.774 -15.307 1.00 1.00 O +ATOM 1041 O5' U A 33 -11.634 -15.780 -16.085 1.00 1.00 O +ATOM 1042 C5' U A 33 -11.240 -14.824 -17.077 1.00 1.00 C +ATOM 1043 C4' U A 33 -9.890 -14.179 -16.754 1.00 1.00 C +ATOM 1044 O4' U A 33 -9.994 -13.412 -15.559 1.00 1.00 O +ATOM 1045 C3' U A 33 -8.755 -15.166 -16.527 1.00 1.00 C +ATOM 1046 O3' U A 33 -8.060 -15.404 -17.752 1.00 1.00 O +ATOM 1047 C2' U A 33 -7.828 -14.443 -15.560 1.00 1.00 C +ATOM 1048 O2' U A 33 -6.757 -13.795 -16.253 1.00 1.00 O +ATOM 1049 C1' U A 33 -8.734 -13.429 -14.868 1.00 1.00 C +ATOM 1050 N1 U A 33 -9.010 -13.752 -13.454 1.00 1.00 N +ATOM 1051 C2 U A 33 -8.232 -13.145 -12.486 1.00 1.00 C +ATOM 1052 O2 U A 33 -7.320 -12.371 -12.771 1.00 1.00 O +ATOM 1053 N3 U A 33 -8.540 -13.458 -11.174 1.00 1.00 N +ATOM 1054 C4 U A 33 -9.543 -14.314 -10.753 1.00 1.00 C +ATOM 1055 O4 U A 33 -9.729 -14.520 -9.555 1.00 1.00 O +ATOM 1056 C5 U A 33 -10.305 -14.903 -11.831 1.00 1.00 C +ATOM 1057 C6 U A 33 -10.023 -14.611 -13.123 1.00 1.00 C +ATOM 1058 H5' U A 33 -11.998 -14.044 -17.139 1.00 1.00 H +ATOM 1059 H5'' U A 33 -11.168 -15.325 -18.043 1.00 1.00 H +ATOM 1060 H4' U A 33 -9.617 -13.508 -17.566 1.00 1.00 H +ATOM 1061 H3' U A 33 -9.127 -16.095 -16.091 1.00 1.00 H +ATOM 1062 H2' U A 33 -7.439 -15.151 -14.827 1.00 1.00 H +ATOM 1063 HO2' U A 33 -6.535 -14.342 -17.011 1.00 1.00 H +ATOM 1064 H1' U A 33 -8.279 -12.440 -14.930 1.00 1.00 H +ATOM 1065 H3 U A 33 -7.980 -13.021 -10.456 1.00 1.00 H +ATOM 1066 H5 U A 33 -11.118 -15.592 -11.600 1.00 1.00 H +ATOM 1067 H6 U A 33 -10.614 -15.071 -13.916 1.00 1.00 H +ATOM 1068 P C A 34 -6.929 -16.546 -17.822 1.00 1.00 P +ATOM 1069 OP1 C A 34 -6.447 -16.641 -19.218 1.00 1.00 O +ATOM 1070 OP2 C A 34 -7.443 -17.751 -17.134 1.00 1.00 O +ATOM 1071 O5' C A 34 -5.749 -15.915 -16.922 1.00 1.00 O +ATOM 1072 C5' C A 34 -5.190 -16.651 -15.829 1.00 1.00 C +ATOM 1073 C4' C A 34 -4.239 -15.790 -14.995 1.00 1.00 C +ATOM 1074 O4' C A 34 -4.984 -14.934 -14.129 1.00 1.00 O +ATOM 1075 C3' C A 34 -3.296 -16.591 -14.112 1.00 1.00 C +ATOM 1076 O3' C A 34 -2.065 -16.811 -14.806 1.00 1.00 O +ATOM 1077 C2' C A 34 -3.057 -15.686 -12.909 1.00 1.00 C +ATOM 1078 O2' C A 34 -1.838 -14.949 -13.050 1.00 1.00 O +ATOM 1079 C1' C A 34 -4.270 -14.756 -12.895 1.00 1.00 C +ATOM 1080 N1 C A 34 -5.217 -15.025 -11.796 1.00 1.00 N +ATOM 1081 C2 C A 34 -4.931 -14.495 -10.549 1.00 1.00 C +ATOM 1082 O2 C A 34 -3.913 -13.826 -10.383 1.00 1.00 O +ATOM 1083 N3 C A 34 -5.804 -14.732 -9.531 1.00 1.00 N +ATOM 1084 C4 C A 34 -6.910 -15.462 -9.729 1.00 1.00 C +ATOM 1085 N4 C A 34 -7.742 -15.677 -8.711 1.00 1.00 N +ATOM 1086 C5 C A 34 -7.208 -16.012 -11.016 1.00 1.00 C +ATOM 1087 C6 C A 34 -6.340 -15.770 -12.016 1.00 1.00 C +ATOM 1088 H5' C A 34 -4.642 -17.507 -16.220 1.00 1.00 H +ATOM 1089 H5'' C A 34 -5.997 -17.007 -15.190 1.00 1.00 H +ATOM 1090 H4' C A 34 -3.649 -15.170 -15.667 1.00 1.00 H +ATOM 1091 H3' C A 34 -3.754 -17.533 -13.806 1.00 1.00 H +ATOM 1092 H2' C A 34 -3.039 -16.285 -11.995 1.00 1.00 H +ATOM 1093 HO2' C A 34 -1.119 -15.584 -13.048 1.00 1.00 H +ATOM 1094 H1' C A 34 -3.928 -13.725 -12.824 1.00 1.00 H +ATOM 1095 H41 C A 34 -7.540 -15.292 -7.806 1.00 1.00 H +ATOM 1096 H42 C A 34 -8.579 -16.225 -8.851 1.00 1.00 H +ATOM 1097 H5 C A 34 -8.107 -16.605 -11.181 1.00 1.00 H +ATOM 1098 H6 C A 34 -6.535 -16.173 -13.010 1.00 1.00 H +ATOM 1099 P C A 35 -1.077 -18.003 -14.367 1.00 1.00 P +ATOM 1100 OP1 C A 35 0.017 -18.089 -15.360 1.00 1.00 O +ATOM 1101 OP2 C A 35 -1.896 -19.198 -14.063 1.00 1.00 O +ATOM 1102 O5' C A 35 -0.459 -17.451 -12.987 1.00 1.00 O +ATOM 1103 C5' C A 35 -0.117 -18.354 -11.934 1.00 1.00 C +ATOM 1104 C4' C A 35 0.551 -17.630 -10.769 1.00 1.00 C +ATOM 1105 O4' C A 35 -0.322 -16.623 -10.259 1.00 1.00 O +ATOM 1106 C3' C A 35 0.915 -18.541 -9.608 1.00 1.00 C +ATOM 1107 O3' C A 35 2.277 -18.957 -9.743 1.00 1.00 O +ATOM 1108 C2' C A 35 0.756 -17.657 -8.381 1.00 1.00 C +ATOM 1109 O2' C A 35 2.002 -17.059 -8.005 1.00 1.00 O +ATOM 1110 C1' C A 35 -0.255 -16.602 -8.826 1.00 1.00 C +ATOM 1111 N1 C A 35 -1.622 -16.826 -8.320 1.00 1.00 N +ATOM 1112 C2 C A 35 -1.867 -16.527 -6.990 1.00 1.00 C +ATOM 1113 O2 C A 35 -0.960 -16.101 -6.278 1.00 1.00 O +ATOM 1114 N3 C A 35 -3.125 -16.719 -6.506 1.00 1.00 N +ATOM 1115 C4 C A 35 -4.102 -17.185 -7.296 1.00 1.00 C +ATOM 1116 N4 C A 35 -5.322 -17.362 -6.791 1.00 1.00 N +ATOM 1117 C5 C A 35 -3.852 -17.495 -8.670 1.00 1.00 C +ATOM 1118 C6 C A 35 -2.605 -17.303 -9.139 1.00 1.00 C +ATOM 1119 H5' C A 35 0.568 -19.109 -12.321 1.00 1.00 H +ATOM 1120 H5'' C A 35 -1.022 -18.844 -11.577 1.00 1.00 H +ATOM 1121 H4' C A 35 1.456 -17.146 -11.131 1.00 1.00 H +ATOM 1122 H3' C A 35 0.240 -19.399 -9.560 1.00 1.00 H +ATOM 1123 H2' C A 35 0.344 -18.241 -7.554 1.00 1.00 H +ATOM 1124 HO2' C A 35 2.529 -16.972 -8.802 1.00 1.00 H +ATOM 1125 H1' C A 35 0.087 -15.620 -8.499 1.00 1.00 H +ATOM 1126 H41 C A 35 -5.505 -17.145 -5.823 1.00 1.00 H +ATOM 1127 H42 C A 35 -6.066 -17.713 -7.378 1.00 1.00 H +ATOM 1128 H5 C A 35 -4.645 -17.877 -9.315 1.00 1.00 H +ATOM 1129 H6 C A 35 -2.378 -17.528 -10.180 1.00 1.00 H +ATOM 1130 P U A 36 2.727 -20.439 -9.306 1.00 1.00 P +ATOM 1131 OP1 U A 36 3.895 -20.829 -10.128 1.00 1.00 O +ATOM 1132 OP2 U A 36 1.523 -21.300 -9.277 1.00 1.00 O +ATOM 1133 O5' U A 36 3.227 -20.221 -7.793 1.00 1.00 O +ATOM 1134 C5' U A 36 3.020 -21.235 -6.806 1.00 1.00 C +ATOM 1135 C4' U A 36 3.171 -20.678 -5.396 1.00 1.00 C +ATOM 1136 O4' U A 36 2.117 -19.752 -5.128 1.00 1.00 O +ATOM 1137 C3' U A 36 3.129 -21.739 -4.306 1.00 1.00 C +ATOM 1138 O3' U A 36 4.464 -22.114 -3.950 1.00 1.00 O +ATOM 1139 C2' U A 36 2.465 -21.041 -3.132 1.00 1.00 C +ATOM 1140 O2' U A 36 3.439 -20.520 -2.220 1.00 1.00 O +ATOM 1141 C1' U A 36 1.660 -19.920 -3.781 1.00 1.00 C +ATOM 1142 N1 U A 36 0.211 -20.183 -3.830 1.00 1.00 N +ATOM 1143 C2 U A 36 -0.446 -20.300 -2.620 1.00 1.00 C +ATOM 1144 O2 U A 36 0.144 -20.207 -1.545 1.00 1.00 O +ATOM 1145 N3 U A 36 -1.807 -20.528 -2.687 1.00 1.00 N +ATOM 1146 C4 U A 36 -2.559 -20.648 -3.844 1.00 1.00 C +ATOM 1147 O4 U A 36 -3.770 -20.851 -3.786 1.00 1.00 O +ATOM 1148 C5 U A 36 -1.791 -20.512 -5.061 1.00 1.00 C +ATOM 1149 C6 U A 36 -0.455 -20.289 -5.020 1.00 1.00 C +ATOM 1150 H5' U A 36 3.747 -22.032 -6.955 1.00 1.00 H +ATOM 1151 H5'' U A 36 2.015 -21.642 -6.921 1.00 1.00 H +ATOM 1152 H4' U A 36 4.119 -20.145 -5.329 1.00 1.00 H +ATOM 1153 H3' U A 36 2.546 -22.604 -4.626 1.00 1.00 H +ATOM 1154 H2' U A 36 1.791 -21.733 -2.622 1.00 1.00 H +ATOM 1155 HO2' U A 36 3.127 -19.659 -1.931 1.00 1.00 H +ATOM 1156 H1' U A 36 1.830 -18.996 -3.230 1.00 1.00 H +ATOM 1157 H3 U A 36 -2.301 -20.616 -1.811 1.00 1.00 H +ATOM 1158 H5 U A 36 -2.293 -20.591 -6.026 1.00 1.00 H +ATOM 1159 H6 U A 36 0.099 -20.192 -5.953 1.00 1.00 H +ATOM 1160 P A A 37 4.777 -23.583 -3.368 1.00 1.00 P +ATOM 1161 OP1 A A 37 6.239 -23.702 -3.173 1.00 1.00 O +ATOM 1162 OP2 A A 37 4.060 -24.572 -4.204 1.00 1.00 O +ATOM 1163 O5' A A 37 4.076 -23.546 -1.918 1.00 1.00 O +ATOM 1164 C5' A A 37 4.456 -22.566 -0.948 1.00 1.00 C +ATOM 1165 C4' A A 37 3.722 -22.774 0.376 1.00 1.00 C +ATOM 1166 O4' A A 37 2.319 -22.579 0.177 1.00 1.00 O +ATOM 1167 C3' A A 37 3.912 -24.162 0.974 1.00 1.00 C +ATOM 1168 O3' A A 37 4.011 -24.061 2.398 1.00 1.00 O +ATOM 1169 C2' A A 37 2.644 -24.913 0.599 1.00 1.00 C +ATOM 1170 O2' A A 37 2.246 -25.812 1.639 1.00 1.00 O +ATOM 1171 C1' A A 37 1.613 -23.807 0.400 1.00 1.00 C +ATOM 1172 N9 A A 37 0.723 -24.024 -0.758 1.00 1.00 N +ATOM 1173 C8 A A 37 1.056 -24.374 -2.040 1.00 1.00 C +ATOM 1174 N7 A A 37 0.031 -24.489 -2.839 1.00 1.00 N +ATOM 1175 C5 A A 37 -1.058 -24.192 -2.027 1.00 1.00 C +ATOM 1176 C6 A A 37 -2.440 -24.138 -2.276 1.00 1.00 C +ATOM 1177 N6 A A 37 -2.978 -24.392 -3.470 1.00 1.00 N +ATOM 1178 N1 A A 37 -3.238 -23.811 -1.247 1.00 1.00 N +ATOM 1179 C2 A A 37 -2.697 -23.560 -0.060 1.00 1.00 C +ATOM 1180 N3 A A 37 -1.422 -23.579 0.297 1.00 1.00 N +ATOM 1181 C4 A A 37 -0.647 -23.909 -0.756 1.00 1.00 C +ATOM 1182 H5' A A 37 4.225 -21.574 -1.331 1.00 1.00 H +ATOM 1183 H5'' A A 37 5.530 -22.639 -0.773 1.00 1.00 H +ATOM 1184 H4' A A 37 4.074 -22.032 1.091 1.00 1.00 H +ATOM 1185 H3' A A 37 4.792 -24.650 0.550 1.00 1.00 H +ATOM 1186 H2' A A 37 2.795 -25.452 -0.339 1.00 1.00 H +ATOM 1187 HO2' A A 37 2.711 -26.639 1.494 1.00 1.00 H +ATOM 1188 H1' A A 37 1.008 -23.715 1.300 1.00 1.00 H +ATOM 1189 H8 A A 37 2.084 -24.543 -2.363 1.00 1.00 H +ATOM 1190 H61 A A 37 -3.979 -24.338 -3.594 1.00 1.00 H +ATOM 1191 H62 A A 37 -2.385 -24.638 -4.249 1.00 1.00 H +ATOM 1192 H2 A A 37 -3.402 -23.302 0.730 1.00 1.00 H +ATOM 1193 P A A 38 5.350 -23.490 3.086 1.00 1.00 P +ATOM 1194 OP1 A A 38 5.021 -22.206 3.744 1.00 1.00 O +ATOM 1195 OP2 A A 38 6.443 -23.550 2.090 1.00 1.00 O +ATOM 1196 O5' A A 38 5.655 -24.578 4.234 1.00 1.00 O +ATOM 1197 C5' A A 38 4.597 -25.105 5.038 1.00 1.00 C +ATOM 1198 C4' A A 38 4.162 -24.113 6.113 1.00 1.00 C +ATOM 1199 O4' A A 38 3.573 -22.968 5.497 1.00 1.00 O +ATOM 1200 C3' A A 38 3.150 -24.681 7.099 1.00 1.00 C +ATOM 1201 O3' A A 38 3.823 -25.078 8.300 1.00 1.00 O +ATOM 1202 C2' A A 38 2.218 -23.515 7.389 1.00 1.00 C +ATOM 1203 O2' A A 38 2.635 -22.790 8.551 1.00 1.00 O +ATOM 1204 C1' A A 38 2.326 -22.661 6.131 1.00 1.00 C +ATOM 1205 N9 A A 38 1.260 -22.912 5.145 1.00 1.00 N +ATOM 1206 C8 A A 38 1.360 -23.466 3.895 1.00 1.00 C +ATOM 1207 N7 A A 38 0.222 -23.551 3.263 1.00 1.00 N +ATOM 1208 C5 A A 38 -0.697 -23.013 4.159 1.00 1.00 C +ATOM 1209 C6 A A 38 -2.086 -22.813 4.090 1.00 1.00 C +ATOM 1210 N6 A A 38 -2.821 -23.150 3.029 1.00 1.00 N +ATOM 1211 N1 A A 38 -2.682 -22.255 5.156 1.00 1.00 N +ATOM 1212 C2 A A 38 -1.946 -21.921 6.210 1.00 1.00 C +ATOM 1213 N3 A A 38 -0.642 -22.058 6.395 1.00 1.00 N +ATOM 1214 C4 A A 38 -0.072 -22.620 5.308 1.00 1.00 C +ATOM 1215 H5' A A 38 4.938 -26.022 5.518 1.00 1.00 H +ATOM 1216 H5'' A A 38 3.744 -25.333 4.399 1.00 1.00 H +ATOM 1217 H4' A A 38 5.043 -23.789 6.664 1.00 1.00 H +ATOM 1218 H3' A A 38 2.602 -25.515 6.657 1.00 1.00 H +ATOM 1219 H2' A A 38 1.194 -23.878 7.505 1.00 1.00 H +ATOM 1220 HO2' A A 38 1.935 -22.871 9.203 1.00 1.00 H +ATOM 1221 H1' A A 38 2.312 -21.608 6.410 1.00 1.00 H +ATOM 1222 H8 A A 38 2.304 -23.806 3.469 1.00 1.00 H +ATOM 1223 H61 A A 38 -3.817 -22.985 3.031 1.00 1.00 H +ATOM 1224 H62 A A 38 -2.379 -23.572 2.223 1.00 1.00 H +ATOM 1225 H2 A A 38 -2.493 -21.473 7.039 1.00 1.00 H +ATOM 1226 P G A 39 3.253 -26.287 9.198 1.00 1.00 P +ATOM 1227 OP1 G A 39 4.364 -26.808 10.026 1.00 1.00 O +ATOM 1228 OP2 G A 39 2.496 -27.203 8.317 1.00 1.00 O +ATOM 1229 O5' G A 39 2.207 -25.541 10.169 1.00 1.00 O +ATOM 1230 C5' G A 39 1.021 -26.209 10.609 1.00 1.00 C +ATOM 1231 C4' G A 39 -0.162 -25.249 10.694 1.00 1.00 C +ATOM 1232 O4' G A 39 -0.179 -24.414 9.531 1.00 1.00 O +ATOM 1233 C3' G A 39 -1.516 -25.948 10.784 1.00 1.00 C +ATOM 1234 O3' G A 39 -1.980 -25.928 12.140 1.00 1.00 O +ATOM 1235 C2' G A 39 -2.430 -25.097 9.917 1.00 1.00 C +ATOM 1236 O2' G A 39 -3.113 -24.107 10.693 1.00 1.00 O +ATOM 1237 C1' G A 39 -1.473 -24.458 8.921 1.00 1.00 C +ATOM 1238 N9 G A 39 -1.340 -25.201 7.654 1.00 1.00 N +ATOM 1239 C8 G A 39 -0.296 -25.976 7.219 1.00 1.00 C +ATOM 1240 N7 G A 39 -0.488 -26.511 6.046 1.00 1.00 N +ATOM 1241 C5 G A 39 -1.749 -26.058 5.673 1.00 1.00 C +ATOM 1242 C6 G A 39 -2.496 -26.310 4.489 1.00 1.00 C +ATOM 1243 O6 G A 39 -2.180 -26.998 3.521 1.00 1.00 O +ATOM 1244 N1 G A 39 -3.722 -25.661 4.512 1.00 1.00 N +ATOM 1245 C2 G A 39 -4.178 -24.868 5.543 1.00 1.00 C +ATOM 1246 N2 G A 39 -5.385 -24.327 5.381 1.00 1.00 N +ATOM 1247 N3 G A 39 -3.479 -24.629 6.657 1.00 1.00 N +ATOM 1248 C4 G A 39 -2.280 -25.254 6.652 1.00 1.00 C +ATOM 1249 H5' G A 39 1.200 -26.641 11.592 1.00 1.00 H +ATOM 1250 H5'' G A 39 0.782 -27.008 9.907 1.00 1.00 H +ATOM 1251 H4' G A 39 -0.035 -24.615 11.569 1.00 1.00 H +ATOM 1252 H3' G A 39 -1.453 -26.966 10.403 1.00 1.00 H +ATOM 1253 H2' G A 39 -3.143 -25.734 9.390 1.00 1.00 H +ATOM 1254 HO2' G A 39 -4.053 -24.223 10.542 1.00 1.00 H +ATOM 1255 H1' G A 39 -1.803 -23.443 8.706 1.00 1.00 H +ATOM 1256 H8 G A 39 0.612 -26.131 7.802 1.00 1.00 H +ATOM 1257 H1 G A 39 -4.311 -25.793 3.702 1.00 1.00 H +ATOM 1258 H21 G A 39 -5.912 -24.509 4.538 1.00 1.00 H +ATOM 1259 H22 G A 39 -5.774 -23.736 6.101 1.00 1.00 H +ATOM 1260 P U A 40 -2.398 -27.297 12.882 1.00 1.00 P +ATOM 1261 OP1 U A 40 -2.653 -26.988 14.306 1.00 1.00 O +ATOM 1262 OP2 U A 40 -1.410 -28.338 12.520 1.00 1.00 O +ATOM 1263 O5' U A 40 -3.805 -27.675 12.191 1.00 1.00 O +ATOM 1264 C5' U A 40 -5.041 -27.240 12.769 1.00 1.00 C +ATOM 1265 C4' U A 40 -6.212 -27.425 11.805 1.00 1.00 C +ATOM 1266 O4' U A 40 -5.914 -26.796 10.558 1.00 1.00 O +ATOM 1267 C3' U A 40 -6.545 -28.877 11.498 1.00 1.00 C +ATOM 1268 O3' U A 40 -7.553 -29.350 12.401 1.00 1.00 O +ATOM 1269 C2' U A 40 -7.102 -28.817 10.085 1.00 1.00 C +ATOM 1270 O2' U A 40 -8.522 -28.642 10.084 1.00 1.00 O +ATOM 1271 C1' U A 40 -6.394 -27.612 9.479 1.00 1.00 C +ATOM 1272 N1 U A 40 -5.232 -27.968 8.641 1.00 1.00 N +ATOM 1273 C2 U A 40 -5.431 -28.088 7.279 1.00 1.00 C +ATOM 1274 O2 U A 40 -6.533 -27.919 6.762 1.00 1.00 O +ATOM 1275 N3 U A 40 -4.314 -28.408 6.528 1.00 1.00 N +ATOM 1276 C4 U A 40 -3.035 -28.616 7.014 1.00 1.00 C +ATOM 1277 O4 U A 40 -2.113 -28.897 6.251 1.00 1.00 O +ATOM 1278 C5 U A 40 -2.920 -28.472 8.449 1.00 1.00 C +ATOM 1279 C6 U A 40 -4.000 -28.158 9.205 1.00 1.00 C +ATOM 1280 H5' U A 40 -4.958 -26.184 13.029 1.00 1.00 H +ATOM 1281 H5'' U A 40 -5.232 -27.816 13.673 1.00 1.00 H +ATOM 1282 H4' U A 40 -7.092 -26.945 12.228 1.00 1.00 H +ATOM 1283 H3' U A 40 -5.649 -29.500 11.537 1.00 1.00 H +ATOM 1284 H2' U A 40 -6.823 -29.715 9.537 1.00 1.00 H +ATOM 1285 HO2' U A 40 -8.825 -28.776 9.183 1.00 1.00 H +ATOM 1286 H1' U A 40 -7.104 -27.038 8.884 1.00 1.00 H +ATOM 1287 H3 U A 40 -4.444 -28.497 5.530 1.00 1.00 H +ATOM 1288 H5 U A 40 -1.952 -28.617 8.927 1.00 1.00 H +ATOM 1289 H6 U A 40 -3.884 -28.055 10.283 1.00 1.00 H +ATOM 1290 P C A 41 -7.514 -30.863 12.957 1.00 1.00 P +ATOM 1291 OP1 C A 41 -8.324 -30.921 14.193 1.00 1.00 O +ATOM 1292 OP2 C A 41 -6.105 -31.314 12.977 1.00 1.00 O +ATOM 1293 O5' C A 41 -8.290 -31.686 11.810 1.00 1.00 O +ATOM 1294 C5' C A 41 -9.709 -31.574 11.661 1.00 1.00 C +ATOM 1295 C4' C A 41 -10.158 -31.991 10.263 1.00 1.00 C +ATOM 1296 O4' C A 41 -9.396 -31.274 9.291 1.00 1.00 O +ATOM 1297 C3' C A 41 -9.982 -33.474 9.957 1.00 1.00 C +ATOM 1298 O3' C A 41 -11.197 -34.179 10.244 1.00 1.00 O +ATOM 1299 C2' C A 41 -9.720 -33.482 8.460 1.00 1.00 C +ATOM 1300 O2' C A 41 -10.942 -33.540 7.716 1.00 1.00 O +ATOM 1301 C1' C A 41 -8.998 -32.162 8.238 1.00 1.00 C +ATOM 1302 N1 C A 41 -7.524 -32.271 8.273 1.00 1.00 N +ATOM 1303 C2 C A 41 -6.867 -32.386 7.058 1.00 1.00 C +ATOM 1304 O2 C A 41 -7.512 -32.412 6.010 1.00 1.00 O +ATOM 1305 N3 C A 41 -5.508 -32.468 7.062 1.00 1.00 N +ATOM 1306 C4 C A 41 -4.821 -32.439 8.213 1.00 1.00 C +ATOM 1307 N4 C A 41 -3.492 -32.524 8.183 1.00 1.00 N +ATOM 1308 C5 C A 41 -5.495 -32.320 9.469 1.00 1.00 C +ATOM 1309 C6 C A 41 -6.840 -32.239 9.454 1.00 1.00 C +ATOM 1310 H5' C A 41 -10.006 -30.539 11.834 1.00 1.00 H +ATOM 1311 H5'' C A 41 -10.198 -32.213 12.397 1.00 1.00 H +ATOM 1312 H4' C A 41 -11.206 -31.728 10.136 1.00 1.00 H +ATOM 1313 H3' C A 41 -9.135 -33.891 10.506 1.00 1.00 H +ATOM 1314 H2' C A 41 -9.067 -34.309 8.195 1.00 1.00 H +ATOM 1315 HO2' C A 41 -10.721 -33.828 6.828 1.00 1.00 H +ATOM 1316 H1' C A 41 -9.303 -31.743 7.282 1.00 1.00 H +ATOM 1317 H41 C A 41 -3.006 -32.610 7.294 1.00 1.00 H +ATOM 1318 H42 C A 41 -2.965 -32.503 9.047 1.00 1.00 H +ATOM 1319 H5 C A 41 -4.939 -32.297 10.408 1.00 1.00 H +ATOM 1320 H6 C A 41 -7.386 -32.148 10.392 1.00 1.00 H +ATOM 1321 P C A 42 -11.175 -35.753 10.595 1.00 1.00 P +ATOM 1322 OP1 C A 42 -12.574 -36.205 10.775 1.00 1.00 O +ATOM 1323 OP2 C A 42 -10.185 -35.975 11.672 1.00 1.00 O +ATOM 1324 O5' C A 42 -10.605 -36.411 9.240 1.00 1.00 O +ATOM 1325 C5' C A 42 -11.319 -36.266 8.012 1.00 1.00 C +ATOM 1326 C4' C A 42 -10.415 -36.498 6.803 1.00 1.00 C +ATOM 1327 O4' C A 42 -9.238 -35.705 6.930 1.00 1.00 O +ATOM 1328 C3' C A 42 -9.936 -37.931 6.626 1.00 1.00 C +ATOM 1329 O3' C A 42 -10.848 -38.652 5.793 1.00 1.00 O +ATOM 1330 C2' C A 42 -8.612 -37.773 5.898 1.00 1.00 C +ATOM 1331 O2' C A 42 -8.769 -37.949 4.486 1.00 1.00 O +ATOM 1332 C1' C A 42 -8.166 -36.358 6.238 1.00 1.00 C +ATOM 1333 N1 C A 42 -6.957 -36.315 7.083 1.00 1.00 N +ATOM 1334 C2 C A 42 -5.739 -36.419 6.431 1.00 1.00 C +ATOM 1335 O2 C A 42 -5.704 -36.564 5.211 1.00 1.00 O +ATOM 1336 N3 C A 42 -4.600 -36.361 7.176 1.00 1.00 N +ATOM 1337 C4 C A 42 -4.656 -36.207 8.506 1.00 1.00 C +ATOM 1338 N4 C A 42 -3.522 -36.153 9.205 1.00 1.00 N +ATOM 1339 C5 C A 42 -5.912 -36.100 9.183 1.00 1.00 C +ATOM 1340 C6 C A 42 -7.033 -36.158 8.437 1.00 1.00 C +ATOM 1341 H5' C A 42 -11.731 -35.258 7.958 1.00 1.00 H +ATOM 1342 H5'' C A 42 -12.138 -36.986 7.987 1.00 1.00 H +ATOM 1343 H4' C A 42 -10.941 -36.187 5.904 1.00 1.00 H +ATOM 1344 H3' C A 42 -9.798 -38.423 7.590 1.00 1.00 H +ATOM 1345 H2' C A 42 -7.889 -38.481 6.296 1.00 1.00 H +ATOM 1346 HO2' C A 42 -8.856 -37.076 4.098 1.00 1.00 H +ATOM 1347 H1' C A 42 -7.969 -35.820 5.311 1.00 1.00 H +ATOM 1348 H41 C A 42 -2.634 -36.228 8.731 1.00 1.00 H +ATOM 1349 H42 C A 42 -3.552 -36.037 10.208 1.00 1.00 H +ATOM 1350 H5 C A 42 -5.960 -35.975 10.265 1.00 1.00 H +ATOM 1351 H6 C A 42 -8.006 -36.083 8.919 1.00 1.00 H +ATOM 1352 P U A 43 -10.752 -40.256 5.662 1.00 1.00 P +ATOM 1353 OP1 U A 43 -11.830 -40.710 4.757 1.00 1.00 O +ATOM 1354 OP2 U A 43 -10.644 -40.825 7.024 1.00 1.00 O +ATOM 1355 O5' U A 43 -9.338 -40.479 4.910 1.00 1.00 O +ATOM 1356 C5' U A 43 -9.218 -40.265 3.497 1.00 1.00 C +ATOM 1357 C4' U A 43 -7.857 -40.717 2.960 1.00 1.00 C +ATOM 1358 O4' U A 43 -6.824 -39.943 3.565 1.00 1.00 O +ATOM 1359 C3' U A 43 -7.531 -42.178 3.229 1.00 1.00 C +ATOM 1360 O3' U A 43 -7.941 -43.010 2.138 1.00 1.00 O +ATOM 1361 C2' U A 43 -6.016 -42.187 3.390 1.00 1.00 C +ATOM 1362 O2' U A 43 -5.361 -42.531 2.167 1.00 1.00 O +ATOM 1363 C1' U A 43 -5.676 -40.767 3.814 1.00 1.00 C +ATOM 1364 N1 U A 43 -5.362 -40.653 5.246 1.00 1.00 N +ATOM 1365 C2 U A 43 -4.034 -40.651 5.630 1.00 1.00 C +ATOM 1366 O2 U A 43 -3.117 -40.731 4.815 1.00 1.00 O +ATOM 1367 N3 U A 43 -3.795 -40.554 6.989 1.00 1.00 N +ATOM 1368 C4 U A 43 -4.754 -40.460 7.982 1.00 1.00 C +ATOM 1369 O4 U A 43 -4.426 -40.373 9.165 1.00 1.00 O +ATOM 1370 C5 U A 43 -6.113 -40.470 7.490 1.00 1.00 C +ATOM 1371 C6 U A 43 -6.372 -40.563 6.163 1.00 1.00 C +ATOM 1372 H5' U A 43 -9.346 -39.202 3.287 1.00 1.00 H +ATOM 1373 H5'' U A 43 -10.002 -40.823 2.986 1.00 1.00 H +ATOM 1374 H4' U A 43 -7.829 -40.543 1.886 1.00 1.00 H +ATOM 1375 H3' U A 43 -8.008 -42.501 4.159 1.00 1.00 H +ATOM 1376 HO3' U A 43 -7.144 -43.372 1.742 1.00 1.00 H +ATOM 1377 H2' U A 43 -5.731 -42.878 4.187 1.00 1.00 H +ATOM 1378 HO2' U A 43 -4.493 -42.123 2.185 1.00 1.00 H +ATOM 1379 H1' U A 43 -4.836 -40.408 3.226 1.00 1.00 H +ATOM 1380 H3 U A 43 -2.829 -40.550 7.284 1.00 1.00 H +ATOM 1381 H5 U A 43 -6.941 -40.401 8.194 1.00 1.00 H +ATOM 1382 H6 U A 43 -7.406 -40.569 5.819 1.00 1.00 H +TER 1383 U A 43 +ATOM 1384 O5' G B 44 -4.988 36.675 15.579 1.00 1.00 O +ATOM 1385 C5' G B 44 -6.174 37.328 15.122 1.00 1.00 C +ATOM 1386 C4' G B 44 -5.875 38.271 13.959 1.00 1.00 C +ATOM 1387 O4' G B 44 -5.119 39.390 14.431 1.00 1.00 O +ATOM 1388 C3' G B 44 -5.077 37.624 12.832 1.00 1.00 C +ATOM 1389 O3' G B 44 -5.960 37.221 11.780 1.00 1.00 O +ATOM 1390 C2' G B 44 -4.171 38.739 12.342 1.00 1.00 C +ATOM 1391 O2' G B 44 -4.783 39.482 11.282 1.00 1.00 O +ATOM 1392 C1' G B 44 -3.983 39.595 13.585 1.00 1.00 C +ATOM 1393 N9 G B 44 -2.782 39.258 14.367 1.00 1.00 N +ATOM 1394 C8 G B 44 -2.694 38.642 15.588 1.00 1.00 C +ATOM 1395 N7 G B 44 -1.473 38.497 16.022 1.00 1.00 N +ATOM 1396 C5 G B 44 -0.691 39.058 15.016 1.00 1.00 C +ATOM 1397 C6 G B 44 0.722 39.189 14.928 1.00 1.00 C +ATOM 1398 O6 G B 44 1.574 38.827 15.736 1.00 1.00 O +ATOM 1399 N1 G B 44 1.102 39.815 13.748 1.00 1.00 N +ATOM 1400 C2 G B 44 0.236 40.260 12.773 1.00 1.00 C +ATOM 1401 N2 G B 44 0.793 40.837 11.709 1.00 1.00 N +ATOM 1402 N3 G B 44 -1.093 40.136 12.853 1.00 1.00 N +ATOM 1403 C4 G B 44 -1.484 39.528 13.998 1.00 1.00 C +ATOM 1404 H5' G B 44 -6.607 37.894 15.951 1.00 1.00 H +ATOM 1405 H5'' G B 44 -6.890 36.581 14.792 1.00 1.00 H +ATOM 1406 H4' G B 44 -6.816 38.640 13.556 1.00 1.00 H +ATOM 1407 H3' G B 44 -4.491 36.781 13.204 1.00 1.00 H +ATOM 1408 H2' G B 44 -3.210 38.327 12.024 1.00 1.00 H +ATOM 1409 HO2' G B 44 -5.692 39.647 11.538 1.00 1.00 H +ATOM 1410 H1' G B 44 -3.935 40.645 13.295 1.00 1.00 H +ATOM 1411 H8 G B 44 -3.566 38.305 16.148 1.00 1.00 H +ATOM 1412 H1 G B 44 2.095 39.944 13.614 1.00 1.00 H +ATOM 1413 H21 G B 44 1.798 40.929 11.651 1.00 1.00 H +ATOM 1414 H22 G B 44 0.211 41.185 10.959 1.00 1.00 H +ATOM 1415 HO5' G B 44 -4.259 36.997 15.042 1.00 1.00 H +ATOM 1416 P G B 45 -5.639 35.908 10.903 1.00 1.00 P +ATOM 1417 OP1 G B 45 -6.637 35.823 9.814 1.00 1.00 O +ATOM 1418 OP2 G B 45 -5.459 34.767 11.828 1.00 1.00 O +ATOM 1419 O5' G B 45 -4.208 36.258 10.251 1.00 1.00 O +ATOM 1420 C5' G B 45 -4.075 37.335 9.318 1.00 1.00 C +ATOM 1421 C4' G B 45 -2.609 37.665 9.048 1.00 1.00 C +ATOM 1422 O4' G B 45 -1.954 37.995 10.270 1.00 1.00 O +ATOM 1423 C3' G B 45 -1.817 36.525 8.425 1.00 1.00 C +ATOM 1424 O3' G B 45 -1.861 36.637 6.996 1.00 1.00 O +ATOM 1425 C2' G B 45 -0.398 36.756 8.926 1.00 1.00 C +ATOM 1426 O2' G B 45 0.387 37.470 7.966 1.00 1.00 O +ATOM 1427 C1' G B 45 -0.587 37.568 10.206 1.00 1.00 C +ATOM 1428 N9 G B 45 -0.299 36.807 11.431 1.00 1.00 N +ATOM 1429 C8 G B 45 -1.176 36.237 12.318 1.00 1.00 C +ATOM 1430 N7 G B 45 -0.597 35.649 13.327 1.00 1.00 N +ATOM 1431 C5 G B 45 0.762 35.841 13.094 1.00 1.00 C +ATOM 1432 C6 G B 45 1.886 35.420 13.858 1.00 1.00 C +ATOM 1433 O6 G B 45 1.901 34.783 14.909 1.00 1.00 O +ATOM 1434 N1 G B 45 3.079 35.821 13.270 1.00 1.00 N +ATOM 1435 C2 G B 45 3.181 36.535 12.095 1.00 1.00 C +ATOM 1436 N2 G B 45 4.415 36.829 11.687 1.00 1.00 N +ATOM 1437 N3 G B 45 2.126 36.932 11.377 1.00 1.00 N +ATOM 1438 C4 G B 45 0.953 36.550 11.935 1.00 1.00 C +ATOM 1439 H5' G B 45 -4.569 38.217 9.720 1.00 1.00 H +ATOM 1440 H5'' G B 45 -4.555 37.054 8.380 1.00 1.00 H +ATOM 1441 H4' G B 45 -2.558 38.530 8.390 1.00 1.00 H +ATOM 1442 H3' G B 45 -2.196 35.558 8.760 1.00 1.00 H +ATOM 1443 H2' G B 45 0.067 35.802 9.170 1.00 1.00 H +ATOM 1444 HO2' G B 45 0.818 38.191 8.430 1.00 1.00 H +ATOM 1445 H1' G B 45 0.064 38.443 10.177 1.00 1.00 H +ATOM 1446 H8 G B 45 -2.257 36.271 12.190 1.00 1.00 H +ATOM 1447 H1 G B 45 3.924 35.558 13.755 1.00 1.00 H +ATOM 1448 H21 G B 45 5.214 36.525 12.233 1.00 1.00 H +ATOM 1449 H22 G B 45 4.553 37.350 10.834 1.00 1.00 H +ATOM 1450 P G B 46 -1.721 35.332 6.058 1.00 1.00 P +ATOM 1451 OP1 G B 46 -2.147 35.701 4.690 1.00 1.00 O +ATOM 1452 OP2 G B 46 -2.368 34.196 6.749 1.00 1.00 O +ATOM 1453 O5' G B 46 -0.131 35.066 6.033 1.00 1.00 O +ATOM 1454 C5' G B 46 0.743 35.947 5.319 1.00 1.00 C +ATOM 1455 C4' G B 46 2.211 35.636 5.606 1.00 1.00 C +ATOM 1456 O4' G B 46 2.448 35.703 7.010 1.00 1.00 O +ATOM 1457 C3' G B 46 2.658 34.253 5.153 1.00 1.00 C +ATOM 1458 O3' G B 46 3.209 34.326 3.830 1.00 1.00 O +ATOM 1459 C2' G B 46 3.750 33.884 6.144 1.00 1.00 C +ATOM 1460 O2' G B 46 5.049 34.191 5.626 1.00 1.00 O +ATOM 1461 C1' G B 46 3.431 34.729 7.375 1.00 1.00 C +ATOM 1462 N9 G B 46 2.890 33.949 8.503 1.00 1.00 N +ATOM 1463 C8 G B 46 1.587 33.639 8.793 1.00 1.00 C +ATOM 1464 N7 G B 46 1.439 32.946 9.888 1.00 1.00 N +ATOM 1465 C5 G B 46 2.738 32.784 10.360 1.00 1.00 C +ATOM 1466 C6 G B 46 3.209 32.112 11.522 1.00 1.00 C +ATOM 1467 O6 G B 46 2.557 31.517 12.377 1.00 1.00 O +ATOM 1468 N1 G B 46 4.592 32.185 11.627 1.00 1.00 N +ATOM 1469 C2 G B 46 5.421 32.823 10.729 1.00 1.00 C +ATOM 1470 N2 G B 46 6.724 32.786 10.998 1.00 1.00 N +ATOM 1471 N3 G B 46 4.980 33.456 9.637 1.00 1.00 N +ATOM 1472 C4 G B 46 3.634 33.396 9.518 1.00 1.00 C +ATOM 1473 H5' G B 46 0.532 36.975 5.615 1.00 1.00 H +ATOM 1474 H5'' G B 46 0.560 35.841 4.250 1.00 1.00 H +ATOM 1475 H4' G B 46 2.831 36.385 5.116 1.00 1.00 H +ATOM 1476 H3' G B 46 1.832 33.540 5.202 1.00 1.00 H +ATOM 1477 H2' G B 46 3.677 32.827 6.396 1.00 1.00 H +ATOM 1478 HO2' G B 46 5.026 35.099 5.316 1.00 1.00 H +ATOM 1479 H1' G B 46 4.337 35.239 7.703 1.00 1.00 H +ATOM 1480 H8 G B 46 0.749 33.943 8.166 1.00 1.00 H +ATOM 1481 H1 G B 46 5.002 31.729 12.429 1.00 1.00 H +ATOM 1482 H21 G B 46 7.055 32.306 11.825 1.00 1.00 H +ATOM 1483 H22 G B 46 7.382 33.236 10.378 1.00 1.00 H +ATOM 1484 P A B 47 3.147 33.051 2.842 1.00 1.00 P +ATOM 1485 OP1 A B 47 3.377 33.529 1.461 1.00 1.00 O +ATOM 1486 OP2 A B 47 1.924 32.279 3.160 1.00 1.00 O +ATOM 1487 O5' A B 47 4.425 32.173 3.284 1.00 1.00 O +ATOM 1488 C5' A B 47 5.753 32.587 2.943 1.00 1.00 C +ATOM 1489 C4' A B 47 6.801 31.619 3.489 1.00 1.00 C +ATOM 1490 O4' A B 47 6.782 31.650 4.913 1.00 1.00 O +ATOM 1491 C3' A B 47 6.591 30.171 3.071 1.00 1.00 C +ATOM 1492 O3' A B 47 7.384 29.886 1.912 1.00 1.00 O +ATOM 1493 C2' A B 47 7.108 29.373 4.260 1.00 1.00 C +ATOM 1494 O2' A B 47 8.491 29.036 4.100 1.00 1.00 O +ATOM 1495 C1' A B 47 6.900 30.320 5.438 1.00 1.00 C +ATOM 1496 N9 A B 47 5.677 30.049 6.212 1.00 1.00 N +ATOM 1497 C8 A B 47 4.386 30.423 5.936 1.00 1.00 C +ATOM 1498 N7 A B 47 3.519 30.025 6.826 1.00 1.00 N +ATOM 1499 C5 A B 47 4.290 29.337 7.757 1.00 1.00 C +ATOM 1500 C6 A B 47 3.965 28.669 8.949 1.00 1.00 C +ATOM 1501 N6 A B 47 2.721 28.584 9.421 1.00 1.00 N +ATOM 1502 N1 A B 47 4.973 28.094 9.629 1.00 1.00 N +ATOM 1503 C2 A B 47 6.208 28.183 9.152 1.00 1.00 C +ATOM 1504 N3 A B 47 6.640 28.780 8.050 1.00 1.00 N +ATOM 1505 C4 A B 47 5.606 29.347 7.391 1.00 1.00 C +ATOM 1506 H5' A B 47 5.934 33.578 3.359 1.00 1.00 H +ATOM 1507 H5'' A B 47 5.843 32.634 1.858 1.00 1.00 H +ATOM 1508 H4' A B 47 7.785 31.942 3.154 1.00 1.00 H +ATOM 1509 H3' A B 47 5.535 29.965 2.892 1.00 1.00 H +ATOM 1510 H2' A B 47 6.504 28.474 4.396 1.00 1.00 H +ATOM 1511 HO2' A B 47 8.883 29.019 4.977 1.00 1.00 H +ATOM 1512 H1' A B 47 7.763 30.267 6.101 1.00 1.00 H +ATOM 1513 H8 A B 47 4.109 31.001 5.053 1.00 1.00 H +ATOM 1514 H61 A B 47 2.541 28.090 10.286 1.00 1.00 H +ATOM 1515 H62 A B 47 1.958 29.013 8.916 1.00 1.00 H +ATOM 1516 H2 A B 47 6.977 27.695 9.753 1.00 1.00 H +ATOM 1517 P U B 48 6.920 28.767 0.852 1.00 1.00 P +ATOM 1518 OP1 U B 48 7.985 28.624 -0.165 1.00 1.00 O +ATOM 1519 OP2 U B 48 5.535 29.075 0.429 1.00 1.00 O +ATOM 1520 O5' U B 48 6.887 27.422 1.737 1.00 1.00 O +ATOM 1521 C5' U B 48 8.093 26.864 2.269 1.00 1.00 C +ATOM 1522 C4' U B 48 7.799 25.693 3.199 1.00 1.00 C +ATOM 1523 O4' U B 48 7.119 26.160 4.357 1.00 1.00 O +ATOM 1524 C3' U B 48 6.922 24.618 2.585 1.00 1.00 C +ATOM 1525 O3' U B 48 7.747 23.615 1.986 1.00 1.00 O +ATOM 1526 C2' U B 48 6.173 24.035 3.778 1.00 1.00 C +ATOM 1527 O2' U B 48 6.823 22.863 4.278 1.00 1.00 O +ATOM 1528 C1' U B 48 6.190 25.167 4.811 1.00 1.00 C +ATOM 1529 N1 U B 48 4.884 25.842 4.985 1.00 1.00 N +ATOM 1530 C2 U B 48 4.100 25.467 6.057 1.00 1.00 C +ATOM 1531 O2 U B 48 4.455 24.602 6.856 1.00 1.00 O +ATOM 1532 N3 U B 48 2.888 26.121 6.184 1.00 1.00 N +ATOM 1533 C4 U B 48 2.401 27.104 5.341 1.00 1.00 C +ATOM 1534 O4 U B 48 1.304 27.621 5.549 1.00 1.00 O +ATOM 1535 C5 U B 48 3.286 27.434 4.246 1.00 1.00 C +ATOM 1536 C6 U B 48 4.478 26.805 4.102 1.00 1.00 C +ATOM 1537 H5' U B 48 8.625 27.634 2.826 1.00 1.00 H +ATOM 1538 H5'' U B 48 8.720 26.520 1.447 1.00 1.00 H +ATOM 1539 H4' U B 48 8.741 25.246 3.511 1.00 1.00 H +ATOM 1540 H3' U B 48 6.228 25.048 1.860 1.00 1.00 H +ATOM 1541 H2' U B 48 5.140 23.810 3.492 1.00 1.00 H +ATOM 1542 HO2' U B 48 6.146 22.196 4.411 1.00 1.00 H +ATOM 1543 H1' U B 48 6.526 24.773 5.770 1.00 1.00 H +ATOM 1544 H3 U B 48 2.305 25.857 6.965 1.00 1.00 H +ATOM 1545 H5 U B 48 2.990 28.198 3.527 1.00 1.00 H +ATOM 1546 H6 U B 48 5.125 27.072 3.268 1.00 1.00 H +ATOM 1547 P A B 49 7.139 22.609 0.887 1.00 1.00 P +ATOM 1548 OP1 A B 49 7.615 23.034 -0.448 1.00 1.00 O +ATOM 1549 OP2 A B 49 5.691 22.473 1.148 1.00 1.00 O +ATOM 1550 O5' A B 49 7.853 21.215 1.259 1.00 1.00 O +ATOM 1551 C5' A B 49 9.203 21.206 1.725 1.00 1.00 C +ATOM 1552 C4' A B 49 9.354 20.383 3.002 1.00 1.00 C +ATOM 1553 O4' A B 49 8.223 20.612 3.851 1.00 1.00 O +ATOM 1554 C3' A B 49 9.462 18.877 2.768 1.00 1.00 C +ATOM 1555 O3' A B 49 10.480 18.339 3.620 1.00 1.00 O +ATOM 1556 C2' A B 49 8.106 18.319 3.180 1.00 1.00 C +ATOM 1557 O2' A B 49 8.246 17.057 3.845 1.00 1.00 O +ATOM 1558 C1' A B 49 7.543 19.377 4.120 1.00 1.00 C +ATOM 1559 N9 A B 49 6.096 19.619 3.960 1.00 1.00 N +ATOM 1560 C8 A B 49 5.377 19.818 2.810 1.00 1.00 C +ATOM 1561 N7 A B 49 4.101 20.003 3.012 1.00 1.00 N +ATOM 1562 C5 A B 49 3.967 19.920 4.394 1.00 1.00 C +ATOM 1563 C6 A B 49 2.859 20.030 5.251 1.00 1.00 C +ATOM 1564 N6 A B 49 1.620 20.259 4.815 1.00 1.00 N +ATOM 1565 N1 A B 49 3.083 19.893 6.568 1.00 1.00 N +ATOM 1566 C2 A B 49 4.319 19.665 6.996 1.00 1.00 C +ATOM 1567 N3 A B 49 5.436 19.542 6.296 1.00 1.00 N +ATOM 1568 C4 A B 49 5.179 19.684 4.979 1.00 1.00 C +ATOM 1569 H5' A B 49 9.516 22.230 1.926 1.00 1.00 H +ATOM 1570 H5'' A B 49 9.845 20.785 0.951 1.00 1.00 H +ATOM 1571 H4' A B 49 10.248 20.720 3.522 1.00 1.00 H +ATOM 1572 H3' A B 49 9.670 18.658 1.720 1.00 1.00 H +ATOM 1573 H2' A B 49 7.462 18.222 2.301 1.00 1.00 H +ATOM 1574 HO2' A B 49 7.821 16.395 3.294 1.00 1.00 H +ATOM 1575 H1' A B 49 7.735 19.078 5.147 1.00 1.00 H +ATOM 1576 H8 A B 49 5.829 19.820 1.818 1.00 1.00 H +ATOM 1577 H61 A B 49 0.863 20.326 5.480 1.00 1.00 H +ATOM 1578 H62 A B 49 1.429 20.363 3.825 1.00 1.00 H +ATOM 1579 H2 A B 49 4.429 19.562 8.076 1.00 1.00 H +ATOM 1580 P U B 50 10.868 16.778 3.548 1.00 1.00 P +ATOM 1581 OP1 U B 50 12.337 16.673 3.399 1.00 1.00 O +ATOM 1582 OP2 U B 50 9.978 16.123 2.563 1.00 1.00 O +ATOM 1583 O5' U B 50 10.471 16.249 5.013 1.00 1.00 O +ATOM 1584 C5' U B 50 11.473 15.729 5.893 1.00 1.00 C +ATOM 1585 C4' U B 50 10.847 14.927 7.037 1.00 1.00 C +ATOM 1586 O4' U B 50 11.104 15.582 8.272 1.00 1.00 O +ATOM 1587 C3' U B 50 9.333 14.762 6.916 1.00 1.00 C +ATOM 1588 O3' U B 50 8.982 13.402 7.177 1.00 1.00 O +ATOM 1589 C2' U B 50 8.740 15.646 8.015 1.00 1.00 C +ATOM 1590 O2' U B 50 8.041 14.859 8.985 1.00 1.00 O +ATOM 1591 C1' U B 50 9.952 16.334 8.637 1.00 1.00 C +ATOM 1592 N1 U B 50 10.176 17.722 8.179 1.00 1.00 N +ATOM 1593 C2 U B 50 10.682 18.617 9.103 1.00 1.00 C +ATOM 1594 O2 U B 50 10.937 18.289 10.260 1.00 1.00 O +ATOM 1595 N3 U B 50 10.883 19.908 8.650 1.00 1.00 N +ATOM 1596 C4 U B 50 10.626 20.374 7.372 1.00 1.00 C +ATOM 1597 O4 U B 50 10.845 21.548 7.078 1.00 1.00 O +ATOM 1598 C5 U B 50 10.099 19.371 6.475 1.00 1.00 C +ATOM 1599 C6 U B 50 9.894 18.100 6.895 1.00 1.00 C +ATOM 1600 H5' U B 50 12.043 16.559 6.312 1.00 1.00 H +ATOM 1601 H5'' U B 50 12.146 15.085 5.325 1.00 1.00 H +ATOM 1602 H4' U B 50 11.308 13.939 7.071 1.00 1.00 H +ATOM 1603 H3' U B 50 8.982 15.077 5.933 1.00 1.00 H +ATOM 1604 H2' U B 50 8.070 16.390 7.576 1.00 1.00 H +ATOM 1605 HO2' U B 50 7.823 15.439 9.719 1.00 1.00 H +ATOM 1606 H1' U B 50 9.845 16.322 9.721 1.00 1.00 H +ATOM 1607 H3 U B 50 11.252 20.573 9.314 1.00 1.00 H +ATOM 1608 H5 U B 50 9.864 19.641 5.446 1.00 1.00 H +ATOM 1609 H6 U B 50 9.494 17.364 6.197 1.00 1.00 H +ATOM 1610 P G B 51 7.542 12.844 6.741 1.00 1.00 P +ATOM 1611 OP1 G B 51 7.430 11.438 7.186 1.00 1.00 O +ATOM 1612 OP2 G B 51 7.333 13.188 5.316 1.00 1.00 O +ATOM 1613 O5' G B 51 6.535 13.736 7.630 1.00 1.00 O +ATOM 1614 C5' G B 51 5.825 14.839 7.053 1.00 1.00 C +ATOM 1615 C4' G B 51 4.526 14.388 6.389 1.00 1.00 C +ATOM 1616 O4' G B 51 3.925 15.496 5.715 1.00 1.00 O +ATOM 1617 C3' G B 51 4.720 13.285 5.361 1.00 1.00 C +ATOM 1618 O3' G B 51 4.415 12.018 5.946 1.00 1.00 O +ATOM 1619 C2' G B 51 3.709 13.595 4.273 1.00 1.00 C +ATOM 1620 O2' G B 51 2.510 12.831 4.436 1.00 1.00 O +ATOM 1621 C1' G B 51 3.449 15.085 4.424 1.00 1.00 C +ATOM 1622 N9 G B 51 4.142 15.898 3.412 1.00 1.00 N +ATOM 1623 C8 G B 51 5.332 16.570 3.524 1.00 1.00 C +ATOM 1624 N7 G B 51 5.684 17.208 2.443 1.00 1.00 N +ATOM 1625 C5 G B 51 4.653 16.942 1.547 1.00 1.00 C +ATOM 1626 C6 G B 51 4.484 17.372 0.202 1.00 1.00 C +ATOM 1627 O6 G B 51 5.226 18.084 -0.472 1.00 1.00 O +ATOM 1628 N1 G B 51 3.308 16.879 -0.346 1.00 1.00 N +ATOM 1629 C2 G B 51 2.404 16.074 0.315 1.00 1.00 C +ATOM 1630 N2 G B 51 1.330 15.702 -0.381 1.00 1.00 N +ATOM 1631 N3 G B 51 2.560 15.668 1.580 1.00 1.00 N +ATOM 1632 C4 G B 51 3.704 16.139 2.130 1.00 1.00 C +ATOM 1633 H5' G B 51 6.459 15.315 6.306 1.00 1.00 H +ATOM 1634 H5'' G B 51 5.593 15.560 7.835 1.00 1.00 H +ATOM 1635 H4' G B 51 3.840 14.037 7.160 1.00 1.00 H +ATOM 1636 H3' G B 51 5.731 13.303 4.957 1.00 1.00 H +ATOM 1637 H2' G B 51 4.160 13.406 3.298 1.00 1.00 H +ATOM 1638 HO2' G B 51 2.551 12.417 5.301 1.00 1.00 H +ATOM 1639 H1' G B 51 2.380 15.273 4.360 1.00 1.00 H +ATOM 1640 H8 G B 51 5.929 16.571 4.436 1.00 1.00 H +ATOM 1641 H1 G B 51 3.117 17.143 -1.302 1.00 1.00 H +ATOM 1642 H21 G B 51 1.217 16.010 -1.333 1.00 1.00 H +ATOM 1643 H22 G B 51 0.633 15.115 0.042 1.00 1.00 H +ATOM 1644 P G B 52 4.681 10.667 5.115 1.00 1.00 P +ATOM 1645 OP1 G B 52 4.133 9.530 5.888 1.00 1.00 O +ATOM 1646 OP2 G B 52 6.097 10.657 4.687 1.00 1.00 O +ATOM 1647 O5' G B 52 3.761 10.883 3.813 1.00 1.00 O +ATOM 1648 C5' G B 52 4.319 10.759 2.506 1.00 1.00 C +ATOM 1649 C4' G B 52 3.250 10.895 1.425 1.00 1.00 C +ATOM 1650 O4' G B 52 2.956 12.279 1.189 1.00 1.00 O +ATOM 1651 C3' G B 52 3.657 10.294 0.088 1.00 1.00 C +ATOM 1652 O3' G B 52 3.196 8.939 0.005 1.00 1.00 O +ATOM 1653 C2' G B 52 2.921 11.150 -0.923 1.00 1.00 C +ATOM 1654 O2' G B 52 1.636 10.603 -1.237 1.00 1.00 O +ATOM 1655 C1' G B 52 2.795 12.494 -0.221 1.00 1.00 C +ATOM 1656 N9 G B 52 3.800 13.483 -0.652 1.00 1.00 N +ATOM 1657 C8 G B 52 4.747 14.135 0.097 1.00 1.00 C +ATOM 1658 N7 G B 52 5.481 14.967 -0.588 1.00 1.00 N +ATOM 1659 C5 G B 52 4.987 14.861 -1.885 1.00 1.00 C +ATOM 1660 C6 G B 52 5.393 15.529 -3.073 1.00 1.00 C +ATOM 1661 O6 G B 52 6.286 16.363 -3.213 1.00 1.00 O +ATOM 1662 N1 G B 52 4.633 15.133 -4.165 1.00 1.00 N +ATOM 1663 C2 G B 52 3.610 14.209 -4.125 1.00 1.00 C +ATOM 1664 N2 G B 52 2.995 13.959 -5.280 1.00 1.00 N +ATOM 1665 N3 G B 52 3.228 13.580 -3.009 1.00 1.00 N +ATOM 1666 C4 G B 52 3.958 13.954 -1.933 1.00 1.00 C +ATOM 1667 H5' G B 52 4.795 9.782 2.413 1.00 1.00 H +ATOM 1668 H5'' G B 52 5.070 11.536 2.362 1.00 1.00 H +ATOM 1669 H4' G B 52 2.341 10.405 1.769 1.00 1.00 H +ATOM 1670 H3' G B 52 4.737 10.358 -0.057 1.00 1.00 H +ATOM 1671 H2' G B 52 3.522 11.263 -1.824 1.00 1.00 H +ATOM 1672 HO2' G B 52 1.090 11.324 -1.562 1.00 1.00 H +ATOM 1673 H1' G B 52 1.800 12.900 -0.407 1.00 1.00 H +ATOM 1674 H8 G B 52 4.873 13.975 1.168 1.00 1.00 H +ATOM 1675 H1 G B 52 4.862 15.566 -5.048 1.00 1.00 H +ATOM 1676 H21 G B 52 3.287 14.438 -6.125 1.00 1.00 H +ATOM 1677 H22 G B 52 2.237 13.291 -5.313 1.00 1.00 H +ATOM 1678 P A B 53 4.199 7.758 -0.438 1.00 1.00 P +ATOM 1679 OP1 A B 53 3.600 6.467 -0.030 1.00 1.00 O +ATOM 1680 OP2 A B 53 5.563 8.112 0.016 1.00 1.00 O +ATOM 1681 O5' A B 53 4.166 7.841 -2.046 1.00 1.00 O +ATOM 1682 C5' A B 53 2.971 7.529 -2.765 1.00 1.00 C +ATOM 1683 C4' A B 53 3.074 7.936 -4.232 1.00 1.00 C +ATOM 1684 O4' A B 53 3.208 9.349 -4.344 1.00 1.00 O +ATOM 1685 C3' A B 53 4.261 7.340 -4.972 1.00 1.00 C +ATOM 1686 O3' A B 53 3.894 6.074 -5.532 1.00 1.00 O +ATOM 1687 C2' A B 53 4.526 8.344 -6.083 1.00 1.00 C +ATOM 1688 O2' A B 53 3.884 7.952 -7.302 1.00 1.00 O +ATOM 1689 C1' A B 53 3.937 9.650 -5.541 1.00 1.00 C +ATOM 1690 N9 A B 53 4.948 10.668 -5.206 1.00 1.00 N +ATOM 1691 C8 A B 53 5.515 10.960 -3.992 1.00 1.00 C +ATOM 1692 N7 A B 53 6.388 11.930 -4.036 1.00 1.00 N +ATOM 1693 C5 A B 53 6.400 12.305 -5.377 1.00 1.00 C +ATOM 1694 C6 A B 53 7.121 13.283 -6.082 1.00 1.00 C +ATOM 1695 N6 A B 53 8.005 14.098 -5.504 1.00 1.00 N +ATOM 1696 N1 A B 53 6.891 13.386 -7.402 1.00 1.00 N +ATOM 1697 C2 A B 53 6.010 12.572 -7.971 1.00 1.00 C +ATOM 1698 N3 A B 53 5.274 11.619 -7.420 1.00 1.00 N +ATOM 1699 C4 A B 53 5.527 11.540 -6.097 1.00 1.00 C +ATOM 1700 H5' A B 53 2.133 8.055 -2.309 1.00 1.00 H +ATOM 1701 H5'' A B 53 2.790 6.456 -2.707 1.00 1.00 H +ATOM 1702 H4' A B 53 2.159 7.640 -4.742 1.00 1.00 H +ATOM 1703 H3' A B 53 5.126 7.251 -4.313 1.00 1.00 H +ATOM 1704 H2' A B 53 5.602 8.457 -6.233 1.00 1.00 H +ATOM 1705 HO2' A B 53 4.349 8.387 -8.022 1.00 1.00 H +ATOM 1706 H1' A B 53 3.252 10.064 -6.280 1.00 1.00 H +ATOM 1707 H8 A B 53 5.260 10.431 -3.073 1.00 1.00 H +ATOM 1708 H61 A B 53 8.497 14.787 -6.060 1.00 1.00 H +ATOM 1709 H62 A B 53 8.183 14.027 -4.513 1.00 1.00 H +ATOM 1710 H2 A B 53 5.872 12.709 -9.044 1.00 1.00 H +ATOM 1711 P A B 54 5.019 4.999 -5.950 1.00 1.00 P +ATOM 1712 OP1 A B 54 4.333 3.768 -6.404 1.00 1.00 O +ATOM 1713 OP2 A B 54 6.026 4.929 -4.868 1.00 1.00 O +ATOM 1714 O5' A B 54 5.701 5.683 -7.235 1.00 1.00 O +ATOM 1715 C5' A B 54 4.934 5.886 -8.424 1.00 1.00 C +ATOM 1716 C4' A B 54 5.589 6.896 -9.357 1.00 1.00 C +ATOM 1717 O4' A B 54 5.840 8.115 -8.660 1.00 1.00 O +ATOM 1718 C3' A B 54 6.930 6.456 -9.921 1.00 1.00 C +ATOM 1719 O3' A B 54 6.737 5.732 -11.141 1.00 1.00 O +ATOM 1720 C2' A B 54 7.626 7.766 -10.219 1.00 1.00 C +ATOM 1721 O2' A B 54 7.439 8.149 -11.588 1.00 1.00 O +ATOM 1722 C1' A B 54 6.963 8.762 -9.269 1.00 1.00 C +ATOM 1723 N9 A B 54 7.856 9.246 -8.199 1.00 1.00 N +ATOM 1724 C8 A B 54 8.223 8.633 -7.027 1.00 1.00 C +ATOM 1725 N7 A B 54 9.059 9.328 -6.307 1.00 1.00 N +ATOM 1726 C5 A B 54 9.260 10.485 -7.054 1.00 1.00 C +ATOM 1727 C6 A B 54 10.044 11.629 -6.839 1.00 1.00 C +ATOM 1728 N6 A B 54 10.808 11.796 -5.759 1.00 1.00 N +ATOM 1729 N1 A B 54 10.011 12.586 -7.781 1.00 1.00 N +ATOM 1730 C2 A B 54 9.252 12.410 -8.856 1.00 1.00 C +ATOM 1731 N3 A B 54 8.475 11.384 -9.172 1.00 1.00 N +ATOM 1732 C4 A B 54 8.530 10.442 -8.208 1.00 1.00 C +ATOM 1733 H5' A B 54 3.944 6.249 -8.148 1.00 1.00 H +ATOM 1734 H5'' A B 54 4.832 4.935 -8.946 1.00 1.00 H +ATOM 1735 H4' A B 54 4.911 7.105 -10.182 1.00 1.00 H +ATOM 1736 H3' A B 54 7.492 5.871 -9.191 1.00 1.00 H +ATOM 1737 H2' A B 54 8.690 7.682 -9.986 1.00 1.00 H +ATOM 1738 HO2' A B 54 6.519 8.402 -11.688 1.00 1.00 H +ATOM 1739 H1' A B 54 6.610 9.618 -9.844 1.00 1.00 H +ATOM 1740 H8 A B 54 7.851 7.653 -6.727 1.00 1.00 H +ATOM 1741 H61 A B 54 11.353 12.638 -5.653 1.00 1.00 H +ATOM 1742 H62 A B 54 10.842 11.083 -5.050 1.00 1.00 H +ATOM 1743 H2 A B 54 9.272 13.224 -9.581 1.00 1.00 H +ATOM 1744 P G B 55 7.957 4.913 -11.806 1.00 1.00 P +ATOM 1745 OP1 G B 55 7.419 4.113 -12.929 1.00 1.00 O +ATOM 1746 OP2 G B 55 8.711 4.244 -10.721 1.00 1.00 O +ATOM 1747 O5' G B 55 8.891 6.077 -12.422 1.00 1.00 O +ATOM 1748 C5' G B 55 8.597 6.650 -13.704 1.00 1.00 C +ATOM 1749 C4' G B 55 9.824 7.331 -14.316 1.00 1.00 C +ATOM 1750 O4' G B 55 9.851 8.718 -13.961 1.00 1.00 O +ATOM 1751 C3' G B 55 11.148 6.725 -13.870 1.00 1.00 C +ATOM 1752 O3' G B 55 11.582 5.753 -14.826 1.00 1.00 O +ATOM 1753 C2' G B 55 12.098 7.909 -13.863 1.00 1.00 C +ATOM 1754 O2' G B 55 12.749 8.064 -15.129 1.00 1.00 O +ATOM 1755 C1' G B 55 11.179 9.087 -13.564 1.00 1.00 C +ATOM 1756 N9 G B 55 11.124 9.455 -12.139 1.00 1.00 N +ATOM 1757 C8 G B 55 10.032 9.485 -11.310 1.00 1.00 C +ATOM 1758 N7 G B 55 10.306 9.844 -10.088 1.00 1.00 N +ATOM 1759 C5 G B 55 11.679 10.070 -10.105 1.00 1.00 C +ATOM 1760 C6 G B 55 12.546 10.485 -9.057 1.00 1.00 C +ATOM 1761 O6 G B 55 12.264 10.740 -7.888 1.00 1.00 O +ATOM 1762 N1 G B 55 13.859 10.590 -9.495 1.00 1.00 N +ATOM 1763 C2 G B 55 14.287 10.330 -10.779 1.00 1.00 C +ATOM 1764 N2 G B 55 15.591 10.483 -11.007 1.00 1.00 N +ATOM 1765 N3 G B 55 13.475 9.942 -11.766 1.00 1.00 N +ATOM 1766 C4 G B 55 12.189 9.833 -11.357 1.00 1.00 C +ATOM 1767 H5' G B 55 7.801 7.386 -13.590 1.00 1.00 H +ATOM 1768 H5'' G B 55 8.258 5.861 -14.376 1.00 1.00 H +ATOM 1769 H4' G B 55 9.757 7.259 -15.399 1.00 1.00 H +ATOM 1770 H3' G B 55 11.060 6.291 -12.871 1.00 1.00 H +ATOM 1771 H2' G B 55 12.831 7.796 -13.062 1.00 1.00 H +ATOM 1772 HO2' G B 55 12.571 8.956 -15.435 1.00 1.00 H +ATOM 1773 H1' G B 55 11.502 9.954 -14.140 1.00 1.00 H +ATOM 1774 H8 G B 55 9.027 9.226 -11.643 1.00 1.00 H +ATOM 1775 H1 G B 55 14.536 10.881 -8.805 1.00 1.00 H +ATOM 1776 H21 G B 55 16.205 10.779 -10.257 1.00 1.00 H +ATOM 1777 H22 G B 55 15.968 10.309 -11.926 1.00 1.00 H +ATOM 1778 P A B 56 12.312 4.399 -14.344 1.00 1.00 P +ATOM 1779 OP1 A B 56 12.320 3.451 -15.481 1.00 1.00 O +ATOM 1780 OP2 A B 56 11.721 3.993 -13.049 1.00 1.00 O +ATOM 1781 O5' A B 56 13.826 4.877 -14.079 1.00 1.00 O +ATOM 1782 C5' A B 56 14.748 4.999 -15.167 1.00 1.00 C +ATOM 1783 C4' A B 56 16.108 5.515 -14.701 1.00 1.00 C +ATOM 1784 O4' A B 56 15.950 6.792 -14.085 1.00 1.00 O +ATOM 1785 C3' A B 56 16.806 4.612 -13.691 1.00 1.00 C +ATOM 1786 O3' A B 56 17.708 3.731 -14.374 1.00 1.00 O +ATOM 1787 C2' A B 56 17.586 5.591 -12.829 1.00 1.00 C +ATOM 1788 O2' A B 56 18.902 5.812 -13.349 1.00 1.00 O +ATOM 1789 C1' A B 56 16.741 6.856 -12.890 1.00 1.00 C +ATOM 1790 N9 A B 56 15.817 7.009 -11.750 1.00 1.00 N +ATOM 1791 C8 A B 56 14.538 6.533 -11.610 1.00 1.00 C +ATOM 1792 N7 A B 56 13.988 6.832 -10.465 1.00 1.00 N +ATOM 1793 C5 A B 56 14.972 7.556 -9.802 1.00 1.00 C +ATOM 1794 C6 A B 56 15.013 8.161 -8.534 1.00 1.00 C +ATOM 1795 N6 A B 56 13.993 8.124 -7.675 1.00 1.00 N +ATOM 1796 N1 A B 56 16.145 8.799 -8.191 1.00 1.00 N +ATOM 1797 C2 A B 56 17.157 8.829 -9.050 1.00 1.00 C +ATOM 1798 N3 A B 56 17.240 8.303 -10.263 1.00 1.00 N +ATOM 1799 C4 A B 56 16.090 7.670 -10.577 1.00 1.00 C +ATOM 1800 H5' A B 56 14.339 5.692 -15.902 1.00 1.00 H +ATOM 1801 H5'' A B 56 14.878 4.022 -15.632 1.00 1.00 H +ATOM 1802 H4' A B 56 16.752 5.632 -15.569 1.00 1.00 H +ATOM 1803 H3' A B 56 16.079 4.056 -13.094 1.00 1.00 H +ATOM 1804 H2' A B 56 17.633 5.229 -11.803 1.00 1.00 H +ATOM 1805 HO2' A B 56 19.517 5.698 -12.623 1.00 1.00 H +ATOM 1806 H1' A B 56 17.397 7.725 -12.935 1.00 1.00 H +ATOM 1807 H8 A B 56 14.029 5.957 -12.383 1.00 1.00 H +ATOM 1808 H61 A B 56 14.074 8.577 -6.772 1.00 1.00 H +ATOM 1809 H62 A B 56 13.138 7.646 -7.925 1.00 1.00 H +ATOM 1810 H2 A B 56 18.044 9.362 -8.709 1.00 1.00 H +ATOM 1811 P A B 57 17.925 2.214 -13.870 1.00 1.00 P +ATOM 1812 OP1 A B 57 18.771 1.516 -14.863 1.00 1.00 O +ATOM 1813 OP2 A B 57 16.604 1.656 -13.505 1.00 1.00 O +ATOM 1814 O5' A B 57 18.785 2.396 -12.520 1.00 1.00 O +ATOM 1815 C5' A B 57 20.198 2.613 -12.583 1.00 1.00 C +ATOM 1816 C4' A B 57 20.800 2.811 -11.193 1.00 1.00 C +ATOM 1817 O4' A B 57 20.270 3.991 -10.601 1.00 1.00 O +ATOM 1818 C3' A B 57 20.522 1.679 -10.217 1.00 1.00 C +ATOM 1819 O3' A B 57 21.562 0.696 -10.298 1.00 1.00 O +ATOM 1820 C2' A B 57 20.554 2.366 -8.863 1.00 1.00 C +ATOM 1821 O2' A B 57 21.855 2.292 -8.269 1.00 1.00 O +ATOM 1822 C1' A B 57 20.168 3.808 -9.181 1.00 1.00 C +ATOM 1823 N9 A B 57 18.788 4.149 -8.789 1.00 1.00 N +ATOM 1824 C8 A B 57 17.622 3.944 -9.479 1.00 1.00 C +ATOM 1825 N7 A B 57 16.558 4.373 -8.857 1.00 1.00 N +ATOM 1826 C5 A B 57 17.057 4.900 -7.669 1.00 1.00 C +ATOM 1827 C6 A B 57 16.436 5.511 -6.568 1.00 1.00 C +ATOM 1828 N6 A B 57 15.119 5.704 -6.486 1.00 1.00 N +ATOM 1829 N1 A B 57 17.227 5.915 -5.560 1.00 1.00 N +ATOM 1830 C2 A B 57 18.538 5.720 -5.647 1.00 1.00 C +ATOM 1831 N3 A B 57 19.236 5.160 -6.622 1.00 1.00 N +ATOM 1832 C4 A B 57 18.415 4.766 -7.619 1.00 1.00 C +ATOM 1833 H5' A B 57 20.394 3.501 -13.184 1.00 1.00 H +ATOM 1834 H5'' A B 57 20.670 1.752 -13.057 1.00 1.00 H +ATOM 1835 H4' A B 57 21.877 2.932 -11.293 1.00 1.00 H +ATOM 1836 H3' A B 57 19.541 1.236 -10.406 1.00 1.00 H +ATOM 1837 H2' A B 57 19.804 1.926 -8.208 1.00 1.00 H +ATOM 1838 HO2' A B 57 22.153 3.193 -8.122 1.00 1.00 H +ATOM 1839 H1' A B 57 20.858 4.484 -8.679 1.00 1.00 H +ATOM 1840 H8 A B 57 17.585 3.465 -10.458 1.00 1.00 H +ATOM 1841 H61 A B 57 14.727 6.149 -5.680 1.00 1.00 H +ATOM 1842 H62 A B 57 14.516 5.405 -7.240 1.00 1.00 H +ATOM 1843 H2 A B 57 19.120 6.070 -4.794 1.00 1.00 H +ATOM 1844 P C B 58 21.334 -0.792 -9.721 1.00 1.00 P +ATOM 1845 OP1 C B 58 22.483 -1.629 -10.131 1.00 1.00 O +ATOM 1846 OP2 C B 58 19.956 -1.215 -10.061 1.00 1.00 O +ATOM 1847 O5' C B 58 21.414 -0.578 -8.125 1.00 1.00 O +ATOM 1848 C5' C B 58 22.682 -0.455 -7.469 1.00 1.00 C +ATOM 1849 C4' C B 58 22.524 -0.121 -5.985 1.00 1.00 C +ATOM 1850 O4' C B 58 21.714 1.039 -5.828 1.00 1.00 O +ATOM 1851 C3' C B 58 21.859 -1.209 -5.161 1.00 1.00 C +ATOM 1852 O3' C B 58 22.846 -2.124 -4.670 1.00 1.00 O +ATOM 1853 C2' C B 58 21.247 -0.440 -3.999 1.00 1.00 C +ATOM 1854 O2' C B 58 22.135 -0.398 -2.877 1.00 1.00 O +ATOM 1855 C1' C B 58 21.012 0.959 -4.576 1.00 1.00 C +ATOM 1856 N1 C B 58 19.589 1.264 -4.845 1.00 1.00 N +ATOM 1857 C2 C B 58 18.887 1.980 -3.888 1.00 1.00 C +ATOM 1858 O2 C B 58 19.450 2.350 -2.860 1.00 1.00 O +ATOM 1859 N3 C B 58 17.574 2.256 -4.123 1.00 1.00 N +ATOM 1860 C4 C B 58 16.977 1.848 -5.252 1.00 1.00 C +ATOM 1861 N4 C B 58 15.690 2.133 -5.451 1.00 1.00 N +ATOM 1862 C5 C B 58 17.700 1.111 -6.242 1.00 1.00 C +ATOM 1863 C6 C B 58 18.997 0.843 -6.000 1.00 1.00 C +ATOM 1864 H5' C B 58 23.256 0.335 -7.953 1.00 1.00 H +ATOM 1865 H5'' C B 58 23.222 -1.397 -7.565 1.00 1.00 H +ATOM 1866 H4' C B 58 23.506 0.087 -5.566 1.00 1.00 H +ATOM 1867 H3' C B 58 21.091 -1.723 -5.740 1.00 1.00 H +ATOM 1868 H2' C B 58 20.294 -0.889 -3.720 1.00 1.00 H +ATOM 1869 HO2' C B 58 22.338 0.524 -2.708 1.00 1.00 H +ATOM 1870 H1' C B 58 21.416 1.699 -3.890 1.00 1.00 H +ATOM 1871 H41 C B 58 15.173 2.654 -4.754 1.00 1.00 H +ATOM 1872 H42 C B 58 15.231 1.829 -6.299 1.00 1.00 H +ATOM 1873 H5 C B 58 17.218 0.781 -7.162 1.00 1.00 H +ATOM 1874 H6 C B 58 19.579 0.286 -6.733 1.00 1.00 H +ATOM 1875 P C B 59 22.440 -3.640 -4.306 1.00 1.00 P +ATOM 1876 OP1 C B 59 23.647 -4.333 -3.804 1.00 1.00 O +ATOM 1877 OP2 C B 59 21.685 -4.204 -5.447 1.00 1.00 O +ATOM 1878 O5' C B 59 21.423 -3.441 -3.072 1.00 1.00 O +ATOM 1879 C5' C B 59 21.888 -2.925 -1.823 1.00 1.00 C +ATOM 1880 C4' C B 59 20.744 -2.343 -0.993 1.00 1.00 C +ATOM 1881 O4' C B 59 20.020 -1.398 -1.769 1.00 1.00 O +ATOM 1882 C3' C B 59 19.722 -3.361 -0.511 1.00 1.00 C +ATOM 1883 O3' C B 59 20.098 -3.848 0.783 1.00 1.00 O +ATOM 1884 C2' C B 59 18.441 -2.550 -0.389 1.00 1.00 C +ATOM 1885 O2' C B 59 18.195 -2.157 0.965 1.00 1.00 O +ATOM 1886 C1' C B 59 18.669 -1.338 -1.294 1.00 1.00 C +ATOM 1887 N1 C B 59 17.758 -1.279 -2.460 1.00 1.00 N +ATOM 1888 C2 C B 59 16.651 -0.449 -2.361 1.00 1.00 C +ATOM 1889 O2 C B 59 16.461 0.201 -1.336 1.00 1.00 O +ATOM 1890 N3 C B 59 15.796 -0.384 -3.417 1.00 1.00 N +ATOM 1891 C4 C B 59 16.015 -1.104 -4.525 1.00 1.00 C +ATOM 1892 N4 C B 59 15.157 -1.016 -5.540 1.00 1.00 N +ATOM 1893 C5 C B 59 17.154 -1.962 -4.633 1.00 1.00 C +ATOM 1894 C6 C B 59 17.996 -2.020 -3.581 1.00 1.00 C +ATOM 1895 H5' C B 59 22.622 -2.142 -2.012 1.00 1.00 H +ATOM 1896 H5'' C B 59 22.362 -3.728 -1.260 1.00 1.00 H +ATOM 1897 H4' C B 59 21.163 -1.828 -0.130 1.00 1.00 H +ATOM 1898 H3' C B 59 19.608 -4.174 -1.229 1.00 1.00 H +ATOM 1899 H2' C B 59 17.608 -3.137 -0.779 1.00 1.00 H +ATOM 1900 HO2' C B 59 17.835 -1.267 0.944 1.00 1.00 H +ATOM 1901 H1' C B 59 18.550 -0.430 -0.698 1.00 1.00 H +ATOM 1902 H41 C B 59 14.352 -0.411 -5.470 1.00 1.00 H +ATOM 1903 H42 C B 59 15.312 -1.554 -6.381 1.00 1.00 H +ATOM 1904 H5 C B 59 17.336 -2.548 -5.535 1.00 1.00 H +ATOM 1905 H6 C B 59 18.874 -2.665 -3.628 1.00 1.00 H +ATOM 1906 P G B 60 19.333 -5.104 1.442 1.00 1.00 P +ATOM 1907 OP1 G B 60 20.226 -5.707 2.457 1.00 1.00 O +ATOM 1908 OP2 G B 60 18.794 -5.941 0.347 1.00 1.00 O +ATOM 1909 O5' G B 60 18.088 -4.417 2.210 1.00 1.00 O +ATOM 1910 C5' G B 60 18.298 -3.626 3.388 1.00 1.00 C +ATOM 1911 C4' G B 60 16.980 -3.145 4.000 1.00 1.00 C +ATOM 1912 O4' G B 60 16.332 -2.227 3.126 1.00 1.00 O +ATOM 1913 C3' G B 60 15.972 -4.249 4.280 1.00 1.00 C +ATOM 1914 O3' G B 60 16.174 -4.776 5.595 1.00 1.00 O +ATOM 1915 C2' G B 60 14.634 -3.534 4.211 1.00 1.00 C +ATOM 1916 O2' G B 60 14.202 -3.106 5.506 1.00 1.00 O +ATOM 1917 C1' G B 60 14.911 -2.340 3.299 1.00 1.00 C +ATOM 1918 N9 G B 60 14.311 -2.469 1.964 1.00 1.00 N +ATOM 1919 C8 G B 60 14.928 -2.759 0.774 1.00 1.00 C +ATOM 1920 N7 G B 60 14.117 -2.800 -0.245 1.00 1.00 N +ATOM 1921 C5 G B 60 12.871 -2.518 0.306 1.00 1.00 C +ATOM 1922 C6 G B 60 11.598 -2.424 -0.323 1.00 1.00 C +ATOM 1923 O6 G B 60 11.318 -2.577 -1.510 1.00 1.00 O +ATOM 1924 N1 G B 60 10.599 -2.122 0.594 1.00 1.00 N +ATOM 1925 C2 G B 60 10.796 -1.931 1.945 1.00 1.00 C +ATOM 1926 N2 G B 60 9.711 -1.648 2.665 1.00 1.00 N +ATOM 1927 N3 G B 60 11.992 -2.018 2.537 1.00 1.00 N +ATOM 1928 C4 G B 60 12.980 -2.313 1.658 1.00 1.00 C +ATOM 1929 H5' G B 60 18.904 -2.758 3.128 1.00 1.00 H +ATOM 1930 H5'' G B 60 18.834 -4.223 4.126 1.00 1.00 H +ATOM 1931 H4' G B 60 17.198 -2.629 4.932 1.00 1.00 H +ATOM 1932 H3' G B 60 16.034 -5.033 3.523 1.00 1.00 H +ATOM 1933 H2' G B 60 13.888 -4.186 3.750 1.00 1.00 H +ATOM 1934 HO2' G B 60 13.809 -2.236 5.403 1.00 1.00 H +ATOM 1935 H1' G B 60 14.533 -1.433 3.771 1.00 1.00 H +ATOM 1936 H8 G B 60 16.000 -2.938 0.689 1.00 1.00 H +ATOM 1937 H1 G B 60 9.664 -2.039 0.221 1.00 1.00 H +ATOM 1938 H21 G B 60 8.810 -1.584 2.213 1.00 1.00 H +ATOM 1939 H22 G B 60 9.791 -1.498 3.659 1.00 1.00 H +ATOM 1940 P G B 61 15.595 -6.227 5.993 1.00 1.00 P +ATOM 1941 OP1 G B 61 16.022 -6.532 7.377 1.00 1.00 O +ATOM 1942 OP2 G B 61 15.913 -7.168 4.896 1.00 1.00 O +ATOM 1943 O5' G B 61 14.002 -5.978 5.999 1.00 1.00 O +ATOM 1944 C5' G B 61 13.412 -5.067 6.932 1.00 1.00 C +ATOM 1945 C4' G B 61 11.903 -4.936 6.724 1.00 1.00 C +ATOM 1946 O4' G B 61 11.630 -4.387 5.437 1.00 1.00 O +ATOM 1947 C3' G B 61 11.139 -6.247 6.798 1.00 1.00 C +ATOM 1948 O3' G B 61 10.737 -6.490 8.151 1.00 1.00 O +ATOM 1949 C2' G B 61 9.918 -6.001 5.923 1.00 1.00 C +ATOM 1950 O2' G B 61 8.787 -5.605 6.707 1.00 1.00 O +ATOM 1951 C1' G B 61 10.362 -4.880 4.980 1.00 1.00 C +ATOM 1952 N9 G B 61 10.525 -5.307 3.577 1.00 1.00 N +ATOM 1953 C8 G B 61 11.626 -5.848 2.966 1.00 1.00 C +ATOM 1954 N7 G B 61 11.449 -6.119 1.703 1.00 1.00 N +ATOM 1955 C5 G B 61 10.136 -5.729 1.455 1.00 1.00 C +ATOM 1956 C6 G B 61 9.381 -5.785 0.251 1.00 1.00 C +ATOM 1957 O6 G B 61 9.732 -6.198 -0.853 1.00 1.00 O +ATOM 1958 N1 G B 61 8.095 -5.292 0.431 1.00 1.00 N +ATOM 1959 C2 G B 61 7.596 -4.805 1.621 1.00 1.00 C +ATOM 1960 N2 G B 61 6.335 -4.375 1.596 1.00 1.00 N +ATOM 1961 N3 G B 61 8.303 -4.752 2.754 1.00 1.00 N +ATOM 1962 C4 G B 61 9.561 -5.231 2.598 1.00 1.00 C +ATOM 1963 H5' G B 61 13.873 -4.087 6.810 1.00 1.00 H +ATOM 1964 H5'' G B 61 13.599 -5.424 7.945 1.00 1.00 H +ATOM 1965 H4' G B 61 11.505 -4.256 7.475 1.00 1.00 H +ATOM 1966 H3' G B 61 11.740 -7.070 6.406 1.00 1.00 H +ATOM 1967 H2' G B 61 9.691 -6.899 5.345 1.00 1.00 H +ATOM 1968 HO2' G B 61 8.699 -4.653 6.620 1.00 1.00 H +ATOM 1969 H1' G B 61 9.631 -4.073 5.020 1.00 1.00 H +ATOM 1970 H8 G B 61 12.563 -6.034 3.488 1.00 1.00 H +ATOM 1971 H1 G B 61 7.498 -5.300 -0.383 1.00 1.00 H +ATOM 1972 H21 G B 61 5.803 -4.416 0.739 1.00 1.00 H +ATOM 1973 H22 G B 61 5.911 -4.007 2.435 1.00 1.00 H +ATOM 1974 P G B 62 10.188 -7.935 8.603 1.00 1.00 P +ATOM 1975 OP1 G B 62 10.157 -7.978 10.082 1.00 1.00 O +ATOM 1976 OP2 G B 62 10.930 -8.971 7.850 1.00 1.00 O +ATOM 1977 O5' G B 62 8.669 -7.916 8.071 1.00 1.00 O +ATOM 1978 C5' G B 62 7.729 -6.970 8.592 1.00 1.00 C +ATOM 1979 C4' G B 62 6.442 -6.943 7.771 1.00 1.00 C +ATOM 1980 O4' G B 62 6.749 -6.660 6.410 1.00 1.00 O +ATOM 1981 C3' G B 62 5.668 -8.251 7.785 1.00 1.00 C +ATOM 1982 O3' G B 62 4.688 -8.208 8.829 1.00 1.00 O +ATOM 1983 C2' G B 62 4.981 -8.281 6.426 1.00 1.00 C +ATOM 1984 O2' G B 62 3.645 -7.773 6.508 1.00 1.00 O +ATOM 1985 C1' G B 62 5.863 -7.389 5.550 1.00 1.00 C +ATOM 1986 N9 G B 62 6.701 -8.133 4.591 1.00 1.00 N +ATOM 1987 C8 G B 62 7.912 -8.739 4.803 1.00 1.00 C +ATOM 1988 N7 G B 62 8.402 -9.325 3.746 1.00 1.00 N +ATOM 1989 C5 G B 62 7.449 -9.091 2.759 1.00 1.00 C +ATOM 1990 C6 G B 62 7.433 -9.489 1.394 1.00 1.00 C +ATOM 1991 O6 G B 62 8.277 -10.138 0.779 1.00 1.00 O +ATOM 1992 N1 G B 62 6.287 -9.047 0.748 1.00 1.00 N +ATOM 1993 C2 G B 62 5.279 -8.314 1.337 1.00 1.00 C +ATOM 1994 N2 G B 62 4.255 -7.981 0.553 1.00 1.00 N +ATOM 1995 N3 G B 62 5.290 -7.939 2.621 1.00 1.00 N +ATOM 1996 C4 G B 62 6.402 -8.361 3.268 1.00 1.00 C +ATOM 1997 H5' G B 62 8.180 -5.978 8.577 1.00 1.00 H +ATOM 1998 H5'' G B 62 7.489 -7.237 9.621 1.00 1.00 H +ATOM 1999 H4' G B 62 5.801 -6.150 8.150 1.00 1.00 H +ATOM 2000 H3' G B 62 6.340 -9.102 7.904 1.00 1.00 H +ATOM 2001 H2' G B 62 4.981 -9.302 6.035 1.00 1.00 H +ATOM 2002 HO2' G B 62 3.234 -8.172 7.280 1.00 1.00 H +ATOM 2003 H1' G B 62 5.233 -6.687 5.004 1.00 1.00 H +ATOM 2004 H8 G B 62 8.419 -8.732 5.767 1.00 1.00 H +ATOM 2005 H1 G B 62 6.205 -9.292 -0.229 1.00 1.00 H +ATOM 2006 H21 G B 62 4.249 -8.263 -0.414 1.00 1.00 H +ATOM 2007 H22 G B 62 3.486 -7.444 0.927 1.00 1.00 H +ATOM 2008 P G B 63 4.284 -9.543 9.633 1.00 1.00 P +ATOM 2009 OP1 G B 63 3.465 -9.148 10.801 1.00 1.00 O +ATOM 2010 OP2 G B 63 5.507 -10.353 9.830 1.00 1.00 O +ATOM 2011 O5' G B 63 3.332 -10.314 8.589 1.00 1.00 O +ATOM 2012 C5' G B 63 3.300 -11.743 8.564 1.00 1.00 C +ATOM 2013 C4' G B 63 2.711 -12.272 7.256 1.00 1.00 C +ATOM 2014 O4' G B 63 3.158 -11.465 6.163 1.00 1.00 O +ATOM 2015 C3' G B 63 3.090 -13.716 6.945 1.00 1.00 C +ATOM 2016 O3' G B 63 2.026 -14.582 7.348 1.00 1.00 O +ATOM 2017 C2' G B 63 3.231 -13.739 5.430 1.00 1.00 C +ATOM 2018 O2' G B 63 2.006 -14.123 4.797 1.00 1.00 O +ATOM 2019 C1' G B 63 3.607 -12.301 5.088 1.00 1.00 C +ATOM 2020 N9 G B 63 5.055 -12.079 4.944 1.00 1.00 N +ATOM 2021 C8 G B 63 5.964 -11.741 5.914 1.00 1.00 C +ATOM 2022 N7 G B 63 7.185 -11.619 5.476 1.00 1.00 N +ATOM 2023 C5 G B 63 7.083 -11.896 4.116 1.00 1.00 C +ATOM 2024 C6 G B 63 8.092 -11.917 3.114 1.00 1.00 C +ATOM 2025 O6 G B 63 9.294 -11.694 3.238 1.00 1.00 O +ATOM 2026 N1 G B 63 7.568 -12.242 1.871 1.00 1.00 N +ATOM 2027 C2 G B 63 6.240 -12.512 1.618 1.00 1.00 C +ATOM 2028 N2 G B 63 5.931 -12.804 0.355 1.00 1.00 N +ATOM 2029 N3 G B 63 5.288 -12.494 2.558 1.00 1.00 N +ATOM 2030 C4 G B 63 5.782 -12.179 3.780 1.00 1.00 C +ATOM 2031 H5' G B 63 2.691 -12.098 9.395 1.00 1.00 H +ATOM 2032 H5'' G B 63 4.314 -12.123 8.681 1.00 1.00 H +ATOM 2033 H4' G B 63 1.627 -12.201 7.310 1.00 1.00 H +ATOM 2034 H3' G B 63 4.030 -13.989 7.428 1.00 1.00 H +ATOM 2035 H2' G B 63 4.043 -14.413 5.143 1.00 1.00 H +ATOM 2036 HO2' G B 63 1.964 -15.082 4.812 1.00 1.00 H +ATOM 2037 H1' G B 63 3.107 -12.005 4.167 1.00 1.00 H +ATOM 2038 H8 G B 63 5.690 -11.586 6.957 1.00 1.00 H +ATOM 2039 H1 G B 63 8.227 -12.277 1.107 1.00 1.00 H +ATOM 2040 H21 G B 63 6.652 -12.817 -0.352 1.00 1.00 H +ATOM 2041 H22 G B 63 4.975 -13.011 0.106 1.00 1.00 H +ATOM 2042 P A B 64 2.319 -15.861 8.281 1.00 1.00 P +ATOM 2043 OP1 A B 64 1.077 -16.663 8.368 1.00 1.00 O +ATOM 2044 OP2 A B 64 2.981 -15.393 9.518 1.00 1.00 O +ATOM 2045 O5' A B 64 3.394 -16.693 7.417 1.00 1.00 O +ATOM 2046 C5' A B 64 4.599 -17.184 8.018 1.00 1.00 C +ATOM 2047 C4' A B 64 5.331 -18.145 7.083 1.00 1.00 C +ATOM 2048 O4' A B 64 4.626 -19.391 7.032 1.00 1.00 O +ATOM 2049 C3' A B 64 5.459 -17.621 5.653 1.00 1.00 C +ATOM 2050 O3' A B 64 6.817 -17.258 5.389 1.00 1.00 O +ATOM 2051 C2' A B 64 5.069 -18.800 4.777 1.00 1.00 C +ATOM 2052 O2' A B 64 6.221 -19.519 4.322 1.00 1.00 O +ATOM 2053 C1' A B 64 4.208 -19.653 5.690 1.00 1.00 C +ATOM 2054 N9 A B 64 2.768 -19.351 5.605 1.00 1.00 N +ATOM 2055 C8 A B 64 1.976 -18.718 6.526 1.00 1.00 C +ATOM 2056 N7 A B 64 0.728 -18.607 6.164 1.00 1.00 N +ATOM 2057 C5 A B 64 0.690 -19.211 4.911 1.00 1.00 C +ATOM 2058 C6 A B 64 -0.350 -19.420 3.992 1.00 1.00 C +ATOM 2059 N6 A B 64 -1.604 -19.022 4.205 1.00 1.00 N +ATOM 2060 N1 A B 64 -0.041 -20.054 2.847 1.00 1.00 N +ATOM 2061 C2 A B 64 1.210 -20.445 2.640 1.00 1.00 C +ATOM 2062 N3 A B 64 2.271 -20.307 3.423 1.00 1.00 N +ATOM 2063 C4 A B 64 1.929 -19.669 4.563 1.00 1.00 C +ATOM 2064 H5' A B 64 4.351 -17.705 8.942 1.00 1.00 H +ATOM 2065 H5'' A B 64 5.252 -16.342 8.246 1.00 1.00 H +ATOM 2066 H4' A B 64 6.326 -18.330 7.480 1.00 1.00 H +ATOM 2067 H3' A B 64 4.786 -16.777 5.491 1.00 1.00 H +ATOM 2068 H2' A B 64 4.475 -18.451 3.934 1.00 1.00 H +ATOM 2069 HO2' A B 64 6.418 -19.210 3.435 1.00 1.00 H +ATOM 2070 H1' A B 64 4.368 -20.705 5.459 1.00 1.00 H +ATOM 2071 H8 A B 64 2.354 -18.342 7.478 1.00 1.00 H +ATOM 2072 H61 A B 64 -2.315 -19.197 3.510 1.00 1.00 H +ATOM 2073 H62 A B 64 -1.843 -18.545 5.063 1.00 1.00 H +ATOM 2074 H2 A B 64 1.390 -20.953 1.692 1.00 1.00 H +ATOM 2075 P A B 65 7.156 -15.919 4.554 1.00 1.00 P +ATOM 2076 OP1 A B 65 8.627 -15.816 4.429 1.00 1.00 O +ATOM 2077 OP2 A B 65 6.387 -14.801 5.143 1.00 1.00 O +ATOM 2078 O5' A B 65 6.546 -16.238 3.096 1.00 1.00 O +ATOM 2079 C5' A B 65 7.334 -16.901 2.102 1.00 1.00 C +ATOM 2080 C4' A B 65 6.537 -18.000 1.397 1.00 1.00 C +ATOM 2081 O4' A B 65 5.415 -18.358 2.207 1.00 1.00 O +ATOM 2082 C3' A B 65 5.999 -17.600 0.025 1.00 1.00 C +ATOM 2083 O3' A B 65 6.859 -18.111 -1.000 1.00 1.00 O +ATOM 2084 C2' A B 65 4.647 -18.294 -0.052 1.00 1.00 C +ATOM 2085 O2' A B 65 4.761 -19.589 -0.652 1.00 1.00 O +ATOM 2086 C1' A B 65 4.226 -18.394 1.407 1.00 1.00 C +ATOM 2087 N9 A B 65 3.354 -17.293 1.854 1.00 1.00 N +ATOM 2088 C8 A B 65 3.609 -16.311 2.777 1.00 1.00 C +ATOM 2089 N7 A B 65 2.619 -15.475 2.943 1.00 1.00 N +ATOM 2090 C5 A B 65 1.642 -15.939 2.064 1.00 1.00 C +ATOM 2091 C6 A B 65 0.348 -15.488 1.758 1.00 1.00 C +ATOM 2092 N6 A B 65 -0.209 -14.420 2.330 1.00 1.00 N +ATOM 2093 N1 A B 65 -0.346 -16.184 0.840 1.00 1.00 N +ATOM 2094 C2 A B 65 0.214 -17.245 0.273 1.00 1.00 C +ATOM 2095 N3 A B 65 1.414 -17.763 0.475 1.00 1.00 N +ATOM 2096 C4 A B 65 2.084 -17.045 1.400 1.00 1.00 C +ATOM 2097 H5' A B 65 8.210 -17.343 2.580 1.00 1.00 H +ATOM 2098 H5'' A B 65 7.664 -16.168 1.364 1.00 1.00 H +ATOM 2099 H4' A B 65 7.169 -18.879 1.282 1.00 1.00 H +ATOM 2100 H3' A B 65 5.887 -16.517 -0.050 1.00 1.00 H +ATOM 2101 H2' A B 65 3.939 -17.670 -0.603 1.00 1.00 H +ATOM 2102 HO2' A B 65 5.692 -19.826 -0.643 1.00 1.00 H +ATOM 2103 H1' A B 65 3.712 -19.341 1.573 1.00 1.00 H +ATOM 2104 H8 A B 65 4.549 -16.235 3.323 1.00 1.00 H +ATOM 2105 H61 A B 65 -1.144 -14.139 2.074 1.00 1.00 H +ATOM 2106 H62 A B 65 0.305 -13.893 3.021 1.00 1.00 H +ATOM 2107 H2 A B 65 -0.403 -17.764 -0.462 1.00 1.00 H +ATOM 2108 P A B 66 7.401 -17.147 -2.172 1.00 1.00 P +ATOM 2109 OP1 A B 66 8.245 -17.955 -3.080 1.00 1.00 O +ATOM 2110 OP2 A B 66 7.951 -15.923 -1.548 1.00 1.00 O +ATOM 2111 O5' A B 66 6.053 -16.749 -2.961 1.00 1.00 O +ATOM 2112 C5' A B 66 5.765 -17.316 -4.244 1.00 1.00 C +ATOM 2113 C4' A B 66 4.320 -17.059 -4.664 1.00 1.00 C +ATOM 2114 O4' A B 66 3.455 -17.266 -3.543 1.00 1.00 O +ATOM 2115 C3' A B 66 4.059 -15.647 -5.182 1.00 1.00 C +ATOM 2116 O3' A B 66 4.096 -15.643 -6.613 1.00 1.00 O +ATOM 2117 C2' A B 66 2.649 -15.343 -4.703 1.00 1.00 C +ATOM 2118 O2' A B 66 1.672 -15.731 -5.676 1.00 1.00 O +ATOM 2119 C1' A B 66 2.531 -16.175 -3.436 1.00 1.00 C +ATOM 2120 N9 A B 66 2.861 -15.431 -2.210 1.00 1.00 N +ATOM 2121 C8 A B 66 4.081 -15.265 -1.607 1.00 1.00 C +ATOM 2122 N7 A B 66 4.041 -14.524 -0.533 1.00 1.00 N +ATOM 2123 C5 A B 66 2.699 -14.176 -0.418 1.00 1.00 C +ATOM 2124 C6 A B 66 1.998 -13.397 0.517 1.00 1.00 C +ATOM 2125 N6 A B 66 2.582 -12.797 1.555 1.00 1.00 N +ATOM 2126 N1 A B 66 0.674 -13.260 0.334 1.00 1.00 N +ATOM 2127 C2 A B 66 0.099 -13.854 -0.703 1.00 1.00 C +ATOM 2128 N3 A B 66 0.647 -14.606 -1.647 1.00 1.00 N +ATOM 2129 C4 A B 66 1.974 -14.726 -1.435 1.00 1.00 C +ATOM 2130 H5' A B 66 5.938 -18.392 -4.204 1.00 1.00 H +ATOM 2131 H5'' A B 66 6.434 -16.876 -4.984 1.00 1.00 H +ATOM 2132 H4' A B 66 4.048 -17.772 -5.440 1.00 1.00 H +ATOM 2133 H3' A B 66 4.775 -14.938 -4.761 1.00 1.00 H +ATOM 2134 H2' A B 66 2.557 -14.283 -4.460 1.00 1.00 H +ATOM 2135 HO2' A B 66 1.323 -16.582 -5.406 1.00 1.00 H +ATOM 2136 H1' A B 66 1.518 -16.567 -3.354 1.00 1.00 H +ATOM 2137 H8 A B 66 4.999 -15.710 -1.988 1.00 1.00 H +ATOM 2138 H61 A B 66 2.028 -12.248 2.197 1.00 1.00 H +ATOM 2139 H62 A B 66 3.580 -12.893 1.704 1.00 1.00 H +ATOM 2140 H2 A B 66 -0.975 -13.701 -0.792 1.00 1.00 H +ATOM 2141 P C B 67 4.819 -14.448 -7.414 1.00 1.00 P +ATOM 2142 OP1 C B 67 4.408 -14.528 -8.834 1.00 1.00 O +ATOM 2143 OP2 C B 67 6.256 -14.458 -7.062 1.00 1.00 O +ATOM 2144 O5' C B 67 4.151 -13.130 -6.773 1.00 1.00 O +ATOM 2145 C5' C B 67 2.758 -12.857 -6.952 1.00 1.00 C +ATOM 2146 C4' C B 67 2.277 -11.751 -6.017 1.00 1.00 C +ATOM 2147 O4' C B 67 2.563 -12.098 -4.662 1.00 1.00 O +ATOM 2148 C3' C B 67 2.925 -10.396 -6.261 1.00 1.00 C +ATOM 2149 O3' C B 67 2.144 -9.645 -7.197 1.00 1.00 O +ATOM 2150 C2' C B 67 2.879 -9.737 -4.895 1.00 1.00 C +ATOM 2151 O2' C B 67 1.675 -8.983 -4.717 1.00 1.00 O +ATOM 2152 C1' C B 67 2.942 -10.918 -3.935 1.00 1.00 C +ATOM 2153 N1 C B 67 4.283 -11.152 -3.370 1.00 1.00 N +ATOM 2154 C2 C B 67 4.640 -10.427 -2.245 1.00 1.00 C +ATOM 2155 O2 C B 67 3.851 -9.618 -1.759 1.00 1.00 O +ATOM 2156 N3 C B 67 5.873 -10.635 -1.705 1.00 1.00 N +ATOM 2157 C4 C B 67 6.720 -11.519 -2.249 1.00 1.00 C +ATOM 2158 N4 C B 67 7.920 -11.699 -1.696 1.00 1.00 N +ATOM 2159 C5 C B 67 6.357 -12.269 -3.411 1.00 1.00 C +ATOM 2160 C6 C B 67 5.135 -12.056 -3.937 1.00 1.00 C +ATOM 2161 H5' C B 67 2.189 -13.765 -6.751 1.00 1.00 H +ATOM 2162 H5'' C B 67 2.585 -12.551 -7.985 1.00 1.00 H +ATOM 2163 H4' C B 67 1.199 -11.648 -6.121 1.00 1.00 H +ATOM 2164 H3' C B 67 3.956 -10.514 -6.603 1.00 1.00 H +ATOM 2165 H2' C B 67 3.755 -9.106 -4.757 1.00 1.00 H +ATOM 2166 HO2' C B 67 1.646 -8.703 -3.800 1.00 1.00 H +ATOM 2167 H1' C B 67 2.238 -10.755 -3.122 1.00 1.00 H +ATOM 2168 H41 C B 67 8.182 -11.170 -0.873 1.00 1.00 H +ATOM 2169 H42 C B 67 8.567 -12.362 -2.098 1.00 1.00 H +ATOM 2170 H5 C B 67 7.045 -12.988 -3.857 1.00 1.00 H +ATOM 2171 H6 C B 67 4.823 -12.612 -4.821 1.00 1.00 H +ATOM 2172 P U B 68 2.801 -8.422 -8.014 1.00 1.00 P +ATOM 2173 OP1 U B 68 1.799 -7.919 -8.979 1.00 1.00 O +ATOM 2174 OP2 U B 68 4.137 -8.846 -8.490 1.00 1.00 O +ATOM 2175 O5' U B 68 3.006 -7.303 -6.871 1.00 1.00 O +ATOM 2176 C5' U B 68 1.887 -6.826 -6.118 1.00 1.00 C +ATOM 2177 C4' U B 68 2.327 -6.064 -4.868 1.00 1.00 C +ATOM 2178 O4' U B 68 3.171 -6.886 -4.067 1.00 1.00 O +ATOM 2179 C3' U B 68 3.113 -4.792 -5.145 1.00 1.00 C +ATOM 2180 O3' U B 68 2.218 -3.678 -5.250 1.00 1.00 O +ATOM 2181 C2' U B 68 3.978 -4.635 -3.906 1.00 1.00 C +ATOM 2182 O2' U B 68 3.375 -3.747 -2.963 1.00 1.00 O +ATOM 2183 C1' U B 68 4.088 -6.051 -3.343 1.00 1.00 C +ATOM 2184 N1 U B 68 5.436 -6.642 -3.476 1.00 1.00 N +ATOM 2185 C2 U B 68 6.315 -6.486 -2.421 1.00 1.00 C +ATOM 2186 O2 U B 68 6.010 -5.870 -1.401 1.00 1.00 O +ATOM 2187 N3 U B 68 7.562 -7.063 -2.579 1.00 1.00 N +ATOM 2188 C4 U B 68 8.000 -7.772 -3.685 1.00 1.00 C +ATOM 2189 O4 U B 68 9.134 -8.244 -3.717 1.00 1.00 O +ATOM 2190 C5 U B 68 7.017 -7.885 -4.739 1.00 1.00 C +ATOM 2191 C6 U B 68 5.788 -7.328 -4.607 1.00 1.00 C +ATOM 2192 H5' U B 68 1.273 -7.676 -5.818 1.00 1.00 H +ATOM 2193 H5'' U B 68 1.292 -6.163 -6.746 1.00 1.00 H +ATOM 2194 H4' U B 68 1.444 -5.810 -4.284 1.00 1.00 H +ATOM 2195 H3' U B 68 3.726 -4.899 -6.041 1.00 1.00 H +ATOM 2196 H2' U B 68 4.966 -4.281 -4.193 1.00 1.00 H +ATOM 2197 HO2' U B 68 3.048 -4.281 -2.237 1.00 1.00 H +ATOM 2198 H1' U B 68 3.804 -6.039 -2.291 1.00 1.00 H +ATOM 2199 H3 U B 68 8.215 -6.957 -1.816 1.00 1.00 H +ATOM 2200 H5 U B 68 7.267 -8.425 -5.652 1.00 1.00 H +ATOM 2201 H6 U B 68 5.066 -7.427 -5.417 1.00 1.00 H +ATOM 2202 P U B 69 2.692 -2.301 -5.945 1.00 1.00 P +ATOM 2203 OP1 U B 69 1.485 -1.568 -6.384 1.00 1.00 O +ATOM 2204 OP2 U B 69 3.757 -2.618 -6.921 1.00 1.00 O +ATOM 2205 O5' U B 69 3.358 -1.487 -4.719 1.00 1.00 O +ATOM 2206 C5' U B 69 2.572 -1.104 -3.584 1.00 1.00 C +ATOM 2207 C4' U B 69 3.448 -0.743 -2.383 1.00 1.00 C +ATOM 2208 O4' U B 69 4.238 -1.867 -1.995 1.00 1.00 O +ATOM 2209 C3' U B 69 4.427 0.390 -2.630 1.00 1.00 C +ATOM 2210 O3' U B 69 3.805 1.651 -2.337 1.00 1.00 O +ATOM 2211 C2' U B 69 5.544 0.103 -1.635 1.00 1.00 C +ATOM 2212 O2' U B 69 5.335 0.769 -0.389 1.00 1.00 O +ATOM 2213 C1' U B 69 5.488 -1.405 -1.454 1.00 1.00 C +ATOM 2214 N1 U B 69 6.574 -2.106 -2.160 1.00 1.00 N +ATOM 2215 C2 U B 69 7.710 -2.439 -1.448 1.00 1.00 C +ATOM 2216 O2 U B 69 7.841 -2.160 -0.257 1.00 1.00 O +ATOM 2217 N3 U B 69 8.697 -3.103 -2.153 1.00 1.00 N +ATOM 2218 C4 U B 69 8.645 -3.459 -3.491 1.00 1.00 C +ATOM 2219 O4 U B 69 9.584 -4.051 -4.019 1.00 1.00 O +ATOM 2220 C5 U B 69 7.421 -3.072 -4.156 1.00 1.00 C +ATOM 2221 C6 U B 69 6.441 -2.421 -3.485 1.00 1.00 C +ATOM 2222 H5' U B 69 1.918 -1.929 -3.309 1.00 1.00 H +ATOM 2223 H5'' U B 69 1.963 -0.240 -3.848 1.00 1.00 H +ATOM 2224 H4' U B 69 2.804 -0.475 -1.547 1.00 1.00 H +ATOM 2225 H3' U B 69 4.803 0.359 -3.655 1.00 1.00 H +ATOM 2226 H2' U B 69 6.504 0.374 -2.071 1.00 1.00 H +ATOM 2227 HO2' U B 69 4.424 0.610 -0.132 1.00 1.00 H +ATOM 2228 H1' U B 69 5.532 -1.645 -0.393 1.00 1.00 H +ATOM 2229 H3 U B 69 9.534 -3.353 -1.646 1.00 1.00 H +ATOM 2230 H5 U B 69 7.286 -3.305 -5.212 1.00 1.00 H +ATOM 2231 H6 U B 69 5.527 -2.144 -4.010 1.00 1.00 H +ATOM 2232 P G B 70 4.409 3.024 -2.934 1.00 1.00 P +ATOM 2233 OP1 G B 70 3.479 4.129 -2.607 1.00 1.00 O +ATOM 2234 OP2 G B 70 4.806 2.780 -4.335 1.00 1.00 O +ATOM 2235 O5' G B 70 5.747 3.213 -2.063 1.00 1.00 O +ATOM 2236 C5' G B 70 5.674 3.208 -0.640 1.00 1.00 C +ATOM 2237 C4' G B 70 7.016 2.842 -0.014 1.00 1.00 C +ATOM 2238 O4' G B 70 7.533 1.677 -0.653 1.00 1.00 O +ATOM 2239 C3' G B 70 8.101 3.897 -0.147 1.00 1.00 C +ATOM 2240 O3' G B 70 8.038 4.788 0.976 1.00 1.00 O +ATOM 2241 C2' G B 70 9.383 3.081 -0.077 1.00 1.00 C +ATOM 2242 O2' G B 70 9.914 3.063 1.252 1.00 1.00 O +ATOM 2243 C1' G B 70 8.959 1.685 -0.525 1.00 1.00 C +ATOM 2244 N9 G B 70 9.569 1.257 -1.799 1.00 1.00 N +ATOM 2245 C8 G B 70 9.029 1.213 -3.059 1.00 1.00 C +ATOM 2246 N7 G B 70 9.830 0.714 -3.960 1.00 1.00 N +ATOM 2247 C5 G B 70 10.985 0.406 -3.246 1.00 1.00 C +ATOM 2248 C6 G B 70 12.208 -0.167 -3.693 1.00 1.00 C +ATOM 2249 O6 G B 70 12.513 -0.526 -4.827 1.00 1.00 O +ATOM 2250 N1 G B 70 13.115 -0.305 -2.650 1.00 1.00 N +ATOM 2251 C2 G B 70 12.876 0.058 -1.342 1.00 1.00 C +ATOM 2252 N2 G B 70 13.871 -0.146 -0.480 1.00 1.00 N +ATOM 2253 N3 G B 70 11.729 0.594 -0.921 1.00 1.00 N +ATOM 2254 C4 G B 70 10.833 0.738 -1.924 1.00 1.00 C +ATOM 2255 H5' G B 70 4.925 2.482 -0.324 1.00 1.00 H +ATOM 2256 H5'' G B 70 5.379 4.199 -0.295 1.00 1.00 H +ATOM 2257 H4' G B 70 6.865 2.614 1.039 1.00 1.00 H +ATOM 2258 H3' G B 70 8.021 4.431 -1.095 1.00 1.00 H +ATOM 2259 H2' G B 70 10.117 3.487 -0.779 1.00 1.00 H +ATOM 2260 HO2' G B 70 9.598 3.850 1.698 1.00 1.00 H +ATOM 2261 H1' G B 70 9.237 0.967 0.245 1.00 1.00 H +ATOM 2262 H8 G B 70 8.025 1.569 -3.290 1.00 1.00 H +ATOM 2263 H1 G B 70 14.009 -0.709 -2.890 1.00 1.00 H +ATOM 2264 H21 G B 70 14.743 -0.550 -0.799 1.00 1.00 H +ATOM 2265 H22 G B 70 13.755 0.101 0.493 1.00 1.00 H +ATOM 2266 P G B 71 8.797 6.209 0.952 1.00 1.00 P +ATOM 2267 OP1 G B 71 8.115 7.112 1.905 1.00 1.00 O +ATOM 2268 OP2 G B 71 8.966 6.620 -0.460 1.00 1.00 O +ATOM 2269 O5' G B 71 10.254 5.858 1.554 1.00 1.00 O +ATOM 2270 C5' G B 71 10.455 5.732 2.969 1.00 1.00 C +ATOM 2271 C4' G B 71 11.927 5.897 3.349 1.00 1.00 C +ATOM 2272 O4' G B 71 12.620 4.655 3.184 1.00 1.00 O +ATOM 2273 C3' G B 71 12.666 6.941 2.520 1.00 1.00 C +ATOM 2274 O3' G B 71 12.713 8.180 3.236 1.00 1.00 O +ATOM 2275 C2' G B 71 14.064 6.363 2.377 1.00 1.00 C +ATOM 2276 O2' G B 71 14.917 6.779 3.448 1.00 1.00 O +ATOM 2277 C1' G B 71 13.811 4.867 2.413 1.00 1.00 C +ATOM 2278 N9 G B 71 13.579 4.273 1.087 1.00 1.00 N +ATOM 2279 C8 G B 71 12.378 3.948 0.510 1.00 1.00 C +ATOM 2280 N7 G B 71 12.486 3.442 -0.686 1.00 1.00 N +ATOM 2281 C5 G B 71 13.856 3.430 -0.923 1.00 1.00 C +ATOM 2282 C6 G B 71 14.576 2.987 -2.066 1.00 1.00 C +ATOM 2283 O6 G B 71 14.133 2.513 -3.111 1.00 1.00 O +ATOM 2284 N1 G B 71 15.943 3.146 -1.899 1.00 1.00 N +ATOM 2285 C2 G B 71 16.549 3.666 -0.775 1.00 1.00 C +ATOM 2286 N2 G B 71 17.879 3.740 -0.804 1.00 1.00 N +ATOM 2287 N3 G B 71 15.874 4.084 0.302 1.00 1.00 N +ATOM 2288 C4 G B 71 14.535 3.936 0.157 1.00 1.00 C +ATOM 2289 H5' G B 71 10.114 4.748 3.291 1.00 1.00 H +ATOM 2290 H5'' G B 71 9.870 6.496 3.481 1.00 1.00 H +ATOM 2291 H4' G B 71 11.987 6.179 4.398 1.00 1.00 H +ATOM 2292 H3' G B 71 12.194 7.065 1.542 1.00 1.00 H +ATOM 2293 H2' G B 71 14.485 6.643 1.411 1.00 1.00 H +ATOM 2294 HO2' G B 71 14.387 6.784 4.248 1.00 1.00 H +ATOM 2295 H1' G B 71 14.652 4.364 2.891 1.00 1.00 H +ATOM 2296 H8 G B 71 11.420 4.094 1.008 1.00 1.00 H +ATOM 2297 H1 G B 71 16.522 2.852 -2.672 1.00 1.00 H +ATOM 2298 H21 G B 71 18.388 3.420 -1.622 1.00 1.00 H +ATOM 2299 H22 G B 71 18.382 4.111 -0.010 1.00 1.00 H +ATOM 2300 P U B 72 12.678 9.583 2.446 1.00 1.00 P +ATOM 2301 OP1 U B 72 12.510 10.669 3.437 1.00 1.00 O +ATOM 2302 OP2 U B 72 11.723 9.456 1.323 1.00 1.00 O +ATOM 2303 O5' U B 72 14.163 9.687 1.832 1.00 1.00 O +ATOM 2304 C5' U B 72 15.296 9.851 2.692 1.00 1.00 C +ATOM 2305 C4' U B 72 16.600 9.895 1.900 1.00 1.00 C +ATOM 2306 O4' U B 72 16.858 8.623 1.312 1.00 1.00 O +ATOM 2307 C3' U B 72 16.611 10.903 0.764 1.00 1.00 C +ATOM 2308 O3' U B 72 17.077 12.172 1.241 1.00 1.00 O +ATOM 2309 C2' U B 72 17.606 10.308 -0.217 1.00 1.00 C +ATOM 2310 O2' U B 72 18.936 10.769 0.041 1.00 1.00 O +ATOM 2311 C1' U B 72 17.477 8.805 0.028 1.00 1.00 C +ATOM 2312 N1 U B 72 16.641 8.109 -0.969 1.00 1.00 N +ATOM 2313 C2 U B 72 17.270 7.578 -2.079 1.00 1.00 C +ATOM 2314 O2 U B 72 18.483 7.677 -2.253 1.00 1.00 O +ATOM 2315 N3 U B 72 16.454 6.927 -2.986 1.00 1.00 N +ATOM 2316 C4 U B 72 15.083 6.764 -2.881 1.00 1.00 C +ATOM 2317 O4 U B 72 14.455 6.165 -3.751 1.00 1.00 O +ATOM 2318 C5 U B 72 14.511 7.350 -1.689 1.00 1.00 C +ATOM 2319 C6 U B 72 15.290 7.993 -0.786 1.00 1.00 C +ATOM 2320 H5' U B 72 15.334 9.017 3.393 1.00 1.00 H +ATOM 2321 H5'' U B 72 15.187 10.781 3.250 1.00 1.00 H +ATOM 2322 H4' U B 72 17.416 10.126 2.582 1.00 1.00 H +ATOM 2323 H3' U B 72 15.620 10.987 0.311 1.00 1.00 H +ATOM 2324 H2' U B 72 17.304 10.540 -1.238 1.00 1.00 H +ATOM 2325 HO2' U B 72 19.214 11.280 -0.722 1.00 1.00 H +ATOM 2326 H1' U B 72 18.469 8.356 0.040 1.00 1.00 H +ATOM 2327 H3 U B 72 16.900 6.534 -3.802 1.00 1.00 H +ATOM 2328 H5 U B 72 13.437 7.275 -1.517 1.00 1.00 H +ATOM 2329 H6 U B 72 14.832 8.426 0.103 1.00 1.00 H +ATOM 2330 P U B 73 16.630 13.537 0.509 1.00 1.00 P +ATOM 2331 OP1 U B 73 17.084 14.674 1.340 1.00 1.00 O +ATOM 2332 OP2 U B 73 15.203 13.419 0.140 1.00 1.00 O +ATOM 2333 O5' U B 73 17.505 13.527 -0.845 1.00 1.00 O +ATOM 2334 C5' U B 73 18.918 13.757 -0.802 1.00 1.00 C +ATOM 2335 C4' U B 73 19.553 13.638 -2.187 1.00 1.00 C +ATOM 2336 O4' U B 73 19.432 12.300 -2.664 1.00 1.00 O +ATOM 2337 C3' U B 73 18.924 14.522 -3.250 1.00 1.00 C +ATOM 2338 O3' U B 73 19.548 15.811 -3.246 1.00 1.00 O +ATOM 2339 C2' U B 73 19.259 13.779 -4.532 1.00 1.00 C +ATOM 2340 O2' U B 73 20.547 14.154 -5.035 1.00 1.00 O +ATOM 2341 C1' U B 73 19.238 12.317 -4.089 1.00 1.00 C +ATOM 2342 N1 U B 73 17.963 11.626 -4.371 1.00 1.00 N +ATOM 2343 C2 U B 73 17.887 10.865 -5.521 1.00 1.00 C +ATOM 2344 O2 U B 73 18.821 10.785 -6.316 1.00 1.00 O +ATOM 2345 N3 U B 73 16.694 10.197 -5.729 1.00 1.00 N +ATOM 2346 C4 U B 73 15.586 10.226 -4.898 1.00 1.00 C +ATOM 2347 O4 U B 73 14.574 9.588 -5.180 1.00 1.00 O +ATOM 2348 C5 U B 73 15.754 11.048 -3.721 1.00 1.00 C +ATOM 2349 C6 U B 73 16.915 11.711 -3.495 1.00 1.00 C +ATOM 2350 H5' U B 73 19.378 13.026 -0.138 1.00 1.00 H +ATOM 2351 H5'' U B 73 19.104 14.757 -0.413 1.00 1.00 H +ATOM 2352 H4' U B 73 20.610 13.877 -2.110 1.00 1.00 H +ATOM 2353 H3' U B 73 17.843 14.596 -3.109 1.00 1.00 H +ATOM 2354 H2' U B 73 18.483 13.953 -5.277 1.00 1.00 H +ATOM 2355 HO2' U B 73 21.200 13.687 -4.508 1.00 1.00 H +ATOM 2356 H1' U B 73 20.052 11.776 -4.568 1.00 1.00 H +ATOM 2357 H3 U B 73 16.624 9.635 -6.566 1.00 1.00 H +ATOM 2358 H5 U B 73 14.938 11.135 -3.005 1.00 1.00 H +ATOM 2359 H6 U B 73 17.013 12.326 -2.601 1.00 1.00 H +ATOM 2360 P C B 74 18.712 17.125 -3.665 1.00 1.00 P +ATOM 2361 OP1 C B 74 19.617 18.292 -3.575 1.00 1.00 O +ATOM 2362 OP2 C B 74 17.439 17.121 -2.911 1.00 1.00 O +ATOM 2363 O5' C B 74 18.380 16.867 -5.220 1.00 1.00 O +ATOM 2364 C5' C B 74 19.369 17.106 -6.227 1.00 1.00 C +ATOM 2365 C4' C B 74 19.017 16.418 -7.545 1.00 1.00 C +ATOM 2366 O4' C B 74 18.730 15.043 -7.315 1.00 1.00 O +ATOM 2367 C3' C B 74 17.793 16.981 -8.250 1.00 1.00 C +ATOM 2368 O3' C B 74 18.168 18.081 -9.078 1.00 1.00 O +ATOM 2369 C2' C B 74 17.355 15.814 -9.117 1.00 1.00 C +ATOM 2370 O2' C B 74 18.006 15.840 -10.392 1.00 1.00 O +ATOM 2371 C1' C B 74 17.787 14.594 -8.301 1.00 1.00 C +ATOM 2372 N1 C B 74 16.672 13.935 -7.595 1.00 1.00 N +ATOM 2373 C2 C B 74 16.092 12.835 -8.207 1.00 1.00 C +ATOM 2374 O2 C B 74 16.502 12.454 -9.301 1.00 1.00 O +ATOM 2375 N3 C B 74 15.068 12.205 -7.568 1.00 1.00 N +ATOM 2376 C4 C B 74 14.630 12.637 -6.378 1.00 1.00 C +ATOM 2377 N4 C B 74 13.624 11.996 -5.778 1.00 1.00 N +ATOM 2378 C5 C B 74 15.224 13.772 -5.742 1.00 1.00 C +ATOM 2379 C6 C B 74 16.238 14.388 -6.382 1.00 1.00 C +ATOM 2380 H5' C B 74 20.330 16.731 -5.877 1.00 1.00 H +ATOM 2381 H5'' C B 74 19.447 18.179 -6.400 1.00 1.00 H +ATOM 2382 H4' C B 74 19.873 16.481 -8.214 1.00 1.00 H +ATOM 2383 H3' C B 74 17.017 17.256 -7.532 1.00 1.00 H +ATOM 2384 H2' C B 74 16.271 15.823 -9.233 1.00 1.00 H +ATOM 2385 HO2' C B 74 18.323 14.953 -10.566 1.00 1.00 H +ATOM 2386 H1' C B 74 18.272 13.872 -8.960 1.00 1.00 H +ATOM 2387 H41 C B 74 13.201 11.189 -6.236 1.00 1.00 H +ATOM 2388 H42 C B 74 13.283 12.311 -4.881 1.00 1.00 H +ATOM 2389 H5 C B 74 14.872 14.125 -4.772 1.00 1.00 H +ATOM 2390 H6 C B 74 16.714 15.257 -5.927 1.00 1.00 H +ATOM 2391 P U B 75 17.359 19.475 -9.009 1.00 1.00 P +ATOM 2392 OP1 U B 75 18.239 20.541 -9.539 1.00 1.00 O +ATOM 2393 OP2 U B 75 16.782 19.608 -7.653 1.00 1.00 O +ATOM 2394 O5' U B 75 16.145 19.276 -10.054 1.00 1.00 O +ATOM 2395 C5' U B 75 16.374 18.613 -11.303 1.00 1.00 C +ATOM 2396 C4' U B 75 15.267 17.607 -11.650 1.00 1.00 C +ATOM 2397 O4' U B 75 15.248 16.521 -10.728 1.00 1.00 O +ATOM 2398 C3' U B 75 13.857 18.167 -11.639 1.00 1.00 C +ATOM 2399 O3' U B 75 13.559 18.749 -12.910 1.00 1.00 O +ATOM 2400 C2' U B 75 12.997 16.932 -11.436 1.00 1.00 C +ATOM 2401 O2' U B 75 12.489 16.436 -12.678 1.00 1.00 O +ATOM 2402 C1' U B 75 13.936 15.932 -10.772 1.00 1.00 C +ATOM 2403 N1 U B 75 13.524 15.543 -9.407 1.00 1.00 N +ATOM 2404 C2 U B 75 12.723 14.422 -9.291 1.00 1.00 C +ATOM 2405 O2 U B 75 12.350 13.780 -10.270 1.00 1.00 O +ATOM 2406 N3 U B 75 12.362 14.064 -8.005 1.00 1.00 N +ATOM 2407 C4 U B 75 12.728 14.720 -6.841 1.00 1.00 C +ATOM 2408 O4 U B 75 12.349 14.311 -5.746 1.00 1.00 O +ATOM 2409 C5 U B 75 13.565 15.880 -7.057 1.00 1.00 C +ATOM 2410 C6 U B 75 13.931 16.250 -8.308 1.00 1.00 C +ATOM 2411 H5' U B 75 17.326 18.083 -11.249 1.00 1.00 H +ATOM 2412 H5'' U B 75 16.432 19.358 -12.094 1.00 1.00 H +ATOM 2413 H4' U B 75 15.470 17.202 -12.642 1.00 1.00 H +ATOM 2414 H3' U B 75 13.722 18.884 -10.826 1.00 1.00 H +ATOM 2415 H2' U B 75 12.185 17.164 -10.752 1.00 1.00 H +ATOM 2416 HO2' U B 75 12.529 15.479 -12.641 1.00 1.00 H +ATOM 2417 H1' U B 75 13.981 15.037 -11.394 1.00 1.00 H +ATOM 2418 H3 U B 75 11.777 13.247 -7.903 1.00 1.00 H +ATOM 2419 H5 U B 75 13.905 16.464 -6.202 1.00 1.00 H +ATOM 2420 H6 U B 75 14.561 17.130 -8.443 1.00 1.00 H +ATOM 2421 P U B 76 12.375 19.832 -13.071 1.00 1.00 P +ATOM 2422 OP1 U B 76 12.464 20.413 -14.429 1.00 1.00 O +ATOM 2423 OP2 U B 76 12.393 20.721 -11.888 1.00 1.00 O +ATOM 2424 O5' U B 76 11.039 18.929 -13.002 1.00 1.00 O +ATOM 2425 C5' U B 76 10.597 18.198 -14.151 1.00 1.00 C +ATOM 2426 C4' U B 76 9.263 17.492 -13.906 1.00 1.00 C +ATOM 2427 O4' U B 76 9.420 16.496 -12.902 1.00 1.00 O +ATOM 2428 C3' U B 76 8.144 18.405 -13.429 1.00 1.00 C +ATOM 2429 O3' U B 76 7.395 18.888 -14.545 1.00 1.00 O +ATOM 2430 C2' U B 76 7.262 17.494 -12.590 1.00 1.00 C +ATOM 2431 O2' U B 76 6.155 16.998 -13.352 1.00 1.00 O +ATOM 2432 C1' U B 76 8.195 16.364 -12.165 1.00 1.00 C +ATOM 2433 N1 U B 76 8.537 16.389 -10.728 1.00 1.00 N +ATOM 2434 C2 U B 76 7.800 15.589 -9.875 1.00 1.00 C +ATOM 2435 O2 U B 76 6.877 14.884 -10.275 1.00 1.00 O +ATOM 2436 N3 U B 76 8.164 15.627 -8.541 1.00 1.00 N +ATOM 2437 C4 U B 76 9.186 16.385 -7.995 1.00 1.00 C +ATOM 2438 O4 U B 76 9.422 16.341 -6.790 1.00 1.00 O +ATOM 2439 C5 U B 76 9.902 17.190 -8.960 1.00 1.00 C +ATOM 2440 C6 U B 76 9.565 17.168 -10.271 1.00 1.00 C +ATOM 2441 H5' U B 76 11.349 17.452 -14.407 1.00 1.00 H +ATOM 2442 H5'' U B 76 10.483 18.887 -14.988 1.00 1.00 H +ATOM 2443 H4' U B 76 8.949 17.003 -14.827 1.00 1.00 H +ATOM 2444 H3' U B 76 8.540 19.227 -12.829 1.00 1.00 H +ATOM 2445 H2' U B 76 6.909 18.033 -11.709 1.00 1.00 H +ATOM 2446 HO2' U B 76 5.900 17.687 -13.969 1.00 1.00 H +ATOM 2447 H1' U B 76 7.733 15.406 -12.410 1.00 1.00 H +ATOM 2448 H3 U B 76 7.634 15.047 -7.907 1.00 1.00 H +ATOM 2449 H5 U B 76 10.725 17.822 -8.626 1.00 1.00 H +ATOM 2450 H6 U B 76 10.122 17.784 -10.976 1.00 1.00 H +ATOM 2451 P C B 77 6.266 20.013 -14.327 1.00 1.00 P +ATOM 2452 OP1 C B 77 5.724 20.391 -15.651 1.00 1.00 O +ATOM 2453 OP2 C B 77 6.816 21.054 -13.430 1.00 1.00 O +ATOM 2454 O5' C B 77 5.126 19.204 -13.524 1.00 1.00 O +ATOM 2455 C5' C B 77 4.619 19.696 -12.279 1.00 1.00 C +ATOM 2456 C4' C B 77 3.704 18.678 -11.598 1.00 1.00 C +ATOM 2457 O4' C B 77 4.484 17.667 -10.961 1.00 1.00 O +ATOM 2458 C3' C B 77 2.805 19.274 -10.527 1.00 1.00 C +ATOM 2459 O3' C B 77 1.544 19.627 -11.105 1.00 1.00 O +ATOM 2460 C2' C B 77 2.616 18.142 -9.528 1.00 1.00 C +ATOM 2461 O2' C B 77 1.389 17.441 -9.763 1.00 1.00 O +ATOM 2462 C1' C B 77 3.826 17.236 -9.759 1.00 1.00 C +ATOM 2463 N1 C B 77 4.821 17.280 -8.672 1.00 1.00 N +ATOM 2464 C2 C B 77 4.587 16.502 -7.549 1.00 1.00 C +ATOM 2465 O2 C B 77 3.570 15.815 -7.478 1.00 1.00 O +ATOM 2466 N3 C B 77 5.506 16.523 -6.546 1.00 1.00 N +ATOM 2467 C4 C B 77 6.610 17.278 -6.639 1.00 1.00 C +ATOM 2468 N4 C B 77 7.490 17.274 -5.639 1.00 1.00 N +ATOM 2469 C5 C B 77 6.854 18.084 -7.796 1.00 1.00 C +ATOM 2470 C6 C B 77 5.939 18.056 -8.783 1.00 1.00 C +ATOM 2471 H5' C B 77 4.059 20.613 -12.459 1.00 1.00 H +ATOM 2472 H5'' C B 77 5.459 19.916 -11.617 1.00 1.00 H +ATOM 2473 H4' C B 77 3.082 18.205 -12.356 1.00 1.00 H +ATOM 2474 H3' C B 77 3.280 20.136 -10.055 1.00 1.00 H +ATOM 2475 H2' C B 77 2.641 18.539 -8.510 1.00 1.00 H +ATOM 2476 HO2' C B 77 0.673 18.057 -9.598 1.00 1.00 H +ATOM 2477 H1' C B 77 3.484 16.210 -9.886 1.00 1.00 H +ATOM 2478 H41 C B 77 7.326 16.710 -4.824 1.00 1.00 H +ATOM 2479 H42 C B 77 8.325 17.840 -5.700 1.00 1.00 H +ATOM 2480 H5 C B 77 7.750 18.701 -7.874 1.00 1.00 H +ATOM 2481 H6 C B 77 6.093 18.657 -9.680 1.00 1.00 H +ATOM 2482 P C B 78 0.583 20.696 -10.383 1.00 1.00 P +ATOM 2483 OP1 C B 78 -0.554 20.980 -11.286 1.00 1.00 O +ATOM 2484 OP2 C B 78 1.420 21.808 -9.877 1.00 1.00 O +ATOM 2485 O5' C B 78 0.027 19.868 -9.120 1.00 1.00 O +ATOM 2486 C5' C B 78 -0.264 20.532 -7.889 1.00 1.00 C +ATOM 2487 C4' C B 78 -0.882 19.580 -6.870 1.00 1.00 C +ATOM 2488 O4' C B 78 0.010 18.493 -6.618 1.00 1.00 O +ATOM 2489 C3' C B 78 -1.186 20.230 -5.530 1.00 1.00 C +ATOM 2490 O3' C B 78 -2.552 20.658 -5.513 1.00 1.00 O +ATOM 2491 C2' C B 78 -0.975 19.113 -4.520 1.00 1.00 C +ATOM 2492 O2' C B 78 -2.206 18.445 -4.217 1.00 1.00 O +ATOM 2493 C1' C B 78 0.008 18.176 -5.219 1.00 1.00 C +ATOM 2494 N1 C B 78 1.399 18.295 -4.740 1.00 1.00 N +ATOM 2495 C2 C B 78 1.706 17.726 -3.516 1.00 1.00 C +ATOM 2496 O2 C B 78 0.835 17.149 -2.870 1.00 1.00 O +ATOM 2497 N3 C B 78 2.986 17.825 -3.061 1.00 1.00 N +ATOM 2498 C4 C B 78 3.924 18.458 -3.778 1.00 1.00 C +ATOM 2499 N4 C B 78 5.166 18.538 -3.304 1.00 1.00 N +ATOM 2500 C5 C B 78 3.610 19.049 -5.043 1.00 1.00 C +ATOM 2501 C6 C B 78 2.342 18.944 -5.484 1.00 1.00 C +ATOM 2502 H5' C B 78 -0.962 21.348 -8.081 1.00 1.00 H +ATOM 2503 H5'' C B 78 0.659 20.943 -7.479 1.00 1.00 H +ATOM 2504 H4' C B 78 -1.806 19.179 -7.282 1.00 1.00 H +ATOM 2505 H3' C B 78 -0.507 21.063 -5.337 1.00 1.00 H +ATOM 2506 H2' C B 78 -0.521 19.516 -3.611 1.00 1.00 H +ATOM 2507 HO2' C B 78 -2.769 18.523 -4.990 1.00 1.00 H +ATOM 2508 H1' C B 78 -0.324 17.147 -5.086 1.00 1.00 H +ATOM 2509 H41 C B 78 5.394 18.125 -2.413 1.00 1.00 H +ATOM 2510 H42 C B 78 5.880 19.014 -3.837 1.00 1.00 H +ATOM 2511 H5 C B 78 4.370 19.565 -5.629 1.00 1.00 H +ATOM 2512 H6 C B 78 2.066 19.383 -6.444 1.00 1.00 H +ATOM 2513 P U B 79 -2.976 22.016 -4.763 1.00 1.00 P +ATOM 2514 OP1 U B 79 -4.179 22.559 -5.434 1.00 1.00 O +ATOM 2515 OP2 U B 79 -1.769 22.861 -4.613 1.00 1.00 O +ATOM 2516 O5' U B 79 -3.407 21.490 -3.306 1.00 1.00 O +ATOM 2517 C5' U B 79 -3.151 22.279 -2.143 1.00 1.00 C +ATOM 2518 C4' U B 79 -3.241 21.442 -0.872 1.00 1.00 C +ATOM 2519 O4' U B 79 -2.179 20.489 -0.851 1.00 1.00 O +ATOM 2520 C3' U B 79 -3.145 22.256 0.410 1.00 1.00 C +ATOM 2521 O3' U B 79 -4.461 22.542 0.896 1.00 1.00 O +ATOM 2522 C2' U B 79 -2.431 21.334 1.382 1.00 1.00 C +ATOM 2523 O2' U B 79 -3.364 20.632 2.211 1.00 1.00 O +ATOM 2524 C1' U B 79 -1.660 20.376 0.479 1.00 1.00 C +ATOM 2525 N1 U B 79 -0.214 20.650 0.423 1.00 1.00 N +ATOM 2526 C2 U B 79 0.493 20.516 1.602 1.00 1.00 C +ATOM 2527 O2 U B 79 -0.051 20.200 2.658 1.00 1.00 O +ATOM 2528 N3 U B 79 1.852 20.762 1.526 1.00 1.00 N +ATOM 2529 C4 U B 79 2.554 21.124 0.389 1.00 1.00 C +ATOM 2530 O4 U B 79 3.767 21.316 0.437 1.00 1.00 O +ATOM 2531 C5 U B 79 1.736 21.241 -0.796 1.00 1.00 C +ATOM 2532 C6 U B 79 0.402 21.005 -0.746 1.00 1.00 C +ATOM 2533 H5' U B 79 -3.881 23.086 -2.091 1.00 1.00 H +ATOM 2534 H5'' U B 79 -2.151 22.707 -2.218 1.00 1.00 H +ATOM 2535 H4' U B 79 -4.185 20.902 -0.875 1.00 1.00 H +ATOM 2536 H3' U B 79 -2.573 23.172 0.249 1.00 1.00 H +ATOM 2537 H2' U B 79 -1.731 21.910 1.993 1.00 1.00 H +ATOM 2538 HO2' U B 79 -3.043 19.731 2.302 1.00 1.00 H +ATOM 2539 H1' U B 79 -1.809 19.358 0.834 1.00 1.00 H +ATOM 2540 H3 U B 79 2.382 20.667 2.381 1.00 1.00 H +ATOM 2541 H5 U B 79 2.197 21.522 -1.743 1.00 1.00 H +ATOM 2542 H6 U B 79 -0.192 21.101 -1.655 1.00 1.00 H +ATOM 2543 P A B 80 -4.740 23.856 1.783 1.00 1.00 P +ATOM 2544 OP1 A B 80 -6.191 23.925 2.066 1.00 1.00 O +ATOM 2545 OP2 A B 80 -4.059 25.001 1.139 1.00 1.00 O +ATOM 2546 O5' A B 80 -3.973 23.526 3.160 1.00 1.00 O +ATOM 2547 C5' A B 80 -4.315 22.365 3.926 1.00 1.00 C +ATOM 2548 C4' A B 80 -3.521 22.299 5.228 1.00 1.00 C +ATOM 2549 O4' A B 80 -2.129 22.156 4.929 1.00 1.00 O +ATOM 2550 C3' A B 80 -3.677 23.535 6.106 1.00 1.00 C +ATOM 2551 O3' A B 80 -3.711 23.144 7.483 1.00 1.00 O +ATOM 2552 C2' A B 80 -2.424 24.351 5.836 1.00 1.00 C +ATOM 2553 O2' A B 80 -1.974 25.021 7.018 1.00 1.00 O +ATOM 2554 C1' A B 80 -1.408 23.315 5.366 1.00 1.00 C +ATOM 2555 N9 A B 80 -0.570 23.770 4.240 1.00 1.00 N +ATOM 2556 C8 A B 80 -0.958 24.387 3.077 1.00 1.00 C +ATOM 2557 N7 A B 80 0.032 24.672 2.276 1.00 1.00 N +ATOM 2558 C5 A B 80 1.156 24.213 2.957 1.00 1.00 C +ATOM 2559 C6 A B 80 2.524 24.216 2.642 1.00 1.00 C +ATOM 2560 N6 A B 80 3.010 24.720 1.507 1.00 1.00 N +ATOM 2561 N1 A B 80 3.365 23.680 3.542 1.00 1.00 N +ATOM 2562 C2 A B 80 2.876 23.178 4.669 1.00 1.00 C +ATOM 2563 N3 A B 80 1.617 23.115 5.078 1.00 1.00 N +ATOM 2564 C4 A B 80 0.798 23.661 4.154 1.00 1.00 C +ATOM 2565 H5' A B 80 -4.107 21.474 3.336 1.00 1.00 H +ATOM 2566 H5'' A B 80 -5.379 22.396 4.160 1.00 1.00 H +ATOM 2567 H4' A B 80 -3.843 21.425 5.792 1.00 1.00 H +ATOM 2568 H3' A B 80 -4.573 24.095 5.833 1.00 1.00 H +ATOM 2569 H2' A B 80 -2.615 25.071 5.036 1.00 1.00 H +ATOM 2570 HO2' A B 80 -2.444 25.856 7.070 1.00 1.00 H +ATOM 2571 H1' A B 80 -0.763 23.043 6.200 1.00 1.00 H +ATOM 2572 H8 A B 80 -1.996 24.618 2.843 1.00 1.00 H +ATOM 2573 H61 A B 80 4.005 24.698 1.329 1.00 1.00 H +ATOM 2574 H62 A B 80 2.384 25.125 0.825 1.00 1.00 H +ATOM 2575 H2 A B 80 3.613 22.758 5.354 1.00 1.00 H +ATOM 2576 P A B 81 -5.020 22.435 8.099 1.00 1.00 P +ATOM 2577 OP1 A B 81 -4.665 21.044 8.458 1.00 1.00 O +ATOM 2578 OP2 A B 81 -6.157 22.694 7.187 1.00 1.00 O +ATOM 2579 O5' A B 81 -5.267 23.259 9.460 1.00 1.00 O +ATOM 2580 C5' A B 81 -4.172 23.615 10.307 1.00 1.00 C +ATOM 2581 C4' A B 81 -3.693 22.426 11.134 1.00 1.00 C +ATOM 2582 O4' A B 81 -3.136 21.435 10.269 1.00 1.00 O +ATOM 2583 C3' A B 81 -2.633 22.783 12.168 1.00 1.00 C +ATOM 2584 O3' A B 81 -3.250 22.922 13.453 1.00 1.00 O +ATOM 2585 C2' A B 81 -1.696 21.588 12.170 1.00 1.00 C +ATOM 2586 O2' A B 81 -2.063 20.636 13.175 1.00 1.00 O +ATOM 2587 C1' A B 81 -1.862 21.011 10.769 1.00 1.00 C +ATOM 2588 N9 A B 81 -0.842 21.468 9.809 1.00 1.00 N +ATOM 2589 C8 A B 81 -0.995 22.275 8.713 1.00 1.00 C +ATOM 2590 N7 A B 81 0.112 22.494 8.059 1.00 1.00 N +ATOM 2591 C5 A B 81 1.068 21.780 8.775 1.00 1.00 C +ATOM 2592 C6 A B 81 2.450 21.602 8.599 1.00 1.00 C +ATOM 2593 N6 A B 81 3.135 22.159 7.600 1.00 1.00 N +ATOM 2594 N1 A B 81 3.092 20.831 9.493 1.00 1.00 N +ATOM 2595 C2 A B 81 2.403 20.281 10.486 1.00 1.00 C +ATOM 2596 N3 A B 81 1.110 20.372 10.758 1.00 1.00 N +ATOM 2597 C4 A B 81 0.495 21.151 9.844 1.00 1.00 C +ATOM 2598 H5' A B 81 -4.486 24.412 10.980 1.00 1.00 H +ATOM 2599 H5'' A B 81 -3.349 23.976 9.690 1.00 1.00 H +ATOM 2600 H4' A B 81 -4.548 21.989 11.645 1.00 1.00 H +ATOM 2601 H3' A B 81 -2.103 23.693 11.882 1.00 1.00 H +ATOM 2602 H2' A B 81 -0.666 21.924 12.314 1.00 1.00 H +ATOM 2603 HO2' A B 81 -1.335 20.583 13.796 1.00 1.00 H +ATOM 2604 H1' A B 81 -1.838 19.924 10.823 1.00 1.00 H +ATOM 2605 H8 A B 81 -1.956 22.694 8.412 1.00 1.00 H +ATOM 2606 H61 A B 81 4.130 21.999 7.518 1.00 1.00 H +ATOM 2607 H62 A B 81 2.659 22.741 6.922 1.00 1.00 H +ATOM 2608 H2 A B 81 2.986 19.666 11.174 1.00 1.00 H +ATOM 2609 P G B 82 -2.634 23.922 14.555 1.00 1.00 P +ATOM 2610 OP1 G B 82 -3.703 24.258 15.522 1.00 1.00 O +ATOM 2611 OP2 G B 82 -1.913 25.003 13.847 1.00 1.00 O +ATOM 2612 O5' G B 82 -1.549 22.997 15.303 1.00 1.00 O +ATOM 2613 C5' G B 82 -0.341 23.566 15.815 1.00 1.00 C +ATOM 2614 C4' G B 82 0.840 22.615 15.647 1.00 1.00 C +ATOM 2615 O4' G B 82 0.803 22.037 14.339 1.00 1.00 O +ATOM 2616 C3' G B 82 2.200 23.286 15.820 1.00 1.00 C +ATOM 2617 O3' G B 82 2.723 22.991 17.121 1.00 1.00 O +ATOM 2618 C2' G B 82 3.071 22.637 14.757 1.00 1.00 C +ATOM 2619 O2' G B 82 3.783 21.511 15.281 1.00 1.00 O +ATOM 2620 C1' G B 82 2.067 22.213 13.694 1.00 1.00 C +ATOM 2621 N9 G B 82 1.882 23.202 12.617 1.00 1.00 N +ATOM 2622 C8 G B 82 0.821 24.041 12.397 1.00 1.00 C +ATOM 2623 N7 G B 82 0.959 24.805 11.350 1.00 1.00 N +ATOM 2624 C5 G B 82 2.201 24.447 10.835 1.00 1.00 C +ATOM 2625 C6 G B 82 2.890 24.942 9.693 1.00 1.00 C +ATOM 2626 O6 G B 82 2.532 25.810 8.900 1.00 1.00 O +ATOM 2627 N1 G B 82 4.117 24.310 9.526 1.00 1.00 N +ATOM 2628 C2 G B 82 4.618 23.327 10.352 1.00 1.00 C +ATOM 2629 N2 G B 82 5.816 22.840 10.028 1.00 1.00 N +ATOM 2630 N3 G B 82 3.972 22.861 11.425 1.00 1.00 N +ATOM 2631 C4 G B 82 2.774 23.466 11.604 1.00 1.00 C +ATOM 2632 H5' G B 82 -0.472 23.785 16.874 1.00 1.00 H +ATOM 2633 H5'' G B 82 -0.130 24.493 15.283 1.00 1.00 H +ATOM 2634 H4' G B 82 0.751 21.813 16.377 1.00 1.00 H +ATOM 2635 H3' G B 82 2.124 24.362 15.659 1.00 1.00 H +ATOM 2636 H2' G B 82 3.763 23.373 14.342 1.00 1.00 H +ATOM 2637 HO2' G B 82 4.716 21.660 15.111 1.00 1.00 H +ATOM 2638 H1' G B 82 2.385 21.266 13.259 1.00 1.00 H +ATOM 2639 H8 G B 82 -0.059 24.068 13.040 1.00 1.00 H +ATOM 2640 H1 G B 82 4.666 24.610 8.734 1.00 1.00 H +ATOM 2641 H21 G B 82 6.303 23.193 9.217 1.00 1.00 H +ATOM 2642 H22 G B 82 6.237 22.118 10.595 1.00 1.00 H +ATOM 2643 P U B 83 3.182 24.181 18.107 1.00 1.00 P +ATOM 2644 OP1 U B 83 3.502 23.586 19.425 1.00 1.00 O +ATOM 2645 OP2 U B 83 2.185 25.269 18.012 1.00 1.00 O +ATOM 2646 O5' U B 83 4.558 24.698 17.445 1.00 1.00 O +ATOM 2647 C5' U B 83 5.817 24.161 17.865 1.00 1.00 C +ATOM 2648 C4' U B 83 6.944 24.546 16.908 1.00 1.00 C +ATOM 2649 O4' U B 83 6.590 24.184 15.574 1.00 1.00 O +ATOM 2650 C3' U B 83 7.268 26.033 16.891 1.00 1.00 C +ATOM 2651 O3' U B 83 8.319 26.314 17.825 1.00 1.00 O +ATOM 2652 C2' U B 83 7.758 26.267 15.472 1.00 1.00 C +ATOM 2653 O2' U B 83 9.178 26.105 15.372 1.00 1.00 O +ATOM 2654 C1' U B 83 7.021 25.207 14.664 1.00 1.00 C +ATOM 2655 N1 U B 83 5.822 25.719 13.972 1.00 1.00 N +ATOM 2656 C2 U B 83 5.960 26.123 12.658 1.00 1.00 C +ATOM 2657 O2 U B 83 7.037 26.072 12.066 1.00 1.00 O +ATOM 2658 N3 U B 83 4.813 26.591 12.043 1.00 1.00 N +ATOM 2659 C4 U B 83 3.558 26.689 12.621 1.00 1.00 C +ATOM 2660 O4 U B 83 2.604 27.121 11.977 1.00 1.00 O +ATOM 2661 C5 U B 83 3.507 26.245 13.996 1.00 1.00 C +ATOM 2662 C6 U B 83 4.619 25.782 14.619 1.00 1.00 C +ATOM 2663 H5' U B 83 5.743 23.073 17.907 1.00 1.00 H +ATOM 2664 H5'' U B 83 6.051 24.540 18.859 1.00 1.00 H +ATOM 2665 H4' U B 83 7.840 23.995 17.184 1.00 1.00 H +ATOM 2666 H3' U B 83 6.377 26.629 17.100 1.00 1.00 H +ATOM 2667 H2' U B 83 7.459 27.258 15.134 1.00 1.00 H +ATOM 2668 HO2' U B 83 9.439 26.424 14.505 1.00 1.00 H +ATOM 2669 H1' U B 83 7.702 24.773 13.932 1.00 1.00 H +ATOM 2670 H3 U B 83 4.898 26.889 11.081 1.00 1.00 H +ATOM 2671 H5 U B 83 2.563 26.283 14.539 1.00 1.00 H +ATOM 2672 H6 U B 83 4.552 25.453 15.656 1.00 1.00 H +ATOM 2673 P C B 84 8.311 27.680 18.681 1.00 1.00 P +ATOM 2674 OP1 C B 84 9.179 27.486 19.864 1.00 1.00 O +ATOM 2675 OP2 C B 84 6.906 28.108 18.859 1.00 1.00 O +ATOM 2676 O5' C B 84 9.038 28.728 17.694 1.00 1.00 O +ATOM 2677 C5' C B 84 10.448 28.656 17.460 1.00 1.00 C +ATOM 2678 C4' C B 84 10.832 29.356 16.161 1.00 1.00 C +ATOM 2679 O4' C B 84 10.022 28.856 15.100 1.00 1.00 O +ATOM 2680 C3' C B 84 10.652 30.869 16.176 1.00 1.00 C +ATOM 2681 O3' C B 84 11.882 31.503 16.550 1.00 1.00 O +ATOM 2682 C2' C B 84 10.327 31.186 14.726 1.00 1.00 C +ATOM 2683 O2' C B 84 11.515 31.401 13.957 1.00 1.00 O +ATOM 2684 C1' C B 84 9.586 29.940 14.269 1.00 1.00 C +ATOM 2685 N1 C B 84 8.116 30.036 14.393 1.00 1.00 N +ATOM 2686 C2 C B 84 7.401 30.389 13.259 1.00 1.00 C +ATOM 2687 O2 C B 84 7.993 30.640 12.212 1.00 1.00 O +ATOM 2688 N3 C B 84 6.043 30.448 13.344 1.00 1.00 N +ATOM 2689 C4 C B 84 5.413 30.173 14.494 1.00 1.00 C +ATOM 2690 N4 C B 84 4.083 30.240 14.544 1.00 1.00 N +ATOM 2691 C5 C B 84 6.147 29.810 15.667 1.00 1.00 C +ATOM 2692 C6 C B 84 7.490 29.754 15.573 1.00 1.00 C +ATOM 2693 H5' C B 84 10.748 27.610 17.401 1.00 1.00 H +ATOM 2694 H5'' C B 84 10.973 29.132 18.289 1.00 1.00 H +ATOM 2695 H4' C B 84 11.870 29.128 15.931 1.00 1.00 H +ATOM 2696 H3' C B 84 9.831 31.162 16.835 1.00 1.00 H +ATOM 2697 H2' C B 84 9.667 32.047 14.667 1.00 1.00 H +ATOM 2698 HO2' C B 84 11.255 31.863 13.157 1.00 1.00 H +ATOM 2699 H1' C B 84 9.844 29.725 13.235 1.00 1.00 H +ATOM 2700 H41 C B 84 3.554 30.500 13.713 1.00 1.00 H +ATOM 2701 H42 C B 84 3.598 30.036 15.406 1.00 1.00 H +ATOM 2702 H5 C B 84 5.638 29.585 16.605 1.00 1.00 H +ATOM 2703 H6 C B 84 8.082 29.481 16.447 1.00 1.00 H +ATOM 2704 P C B 85 11.884 32.971 17.218 1.00 1.00 P +ATOM 2705 OP1 C B 85 13.290 33.384 17.424 1.00 1.00 O +ATOM 2706 OP2 C B 85 10.943 32.962 18.361 1.00 1.00 O +ATOM 2707 O5' C B 85 11.256 33.891 16.055 1.00 1.00 O +ATOM 2708 C5' C B 85 11.912 34.005 14.792 1.00 1.00 C +ATOM 2709 C4' C B 85 10.956 34.475 13.699 1.00 1.00 C +ATOM 2710 O4' C B 85 9.783 33.665 13.711 1.00 1.00 O +ATOM 2711 C3' C B 85 10.472 35.911 13.843 1.00 1.00 C +ATOM 2712 O3' C B 85 11.347 36.794 13.134 1.00 1.00 O +ATOM 2713 C2' C B 85 9.116 35.899 13.159 1.00 1.00 C +ATOM 2714 O2' C B 85 9.209 36.365 11.808 1.00 1.00 O +ATOM 2715 C1' C B 85 8.683 34.440 13.219 1.00 1.00 C +ATOM 2716 N1 C B 85 7.513 34.213 14.091 1.00 1.00 N +ATOM 2717 C2 C B 85 6.268 34.447 13.531 1.00 1.00 C +ATOM 2718 O2 C B 85 6.178 34.834 12.367 1.00 1.00 O +ATOM 2719 N3 C B 85 5.164 34.241 14.302 1.00 1.00 N +ATOM 2720 C4 C B 85 5.280 33.820 15.569 1.00 1.00 C +ATOM 2721 N4 C B 85 4.179 33.628 16.299 1.00 1.00 N +ATOM 2722 C5 C B 85 6.564 33.577 16.150 1.00 1.00 C +ATOM 2723 C6 C B 85 7.649 33.785 15.379 1.00 1.00 C +ATOM 2724 H5' C B 85 12.318 33.032 14.514 1.00 1.00 H +ATOM 2725 H5'' C B 85 12.731 34.719 14.879 1.00 1.00 H +ATOM 2726 H4' C B 85 11.441 34.361 12.732 1.00 1.00 H +ATOM 2727 H3' C B 85 10.381 36.192 14.893 1.00 1.00 H +ATOM 2728 H2' C B 85 8.415 36.504 13.727 1.00 1.00 H +ATOM 2729 HO2' C B 85 9.274 35.592 11.244 1.00 1.00 H +ATOM 2730 H1' C B 85 8.440 34.105 12.210 1.00 1.00 H +ATOM 2731 H41 C B 85 3.268 33.800 15.891 1.00 1.00 H +ATOM 2732 H42 C B 85 4.255 33.312 17.255 1.00 1.00 H +ATOM 2733 H5 C B 85 6.661 33.235 17.181 1.00 1.00 H +ATOM 2734 H6 C B 85 8.643 33.609 15.788 1.00 1.00 H +ATOM 2735 P U B 86 11.254 38.390 13.342 1.00 1.00 P +ATOM 2736 OP1 U B 86 12.293 39.026 12.502 1.00 1.00 O +ATOM 2737 OP2 U B 86 11.214 38.665 14.796 1.00 1.00 O +ATOM 2738 O5' U B 86 9.810 38.757 12.717 1.00 1.00 O +ATOM 2739 C5' U B 86 9.625 38.839 11.297 1.00 1.00 C +ATOM 2740 C4' U B 86 8.242 39.385 10.927 1.00 1.00 C +ATOM 2741 O4' U B 86 7.237 38.497 11.404 1.00 1.00 O +ATOM 2742 C3' U B 86 7.935 40.757 11.508 1.00 1.00 C +ATOM 2743 O3' U B 86 8.298 41.799 10.596 1.00 1.00 O +ATOM 2744 C2' U B 86 6.427 40.722 11.734 1.00 1.00 C +ATOM 2745 O2' U B 86 5.720 41.310 10.638 1.00 1.00 O +ATOM 2746 C1' U B 86 6.104 39.243 11.870 1.00 1.00 C +ATOM 2747 N1 U B 86 5.852 38.836 13.263 1.00 1.00 N +ATOM 2748 C2 U B 86 4.543 38.748 13.695 1.00 1.00 C +ATOM 2749 O2 U B 86 3.593 38.994 12.956 1.00 1.00 O +ATOM 2750 N3 U B 86 4.362 38.370 15.014 1.00 1.00 N +ATOM 2751 C4 U B 86 5.363 38.077 15.924 1.00 1.00 C +ATOM 2752 O4 U B 86 5.086 37.749 17.075 1.00 1.00 O +ATOM 2753 C5 U B 86 6.701 38.194 15.386 1.00 1.00 C +ATOM 2754 C6 U B 86 6.902 38.563 14.097 1.00 1.00 C +ATOM 2755 H5' U B 86 9.738 37.845 10.867 1.00 1.00 H +ATOM 2756 H5'' U B 86 10.386 39.497 10.876 1.00 1.00 H +ATOM 2757 H4' U B 86 8.164 39.436 9.845 1.00 1.00 H +ATOM 2758 H3' U B 86 8.453 40.883 12.463 1.00 1.00 H +ATOM 2759 HO3' U B 86 7.486 42.229 10.316 1.00 1.00 H +ATOM 2760 H2' U B 86 6.182 41.231 12.668 1.00 1.00 H +ATOM 2761 HO2' U B 86 4.851 40.905 10.613 1.00 1.00 H +ATOM 2762 H1' U B 86 5.237 39.008 11.258 1.00 1.00 H +ATOM 2763 H3 U B 86 3.410 38.303 15.344 1.00 1.00 H +ATOM 2764 H5 U B 86 7.557 37.987 16.026 1.00 1.00 H +ATOM 2765 H6 U B 86 7.921 38.644 13.718 1.00 1.00 H +TER 2766 U B 86 +ENDMDL +MASTER 91 0 0 0 0 0 0 6 1836 2 0 8 +END diff --git a/tests/rna/test_graphs.py b/tests/rna/test_graphs.py index 2d0a3a54..7ef82542 100644 --- a/tests/rna/test_graphs.py +++ b/tests/rna/test_graphs.py @@ -1,3 +1,6 @@ +from pathlib import Path + +import networkx as nx import pytest from hypothesis import given from hypothesis.strategies import text @@ -10,7 +13,7 @@ from graphein.rna.graphs import ( RNA_BASES, SUPPORTED_DOTBRACKET_NOTATION, - construct_rna_graph, + construct_graph, ) TEST_SEQUENCE = "UUGGAGUACACAACCUGUACACUCUUUC" @@ -18,7 +21,7 @@ def test_construct_rna_graph(): - g = construct_rna_graph( + g = construct_graph( dotbracket=TEST_DOTBRACKET, sequence=TEST_SEQUENCE, edge_construction_funcs=[ @@ -27,7 +30,7 @@ def test_construct_rna_graph(): ], ) - h = construct_rna_graph( + h = construct_graph( dotbracket=TEST_DOTBRACKET, sequence=TEST_SEQUENCE, edge_construction_funcs=[add_all_dotbracket_edges], @@ -56,3 +59,58 @@ def test_construct_rna_graph(): assert phosphodiesters == len(TEST_SEQUENCE) - 1 assert bp == TEST_DOTBRACKET.count("(") + + +def test_pdb_rna_graph(): + g = construct_graph(pdb_code="2jyf") + assert isinstance(g, nx.Graph) + + for n, d in g.nodes(data=True): + assert isinstance(n, str) + assert "coords" in d.keys() + assert "chain_id" in d.keys() + assert "residue_name" in d.keys() + assert "residue_number" in d.keys() + assert "atom_type" in d.keys() + assert "b_factor" in d.keys() + + for _, _, d in g.edges(data=True): + assert "kind" in d.keys() + assert "bond_length" in d.keys() + + assert "name" in g.graph.keys() + assert "pdb_code" in g.graph.keys() + assert "pdb_path" in g.graph.keys() + assert "chain_ids" in g.graph.keys() + assert "pdb_df" in g.graph.keys() + assert "raw_pdb_df" in g.graph.keys() + assert "coords" in g.graph.keys() + + +def test_construct_graph(): + """Example-based test that graph construction works correctly. + Uses 4hhb PDB file as an example test case. + """ + file_path = Path(__file__).parent / "test_data/2jyf.pdb" + g = construct_graph(pdb_path=str(file_path)) + + for n, d in g.nodes(data=True): + assert isinstance(n, str) + assert "coords" in d.keys() + assert "chain_id" in d.keys() + assert "residue_name" in d.keys() + assert "residue_number" in d.keys() + assert "atom_type" in d.keys() + assert "b_factor" in d.keys() + + for _, _, d in g.edges(data=True): + assert "kind" in d.keys() + assert "bond_length" in d.keys() + + assert "name" in g.graph.keys() + assert "pdb_code" in g.graph.keys() + assert "pdb_path" in g.graph.keys() + assert "chain_ids" in g.graph.keys() + assert "pdb_df" in g.graph.keys() + assert "raw_pdb_df" in g.graph.keys() + assert "coords" in g.graph.keys() diff --git a/tests/rna/test_nussinov.py b/tests/rna/test_nussinov.py new file mode 100644 index 00000000..67c83034 --- /dev/null +++ b/tests/rna/test_nussinov.py @@ -0,0 +1,10 @@ +from graphein.rna.nussinov import nussinov + +TEST_SEQUENCE = "UUGGAGUACACAACCUGUACACUCUUUC" + + +def test_nussinov(): + # nussinov algo does not guarantee that the dot-bracket notation is correct. + # There are several other ways of computing this. + target_dot_bracket = nussinov(TEST_SEQUENCE) + assert len(TEST_SEQUENCE) == len(target_dot_bracket) diff --git a/tests/rna/test_subgraphs.py b/tests/rna/test_subgraphs.py new file mode 100644 index 00000000..13ae21e1 --- /dev/null +++ b/tests/rna/test_subgraphs.py @@ -0,0 +1,301 @@ +"""Tests for graphein.rna.subgraphs""" +# Graphein +# Author: Arian Jamasb +# License: MIT +# Project Website: https://github.com/a-r-j/graphein +# Code Repository: https://github.com/a-r-j/graphein + +from pathlib import Path + +import networkx as nx +import numpy as np + +from graphein.rna.graphs import construct_graph +from graphein.rna.subgraphs import ( + extract_k_hop_subgraph, + extract_subgraph_by_bond_type, + extract_subgraph_by_sequence_position, + extract_subgraph_from_atom_types, + extract_subgraph_from_chains, + extract_subgraph_from_node_list, + extract_subgraph_from_point, + extract_subgraph_from_residue_types, +) + + +def test_node_list_subgraphing(): + """Tests subgraph extraction from a list of nodes.""" + file_path = Path(__file__).parent / "test_data/2jyf.pdb" + NODE_LIST = [ + "A:A:4:121:N3", + "A:A:4:122:C4", + "A:U:5:134:P", + "A:U:5:135:OP1", + ] + + G = construct_graph(pdb_path=str(file_path)) + + g = extract_subgraph_from_node_list(G, NODE_LIST, filter_dataframe=True) + + # Check we get back a graph and it contains the correct nodes + assert isinstance(g, nx.Graph) + assert len(g) == len(NODE_LIST) + for n in g.nodes(): + assert n in NODE_LIST + assert ( + g.graph["pdb_df"]["node_id"] + .str.contains("|".join(NODE_LIST), case=True) + .all() + ) + + # Check the list of nodes is the same as the list of nodes in the original graph + returned_node_list = extract_subgraph_from_node_list( + G, NODE_LIST, return_node_list=True + ) + assert all(elem in NODE_LIST for elem in returned_node_list) + + # Check there is no overlap when we inverse the selection + g = extract_subgraph_from_node_list( + G, NODE_LIST, inverse=True, filter_dataframe=True + ) + assert len(g) == len(G) - len(NODE_LIST) + for n in g.nodes(): + assert n not in NODE_LIST + + assert not ( + g.graph["pdb_df"]["node_id"] + .str.contains("|".join(NODE_LIST), case=True) + .any() + ) + + returned_node_list = extract_subgraph_from_node_list( + G, NODE_LIST, inverse=True, return_node_list=True + ) + + assert all(elem not in NODE_LIST for elem in returned_node_list) + + +def test_extract_subgraph_from_atom_types(): + """Tests subgraph extraction from a list of allowed atom types""" + file_path = Path(__file__).parent / "test_data/2jyf.pdb" + G = construct_graph(pdb_path=str(file_path)) + + ATOM_TYPES = ["P"] + g = extract_subgraph_from_atom_types(G, ATOM_TYPES, filter_dataframe=True) + assert isinstance(g, nx.Graph) + assert len(g) == 84 + + +def test_extract_subgraph_from_residue_types(): + """Tests subgraph extraction from a list of nodes.""" + file_path = Path(__file__).parent / "test_data/2jyf.pdb" + RESIDUE_TYPES = ["A", "G"] + + A_COUNT = 484 # TODO + G_COUNT = 592 # TODO + + G = construct_graph(pdb_path=str(file_path)) + + g = extract_subgraph_from_residue_types( + G, RESIDUE_TYPES, filter_dataframe=True + ) + + # Check we get back a graph and it contains the correct nodes + assert isinstance(g, nx.Graph) + assert len(g) == A_COUNT + G_COUNT + for n, d in g.nodes(data=True): + assert d["residue_name"] in RESIDUE_TYPES + assert ( + g.graph["pdb_df"]["residue_name"] + .str.contains("|".join(RESIDUE_TYPES), case=True) + .all() + ) + + assert ( + len([n for n, d in g.nodes(data=True) if d["residue_name"] == "A"]) + == A_COUNT + ) + assert ( + len([n for n, d in g.nodes(data=True) if d["residue_name"] == "G"]) + == G_COUNT + ) + + # Check the list of nodes is the same as the list of nodes in the original graph + returned_node_list = extract_subgraph_from_node_list( + G, RESIDUE_TYPES, return_node_list=True + ) + assert all(elem in RESIDUE_TYPES for elem in returned_node_list) + + # Check there is no overlap when we inverse the selection + g = extract_subgraph_from_residue_types( + G, RESIDUE_TYPES, inverse=True, filter_dataframe=True + ) + + # assert len(g) == (len(G) - GLYCINES - ALANINES - SERINES) + for n in g.nodes(): + assert n not in RESIDUE_TYPES + + assert not ( + g.graph["pdb_df"]["residue_name"] + .str.contains("|".join(RESIDUE_TYPES), case=True) + .any() + ) + + returned_node_list = extract_subgraph_from_residue_types( + G, RESIDUE_TYPES, inverse=True, return_node_list=True + ) + + assert all(elem not in RESIDUE_TYPES for elem in returned_node_list) + + +def test_extract_subgraph_from_point(): + """Tests subgraph extraction from a spherical selection.""" + file_path = Path(__file__).parent / "test_data/2jyf.pdb" + G = construct_graph(pdb_path=str(file_path)) + + POINT = np.array([0.0, 0.0, 0.0]) + RADIUS = 10 + s_g = extract_subgraph_from_point(G, POINT, RADIUS, filter_dataframe=True) + + # Check all nodes are within the sphere + for n, d in s_g.nodes(data=True): + assert np.linalg.norm(d["coords"] - POINT) < RADIUS + + # Check we have extracted all the nodes + for n, d in G.nodes(data=True): + if np.linalg.norm(d["coords"] - POINT) < RADIUS: + assert n in s_g.nodes() + + s_g = extract_subgraph_from_point( + G, POINT, RADIUS, filter_dataframe=True, inverse=True + ) + + # Check all nodes are not within the sphere + for n, d in s_g.nodes(data=True): + assert np.linalg.norm(d["coords"] - POINT) > RADIUS + + # Check we have extracted all the nodes + for n, d in G.nodes(data=True): + if np.linalg.norm(d["coords"] - POINT) > RADIUS: + assert n in s_g.nodes() + + +def test_extract_subgraph_from_chains(): + """Tests subgraph extraction from chains.""" + file_path = Path(__file__).parent / "test_data/2jyf.pdb" + G = construct_graph(pdb_path=str(file_path)) + + CHAINS = ["A", "C"] + s_g = extract_subgraph_from_chains(G, CHAINS, filter_dataframe=True) + + # Test we only selected the correct chains + for n, d in s_g.nodes(data=True): + assert d["chain_id"] in CHAINS + + # Test we have extracted all the nodes + for n, d in G.nodes(data=True): + if d["chain_id"] in CHAINS: + assert n in s_g.nodes() + + # Test the dataframe is correct + assert s_g.graph["pdb_df"]["chain_id"].isin(CHAINS).all() + + s_g = extract_subgraph_from_chains( + G, CHAINS, filter_dataframe=True, inverse=True + ) + + # Test we only selected the correct chains + for n, d in s_g.nodes(data=True): + assert d["chain_id"] not in CHAINS + + # Test we have extracted all the nodes + for n, d in G.nodes(data=True): + if d["chain_id"] in CHAINS: + assert n not in s_g.nodes() + + +# @pytest.mark.skip(reason="TODO") +def test_extract_subgraph_from_sequence_position(): + """Tests subgraph extraction from sequence position.""" + file_path = Path(__file__).parent / "test_data/2jyf.pdb" + G = construct_graph(pdb_path=str(file_path)) + + SEQ_POS = list(range(1, 50, 2)) + + s_g = extract_subgraph_by_sequence_position( + G, + SEQ_POS, + filter_dataframe=True, + ) + # Test we only selected the correct chains + for n, d in s_g.nodes(data=True): + assert d["residue_number"] in SEQ_POS + + # Test we have extracted all the nodes + for n, d in G.nodes(data=True): + if d["residue_number"] in SEQ_POS: + assert n in s_g.nodes() + + # Test the dataframe is correct + assert s_g.graph["pdb_df"]["residue_number"].isin(SEQ_POS).all() + + s_g = extract_subgraph_by_sequence_position( + G, SEQ_POS, filter_dataframe=True, inverse=True + ) + # Test we only selected the correct chains + for n, d in s_g.nodes(data=True): + assert d["residue_number"] not in SEQ_POS + + # Test we have extracted all the nodes + for n, d in G.nodes(data=True): + if d["residue_number"] in SEQ_POS: + assert n not in s_g.nodes() + + +def test_extract_subgraph_from_bond_type(): + """Tests subgraph extraction from bond type""" + file_path = Path(__file__).parent / "test_data/2jyf.pdb" + G = construct_graph(pdb_path=str(file_path)) + + BOND_TYPES = ["covalent"] + + s_g = extract_subgraph_by_bond_type(G, BOND_TYPES, filter_dataframe=True) + + for u, v, d in G.edges(data=True): + if d["kind"] in BOND_TYPES: + assert u in s_g.nodes() + assert v in s_g.nodes() + assert (u, v) in s_g.edges() + + for u, v, d in s_g.edges(data=True): + for bond in list(d["kind"]): + assert bond in BOND_TYPES + + s_g = extract_subgraph_by_bond_type( + G, BOND_TYPES, filter_dataframe=True, inverse=True + ) + + for u, v, d in G.edges(data=True): + if d["kind"] in BOND_TYPES: + assert (u, v) not in s_g.edges() + + for u, v, d in s_g.edges(data=True): + for bond in list(d["kind"]): + assert bond not in BOND_TYPES + + +def test_extract_k_hop_subgraph(): + """Tests k-hop subgraph extraction.""" + file_path = Path(__file__).parent / "test_data/2jyf.pdb" + G = construct_graph(pdb_path=str(file_path)) + + CENTRAL_NODE = "A:A:6:181:N6" + K = 1 + s_g = extract_k_hop_subgraph(G, CENTRAL_NODE, K, filter_dataframe=True) + + for n in s_g.nodes(): + if n != CENTRAL_NODE: + assert n in list(G.neighbors(CENTRAL_NODE)) + + for n in list(G.neighbors(CENTRAL_NODE)): + assert n in s_g.nodes() diff --git a/tests/utils/test_protein_graph_config.yml b/tests/utils/test_protein_graph_config.yml index c4c1ffe3..00ae4b40 100644 --- a/tests/utils/test_protein_graph_config.yml +++ b/tests/utils/test_protein_graph_config.yml @@ -1,17 +1,17 @@ !ProteinGraphConfig - granularity: "CA" - keep_hets: False - insertions: False - verbose: False - node_metadata_functions: - - !func:graphein.protein.features.nodes.amino_acid.meiler_embedding - - !func:graphein.protein.features.nodes.amino_acid.expasy_protein_scale - edge_construction_functions: - - !func:graphein.protein.edges.distance.add_peptide_bonds - - !func:graphein.protein.edges.distance.add_distance_threshold - long_interaction_threshold: 5 - threshold: 10. - get_contacts_config: !GetContactsConfig - contacts_dir: "../examples/contacts/" - pdb_dir: "../examples/contacts/" - dssp_config: !DSSPConfig \ No newline at end of file +granularity: "CA" +keep_hets: [] +insertions: False +verbose: False +node_metadata_functions: + - !func:graphein.protein.features.nodes.amino_acid.meiler_embedding + - !func:graphein.protein.features.nodes.amino_acid.expasy_protein_scale +edge_construction_functions: + - !func:graphein.protein.edges.distance.add_peptide_bonds + - !func:graphein.protein.edges.distance.add_distance_threshold + long_interaction_threshold: 5 + threshold: 10. +get_contacts_config: !GetContactsConfig + contacts_dir: "../examples/contacts/" + pdb_dir: "../examples/contacts/" +dssp_config: !DSSPConfig diff --git a/tests/utils/test_yml_parser.py b/tests/utils/test_yml_parser.py index 02d40f63..ace44d29 100644 --- a/tests/utils/test_yml_parser.py +++ b/tests/utils/test_yml_parser.py @@ -21,7 +21,7 @@ protein_graph_config = { "granularity": "CA", - "keep_hets": False, + "keep_hets": [], "insertions": False, "verbose": False, "node_metadata_functions": [meiler_embedding, expasy_protein_scale],