diff --git a/packages/components/CHANGELOG.md b/packages/components/CHANGELOG.md
index 0676541a232413..365f70fdc67fd1 100644
--- a/packages/components/CHANGELOG.md
+++ b/packages/components/CHANGELOG.md
@@ -30,6 +30,7 @@
 ### Internal
 
 -   `Tooltip`: Refactor tests to `@testing-library/react` ([#43061](https://github.com/WordPress/gutenberg/pull/43061)).
+-   Clean up unused and duplicate `COLORS` values ([#43445](https://github.com/WordPress/gutenberg/pull/43445)).
 -   Update `floating-ui` to the latest version ([#43206](https://github.com/WordPress/gutenberg/pull/43206)).
 -   `DateTimePicker`, `TimePicker`, `DatePicker`: Switch from `moment` to `date-fns` ([#43005](https://github.com/WordPress/gutenberg/pull/43005)).
 -   `DatePicker`: Switch from `react-dates` to `use-lilius` ([#43005](https://github.com/WordPress/gutenberg/pull/43005)).
diff --git a/packages/components/src/alignment-matrix-control/styles/alignment-matrix-control-styles.js b/packages/components/src/alignment-matrix-control/styles/alignment-matrix-control-styles.js
index 1e35a4195460c6..88ae648252aae2 100644
--- a/packages/components/src/alignment-matrix-control/styles/alignment-matrix-control-styles.js
+++ b/packages/components/src/alignment-matrix-control/styles/alignment-matrix-control-styles.js
@@ -45,9 +45,7 @@ export const Row = styled.div`
 const pointActive = ( { isActive } ) => {
 	const boxShadow = isActive ? `0 0 0 2px ${ COLORS.gray[ 900 ] }` : null;
 	const pointColor = isActive ? COLORS.gray[ 900 ] : COLORS.lightGray[ 800 ];
-	const pointColorHover = isActive
-		? COLORS.gray[ 900 ]
-		: COLORS.blue.medium.focus;
+	const pointColorHover = isActive ? COLORS.gray[ 900 ] : COLORS.ui.theme;
 
 	return css`
 		box-shadow: ${ boxShadow };
diff --git a/packages/components/src/angle-picker-control/styles/angle-picker-control-styles.js b/packages/components/src/angle-picker-control/styles/angle-picker-control-styles.js
index 7deb0c4645b474..1a7ed713d72f18 100644
--- a/packages/components/src/angle-picker-control/styles/angle-picker-control-styles.js
+++ b/packages/components/src/angle-picker-control/styles/angle-picker-control-styles.js
@@ -45,9 +45,9 @@ export const CircleIndicatorWrapper = styled.div`
 `;
 
 export const CircleIndicator = styled.div`
-	background: ${ COLORS.admin.theme };
+	background: ${ COLORS.ui.theme };
 	border-radius: 50%;
-	border: ${ INNER_CIRCLE_SIZE }px solid ${ COLORS.admin.theme };
+	border: ${ INNER_CIRCLE_SIZE }px solid ${ COLORS.ui.theme };
 	bottom: 0;
 	box-sizing: border-box;
 	display: block;
diff --git a/packages/components/src/base-control/styles/base-control-styles.ts b/packages/components/src/base-control/styles/base-control-styles.ts
index ca8c45159ecc8f..abd2f3affc45ae 100644
--- a/packages/components/src/base-control/styles/base-control-styles.ts
+++ b/packages/components/src/base-control/styles/base-control-styles.ts
@@ -64,7 +64,7 @@ export const StyledHelp = styled.p`
 	margin-bottom: 0;
 	font-size: ${ font( 'helpText.fontSize' ) };
 	font-style: normal;
-	color: ${ COLORS.mediumGray.text };
+	color: ${ COLORS.gray[ 700 ] };
 
 	${ deprecatedMarginHelp }
 `;
diff --git a/packages/components/src/base-field/styles.js b/packages/components/src/base-field/styles.js
index e054dc2c6ed498..30bd93cd41aa4b 100644
--- a/packages/components/src/base-field/styles.js
+++ b/packages/components/src/base-field/styles.js
@@ -35,7 +35,7 @@ export const BaseField = css`
 
 	&:focus,
 	&[data-focused='true'] {
-		border-color: ${ COLORS.admin.theme };
+		border-color: ${ COLORS.ui.theme };
 		box-shadow: ${ CONFIG.controlBoxShadowFocus };
 	}
 `;
diff --git a/packages/components/src/base-field/test/__snapshots__/index.js.snap b/packages/components/src/base-field/test/__snapshots__/index.js.snap
index 189db5c48bf126..bf844bf643de68 100644
--- a/packages/components/src/base-field/test/__snapshots__/index.js.snap
+++ b/packages/components/src/base-field/test/__snapshots__/index.js.snap
@@ -129,8 +129,8 @@ exports[`base field should render correctly 1`] = `
 
 .emotion-0:focus,
 .emotion-0[data-focused='true'] {
-  border-color: var( --wp-admin-theme-color, #00669b);
-  box-shadow: 0 0 0 0.5px var( --wp-admin-theme-color, #00669b);
+  border-color: var( --wp-admin-theme-color, #007cba);
+  box-shadow: 0 0 0 0.5px var( --wp-admin-theme-color, #007cba);
 }
 
 <div
diff --git a/packages/components/src/box-control/styles/box-control-visualizer-styles.js b/packages/components/src/box-control/styles/box-control-visualizer-styles.js
index 527daac217bab4..2a5c4fc8ec4702 100644
--- a/packages/components/src/box-control/styles/box-control-visualizer-styles.js
+++ b/packages/components/src/box-control/styles/box-control-visualizer-styles.js
@@ -31,7 +31,6 @@ export const Container = styled.div`
 
 export const Side = styled.div`
 	box-sizing: border-box;
-	background: ${ COLORS.blue.wordpress[ 700 ] };
 	background: ${ COLORS.ui.theme };
 	filter: brightness( 1 );
 	opacity: 0;
diff --git a/packages/components/src/focal-point-picker/styles/focal-point-style.js b/packages/components/src/focal-point-picker/styles/focal-point-style.js
index 80f724f64ece84..89e248c986962c 100644
--- a/packages/components/src/focal-point-picker/styles/focal-point-style.js
+++ b/packages/components/src/focal-point-picker/styles/focal-point-style.js
@@ -42,6 +42,5 @@ export const PointerIconPathOutline = styled( Path )`
 `;
 
 export const PointerIconPathFill = styled( Path )`
-	fill: ${ COLORS.blue.wordpress[ 700 ] };
 	fill: ${ COLORS.ui.theme };
 `;
diff --git a/packages/components/src/item-group/styles.ts b/packages/components/src/item-group/styles.ts
index cb2758752e6562..35bd50120033fc 100644
--- a/packages/components/src/item-group/styles.ts
+++ b/packages/components/src/item-group/styles.ts
@@ -16,13 +16,13 @@ export const unstyledButton = css`
 	text-align: left;
 
 	&:hover {
-		color: ${ COLORS.admin.theme };
+		color: ${ COLORS.ui.theme };
 	}
 
 	&:focus {
 		background-color: transparent;
-		color: ${ COLORS.admin.theme };
-		border-color: ${ COLORS.admin.theme };
+		color: ${ COLORS.ui.theme };
+		border-color: ${ COLORS.ui.theme };
 		outline: 3px solid transparent;
 	}
 `;
diff --git a/packages/components/src/palette-edit/styles.js b/packages/components/src/palette-edit/styles.js
index cca12006b91d64..e524f153f88482 100644
--- a/packages/components/src/palette-edit/styles.js
+++ b/packages/components/src/palette-edit/styles.js
@@ -29,7 +29,7 @@ export const IndicatorStyled = styled( CircularOptionPicker.Option )`
 export const NameInputControl = styled( InputControl )`
 	${ InputControlContainer } {
 		background: ${ COLORS.gray[ 100 ] };
-		border-radius: ${ CONFIG.controlBorderRadius }};
+		border-radius: ${ CONFIG.controlBorderRadius };
 		${ Input }${ Input }${ Input }${ Input } {
 			height: ${ space( 8 ) };
 		}
@@ -58,7 +58,7 @@ export const PaletteItem = styled( View )`
 		border-top-color: transparent;
 	}
 	&.is-selected {
-		border-color: ${ COLORS.blue.wordpress[ 700 ] };
+		border-color: ${ COLORS.ui.theme };
 	}
 `;
 
@@ -69,7 +69,7 @@ export const NameContainer = styled.div`
 	white-space: nowrap;
 	overflow: hidden;
 	${ PaletteItem }:hover & {
-		color: var( --wp-admin-theme-color, ${ COLORS.blue.wordpress[ 700 ] } );
+		color: ${ COLORS.ui.theme };
 	}
 `;
 
@@ -95,8 +95,9 @@ export const PaletteHStackHeader = styled( HStack )`
 export const PaletteEditStyles = styled( View )`
 	&&& {
 		.components-button.has-icon {
-		min-width: 0;
-		padding: 0;
+			min-width: 0;
+			padding: 0;
+		}
 	}
 `;
 
diff --git a/packages/components/src/range-control/styles/range-control-styles.ts b/packages/components/src/range-control/styles/range-control-styles.ts
index b54cbcbc7412f3..c746bc9c72a6fb 100644
--- a/packages/components/src/range-control/styles/range-control-styles.ts
+++ b/packages/components/src/range-control/styles/range-control-styles.ts
@@ -48,7 +48,6 @@ const wrapperMargin = ( { marks, __nextHasNoMarginBottom }: WrapperProps ) => {
 };
 
 export const Wrapper = styled.div< WrapperProps >`
-	color: ${ COLORS.blue.medium.focus };
 	display: block;
 	flex: 1;
 	position: relative;
diff --git a/packages/components/src/text/styles.js b/packages/components/src/text/styles.js
index 4d7990cd3f3f06..171e34fab9f46f 100644
--- a/packages/components/src/text/styles.js
+++ b/packages/components/src/text/styles.js
@@ -27,7 +27,7 @@ export const destructive = css`
 `;
 
 export const muted = css`
-	color: ${ COLORS.mediumGray.text };
+	color: ${ COLORS.gray[ 700 ] };
 `;
 
 export const highlighterText = css`
diff --git a/packages/components/src/text/test/index.tsx b/packages/components/src/text/test/index.tsx
index c5dc40f0ae8958..2b4f4c4d6ae5df 100644
--- a/packages/components/src/text/test/index.tsx
+++ b/packages/components/src/text/test/index.tsx
@@ -53,7 +53,7 @@ describe( 'Text', () => {
 			<Text variant="muted">Lorem ipsum.</Text>
 		);
 		expect( container.firstChild ).toHaveStyle( {
-			color: COLORS.mediumGray.text,
+			color: COLORS.gray[ 700 ],
 		} );
 	} );
 
diff --git a/packages/components/src/toggle-group-control/test/__snapshots__/index.tsx.snap b/packages/components/src/toggle-group-control/test/__snapshots__/index.tsx.snap
index 91fa420c5d078f..2ce03affa087fd 100644
--- a/packages/components/src/toggle-group-control/test/__snapshots__/index.tsx.snap
+++ b/packages/components/src/toggle-group-control/test/__snapshots__/index.tsx.snap
@@ -55,8 +55,8 @@ exports[`ToggleGroupControl should render correctly with icons 1`] = `
 }
 
 .emotion-6:focus-within {
-  border-color: var( --wp-admin-theme-color-darker-10, #007cba);
-  box-shadow: 0 0 0 0.5px var( --wp-admin-theme-color, #00669b);
+  border-color: var( --wp-admin-theme-color-darker-10, #006ba1);
+  box-shadow: 0 0 0 0.5px var( --wp-admin-theme-color, #007cba);
   outline: none;
   z-index: 1;
 }
@@ -326,8 +326,8 @@ exports[`ToggleGroupControl should render correctly with text options 1`] = `
 }
 
 .emotion-6:focus-within {
-  border-color: var( --wp-admin-theme-color-darker-10, #007cba);
-  box-shadow: 0 0 0 0.5px var( --wp-admin-theme-color, #00669b);
+  border-color: var( --wp-admin-theme-color-darker-10, #006ba1);
+  box-shadow: 0 0 0 0.5px var( --wp-admin-theme-color, #007cba);
   outline: none;
   z-index: 1;
 }
diff --git a/packages/components/src/utils/colors-values.js b/packages/components/src/utils/colors-values.js
index e2be5b7d25bd06..00bfe83d65c3c1 100644
--- a/packages/components/src/utils/colors-values.js
+++ b/packages/components/src/utils/colors-values.js
@@ -1,180 +1,85 @@
-/**
- * External dependencies
- */
-import { merge } from 'lodash';
-
 /**
  * Internal dependencies
  */
 import { rgba } from './colors';
 
-const BASE = {
-	black: '#000',
-	white: '#fff',
-};
+const white = '#fff';
 
-const G2 = {
-	blue: {
-		medium: {
-			focus: '#007cba',
-			focusDark: '#fff',
-		},
-	},
-	gray: {
-		900: '#1e1e1e',
-		700: '#757575', // Meets 4.6:1 text contrast against white.
-		600: '#949494', // Meets 3:1 UI or large text contrast against white.
-		400: '#ccc',
-		300: '#ddd', // Used for most borders.
-		200: '#e0e0e0', // Used sparingly for light borders.
-		100: '#f0f0f0', // Used for light gray backgrounds.
-	},
-	mediumGray: {
-		text: '#757575',
-	},
-	lightGray: {
-		ui: '#949494',
-		secondary: '#ccc',
-		tertiary: '#e7e8e9',
-	},
+// Matches the grays in @wordpress/base-styles
+const GRAY = {
+	900: '#1e1e1e',
+	800: '#2f2f2f',
+	/** Meets 4.6:1 text contrast against white. */
+	700: '#757575',
+	/** Meets 3:1 UI or large text contrast against white. */
+	600: '#949494',
+	400: '#ccc',
+	/** Used for most borders. */
+	300: '#ddd',
+	/** Used sparingly for light borders. */
+	200: '#e0e0e0',
+	/** Used for light gray backgrounds. */
+	100: '#f0f0f0',
 };
 
 const DARK_GRAY = {
-	900: '#191e23',
-	800: '#23282d',
-	700: '#32373c',
-	600: '#40464d',
 	500: '#555d66', // Use this most of the time for dark items.
-	400: '#606a73',
 	300: '#6c7781', // Lightest gray that can be used for AA text contrast.
-	200: '#7e8993',
 	150: '#8d96a0', // Lightest gray that can be used for AA non-text contrast.
-	100: '#8f98a1',
-	placeholder: rgba( G2.gray[ 900 ], 0.62 ),
-};
-
-const DARK_OPACITY = {
-	900: rgba( '#000510', 0.9 ),
-	800: rgba( '#00000a', 0.85 ),
-	700: rgba( '#06060b', 0.8 ),
-	600: rgba( '#000913', 0.75 ),
-	500: rgba( '#0a1829', 0.7 ),
-	400: rgba( '#0a1829', 0.65 ),
-	300: rgba( '#0e1c2e', 0.62 ),
-	200: rgba( '#162435', 0.55 ),
-	100: rgba( '#223443', 0.5 ),
-	backgroundFill: rgba( DARK_GRAY[ 700 ], 0.7 ),
-};
-
-const DARK_OPACITY_LIGHT = {
-	900: rgba( '#304455', 0.45 ),
-	800: rgba( '#425863', 0.4 ),
-	700: rgba( '#667886', 0.35 ),
-	600: rgba( '#7b86a2', 0.3 ),
-	500: rgba( '#9197a2', 0.25 ),
-	400: rgba( '#95959c', 0.2 ),
-	300: rgba( '#829493', 0.15 ),
-	200: rgba( '#8b8b96', 0.1 ),
-	100: rgba( '#747474', 0.05 ),
 };
 
 const LIGHT_GRAY = {
-	900: '#a2aab2',
 	800: '#b5bcc2',
-	700: '#ccd0d4',
 	600: '#d7dade',
-	500: '#e2e4e7', // Good for "grayed" items and borders.
 	400: '#e8eaeb', // Good for "readonly" input fields and special text selection.
 	300: '#edeff0',
 	200: '#f3f4f5',
-	100: '#f8f9f9',
-	placeholder: rgba( BASE.white, 0.65 ),
-};
-
-const LIGHT_OPACITY_LIGHT = {
-	900: rgba( BASE.white, 0.5 ),
-	800: rgba( BASE.white, 0.45 ),
-	700: rgba( BASE.white, 0.4 ),
-	600: rgba( BASE.white, 0.35 ),
-	500: rgba( BASE.white, 0.3 ),
-	400: rgba( BASE.white, 0.25 ),
-	300: rgba( BASE.white, 0.2 ),
-	200: rgba( BASE.white, 0.15 ),
-	100: rgba( BASE.white, 0.1 ),
-	backgroundFill: rgba( LIGHT_GRAY[ 300 ], 0.8 ),
-};
-
-// Additional colors.
-// Some are from https://make.wordpress.org/design/handbook/foundations/colors/.
-
-const BLUE = {
-	wordpress: {
-		700: '#00669b',
-	},
-	dark: {
-		900: '#0071a1',
-	},
-	medium: {
-		900: '#006589',
-		800: '#00739c',
-		700: '#007fac',
-		600: '#008dbe',
-		500: '#00a0d2',
-		400: '#33b3db',
-		300: '#66c6e4',
-		200: '#bfe7f3',
-		100: '#e5f5fa',
-		highlight: '#b3e7fe',
-		focus: '#007cba',
-	},
 };
 
+// Matches @wordpress/base-styles
 const ALERT = {
 	yellow: '#f0b849',
 	red: '#d94f4f',
 	green: '#4ab866',
 };
 
+// Matches @wordpress/base-styles
 const ADMIN = {
-	theme: `var( --wp-admin-theme-color, ${ BLUE.wordpress[ 700 ] })`,
-	themeDark10: `var( --wp-admin-theme-color-darker-10, ${ BLUE.medium.focus })`,
+	theme: 'var( --wp-admin-theme-color, #007cba)',
+	themeDark10: 'var( --wp-admin-theme-color-darker-10, #006ba1)',
 };
 
-// Namespaced values for raw colors hex codes.
 const UI = {
 	theme: ADMIN.theme,
-	background: BASE.white,
-	backgroundDisabled: LIGHT_GRAY[ 200 ],
-	border: G2.gray[ 700 ],
-	borderHover: G2.gray[ 700 ],
+	background: white,
+	backgroundDisabled: LIGHT_GRAY[ 200 ], // TODO: Replace with WordPress gray
+	border: GRAY[ 700 ],
+	borderHover: GRAY[ 700 ],
 	borderFocus: ADMIN.themeDark10,
-	borderDisabled: G2.gray[ 400 ],
-	borderLight: G2.gray[ 300 ],
-	label: DARK_GRAY[ 500 ],
-	textDisabled: DARK_GRAY[ 150 ],
-	textDark: BASE.white,
-	textLight: BASE.black,
+	borderDisabled: GRAY[ 400 ],
+	textDisabled: DARK_GRAY[ 150 ], // TODO: Replace with WordPress gray
+	textDark: white,
+
+	// Matches @wordpress/base-styles
+	darkGrayPlaceholder: rgba( GRAY[ 900 ], 0.62 ),
+	lightGrayPlaceholder: rgba( white, 0.65 ),
 };
 
-// Using Object.assign instead of { ...spread } syntax helps TypeScript
-// to extract the correct type defs here.
-export const COLORS = Object.assign( {}, BASE, {
+export const COLORS = Object.freeze( {
+	/**
+	 * @deprecated Try to use `gray` instead.
+	 */
 	darkGray: DARK_GRAY,
-	darkOpacity: DARK_OPACITY,
-	darkOpacityLight: DARK_OPACITY_LIGHT,
-	mediumGray: G2.mediumGray,
 	/**
-	 * The main gray color object (since Apr 16, 2022).
-	 *
-	 * We are in the process of simplifying the colors in this file,
-	 * please prefer this `gray` object in the meantime.
+	 * The main gray color object.
+	 */
+	gray: GRAY,
+	/**
+	 * @deprecated Try to use `gray` instead.
 	 */
-	gray: G2.gray,
-	lightGray: merge( {}, LIGHT_GRAY, G2.lightGray ),
-	lightGrayLight: LIGHT_OPACITY_LIGHT,
-	blue: merge( {}, BLUE, G2.blue ),
+	lightGray: LIGHT_GRAY,
+	white,
 	alert: ALERT,
-	admin: ADMIN,
 	ui: UI,
 } );
 
diff --git a/packages/components/src/utils/config-values.js b/packages/components/src/utils/config-values.js
index 8f3e044261d730..05364a34a5eed1 100644
--- a/packages/components/src/utils/config-values.js
+++ b/packages/components/src/utils/config-values.js
@@ -18,7 +18,7 @@ const CONTROL_PROPS = {
 	controlBorderColor: COLORS.gray[ 700 ],
 	controlBoxShadow: 'transparent',
 	controlBorderColorHover: COLORS.gray[ 700 ],
-	controlBoxShadowFocus: `0 0 0 0.5px ${ COLORS.admin.theme }`,
+	controlBoxShadowFocus: `0 0 0 0.5px ${ COLORS.ui.theme }`,
 	controlDestructiveBorderColor: COLORS.alert.red,
 	controlHeight: CONTROL_HEIGHT,
 	controlHeightXSmall: `calc( ${ CONTROL_HEIGHT } * 0.6 )`,
diff --git a/packages/components/src/utils/input/input-control.js b/packages/components/src/utils/input/input-control.js
index 1a14aef8749ef7..c550a558d6d4e2 100644
--- a/packages/components/src/utils/input/input-control.js
+++ b/packages/components/src/utils/input/input-control.js
@@ -33,30 +33,30 @@ export const inputControl = css`
 
 	// Use opacity to work in various editor styles.
 	&::-webkit-input-placeholder {
-		color: ${ COLORS.darkGray.placeholder };
+		color: ${ COLORS.ui.darkGrayPlaceholder };
 	}
 
 	&::-moz-placeholder {
 		opacity: 1; // Necessary because Firefox reduces this from 1.
-		color: ${ COLORS.darkGray.placeholder };
+		color: ${ COLORS.ui.darkGrayPlaceholder };
 	}
 
 	&:-ms-input-placeholder {
-		color: ${ COLORS.darkGray.placeholder };
+		color: ${ COLORS.ui.darkGrayPlaceholder };
 	}
 
 	.is-dark-theme & {
 		&::-webkit-input-placeholder {
-			color: ${ COLORS.lightGray.placeholder };
+			color: ${ COLORS.ui.lightGrayPlaceholder };
 		}
 
 		&::-moz-placeholder {
 			opacity: 1; // Necessary because Firefox reduces this from 1.
-			color: ${ COLORS.lightGray.placeholder };
+			color: ${ COLORS.ui.lightGrayPlaceholder };
 		}
 
 		&:-ms-input-placeholder {
-			color: ${ COLORS.lightGray.placeholder };
+			color: ${ COLORS.ui.lightGrayPlaceholder };
 		}
 	}
 `;