diff --git a/.eslintrc.js b/.eslintrc.js
index b17346875ca097..554d52e2f5299d 100644
--- a/.eslintrc.js
+++ b/.eslintrc.js
@@ -144,6 +144,7 @@ module.exports = {
 							'toString',
 							'trim',
 							'truncate',
+							'uniq',
 							'uniqBy',
 							'uniqueId',
 							'uniqWith',
diff --git a/bin/plugin/commands/changelog.js b/bin/plugin/commands/changelog.js
index 6e189352201ef0..778286db23a884 100644
--- a/bin/plugin/commands/changelog.js
+++ b/bin/plugin/commands/changelog.js
@@ -1,7 +1,7 @@
 /**
  * External dependencies
  */
-const { groupBy, escapeRegExp, uniq, flow, sortBy } = require( 'lodash' );
+const { groupBy, escapeRegExp, flow, sortBy } = require( 'lodash' );
 const Octokit = require( '@octokit/rest' );
 const { sprintf } = require( 'sprintf-js' );
 const semver = require( 'semver' );
@@ -194,13 +194,15 @@ const REWORD_TERMS = {
  * @return {string[]} Type candidates.
  */
 function getTypesByLabels( labels ) {
-	return uniq(
-		labels
-			.filter( ( label ) =>
-				Object.keys( LABEL_TYPE_MAPPING ).includes( label )
-			)
-			.map( ( label ) => LABEL_TYPE_MAPPING[ label ] )
-	);
+	return [
+		...new Set(
+			labels
+				.filter( ( label ) =>
+					Object.keys( LABEL_TYPE_MAPPING ).includes( label )
+				)
+				.map( ( label ) => LABEL_TYPE_MAPPING[ label ] )
+		),
+	];
 }
 
 /**
diff --git a/packages/babel-plugin-makepot/index.js b/packages/babel-plugin-makepot/index.js
index 2e72d69dee35ba..52bb2dabf135bc 100644
--- a/packages/babel-plugin-makepot/index.js
+++ b/packages/babel-plugin-makepot/index.js
@@ -36,7 +36,6 @@ const { po } = require( 'gettext-parser' );
 const {
 	pick,
 	reduce,
-	uniq,
 	forEach,
 	sortBy,
 	isEqual,
@@ -347,8 +346,8 @@ module.exports = () => {
 												memo[ msgctxt ][ msgid ]
 											)
 										) {
-											translation.comments.reference =
-												uniq(
+											translation.comments.reference = [
+												...new Set(
 													[
 														memo[ msgctxt ][ msgid ]
 															.comments.reference,
@@ -357,7 +356,8 @@ module.exports = () => {
 													]
 														.join( '\n' )
 														.split( '\n' )
-												).join( '\n' );
+												),
+											].join( '\n' );
 										}
 
 										memo[ msgctxt ][ msgid ] = translation;
diff --git a/packages/block-editor/src/components/block-switcher/index.js b/packages/block-editor/src/components/block-switcher/index.js
index 692cf9cfb6d42a..dd3eb055ebd671 100644
--- a/packages/block-editor/src/components/block-switcher/index.js
+++ b/packages/block-editor/src/components/block-switcher/index.js
@@ -1,7 +1,7 @@
 /**
  * External dependencies
  */
-import { castArray, uniq } from 'lodash';
+import { castArray } from 'lodash';
 
 /**
  * WordPress dependencies
@@ -64,7 +64,7 @@ export const BlockSwitcherDropdownMenu = ( { clientIds, blocks } ) => {
 				_icon = blockInformation?.icon; // Take into account active block variations.
 			} else {
 				const isSelectionOfSameType =
-					uniq( blocks.map( ( { name } ) => name ) ).length === 1;
+					new Set( blocks.map( ( { name } ) => name ) ).size === 1;
 				// When selection consists of blocks of multiple types, display an
 				// appropriate icon to communicate the non-uniformity.
 				_icon = isSelectionOfSameType
diff --git a/packages/block-editor/src/components/date-format-picker/index.js b/packages/block-editor/src/components/date-format-picker/index.js
index 7d5ae7f53e5e55..555910d70f76ce 100644
--- a/packages/block-editor/src/components/date-format-picker/index.js
+++ b/packages/block-editor/src/components/date-format-picker/index.js
@@ -1,8 +1,3 @@
-/**
- * External dependencies
- */
-import { uniq } from 'lodash';
-
 /**
  * WordPress dependencies
  */
@@ -83,15 +78,17 @@ function NonDefaultControls( { format, onChange } ) {
 	// 2022) in German (de). The resultant array is de-duplicated as some
 	// languages will use the same format string for short, medium, and long
 	// formats.
-	const suggestedFormats = uniq( [
-		'Y-m-d',
-		_x( 'n/j/Y', 'short date format' ),
-		_x( 'n/j/Y g:i A', 'short date format with time' ),
-		_x( 'M j, Y', 'medium date format' ),
-		_x( 'M j, Y g:i A', 'medium date format with time' ),
-		_x( 'F j, Y', 'long date format' ),
-		_x( 'M j', 'short date format without the year' ),
-	] );
+	const suggestedFormats = [
+		...new Set( [
+			'Y-m-d',
+			_x( 'n/j/Y', 'short date format' ),
+			_x( 'n/j/Y g:i A', 'short date format with time' ),
+			_x( 'M j, Y', 'medium date format' ),
+			_x( 'M j, Y g:i A', 'medium date format with time' ),
+			_x( 'F j, Y', 'long date format' ),
+			_x( 'M j', 'short date format without the year' ),
+		] ),
+	];
 
 	const suggestedOptions = suggestedFormats.map(
 		( suggestedFormat, index ) => ( {
diff --git a/packages/block-editor/src/hooks/generated-class-name.js b/packages/block-editor/src/hooks/generated-class-name.js
index b5ca340cc3b4c2..0f4e5f43576fa9 100644
--- a/packages/block-editor/src/hooks/generated-class-name.js
+++ b/packages/block-editor/src/hooks/generated-class-name.js
@@ -1,8 +1,3 @@
-/**
- * External dependencies
- */
-import { uniq } from 'lodash';
-
 /**
  * WordPress dependencies
  */
@@ -26,10 +21,12 @@ export function addGeneratedClassName( extraProps, blockType ) {
 			// We have some extra classes and want to add the default classname
 			// We use uniq to prevent duplicate classnames.
 
-			extraProps.className = uniq( [
-				getBlockDefaultClassName( blockType.name ),
-				...extraProps.className.split( ' ' ),
-			] )
+			extraProps.className = [
+				...new Set( [
+					getBlockDefaultClassName( blockType.name ),
+					...extraProps.className.split( ' ' ),
+				] ),
+			]
 				.join( ' ' )
 				.trim();
 		} else {
diff --git a/packages/blocks/src/api/factory.js b/packages/blocks/src/api/factory.js
index 71b370f79c1cbd..e7e8e9f114a10a 100644
--- a/packages/blocks/src/api/factory.js
+++ b/packages/blocks/src/api/factory.js
@@ -9,7 +9,6 @@ import {
 	filter,
 	first,
 	has,
-	uniq,
 	isEmpty,
 	map,
 } from 'lodash';
@@ -348,10 +347,12 @@ export function getPossibleBlockTransformations( blocks ) {
 	const blockTypesForToTransforms =
 		getBlockTypesForPossibleToTransforms( blocks );
 
-	return uniq( [
-		...blockTypesForFromTransforms,
-		...blockTypesForToTransforms,
-	] );
+	return [
+		...new Set( [
+			...blockTypesForFromTransforms,
+			...blockTypesForToTransforms,
+		] ),
+	];
 }
 
 /**
diff --git a/packages/components/CHANGELOG.md b/packages/components/CHANGELOG.md
index 3d0002b5554054..25ab007fa04d87 100644
--- a/packages/components/CHANGELOG.md
+++ b/packages/components/CHANGELOG.md
@@ -23,6 +23,9 @@
 -   `DateTimePicker`, `TimePicker`, `DatePicker`: Switch from `moment` to `date-fns` ([#43005](https://github.com/WordPress/gutenberg/pull/43005)).
 -   `DatePicker`: Switch from `react-dates` to `use-lilius` ([#43005](https://github.com/WordPress/gutenberg/pull/43005)).
 -   `convertLTRToRTL()`: Refactor away from `_.mapKeys()` ([#43258](https://github.com/WordPress/gutenberg/pull/43258/)).
+-   `FormTokenField`: Refactor away from `_.uniq()` ([#43330](https://github.com/WordPress/gutenberg/pull/43330/)).
+-   `contextConnect`: Refactor away from `_.uniq()` ([#43330](https://github.com/WordPress/gutenberg/pull/43330/)).
+-   `ColorPalette`: Refactor away from `_.uniq()` ([#43330](https://github.com/WordPress/gutenberg/pull/43330/)).
 
 ## 19.17.0 (2022-08-10)
 
diff --git a/packages/components/src/color-palette/index.native.js b/packages/components/src/color-palette/index.native.js
index 10b0b0df94de61..5ce545b3c64ffa 100644
--- a/packages/components/src/color-palette/index.native.js
+++ b/packages/components/src/color-palette/index.native.js
@@ -11,7 +11,7 @@ import {
 	Platform,
 	Text,
 } from 'react-native';
-import { map, uniq } from 'lodash';
+import { map } from 'lodash';
 
 /**
  * WordPress dependencies
@@ -63,11 +63,15 @@ function ColorPalette( {
 	const scale = useRef( new Animated.Value( 1 ) ).current;
 	const opacity = useRef( new Animated.Value( 1 ) ).current;
 
-	const defaultColors = uniq( map( defaultSettings.colors, 'color' ) );
-	const mergedColors = uniq( map( defaultSettings.allColors, 'color' ) );
-	const defaultGradientColors = uniq(
-		map( defaultSettings.gradients, 'gradient' )
-	);
+	const defaultColors = [
+		...new Set( map( defaultSettings.colors, 'color' ) ),
+	];
+	const mergedColors = [
+		...new Set( map( defaultSettings.allColors, 'color' ) ),
+	];
+	const defaultGradientColors = [
+		...new Set( map( defaultSettings.gradients, 'gradient' ) ),
+	];
 	const colors = isGradientSegment ? defaultGradientColors : defaultColors;
 
 	const customIndicatorColor = isGradientSegment
diff --git a/packages/components/src/form-token-field/index.tsx b/packages/components/src/form-token-field/index.tsx
index 29475ec7d4ee71..12bfa781ed6117 100644
--- a/packages/components/src/form-token-field/index.tsx
+++ b/packages/components/src/form-token-field/index.tsx
@@ -1,7 +1,7 @@
 /**
  * External dependencies
  */
-import { last, clone, uniq, map, some } from 'lodash';
+import { last, clone, map, some } from 'lodash';
 import classnames from 'classnames';
 import type { KeyboardEvent, MouseEvent, TouchEvent } from 'react';
 
@@ -409,12 +409,14 @@ export function FormTokenField( props: FormTokenFieldProps ) {
 	}
 
 	function addNewTokens( tokens: string[] ) {
-		const tokensToAdd = uniq(
-			tokens
-				.map( saveTransform )
-				.filter( Boolean )
-				.filter( ( token ) => ! valueContainsToken( token ) )
-		);
+		const tokensToAdd = [
+			...new Set(
+				tokens
+					.map( saveTransform )
+					.filter( Boolean )
+					.filter( ( token ) => ! valueContainsToken( token ) )
+			),
+		];
 
 		if ( tokensToAdd.length > 0 ) {
 			const newValue = clone( value );
diff --git a/packages/components/src/ui/context/context-connect.ts b/packages/components/src/ui/context/context-connect.ts
index 63aba66e42d778..563f90e1eecb4b 100644
--- a/packages/components/src/ui/context/context-connect.ts
+++ b/packages/components/src/ui/context/context-connect.ts
@@ -1,7 +1,6 @@
 /**
  * External dependencies
  */
-import { uniq } from 'lodash';
 import type { ForwardedRef, ReactChild, ReactNode } from 'react';
 
 /**
@@ -70,7 +69,9 @@ export function contextConnect< P >(
 	WrappedComponent.displayName = namespace;
 
 	// @ts-ignore internal property
-	WrappedComponent[ CONNECT_STATIC_NAMESPACE ] = uniq( mergedNamespace );
+	WrappedComponent[ CONNECT_STATIC_NAMESPACE ] = [
+		...new Set( mergedNamespace ),
+	];
 
 	// @ts-ignore WordPressComponent property
 	WrappedComponent.selector = `.${ getStyledClassNameFromKey( namespace ) }`;
diff --git a/test/integration/fixtures/utils.js b/test/integration/fixtures/utils.js
index afbe494c3dad17..7b8d5fc2c9e055 100644
--- a/test/integration/fixtures/utils.js
+++ b/test/integration/fixtures/utils.js
@@ -3,7 +3,6 @@
  */
 import fs from 'fs';
 import path from 'path';
-import { uniq } from 'lodash';
 
 const FIXTURES_DIR = path.join( __dirname, 'blocks' );
 
@@ -31,12 +30,14 @@ export function getAvailableBlockFixturesBasenames() {
 	//  - fixture.json            : blocks structure
 	//  - fixture.serialized.html : re-serialized content
 	// Get the "base" name for each fixture first.
-	return uniq(
-		fs
-			.readdirSync( FIXTURES_DIR )
-			.filter( ( f ) => /(\.html|\.json)$/.test( f ) )
-			.map( ( f ) => f.replace( /\..+$/, '' ) )
-	);
+	return [
+		...new Set(
+			fs
+				.readdirSync( FIXTURES_DIR )
+				.filter( ( f ) => /(\.html|\.json)$/.test( f ) )
+				.map( ( f ) => f.replace( /\..+$/, '' ) )
+		),
+	];
 }
 
 /**