diff --git a/bin/build-plugin-zip.sh b/bin/build-plugin-zip.sh
index a518e83b0e311..7e76a2032228c 100755
--- a/bin/build-plugin-zip.sh
+++ b/bin/build-plugin-zip.sh
@@ -107,7 +107,7 @@ npm run build
 php bin/generate-gutenberg-php.php > gutenberg.tmp.php
 mv gutenberg.tmp.php gutenberg.php
 
-build_files=$(ls build/*/*.{js,css} build/block-library/blocks/*.php)
+build_files=$(ls build/*/*.{js,css,deps.json} build/block-library/blocks/*.php)
 
 # Generate the plugin zip file.
 status "Creating archive... 🎁"
diff --git a/lib/client-assets.php b/lib/client-assets.php
index d9fcc8105249b..47949cdccea4f 100644
--- a/lib/client-assets.php
+++ b/lib/client-assets.php
@@ -114,9 +114,14 @@ function gutenberg_override_translation_file( $file, $handle ) {
 		return $file;
 	}
 
-	// Only override script handles generated from the Gutenberg plugin.
-	$packages_dependencies = include dirname( __FILE__ ) . '/packages-dependencies.php';
-	if ( ! isset( $packages_dependencies[ $handle ] ) ) {
+	// Ignore scripts whose handle does not have the "wp-" prefix.
+	if ( 'wp-' !== substr( $handle, 0, 3 ) ) {
+		return $file;
+	}
+
+	// Ignore scripts that are not found in the expected `build/` location.
+	$script_path = gutenberg_dir_path() . 'build/' . substr( $handle, 3 ) . '/index.js';
+	if ( ! file_exists( $script_path ) ) {
 		return $file;
 	}
 
@@ -177,17 +182,37 @@ function gutenberg_override_style( $handle, $src, $deps = array(), $ver = false,
  * @since 4.5.0
  */
 function gutenberg_register_packages_scripts() {
-	$packages_dependencies = include dirname( __FILE__ ) . '/packages-dependencies.php';
+	foreach ( glob( gutenberg_dir_path() . 'build/*/index.js' ) as $path ) {
+		// Prefix `wp-` to package directory to get script handle.
+		// For example, `…/build/a11y/index.js` becomes `wp-a11y`.
+		$handle = 'wp-' . basename( dirname( $path ) );
+
+		// Replace `.js` extension with `.deps.json` to find the generated dependencies file.
+		$dependencies_file = substr( $path, 0, -3 ) . '.deps.json';
+
+		$dependencies = is_readable( $dependencies_file )
+			? json_decode( file_get_contents( $dependencies_file ) )
+			: array();
+
+		// Add dependencies that cannot be detected and generated by build tools.
+		switch ( $handle ) {
+			case 'wp-block-library':
+				array_push( $dependencies, 'editor' );
+				break;
+
+			case 'wp-edit-post':
+				array_push( $dependencies, 'media-models', 'media-views', 'postbox' );
+				break;
+		}
+
+		// Get the path from Gutenberg directory as expected by `gutenberg_url`.
+		$gutenberg_path = substr( $path, strlen( gutenberg_dir_path() ) );
 
-	foreach ( $packages_dependencies as $handle => $dependencies ) {
-		// Remove `wp-` prefix from the handle to get the package's name.
-		$package_name = strpos( $handle, 'wp-' ) === 0 ? substr( $handle, 3 ) : $handle;
-		$path         = "build/$package_name/index.js";
 		gutenberg_override_script(
 			$handle,
-			gutenberg_url( $path ),
-			array_merge( $dependencies, array( 'wp-polyfill' ) ),
-			filemtime( gutenberg_dir_path() . $path ),
+			gutenberg_url( $gutenberg_path ),
+			$dependencies,
+			filemtime( $path ),
 			true
 		);
 	}
diff --git a/lib/packages-dependencies.php b/lib/packages-dependencies.php
deleted file mode 100644
index 8a1f78fafe456..0000000000000
--- a/lib/packages-dependencies.php
+++ /dev/null
@@ -1,265 +0,0 @@
-<?php
-/**
- * Returns array with the list of WordPress packages and their dependencies.
- *
- * @package gutenberg
- */
-
-return array(
-	'wp-a11y'                               => array(
-		'wp-dom-ready',
-	),
-	'wp-annotations'                        => array(
-		'wp-data',
-		'wp-hooks',
-		'wp-i18n',
-		'wp-rich-text',
-	),
-	'wp-api-fetch'                          => array(
-		'wp-i18n',
-		'wp-url',
-	),
-	'wp-autop'                              => array(),
-	'wp-blob'                               => array(),
-	'wp-block-library'                      => array(
-		'editor',
-		'lodash',
-		'wp-api-fetch',
-		'wp-autop',
-		'wp-blob',
-		'wp-block-editor',
-		'wp-blocks',
-		'wp-components',
-		'wp-compose',
-		'wp-core-data',
-		'wp-data',
-		'wp-date',
-		'wp-editor',
-		'wp-element',
-		'wp-html-entities',
-		'wp-i18n',
-		'wp-keycodes',
-		'wp-rich-text',
-		'wp-url',
-		'wp-viewport',
-	),
-	'wp-block-serialization-default-parser' => array(),
-	'wp-block-serialization-spec-parser'    => array(),
-	'wp-block-editor'                       => array(
-		'lodash',
-		'wp-a11y',
-		'wp-blob',
-		'wp-blocks',
-		'wp-compose',
-		'wp-components',
-		'wp-data',
-		'wp-dom',
-		'wp-element',
-		'wp-hooks',
-		'wp-html-entities',
-		'wp-i18n',
-		'wp-is-shallow-equal',
-		'wp-keycodes',
-		'wp-rich-text',
-		'wp-token-list',
-		'wp-url',
-		'wp-viewport',
-		'wp-wordcount',
-	),
-	'wp-blocks'                             => array(
-		'lodash',
-		'wp-autop',
-		'wp-blob',
-		'wp-block-serialization-default-parser',
-		'wp-data',
-		'wp-dom',
-		'wp-element',
-		'wp-hooks',
-		'wp-html-entities',
-		'wp-i18n',
-		'wp-is-shallow-equal',
-		'wp-shortcode',
-	),
-	'wp-components'                         => array(
-		'lodash',
-		'moment',
-		'wp-a11y',
-		'wp-api-fetch',
-		'wp-compose',
-		'wp-dom',
-		'wp-element',
-		'wp-hooks',
-		'wp-html-entities',
-		'wp-i18n',
-		'wp-is-shallow-equal',
-		'wp-keycodes',
-		'wp-rich-text',
-		'wp-url',
-	),
-	'wp-compose'                            => array(
-		'lodash',
-		'wp-element',
-		'wp-is-shallow-equal',
-	),
-	'wp-core-data'                          => array(
-		'lodash',
-		'wp-api-fetch',
-		'wp-data',
-		'wp-deprecated',
-		'wp-url',
-	),
-	'wp-data'                               => array(
-		'lodash',
-		'wp-compose',
-		'wp-deprecated',
-		'wp-element',
-		'wp-is-shallow-equal',
-		'wp-priority-queue',
-		'wp-redux-routine',
-	),
-	'wp-date'                               => array(
-		'moment',
-	),
-	'wp-deprecated'                         => array(
-		'wp-hooks',
-	),
-	'wp-dom'                                => array(
-		'lodash',
-	),
-	'wp-dom-ready'                          => array(),
-	'wp-edit-post'                          => array(
-		'jquery',
-		'lodash',
-		'postbox',
-		'media-models',
-		'media-views',
-		'wp-a11y',
-		'wp-api-fetch',
-		'wp-block-editor',
-		'wp-block-library',
-		'wp-blocks',
-		'wp-components',
-		'wp-compose',
-		'wp-core-data',
-		'wp-data',
-		'wp-dom-ready',
-		'wp-editor',
-		'wp-element',
-		'wp-embed',
-		'wp-i18n',
-		'wp-keycodes',
-		'wp-notices',
-		'wp-nux',
-		'wp-plugins',
-		'wp-url',
-		'wp-viewport',
-	),
-	'wp-edit-widgets'                       => array(
-		'wp-block-editor',
-		'wp-block-library',
-		'wp-components',
-		'wp-element',
-		'wp-i18n',
-	),
-	'wp-editor'                             => array(
-		'lodash',
-		'wp-a11y',
-		'wp-api-fetch',
-		'wp-blob',
-		'wp-block-editor',
-		'wp-blocks',
-		'wp-components',
-		'wp-compose',
-		'wp-core-data',
-		'wp-data',
-		'wp-date',
-		'wp-deprecated',
-		'wp-dom',
-		'wp-element',
-		'wp-hooks',
-		'wp-html-entities',
-		'wp-i18n',
-		'wp-is-shallow-equal',
-		'wp-keycodes',
-		'wp-notices',
-		'wp-nux',
-		'wp-rich-text',
-		'wp-token-list',
-		'wp-url',
-		'wp-viewport',
-		'wp-wordcount',
-	),
-	'wp-element'                            => array(
-		'lodash',
-		'react',
-		'react-dom',
-		'wp-escape-html',
-	),
-	'wp-escape-html'                        => array(),
-	'wp-format-library'                     => array(
-		'wp-block-editor',
-		'wp-components',
-		'wp-editor',
-		'wp-element',
-		'wp-i18n',
-		'wp-keycodes',
-		'wp-rich-text',
-		'wp-url',
-	),
-	'wp-hooks'                              => array(),
-	'wp-html-entities'                      => array(),
-	'wp-i18n'                               => array(),
-	'wp-is-shallow-equal'                   => array(),
-	'wp-keycodes'                           => array(
-		'lodash',
-		'wp-i18n',
-	),
-	'wp-list-reusable-blocks'               => array(
-		'lodash',
-		'wp-api-fetch',
-		'wp-components',
-		'wp-compose',
-		'wp-element',
-		'wp-i18n',
-	),
-	'wp-notices'                            => array(
-		'lodash',
-		'wp-a11y',
-		'wp-data',
-	),
-	'wp-nux'                                => array(
-		'lodash',
-		'wp-components',
-		'wp-compose',
-		'wp-data',
-		'wp-element',
-		'wp-i18n',
-	),
-	'wp-plugins'                            => array(
-		'lodash',
-		'wp-compose',
-		'wp-element',
-		'wp-hooks',
-	),
-	'wp-priority-queue'                     => array(),
-	'wp-redux-routine'                      => array(),
-	'wp-rich-text'                          => array(
-		'lodash',
-		'wp-data',
-		'wp-escape-html',
-	),
-	'wp-shortcode'                          => array(
-		'lodash',
-	),
-	'wp-token-list'                         => array(
-		'lodash',
-	),
-	'wp-url'                                => array(),
-	'wp-viewport'                           => array(
-		'lodash',
-		'wp-compose',
-		'wp-data',
-		'wp-element',
-	),
-	'wp-wordcount'                          => array(),
-);
diff --git a/packages/scripts/config/webpack.config.js b/packages/scripts/config/webpack.config.js
index 44f173d958e0f..5a3b30163a432 100644
--- a/packages/scripts/config/webpack.config.js
+++ b/packages/scripts/config/webpack.config.js
@@ -67,7 +67,7 @@ const config = {
 		// WP_LIVE_RELOAD_PORT global variable changes port on which live reload works
 		// when running watch mode.
 		! isProduction && new LiveReloadPlugin( { port: process.env.WP_LIVE_RELOAD_PORT || 35729 } ),
-		new DependencyExtractionWebpackPlugin(),
+		new DependencyExtractionWebpackPlugin( { injectPolyfill: true } ),
 	].filter( Boolean ),
 	stats: {
 		children: false,