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Publications
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Conference Abstracts      Google Scholar       PubMed       ORCID      

Wheeler Lab Member      *Loyola Student

2018

Mogil LS, *Andaleon A, *Badalamenti A, Dickinson SP, Guo X, Rotter JI, Johnson WC, Im HK, Liu Y, Wheeler HE. (2018) Genetic architecture of gene expression traits across diverse populations. PLOS Genetics 14(8):e1007586. PMID30096133 DOI

Wyss AB, Sofer T, Lee MK, Terzikhan N, Nguyen JN, Lahousse L, Latourelle JC, Smith AV, Bartz TM, Feitosa MF, Gao W, Ahluwalia TS, Tang W, Oldmeadow C, Duan Q, de Jong K, Wojczynski MK, Wang XQ, Noordam R, Hartwig FP, Jackson VE, Wang T, Obeidat M, Hobbs BD, Huan T, Gui H, Parker MM, Hu D, Mogil LS, Kichaev G, Jin J, Graff M, Harris TB, Kalhan R, Heckbert SR, Paternoster L, Burkart KM, Liu Y, Holliday EG, Wilson JG, Vonk JM, Sanders JL, Barr RG, de Mutsert R, Menezes AMB, Adams HHH, van den Berge M, Joehanes R, Levin AM, Liberto J, Launer LJ, Morrison AC, Sitlani CM, Celedón JC, Kritchevsky SB, Scott RJ, Christensen K, Rotter JI, Bonten TN, Wehrmeister FC, Bossé Y, Xiao S, Oh S, Franceschini N, Brody JA, Kaplan RC, Lohman K, McEvoy M, Province MA, Rosendaal FR, Taylor KD, Nickle DC, Williams LK, Burchard EG, Wheeler HE, Sin DD, Gudnason V, North KE, Fornage M, Psaty BM, Myers RH, O'Connor G, Hansen T, Laurie CC, Cassano PA, Sung J, Kim WJ, Attia JR, Lange L, Boezen HM, Thyagarajan B, Rich SS, Mook-Kanamori DO, Horta BL, Uitterlinden AG, Im HK, Cho MH, Brusselle GG, Gharib SA, Dupuis J, Manichaikul A, London SJ. (2018) Multiethnic meta-analysis identifies ancestry-specific and cross-ancestry loci for pulmonary function. Nature Communications 9(1):2976. PMID30061609 DOI

Barbeira AN, Pividori MD, Zheng J, Wheeler HE, Nicolae DL, Im HK. (2018) Integrating Predicted Transcriptome From Multiple Tissues Improves Association Detection. BioRxiv Preprint

Li R, Kim D, Wheeler HE, Dudek SM, Dolan ME, Ritchie MD. (2018) Integration of genetic and functional genomics data to uncover chemotherapeutic induced cytotoxicity. The Pharmacogenomics Journal PMID29795408 DOI

Barbeira AN, Dickinson SP, Bonazzola R, Zheng J, Wheeler HE, Torres JM, Torstenson ES, Shah KP, Garcia T, Edwards TL, Stahl EA, Huckins LM, GTEx Consortium, Nicolae DL, Cox NJ, Im HK. (2018) Exploring the phenotypic consequences of tissue specific gene expression variation inferred from GWAS summary statistics. Nature Communications 9(1):1825. PMID29739930 DOI

*Andaleon A, Mogil LS, Wheeler HE. (2018) Gene-based association study for lipid traits in diverse cohorts implicates BACE1 and SIDT2 regulation in triglyceride levels. PeerJ 6:e4314. PMID29404214 DOI

2017

Dolan ME, El Charif O, Wheeler HE, Gamazon ER, Ardeshir-Rouhani-Fard S, Monahan P, Feldman DR, Hamilton R, Vaughn DJ, Beard C, Fung C, Fossa SD, Hertz DL, Mushiroda T, Kubo M, Einhorn LH, Cox N, Travis L. (2017) Clinical and genome-wide analysis of cisplatin-induced peripheral neuropathy in survivors of adult-onset cancer. Clinical Cancer Research 23(19):5757-5768. PMID28611204

Wheeler HE, Gamazon ER, Frisina R, *Perez-Cervantes C, El Charif O, Mapes B, Fossa SD, Feldman D, Hamilton R, Vaughn DJ, Beard C, Fung C, Kollmannsberger C, Kim J, Mushiroda T, Kubo M, Ardeshir-Rouhani-Fard S, Einhorn LH, Cox N, Dolan ME, Travis L. (2017) Variants in WFS1 and other Mendelian deafness genes are associated with cisplatin-associated ototoxicity. Clinical Cancer Research 23(13):3325-33. PMID28039263pdfHighlights Feature

Wing C, Komatsu M, Delaney SM, Krause M, Wheeler HE, Dolan ME. (2017) Application of stem cell derived neuronal cells to evaluate neurotoxic chemotherapy. Stem Cell Research 22:79-88. PMID28645005

Eadon MT, Hause RJ, Stark AL, Cheng YH, Wheeler HE, Burgess KS, Benson EA, Cunningham PN, Bacallao RL, Dagher PC, Skaar TC, Dolan ME. (2017) Genetic variants contributing to colistin cytotoxicity: identification of TGIF1 and HOXD10 using a population genomics approach. International Journal Molecular Sciences 18(3). PMC5372673

2016

Wheeler HE, Shah KP, *Brenner J, Garcia T, Aquino-Michaels K, GTEx Consortium, Cox NJ, Nicolae DL, Im HK. (2016) Survey of the heritability and sparsity of gene expression traits across human tissues. PLOS Genetics 12(11):e1006423. PMC5106030

Frisina RD, Wheeler HE, Fossa SD, Kerns SL, Fung C, Sesso HD, Monahan PO, Feldman DR, Hamilton R, Vaughn DJ, Beard CJ, Budnick A, Johnson EM, Ardeshir-Rouhani-Fard S, Einhorn LH, Lipshultz SE, Dolan ME, Travis LB. (2016) Comprehensive audiometric analysis of hearing impairment and tinnitus after cisplatin-based chemotherapy in survivors of adult-onset cancer. Journal of Clinical Oncology 34(23):2712-20. PMC5019759 Contributed equally.

Hertz DL, Owzar K, Lessans S, Wing C, Jiang C, Kelly WK, Patel JN, Halabi S, Furukawa Y, Wheeler HE, Sibley A, Lassiter C, Weisman LS, Watson D, Krens SD, Mulkey F, Renn CL, Small EJ, Febbo PG, Shterev I, Kroetz D, Friedman PN, Mahoney JF, Carducci MA, Kelley MJ, Nakamura Y, Kubo M, Dorsey SG, Dolan ME, Morris MJ, Ratain MJ, McLeod HL. (2016) Pharmacogenetic discovery in CALGB (Alliance) 90401 and mechanistic validation of a VAC14 polymorphism that increases risk of docetaxel-induced neuropathy. Clinical Cancer Research 22(19):4890-4900. PMC5050068

2015

Gamazon ER, Wheeler HE, Shah KP, Mozaffari SV, Aquino-Michaels K, Carroll RJ, Eyler AE, Denny JC, GTEx Consortium, Nicolae DL, Cox NJ, Im HK. (2015) A gene-based association method for mapping traits using reference transcriptome data. Nature Genetics 47(9):1091-8. PMC4552594 Contributed equally.

Komatsu M, Wheeler HE, Chung S, Low SK, Wing C, Delaney SM, Gorsic LK, Takahashi A, Kubo M, Kroetz D, Zhang W, Nakamura Y, Dolan ME. (2015) Pharmacoethnicity in paclitaxel-induced sensory peripheral neuropathy. Clinical Cancer Research 21(19):4337-46. PMC4592389

Diouf B, Crews KR, Lew G, Pei D, Cheng C, Bao J, Zheng JJ, Yang W, Fan Y, Wheeler HE, Wing C, Delaney SM, Komatsu M, Paugh SW, McCorkle JR, Lu X, Winick NJ, Carroll WL, Loh ML, Hunger SP, Devidas M, Pui CH, Dolan ME, Relling MV, Evans WE. (2015) Association of an inherited genetic variant with vincristine-related peripheral neuropathy in children with acute lymphoblastic leukemia. JAMA 313(8):815-823. PMC4377066

Wheeler HE, Wing C, Delaney SM, Komatsu M, Dolan ME. (2015) Modeling chemotherapeutic neurotoxicity with human induced pluripotent stem cell-derived neuronal cells. PLOS One 10(2):e0118020. PMC4331516

2014

Thompson P, Wheeler HE, Delaney SM, Lorier R, Broeckel U, Devidas M, Reaman GH, Scorsone K, Sung L, Dolan ME, Berg SL. (2014) Pharmacokinetics and pharmacogenomics of daunorubicin in children: a report from the Children's Oncology Group. Cancer Chemotherapy and Pharmacology, 74(4):831-8. PMC4282931

Wheeler HE, Aquino-Michaels K, Gamazon ER, Trubetskoy VV, Dolan ME, Huang RS, Cox NJ, Im HK (2014) Poly-omic prediction of complex traits: OmicKriging. Genetic Epidemiology, 38(5):402-15. PMC4072756 International Genetic Epidemiology Society Robert C. Elston Best Paper Award 2014

Wheeler HE, González-Neira A, Pita G, de la Torre-Montero JC, Alonso R, Lopez-Fernandez LA, Alba E, Martín M, Dolan ME (2014) Identification of genetic variants associated with capecitabine-induced hand-foot syndrome through integration of patient and cell line genomic analyses. Pharmacogenetics and Genomics 24(5):231-7. PMC4076106

2013

Gorsic LK, Stark AL, Wheeler HE, Wong SS, Im HK, Dolan ME (2013) EPS8 inhibition increases cisplatin sensitivity in lung cancer cells. PLOS One 8(12):e82220. PMC3868552

Parsa A, Fuchsberger C…Wheeler HE…Böger CA (>100 authors) (2013) Common variants in Mendelian kidney disease genes and their association with renal function. Journal of the American Society of Nephrology 24(12):2105-17. PMC3839542

Eadon MT, Wheeler HE, Stark AL, Zhang X, Moen EL, Delaney SM, Im HK, Cunningham PN, Zhang W, Dolan ME (2013) Genetic and epigenetic variants contributing to clofarabine cytotoxicity. Human Molecular Genetics 22(19):4007-20. PMC3766179

Gamazon ER, Lamba JK, Pounds S, Stark AL, Wheeler HE, Cao X, Im HK, Mitra AK, Rubnitz JE, Ribeiro RC, Raimondi S, Campana D, Crews KR, Wong SS, Welsh M, Hulur I, Gorsic L, Hartford CM, Zhang W, Cox NJ, Dolan ME (2013) Comprehensive genetic analysis of cytarabine sensitivity in a cell-based model identifies polymorphisms associated with outcome in AML patients. Blood 121(21):4366-76. PMC3663430

Wheeler HE, Gamazon ER, Wing C, Njiaju UO, Njoku C, Baldwin RM, Owzar K, Jiang C, Watson D, Shterev I, Kubo M, Zembutsu H, Winer E, Hudis C, Shulman LN, Nakamura Y, Ratain MJ, Kroetz DL, Cox NJ, Dolan ME (2013) Integration of cell line and clinical trial genome-wide analyses supports a polygenic architecture of paclitaxel-induced sensory peripheral neuropathy. Clinical Cancer Research 19(2):491-9. PMC3549006

Wheeler HE, Maitland ML, Dolan ME, Cox NJ, Ratain MJ (2013) Cancer pharmacogenomics: strategies and challenges. Nature Reviews Genetics 14(1):23-34. PMC3668552

Wheeler HE, Gamazon ER, Stark AL, O’Donnell PH, Gorsic LK, Huang RS, Cox NJ, Dolan ME (2013) Genome-wide meta-analysis identifies variants associated with platinating agent susceptibility across populations. The Pharmacogenomics Journal 13(1):35-43. PMC3370147

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