diff --git a/R/CalculationFunctions.R b/R/CalculationFunctions.R
index 5133efc5..2908a8ce 100644
--- a/R/CalculationFunctions.R
+++ b/R/CalculationFunctions.R
@@ -511,6 +511,9 @@ calculateSectorPurchasedbySectorSourcedImpact <- function (y, model, indicator)
 #' @return A list with M_margin and N_margin
 #' @export
 calculateMarginSectorImpacts <- function(model) {
+  if (model$specs$IODataSource == "stateior") {
+    stop("Margins not available for two-region models")
+  }
   # Calculation fractions of producer price for each margin
   MarginCoefficients <- as.matrix(model$Margins[, c("Transportation", "Wholesale", "Retail")]/model$Margins[, c("ProducersValue")])
   rownames(MarginCoefficients) <- model$Margins$SectorCode
diff --git a/R/LoadIOTables.R b/R/LoadIOTables.R
index a8c30a03..163c39f8 100644
--- a/R/LoadIOTables.R
+++ b/R/LoadIOTables.R
@@ -41,8 +41,10 @@ loadIOData <- function(model, configpaths = NULL) {
     names(model$InternationalTradeAdjustment) <- model$Industries$Code_Loc
   }
   
-  # Add Margins table
-  model$Margins <- getMarginsTable(model)
+  if (model$specs$IODataSource != "stateior") {
+    # Add Margins table, currently only for one-region models (see Issue #290)
+    model$Margins <- getMarginsTable(model)
+  }
   
   # Add TaxLessSubsidies table
   model$TaxLessSubsidies <- generateTaxLessSubsidiesTable(model)