Mephedrone + Nitrous Oxide

[utaninja]

Discussed in #158

^{Originally posted by utaninja August 6, 2024}
Mephedrone + Nitrous Oxide - Low risk + synergy

There seems to be little reason to have concern about this combination.

Initially, there seemed to be some concern possibly of additional oxidative stress caused by NO2 in combination with the Mephedrone. This does not seem to be of enough concern to note however I am inquiring about this more. Leaving this here and sharing my research so far.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9738214/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4066238/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2617738/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7968496/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1821130/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4422847/

With Breads agreement, I'd like to move this combination forward. The sources aren't ideal for this however I don't see why this combination would be of notable concern past typical concern for these drugs on its own. I've linked pages to each of their pharmacology pages as sources to give more insight if someone wants to look further.

Mephedrone + Nitrous Oxide = Low Risk + Synergy
There is no apparent concern from this combination and there may also be synergy from mixing these two psychoactive drugs.

Carvalho, F., Carmo, H., Guedes de Pinho, P., Remião, F., de Lourdes Bastos, M., & Carvalho, M. (2014). Mephedrone. In P. Wexler (Ed.), Encyclopedia of Toxicology (Third Edition) (pp. 194–196). Academic Press. https://doi.org/10.1016/B978-0-12-386454-3.01189-1
Knuf, K., & Maani, C. V. (2024). Nitrous Oxide. In StatPearls. StatPearls Publishing. http://www.ncbi.nlm.nih.gov/books/NBK532922/
4-Methylmethcathinone & Nitrous Oxide - Erowid Exp - “I Think That I Just Seen Another World.” (n.d.). Retrieved August 6, 2024, from https://www.erowid.org/experiences/exp.php?ID=112811