diff --git a/.github/CONTRIBUTING.md b/.github/CONTRIBUTING.md index ff3308e2..cc2e1875 100644 --- a/.github/CONTRIBUTING.md +++ b/.github/CONTRIBUTING.md @@ -1,6 +1,6 @@ ## Contributor guidelines -First of all, thank you for contributing to yeast-GEM!! Anybody is welcome to contribute, but please abide by the following guidelines. +First of all, thank you for contributing to yeast-GEM! Anybody is welcome to contribute, but please abide by the following guidelines. You can contribute in 2 main ways: by creating issues, and by sending pull requests (PRs) with additions, deletions, corrections, etc. to the model. @@ -14,7 +14,7 @@ Report an issue at https://github.com/SysBioChalmers/yeast-GEM/issues if you not * Lacking documentation. * Any type of feedback. -If you are unsure about the issue, consider asking first in our [Gitter chat room](https://gitter.im/SysBioChalmers/yeast-GEM). +If you are unsure about the issue, consider asking first in our [Gitter chat room](https://gitter.im/SysBioChalmers/yeast-GEM) or [GitHub Discussion forum](https://github.com/SysBioChalmers/yeast-GEM/discussions). When creating the issue, please make sure: @@ -29,11 +29,11 @@ Finally, if you like yeast-GEM please remember to 'star' our Github page (click ### Contributing to the model -Want to contribute to the model with some additions or improvements? Consider starting by raising an issue and assign it to yourself to describe what you want to achieve. This way, we reduce the risk of duplicated efforts and you may also get suggestions on how to best proceed, e.g. there may be half-finished work in some branch that you could start with. Also, feel free to browse our [open issues](https://github.com/SysBioChalmers/yeast-GEM/issues) and our [ongoing projects](https://github.com/SysBioChalmers/yeast-GEM/projects): Anything tagged with "help wanted" is open to whoever wants to implement it! +Do you want to contribute to the model with some additions or improvements? Consider starting by raising an issue and assign it to yourself to describe what you want to achieve. This way, we reduce the risk of duplicated efforts and you may also get suggestions on how to best proceed, e.g. there may be half-finished work in some branch that you could start with. Also, feel free to browse our [open issues](https://github.com/SysBioChalmers/yeast-GEM/issues) and our [ongoing projects](https://github.com/SysBioChalmers/yeast-GEM/projects): Anything tagged with "help wanted" is open to whoever wants to implement it! -Here's how to set up yeast-GEM for local development to contribute smaller features or changes that you can implement yourself: +Here is how to set up yeast-GEM for local development to contribute smaller features or changes that you can implement yourself: -1. First of all, make sure that you have all [requirements](https://github.com/SysBioChalmers/yeast-GEM#required-software---contributor) for contributing to yeast-GEM. Note that COBRA and RAVEN should be cloned in your computer and not just downloaded. +1. First of all, make sure that you have all [requirements](https://github.com/SysBioChalmers/yeast-GEM#developer) for contributing to yeast-GEM. 2. Fork the yeast-GEM repository on GitHub (go to https://github.com/SysBioChalmers/yeast-GEM & click on the upper right corner). @@ -53,15 +53,13 @@ Here's how to set up yeast-GEM for local development to contribute smaller featu ``` 6. Now you can make your changes locally! - * Always make your changes in Matlab and never directly editing the model files. For loading the model use `loadYeastModel.m`, and for saving the model use `saveYeastModel.m`. The latter will ensure all 3 versions of the model (`.xml`, `.yml` & `.txt`) get updated in the same way. - * If your changes are minor (e.g. a single chemical formula you wish to correct), you can do it directly from the command line. - * If your changes are not so small and require several steps, create a script that loads the model, reads data (if applicable), changes the model accordingly, and saves the model back. - * Each script should start with a commented section describing the script, explaining the parameters, and indicating your name and the date it was written. Existing functions can clarify what style should be used. + * Always make your changes in MATLAB and never directly editing the model files. For loading the model use `loadYeastModel.m`, and for saving the model use `saveYeastModel.m`. The latter will ensure all 3 versions of the model (`.xml`, `.yml` & `.txt`) get updated in the same way. + * Curations to the model are consolidated in scripts that can convert a model from one yeast-GEM release (=version) to the next. Therefore, use the `/code/modelCuration/TEMPLATEcuration.m` file, or contribute directly to an existing `v$VERSION.m` script, where `$VERSION` matches the most recent yeast-GEM release. If the most recent release is 8.6.0, there will be a `/code/modelCuration/v8_6_0.m` script that consolidates curations to be applied to release 8.6.0. + * See the `TEMPLATEcuration.m` script with more description on how to use this file. Look at previous curations files (e.g. `v8_6_0.m`) to get an idea of how this works. * As much as possible follow the model conventions: - - For new metabolites and/or reactions, please use `/code/otherChanges/getNewIndex.m` for obtaining new ids. - For metabolite and/or reaction names, please avoid any unconventional characters (e.g. Greek letters). - For new genes, please use as id the [systematic names from SGD](http://seq.yeastgenome.org/help/community/nomenclature-conventions). - * Store scripts in the appropriate folder in `/code` and data (as `.tsv` files) in the appropriate folder in `/data`. If you think no folder is adequate for your script/data, feel free to create your own folder. Note that binary data such as `.mat` structures or `.xls` tables cannot be stored in the repo (as they cannot be version-controlled, and they increment too much the size of the repo). + * Store generic scripts in the appropriate folder in `/code` and data (as `.tsv` files) in the appropriate folder in `/data`. If a data file is just to apply one round of curation (for instance a table with selected gene associations to be corrected), it should be stored in the appropriate subfolder in `/code/modelCuration`. If you think no folder is adequate for your script/data, feel free to create your own folder. Note that binary data such as `.mat` structures or `.xls` tables cannot be stored in the repo (as they cannot be version-controlled, and they increment too much the size of the repo). * When you are done making changes, review locally your changes with `git diff` or any git client, to make sure you are modifying the model as you intended. 7. Commit your changes and push your branch to GitHub. diff --git a/.github/issue_template.md b/.github/issue_template.md index 937357a4..2365863d 100644 --- a/.github/issue_template.md +++ b/.github/issue_template.md @@ -1,23 +1,24 @@ ### Description of the issue: -*Try to be as clear as possible: Is it something wrong/missing in the model? Is it a simulation issue? PLEASE DELETE THIS LINE.* + #### Expected feature/value/output: -*How the reaction/metabolite/gene/simulation result should look (cite literature if needed). PLEASE DELETE THIS LINE.* + #### Current feature/value/output: -*How the reaction/metabolite/gene/simulation actually looks in the `main` branch. PLEASE DELETE THIS LINE.* + #### Reproducing these results: -*Please attach any code used below (if it's python code replace the word "matlab" with "python". PLEASE DELETE THIS LINE.* + ```matlab ``` **I hereby confirm that I have:** + - [ ] Tested my code with [all requirements](https://github.com/SysBioChalmers/yeast-GEM#required-software---user) for running the model -- [ ] Done this analysis in the `main` branch of the repository +- [ ] Done this analysis in the `develop` branch of the repository - [ ] Checked that a similar issue does not exist already - [ ] If needed, asked first in the [Gitter chat room](https://gitter.im/SysBioChalmers/yeast-GEM) about the issue diff --git a/.github/workflows/memote-history.yml b/.github/workflows/memote-history.yml index 331b4650..59baf6bb 100644 --- a/.github/workflows/memote-history.yml +++ b/.github/workflows/memote-history.yml @@ -18,7 +18,7 @@ jobs: python-version: '3.9.7' - name: Install memote - run: pip install -r requirements/ci-requirements.txt + run: pip install -r code/requirements/ci-requirements.txt - name: Setup variables id: setup diff --git a/.github/workflows/memote-run.yml b/.github/workflows/memote-run.yml index fde84724..f75354e9 100644 --- a/.github/workflows/memote-run.yml +++ b/.github/workflows/memote-run.yml @@ -16,7 +16,7 @@ jobs: python-version: '3.9.7' - name: Install memote - run: pip install -r requirements/ci-requirements.txt + run: pip install -r code/requirements/ci-requirements.txt - name: Convert model run: | diff --git a/.github/workflows/memote_release.yml b/.github/workflows/memote_release.yml index f793f806..2af1eae9 100644 --- a/.github/workflows/memote_release.yml +++ b/.github/workflows/memote_release.yml @@ -26,7 +26,7 @@ jobs: python-version: '3.9.7' - name: Install memote - run: pip install -r requirements/requirements.txt + run: pip install -r code/requirements/requirements.txt - name: Memote run run: | diff --git a/.github/workflows/yaml-validation.yml b/.github/workflows/yaml-validation.yml index 43bc4d1c..8e74367d 100644 --- a/.github/workflows/yaml-validation.yml +++ b/.github/workflows/yaml-validation.yml @@ -35,5 +35,5 @@ jobs: - name: Import with cobrapy run: | - pip install -r requirements/ci-requirements.txt + pip install -r code/requirements/ci-requirements.txt python -c "import cobra ; cobra.io.load_yaml_model('model/yeast-GEM.yml')" diff --git a/.gitignore b/.gitignore index 444de254..50d5b288 100644 --- a/.gitignore +++ b/.gitignore @@ -35,6 +35,7 @@ .Trashes ehthumbs.db Thumbs.db +.idea # Matlab generated files # ########################## @@ -51,7 +52,10 @@ helpsearch*/ *.pyc *.env -# Non-complying tables # -######################## -*.xls +# Non-complying tables and files # +################################## +*.xls* *.tab +*.doc* +*.ppt* +*.bak diff --git a/README.md b/README.md index 476d1aa3..6acb1d3f 100644 --- a/README.md +++ b/README.md @@ -33,7 +33,7 @@ This repository contains the current consensus genome-scale metabolic model of _ | Taxonomy | Latest update | Version | Reactions | Metabolites | Genes | |:-------|:--------------|:------|:------|:----------|:-----| -| _Saccharomyces cerevisiae_ | 18-May-2022 | 8.6.0 | 4069 | 2749 | 1151 | +| _Saccharomyces cerevisiae_ | 15-Jun-2022 | develop | 4063 | 2744 | 1163 | # Installation & usage @@ -69,7 +69,7 @@ Please see the installation instructions for each software package. If you want to use any of the [provided](https://github.com/SysBioChalmers/yeast-GEM/tree/main/code) Python functions, you may create an environment with all requirements: ```bash - pip install -r requirements/requirements.txt # installs all dependencies + pip install -r code/requirements/requirements.txt # installs all dependencies touch .env # creates a .env file for locating the root ``` diff --git a/code/missingFields/addBiGGidentifiers.m b/code/deprecated/missingFields/addBiGGidentifiers.m similarity index 100% rename from code/missingFields/addBiGGidentifiers.m rename to code/deprecated/missingFields/addBiGGidentifiers.m diff --git a/code/missingFields/addGeneNames.m b/code/deprecated/missingFields/addGeneNames.m similarity index 100% rename from code/missingFields/addGeneNames.m rename to code/deprecated/missingFields/addGeneNames.m diff --git a/code/missingFields/changeRules.m b/code/deprecated/missingFields/changeRules.m similarity index 100% rename from code/missingFields/changeRules.m rename to code/deprecated/missingFields/changeRules.m diff --git a/code/missingFields/deleteRepeated.m b/code/deprecated/missingFields/deleteRepeated.m similarity index 100% rename from code/missingFields/deleteRepeated.m rename to code/deprecated/missingFields/deleteRepeated.m diff --git a/code/missingFields/findInDB.m b/code/deprecated/missingFields/findInDB.m similarity index 100% rename from code/missingFields/findInDB.m rename to code/deprecated/missingFields/findInDB.m diff --git a/code/missingFields/findSubSystem.m b/code/deprecated/missingFields/findSubSystem.m similarity index 100% rename from code/missingFields/findSubSystem.m rename to code/deprecated/missingFields/findSubSystem.m diff --git a/code/missingFields/getAllPath.m b/code/deprecated/missingFields/getAllPath.m similarity index 100% rename from code/missingFields/getAllPath.m rename to code/deprecated/missingFields/getAllPath.m diff --git a/code/missingFields/getMissingFields.m b/code/deprecated/missingFields/getMissingFields.m similarity index 100% rename from code/missingFields/getMissingFields.m rename to code/deprecated/missingFields/getMissingFields.m diff --git a/code/modelCuration/MissingTransDeadEnd.m b/code/deprecated/modelCuration/MissingTransDeadEnd.m similarity index 100% rename from code/modelCuration/MissingTransDeadEnd.m rename to code/deprecated/modelCuration/MissingTransDeadEnd.m diff --git a/code/modelCuration/SubstrateUsage.m b/code/deprecated/modelCuration/SubstrateUsage.m similarity index 100% rename from code/modelCuration/SubstrateUsage.m rename to code/deprecated/modelCuration/SubstrateUsage.m diff --git a/code/modelCuration/UpdateDBnewRxn.m b/code/deprecated/modelCuration/UpdateDBnewRxn.m similarity index 100% rename from code/modelCuration/UpdateDBnewRxn.m rename to code/deprecated/modelCuration/UpdateDBnewRxn.m diff --git a/code/modelCuration/addBiologRxnToGEM.m b/code/deprecated/modelCuration/addBiologRxnToGEM.m similarity index 100% rename from code/modelCuration/addBiologRxnToGEM.m rename to code/deprecated/modelCuration/addBiologRxnToGEM.m diff --git a/code/modelCuration/addBiomassUpdate.m b/code/deprecated/modelCuration/addBiomassUpdate.m similarity index 100% rename from code/modelCuration/addBiomassUpdate.m rename to code/deprecated/modelCuration/addBiomassUpdate.m diff --git a/code/modelCuration/addDBnewRxn.m b/code/deprecated/modelCuration/addDBnewRxn.m similarity index 100% rename from code/modelCuration/addDBnewRxn.m rename to code/deprecated/modelCuration/addDBnewRxn.m diff --git a/code/modelCuration/addFAEnewRxn.m b/code/deprecated/modelCuration/addFAEnewRxn.m similarity index 100% rename from code/modelCuration/addFAEnewRxn.m rename to code/deprecated/modelCuration/addFAEnewRxn.m diff --git a/code/modelCuration/addGapfillingRxnToGEM.m b/code/deprecated/modelCuration/addGapfillingRxnToGEM.m similarity index 100% rename from code/modelCuration/addGapfillingRxnToGEM.m rename to code/deprecated/modelCuration/addGapfillingRxnToGEM.m diff --git a/code/modelCuration/addMetabolomicsRxnToGEM.m b/code/deprecated/modelCuration/addMetabolomicsRxnToGEM.m similarity index 100% rename from code/modelCuration/addMetabolomicsRxnToGEM.m rename to code/deprecated/modelCuration/addMetabolomicsRxnToGEM.m diff --git a/code/deprecated/modelCuration/addRxnSubsystem.m b/code/deprecated/modelCuration/addRxnSubsystem.m new file mode 100644 index 00000000..41671a36 --- /dev/null +++ b/code/deprecated/modelCuration/addRxnSubsystem.m @@ -0,0 +1,30 @@ +% This Function is for adding new subsystem into model. +% Input: model, keggPathways.tsv. +% NOTE: Before run the codes below, the file should be manually editted. +% COBRA required. +% New subsystem should be in .tsv format. +%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% + +% Load model +cd .. +model = loadYeastModel; + +%newsubsystem: +fid = fopen('../data/modelCuration/v8_6_0/keggPathways.tsv'); +sub_data = textscan(fid,'%s %s %s','Delimiter','\t','HeaderLines',1); +id = sub_data{1}; +subSystems = sub_data{2}; +fclose(fid); +for i = 1:length(model.rxns) + if i <= length(id) + subIndex = find(strcmp(model.rxns, id(i))); + model.subSystems{subIndex, 1} = subSystems{i}; + else + model.subSystems{i, 1} = 'nan'; + end +end + +% Save model: +cd .. +saveYeastModel(model) +cd modelCuration diff --git a/code/modelCuration/addSULnewRxn.m b/code/deprecated/modelCuration/addSULnewRxn.m similarity index 100% rename from code/modelCuration/addSULnewRxn.m rename to code/deprecated/modelCuration/addSULnewRxn.m diff --git a/code/modelCuration/changerxn.m b/code/deprecated/modelCuration/changerxn.m similarity index 100% rename from code/modelCuration/changerxn.m rename to code/deprecated/modelCuration/changerxn.m diff --git a/code/modelCuration/changerxnDirection.m b/code/deprecated/modelCuration/changerxnDirection.m similarity index 100% rename from code/modelCuration/changerxnDirection.m rename to code/deprecated/modelCuration/changerxnDirection.m diff --git a/code/modelCuration/checkRxnBalance.m b/code/deprecated/modelCuration/checkRxnBalance.m similarity index 100% rename from code/modelCuration/checkRxnBalance.m rename to code/deprecated/modelCuration/checkRxnBalance.m diff --git a/code/modelCuration/checkSmatrixMNX.m b/code/deprecated/modelCuration/checkSmatrixMNX.m similarity index 100% rename from code/modelCuration/checkSmatrixMNX.m rename to code/deprecated/modelCuration/checkSmatrixMNX.m diff --git a/code/modelCuration/checkrxnDirection.m b/code/deprecated/modelCuration/checkrxnDirection.m similarity index 100% rename from code/modelCuration/checkrxnDirection.m rename to code/deprecated/modelCuration/checkrxnDirection.m diff --git a/code/modelCuration/curationsOnV8_4_2.m b/code/deprecated/modelCuration/curationsOnV8_4_2.m similarity index 100% rename from code/modelCuration/curationsOnV8_4_2.m rename to code/deprecated/modelCuration/curationsOnV8_4_2.m diff --git a/code/modelCuration/display_rxnMetInfo.m b/code/deprecated/modelCuration/display_rxnMetInfo.m similarity index 100% rename from code/modelCuration/display_rxnMetInfo.m rename to code/deprecated/modelCuration/display_rxnMetInfo.m diff --git a/code/modelCuration/downloadMNXdb.m b/code/deprecated/modelCuration/downloadMNXdb.m similarity index 100% rename from code/modelCuration/downloadMNXdb.m rename to code/deprecated/modelCuration/downloadMNXdb.m diff --git a/code/modelCuration/get_lnRevIdx.m b/code/deprecated/modelCuration/get_lnRevIdx.m similarity index 100% rename from code/modelCuration/get_lnRevIdx.m rename to code/deprecated/modelCuration/get_lnRevIdx.m diff --git a/code/modelCuration/mapKEGGID.m b/code/deprecated/modelCuration/mapKEGGID.m similarity index 100% rename from code/modelCuration/mapKEGGID.m rename to code/deprecated/modelCuration/mapKEGGID.m diff --git a/code/modelCuration/mapMNXMID.m b/code/deprecated/modelCuration/mapMNXMID.m similarity index 100% rename from code/modelCuration/mapMNXMID.m rename to code/deprecated/modelCuration/mapMNXMID.m diff --git a/code/modelCuration/modMetsandSmatrix.m b/code/deprecated/modelCuration/modMetsandSmatrix.m similarity index 100% rename from code/modelCuration/modMetsandSmatrix.m rename to code/deprecated/modelCuration/modMetsandSmatrix.m diff --git a/code/modelCuration/modifyID.m b/code/deprecated/modelCuration/modifyID.m similarity index 100% rename from code/modelCuration/modifyID.m rename to code/deprecated/modelCuration/modifyID.m diff --git a/code/modelCuration/updateMetaboliteAnnotation.m b/code/deprecated/modelCuration/updateMetaboliteAnnotation.m similarity index 100% rename from code/modelCuration/updateMetaboliteAnnotation.m rename to code/deprecated/modelCuration/updateMetaboliteAnnotation.m diff --git a/code/otherChanges/getNewIndex.m b/code/deprecated/otherChanges/getNewIndex.m similarity index 100% rename from code/otherChanges/getNewIndex.m rename to code/deprecated/otherChanges/getNewIndex.m diff --git a/code/getEarlierModelVersion.m b/code/getEarlierModelVersion.m index 147a85e6..b5fcb2a1 100644 --- a/code/getEarlierModelVersion.m +++ b/code/getEarlierModelVersion.m @@ -11,7 +11,7 @@ if any(regexp(version,'^\d+\.\d+\.\d+$')) % Tag is a version number tagpath=['git show refs/tags/v' version ':']; -elseif any(contains(tag,{'main','develop'})) +elseif any(contains(version,{'main','develop'})) tagpath=['git show ' version ':']; else error('version should be ''main'', ''develop'', or a specific release, e.g. ''8.1.0''') diff --git a/code/increaseVersion.m b/code/increaseVersion.m index 3e7580c6..a7b2ece9 100644 --- a/code/increaseVersion.m +++ b/code/increaseVersion.m @@ -12,7 +12,7 @@ function increaseVersion(bumpType) %Check if in main: [~,currentBranch] = system('git rev-parse --abbrev-ref HEAD'); -if ~strcmp(currentBranch,'main') +if ~strcmp(strtrim(currentBranch),'main') error('ERROR: not in main') end @@ -46,8 +46,48 @@ function increaseVersion(bumpType) end %Load model: +disp('Loading model file') model = importModel('../model/yeast-GEM.xml'); +%Run tests +cd modelTests +disp('Running gene essentiality analysis') +[new.accuracy,new.tp,new.tn,new.fn,new.fp] = essentialGenes(newModel); +disp('Run growth analysis') +new.R2=growth(newModel); +saveas(gcf,'../../growth.png'); + +copyfile('../README.md','backup.md') +fin = fopen('backup.md','r'); +fout = fopen('../README.md','w'); +searchStats1 = '^(- Accuracy\: )0\.\d+'; +searchStats2 = '^(- True positive genes\: )\d+'; +searchStats3 = '^(- True negative genes\: )\d+'; +searchStats4 = '^(- False positive genes\: )\d+'; +searchStats5 = '^(- False negative genes\: )\d+'; +newStats1 = ['$1' num2str(new.accuracy)]; +newStats2 = ['$1' num2str(numel(new.tp))]; +newStats3 = ['$1' num2str(numel(new.tn))]; +newStats4 = ['$1' num2str(numel(new.fp))]; +newStats5 = ['$1' num2str(numel(new.fn))]; + +searchStats6 = '^(- R2<\/sup>\: )0\.\d+'; +newStats6 = ['$1' num2str(new.R2)]; + +while ~feof(fin) + str = fgets(fin); + inline = regexprep(str,searchStats1,newStats1); + inline = regexprep(inline,searchStats2,newStats2); + inline = regexprep(inline,searchStats3,newStats3); + inline = regexprep(inline,searchStats4,newStats4); + inline = regexprep(inline,searchStats5,newStats5); + inline = regexprep(inline,searchStats6,newStats6); + inline = unicode2native(inline,'UTF-8'); + fwrite(fout,inline); +end +fclose('all'); +delete('backup.md'); + %Allow .mat & .xlsx storage: copyfile('../.gitignore','backup') fin = fopen('backup','r'); @@ -77,14 +117,14 @@ function increaseVersion(bumpType) if length(diff_i) == 3 switch diff_i{3} case 'model/yeast-GEM.xml' - %.xml file: 2 line2 should be added & 2 line2 should be deleted + %.xml file: 2 lines should be added & 2 lines should be deleted if eval([diff_i{1} ' > 2']) || eval([diff_i{2} ' > 2']) disp(['NOTE: File ' diff_i{3} ' is changing more than expected']) change = true; end case 'model/yeast-GEM.yml' - %.yml file: 1 line should be added & 1 line should be deleted - if eval([diff_i{1} ' > 1']) || eval([diff_i{2} ' > 1']) + %.yml file: 2 lines should be added & 2 lines should be deleted + if eval([diff_i{1} ' > 2']) || eval([diff_i{2} ' > 2']) disp(['NOTE: File ' diff_i{3} ' is changing more than expected']) change = true; end diff --git a/code/loadYeastModel.m b/code/loadYeastModel.m index 5d2ab9d3..b505ca97 100644 --- a/code/loadYeastModel.m +++ b/code/loadYeastModel.m @@ -36,4 +36,5 @@ model = ravenCobraWrapper(model); end end +disp('If there is only 1 warning and no errors, it can savely be ignored.') end diff --git a/code/missingFields/README.md b/code/missingFields/README.md index 5d76fe63..f6bf1cb1 100644 --- a/code/missingFields/README.md +++ b/code/missingFields/README.md @@ -1,5 +1,3 @@ -## Missing Fields +## Missing fields -Scripts for adding fields to the model. - -**NOTE:** These scripts are provided as documentation + eventual re-use for developers. They are NOT intended to be used by regular users. +Various scripts for adding and curating various annotation fields to the model, that are useful for model curation. These functions should be written in a generic format, so that they could be reused for future curations. diff --git a/code/modelCuration/README.md b/code/modelCuration/README.md index 5c6bd630..4f4a6db2 100644 --- a/code/modelCuration/README.md +++ b/code/modelCuration/README.md @@ -1,5 +1,9 @@ -## Model Curation +## Model curation Scripts for curating different parts of the model. -**NOTE:** These scripts are provided as documentation + eventual re-use for developers. They are NOT intended to be used by regular users. +Curations between each model release are gathered in consolidated curation scripts that are named after the model version that they are curation. E.g. v8_6_0.m includes updates that should be applied to model version 8.6.0 to result in the next model release. + +TEMPLATEcuration.m is the template script that should be used to generate a new consolidated curation script after a new model has just been released. + +In addition, this folder contains generic functions that are useful for model curation. These functions should be written in a generic format, so that they could be reused for future curations. diff --git a/code/modelCuration/TEMPLATEcuration.m b/code/modelCuration/TEMPLATEcuration.m new file mode 100644 index 00000000..cd155bd8 --- /dev/null +++ b/code/modelCuration/TEMPLATEcuration.m @@ -0,0 +1,64 @@ +%% TEMPLATE FOR SCRIPT THAT CONSOLIDATES CURATIONS THAT ARE MADE TO A MODEL +% RELEASE. EACH RELEASE (e.g. yeast-GEM v8.6.1) WILL HAVE ITS OWN SCRIPT WHERE +% CURATIONS TO THAT MODEL RELEASE ARE CONSOLIDATED, MATCHING A DEDICATED FOLDER +% WITH DATA IN code/modelCuration/. SEE EARLIER SCRIPTS AS EXAMPLE. AFTER A NEW +% RELEASE IS MADE ON GITHUB, COPY-PASTE THIS TEMPLATE, REMOVE THIS LEADING +% CAPITALIZED TEXT, AND REPLACE $VERSION WITH THE VERSION NUMBER OF THE RECENT +% YEAST-GEM RELEASE (e.g. $VERSION --> 8.6.1). + +% This scripts applies curations to be applied on yeast-GEM release $VERSION. +% Indicate which Issue/PR are addressed. If multiple curations are performed +% before a new release is made, just add the required code to this script. If +% more extensive coding is required, you can write a separate (generic) function +% that can be kept in the /code/modelCuration folder. Otherwise, try to use +% existing functions whenever possible. In particular /code/curateMetsRxnsGenes +% can do many types of curation. + +%% Load yeast-GEM $VERSION (requires local yeast-GEM git repository) +cd .. +model = getEarlierModelVersion('$VERSION'); +model.id='yeastGEM_develop'; +cd modelCuration + +%% Brief description of curation to be performed (PR #xxx) [include correct PR or Issue number] +% Potential longer description of curation to be performed. +% If any data files need to be loaded, keep these in the dedicated folder at +% data/modelCuration/v$VERSION + +% Example [DELETE WHEN NOT USED]: + +%% Curate gene association for transport rxns (PR #306) +% Add new genes +model = curateMetsRxnsGenes(model,'none','../../data/modelCuration/curationsOnV8_6_0/transRxnNewGPRGenes.tsv'); + +% Change GPR relations +fid = fopen('../../data/modelCuration/curationsOnV8_6_0/TransRxnNewGPR.tsv'); +changegpr = textscan(fid,'%q %q %q %q %q %q %q %q','Delimiter','\t','HeaderLines',1); +newGPR.ID = changegpr{1}; +newGPR.GPR = changegpr{2}; +fclose(fid); + +model=changeGrRules(model,newGPR.ID,newGPR.GPR); + +% Delete unused genes (if any) +model = deleteUnusedGenes(model); + +%% DO NOT CHANGE OR REMOVE THE CODE BELOW THIS LINE. +% Show some metrics: +cd ../modelTests +disp('Run gene essentiality analysis') +[new.accuracy,new.tp,new.tn,new.fn,new.fp] = essentialGenes(model); +fprintf('Genes in model: %d\n',numel(model.genes)); +fprintf('Gene essentiality accuracy: %.4f\n', new.accuracy); +fprintf('Gene essentiality TP: %d\n', numel(new.tp)); +fprintf('Gene essentiality TN: %d\n', numel(new.tn)); +fprintf('Gene essentiality FP: %d\n', numel(new.fp)); +fprintf('Gene essentiality FN: %d\n', numel(new.fn)); +fprintf('\nRun growth analysis\n') +R2=growth(model); +fprintf('R2 of growth prediction: %.4f\n', R2); + +% Save model: +cd .. +saveYeastModel(model) +cd modelCuration diff --git a/code/modelCuration/addDBNewGeneAnnotation.m b/code/modelCuration/addDBNewGeneAnnotation.m deleted file mode 100644 index c35b3ec9..00000000 --- a/code/modelCuration/addDBNewGeneAnnotation.m +++ /dev/null @@ -1,50 +0,0 @@ -%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% -% addDBNewGeneAnnotation -% Add changes from the database new anootation for new genes + manual curation on those changes -% Input: model, databasenewGPR.tsv,SGDgeneNames.tsv. -% As for the reference of new GPR, please find detailed information in: -% data/databases/DBnewGeneAnnotation.tsv -% NOTE: changeGeneAssociation.m is a function from cobra -%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% - -% Load model -cd .. -model = loadYeastModel; - -% Change GPR relations -fid = fopen('../data/modelCuration/databasenewGPR.tsv'); -changegpr = textscan(fid,'%s %s %s','Delimiter','\t','HeaderLines',1); -newGPR.ID = changegpr{1}; -newGPR.oldGPR = changegpr{2}; -newGPR.GPR = changegpr{3}; -fclose(fid); -for i = 1:length(newGPR.ID) - rxnIndex = find(strcmp(model.rxns, newGPR.ID(i))); - model = changeGeneAssociation(model, model.rxns{rxnIndex}, newGPR.GPR{i}); -end - -% Delete unused genes (if any) -model = removeUnusedGenes(model); - -% Add gene standard name for new genes -fid = fopen('../data/databases/SGDgeneNames.tsv'); -yeast_gene_annotation = textscan(fid,'%s %s','Delimiter','\t','HeaderLines',1); -fclose(fid); -for i = 1: length(model.genes) - geneIndex = strcmp(yeast_gene_annotation{1}, model.genes{i}); - if sum(geneIndex) == 1 && ~isempty(yeast_gene_annotation{2}{geneIndex}) - model.geneNames{i} = yeast_gene_annotation{2}{geneIndex}; - else - model.geneNames{i} = model.genes{i}; - end -end - -% Add protein name for genes -for i = 1:length(model.genes) - model.proteins{i} = strcat('COBRAProtein',num2str(i)); -end - -% Save model: -model = rmfield(model,'grRules'); -saveYeastModel(model) -cd modelCuration diff --git a/code/modelCuration/addTransNewGPR.m b/code/modelCuration/addTransNewGPR.m deleted file mode 100644 index 353660ec..00000000 --- a/code/modelCuration/addTransNewGPR.m +++ /dev/null @@ -1,49 +0,0 @@ -%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% -% addTransNewGPR -% Add changes from the database new anootation for new genes + manual curation on those changes -% Input: model, databasenewGPR.tsv,SGDgeneNames.tsv. -% As for the reference of new GPR, please find detailed information in: -% data/databases/DBnewGeneAnnotation.tsv -% NOTE: changeGeneAssociation.m is a function from cobra -%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% - -% Load model -cd .. -model = loadYeastModel; - -% Change GPR relations -fid = fopen('../data/modelCuration/TransRxnNewGPR.tsv'); -changegpr = textscan(fid,'%s %s','Delimiter','\t','HeaderLines',1); -newGPR.ID = changegpr{1}; -newGPR.GPR = changegpr{2}; -fclose(fid); -for i = 1:length(newGPR.ID) - rxnIndex = find(strcmp(model.rxns, newGPR.ID(i))); - model = changeGeneAssociation(model, model.rxns{rxnIndex}, newGPR.GPR{i}); -end - -% Delete unused genes (if any) -model = removeUnusedGenes(model); - -% Add gene standard name for new genes -fid = fopen('../data/databases/SGDgeneNames.tsv'); -yeast_gene_annotation = textscan(fid,'%s %s','Delimiter','\t','HeaderLines',1); -fclose(fid); -for i = 1: length(model.genes) - geneIndex = strcmp(yeast_gene_annotation{1}, model.genes{i}); - if sum(geneIndex) == 1 && ~isempty(yeast_gene_annotation{2}{geneIndex}) - model.geneNames{i} = yeast_gene_annotation{2}{geneIndex}; - else - model.geneNames{i} = model.genes{i}; - end -end - -% Add protein name for genes -for i = 1:length(model.genes) - model.proteins{i} = strcat('COBRAProtein',num2str(i)); -end - -% Save model: -model = rmfield(model,'grRules'); -saveYeastModel(model) -cd modelCuration diff --git a/code/curateMetsRxnsGenes.m b/code/modelCuration/curateMetsRxnsGenes.m similarity index 98% rename from code/curateMetsRxnsGenes.m rename to code/modelCuration/curateMetsRxnsGenes.m index fe25ab37..ee3b32a0 100644 --- a/code/curateMetsRxnsGenes.m +++ b/code/modelCuration/curateMetsRxnsGenes.m @@ -36,7 +36,18 @@ % Output: % newModel curated RAVEN model structure +if nargin==4 + error('Provide both a ''rxnsInfo'' and a ''rxnsCoeffs'' file') +end +if nargin<4 + rxnsInfo='none'; + rxnsCoeffs='none'; +end +if nargin<3 + genesInfo='none'; +end newModel=model; + %% Metabolites if ~strcmp(metsInfo,'none') fid = fopen(metsInfo); @@ -302,6 +313,9 @@ emptyMiriam = all(cellfun(@isempty,miriamValues),1); miriamName(emptyMiriam) = []; miriamValues(:,emptyMiriam) = []; +if ~isfield(newModel,[type 'Miriams']); + newModel.([type 'Miriams'])=cell(numel(newModel.([type 's'])),1); +end if ~isempty(miriamName) for i=1:numel(miriamName) newModel = editMiriam(newModel,type,modelIndex,miriamName{i},miriamValues(:,i),'replace'); diff --git a/code/modelCuration/v8_6_0.m b/code/modelCuration/v8_6_0.m new file mode 100644 index 00000000..5781b937 --- /dev/null +++ b/code/modelCuration/v8_6_0.m @@ -0,0 +1,107 @@ +% This scripts applies curations to be applied on yeast-GEM release 8.6.0. +% Indicate which Issue/PR are addressed + +%% Load yeast-GEM 8.6.0 (requires local yeast-GEM git repository) +cd .. +model = getEarlierModelVersion('8.6.0'); +model.id='yeastGEM_develop'; + +%% Curate complex annotation (PR #305) +% Add new genes +cd modelCuration +model = curateMetsRxnsGenes(model,'none','../../data/modelCuration/v8_6_0/complexAnnotationGenes.tsv'); + +% Add gene standard name for new genes +fid = fopen('../../data/modelCuration/v8_6_0/complexAnnotation.tsv'); +complexAnnot = textscan(fid,'%q %q %q %q %q %q %q','Delimiter','\t','HeaderLines',1); +fclose(fid); +newGPR.ID = complexAnnot{1}; +newGPR.GPR = complexAnnot{3}; +model=changeGrRules(model,newGPR.ID,newGPR.GPR); + +% Delete unused genes (if any) +model = deleteUnusedGenes(model); + +%% Curate gene association for transport rxns (PR #306) +% Add new genes +model = curateMetsRxnsGenes(model,'none','../../data/modelCuration/v8_6_0/transRxnNewGPRGenes.tsv'); + +% Change GPR relations +fid = fopen('../../data/modelCuration/v8_6_0/TransRxnNewGPR.tsv'); +changegpr = textscan(fid,'%q %q %q %q %q %q %q %q','Delimiter','\t','HeaderLines',1); +newGPR.ID = changegpr{1}; +newGPR.GPR = changegpr{2}; +fclose(fid); + +model=changeGrRules(model,newGPR.ID,newGPR.GPR); + +% Delete unused genes (if any) +model = deleteUnusedGenes(model); + +%% Add new gene associations from databases (PR #313) +% Add new genes +model = curateMetsRxnsGenes(model,'none','../../data/modelCuration/v8_6_0/newGPRsfromDBsGenes.tsv'); + +% Change GPR relations +fid = fopen('../../data/modelCuration/v8_6_0/newGPRsfromDBs.tsv'); +changegpr = textscan(fid,'%q %q %q %q %q %q %q %q','Delimiter','\t','HeaderLines',1); +newGPR.ID = changegpr{1}; +newGPR.GPR = changegpr{3}; +fclose(fid); + +model = changeGrRules(model,newGPR.ID,newGPR.GPR); + +% Finding putative gene associations highlighted duplicated reactions: +% r_4566 is duplicate of r_4232, just in reverse direction +model = setParam(model,'lb','r_4232',-1000); +model = setParam(model,'rev','r_4232',1); +model = removeReactions(model,'r_4566',true,true,true); + +% The following are duplicates, just in different compartment and with some +% different names for same metabolites (reactions were added based on +% metabolomics data, while isoleucine & valine biosynthesis is localized in +% the mitochondrion) +% r_4576 -> half-reaction of r_0096 +% r_4577 -> duplicate of r_0352 +% r_4578 -> duplicate of r_0096 +% r_4579 -> duplicate of r_0097 +% r_4580 -> duplicate of r_0096 +model = removeReactions(model,... + {'r_4576','r_4577','r_4578','r_4579','r_4580'},true,true,true); + +% Delete unused genes (if any) +model = deleteUnusedGenes(model); + +%% Define unique subsystems (Issue #11, PR #307) +fid = fopen('../../data/modelCuration/v8_6_0/uniqueSubsystems.tsv'); +fileInput = textscan(fid,'%q %q %q %q %q %q %q','Delimiter','\t','HeaderLines',1); +fclose(fid); +subsystem.rxn = fileInput{1}; +subsystem.sub = fileInput{5}; + +[a,b] = ismember(subsystem.rxn,model.rxns); +%Remove non-matching reactions +b(~a)=[]; subsystem.sub(~a)=''; +for i=1:numel(b) + model.subSystems{b(i),1}=subsystem.sub(i); +end + +%% DO NOT CHANGE OR REMOVE THE CODE BELOW THIS LINE. +% Show some metrics: +cd ../modelTests +% disp('Run gene essentiality analysis') +% [new.accuracy,new.tp,new.tn,new.fn,new.fp] = essentialGenes(model); +% fprintf('Genes in model: %d\n',numel(model.genes)); +% fprintf('Gene essentiality accuracy: %.4f\n', new.accuracy); +% fprintf('Gene essentiality TP: %d\n', numel(new.tp)); +% fprintf('Gene essentiality TN: %d\n', numel(new.tn)); +% fprintf('Gene essentiality FP: %d\n', numel(new.fp)); +% fprintf('Gene essentiality FN: %d\n', numel(new.fn)); +% fprintf('\nRun growth analysis\n') +% R2=growth(model); +% fprintf('R2 of growth prediction: %.4f\n', R2); + +% Save model: +cd .. +saveYeastModel(model) +cd modelCuration diff --git a/code/modelTests/README.md b/code/modelTests/README.md index a3d27c1b..e972b321 100644 --- a/code/modelTests/README.md +++ b/code/modelTests/README.md @@ -1,3 +1,3 @@ -## Model Tests +## Model tests Scripts for testing model simulations. diff --git a/code/modelTests/essentialGenes.m b/code/modelTests/essentialGenes.m index 01f743d8..8b8e4735 100644 --- a/code/modelTests/essentialGenes.m +++ b/code/modelTests/essentialGenes.m @@ -1,4 +1,4 @@ -function [accurancy,tp,tn,fn,fp] = essentialGenes +function [accuracy,tp,tn,fn,fp] = essentialGenes(model) % essentialGenes % Modify media + find essential genes in model. Adapted from: % https://doi.org/10.1371/journal.pcbi.1004530 @@ -12,11 +12,11 @@ % Usage: [accurancy,tp,tn,fn,fp] = essentialGenes % -initCobraToolbox -cd .. -model = loadYeastModel; -model = ravenCobraWrapper(model); -cd modelTests +if nargin<1; + cd .. + model = loadYeastModel; + cd modelTests +end ko_tol = 1e-6; %constraints from genotype: check the genotype of the strains used in deletion experiment @@ -41,7 +41,10 @@ exp_viable = intersect(exp_viable,verifiedORFs); %calculate the growth rate after the single gene deletion using the original model and update model -grRatio = singleGeneDeletion(model); +[genes, fluxes, originalGenes, details, grRatioMuts]=findGeneDeletions(model,'sgd','fba'); +grRatio=ones(1,numel(model.genes)); +grRatio(genes)=grRatioMuts; + mod_viable = model.genes(grRatio >= ko_tol); mod_viable = intersect(mod_viable,verifiedORFs); mod_inviable = model.genes(grRatio < ko_tol ); @@ -59,7 +62,7 @@ %compare the prediction performances of two models %prediction accuracy was used to evaluate the quality of model update in %each step -accurancy = (n_tp+n_tn)/(n_tp+n_tn+n_fn+n_fp); +accuracy = (n_tp+n_tn)/(n_tp+n_tn+n_fn+n_fp); sensitivity = (100*n_tp/(n_tp+n_fn)); specificity = (100*n_tn/(n_tn+n_fp)); positivePredictive = (100*n_tp/(n_tp+n_fp)); @@ -75,7 +78,7 @@ % start with a clean slate: set all exchange reactions to upper bound = % 1000 and lower bound = 0 (ie, unconstrained excretion, no uptake) - exchangeRxns = findExcRxns(model); + [~, exchangeRxns] = getExchangeRxns(model); model.lb(exchangeRxns) = 0; model.ub(exchangeRxns) = 1000; @@ -106,12 +109,9 @@ 'r_4600'; ... % Ca(2+) exchange 'r_2020' }; - constrainedUptakeRxnIndexes = findRxnIDs(model,constrainedUptake); - glucoseExchangeIndex = findRxnIDs(model,glucoseExchange); - unconstrainedUptakeRxnIndexes = findRxnIDs(model,unconstrainedUptake); - model.lb(constrainedUptakeRxnIndexes) = -0.5; - model.lb(glucoseExchangeIndex) = -20; - model.lb(unconstrainedUptakeRxnIndexes) = -1000; + model=setParam(model,'lb',constrainedUptake,-0.5); + model=setParam(model,'lb',glucoseExchange,-20); + model=setParam(model,'lb',unconstrainedUptake,-1000); end function genes = inviableORFs diff --git a/code/modelTests/findDuplicatedRxns.m b/code/modelTests/findDuplicatedRxns.m index 0fb0b1bb..825a01b9 100644 --- a/code/modelTests/findDuplicatedRxns.m +++ b/code/modelTests/findDuplicatedRxns.m @@ -12,13 +12,12 @@ function findDuplicatedRxns(model) for i = 1:length(model.rxns)-1 for j = i+1:length(model.rxns) if isequal(model.S(:,i),model.S(:,j)) || isequal(model.S(:,i),-model.S(:,j)) - printRxnFormula(model,model.rxns(i),true,true,true); + constructEquations(model,model.rxns(i)); disp(['Name: ' model.rxnNames{i} ' - GPR: ' model.grRules{i} ' - LB=' num2str(model.lb(i)) ' - UB=' num2str(model.ub(i))]) - printRxnFormula(model,model.rxns(j),true,true,true); + constructEquations(model,model.rxns(j)); disp(['Name: ' model.rxnNames{j} ' - GPR: ' model.grRules{j} ' - LB=' num2str(model.lb(j)) ' - UB=' num2str(model.ub(j))]) disp(" ") end end end - end diff --git a/code/modelTests/growth.m b/code/modelTests/growth.m index ba12218c..32e5cca5 100644 --- a/code/modelTests/growth.m +++ b/code/modelTests/growth.m @@ -1,6 +1,6 @@ -function growth(model_origin) +function R2 = growth(model_origin) % This is for growth test: Fig S4c for yeast8 paper -% here we use several chemostat data: 'N-limited aerboic' 'C-limited +% here we use several chemostat data: 'N-limited aerobic' 'C-limited % aerobic' 'C-limited anaerobic' 'N-limited anaerobic' % when simulating N-limited condition, protein content was rescaled, and % when simulate anaerobic condtion, heme NADH NADP NADPH NAD were rescaled @@ -54,8 +54,10 @@ function growth(model_origin) ylabel('In silico growth rate [1/h]','FontSize',14,'FontName','Helvetica') legend(b,'N-limited aerobic','C-limited aerobic','C-limited anaerobic','N-limited anaerobic','Location','northwest') meanerror = sum(([exp_data1(:,4);exp_data2(:,4);exp_data3(:,4);exp_data4(:,4)]-[mod_data1(:,4);mod_data2(:,4);mod_data3(:,4);mod_data4(:,4)]).^2)/32; -text(0.4,0.1,['meanerror:',num2str(meanerror*100),'%']) +text(0.25,0.1,['meanerror:',num2str(meanerror*100),'%']) hold off +R2=corrcoef([exp_data1(:,4);exp_data2(:,4);exp_data3(:,4);exp_data4(:,4)],[mod_data1(:,4);mod_data2(:,4);mod_data3(:,4);mod_data4(:,4)]); +R2=R2(2)^2; end %%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% @@ -92,7 +94,12 @@ function growth(model_origin) model_test = setParam(model_test,'obj',model_test.rxns(pos(4)),1); sol = solveLP(model_test,1); %Store relevant variables: - mod_data(i,:) = abs(sol.x(pos)'); - solresult(:,i) = sol.x; + try + mod_data(i,:) = abs(sol.x(pos)'); + solresult(:,i) = sol.x; + catch + mod_data(i,:) = 0; + solresult(:,i) = 0; + end end end diff --git a/code/otherChanges/README.md b/code/otherChanges/README.md index a7c690f0..1fcf76dc 100644 --- a/code/otherChanges/README.md +++ b/code/otherChanges/README.md @@ -1,3 +1,3 @@ -## Other Changes +## Other changes -Scripts for performing miscellaneous changes to the model. +Scripts for performing miscellaneous changes to the model, that users might want to perform on any model release. diff --git a/requirements/ci-requirements.in b/code/requirements/ci-requirements.in similarity index 100% rename from requirements/ci-requirements.in rename to code/requirements/ci-requirements.in diff --git a/requirements/ci-requirements.txt b/code/requirements/ci-requirements.txt similarity index 71% rename from requirements/ci-requirements.txt rename to code/requirements/ci-requirements.txt index e988b7cc..7ac4b8cd 100644 --- a/requirements/ci-requirements.txt +++ b/code/requirements/ci-requirements.txt @@ -1,44 +1,49 @@ # -# This file is autogenerated by pip-compile +# This file is autogenerated by pip-compile with python 3.9 # To update, run: # # pip-compile ci-requirements.in # alabaster==0.7.12 # via sphinx +anyio==3.6.1 + # via httpcore appdirs==1.4.4 # via cobra -arrow==1.0.3 +arrow==1.2.2 # via jinja2-time -attrs==20.3.0 +attrs==21.4.0 # via + # jsonlines # jsonschema # pytest -babel==2.9.1 +babel==2.10.3 # via sphinx binaryornot==0.4.4 # via cookiecutter -boto3==1.17.49 +boto3==1.24.10 # via tabulator -botocore==1.20.49 +botocore==1.27.10 # via # boto3 # s3transfer cached-property==1.5.2 # via tableschema -certifi==2020.12.5 +certifi==2022.6.15 # via + # httpcore # httpx # requests -cffi==1.14.5 +cffi==1.15.0 # via cryptography chardet==4.0.0 # via # binaryornot # datapackage - # requests # tabulator -click==7.1.2 +charset-normalizer==2.0.12 + # via requests +click==8.1.3 # via # click-configfile # click-default-group @@ -54,21 +59,19 @@ click-configfile==0.2.3 # via memote click-default-group==1.2.2 # via goodtables -click-log==0.3.2 +click-log==0.4.0 # via memote -cobra==0.22.1 +cobra==0.25.0 # via # -r ci-requirements.in # memote -colorama==0.4.4 - # via rich commonmark==0.9.1 # via rich -configparser==5.0.2 +configparser==5.2.0 # via click-configfile -cookiecutter==1.7.2 +cookiecutter==2.1.1 # via memote -cryptography==3.4.7 +cryptography==37.0.2 # via travis-encrypt datapackage==1.15.2 # via goodtables @@ -76,49 +79,52 @@ depinfo==1.7.0 # via # cobra # memote -diskcache==5.2.1 +diskcache==5.4.0 # via cobra -docutils==0.17 +docutils==0.18.1 # via # sphinx # statistics -et-xmlfile==1.0.1 +et-xmlfile==1.1.0 # via openpyxl future==0.18.2 # via # cobra # memote -gitdb==4.0.7 +gitdb==4.0.9 # via gitpython -gitpython==3.1.14 +gitpython==3.1.27 # via memote goodtables==2.5.4 # via memote -greenlet==1.0.0 +greenlet==1.1.2 # via sqlalchemy h11==0.12.0 # via httpcore -httpcore==0.12.3 +httpcore==0.15.0 # via httpx -httpx==0.17.1 +httpx==0.23.0 # via cobra -idna==2.10 +idna==3.3 # via + # anyio # requests # rfc3986 ijson==3.1.4 # via tabulator -imagesize==1.2.0 +imagesize==1.3.0 # via sphinx -importlib-resources==5.1.2 +importlib-metadata==4.11.4 + # via sphinx +importlib-resources==5.8.0 # via # cobra # memote iniconfig==1.1.1 # via pytest -isodate==0.6.0 +isodate==0.6.1 # via tableschema -jinja2==2.11.3 +jinja2==3.1.2 # via # cookiecutter # jinja2-time @@ -127,89 +133,87 @@ jinja2==2.11.3 # sphinx jinja2-time==0.2.0 # via cookiecutter -jmespath==0.10.0 +jmespath==1.0.0 # via # boto3 # botocore -jsonlines==2.0.0 +jsonlines==3.0.0 # via tabulator -jsonpointer==2.1 +jsonpointer==2.3 # via datapackage -jsonschema==3.2.0 +jsonschema==4.6.0 # via # datapackage # tableschema linear-tsv==1.1.0 # via tabulator -markupsafe==1.1.1 - # via - # cookiecutter - # jinja2 +markupsafe==2.1.1 + # via jinja2 memote==0.13.0 # via -r ci-requirements.in mpmath==1.2.1 # via sympy -numpy==1.20.2 +numpy==1.22.4 # via # cobra # pandas -numpydoc==1.1.0 +numpydoc==1.4.0 # via memote -openpyxl==3.0.7 +openpyxl==3.0.10 # via tabulator optlang==1.5.2 # via cobra -packaging==20.9 +packaging==21.3 # via # pytest # sphinx -pandas==1.2.3 +pandas==1.4.2 # via # cobra # memote -pluggy==0.13.1 +pluggy==1.0.0 # via pytest -poyo==0.5.0 - # via cookiecutter -py==1.10.0 +py==1.11.0 # via pytest -pycparser==2.20 +pycparser==2.21 # via cffi -pydantic==1.8.2 +pydantic==1.9.1 # via cobra -pygments==2.8.1 +pygments==2.12.0 # via # rich # sphinx -pylru==1.2.0 +pylru==1.2.1 # via memote -pyparsing==2.4.7 +pyparsing==3.0.9 # via packaging pyperclip==1.6.0 # via travis-encrypt -pyrsistent==0.17.3 +pyrsistent==0.18.1 # via jsonschema -pytest==6.2.3 +pytest==7.1.2 # via memote -python-dateutil==2.8.1 +python-dateutil==2.8.2 # via # arrow # botocore # pandas # tableschema -python-dotenv==0.19.0 +python-dotenv==0.20.0 # via -r ci-requirements.in -python-libsbml==5.19.0 +python-libsbml==5.19.5 # via cobra -python-slugify==4.0.1 +python-slugify==6.1.2 # via cookiecutter -pytz==2021.1 +pytz==2022.1 # via # babel # pandas -pyyaml==5.4.1 - # via travis-encrypt -requests==2.25.1 +pyyaml==6.0 + # via + # cookiecutter + # travis-encrypt +requests==2.28.0 # via # cookiecutter # datapackage @@ -219,71 +223,70 @@ requests==2.25.1 # tableschema # tabulator # travis-encrypt -rfc3986[idna2008]==1.4.0 +rfc3986[idna2008]==1.5.0 # via # httpx # tableschema -rich==10.7.0 +rich==12.4.4 # via cobra -ruamel.yaml==0.17.4 +ruamel-yaml==0.17.21 # via # cobra # memote -ruamel.yaml.clib==0.2.2 - # via ruamel.yaml -s3transfer==0.3.6 +ruamel-yaml-clib==0.2.6 + # via ruamel-yaml +s3transfer==0.6.0 # via boto3 -simpleeval==0.9.10 +simpleeval==0.9.12 # via goodtables -six==1.15.0 +six==1.16.0 # via # click-configfile - # cookiecutter # datapackage # goodtables # isodate - # jsonschema # linear-tsv # memote # optlang # python-dateutil # tableschema # tabulator -smmap==4.0.0 +smmap==5.0.0 # via gitdb sniffio==1.2.0 # via + # anyio # httpcore # httpx -snowballstemmer==2.1.0 +snowballstemmer==2.2.0 # via sphinx -sphinx==3.5.3 +sphinx==5.0.1 # via numpydoc sphinxcontrib-applehelp==1.0.2 # via sphinx sphinxcontrib-devhelp==1.0.2 # via sphinx -sphinxcontrib-htmlhelp==1.0.3 +sphinxcontrib-htmlhelp==2.0.0 # via sphinx sphinxcontrib-jsmath==1.0.1 # via sphinx sphinxcontrib-qthelp==1.0.3 # via sphinx -sphinxcontrib-serializinghtml==1.1.4 +sphinxcontrib-serializinghtml==1.1.5 # via sphinx -sqlalchemy==1.4.7 +sqlalchemy==1.4.37 # via # memote # tabulator statistics==1.0.3.5 # via goodtables -swiglpk==5.0.3 +swiglpk==5.0.5 # via # cobra # optlang -symengine==0.8.1 +symengine==0.9.2 # via -r ci-requirements.in -sympy==1.8 +sympy==1.10.1 # via # memote # optlang @@ -298,23 +301,24 @@ tabulator==1.53.5 # tableschema text-unidecode==1.3 # via python-slugify -toml==0.10.2 +tomli==2.0.1 # via pytest travis-encrypt==1.1.2 # via memote -typing-extensions==3.7.4.3 +typing-extensions==4.2.0 # via pydantic unicodecsv==0.14.1 # via # datapackage # tableschema # tabulator -urllib3==1.26.5 +urllib3==1.26.9 # via # botocore # requests xlrd==2.0.1 # via tabulator - -# The following packages are considered to be unsafe in a requirements file: -# setuptools +zipp==3.8.0 + # via + # importlib-metadata + # importlib-resources diff --git a/requirements/dev-requirements.in b/code/requirements/dev-requirements.in similarity index 100% rename from requirements/dev-requirements.in rename to code/requirements/dev-requirements.in diff --git a/requirements/dev-requirements.txt b/code/requirements/dev-requirements.txt similarity index 95% rename from requirements/dev-requirements.txt rename to code/requirements/dev-requirements.txt index eeb2a265..556d04cf 100644 --- a/requirements/dev-requirements.txt +++ b/code/requirements/dev-requirements.txt @@ -38,7 +38,7 @@ attrs==21.4.0 # jsonlines # jsonschema # pytest -babel==2.10.1 +babel==2.10.3 # via # -r requirements.txt # sphinx @@ -58,11 +58,11 @@ bleach==5.0.0 # via # -r requirements.txt # nbconvert -boto3==1.23.2 +boto3==1.24.10 # via # -r requirements.txt # tabulator -botocore==1.26.2 +botocore==1.27.10 # via # -r requirements.txt # boto3 @@ -71,7 +71,7 @@ cached-property==1.5.2 # via # -r requirements.txt # tableschema -certifi==2021.10.8 +certifi==2022.6.15 # via # -r requirements.txt # httpcore @@ -91,7 +91,6 @@ chardet==4.0.0 charset-normalizer==2.0.12 # via # -r requirements.txt - # httpx # requests click==8.1.3 # via @@ -131,7 +130,7 @@ configparser==5.2.0 # via # -r requirements.txt # click-configfile -cookiecutter==1.7.3 +cookiecutter==2.1.1 # via # -r requirements.txt # memote @@ -164,7 +163,7 @@ diskcache==5.4.0 # via # -r requirements.txt # cobra -docutils==0.17.1 +docutils==0.18.1 # via # -r requirements.txt # sphinx @@ -211,11 +210,11 @@ h11==0.12.0 # via # -r requirements.txt # httpcore -httpcore==0.14.7 +httpcore==0.15.0 # via # -r requirements.txt # httpx -httpx==0.22.0 +httpx==0.23.0 # via # -r requirements.txt # cobra @@ -233,11 +232,11 @@ imagesize==1.3.0 # via # -r requirements.txt # sphinx -importlib-metadata==4.11.3 +importlib-metadata==4.11.4 # via # -r requirements.txt # sphinx -importlib-resources==5.7.1 +importlib-resources==5.8.0 # via # -r requirements.txt # cobra @@ -246,11 +245,11 @@ iniconfig==1.1.1 # via # -r requirements.txt # pytest -ipykernel==6.13.0 +ipykernel==6.15.0 # via # -r requirements.txt # notebook -ipython==8.3.0 +ipython==8.4.0 # via # -r requirements.txt # ipykernel @@ -293,13 +292,13 @@ jsonpointer==2.3 # via # -r requirements.txt # datapackage -jsonschema==4.5.1 +jsonschema==4.6.0 # via # -r requirements.txt # datapackage # nbformat # tableschema -jupyter-client==7.3.1 +jupyter-client==7.3.4 # via # -r requirements.txt # ipykernel @@ -340,7 +339,7 @@ mpmath==1.2.1 # via # -r requirements.txt # sympy -nbclient==0.6.3 +nbclient==0.6.4 # via # -r requirements.txt # nbconvert @@ -361,18 +360,18 @@ nest-asyncio==1.5.5 # jupyter-client # nbclient # notebook -notebook==6.4.11 +notebook==6.4.12 # via -r requirements.txt -numpy==1.22.3 +numpy==1.22.4 # via # -r requirements.txt # cobra # pandas -numpydoc==1.3.1 +numpydoc==1.4.0 # via # -r requirements.txt # memote -openpyxl==3.0.9 +openpyxl==3.0.10 # via # -r requirements.txt # tabulator @@ -410,16 +409,12 @@ pickleshare==0.7.5 # via # -r requirements.txt # ipython -pip-tools==6.6.1 +pip-tools==6.6.2 # via -r dev-requirements.in pluggy==1.0.0 # via # -r requirements.txt # pytest -poyo==0.5.0 - # via - # -r requirements.txt - # cookiecutter prometheus-client==0.14.1 # via # -r requirements.txt @@ -428,7 +423,7 @@ prompt-toolkit==3.0.29 # via # -r requirements.txt # ipython -psutil==5.9.0 +psutil==5.9.1 # via # -r requirements.txt # ipykernel @@ -449,7 +444,7 @@ pycparser==2.21 # via # -r requirements.txt # cffi -pydantic==1.9.0 +pydantic==1.9.1 # via # -r requirements.txt # cobra @@ -506,13 +501,15 @@ pytz==2022.1 pyyaml==6.0 # via # -r requirements.txt + # cookiecutter # travis-encrypt -pyzmq==22.3.0 +pyzmq==23.1.0 # via # -r requirements.txt + # ipykernel # jupyter-client # notebook -requests==2.27.1 +requests==2.28.0 # via # -r requirements.txt # cookiecutter @@ -528,7 +525,7 @@ rfc3986[idna2008]==1.5.0 # -r requirements.txt # httpx # tableschema -rich==12.4.1 +rich==12.4.4 # via # -r requirements.txt # cobra @@ -541,7 +538,7 @@ ruamel-yaml-clib==0.2.6 # via # -r requirements.txt # ruamel-yaml -s3transfer==0.5.2 +s3transfer==0.6.0 # via # -r requirements.txt # boto3 @@ -559,7 +556,6 @@ six==1.16.0 # asttokens # bleach # click-configfile - # cookiecutter # datapackage # goodtables # isodate @@ -587,7 +583,7 @@ soupsieve==2.3.2.post1 # via # -r requirements.txt # beautifulsoup4 -sphinx==4.5.0 +sphinx==5.0.1 # via # -r requirements.txt # numpydoc @@ -615,12 +611,12 @@ sphinxcontrib-serializinghtml==1.1.5 # via # -r requirements.txt # sphinx -sqlalchemy==1.4.36 +sqlalchemy==1.4.37 # via # -r requirements.txt # memote # tabulator -stack-data==0.2.0 +stack-data==0.3.0 # via # -r requirements.txt # ipython @@ -675,7 +671,7 @@ tornado==6.1 # jupyter-client # notebook # terminado -traitlets==5.2.1.post0 +traitlets==5.3.0 # via # -r requirements.txt # ipykernel diff --git a/requirements/requirements.in b/code/requirements/requirements.in similarity index 100% rename from requirements/requirements.in rename to code/requirements/requirements.in diff --git a/requirements/requirements.txt b/code/requirements/requirements.txt similarity index 92% rename from requirements/requirements.txt rename to code/requirements/requirements.txt index c1352e03..acb3519a 100644 --- a/requirements/requirements.txt +++ b/code/requirements/requirements.txt @@ -23,7 +23,7 @@ attrs==21.4.0 # jsonlines # jsonschema # pytest -babel==2.10.1 +babel==2.10.3 # via sphinx backcall==0.2.0 # via ipython @@ -33,15 +33,15 @@ binaryornot==0.4.4 # via cookiecutter bleach==5.0.0 # via nbconvert -boto3==1.23.2 +boto3==1.24.10 # via tabulator -botocore==1.26.2 +botocore==1.27.10 # via # boto3 # s3transfer cached-property==1.5.2 # via tableschema -certifi==2021.10.8 +certifi==2022.6.15 # via # httpcore # httpx @@ -56,9 +56,7 @@ chardet==4.0.0 # datapackage # tabulator charset-normalizer==2.0.12 - # via - # httpx - # requests + # via requests click==8.1.3 # via # click-configfile @@ -85,7 +83,7 @@ commonmark==0.9.1 # via rich configparser==5.2.0 # via click-configfile -cookiecutter==1.7.3 +cookiecutter==2.1.1 # via memote cryptography==37.0.2 # via travis-encrypt @@ -103,7 +101,7 @@ depinfo==1.7.0 # memote diskcache==5.4.0 # via cobra -docutils==0.17.1 +docutils==0.18.1 # via # sphinx # statistics @@ -131,9 +129,9 @@ greenlet==1.1.2 # via sqlalchemy h11==0.12.0 # via httpcore -httpcore==0.14.7 +httpcore==0.15.0 # via httpx -httpx==0.22.0 +httpx==0.23.0 # via cobra idna==3.3 # via @@ -144,17 +142,17 @@ ijson==3.1.4 # via tabulator imagesize==1.3.0 # via sphinx -importlib-metadata==4.11.3 +importlib-metadata==4.11.4 # via sphinx -importlib-resources==5.7.1 +importlib-resources==5.8.0 # via # cobra # memote iniconfig==1.1.1 # via pytest -ipykernel==6.13.0 +ipykernel==6.15.0 # via notebook -ipython==8.3.0 +ipython==8.4.0 # via ipykernel ipython-genutils==0.2.0 # via notebook @@ -181,12 +179,12 @@ jsonlines==3.0.0 # via tabulator jsonpointer==2.3 # via datapackage -jsonschema==4.5.1 +jsonschema==4.6.0 # via # datapackage # nbformat # tableschema -jupyter-client==7.3.1 +jupyter-client==7.3.4 # via # ipykernel # nbclient @@ -215,7 +213,7 @@ mistune==0.8.4 # via nbconvert mpmath==1.2.1 # via sympy -nbclient==0.6.3 +nbclient==0.6.4 # via nbconvert nbconvert==6.5.0 # via notebook @@ -230,15 +228,15 @@ nest-asyncio==1.5.5 # jupyter-client # nbclient # notebook -notebook==6.4.11 +notebook==6.4.12 # via -r requirements.in -numpy==1.22.3 +numpy==1.22.4 # via # cobra # pandas -numpydoc==1.3.1 +numpydoc==1.4.0 # via memote -openpyxl==3.0.9 +openpyxl==3.0.10 # via tabulator optlang==1.5.2 # via cobra @@ -262,13 +260,11 @@ pickleshare==0.7.5 # via ipython pluggy==1.0.0 # via pytest -poyo==0.5.0 - # via cookiecutter prometheus-client==0.14.1 # via notebook prompt-toolkit==3.0.29 # via ipython -psutil==5.9.0 +psutil==5.9.1 # via ipykernel ptyprocess==0.7.0 # via @@ -280,7 +276,7 @@ py==1.11.0 # via pytest pycparser==2.21 # via cffi -pydantic==1.9.0 +pydantic==1.9.1 # via cobra pygments==2.12.0 # via @@ -316,12 +312,15 @@ pytz==2022.1 # babel # pandas pyyaml==6.0 - # via travis-encrypt -pyzmq==22.3.0 # via + # cookiecutter + # travis-encrypt +pyzmq==23.1.0 + # via + # ipykernel # jupyter-client # notebook -requests==2.27.1 +requests==2.28.0 # via # cookiecutter # datapackage @@ -335,7 +334,7 @@ rfc3986[idna2008]==1.5.0 # via # httpx # tableschema -rich==12.4.1 +rich==12.4.4 # via cobra ruamel-yaml==0.17.21 # via @@ -343,7 +342,7 @@ ruamel-yaml==0.17.21 # memote ruamel-yaml-clib==0.2.6 # via ruamel-yaml -s3transfer==0.5.2 +s3transfer==0.6.0 # via boto3 send2trash==1.8.0 # via notebook @@ -354,7 +353,6 @@ six==1.16.0 # asttokens # bleach # click-configfile - # cookiecutter # datapackage # goodtables # isodate @@ -375,7 +373,7 @@ snowballstemmer==2.2.0 # via sphinx soupsieve==2.3.2.post1 # via beautifulsoup4 -sphinx==4.5.0 +sphinx==5.0.1 # via numpydoc sphinxcontrib-applehelp==1.0.2 # via sphinx @@ -389,11 +387,11 @@ sphinxcontrib-qthelp==1.0.3 # via sphinx sphinxcontrib-serializinghtml==1.1.5 # via sphinx -sqlalchemy==1.4.36 +sqlalchemy==1.4.37 # via # memote # tabulator -stack-data==0.2.0 +stack-data==0.3.0 # via ipython statistics==1.0.3.5 # via goodtables @@ -430,7 +428,7 @@ tornado==6.1 # jupyter-client # notebook # terminado -traitlets==5.2.1.post0 +traitlets==5.3.0 # via # ipykernel # ipython diff --git a/data/databases/README.md b/data/databases/README.md index 15ffae55..10dd14d7 100644 --- a/data/databases/README.md +++ b/data/databases/README.md @@ -1,3 +1,5 @@ ## Databases -Yeast data from different databases (KEGG, SGD, swissprot, etc). +Yeast data from different databases (KEGG, SGD, swissprot, etc), or other data that could be repeatedly used. + +Data files that are only used once, for instance containing a list of new reactions to be added to the model, should instead be stored in a dedicated folder in ../modelCuration. diff --git a/data/databases/Yeast_complex_portal_2022.tsv b/data/databases/Yeast_complex_portal_2022.tsv new file mode 100644 index 00000000..ef40d74f --- /dev/null +++ b/data/databases/Yeast_complex_portal_2022.tsv @@ -0,0 +1,617 @@ +#Complex ac Recommended name Aliases for complex Taxonomy identifier Identifiers (and stoichiometry) of molecules in complex Evidence Code Experimental evidence Go Annotations Cross references Description Complex properties Complex assembly Ligand Disease Agonist Antagonist Comment Source Expanded participant list +CPX-15 CST complex - 559292 P32797(0)|P38960(0)|Q07921(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:1990879(CST complex)|GO:0000781(chromosome, telomeric region)|GO:0016233(telomere capping)|GO:0051974(negative regulation of telomerase activity)|GO:0032210(regulation of telomere maintenance via telomerase)|GO:0043047(single-stranded telomeric DNA binding) complex portal:CPX-15(complex-primary)|pubmed:22879408(see-also)|pubmed:17293872(see-also)|pubmed:23851344(see-also) RPA-like (replication protein A) complex, that has high affinity for telomeric ssDNA. The complex is assembled during late S-G2 and is involved in capping, and thus protecting, single stranded telomeric DNA and preventing chromosomal damage by inhibiting telomerase activity. Plays a role in the regulation of the synthesis of C strand via its interaction with polymerase alpha primase. Stn1 interacts with the other 2 subunits, forming a bridge between them. Stn1 and Ten1 can form a heterodimer and Cdc13 on its own, has the ability to form a homodimer. - - - - - - psi-mi:"-"(Saccharomyces Genome Database) P32797(0)|P38960(0)|Q07921(0) +CPX-21 Replication protein A complex - 559292 P22336(1)|P26754(1)|P26755(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-15875540 GO:0005662(DNA replication factor A complex)|GO:0003697(single-stranded DNA binding)|GO:0006260(DNA replication)|GO:0006281(DNA repair)|GO:0006312(mitotic recombination)|GO:0000723(telomere maintenance) pubmed:15102447(see-also)|pubmed:9242902(see-also)|complex portal:CPX-21(complex-primary)|wwpdb:6I52(identity)|emdb:EMD-4410(identity)|pubmed:30575763(see-also) Single-stranded DNA binding protein complex involved in all processes that involve single-stranded (ss)DNA by binding to and protecting exposed ssDNA from nucleases. Forms a physical platform to recruit other factors to the DNA including those involved in DNA damage signaling, DNA repair, and DNA replication. RPA protects against inappropriate telomere recombination, and upon telomere uncapping, prevents cell proliferation by a checkpoint-independent pathway. RPA prevents degradation of ssDNA and prevents formation of secondary structures. RPA can associate with ssDNA in different modalities; a low affinity mode which binds 8–12 nucleotides (nts) and a high-affinity compact mode involving four major DBDs from RFA1 and RFA2 that bends a 28 nts ssDNA tract into a horse-shoe shaped configuration. RFA33 is thought to provide a structural role within the complex. Multiple RPAs may assemble on ssDNA and form higher order assemblies that modulate its function. Heterotrimer - - - - - psi-mi:"-"(Saccharomyces Genome Database) P22336(1)|P26754(1)|P26755(1) +CPX-23 U1 small nuclear ribonucleoprotein complex - 559292 P32605(0)|P33203(0)|P39682(0)|P40018(0)|P40204(0)|P43321(0)|P53207(0)|P54999(0)|Q00539(0)|Q00916(0)|Q02260(0)|Q03776(0)|Q03782(0)|Q05900(0)|Q06217(0)|Q07508(0)|Q12330(0)|URS000012D749_559292(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0030627(pre-mRNA 5'-splice site binding)|GO:0005685(U1 snRNP)|GO:0000395(mRNA 5'-splice site recognition)|GO:0005634(nucleus)|GO:0005681(spliceosomal complex) pubmed:19941820(see-also)|pubmed:22762203(see-also)|complex portal:CPX-23(complex-primary) Non-coding RNA containing complex that is involved in mRNA splicing. U1 snRNP binds to the 5-prime splice site contributing to the formation of the Commitment complex (CPX-1418) during spliceosome assembly. The spliceosome is a highly dynamic structure, assembled by sequential binding and release of the small nuclear RNAs and protein factors which removes intronic sequence from pre-mRNA. After assembly of the precatalytic spliceosome, U1 is released during the activation of the spliceosome. SMB1, SMD1, SMD2, SMD3, SME1, SMX3 and SMX2 assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. - - - - - - psi-mi:"-"(Saccharomyces Genome Database) P32605(0)|P33203(0)|P39682(0)|P40018(0)|P40204(0)|P43321(0)|P53207(0)|P54999(0)|Q00539(0)|Q00916(0)|Q02260(0)|Q03776(0)|Q03782(0)|Q05900(0)|Q06217(0)|Q07508(0)|Q12330(0) +CPX-24 U6 small nuclear ribonucleoprotein complex U6 snRNP 559292 P38203(0)|P40070(0)|P40089(0)|P47093(0)|P49960(0)|P53905(0)|P57743(0)|Q06406(0)|URS00006184A9_559292(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0005688(U6 snRNP)|GO:0000398(mRNA splicing, via spliceosome)|GO:0005681(spliceosomal complex)|GO:0005634(nucleus) wwpdb:4M77(subset)|wwpdb:4M78(subset)|wwpdb:4C92(subset)|wwpdb:4M7D(subset)|complex portal:CPX-24(complex-primary)|pubmed:22762203(see-also)|pubmed:19941820(see-also)|pubmed:11804584(see-also) Non-coding RNA containing complex that is involved in mRNA splicing. Instead of the Sm ring found in the other spliceosomal snRNPs, it contains an Sm-like ring. The spliceosome is a highly dynamic structure, assembled by sequential binding and release of the small nuclear RNAs and protein factors which removes intronic sequence from pre-mRNA. U6 is part of the activated spliceosome and is involved in the first transestherification step of splicing. After splicing is complete, the spliceosome disassembles and free U6 snRNP forms. It then reassociates with U4 (CPX-31) to form U4/U6 snRNP (CPX-32). - - - - - - - psi-mi:"-"(Saccharomyces Genome Database) P38203(0)|P40070(0)|P40089(0)|P47093(0)|P49960(0)|P53905(0)|P57743(0)|Q06406(0) +CPX-25 U4/U6.U5 tri-small nuclear ribonucleoprotein complex U4/U6 x U5 snRNP complex|U4/U6.U5 tri-small nuclear ribonucleoprotein complex 559292 P19735(0)|P20053(0)|P23394(0)|P32639(0)|P33334(0)|P36048(0)|P38203(0)|P38282(0)|P39990(0)|P40018(0)|P40070(0)|P40089(0)|P40204(0)|P43321(0)|P43589(0)|P47093(0)|P49704(0)|P53905(0)|P54999(0)|P57743(0)|Q00723(0)|Q02260(0)|Q03338(0)|Q06217(0)|Q06406(0)|Q06819(0)|Q12330(0)|Q12368(0)|Q12420(0)|URS00001143F5_559292(0)|URS0000514318_559292(0)|URS000053F313_559292(0)|URS00006184A9_559292(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0046540(U4/U6 x U5 tri-snRNP complex)|GO:0005634(nucleus)|GO:0000398(mRNA splicing, via spliceosome)|GO:0005681(spliceosomal complex) pubmed:22762203(see-also)|pubmed:19941820(see-also)|pubmed:11804584(see-also)|complex portal:CPX-25(complex-primary) Non-coding RNA containing complex that is involved in mRNA splicing. The U4/U6 x U5 tri-snRNP complex binds to the pre-spliceosome complex to form the pre-activation complex. The spliceosome is a highly dynamic structure, assembled by sequential binding and release of the small nuclear RNAs and protein factors which removes intronic sequence from pre-mRNA. - - - - - - - psi-mi:"-"(Saccharomyces Genome Database) P19735(0)|P20053(0)|P23394(0)|P32639(0)|P33334(0)|P36048(0)|P38203(0)|P38282(0)|P39990(0)|P40018(0)|P40070(0)|P40089(0)|P40204(0)|P43321(0)|P43589(0)|P47093(0)|P49704(0)|P53905(0)|P54999(0)|P57743(0)|Q00723(0)|Q02260(0)|Q03338(0)|Q06217(0)|Q06406(0)|Q06819(0)|Q12330(0)|Q12368(0)|Q12420(0) +CPX-26 U2 small nuclear ribonucleoprotein complex - 559292 P0C074(0)|P19736(0)|P32524(0)|P40018(0)|P40204(0)|P40565(0)|P40567(0)|P43321(0)|P46947(0)|P49955(0)|P53830(0)|P54999(0)|Q02260(0)|Q02554(0)|Q04693(0)|Q06217(0)|Q06835(0)|Q07350(0)|Q07930(0)|Q08963(0)|Q12330(0)|Q99181(0)|URS000023C730_559292(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0005634(nucleus)|GO:0005686(U2 snRNP)|GO:0045131(pre-mRNA branch point binding)|GO:1903241(U2-type prespliceosome assembly)|GO:0000398(mRNA splicing, via spliceosome)|GO:0005681(spliceosomal complex) pubmed:19941820(see-also)|pubmed:11804584(see-also)|pubmed:22762203(see-also)|complex portal:CPX-26(complex-primary) Non-coding RNA containing complex that is involved in mRNA splicing. U2 snRNP binds to the intron branch site of the commitment complex to form the pre-spliceosome in an ATP dependent step. The spliceosome is a highly dynamic structure, assembled by sequential binding and release of the small nuclear RNAs and protein factors which removes intronic sequence from pre-mRNA. During formation of the activated spliceosome, U2 will replace the dissociating U4 (CPX-31) to form base pairs with U6 (CPX-24). Prior to the first catalytic reaction, the SF3a (CPX-1648) and SF3b (CPX-1647) sub-complexes dissociate from the spliceosome, presumably making the branch site accessible to lariat formation. U2 snRNP includes several sub-complexes: SF3a (CPX-1648), SF3b (CPX-1647), RES complex (CPX-1649) and the Sm ring complex. - - - - - - psi-mi:"-"(Saccharomyces Genome Database) P0C074(0)|P19736(0)|P32524(0)|P40018(0)|P40204(0)|P40565(0)|P40567(0)|P43321(0)|P46947(0)|P49955(0)|P53830(0)|P54999(0)|Q02260(0)|Q02554(0)|Q04693(0)|Q06217(0)|Q06835(0)|Q07350(0)|Q07930(0)|Q08963(0)|Q12330(0)|Q99181(0) +CPX-29 U5 small nuclear ribonucleoprotein complex U5 snRNP complex 559292 P19735(0)|P23394(0)|P32639(0)|P33334(0)|P36048(0)|P38852(0)|P40018(0)|P40204(0)|P43321(0)|P54999(0)|Q02260(0)|Q06217(0)|Q06819(0)|Q12330(0)|URS0000514318_559292(0)|URS000053F313_559292(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0005682(U5 snRNP)|GO:0000398(mRNA splicing, via spliceosome)|GO:0005681(spliceosomal complex)|GO:0005634(nucleus) pubmed:19941820(see-also)|pubmed:11804584(see-also)|pubmed:22012849(see-also)|complex portal:CPX-29(complex-primary)|pubmed:15840809(see-also)|pubmed:22762203(see-also) Non-coding RNA containing complex that is involved in mRNA splicing. U5 snRNP is delivered to the forming spliceosome as part of the U4/U6 x U5 tri-snRNP complex (CPX-25). The spliceosome is a highly dynamic structure, assembled by sequential binding and release of the small nuclear RNAs and protein factors which removes intronic sequence from pre-mRNA. During spliceosome activation several subunits dissociate, but U5 is necessary for both trans-esterification steps during splicing. Contains an Sm ring subcomplex. - - - - - - psi-mi:"-"(Saccharomyces Genome Database) P19735(0)|P23394(0)|P32639(0)|P33334(0)|P36048(0)|P38852(0)|P40018(0)|P40204(0)|P43321(0)|P54999(0)|Q02260(0)|Q06217(0)|Q06819(0)|Q12330(0) +CPX-30 U5 small nuclear ribonucleoprotein complex, AAR2 variant AAR2-U5 snRNP complex 559292 P32357(0)|P33334(0)|P36048(0)|P40018(0)|P40204(0)|P43321(0)|P54999(0)|Q02260(0)|Q06217(0)|Q12330(0)|URS0000514318_559292(0)|URS000053F313_559292(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0005682(U5 snRNP)|GO:0000387(spliceosomal snRNP assembly)|GO:0005737(cytoplasm) complex portal:CPX-30(complex-primary)|pubmed:21764848(see-also)|pubmed:11720285(see-also)|pubmed:17934474(see-also) A - presumably immature - form of the U5 snRNP (CPX-29), that is mainly found in the cytoplasm. AAR2 is mutually exclusive with BRR2, which is present in the form of U5 localized at the spliceosome. The spliceosome is a highly dynamic structure, assembled by sequential binding and release of the small nuclear RNAs and protein factors which removes intronic sequence from pre-mRNA. The size of this form of U5 is 16S. - - - - - - psi-mi:"-"(Saccharomyces Genome Database) P32357(0)|P33334(0)|P36048(0)|P40018(0)|P40204(0)|P43321(0)|P54999(0)|Q02260(0)|Q06217(0)|Q12330(0) +CPX-31 U4 small nuclear ribonucleoprotein complex U4 snRNP complex 559292 P20053(0)|P39990(0)|P40018(0)|P40204(0)|P43321(0)|P54999(0)|Q02260(0)|Q03338(0)|Q06217(0)|Q12330(0)|URS00001143F5_559292(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0005687(U4 snRNP)|GO:0005634(nucleus)|GO:0000398(mRNA splicing, via spliceosome)|GO:0000245(spliceosomal complex assembly) complex portal:CPX-31(complex-primary)|pubmed:22762203(see-also) Non-coding RNA containing complex that is involved in mRNA splicing. U4 is found in a complex with U6 snRNP (the U4/6 snRNP complex, CPX-32), which is an intermediate in the assembly of the spliceosome. The spliceosome is a highly dynamic structure, assembled by sequential binding and release of the small nuclear RNAs and protein factors which removes intronic sequence from pre-mRNA. U4 dissociates from the spliceosome during the activation step. The U4/6 complex is then re-assembled in each cycle. Its function seems to be to deliver U6 to the spliceosome. - - - - - - - psi-mi:"-"(Saccharomyces Genome Database) P20053(0)|P39990(0)|P40018(0)|P40204(0)|P43321(0)|P54999(0)|Q02260(0)|Q03338(0)|Q06217(0)|Q12330(0) +CPX-32 U4/U6 small nuclear ribonucleoprotein complex U4/U6 snRNP 559292 P20053(0)|P38203(0)|P39990(0)|P40018(0)|P40070(0)|P40089(0)|P40204(0)|P43321(0)|P47093(0)|P49704(0)|P53905(0)|P54999(0)|P57743(0)|Q02260(0)|Q03338(0)|Q06217(0)|Q06406(0)|Q12330(0)|URS00001143F5_559292(0)|URS00006184A9_559292(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0071001(U4/U6 snRNP)|GO:0005634(nucleus)|GO:0000398(mRNA splicing, via spliceosome)|GO:0005681(spliceosomal complex) pubmed:19941820(see-also)|pubmed:11804584(see-also)|pubmed:22762203(see-also)|complex portal:CPX-32(complex-primary) Non-coding RNA containing complex that is involved in mRNA splicing. Intermediate complex in the assembly of U4/U6 x U5 tri-snRNP complex (CPX-25) and the precatalytic spliceosome. Its main function is to deliver U6 (CPX-24) to the spliceosome, a highly dynamic structure, assembled by sequential binding and release of the small nuclear RNAs and protein factors which removes intronic sequence from pre-mRNA. - - - - - - - psi-mi:"-"(Saccharomyces Genome Database) P20053(0)|P38203(0)|P39990(0)|P40018(0)|P40070(0)|P40089(0)|P40204(0)|P43321(0)|P47093(0)|P49704(0)|P53905(0)|P54999(0)|P57743(0)|Q02260(0)|Q03338(0)|Q06217(0)|Q06406(0)|Q12330(0) +CPX-36 Kelch-containing Formin Regulatory Complex KFRC|Bud14-Kel1-Kel2 complex 559292 P27637(2)|P38853(2)|P50090(1) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0090337(regulation of formin-nucleated actin cable assembly)|GO:1990615(Kelch-containing formin regulatory complex)|GO:0032465(regulation of cytokinesis)|GO:0060627(regulation of vesicle-mediated transport)|GO:0005934(cellular bud tip)|GO:0005935(cellular bud neck) pubmed:24828508(see-also)|complex portal:CPX-36(complex-primary) Regulates BNR1 (P40450)-mediated actin cable formation, polarized cell growth, and cytokinesis. Localizes to the bud neck and cortex and binds to the FH2 domain of the formin, displacing BNR1 from the growing ends of actin filaments to control actin cable architecture. Actin cables serve as linear tracks for myosin V-based transport of secretory vesicles, organelles, and daughter-specific transcripts to the bud, as well as guiding astral microtubule plus ends to the cell cortex to position and orient the mitotic spindle The Kelch-containing formin regulatory complex is composed of Bud14, Kel1, and Kel2 in a 2:2:1 ratio. It has a sedimentation coefficient of 15.5 S and a Stokes radius of 8.33. Its calculated mass is 527 kDa. Heteropentamer - - - - - psi-mi:"-"(Saccharomyces Genome Database) P27637(2)|P38853(2)|P50090(1) +CPX-43 Sm complex - 559292 P40018(1)|P40204(1)|P43321(1)|P54999(1)|Q02260(1)|Q06217(1)|Q12330(1) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0036261(7-methylguanosine cap hypermethylation)|GO:0000398(mRNA splicing, via spliceosome)|GO:0005686(U2 snRNP)|GO:0005682(U5 snRNP)|GO:0017069(snRNA binding)|GO:0005685(U1 snRNP)|GO:0005687(U4 snRNP) complex portal:CPX-43(complex-primary) Essential role in pre-mRNA splicing. Form a heteroheptameric complex on binding to a conserved Sm site [consensus AU(4-6)G] found in single-stranded regions of U1, U2, U4 and U5 snRNAs. U1, U2, U4 and U5 snRNAs are produced in the nucleus by RNA polymerase II and exported to the cytoplasm, where the Sm proteins bind to them and promote the hypermethylation of the N7-monomethyl guanosine cap at their 5-prime-ends, to produce the 2,2,7-trimethyl guanosine cap structure. Believed to form a heptameric ring. Heteroheptamer - - - - - psi-mi:"-"(Saccharomyces Genome Database) P40018(1)|P40204(1)|P43321(1)|P54999(1)|Q02260(1)|Q06217(1)|Q12330(1) +CPX-44 LSM2-8 complex - 559292 P38203(1)|P40070(1)|P40089(1)|P47093(1)|P53905(1)|P57743(1)|Q06406(1) ECO:0000353(physical interaction evidence used in manual assertion) - GO:0000398(mRNA splicing, via spliceosome)|GO:0008033(tRNA processing)|GO:0005688(U6 snRNP)|GO:0003723(RNA binding)|GO:0006364(rRNA processing)|GO:0005634(nucleus) wwpdb:4c92(identity)|wwpdb:4m7d(identity)|wwpdb:4M77(subset)|wwpdb:4M7A(identity)|complex portal:CPX-44(complex-primary)|pubmed:10369684(see-also)|pubmed:23392247(see-also)|wwpdb:4M78(identity) The hetero-heptameric complex of seven Lsm proteins (Lsm2-8) affects the processing of small stable RNAs (including tRNAs, rRNAs) and pre-mRNAs in the nucleus. The complex is part of the U6 snRNA, where it binds to the U6 RNA and contributes to stabilizing the U6 snRNA and chaperoning it through the splicing process. The Lsm2-8 complex is thought to pre-exist in the cell and bind to U6 as a complex. - Heteroheptamer - - - - - psi-mi:"-"(Saccharomyces Genome Database) P38203(1)|P40070(1)|P40089(1)|P47093(1)|P53905(1)|P57743(1)|Q06406(1) +CPX-45 LSM1-7 complex - 559292 P38203(1)|P40070(1)|P40089(1)|P47017(1)|P53905(1)|P57743(1)|Q06406(1) ECO:0000353(physical interaction evidence used in manual assertion) - GO:0000932(cytoplasmic mRNA processing body)|GO:0000290(deadenylation-dependent decapping of nuclear-transcribed mRNA)|GO:0003730(mRNA 3' UTR binding) complex portal:CPX-45(complex-primary)|wwpdb:4M75(identity)|pubmed:24139796(see-also)|wwpdb:4C92(identity)|pubmed:23392247(see-also) Lsm1-7 is a complex conserved in all eukaryotes and has similar function to the homohexamer Hfq in bacteria. It is an important part of cytoplasmic mRNA degradation. It preferentially binds oligo-adenylated (but not poly-A) mRNAs at their 3' end and promotes decapping at the 5' end thereby directing the mRNA for degradation through the 5' to 3' pathway. Lsm1-7 in yeast can be isolated as part of the Lsm1-7-Pat1 complex. - Heteroheptamer - - - - - psi-mi:"-"(Saccharomyces Genome Database) P38203(1)|P40070(1)|P40089(1)|P47017(1)|P53905(1)|P57743(1)|Q06406(1) +CPX-46 LSM2-7 complex - 559292 P38203(0)|P40070(0)|P40089(0)|P53905(0)|P57743(0)|Q06406(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0005730(nucleolus)|GO:0003723(RNA binding) complex portal:CPX-46(complex-primary)|pubmed:15075370(see-also)|pubmed:10369684(see-also) Sml2-7 proteins form a complex that is found associated with snR5 and pre-Rnase P in yeast nucleoli. The function of this complex is unclear. - - - - - - - psi-mi:"-"(Saccharomyces Genome Database) P38203(0)|P40070(0)|P40089(0)|P53905(0)|P57743(0)|Q06406(0) +CPX-112 LSM1-7-PAT1 complex - 559292 P25644(1)|P38203(1)|P40070(1)|P40089(1)|P47017(1)|P53905(1)|P57743(1)|Q06406(1) ECO:0000353(physical interaction evidence used in manual assertion) - GO:0003730(mRNA 3'-UTR binding)|GO:0000290(deadenylation-dependent decapping of nuclear-transcribed mRNA)|GO:0000932(cytoplasmic mRNA processing body) complex portal:CPX-112(complex-primary)|pubmed:24139796(see-also)|pubmed:17513695(see-also)|wwpdb:4C8Q(identity)|pubmed:19279404(see-also) Lsm1-7-Pat1 is a complex conserved in all eukaryotes. It is an important part of cytoplasmic mRNA degradation. It preferentially binds oligo-adenylated (but not poly-A) mRNAs at their 3' end and promotes decapping at the 5' end thereby directing the mRNA for degradation through the 5' to 3' pathway. Lsm1-7-Pat1 complex might also be involved in protein-protein recognition in the nucleus in the context of the nuclear Lsm2-8 complex (CPX-44). - heterooctamer - - - - - psi-mi:"-"(Saccharomyces Genome Database) P25644(1)|P38203(1)|P40070(1)|P40089(1)|P47017(1)|P53905(1)|P57743(1)|Q06406(1) +CPX-124 HIR complex - 559292 P32479(1)|P32480(2)|P47171(1)|Q01448(2) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-10895677 GO:0000417(HIR complex)|GO:0006334(nucleosome assembly)|GO:1905268(negative regulation of chromatin organization) complex portal:CPX-124(complex-primary)|pubmed:16264190(see-also)|pubmed:9001207(see-also)|pubmed:18091724(see-also) Promotes nucleosome assembly and prevents SWI/SNF chromatin remodeling activity. Binds to and represses transcription of histone genes throughout the cell cycle, but does not repress transcription in G1/S phase; may also acetylate histones. Molecular weight = 617.5 kDa. Heterohexamer - - - - - psi-mi:"-"(Saccharomyces Genome Database) P32479(1)|P32480(2)|P47171(1)|Q01448(2) +CPX-140 MICOS mitochondrial contact site and cristae organizing system complex - 559292 P36112(0)|P38341(0)|P43594(0)|P50087(0)|P50945(0)|Q96VH5(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-7486917 GO:0005739(mitochondrion)|GO:0061617(MICOS complex)|GO:0042407(cristae formation)|GO:0044284(mitochondrial crista junction) complex portal:CPX-140(complex-primary)|pubmed:21987634(see-also)|pubmed:21944719(see-also)|pubmed:25918844(see-also)|pubmed:22009199(see-also) MICOS (MItochondrial contact site and Cristae Organizing System) is a mitochondrial inner membrane complex that extends into the intermembrane space and has a role in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. The Mic60 subunit also has a role in import of inter-membrane space proteins. - - - - - - - psi-mi:"-"(Saccharomyces Genome Database) P36112(0)|P38341(0)|P43594(0)|P50087(0)|P50945(0)|Q96VH5(0) +CPX-154 Bub1-Bub3 complex - 559292 P26449(1)|P41695(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-6472704 GO:1990298(bub1-bub3 complex)|GO:0007094(mitotic spindle assembly checkpoint)|GO:0007094(mitotic spindle assembly checkpoint) complex portal:CPX-154(complex-primary)|wwpdb:2I3S(identity)|protein ontology:PR:000035565(identity)|pubmed:24066227(see-also)|pubmed:17227844(see-also) Present throughout the cell cycle, this complex promotes spindle assembly checkpoint signalling. The spindle checkpoint ensures accurate chromosome segregation by sending a signal from an unattached kinetochore to inhibit anaphase onset. BUB3 localizes and binds to to kinetochore protein SPC105 via its phosphorylated MELT motif (a motif conforming to the consensus M-[E/D]-[L/I/V/M]-T). The presence of BUB1 positively contributes to the interaction by reducing the BUB3-SPC105 binding affinity. - Heterodimer - - - - - psi-mi:"-"(Saccharomyces Genome Database) P26449(1)|P41695(1) +CPX-161 FZO1-MGM1-UGO1 complex - 559292 P32266(0)|P38297(0)|Q03327(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:1990626(mitochondrial outer membrane fusion)|GO:1990627(mitochondrial inner membrane fusion)|GO:0005739(mitochondrion) complex portal:CPX-161(complex-primary)|pubmed:19237599(see-also)|pubmed:12566426(see-also)|pubmed:15087460(see-also) Spans the outer and inner membranes of mitochondria and mediates fusion of membranes. Required to control mitochondria shape, maintain mitochondrial DNA and plays a role in mitochondrial membrane fusion. - - - - - - - psi-mi:"-"(Saccharomyces Genome Database) P32266(0)|P38297(0)|Q03327(0) +CPX-162 Dehydrodolichyl diphosphate synthase complex variant RER2 - 559292 P35196(0)|Q12063(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:1904423(dehydrodolichyl diphosphate synthase complex)|GO:0045547(dehydrodolichyl diphosphate synthase activity)|GO:0019408(dolichol biosynthetic process) complex portal:CPX-162(complex-primary)|pubmed:25066056(see-also) One of two complexes involved in dolichol synthesis. An essential part of the dolichol monophosphate biosynthetic machinery; creates dehydrodolichyl diphosphate (Dedol-PP), a precursor of dolichol, by adding multiple isopentenyl pyrophosphates (IPP) to farnesyl pyrophosphate (FPP). Predominate product is 16 IPP units. - - - - - - - psi-mi:"-"(Saccharomyces Genome Database) P35196(0)|Q12063(0) +CPX-166 Dehydrodolichyl diphosphate synthase complex variant SRT1 - 559292 Q03175(0)|Q12063(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:1904423(dehydrodolichyl diphosphate synthase complex)|GO:0045547(dehydrodolichyl diphosphate synthase activity)|GO:0019408(dolichol biosynthetic process) complex portal:CPX-166(complex-primary)|pubmed:25066056(see-also) One of two complexes involved in dolichol synthesis. An essential part of the dolichol monophosphate biosynthetic machinery; creates dehydrodolichyl diphosphate (Dedol-PP), a precursor of dolichol, by adding multiple isopentenyl pyrophosphates (IPP) to farnesyl pyrophosphate (FPP). Predominate product is 17-19 IPP units. - - - - - - - psi-mi:"-"(Saccharomyces Genome Database) Q03175(0)|Q12063(0) +CPX-231 Snf1 protein kinase complex variant GAL83 Snf1 serine/threonine protein kinase complex|AMPK|AMP-activated protein kinase complex 559292 P06782(1)|P12904(1)|Q04739(1) ECO:0005546(biological system reconstruction evidence based on paralogy evidence used in manual assertion) - GO:0070404(NADH binding)|GO:0004674(protein serine/threonine kinase activity)|GO:0005524(ATP binding)|GO:0043531(ADP binding)|GO:1904547(regulation of cellular response to glucose starvation)|GO:2000217(regulation of invasive growth in response to glucose limitation)|GO:0030447(filamentous growth)|GO:0031588(nucleotide-activated protein kinase complex) complex portal:CPX-2800(inferred-from)|complex portal:CPX-231(complex-primary)|intenz:2.7.11.1(identity)|pubmed:24483210(see-also) Energy sensor protein kinase complex, activated by glucose depletion. Regulates cellular energy metabolism by activating energy-producing pathways and inhibiting energy-consuming processes via derepression of glucose-repressed genes. Required for the diauxic shift, in which genes required for mitochondrial oxidative metabolism (normally repressed by glucose) are switched on; growth then resumes at a lower rate. Role in filamentous invasive growth, on glucose depletion, in haploid cells. Regulates haploid invasive growth in response to glucose depletion by affecting adherence by antagonizing NRG1- and NRG2-mediated repression of the FLO11 flocculin and adhesin gene. The activity of this complex is modulated by reversible phosphorylation of SNF1 Thr-210 which increases in response to glucose starvation and correlates with large increases in cellular ADP-to-ATP and AMP-to-ATP ratios. Binding of ADP, but not AMP, to the complex protects against dephosphorylation of Thr-210, suggesting that ADP, rather than AMP, may be the critical activating signal. When glucose levels are high, the complex is cytoplasmic. Upon glucose depletion, Gal83-containing SNF1 locates to the nucleus. By similarity to the SNF1 protein kinase complex variant SIP2, a central component of the heterotrimer interface is an eight-stranded, mostly antiparallel beta-sheet, formed with four strands from SNF1, three strands from GAL83 and one strand from SNF4 SNF4 binds two molecules of adenine nucleotide and NADH. GAL83 binds carbohydrates. Heterotrimer - - - - - psi-mi:"MI:0469"(IntAct) P06782(1)|P12904(1)|Q04739(1) +CPX-232 Snf1 protein kinase complex variant SIP1 Snf1 serine/threonine protein kinase complex|AMPK|AMP-activated protein kinase complex 559292 P06782(1)|P12904(1)|P32578(1) ECO:0005546(biological system reconstruction evidence based on paralogy evidence used in manual assertion) - GO:0031588(nucleotide-activated protein kinase complex)|GO:0070404(NADH binding)|GO:0004674(protein serine/threonine kinase activity)|GO:0005524(ATP binding)|GO:0043531(ADP binding)|GO:1904547(regulation of cellular response to glucose starvation) complex portal:CPX-2800(inferred-from)|complex portal:CPX-232(complex-primary)|intenz:2.7.11.1(identity)|pubmed:24483210(see-also) Energy sensor protein kinase complex, activated by glucose depletion. Regulates cellular energy metabolism by activating energy-producing pathways and inhibiting energy-consuming processes via derepression of glucose-repressed genes. Required for the diauxic shift, in which genes required for mitochondrial oxidative metabolism (normally repressed by glucose) are switched on; growth then resumes at a lower rate. The activity of this complex is modulated by reversible phosphorylation of SNF1 Thr-210 which increases in response to glucose starvation and correlates with large increases in cellular ADP-to-ATP and AMP-to-ATP ratios. Binding of ADP, but not AMP, to the complex protects against dephosphorylation of Thr-210, suggesting that ADP, rather than AMP, may be the critical activating signal. When glucose levels are high, the complex is cytoplasmic. Upon glucose depletion, SIP1-containing SNF1 locates to the vacuolar membrane. By similarity to the SNF1 protein kinase complex variant SIP2, a central component of the heterotrimer interface is an eight-stranded, mostly antiparallel beta-sheet, formed with four strands from SNF1, three strands from GAL83 and one strand from SNF4 SNF4 binds two molecules of adenine nucleotide and NADH. GAL83 binds carbohydrates. Heterotrimer - - - - - psi-mi:"MI:0469"(IntAct) P06782(1)|P12904(1)|P32578(1) +CPX-242 FAL1-SGD1 complex - 559292 Q06132(0)|Q12099(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-11303075 GO:0097078(FAL1-SGD1 complex)|GO:0032774(RNA biosynthetic process) complex portal:CPX-242(complex-primary)|pubmed:21576267(see-also) Involved in 18S rRNA biogenesis. - - - - - - - psi-mi:"-"(Saccharomyces Genome Database) Q06132(0)|Q12099(0) +CPX-297 CMG helicase complex Cdc45-MCM-GINS complex 559292 CPX-1641(0)|CPX-2944(0)|Q08032(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-16196015 GO:0071162(CMG complex)|GO:0005524(ATP binding)|GO:0003697(single-stranded DNA binding)|GO:0043596(nuclear replication fork)|GO:0003678(DNA helicase activity)|GO:0006268(DNA unwinding involved in DNA replication)|GO:0005634(nucleus) intenz:3.6.4.12(identity)|wwpdb:3jc6(identity)|emdb:EMD-6534(identity)|wwpdb:3jc5(identity)|emdb:EMD-6535(identity)|wwpdb:3jc7(identity)|emdb:EMD-6536(identity)|complex portal:CPX-297(complex-primary) DNA helicase that unwinds or rearranges duplex DNA during replication, recombination and repair. Surrounds the leading strand during DNA replication and recruits the DNA polymerase epsilon complex (CPX-2110) for leading-strand synthesis. CDC45 adds the GINS complex (CPX-1641) onto each MCM2-7 complex (CPX-2944) to form two active CMG helicases that surround each strand of parental DNA. CMG then translocates along single-strand DNA in the 3-prime to 5-prime direction for bidirectional replication. The complex unwinds duplex regions up to 500 bp. The complex has a 20 A diameter opening at the bottom N-terminal domain (NTD) ring of the the MCM2-7 core forms a two-tiered ring structure, where the leading strand exits the MCM2-7 axial channel. The axial channel in the NTD ring is partially obstructed by two protruding loops that connect the first two beta-strands of the OB sub-domains (IPR033762) in MCM4 and MCM7 which are positioned directly below the ssDNA pore of the C-terminal domain (CTD)-the MCM2-7 complex ring where DNA enters. The CTD motor ring appears to tilt up and down relative to a rigid NTD ring-CDC45-GINS platform - - - - - - psi-mi:"-"(Saccharomyces Genome Database) P24279(0)|P29469(0)|P29496(0)|P30665(0)|P38132(0)|P40359(0)|P53091(0)|Q03406(0)|Q08032(0)|Q12146(0)|Q12488(0) +CPX-301 GID ubiquitin ligase complex GID E3 ligase|GID ubiquitin ligase complex|FBP degradation complex 559292 P25569(1)|P38263(1)|P40208(1)|P40492(1)|P40547(1)|P53076(1)|Q12508(1) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0034657(GID complex)|GO:0043161(proteasome-mediated ubiquitin-dependent protein catabolic process)|GO:0061630(ubiquitin protein ligase activity)|GO:0016755(transferase activity, transferring amino-acyl groups) complex portal:CPX-301(complex-primary)|pubmed:22645139(see-also)|pubmed:12686616(see-also)|pubmed:22044534(see-also)|intenz:2.3.2.27(identity) E3 ligase complex that triggers polyubiquitylation and subsequent proteasomal degradation of the gluconeogenic enzymes fructose-1,6-bisphosphatase (FBPase), phosphoenolpyruvate carboxykinase (PEPCK and cytoplasmic malate dehydrogenase (c-MDH). E3 ubiquitin ligase activity is provided by Rmd5 and Fyv10. Orthologous to mammalian CTLH complex. 600 kDa complex. Under gluconeogenic conditions, there are only six subunits (Vid30, Rmd5, Vid28, Gid7, Gid8, and Fyv10). With the addition of glucose, Vid24, the seventh component, joins the complex and triggers ubiquitination of FBPase, leading to rapid degradation. Heteroheptamer - - - - - psi-mi:"-"(Saccharomyces Genome Database) P25569(1)|P38263(1)|P40208(1)|P40492(1)|P40547(1)|P53076(1)|Q12508(1) +CPX-302 Mitochondrial pyruvate carrier, fermentative isoform - 559292 P38857(1)|P53157(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-11357847 GO:0006850(mitochondrial pyruvate transmembrane transport)|GO:0050833(pyruvate transmembrane transporter activity)|GO:0098800(inner mitochondrial membrane protein complex) complex portal:CPX-302(complex-primary)|pubmed:22628558(see-also)|pubmed:25672363(see-also)|pubmed:22628554(see-also) The fermentative isoform of the mitochondrial pyruvate carrier resides in the mitochondrial inner membrane and mediates uptake of pyruvate into the mitochondrion during growth on fermentable carbon sources such as glucose. The Mpc1 subunit has two transmembrane segments with a connecting loop that is in the mitochondrial intermembrane space (IMS); its N and C termini extend into the mitochondrial matrix. The Mpc2 subunit has three transmembrane segments; its N terminus and an internal loop are in the matrix, while its C terminus and an internal loop are in the IMS. The two subunits form a heterodimer. Mpc1 is expressed constitutively and is also a component of the respiratory isoform of the mitochondrial pyruvate carrier, while Mpc2 is expressed only during fermentative growth. Heterodimer - - - - - psi-mi:"-"(Saccharomyces Genome Database) P38857(1)|P53157(1) +CPX-303 Mitochondrial pyruvate carrier, respiratory isoform - 559292 P53157(1)|P53311(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-11357855 GO:0050833(pyruvate transmembrane transporter activity)|GO:0098800(inner mitochondrial membrane protein complex)|GO:0006850(mitochondrial pyruvate transmembrane transport) complex portal:CPX-303(complex-primary)|pubmed:25672363(see-also)|pubmed:22628554(see-also)|pubmed:22628558(see-also) The respiratory isoform of the mitochondrial pyruvate carrier resides in the mitochondrial inner membrane and mediates uptake of pyruvate into the mitochondrion during growth on respiratory carbon sources such as ethanol and glycerol. The Mpc1 subunit has two transmembrane segments with a connecting loop that is in the mitochondrial intermembrane space (IMS); its N and C termini extend into the mitochondrial matrix. The Mpc3 subunit has three transmembrane segments; its N terminus and an internal loop are in the matrix, while its C terminus and an internal loop are in the IMS. The two subunits form a heterodimer. Mpc1 is expressed constitutively and is also a component of the fermentative isoform of the mitochondrial pyruvate carrier, while Mpc3 is expressed only during respiratory growth. Heterodimer - - - - - psi-mi:"-"(Saccharomyces Genome Database) P53157(1)|P53311(1) +CPX-307 Endoplasmic Reticulum Membrane Complex - 559292 P25574(0)|P36039(0)|P40540(0)|P47133(0)|P53073(0)|Q12431(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0072546(ER membrane protein complex)|GO:0015914(phospholipid transport)|GO:0006644(phospholipid metabolic process) complex portal:CPX-307(complex-primary)|pubmed:19325107(see-also)|pubmed:25313861(see-also) Required for transfer of phosphatidylserine (PS) from the endoplasmic reticulum to mitochondria. Complex is tethered to the ER and mitochondria through Tom5 (P80967). - - - - - - - psi-mi:"-"(Saccharomyces Genome Database) P25574(0)|P36039(0)|P40540(0)|P47133(0)|P53073(0)|Q12431(0) +CPX-325 Glutathione hydrolase complex GSH degradosomal complex 559292 P38149(2)|P53871(2) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-11475041 GO:0036374(glutathione hydrolase activity)|GO:0061672(glutathione hydrolase complex)|GO:0006751(glutathione catabolic process) complex portal:CPX-325(complex-primary)|pubmed:22277648(see-also)|intenz:3.4.19.13(identity) Glutathione hydrolase/Glutamine Amidotransferase II complex responsible for glutathione degradation. Both DUG2 and DUG3 are depressed under sulfur limitation conditions. Although neither protein alone can cleave glutathione, the complex degrades glutathione by cleaving of the gamma-glutamyl linkage. DUG3 has the GATase activity, while DUG2 probably acts as a scaffold protein, bringing two DUG3 proteins together. Purified complex is approximately 300 kDa with a Km of 1.2mM. - - - - - - psi-mi:"-"(Saccharomyces Genome Database) P38149(2)|P53871(2) +CPX-334 VPS4 complex ESCRT-IV complex|Vacuolar protein sorting-associated complex|Endosomal sorting complex required for transport-IV complex 559292 P52917(0) ECO:0000353(physical interaction evidence used in manual assertion) - GO:0031468(nuclear envelope reassembly)|GO:0001778(plasma membrane repair)|GO:0006997(nucleus organization)|GO:0097352(autophagosome maturation)|GO:0006914(autophagy)|GO:0005886(plasma membrane)|GO:0005524(ATP binding)|GO:0005643(nuclear pore)|GO:0030496(midbody)|GO:0036258(multivesicular body assembly)|GO:1904949(ATPase complex)|GO:0060548(negative regulation of cell death)|GO:0061952(midbody abscission)|GO:0061764(late endosome to lysosome transport via multivesicular body sorting pathway)|GO:0071985(multivesicular body sorting pathway)|GO:0090148(membrane fission)|GO:0016887(ATPase activity) complex portal:CPX-334(complex-primary)|intenz:3.6.4.6(identity)|wwpdb:2rko(subset)|emdb:1481(identity)|pubmed:21925211(see-also)|emdb:5040(identity) An AAA-ATPase that is probably the main energy-providing system for the membrane deformation and abscission function of the ESCRT machinery consisting of ESCRT-0 (CPX-1622), -I (CPX-940), -II (CPX-1623), -III (CPX-1624) and -IV (this complex) . Required for the dissociation and recycling of ESCRT-III complex subunits from vesicle and plasma membranes as well as the midbody during the final stages of cytokinesis where it causes constriction of the ESCRT-III polymer and fission of the associated membrane neck. Multiple disassembly reactions are performed until ESCRT-III dissociation has been completed. VPS4 ATPase activity is regulated by a) ESCRT-III interactions with VPS4 which enhance ATP hydrolysis by relieving autoinhibition of the AAA domain and b) binding of the VTA1 homodimers (Q06263) which both promotes VPS4 oligomerization and enhances ATP hydrolysis. Binding of ESCRT-III subunits DID2 (P69771) or VPS60 (Q03390) to the amino-terminal of VTA1 relieves autoinhibition within VTA1 to further enhance stimulation of VPS4 ATP hydrolysis. Binding of IST1 (P53843) to VPS4 negatively regulates VPS4 activity by blocking binding to the ESCRT machinery. Soluble, catalytically inactive dimers or hexamers oligomerise upon interaction of its MIT domain with ESCRT-III MIM1 and/or MIM2 domains forming two stacked hexameric or heptameric rings with a central pore through which ESCRT-III substrates are translocated in an ATP-dependent manner. - - - - - - psi-mi:"MI:0469"(IntAct) P52917(0) +CPX-335 CLB1-CDC28 kinase complex - 559292 P00546(0)|P24868(0) ECO:0005546(biological system reconstruction evidence based on paralogy evidence used in manual assertion) - GO:0004693(cyclin-dependent protein serine/threonine kinase activity)|GO:0000086(G2/M transition of mitotic cell cycle)|GO:0000307(cyclin-dependent protein kinase holoenzyme complex) complex portal:CPX-342(inferred-from)|complex portal:CPX-335(complex-primary)|intenz:2.7.11.22(identity)|pubmed:1849457(see-also) Cyclin-dependent protein kinase complex required for the control of the cell cycle at the G2/M (mitosis) transition. Mitotic cyclin-CDKs (M-CDKs) regulate accurate chromosome segregation through mitosis. CDKs have a two-lobed structure. The amino-terminal lobe contains beta-sheets, the carboxy-terminal lobe is rich in alpha-helices, and the active site is sandwiched in-between. In the cyclin-free, monomeric form the CDK catalytic cleft is closed by a region known as the T-loop, preventing enzymatic activity. Cyclin binding leads to a conformational change, enabling activation of catalytic activity. - - - - - - psi-mi:"MI:0469"(IntAct) P00546(0)|P24868(0) +CPX-336 CLB3-CDC28 kinase complex - 559292 P00546(0)|P24870(0) ECO:0005546(biological system reconstruction evidence based on paralogy evidence used in manual assertion) - GO:0004693(cyclin-dependent protein serine/threonine kinase activity)|GO:0000086(G2/M transition of mitotic cell cycle)|GO:0000307(cyclin-dependent protein kinase holoenzyme complex) complex portal:CPX-342(inferred-from)|complex portal:CPX-336(complex-primary)|intenz:2.7.11.22(identity) Cyclin-dependent protein kinase complex required for the control of the cell cycle at the G2/M (mitosis) transition. Mitotic cyclin-CDKs (M-CDKs) regulate accurate chromosome segregation through mitosis. CDKs have a two-lobed structure. The amino-terminal lobe contains beta-sheets, the carboxy-terminal lobe is rich in alpha-helices, and the active site is sandwiched in-between. In the cyclin-free, monomeric form the CDK catalytic cleft is closed by a region known as the T-loop, preventing enzymatic activity. Cyclin binding leads to a conformational change, enabling activation of catalytic activity. - - - - - - psi-mi:"MI:0469"(IntAct) P00546(0)|P24870(0) +CPX-337 CLB4-CDC28 kinase complex - 559292 P00546(0)|P24871(0) ECO:0005546(biological system reconstruction evidence based on paralogy evidence used in manual assertion) - GO:0004693(cyclin-dependent protein serine/threonine kinase activity)|GO:0000086(G2/M transition of mitotic cell cycle)|GO:0000307(cyclin-dependent protein kinase holoenzyme complex) complex portal:CPX-1702(inferred-from)|complex portal:CPX-337(complex-primary)|intenz:2.7.11.22(identity) Cyclin-dependent protein kinase complex required for the control of the cell cycle at the G2/M (mitosis) transition. Mitotic cyclin-CDKs (M-CDKs) regulate accurate chromosome segregation through mitosis. CDKs have a two-lobed structure. The amino-terminal lobe contains beta-sheets, the carboxy-terminal lobe is rich in alpha-helices, and the active site is sandwiched in-between. In the cyclin-free, monomeric form the CDK catalytic cleft is closed by a region known as the T-loop, preventing enzymatic activity. Cyclin binding leads to a conformational change, enabling activation of catalytic activity. - - - - - - psi-mi:"MI:0469"(IntAct) P00546(0)|P24871(0) +CPX-339 CLB6-CDC28 kinase complex CDK1-CGS5 complex|CDK-S complex 559292 P00546(0)|P32943(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-11565885 GO:0004693(cyclin-dependent protein serine/threonine kinase activity)|GO:0000307(cyclin-dependent protein kinase holoenzyme complex)|GO:0000083(regulation of transcription involved in G1/S transition of mitotic cell cycle) complex portal:CPX-339(complex-primary)|intenz:2.7.11.22(identity) Cyclin-dependent protein kinase complex required for the control of the cell cycle during S-phase where it is required to activate DNA replication. CDKs have a two-lobed structure. The amino-terminal lobe contains beta-sheets, the carboxy-terminal lobe is rich in alpha-helices, and the active site is sandwiched in-between. In the cyclin-free, monomeric form the CDK catalytic cleft is closed by a region known as the T-loop, preventing enzymatic activity. Cyclin binding leads to a conformational change, enabling activation of catalytic activity. - - - - - - psi-mi:"MI:0469"(IntAct) P00546(0)|P32943(0) +CPX-342 CLN2-CDC28 kinase complex CDK1-CG12 complex 559292 P00546(0)|P20438(0)|P20486(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-11580050 GO:1902806(regulation of cell cycle G1/S phase transition)|GO:0004693(cyclin-dependent protein serine/threonine kinase activity)|GO:0000307(cyclin-dependent protein kinase holoenzyme complex) complex portal:CPX-342(complex-primary)|intenz:2.7.11.22(identity) Cyclin-dependent protein kinase complex required for the control of the cell cycle at the G1/S (start) transition, controlling the trigger of post-Start processes such as spindle pole body duplication, and the initiation of DNA replication. CKS1 is required for activity of CLN-CDC28 complexes. The protein may also play a role in complex stability and substrate recognition. CDKs have a two-lobed structure. The amino-terminal lobe contains beta-sheets, the carboxy-terminal lobe is rich in alpha-helices, and the active site is sandwiched in-between. In the cyclin-free, monomeric form the CDK catalytic cleft is closed by a region known as the T-loop, preventing enzymatic activity. Cyclin binding leads to a conformational change, enabling activation of catalytic activity. - - - - - - psi-mi:"MI:0469"(IntAct) P00546(0)|P20438(0)|P20486(0) +CPX-361 ATG2-ATG18 complex - 559292 P43601(0)|P53855(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-11685324 GO:0000045(autophagosome assembly)|GO:0032991(protein-containing complex)|GO:0016236(macroautophagy)|GO:0008429(phosphatidylethanolamine binding)|GO:0034045(pre-autophagosomal structure membrane) complex portal:CPX-361(complex-primary)|pubmed:25747593(see-also)|pubmed:21801009(see-also) Essential for autophagy during nutrient deprivation, a catabolic process that sequesters undesired cellular material into autophagosomes for delivery to lysosomes for degradation. Contributes to nutrition homeostasis and damage control in eukaryotic cells. Functions at a late step of autophagosome formation for efficient completion of sequestration, probably through facilitating recruitment of ATG8-phosphatidylethanolamine (PE) to the preautophagosomal structure (PAS) and/or its protection from deconjugation by ATG4. The Atg2-binding site of Atg18 is located in a stretch of amino acids connecting beta-sheets between WD repeats 2 and 3 of the beta-propeller. - - - - - - psi-mi:"MI:0469"(IntAct) P43601(0)|P53855(0) +CPX-384 CBP3-CBP6 complex - 559292 P07253(0)|P21560(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-11665494 GO:0097177(mitochondrial ribosome binding)|GO:0050821(protein stabilization)|GO:0005739(mitochondrion)|GO:0061671(Cbp3p-Cbp6 complex)|GO:0034551(mitochondrial respiratory chain complex III assembly) pubmed:23007649(see-also)|complex portal:CPX-384(complex-primary) Role in both the efficient synthesis of cytochrome b and protection of the newly synthesized protein from proteolysis. Associates with mitochondrial ribosomes at the polypeptide tunnel exit and is necessary for efficient translation of cytochrome b transcript. Also interacts directly with newly synthesized cytochrome b in an assembly intermediate that is not ribosome bound and coordinates cytochrome b synthesis with mitochondrial electron transport complex III (CPX-567) assembly. - - - - - - - psi-mi:"MI:0469"(IntAct) P07253(0)|P21560(0) +CPX-385 CFD1-NBP35 complex Nbp35-Cfd1 complex|Ndor1-anamorsin complex|NADPH-dependent diflavin oxidoreductase 1-anamorsin complex 559292 CHEBI:49883(4)|P40558(2)|P52920(2) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-11665954 GO:0016226(iron-sulfur cluster assembly)|GO:1904564(Nbp35-Cfd1 ATPase complex)|GO:1990229(iron-sulfur cluster assembly complex)|GO:0016887(ATPase activity)|GO:0005524(ATP binding)|GO:0005829(cytosol) pubmed:26195633(see-also)|pubmed:17401378(see-also)|complex portal:CPX-385(complex-primary) Scaffold complex that assembles nascent FeS clusters as part of the iron-sulfur cluster (ISC) assembly system, for transfer to FeS-requiring enzymes. NBP35 appears to bind the major portion of FeS clusters in the complex whereas CFD1 enhances this binding and drives the release of FeS to target apo-FeS proteins. The complex appears to have low level ATPase activity. Molecular weight =140 kDa. CFD1 and NBP35 bind a bridging [4Fe-4S] cluster at their C-termini and the lability of binding of this cluster may be ideal for its transfer from the scaffold complex toward apoproteins. Depending on isolation conditions, there is also evidence of the complex existing as a heterodimer. Heterotetramer - - - - - psi-mi:"MI:0469"(IntAct) P40558(2)|P52920(2) +CPX-386 TAH18-DRE2 complex DRE2-TAH18 complex 559292 CHEBI:49601(0)|CHEBI:49883(0)|CHEBI:57692(0)|CHEBI:58210(0)|P36152(0)|Q12181(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-6346701 GO:0034599(cellular response to oxidative stress)|GO:0097361(CIA complex)|GO:0016226(iron-sulfur cluster assembly)|GO:0009055(electron carrier activity)|GO:1905118(positive regulation of ribonucleoside-diphosphate reductase activity)|GO:0005829(cytosol) pubmed:21902732(see-also)|intenz:1.18.1(identity)|complex portal:CPX-386(complex-primary)|pubmed:18625724(see-also) Protein complex that supplies reducing equivalents to the early steps of the cytosolic Fe-S assembly (CIA) pathway and also functions in ribonucleotide reductase cluster assembly, potentially also supplying reducing equivalents to the di-iron cluster. Electrons from NADPH are transferred via FAD and FMN, the two flavin cofactors in TAH18, to the Fe-S cluster(s) in DRE2, which subsequently deliver the electrons to proteins in the CIA pathway and RNR2 (P09938). The presence of the [4Fe-4S] iron-sulfur cluster on Dre2 is not conclusively proven. - - - - - - psi-mi:"MI:0469"(IntAct) P36152(0)|Q12181(0) +CPX-393 Phosphopantothenoylcysteine decarboxylase complex PPCDC complex|PPC-DC complex|CoaC complex|CoA caroxylase complex|Hal3-Vhs3-Cab3 complex 559292 P36024(1)|P36076(1)|Q08438(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-11683921 GO:0004633(phosphopantothenoylcysteine decarboxylase activity)|GO:0015937(coenzyme A biosynthetic process)|GO:0071513(phosphopantothenoylcysteine decarboxylase complex) complex portal:CPX-393(complex-primary)|intenz:4.1.1.36(identity)|pubmed:26514574(see-also) Catalyses the third step of the coenzyme A (CoA) biosynthetic pathway, namely the decarboxylation of 4'-phosphopantothenoylcysteine to form 4′-phosphopantetheine. May potentially be part of a larger Coenzyme A-synthesizing protein complex (CPX-396) but this is not yet clear. The synthesis of CoA involves the phosphorylation of pantothenate (vitamin B5) to 4'-phosphopantothenate, to which a cysteine is then added to form 4'-phospho-N-pantothenoylcysteine (PCC). PPC is decarboxylated to 4'-phosphopantetheine by phosphopantothenoylcysteine decarboxylase (this complex). 4'-phosphopantetheine is adenylylated to form dephospho-CoA which is then phosphorylated to form coenzyme A. Two catalytically essential residues are required - His that is required for the first step of the enzyme’s two-step mechanism (an oxidative decarboxylation), and a Cys that is necessary for the second step (the reduction of the reaction intermediate). These are found on opposite sides of the active site, with VHS3 contributing the His residue whilst CAB3 contributes the Cys residue to give a complex with a single functional active site. Heterotrimer - - - - - psi-mi:"MI:0469"(IntAct) P36024(1)|P36076(1)|Q08438(1) +CPX-396 Coenzyme A-synthesizing protein complex - 559292 P36076(0)|P40506(0)|P53332(0)|Q03941(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0015937(coenzyme A biosynthetic process)|GO:0004595(pantetheine-phosphate adenylyltransferase activity)|GO:1990143(CoA-synthesizing protein complex)|GO:0004140(dephospho-CoA kinase activity)|GO:0004632(phosphopantothenate--cysteine ligase activity) intenz:2.7.7.3(identity)|intenz:6.3.2.5(identity)|intenz:2.7.1.24(identity)|pubmed:23789928(see-also)|complex portal:CPX-396(complex-primary) Catalyses multiple steps in the coenzyme A (CoA) biosynthetic pathway, with the CAB3 protein potentially acting as a scaffold to which other enzymes bind. This may be a larger complex, also incorporating the Phosphopantothenoylcysteine decarboxylase complex (CPX-393) but this is not yet clear. The synthesis of CoA involves the phosphorylation of pantothenate (vitamin B5) to 4'-phosphopantothenate, to which a cysteine is then added to form 4'-phospho-N-pantothenoylcysteine (PCC). PPC is decarboxylated to 4'-phosphopantetheine by phosphopantothenoylcysteine decarboxylase (CPX-393). 4'-phosphopantetheine is adenylylated to form dephospho-CoA which is then phosphorylated to form coenzyme A. Molecular weight = 330 kDa. CAB3 may be a homodimer in the complex. - - - - - - psi-mi:"MI:0469"(IntAct) P36076(0)|P40506(0)|P53332(0)|Q03941(0) +CPX-397 Atg17-Atg31-Atg29 complex - 559292 Q06410(2)|Q12092(2)|Q12421(2) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-6559021 GO:0032991(protein-containing complex)|GO:0060090(molecular adaptor activity)|GO:0006914(autophagy)|GO:0005737(cytoplasm) pubmed:19755117(see-also)|pubmed:26753620(see-also)|pubmed:23219485(see-also)|complex portal:CPX-397(complex-primary) Scaffolding complex required for the assembly of the preautophagosomal structure (PAS), the first step of autophagosome formation. Constructively present under both growing and starvation conditions. Under conditions of nutrient starvation, it forms a complex with ATG1 and ATG13 to enhance the kinase activity of ATG1 (CPX-1676). Adopts a dimeric, S-shaped architecture that spans a length of approximately 345 A. Atg17 mediates dimerization and forms the central scaffold of the complex. Interaction with Atg31 and Atg29 restricts the inherent flexibility of Atg17 and establishes its characteristic curvature. - - - - - - psi-mi:"MI:0469"(IntAct) Q06410(2)|Q12092(2)|Q12421(2) +CPX-416 Glutamyl-tRNA(Gln) amidotransferase complex Glu-tRNA-dependent amidotransferase complex|GatCAB AdT complex|Glu-AdT complex 559292 P33893(0)|P53260(0)|Q03557(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-11702415 GO:0070681(glutaminyl-tRNAGln biosynthesis via transamidation)|GO:0005739(mitochondrion)|GO:0050567(glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity)|GO:0030956(glutamyl-tRNA(Gln) amidotransferase complex) complex portal:CPX-416(complex-primary)|intenz:6.3.5.7(identity) Generates glutaminyl-tRNA(Gln) in the mitochondrion. Cytosolic glutamyl-tRNA synthetase (ERS) is imported into mitochondria, where it constitutes the mitochondrial nondiscriminating ERS that generates the mitochondrial misacylated glutamyl-tRNA(Gln) substrate for the Glutamyl-tRNA(Gln) amidotransferase complex. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). - - - - - - - psi-mi:"MI:0469"(IntAct) P33893(0)|P53260(0)|Q03557(0) +CPX-417 Glucosidase II complex G-II complex|Glucosidase 2 complex|Alpha-glucosidase II complex 559292 P38138(0)|Q04924(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-977654 GO:0033919(glucan 1,3-alpha-glucosidase activity)|GO:0000271(polysaccharide biosynthetic process)|GO:0070880(fungal-type cell wall beta-glucan biosynthetic process)|GO:0017177(glucosidase II complex)|GO:0006491(N-glycan processing) intenz:3.2.1.84(identity)|complex portal:CPX-417(complex-primary) Glycoprotein-processing enzyme that successively cleaves the innermost two alpha1,3-linked glucose residues from N-linked oligosaccharides in the endoplasmic reticulum during glycoprotein biogenesis. The enzyme has dual activity, cleaving two alpha1,3-linked glucose residues in succession from Glc2Man9GlcNAc2 (G2M9) to Glc1Man9GlcNAc2 (G1M9) (cleavage-1), and then to Man9GlcNAc2 (M9) (cleavage-2). G1M9 plays a key role in glycoprotein quality control in the ER, because it is a primary ligand of the lectin chaperones calnexin (CNX) and calreticulin (CRT). Therefore, the cleavage-2 activity provides an exit for correctly folded glycoproteins from the CNX/CRT cycle, while the cleavage-1 activity provides an entry for immature glycoproteins into the cycle. Lumenally-oriented soluble enzyme - - - - - - psi-mi:"MI:0469"(IntAct) P38138(0)|Q04924(0) +CPX-418 MTQ2-TRM112 eRF1 methyltransferase complex S-adenosylmethionine-dependent eRF1 methyltransferase complex|S-adenosylmethionine-dependent methyltransferase complex|S-adenosyl-L-methionine-dependent methyltransferase complex|SAM-dependent methyltransferase complex 559292 P53738(1)|Q03920(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-11702657 GO:0035657(eRF1 methyltransferase complex)|GO:0008757(S-adenosylmethionine-dependent methyltransferase activity)|GO:0005840(ribosome)|GO:0018364(peptidyl-glutamine methylation)|GO:0060566(positive regulation of DNA-templated transcription, termination)|GO:0008276(protein methyltransferase activity) pubmed:28134793(see-also)|complex portal:CPX-418(complex-primary)|pubmed:17008308(see-also)|intenz:2.1.1(identity) S-adenosylmethionine-dependent methyltransferase responsible for methylating Gln-182 present in the conserved GGQ motif of the eRF1 subunit of the class 1 peptide chain release factor eRF1-eRF3 complex. Methylation occurs in the presence of GTP. This terminates the translation of nascent peptides in response to the termination codons UAA, UAG and UGA. Uses S-adenosyl L-methionine as methyl donor. MW = 40.8 kDa Heterodimer - - - - - psi-mi:"MI:0469"(IntAct) P53738(1)|Q03920(1) +CPX-422 ELG1-RFC complex Elg1 replication factor C-like complex|Elg1-RLC|Elg1-RFC-like complex 559292 P38251(1)|P38629(1)|P40339(1)|P40348(1)|Q12050(1) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0005634(nucleus)|GO:0003682(chromatin binding)|GO:0090618(DNA clamp unloading)|GO:0031391(Elg1 RFC-like complex) pubmed:26212319(see-also)|complex portal:CPX-422(complex-primary)|pubmed:23499004(see-also)|pubmed:15964801(see-also) Role in sister chromatid cohesion, unloading both unmodified and SUMOylated PCNA from DNA following replication. This is a genome-wide process and follows Okazaki fragment ligation. - Heteropentamer - - - - - psi-mi:"MI:0469"(IntAct) P38251(1)|P38629(1)|P40339(1)|P40348(1)|Q12050(1) +CPX-425 Elongation Factor eEF1 complex, variant TEF4 eEF1A-eEF1Ba-eEF1Bg2 complex|Eukaryotic elongation factor 1 complex 559292 P02994(2)|P32471(2)|P36008(2) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0005840(ribsome)|GO:0006414(translational elongation)|GO:0003746(translation elongation factor activity)|GO:0019003(GDP binding)|GO:0003924(GTPase activity)|GO:0005085(guanyl-nucleotide exchange factor activity)|GO:0005525(GTP binding)|GO:0005853(eukaryotic translation elongation factor 1 complex) wwpdb:1g7c(subset)|wwpdb:1ijf(subset)|wwpdb:1ije(subset)|wwpdb:2b7c(subset)|wwpdb:1f60(subset)|wwpdb:2b7b(subset)|pubmed:12972429(see-also)|pubmed:3528160(see-also)|pubmed:12008673(see-also)|complex portal:CPX-425(complex-primary) Transports an aminoacylated-tRNA (aa-tRNA) to the ribosomal A-site during the elongation phase of protein synthesis. GTP bound to eEF1A (TEF1/2) is hydrolyzed upon codon-anticodon match between an aa-tRNA in the ribosomal RNA A-site and mRNA bound to the ribosome. Inactive eEF1A-GDP leaves the ribosome and must be recycled to eEF1A-GTP before binding another molecule of aa-tRNA. The guanine nucleotide exchange factor eEF1B catalyzes the exchange of GDP for GTP. Molecular weight=240kDa Heterohexamer - - - - - psi-mi:"MI:0469"(IntAct) P02994(2)|P32471(2)|P36008(2) +CPX-426 PAN1 actin cytoskeleton-regulatory complex Pan1p/Sla1p/End3p complex|Pan1/Sla1/End3 complex 559292 P32521(1)|P32790(0)|P39013(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-976262 GO:0071555(cell wall organization)|GO:1990964(actin cytoskeleton-regulatory complex)|GO:0006897(endocytosis) complex portal:CPX-426(complex-primary) Actin cytoskeleton-regulatory complex which is believed to be required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton, coordinating ARP2/3 stimulation at the later stages of endocytosis. Present in the late endocytic coat. END3 and PAN1 appear to be constitutively bound. The inclusion of SLA1 in the complex appear to be dependent on the phosphorylation status of PAN1. phosphorylation of PAN1 terminates its ARP2/3 activation, disrupts its association with SLA1, and returns PAN1 to the cytosol. - - - - - - psi-mi:"MI:0469"(IntAct) P32521(1)|P32790(0)|P39013(1) +CPX-427 Eukaryotic translation initiation factor 2 complex IF2 complex|eIF2 complex|eIF-2 complex|IF-2 complex 559292 P09064(1)|P20459(1)|P32481(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-11710491 GO:0005850(eukaryotic translation initiation factor 2 complex)|GO:0005525(GTP binding)|GO:0003743(translation initiation factor activity)|GO:1990856(methionyl-initiator methionine tRNA binding)|GO:0006413(translational initiation)|GO:0005840(ribosome) complex portal:CPX-427(complex-primary)|pubmed:8947054(see-also) Delivers initiator methionyl-tRNA to the 40S ribosomal subunit in a eukaryotic translation initiation factor 2 (eIF2).GTP.Met-tRNA(Met) ternary complex. The resulting 43S complex, which also includes eIF3 and eIF1A, binds at or near the 5-prime end of capped eukaryotic messenger RNAs. Recognition of the AUG codon translational start site is accompanied by GTP hydrolysis (stimulated by the eIF5 complex), which releases Met-tRNA to the ribosomal peptidyl site and converts eIF2-GTP to eIF2-GDP. Binding of nucleotide exchange factor eIF2B complex (CPX-429) replaces GDP again for GTP. This activity is inhibited when phosphorylated eIF2 (alpha subunit) binds to eIF2B. Phosphorylation of eIF2 occurs in response to nutrient starvation and thus prevents further protein synthesis. Molecular weight = 125 kDa Heterotrimer - - - - - psi-mi:"MI:0469"(IntAct) P09064(1)|P20459(1)|P32481(1) +CPX-429 Eukaryotic translation initiation factor 2B complex IF-2B complex|eIF-2B complex|eIF2B complex|IF2B complex 559292 P09032(2)|P12754(2)|P14741(2)|P32501(2)|P32502(2) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-11711204 GO:0005851(eukaryotic translation initiation factor 2B complex)|GO:0043547(positive regulation of GTPase activity)|GO:0006446(regulation of translational initiation)|GO:0003743(translation initiation factor activity)|GO:0005085(guanyl-nucleotide exchange factor activity)|GO:0032045(guanyl-nucleotide exchange factor complex) complex portal:CPX-429(complex-primary)|pubmed:24852487(see-also)|pubmed:8506384(see-also)|pubmed:24352424(see-also) Plays a critical regulatory role in eukaryotic translation initiation. Acts as a guanine nucleotide exchange factor (GEF) catalyzing the exchange of GDP on eIF2-GDP for GTP, thus reactivating eIF2 (CPX-427) and allowing subsequent rounds of translation initiation. This activity is inhibited by the when phosphorylated eIF2 (alpha subunit) binds to eIF2B. Phosphorylation of eIF2 occurs in response to nutrient starvation and thus prevents further protein synthesis. eIF2B also acts as a GDP dissociation inhibitor (GDI) displacement factor that can recruit eIF2 from the eIF2.GDP/eIF5 GDI complex prior to GEF action. MW = approx. 600 kD Heterodecamer - - - - - psi-mi:"MI:0469"(IntAct) P09032(2)|P12754(2)|P14741(2)|P32501(2)|P32502(2) +CPX-430 Eukaryotic translation initiation factor 4F complex, variant TIF4631 IF-4F complex|eIF-4F complex|eIF4F complex|IF4F complex 559292 P07260(1)|P10081(1)|P39935(1) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0016281(eukaryotic translation initiation factor 4F complex)|GO:0005524(ATP binding)|GO:0006446(regulation of translational initiation)|GO:0008186(RNA-dependent ATPase activity)|GO:0005840(ribosome)|GO:0000340(RNA 7-methylguanosine cap binding)|GO:0003724(RNA helicase activity)|GO:0003743(translation initiation factor activity) wwpdb:2VSO(subset)|wwpdb:2VSX(subset)|complex portal:CPX-430(complex-primary)|pubmed:14675538(see-also)|pubmed:1502180(see-also)|wwpdb:1rf8(subset)|intenz:3.6.4.13(identity)|pubmed:18606994(see-also) Binds the 5-prime cap of messenger RNAs to recruit mRNA to the ribosome during translation initiation. During cap-dependent translation, eIF4G1 (TIF4631) brings the 5' end of the mRNA in proximity with the helicase eIF4A (TIF1,TIF2) through interactions with eIF4E (CDC33). Facilitates 48S pre-initiation complex formation through interaction with eIF3 (CPX-1831) in the 43S pre-initiation complex. The relatively weak helicase activity of eIF4A is presumed to be required for unwinding mRNA secondary structures. The poly(A) binding protein PAB1 can bind to eIF4G1 act to stimulate cap-dependent translation initiation, even in the absence of a poly(A) tail. - Heterotrimer - - - - - psi-mi:"MI:0469"(IntAct) P07260(1)|P10081(1)|P39935(1) +CPX-431 Eukaryotic translation initiation factor 4F complex, variant TIF4632 IF4F complex|eIF-4F complex|eIF4F complex|IF-4F complex 559292 P07260(1)|P10081(1)|P39936(1) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0005840(ribosome)|GO:0000340(RNA 7-methylguanosine cap binding)|GO:0003724(RNA helicase activity)|GO:0003743(translation initiation factor activity)|GO:0016281(eukaryotic translation initiation factor 4F complex)|GO:0008186(RNA-dependent ATPase activity)|GO:0005524(ATP binding)|GO:0006446(regulation of translational initiation) intenz:3.6.4.13(identity)|complex portal:CPX-431(complex-primary)|pubmed:10409745(see-also)|pubmed:1502180(see-also) Binds the 5-prime cap of messenger RNAs to recruit mRNA to the ribosome during translation initiation. During cap-dependent translation, eIF4G2 (TIF4632) brings the 5' end of the mRNA in proximity with the helicase eIF4A (TIF1,TIF2) through interactions with eIF4E (CDC33). Facilitates 48S pre-initiation complex formation through interaction with eIF3 (CPX-1831) in the 43S pre-initiation complex. The relatively weak helicase activity of eIF4A is presumed to be required for unwinding mRNA secondary structures. The poly(A) binding protein PAB1 can bind to eIF4G2 act to stimulate cap-dependent translation initiation, even in the absence of a poly(A) tail. - Heterotrimer - - - - - psi-mi:"MI:0469"(IntAct) P07260(1)|P10081(1)|P39936(1) +CPX-435 Translation release factor ERF1-ERF3 complex Peptide release factor ERF1-ERF3 559292 CHEBI:15996(1)|P05453(1)|P12385(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-11739934 GO:0005737(cytoplasm)|GO:0003747(translation release factor activity)|GO:0006415(translational termination)|GO:0003924(GTPase activity)|GO:0018444(translation release factor complex) emdb:2597(identity)|complex portal:CPX-435(complex-primary)|wwpdb:4CRN(identity) Required for the termination of protein synthesis which occurs when one of three stop codons (UAA, UAG or UGA) enters the ribosomal A site. ERF1 recognises and binds to a stop codon, the eRF3 GTPase then hydolyses peptidyltransferase RNA before dissociating from the complex. - Heterodimer - - - - - psi-mi:"MI:0469"(IntAct) P05453(1)|P12385(1) +CPX-465 DOM34-HBS1 ribosome dissociation complex - 559292 CHEBI:15996(0)|P32769(1)|P33309(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-2215556 GO:0043022(ribosome binding)|GO:0003924(GTPase activity)|GO:0072344(rescue of stalled ribosome)|GO:0070966(nuclear-transcribed mRNA catabolic process, no-go decay)|GO:0045948(positive regulation of translational initiation)|GO:1990533(Dom34-Hbs1 complex)|GO:0032790(ribosome disassembly) pubmed:11909951(see-also)|pubmed:21623367(see-also)|pubmed:20947765(see-also)|pubmed:24424461(see-also)|wwpdb:3izq(identity)|emdb:1811(identity)|complex portal:CPX-465(complex-primary) Mediates dissociation of inactive 80S ribosomes associated in a non-translating, inactive pool, for example following stress-induced global shut-down of translation. Binds to the ribosomal A site. GTP hydrolysis, dissociation of HBS1 and accommodation of DOM34 in the ribosome, results in the binding of RLI1 (Q03195) followed by ATP-dependent subunit dissociation. Also plays a role in RNA quality control in No-Go decay, releasing ribosomes that are stalled at the 3-prime end of mRNAs lacking a termination codon. - Heterodimer - - - - - psi-mi:"MI:0469"(IntAct) P32769(1)|P33309(1) +CPX-473 TOM40 mitochondrial outer membrane translocase core complex Tom core complex|Mitochondrial outer membrane translocase core complex|GIP complex|General import pore 559292 P23644(2)|P33448(2)|P49334(2)|P53507(3)|P80967(2) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-1180467 GO:0005742(mitochondrial outer membrane translocase complex)|GO:0045040(protein import into mitochondrial outer membrane)|GO:0031307(integral component of mitochondrial outer membrane) complex portal:CPX-473(complex-primary)|pubmed:31740857(see-also)|emdb:EMD-20728(identity)|emdb:EMD-20729(identity)|wwpdb:6UCU(identity)|wwpdb:6UCV(identity)|pubmed:12857785(see-also)|pubmed:17263664(see-also) Core cation-selective high-conductance channel of the mitochondrial outer membrane preprotein translocase, through which nuclear-encoded precursor proteins cross the membrane in an unfolded state. Most mitochondrial proteins are synthesized in the cytosol, imported into mitochondria, sorted to one of the four submitochondrial compartments, where they function, and attain their functional native conformation, which is often facilitated by assembly into the membrane or a multiprotein complex. The existance of this core complex may be an artefact of the purification process but yeast cells lacking the receptor subunits (TOM20 and TOM70) are viable and import proteins at a reduced rate into the mitochondria. The core complex (CPX-473) forms a stable dimer arranged in twofold symmetry. TOM40 appears to form a pore with a highly negatively charged surface, consisting of 19 beta-strands arranged in a largely anti-parallel fashion. The negative charge of this channel may act to attract positively charged polypeptides, such as pre-sequences, to initiate translocation. The dimeric complex may further associate into larger oligomers through lateral stacking. Each TOM40 channel possesses two precursor exit sites. TOM22, TOM40 and TOM7 guide pre-sequence-containing preproteins to the exit in the middle of the dimer, whereas TOM5 and a TOM40 N-terminal extension guide pre-proteins lacking a pre-sequence to the exit at the periphery of the dimer. Heterodecamer - - - - - psi-mi:"MI:0469"(IntAct) P23644(2)|P33448(2)|P49334(2)|P53507(3)|P80967(2) +CPX-474 TOM40 mitochondrial outer membrane translocase holocomplex TOM holocomplex|Mitochondrial outer membrane translocase holocomplex|Preprotein translocase of the outer mitochondrial membrane 559292 P07213(0)|P23644(2)|P33448(2)|P35180(0)|P49334(2)|P53507(2)|P80967(2) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-1180448 GO:0005742(mitochondrial outer membrane translocase complex)|GO:0045040(protein insertion into mitochondrial outer membrane)|GO:0005741(mitochondrial outer membrane) complex portal:CPX-474(complex-primary)|pubmed:31740857(see-also)|wwpdb:6UCU(subset)|wwpdb:6UCV(subset)|emdb:EMD-20728(subset)|emdb:EMD-20729(subset)|pubmed:31600774(see-also)|pubmed:12857785(see-also) Translocase in the outer mitochondrial membrane that mediates the import of precursor protein and mediates inset of some resident outer membrane proteins. Most mitochondrial proteins are synthesized in the cytosol, imported into mitochondria, sorted to one of the four submitochondrial compartments, where they function, and attain their functional native conformation, which is often facilitated by assembly into the membrane or a multiprotein complex. The holo TOM complex contains two or three pores, each of which has a diameter of approximately 20A. When translocation by the TOM complex is coupled with that by the TIM23 or TIM22 complex, the TOM channel can operate as a passive pore to allow passage of the polypeptide segment, which is `pulled' by the TIM complex with the aid of differenial membrane potential and/or ATP. When translocation is uncoupled from the inner-membrane translocators, the TOM complex uses both the stop-transfer pathway, which consists of two steps, the first requiring a membrane potential and an ATP-dependent chaperone mHsp70, and a second mechanism involving the folding of an N-terminal domain that has already crossed the outer membrane and can function as a trap in the intermembrane space to drive translocation of the C-terminal part of the protein by a Brownian ratchet mechanism. The core complex (CPX-473) forms a stable dimer arranged in twofold symmetry. TOM40 forms a pore with a highly negatively charged surface, consisting of 19 beta-strands arranged in a largely anti-parallel fashion. The negative charge of this channel may act to attract positively charged polypeptides, such as pre-sequences, to initiate translocation. The dimeric complex may further associate into larger oligomers through lateral stacking. TOM70 and TOM20 are the import receptors, TOM5 also has a receptor function required for transferring pre-proteins from TOM22 to the TOM40 channel. TOM6 supports the stable interaction of import receptors and the TOM complex and maintains TOM complex integrity whilst TOM7 regulates dissociation of the TOM complex Each TOM40 channel possesses two precursor exit sites. TOM22, TOM40 and TOM7 guide pre-sequence-containing preproteins to the exit in the middle of the dimer, whereas TOM5 and a TOM40 N-terminal extension guide pre-proteins lacking a pre-sequence to the exit at the periphery of the dimer. - - - - - - psi-mi:"MI:0469"(IntAct) P07213(0)|P23644(2)|P33448(2)|P35180(0)|P49334(2)|P53507(2)|P80967(2) +CPX-532 Adaptor complex AP-1 Adapter complex AP-1 559292 P35181(0)|P36000(0)|Q00776(0)|Q12028(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0030121(AP-1 adaptor complex)|GO:0048203(vesicle targeting, trans-Golgi to endosome)|GO:0030276(clathrin binding) complex portal:CPX-532(complex-primary) Plays a central role in clathrin-coated vesicle formation by coupling coat assembly and cargo collection. Binds short linear motifs on cargo proteins and incorporates them into the clathrin coat of forming vesicles. Mediates the bi-directional transfer of membrane proteins between the trans-Golgi network and the early endosome. Related complexes AP-1 and AP-1R (CPX-533) differ only in the mu chain and sort different cargoes: for example, only AP-1 binds and transports chitin synthase 3 (CHS3, P29465) and the salt stress-induced hydrophobic SNA2 protein (P56508). Consists of a core complex with two appendages projecting from the large (L) subunits via flexible linkers which bind a variety of regulatory proteins which may contribute to substrate specificity. - - - - - - psi-mi:"MI:0469"(IntAct) P35181(0)|P36000(0)|Q00776(0)|Q12028(0) +CPX-533 Adaptor complex AP-1R AP-1 Related complex|Adapter complex AP-1R 559292 P35181(0)|P36000(0)|P38700(0)|Q12028(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0030121(AP-1 adaptor complex)|GO:0048203(vesicle targeting, trans-Golgi to endosome)|GO:0030276(clathrin binding) complex portal:CPX-533(complex-primary) Plays a central role in clathrin-coated vesicle formation by coupling coat assembly and cargo collection. Binds short linear motifs on cargo proteins and incorporates them into the clathrin coat of forming vesicles. Mediates the bi-directional transfer of membrane proteins between the trans-Golgi network and the early endosome. Related complexes AP-1 (CPX-532) and AP-1R differ only in the mu chain and sort different cargoes: for example, only AP-1R binds Yfl034w (P43564), a predicted serine hydrolase that is required for APM2-dependent sorting processes and has a role in recruiting APM2 to membranes. Consists of a core complex with two appendages projecting from the large (L) subunits via flexible linkers which bind a variety of regulatory proteins which may contribute to substrate specificity. - - - - - - psi-mi:"MI:0469"(IntAct) P35181(0)|P36000(0)|P38700(0)|Q12028(0) +CPX-534 Adapter complex AP-2 AP-2R complex 559292 P27351(0)|P38065(0)|Q00381(0)|Q99186(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0006886(intracellular protein transport)|GO:0030122(AP-2 adaptor complex) complex portal:CPX-534(complex-primary) Probably acts in a clathrin-independent protein sorting pathway. Found at the plasma membrane. By similarity to AP-1 (CPX-532), consists of a core complex with two appendages projecting from the large (L) subunits via flexible linkers which bind a variety of regulatory proteins which may contribute to substrate specificity. - - - - - - psi-mi:"MI:0469"(IntAct) P27351(0)|P38065(0)|Q00381(0)|Q99186(0) +CPX-535 Adapter complex AP-3 - 559292 P38153(0)|P46682(0)|P47064(0)|Q08951(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0006886(intracellular protein transport)|GO:0030123(AP-3 adaptor complex)|GO:0006896(Golgi to vacuole transport) complex portal:CPX-535(complex-primary) Probably acts in clathrin-independent traffic of membrane proteins from the Golgi apparatus to vacuoles. By similarity to AP-1 (CPX-532), consists of a core complex with two appendages projecting from the large (L) subunits via flexible linkers which bind a variety of regulatory proteins which may contribute to substrate specificity. - - - - - - psi-mi:"MI:0469"(IntAct) P38153(0)|P46682(0)|P47064(0)|Q08951(0) +CPX-536 cAMP-dependent protein kinase complex variant 1 PKA complex|cyclic AMP-dependent protein kinase complex 559292 P06244(2)|P07278(2) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0005952(cAMP-dependent protein kinase complex)|GO:0008603(cAMP-dependent protein kinase regulator activity) pubmed:3037314(see-also)|complex portal:CPX-536(complex-primary) Inactive form of the cAMP-dependent protein kinase which assembles when cAMP concentrations are low. Exists as a tetramer composed of two catalytic subunits and two regulatory subunits. When cAMP concentrations are high, the nucleotide binds to the inhibitory BCY1 subunits, causing dissociation from, and activation of, the catalytic subunits. - - - - - - - psi-mi:"MI:0469"(IntAct) P06244(2)|P07278(2) +CPX-537 cAMP-dependent protein kinase complex variant 2 PKA complex|cyclic AMP-dependent protein kinase complex 559292 P06245(2)|P07278(2) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0008603(cAMP-dependent protein kinase regulator activity)|GO:0005952(cAMP-dependent protein kinase complex) complex portal:CPX-537(complex-primary)|pubmed:3037314(see-also) Inactive form of the cAMP-dependent protein kinase which assembles when cAMP concentrations are low. Exists as a tetramer composed of two catalytic subunits and two regulatory subunits. When cAMP concentrations are high, the nucleotide binds to the inhibitory BCY1 subunits, causing dissociation from and activation of the catalytic subunits. - - - - - - - psi-mi:"MI:0469"(IntAct) P06245(2)|P07278(2) +CPX-544 PCNA homotrimer PCNA complex|Proliferating Cell Nuclear Antigen complex|Proliferating Cell Nuclear Antigen 559292 P15873(3) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-1208731 GO:0045739(positive regulation of DNA repair)|GO:0045740(positive regulation of DNA replication)|GO:0043626(PCNA complex)|GO:0030337(DNA polymerase processivity factor activity)|GO:0003677(DNA binding)|GO:0005634(nucleus) complex portal:CPX-544(complex-primary)|wwpdb:1PLR(identity)|wwpdb:1PLQ(identity)|pubmed:15210332(see-also) Role in DNA replication, repair, cell-cycle control, and chromatin remodeling. Exists as a double back-to-back homotrimeric ring which encircles double-stranded DNA and slides spontaneously across it. Loaded onto at template-primer junctions synthesized on unwound DNA during S phase in an ATP-dependent process by replication factor C (CPX-545), where it recruits replicative DNA polymerases and stimulates their activity. The process of chromatin assembly is tightly coupled to DNA replication or repair and the double homotrimer allows DNA polymerase delta to binds to one homotrimer whilst the chromatin assembly factor-1 CNOT7 binds to the other. M.W = 100kDa (homotrimer), the double homotrimer = 200kDa. The inner cavity of the protein ring has a diameter of about 30 A. The inner surface of the ring has a positive electrostatic potential with as many as 10 positively charged amino acids per subunit protruding from alpha helices inward into the central cavity. Homotrimer - - - - - psi-mi:"MI:0469"(IntAct) P15873(3) +CPX-545 DNA replication factor C complex RFC|RFC complex|Activator 1 complex|RFC Heteropentamer 559292 P38251(1)|P38629(1)|P38630(1)|P40339(1)|P40348(1) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0005663(DNA replication factor C complex)|GO:0005524(ATP binding)|GO:0006261(DNA-dependent DNA replication)|GO:0003689(DNA clamp loader activity)|GO:0003677(DNA binding) complex portal:CPX-545(complex-primary)|pubmed:15952889(see-also) DNA-dependent ATPase that functions with PCNA (CPX-544) to confer processivity on DNA polymerase delta. RFC uses the energy of ATP binding and hydrolysis to recruit PCNA to DNA, break one clamp interface, and topologically link the clamp to primed template DNA during the duplication of chromosomal DNA prior to cell division. After loading PCNA, RFC then dissociates, allowing PCNA to function with Pol-delta RFC consists of five subunits in a spiral arrangement, each subunit being AAA+ family proteins, and the complex contains four ATP sites located at subunit interfaces. A cavity exists in the center of this protein spiral that accommodates double-stranded DNA. Conserved polar and positively charged residues line the cavity and interact with DNA. There is a gap between two subunits, RFC1 and RFC5, which may provide an exit path for single-stranded DNA from the central cavity. - Heteropentamer - - - - - psi-mi:"MI:0469"(IntAct) P38251(1)|P38629(1)|P38630(1)|P40339(1)|P40348(1) +CPX-548 NDC80 complex Tid3 complex|Nuf2-Ndc80 complex|NDC80-NUF2-SPC24-SPC25 complex 559292 P33895(0)|P40014(0)|P40460(0)|Q04477(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-1001934 GO:0031262(Ndc80 complex)|GO:0007059(chromosome segregation)|GO:0008608(attachment of spindle microtubules to kinetochore)|GO:0090266(regulation of mitotic cell cycle spindle assembly checkpoint) wwpdb:2ftx(subset)|wwpdb:2FV4(subset)|complex portal:CPX-548(complex-primary)|pubmed:15661517(see-also)|pubmed:15509863(see-also)|pubmed:12925767(see-also) Crucial for the stable kinetochore-microtubule attachments that are needed to sustain the centromere tensions involved in achieving proper chromosome alignment in eukaryotic cells, with a role in chromosome alignment and microtubule-dependent control of MAD1/MAD2 and dynein complexes at kinetochores. Loss-of-function mutation of any of 4 subunits in yeast causes disrupted kinetochore-microtubule binding and inactivation of the spindle checkpoint, leading to high rate of chromosome loss. Ndc80 complex is rod-like with a globular head at each end. NDC80 and NUF2 form one head and part of rod and SPC24 and SPC25 form rest of rod and other head. SPC24 and SPC25 fold tightly together into a single globular entity. SPC24/SPC25 end of the complex appears to point to the centromere, and the NDC80/NUF2 end to the microtubule. MW=175 kDa (estimated for recombinant NDC80 complex) - - - - - - psi-mi:"MI:0469"(IntAct) P33895(0)|P40014(0)|P40460(0)|Q04477(0) +CPX-554 6-phosphofructokinase complex 6-phosphofructokinase|phosphofructokinase|phosphohexokinase|6PF-1-K complex|Pfk-1 complex|PFK complex 559292 P16861(4)|P16862(4) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-1212520 GO:0006002(fructose 6-phosphate metabolic process)|GO:0006096(glycolytic process)|GO:0003872(6-phosphofructokinase activity)|GO:0005945(6-phosphofructokinase complex)|GO:0070095(fructose-6-phosphate binding) complex portal:CPX-554(complex-primary)|intenz:2.7.1.11(identity)|pubmed:11015725(see-also)|wwpdb:3o8o(identity) Catalyzes the phosphorylation of fructose 6-phosphate to fructose 1,6-bisphosphate in the presence of MgATP, the first irreversible step for glycolysis. The enzyme is stablilized in the presence of Fructose 6-P and exhibits cooperative binding of Fructose 6-P. Its activity is controlled by many allosteric activators and inhibitors (including ATP), showing its crucial role in regulation of glycolytic flux. The enzyme can exist in either the active R-state or inhibited T-state. The effectors either modulate the affinity of Pfk for Fructose 6-P or overcome inhibitory effects. Pfk is an octamer composed of 4 alpha and 4 beta subunits. MW = 835 kDA (approximately). Each subunit is approximately 105 kDa. The native octameric structure has a sedimentation coefficient of 21 S. The molecule is elongated with length of 24 nm and width of 17 nm. There is mild asymmetry between the top and bottom tetramers, each composed of 2 alpha and 2 beta subunits. Heterooctamer - - - - - psi-mi:"MI:0469"(IntAct) P16861(4)|P16862(4) +CPX-558 Mitochondrial isocitrate dehydrogenase complex (NAD+) Isocitrate dehydrogenase (NAD+) holoenzyme|NAD-dependent isocitrate dehydrogenase|Isocitrate dehydrogenase holoenzyme|threo-Ds-isocitrate:NAD+ oxidoreductase (decarboxylating)|IDH|beta-ketoglutaric-isocitric carboxylase|nicotinamide adenine dinucleotide isocitrate dehydrogenase|NAD isocitrate dehydrogenase|NAD isocitric dehydrogenase|NAD-linked isocitrate dehydrogenase|NAD-specific isocitrate dehydrogenase|isocitric acid dehydrogenase|isocitric dehydrogenase 559292 CHEBI:60240(8)|P28241(4)|P28834(4) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-2321742 GO:0003729(mRNA binding)|GO:0004449(isocitrate dehydrogenase (NAD+) activity)|GO:0005962(mitochondrial isocitrate dehydrogenase complex (NAD+))|GO:0006099(tricarboxylic acid cycle)|GO:0005739(mitochondrion) complex portal:CPX-558(complex-primary)|pubmed:18256028(see-also)|wwpdb:3blv(identity)|wwpdb:3blx(identity)|wwpdb:3blw(identity)|intenz:1.1.1.41(identity)|pubmed:16342968(see-also)|protein ontology:PR:000026166(identity) A tricarboxylic acid cycle enzyme which catalyzes the conversion of threo-Ds-isocitrate to alpha-ketoglutarate and carbon dioxide, important for regulatory control of mitochondrial energy metabolism. Allosterically regulated, activated by citrate and ADP, inhibited by ATP and NADH. Binds specifically and with high affinity to 5'-untranslated regions of yeast mitochondrial mRNAs. - Heterooctamer - - - - - psi-mi:"MI:0469"(IntAct) P28241(4)|P28834(4) +CPX-565 Mitochondrial respiratory chain complex II Succinate dehydrogenase complex|Succinate dehydrogenase (ubiquinone)|Respiratory chain complex II|Complex II|succinate:ubiquinone oxidoreductase|CII|SQR|Fumarate reductase complex|Menaquinol: fumarate oxidoreductase|Succinic dehydrogenase 559292 CHEBI:16238(1)|CHEBI:21137(1)|CHEBI:30413(1)|CHEBI:49601(1)|CHEBI:49883(1)|P21801(1)|P33421(1)|P37298(1)|Q00711(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-1224294 GO:0008177(succinate dehydrogenase (ubiquinone) activity)|GO:0005749(mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone))|GO:0006099(tricarboxylic acid cycle)|GO:0042776(mitochondrial ATP synthesis coupled proton transport)|GO:0006121(mitochondrial electron transport, succinate to ubiquinone)|GO:0031305(integral component of mitochondrial inner membrane) complex portal:CPX-565(complex-primary)|rhea:RHEA:40523(identity)|pubmed:11803020(see-also)|intenz:1.3.5.1(identity) Key role in aerobic respiration, in which mitochondrial enzymes accept electrons from electron carriers reduced in glycolysis and the tricarboxylic acid cycle. Catalyzes the oxidation of succinate to fumarate as part of tricarboxylic acid cycle and and transfers the electrons to coenzyme Q of the respiratory chain to form ubiquinol. Under most conditions the electrons are used to reduce oxygen, allowing ATP synthesis. SDH1 and SDH2 form the catalytic dimer that is anchored to the matrix surface of the mitochondrial inner membrane by SDH3 and SDH4, integral membrane proteins of the membrane dimer. Electrons flow from succinate to the FAD, and sequentially through the [2Fe:2S], the [4Fe:4S], and the [3Fe:4S] clusters. From there, electrons enter the membrane dimer which contains a b-type heme and the active site for ubiquinone reduction. - Heterotetramer - - - - - psi-mi:"MI:0469"(IntAct) P21801(1)|P33421(1)|P37298(1)|Q00711(1) +CPX-567 Mitochondrial respiratory chain complex III Ubiquinol-cytochrome c reductase complex|b6/f complex|bc1 complex|coenzyme Q-cytochrome c reductase|coenzyme QH2-cytochrome c reductase|complex III|coQH2-cytochrome c oxidoreductase|cyt bc1|Cyt bc1 complex|cytochrome b-c1 complex|cytochrome b-c2 complex|cytochrome bc1 complex|dihydrocoenzyme Q-cytochrome c reductase|f-b6 complex|hydroubiquinone c2 oxidoreductase|plastoquinol-plastocyanin oxidoreductase|QCR|QH2:cytochrome c oxidoreductase|quinol cyt. c oxidoreductase (bc1)|quinol-cytochrome c oxidoreductase complex|reduced coenzyme Q-cytochrome c reductase|reduced ubiquinone-cytochrome c oxidoreductase|reduced ubiquinone-cytochrome c reductase|complex III (mitochondrial electron transport)|respiratory complex III|ubihydroquinol:cytochrome c oxidoreductase|ubiquinol-cytochrome c oxidoreductase|ubiquinol-cytochrome c reductase|ubiquinol-cytochrome c reductase complex|ubiquinol-cytochrome c-2 oxidoreductase|ubiquinol-cytochrome c1 oxidoreductase|ubiquinol-cytochrome c2 reductase|ubiquinol:cytochrome c reductase|ubiquinol:ferricytochrome c oxidoreductase|ubiquinone-cytochrome b-c1 oxidoreductase|ubiquinone-cytochrome c oxidoreductase|ubiquinone-cytochrome c reductase|Q-cytochrome c oxidoreductase|Mitochondrial electron transport complex III 559292 CHEBI:30413(1)|CHEBI:49601(1)|P00127(1)|P00128(1)|P00163(1)|P07143(1)|P07256(1)|P07257(1)|P08067(1)|P08525(1)|P22289(1)|P37299(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-1224354 GO:0005750(mitochondrial respiratory chain complex III)|GO:0008121(ubiquinol-cytochrome-c reductase activity)|GO:0031305(integral component of mitochondrial inner membrane)|GO:0006122(mitochondrial electron transport, ubiquinol to cytochrome c)|GO:0009055(electron transfer activity)|GO:0045333(cellular respiration) complex portal:CPX-567(complex-primary)|rhea:RHEA:11484(identity)|wwpdb:1p84(subset)|wwpdb:3cx5(subset)|wwpdb:3cxh(subset)|intenz:1.10.2.2(identity)|pubmed:16937356(see-also)|wwpdb:1KYO(identity)|pubmed:10066163(see-also) Key role in aerobic respiration, in which mitochondrial enzymes accept electrons from electron carriers reduced in glycolysis and the tricarboxylic acid cycle. Ubiquinol-cytochrome c reductase pumps protons into the intermembrane space, creating an electrochemical gradient. This is achieved by oxidizing ubiquinol (ubihydroquinone) which reacts from the membrane phase, reducing cytochrome c in the intermembrane space, and using the free energy change to transport H+ ions across the membrane from the matrix to the inter membrane space. Quinol oxidation occurs in a bifurcated reaction, in which one electron is transferred to a high potential chain and the other to a low potential chain. The high potential chain, consisting of the iron sulfur protein, cyt c1 and cyt c2, transfers the first electron from quinol to an acceptor (cytochrome oxidase). The low potential chain consists of two cyt b hemes, which serve as a pathway through which electrons are transferred across the coupling membrane. The whole complex is believed to act as a dimer which binds to a single molecule of cytochrome C. Decamer - - - - - psi-mi:"MI:0469"(IntAct) P00127(1)|P00128(1)|P00163(1)|P07143(1)|P07256(1)|P07257(1)|P08067(1)|P08525(1)|P22289(1)|P37299(1) +CPX-568 Chromatin assembly factor 1 complex CAF-1|CAF1|CAC1:CAC2:CAC3|CAC1:CAC2:MSI1 559292 P13712(1)|Q04199(1)|Q12495(1) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0006335(DNA replication-dependent chromatin assembly)|GO:0033186(CAF-1 complex)|GO:0031493(nucleosomal histone binding)|GO:0031497(chromatin assembly)|GO:0006260(DNA replication)|GO:0006281(DNA repair) complex portal:CPX-568(complex-primary)|pubmed:30239791(see-also)|pubmed:10322140(see-also)|pubmed:14519857(see-also)|pubmed:15542829(see-also)|pubmed:16143623(see-also) Catalyzes de novo assembly of nucleosomes onto newly synthesized DNA, involved in chromatin assembly following both DNA replication and some forms of DNA repair. Binds modified histones H3 and H4 and deposits them as a tetramer, preferentially onto replicating DNA, in a step coupled to the replication process. This is followed by deposition of a pair of dimers of histones H2A and H2B mediated by other factor(s) in a process not necessarily coupled to DNA replication. The histone core of nucleosomes consists of two copies of each of histones H2A, H2B, H3 and H4. CAF-1 nucleosome deposition is thought to be involved in heterochromatic silencing. CAF-1 is not required for yeast cell proliferation, suggesting other pathway(s) can compensate. - Heterotrimer - - - - - psi-mi:"MI:0469"(IntAct) P13712(1)|Q04199(1)|Q12495(1) +CPX-571 cAMP-dependent protein kinase complex variant 3 cyclic AMP-dependent protein kinase complex|PKA complex 559292 P05986(2)|P07278(2) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0008603(cAMP-dependent protein kinase regulator activity)|GO:0005952(cAMP-dependent protein kinase complex) complex portal:CPX-571(complex-primary)|pubmed:3037314(see-also) Inactive form of the cAMP-dependent protein kinase which assembles when cAMP concentrations are low. Exists as a tetramer composed of two catalytic subunits and two regulatory subunits. When cAMP concentrations are high, the nucleotide binds to the inhibitory BCY1 subunits, causing dissociation from and activation of the catalytic subunits. - - - - - - - psi-mi:"MI:0469"(IntAct) P05986(2)|P07278(2) +CPX-572 cAMP-dependent protein kinase complex variant 4 PKA complex|cyclic AMP-dependent protein kinase complex 559292 P06244(1)|P06245(1)|P07278(2) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0008603(cAMP-dependent protein kinase regulator activity)|GO:0005952(cAMP-dependent protein kinase complex) complex portal:CPX-572(complex-primary)|pubmed:3037314(see-also) Inactive form of the cAMP-dependent protein kinase which assembles when cAMP concentrations are low. Exists as a tetramer composed of two catalytic subunits and two regulatory subunits. When cAMP concentrations are high, the nucleotide binds to the inhibitory BCY1 subunits, causing dissociation from and activation of the catalytic subunits. - - - - - - - psi-mi:"MI:0469"(IntAct) P06244(1)|P06245(1)|P07278(2) +CPX-573 cAMP-dependent protein kinase complex variant 5 PKA complex|cyclic AMP-dependent protein kinase complex 559292 P05986(1)|P06244(1)|P07278(2) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0008603(cAMP-dependent protein kinase regulator activity)|GO:0005952(cAMP-dependent protein kinase complex) pubmed:3037314(see-also)|complex portal:CPX-573(complex-primary) Inactive form of the cAMP-dependent protein kinase which assembles when cAMP concentrations are low. Exists as a tetramer composed of two catalytic subunits and two regulatory subunits. When cAMP concentrations are high, the nucleotide binds to the inhibitory BCY1 subunits, causing dissociation from and activation of the catalytic subunits. - - - - - - - psi-mi:"MI:0469"(IntAct) P05986(1)|P06244(1)|P07278(2) +CPX-574 cAMP-dependent protein kinase complex variant 6 PKA complex|cyclic AMP-dependent protein kinase complex 559292 P05986(1)|P06245(1)|P07278(2) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0008603(cAMP-dependent protein kinase regulator activity)|GO:0005952(cAMP-dependent protein kinase complex) pubmed:3037314(see-also)|complex portal:CPX-574(complex-primary) Inactive form of the cAMP-dependent protein kinase which assembles when cAMP concentrations are low. Exists as a tetramer composed of two catalytic subunits and two regulatory subunits. When cAMP concentrations are high, the nucleotide binds to the inhibitory BCY1 subunits, causing dissociation from and activation of the catalytic subunits. - - - - - - - psi-mi:"MI:0469"(IntAct) P05986(1)|P06245(1)|P07278(2) +CPX-575 Ste12/Dig1/Dig2 transcription regulation complex - 559292 P13574(0)|Q03063(0)|Q03373(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-12498149 GO:0000977(RNA polymerase II regulatory region sequence-specific DNA binding)|GO:1990526(Ste12p-Dig1p-Dig2p complex)|GO:0046020(negative regulation of transcription from RNA polymerase II promoter by pheromones)|GO:0045894(negative regulation of mating-type specific transcription, DNA-templated) complex portal:CPX-575(complex-primary) Translational repressor complex which binds to the pheromone response elements (PREs; TGAAACR) in mating gene promoters. Upon pheromone stimulation, Fus3 MAPK (P16892) phosphorylates members of the Ste12 complex leading to dissociation and/or conformational change of the complex and to relief of Ste12 repression. - - - - - - - psi-mi:"MI:0469"(IntAct) P13574(0)|Q03063(0)|Q03373(0) +CPX-576 Tec1/Ste12/Dig1 transcription regulation complex Ste12/Tec1/Dig1 complex 559292 P13574(0)|P18412(0)|Q03063(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-12498132 GO:0010570(regulation of filamentous growth)|GO:0000977(RNA polymerase II regulatory region sequence-specific DNA binding)|GO:0000122(negative regulation of transcription from RNA polymerase II promoter)|GO:1990527(Tec1p-Ste12p-Dig1p complex) complex portal:CPX-576(complex-primary) Translational repressor complex which binds to the filamentation response elements (FREs) on filamentous growth-specific target genes and, at much lower levels, at the pheremone response elements (PREs) of mating genes. Upon pheromone stimulation, Fus3 MAPK (P16892) phosphorylates members of the Ste12 complex leading to dissociation and/or conformational change of the complex and to relief of Ste12 repression. - - - - - - - psi-mi:"MI:0469"(IntAct) P13574(0)|P18412(0)|Q03063(0) +CPX-579 Carbamoyl-phosphate synthase arginine-specific carbamoyl-phosphate synthase (glutamine-hydrolysing)|carbamoyl-phosphate synthetase (glutamine-hydrolysing)|carbamoylphosphate synthetase II|carbamyl phosphate synthetase (glutamine)|glutamine-dependent carbamyl phosphate synthetase|GD-CPSase|glutamine-dependent carbamoyl-phosphate synthase|carbamoyl phosphate synthetase|CPS|CPS-A|carbon-dioxide::L-glutamine amido-ligase (ADP-forming, carbamate-phosphorylating)|CPSase A|arginine pathway carbamoylphosphate synthase|carbamoyl-phosphate synthase arginine-specific|hydrogen-carbonate:L-glutamine amido-ligase (ADP-forming, carbamate-phosphorylating)|CARA-CARB complex 559292 P03965(1)|P07258(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-811850 GO:0004088(carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity)|GO:0005951(carbamoyl-phosphate synthase complex)|GO:0006221(pyrimidine nucleotide biosynthetic process)|GO:0006526(arginine biosynthetic process)|GO:0005524(ATP binding)|GO:0005737(cytoplasm) complex portal:CPX-579(complex-primary)|pubmed:8626695(see-also)|pubmed:206535(see-also)|intenz:6.3.5.5(identity) Carbamoyl-phosphate synthase is a heterodimer consisting in the CPA1 and CPA2 subunits. CPS catalyzes the formation of carbamoyl phosphate from the ammonia moiety of glutamine, carbonate, and phosphate donated by ATP, as the first step in biosynthetic pathway leading to formation of arginine and/or urea. The small subunit (glutamine amidotransferase) binds and cleaves glutamine and the large subunit (synthetase) accepts the ammonia moiety cleaved from glutamine, binds all of the remaining substrates, and carries out all of the other catalytic events. MW =140, 000 (7.9S) (estimated by sucrose gradient centrifugation); MW = 175, 000 (by gel filtration). CPA1 subunit is 45 kDa and MW= 36, 000 (by gel filtration). CPA2 subunit is 124 kDa and MW= 130, 000 (by gel filtration) . The apparent Michaelis constant at pH 7.5 is 1.25 mM for glutamine. Heterodimer - - - - - psi-mi:"MI:0469"(IntAct) P03965(1)|P07258(1) +CPX-580 mRNA cap methyltransferase complex mRNA guanylyltransferase heterotrimer|mRNA capping enzyme|Protein lambda2|messenger RNA guanylyltransferase|GTP:mRNA guanylyltransferase.|CET1-MCE1 complex 559292 O13297(2)|Q01159(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-1248636 GO:0031533(mRNA cap methyltransferase complex)|GO:0004484(mRNA guanylyltransferase activity)|GO:0006370(7-methylguanosine mRNA capping)|GO:0005525(GTP binding)|GO:0004088(carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity) complex portal:CPX-580(complex-primary)|intenz:2.7.7.50(identity)|pubmed:15718140(see-also)|intenz:3.1.3.33(identity)|wwpdb:3kyh(identity) Catalyzes the first step in mRNA cap formation. Consists of two subunits: an RNA 5'-triphosphatase (RTPase) and GTP:mRNA guanylyltransferase (GTase). The GTase subunit (Ceg1) binds to the phosphorylated carboxyl-terminal domain of the largest subunit (CTD-P) of RNA polymerase II, coupling capping with transcription. The subunits form a dimeric structure with 2 parallel tunnels, having at centre charged and hydrophilic side chains that bind a manganese ion and a sulfate ion. Ceg1 bound to the CTD-P is inactive unless allosterically activated by interaction with the RTPase subunit (Cet1). Cet1 removes the gamma-phosphate from the 5' end of the RNA substrate to leave a diphosphate end. Ceg1 subsequently transfers the GMP moiety of GTP to the 5' end of RNA via an enzyme-GMP covalent reaction intermediate to form the structure GpppN1-. - Heterotrimer - - - - - psi-mi:"MI:0469"(IntAct) O13297(2)|Q01159(1) +CPX-581 Protein kinase CK2 variant 1 CK2|CK-2|CKII|casein kinase 2|casein kinase II|CSK21-CSK22-CSK2B-CSK2C complex 559292 P15790(1)|P19454(1)|P38930(1)|P43639(1) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0005525(GTP binding)|GO:0005524(ATP binding)|GO:0006468(protein phosphorylation)|GO:0051726(regulation of cell cycle)|GO:0004674(protein serine/threonine kinase activity)|GO:0005956(protein kinase CK2 complex) pubmed:16265593(see-also)|complex portal:CPX-581(complex-primary)|pubmed:7592778(see-also)|pubmed:12396231(see-also)|intenz:2.7.11.1(identity)|pubmed:16607517(see-also) CK2 is involved in regulation of cell cycle progression, presumably through phosphorylation of target proteins. CK2 may also have role(s) in inhibiting apoptosis. Phosphorylates serine or threonine residues proximal to acidic amino acids (consensus Ser-Xaa-Xaa-Acidic where acidic residue may be Glu, Asp, pSer or pTYr). Thought to be a dual-specificity kinase in yeast, also able to phosphorylate tyrosine residues, although with less favourable kinetic parameters. ATP or GTP can serve as a phosphate donor. Disruption of CKA1 or CKA2 is not lethal, but disruption of both is synthetic lethal. CKA1 and CKA2 functional overlap is not complete, as yeast with temperature sensitive alleles of CKA1 or CKA2 display distinct phenotypes and different combinations of CKA subunits affect substrate specificity and sub-cellular localization. Disruption of CKB1 or CKB2 causes sensitivity to NaCl and LiCl. Disruption of both CKB1 and CKB2 is not synthetic lethal, although the regulatory subunits are responsible for the structural integrity of the holoenzyme. Much of CK2B is phosphorylated on autophosphorylation site and also in a cell cycle-dependent manner. Km for ATP=7.5uM, KM for GTP=52uM. MW = 150,000 Da.CK2 isoenzymes composed of catalytic alpha and/or alpha-prime subunits with homodimers of regulatory beta2 or beta-prime2 subunits are apparently not formed. Heterotetramer - - - - - psi-mi:"MI:0469"(IntAct) P15790(1)|P19454(1)|P38930(1)|P43639(1) +CPX-582 Trehalose-6-phosphate synthase/phosphatase complex, tps3 variant Trehalose synthase complex|Trehalose-6-phosphate synthase/phosphatase complex|TSP/TPP|alpha,alpha-trehalose-phosphate synthase [UDP-forming]/trehalose-6-phosphate synthase|UDPG-dependent trehalose synthase-phosphatase complex. 559292 P31688(0)|P38426(0)|Q00764(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0003825(alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity)|GO:0004805(trehalose-phosphatase activity)|GO:0005992(trehalose biosynthetic process)|GO:0005946(alpha,alpha-trehalose-phosphate synthase complex (UDP-forming))|GO:0070413(trehalose metabolism in response to stress) complex portal:CPX-582(complex-primary)|rhea:RHEA:18889(identity)|rhea:RHEA:23420(identity)|intenz:3.1.3.12(identity)|intenz:2.4.1.15(identity) Catalyzes the production of trehalose from glucose-6-phosphate and UDP-glucose in a two step process. The Tps1 subunit is a trehalose-6-phosphate synthase (TPS) and catalyses the production of alpha,alpha-trehalose 6-phosphate from UDP-glucose and D-glucose 6-phosphate. Tps2 acts as a trehalose-6-phosphate phosphatase (TPP) to release trehalose as a final product. Tsp3 is a regulatory subunit appearing to be phosphorylated by PKA during stress recovery. MW = 600-800 kDa. This suggests at least one of the subunits may be present in multiple copies. - - - - - - psi-mi:"MI:0469"(IntAct) P31688(0)|P38426(0)|Q00764(0) +CPX-583 Trehalose-6-phosphate synthase/phosphatase complex, tsl1 variant Trehalose synthase complex|Trehalose-6-phosphate synthase/phosphatase complex|TSP/TPP|alpha,alpha-trehalose-phosphate synthase [UDP-forming]/trehalose-6-phosphate synthase|UDPG-dependent trehalose synthase-phosphatase complex. 559292 P31688(0)|P38427(0)|Q00764(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-1248830 GO:0003825(alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity)|GO:0004805(trehalose-phosphatase activity)|GO:0005946(alpha,alpha-trehalose-phosphate synthase complex (UDP-forming))|GO:0070413(trehalose metabolism in response to stress)|GO:0005992(trehalose biosynthetic process) complex portal:CPX-583(complex-primary)|rhea:RHEA:18889(identity)|rhea:RHEA:23420(identity)|intenz:3.1.3.12(identity)|intenz:2.4.1.15(identity) Catalyzes the production of trehalose from glucose-6-phosphate and UDP-glucose in a two step process. The Tps1 subunit is a trehalose-6-phosphate synthase (TPS) and catalyses the production of alpha,alpha-trehalose 6-phosphate from UDP-glucose and D-glucose 6-phosphate. Tps2 acts as a trehalose-6-phosphate phosphatase (TPP) to release trehalose as a final product. Tsl1 is a regulatory subunit and may act to stabilize the complex. MW = 600-800 kDa. This suggests at least one of the subunits may be present in multiple copies. - - - - - - psi-mi:"MI:0469"(IntAct) P31688(0)|P38427(0)|Q00764(0) +CPX-588 Calcineurin complex variant 1 calcineurin|phosphatase 2B|protein phosphatase-2B|serine/threonine-protein phosphatase 2B|PP2B|protein phosphatase 3|PP3|PP2B1-CANB complex 559292 CHEBI:29034(1)|CHEBI:29105(1)|P23287(1)|P25296(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-7972965 GO:0033192(calmodulin-dependent protein phosphatase activity)|GO:0005516(calmodulin binding)|GO:0005509(calcium ion binding)|GO:0005955(calcineurin complex)|GO:0006873(cellular ion homeostasis)|GO:0022604(regulation of cell morphogenesis)|GO:0045893(positive regulation of transcription, DNA-templated) complex portal:CPX-588(complex-primary)|rhea:RHEA:20629(identity)|intenz:3.1.3.16(identity)|pubmed:12725927(see-also)|pubmed:11015619(see-also)|pubmed:12325122(see-also)|pubmed:14623300(see-also) A Ca2+/calmodulin-regulated Ser/Thr protein phosphatase, highly conserved through evolution and a critical component of Ca2+-regulated signaling in a wide range of unicellular and multicellular eukaryotes. Calcineurin is a heterodimer containing a catalytic (A) subunit complexed with an essential regulatory (B) subunit. Calcineurin function requires interaction of both subunits. The catalytic subunit contains an active site dinuclear metal center. The regulatory subunit is tightly associated, myristoylated and binds Ca2+ via four Ca2+-binding EF-hand motifs. Two redundant genes, CNA1 and CNA2, encode the catalytic subunit and their expression is regulated in a cell cycle-dependent manner. In the yeast, Ca2+ signaling mediated by calcineurin, is required for survival during environmental stress. One role of the phosphatase under these conditions is to activate gene expression through its regulation of the CRZ1 (P53968) transcription factor. Calcineurin controls many other physiological processes in yeast, including cell cycle progression, cation homeostasis, morphogenesis, establishment of cell polarity and regulation of cell wall biosynthesis. Cells deficient for calcineurin are unable to survive pheromone-induced G1 arrest. When mobilization of internal calcium stores occurs, the catalytic subunit is bound by Ca2+-calmodulin and the active site is freed by displacement of the autoinhibitory domain. CNA1 and CNA2 are translated into proteins with predicted molecular masses of 63 and 68 kDa. Heterodimer - - - - - psi-mi:"MI:0469"(IntAct) P23287(1)|P25296(1) +CPX-590 Calcineurin complex variant 2 calcineurin|phosphatase 2B|protein phosphatase-2B|serine/threonine-protein phosphatase 2B|PP2B|PP3|protein phosphatase 3|PP2B2-CANB complex 559292 CHEBI:29034(1)|CHEBI:29105(1)|P14747(1)|P25296(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-7973396 GO:0005955(calcineurin complex)|GO:0005509(calcium ion binding)|GO:0005516(calmodulin binding)|GO:0006873(cellular ion homeostasis)|GO:0022604(regulation of cell morphogenesis)|GO:0033192(calmodulin-dependent protein phosphatase activity)|GO:0045893(positive regulation of transcription, DNA-templated) complex portal:CPX-590(complex-primary)|rhea:RHEA:20629(identity)|intenz:3.1.3.16(identity)|pubmed:12725927(see-also)|pubmed:11015619(see-also)|pubmed:12325122(see-also)|pubmed:14623300(see-also) A Ca2+/calmodulin-regulated Ser/Thr protein phosphatase, highly conserved through evolution and a critical component of Ca2+-regulated signaling in a wide range of unicellular and multicellular eukaryotes. Calcineurin is a heterodimer containing a catalytic (A) subunit complexed with an essential regulatory (B) subunit. Calcineurin function requires interaction of both subunits. The catalytic subunit contains an active site dinuclear metal center. The regulatory subunit is tightly associated, myristoylated and binds Ca2+ via four Ca2+-binding EF-hand motifs. Two redundant genes, CNA1 and CNA2, encode the catalytic subunit and their expression is regulated in a cell cycle-dependent manner. In the yeast, Ca2+ signaling mediated by calcineurin, is required for survival during environmental stress. One role of the phosphatase under these conditions is to activate gene expression through its regulation of the CRZ1 (P53968) transcription factor. Calcineurin controls many other physiological processes in yeast, including cell cycle progression, cation homeostasis, morphogenesis, establishment of cell polarity and regulation of cell wall biosynthesis. Cells deficient for calcineurin are unable to survive pheromone-induced G1 arrest. When mobilization of internal calcium stores occurs, the catalytic subunit is bound by Ca2+-calmodulin and the active site is freed by displacement of the autoinhibitory domain. CNA1 and CNA2 are translated into proteins with predicted molecular masses of 63 and 68 kDa. The CNB1 subunit has molecular mass 19-20 kDa. The enzyme cofactors are Fe3+ and Zn2+. Heterodimer - - - - - psi-mi:"MI:0469"(IntAct) P14747(1)|P25296(1) +CPX-599 Nuclear/nucleolar exosome complex, DIS3-RRP6 variant - 559292 CHEBI:18420(4)|P25359(1)|P38792(1)|P46948(1)|P48240(1)|P53256(1)|P53859(1)|Q05636(1)|Q08162(1)|Q08285(1)|Q12149(1)|Q12277(1) ECO:0000353(physical interaction evidence used in manual assertion) - GO:0000175(3'-5'-exoribonuclease activity)|GO:0016891(endoribonuclease activity, producing 5'-phosphomonoesters)|GO:0006396(RNA processing)|GO:0003727(single-stranded RNA binding)|GO:0000178(exosome (RNase complex))|GO:0006401(RNA catabolic process)|GO:0005634(nucleus)|GO:0005730(nucleolus) intenz:3.1.13(identity)|wwpdb:4ifd(identity)|pubmed:23376952(see-also)|pubmed:19129231(see-also)|pubmed:17643380(see-also)|pubmed:10465791(see-also)|pubmed:9562621(see-also)|intenz:3.1.26(identity)|pubmed:26726035(see-also)|pubmed:23910895(see-also)|wwpdb:4oo1(subset)|pubmed:23352926(see-also)|pubmed:17174896(see-also)|complex portal:CPX-599(complex-primary)|wwpdb:2wp8(subset)|pubmed:27345150(see-also) 3-prime to 5-prime exo- and endoribonuclease complex that is involved in RNA maturation and degradation which include the removal of unstable and aberrant transcripts and may also regulate the levels of specific transcripts in response to environmental factors. Restricted to processing linear and circular single-stranded RNAs only. RNAs with complex secondary structures, particularly at the 3-prime end of the molecule, may have to be unwound or pre-processed by co-factors prior to entering the complex. Although some RNAs may be targeted directly to the catalytic subunits, the majority of substrates enter the barrel-like structure of the exosome through a pore at the centre of the cap and are threaded through the central channel in a 3-prime to 5-prime orientation. The ribonuclease activity of the catalytic subunits facilitates the degradation process. Two different exosomes exist in yeast, one found in the nucleus and nucleolus (this complex), the other form is lacking the RRP6 subunit and is found in the cytosol (CPX-603). The nuclear/nucleolar RNA exosome is involved in a) proper maturation of most RNA species such as intron-removal from pre-mRNAs and tRNA precursors and rRNA, snRNA, snoRNA, lncRNA and enhancer RNA processing, especially the removal of their 3-prime ends, b) the elimination of RNA processing by-products and non-coding, cryptic transcripts, such as upstream antisense RNA species (uaRNA), enhancer RNAs (eRNAs), heterochromatin-forming repetitive elements (ribosomal DNA repeats and centromeres) and long non-coding RNAs, c) the elimination of mRNAs with processing defects and mRNAs that fail to undergo proper splicing or 3′ end formation and d) gene expression either by mRNA processing or coordination of intron retention leading to regulation of decay of otherwise intact mRNAs. Nuclear exosome activity therefore limits or excludes export of target RNAs to the cytoplasm. Possibly also involved in the degradation of mRNAs with defects in their co-transcriptional packaging into ribonucleoprotein particles (mRNPs), retention of aberrant transcripts on the chromatin and transcription termination or DNA damage repair processes. The RNA exosome contains a catalytically inactive but evolutionarily conserved core complex of 9 subunits (Exo-9). This barrel-shaped Exo-9 is formed by a hexameric ring of RNase PH domain-containing subunits RRP41-RRP45, RRP46-RRP43 and MTR3-RRP42, and a peripheral cap consisting of S1 domain-containing components CSL4, RRP4 and RRP40 located on the top of the ring structure. Exo-9 has no exoribonuclease activity but facilitates the binding and presentation of RNA for ribonucleolysis and serves as a scaffold for the association with the catalytic subunits. Full ribonuclease activity is only achieved when DIS3 (RRP44) and RRP6 bind to the base of Exo-9 and to its cap-side, respectively. Heteroundecamer manganese(2+) (Mn2+, CHEBI:29035): can replace Mg2+ as cofactor - - - - psi-mi:"MI:0469"(IntAct) P25359(1)|P38792(1)|P46948(1)|P48240(1)|P53256(1)|P53859(1)|Q05636(1)|Q08162(1)|Q08285(1)|Q12149(1)|Q12277(1) +CPX-603 Cytoplasmic exosome complex, DIS3 variant - 559292 CHEBI:18420(2)|P25359(1)|P38792(1)|P46948(1)|P48240(1)|P53256(1)|P53859(1)|Q05636(1)|Q08162(1)|Q08285(1)|Q12277(1) ECO:0005546(biological system reconstruction evidence based on paralogy evidence used in manual assertion) - GO:0000175(3'-5'-exoribonuclease activity)|GO:0016891(endoribonuclease activity, producing 5'-phosphomonoesters)|GO:0006396(RNA processing)|GO:0003723(RNA binding)|GO:0000178(exosome (RNase complex))|GO:0006401(RNA catabolic process)|GO:0005634(nucleus)|GO:0005730(nucleolus) pubmed:23376952(see-also)|pubmed:19129231(see-also)|pubmed:17643380(see-also)|pubmed:10465791(see-also)|pubmed:9562621(see-also)|pubmed:26726035(see-also)|pubmed:23910895(see-also)|wwpdb:4oo1(subset)|pubmed:23352926(see-also)|pubmed:17174896(see-also)|complex portal:CPX-603(complex-primary)|pubmed:27345150(see-also)|complex portal:CPX-599(inferred-from) 3-prime to 5-prime exo- and endoribonuclease complex that is involved in RNA maturation and degradation which include the removal of unstable and aberrant transcripts and may also regulate the levels of specific transcripts in response to environmental factors. Restricted to processing linear and circular single-stranded RNAs only. RNAs with complex secondary structures, particularly at the 3-prime end of the molecule, may have to be unwound or pre-processed by co-factors prior to entering the complex. Although some RNAs may be targeted directly to the catalytic subunit, the majority of substrates enter the barrel-like structure of the exosome through a pore at the centre of the cap and are threaded through the central channel in a 3-prime to 5-prime orientation. The ribonuclease activity of the catalytic subunit facilitates the degradation process. Two different exosomes exist in yeast, one found in the nucleus and nucleolus (CPX-599), the other form is lacking the RRP6 (Q12149) subunit and is found in the cytosol (this complex). The cytoplasmic RNA exosome is involved in general mRNA turnover (esp of Polymerase III transcripts) and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3-prime untranslated regions and cytoplasmic rRNAs that have undergone polyadenylation. Degrades mRNAs subject to RNA interference and is involved in the following mRNA decay pathways: mRNAs with premature termination codons (PTCs; the nonsense mediated decay (NMD) pathway), ones lacking termination codons altogether (the non-stop decay (NSD) pathway) and ones where ribosomes stall (the no-go decay (NGD) pathway). May be involved in degradation of histone mRNA. The RNA exosome contains a catalytically inactive but evolutionarily conserved core complex of 9 subunits (Exo-9). This barrel-shaped Exo-9 is formed by a hexameric ring of RNase PH domain-containing subunits RRP41-RRP45, RRP46-RRP43 and MTR3-RRP42, and a peripheral cap consisting of S1 domain-containing components CSL4, RRP4 and RRP40 located on the top of the ring structure. Exo-9 has no exoribonuclease activity but facilitates the binding and presentation of RNA for ribonucleolysis and serves as a scaffold for the association with the catalytic subunit. Full ribonuclease activity is only achieved when DIS3 (RRP44) binds to the base of Exo-9. Heteroundecamer manganese(2+) (Mn2+, CHEBI:29035): can replace Mg2+ as cofactor - - - - psi-mi:"MI:0469"(IntAct) P25359(1)|P38792(1)|P46948(1)|P48240(1)|P53256(1)|P53859(1)|Q05636(1)|Q08162(1)|Q08285(1)|Q12277(1) +CPX-607 Arp2/3 complex ARP complex|actin-related protein complex.|ARP2-ARP3-ARPC1-ARPC2-ARPC3-ARPC4-ARPC5 complex 559292 P32381(1)|P33204(1)|P38328(1)|P40518(1)|P47117(1)|P53731(1)|Q05933(1) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0005885(Arp2/3 protein complex)|GO:0045010(actin nucleation)|GO:0003779(actin binding)|GO:0034314(Arp2/3 complex-mediated actin nucleation)|GO:0005524(ATP binding)|GO:0015629(actin cytoskeleton) complex portal:CPX-607(complex-primary)|pubmed:16990851(see-also) Highly conserved actin regulator that nucleates branched actin networks associated with regions of the plasma membrane and capable of generating protrusive force and resisting mechanical deformation. Purified Arp2/3 complex is inactive but stimulates rapid actin polymerization in the presence of activator proteins, the most potent type being the VCA domain-containing Wiskott-Aldrich syndrome protein (WASP) family members. The Arp2/3 complex appears to bind VCA and an existing actin filament in a cooperative manner, inducing a major conformational change, which brings Arp2 and Arp3 to an actin dimer-like arrangement and allows recruitment of an actin monomer tethered through the VC region of VCA, leading to formation of a new filament, that emerges from an existing filament in a y-branch configuration with a regular 70degree branch angle. The process appears to be ATP-dependent. - Heteroheptamer - - - - - psi-mi:"MI:0469"(IntAct) P32381(1)|P33204(1)|P38328(1)|P40518(1)|P47117(1)|P53731(1)|Q05933(1) +CPX-609 Signal recognition particle SRP 559292 P20424(1)|P29478(1)|P32342(1)|P38687(1)|P38688(1)|P38985(1)|URS00001CAAE9_559292(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-1251175 GO:0005786(signal recognition particle, endoplasmic reticulum targeting)|GO:0003924(GTPase activity)|GO:0006617(SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition) complex portal:CPX-609(complex-primary)|pubmed:15718142(see-also)|pubmed:1655273(see-also)|pubmed:15837181(see-also) A conserved ribonucleoprotein particle, which includes in its structure a small cytoplasmic RNA (scRNA). In co-translational targeting of membrane and secretory proteins, SRP recognizes signal sequences as soon as they emerge from the ribosomal polypeptide exit tunnel and binds to the ribosome-nascent chain complex (RNC), leading to retardation of peptide elongation. The SRP-RNC complex is targeted to the endoplasmic reticulum (ER) membrane by interaction with the SRP receptor (SR). After docking to the membrane, the RNC is transferred to the protein-conducting channel, the translocon, and protein synthesis continues. The SRP-SR complex dissociates from the ribosome and, as a result of GTP hydrolysis, SRP and SR dissociate from each other. GTP binding to both SRP and SR is required for SRP-SR complex formation. Signal sequence binding and GTP-dependent interaction with SR are mediated by the SRP54 subunit, a multidomain protein with an N-terminal four-helix bundle (N domain), a central GTPase domain (G domain) and a C-terminal methionine-rich domain (M domain). The N-terminal domain (SRP54N) is tightly associated with the G domain (SRP54NG) and may be involved in regulating GTP affinity. The genes encoding scR1 and SRP54p are not essential for growth, although SRP-deficient cells grow poorly, suggesting that an alternative, SRP-independent targeting pathway(s) to the ER membrane exists. SRP is a 16 S particle. At least SRP14, SRP21, SRP68 and SRP72 are proposed to get assembled together with scR1 RNA as a pre-SRP complex in the nucleolus which is exported to the cytoplasm. Heterohexamer - - - - - psi-mi:"MI:0469"(IntAct) P20424(1)|P29478(1)|P32342(1)|P38687(1)|P38688(1)|P38985(1) +CPX-636 ISW1b chromatin remodeling complex ISW1b complex|Imitation switch complex 1b 559292 P38144(1)|Q04213(1)|Q12072(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-1250684 GO:0016587(Isw1 complex)|GO:0006338(chromatin remodeling)|GO:0008094(DNA-dependent ATPase activity)|GO:0005524(ATP binding)|GO:0003677(DNA binding)|GO:0006355(regulation of transcription, DNA-templated)|GO:0009408(response to heat)|GO:0140658(ATPase-dependent chromatin remodeler activity) complex portal:CPX-636(complex-primary)|intenz:3.6.1.-(identity) ATP-dependent chromatin remodeling complex, however ISW1b has a low affinity for nucleosomes resulting in a loss of nucleosome spacing and sliding activities. Appears to play a role in response to increases in temperature and is required for the transcriptional repression of a number of genes, this set differs from those repressed by ISW1a (CPX-637) with which it shares a catalytic subunit. - Heterotrimer - - - - - psi-mi:"MI:0469"(IntAct) P38144(1)|Q04213(1)|Q12072(1) +CPX-637 ISW1a chromatin remodeling complex ISW1a complex|Imitation switch complex 1a|ISW1a chromatin-remodeling complex. 559292 P38144(1)|P43596(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-1250694 GO:0016587(Isw1 complex)|GO:0006338(chromatin remodeling)|GO:0008094(DNA-dependent ATPase activity)|GO:0003677(DNA binding)|GO:0005524(ATP binding)|GO:0006355(regulation of transcription, DNA-templated)|GO:0140658(ATPase-dependent chromatin remodeler activity) complex portal:CPX-637(complex-primary)|pubmed:17283061(see-also)|intenz:3.6.1(identity) ATP-dependent chromatin remodeling complex which modulates the structure of chromatin to regulate a variety of cellular processes, including DNA replication, repair, chromosome segregation and transcription. Slides mononucleosomes from the end to the center of DNA and requires the flexible, acidic patch of the histone H4 tail to efficiently dock its translocase on the nucleosome, for stimulating the ATPase activity and inducing nucleosome mobility. Positions histone octamers in dinucleosomes more specifically than in mononucleosomes. Regularly spaces nucleosomes in vitro every 175 bp. ISW1a bound to 33 bp of extranucleosomal DNA at both entry/exit sites is in an inactive conformation, activated on binding to extranucleosomal DNA at only one entry/exit site. ISW1a bound to only one extranucleosomal DNA makes a stable contact with nucleosomal DNA two helical turns from the dyad axis, and this interaction is lost when ISW1a is bound to extranucleosomal DNA at both entry/exit sites. Required for the transcriptional repression of a number of genes, this set differs from those repressed by ISW1b (CPX-636) with which it shares a catalytic subunit. - Heterodimer - - - - - psi-mi:"MI:0469"(IntAct) P38144(1)|P43596(1) +CPX-656 SAGA complex Spt-Ada-Gcn5 acetyltransferase complex|ADA2-ADA3-CHD1-GCN5-ADA1-SGF11-SGF29-SGF73-ADA5-SPT3-SPT7-SPT8-SUS1-TAF10-TAF12-TAF5-TAF6-TAF9-TRA1-UBP8 complex|Something about silencing complex 559292 P06844(0)|P25554(0)|P32494(0)|P32657(0)|P35177(0)|P38129(0)|P38811(0)|P38915(0)|P50102(0)|P50875(0)|P53040(0)|P53165(0)|Q02336(0)|Q03067(0)|Q03330(0)|Q03761(0)|Q05027(0)|Q12030(0)|Q12060(0)|Q6WNK7(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0006357(regulation of transcription from RNA polymerase II promoter)|GO:0000124(SAGA complex)|GO:0004402(histone acetyltransferase activity)|GO:0016573(histone acetylation)|GO:0016578(histone deubiquitination)|GO:0004843(thiol-dependent ubiquitinyl hydrolase activity)|GO:0031492(nucleosomal DNA binding)|GO:0031493(nucleosomal histone binding) intenz:3.4.19.12(identity)|wwpdb:3M99(subset)|wwpdb:3MHH(subset)|wwpdb:4FIP(subset)|wwpdb:4fjc(subset)|wwpdb:4wa6(subset)|complex portal:CPX-656(complex-primary)|rhea:RHEA:45948(identity)|wwpdb:3kik(subset)|wwpdb:3kjl(subset)|pubmed:10422263(see-also)|pubmed:15260971(see-also)|pubmed:12186975(see-also)|intenz:2.3.1.48(identity)|pubmed:15647753(see-also)|pubmed:14718168(see-also)|pubmed:15506919(see-also)|pubmed:20434206(see-also)|pubmed:25216679(see-also) A transcriptional co-activator complex with histone acetyltransferase activity. Recruited to gene loci by the interaction of TRA1 with specific transcriptional activators, and the bromodomain of GCN5 binds acetylated H3 and H4 N-terminal tails which potentiates cooperative nucleosome acetylation of histone H3 catalysed by the acetylation module. This opens up the chromatin landscape for binding of additional transcription factors and the pre-initiation complex. The DUB module facilitates elongation through deubiquitination of H2B which allows for the recruitment of the CTK1 kinase (Q03957) and subsequent Ser-2 phosophorylation of the Pol II C-terminal domain. Organized into several functional submodules: a histone acetyltransferase (HAT) module consisting of GCN5, ADA2, NGG1/ADA3 and SGF29, a histone deubiquitinase (DUB) module consisting of UBP8, SGF11, SGF73 and SUS1, a core architecture module consisting of HFI1, SPT7, SPT20, TAF5, TAF6, TAF9, TAF10 and TAF12, a TBP-interaction module consisting of SPT3 and SPT8, substrate recognition subunit CHD1 and transcription factor-binding subunit TRA1. Closely related to SAGA-like SLIK complex (CPX-675) but contains additional subunits SPT8, SGF11, SGF73 and SUS1 and lacks RTG2 (P32608). MW = 1.8 MDa. - - - - - - psi-mi:"MI:0469"(IntAct) P06844(0)|P25554(0)|P32494(0)|P32657(0)|P35177(0)|P38129(0)|P38811(0)|P38915(0)|P50102(0)|P50875(0)|P53040(0)|P53165(0)|Q02336(0)|Q03067(0)|Q03330(0)|Q03761(0)|Q05027(0)|Q12030(0)|Q12060(0)|Q6WNK7(0) +CPX-684 Mating-type MATalpha2-MATa1 complex - 559292 P0CY08(1)|P0CY11(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-12501451 GO:0008301(DNA binding, bending)|GO:0001227(transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding)|GO:0090571(RNA polymerase II transcription repressor complex)|GO:1990837(sequence-specific double-stranded DNA binding)|GO:0001198(negative regulation of mating-type specific transcription from RNA polymerase II promoter) wwpdb:1AKH(identity)|wwpdb:1YRN(identity)|wwpdb:1le8(identity)|complex portal:CPX-684(complex-primary) Transcriptional repressor with a role in determining the three cell types of Saccharomyces cerevisiae: the a and alpha haploid cells and the a/alpha diploid cell type. Binds to a 21-base pair DNA sequence, the haploid-specific gene (hsg) operator, to repress transcription of haploid-specific genes and of MATALPHA1 (P0CY06). Both MATA1 and MATALPHA2 contain C-terminal homeodomains each of which comprises of three alpha-helices connected by short peptides. The third homeodomain makes specific contacts with nucleotides in the major groove of the DNA duplex, thus determining DNA binding specificity. The MATA1 and MATALPHA2 homeodomains bind in a head-to-tail orientation, with heterodimer contacts mediated by a 16-residue tail located carboxyl-terminal to the MATALPHA2 homeodomain. This tail becomes ordered in the presence of MATA1, part of it forming a short amphipathic helix that packs against the MATA1 homeodomain between helices 1 and 2. A pronounced 60 degree bend is induced in the DNA. Heterodimer - - - - The reference sequence for yeast is from strain S288c, which is a MAT alpha haploid. This means it does not have an active MATA1 protein. The sequence found in UniProtKB for A1 is from other (MAT a) strains, therefore stored under the mnemonic YEASX, and not YEAST. psi-mi:"MI:0469"(IntAct) P0CY08(1)|P0CY11(1) +CPX-692 Mating-type MATalpha2-MCM1 complex - 559292 P0CY08(2)|P11746(2) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-12514986 GO:0001198(negative regulation of mating-type specific transcription from RNA polymerase II promoter)|GO:0008301(DNA binding, bending)|GO:0001227(transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding)|GO:0090571(RNA polymerase II transcription repressor complex)|GO:1990837(sequence-specific double-stranded DNA binding) wwpdb:1MNM(identity)|complex portal:CPX-692(complex-primary) Transcriptional repressor with a role in determining the three cell types of Saccharomyces cerevisiae: the a and alpha haploid cells and the a/alpha diploid cell type. Binds to a 30- or 31-base-pair (bp) a-specific operator DNA, which contains the pseudosymmetric MCM1 16-bp P-box-binding site flanked on either side by alpha2-binding sites, to repress transcription of a-specific genes. alpha2 uses a short eight-amino-acid module in the linker region to bind MCM1 via parallel beta-strands. This recognition strand is tethered to the alpha2 homeodomain by a segment of unusual conformational flexibility. Additional contacts are also made between the MATalpha2 homeodomain and MCM1. Heterotetramer - - - - - psi-mi:"MI:0469"(IntAct) P0CY08(2)|P11746(2) +CPX-693 Mating-type MATalpha1-MCM1 complex - 559292 P0CY06(2)|P11746(2) ECO:0005546(biological system reconstruction evidence based on paralogy evidence used in manual assertion) - GO:0001197(positive regulation of mating-type specific transcription from RNA polymerase II promoter)|GO:0008301(DNA binding, bending)|GO:0001228(transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding)|GO:0090575(RNA polymerase II transcription factor complex)|GO:1990837(sequence-specific double-stranded DNA binding) complex portal:CPX-692(inferred-from)|complex portal:CPX-693(complex-primary) Transcriptional activator with a role in determining the three cell types of Saccharomyces cerevisiae: the a and alpha haploid cells and the a/alpha diploid cell type. Binds P-primeQ promoter elements to activate the expression of alpha-specific genes. - Heterotetramer - - - - - psi-mi:"MI:0469"(IntAct) P0CY06(2)|P11746(2) +CPX-695 Adenylyl cyclase complex Suppressor of ras:cyclase associated protein complex 559292 P08678(0)|P17555(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-12520447 GO:0004016(adenylate cyclase activity)|GO:0046579(Ras protein signal transduction)|GO:0005524(ATP binding) intenz:4.6.1.1(identity)|pubmed:9774417(see-also)|pubmed:9032232(see-also)|pubmed:8391632(see-also)|complex portal:CPX-695(complex-primary)|pubmed:10594005(see-also)|pubmed:11919151(see-also) An adenylate cyclase complex probably required for an enhanced response of adenylyl cyclase to activated RAS family members. Adenylyl cyclase catalyzes the synthesis of a second messenger, cAMP. Formation of this complex may create a second RAS binding site, required for activation of CYR1 by RAS family members. - - - - - - psi-mi:"MI:0469"(IntAct) P08678(0)|P17555(0) +CPX-728 ISW2 chromatin remodeling complex ISW2 chromatin-remodeling complex variant 1|ISW2 complex|Imitation switch complex 2|CHRAC-like complex|Isw2p-Itc1p complex|Imitation switch two complex|CHRAC complex|Chromatin accessibility complex 559292 P40366(0)|P53125(0)|Q04603(0)|Q08773(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-1251892 GO:0140658(ATPase-dependent chromatin remodeler activity)|GO:0008623(CHRAC)|GO:0031492(nucleosomal DNA binding)|GO:0008094(DNA-dependent ATPase activity)|GO:0006338(chromatin remodeling)|GO:0005524(ATP binding)|GO:0006355(regulation of transcription, DNA-templated) complex portal:CPX-728(complex-primary)|intenz:3.6.1(identity)|pubmed:17491017(see-also) ATP-dependent chromatin remodeling complex which is required for repression of early meiotic genes during mitotic cell growth. Slides mononucleosomes from the end to the center of DNA and requires the flexible, acidic patch of the histone H4 tail to efficiently dock its translocase on the nucleosome, for stimulating the ATPase activity and inducing nucleosome mobility. Preferentially bind nucleosome substrates containing ~70 bp extranucleosomal DNA at one entry/exit site of the nucleosome. ISW2 interacts with three nucleosomal and extranucleosomal regions. Itc1 and Isw2 bind to the region 2 helical turns from the dyad axis and a region closest to the entry/exit site. Itc1 subunit makes extensive contacts with extranucleosomal DNA. The DPB4 subunit contacts extranucleosomal DNA 37-53 bp away from the entry/exit site of the nucleosome and probably serves as an anchor point for ISW2 on DNA. The DPB4/DLS1 dimer acts to affect the nucleosome spacing activity of the complex, the ability to sense an adjacent nucleosome and to regulate remodeling and may affect the target gene profile it regulates. - - - - - - - psi-mi:"MI:0469"(IntAct) P40366(0)|P53125(0)|Q04603(0)|Q08773(0) +CPX-729 Box C/D snoRNP complex - 559292 CHEBI:133335(0)|CHEBI:67040(0)|P15646(0)|P39990(0)|Q12460(0)|Q12499(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-10955136 GO:0031428(box C/D snoRNP complex)|GO:0000494(box C/D snoRNA 3'-end processing)|GO:0008171(O-methyltransferase activity)|GO:0000452(snoRNA guided rRNA 2'-O-methylation) intenz:2.1.1(identity)|complex portal:CPX-729(complex-primary)|pubmed:12007400(see-also) Small nucleolar ribonucleoprotein particles (snoRNP) with a role in pre-rRNA cleavage and in 2-prime-O-methylation of nucleotides at specific positions in rRNAs, snoRNAs, and other RNAs during maturation. The snoRNA present in the complex guides the site-specific 2-prime-O-ribose methylation by base pairing with the rRNA for 10 to 21 nucleotides immediately 5-prime of box D. The residue targeted for methylation in the substrate RNA invariably pairs with the fifth nucleotide upstream of box D in the guide snoRNA. The complex also acts to direct pre-rRNA folding and rRNA processing through base pairing to the rRNA or flanking precursor sequences. The RNA component of the complex functions in substrate binding by base pairing with the target site and also as a scaffold coordinating the organization of the complex. The box C/D core motif of the RNA moiety directs the binding of NOP1, NOP56, NOP58, and SNU13 snoRNP proteins. The SNU13 protein interacts directly with the box C/D motif which forms a kink-turn (K-turn) secondary structure motif. - - - - - - psi-mi:"MI:0469"(IntAct) P15646(0)|P39990(0)|Q12460(0)|Q12499(0) +CPX-734 ISW2 chromatin remodeling complex variant 2 ISW2 chromatin-remodeling complex|ISW2 complex|Imitation switch complex 2|CHRAC-like complex|Isw2p-Itc1p complex|Imitation switch two complex|CHRAC complex 559292 P53125(0)|Q08773(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-787286 GO:0140658(ATPase-dependent chromatin remodeler activity)|GO:0008623(CHRAC)|GO:0031492(nucleosomal DNA binding)|GO:0008094(DNA-dependent ATPase activity)|GO:0006338(chromatin remodeling)|GO:0005524(ATP binding)|GO:0006355(regulation of transcription, DNA-templated) complex portal:CPX-734(complex-primary)|intenz:3.6.1(identity)|pubmed:17491017(see-also) ATP-dependent chromatin remodeling complex which is required for repression of early meiotic genes during mitotic cell growth. Slides mononucleosomes from the end to the center of DNA and requires the flexible, acidic patch of the histone H4 tail to efficiently dock its translocase on the nucleosome, for stimulating the ATPase activity and inducing nucleosome mobility. Preferentially bind nucleosome substrates containing ~70 bp extranucleosomal DNA at one entry/exit site of the nucleosome. ISW2 interacts with three nucleosomal and extranucleosomal regions. ITC1 and ISW2 bind to the region 2 helical turns from the dyad axis and a region closest to the entry/exit site. ITC1 subunit makes extensive contacts with extranucleosomal DNA. The absence of the histone fold dimer DPB4/DLS1 present in variant 1 (CPX-728) appears to alter the target gene profile regulated by this complex, the dimer acts to affect its nucleosome spacing activity, the ability to sense an adjacent nucleosome and to regulate remodeling. - - - - - - - psi-mi:"MI:0469"(IntAct) P53125(0)|Q08773(0) +CPX-737 Box H/ACA ribonucleoprotein complex - 559292 CHEBI:133336(0)|P28007(1)|P32495(0)|P33322(1)|Q6Q547(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-12521293 GO:0031429(box H/ACA snoRNP complex)|GO:0000454(snoRNA guided rRNA pseudouridine synthesis)|GO:0009982(pseudouridine synthase activity) intenz:5.4.99(identity)|complex portal:CPX-737(complex-primary)|wwpdb:3u28(subset) Pseudouridine synthesis complex that converts uridine into pseudouridine at numerous specific sites within ribosomal RNAs (rRNAs) and spliceosomal small nuclear RNAs (snRNAs), isomerizing the uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine residues may serve to stabilize the conformation of rRNAs. Eukaryotic H/ACA RNAs contain a 5-prime hairpin followed by a single-stranded H box (ANANNA, where N is any nucleotide), and a 3-prime hairpin followed by a related ACA box. Each functional hairpin contains a large internal loop, called the pseudouridylation pocket, which is able to form a bipartite RNA duplex around the target uridine in substrates, hence determining the modification specificity. - - - - - - psi-mi:"MI:0469"(IntAct) P28007(1)|P32495(0)|P33322(1)|Q6Q547(1) +CPX-756 Anaphase-Promoting core complex Anaphase-Promoting Complex|Anaphase Promoting Complex/Cyclosome|APC/C|APC|Cyclosome|Anaphase-Promoting Complex core complex 559292 P09798(0)|P14724(0)|P16522(0)|P38042(0)|P40577(0)|P53068(0)|P53886(0)|Q04601(0)|Q08683(0)|Q12107(0)|Q12157(0)|Q12379(0)|Q12440(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-1251419 GO:0005680(anaphase-promoting complex)|GO:0031145(anaphase-promoting complex-dependent catabolic process)|GO:0016567(protein ubiquitination)|GO:0007346(regulation of mitotic cell cycle)|GO:0061630(ubiquitin protein ligase activity) complex portal:CPX-756(complex-primary)|pubmed:29167309(see-also)|emdb:EMD-1820(identity)|emdb:EMD-1821(identity)|emdb:EMD-1822(identity)|intenz:6.3.2.19(identity)|pubmed:9695848(see-also)|pubmed:15678131(see-also)|pubmed:16896351(see-also)|pubmed:16364911(see-also)|pubmed:15797379(see-also) APC, a key regulator of cell cycle progression, is a conserved cullin-RING E3 ubiqutin ligase which facilitates multiubiqutination of cell cycle proteins, including cyclins, so marking them for proteasomal destruction. Generally believed that APC acts as a scaffold that brings E2 enzymes and substrates into close proximity. APC activity is required for metaphase-anaphase transition, mitotic exit, G1 phase and DNA replication. Targets securin for destruction, which is necessary for chromosome segregation. APC seems to have similar function in meiosis. Co-activators, CDC20 and CDH1, associate with APC core complex at specific stages of cell cycle, and are thought to be involved in substrate specificity. APC-Cdc20 (CPX-760) is active in presence of high cyclin-cdk activity in M phase but after metaphase when cyclin-cdk activity decreases, Cdh1 is dephosphorylated, CDC20 is degraded and APC-CDH1 (CPX-761) activated. Ama1 (CPX-762) is meiotic co-activator required for sporulation and contributes to securin degradation and cyclin Clb5 in anaphase of meiosis. All APC co-activators, characterized by the presence of sequence elements, C-box and the IR-tail, that mediate their binding to APC, contain a C-terminal WD40 domain, predicted to fold into a propeller-like structure, believed to recognize APC substrates by interacting with specific recognition elements in substrates, D-boxes and KEN-boxes. Genetic inactivation of APC is lethal. MW = 1.7 MDa. APC is an asymmetric triangular complex (200 by 230 A in size), composed of an outer wall that encloses an internal cavity. The largest APC subunit, APC1, bridges two distinct subcomplexes, the “catalytic core” subcomplex including APC2 and APC11, the Cullin and RING-finger subunits that characterize the APC as a member of the multisubunit cullin-RING family of ubiquitin ligases, and the three TPR subunits CDC27, CDC16, and CDC23, and requires APC4 and APC5 to interact with Apc1. May also exist as a dimer in vivo. Purified APC forms dimers in vitro, which have enhanced processivity. - - - - - - psi-mi:"MI:0469"(IntAct) P09798(0)|P14724(0)|P16522(0)|P38042(0)|P40577(0)|P53068(0)|P53886(0)|Q04601(0)|Q08683(0)|Q12107(0)|Q12157(0)|Q12379(0)|Q12440(0) +CPX-760 Anaphase-Promoting Complex, CDC20 variant Anaphase-Promoting Complex|Anaphase Promoting Complex/Cyclosome|APC/C|APC|Cyclosome|APC-Cdc20 559292 P09798(0)|P14724(0)|P16522(0)|P26309(0)|P38042(0)|P40577(0)|P53068(0)|P53886(0)|Q04601(0)|Q08683(0)|Q12107(0)|Q12157(0)|Q12379(0)|Q12440(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0007346(regulation of mitotic cell cycle)|GO:0005680(anaphase-promoting complex)|GO:0016567(protein ubiquitination)|GO:0031145(anaphase-promoting complex-dependent catabolic process)|GO:0061630(ubiquitin protein ligase activity) complex portal:CPX-760(complex-primary)|pubmed:15797379(see-also)|intenz:6.3.2.19(identity)|pubmed:9695848(see-also)|pubmed:15678131(see-also)|pubmed:16896351(see-also)|pubmed:16364911(see-also) APC, a key regulator of cell cycle progression, is a conserved cullin-RING E3 ubiqutin ligase which facilitates multiubiqutination of cell cycle proteins, including cyclins, so marking them for proteasomal destruction. Generally believed that APC acts as a scaffold that brings E2 enzymes and substrates into close proximity. APC activity is required for metaphase-anaphase transition, mitotic exit, G1 phase and DNA replication. Targets securin for destruction, which is necessary for chromosome segregation. APC seems to have similar function in meiosis. Co-activators, CDC20 and CDH1, associate with APC core complex (CPX-756) at specific stages of cell cycle, and are thought to be involved in substrate specificity. APC-Cdc20 is active in presence of high cyclin-cdk activity in M phase but after metaphase when cyclin-cdk activity decreases, CDH1 is dephosphorylated, CDC20 is degraded and APC-Cdh1 (CPX-761) activated. Ama1 (CPX-762) is meiotic co-activator required for sporulation and contributes to securin degradation and cyclin Clb5 in anaphase of meiosis. All APC co-activators, characterized by the presence of sequence elements, C-box and the IR-tail, that mediate their binding to APC, contain a C-terminal WD40 domain, predicted to fold into a propeller-like structure, believed to recognize APC substrates by interacting with specific recognition elements in substrates, D-boxes and KEN-boxes. Genetic inactivation of APC is lethal. MW = 1.7 MDa. APC is an asymmetric triangular complex (200 by 230 A in size), composed of an outer wall that encloses an internal cavity. The largest APC subunit, APC1, bridges two distinct subcomplexes, the “catalytic core” subcomplex including APC2 and APC11, the Cullin and RING-finger subunits that characterize the APC as a member of the multisubunit cullin-RING family of ubiquitin ligases, and the three TPR subunits CDC27, CDC16, and CDC23, and requires APC4 and APC5 to interact with Apc1. May also exist as a dimer in vivo. Purified APC forms dimers in vitro, which have enhanced processivity. - - - - - - psi-mi:"MI:0469"(IntAct) P09798(0)|P14724(0)|P16522(0)|P26309(0)|P38042(0)|P40577(0)|P53068(0)|P53886(0)|Q04601(0)|Q08683(0)|Q12107(0)|Q12157(0)|Q12379(0)|Q12440(0) +CPX-761 Anaphase-Promoting Complex, CDH1 variant Anaphase-Promoting Complex|Anaphase Promoting Complex/Cyclosome|APC/C|APC|Cyclosome|APC-Cdh1 559292 P09798(0)|P14724(0)|P16522(0)|P38042(0)|P40577(0)|P53068(0)|P53197(0)|P53886(0)|Q04601(0)|Q08683(0)|Q12107(0)|Q12157(0)|Q12379(0)|Q12440(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0016567(protein ubiquitination)|GO:0005680(anaphase-promoting complex)|GO:0007346(regulation of mitotic cell cycle)|GO:0031145(anaphase-promoting complex-dependent catabolic process)|GO:0061630(ubiquitin protein ligase activity)|GO:0004842(ubiquitin-protein transferase activity) complex portal:CPX-761(complex-primary)|pubmed:15797379(see-also)|intenz:6.3.2.19(identity)|pubmed:9695848(see-also)|pubmed:15678131(see-also)|pubmed:16896351(see-also)|pubmed:16364911(see-also) APC, a key regulator of cell cycle progression, is a conserved cullin-RING E3 ubiqutin ligase which facilitates multiubiqutination of cell cycle proteins, including cyclins, so marking them for proteasomal destruction. Generally believed that APC acts as a scaffold that brings E2 enzymes and substrates into close proximity. APC activity is required for metaphase-anaphase transition, mitotic exit, G1 phase and DNA replication. Targets securin for destruction, which is necessary for chromosome segregation. APC seems to have similar function in meiosis. Co-activators, CDC20 and CDH1, associate with APC core complex (CPX-756) at specific stages of cell cycle, and are thought to be involved in substrate specificity. APC-Cdc20 (CPX-760) is active in presence of high cyclin-cdk activity in M phase but after metaphase when cyclin-cdk activity decreases, Cdh1 is dephosphorylated, Cdc20 is degraded and APC-Cdh1 activated. Ama1 (CPX-762) is meiotic co-activator required for sporulation and contributes to securin degradation and cyclin Clb5 in anaphase of meiosis. All APC co-activators, characterized by the presence of sequence elements, C-box and the IR-tail, that mediate their binding to APC, contain a C-terminal WD40 domain, predicted to fold into a propeller-like structure, believed to recognize APC substrates by interacting with specific recognition elements in substrates, D-boxes and KEN-boxes. Genetic inactivation of APC is lethal. MW = 1.7 MDa. APC is an asymmetric triangular complex (200 by 230 A in size), composed of an outer wall that encloses an internal cavity. The largest APC subunit, APC1, bridges two distinct subcomplexes, the “catalytic core” subcomplex including APC2 and APC11, the Cullin and RING-finger subunits that characterize the APC as a member of the multisubunit cullin-RING family of ubiquitin ligases, and the three TPR subunits CDC27, CDC16, and CDC23, and requires APC4 and APC5 to interact with APC1. May also exist as a dimer in vivo. Purified APC forms dimers in vitro, which have enhanced processivity. - - - - - - psi-mi:"MI:0469"(IntAct) P09798(0)|P14724(0)|P16522(0)|P38042(0)|P40577(0)|P53068(0)|P53197(0)|P53886(0)|Q04601(0)|Q08683(0)|Q12107(0)|Q12157(0)|Q12379(0)|Q12440(0) +CPX-762 Anaphase-Promoting complex AMA1 variant Anaphase-Promoting Complex|Anaphase Promoting Complex/Cyclosome|APC/C|APC|Cyclosome|APC-Ama1 559292 P09798(0)|P14724(0)|P16522(0)|P38042(0)|P40577(0)|P50082(0)|P53068(0)|P53886(0)|Q04601(0)|Q08683(0)|Q12107(0)|Q12157(0)|Q12379(0)|Q12440(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0061630(ubiquitin protein ligase activity)|GO:0031145(anaphase-promoting complex-dependent catabolic process)|GO:0016567(protein ubiquitination)|GO:0051445(regulation of meiotic cell cycle)|GO:0005680(anaphase-promoting complex) complex portal:CPX-762(complex-primary)|pubmed:15797379(see-also)|intenz:6.3.2.19(identity)|pubmed:9695848(see-also)|pubmed:15678131(see-also)|pubmed:16896351(see-also)|pubmed:16364911(see-also) APC, a key regulator of cell cycle progression, is a conserved cullin-RING E3 ubiqutin ligase which facilitates multiubiqutination of cell cycle proteins, including cyclins, so marking them for proteasomal destruction. Generally believed that APC acts as a scaffold that brings E2 enzymes and substrates into close proximity. APC activity is required for metaphase-anaphase transition, mitotic exit, G1 phase and DNA replication. Targets securin for destruction, which is necessary for chromosome segregation. APC seems to have similar function in meiosis.. AMA1 is a meiotic co-activator required for sporulation and contributes to securin degradation and cyclin Clb5 in anaphase of meiosis. AMA1 activates APC/C-mediated degradation during multiple periods in meiosis, including late in the first meiotic division. All APC co-activators, characterized by the presence of sequence elements, C-box and the IR-tail, that mediate their binding to APC, contain a C-terminal WD40 domain, predicted to fold into a propeller-like structure, believed to recognize APC substrates by interacting with specific recognition elements in substrates, D-boxes and KEN-boxes. Genetic inactivation of APC is lethal. MW = 1.7 MDa. APC is an asymmetric triangular complex (200 by 230 A in size), composed of an outer wall that encloses an internal cavity. The largest APC subunit, APC1, bridges two distinct subcomplexes, the “catalytic core” subcomplex including APC2 and APC11, the Cullin and RING-finger subunits that characterize the APC as a member of the multisubunit cullin-RING family of ubiquitin ligases, and the three TPR subunits CDC27, CDC16, and CDC23, and requires APC4 and APC5 to interact with APC1. May also exist as a dimer in vivo. Purified APC forms dimers in vitro, which have enhanced processivity. - - - - - - psi-mi:"MI:0469"(IntAct) P09798(0)|P14724(0)|P16522(0)|P38042(0)|P40577(0)|P50082(0)|P53068(0)|P53886(0)|Q04601(0)|Q08683(0)|Q12107(0)|Q12157(0)|Q12379(0)|Q12440(0) +CPX-768 Nuclear origin recognition complex ORC1-6 complex 559292 P32833(0)|P38826(0)|P50874(0)|P54784(0)|P54790(0)|P54791(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0006270(DNA replication initiation)|GO:0005664(nuclear origin of replication recognition complex)|GO:0005634(nucleus)|GO:0003688(DNA replication origin binding)|GO:0016887(ATPase activity)|GO:0005524(ATP binding) complex portal:CPX-768(complex-primary) Protein complex that binds to origin DNA in an ATP-dependent manner and recruits other essential proteins, such as the initiation factors CDC6 (P09119), Cdt1 (P47112), and the presumptive DNA helicase complex MCM (CPX-2944), to the autonomously replicating sequence (ARS) to form a pre-replicative complex before the initiation of DNA replication that occurs in S phase. - - - - - - - psi-mi:"MI:0469"(IntAct) P32833(0)|P38826(0)|P50874(0)|P54784(0)|P54790(0)|P54791(0) +CPX-769 Protein kinase CK2 variant 2 CK2|CK-2|CKII|casein kinase 2|casein kinase II|CSK21-CSK2B-CSK2C complex 559292 P15790(2)|P38930(1)|P43639(1) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0004674(protein serine/threonine kinase activity)|GO:0005524(ATP binding)|GO:0006468(protein phosphorylation)|GO:0005956(protein kinase CK2 complex)|GO:0051726(regulation of cell cycle)|GO:0005525(GTP binding) pubmed:16265593(see-also)|complex portal:CPX-769(complex-primary)|pubmed:7592778(see-also)|pubmed:12396231(see-also)|intenz:2.7.11.1(identity) CK2 is involved in regulation of cell cycle progression, presumably through phosphorylation of target proteins. CK2 may also have role(s) in inhibiting apoptosis.Phosphorylates serine or threonine residues proximal to acidic amino acids (consensus Ser-Xaa-Xaa-Acidic where acidic residue may be Glu, Asp, pSer or pTYr). Thought to be a dual-specificity kinase in yeast, also able to phosphorylate tyrosine residues, although with less favourable kinetic parameters. ATP or GTP can serve as a phosphate donor. Disruption of CKA1 or CKA2 is not lethal, but disruption of both is synthetic lethal. CKA1 and CKA2 functional overlap is not complete, as yeast with temperature sensitive alleles of CKA1 or CKA2 display distinct phenotypes and different combinations of CKA subunits affect substrate specificity and sub-cellular localization. Disruption of CKB1 or CKB2 causes sensitivity to NaCl and LiCl. Disruption of both CKB1 and CKB2 is not synthetic lethal, although the regulatory subunits are responsible for the structural integrity of the holoenzyme. Much of CK2B is phosphorylated on autophosphorylation site and also in a cell cycle-dependent manner. Km for ATP=4.5uM, KM for GTP=50uM. MW = 155,000–160,000 Da CK2 isoenzymes composed of catalytic alpha and/or alpha-prime subunits with homodimers of regulatory beta2 or beta-prime2 subunits are apparently not formed. Heterotetramer - - - - - psi-mi:"MI:0469"(IntAct) P15790(2)|P38930(1)|P43639(1) +CPX-770 Protein kinase CK2 variant 3 CK2|CK-2|CKII|casein kinase 2|casein kinase II|CSK22-CSK2B-CSK2C complex 559292 P19454(2)|P38930(1)|P43639(1) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0006468(protein phosphorylation)|GO:0051726(regulation of cell cycle)|GO:0004674(protein serine/threonine kinase activity)|GO:0005524(ATP binding)|GO:0005525(GTP binding)|GO:0005956(protein kinase CK2 complex) complex portal:CPX-770(complex-primary)|pubmed:16607517(see-also)|pubmed:12396231(see-also)|intenz:2.7.11.1(identity) CK2 is involved in regulation of cell cycle progression, presumably through phosphorylation of target proteins. CK2 may also have role(s) in inhibiting apoptosis.Phosphorylates serine or threonine residues proximal to acidic amino acids (consensus Ser-Xaa-Xaa-Acidic where acidic residue may be Glu, Asp, pSer or pTYr). Thought to be a dual-specificity kinase in yeast, also able to phosphorylate tyrosine residues, although with less favourable kinetic parameters. ATP or GTP can serve as a phosphate donor. Disruption of CKA1 or CKA2 is not lethal, but disruption of both is synthetic lethal. CKA1 and CKA2 functional overlap is not complete, as yeast with temperature sensitive alleles of CKA1 or CKA2 display distinct phenotypes and different combinations of CKA subunits affect substrate specificity and sub-cellular localization. Disruption of CKB1 or CKB2 causes sensitivity to NaCl and LiCl. Disruption of both CKB1 and CKB2 is not synthetic lethal, although the regulatory subunits are responsible for the structural integrity of the holoenzyme. Much of CK2B is phosphorylated on autophosphorylation site and also in a cell cycle-dependent manner. Km for ATP=8.5uM, KM for GTP=70uM. MW = 140,000–145,000 Da CK2 isoenzymes composed of catalytic alpha and/or alpha-prime subunits with homodimers of regulatory beta2 or beta-prime2 subunits are apparently not formed. Heterotetramer - - - - - psi-mi:"MI:0469"(IntAct) P19454(2)|P38930(1)|P43639(1) +CPX-771 UTP-C complex variant 2 - 559292 P15790(2)|P25368(0)|P38930(1)|P43639(1)|P53254(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0000028(ribosomal small subunit assembly)|GO:0004674(protein serine/threonine kinase activity)|GO:0034456(UTP-C complex) wwpdb:4m5d(subset)|complex portal:CPX-771(complex-primary)|pubmed:17515605(see-also)|intenz:2.7.11.1(identity) A subcomplex of the 90S preribosome required for early processing of 18S rRNA and 40S ribosome formation. A sub-unit of the small subunit (SSU) processome, a 2.2 MDa ribonucleoprotein complex involved in the processing, assembly and maturation of the SSU ribosome. - - - - - - psi-mi:"MI:0469"(IntAct) P15790(2)|P25368(0)|P38930(1)|P43639(1)|P53254(0) +CPX-772 UTP-C complex variant 1 - 559292 P15790(1)|P19454(1)|P25368(0)|P38930(1)|P43639(1)|P53254(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0034456(UTP-C complex)|GO:0004674(protein serine/threonine kinase activity)|GO:0000028(ribosomal small subunit assembly) complex portal:CPX-772(complex-primary)|wwpdb:4m5d(subset)|pubmed:17515605(see-also)|intenz:2.7.11.1(identity) A subcomplex of the 90S preribosome required for early processing of 18S rRNA and 40S ribosome formation. A sub-unit of the small subunit (SSU) processome, a 2.2 MDa ribonucleoprotein complex involved in the processing, assembly and maturation of the SSU ribosome. - - - - - - psi-mi:"MI:0469"(IntAct) P15790(1)|P19454(1)|P25368(0)|P38930(1)|P43639(1)|P53254(0) +CPX-773 UTP-C complex variant 3 - 559292 P19454(2)|P25368(0)|P38930(1)|P43639(1)|P53254(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0000028(ribosomal small subunit assembly)|GO:0004674(protein serine/threonine kinase activity)|GO:0034456(UTP-C complex) wwpdb:4m5d(subset)|complex portal:CPX-773(complex-primary)|pubmed:17515605(see-also)|intenz:2.7.11.1(identity) A subcomplex of the 90S preribosome required for early processing of 18S rRNA and 40S ribosome formation. A sub-unit of the small subunit (SSU) processome, a 2.2 MDa ribonucleoprotein complex involved in the processing, assembly and maturation of the SSU ribosome. Heterotetramer - - - - - psi-mi:"MI:0469"(IntAct) P19454(2)|P25368(0)|P38930(1)|P43639(1)|P53254(0) +CPX-774 CURI complex variant 1 CK2-Utp22-Rrp7-Ifh1 complex variant 1 559292 P15790(1)|P19454(1)|P25368(0)|P38930(1)|P39520(0)|P43639(1)|P53254(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0042790(transcription of nuclear large rRNA transcript from RNA polymerase I promoter)|GO:0005524(ATP binding)|GO:0005525(GTP binding)|GO:0006468(protein phosphorylation)|GO:0032545(CURI complex)|GO:0004674(protein serine/threonine kinase activity)|GO:0060962(regulation of ribosomal protein gene transcription from RNA polymerase II promoter) complex portal:CPX-774(complex-primary)|wwpdb:4M5D(subset)|pubmed:27818142(see-also)|pubmed:27863222(see-also)|pubmed:17452446(see-also)|intenz:2.7.11.1(identity) Plays a role in coupling ribosomal protein gene transcription and ribosomal RNA synthesis and processing. Acts to sequester the ribosomal protein (RP)-specific transcription factor, IFH1, to reduce transcription of RP genes during periods of growth inhibition. Upon growth inhibition, the key regulator of cell growth, TORC1 is inactivated, which leads to rapid release of IFH1 from the RP gene promoter. RNA polymerase I activity inhibits the ability of UTP22, a component of both this complex and the SSU processome, to titrate IFH1 from RPG promoters. The CURI complex also activate transcription of RP genes since the CK2 component of the CURI complex can phosphorylate IFH1 at the sites essential for strong binding to FHL1 at the RP promoters. - Heterotetramer - - - - - psi-mi:"MI:0469"(IntAct) P15790(1)|P19454(1)|P25368(0)|P38930(1)|P39520(0)|P43639(1)|P53254(0) +CPX-775 CURI complex variant 2 CK2-Utp22-Rrp7-Ifh1 complex variant 2 559292 P15790(2)|P25368(0)|P38930(1)|P39520(0)|P43639(1)|P53254(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0004674(protein serine/threonine kinase activity)|GO:0005524(ATP binding)|GO:0005525(GTP binding)|GO:0006468(protein phosphorylation)|GO:0032545(CURI complex)|GO:0042790(transcription of nuclear large rRNA transcript from RNA polymerase I promoter)|GO:0060962(regulation of ribosomal protein gene transcription from RNA polymerase II promoter) complex portal:CPX-775(complex-primary)|wwpdb:4M5D(subset)|pubmed:27818142(see-also)|pubmed:27863222(see-also)|pubmed:17452446(see-also)|intenz:2.7.11.1(identity) Plays a role in coupling ribosomal protein gene transcription and ribosomal RNA synthesis and processing. Acts to sequester the ribosomal protein (RP)-specific transcription factor, IFH1, to reduce transcription of RP genes during periods of growth inhibition. Upon growth inhibition, the key regulator of cell growth, TORC1 is inactivated, which leads to rapid release of IFH1 from the RP gene promoter. RNA polymerase I activity inhibits the ability of UTP22, a component of both this complex and the SSU processome, to titrate IFH1 from RPG promoters. The CURI complex also activate transcription of RP genes since the CK2 component of the CURI complex can phosphorylate IFH1 at the sites essential for strong binding to FHL1 at the RP promoters. - - - - - - - psi-mi:"MI:0469"(IntAct) P15790(2)|P25368(0)|P38930(1)|P39520(0)|P43639(1)|P53254(0) +CPX-776 CURI complex variant 3 CK2-Utp22-Rrp7-Ifh1 complex variant 3 559292 P19454(2)|P25368(0)|P38930(1)|P39520(0)|P43639(0)|P53254(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0004674(protein serine/threonine kinase activity)|GO:0005524(ATP binding)|GO:0005525(GTP binding)|GO:0006468(protein phosphorylation)|GO:0032545(CURI complex)|GO:0042790(transcription of nuclear large rRNA transcript from RNA polymerase I promoter)|GO:0060962(regulation of ribosomal protein gene transcription from RNA polymerase II promoter) wwpdb:4M5D(subset)|complex portal:CPX-776(complex-primary)|pubmed:27818142(see-also)|pubmed:27863222(see-also)|pubmed:17452446(see-also)|intenz:2.7.11.1(identity) Plays a role in coupling ribosomal protein gene transcription and ribosomal RNA synthesis and processing. Acts to sequester the ribosomal protein (RP)-specific transcription factor, IFH1, to reduce transcription of RP genes during periods of growth inhibition. Upon growth inhibition, the key regulator of cell growth, TORC1 is inactivated, which leads to rapid release of IFH1 from the RP gene promoter. RNA polymerase I activity inhibits the ability of UTP22, a component of both this complex and the SSU processome, to titrate IFH1 from RPG promoters. The CURI complex also activate transcription of RP genes since the CK2 component of the CURI complex can phosphorylate IFH1 at the sites essential for strong binding to FHL1 at the RP promoters. - - - - - - - psi-mi:"MI:0469"(IntAct) P19454(2)|P25368(0)|P38930(1)|P39520(0)|P43639(0)|P53254(0) +CPX-777 SAS acetyltransferase complex Something About Silencing complex|SAS complex|SAS-I complex. 559292 P40963(1)|Q04003(1)|Q99314(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-1252427 GO:0033255(SAS acetyltransferase complex)|GO:0004402(histone acetyltransferase activity)|GO:0016573(histone acetylation)|GO:0031935(regulation of chromatin silencing) complex portal:CPX-777(complex-primary)|intenz:2.3.1.48(identity)|pubmed:15659401(see-also)|pubmed:15788653(see-also) Histone acetyltransferase (HAT) complex capable of acetylating both free histones and nucleosomes, although the nucleosomal HAT activity of SAS complex is relatively weak. Exclusively acetylates Lys-16 of histone H4 and may provide a barrier to Sir (silent information regulator) proteins that would prevent adjacent euchromatic regions from being transcriptionally inactivated. The complex appears to assemble in the nucleus, following the separate import of the components. MW=125kDa Heterotrimer - - - - - psi-mi:"MI:0469"(IntAct) P40963(1)|Q04003(1)|Q99314(1) +CPX-778 TRM11-TRM112 tRNA (m2G10) methyltransferase complex Trm11/Trm112 2'-O-ribose methyltransferase complex|tRNA guanosine-2'-O-methyltransferase complex|Trm11p-Trm112p complex|S-adenosyl-L-methionine-dependent methyltransferase complex|SAM-dependent methyltransferase complex|S-adenosylmethionine-dependent methyltransferase complex 559292 P53738(1)|Q12463(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-1253449 GO:0043528(tRNA (m2G10) methyltransferase complex)|GO:0004809(tRNA (guanine-N2-)-methyltransferase activity)|GO:0030488(tRNA methylation) complex portal:CPX-778(complex-primary)|intenz:2.1.1(identity)|pubmed:28134793(see-also) S-adenosylmethionine-dependent methyltransferase responsible for the formation of N2-monomethylguanosine at position 10 (m2G10) in yeast cytoplasmic tRNA. The m2G10 is part of the body of the tRNA and is likely involved in tRNA folding and stability. m2G10 is stacked onto the m22G26 nucleotide which is methylated by Trm1 (P15565). - Heterodimer - - - - - psi-mi:"MI:0469"(IntAct) P53738(1)|Q12463(1) +CPX-779 Elongator holoenzyme complex elongator complex|RNA polymerase II elongator complex 559292 P38874(2)|P42935(2)|Q02884(2)|Q02908(2)|Q04868(2)|Q06706(2) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-1254570 GO:0008080(N-acetyltransferase activity)|GO:0000049(tRNA binding)|GO:0033588(Elongator holoenzyme complex)|GO:0006417(regulation of translation)|GO:0002098(tRNA wobble uridine modification) wwpdb:4a8j(subset)|complex portal:CPX-779(complex-primary)|intenz:2.3.1(identity)|pubmed:17320508(see-also)|pubmed:27974378(see-also)|pubmed:18332122(see-also) N-acetyltransferase which acts to form modified wobble uridines in tRNA, such as 5-methoxycarbonylmethyl-uridine (mcm5U), 5-methoxycarbonylmethyl-2-thio-uridine (mcm5s2U), and 5-carbamoylmethyl-uridine (ncm5U). These sites influence the recognition rate and affinity between incoming tRNAs and codons in the A site of the translating ribosome, stablizing transient pausing events thus supporting proper domain folding of the nascent polypeptide chains during the elongation phase of the ribosome‐mediated translation process. Composed of two weakly associated subcomplexes - ELP1-ELP2-ELP3 and ELP4-ELP5-ELP6. Two copies of the ELP1, ELP2, and ELP3 subunits form a two-lobed scaffold, which binds the ELP456 heterohexameric, ring-like structure asymmetrically. Heterododecamer - - - - - psi-mi:"MI:0469"(IntAct) P38874(2)|P42935(2)|Q02884(2)|Q02908(2)|Q04868(2)|Q06706(2) +CPX-780 Signal recognition particle receptor complex signal recognition particle receptor complex|SR complex|SR|SRPR|SRP receptor|docking protein complex|docking protein 559292 CHEBI:15996(1)|P32916(1)|P36057(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-1035919 GO:0006617(SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition)|GO:0005047(signal recognition particle binding)|GO:0005785(signal recognition particle receptor complex)|GO:0003924(GTPase activity)|GO:0016021(integral component of membrane) complex portal:CPX-780(complex-primary)|pubmed:15837181(see-also)|wwpdb:1NRJ(identity)|pubmed:15718142(see-also) Mediates the co-translational targeting of membrane and secretory proteins. The signal recognition particle (SRP) binds to 9-12 large hydrophobic residues that constitute the signal sequences of nascent proteins as they emerge from the exit tunnel of the ribosome. The resulting targeting complex, composed of the SRP and the ribosome-nascent chain complex, then docks with the Signal recognition particle receptor. This interaction catalyzes the GTP-dependent transfer of the nascent chain from SRP to the protein translocation apparatus in the ER membrane. Following GTP hydrolysis, the complex dissociates. Transmembrane complex, both subunits of which contain GTPase domains. The dimerization of the eukaryotic SRP receptor may be regulated by the GTP/GDP switch cycle of SRP102. - - - - - - psi-mi:"MI:0469"(IntAct) P32916(1)|P36057(1) +CPX-781 NatC N-alpha-acetyltransferase complex N-terminal acetyltransferase C complex|NatC Nalpha-terminal acetyltransferase|N(alpha)-acetyltransferase NatC|L-A virus GAG protein N-acetyltransferase 559292 P23059(0)|Q02197(0)|Q03503(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-808326 GO:0006474(N-terminal protein amino acid acetylation)|GO:0031417(NatC complex)|GO:0004596(peptide alpha-N-acetyltransferase activity) complex portal:CPX-781(complex-primary)|intenz:2.3.1.88(identity)|pubmed:12890471(see-also)|pubmed:11274203(see-also) N(alpha)-acetyltransferases, NatA (CPX-781), NatB (CPX-782) and NatC, carry out N-terminal acetylation, one of the most common co-translational modifications. Mak3 is the catalytic subunit of NatC. All three subunits are required for NatC activity. NatC substrates are rare but subclasses of proteins with Met-Ile, Met-Leu, Met-Trp, or Met-Phe termini are not acetylated in Mak3 deletion mutants. All three deletion strains showed similar phenotypes, including slower growth on non-fermentable carbon sources at elevated temperature. - - - - - - - psi-mi:"MI:0469"(IntAct) P23059(0)|Q02197(0)|Q03503(0) +CPX-782 NatB N-alpha-acetyltransferase complex N-terminal acetyltransferase B complex|NatB Nalpha-terminal acetyltransferase|N(alpha)-acetyltransferase NatB 559292 Q06504(0)|Q12387(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0031416(NatB complex)|GO:0006474(N-terminal protein amino acid acetylation)|GO:0004596(peptide alpha-N-acetyltransferase activity) complex portal:CPX-782(complex-primary)|rhea:RHEA:50484(identity)|rhea:RHEA:50492(identity)|rhea:RHEA:50480(identity)|rhea:RHEA:50488(identity)|intenz:2.3.1.254(identity)|pubmed:12890471(see-also) N(alpha)-acetyltransferases, NatA (CPX-783), NatB and NatC (CPX-781), carry out N-terminal acetylation, the covalent attachment of an acetyl group (CH3CO) to the free alpha-amino group (NH3+) at the N-terminal end of a polypeptide, one of the most common co-translational modifications. This changes the electrostatic properties of proteins and therefore protein function, stability and localization. NatB is responsible for the acetylation of methionine-acidic/hydrophilic N-termini (Met-Asp-, Met-Asn-, Met-Glu-, and Met-Gln-). NAT3 is the catalytic subunit, MDM20 anchors to the ribosome and interacts with nascent polypeptides. - - - - - - psi-mi:"MI:0469"(IntAct) Q06504(0)|Q12387(0) +CPX-783 NatA N-alpha-acetyltransferase complex N-terminal acetyltransferase A complex|NatA Nalpha-terminal acetyltransferase|N(alpha)-acetyltransferase NatA 559292 P07347(0)|P12945(0)|Q08689(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-2291009 GO:0031415(NatA complex)|GO:0006474(N-terminal protein amino acid acetylation)|GO:0004596(peptide alpha-N-acetyltransferase activity) complex portal:CPX-783(complex-primary)|intenz:2.3.1.255(identity)|pubmed:12890471(see-also)|pubmed:11274203(see-also)|pubmed:18615858(see-also) N(alpha)-acetyltransferases, NatA, NatB (CPX-783) and NatC (CPX-781), carry out N-terminal acetylation, one of the most common co-translational modifications. NatA is the major Nalpha-terminal acetyltransferase in the yeast cytosol, responsible for the acetylation of serine, alanine, threonine, and glycine. NAT1 anchors to the ribosome and interacts with nascent polypeptides. - - - - - - - psi-mi:"MI:0469"(IntAct) P07347(0)|P12945(0)|Q08689(0) +CPX-784 Vacuolar transporter chaperone complex - 559292 P40046(0)|P43585(0)|P47075(0)|Q02725(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-1255052 GO:0007034(vacuolar transport)|GO:0005516(calmodulin binding)|GO:0033254(vacuolar transporter chaperone complex)|GO:0016237(lysosomal microautophagy)|GO:0061736(engulfment of target by autophagosome)|GO:0000421(autophagosome membrane)|GO:0016021(integral component of membrane) complex portal:CPX-784(complex-primary)|pubmed:17079729(see-also) High-molecular-weight integral membrane complex enriched at the vacuolar membrane, but also localizes to other cellular compartments. Vtc proteins have been implicated in several membrane-related processes, such as sorting of H+-translocating ATPases, endocytosis, ER-Golgi trafficking, vacuole fusion, vacuolar polyphosphate homeostasis and the microautophagic scission of vesicles into the vacuolar lumen. May bind calmodulin during some, or all, of these processes. Vtc1, Vtc2 and Vtc3 are integral membrane proteins with three predicted transmembrane helices at their C-termini. The N-terminal regions of Vtc2 and Vtc3 form large hydrophilic domains exposed to the cytosol and are homologous to Vtc4, which has no predicted transmembrane spans but behaves like an integral membrane protein. - - - - - - psi-mi:"MI:0469"(IntAct) P40046(0)|P43585(0)|P47075(0)|Q02725(0) +CPX-813 Palmitoyltransferase ERF2/SHR5 complex Erf2/Erf4 PAT complex|Palmitoyltransferase ERF2-SHR5 complex|Erf2-Erf4 PAT complex 559292 P41912(0)|Q06551(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-12556304 GO:0018230(peptidyl-L-cysteine S-palmitoylation)|GO:0031211(endoplasmic reticulum palmitoyltransferase complex)|GO:0030176(integral component of endoplasmic reticulum membrane)|GO:0019706(protein-cysteine S-palmitoyltransferase activity) intenz:2.3.1.225(identity)|complex portal:CPX-813(complex-primary)|pubmed:20851885(see-also)|pubmed:10490616(see-also)|pubmed:12193598(see-also) Palmitoyltransferase complex that catalyzes the palmitoylation of proteins through a two step reaction - the autopalmitoylation of the enzyme to create a palmitoyl-ERF2 intermediate followed by the transfer of the palmitoyl moiety to the RAS substrate. Palmitoyl-CoA serves as the palmitate donor. ERF2 appears to have a direct role in palmitate transfer based on its ability to form an acyl-intermediate. - - - - - - psi-mi:"MI:0469"(IntAct) P41912(0)|Q06551(0) +CPX-828 RTG transcription factor complex RTG1-RTG3 transcription factor complex|RTG complex 559292 P32607(1)|P38165(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-1149611 GO:0005667(transcription factor complex)|GO:0005634(nucleus)|GO:0001046(core promoter sequence-specific DNA binding)|GO:0006357(regulation of transcription, DNA-templated)|GO:0031930(mitochondria-nucleus signaling pathway)|GO:0016559(peroxisome fission) complex portal:CPX-828(complex-primary)|pubmed:9032238(see-also) Heterodimeric transcription factor involved in the regulation of nuclear genes, such as CIT2, in response to mitochondrial stress. Also essential for peroxisome proliferation. Binds to each of two identical non-E-box core sequences, 5-GGTCAC-3, in the 76-bp regulatory upstream activation sequence element of the CIT2 promoter. - Homodimer - - - - - psi-mi:"MI:0469"(IntAct) P32607(1)|P38165(1) +CPX-863 INO80 chromatin remodeling complex INO80 chromatin remodeling complex|Ino80 ATPase 559292 P32617(1)|P35189(1)|P40060(1)|P40154(1)|P43579(1)|P53115(1)|P53946(1)|P60010(1)|P80428(1)|Q03435(1)|Q03940(6)|Q08561(1)|Q12345(1)|Q12386(1)|Q12464(6) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-515508 GO:0140658(ATPase-dependent chromatin remodeler activity)|GO:0006338(chromatin remodeling)|GO:0031011(Ino80 complex)|GO:0031491(nucleosome binding)|GO:0016887(ATPase activity)|GO:0006281(DNA repair)|GO:0006355(regulation of transcription, DNA-templated)|GO:0005524(ATP binding)|GO:0005634(nucleus) complex portal:CPX-863(complex-primary)|intenz:3.6.4.12(identity)|pubmed:17316710(see-also)|pubmed:17320816(see-also) Chromatin remodeling complex with both DNA-dependent ATPase activity, as well as 3'-5' helicase activity. Mobilizes mononucleosomes in an ATP-dependent manner thus regulating a distinct subset of genes. Also involved in multiple DNA repair pathways by its nucleosome remodeling ability, by regulating the accessibility of DNA repair proteins around the DNA double strand break site and by facilitating efficient homologous recombination. MW = 1000 - 1500 kDa. An asymmetric, embryo-shaped structure that consists of a globular head that is connected to a body and foot via a neck. The overall dimensions are 310 × 210 × 160A. The globular head has a diameter of approximately 120 A and is formed by the Rvb1/2 heterododecamer. It is positioned laterally on one end of the cone-shaped neck-body-foot structure, creating a sharp kink in INO80 with a prominent groove. Hetero 25-mer - - - - - psi-mi:"MI:0469"(IntAct) P32617(1)|P35189(1)|P40060(1)|P40154(1)|P43579(1)|P53115(1)|P53946(1)|P60010(1)|P80428(1)|Q03435(1)|Q03940(6)|Q08561(1)|Q12345(1)|Q12386(1)|Q12464(6) +CPX-867 DBF4-dependent CDC7 kinase complex DDK complex|Dbf4-dependent protein kinase complex 559292 P06243(0)|P32325(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-2112988 GO:1905561(positive regulation of kinetochore assembly)|GO:0060903(positive regulation of meiosis I)|GO:0005813(centrosome)|GO:0031431(Dbf4-dependent protein kinase complex)|GO:0004674(protein serine/threonine kinase activity)|GO:0006468(protein phosphorylation)|GO:0005524(ATP binding)|GO:0005634(nucleus)|GO:1903343(positive regulation of meiotic DNA double-strand break formation)|GO:0006270(DNA replication initiation) intenz:2.7.11.1(identity)|pubmed:28025497(see-also)|complex portal:CPX-867(complex-primary) Serine/threonine-protein kinase essential for the initiation of DNA replication and commitment of meiotic cells to reductional chromosome segregation in meiosis I. Associates with replication origins where it phosphorylates components of the prereplicative complex including the MCM helicase (CPX-2944). Has post-replicative functions in meiosis and is essential for double-strand break formation and kinetochore localization of monopolin. - - - - - - - psi-mi:"MI:0469"(IntAct) P06243(0)|P32325(0) +CPX-868 FET3-FTR1 high affinity iron permease complex FTR1/FES3 permease oxidase complex 559292 CHEBI:23378(4)|P38993(1)|P40088(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-926334 GO:0015092(high-affinity ferric iron uptake transmembrane transporter activity)|GO:0033573(high-affinity iron permease complex)|GO:0098706(ferric iron import across cell outer membrane)|GO:0004322(ferroxidase activity)|GO:0008198(ferrous iron binding)|GO:0008199(ferric iron binding)|GO:0005887(integral component of plasma membrane) pubmed:9413439(see-also)|intenz:1.-.-.-(identity)|pubmed:10608875(see-also)|pubmed:16522632(see-also)|complex portal:CPX-868(complex-primary)|pubmed:16700543(see-also) High affinity iron uptake complex present in the plasma membrane. The complex forms in the endoplasmic reticulum and then traffics to the plasma membrane. Environmental ferric iron (Fe(III), Fe3+) is mobilized by reduction to ferrous ion (Fe(II), Fe2+) by surface metalloreductases such as FRE1 (P32791), followed by oxidation to Fe(III) by FET3. This FET3-bound Fe(III) is the substrate for permeation facilitated by FTR1. FET3 and FTR1 interact through specific sequence motifs localized in both the exocellular and cytoplasmic domains. The cytoplasmic motifs are required for the trafficking of the two proteins to the plasma membrane. - Fe(II) (CHEBI:29033)|Fe(III) (CHEBI:29034) - - - - psi-mi:"MI:0469"(IntAct) P38993(1)|P40088(0) +CPX-869 FET5-FTH1 high affinity iron exporter complex - 559292 CHEBI:23378(4)|P38310(0)|P43561(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-995090 GO:0061841(high-affinity iron exporter complex)|GO:0071627(integral component of fungal-type vacuolar membrane)|GO:0004322(ferroxidase activity)|GO:0008198(ferrous iron binding)|GO:0055072(iron ion homeostasis)|GO:0061840(high-affinity ferrous iron uptake transmembrane transporter activity)|GO:0034755(iron ion transmembrane transport) pubmed:9413439(see-also)|intenz:1.-.-.-(identity)|pubmed:10608875(see-also)|complex portal:CPX-869(complex-primary) High-affinity vacuolar exporter complex which transports ferrous iron ions (Fe(II), Fe2+) from the vacuole, the main storage component of intracellular free iron, into the cytoplasm in a low iron environment. The complex forms in the endoplasmic reticulum and then traffics to the vacuolar membrane. Plays a role in the switch from fermentative metabolism to respiratory metabolism. The C-termini of both subunits are orientated towards the cytosol. - Fe(III) (CHEBI:29034) - - - - psi-mi:"MI:0469"(IntAct) P38310(0)|P43561(1) +CPX-940 ESCRT-I complex ESCRT-I complex|ESCRT1 complex|Endosomal sorting complex required for transport-I complex.|ESCRT-1 complex 559292 P25604(1)|P42939(1)|Q02767(1)|Q99176(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-1267663 GO:0000813(ESCRT I complex)|GO:0043130(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|GO:0043162(ubiquitin binding) complex portal:CPX-940(complex-primary)|wwpdb:2f66(subset)|wwpdb:2caz(subset)|wwpdb:2p22(identity)|pubmed:17135292(see-also)|pubmed:17145965(see-also)|pubmed:17442384(see-also) The ESCRT machinery consists of ESCRT-0 (CPX-1622), -I (this complex), -II (CPX-1623), -III (CPX-1624) and -IV (VPS4 complex, CPX-334) and is required for the downregulation of cell-surface receptors and for the final membrane scission step during endocytosis. The ESCRT-I complex directs the lysosomal degradation of ubiquinated transmembrane proteins. Consists of a headpiece attached to a stalk, the latter being important for the stability and assembly of the complex, and may act as a spacer regulating the disposition of the cargo. Is recruited to the multivesicular body (MVB) vesicles by ESCRT-0 which localizes to the endosome by binding to the lipid phosphatidylinositol 3-phosphate. On the endosomal membrane both ESCRT-I and ESCRT-0 bind to ubiquitinated endosomal cargo. A docked model places the stalk parallel to the plane of the membrane, but not in direct contact with it, spatially organizing interactions of membrane-bound structures by imposing physical restrictions on their distances relative to each other. MW = 350kDa. The core complex is 18nM long, the stalk being 13nM. Heterotetramer - - - - - psi-mi:"MI:0469"(IntAct) P25604(1)|P42939(1)|Q02767(1)|Q99176(1) +CPX-946 SBF transcription complex SBF transcription factor complex|SCB binding factor|SWI4/SWI6 complex|SWI4/6 complex|Swi4/6 cell cycle box binding factor. 559292 P09959(1)|P25302(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-1267998 GO:0000082(G1/S transition of mitotic cell cycle)|GO:0006355(regulation of transcription, DNA-templated)|GO:0005634(nucleus)|GO:0033309(SBF transcription complex)|GO:0003700(DNA-binding transcription factor activity) complex portal:CPX-946(complex-primary)|pubmed:11206552(see-also)|pubmed:7917338(see-also) Heteromeric transcription factor, composed of a regulatory subunit SWI6) and a DNA-binding protein (SWI4), that activates gene expression during the G1/S transition of the cell cycle. Binds to a sequence motif called the SCB element (Swi4/6 cell cycle box, CACGAAA) which acts as a late Gl-specific UAS element in genes predominantly involved in budding, and in membrane and cell-wall biosynthesis. MW = 180 kDa Heterodimer - - - - - psi-mi:"MI:0469"(IntAct) P09959(1)|P25302(1) +CPX-950 MBP transcription complex MBF transcription factor complex|MCB binding factor|Mlu1 cell cycle box binding factor. 559292 P09959(0)|P39678(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-1268092 GO:0030907(MBF transcription complex)|GO:0006355(regulation of transcription, DNA-templated)|GO:0000082(G1/S transition of mitotic cell cycle)|GO:0003700(DNA-binding transcription factor activity) complex portal:CPX-950(complex-primary)|pubmed:7917338(see-also) Heteromeric transcription factor, composed of a regulatory subunit (Swi6) and a DNA-binding protein (Mbp1), that activates gene expression during the G1/S transition of the cell cycle. Binds to a sequence motif called the MCB element (MluI cell cycle box, ACGCGTNA) which acts as a late Gl-specific UAS element in genes predominantly involved in DNA replication and repair . - - - - - - - psi-mi:"MI:0469"(IntAct) P09959(0)|P39678(0) +CPX-956 GET complex Golgi to ER Traffic complex|GET insertase complex 559292 CHEBI:29105(1)|P40056(2)|P53192(2)|Q12154(2) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-15941383 GO:0043529(GET complex)|GO:0045048(protein insertion into ER membrane)|GO:0005524(ATP binding)|GO:0016887(ATPase activity)|GO:0032977(membrane insertase activity)|GO:0030176(integral component of endoplasmic reticulum membrane) wwpdb:3SJD(subset)|wwpdb:3ZS9(subset)|complex portal:CPX-956(complex-primary)|intenz:3.6(identity)|pubmed:21866104(see-also)|emdb:EMD-11607(identity)|pubmed:32910895(see-also)|pubmed:16269340(see-also) Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. GET1 and GET2 act as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol, delivered to it by the GET4-GET5 transmembrane domain recognition complex (CPX-1861). Cooperates with the HDEL receptor ERD2 (P18414) to mediate the ATP-dependent retrieval of resident endoplasmic reticulum proteins that contain a C-terminal HDEL retention signal from the Golgi to the endoplasmic reticulum. In the cytoplasm, the TA protein interacts with the closed ADP-bound form of the GET3 dimer, which encloses the substrate transmembrane domain within a hydrophobic groove. GET3 then first binds to the flexible cytoplasmic domain of GET from a pair of GET1/GET2 heterodimers, and subsequently to the GET1-cytoplasmic domains which drives the formation of a GET1/GET2 membrane heterotetramer stabilized by phosphatidylinositol binding at the heterotetramer interface. Binding to GET1 stabilizes the open form of the GET3 dimer, leading to nucleotide release and disruption of the substrate binding site. A short GET2 cytoplasmic alpha helix guides the substrate transmembrane domain towards the bilayer, interactions between the substrate C-terminus and the hydrophilic groove of GET1 then enables insertion into the membrane. - - - - - - psi-mi:"MI:0469"(IntAct) P40056(2)|P53192(2)|Q12154(2) +CPX-961 Mitotic spindle assembly checkpoint, MAD1-MAD2 complex Mad1-Mad2 core complex 559292 P40957(0)|P40958(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-1268845 GO:0033316(meiotic spindle assembly checkpoint)|GO:0000776(kinetochore)|GO:0051312(chromosome decondensation)|GO:0007094(mitotic spindle assembly checkpoint)|GO:0051315(attachment of mitotic spindle microtubules to kinetochore) complex portal:CPX-961(complex-primary)|pubmed:15951820(see-also)|pubmed:17038540(see-also) Acts at the spindle checkpoint, in a surveillance mechanism that mediates a delay in the onset of anaphase, until all chromosomes are properly attached to the mitotic or meiotic spindle. Required for the checkpoint response to absence of spindle tension, localising only to unattached kinetochores but not to attached kinetochores that lack tension, and participate in a bipolar orientation defect signaling pathway. MAD2 adopts two distinct conformations; when unbound, it adopts an open conformation (O-Mad2) but upon binding to MAD1 (or CDC20, P26309), two beta-sheets move across the face of the protein to create the closed conformation (C-Mad2), with MAD1 now trapped within this fold. Upon mitotic entry, the Mad1-C-Mad2 core complex is recruited to kinetochores. Because Mad2 can dimerise, O-Mad2 from the cytosol can then be recruited to kinetochore-bound Mad1-C-Mad2. C-Mad2 within the Mad1-C-Mad2 core complex acts as a prion-like template, catalysing the conversion of additional O-Mad2 proteins to the closed conformation and in doing so binding Cdc20 (CPX-962). MW = greater than 670 kDa. - - - - - - psi-mi:"MI:0469"(IntAct) P40957(0)|P40958(0) +CPX-962 Mitotic checkpoint complex, CDC20-MAD2 subcomplex Mad2-Cdc20 complex 559292 P26309(0)|P40958(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-1269099 GO:1990333(mitotic checkpoint complex, CDC20-MAD2 subcomplex)|GO:0051444(negative regulation of ubiquitin-protein transferase activity)|GO:0007094(mitotic spindle assembly checkpoint) complex portal:CPX-962(complex-primary)|pubmed:16636141(see-also)|pubmed:17038540(see-also) Acts at the spindle checkpoint, in a surveillance mechanism that mediates a metaphase delay, until all chromosomes are properly attached to the mitotic or meiotic spindle, by sequestering Cdc20, thus preventing the activation of the the ubiquitin ligase activity of the anaphase-promoting complex (CPX-760). This ensures all chromosomes are correctly attached in a bipolar fashion to the mitotic spindle. Mad2 adopts a closed conformation (C-Mad2 ) when bound to Cdc20, and an open conformation (O-Mad2) when unbound. Checkpoint activation promotes the conversion of open conformation to Cdc20-bound closed conformation Mad2. - - - - - - psi-mi:"MI:0469"(IntAct) P26309(0)|P40958(0) +CPX-963 Mitotic checkpoint complex, MAD2-MAD3-BUB3-CDC20 MCC complex 559292 P26309(0)|P26449(0)|P40958(0)|P47074(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-1271142 GO:0033597(mitotic checkpoint complex)|GO:0010997(anaphase-promoting complex binding)|GO:0007094(mitotic spindle assembly checkpoint)|GO:0051444(negative regulation of ubiquitin-protein transferase activity)|GO:0004857(enzyme inhibitor activity) complex portal:CPX-963(complex-primary)|pubmed:28920074(see-also)|pubmed:15879521(see-also)|pubmed:17038540(see-also) Acts at the spindle checkpoint in a surveillance mechanism that mediates a delay in the onset of anaphase until all chromosomes are properly attached to the mitotic or meiotic spindle by inhibiting the anaphase-promoting complex (CPX-760), an E3 ubquitin ligase complex required for onset of anaphase. The Mitotic checkpoint complex is a more potent inhibitor of the APC/C than Mad2-Cdc20 alone (CPX-962). - - - - - - - psi-mi:"MI:0469"(IntAct) P26309(0)|P26449(0)|P40958(0)|P47074(0) +CPX-964 GTPase-Activating Protein BFA1-BUB2 complex - 559292 P26448(0)|P47113(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-1271244 GO:0005096(GTPase activator activity)|GO:1990334(Bfa1-Bub2 complex)|GO:0031578(mitotic spindle orientation checkpoint)|GO:0043547(positive regulation of GTPase activity) complex portal:CPX-964(complex-primary)|pubmed:12048186(see-also) Acts as a two-component GTPase-activating protein for TEM1 (P38987) GTPase, thus regulating a signal transduction cascade, called the mitotic exit network (MEN), which is required for mitotic exit and cytokinesis. The BUB2/BFA1 GAP binds TEM1 GTPase at spindle poles, achieving an asymmetry during mitosis when the spindle is properly positioned, with the complex accumulating on the bud-directed old spindle pole. BUB2/BFA1 keeps TEM1 inactive until the spindle is properly oriented, thus inhibiting MEN activation. Upon spindle misalignment TEM1 localizes symmetrically on both SPBs and the Spindle Position Checkpoint (SPOC) inhibits TEM1 through the BUB2/BFA1 complex, thereby restraining the MEN until the spindle repositions correctly. - - - - - - - psi-mi:"MI:0469"(IntAct) P26448(0)|P47113(0) +CPX-977 CDC24-FAR1-Gbetagamma complex CDC24-FAR1-BG complex 559292 P11433(0)|P18851(0)|P18852(0)|P21268(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-6964064 GO:0010969(regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion)|GO:0005938(cell cortex)|GO:0120171(Cdc24p-Far1p-Gbetagamma complex) complex portal:CPX-977(complex-primary) Required for oriented growth of haploid cells in response to a pheromone gradient created by a mating partner of the opposite mating type. Forms at the cell cortex during mating, when a Far1-Cdc24 complex translocates from the nucleus. Recruits Cdc42 (P19073) and Bem1 (P29366) away from the bud site, thus providing the switch from bud growth to polarized growth, enabling the cell to project a shmoo towards the source of a pheromone gradient, and thus grow towards the mating partner. Binding to Gbetagamma may trigger a conformational change in Far1 that is required for its ability to activate Cdc24. - - - - - - - psi-mi:"MI:0469"(IntAct) P11433(0)|P18851(0)|P18852(0)|P21268(0) +CPX-995 KEOPS complex N(6)-L-threonylcarbamoyladenine synthase complex|Kinase, putative Endopeptidase, and Other Proteins of Small size complex|EKC complex|Endopeptidase-like Kinase Chromatin-associated complex 559292 CHEBI:60240(1)|P36132(1)|P46984(1)|P53323(1)|Q03705(1)|Q3E833(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-1201092 GO:0002949(tRNA threonylcarbamoyladenosine modification)|GO:0000723(telomere maintenance)|GO:0061711(N(6)-L-threonylcarbamoyladenine synthase)|GO:0000408(EKC/KEOPS complex)|GO:1990145(maintenance of translational fidelity)|GO:0005524(ATP binding) wwpdb:4WX8(subset)|wwpdb:4wxa(subset)|wwpdb:4ww7(subset)|wwpdb:4ww9(subset)|wwpdb:4wwa(subset)|intenz:2.3.1.234(identity)|pubmed:16564010(see-also)|pubmed:25735745(see-also)|wwpdb:4ww5(subset)|complex portal:CPX-995(complex-primary)|pubmed:16874308(see-also)|pubmed:21183954(see-also) Catalyses the transfer of the threonylcarbamoyl-moiety of threonylcarbamoyladenylate (TCA) onto A37 of substrate tRNA in the cytoplasm. The N6-threonylcarbamoyladenosine (t6A) modification is present at position 37 of tRNAs that recognize ANN-codons, with N being any nucleotide, enhancing the codon-anti-codon interaction and is required for recognition of the AUG start codon. The modification is thus important for maintaining translational fidelity and also appears to play a role in transcription and telomere homeostasis. The unstable TCA intermediate is synthesised from ATP, threonine and bicarbonate by the SUA5 (P32579) enzyme. The complex forms a linear heteropentameric structure. The active site of KAE1, centered on the conserved metal cluster and containing an ATP binding site, is at the bottom of a crater whose walls are made of KAE1, BUD32, PCC1 and GON7. Residues from KAE1, BUD32 and PCC1 contribute to a positively-charged surface patch around the ATP binding site of KAE1, which may be involved in tRNA binding. Binding to KAE1 appears to maintain BUD32 in an inactive conformation inhibiting its kinase activity. Heteropentamer - - - - - psi-mi:"MI:0469"(IntAct) P36132(1)|P46984(1)|P53323(1)|Q03705(1)|Q3E833(1) +CPX-999 MET4-MET28-MET31 sulfur metabolism transcription factor complex - 559292 P32389(0)|P40573(0)|Q03081(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0000981(RNA polymerase II transcription factor activity, sequence-specific DNA binding)|GO:0045944(positive regulation of transcription from RNA polymerase II promoter)|GO:0042762(regulation of sulfur metabolic process)|GO:0005667(transcription factor complex) complex portal:CPX-999(complex-primary) Transcription factor complex regulating sulfur metabolism. MET4 lacks DNA-binding ability and relies on interactions with MET31 and MET32 (Q03081), paralogous proteins that bind the same cis-regulatory element, to activate its targets. MET31 and MET32 are C2H2 zinc finger-containing proteins that act solely as adaptors for recruiting MET4 to promoters, binding to sites with a TGTGGC core. MET28 acts to stabilise the complex. - - - - - - - psi-mi:"MI:0469"(IntAct) P32389(0)|P40573(0)|Q03081(0) +CPX-1015 MET4-MET28-MET32 sulfur metabolism transcription factor complex - 559292 P32389(0)|P40573(0)|Q12041(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0005667(transcription factor complex)|GO:0000981(RNA polymerase II transcription factor activity, sequence-specific DNA binding)|GO:0045944(positive regulation of transcription from RNA polymerase II promoter)|GO:0042762(regulation of sulfur metabolic process) complex portal:CPX-1015(complex-primary) Transcription factor complex regulating sulfur metabolism. MET4 lacks DNA-binding ability and relies on interactions with MET31 (Q03081) and MET32, paralogous proteins that bind the same cis-regulatory element, to activate its targets. MET31 and MET32 are C2H2 zinc finger-containing proteins that act solely as adaptors for recruiting MET4 to promoters, binding to sites with a TGTGGC core. MET28 acts to stabilise the complex. - - - - - - - psi-mi:"MI:0469"(IntAct) P32389(0)|P40573(0)|Q12041(0) +CPX-1016 CBF1-MET4-MET28 sulfur metabolism transcription factor complex - 559292 P17106(2)|P32389(0)|P40573(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0000981(RNA polymerase II transcription factor activity, sequence-specific DNA binding)|GO:0045944(positive regulation of transcription from RNA polymerase II promoter)|GO:0042762(regulation of sulfur metabolic process)|GO:0089713(Cbf1-Met4-Met28 complex) complex portal:CPX-1016(complex-primary) Transcription factor complex regulating sulfur metabolism. MET4 lacks DNA-binding ability and relies on its interaction with CBF1 to activate its targets. CBF1 is a basic helix–loop–helix factor protein that that homodimerizes to bind a cis-regulatory element CACGTGA motif and then recruits the transactivator MET4 to promoters. MET28 acts to stabilise the complex. - - - - - - - psi-mi:"MI:0469"(IntAct) P17106(2)|P32389(0)|P40573(0) +CPX-1018 DRS2-CDC50 P4-ATPase complex Aminophospholipid translocase complex|APLT complex|DRS2-CDC50 phospholipid flippase complex 559292 P25656(0)|P39524(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-13642102 GO:0005524(ATP binding)|GO:0140326(ATPase-coupled intramembrane lipid transporter activity)|GO:1990531(phospholipid-translocating ATPase complex)|GO:0045332(phospholipid translocation) pubmed:27458383(see-also)|intenz:3.6.3.1(identity)|complex portal:CPX-1018(complex-primary) A membrane pump which actively translocates, or flips, phospholipids across cell membranes from the exoplasmic to the cytoplasmic leaflet of the lipid bilayer. This generates and maintains membrane lipid asymmetry, a property essential for a wide variety of cellular processes such as vesicle budding and intracellular vesicle trafficking. Transport is accomplished by cyclic changes between two main enzyme conformations, during which the DRS2 ATPase is phosphorylated by ATP at a conserved aspartate residue (Asp-560) and subsequently dephosphorylated. These processes are coupled to vectorial transport and counter-transport by a controlled opening and closing of cytoplasmic and exoplasmic pathways, which give access to the ion-binding sites that are buried inside the membrane-spanning region of the pump The membrane domain of DRS2 serves as the pathway for translocation of lipid substrates across cell membranes and is predicted to contain 10 transmembrane segments. CDC50 is a membrane glycoprotein and appears to contact DRS2 at multiple sites to promote correct protein folding, exit of the P4-ATPase complex from the endoplasmic reticulum, and formation of a functionally active flippase complex. - - - - - - psi-mi:"MI:0469"(IntAct) P25656(0)|P39524(0) +CPX-1021 DNF1-LEM3 P4-ATPase complex DNF1-LEM3 phospholipid flippase complex|LEM3-DNF1 complex|Aminophospholipid translocase complex|APLT complex 559292 P32660(0)|P42838(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-1560179 GO:0005524(ATP binding)|GO:0140326(ATPase-coupled intramembrane lipid transporter activity)|GO:1990531(phospholipid-translocating ATPase complex)|GO:0045332(phospholipid translocation) intenz:3.6.3.1(identity)|pubmed:27458383(see-also)|complex portal:CPX-1021(complex-primary) A membrane pump which actively translocates, or flips, phospholipids across cell membranes from the exoplasmic to the cytoplasmic leaflet of the lipid bilayer. This generates and maintains membrane lipid asymmetry, a property essential for a wide variety of cellular processes such as vesicle budding and intracellular vesicle trafficking. Transport is accomplished by cyclic changes between two main enzyme conformations, during which the DNF1 ATPase is phosphorylated by ATP at a conserved aspartate residue (Asp-667) and subsequently dephosphorylated. These processes are coupled to vectorial transport and counter-transport by a controlled opening and closing of cytoplasmic and exoplasmic pathways, which give access to the ion-binding sites that are buried inside the membrane-spanning region of the pump. Also involved in transport of the tryptophan permease TAT2 to the plasma membrane. The membrane domain of DNF1 serves as the pathway for translocation of lipid substrates across cell membranes and is predicted to contain 10 transmembrane segments. LEM3 is a membrane glycoprotein. - - - - - - psi-mi:"MI:0469"(IntAct) P32660(0)|P42838(0) +CPX-1022 DNF2-LEM3 P4-ATPase complex DNF2-LEM3 phospholipid flippase complex|LEM3-DNF2 complex|Aminophospholipid translocase complex|APLT complex 559292 P42838(0)|Q12675(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-13643410 GO:0005524(ATP binding)|GO:0140326(ATPase-coupled intramembrane lipid transporter activity)|GO:1990531(phospholipid-translocating ATPase complex)|GO:0045332(phospholipid translocation) intenz:3.6.3.1(identity)|pubmed:27458383(see-also)|complex portal:CPX-1022(complex-primary) A membrane pump which actively translocates, or flips, phospholipids across cell membranes from the exoplasmic to the cytoplasmic leaflet of the lipid bilayer. This generates and maintains membrane lipid asymmetry, a property essential for a wide variety of cellular processes such as vesicle budding and intracellular vesicle trafficking. Transport is accomplished by cyclic changes between two main enzyme conformations, during which the DNF2 ATPase is phosphorylated by ATP at a conserved aspartate residue (Asp-712) and subsequently dephosphorylated. These processes are coupled to vectorial transport and counter-transport by a controlled opening and closing of cytoplasmic and exoplasmic pathways, which give access to the ion-binding sites that are buried inside the membrane-spanning region of the pump. Also involved in transport of the tryptophan permease TAT2 to the plasma membrane. The membrane domain of DNF2 serves as the pathway for translocation of lipid substrates across cell membranes and is predicted to contain 10 transmembrane segments. LEM3 is a membrane glycoprotein. - - - - - - psi-mi:"MI:0469"(IntAct) P42838(0)|Q12675(0) +CPX-1026 DNF3-CRF1 P4-ATPase complex DNF3-CRF1 phospholipid flippase complex|CRF1-DNF3 complex|Aminophospholipid translocase complex|APLT complex 559292 P53740(0)|Q12674(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-13643595 GO:0005524(ATP binding)|GO:0140326(ATPase-coupled intramembrane lipid transporter activity)|GO:1990531(phospholipid-translocating ATPase complex)|GO:0045332(phospholipid translocation) pubmed:27458383(see-also)|intenz:3.6.3.1(identity)|complex portal:CPX-1026(complex-primary) A membrane pump which actively translocates, or flips, phospholipids across cell membranes from the exoplasmic to the cytoplasmic leaflet of the lipid bilayer. This generates and maintains membrane lipid asymmetry, a property essential for a wide variety of cellular processes such as vesicle budding and intracellular vesicle trafficking. Transport is accomplished by cyclic changes between two main enzyme conformations, during which the DNF3 ATPase is phosphorylated by ATP at a conserved aspartate residue (Asp-566) and subsequently dephosphorylated. These processes are coupled to vectorial transport and counter-transport by a controlled opening and closing of cytoplasmic and exoplasmic pathways, which give access to the ion-binding sites that are buried inside the membrane-spanning region of the pump. The membrane domain of DNF3 serves as the pathway for translocation of lipid substrates across cell membranes and is predicted to contain 10 transmembrane segments. YNR048W is a membrane glycoprotein. - - - - - - psi-mi:"MI:0469"(IntAct) P53740(0)|Q12674(0) +CPX-1028 NEO1-MON2-ARL1-DOP1 membrane remodeling complex - 559292 P38116(0)|P40527(0)|P48563(0)|Q03921(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0140326(ATPase-coupled intramembrane lipid transporter activity)|GO:0098629(trans-Golgi network membrane organization)|GO:0010008(endosome membrane) pubmed:20477991(see-also)|intenz:3.6.3.1(identity)|complex portal:CPX-1028(complex-primary) Functions in vesicle trafficking within the Golgi/endosomal system with a putative role in membrane remodeling at the tubular endosomal network and the trans-Golgi network interface - - - - - - - psi-mi:"MI:0469"(IntAct) P38116(0)|P40527(0)|P48563(0)|Q03921(0) +CPX-1036 DNA mismatch repair MutSbeta complex MSH2-MSH3 complex 559292 P25336(1)|P25847(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-1368866 GO:0006298(mismatch repair)|GO:0032302(MutSbeta complex)|GO:0030983(mismatched DNA binding) complex portal:CPX-1036(complex-primary)|pubmed:10915870(see-also)|pubmed:17592146(see-also)|pubmed:15920474(see-also) Mismatch repair complex, involved in the recognition and repair of insertion/deletion mismatches. Active in both targeted gene replacement in which a targeted sequence in the genome is replaced with a selectable gene from a linear targeting DNA, and the single-strand annealing pathway of recombination between direct repeats. Direct repeats flanking a double-stranded break is annealed by RAD52 (P06778) and further stabilized by MSH2-MSH3 which has similar activities on both the leading and lagging strands of replication. MSH2-MSH3 appear to facilitate targeted integration by the two-end invasion pathway while simultaneously inhibiting the single-strand assimilation pathway. - Heterodimer - - - - - psi-mi:"MI:0469"(IntAct) P25336(1)|P25847(1) +CPX-1037 DNA mismatch repair MutSalpha complex MSH2-MSH6 complex 559292 P25847(1)|Q03834(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-1368909 GO:0016887(ATPase activity)|GO:0006298(mismatch repair)|GO:0030983(mismatched DNA binding)|GO:0032301(MutSalpha complex)|GO:0005524(ATP binding) complex portal:CPX-1037(complex-primary)|pubmed:10915870(see-also)|pubmed:10347163(see-also)|pubmed:17592146(see-also) Mismatch repair complex, involved in the recognition and repair of base-base and small insertion/deletion mismatches that appear as a consequence of DNA polymerase errors during DNA synthesis. The complex is most effective at repairing mismatches on the lagging strand of replication. Binding to a mismatched DNA which can bend, leads to stable association of MSH2 with DNA, inhibition of its ATP activity and formation of ATP-bound MSH2-MSH6 sliding clamps. When MSH6 is bound to mismatched DNA and MSH2 to ATP, the complex can recruit MutLalpha and initiate the repair process. Binding of MSH2-MSH6 to a mismatch and provides a recognition signal for interactions with repair proteins that are involved in subsequent steps. - Heterodimer - - - - - psi-mi:"MI:0469"(IntAct) P25847(1)|Q03834(1) +CPX-1038 PIP2-OAF1 transcription factor complex OAF complex|Pip2p-Oaf1p complex 559292 P39720(1)|P52960(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-970017 GO:0005667(transcription regulator complex)|GO:0043565(sequence-specific DNA binding)|GO:0006355(regulation of transcription, DNA-templated)|GO:0006631(fatty acid metabolic process)|GO:0007031(peroxisome organization)|GO:0005634(nucleus) complex portal:CPX-1038(complex-primary)|pubmed:10359602(see-also)|pubmed:12748191(see-also) Acts as a transcriptional activator to induce the transcription of genes encoding proteins involved in fatty acid beta-oxidation, a response called oleic acid induction, when cells grow on fatty acids as the sole carbon source. Recognizes and binds to the oleate response element (ORE or peroxisome box), two inverted CGG triplets spaced by 14 to 18 intervening nucleotides recently refined to CGGN3TNA/(R)N8-12CCG, in the promoter region of a number of peroxisomal genes. Activity is inhibited by OAF1 under non-inducing conditions and repressed by glucose. - Heterodimer - - - - - psi-mi:"MI:0469"(IntAct) P39720(1)|P52960(1) +CPX-1039 COMPASS complex Complex proteins associated with Set1|Set1 complex|Set1C 559292 P36104(1)|P38123(1)|P38337(1)|P38827(2)|P39706(1)|P43132(2)|Q03012(2)|Q03323(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-1370464 GO:0048188(Set1C/COMPASS complex)|GO:0042800(histone methyltransferase activity (H3-K4 specific))|GO:0051568(histone H3-K4 methylation)|GO:0006348(chromatin silencing at telomere)|GO:0005634(nucleus) complex portal:CPX-1039(complex-primary)|pubmed:16980427(see-also)|intenz:2.1.1.43(identity)|pubmed:16582434(see-also)|pubmed:12764140(see-also) Histone methyltransferase that catalyzes methylation of Lys-4 of histone H3 and thus controls the silencing of telomeric regions. SWD1, SWD3, and SET1 constitute a core of the complex, and the absence of any of these subunits abolishes methylation of lysine 4 on histone H3. Subunits BRE2 and SDC1 are essential for trimethylation and important for mono- and dimethylation by the COMPASS complex. SPP1 is important for trimethylation, while SHG1 plays a minor role in trimethylation. MW = 1MDa Heteroundecamer - - - - - psi-mi:"MI:0469"(IntAct) P36104(1)|P38123(1)|P38337(1)|P38827(2)|P39706(1)|P43132(2)|Q03012(2)|Q03323(1) +CPX-1040 SKI complex Ski2p-Ski3p-Ski8p complex 559292 P17883(1)|P35207(1)|Q02793(2) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-1371221 GO:0003724(RNA helicase activity)|GO:0005524(ATP binding)|GO:0055087(Ski complex)|GO:0016887(ATPase activity)|GO:0003723(RNA binding)|GO:0034427(nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5')|GO:0006402(mRNA catabolic process) wwpdb:4BUJ(identity)|intenz:3.6.4.13(identity)|complex portal:CPX-1040(complex-primary)|rhea:RHEA:13065(identity) Central component of the 3'-5' cytoplasmic mRNA degradation pathway which interacts with Ski7 (Q08491) to mediate degradation by the exosome. The Ski complex appears to thread RNAs directly to the exosome, coupling the helicase and the exoribonuclease through a continuous RNA channel. Ski3 forms an array of 33 TPR motifs organized in N-terminal and C-terminal arms. The C-terminal arm of Ski3 and the two Ski8 subunits position the helicase core of Ski2 centrally within the complex, enhancing RNA binding. The Ski3 N-terminal arm and the Ski2 insertion domain allosterically modulate the ATPase and helicase activities of the complex. MW = 370-380kDa Heterotetramer - - - - - psi-mi:"MI:0469"(IntAct) P17883(1)|P35207(1)|Q02793(2) +CPX-1041 DASH complex Dam-Duo complex|Dam1 protein complex|DDD complex|Duo1p/Dam1p complex 559292 P35734(1)|P36131(1)|P36162(1)|P53168(1)|P53267(1)|P69850(1)|P69851(1)|P69852(1)|Q03954(1)|Q12248(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-1379812 GO:0072686(mitotic spindle)|GO:0051987(positive regulation of attachment of spindle microtubules to kinetochore)|GO:0008017(microtubule binding)|GO:1990758(mitotic sister chromatid biorientation)|GO:0042729(DASH complex) complex portal:CPX-1041(complex-primary)|pubmed:17460120(see-also)|pubmed:15632076(see-also) Heterodecameric component of the kinetochore necessary for accurate chromosome segregation, supporting the dynamic attachment of mitotic chromosomes to the ends of shortening spindle microtubules. DASH forms closed rings around microtubules with a large gap between the DASH ring and the microtubule cylinder. A DASH-microtubule interface is believed to form, in which extensions from DASH rings reach across a gap between the ring and the microtubule and dock on the microtubule wall. DASH rings spontaneously oligomerize in the presence of microtubules of the mitotic spindle. DASH rings are processivity factors that allow kinetochores to translate along a single microtubule without dissociating. Each DASH ring may contain from 16-30 heterodecamers. The NDC80 complex (CPX-548) can simultaneously bind and bridge across two DASH complex rings through a tripartite interaction, each component of which is regulated by IPL1 kinase (P38991). This ensures a consistent spacing between rings. The complex may also may serve as a link between the kinetochore and the mitotic spindle. MW of the heterodecamer = 211 +/- 16 kDa, MW of the DASH ring = 5 MDa. The heterodecamer is relatively globular in solution with a 130-150 A diameter. The Stokes radius of 76 A is larger than expected for a 200-kDa protein. Along with the calculated frictional coefficient of 1.90, this suggests either an elongated shape or the presence of unstructured extensions. EM images suggest a 16-fold symmetry. Heterodecamer - - - - - psi-mi:"MI:0469"(IntAct) P35734(1)|P36131(1)|P36162(1)|P53168(1)|P53267(1)|P69850(1)|P69851(1)|P69852(1)|Q03954(1)|Q12248(1) +CPX-1042 GAL3-GAL80 transcription regulation complex - 559292 CHEBI:28061(2)|CHEBI:30617(2)|P04387(2)|P13045(2) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-13916429 GO:0000435(positive regulation of transcription from RNA polymerase II promoter by galactose)|GO:0006012(galactose metabolic process)|GO:0005634(nucleus)|GO:0005667(transcription regulator complex) wwpdb:3v2u(identity)|pubmed:25220841(see-also)|complex portal:CPX-1042(complex-primary) Acts to relieve the repression of the GAL4 positive regulator of gene expression. The GAL network is a small set of genes that regulates galactose import and metabolism. The transcriptional activator GAL4 activates a set of enzymatic and regulatory genes by binding to their promoter regions. When galactose is the sole carbon source, the galactose-metabolizing enzymes are expressed at 1000 times their level in glucose. In the absence of galactose, GAL4 activity is repressed by forming a complex with the transcriptional repressor GAL80 (CPX-1044). In the presence of galactose and ATP, the GAL3-GAL80 complex forms, removing GAL80 from the GAL4-activation domain, which is then able to recruit the transcriptional machinery. It is also possible a tripartite complex forms (GAL4-GAL80-GAL3), which counterbalances the effect of GAL80 on GAL4 and allows GAL4 to interact with promoters. GAL3 primarily binds with ATP and galactose in the cytoplasm, then moves into the nucleus to interact with GAL80. A paralogous complex, GAL1-GAL80 (CPX-1043) can also form but appears to have lower activity as a transcriptional inducer of GAL genes. It is possible that GAL3-GAL80 may be involved solely in the short-term response to galactose and GAL1-GAL80 is required for continued expression of the GAL genes. The interaction between the two GAL80 occurs largely through the interaction between two large beta-sheets, forming a very extensive dimerization surface. The interaction between the two GAL3 molecules is less extensive and occurs largely through water molecules.The GAL3-GAL80 interaction occurs through a complex network of hydrogen bonds. GAL3 binds galactose and Mg2+-ATP, which induce the closed conformation of the protein and enables GAL80 binding. A 2543 A2 surface area gets buried when a dimer of GAL80 binds the two monomers of GAL3, and an additional 647 A2 is buried due to GAL80-induced GAL3 dimer formation. Heterotetramer - - - - - psi-mi:"MI:0469"(IntAct) P04387(2)|P13045(2) +CPX-1043 GAL1-GAL80 transcription regulation complex - 559292 CHEBI:28061(2)|CHEBI:30617(2)|P04385(2)|P04387(2) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-13916594 GO:0000435(positive regulation of transcription from RNA polymerase II promoter by galactose)|GO:0006012(galactose metabolic process)|GO:0005634(nucleus)|GO:0005667(transcription regulator complex) pubmed:25220841(see-also)|complex portal:CPX-1043(complex-primary) Acts to relieve the repression of the GAL4 positive regulator of gene expression. The GAL network is a small set of genes that regulates galactose import and metabolism. The transcriptional activator GAL4 activates a set of enzymatic and regulatory genes by binding to their promoter regions. When galactose is the sole carbon source, the galactose-metabolizing enzymes are expressed at 1000 times their level in glucose. In the absence of galactose, GAL4 activity is repressed by forming a complex with the transcriptional repressor GAL80 (CPX-1044). In the presence of galactose and ATP, the GAL1-GAL80 complex forms, removing GAL80 from the GAL4-activation domain, which is then able to recruit the transcriptional machinery. It is also possible a tripartite complex forms (GAL4-GAL80-GAL1), which counterbalances the effect of GAL80 on GAL4 and allows GAL4 to interact with promoters. GAL1 primarily binds with ATP and galactose in the cytoplasm, then moves into the nucleus to interact with GAL80. A paralogous complex, GAL3-GAL80 (CPX-1042) can also form and appears to have significantly higher activity as a transcriptional inducer of GAL genes. The importance of GAL1-GAL80 is unclear as it appears that GAL1 is not sufficiently expressed in the absence of galactose to serve as an inducer but other evidence suggests the complex may be required for the continued expression of the GAL genes. The interaction between the two GAL80 occurs largely through the interaction between two large beta-sheets, forming a very extensive dimerization surface. There is a limited interface between GAL80 and GAL1 which restricts the flexibility of GAL80. Heterotetramer - - - - - psi-mi:"MI:0469"(IntAct) P04385(2)|P04387(2) +CPX-1044 GAL4-GAL80 transcription repressor complex - 559292 CHEBI:15846(2)|P04386(2)|P04387(2) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-13916649 GO:0000431(negative regulation of transcription from RNA polymerase II promoter by galactose)|GO:0006012(galactose metabolic process)|GO:0005634(nucleus)|GO:0017053(transcription repressor complex) wwpdb:3BTS(identity)|complex portal:CPX-1044(complex-primary) Acts to repress the GAL4 positive regulator of gene expression. The GAL network is a small set of genes that regulates galactose import and metabolism. The transcriptional activator GAL4 activates a set of enzymatic and regulatory genes by binding to their promoter regions. When galactose is the sole carbon source, the galactose-metabolizing enzymes are expressed at 1000 times their level in glucose. In the absence of galactose, GAL4 activity is repressed by forming a complex with the transcriptional repressor GAL80. In the presence of galactose and ATP, the GAL3-GAL80 complex (CPX-1042) forms, removing GAL80 from the GAL4-activation domain, which is then able to recruit the transcriptional machinery. It is also possible a tripartite complex forms (GAL4-GAL80-GAL3), which counterbalances the effect of GAL80 on GAL4 and allows GAL4 to interact with promoters. GAL3 primarily binds with ATP and galactose in the cytoplasm, then moves into the nucleus to interact with GAL80. A paralogous complex, GAL1-GAL80 (CPX-1043) can also form but appears to have lower activity as a transcriptional inducer of GAL genes. It is possible that GAL3-GAL80 may be involved solely in the short-term response to galactose and GAL1-GAL80 is required for continued expression of the GAL genes. The interaction between the two GAL80 occurs largely through the interaction between two large beta-sheets, forming a very extensive dimerization surface. NAD+ facilitates Gal80 binding to Gal4, while NADP+ destabilizes this interaction and may be the initial trigger for Gal4 activation. - - - - - - psi-mi:"MI:0469"(IntAct) P04386(2)|P04387(2) +CPX-1045 ERV41-ERV46 retrograde receptor complex - 559292 P39727(0)|Q04651(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-7740947 GO:0006890(retrograde vesicle-mediated transport, Golgi to ER)|GO:0030176(integral component of endoplasmic reticulum membrane)|GO:0030173(integral component of Golgi membrane)|GO:0061852(retrograte transporter complex, Golgi to ER) complex portal:CPX-1045(complex-primary) Transporter complex that recognises, binds and returns endoplasmic reticulum (ER) resident proteins that have trafficked to Golgi compartments. Targets proteins lacking the HDEL motif recognised by COPI-coated vesicles. Transported back to the Golgi by COPII (CPX-2523) for the next round of retrograde transport. Both subunits contain COPII sorting motifs on their C-termini, and ERV46 additionally contains a conserved C-terminal COPI binding dilysine motif. - - - - - - psi-mi:"MI:0469"(IntAct) P39727(0)|Q04651(0) +CPX-1047 BUD23-TRM112 methyltransferase complex S-adenosylmethionine-dependent methyltransferase complex|S-adenosyl-L-methionine-dependent methyltransferase complex|SAM-dependent methyltransferase complex 559292 P25627(1)|P53738(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-13918574 GO:0008757(S-adenosylmethionine-dependent methyltransferase activity)|GO:0070043(rRNA (guanine-N7-)-methyltransferase activity)|GO:1904047(S-adenosyl-L-methionine binding)|GO:1990275(preribosome binding)|GO:0070476(rRNA (guanine-N7)-methylation)|GO:0043527(tRNA methyltransferase complex) wwpdb:4QTU(identity)|intenz:2.1.1.309(identity)|wwpdb:4QTT(identity)|complex portal:CPX-1047(complex-primary)|pubmed:28134793(see-also) S-adenosylmethionine-dependent methyltransferase which plays a role in the synthesis of the small ribosomal subunit by catalyzing the N7-methylation of guanosine-1575 of 18S rRNA at the 20S pre-rRNA stage. The complex interacts with the box C/D snoRNA U3-associated DEAH RNA helicase DHR1, which appears to play a role in central pseudoknot formation, so may also contribute to controlling the folding of small subunit rRNA. May play a role in 40S ribosome maturation. TRM112 stabilizes BUD23 through the formation of a beta-zipper, which masks an important solvent-unfavorable hydrophobic surface on BUD23, and undergoes an induced fit to accommodate BUD23 binding. Large steric clashes between BUD23-TRM112 and ribosomal components suggest this complex cannot bind mature ribosomes and has to dissociate from the 40S subunit before completion of its biosynthesis. - s-adenosyl-l-methionine (CHEBI:15414) - - - - psi-mi:"MI:0469"(IntAct) P25627(1)|P53738(1) +CPX-1052 TRM9-TRM112 methyltransferase complex S-adenosylmethionine-dependent methyltransferase complex|S-adenosyl-L-methionine-dependent methyltransferase complex|SAM-dependent methyltransferase complex 559292 P49957(0)|P53738(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-13921939 GO:0016300(tRNA (uracil) methyltransferase activity)|GO:0043527(tRNA methyltransferase complex)|GO:0002098(tRNA wobble uridine modification)|GO:0000049(tRNA binding) intenz:2.1.1.229(identity)|complex portal:CPX-1052(complex-primary)|pubmed:28134793(see-also) S-adenosylmethionine-dependent methyltransferase involved in the formation of mcm5(s2)U (5-methoxycarbonylmethyl(2-thio)uridine) modifications at position 34 from the anticodon loop of some tRNAs. This modification is present at the wobble position of tRNAArg(UCU), tRNAGly(UCC), tRNALys(UUU), tRNAGln(UUG) and tRNAGlu(UUC). Modifications in the anticodon loop of tRNAs are known to influence the translation rate and fidelity of decoding. - - - - - - - psi-mi:"MI:0469"(IntAct) P49957(0)|P53738(0) +CPX-1053 Cleavage and polyadenylation specificity factor complex CPSF complex|Cleavage and polyadenylation factor complex|CPF complex 559292 CHEBI:18420(2)|CHEBI:29035(2)|CHEBI:29105(2)|P29468(0)|P32598(1)|P35728(0)|P36104(0)|P39927(0)|P42073(1)|P42841(0)|P45976(0)|P53538(0)|Q01329(1)|Q06102(0)|Q06224(0)|Q06632(0)|Q08553(1)|Q12102(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-3401931 GO:0006378(mRNA polyadenylation)|GO:0003723(RNA binding)|GO:0005847(mRNA cleavage and polyadenylation specificity factor complex)|GO:0098789(pre-mRNA cleavage required for polyadenylation)|GO:0016892(endoribonuclease activity, producing 3'-phosphomonoesters)|GO:0030846(termination of RNA polymerase II transcription, poly(A)-coupled)|GO:0004722(protein serine/threonine phosphatase activity)|GO:0005524(ATP binding)|GO:0005634(nucleus)|GO:0004652(polynucleotide adenylyltransferase activity) intenz:3.1.27(identity)|intenz:2.7.7.19(identity)|wwpdb:3C66(subset)|complex portal:CPX-1053(complex-primary)|pubmed:29074584(see-also)|wwpdb:6eoj(identity)|emdb:EMD-3908(identity)|intenz:3.1.3.16(identity) Endonuclease complex required for mRNA 3-prime end processing to form a defined 3-prime end of the transcribed RNA. The complex cleaves pre-mRNAs, adds a polyadenylate tail, and triggers transcription termination. The 3-prime end of mature mRNAs is generated by a site-specific endonucleolytic cleavage of an internal phosphodiester bond of the primary transcript by YSH1. The upstream cleavage product generated is then polyadenylated by PAP1 to form a 50-90 adenosine tail at its 3-prime hydroxyl end, which is required for nuclear export, translation, and stability of mRNA. The downstream cleavage product is rapidly degraded. Cleavage and polyadenylation cycles are regulated by phosphorylation/dephosphorylation. Phosphorylation of CPF is inhibitory to polyadenylation therefore dephosphorylation of CPF by GLC7 is required to switch the processing complex to one competent for poly(A) addition. The nuclease, polymerase, and phosphatase activities of the CPF complex are organized into three modules. The poly(A) polymerase module contains five subunits: CFT1, PFS2, PAP1, FLP1, and YTH1 CFT1 forms the core of the complex and is composed of three seven-bladed beta-propellers followed by a C-terminal helical domain. The nuclease module is composed of three subunits (YSH1, CFT2, and MPE1), whereas the phosphatase module contains seven subunits (PTA1, REF2, PTI1, SWD2, GLC7, SSU72, and SYC1). The modules may be held together by hydrophobic interactions which may be dynamic. - - - - - - psi-mi:"MI:0469"(IntAct) P29468(0)|P32598(1)|P35728(0)|P36104(0)|P39927(0)|P42073(1)|P42841(0)|P45976(0)|P53538(0)|Q01329(1)|Q06102(0)|Q06224(0)|Q06632(0)|Q08553(1)|Q12102(0) +CPX-1068 Importin complex, KAP60-KAP95 Importin complex alpha-beta|Karyopherin complex|IMA5-IMB1 complex 559292 Q02821(1)|Q06142(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-1173514 GO:0005829(cytosol)|GO:0051170(import into nucleus)|GO:0061608(nuclear import signal receptor activity)|GO:0042564(NLS-dependent protein nuclear import complex)|GO:0005635(nuclear envelope) pubmed:9412461(see-also)|complex portal:CPX-1068(complex-primary) A nuclear import complex that functions as a nuclear import receptor for proteins containing a nuclear localisation signal (NLS). Subunit SRP1 specifically and directly binds to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KAP95. KAP95 binds to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, GSP1-dependent mechanism. At the nucleoplasmic side of the NPC, GSP1-GTP (P32835) binds to KAP95, the three components separate and SRP1 and KAP95 are re-exported from the nucleus to the cytoplasm where GTP is hydrolysed. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of GSP1 between the cytoplasm and nucleus. - - - - - - - psi-mi:"MI:0469"(IntAct) Q02821(1)|Q06142(1) +CPX-1071 RecQ helicase-Topo III complex Sgs1-Top3 Complex|Sgs1-Top3-Rmi1 complex|STR complex|RecQ helicase-Topo3 complex|BTR complex 559292 P13099(0)|P35187(0)|Q02685(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-13946338 GO:0003917(DNA topoisomerase type I activity)|GO:0043138(3'-5' DNA helicase activity)|GO:0000724(double-strand break repair via homologous recombination)|GO:0009378(four-way junction helicase activity)|GO:0000400(four-way junction DNA binding)|GO:0031422(RecQ helicase-Topo III complex)|GO:0003697(single-stranded DNA binding) pubmed:20935631(see-also)|intenz:5.99.1.2(identity)|intenz:3.6.4.12(identity)|complex portal:CPX-1071(complex-primary) Required for both the early and late steps of DNA double-strand break (DSB) via dissolution of double Holliday junctions. Early in the repair of a two-ended DSB, the complex contributes to DSB end resection by facilitating the formation of a single-strand 3-prime overhang on which the homologous recombination (HR) factor Rad51 (P25454) filament assembles. The complex has also been implicated in the unwinding of strand invasion after extension of the invading 3-prime end by DNA synthesis to promote DSB repair by synthesis-dependent strand annealing, as well as reversal of strand invasion prior to 3-prime end extension. Through these functions, the complex promotes non-crossover outcomes of HR and regulates HR levels. - - - - - - - psi-mi:"MI:0469"(IntAct) P13099(0)|P35187(0)|Q02685(0) +CPX-1091 DNA polymerase zeta complex - 559292 CHEBI:49883(0)|P14284(0)|P38927(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-973833 GO:0016035(zeta DNA polymerase complex)|GO:0005739(mitochondrion)|GO:0003887(DNA-directed DNA polymerase activity)|GO:0042276(error-prone translesion synthesis) intenz:2.7.7.7(identity)|complex portal:CPX-1091(complex-primary) Low-fidelity non-essential DNA polymerase that is involved in translesion DNA synthesis. Required for the majority of spontaneous mutagenesis in wild-type yeast cells, as well as for mutagenesis associated with transcription, with double-strand break repair, and with defective DNA repair. - - - - - - - psi-mi:"MI:0469"(IntAct) P14284(0)|P38927(0) +CPX-1101 RNA polymerase I upstream activating factor complex RNA polymerase I UAF|UAF|upstream activating factor complex 559292 P02309(0)|P38204(0)|P53437(0)|P61830(0)|Q02983(0)|Q08747(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-1396134 GO:0042790(nucleolar large rRNA transcription by RNA polymerase I)|GO:0005634(nucleus)|GO:0001165(RNA polymerase I upstream control element sequence-specific DNA binding)|GO:0000500(RNA polymerase I upstream activating factor complex)|GO:0045943(positive regulation of transcription by RNA polymerase I) complex portal:CPX-1101(complex-primary)|pubmed:14969726(see-also)|pubmed:16648483(see-also)|pubmed:16002464(see-also) Binds tightly to the upstream element of the yeast Pol I promoter and is essential for a high level of transcription of the 35S rRNA gene. UAF has dual functions: both as a positive transcription factor for Pol I, and as a silencer for Pol II transcription of rRNA genes. Deletion of any one of the subunit protein genes encoding essential nonhistone proteins causes derepression of Pol II transcription of the 35S rRNA genes. The association of H3 and H4 with the other UAF components is important for the stability of UAF in vivo and, hence, for rRNA transcription by Pol I. Initiation of transcription requires the assembly of UAF, the core factor (CPX-1836), the TATA binding protein SPT15 (P13393), and RNAP-I (CPX-1664) with RRN3 (P36070) on the upstream element and core promoter. Upon transcription initiation, UAF, RRN3 and CF dissociate from the promoter. MW = 200 kDa - - - - - - psi-mi:"MI:0469"(IntAct) P02309(0)|P38204(0)|P53437(0)|P61830(0)|Q02983(0)|Q08747(0) +CPX-1102 Ribonucleoside-diphosphate reductase variant 1 Ribonucleotide-diphosphate reductase|Ribonucleotide reductase|RNR|2'-deoxyribonucleoside-diphosphate:oxidized-thioredoxin 2'-oxidoreductase|Ribonucleoside 5'-diphosphate reductase|Ribonucleoside diphosphate reductase|Ribonucleotide diphosphate reductase 559292 CHEBI:24875(2)|P09938(1)|P21524(2)|P49723(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-1396608 GO:0005971(ribonucleoside-diphosphate reductase complex)|GO:0009263(deoxyribonucleotide biosynthetic process)|GO:0004748(ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor)|GO:0005524(ATP binding)|GO:0005737(cytoplasm) complex portal:CPX-1102(complex-primary)|pubmed:16537480(see-also)|pubmed:16537479(see-also)|intenz:1.17.4.1(identity)|wwpdb:1JK0(subset) Catalyzes the reduction of ribonucleotides to the corresponding deoxyribonucleotides, an essential step in the de novo synthesis of monomeric precursors for DNA replication and repair. The catalytically active form is an alpha2beta2 tetramer. The homodimeric alpha subunit, called R1, houses the active site, composed of redox-active disulfides, and binding sites for allosteric effectors, ribonucleoside diphosphates. The beta subunit, called R2, contains a di-iron cluster that in its reduced state reacts with dioxygen to form a stable tyrosyl radical (Y*) and a di-iron(III) cluster. This essential Y* is proposed to generate a thiyl radical, located on a cysteine residue in the R1 active site, that initiates ribonucleotide reduction. The enzyme is allosterically controlled by relative levels of dNTPs. This variant is found in all cell states, a related variant (CPX-1103) is only found in damaged or growth-arrested cells. the small subunit, RNR2-RNR4, is nuclear while the large subunit, RNR1, is cytoplasmic. In response to S-phase or DNA-damage, RNR2-RNR4 enters the cytoplasm to bind RNR1. Sedimention coefficient = 9.7 S Heterotetramer - - - - - psi-mi:"MI:0469"(IntAct) P09938(1)|P21524(2)|P49723(1) +CPX-1103 Ribonucleoside-diphosphate reductase variant 2 Ribonucleotide-diphosphate reductase|ribonucleotide reductase|RNR|Ribonucleoside 5'-diphosphate reductase|2'-deoxyribonucleoside-diphosphate:oxidized-thioredoxin 2'-oxidoreductase|Ribonucleoside diphosphate reductase|Ribonucleotide diphosphate reductase 559292 CHEBI:24875(2)|P09938(1)|P21524(1)|P21672(1)|P49723(1) ECO:0005546(biological system reconstruction evidence based on paralogy evidence used in manual assertion) - GO:0009263(deoxyribonucleotide biosynthetic process)|GO:0005737(cytoplasm)|GO:0004748(ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor)|GO:0005524(ATP binding)|GO:0005971(ribonucleoside-diphosphate reductase complex) complex portal:CPX-1103(complex-primary)|complex portal:CPX-1102(inferred-from)|pubmed:16537480(see-also)|pubmed:16537479(see-also)|intenz:1.17.4.1(identity)|wwpdb:1JK0(subset) Catalyzes the reduction of ribonucleotides to the corresponding deoxyribonucleotides, an essential step in the de novo synthesis of monomeric precursors for DNA replication and repair. The catalytically active form of the enzyme (CPX-1102) is an alpha2beta2 tetramer. The heterodimeric alpha subunits, called R1, house the active site, composed of redox-active disulfides, and binding sites for allosteric effectors, ribonucleoside diphosphates. The beta subunit, called R2, contains a di-iron cluster that in its reduced state reacts with dioxygen to form a stable tyrosyl radical (Y*) and a di-iron(III) cluster. This essential Y* is proposed to generate a thiyl radical, located on a cysteine residue in the R1 active site, that initiates ribonucleotide reduction. The enzyme is allosterically controlled by relative levels of dNTPs. In damaged cells or cells arrested for DNA synthesis, the small subunits (RNR2-RNR4) associate with a heterodimer of RNR1 and the damage-inducible RNR3. - Heterotetramer - - - - - psi-mi:"MI:0469"(IntAct) P09938(1)|P21524(1)|P21672(1)|P49723(1) +CPX-1125 BUG1-GRH1 complex - 559292 Q04410(0)|Q12191(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-14061175 GO:0106103(COPII vesicles tethering complex)|GO:0007030(Golgi organization)|GO:0033106(cis-Golgi network membrane) pubmed:21482742(see-also)|complex portal:CPX-1125(complex-primary) Appears to play a role in the tethering of COPII (CPX-2523), though an interaction with Sec23/24, and thus formation of the cis-Golgi and endoplasmic reticulum to Golgi vesicle-mediated transport. The complex is anchored to membranes through an acetylated amino-terminal region in Grh1. - - - - - - - psi-mi:"MI:0469"(IntAct) Q04410(0)|Q12191(0) +CPX-1140 HICS complex - 559292 P40073(0)|P53901(0)|Q05080(0)|Q07533(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0044697(HICS complex)|GO:0005935(cellular bud neck)|GO:1902410(mitotic cytokinetic process)|GO:0016020(membrane) complex portal:CPX-1140(complex-primary) Appears to have a role in cytokinesis. May connect the actin-myosin ring to the plasma membrane. - - - - - - - psi-mi:"MI:0469"(IntAct) P40073(0)|P53901(0)|Q05080(0)|Q07533(0) +CPX-1141 MOT1-TBP transcription regulation complex MOT1 complex 559292 P13393(0)|P32333(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-371689 GO:1990837(sequence-specific double-stranded DNA binding)|GO:0045892(negative regulation of transcription, DNA-templated)|GO:0016887(ATPase activity)|GO:0005524(ATP binding)|GO:0005634(nucleus)|GO:0005667(transcription regulator complex) intenz:3.6.4.-(identity)|pubmed:27255709(see-also)|complex portal:CPX-1141(complex-primary) Transcriptional regulation complex, formation of which causes the dissociation of the TATA-binding protein (TBP) from promoters and thereby regulates TBP distribution in the cell. ATP-driven TBP-DNA dissociation by MOT1 involves both the conversion of MOT1 to an open ATPase state to the closed state induced by ATP binding and short range DNA translocation. May form a larger, DNA-dependent, assembly with the NC2 complex (CPX-1662). - - - - - - - psi-mi:"MI:0469"(IntAct) P13393(0)|P32333(0) +CPX-1142 mRNA nuclear export factor complex, MEX67-MTR2 - 559292 P34232(1)|Q99257(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-15096507 GO:0043023(ribosomal large subunit binding)|GO:0003723(RNA binding)|GO:0042272(nuclear RNA export factor complex)|GO:0006406(mRNA export from nucleus)|GO:0005634(nucleus)|GO:0000055(ribosomal large subunit export from nucleus)|GO:0000056(ribosomal small subunit export from nucleus)|GO:0043024(ribosomal small subunit binding) wwpdb:1of5(identity)|complex portal:CPX-1142(complex-primary)|wwpdb:4WWU(identity) Mediates the export of bulk mRNA through direct interactions with both the mRNA cargo and nuclear pore proteins that contain characteristic phenylalanine-glycine repeating sequence motifs (FG-nucleoporins or FG-nups). Also contributes to ribosomal subunit export. The alignment of the leucine rich repeat and nuclear transport factor 2-like domains of MEX67 functions to generate an extensive positively-charged surface on the molecule that facilitates RNA binding and which positions the mRNA cargo. Heterodimer - - - - - psi-mi:"MI:0469"(IntAct) P34232(1)|Q99257(1) +CPX-1143 Transcription factor TFIIIB complex - 559292 P13393(1)|P29056(1)|P46678(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0000126(transcription factor TFIIIB complex)|GO:0006359(regulation of transcription from RNA polymerase III promoter)|GO:0000995(RNA polymerase III general initiation factor activity)|GO:0043565(sequence-specific DNA binding)|GO:0044374(sequence-specific DNA binding, bending)|GO:0070898(RNA polymerase III transcriptional preinitiation complex assembly) pubmed:23063749(see-also)|wwpdb:1ngm(subset)|complex portal:CPX-1143(complex-primary) Transcription factor complex required for Pol III transcription complex (CPX-2660) assembly which transcribes short noncoding RNA genes. Cooperates with TFIIIC (CPX-1656) to recruit Pol III to different types of gene promoters and form the preinitiation complex (PIC). For PIC formation at transfer DNA (tDNA) genes, TFIIIC recognizes the gene-internal box A and B elements, while TFIIIB localizes further upstream. TFIIIA (P39933) is required only for the transcription of 5S rRNA, where it recognizes the gene-internal control element, box C, to further recruit TFIIIC and TFIIIB. Once assembled upstream of the start site, TFIIIB generates a significant DNA distortion of the class III gene promoter through the SPT15 and BDP1 subunits. - - - - - - - psi-mi:"MI:0469"(IntAct) P13393(1)|P29056(1)|P46678(0) +CPX-1149 Transcription factor TFIIF complex - 559292 P35189(0)|P41895(0)|P41896(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0000977(RNA polymerase II regulatory region sequence-specific DNA binding)|GO:0005674(transcription factor TFIIF complex)|GO:0006355(regulation of transcription, DNA-templated)|GO:0005634(nucleus)|GO:0051123(RNA polymerase II transcriptional preinitiation complex assembly)|GO:0006367(transcription initiation from RNA polymerase II promoter)|GO:0016251(RNA polymerase II general transcription initiation factor activity) pubmed:14749386(see-also)|intenz:3.6.4.12(identity)|pubmed:27193681(see-also)|complex portal:CPX-1149(complex-primary) General transcription factor that interacts with RNAPII and can recruit RNAPII to a preinitiation complex containing TFIID and TFIIB. Required for the opening of DNA, to allow transcription initiation. DNA opening occurs around the tip of the Pol II clamp and the TFIIE (CPX-1658) ‘extended winged helix’ domain. TFIIF and TFIIE bind open promoter DNA from opposite sides of the Pol II cleft. TFIIF adopts an extended induced structure that allows it to retain the upstream DNA–SPT15–TFIIB assembly on the wall and to bind the DNA bubble. TFIIF and TFIIE encircle and retain the DNA and TFIIE may then act to stabilize the open DNA structure. TFG1 and TFG2 C-terminal domains have winged-helix architectures which interact with double-stranded DNA. - - - - - - psi-mi:"MI:0469"(IntAct) P35189(0)|P41895(0)|P41896(0) +CPX-1150 SWI/SNF chromatin remodelling complex SWI/SNF ATP-dependent nucleosome-remodeling complex|SWI/SNF ATP-dependent chromatin remodelling complex|SWItch/Sucrose Non-Fermentable complex 559292 P09547(1)|P18480(1)|P18888(2)|P22082(1)|P32591(2)|P35189(3)|P38956(2)|P43554(2)|P53330(0)|P53628(1)|Q05123(1)|Q12406(1) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0016514(SWI/SNF complex)|GO:0006357(regulation of transcription from RNA polymerase II promoter)|GO:0003690(double-stranded DNA binding)|GO:0006338(chromatin remodeling)|GO:1905168(positive regulation of double-strand break repair via homologous recombination)|GO:0000785(chromatin)|GO:0140658(ATPase-dependent chromatin remodeler activity)|GO:0016887(ATPase activity) intenz:3.6.4.(identity)|complex portal:CPX-1150(complex-primary)|emdb:EMD-6834(identity)|pubmed:28249159(see-also)|pubmed:28637241(see-also)|pubmed:29546678(see-also)|wwpdb:3WEE(subset)|wwpdb:4i6m(subset) An ATP-dependent chromatin remodelling complex which disrupts the nucleosome structure, increases the binding of transcription factors to nucleosomes, mobilizes histone octamers along DNA in cis, transfers histone octamers to different DNA fragments, displaces histone H2A/H2B dimers and generates superhelical torsion in DNA. Binds preferentially to four-way DNA and promotes resection initiation at a DNA double-strand break. Binds to DNA and nucleosomes without any DNA sequence specificity. Molecular weight = 1.14MDa. Assembles around a catalytic subunit that contains a central ATPase domain and flanking sequences that recruit auxiliary subunits. The auxiliary subunits SNF5 and SWI3 ensure nucleosome occupancy at promoters and targeting to histones. RTT102 acts as a stabilizing factor for the Arp7/9 heterodimer, enhancing its interaction with nucleotide. - - - - - - psi-mi:"MI:0469"(IntAct) P09547(1)|P18480(1)|P18888(2)|P22082(1)|P32591(2)|P35189(3)|P38956(2)|P43554(2)|P53330(0)|P53628(1)|Q05123(1)|Q12406(1) +CPX-1151 N-acetylglutamate synthase NAGS/NAGK complex NAGS:NAGK complex|NAGK/NAGS metabolon|N-acetylglutamate synthase/N-acetylglutamate kinase metabolon 559292 P40360(0)|Q01217-PRO_0000002073(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0005759(mitochondrial matrix)|GO:0034618(arginine binding)|GO:0004042(acetyl-CoA:L-glutamate N-acetyltransferase activity)|GO:0003991(acetylglutamate kinase activity)|GO:0006526(arginine biosynthetic process)|GO:0106098(NAGS/NAGK complex) intenz:2.7.2.8(identity)|intenz:2.3.1.1(identity)|complex portal:CPX-1151(complex-primary) Required for the controlling initial step of L-arginine biosynthesis. Forms a metabolon, i.e. a complex formed by the supramolecular association of two sequentially acting enzymes of the pathway that synthesizes N(2)-acetyl-L-ornithine from L-glutamate. Regulated by arginine binding. The ARG5,6 kinase can exist independently of ARG2, ARG2 appears only to exist as a part of the metabolon. ARG5,6 may therefore also act as a chaperone and/or an essential stabilizing agent for ARG2. The ARG5,6 gene encodes a polyprotein precursor which is maturated in the mitochondrial matrix to N-acetylglutamate kinase (PRO_0000002073) and N-acetylglutamylphosphate reductase (PRO_0000002074). Only the kinase component appears to be present in the metabolon complex. - - - - - - psi-mi:"MI:0469"(IntAct) P40360(0)|Q01217-PRO_0000002073(0) +CPX-1152 ARGR-MCM1 transcription regulation complex ARGR complex 559292 P05085(0)|P07249(0)|P07250(0)|P11746(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0090575(RNA polymerase II transcription factor complex)|GO:0000821(regulation of arginine metabolic process)|GO:0005634(nucleus)|GO:0000981(DNA-binding transcription factor activity, RNA polymerase II-specific)|GO:0045944(positive regulation of transcription from RNA polymerase II promoter) complex portal:CPX-1152(complex-primary) Transcriptional regulation complex which binds, in the presence of arginine, to the promoter regions of genes co-regulated by arginine, repressing the synthesis of five anabolic enzymes, e.g. ornithine carbamoyltransferase and inducing the synthesis of two catabolic enzymes, e.g. arginase. The inositol polyphosphate multikinase, ARG82 appears to be required for the recruitment and stability of complex components but its activity in this complex has not been linked to its enzymatic activity. ARG82 is not required for the formation of an arginine-dependent protein-DNA complex in vitro so may not be a component of the mature complex. - - - - - - - psi-mi:"MI:0469"(IntAct) P05085(0)|P07249(0)|P07250(0)|P11746(0) +CPX-1153 BLOC-1 complex Biogenesis of Lysosome-related Organelles Complex-1 559292 P35727(0)|P40003(0)|P48232(0)|P53158(0)|Q06071(0)|Q06333(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-15101443 GO:0007032(endosome organization)|GO:0032880(regulation of protein localization)|GO:0031083(BLOC-1 complex)|GO:0005768(endosome) complex portal:CPX-1153(complex-primary) Endosomal Rab-GAP (GTPase-activating protein) adapter complex which controls the lifetime of active Rab5/Vps21 and thus endosomal maturation along the endocytic pathway. - - - - - - - psi-mi:"MI:0469"(IntAct) P35727(0)|P40003(0)|P48232(0)|P53158(0)|Q06071(0)|Q06333(0) +CPX-1155 CoQ biosynthetic complex Q-synthome|Coenzyme Q synthesis complex 559292 CHEBI:24875(2)|CHEBI:57692(0)|O13525(0)|P27680(0)|P41735(1)|P49017(0)|P53318(0)|Q05779(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0061543(3-demethylubiquinone-6 3-O-methyltransferase activity)|GO:0016712(oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen)|GO:0043334(2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity)|GO:0005743(mitochondrial inner membrane)|GO:0006744(ubiquinone biosynthetic process)|GO:0004395(hexaprenyldihydroxybenzoate methyltransferase activity)|GO:0016709(oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen) intenz:1.14.13.-(identity)|intenz:2.1.1.64(identity)|intenz:2.1.1.114(identity)|intenz:2.1.1.201(identity)|pubmed:24470391(see-also)|complex portal:CPX-1155(complex-primary)|pubmed:28927698(see-also) Required for the synthesis of Coenzyme Q (CoQ), an isoprenylated benzoquinone which functions as an electron carrier from complex I or II to complex III in the inner mitochondrial membrane and which also acts as an antioxidant preventing the oxidation of lipoproteins and the plasma membrane. Assembly of the complex appears to be triggered by 4-hydroxyl-3-hexaprenyl benzoate (HHB) which is a precursor of CoQ. Complex assembly requires the post-translational modification of COQ proteins. Assembly starts with a nucleation around the HBB bound to a nucleating COQ protein, potentially COQ4. The nucleation step is ended with the assembly of a pre-complex that accumulates a CoQ6 intermediate, the demethoxy quinone (DMQ6). DMQ6 is converted to CoQ6 after the activation of COQ7 by dephosphorylation by PTC7. This event allows for the full assembly of the complex. Molecular weight = 1300kDa. - - - - - - psi-mi:"MI:0469"(IntAct) O13525(0)|P27680(0)|P41735(1)|P49017(0)|P53318(0)|Q05779(0) +CPX-1156 Central kinetochore CTF19 complex - 559292 CPX-1187(0)|P38265(0)|P38907(0)|P39731(0)|P47167(0)|Q06162(0)|Q12262(0)|Q12493(0)|Q12748(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-975414 GO:0000776(kinetochore)|GO:0008608(attachment of spindle microtubules to kinetochore) complex portal:CPX-1156(complex-primary) Present in the central kinetochore, where is appears to play a role in the enhancement of cohesin in the pericentromere. May help to mediate the attachment of the centromere to the mitotic spindle by forming interactions between the microtubule-associated outer kinetochore proteins and the centromere-associated inner kinetochore proteins. The COMA subcomplex proteins (CPX-1187) bind to the inner kinetochore proteins whilst the more peripheral proteins do not. Several of the subunits (IML3, CHL4, CTF19, MCM21, CTF3, MCM16 and MCM22) appear to be non-essential although their absence has a significant role in chromosome segregation in meiosis and more limited effects during mitosis. MTW1 is only present in low levels so may only associate with the complex. - - - - - - - psi-mi:"MI:0469"(IntAct) P38265(0)|P38313(0)|P38907(0)|P39731(0)|P47167(0)|P53298(0)|Q02732(0)|Q06162(0)|Q06675(0)|Q12262(0)|Q12493(0)|Q12748(0) +CPX-1157 CUL8-MMS1-MMS22-ESC4 E3 ubiquitin ligase complex CRL complex|Cullin-RING ligase complex 559292 P38850(0)|P47050(0)|Q06164(0)|Q06211(0)|Q08273(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0061630(ubiquitin protein ligase activity)|GO:0003684(damaged DNA binding)|GO:0035361(Cul8-RING ubiquitin ligase complex)|GO:0006334(nucleosome assembly) intenz:2.3.2(identity)|pubmed:20139071(see-also)|pubmed:21554755(see-also)|complex portal:CPX-1157(complex-primary) Ubiquitin ligase complex required for the ubiquition of acetylated histone H3, thus facilitating nucleosome assembly during replication and promoting replication progression during S-phase. RTT107 may recruit and help load the complex onto a DNA damage site at or near a stalled replication fork. A typical Cullin-RING ligase consists of the RING protein HRT1, a cullin, a linker protein, and a substrate receptor. The globular HRT1 binds the E2 enzyme and appears to stimulate ubiquitin transfer by induction of subtle structural changes. - - - - - - psi-mi:"MI:0469"(IntAct) P38850(0)|P47050(0)|Q06164(0)|Q06211(0)|Q08273(0) +CPX-1162 Fatty-acyl-CoA synthase FAS|Fatty acid synthase complex|holo-[acyl-carrier-protein] synthase complex|acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl- reducing) 559292 P07149(6)|P19097(6) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-1537343 GO:0005835(fatty acid synthase complex)|GO:0004321(fatty-acyl-CoA synthase activity)|GO:0031177(phosphopantetheine binding)|GO:0042759(long-chain fatty acid biosynthetic process)|GO:0042759(long-chain fatty acid biosynthetic process) complex portal:CPX-1162(complex-primary)|intenz:2.3.1.41(identity)|intenz:1.1.1.100(identity)|intenz:2.3.1.38(identity)|intenz:2.3.1.39(identity)|intenz:4.2.1.59(identity)|intenz:1.3.1.9(identity)|intenz:3.1.2.14(identity)|pubmed:16950653(see-also)|intenz:2.3.1.86(identity)|pubmed:1631160(see-also)|wwpdb:2uv8(identity)|wwpdb:2vkz(identity)|wwpdb:3hmj(identity)|wwpdb:2pff(identity) Catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. Consists of a multifunctional enzyme composed of two non-identical alpha and beta subunits which are organized in an alpha6beta6 complex with 6 sites of fatty acid synthesis. The alpha subunit, FAS2, contains domains for acyl carrier protein, 3-oxoacyl-[acyl-carrier-protein] reductase, and 3-oxoacyl-[acyl-carrier-protein] synthase. The beta subunit, FAS 1, contains domains for [acyl-carrier-protein] acetyltransferase and malonyltransferase, S-acyl fatty acid synthase thioesterase, enoyl-[acyl-carrier-protein] reductase, and 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase. M.W. = 2.4 E6 kDa. Stokes radius = 108 A. Electron microscopy suggests that three protomeric units of alpha2beta2 are arranged head-to-tail to form a ring structure. Each of the six fatty acid synthesizing centres are composed of two complementary half-alpha subunits and a beta subunit. The heterododecameric complex is composed of a symmetrical alpha hexamer and two C3-symmetrical trimers. Heterododecamer - - - - - psi-mi:"MI:0469"(IntAct) P07149(6)|P19097(6) +CPX-1165 CUL8-MMS1-MMS22-CTF4 E3 ubiquitin ligase complex Cullin-RING ligase complex|CRL complex 559292 P47050(0)|Q01454(0)|Q06164(0)|Q06211(0)|Q08273(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0035361(Cul8-RING ubiquitin ligase complex)|GO:0061630(ubiquitin protein ligase activity)|GO:0006334(nucleosome assembly) intenz:2.3.2(identity)|pubmed:20139071(see-also)|pubmed:21554755(see-also)|complex portal:CPX-1165(complex-primary) Ubiquitin ligase complex required for the ubiquition of acetylated histone H3, thus facilitating nucleosome assembly during replication and promoting replication progression during S-phase. CTF4 is a component of the replisome, and may retain the CUL8 complex at a stalled replication fork. A typical Cullin-RING ligase consists of the RING protein HRT1, a cullin, a linker protein, and a substrate receptor. The globular HRT1 binds the E2 enzyme and appears to stimulate ubiquitin transfer by induction of subtle structural changes. - - - - - - psi-mi:"MI:0469"(IntAct) P47050(0)|Q01454(0)|Q06164(0)|Q06211(0)|Q08273(0) +CPX-1166 CUL8-MMS1-ESC2 E3 ubiquitin ligase complex CRL complex|Cullin-RING ligase complex 559292 P47050(0)|Q06211(0)|Q06340(0)|Q08273(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0035361(Cul8-RING ubiquitin ligase complex)|GO:0061630(ubiquitin protein ligase activity)|GO:0006342(chromatin silencing) pubmed:20139071(see-also)|intenz:2.3.2(identity)|pubmed:21554755(see-also)|complex portal:CPX-1166(complex-primary) Ubiquitin ligase complex that may play a role in transcriptional silencing at telomeric, rDNA and homothallic mating loci. A typical Cullin-RING ligase consists of the RING protein HRT1, a cullin, a linker protein, and a substrate receptor. The globular HRT1 binds the E2 enzyme and appears to stimulate ubiquitin transfer by induction of subtle structural changes. - - - - - - psi-mi:"MI:0469"(IntAct) P47050(0)|Q06211(0)|Q06340(0)|Q08273(0) +CPX-1167 CUL8-MMS1-ORC5 E3 ubiquitin ligase complex CRL complex|Cullin-RING ligase complex 559292 P47050(0)|P50874(0)|Q06211(0)|Q08273(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0006275(regulation of DNA replication)|GO:0061630(ubiquitin protein ligase activity)|GO:0035361(Cul8-RING ubiquitin ligase complex) intenz:2.3.2(identity)|pubmed:20139071(see-also)|pubmed:21554755(see-also)|complex portal:CPX-1167(complex-primary) A ubiquitin ligase complex that may be involved in regulation of DNA replication origins. A typical Cullin-RING ligase consists of the RING protein HRT1, a cullin, a linker protein, and a substrate receptor. The globular HRT1 binds the E2 enzyme and appears to stimulate ubiquitin transfer by induction of subtle structural changes. - - - - - - psi-mi:"MI:0469"(IntAct) P47050(0)|P50874(0)|Q06211(0)|Q08273(0) +CPX-1178 Cytoplasmic dynein complex - 559292 P36022(2)|P40960(2)|Q02647(2)|Q04949(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0016887(ATPase activity)|GO:0005868(cytoplasmic dynein complex)|GO:0008569(ATP-dependent microtubule motor activity, minus-end-directed)|GO:0000132(establishment of mitotic spindle orientation)|GO:0005524(ATP binding)|GO:0040001(establishment of mitotic spindle localization)|GO:0005737(cytoplasm) pubmed:24064538(see-also)|wwpdb:4ht6(subset)|complex portal:CPX-1178(complex-primary) A microtubule minus end-directed motor complex involved in positioning the mitotic spindle during cell division. Yeast undergoes a closed mitosis, and therefore the nucleus and its mitotic spindle must be positioned across the junction between the mother and bud, termed the bud neck, to provide a set of chromosomes to the daughter cell. Dynein anchors to the bud end and becomes activated, allowing force generation between the microtubule and the cortex. The microtubule is pulled to slide along the cortex, causing the spindle to move into the mother-bud neck .Chemical transitions (ATP binding, ATP hydrolysis and the release of inorganic phosphate (Pi) and ADP) are coupled to structural changes in the motor, whilst conversely, mechanical events (such as microtubule binding) can influence the rate of chemical transitions. The dynein complex consists of a dimer heavy chains and a number of intermediate and light chains. The dynein heavy chain contains an N-terminal dimerization/cargo-binding domain and a C-terminal motor domain consisting of a hexameric array of AAA+ ATPase domains. The extended tail of the heavy chain binds to the intermediate (PAC11), light intermediate (DYN3) and light chain (DYN2) subunits. DYN3 appears to be specifically involved in the transfer of dynein from microtubule ends to cortical binding sites, and released from the complex following this transfer. DYN2/PAC11 binding potentiate dynein heavy chain dimerization and concomitant motor processivity. - - - - - - psi-mi:"MI:0469"(IntAct) P36022(2)|P40960(2)|Q02647(2)|Q04949(0) +CPX-1179 DCS1 decapping scavenger complex DcpS complex|DCS1 homodimer complex 559292 Q06151(2) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-15484526 GO:0050072(m7G(5')pppN diphosphatase activity)|GO:0000340(RNA 7-methylguanosine cap binding)|GO:0000956(nuclear-transcribed mRNA catabolic process)|GO:0048471(perinuclear region of cytoplasm)|GO:0106095(m7G(5')pppN diphosphatase complex) complex portal:CPX-1179(complex-primary)|intenz:3.6.1.59(identity)|wwpdb:5bv3(identity)|pubmed:22985415(see-also) m7G(5-prime)pppN diphosphatase which degrades the 5-prime mRNA cap when the cap is no longer attached to the mRNA body but rather within short capped mRNA fragments that are generated from 3-prime to 5-prime mRNA decay. Releases m7GMP. Mononucleoside diphosphates (m7GDP and m3 2,2,7GDP) are not hydrolyzed by the complex, however mononucleoside triphosphates (m7GTP and m3 2,2,7GTP) are, demonstrating the importance of a triphosphate chain for DCS1 hydrolytic activity. Has a high binding affinity for m7GDP, which inhibits the complex, making this mononucleoside diphosphate a potential regulator of cap-dependent cellular processes. - Homodimer - - - - - psi-mi:"MI:0469"(IntAct) Q06151(2) +CPX-1185 DCS1-DCS2 regulator of decapping scavenger complex - 559292 Q06151(1)|Q12123(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-15484518 GO:1903398(regulation of m7G(5')pppN diphosphatase activity)|GO:0000956(nuclear-transcribed mRNA catabolic process)|GO:0000932(P-body) complex portal:CPX-1185(complex-primary) m7G(5-prime)pppN diphosphatase with a kcat/KM value that is significantly lower than that of the Decapping scavenger complex, DCS1 (CPX-1179) and has almost lost the preference for m7GpppG as a substrate shown by the homodimer. Degrades the 5-prime mRNA cap, releasing m7GMP, when the cap is no longer attached to the mRNA body but rather within short capped mRNA fragments that are generated from 3-prime to 5-prime mRNA decay. DCS2 is only expressed by the cell under conditions of diauxic stress, and the formation of this complex may allow the cell to change the distribution and relative activities of the mRNA decay pathways in the stationary phase cell. - Heterodimer - - - - - psi-mi:"MI:0469"(IntAct) Q06151(1)|Q12123(1) +CPX-1186 Nuclear MIS12/MIND complex MIND complex|Mtw1p including Nnf1p-Nsl1p-Dsn1p complex|MTW1 complex 559292 P39731(1)|P40568(1)|P47149(1)|Q12143(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-2911535 GO:0000818(nuclear MIS12/MIND complex)|GO:0008608(attachment of spindle microtubules to kinetochore)|GO:0000922(spindle pole) complex portal:CPX-1186(complex-primary)|pubmed:14633972(see-also)|pubmed:16932742(see-also) A kinetochore complex that assembles independently onto centromeric DNA, required for the spindle checkpoint and kinetochore integrity. MIND plays a role in establishing a bipolar spindle-kinetochore interaction by joining kinetochore subunits contacting DNA to those contacting microtubules. MIND is part of a tridentate linker layer, which also contains the Ndc80 (CPX-548) and COMA (CPX-1187) complexes. Evidence suggests interactions between COMA, MIND, and Ndc80 complexes. MIND is a platform onto which outer kinetochore proteins assemble, including microtubule-binding proteins. It is proposed to have a distinct function with respect to force generation and microtubule attachment. In the absence of MIND, there is bipolar binding without the generation of sufficient pulling force to cause centromere stretching and transient sister-chromatid separation. MIND requires CBF3 complex for assembly onto centromeric DNA. Different combinations of MIND subunits have been found, which may reflect the regulated steps in kinetochore assembly. - Heterotetramer - - - - - psi-mi:"MI:0469"(IntAct) P39731(1)|P40568(1)|P47149(1)|Q12143(1) +CPX-1187 COMA complex Ctf19-Okp1-Mcm21-Ame1 complex 559292 P38313(1)|P53298(1)|Q02732(1)|Q06675(1) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0000817(COMA complex)|GO:0008608(attachment of spindle microtubules to kinetochore) complex portal:CPX-1187(complex-primary)|pubmed:14633972(see-also)|pubmed:16932742(see-also) Heterotetrameric subcomplex of a larger central kinetochore CTF19 complex (CPX-1156). COMA is part of a tridentate linker layer, which also contains the Ndc80 (CPX-548) and MIND (CPX-1186) complexes. Although the COMA, MIND, and Ndc80 complexes assemble independently, evidence suggests subsequent interactions. COMA is a platform onto which outer kinetochore proteins assemble, including microtubule-binding proteins. It is proposed to have a distinct function with respect to force generation and microtubule attachment. In the absence of COMA, there is bipolar binding without the generation of sufficient pulling force to cause centromere stretching and transient sister-chromatid separation. COMA requires CBF3 complex (CPX-1898) for assembly onto centromeric DNA. Different combinations of COMA subunits have been found, which may reflect the regulated steps in kinetochore assembly. - - - - - - - psi-mi:"MI:0469"(IntAct) P38313(1)|P53298(1)|Q02732(1)|Q06675(1) +CPX-1188 DPB11-SLD3-SLD2 DNA replication complex 11–3–2 complex 559292 P34252(0)|P47027(0)|P53135(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0003697(single-stranded DNA binding)|GO:1903466(regulation of initiation of premeiotic DNA replication)|GO:0033314(mitotic DNA replication checkpoint)|GO:0034622(cellular protein-containing complex assembly)|GO:0031261(DNA replication preinitiation complex) pubmed:26710261(see-also)|pubmed:17167417(see-also)|complex portal:CPX-1188(complex-primary)|pubmed:17230184(see-also) Associate with replication origins and promotes loading of DNA polymerases onto the origins to initiate chromosomal DNA replication when cyclin-dependent kinase activity increases at the G1/S cell cycle boundary. May play an active role in assembly or activation of the replication fork CMG helicase (CPX-297) thus playing a role in a critical S phase regulatory mechanism that restricts DNA replication to S phase. Interaction of the complex with with single-stranded DNA may be important for GINS attachment to MCM. DPB11 is believed to be a scaffolding protein that attaches to CDK-phosphorylated SLD2 and SLD3. Each of these proteins, SLD2, SLD3, and DPB11, bind directly to the MCM complex and single-stranded DNA. - - - - - - psi-mi:"MI:0469"(IntAct) P34252(0)|P47027(0)|P53135(0) +CPX-1189 RAD26-DEF1 stalled RNAPII response complex - 559292 P35732(0)|P40352(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-16017566 GO:0061635(regulation of protein complex stability)|GO:2001020(regulation of response to DNA damage stimulus)|GO:0000785(chromatin) complex portal:CPX-1189(complex-primary) Appears to form in response to DNA damage-stalled RNA polymerase II (RNAPII, CPX-2662), when the stall is persistent such as at DNA lesions. RAD26 appears to protect RNAPII from degradation to allow time for repair. When the lesion cannot be rapidly removed by RAD26-promoted DNA repair, DEF1 enables ubiquitination and proteolysis of RNAPII. The complex may therefore act to coordinate a stalling rescue mechanism driven by the two proteins. - - - - - - - psi-mi:"MI:0469"(IntAct) P35732(0)|P40352(0) +CPX-1190 TUL1 E3 ubiquitin ligase complex Dsc E3 ubiquitin ligase complex 559292 P36096(0)|Q08232(0)|Q12015(0)|Q12229(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-16031849 GO:0000139(Golgi membrane)|GO:0044695(Dsc E3 ubiquitin ligase complex)|GO:0061630(ubiquitin protein ligase activity)|GO:0016567(protein ubiquitination)|GO:0006511(ubiquitin-dependent protein catabolic process) intenz:2.3.2.27(identity)|complex portal:CPX-1190(complex-primary) E3 ubiquitin ligase complex required in cells lacking the multivesicular body pathway and under conditions of ubiquitin depletion. Functions in protein homeostasis under non-stress conditions and support a role in protein quality control. N-glycosylated Tul1 binds to the assembled Dsc2-Ubx3-Dsc3 subcomplex. - - - - - - psi-mi:"MI:0469"(IntAct) P36096(0)|Q08232(0)|Q12015(0)|Q12229(0) +CPX-1191 Global genome repair CUL3/RAD7/RAD16/ELC1 ubiquitin ligase complex Global genome repair complex|GGR complex 559292 P06779(0)|P31244(0)|P53202(0)|Q03071(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-8508555 GO:0031463(Cul3-RING ubiquitin ligase complex)|GO:0009411(response to UV)|GO:0004842(ubiquitin-protein transferase activity)|GO:0070911(global genome nucleotide-excision repair)|GO:0006511(ubiquitin-dependent protein catabolic process) intenz:2.3.2(identity)|pubmed:16675952(see-also)|complex portal:CPX-1191(complex-primary) A ubiquitin ligase complex required for optimal nucleotide excision repair following UV-induced DNA damage. Ubiquinates the DNA repair protein RAD4 (P14736), targeting it for degradation by the 26S proteasome following UV radiation. de novo protein synthesis subsequently restores RAD4 to pre-irradiation levels. - - - - - - - psi-mi:"MI:0469"(IntAct) P06779(0)|P31244(0)|P53202(0)|Q03071(0) +CPX-1197 FAR complex STRIPAK-like complex|Far3-7-8-9-10-11 Complex|Factor arrest protein complex 559292 P43592(0)|P46671(0)|P53917(0)|Q03944(0)|Q05040(0)|Q06001(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0005789(endoplasmic reticulum membrane)|GO:0071444(cellular response to pheromone)|GO:0051726(regulation of cell cycle)|GO:0090443(FAR/SIN/STRIPAK complex) complex portal:CPX-1197(complex-primary) Required for pheromone-induced cell cycle arrest and for caspase-10-induced death. Caspase-10 induces the dephosphorylation of the autophagy inducer protein, ATG13, and of RAD53. FAR11 interacts with PP2A (CPX-1856/CPX-1857/CPX-1858/CPX-1859) therefore the FAR complex may target PP2A to regulate ATG13 and RAD53 phosphorylation, and thus induce autophagy and DNA damage-induced arrest. - - - - - - - psi-mi:"MI:0469"(IntAct) P43592(0)|P46671(0)|P53917(0)|Q03944(0)|Q05040(0)|Q06001(0) +CPX-1198 Gamma tubulin small complex gamma-TuRC|gamma-tubulin ring complex|gamma-TUSC|TUB4 complex 559292 CHEBI:15996(2)|P38863(1)|P53378(2)|P53540(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-16079767 GO:0010968(regulation of microtubule nucleation)|GO:0008275(gamma-tubulin small complex)|GO:0005200(structural constituent of cytoskeleton)|GO:0005816(spindle pole body) pubmed:26968363(see-also)|emdb:EMD-2799(identity)|complex portal:CPX-1198(complex-primary) Seeds microtubule nucleation at microtubule-organizing centres, controlling the location and timing of nucleation. Component of the spindle pole body, which is responsible for the nucleation and organisation of microtubules within the cell, thus playing a role in chromosome segregation in mitosis and meiosis and controlling cytoplasmic interphase microtubules. The complex is bound directly to the spindle pole body by SPC110 (P32380) on the nuclear face and SPC72 (P39723) on the cytoplasmic face. Y-shaped, with an elongated body connected to two arms. The body consists of the N-terminal regions of SPC97 and SPC98. The C-terminal regions of SPC97 and SPC98 form the base of each arm of the Y, and TUB4 forms part of a lobe at the end of each arm. Binding of GTP to gamma-tubulin regulates the strength of its interaction with tubulin. The complex then assembles into a single helical turn consisting of 7 gamma-tubulin small complex units, leaving 13 exposed gamma-tubulins, thus allowing 13-protofilament microtubule filaments to template from the complex. The spindle pole body (SPB) consists of a series of stacked layers embedded in the nuclear envelope. The inner plaque is the area where the microtubules dock to the SPB and harbors the gamma-tubulin small complex and the N-terminus of SPC110. The central plaque (CPX-1419) and the Intermediate layer 2 (IL2, CPX-1420) layer are the two core layers. This core is composed of 5 proteins. SPC29 and CMD1 reside in the central plaque. SPC42 is thought to begin within the central plaque, but terminate in the IL2 layer. The C-terminus of SPC110 is in the central plaque where it binds CMD1. The C-terminus of CNM67 lies in the IL2 layer where it binds SPC42 and links the SPB core to the outer plaque. The outer plaque is the cytoplasmic boundary of the SPB where the astral microtubules nucleate from a second region of gamma-tubulin. Heterotetramer - - - - - psi-mi:"MI:0469"(IntAct) P38863(1)|P53378(2)|P53540(1) +CPX-1200 RAP1-GCR1 transcription activation complex GCR complex 559292 P07261(2)|P11938(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-16362956 GO:0005667(transcription regulator complex)|GO:0006110(regulation of glycolytic process)|GO:0060963(positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter)|GO:0043565(sequence-specific DNA binding)|GO:0005634(nucleus) complex portal:CPX-1200(complex-primary) Transcription factor required for the transcription of ribosomal protein and glycolytic genes. Appears to simultaneously bind to two adjacent DNA elements (UAS(RPG) and the CT box, bound specifically by RAP1 and GCR1, respectively). The complex can activate transcription through isolated UAS(RPG) (upstream activating sequence in (ribosomal protein genes)) but not CT elements. - - - - - - The interaction is DNA-independent since it occured despite the presence of ethidium bromide. psi-mi:"MI:0469"(IntAct) P07261(2)|P11938(0) +CPX-1229 RAP1-GCR1-GCR2 transcription activation complex GCR complex|GCR1/2/RAP1 complex 559292 P07261(2)|P11938(0)|Q01722(2) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0005667(transcription regulator complex)|GO:0006110(regulation of glycolytic process)|GO:0060963(positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter)|GO:0043565(sequence-specific DNA binding)|GO:0005634(nucleus) complex portal:CPX-1229(complex-primary) Transcription factor required for the transcription of glycolytic genes. Appears to simultaneously bind to two adjacent DNA elements (UAS(RPG) and the CT box, bound specifically by RAP1 and GCR1, respectively). The complex can activate transcription through isolated UAS(RPG) ((upstream activating sequence in ribosomal protein genes)) but not CT elements. CT box-dependent transcriptional activation requires GCR2. GCR2 is essential only for the expression of CT box-containing glycolytic genes, but not for ribosomal genes, which do not have a CT box. GCR2 tappears to induce a conformation change in GCR1 and/or stimulate its hyperphosphorylation. The leucine zipper regions of GCR1 and GCR2 are required for homodimerization but heterodimerization does not appear to involve these regions. - - - - - The interaction is DNA-independent since it occured despite the presence of ethidium bromide. psi-mi:"MI:0469"(IntAct) P07261(2)|P11938(0)|Q01722(2) +CPX-1230 BNI4-GLC7 phosphatase complex - 559292 CHEBI:29035(2)|P32598(1)|P53858(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-390357 GO:0000164(protein phosphatase type 1 complex)|GO:0032174(cellular bud neck septin collar)|GO:0004722(protein serine/threonine phosphatase activity)|GO:0034221(fungal-type cell wall chitin biosynthetic process) intenz:3.1.3.16(identity)|pubmed:20197406(see-also)|complex portal:CPX-1230(complex-primary) Protein phosphatase complex which is important for the regulation of bud site emergence. The asymmetric localization of BNI4-GLC7 is essential for proper morphological development and correct deposition of the chitin ring as the complex recruits chitin synthase III to the cell cortex on the mother-side of the septin collar. - - - - - - - psi-mi:"MI:0469"(IntAct) P32598(1)|P53858(0) +CPX-1231 GAC1-GLC7 phosphatase complex - 559292 CHEBI:29035(2)|P28006(0)|P32598(1) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0004722(protein serine/threonine phosphatase activity)|GO:0000164(protein phosphatase type 1 complex)|GO:0005979(regulation of glycogen biosynthetic process) intenz:3.1.3.16(identity)|pubmed:11459182(see-also)|complex portal:CPX-1231(complex-primary) Protein phosphatase complex that potentially controls glycogen synthesis by regulating the phosphorylation state of glycogen synthase, GSY2. - - - - - - - psi-mi:"MI:0469"(IntAct) P28006(0)|P32598(1) +CPX-1249 SDS22-GLC7 phosphatase complex - 559292 CHEBI:29035(2)|P32598(1)|P36047(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-16368693 GO:0005634(nucleus)|GO:0004722(protein serine/threonine phosphatase activity)|GO:0000164(protein phosphatase type 1 complex)|GO:0051276(chromosome organization) complex portal:CPX-1249(complex-primary)|intenz:3.1.3.16(identity) Protein phosphatase complex implicated in acting in opposition to the Chromosomal Passenger complex (CPX-1900) at the kinetochore. Glc7 dephosphorylation of kinetochore proteins promotes mitotic spindle attachment. The opposing Chromosomal Passenger complex and Glc7 activities ensure that chromosomes achieve a bipolar attachment to the spindle. SDS22 appears to both act as a targeting subunit for the enzyme and also to regulate phosphatase activity. - - - - - - - psi-mi:"MI:0469"(IntAct) P32598(1)|P36047(1) +CPX-1260 SDS22-GLC7-YPI1 phosphatase complex - 559292 CHEBI:29035(2)|P32598(1)|P36047(0)|P43587(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-16370760 GO:0005634(nucleus)|GO:1905183(negative regulation of protein serine/threonine phosphatase activity)|GO:0000164(protein phosphatase type 1 complex)|GO:0051276(chromosome organization) complex portal:CPX-1260(complex-primary) Protein phosphatase complex implicated in acting in opposition to the Chromosomal Passenger complex (CPX-1900) at the kinetochore. GLC7 dephosphorylation of kinetochore proteins promotes mitotic spindle attachment. The opposing Chromosomal Passenger complex and GLC7 activities ensure that chromosomes achieve a bipolar attachment to the spindle. SDS22 appears to both act as a targeting subunit for the enzyme and also to regulate phosphatase activity. YPI1 may target the complex to the nucleus and also act to maintain the complex in a largely inactive state, preventing inactivation of the spindle checkpoint. - - - - - - - psi-mi:"MI:0469"(IntAct) P32598(1)|P36047(0)|P43587(0) +CPX-1266 REG1-GLC7 phosphatase complex - 559292 CHEBI:29035(2)|P32598(1)|Q00816(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-16372808 GO:0000164(protein phosphatase type 1 complex)|GO:0004722(protein serine/threonine phosphatase activity)|GO:1904547(regulation of cellular response to glucose starvation) intenz:3.1.3.16(identity)|complex portal:CPX-1266(complex-primary) Protein phosphatase complex with a role in glucose repression. REG1-GLC7 binds to SNF1 when the SNF1 kinase complex (CPX-232/CPX-2800/CPX-231) is activated by phosphorylation, which occurs at a much higher rate in glucose-limited cells than in glucose-grown cells. REG1-GLC7 facilitates the transition of the kinase complex back to an autoinhibited state, presumably by dephosphorylating SNF1. - - - - - - - psi-mi:"MI:0469"(IntAct) P32598(1)|Q00816(0) +CPX-1267 REG2-GLC7 phosphatase complex - 559292 CHEBI:29035(2)|P32598(1)|P38232(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-16397985 GO:1904547(regulation of cellular response to glucose starvation)|GO:0000164(protein phosphatase type 1 complex)|GO:0004722(protein serine/threonine phosphatase activity) intenz:3.1.3.16(identity)|complex portal:CPX-1267(complex-primary) Protein phosphatase complex with a role in theresponse to glucose levels. During steady-state growth in high glucose, the SNF1 kinase complex (CPX-232/CPX-2800/CPX-231) is inactive and REG2 is not expressed. Prolonged glucose starvation leads to SNF1-dependent accumulation of REG2. Once glucose becomes abundant, REG2-GLC7 contributes to the rapid dephosphorylation and inactivation of SNF1 which acts as a central regulator of cellular energy homeostasis. - - - - - - - psi-mi:"MI:0469"(IntAct) P32598(1)|P38232(0) +CPX-1268 Glycine decarboxylase multienzyme complex Glycine cleavage complex|GDC complex 559292 CHEBI:57692(1)|P09624(1)|P39726(0)|P48015(0)|P49095(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0006546(glycine catabolic process)|GO:0004047(aminomethyltransferase activity)|GO:0004375(glycine dehydrogenase (decarboxylating) activity)|GO:0005960(glycine cleavage complex)|GO:0004375(glycine dehydrogenase (decarboxylating) activity)|GO:0005739(mitochondrion) pubmed:10871621(see-also)|intenz:2.1.2.10(identity)|intenz:1.4.4.2(identity)|complex portal:CPX-1268(complex-primary)|intenz:1.8.1.4(identity) Catalyzes the oxidative cleavage of glycine into CO2 and NH3, utimately playing a role in the conversion of glycine to serine. The concomitant transfer of a methylene carbon unit to THF1 generates the C1 donor 5,10-methylene tetrahydrofolate. Located in the mitochondrion. The P protein (GCV2, P49095) binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (GV3, P39726). - - - - - - - psi-mi:"MI:0469"(IntAct) P09624(1)|P39726(0)|P48015(0)|P49095(0) +CPX-1269 Glycosylphosphatidylinositol-mannosyltransferase II complex GPI-MT-II complex 559292 P38211(0)|P53896(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-16398124 GO:0120097(glycosylphosphatidylinositol-mannosyltransferase II complex)|GO:0030176(integral component of endoplasmic reticulum membrane)|GO:0000030(mannosyltransferase activity)|GO:0035268(protein mannosylation)|GO:0006506(GPI anchor biosynthetic process)|GO:0031505(fungal-type cell wall organization) pubmed:16859984(see-also)|intenz:2.4.1(identity)|pubmed:23135325(see-also)|complex portal:CPX-1269(complex-primary) Mannosyltransferase complex responsible for the transfer of the second mannose to the glycosylphosphatidylinositol (GPI) during GPI precursor assembly. GPI is a complex glycolipid with a core structure, phosphoethanolamine-6-mannose-alpha1,2-mannose-alpha1,6-mannose-alpha1,4-glucosamine-alpha1,6-inositol-phospholipid that functions as a membrane anchor for many cell surface proteins. - - - - - - - psi-mi:"MI:0469"(IntAct) P38211(0)|P53896(0) +CPX-1270 Glycosylphosphatidylinositol-mannosyltransferase I complex GPI-MT I complex 559292 P25580(0)|P47088(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:1990529(glycosylphosphatidylinositol-mannosyltransferase I complex)|GO:0030176(integral component of endoplasmic reticulum membrane)|GO:0000030(mannosyltransferase activity)|GO:0035268(protein mannosylation)|GO:0006506(GPI anchor biosynthetic process)|GO:0031505(fungal-type cell wall organization) intenz:2.4.1(identity)|pubmed:23135325(see-also)|pubmed:16859984(see-also)|complex portal:CPX-1270(complex-primary) Mannosyltransferase complex responsible for the transfer of the first alpha-1,4-mannose to the glycosylphosphatidylinositol (GPI) during GPI precursor assembly. GPI is a complex glycolipid with a core structure, phosphoethanolamine-6-mannose-alpha1,2-mannose-alpha1,6-mannose-alpha1,4-glucosamine-alpha1,6-inositol-phospholipid that functions as a membrane anchor for many cell surface proteins. - - - - - - - psi-mi:"MI:0469"(IntAct) P25580(0)|P47088(0) +CPX-1274 Glycosylphosphatidylinositol-N-acetylglucosaminyltransferase complex N-Acetyl-Glucosamine-transferase PI-GlcNAc-T complex|GPI-GnT complex|GPI-N-acetylglucosaminyltransferase complex|GPI-GlcNAc transferase complex 559292 P32363(0)|P46961(0)|P53306(0)|P53961(0)|P62651(0)|Q04082(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0017176(phosphatidylinositol N-acetylglucosaminyltransferase activity)|GO:0006506(GPI anchor biosynthetic process)|GO:0030176(integral component of endoplasmic reticulum membrane)|GO:0000506(glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex)|GO:0031505(fungal-type cell wall organization) pubmed:16859984(see-also)|pubmed:23135325(see-also)|intenz:2.4.1.198(identity)|complex portal:CPX-1274(complex-primary)|rhea:RHEA:14789(identity) Monoglycosyltransferase complex that catalyses the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to the 6-position of phosphatidylinositol, the first, and committed, step of glycosylphosphatidylinositol (GPI) biosynthesis. GPI is a complex glycolipid with a core structure, phosphoethanolamine-6-mannose-alpha1,2-mannose-alpha1,6-mannose-alpha1,4-glucosamine-alpha1,6-inositol-phospholipid that functions as a membrane anchor for many cell surface proteins. - - - - - - - psi-mi:"MI:0469"(IntAct) P32363(0)|P46961(0)|P53306(0)|P53961(0)|P62651(0)|Q04082(0) +CPX-1275 GPI-anchor transamidase complex GPIT complex|GPI transamidase complex|Glycosylphosphatidylinositol transamidase complex 559292 P38875(2)|P39012(2)|P41733(2)|P49018(2)|Q04080(2) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0031505(fungal-type cell wall organization)|GO:0003923(GPI-anchor transamidase activity)|GO:0042765(GPI-anchor transamidase complex)|GO:0016255(attachment of GPI anchor to protein)|GO:0030176(integral component of endoplasmic reticulum membrane membrane) pubmed:23135325(see-also)|pubmed:28374821(see-also)|pubmed:16859984(see-also)|intenz:3(identity)|complex portal:CPX-1275(complex-primary) Transamidase enzyme complex that transfers the glycosylphosphatidylinositol (GPI) lipid to the newly made GPI protein in the endoplasmic reticulum, replacing the C-terminal GPI attachment signal peptide of a protein with the lipid. GPI is a complex glycolipid with a core structure, phosphoethanolamine-6-mannose-alpha1,2-mannose-alpha1,6-mannose-alpha1,4-glucosamine-alpha1,6-inositol-phospholipid that functions as a membrane anchor for many cell surface proteins. - - - - - - - psi-mi:"MI:0469"(IntAct) P38875(2)|P39012(2)|P41733(2)|P49018(2)|Q04080(2) +CPX-1276 HMC complex High-molecular-weight complex 559292 P02829(0)|P0CE41(0)|P10591(0)|P10592(0)|P15108(0)|P25491(0)|P25567(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0070482(response to oxygen levels) complex portal:CPX-1276(complex-primary)|pubmed:11689685(see-also) Represses HAP1 activity in the absence of heme, thus modulating oxygen dependent gene expression. The HMC complex is associated with low DNA-binding and transcriptional activities. Heme disrupts the HMC and allows HAP1 to form a dimer, with higher DNA-binding and transcription rate properties. This complex is described as high-molecular weight but this has not actually been measured. Whilst this has been curated a a single large complex, it is possible that smaller variants exist, containing different paralogous proteins. - - - - - - psi-mi:"MI:0469"(IntAct) P02829(0)|P0CE41(0)|P10591(0)|P10592(0)|P15108(0)|P25491(0)|P25567(0) +CPX-1277 INO2-INO4 transcription activation complex - 559292 P13902(0)|P26798(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-2292098 GO:0045944(positive regulation of transcription from RNA polymerase II promoter)|GO:0000977(RNA polymerase II regulatory region sequence-specific DNA binding)|GO:0008654(phospholipid biosynthetic process)|GO:0090575(RNA polymerase II transcription factor complex) pubmed:28827025(see-also)|complex portal:CPX-1277(complex-primary)|pubmed:8195172(see-also)|pubmed:7862526(see-also) Binds to a cis-acting promoter element, designated ICRE (inositol/choline-responsive element, consensus sequence WYTTCAYRTGS). Induces expression of CHO1, the enzyme responsible for the synthesis of phosphatidylethanolamine from CDP-diacylglycerol, under growth conditions when the level of phosphatidate is elevated and tethers the OPI1 repressor to the nuclear/endoplasmic reticulum membrane. - - - - - - - psi-mi:"MI:0469"(IntAct) P13902(0)|P26798(0) +CPX-1278 LMA1 complex, TRX1 variant Low molecular weight activity complex 559292 P0CT04(0)|P22217(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0042144(vacuole fusion, non-autophagic)|GO:0000324(fungal-type vacuole)|GO:0005737(cytoplasm)|GO:0120124(membrane fusion priming complex) complex portal:CPX-1278(complex-primary)|pubmed:12914955(see-also) Required for the trafficking of yeast vacuoles, such as homotypic vacuole and ER-derived COPII vesicle fusion with the Golgi. Acts synergistically with SEC18 to support vacuole fusion and acts in an early stage of the vacuole inheritance reaction. The reduction-oxidation activity of thioredoxin does not appear to be required for this function. - Heteropentamer - - - - - psi-mi:"MI:0469"(IntAct) P0CT04(0)|P22217(0) +CPX-1279 LMA1 complex, TRX2 variant Low molecular weight activity complex 559292 P0CT04(0)|P22803(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0042144(vacuole fusion, non-autophagic)|GO:0000324(fungal-type vacuole)|GO:0005737(cytoplasm)|GO:0120124(membrane fusion priming complex) complex portal:CPX-1279(complex-primary)|pubmed:12914955(see-also) Required for the trafficking of yeast vacuoles, such as homotypic vacuole and ER-derived COPII vesicle fusion with the Golgi. Acts synergistically with SEC18 to support vacuole fusion and acts in an early stage of the vacuole inheritance reaction. The reduction-oxidation activity of thioredoxin does not appear to be required for this function. - Heteropentamer - - - - - psi-mi:"MI:0469"(IntAct) P0CT04(0)|P22803(0) +CPX-1280 Luminal surveillance complex Yos9p/Kar2p/Hrd3p surveillance complex 559292 P16474(0)|Q05787(0)|Q99220(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0034099(luminal surveillance complex)|GO:0030176(integral component of endoplasmic reticulum membrane)|GO:0051082(unfolded protein binding)|GO:0097466(ubiquitin-dependent glycoprotein ERAD pathway)|GO:0002235(detection of unfolded protein) pubmed:16873065(see-also)|pubmed:25086047(see-also)|complex portal:CPX-1280(complex-primary) Recognizes the protein determinant required for ER-associated degradation (ERAD) of mis-folded proteins, recruiting substrates to HRD1-associated machinery, and activating downstream events that commit substrates for degradation. The complex recognizes misfolded glycoproteins independent of their glycosylation status and brings them to the downstream ubiquitination/extraction machinery, however the commitment step to destruction requires the lectin YOS9, which recognizes the glycan species found on terminally misfolded proteins. - - - - - - - psi-mi:"MI:0469"(IntAct) P16474(0)|Q05787(0)|Q99220(0) +CPX-1283 HTM1-PDI1 exomannosidase complex - 559292 CHEBI:29108(0)|P17967(0)|P38888(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-16411837 GO:0004571(mannosyl-oligosaccharide 1,2-alpha-mannosidase activity)|GO:0043394(proteoglycan binding)|GO:1904382(mannose trimming involved in glycoprotein ERAD pathway)|GO:1904380(endoplasmic reticulum mannose trimming)|GO:1900103(positive regulation of endoplasmic reticulum unfolded protein response)|GO:0106055(mannoysl-oligosaccharide 1,2-aplha-mannosidase complex)|GO:0005788(endoplasmic reticulum lumen) intenz:3.2.1.24(identity)|complex portal:CPX-1283(complex-primary) Exomannosidase complex which initiates breakdown of unfolded glycoproteins by trimming the Man8GlcNAc2 glycan to produce Man7GlcNAc2, thus initiating the clearance of these proteins from the endoplasmic reticulum. N-linked Man7GlcNAc2 oligosaccharides serve as a signal for degradation by the Hrd1 ubiquitin ligase complex (CPX-3070). - - - - - - - psi-mi:"MI:0486"(UniProt) P17967(0)|P38888(0) +CPX-1287 MPS2-BBP1 spindle pole body anchor complex MPS2-BBP1 SPB anchor complex 559292 P53159(0)|Q12365(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-3871043 GO:1990608(spindle pole body localization)|GO:0071988(protein localization to spindle pole body)|GO:0016021(integral component of membrane)|GO:0005635(nuclear envelope)|GO:0106084(mitotic nuclear membrane mitotic spindle pole body tethering complex)|GO:0005816(spindle pole body) complex portal:CPX-1287(complex-primary)|pubmed:24112974(see-also) Key mediator of the link between the nuclear envelope and the spindle pole body (SPB), anchoring the SPB to fusion sites of the inner nuclear membrane and outer nuclear membrane. Forms higher molecular weight assemblies with other SPB proteins (MPS3/P47069, SPC29/P33419) which hold the SPB in the nuclear envelope. BBP1 and MPS2 are believed to interact via their coiled-coil regions. - - - - - - psi-mi:"MI:0469"(IntAct) P53159(0)|Q12365(0) +CPX-1288 MEI5-SAE3 DMC1 recombinase assembly factor complex - 559292 P32489(0)|P89114(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-16412524 GO:0007131(reciprocal meiotic recombination)|GO:0000228(nuclear chromosome)|GO:0000707(meiotic DNA recombinase assembly) pubmed:27329041(see-also)|complex portal:CPX-1288(complex-primary) Assembly factor for the meiosis-specific DMC1 recombinase protein, facilitating the loading of DMC1 onto a Rad51 complex at a recombination hot spot on DNA. The coordinated actions of RAD51 and DMC1 are considered to play a critical role in homology searches and strand exchange during recombination. - - - - - - - psi-mi:"MI:0469"(IntAct) P32489(0)|P89114(0) +CPX-1292 REC102-REC104 meiotic recombination initiation complex - 559292 P33323(0)|Q02721(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-16413013 GO:0000794(condensed nuclear chromosome)|GO:0042138(meiotic DNA double-strand break formation) pubmed:25324213(see-also)|complex portal:CPX-1292(complex-primary) Required for the formation and repair of programmed DNA double-strand breaks (DSBs) catalyzed by SPO11 (Q22236) during meiotic recombination. May act to bridge the MER2-MEI4-REC114 complex (CPX-1809) with SPO11 and SKI8 (Q02793). Required for SPO11 nuclear localization, chromatin association, and binding to hot spots. Preferentially localizes to sites on the structural axis, where the series of loops (10-20kb) that pairs of sister chromatids organise into are anchored. - - - - - - - psi-mi:"MI:0469"(IntAct) P33323(0)|Q02721(0) +CPX-1293 Mitochondrial 2-oxoglutarate dehydrogenase complex Mitochondrial alpha-ketoacid dehydrogenase complex 559292 CHEBI:57692(1)|CHEBI:58937(0)|CHEBI:83088(0)|P09624(1)|P19262(0)|P19955(0)|P20967(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-16416419 GO:0005947(mitochondrial alpha-ketoglutarate dehydrogenase complex)|GO:0042645(mitochondrial nucleoid)|GO:0004591(oxoglutarate dehydrogenase (succinyl-transferring) activity)|GO:0006103(2-oxoglutarate metabolic process)|GO:0005739(mitochondrion) intenz:2.3.1.61(identity)|intenz:1.2.4.2(identity)|intenz:1.8.1.4(identity)|complex portal:CPX-1293(complex-primary) Catalyzes the oxidative decarboxylation of alpha-ketoglutarate to succinyl-CoA, NADH and CO2. Succinyl-CoA is then converted to succinate by succinyl-CoA synthetase or used as a substrate in heme biosynthesis. Acts as a major site of reactive oxygen species generation. The KGD2 E2 subunits assemble into a homo-oligomeric core. The E1 subunit is believed to be attracted to this E2 particle to form the E1-E2 core of the enzyme. YMR31 then binds to this E1-E2 core, most likely to the E1 subunit, to recruit the E3 subunit into the complex. - - - - - - psi-mi:"MI:0469"(IntAct) P09624(1)|P19262(0)|P19955(0)|P20967(0) +CPX-1294 Mitochondrial ribonuclease P complex - 559292 Q02773(0)|URS00007E9EB6_559292(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-16416945 GO:0001682(tRNA 5'-leader removal)|GO:0030678(mitochondrial ribonuclease P complex)|GO:0004526(ribonuclease P activity)|GO:0000049(tRNA binding)|GO:0005739(mitochondrion) pubmed:27187488(see-also)|complex portal:CPX-1294(complex-primary) Responsible for the 5' endonucleolytic cleavage of precursor tRNAs (pre-tRNAs) to remove approximately 12 leader nucleotides to yield mature tRNAs. The RNA subunit of the mitochondrial RNase P is most probably a catalytically active ribozyme that is capable of both recognizing and cleaving substrates efficiently and accurately. The protein component serves as an absolutely required cofactor. - - - - - - - psi-mi:"MI:0469"(IntAct) Q02773(0) +CPX-1295 MKT1-PBP1 translation regulation complex - 559292 P40850(0)|P53297(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-16417041 GO:0005844(polysome)|GO:0006417(regulation of translation)|GO:0031494(regulation of mating type switching)|GO:0004519(endonuclease activity) complex portal:CPX-1295(complex-primary) Translational regulation complex which modulates levels of the HO endonucease in the mother cells of budding yeast, enabling the cells to switch mating types. The mechanism is unclear but the nuclease activity activity of MKT1 appears to be equired for the function. - - - - - - - psi-mi:"MI:0469"(IntAct) P40850(0)|P53297(0) +CPX-1302 OPY2-MSB2 osmosensory complex - 559292 P32334(0)|Q06810(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-16417205 GO:0005034(osmosensor activity)|GO:0007232(osmosensory signaling pathway via Sho1 osmosensor)|GO:0005887(integral component of plasma membrane) complex portal:CPX-1302(complex-primary) Osmosensor that activates the HOG1 mitogen-activated protein kinase (P32485), which regulates diverse osmoadaptive responses. Increased external osmolarity induces conformational changes in the complex formed between the Hkr1-Msb2 homology (HMH) domain of MSB2 and the cysteine-rich region of OPY2. This conformational change is transmitted across the plasma membrane to induce an interaction between the associated STE20 (Q03497) and STE11 (P23561) protein kinases, thus activating a signal cascade which culminates in HOG1 activation. - - - - - - - psi-mi:"MI:0469"(IntAct) P32334(0)|Q06810(0) +CPX-1303 MST27-MST28 vesicle formation complex MST27/MST28 complex 559292 P39552(0)|P53176(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-7749126 GO:0030663(COPI-coated vesicle membrane)|GO:0016050(vesicle organization)|GO:0005783(endoplasmic reticulum)|GO:0016021(integral component of membrane)|GO:0005794(Golgi apparatus) pubmed:12925749(see-also)|pubmed:27903609(see-also)|complex portal:CPX-1303(complex-primary) Role in promoting vesicle formation. Appears to provide nucleation sites, which recruit and locally concentrate cytosolic coat complexes onto the membranes of the early secretory pathway. The complexes cycles between the endoplasmic reticulum (ER) and Golgi apparatus, however, its steady-state localization is probably in the ER. - - - - - - - psi-mi:"MI:0469"(IntAct) P39552(0)|P53176(0) +CPX-1304 MYO2-VAC17-VAC8 transport complex - 559292 P19524(0)|P25591(0)|P39968(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-16419054 GO:0071563(Myo2p-Vac17p-Vac8p transport complex)|GO:0000011(vacuole inheritance)|GO:0043495(protein membrane anchor)|GO:0000329(fungal-type vacuole membrane) pubmed:12594460(see-also)|complex portal:CPX-1304(complex-primary) Transport complex required to move the attached vacuole membrane along actin cables from a mother cell into the bud. Once in the bud, VAC17 is degraded, releasing the vacuole from MYO2 and depositing it at the centre of the bud. - - - - - - - psi-mi:"MI:0486"(UniProt) P19524(0)|P25591(0)|P39968(0) +CPX-1306 Nascent polypeptide-associated complex, EGD1-EGD2 variant NAC 559292 P38879(1)|Q02642(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-2272441 GO:0051083('de novo' cotranslational protein folding)|GO:0051082(unfolded protein binding)|GO:0005854(nascent polypeptide-associated complex)|GO:0005737(cytoplasm) pubmed:26618777(see-also)|complex portal:CPX-1306(complex-primary)|pubmed:10219998(see-also) Reversibly binds to cytoplasmic ribosomes and interacts with nascent polypeptides emerging from the ribosome to prevent them from incorrect interactions, thus controlling the early protein folding processes and preventing aggregation or degradation of newly synthesized proteins. The EGD1-EGD2 variant appears to be the dominant form of the complex formed in vivo and has a preference for ribosomes translating metabolic enzymes as well as secretory and membrane proteins. By binding to the first 30-50 amino acids to be translated, the complex prevents mitochondrial precursor proteins synthesized in the cytosol from forming a basic, amphipathic helix. This enables this targeting sequence to first bind to chaperones and mitochondrial import stimulating factors and then to the outer membrane translocase complex (CPX-474) on the mitochondrial surface. - - - - - - - psi-mi:"MI:0469"(IntAct) P38879(1)|Q02642(1) +CPX-1307 Nascent polypeptide-associated complex, BTT1-EGD2 variant NAC 559292 P38879(1)|P40314(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-16295351 GO:0051083('de novo' cotranslational protein folding)|GO:0051082(unfolded protein binding)|GO:0005854(nascent polypeptide-associated complex) pubmed:26618777(see-also)|complex portal:CPX-1307(complex-primary)|pubmed:10219998(see-also) Reversibly binds to cytoplasmic ribosomes and interacts with nascent polypeptides emerging from the ribosome to prevent them from incorrect interactions, thus controlling the early protein folding processes and preventing aggregation or degradation of newly synthesized proteins. The BTT1-EGD2 variant appears to be the less dominant form of the complex formed in vivo and has a preference for ribosomes translating mitochondrial or ribosomal proteins. By binding to the first 30-50 amino acids to be translated, the complex prevents mitochondrial precursor proteins synthesized in the cytosol from forming a basic, amphipathic helix. This enables this targeting sequence to first bind to chaperones and mitochondrial import stimulating factors and then to the outer membrane translocase complex (CPX-474) on the mitochondrial surface. - - - - - - - psi-mi:"MI:0469"(IntAct) P38879(1)|P40314(1) +CPX-1314 bI4 intron splicing factor complex - 559292 EBI-16420196(0)|P03879(0)|P11325(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-16420240 GO:0006397(mRNA processing)|GO:0000372(Group I intron splicing)|GO:0004521(endoribonuclease activity)|GO:0005739(mitochondrion) intenz:3.1(identity)|pubmed:19622748(see-also)|complex portal:CPX-1314(complex-primary)|pubmed:17280737(see-also) Self-splicing ribozymal RNA Group I intron splicing factor for mitochondrial introns. A guanosine cofactor docks onto an active G-binding site and hydrolyses the phosphodiester bond at the splice site located in P1, resulting in a free hydroxyl group at the upstream exon and the guanosine cofactor being attached to the 5-prime end of the intron. Then the terminal guanosine of the intron occupies the G-binding site to organize the second ester-transfer reaction leading to the ligation of the adjacent upstream and downstream exons and release of the catalytic intron. The catalytic core of the complex is formed at the interface of three RNA domains held in a precise and catalytically active three-dimensional architecture by inter-domain tertiary interactions stabilized by protein cofactors. The group I intron RNA core consists of two extended and roughly coaxially stacked helices that form a catalytic cleft, which binds, in turn, the 5′ and 3′ splice site helices and the gguanosine 5′-monophosphate cofactor. NAM2 and BI4 bind to distinct sites on a 380 nucleotide canonical core region of the bI4 intron to form a ternary complex and promote efficient splicing activity. - - - - - - psi-mi:"MI:0469"(IntAct) P03879(0)|P11325(0) +CPX-1315 Nonsense-mediated decay complex Surveillance complex|NMD complex|UPF1-2-3 NMD complex|Upf1p-Nmd2p-Upf3p complex|Upf1-Nmd2-Upf3 complex|nonsense-mediated mRNA decay (NMD) complex|Upf1-Upf2-Upf3 complex|nonsense-mediated mRNA decay complex 559292 P30771(0)|P38798(0)|P48412(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-16420293 GO:0071026(cytoplasmic RNA surveillance)|GO:0070478(nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay)|GO:0003724(RNA helicase activity)|GO:0036002(pre-mRNA binding)|GO:0005524(ATP binding)|GO:0005737(cytoplasm) pubmed:25038084(see-also)|intenz:3.6.4(identity)|complex portal:CPX-1315(complex-primary) Recognizes and elicits the rapid degradation of mRNAs that prematurely terminate translation and also regulates the expression of specific genes by degrading natural mRNAs. Nonsence-mediated decay (NMD) is triggered by the messenger ribonucleoprotein (mRNP) context surrounding the translation termination event. NMD targets can be recognized as targets due to the lack of factors bound downstream from the termination codon. A ribosome terminating translation at a termination codon substantially upstream from the poly(A) tail terminates translation inefficiently. NMD may occur because the PAB1 (P04147) or other factor bound to the poly(A) tail is not in close enough proximity to the terminating ribosome to enable interaction of the PAB1 with SUP35 (P05453), which is bound to the terminating ribosome and thus establishes the correct mRNP context for a normal translation termination event. In the absence of correct translation termination, the nonsense-mediated decay complex interacts with the translation release factor ERF1-ERF3 complex (CPX-435), resulting in an aberrant translation termination event and NMD activation. NMD activation leads to the decapping of the mRNA by the decapping complex, DCP1-DCP2 (CPX-1628), followed by 5-prime to 3-prime degradation of the mRNA by the exoribonuclease XRN1 (P22147). - - - - - - - psi-mi:"MI:0469"(IntAct) P30771(0)|P38798(0)|P48412(0) +CPX-1316 NRD1 snoRNA termination complex Nab3-Nrd1-Sen1 complex|NNS complex 559292 P38996(0)|P53617(0)|Q00416(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0033678(5'-3' DNA/RNA helicase activity)|GO:0008094(DNA-dependent ATPase activity)|GO:0008186(RNA-dependent ATPase activity)|GO:0031126(snoRNA 3'-end processing)|GO:0005524(ATP binding)|GO:0035649(Nrd1 complex)|GO:0005634(nucleus) intenz:3.6.4(identity)|pubmed:25650800(see-also)|complex portal:CPX-1316(complex-primary) ATP-dependent 5-prime->3-prime DNA/RNA helicase complex required for transcription termination at genes encoding snRNAs and snoRNAs30 and at cryptic unstable transcripts, which are an important class of transcription units that code for ncRNA. May also include some mRNAs as substrates. NRD1 and NAB3 recognize and bind to specific motifs on the nascent RNA (GUAA/G and UCUUG respectively) NRD1 additionally interacts with phosphoryated Ser-5 of the C-terminal domain of the largest subunit of RNAPII (CPX-2662). This positions SEN1 onto the nascent RNA in close proximity to RNAPII and the complex translocates along the RNA causing dismantling of the elongation complex (ternary complexes composed of the transcribing RNA polymerase, the DNA template and the nascent RNA) in a reaction that requires the action of the helicase domain of SEN1. - - - - - - - psi-mi:"MI:0469"(IntAct) P38996(0)|P53617(0)|Q00416(0) +CPX-1317 WHI2-PSR1 phosphatase complex - 559292 P12611(0)|Q07800(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-977246 GO:0004721(phosphoprotein phosphatase activity)|GO:1903293(phosphatase complex) intenz:3.1.3(identity)|complex portal:CPX-1317(complex-primary) Protein phosphatase complex required for full activation of the general stress response, possibly through the dephosphorylation of MSN2 (P33748). MSN2 is a transcription factor which binds to cis-acting STREs (stress response elements) in the promoter regions of many stress-responsive genes, and activates their transcription. - - - - - - - psi-mi:"MI:0469"(IntAct) P12611(0)|Q07800(0) +CPX-1318 WHI2-PSR2 phosphatase complex - 559292 P12611(0)|Q07949(0) ECO:0005546(biological system reconstruction evidence based on paralogy evidence used in manual assertion) - GO:0004721(phosphoprotein phosphatase activity)|GO:1903293(phosphatase complex) complex portal:CPX-1317(inferred-from)|complex portal:CPX-1318(complex-primary)|intenz:3.1.3(identity) Protein phosphatase complex required for full activation of the general stress response, possibly through the dephosphorylation of MSN2 (P33748). MSN2 is a transcription factor which binds to cis-acting STREs (stress response elements) in the promoter regions of many stress-responsive genes, and activate their transcription. - - - - - - - psi-mi:"MI:0469"(IntAct) P12611(0)|Q07949(0) +CPX-1319 PSTB lipid transfer acceptor membrane complex - 559292 P53037(0)|P53844(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-12425087 GO:0005543(phospholipid binding)|GO:0120010(intermembrane phospholipid transfer)|GO:0120014(intermembrane phospholipid transfer activity)|GO:0010008(endosome membrane) pubmed:24366873(see-also)|complex portal:CPX-1319(complex-primary) Lipid transfer complex that is responsible for interorganelle transport of phospholipids, specifically for the non-vesicular transport of phospholipids such as phosphatidylserine from the endoplasmic reticulum to the endosome. Resides in the acceptor (endosomal) membrane and binds to specific lipids on the donor membrane. - - - - - - - psi-mi:"MI:0469"(IntAct) P53037(0)|P53844(0) +CPX-1320 Peptide:N-glycanase-Rad23 complex PNG1-RAD23 complex 559292 CHEBI:29105(1)|P32628(1)|Q02890(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-16421956 GO:0000224(peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity)|GO:0035977(protein deglycosylation involved in glycoprotein catabolic process)|GO:0097466(ubiquitin-dependent glycoprotein ERAD pathway)|GO:0043130(ubiquitin binding)|GO:0005737(cytoplasm)|GO:0120125(PNGase complex) intenz:3.5.1.52(identity)|complex portal:CPX-1320(complex-primary)|wwpdb:1X3W(identity) Role in the proteasomal degradation of a specific set of ER-associated protein degradation (ERAD) substrates, specifically deglycosylates the denatured form of N-linked glycoproteins in the cytoplasm and assists proteasome-mediated glycoprotein degradation. - Heterodimer - - - - - psi-mi:"MI:0486"(UniProt) P32628(1)|Q02890(1) +CPX-1322 RAD53-ASF1 complex - 559292 P22216(1)|P32447(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-1370205 GO:0006282(regulation of DNA repair)|GO:2000002(negative regulation of DNA damage checkpoint)|GO:0005634(nucleus) wwpdb:2YGV(identity)|complex portal:CPX-1322(complex-primary)|pubmed:27222517(see-also) Role in recovery from the DNA damage checkpoint. ASF1 binds most of the free and unmodified RAD53 in the cell and this is required for complete dephosphorylation of Rad53 when the upstream DNA damage checkpoint signaling is turned off. Phosphorylation of RAD53 following DNA damage causes dissociation and frees RAD53 to undergo autophosphorylation and activation and to participate in double-strand break repair. - Heterodimer - - - - - psi-mi:"MI:0469"(IntAct) P22216(1)|P32447(1) +CPX-1323 CDC48-CDC23-UFD2 complex - 559292 P25694(0)|P32628(0)|P54860(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-15938317 GO:0070628(proteasome binding)|GO:0030433(ubiquitin-dependent ERAD pathway) wwpdb:3M62(subset)|pubmed:28069863(see-also)|complex portal:CPX-1323(complex-primary) Role in the escort pathway of proteasomal protein degradation, linking the ubiquitylation of specific substrates directly to their delivery to the proteasome. Oligo-ubiquitylated substrates are recognized and extracted by CDC48. UFD2 modifies the client proteins with lys-48-linked chains of four to six ubiquitins. RAD23 is recruited to the ternary complex, in which its UBL domain associates with UFD2, and then CDC48 remodels the complex to release the RAD23-ubiquitylated substrate complex which binds to the proteasome and delivers the substrate for degradation. - - - - - - - psi-mi:"MI:0469"(IntAct) P25694(0)|P32628(0)|P54860(0) +CPX-1331 bI3 intron splicing factor complex - 559292 EBI-16423101(1)|P07266(4)|Q9ZZW7(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-16426155 GO:0000372(Group I intron splicing)|GO:0004521(endoribonuclease activity)|GO:0006397(mRNA processing)|GO:0005739(mitochondrion) complex portal:CPX-1331(complex-primary)|pubmed:17280737(see-also) Self-splicing ribozymal RNA Group I intron splicing factor. A guanosine cofactor docks onto an active G-binding site and hydrolyses the phosphodiester bond at the splice site located in P1, resulting in a free hydroxyl group at the upstream exon and the guanosine cofactor being attached to the 5-prime end of the intron. The terminal guanosine of the intron then occupies the G-binding site to organize the second ester-transfer reaction leading to the ligation of the adjacent upstream and downstream exons and release of the catalytic intron. The catalytic core of the complex is formed at the interface of three RNA domains held in a precise and catalytically active three-dimensional architecture by inter-domain tertiary interactions stabilized by protein cofactors. The group I intron RNA core consists of two extended and roughly coaxially stacked helices that form a catalytic cleft, which binds, in turn, the 5-prime and 3-prime splice site helices and the guanosine 5-prime-monophosphate cofactor. The BI3 maturase and MRS1 bind the intron independently and assemble to form an active ribonucleoprotein catalyst of approximately 420 kDa. Heterohexamer - - - - - psi-mi:"MI:0469"(IntAct) P07266(4)|Q9ZZW7(1) +CPX-1332 RAT1-RAI1 RNA polymerase II termination complex - 559292 P53063(0)|Q02792(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-1551805 GO:0005524(atp binding)|GO:0003723(rna binding)|GO:0004534(5'-3' exoribonuclease activity)|GO:0034353(RNA pyrophosphohydrolase activity)|GO:0005634(nucleus)|GO:0110103(RNA polymerase II termination complex)|GO:1904595(positive regulation of termination of RNA polymerase II transcription) intenz:3.6.1(identity)|intenz:3.1.13(identity)|pubmed:25722373(see-also)|complex portal:CPX-1332(complex-primary) 5-prime-3-prime exoribonuclease which promotes RNA polymerase II (RNAPII) termination by degrading RNA from the newly formed 5-prime phosphorylated end. RNAPII becomes catalytically disrupted when an NTP mis-incorporates and is more efficiently terminated by the complex. - - - - - - - psi-mi:"MI:0469"(IntAct) P53063(0)|Q02792(0) +CPX-1333 RTT109-VPS75 histone acetyltransferase complex - 559292 P53853(2)|Q07794(2) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-15906767 GO:0000785(chromatin)|GO:0043966(histone H3 acetylation)|GO:0070775(H3 histone acetyltransferase complex)|GO:0010484(H3 histone acetyltransferase activity) intenz:2.3.1.48(identity)|wwpdb:3q35(identity)|complex portal:CPX-1333(complex-primary) Histone acetyltransferase complex that acetylates lysines-9, -27 and possibly -56 on newly synthesized histone H3 during S-phase to mediate nucleosome assembly during DNA replication and DNA repair. Complex formation is required for full activity with VPS75, ensuring that RTT109 is efficiently localized in the nucleus, and presenting histones to RTT109 for acetylation. VPS75 forms an obligate homodimer containing an elongated antiparallel helical dimerization domain with globular domains at each end. This is bound on opposite ends by two globular RTT109 molecules to form a symmetrical ring with a hole of approximately 12A diameter. The two RTT109 subunits make extensive sequence-specific contacts with the VPS75 dimer whilst making non-specific interactions with each other. Heterotetramer - - - - - psi-mi:"MI:0469"(IntAct) P53853(2)|Q07794(2) +CPX-1335 RVS161-RVS167 amphiphysin complex Rvs161p-Rvs167p complex 559292 P25343(1)|P39743(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-2607628 GO:0003779(actin binding)|GO:0097320(plasma membrane tubulation)|GO:0030100(regulation of endocytosis)|GO:0030479(actin cortical patch)|GO:0060988(lipid tube assembly)|GO:1990528(Rvs161p-Rvs167p complex) complex portal:CPX-1335(complex-primary) Binds to membranes and promote the membrane curvature required for endocytosis and also potentially membrane scission at the sites of endocytosis. The BAR domains present in both proteins form helical structures at the neck of the invaginating plasma membrane. Functions with INP52 (P50942) to promote scission of the vesicle. The complex appears to protect the PI(4,5)P2 in the vesicle neck resulting in differential hydrolysis by INP52 to generate a lipid phase boundary. This leads to a mechanochemical interfacial force, driving membrane scission. In growing yeast cells, the complexes localize to cortical actin patches, which are sites of endocytosis. Obligate heterodimer. Heterodimer - - - - - psi-mi:"MI:0469"(IntAct) P25343(1)|P39743(1) +CPX-1340 Separase-Securin complex - 559292 P40316(1)|Q03018(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-16427697 GO:0005634(nucleus)|GO:1990520(separase-securin complex)|GO:1902104(positive regulation of metaphase/anaphase transition of meiotic cell cycle) complex portal:CPX-1340(complex-primary)|wwpdb:5U1S(identity)|wwpdb:5U1T(identity) Regulates the metaphase-to-anaphase transition during cell cycle progression, playing a role in control of the metaphase-anaphase transition and anaphase onset. Complex formation both activates and inhibits the protease activity of separase which is responsible for cleaving the MCD1/SCC1 (Q12158) subunit of the cohesin ring that holds sister chromatids together during mitosis. Securin appears to ensure that separase adopts its proper fold required for proteolytic activity and also promotes subcellular localization of separase to the nucleus. Securin is degraded via ubiquitylation by the anaphase-promoting complex (APC, CPX-760, CPX-761, CPX-762, CPX-756) enabling separase to become fully active. Securin binds to both N- and C-terminal regions of separase, and acts as a molecular wedge, disrupting inter-molecular interactions within separase. Heterodimer - - - - - psi-mi:"MI:0469"(IntAct) P40316(1)|Q03018(1) +CPX-1341 SEC23-LST1 COPII cargo recruitment complex - 559292 CHEBI:29105(0)|P15303(0)|P38810(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0006886(intracellular protein transport)|GO:0030127(COPII vesicle coat)|GO:0090110(cargo loading into COPII-coated vesicle) pubmed:25936552(see-also)|pubmed:11086000(see-also)|complex portal:CPX-1341(complex-primary) Adapter complex which interacts with the COPII coat (CPX-2523) to recruit specific cargo proteins, such as PMA1 (P05030), the essential plasma membrane ATPase, into the membrane vesicles that export newly synthesised proteins from the endoplasmic reticulum. Requires the presence of SEC23/SEC24 in the COPII coat for activity. Required for the export of glycosylphosphatidylinositol-anchored proteins to the Golgi apparatus through interaction with the EMP24 complex (CPX-1698). - - - - - - - psi-mi:"MI:0486"(UniProt) P15303(0)|P38810(0) +CPX-1342 SET3C histone deacetylase complex - 559292 CHEBI:15846(0)|CHEBI:29105(1)|P14832(0)|P25357(0)|P36124(0)|P38262(0)|P40480(0)|P53096(0)|P53685(1) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0005634(nucleus)|GO:0034967(Set3 complex)|GO:0017136(NAD-dependent histone deacetylase activity)|GO:0045835(negative regulation of meiotic nuclear division)|GO:0045129(NAD-independent histone deacetylase activity)|GO:0016575(histone deacetylation)|GO:0006974(cellular response to DNA damage stimulus)|GO:0009267(cellular response to starvation) intenz:3.5.1.98(identity)|complex portal:CPX-1342(complex-primary) Histone deacetylase complex important in regulating gene induction during stress response, such as changes in carbon sources, nitrogen starvation and DNA damage. SET3C binds to the histone mark H3K4me2 either in the 5-prime region of the open reading frames or in the promoter regions of some genes, replacing H3K4me3 - - - - - - - psi-mi:"MI:0469"(IntAct) P14832(0)|P25357(0)|P36124(0)|P38262(0)|P40480(0)|P53096(0)|P53685(1) +CPX-1344 SLAC complex SLA1-LAS17 complex 559292 P32790(0)|Q12446(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-975881 GO:0005737(cytoplasm)|GO:0034315(regulation of Arp2/3 complex-mediated actin nucleation)|GO:0140224(SLAC complex) pubmed:22973053(see-also)|complex portal:CPX-1344(complex-primary) Regulates actin polymerization during clathrin-mediated endocytosis. Complex formation inhibits the Arp2/3 nucleation-promoting factor activity of LAS17 and maintains it in an inactive state during the last 20 seconds of the immobile phase of endocytosis. - - - - - - - psi-mi:"MI:0469"(IntAct) P32790(0)|Q12446(0) +CPX-1355 RTT107-SLX4-SLX1 complex SLX1-SLX4-ESC4 complex 559292 P38324(0)|P38850(0)|Q12098(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0005634(nucleus)|GO:2000001(regulation of DNA damage checkpoint) pubmed:16267268(see-also)|complex portal:CPX-1355(complex-primary) Required for checkpoint dampening by reducing RAD53 checkpoint activation. Complex formation enables MEC1 (P38111) and CDK-mediated phosphorylation of SLX4 and RTT107 under replication stress and DNA damage situations. Upon phosphorylation of SLX4 on Ser-486, the complex becomes associated with DPB11 (P47027) and diminishes DPB11 interaction with RAD9, thus reducing RAD53 (P22216) phosphorylation and activation. - - - - - - - psi-mi:"MI:0469"(IntAct) P38324(0)|P38850(0)|Q12098(0) +CPX-1362 SLX4-RAD1-RAD10 endonuclease complex - 559292 P06777(1)|P06838(1)|Q12098(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-16518942 GO:1905348(endonuclease complex)|GO:0004519(endonuclease activity)|GO:0000736(double-strand break repair via single-strand annealing, removal of nonhomologous ends)|GO:0070337(3'-flap-structured DNA binding) pubmed:27172214(see-also)|complex portal:CPX-1362(complex-primary) Endonuclease, which cuts branched DNA structures at the transition between dsDNA and ssDNA. Required for the repair of double-stranded breaks flanked by direct repeat sequences (boxes) which can occur by single-strand annealing), if a 5-prime to 3-prime resection is allowed to progress past the repeats. The complementary single-stranded repeats can anneal, leaving heterologous flaps to be removed by the RAD1–RAD10 endonuclease, before gap-filling and ligation completes the repair thereby deleting one of the repeats and the intervening sequence. SLX4 functions as a scaffold, following phosphorylation by MEC1 (P38111) or TEL1 (P38110), and may participate in proper positioning of RAD1-RAD10 or directing proper assembly/disassembly of one or more tail removal proteins, such as SAW1 (P39735), at 3-prime tailed intermediates. - Heterotrimer - - - - - psi-mi:"MI:0486"(UniProt) P06777(1)|P06838(1)|Q12098(1) +CPX-1363 SAW1-RAD1-RAD10 endonuclease complex Rad1/Rad10/Saw1 complex 559292 P06777(0)|P06838(0)|P39735(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-8871166 GO:0004519(endonuclease activity)|GO:1905348(endonuclease complex)|GO:0070337(3'-flap-structured DNA binding)|GO:0000736(double-strand break repair via single-strand annealing, removal of nonhomologous ends)|GO:0005634(nucleus) pubmed:23299942(see-also)|complex portal:CPX-1363(complex-primary)|pubmed:24565838(see-also) Endonuclease, which cuts branched DNA structures at the transition between dsDNA and ssDNA. Required for the repair of double-stranded breaks flanked by direct repeat sequences (boxes) which can occur by single-strand annealing, if a 5-prime to 3-prime resection is allowed to progress past the repeats. The complementary single-stranded repeats can anneal, leaving heterologous flaps to be removed by the RAD1-RAD10 endonuclease catalyzing the 3-prime-non-homologous tail removal of the single-strand annealing recombination intermediates, before gap-filling and ligation completes the repair thereby deleting one of the repeats and the intervening sequence. SAW1 contributes to 3-prime tail removal as a mediator between a 3-prime DNA flap substrate and RAD1-RAD10. - - - - - - - psi-mi:"MI:0469"(IntAct) P06777(0)|P06838(0)|P39735(0) +CPX-1364 SMC5-SMC6 SUMO ligase complex Resolvin complex 559292 P38632(0)|P40026(0)|P43124(0)|Q03718(0)|Q05541(0)|Q07913(0)|Q08204(0)|Q12749(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-853311 GO:0030915(Smc5-Smc6 complex)|GO:0019789(SUMO transferase activity)|GO:0016925(protein sumoylation)|GO:0000724(double-strand break repair via homologous recombination)|GO:0000781(chromosome, telomeric region)|GO:0032204(regulation of telomere maintenance) intenz:6.3.2(identity)|complex portal:CPX-1364(complex-primary) SUMO ligase complex with a role in homologous recombination (HR) and replication. Required for chromosome segregation at repetitive sequences. Localizes to repetitive elements such as the rDNA and telomeres where is is thought to promote and resolve HR-dependent intermediates. Also required for telomere maintenance during replication and telomere elongation and for SUMOylating components of the replisome, such as MCM2 (P29469) and the POL2 (P21951) subunit of the DNA polymerase epsilon complex (CPX-2110), which is important for replication fork progression in the presence of DNA-damaging agents. NSE1 and NSE3 bind to NSE4 to form a heterotrimer, which in turn interacts with the ATPase head domain generated by the N- and C-termini of SMC5 and SMC6. NSE3 is a MAGE (melanoma-associated antigen gene) domain containing protein that is important for loading the complex onto chromatin - - - - - - psi-mi:"MI:0469"(IntAct) P38632(0)|P40026(0)|P43124(0)|Q03718(0)|Q05541(0)|Q07913(0)|Q08204(0)|Q12749(0) +CPX-1370 SNO1-SNZ1 pyridoxal 5'-phosphate synthase complex - 559292 Q03144(0)|Q03148(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-16519426 GO:0006543(glutamine catabolic process)|GO:1903600(glutaminase complex)|GO:0036381(pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity)|GO:0042823(pyridoxal phosphate biosynthetic process) complex portal:CPX-1370(complex-primary)|intenz:3.5.1.2(identity)|intenz:4.3.3.6(identity) Catalyzes the hydrolysis of glutamine to glutamate and ammonia, thus supplying ammonia as a source of the ring nitrogen of pyridoxine as part of the biosynthesis of pyridoxal 5'-phosphate. SNZ1 may act as a synthetase that mediates the coupling of ammonia with an unknown acceptor substrate, possibly via a tunnel in the synthetase subunit. - - - - - - - psi-mi:"MI:0469"(IntAct) Q03144(0)|Q03148(0) +CPX-1371 SNO2-SNZ1 pyridoxal 5'-phosphate synthase complex SNO2-SNZ1 glutaminase complex 559292 P53823(0)|Q03148(0) ECO:0005546(biological system reconstruction evidence based on paralogy evidence used in manual assertion) - GO:0042823(pyridoxal phosphate biosynthetic process)|GO:0036381(pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity)|GO:0006543(glutamine catabolic process)|GO:1903600(glutaminase complex) complex portal:CPX-1370(inferred-from)|complex portal:CPX-1371(complex-primary)|intenz:3.5.1.2(identity) Catalyzes the hydrolysis of glutamine to glutamate and ammonia, thus supplying ammonia as a source of the ring nitrogen of pyridoxine as part of the biosynthesis of pyridoxal 5'-phosphate. SNZ1 may act as a synthetase that mediates the coupling of ammonia with an unknown acceptor substrate, possibly via a tunnel in the synthetase subunit. - - - - - - - psi-mi:"MI:0469"(IntAct) P53823(0)|Q03148(0) +CPX-1372 SNT2C histone deacetylase complex Rpd3-micro complex 559292 P32561(0)|P53127(0)|Q03214(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-16583974 GO:0004407(histone deacetylase activity)|GO:0006355(regulation of transcription, DNA-templated)|GO:0006979(response to oxidative stress)|GO:0070211(Snt2C complex)|GO:0005634(nucleus) pubmed:23938299(see-also)|intenz:3.5.1.98(identity)|complex portal:CPX-1372(complex-primary) Histone deacetylase complex which may play a role in transcriptional regulation in response tooxidative stress. - - - - - - - psi-mi:"MI:0469"(IntAct) P32561(0)|P53127(0)|Q03214(0) +CPX-1377 SNX4-ATG20 sorting nexin complex SNX4-SNX42 complex 559292 P47057(0)|Q07528(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-6344753 GO:0010009(cytoplasmic side of endosome membrane)|GO:0006886(intracellular protein transport)|GO:0042147(retrograde transport, endosome to Golgi) complex portal:CPX-1377(complex-primary) Required on a maturing endosome to sort and export distinct cargo proteins. The heterodimers oligomerize and coat the membrane, driving a transition in topology from a flat membrane to a form the tubular endosomal network thus generating transport vesicles for trafficking of retromer cargoes. SNX4-ATG20 functions on the SNC1 (P31109) v-SNARE recycling pathway to transport SNC1 to the Golgi - - - - - - - psi-mi:"MI:0469"(IntAct) P47057(0)|Q07528(0) +CPX-1378 SNX4-SNX41 sorting nexin complex SNX4-SNX42 complex 559292 P47057(0)|Q04053(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-16297792 GO:0010009(cytoplasmic side of endosome membrane)|GO:0006886(intracellular protein transport)|GO:0042147(retrograde transport, endosome to Golgi)|GO:0061912(selective autophagy) complex portal:CPX-1378(complex-primary) Required on a maturing endosome to sort and export distinct cargo proteins. The heterodimers oligomerize and coat the membrane, driving a transition in topology from a flat membrane to a form the tubular endosomal network thus generating transport vesicles for trafficking of retromer cargoes . SNX4-SNX41 mediates retrograde sorting of ATG27(P46989), an integral membrane protein implicated in selective autophagy. - - - - - - - psi-mi:"MI:0469"(IntAct) P47057(0)|Q04053(0) +CPX-1379 Mitochondrial succinyl-CoA synthetase complex Succinyl-CoA synthetase complex|Succinyl-CoA ligase|Succinate-CoA ligase [ADP-forming] complex 559292 CHEBI:18420(0)|P53312(0)|P53598(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0004775(succinate-CoA ligase (ADP-forming) activity)|GO:0006099(tricarboxylic acid cycle)|GO:1901289(succinyl-CoA catabolic process)|GO:0009361(succinate-CoA ligase complex (ADP-forming))|GO:0005739(mitochondrion)|GO:0005524(ATP binding) intenz:6.2.1.5(identity)|complex portal:CPX-1379(complex-primary)|rhea:RHEA:17661(identity) Catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate and ATP. This enzyme functions in the tricarboxylic acid (TCA) cycle LSC1 contains the binding sites for coenzyme A and phosphate. - - - - - - psi-mi:"MI:0469"(IntAct) P53312(0)|P53598(0) +CPX-1380 TAP42-RRD2-PPH21 phosphatase complex - 559292 CHEBI:29035(2)|P23594(1)|Q04372(0)|Q12461(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-15641201 GO:0004722(protein serine/threonine phosphatase activity)|GO:0031929(TOR signaling)|GO:0000159(protein phosphatase type 2A complex) complex portal:CPX-1380(complex-primary)|intenz:3.1.3.16(identity) A serine/threonine protein phosphatase complex that plays a major role in TOR1/2 (P35169/P32600)-mediated signaling and gene expression. Rapamycin causes release of the phosphatase-RRD dimer from TAP42. By similarity, the core enzyme of PP2A comprises a catalytic subunit, the C-subunit (PP2Ac), and a scaffolding protein, the A subunit. The substrate specificity of PP2A as well as its intracellular localization are defined by an array of distinct groups of B-type regulatory subunits that bind to the AC dimeric core to form a variety of heterotrimeric complexes. - - - - - - psi-mi:"MI:0486"(UniProt) P23594(1)|Q04372(0)|Q12461(0) +CPX-1381 NVJ1-VAC8 nucleus-vacuole junction complex nucleus-vacuole junction 559292 P38881(2)|P39968(2) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-16585039 GO:0034727(piecemeal microautophagy of nucleus)|GO:0031309(integral component of nuclear outer membrane)|GO:0006629(lipid metabolic process) wwpdb:5xjg(identity)|complex portal:CPX-1381(complex-primary) Nucleus-vacuole junction complex, a membrane contact site formed between perinuclear and vacuolar membranes. Mediates essential cellular processes such as piecemeal microautophagy of the nucleus (PMN), a selective autophagic recycling process stimulated by carbon or nitrogen starvation through the target of rapamycin signaling pathway. Under these conditions, the region of the nucleus in the vicinity of NVJs invaginates into the vacuolar lumen and forms a bleb-like structure, which is released as a vesicle and eventually degraded by vacuolar hydrolases. NVJs are also involved in lipid metabolism by recruiting the two lipid-modifying enzymes, oxystereol-binding proteins homology OSH1 (P35845) involved in nonvesicular lipid trafficking and the enoyl-CoA reductase TSC13 (Q99190) that mediates the synthesis of very-long-chain fatty acids. Self-association of VAC8 is dependent on the interaction with NVJ1. Dissociation of the flexible N-terminal H1 helix from its 12 armadillo repeats (ARM) that form a right-handed superhelical structure, and binding of NVJ1 might induce the reorganization of helices H2 and H3 of ARM1 to form the four-helix bundle structure at the complex interface. An extended loop of NVJ1 binds in an anti-parallel manner to the inner groove generated by the 12 ARMs of VAC8. Heterotetramer - - - - - psi-mi:"MI:0469"(IntAct) P38881(2)|P39968(2) +CPX-1382 TAP42-RRD2-PPH22 phosphatase complex - 559292 CHEBI:29035(2)|P23595(1)|Q04372(0)|Q12461(0) ECO:0005546(biological system reconstruction evidence based on paralogy evidence used in manual assertion) - GO:0004722(protein serine/threonine phosphatase activity)|GO:0031929(TOR signaling)|GO:0000159(protein phosphatase type 2A complex) complex portal:CPX-1380(inferred-from)|complex portal:CPX-1382(complex-primary)|intenz:3.1.3.16(identity) A serine/threonine protein phosphatase complex that plays a major role in TOR1/2 (P35169/P32600)-mediated signaling and gene expression. Rapamycin causes release of the phosphatase-RRD dimer from TAP42. By similarity, the core enzyme of PP2A comprises a catalytic subunit, the C-subunit (PP2Ac), and a scaffolding protein, the A subunit. The substrate specificity of PP2A as well as its intracellular localization are defined by an array of distinct groups of B-type regulatory subunits that bind to the AC dimeric core to form a variety of heterotrimeric complexes. - - - - - - psi-mi:"MI:0469"(IntAct) P23595(1)|Q04372(0)|Q12461(0) +CPX-1383 TRAPPIII protein complex Transport protein particle III complex 559292 P36149(2)|P38334(1)|P46944(1)|Q03337(1)|Q03630(1)|Q03784(1)|Q99394(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-15847185 GO:1990072(TRAPPIII protein complex)|GO:0000407(pre-autophagosomal structure)|GO:0016236(macroautophagy)|GO:0005085(guanyl-nucleotide exchange factor activity) emdb:5741(identity)|complex portal:CPX-1383(complex-primary) Tethering complexes which provide the initial recognition event that links a particular vesicle with its target membrane. It is an Autophagy-specific guanine nucleotide exchange factor for the Rab GTPase YPT1 (P01123) that is recruited to the phagophore assembly site (PAS) when macroautophagy is induced by the ATG1 kinase complex (CPX-1676). The TRAPPIII-specific subunit, TRS85, targets this complex to the PAS. BET3, BET5, TRS23, and TRS31 create a catalytic site for promoting GDP/GTP exchange in YPT1. TRAPPIII is 23 nm long with TRS85 capping one end of the complex. Heterooctamer - - - - - psi-mi:"MI:0469"(IntAct) P36149(2)|P38334(1)|P46944(1)|Q03337(1)|Q03630(1)|Q03784(1)|Q99394(1) +CPX-1384 SUM1-RFM1-HST1 histone deacetylase complex SUM1 complex 559292 CHEBI:29105(1)|P46676(0)|P53685(1)|Q12192(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0000118(histone deacetylase complex)|GO:0004407(histone deacetylase activity)|GO:0006357(regulation of transcription by RNA polymerase II)|GO:0043937(regulation of sporulation)|GO:0030174(regulation of DNA-dependent DNA replication initiation) intenz:3.5.1(identity)|complex portal:CPX-1384(complex-primary) Histone deacetylase complex which represses the expression of middle sporulation genes during vegetative growth. The histone H3 specific methyltransferase SET1 (P38827) promotes association of the locus-specific SUM1-RFM1-HST1 repressor complex with the middle sporulation element in the promoter region of a subset of genes. Once bound, the complex maintains histone H4 lys-5 in a deacetylated state. The complex is also required for full initiation capacity of ORC-mediated replication initiation at consensus sequence within origins of replication in the genome. - - - - - - - psi-mi:"MI:0469"(IntAct) P46676(0)|P53685(1)|Q12192(0) +CPX-1386 Synapsis initiation complex - 559292 P17122(0)|P40511(0)|P53061(0)|Q06032(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0000794(condensed nuclear chromosome)|GO:0016925(protein sumoylation)|GO:0090173(regulation of synaptonemal complex assembly)|GO:0035825(homologous recombination)|GO:0106069(synapsis initiation complex)|GO:0007129(synapsis)|GO:0019789(SUMO transferase activity) complex portal:CPX-1386(complex-primary) Forms at axial association sites, where the chromosomes are in close contact, and is required for polymerization of ZIP1 (P31111) along the lengths of chromosomes during synapsis, the pairing of two homologous chromosomes that occurs during meiosis. ZIP1 polymerization into oligomeric arrays of transverse filaments leads to the formation of the synaptonemal complex, a proteinaceous connection between homologous chromosomes which forms during meiotic prophase. The accumulation of the ZIP1 appears to require the SUMO E3 ligase activity of CST9. The complex may also promote MSH4-MSH5 complex (CPX-1704)-mediated crossovers, the exchange of genetic material between homologous chromosomes during meiosis. - - - - - - - psi-mi:"MI:0469"(IntAct) P17122(0)|P40511(0)|P53061(0)|Q06032(0) +CPX-1387 Synaptonemal complex - 559292 P14291(0)|P20050(0)|P31111(0)|Q04110(0)|Q06201(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0007129(synapsis)|GO:0000794(condensed nuclear chromosome)|GO:0000795(synaptonemal complex)|GO:0035825(homologous recombination)|GO:0007131(reciprocal meiotic recombination) complex portal:CPX-1387(complex-primary)|pubmed:28357343(see-also)|pubmed:28045371(see-also) Liquid crystalline structure that assembles between homologous chromosomes during meiotic prophase. Required for stabilising chromosome pairing and alignment, and for crossover events and chiasmata formation between homologous chromosome pairs. Mediates the lengthwise alignment of homologous chromsomes within 100 nm of each other witht hread-like axial or lateral elements are paired together by transverse filaments formed by oligomerized ZIP1 proteins. The axial element contains the axis proteins RED1 and HOP1 which appear to require the activity of the meiotic cohesin complex (CPX-1408) for correct assembly. ZIP1 dimers are organized near their N-termini by a complex of proteins including ECM11 and SUMOylated ECM11. ECM11 SUMOylation promotes ZIP1 assembly whilst ZIP1 promotes ECM11 SUMOylation in a positive feedback loop leading to further assembly of ZIP1, loading of ECM11/GMC2 and SUMOylation of ECM11 until the Synaptonemal complex is fully established. Two ZIP1 coiled-coil units (either dimers or tetramers) span the width of the synaptonemal complex, with their N-termini interacting at the center of the structure and their C-termini oriented toward chromosome axes thus forming a 50-80 nm rod with globular ends. - - - - - - psi-mi:"MI:0469"(IntAct) P14291(0)|P20050(0)|P31111(0)|Q04110(0)|Q06201(0) +CPX-1407 ECM11-GMC2 synaptonemal assembly activation factor complex E-G complex 559292 Q04110(0)|Q06201(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-16590522 GO:0007130(synaptonemal complex assembly)|GO:0000794(condensed nuclear chromosome) complex portal:CPX-1407(complex-primary) Facilitates the assembly of the transverse filament of the synaptonemal complex (CPX-1387) by promoting the oligomerisation of ZIP1 (P31111). Recruited to the site of synapsis initiation complex (CPX-1386) binding where it may act to stabilise the nascent ZIP1 oligomer. ECM11 SUMOylation promotes ZIP1 assembly whilst ZIP1 promotes ECM11 SUMOylation in a positive feedback loop leading to further assembly of ZIP1, loading of ECM11-GMC2 and SUMOylation of ECM11 until the Synaptonemal complex is fully established. - - - - - - - psi-mi:"MI:0469"(IntAct) Q04110(0)|Q06201(0) +CPX-1408 Nuclear meiotic cohesin complex Cohesin complex 559292 P32908(0)|P40541(0)|P47037(0)|Q12188(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0003682(chromatin binding)|GO:0034991(nuclear meiotic cohesin complex)|GO:0034089(establishment of meiotic sister chromatid cohesion)|GO:0005634(nucleus) complex portal:CPX-1408(complex-primary)|pubmed:26258962(see-also) Required for sister chromatid cohesion during meiotic cell division, which enables cells to attach sister kinetochores to microtubules with opposing polarity (bi-orientation) and subsequently resists the tendency of these microtubules to pull chromatids toward opposite spindle poles. Before the commencement of replication, the cohesin complex is loaded onto DNA. The arms of the SMC1/3 molecules embrace the DNA, thereby forming a ring of approx. 40 nm diameter. The head domains of SMC1 and SMC3 are locked together by REC8. Cohesion might be generated as the replication fork passes through the ring, entrapping both sister chromatids inside. At the metaphase to anaphase transition, REC8 is cleaved by separase, thereby opening the lock of the SMC1/3 head domains. The ring opens and sister chromatids can be pulled to opposite spindle poles. REC8 is required to efficiently recruit meiotic axis proteins such as RED1 and evenly distribute these along the meiotic chromosomes. SMC1 and SMC3 form a heterodimer with intramolecular coiled coils. REC8 bridges the head domains of SMC1 and SMC3 and links them to SCC3. - - - - - - psi-mi:"MI:0469"(IntAct) P32908(0)|P40541(0)|P47037(0)|Q12188(0) +CPX-1409 UTP-A complex U three protein complex A|t-UTP complex 559292 P38882(0)|P42945(0)|P53276(0)|Q02931(0)|Q04177(0)|Q04305(0)|Q06679(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-16678283 GO:0005730(nucleolus)|GO:0034455(t-UTP complex)|GO:0030490(maturation of SSU-rRNA)|GO:0042134(rRNA primary transcript binding)|GO:0030515(snoRNA binding) complex portal:CPX-1409(complex-primary)|pubmed:27354316(see-also)|pubmed:27980088(see-also) Required for early co-transcriptional events in ribosome biogenesis, acting as an RNA chaperone to initiate ribosome assembly. At the earliest stages of transcription, three subunits of UTPA (UTP8, UTP9 and UTP17) bind to nascent pre-rRNA at the very 5′ end while the remaining four subunits (UTP10, UTP4, UTP5 and UTP15) interact with nucleotides further downstream in the 5-prime-external transcribed spacer (ETS). May also act to stimulate U3 snoRNP recruitment. A sub-unit of the small subunit (SSU) processome, a 2.2 MDa ribonucleoprotein complex involved in the processing, assembly and maturation of nascent pre-ribosomal RNA to form the small ribosomal subunit. The SSU processome is a giant particle composed of numerous ribosome assembly factors, including the UTP-A, UTP-B (CPX-1410), UTP-C (CPX-772/CPX-771/CPX-773) and MPP10 (CPX-1893) complexes, the U3 small nucleolar ribonucleoprotein (snoRNP) and many individual proteins. - - - - - - - psi-mi:"MI:0486"(UniProt) P38882(0)|P42945(0)|P53276(0)|Q02931(0)|Q04177(0)|Q04305(0)|Q06679(0) +CPX-1410 UTP-B complex - 559292 P25635(0)|P40362(0)|Q02354(0)|Q05946(0)|Q06078(0)|Q12220(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-16590891 GO:0005730(nucleolus)|GO:0034388(Pwp2p-containing subcomplex of 90S preribosome)|GO:0030490(maturation of SSU-rRNA)|GO:0042134(rRNA primary transcript binding)|GO:0030515(snoRNA binding) complex portal:CPX-1410(complex-primary)|pubmed:27354316(see-also)|pubmed:27980088(see-also) Required for early co-transcriptional events in ribosome biogenesis, acting as an RNA chaperone to initiate ribosome assembly. May facilitate specific U3 snoRNA- 5-prime-external transcribed spacer (ETS) base-pairing with PWP2 bridging the interaction site. A sub-unit of the small subunit (SSU) processome, a 2.2 MDa ribonucleoprotein complex involved in the processing, assembly and maturation of nascent pre-ribosomal RNA to form the small ribosomal subunit. The SSU processome is a giant particle composed of numerous ribosome assembly factors, including the UTP-A (CPX-1409), UTP-B, UTP-C (CPX-772/CPX-771/CPX-773) and MPP10 (CPX-1893) complexes, the U3 small nucleolar ribonucleoprotein (snoRNP) and many individual proteins. - - - - - - - psi-mi:"MI:0486"(UniProt) P25635(0)|P40362(0)|Q02354(0)|Q05946(0)|Q06078(0)|Q12220(0) +CPX-1412 UBP3-BRE5 ubiquitin hydrolase complex Bre5/Ubp3 ubiquitin protease complex|Ubp3-Bre5 deubiquitination complex 559292 P53741(2)|Q01477(2) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-16591601 GO:0034063(stress granule assembly)|GO:0034517(ribophagy)|GO:1901525(negative regulation of mitophagy)|GO:0005829(cytosol)|GO:0005739(mitochondrion)|GO:0019783(ubiquitin-like protein-specific protease activity)|GO:0060628(regulation of ER to Golgi vesicle-mediated transport)|GO:2000156(regulation of retrograde vesicle-mediated transport, Golgi to ER)|GO:1990861(Ubp3-Bre5 deubiquitination complex) complex portal:CPX-1412(complex-primary)|wwpdb:2QIY(identity)|intenz:3.4.19.12(identity) Specifically deubiquitylates and consequently controls the expression level of the SEC23 (P15303) and SEC27 (P41811) subunits of the COPII (CPX-2523) and COPI complexes that regulate anterograde and retrograde transport between the endoplasmic reticulum and the Golgi apparatus respectively. Also required for the assmbly of nonmembranous ribonucleoprotein stress granules. Inhibits mitophagy but promotes other types of autophagy, including ribophagy. The complex translocates dynamically from the cytosol to the mitochondria upon induction of mitophagy. The UBP3 N-terminal domain adopts a novel L-shaped beta-sheet-turn-alpha-helix topology that interacts with the BRE5 NTF2-like domain (IPR018222). Heterotetramer - - - - - psi-mi:"MI:0486"(UniProt) P53741(2)|Q01477(2) +CPX-1413 VPS55-VPS68 sorting complex - 559292 P47111(0)|Q12016(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-16592009 GO:0032511(late endosome to vacuole transport via multivesicular body sorting pathway)|GO:0034424(Vps55/Vps68 complex) complex portal:CPX-1413(complex-primary) Appears to act with or downstream of the ESCRT (Endosomal sorting complex required for transport) machinery to regulate trafficking at endosome and may also mediate a step in the endosomal maturation process. - - - - - - - psi-mi:"MI:0469"(IntAct) P47111(0)|Q12016(0) +CPX-1414 UBA3-ULA1 E1 enzyme - 559292 Q12059(0)|Q99344(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-803524 GO:0019781(NEDD8 activating enzyme activity)|GO:0045116(protein neddylation)|GO:0005524(ATP binding)|GO:0120123(ubiquitin activating enzyme complex) complex portal:CPX-1414(complex-primary)|intenz:6.3.2(identity) E1 enzyme complex that activates the Ubiquitin-like protein modifier RUB1 (Q03919) by adenylating its C-terminal glycine residue using ATP, then linking this residue to the side chain of the catalytic cysteine of UBA3 (Cys-168), yielding NEDD8-UBA3. This is conjugated by the E2 UBC12 (P52491) to a single site in the carboxyl termini of cullins, a family of hydrophobic proteins providing a scaffold for E3 ubiquitin ligases, thus modulating the E3 enzymatic activity. - - - - - - - psi-mi:"MI:0469"(IntAct) Q12059(0)|Q99344(0) +CPX-1415 IME1-UME6 transcription activation complex - 559292 P21190(0)|P39001(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-16629689 GO:0010673(positive regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle)|GO:0003700(DNA binding transcription factor activity)|GO:0042173(regulation of sporulation resulting in formation of a cellular spore)|GO:0005667(transcription regulator complex)|GO:0005634(nucleus) complex portal:CPX-1415(complex-primary) Transcriptional activator that acts at promoters of early meiosis-specific genes and recruits the histone acetyl transferase Gcn5 to initiate transcription. Formation of the complex under meiotic induction conditions converts the URS1 element-binding protein, UME6, from a repressor to an activator resulting in the formation of asci. Phosphorylation of IME1 by RIM11 (P38615) is required for complex formation. - - - - - - - psi-mi:"MI:0469"(IntAct) P21190(0)|P39001(0) +CPX-1417 BBP-MUD2 branchpoint-binding complex MSL5-MUD2 branchpoint-binding complex|Mud2-Msl5-BP complex 559292 P36084(1)|Q12186(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-971077 GO:0045131(pre-mRNA branch point binding)|GO:0000398(mRNA splicing, via spliceosome)|GO:0000245(spliceosomal complex assembly)|GO:0005634(nucleus) complex portal:CPX-1417(complex-primary) Orchestrates spliceosome assembly by binding the intron branchpoint sequence 5-prime-UACUAAC and establishes cross intron-bridging interactions with the U1 snRNP (CPX-23) at the 5-prime splice site of an unspliced intron in an RNA transcript. - Heterodimer - - - - - psi-mi:"MI:0469"(IntAct) P36084(1)|Q12186(1) +CPX-1418 Spliceosomal commitment complex CC 559292 CPX-1417(0)|CPX-23(0)|EBI-16716764(0)|P21372(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0000243(commitment complex)|GO:0030627(pre-mRNA 5'-splice site binding)|GO:0005634(nucleus)|GO:0000398(mRNA splicing, via spliceosome) complex portal:CPX-1418(complex-primary)|pubmed:22762203(see-also) Formation of this complex is the first defined step in the yeast splicing pathway and is responsible for intron recognition, which targets pre-mRNA to the splicing pathway. Binding of the 5-prime end of U1 snRNP (CPX-23) to the 5-prime splice site through base-pairing forms first a basal complex only dependent on a 5-prime splice site (CC1) and then a more stable second complex dependent on a branchpoint as well as a 5-prime splice site region (CC2). Interactions between the BBP-MUD2 branchpoint-binding complex (CPX-1417) and the U1 snRNP protein PRP40 (P33203) defines a bridge between the two ends of the intron. PRP5 may interact with U1 snRNP and other proteins to bridge the 5' splice site and the UACUAACA box of the pre-mRNA's branchpoint region. It may also recruit U2 snRNP (CPX-26) which binds to the intron branch site of the commitment complex to form the pre-spliceosome in an ATP dependent step. - - - - - - - psi-mi:"MI:0469"(IntAct) P21372(0)|P32605(0)|P33203(0)|P36084(0)|P39682(0)|P40018(0)|P40204(0)|P43321(0)|P53207(0)|P54999(0)|Q00539(0)|Q00916(0)|Q02260(0)|Q03776(0)|Q03782(0)|Q05900(0)|Q06217(0)|Q07508(0)|Q12186(0)|Q12330(0) +CPX-1419 Spindle pole body central plaque complex SPC110 complex 559292 P06787(0)|P32380(0)|P33419(0)|P36094(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0005200(structural constituent of cytoskeleton)|GO:0005823(central plaque of spindle pole body)|GO:0010968(regulation of microtubule nucleation) pubmed:22491889(see-also)|complex portal:CPX-1419(complex-primary) Component of the spindle pole body, which is responsible for the nucleation and organisation of microtubules within the cell, thus playing a role in chromosome segregation in mitosis and meiosis and controlling cytoplasmic interphase microtubules. The spindle pole body (SPB) consists of a series of stacked layers embedded in the nuclear envelope. The inner plaque is the area where the microtubules dock to the SPB and harbors the gamma-tubulin small complex (CPX-1198) and the N-terminus of SPC110. The central plaque and the Intermediate layer 2 (IL2) layer are the two core layers. This core is composed of 5 proteins. SPC29 and CMD1 reside in the central plaque. SPC42 is thought to begin within the central plaque, but terminate in the IL2 layer. The C-terminus of SPC110 is in the central plaque where it binds CMD1. The C-terminus of CNM67 lies in the IL2 layer where it binds SPC42 and links the SPB core to the outer plaque. The outer plaque is the cytoplasmic boundary of the SPB where the astral microtubules nucleate from a second region of gamma-tubulin. - - - - - - psi-mi:"MI:0469"(IntAct) P06787(0)|P32380(0)|P33419(0)|P36094(0) +CPX-1420 Spindle pole body intermediate layer 2 complex - 559292 P36094(0)|P53865(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-1567021 GO:0005200(structural constituent of cytoskeleton)|GO:0005823(central plaque of spindle pole body)|GO:0010968(regulation of microtubule nucleation) pubmed:22491889(see-also)|complex portal:CPX-1420(complex-primary) Component of the spindle pole body, which is responsible for the nucleation and organisation of microtubules within the cell, thus playing a role in chromosome segregation in mitosis and meiosis and controlling cytoplasmic interphase microtubules. The spindle pole body (SPB) consists of a series of stacked layers embedded in the nuclear envelope. The inner plaque is the area where the microtubules dock to the SPB and harbors the gamma-tubulin small complex (CPX-1198) and the N-terminus of SPC110. The central plaque and the Intermediate layer 2 (IL2) layer are the two core layers. This core is composed of 5 proteins. SPC29 and CMD1 reside in the central plaque. SPC42 is thought to begin within the central plaque, but terminate in the IL2 layer. The C-terminus of SPC110 is in the central plaque where it binds CMD1. The C-terminus of CNM67 lies in the IL2 layer where it binds SPC42 and links the SPB core to the outer plaque. The outer plaque is the cytoplasmic boundary of the SPB where the astral microtubules nucleate from a second region of gamma-tubulin. - - - - - - psi-mi:"MI:0469"(IntAct) P36094(0)|P53865(0) +CPX-1421 NOP8 60s ribosome pre-assembly complex 60S ribosomal maturation complex 559292 P34241(0)|P47108(0)|P53734(0)|Q05942(0)|Q08287(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0070180(large ribosomal subunit rRNA binding)|GO:0005634(nucleus)|GO:0042273(ribosomal large subunit biogenesis) complex portal:CPX-1421(complex-primary) May function as a scaffold to mediate topological rearrangements by the RNA helicases and organize assembly of early pre-60S ribosomes. - - - - - - - psi-mi:"MI:0469"(IntAct) P34241(0)|P47108(0)|P53734(0)|Q05942(0)|Q08287(0) +CPX-1422 TEL2-TTI1-TTI2 complex TTT complex|TEL2 complex 559292 P36097(0)|P47168(0)|P53038(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-4567545 GO:0005634(nucleus)|GO:0050821(protein stabilization)|GO:2000003(positive regulation of DNA damage checkpoint)|GO:0110078(TTT complex) complex portal:CPX-1422(complex-primary) Regulates the stability of phosphatidylinositol 3-kinase-related protein kinases (PIKKs) such as TEL1 (P38110) and MEC1 (P38111), which are required for checkpoint signaling. Newly synthesized PIKK interacts with TEL2, in the TEL2-TTI1-TTI2 complex assisted by HSP90 (P02829). Phosphorylated TEL2 then appears to mediate the interaction between PIKK and R2TP complex to eventually lead to the proper assembly of PIKK. - - - - - - - psi-mi:"MI:0469"(IntAct) P36097(0)|P47168(0)|P53038(0) +CPX-1423 COX1 pre-assembly complex COA complex D5 559292 P0CS90(0)|P32335(0)|P39103(0)|Q3E7B2(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0050821(protein stabilization)|GO:0070130(negative regulation of mitochondrial translation)|GO:0033617(mitochondrial respiratory chain complex IV assembly)|GO:0031305(integral component of mitochondrial inner membrane)|GO:0005739(mitochondrion) complex portal:CPX-1423(complex-primary)|pubmed:21068384(see-also) Binds to and stabilizes COX1 (P00401) during the assembly of mitochondrial respiratory chain complex IV/cytochrome C oxidase (CPX-1721/CPX-1722). The process is probably catalyzed by assembly chaperones such as SHY1 (P53266) and COA1 (P40452). The complex also acts to trap the COX1-mRNA-specific translational activator, MSS51, thus rendering it incompetent to support translation of COX1. On further maturation of the assembly intermediate, MSS51 dissociates and can stimulate further rounds of COX1 mRNA translation. - - - - - - - psi-mi:"MI:0469"(IntAct) P0CS90(0)|P32335(0)|P39103(0)|Q3E7B2(0) +CPX-1424 Tubulin alpha-beta heterodimeric complex, TUB1 variant - 559292 CHEBI:15996(2)|P02557(1)|P09733(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-16632257 GO:0005200(structural constituent of cytoskeleton)|GO:0045298(tubulin complex)|GO:0000226(microtubule cytoskeleton organization) emdb:EMD-8755(identity)|emdb:EMD-8756(identity)|emdb:EMD-8757(identity)|pubmed:25957412(see-also)|complex portal:CPX-1424(complex-primary) Building block of the non-covalent cylindrical polymers that make up the hollow water-filled microtubule structures required for the migration and proper orientation of the nucleus, spindle pole body separation, spindle function, and nuclear division. Composed of a compact globular body and unstructured, negatively charged tubulin C-terminal tails. The C-terminal tails are regions of heavy post-translational modification (inclduing phosphorylation, acetylation, palmitoylation, sumoylation, polyamination, S-nitrosylation, glutamylation, glycylation) and serve as interaction sites for molecular motors and other associated proteins and thus can tune the activity of these effectors. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Heterodimer - - - - - psi-mi:"MI:0486"(UniProt) P02557(1)|P09733(1) +CPX-1425 Tubulin alpha-beta heterodimeric complex, TUB3 variant - 559292 CHEBI:15996(2)|P02557(1)|P09734(1) ECO:0005546(biological system reconstruction evidence based on paralogy evidence used in manual assertion) - GO:0005200(structural constituent of cytoskeleton)|GO:0045298(tubulin complex)|GO:0000226(microtubule cytoskeleton organization) complex portal:CPX-1424(inferred-from)|pubmed:25957412(see-also)|complex portal:CPX-1425(complex-primary) Building block of the non-covalent cylindrical polymers that make up the hollow water-filled microtubule structures required for the migration and proper orientation of the nucleus, spindle pole body separation, spindle function, and nuclear division. Composed of a compact globular body and unstructured, negatively charged tubulin C-terminal tails. The C-terminal tails are regions of heavy post-translational modification (inclduing phosphorylation, acetylation, palmitoylation, sumoylation, polyamination, S-nitrosylation, glutamylation, glycylation) and serve as interaction sites for molecular motors and other associated proteins and thus can tune the activity of these effectors. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Heterodimer - - - - - psi-mi:"MI:0469"(IntAct) P02557(1)|P09734(1) +CPX-1426 Myosin class II complex Myosin class 2 complex 559292 P08964(2)|P53141(2)|Q06580(2) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0003779(actin binding)|GO:0000146(microfilament motor activity)|GO:0016887(ATPase activity)|GO:0005524(ATP binding)|GO:0000920(cell separation after cytokinesis)|GO:0016460(myosin II complex)|GO:0005935(cellular bud neck) complex portal:CPX-1426(complex-primary)|pubmed:24467403(see-also) Building block of the class II myosin bipolar filament, responsible for the anti-parallel sliding of actin filaments. Plays a role in cell separation, appearing to form thick filaments that scaffold the assembly of the division machinery. The myosin heavy chain motor domain mediates the ATP-dependent interaction with the F-actin cytoskeleton. The myosin neck region with the bound light chains acts as a rigid lever arm that amplifies movements within the myosin motor domain into a large mechanical stroke that directionally propels the myosin along the actin filament. The MYO1 molecules dimarize via long apha-helical tails, Heterohexamer - - - - - psi-mi:"MI:0469"(IntAct) P08964(2)|P53141(2)|Q06580(2) +CPX-1470 Myosin class I complex, MYO5 variant Myosin class 1 complex 559292 P06787(0)|Q04439(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-8088247 GO:0000146(microfilament motor activity)|GO:0003779(actin binding)|GO:0005524(ATP binding)|GO:0016887(ATPase activity)|GO:2000601(positive regulation of Arp2/3 complex-mediated actin nucleation)|GO:0006897(endocytosis)|GO:0045160(myosin I complex)|GO:0030479(actin cortical patch) complex portal:CPX-1470(complex-primary)|pubmed:24467403(see-also) Responsible for endocytic internalization. Required for proper actin cytoskeleton assembly polarization via the formation of actin patches. The myosin heavy chain motor domain mediates the ATP-dependent interaction with the F-actin cytoskeleton. The myosin neck region with the bound light chains acts as a rigid lever arm that amplifies movements within the myosin motor domain into a large mechanical stroke that directionally propels the myosin along the actin filament. The C-terminal extension (long-tail) of Myosin-5 can trigger Arp2/3 complex (CPX-607)-dependent actin polymerization. - - - - - - - psi-mi:"MI:0469"(IntAct) P06787(0)|Q04439(0) +CPX-1500 Myosin class I complex, MYO3 variant Myosin class 1 complex 559292 P06787(0)|P36006(0) ECO:0005546(biological system reconstruction evidence based on paralogy evidence used in manual assertion) - GO:0000146(microfilament motor activity)|GO:0003779(actin binding)|GO:0005524(ATP binding)|GO:0016887(ATPase activity)|GO:2000601(positive regulation of Arp2/3 complex-mediated actin nucleation)|GO:0006897(endocytosis)|GO:0045160(myosin I complex)|GO:0030479(actin cortical patch) complex portal:CPX-1470(inferred-from)|complex portal:CPX-1500(complex-primary)|pubmed:24467403(see-also) Responsible for endocytic internalization. Required for proper actin cytoskeleton assembly polarization via the formation of actin patches. The myosin heavy chain motor domain mediates the ATP-dependent interaction with the F-actin cytoskeleton. The myosin neck region with the bound light chains acts as a rigid lever arm that amplifies movements within the myosin motor domain into a large mechanical stroke that directionally propels the myosin along the actin filament. The C-terminal extension (long-tail) of Myosin-5 can trigger Arp2/3 complex (CPX-607)-dependent actin polymerization. - - - - - - - psi-mi:"MI:0469"(IntAct) P06787(0)|P36006(0) +CPX-1501 Myosin class V complex, MYO4 variant Unconventional myosin V complex|Myosin class 5 complex|Myo5 complex 559292 P06787(8)|P32492(2)|P53141(4) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0005524(ATP binding)|GO:0016887(ATPase activity)|GO:0003779(actin binding)|GO:0030050(vesicle transport along actin filament)|GO:0000146(microfilament motor activity)|GO:0031475(myosin V complex) complex portal:CPX-1501(complex-primary)|pubmed:24467403(see-also) Building block of the class V myosin processive molecular motor involved in a range of organelle-transporting functions, including the transport of vacuoles and mRNA. The myosin heavy chain motor domain mediates the ATP-dependent interaction with the F-actin cytoskeleton. The myosin neck region with the bound light chains acts as a rigid lever arm that amplifies movements within the myosin motor domain into a large mechanical stroke that directionally propels the myosin along the actin filament. Myosin V has a high duty cycle, i.e. remains attached to actin for a large fraction of the mechanochemical cycle due to the slow rate of ADP release, the rate-limiting step in the ATPase cycle. This kinetic adaptation allows myosin V to take multiple steps without dissociating from the actin filament. Myosin V can take large steps of approximately 36nm, a distance equal to the helical repeat of the actin filament allowing Myosin V to walk in a straight line on the actin filament, in a hand-over-hand fashion. MYO4 contains an N‐terminal ‘head’ or motor domain, containing the actin‐binding and ATP catalytic sites, followed by an extended ‘neck’ domain formed by six in‐tandem IQ motifs. Following the neck is the ‘tail’ domain, which contains a region predicted to form a coiled‐coil and a C‐terminal globular domain. The IQ motifs constitute the binding sites for Ca2+‐free (or apo) Calmodulin (CaM) and CaM‐like light chains. IQ motifs are approximately 25 amino acids long with the consensus sequence IQxxxRGxxxR. Apo‐CaM is the primary light chain of myosin V, occupying approximately four out of the six IQ sites, however binding of the light chain MLC1 is essential. - - - - - - psi-mi:"MI:0469"(IntAct) P06787(8)|P32492(2)|P53141(4) +CPX-1556 CMG-Pol epsilon complex - 559292 CPX-2110(0)|CPX-297(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0003887(DNA-directed DNA polymerase activity)|GO:0003678(DNA helicase activity)|GO:0005524(ATP binding)|GO:0043596(nuclear replication fork)|GO:0003697(single-stranded DNA binding)|GO:0005634(nucleus) pubmed:25313033(see-also)|intenz:2.7.7.7(identity)|intenz:3.6.4.12(identity)|complex portal:CPX-1556(complex-primary) Functions in leading-strand replication, concurrently unwinding and synthesizing DNA on the leading strand. - Heteropentadecamer - - - - - psi-mi:"-"(Saccharomyces Genome Database) P21951(0)|P24279(0)|P24482(0)|P27344(0)|P29469(0)|P29496(0)|P30665(0)|P38132(0)|P40359(0)|P53091(0)|Q03406(0)|Q04603(0)|Q08032(0)|Q12146(0)|Q12488(0) +CPX-1599 40S cytosolic small ribosomal subunit SSU 559292 P05750(1)|P05756(1)|P05759(1)|P25443(1)|P26783(1)|P38011(1)|P38701(1)|P48589(1)|Q01855(1)|URS00005F2C2D_559292(1)|[O13516,P05755](1)|[P02407,P14127](1)|[P06367,P39516](1)|[P07281,P07280](1)|[P0C0V8,Q3E754](1)|[P0C0W1,Q3E7Y3](1)|[P0CX30,P0CX29](1)|[P0CX31,P0CX32](1)|[P0CX34,P0CX33](1)|[P0CX36,P0CX35](1)|[P0CX37,P0CX38](1)|[P0CX39,P0CX40](1)|[P0CX47,P0CX48](1)|[P0CX51,P0CX52](1)|[P0CX55,P0CX56](1)|[P26786,P48164](1)|[P32905,P46654](1)|[P33442,P23248](1)|[P35997,P38711](1)|[P39938,P39939](1)|[P41057,P41058](1)|[Q08745,P46784](1)|[Q3E792,P0C0T4](1)|[Q3E7X9,P0C0X0](1) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0002181(cytoplasmic translation)|GO:0022627(cytosolic small ribosomal subunit)|GO:0045182(translation regulator activity)|GO:0005737(cytoplasm)|GO:0000049(tRNA binding) complex portal:CPX-1599(complex-primary)|pubmed:29155690(see-also)|emdb:EMD-3886(identity)|pubmed:26565899(see-also)|pubmed:26686636(see-also) Component of the ribosome, the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). Acts as the decoding centre of the ribosome which brings mRNA and aminoacylated transfer (t)RNAs together, with the 16S ribosomal (r)RNA being required for the selection of the cognate tRNA. Due to genome duplication, believed to have been caused by two different ancestral species mating followed by substantial losses of duplicated genes through degenerative processes, the 33 different proteins of the small ribosomal subunit are encoded by 57 genes. It has been suggested that, for each duplicated gene, one ribosomal protein gene (RPG) may provide most of the expressed transcript needed for growth under normal condition, while the other provides the extra RP protein amounts and/or function needed for optimum growth in response to a changing environment. The core of the 40S subunit is formed by the 18S ribosomal RNA, whilst the ribosomal proteins create binding sites for the mRNA and the tRNA A-site, P-site and E-site. Whilst there is normally considered a single copy of each polymer in the mature ribosome, there is evidence that the composition can vary in response to physiological conditions, potentially altering the translational efficiency of distinct mRNAs. Hetero-34mer - - - - - psi-mi:"MI:0469"(IntAct) P05750(1)|P05756(1)|P05759(1)|P25443(1)|P26783(1)|P38011(1)|P38701(1)|P48589(1)|Q01855(1)|[O13516,P05755](1)|[P02407,P14127](1)|[P06367,P39516](1)|[P07281,P07280](1)|[P0C0V8,Q3E754](1)|[P0C0W1,Q3E7Y3](1)|[P0CX30,P0CX29](1)|[P0CX31,P0CX32](1)|[P0CX34,P0CX33](1)|[P0CX36,P0CX35](1)|[P0CX37,P0CX38](1)|[P0CX39,P0CX40](1)|[P0CX47,P0CX48](1)|[P0CX51,P0CX52](1)|[P0CX55,P0CX56](1)|[P26786,P48164](1)|[P32905,P46654](1)|[P33442,P23248](1)|[P35997,P38711](1)|[P39938,P39939](1)|[P41057,P41058](1)|[Q08745,P46784](1)|[Q3E792,P0C0T4](1)|[Q3E7X9,P0C0X0](1) +CPX-1601 60S cytosolic large ribosomal subunit LSU 559292 P02406(1)|P04650(1)|P05317(1)|P05747(1)|P14120(1)|P14126(1)|P26321(1)|P38061(2)|P41805(1)|P49167(1)|URS00001BF64E_559292(1)|URS000055688D_559292(1)|URS000061F377_559292(1)|[P02400,P05319](1)|[P04449,P24000](1)|[P05318,P10622](1)|[P05737,Q12213](1)|[P05738,P51401](1)|[P05740,P46990](1)|[P05743,P53221](1)|[P05744,P41056](1)|[P05745,O14455](1)|[P05748,P54780](1)|[P0C0W9,Q3E757](1)|[P0C2H6,P0C2H7](1)|[P0C2H8,P0C2H9](1)|[P0CH09,P0CH08](1)|[P0CX23,P0CX24](1)|[P0CX26,P0CX25](1)|[P0CX28,P0CX27](1)|[P0CX41,P0CX42](1)|[P0CX43,P0CX44](1)|[P0CX46,P0CX45](1)|[P0CX50,P0CX49](1)|[P0CX53,P0CX54](1)|[P0CX82,P0CX83](1)|[P0CX84,P0CX85](1)|[P0CX86,P0CX87](1)|[P10664,P49626](1)|[P17076,P29453](1)|[P26784,P26785](1)|[P36105,P38754](1)|[P49166,P51402](1)|[P56628,P05749](1)|[P87262,P40525](1)|[Q02326,P05739](1)|[Q02753,Q12672](1)|[Q12690,P40212](1) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0022625(cytosolic large ribosomal subunit)|GO:0002181(cytoplasmic translation)|GO:0005737(cytoplasm)|GO:0045182(translation regulator activity)|GO:0000048(peptidyltransferase activity) complex portal:CPX-1601(complex-primary) Component of the ribosome, the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). Responsible for the catalytic activity of the ribosome, the peptidyltransferase activity required to catalyze peptide bond formation. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. Due to genome duplication, believed to have been caused by two different ancestral species mating followed by substantial losses of duplicated genes through degenerative processes, the 46 different proteins of the large ribosomal subunit are encoded by 81 genes. It has been suggested that, for each duplicated gene, one ribosomal protein gene (RPG) may provide most of the expressed transcript needed for growth under normal condition, while the other provides the extra RP protein amounts and/or function needed for optimum growth in response to a changing environment. A distinct lateral protuberance called the stalk is located on the large ribosomal subuniit and plays a central role in the ribosome-mediated stimulation of translation factor-dependent GTP hydrolysis. The 5 acidic ribosomal P-proteins form the pentameric stalk. - - - - - - psi-mi:"MI:0469"(IntAct) P02406(1)|P04650(1)|P05317(1)|P05747(1)|P14120(1)|P14126(1)|P26321(1)|P38061(2)|P41805(1)|P49167(1)|[P02400,P05319](1)|[P04449,P24000](1)|[P05318,P10622](1)|[P05737,Q12213](1)|[P05738,P51401](1)|[P05740,P46990](1)|[P05743,P53221](1)|[P05744,P41056](1)|[P05745,O14455](1)|[P05748,P54780](1)|[P0C0W9,Q3E757](1)|[P0C2H6,P0C2H7](1)|[P0C2H8,P0C2H9](1)|[P0CH09,P0CH08](1)|[P0CX23,P0CX24](1)|[P0CX26,P0CX25](1)|[P0CX28,P0CX27](1)|[P0CX41,P0CX42](1)|[P0CX43,P0CX44](1)|[P0CX46,P0CX45](1)|[P0CX50,P0CX49](1)|[P0CX53,P0CX54](1)|[P0CX82,P0CX83](1)|[P0CX84,P0CX85](1)|[P0CX86,P0CX87](1)|[P10664,P49626](1)|[P17076,P29453](1)|[P26784,P26785](1)|[P36105,P38754](1)|[P49166,P51402](1)|[P56628,P05749](1)|[P87262,P40525](1)|[Q02326,P05739](1)|[Q02753,Q12672](1)|[Q12690,P40212](1) +CPX-1602 54S mitochondrial large ribosomal subunit mt-LSU 559292 O14464(1)|P12687(1)|P14063(1)|P19956(1)|P20084(1)|P22353(1)|P22354(1)|P23369(1)|P25348(1)|P25626(1)|P25642(1)|P31334(1)|P32387(1)|P32388(1)|P32611(1)|P32904(1)|P35996(1)|P36516(1)|P36517(1)|P36519(1)|P36520(1)|P36521(1)|P36523(1)|P36525(1)|P36526(1)|P36527(1)|P36528(1)|P36531(1)|P36532(1)|P36533(1)|P36534(1)|P38064(1)|P40858(1)|P51998(1)|P53163(1)|P53724(1)|P53875(1)|P53881(1)|P53921(1)|Q02204(1)|Q04598(1)|Q04599(1)|Q06090(1)|Q06630(1)|Q06678(1)|Q12487(1)|URS00007F9EA9_559292(1) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0005762(mitochondrial large ribosomal subunit)|GO:0005743(mitochondrial inner membrane)|GO:0000048(peptidyltransferase activity)|GO:0045182(translation regulator activity)|GO:0032543(mitochondrial translation) complex portal:CPX-1602(complex-primary)|pubmed:28154081(see-also)|wwpdb:3j6b(subset)|pubmed:25609543(see-also) Component of the ribosome, the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). Responsible for the catalytic activity of the ribosome, the peptidyltransferase activity required to catalyze peptide bond formation. The mitochondrial ribosome (mitoribosome) is responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are tethered to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane. The inner membrane protein MBA1 (P38300) aligns the mitochondrial peptide exit tunnel with the membrane insertion machinery and supports the transfer of the mitochondrial nascent peptides towards the membrane A distinct lateral protuberance called the stalk is located on the large ribosomal subuniit and plays a central role in the ribosome-mediated stimulation of translation factor-dependent GTP hydrolysis. - - - - - - psi-mi:"MI:0469"(IntAct) O14464(1)|P12687(1)|P14063(1)|P19956(1)|P20084(1)|P22353(1)|P22354(1)|P23369(1)|P25348(1)|P25626(1)|P25642(1)|P31334(1)|P32387(1)|P32388(1)|P32611(1)|P32904(1)|P35996(1)|P36516(1)|P36517(1)|P36519(1)|P36520(1)|P36521(1)|P36523(1)|P36525(1)|P36526(1)|P36527(1)|P36528(1)|P36531(1)|P36532(1)|P36533(1)|P36534(1)|P38064(1)|P40858(1)|P51998(1)|P53163(1)|P53724(1)|P53875(1)|P53881(1)|P53921(1)|Q02204(1)|Q04598(1)|Q04599(1)|Q06090(1)|Q06630(1)|Q06678(1)|Q12487(1) +CPX-1603 37S mitochondrial small ribosomal subunit mitoribosome 559292 O75012(1)|P02381(1)|P10662(1)|P10663(1)|P12686(1)|P17558(1)|P21771(1)|P27929(1)|P28778(1)|P28817(1)|P32344(1)|P32902(1)|P33759(1)|P38120(1)|P38175(1)|P38783(1)|P40033(1)|P40496(1)|P42847(1)|P47141(1)|P47150(1)|P53292(1)|P53305(1)|P53732(1)|P53733(1)|P53937(1)|Q01163(1)|Q02608(1)|Q02950(1)|Q03201(1)|Q03246(1)|Q03430(1)|Q03799(1)|Q03976(1)|URS000060F99B_559292(1) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0005743(mitochondrial inner membrane)|GO:0005763(mitochondrial small ribosomal subunit)|GO:0000049(tRNA binding)|GO:0032543(mitochondrial translation)|GO:0045182(translation regulator activity) complex portal:CPX-1603(complex-primary)|pubmed:28154081(see-also)|pubmed:25609543(see-also) Component of the ribsome, the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). Acts as the decoding centre of the ribosome which brings mRNA and aminoacylated transfer (t)RNAs. The mitochondrial ribosome (mitoribosome) is responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are tethered to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane. The inner membrane protein MBA1 (P38300) aligns the mitochondrial peptide exit tunnel with the membrane insertion machinery and supports the transfer of the mitochondrial nascent peptides towards the membrane - - - - - - - psi-mi:"MI:0469"(IntAct) O75012(1)|P02381(1)|P10662(1)|P10663(1)|P12686(1)|P17558(1)|P21771(1)|P27929(1)|P28778(1)|P28817(1)|P32344(1)|P32902(1)|P33759(1)|P38120(1)|P38175(1)|P38783(1)|P40033(1)|P40496(1)|P42847(1)|P47141(1)|P47150(1)|P53292(1)|P53305(1)|P53732(1)|P53733(1)|P53937(1)|Q01163(1)|Q02608(1)|Q02950(1)|Q03201(1)|Q03246(1)|Q03430(1)|Q03799(1)|Q03976(1) +CPX-1604 Small ribosomal subunit processome, variant 1 Small-subunit processome|SSU processome complex 559292 CPX-1409(0)|CPX-1410(0)|CPX-1606(0)|CPX-1735(0)|CPX-1893(0)|CPX-772(0)|P15646(0)|P20448(0)|P25586(0)|P27476(0)|P33201(0)|P33750(0)|P34078(0)|P34247(0)|P35194(0)|P36009(0)|P36144(0)|P38333(0)|P38712(0)|P38719(0)|P39985(0)|P39990(0)|P40055(0)|P40079(0)|P40498(0)|P45818(0)|P47077(0)|P53131(0)|P53251(0)|P53317(0)|P53335(0)|P53743(0)|P53914(0)|Q00416(0)|Q03532(0)|Q04217(0)|Q04500(0)|Q05022(0)|Q05498(0)|Q06106(0)|Q06132(0)|Q06287(0)|Q06344(0)|Q06506(0)|Q07623(0)|Q08492(0)|Q12099(0)|Q12136(0)|Q12247(0)|Q12339(0)|Q12460(0)|Q12481(0)|Q12499(0)|URS0000444F9B_559292(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0005730(nucleolus)|GO:0032040(small-subunit processome)|GO:0030515(snoRNA binding)|GO:0030490(maturation of SSU-rRNA) complex portal:CPX-1604(complex-primary)|wwpdb:4clq(subset)|wwpdb:5tzs(subset)|emdb:EMD-8473(identity)|pubmed:27980088(see-also) Required for the processing, assembly and maturation of nascent pre-ribosomal RNA to form the small ribosomal subunit (SSU). The SSU processome is a giant particle composed of numerous ribosome assembly factors, including the UTP-A (CPX-1409), UTP-B (CPX-1410), UTP-C (CPX-772/CPX-771/CPX-773) and MPP10 (CPX-1893) complexes, the U3 small nucleolar ribonucleoprotein (snoRNP) and many individual proteins. Acts in the nucleolus to cleave the polycistronic precursor pre-rRNA in the 5-prime external transcribed spacer (ETS) sequence and in the internal transcribed spacer 1 (ITS1) sequence, to separate small and large subunit biogenesis. The nascent SSU is then exported from the nucleolus to the cytoplasm, where the final cleavage occurs to form the mature 40S SSU containing the 18S rRNA. The nuclease FCF1 and the molecular motor BMS1 cause structural changes within the mature processome which facilitate the subsequent cleavage reactions. UTP-A (CPX-1409) forms the base of the SSU processome, where it acts as a central scaffold that recognizes the first three helices of the 5-prime ETS. U3 snoRNA occupies a central position within the SSU processome and reaches from the outside into the core of the particle. By base-pairing with its 5-prime and 3-prime hinges to nucleotides within the 5-prime ETS, it rigidifies the structural scaffold provided by the 5-prime ETS. The 5-prime end of U3 snoRNA reaches further into the center of the SSU processome and base-pairs with two regions of the pre-18S rRNA. The GTPase BMS1 and the MPP10 complex (CPX-1893) are positioned in the core of the SSU processome - - - - - - psi-mi:"MI:0469"(IntAct) P15646(0)|P15790(0)|P19454(0)|P20448(0)|P25368(0)|P25586(0)|P25635(0)|P27476(0)|P32899(0)|P33201(0)|P33750(0)|P34078(0)|P34247(0)|P35194(0)|P36009(0)|P36144(0)|P38333(0)|P38712(0)|P38719(0)|P38882(0)|P38930(0)|P39985(0)|P39990(0)|P40055(0)|P40079(0)|P40362(0)|P40498(0)|P42945(0)|P43639(0)|P45818(0)|P47077(0)|P47083(0)|P53131(0)|P53251(0)|P53254(0)|P53276(0)|P53317(0)|P53335(0)|P53743(0)|P53914(0)|P53941(0)|Q00416(0)|Q02354(0)|Q02931(0)|Q03532(0)|Q04177(0)|Q04217(0)|Q04305(0)|Q04500(0)|Q05022(0)|Q05498(0)|Q05946(0)|Q06078(0)|Q06106(0)|Q06132(0)|Q06287(0)|Q06344(0)|Q06506(0)|Q06512(0)|Q06679(0)|Q07623(0)|Q08096(0)|Q08492(0)|Q08965(0)|Q12099(0)|Q12136(0)|Q12220(0)|Q12247(0)|Q12339(0)|Q12460(0)|Q12481(0)|Q12499(0)|Q99207(0) +CPX-1606 RCL1-BMS1 40S ribosomal subunit maturation complex - 559292 CHEBI:15996(0)|Q08096(1)|Q08965(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-2290722 GO:0070181(small ribosomal subunit rRNA binding)|GO:0042274(ribosomal small subunit biogenesis)|GO:0003924(GTPase activity)|GO:0005730(nucleolus)|GO:2000232(regulation of rRNA processing) complex portal:CPX-1606(complex-primary)|wwpdb:4CLQ(identity) Required for 40S ribosomal subunit maturation. Formation of the complex is required for the import of RCL1 into the nucleus. In the absence of GTP, BMS1 acts as a chaperone and masks the RCL1 active site. GTP binding to BMS1 and/or GTP hydrolysis unveils the RNA binding surface of RCL1 and promotes 20S pre-rRNA cleavage to form the mature 18S RNA. - Heterodimer - - - - - psi-mi:"MI:0469"(IntAct) Q08096(1)|Q08965(1) +CPX-1607 Small ribosomal subunit processome, variant 2 Small-subunit processome|SSU processome complex 559292 CPX-1409(0)|CPX-1410(0)|CPX-1606(0)|CPX-1735(0)|CPX-1893(0)|CPX-771(0)|P15646(0)|P20448(0)|P25586(0)|P27476(0)|P33201(0)|P33750(0)|P34078(0)|P34247(0)|P35194(0)|P36009(0)|P36144(0)|P38333(0)|P38712(0)|P38719(0)|P39985(0)|P39990(0)|P40055(0)|P40079(0)|P40498(0)|P45818(0)|P47077(0)|P53131(0)|P53251(0)|P53317(0)|P53335(0)|P53743(0)|P53914(0)|Q00416(0)|Q03532(0)|Q04217(0)|Q04500(0)|Q05022(0)|Q05498(0)|Q06106(0)|Q06132(0)|Q06287(0)|Q06344(0)|Q06506(0)|Q07623(0)|Q08492(0)|Q12099(0)|Q12136(0)|Q12247(0)|Q12339(0)|Q12460(0)|Q12481(0)|Q12499(0)|URS0000444F9B_559292(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0005730(nucleolus)|GO:0032040(small-subunit processome)|GO:0030515(snoRNA binding)|GO:0030490(maturation of SSU-rRNA) complex portal:CPX-1607(complex-primary)|wwpdb:4clq(subset)|pubmed:27980088(see-also) Required for the processing, assembly and maturation of nascent pre-ribosomal RNA to form the small ribosomal subunit (SSU). The SSU processome is a giant particle composed of numerous ribosome assembly factors, including the UTP-A (CPX-1409), UTP-B (CPX-1410), UTP-C (CPX-772/CPX-771/CPX-773) and MPP10 (CPX-1893) complexes, the U3 small nucleolar ribonucleoprotein (snoRNP) and many individual proteins. Acts in the nucleolus to cleave the polycistronic precursor pre-rRNA in the 5-prime external transcribed spacer (ETS) sequence and in the internal transcribed spacer 1 (ITS1) sequence, to separate small and large subunit biogenesis. The nascent SSU is then exported from the nucleolus to the cytoplasm, where the final cleavage occurs to form the mature 40S SSU containing the 18S rRNA. The nuclease FCF1 and the molecular motor BMS1 cause structural changes within the mature processome which facilitate the subsequent cleavage reactions. UTP-A (CPX-1409) forms the base of the SSU processome, where it acts as a central scaffold that recognizes the first three helices of the 5-prime ETS. U3 snoRNA occupies a central position within the SSU processome and reaches from the outside into the core of the particle. By base-pairing with its 5-prime and 3-prime hinges to nucleotides within the 5-prime ETS, it rigidifies the structural scaffold provided by the 5-prime ETS. The 5-prime end of U3 snoRNA reaches further into the center of the SSU processome and base-pairs with two regions of the pre-18S rRNA. The GTPase BMS1 and the MPP10 complex (CPX-1893) are positioned in the core of the SSU processome - - - - - - psi-mi:"MI:0469"(IntAct) P15646(0)|P15790(0)|P20448(0)|P25368(0)|P25586(0)|P25635(0)|P27476(0)|P32899(0)|P33201(0)|P33750(0)|P34078(0)|P34247(0)|P35194(0)|P36009(0)|P36144(0)|P38333(0)|P38712(0)|P38719(0)|P38882(0)|P38930(0)|P39985(0)|P39990(0)|P40055(0)|P40079(0)|P40362(0)|P40498(0)|P42945(0)|P43639(0)|P45818(0)|P47077(0)|P47083(0)|P53131(0)|P53251(0)|P53254(0)|P53276(0)|P53317(0)|P53335(0)|P53743(0)|P53914(0)|P53941(0)|Q00416(0)|Q02354(0)|Q02931(0)|Q03532(0)|Q04177(0)|Q04217(0)|Q04305(0)|Q04500(0)|Q05022(0)|Q05498(0)|Q05946(0)|Q06078(0)|Q06106(0)|Q06132(0)|Q06287(0)|Q06344(0)|Q06506(0)|Q06512(0)|Q06679(0)|Q07623(0)|Q08096(0)|Q08492(0)|Q08965(0)|Q12099(0)|Q12136(0)|Q12220(0)|Q12247(0)|Q12339(0)|Q12460(0)|Q12481(0)|Q12499(0)|Q99207(0) +CPX-1608 Small ribosomal subunit processome, variant 3 Small-subunit processome|SSU processome complex 559292 CPX-1409(0)|CPX-1410(0)|CPX-1606(0)|CPX-1735(0)|CPX-1893(0)|CPX-773(0)|P15646(0)|P20448(0)|P25586(0)|P27476(0)|P33201(0)|P33750(0)|P34078(0)|P34247(0)|P35194(0)|P36009(0)|P36144(0)|P38333(0)|P38712(0)|P38719(0)|P39985(0)|P39990(0)|P40055(0)|P40079(0)|P40498(0)|P45818(0)|P47077(0)|P53131(0)|P53251(0)|P53317(0)|P53335(0)|P53743(0)|P53914(0)|Q00416(0)|Q03532(0)|Q04217(0)|Q04500(0)|Q05022(0)|Q05498(0)|Q06106(0)|Q06132(0)|Q06287(0)|Q06344(0)|Q06506(0)|Q07623(0)|Q08492(0)|Q12099(0)|Q12136(0)|Q12247(0)|Q12339(0)|Q12460(0)|Q12481(0)|Q12499(0)|URS0000444F9B_559292(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0005730(nucleolus)|GO:0032040(small-subunit processome)|GO:0030515(snoRNA binding)|GO:0030490(maturation of SSU-rRNA) complex portal:CPX-1608(complex-primary)|wwpdb:4clq(subset)|pubmed:27980088(see-also) Required for the processing, assembly and maturation of nascent pre-ribosomal RNA to form the small ribosomal subunit (SSU). The SSU processome is a giant particle composed of numerous ribosome assembly factors, including the UTP-A (CPX-1409), UTP-B (CPX-1410), UTP-C (CPX-772/CPX-771/CPX-773) and MPP10 (CPX-1893) complexes, the U3 small nucleolar ribonucleoprotein (snoRNP) and many individual proteins. Acts in the nucleolus to cleave the polycistronic precursor pre-rRNA in the 5-prime external transcribed spacer (ETS) sequence and in the internal transcribed spacer 1 (ITS1) sequence, to separate small and large subunit biogenesis. The nascent SSU is then exported from the nucleolus to the cytoplasm, where the final cleavage occurs to form the mature 40S SSU containing the 18S rRNA. The nuclease FCF1 and the molecular motor BMS1 cause structural changes within the mature processome which facilitate the subsequent cleavage reactions. UTP-A (CPX-1409) forms the base of the SSU processome, where it acts as a central scaffold that recognizes the first three helices of the 5-prime ETS. U3 snoRNA occupies a central position within the SSU processome and reaches from the outside into the core of the particle. By base-pairing with its 5-prime and 3-prime hinges to nucleotides within the 5-prime ETS, it rigidifies the structural scaffold provided by the 5-prime ETS. The 5-prime end of U3 snoRNA reaches further into the center of the SSU processome and base-pairs with two regions of the pre-18S rRNA. The GTPase BMS1 and the MPP10 complex (CPX-1893) are positioned in the core of the SSU processome - - - - - - psi-mi:"MI:0469"(IntAct) P15646(0)|P19454(0)|P20448(0)|P25368(0)|P25586(0)|P25635(0)|P27476(0)|P32899(0)|P33201(0)|P33750(0)|P34078(0)|P34247(0)|P35194(0)|P36009(0)|P36144(0)|P38333(0)|P38712(0)|P38719(0)|P38882(0)|P38930(0)|P39985(0)|P39990(0)|P40055(0)|P40079(0)|P40362(0)|P40498(0)|P42945(0)|P43639(0)|P45818(0)|P47077(0)|P47083(0)|P53131(0)|P53251(0)|P53254(0)|P53276(0)|P53317(0)|P53335(0)|P53743(0)|P53914(0)|P53941(0)|Q00416(0)|Q02354(0)|Q02931(0)|Q03532(0)|Q04177(0)|Q04217(0)|Q04305(0)|Q04500(0)|Q05022(0)|Q05498(0)|Q05946(0)|Q06078(0)|Q06106(0)|Q06132(0)|Q06287(0)|Q06344(0)|Q06506(0)|Q06512(0)|Q06679(0)|Q07623(0)|Q08096(0)|Q08492(0)|Q08965(0)|Q12099(0)|Q12136(0)|Q12220(0)|Q12247(0)|Q12339(0)|Q12460(0)|Q12481(0)|Q12499(0)|Q99207(0) +CPX-1610 Nucleosome, variant HTA2-HTB2 - 559292 CHEBI:4705(1)|P02294(2)|P02309(2)|P04912(2)|P61830(2) ECO:0005546(biological system reconstruction evidence based on paralogy evidence used in manual assertion) - GO:0000786(nucleosome)|GO:0006333(chromatin assembly or disassembly)|GO:0005634(nucleus) complex portal:CPX-1610(complex-primary) Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. 1.65 tight superhelical turns of 147 base pairs of DNA are wrapped around a histone octamer to form the nucleosome core. The H3-H4 heterodimers pair to form a tetramer through interactions of a four-helix bundle (alpha2 and alpha3 of H3 from each dimer). The association of this (H3-H4)2 tetramer with DNA is the first step in nucleosome assembly. Each H2A-H2B heterodimer binds to the (H3-H4)2 tetramer via another, homologous, four-helix bundle (alpha2 and alpha3 from both H2B and H4), joining the H2B and H4 histone folds. - - - - - - psi-mi:"MI:0469"(IntAct) P02294(2)|P02309(2)|P04912(2)|P61830(2) +CPX-1611 Nucleosome, variant HTA2-HTB1 - 559292 CHEBI:4705(1)|P02293(2)|P02309(2)|P04912(2)|P61830(2) ECO:0005546(biological system reconstruction evidence based on paralogy evidence used in manual assertion) - GO:0000786(nucleosome)|GO:0006333(chromatin assembly or disassembly)|GO:0005634(nucleus) complex portal:CPX-1611(complex-primary) Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. 1.65 tight superhelical turns of 147 base pairs of DNA are wrapped around a histone octamer to form the nucleosome core. The H3-H4 heterodimers pair to form a tetramer through interactions of a four-helix bundle (alpha2 and alpha3 of H3 from each dimer). The association of this (H3-H4)2 tetramer with DNA is the first step in nucleosome assembly. Each H2A-H2B heterodimer binds to the (H3-H4)2 tetramer via another, homologous, four-helix bundle (alpha2 and alpha3 from both H2B and H4), joining the H2B and H4 histone folds. - - - - - - psi-mi:"MI:0469"(IntAct) P02293(2)|P02309(2)|P04912(2)|P61830(2) +CPX-1612 Nucleosome, variant HTA1-HTB1 - 559292 CHEBI:4705(1)|P02293(2)|P02309(2)|P04911(2)|P61830(2) ECO:0005546(biological system reconstruction evidence based on paralogy evidence used in manual assertion) - GO:0000786(nucleosome)|GO:0006333(chromatin assembly or disassembly)|GO:0005634(nucleus) complex portal:CPX-1612(complex-primary) Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. 1.65 tight superhelical turns of 147 base pairs of DNA are wrapped around a histone octamer to form the nucleosome core. The H3-H4 heterodimers pair to form a tetramer through interactions of a four-helix bundle (alpha2 and alpha3 of H3 from each dimer). The association of this (H3-H4)2 tetramer with DNA is the first step in nucleosome assembly. Each H2A-H2B heterodimer binds to the (H3-H4)2 tetramer via another, homologous, four-helix bundle (alpha2 and alpha3 from both H2B and H4), joining the H2B and H4 histone folds. - - - - - - psi-mi:"MI:0469"(IntAct) P02293(2)|P02309(2)|P04911(2)|P61830(2) +CPX-1613 Nucleosome, variant HTZ1-HTB1 - 559292 CHEBI:4705(1)|P02293(2)|P02309(2)|P61830(2)|Q12692(2) ECO:0005546(biological system reconstruction evidence based on paralogy evidence used in manual assertion) - GO:0000786(nucleosome)|GO:0006333(chromatin assembly or disassembly)|GO:0005634(nucleus)|GO:0006355(regulation of transcription, DNA-templated) complex portal:CPX-1613(complex-primary) Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. The H2A.Z nucleosome acts as a barrier that occludes the transcription start sites at the edge of the nucleosome-free region, potentially keeping promoters in a repressed state. The complex additionally helps position downstream nucleosomes in the coding region. SWR1 (CPX-2122) replaces the canonical H2A/H2B dimer at nucleosomes flanking histone-depleted regions, such as promoters, with the variant histone H2A.Z/H2B dimer. 1.65 tight superhelical turns of 147 base pairs of DNA are wrapped around a histone octamer to form the nucleosome core. The H3-H4 heterodimers pair to form a tetramer through interactions of a four-helix bundle (alpha2 and alpha3 of H3 from each dimer). The association of this (H3-H4)2 tetramer with DNA is the first step in nucleosome assembly. Each H2A-H2B heterodimer binds to the (H3-H4)2 tetramer via another, homologous, four-helix bundle (alpha2 and alpha3 from both H2B and H4), joining the H2B and H4 histone folds. - - - - - - psi-mi:"MI:0469"(IntAct) P02293(2)|P02309(2)|P61830(2)|Q12692(2) +CPX-1614 Nucleosome, variant HTZ1-HTB2 - 559292 CHEBI:4705(1)|P02294(2)|P02309(2)|P61830(2)|Q12692(2) ECO:0005546(biological system reconstruction evidence based on paralogy evidence used in manual assertion) - GO:0006355(regulation of transcription, DNA-templated)|GO:0000786(nucleosome)|GO:0006333(chromatin assembly or disassembly)|GO:0005634(nucleus) complex portal:CPX-1614(complex-primary) Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. The H2A.Z nucleosome acts as a barrier that occludes the transcription start sites at the edge of the nucleosome-free region, potentially keeping promoters in a repressed state. The complex additionally helps position downstream nucleosomes in the coding region. SWR1 (CPX-2122) replaces the canonical H2A/H2B dimer at nucleosomes flanking histone-depleted regions, such as promoters, with the variant histone H2A.Z/H2B dimer. 1.65 tight superhelical turns of 147 base pairs of DNA are wrapped around a histone octamer to form the nucleosome core. The H3-H4 heterodimers pair to form a tetramer through interactions of a four-helix bundle (alpha2 and alpha3 of H3 from each dimer). The association of this (H3-H4)2 tetramer with DNA is the first step in nucleosome assembly. Each H2A-H2B heterodimer binds to the (H3-H4)2 tetramer via another, homologous, four-helix bundle (alpha2 and alpha3 from both H2B and H4), joining the H2B and H4 histone folds. - - - - - - psi-mi:"MI:0469"(IntAct) P02294(2)|P02309(2)|P61830(2)|Q12692(2) +CPX-1616 Clathrin complex - 559292 P17891(3)|P22137(3) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-16747190 GO:0005198(structural molecule activity)|GO:0048268(clathrin coat assembly)|GO:0071439(clathrin complex) complex portal:CPX-1616(complex-primary) Building block of the polyhedral coat of coated pits and vesicles, forming a polymeric mechanical scaffold on the vesicle surface. Clathrin-coated vesicles participate in selective protein transport processes from the plasma membrane and the Golgi complex, including endocytosis, sorting of newly made lysosomal proteins, secretory granule formation and localization of certain Golgi membrane proteins. The three clathrin heavy chains and three clathrin light chains are organized into a symmetrical three-legged structure called a triskelion - - - - - - psi-mi:"MI:0469"(IntAct) P17891(3)|P22137(3) +CPX-3342 Seipin complex - 559292 P25587(0)|Q06058(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-16426925 GO:1990044(protein localization to lipid droplet)|GO:0140042(lipid droplet formation)|GO:0030176(integral component of endoplasmic reticulum membrane)|GO:0019216(regulation of lipid metabolic process)|GO:0005811(lipid droplet) pubmed:24434579(see-also)|pubmed:26572621(see-also)|pubmed:21062080(see-also)|pubmed:26275961(see-also)|complex portal:CPX-3342(complex-primary) Required for resulating the size, morphology and content of lipid droplets. Acts to stabilize the contact points between the endoplasmic reticulum and lipid droplet, preventing the equilibration of the two membrane systems and establishing a diffusion barrier. The complex modulates the balance between neutral lipid and phospholipid synthesis and appears to affect the distribution of enzymes involved in phosphatidic acid to diacyl glycerol conversion. Mutations in human seipin cause lipodystrophy. - homooligomer - A212P mutation in human seipin is linked to lipodystrophy - - - psi-mi:"-"(Saccharomyces Genome Database) P25587(0)|Q06058(0) +CPX-3384 LAS1 RNA processome complex LAS1-GRC3-RAT1-RAI1 complex 559292 CPX-1332(0)|P36146(2)|Q07845(2) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) intact:EBI-1551805 GO:0019843(rrna binding)|GO:0004534(5'-3' exoribonuclease activity)|GO:0034353(RNA pyrophosphohydrolase activity)|GO:0005634(nucleus)|GO:0000448(cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA))|GO:0005524(atp binding)|GO:0090730(Las1 complex) intenz:3.1.13(identity)|intenz:3.6.1(identity)|pubmed:26638174(see-also)|complex portal:CPX-3384(complex-primary)|intenz:2.7.1(identity) Endonuclease responsible for the removal of the second internal transcribed spacer region (ITS2) from 35S pre-ribosomal RNA, located between the 5.8S and 25S rRNA. LAS1 within this complex functions as RNA endonuclease, which cleaves at site C2, yielding a 2′,3′ cyclic phosphate at the 7S pre-rRNA and a hydroxyl group at the 5′ end of the 26S pre-rRNA. Subsequently, GRC3, phosphorylates 26S pre-rRNA at its free 5′-OH group, allowing the associated RAT1 5′ to 3′ exonuclease and its co-factor RAI1 to trim 26S pre-rRNA to 25′S pre-rRNA. - - - - - - - psi-mi:"MI:0469"(IntAct) P36146(2)|P53063(0)|Q02792(0)|Q07845(2) +CPX-3462 CLA4-BEM1-CDC24 polarity complex - 559292 P11433(1)|P29366(1)|P48562(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-20190860 GO:0000282(cellular bud site selection)|GO:0005085(guanyl-nucleotide exchange factor activity)|GO:0035023(regulation of Rho protein signal transduction)|GO:0000131(incipient cellular bud site)|GO:0004674(protein serine/threonine kinase activity)|GO:0120157(PAR polarity complex) complex portal:CPX-3462(complex-primary)|wwpdb:2KFK(subset)|intenz:2.7.11.1(identity)|pubmed:22500799(see-also)|pubmed:28682236(see-also) Required for the establishment of cell polarity during the cell division cycle, and essential for bud emergence. Binds directly to activated CDC42 GTPase and is required for orchestrating a cellular gradient of CDC42. The complex assembles in late G1 and BEM1 directly augments the guanine exchange factor (GEF) activity of CDC24, promoting the exchange of CDC42-bound GDP with GTP. BEM1 also increases CDC24 phosphorylation by CLA4. Phosphorylation inhibits scaffold-dependent stimulation of CDC24 GEF activity, thus BEM1 stimulates GEF activity in a reversible fashion, controlling the flux of cellular signalling through CDC42. The core circuit appears to be a positive feedback loop with GTP-CDC42 at the membrane recruiting the complex from the cytoplasm to promote activation of neighbouring CDC42. A corresponding negative feedback loop appears to ensure only one bud forms. - - - - - - - psi-mi:"MI:0469"(IntAct) P11433(1)|P29366(1)|P48562(0) +CPX-3503 MIH complex Mlc1p-Iqg1p-Hof1p complex 559292 P53141(0)|Q05080(0)|Q12280(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-20558196 GO:0005886(plasma membrane)|GO:0031991(regulation of actomyosin contractile ring contraction)|GO:0032465(regulation of cytokinesis)|GO:1903338(regulation of cell wall organization or biogenesis) complex portal:CPX-3503(complex-primary) Role in cytokinesis. May bridge actomyosin ring contraction and septum synthesis, resulting in the coordination of these processes, and leading to plasma membrane ingression and fusion. - - - - - - - psi-mi:"MI:0469"(IntAct) P53141(0)|Q05080(0)|Q12280(0) +CPX-3541 AIM21-TDA2 actin assembly regulator complex Aim21/Tda2 complex 559292 P40045(0)|P40563(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:2000813(negative regulation of barbed-end actin filament capping)|GO:0030479(actin cortical patch) complex portal:CPX-3541(complex-primary) Localizes to actin cortical patches at sites of endocytosis and negatively regulates barbed end F-actin assembly, resulting in the generation of free actin pools. Necessary for efficient endocytosis and balancing the distribution of actin between patches and cables. Interacts with, and may regulate the activity of, the F-actin capping protein complex (CPX-1637). - - - - - - - psi-mi:"MI:0469"(IntAct) P40045(0)|P40563(0) +CPX-3621 ATR-ATRIP DNA damage-sensing kinase complex MEC1-DDC2 complex 559292 P38111(2)|Q04377(2) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-20596137 GO:0004674(protein serine/threonine kinase activity)|GO:0070310(ATR-ATRIP complex)|GO:0006139(nucleobase-containing compound metabolic process)|GO:2000779(regulation of double-strand break repair)|GO:0005634(nucleus) intenz:2.7.11.1(identity)|pubmed:28036033(see-also)|wwpdb:5X6O(identity)|emdb:EMD-6708(identity)|complex portal:CPX-3621(complex-primary) Master regulator of the DNA damage response controlling a signaling cascade required for the maintenance of genomic integrity. Activated by RPA complex (CPX-21)-coated single-stranded DNA at the site of DNA double-strand breaks and stalled replication forks. Appears to control the production of an adequate and balanced pool of deoxyribonucleotides and maintain replication fork stability. The complex has a butterfly-like dimeric architecture with a two-fold rotational symmetry. Forms a dimer of heterodimers through the proline-rich doman (PRD) and FAT (IPR003152) domains of MEC1 and the coiled-coil domain of DDC2. The activation loop of MEC1 is inhibited by the PRD, suggestng an allosteric mechanism of kinase activation. - - - - - - psi-mi:"MI:0469"(IntAct) P38111(2)|Q04377(2) +CPX-3681 SCF-Ydr131c ubiquitin ligase complex - 559292 P14682(1)|P52286(1)|Q03899(1)|Q08273(1)|Q12018(1) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0019005(SCF ubiquitin ligase complex)|GO:0006511(ubiquitin-dependent protein catabolic process)|GO:0061630(ubiquitin protein ligase activity) pubmed:15571813(see-also)|pubmed:15688063(see-also)|pubmed:14747994(see-also)|pubmed:17141224(see-also)|complex portal:CPX-3681(complex-primary) SCF-Ydr131c is a member of the SCF (Skp1-Cullin-F-box) E3 ubiquitin ligase family, in which the F-box protein, YDR131C (Q03899), forms the substrate recognition subunit. The complex may form a homodimer. - Heteropentamer - - - - - psi-mi:"MI:0469"(IntAct) P14682(1)|P52286(1)|Q03899(1)|Q08273(1)|Q12018(1) +CPX-824 Nuclear pore complex Nuclear pore|NPC|yNPC 559292 P14907(0)|P20676(0)|P32499(0)|P32500(0)|P34077(0)|P35729(0)|P36161(0)|P38181(0)|P39685(0)|P39705(0)|P40064(0)|P40066(0)|P40368(0)|P40457(0)|P40477(0)|P46673(0)|P47054(0)|P48837(0)|P49686(0)|P49687-PRO_0000019927(0)|P49687-PRO_0000019928(0)|P52593(0)|P52891(0)|P53011(0)|Q02199(0)|Q02455(0)|Q02629(0)|Q02630(0)|Q02647(0)|Q03790(0)|Q04491(0)|Q05166(0)|Q12315(0)|Q12445(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0005643(nuclear pore)|GO:0005635(nuclear envelope)|GO:0006913(nucleocytoplasmic transport) emdb:EMD-7321(subset)|pubmed:11574060(see-also)|pubmed:17440484(see-also)|pubmed:29539637(see-also)|complex portal:CPX-824(complex-primary)|intact:EBI-1255825(secondary-ac)|intact:EBI-20715213(secondary-ac)|pubmed:27999437(see-also) The nuclear pore complex (NPC) is a large assembly embedded in the nuclear envelope of eukaryotic cells. The yeast nucleus contains approximately 200 NPCs per cell and as the sole site of macromolecular traffic between the nucleus and cytoplasm, the complex provides an important control point for the regulation of gene expression. Inert polymers and small proteins less than 9 nm in diameter or less than 30-40 kDa in mass can freely diffuse through the NPC, larger particles traverse the NPC by a facilitated mechanism with the structure able to expand radially to accommodate the passage of larger particles. The nuclear basket subunits play an active role in transcription, transcriptional memory and chromatin organization by recruiting members of the transcription machinery to the nuclear side of the NCP. The nuclear pore complex has a hollow cylindrical shape with eight-fold rotational symmetry along the axis perpendicular to the nuclear envelope with dimensions of 96 nm diameter by 35 nm high in yeast. The nucleoporin proteins (NUPs) assemble into several sub-complexes that form higher-order structures called spokes. Eight spokes assemble into larger modules: coaxial outer and inner rings form a symmetric core scaffold, which is connected to a membrane ring, a nuclear basket and cytoplasmic RNA export complexes. Each of the constituent proteins is present in 8-56 copies, with a total of 552 proteins in yeast. The scaffold surrounds a central channel that is formed in part by multiple intrinsically disordered Phe-Gly (FG) repeat motifs that extend from nucleoporins termed FG NUPs. These FG motifs mediate selective nucleocytoplasmic transport through specific interactions with nuclear transport factors, which carry their cognate macromolecular cargoes. There are a total of 32 repeating Y subcomplexes consisting of 7 subunits, NUP133, NUP84, NUP85, NUP120, NUP145C, SEC13 and SEH1. They are arranged in four rings of 8 subcomplexes, 2 rings each making up the main components of the nuclear and cytoplasmic rings (NR, CR). Within each CR and NR, there are 2 rings of 8, the inner and outer rings. The inner ring complex (IRC) consists at least of NUP157, NUP170, NUP188 and NUP192. Anchored to the IRC inside the pore is a FG-NUP-enriched subcomplex composed of NSP1, NIC96, NUP49 and NUP57. The inner ring harbours the central transport channel and diffusion barrier of the NPC, preventing macromolecules larger than 30-40 kDa from freely diffusing across the nuclear envelope. GLE1, GLE2, NUP42, NUP116 and subcomplex NSP1-NUP82-NUP159-DYN2 localize to the cytoplasmic side and contribute to the cytoplasmic filaments, whereas NUP1, NUP2, NUP60, MLP1 and MLP2 localize to the nuclear side and form the nuclear basket. Nup100 and NUP145N may occur on the cytoplasmic and nuclear side while NSP1 may occur on the cytoplasmic side and the inner channel. NDC1, NUP53, ASM4 (NUP59), POM34 and POM152 are transmembrane NUPs forming the membrane ring subcomplex. MW ~52MDa. - - - - - - psi-mi:"MI:0469"(IntAct) P14907(0)|P20676(0)|P32499(0)|P32500(0)|P34077(0)|P35729(0)|P36161(0)|P38181(0)|P39685(0)|P39705(0)|P40064(0)|P40066(0)|P40368(0)|P40457(0)|P40477(0)|P46673(0)|P47054(0)|P48837(0)|P49686(0)|P49687-PRO_0000019927(0)|P49687-PRO_0000019928(0)|P52593(0)|P52891(0)|P53011(0)|Q02199(0)|Q02455(0)|Q02629(0)|Q02630(0)|Q02647(0)|Q03790(0)|Q04491(0)|Q05166(0)|Q12315(0)|Q12445(0) +CPX-1839 alpha-1,6-mannosyltransferase complex, M-Pol II variant M-Pol II complex|Mannan polymerase II|Mannosyltransferase Complex M-Pol II 559292 P32629(0)|P39107(0)|P46985(0)|P47124(0)|P50108(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0000032(cell wall mannoprotein biosynthetic process)|GO:0000136(alpha-1,6-mannosyltransferase complex)|GO:0000009(alpha-1,6-mannosyltransferase activity) pubmed:10037752(see-also)|complex portal:CPX-1839(complex-primary)|intact:EBI-2625503(secondary-ac) Role in the initiation and extension of an alpha -1,6-linked polymannose backbone as a first step in mannan synthesis, a branched polymer attached to the glycans of many of the proteins destined for the cell wall. May play the major role in the the extension of the mannan backbone after it is initiated by M-Pol I (CPX-1672). - - - - - - - psi-mi:"MI:0486"(UniProt) P32629(0)|P39107(0)|P46985(0)|P47124(0)|P50108(0) +CPX-1622 ESCRT-0 complex ESCRT0 complex|Endosomal sorting complex required for transport-0 complex. 559292 P38753(0)|P40343(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-15843724 GO:0033565(ESCRT-0 complex)|GO:0043130(ubiquitin binding)|GO:0043162(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway) complex portal:CPX-1622(complex-primary)|pubmed:17450176(see-also) The ESCRT machinery consists of ESCRT-0 (this complex), -I (CPX-940), -II (CPX-1623), -III (CPX-1624) and -IV (VPS4 complex, CPX-334) and is required for the downregulation of cell-surface receptors and for the final membrane scission step during endocytosis. ESCRT-0 binds PI3P on endosomes and ubiquitinated cargo via VPS27, recruiting clathrin and sequestering ubiquitylated cargo in clathrin-coated microdomains. HSE1 recruits ESCRT-1 and initiates the multivesicular body (MVB) pathway. - - - - - - - psi-mi:"MI:0469"(IntAct) P38753(0)|P40343(0) +CPX-1623 ESCRT-II complex ESCRT II complex|ESCRT2 complex|Endosomal sorting complex required for transport-II complex.|ESCRT-2 complex 559292 P47142(2)|Q06696(1)|Q12483(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-1040027 GO:0000814(ESCRT II complex)|GO:0043162(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|GO:0043130(ubiquitin binding) complex portal:CPX-1623(complex-primary)|pubmed:17450176(see-also)|wwpdb:1u5t(identity)|wwpdb:1W7P(identity) The ESCRT machinery consists of ESCRT-0 (CPX-1622), -I (CPX-940), -II (this complex), -III (CPX-1624) and -IV (VPS4 complex, CPX-334) and is required for the downregulation of cell-surface receptors and for the final membrane scission step during endocytosis. ESCRT-II transiently associates with endosomes and facilitates recruitment of ESCRT-III components to membranes. The core of ESCRT-II is a flat Y-shaped heterotetramer with one copy each of SNF8 and VPS36 forming the base of the Y and two copies of VPS25 forming the arms. VPS36 interacts with both phosphatidylinositol 3-phosphate, ubiquitin and the VPS28 subunit from ESCRT-I (CPX-940). VPS25 interacts with the VPS20 subunit (Q04272) of ECSRT-III (CPX-1624). Heterotetramer - - - - - psi-mi:"MI:0469"(IntAct) P47142(2)|Q06696(1)|Q12483(1) +CPX-1624 ESCRT-III complex ESCRT III complex|ESCRT3 complex|Endosomal sorting complex required for transport-III complex|ESCRT-3 complex 559292 P36095(0)|P36108(0)|P39929(0)|Q04272(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0000815(ESCRT III complex)|GO:0043162(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway) complex portal:CPX-1624(complex-primary)|pubmed:17450176(see-also) A membrane fission complex that is part of the ESCRT machinery of ESCRT-0 (CPX-1622), -I (CPX-940), -II (CPX-1623), -III (this complex) and -IV (VPS4 complex, CPX-334). It is involved in multiple membrane fission processes: a) the final step of cell organelle fusion processes such as the biogenesis of intraluminal vesicles (ILV) in multivesicular bodies (MVB, a type of late endosomes), fusion of autophagosomes with MVB or lysosomes and amphisomes or MVB with lysosomes, thereby playing a crucial role in processes like autophagy and downregulation of cell-surface receptors, b) polarity, c) migration, d) miRNA activity, e) mRNA transport, f) repair of plasma membrane wounds, g) the final scission of cytokineses, h) nuclear envelope sealing by annular fusion, i) nuclear pore complex (NPC) surveillance and j) extraction of defective NPCs. ESCRT-III assembles into a highly ordered filament-like hetero-oligomer, which may spatially restrict membrane-curvature-inducing factors to initiate budding away from the cytoplasm. VPS20 nucleates the homo-oligomerization of SNF7 that is capped by VPS24. VPS24 recruits VPS2, initiates VPS4-dependent ESCRT-III dissasembly and binds phosphatidylinositol 3,5-diphosphate. All four ESCRT-III subunits are predicted to share a common domain architecture of four α helices bundled into an N-terminal core domain, followed by an unstructured C-terminal region. The complex architecture relies primarily interactions between its subunits and the endosome. SNF7, VPS24, and VPS2 coassemble into membrane-deforming helices by directly modulating the three-dimensional architecture of SNF7 filaments. - - - - - - psi-mi:"MI:0469"(IntAct) P36095(0)|P36108(0)|P39929(0)|Q04272(0) +CPX-1625 HOPS complex Homotypic fusion and vacuole protein sorting complex|class C vacuolar protein sorting complex|Vps complex|vacuolar assembly complex 559292 P12868(0)|P20795(0)|P27801(0)|P38959(0)|Q03308(0)|Q07468(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-618548 GO:0042144(vacuole fusion, non-autophagic)|GO:0030897(HOPS complex)|GO:0099022(vesicle tethering) complex portal:CPX-1625(complex-primary)|pubmed:19272020(see-also)|pubmed:20521906(see-also) Controls homotypic vacuole-vacuole fusion by regulating vesicle docking to the vacuole through its interaction with soluble SNAREs (CPX-1887), the GTP-bound form of the Rab protein Ypt7 (P32939) and phosphoinositides. HOPS indirectly facilitates trans-SNARE complex formation by tethering membranes then protects newly formed trans-SNARE complexes from disassembly by Sec17/Sec18. Reduces the levels of noncanonical trans-SNARE complexes formed during fusion, and further reduces the capacity of these mismatched complexes to undergo fusion. HOPS function is regulated through phosphorylation of its Vps41 subunit by Yck3 which lowers its affinity for vacuolar lipids. - - - - - - - psi-mi:"MI:0469"(IntAct) P12868(0)|P20795(0)|P27801(0)|P38959(0)|Q03308(0)|Q07468(0) +CPX-1626 CORVET complex Class C core vacuole/endosome tethering complex. 559292 P12868(0)|P20795(0)|P23643(0)|P27801(0)|P39702(0)|Q03308(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0033263(CORVET complex)|GO:0032889(regulation of vacuole fusion, non-autophagic)|GO:0099022(vesicle tethering)|GO:0031901(early endosome membrane) complex portal:CPX-1626(complex-primary)|pubmed:19272020(see-also) Early endosomal tethering complex which cooperates with Rab GTPases to capture vesicles and trap them prior to the action of SNAREs. Catalyses either vacuole fission into sub-compartments or vacuole-endosome fusion, or both, by interacting with the Rab GTPase Vps21 to promote tethering and fusion of Rab5/Vps21-positive membranes. Molecular weight 700kDa - - - - - - psi-mi:"MI:0469"(IntAct) P12868(0)|P20795(0)|P23643(0)|P27801(0)|P39702(0)|Q03308(0) +CPX-1627 RAVE complex Regulator of the H+-ATPase of vacuolar and endosomal membranes complex. 559292 P47104(0)|P52286(0)|Q03956(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-782900 GO:0070072(vacuolar proton-transporting V-type ATPase complex assembly)|GO:0012505(endomembrane system)|GO:0043291(RAVE complex) complex portal:CPX-1627(complex-primary)|pubmed:17623654(see-also) Mediates both the biosynthetic assembly and the glucose-induced reassembly of the V-ATPase (CPX-1193). Binds to V1 released from the vacuolar membrane by glucose deprivation and releases V1 upon glucose readdition. Appears to be aiding cytosolic V1 complexes to assemble with V0 at the membrane. - - - - - - - psi-mi:"MI:0469"(IntAct) P47104(0)|P52286(0)|Q03956(0) +CPX-1628 Decapping complex, DCP1-DCP2 Dcp1p/Dcp2p complex|m7GpppN-mRNA hydrolase complex 559292 P53550(0)|Q12517(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-390213 GO:0098745(Dcp1-Dcp2 complex)|GO:0050072(m7G(5')pppN diphosphatase activity)|GO:0003729(mRNA binding)|GO:0000290(deadenylation-dependent decapping of nuclear-transcribed mRNA)|GO:0031087(deadenylation-independent decapping of nuclear-transcribed mRNA)|GO:0000184(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay) complex portal:CPX-1628(complex-primary)|pubmed:12554866(see-also)|pubmed:15225542(see-also)|intenz:3.6.1.62(identity) Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. The DCP1-DCP2 complex appears to contains an additional RNA-binding site spatially distinct from the DCP2 active site. - - - - - - - psi-mi:"MI:0469"(IntAct) P53550(0)|Q12517(0) +CPX-1629 TIM22 mitochondrial inner membrane twin-pore carrier translocase complex Mitochondrial import inner membrane translocase|TIM22 complex 559292 O74700(3)|P32830(0)|P47045(0)|P87108(3)|Q08749(0)|Q12328(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-1212780 GO:0045039(protein import into mitochondrial inner membrane)|GO:0042721(TIM22 mitochondrial import inner membrane insertion complex)|GO:0031305(integral component of mitochondrial inner membrane) complex portal:CPX-1629(complex-primary)|pubmed:10648604(see-also) Mediates the insertion and lateral release of multi-spanning membrane precursor proteins into the mitochondrial inner membrane in a membrane potential-dependent manner following translocation into the mitochondrion. Most mitochondrial proteins are synthesized in the cytosol, imported into mitochondria, sorted to one of the four submitochondrial compartments, where they function, and attain their functional native conformation, which is often facilitated by assembly into the membrane or a multiprotein complex. TIM22 forms an insertion channel which probably accommodates loop structures of transmembrane segments of substrate membrane proteins. TIM54 is required for assembly and stability of the complex. TIM12 provides an interaction site for a portion of the TIM9-TIM10 complex (CPX-2268) at the inner membrane. M. W. = 300 kDA. - - - - - - psi-mi:"MI:0469"(IntAct) O74700(3)|P32830(0)|P47045(0)|P87108(3)|Q08749(0)|Q12328(0) +CPX-1630 Mitochondrial processing peptidase complex MAS1-Mas2 heterodimer|MPP complex 559292 CHEBI:29105(1)|P10507(1)|P11914(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-1031572 GO:0017087(mitochondrial processing peptidase complex)|GO:0005739(mitochondrion)|GO:0004222(metalloendopeptidase activity)|GO:0006627(protein processing involved in protein targeting to mitochondrion) complex portal:CPX-1630(complex-primary)|wwpdb:1HR6(identity)|intenz:3.4.24.64(identity)|wwpdb:1HR7(identity)|wwpdb:1HR9(identity) Metalloprotease which cleaves off the N-terminal presequence from nuclear encoded mitochondrial precursor proteins, such as the sequence that targets the proteins to the mitochondrial matrix. Common features for cleavage of the extension peptides by MPP are a proximal basic amino acid residue, usually arginine at the P2 position, distal N-terminal basic residues generally 3-10 residues from the proximal arginine and an aromatic or less often another type of bulky hydrophobic residue at position P1'; MPP also prefers polar residues such as histidine, serine, and threonine at positions P2' and P3'. M.W.=100 kDa. Heterodimer - - - - - psi-mi:"MI:0469"(IntAct) P10507(1)|P11914(1) +CPX-1631 tRNA (adenine(58)-N(1))-methyltransferase complex tRNA (adenine-N(1)-)-methyltransferase|tRNA(m1A58)MTase|gcd10p-gcd14p complex|tRNA (m1A58) methyltransferase complex 559292 P41814(2)|P46959(2) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-934090 GO:0031515(tRNA (m1A) methyltransferase complex)|GO:0005634(nucleus)|GO:0016429(tRNA (adenine-N1-)-methyltransferase activity)|GO:0000049(tRNA binding)|GO:0030488(tRNA methylation)|GO:1904047(S-adenosyl-L-methionine binding) complex portal:CPX-1631(complex-primary)|wwpdb:5EQJ(identity)|wwpdb:5erg(identity)|pubmed:27582183(see-also)|rhea:RHEA:43152(identity)|intenz:2.1.1.220(identity)|pubmed:17932071(see-also) Catalyzes the transfer of a methyl group from the cofactor S-adenosyl-l-methionine (CHEBI:67040) to N1 of adenine 58 to give 1-methyladenosine (m1A58) in initiator methionyl-tRNA. This is required for maintaining the stability of the initiator methionine tRNAiMet. Two TRM6-TRM61 heterodimers assemble as a heterotetramer with TRM6 cooperating with TRM61 to form an L-shaped tRNA binding regions. Homotetramer - - - - - psi-mi:"MI:0469"(IntAct) P41814(2)|P46959(2) +CPX-1632 tRNA (guanine-N(7)-)-methyltransferase Methylation Complex TRM8-TRM81|Trm8-Trm81 complex|tRNA(m7G46)-methyltransferase 559292 Q03774(1)|Q12009(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-799824 GO:0043527(tRNA methyltransferase complex)|GO:0030488(tRNA methylation)|GO:0008176(tRNA (guanine-N7-)-methyltransferase activity)|GO:0000049(tRNA binding)|GO:1904047(S-adenosyl-L-methionine binding) complex portal:CPX-1632(complex-primary)|pubmed:18184583(see-also)|wwpdb:2VDU(identity)|intenz:2.1.1.33(identity) Required for 7-methylguanosine modification (m7G46) of tRNA. The m7G46 modification is required to prevent tRNA levels decay in a rapid tRNA degradation pathway. - Heterodimer - - - - - psi-mi:"MI:0469"(IntAct) Q03774(1)|Q12009(1) +CPX-1633 Transcription factor TFIIA complex Transcription initiation factor IIA complex|TFIIA 559292 P32773(1)|P32774(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-796683 GO:0045944(positive regulation of transcription from RNA polymerase II promoter)|GO:0060261(positive regulation of transcription initiation from RNA polymerase II promoter)|GO:0000978(RNA polymerase II core promoter proximal region sequence-specific DNA binding)|GO:0005634(nucleus)|GO:0051123(RNA polymerase II transcriptional preinitiation complex assembly)|GO:0005672(transcription factor TFIIA complex) complex portal:CPX-1633(complex-primary)|pubmed:17560669(see-also) Transcription factor complex that regulates transcription initiation from RNA polymerase II promoters. Binding to the transcription factor complex TFIID-TBP enhances assembly of the transcriptional preinitiation complex PIC and its binding to the DNA at the TATA-box by displacing transcription inhibitors. The large subunit, TOA1, interacts with DNA. Heterodimer - - - - - psi-mi:"MI:0469"(IntAct) P32773(1)|P32774(1) +CPX-1634 Protein farnesyltransferase complex FNTA-FNTB heterodimer|CAAX farnesyltransferase complex|FTase|farnesyl-diphosphate:protein-cysteine farnesyltransferase|FNTA-FNTB complex|RAM1-RAM2 complex|RAM1-RAM2 heterodimer 559292 CHEBI:29105(1)|P22007(1)|P29703(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-391110 GO:0004660(protein farnesyltransferase activity)|GO:0018343(protein farnesylation)|GO:0005965(protein farnesyltransferase complex) complex portal:CPX-1634(complex-primary)|intenz:2.5.1.58(identity) Catalyzes the transfer of a 15-carbon lipid, the farnesyl moiety, from farnesyl pyrophosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X (CaaX box). The hydrophobic farnesyl moiety aids membrane attachment of the target proteins which include many essential signal transduction proteins, including members of the Ras superfamily. Farnesylation is essential both for normal functioning of these proteins, and for the transforming activity of oncogenic mutants. Consists of an alpha subunit is thought to participate in a stable complex with the substrate and a beta subunit that binds the peptide substrate and a zinc ion. A Mg2+ ion is also required for its activity. Heterodimer - - - - - psi-mi:"MI:0469"(IntAct) P22007(1)|P29703(1) +CPX-1635 Protein geranylgeranyltransferase type I complex GGTase-I complex|GGTaseI complex|PGGT complex|PGGTase-I complex|RAS proteins geranylgeranyltransferase complex|Type-1 protein geranylgeranyltransferase complex|Type I protein geranylgeranyltransferase complex|Type I protein geranyl-geranyltransferase complex|FNTA-PGGT1B complex|FNTA-PGGT1B heterodimer 559292 CHEBI:29105(1)|P18898(1)|P29703(1) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0004662(CAAX-protein geranylgeranyltransferase activity)|GO:0005953(CAAX-protein geranylgeranyltransferase complex)|GO:0018344(protein geranylgeranylation) complex portal:CPX-1635(complex-primary)|intenz:2.5.1.59(identity)|pubmed:8756702(see-also) Catalyzes the transfer of a 20-carbon lipid, the geranyl-geranyl moiety, from geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X (CaaX box). The Zn2+ is required for peptide, but not for isoprenoid, substrate binding. The hydrophobic geranyl-geranyl moiety aids membrane attachment of the target proteins which include many essential signal transduction proteins, including members of the Ras superfamily. Consists of an alpha subunit thought to participate in a stable complex with the substrate and a beta subunit that binds the peptide substrate and a zinc ion. Heterodimer - - - - - psi-mi:"MI:0469"(IntAct) P18898(1)|P29703(1) +CPX-1636 Protein geranylgeranyltransferase type II complex Geranylgeranyl transferase type-2 complex|Geranylgeranyl transferase type II complex|GGTase-II complex|GGTaseII complex|PGGT complex|PGGTase-II complex|RAS proteins geranylgeranyltransferase complex|Type II protein geranyl-geranyltransferase complex|YPT1/SEC4 proteins geranylgeranyltransferase complex|Rab-protein geranylgeranyltransferase complex|BET2-BET4 complex|BET2-BET4 heterodimer|Type 2 protein geranyl-geranyltransferase complex|component B complex 559292 CHEBI:29105(1)|P20133(1)|P32864(0)|Q00618(1) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0005968(Rab-protein geranylgeranyltransferase complex)|GO:0018344(protein geranylgeranylation)|GO:0004663(Rab geranylgeranyltransferase activity) complex portal:CPX-1636(complex-primary)|pubmed:8756702(see-also)|intenz:2.5.1.60(identity) Catalyzes the transfer of a 20-hydrocarbon geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to a Rab protein having the C-terminal sequence -XXCC, -XCXC and -CCXX , where both cysteines may become modified. Requires both Zn2+ and Mg2+ for maximal activity. The Rab escort protein, MRS6, is the substrate-binding subunit (component A) of the complex which binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. Component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. GGTase II is a multisubunit enzyme that consists of two separate components: a catalytic component (component B) and an accessory subunit (component A). Heterodimer - - - - - psi-mi:"MI:0469"(IntAct) P20133(1)|P32864(0)|Q00618(1) +CPX-1637 F-actin capping protein complex CP|Capping protein complex 559292 P13517(1)|P28495(1) ECO:0000353(physical interaction evidence used in manual assertion) - GO:0051015(actin filament binding)|GO:0008290(F-actin capping protein complex)|GO:0051016(barbed-end actin filament capping)|GO:0015629(actin cytoskeleton) complex portal:CPX-1637(complex-primary)|intact:EBI-392910(identity)|pubmed:14769858(see-also) Caps the barbed end of the actin filament thereby blocking the exchange of subunits at these ends. The complex is an essential component for the reconstitution of movement powered by actin polymerization and is important for actin assembly and cell motility. - Heterodimer - - - - - psi-mi:"MI:0469"(IntAct) P13517(1)|P28495(1) +CPX-1638 Oligosaccharyl transferase complex variant 1 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase|Oligosaccharyltransferase complex|OST complex|OT complex|OST-6 complex 559292 P33767(1)|P39007(1)|P41543(1)|P46964(1)|Q02795(1)|Q03723(1)|Q92316(1)|Q99380(1) ECO:0005546(biological system reconstruction evidence based on paralogy evidence used in manual assertion) - GO:0004579(dolichyl-diphosphooligosaccharide-protein glycotransferase activity)|GO:0030176(integral component of endoplasmic reticulum membrane)|GO:0006487(protein N-linked glycosylation)|GO:0008250(oligosaccharyltransferase complex) pubmed:29301962(see-also)|complex portal:CPX-1638(complex-primary)|complex portal:CPX-1639(inferred-from)|pubmed:16297388(see-also)|pubmed:16317064(see-also)|intenz:2.4.99.18(identity) Transfers the dolicholphosphate-linked core oligosaccharide to selected Asn-X-Ser/Thr sequences of the nascent polypeptide chain, a key step in N-glycosylation of secretory and membrane-bound proteins in the lumen of the endoplasmic reticulum. The two variant complexes may be involved in the recognition of different protein substrates, perhaps in combination with their recruitment to the two different protein translocation machineries. Variant 1 may be involved in N-glycosylation of a group of proteins, necessary for cell wall formation or for growth at high temperature and binds to the Ssh1 translocon complex (CPX-1834). The membrane-embedded part of the OST complex contains a total of 28 trans-membrane helices, with each subunit contributing at least one trans-membrane segment. The STT3 subunit contains the active site and the acceptor peptide and donor oligosaccharide binding pockets. Heterooctomer - - - - - psi-mi:"MI:0469"(IntAct) P33767(1)|P39007(1)|P41543(1)|P46964(1)|Q02795(1)|Q03723(1)|Q92316(1)|Q99380(1) +CPX-1639 Oligosaccharyl transferase complex variant 2 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase|Oligosaccharyltransferase complex|OST complex|OT complex|OST-3 complex 559292 P33767(1)|P39007(1)|P41543(1)|P46964(1)|P48439(1)|Q02795(1)|Q92316(1)|Q99380(1) ECO:0000353(physical interaction evidence used in manual assertion) wwpdb:6ezn GO:0004579(dolichyl-diphosphooligosaccharide-protein glycotransferase activity)|GO:0006487(protein N-linked glycosylation)|GO:0008250(oligosaccharyltransferase complex)|GO:0030176(integral component of endoplasmic reticulum membrane) emdb:4161(identity)|pubmed:29301962(see-also)|complex portal:CPX-1639(complex-primary)|pubmed:16297388(see-also)|pubmed:16317064(see-also)|intenz:2.4.99.18(identity) Transfers the dolicholphosphate-linked core oligosaccharide to selected Asn-X-Ser/Thr sequences of the nascent polypeptide chain, a key step in N-glycosylation of secretory and membrane-bound proteins in the lumen of the endoplasmic reticulum. The two variant complexes may be involved in the recognition of different protein substrates, perhaps in combination with their recruitment to the two different protein translocation machineries. Variant 2 binds to SEC61 translocon complex (CPX-1833). The membrane-embedded part of the OST complex contains a total of 28 trans-membrane helices, with each subunit contributing at least one trans-membrane segment. The STT3 subunit contains the active site and the acceptor peptide and donor oligosaccharide binding pockets. Hetrooctamer - - - - - psi-mi:"MI:0469"(IntAct) P33767(1)|P39007(1)|P41543(1)|P46964(1)|P48439(1)|Q02795(1)|Q92316(1)|Q99380(1) +CPX-1640 Nucleotide excision repair factor 2 complex NEF2 complex|rad4-rad23 complex|Rad4/Rad23 complex|Rad23/Rad4 complex 559292 P14736(1)|P32628(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-391083 GO:0000111(nucleotide-excision repair factor 2 complex)|GO:0003684(damaged DNA binding)|GO:0000715(nucleotide-excision repair, DNA damage recognition) wwpdb:2qsf(identity)|complex portal:CPX-1640(complex-primary)|wwpdb:2qsh(identity)|wwpdb:2qst(identity)|wwpdb:2qsg(identity)|pubmed:10915862(see-also) Nucleotide excision repair damage-recognition heterodimer. Binds damaged DNA and recruits the NEF1 and NEF3 complexes. Rad4 inserts a beta-hairpin through the DNA duplex, causing the two damaged base pairs to flip out of the double helix. Lesion recognition does not appear to be based in structural discrimination between normal and damaged DNA by Rad4/XPC, but may be due to a ‘kinetic gating’ mechanism, whereby the DNA lesion selectivity arises mainly from the kinetic competition between Rad4-induced DNA opening and the residence time of Rad4 at a given site. - - - - - - - psi-mi:"MI:0469"(IntAct) P14736(1)|P32628(1) +CPX-1641 GINS complex Go, Ichi, Ni and San complex 559292 P40359(1)|Q03406(1)|Q12146(1)|Q12488(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-853295 GO:0006268(DNA unwinding involved in DNA replication)|GO:1900264(positive regulation of DNA-directed DNA polymerase activity)|GO:1903934(positive regulation of DNA primase activity)|GO:0000811(GINS complex)|GO:0003697(single-stranded DNA binding)|GO:0005634(nucleus) complex portal:CPX-1641(complex-primary)|pubmed:16714283(see-also) Required for the initiation of replication and for replication fork progression, mediating interactions with replication factors. Binds to and enhances the enzymatic function of the MCM helicase (CPX-2944) during the initiation and elongation stages of replication. Core component of the replicative helicase CMG (CPX-297) complex that serves as the replicative helicase unwinding duplex DNA ahead of moving replication fork during chromosome duplication. Also appears to interact with and stimulate the polymerase activities of DNA polymerase epsilon complex (CPX-2110) and the DNA polymerase alpha:primase complex (CPX-2091). - Heterotetramer - - - - - psi-mi:"MI:0469"(IntAct) P40359(1)|Q03406(1)|Q12146(1)|Q12488(1) +CPX-1642 General transcription factor complex TFIID Transcription factor complex IID 559292 P11747(1)|P13393(1)|P23255(1)|P35189(3)|P38129(2)|P46677(1)|P50105(2)|P53040(2)|Q03750(1)|Q03761(2)|Q04226(1)|Q05021(1)|Q05027(2)|Q12030(2)|Q12297(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-73627 GO:0001046(core promoter sequence-specific DNA binding)|GO:0005669(transcription factor TFIID complex)|GO:0045944(positive regulation of transcription by RNA polymerase II)|GO:0005634(nucleus) complex portal:CPX-1642(complex-primary)|wwpdb:4oy2(subset)|pubmed:12093743(see-also) General transcription factor complex that acts as the primary core promoter recognition factor in the initiation of RNA polymerase II (Pol II)-dependent transcription. The TBP subunit of TFIID recognizes and binds to the TATA box (if present), while TAF1 and TAF2 interact with the Initiator element (Inr), and TAF1 and the TAF6-TAF9 module recognizes the downstream core promoter element (DPE). Other core promoter elements, such as the motif ten element (MTE), may also be involved. Binding of the general transcription factor complex TFIIA (CPX-1633) enhances binding of TFIID to the core promoter and nucleates pre-initiation complex (PIC) assembly. Following recruitment of TFIIA to TFIID, TFIIB, TFIIF, Pol II, TFIIE (CPX-1658) and TFIIH are successively assembled at the core promoter, allowing the PIC to initiate Pol II transcription. Resembles a molecular clamp formed by three major lobes connected by thin linking domains. Nine TATA box-binding protein-associated factors that contain the histone fold structural motif were located in three distinct substructures of TFIID. Hetero-23-mer - - - - - psi-mi:"MI:0469"(IntAct) P11747(1)|P13393(1)|P23255(1)|P35189(3)|P38129(2)|P46677(1)|P50105(2)|P53040(2)|Q03750(1)|Q03761(2)|Q04226(1)|Q05021(1)|Q05027(2)|Q12030(2)|Q12297(1) +CPX-1643 UDP-N-acetylglucosamine transferase complex - 559292 P38242(1)|P53178(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-989509 GO:0006488(dolichol-linked oligosaccharide biosynthetic process)|GO:0042406(extrinsic component of endoplasmic reticulum membrane)|GO:0043541(UDP-N-acetylglucosamine transferase complex)|GO:0004577(N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity) complex portal:CPX-1643(complex-primary)|intenz:2.4.1.141(identity)|pubmed:16100110(see-also) Catalyses the second step of eukaryotic N-linked glycosylation in endoplasmic reticulum, transferring an N-acetylglucosamine (GlcNAc) from UDP-GlcNAc to GlcNAc-PP-Dolichol. Alg14 is a membrane protein that recruits the cytosolic Alg13 protein to the ER, Alg13 contains the catalytic domain of the UDP-GlcNAc transferase, but cytosolic Alg13 is not active unless bound to Alg14 at the ER membrane suggesting the formation of the Alg13/14 complex is crucial for UDP-GlcNAc transferase activity. - Heterodimer - - - - - psi-mi:"MI:0469"(IntAct) P38242(1)|P53178(1) +CPX-1644 HOP2-MND1 complex HOP2/MND1 complex|H2M1 complex 559292 P53102(1)|P53187(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-996131 GO:0000794(condensed nuclear chromosome)|GO:0003690(double-stranded DNA binding)|GO:0000794(condensed nuclear chromosome)|GO:0007131(reciprocal meiotic recombination)|GO:0007129(homologous chromosome pairing at meiosis) complex portal:CPX-1644(complex-primary)|pubmed:16675459(see-also) Recombinase cofactor that activates both RAD51 (P25454)- and DMC1 (P25453)-mediated homologous pairing during homologous recombination. Acts to stabilize the presynaptic filament, a right-handed helical nucleoprotein strand generated by RAD51 and DMC1 from single-stranded DNA derived from the nucleolytic processing of a primary lesion. The HOP2-MND1 complex synergizes with the filament to assemble the synaptic complex, and promotes DMC1-/RAD51-mediated strand exchange between the presynaptic filament and recombining double-stranded DNA to form a D-loop, acting with RAD54 (P32863), a nucleosome remodeler, to promote homologous pairing with the nucleosomal double-stranded DNA.. - Heterodimer - - - - - psi-mi:"MI:0469"(IntAct) P53102(1)|P53187(1) +CPX-1645 Ste4-Ste18 heterodimer G protein beta-gamma dimer|St4-St18 dimer|beta-gamma heterodimer|G protein beta-gamma heterodimer|G beta-gamma|GBB-GBG complex 559292 P18851(1)|P18852(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-1565320 GO:0000750(pheromone-dependent signal transduction involved in conjugation with cellular fusion)|GO:0005886(plasma membrane)|GO:0031680(G-protein beta/gamma-subunit complex) complex portal:CPX-1645(complex-primary)|pubmed:17138892(see-also) Signal-transmitting component of the G protein heterotrimer in the pheremone response pathway. Activation of the Ste2 receptor by mating pheromone leads to GTP binding and dissociation of the G protein alpha subunit (Gpa1, P08539) from the G protein beta and gamma subunit complex (STE4 and STW18). STE4-STE18 activate the downstream pheromone signaling MAP kinase cascade leading to expression of mating-specific genes, inducing cell cycle arrest in G1, promoting polarized cell growth to form mating projections (shmoos), and establishing the changes in plasma membrane, cell wall and nuclear envelope to permit cell-cell fusion (plasmogamy) and fusion of the two haploid nuclei (karyogamy). - Heterodimer - - - - - psi-mi:"MI:0469"(IntAct) P18851(1)|P18852(1) +CPX-1646 G protein heterotrimer GPA1-GBB-GBG complex|G protein|Guanine nucleotide-binding protein 559292 P08539(1)|P18851(1)|P18852(1) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0005834(heterotrimeric G-protein complex)|GO:0000750(pheromone-dependent signal transduction involved in conjugation with cellular fusion)|GO:0005525(GTP binding)|GO:0019003(GDP binding) complex portal:CPX-1646(complex-primary)|pubmed:17138892(see-also) Inactive form of the G protein signal-transmitting component in the pheremone response pathway. Activation of the Ste2 receptor by mating pheromone leads to GTP binding and dissociation of the G protein alpha subunit (GPA1) from the G protein beta and gamma subunits (CPX-1645). - Heterotrimer - - - - - psi-mi:"MI:0469"(IntAct) P08539(1)|P18851(1)|P18852(1) +CPX-1647 SF3B complex - 559292 P0C074(0)|P49955(0)|Q02554(0)|Q04693(0)|Q06835(0)|Q99181(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-464861 GO:0030620(U2 snRNA binding)|GO:0005684(U2-type spliceosomal complex)|GO:0000398(mRNA splicing, via spliceosome) complex portal:CPX-1647(complex-primary) Spliceosomal complex, an essential factor for splicing of pre-mRNA. Part of the U2 snRNP as well as the U11/U12 di-snRNP. Present in the pre-spliceosomal A complex and the fully assembled catalytic active spliceosomes. - - - - - - - psi-mi:"MI:0469"(IntAct) P0C074(0)|P49955(0)|Q02554(0)|Q04693(0)|Q06835(0)|Q99181(0) +CPX-1648 SF3A complex - 559292 P19736(1)|P32524(1)|Q07350(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-11413487 GO:0030620(U2 snRNA binding)|GO:0071004(U2-type prespliceosome)|GO:0000398(mRNA splicing, via spliceosome) complex portal:CPX-1648(complex-primary)|wwpdb:4dgw(identity) Essential role in pre-mRNA splicing. A core component of the mature U2 snRNP (small nuclear ribonucleoprotein particle), a dynamic 17S particle which assembles as part of the spliceosome. Displacement of SF3A from the spliceosome initiates the first step of the splicing reaction. Structural studies suggest a bifurcated assembly of the three subunits, with Prp9 interacting with Prp21 via a bidentate-binding mode, and Prp21 wrapping around Prp11. Prp9 contains a major binding site for stem-loop IIa of U2 snRNA. Heterotrimer - - - - - psi-mi:"MI:0469"(IntAct) P19736(1)|P32524(1)|Q07350(1) +CPX-1649 RES complex pre mRNA retention and splicing RES complex|pre mRNA retention and splicing complex 559292 P40565(0)|P46947(0)|Q07930(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-464870 GO:0070274(RES complex)|GO:0036002(pre-mRNA binding)|GO:0051237(maintenance of RNA location) complex portal:CPX-1649(complex-primary)|pubmed:25218446(see-also)|wwpdb:2mkc(identity)|pubmed:29330354(see-also)|pubmed:15565172(see-also) Required for efficient splicing as well as nuclear retention of pre-mRNA.Promotes the efficient formation of the activated Bact spliceosomal complex from the U4/U6.U5 tri-snRNP (CPX-25). - - - - - - - psi-mi:"MI:0469"(IntAct) P40565(0)|P46947(0)|Q07930(0) +CPX-1651 PRP19-associated complex CWC complex|NTC-associated complex|Nineteen-associated complex|NTC/PRP19 complex 559292 P19736(0)|P21374(0)|P24384(0)|P25337(0)|P28004(0)|P28320(0)|P32523(0)|P32524(0)|P32639(0)|P33334(0)|P36048(0)|P38241(0)|P38302(0)|P40018(0)|P40565(0)|P40567(0)|P40968(0)|P43321(0)|P46947(0)|P49955(0)|P52868(0)|P53277(0)|P53333(0)|P53769(0)|P53854(0)|P54999(0)|Q02260(0)|Q02521(0)|Q02554(0)|Q02770(0)|Q02775(0)|Q03375(0)|Q03654(0)|Q03772(0)|Q04048(0)|Q04693(0)|Q06091(0)|Q06217(0)|Q07350(0)|Q08963(0)|Q12046(0)|Q12309(0)|Q12417(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-538568 GO:0000398(mRNA splicing, via spliceosome)|GO:0000974(Prp19 complex) complex portal:CPX-1651(complex-primary)|pubmed:23742842(see-also) Required for defining the specificity of interaction of the U5 and U6 small nuclear ribonucleoprotein particles with the 5' splice site to stabilize their association with the spliceosome after U4 is dissociated. - - - - - - - psi-mi:"MI:0469"(IntAct) P19736(0)|P21374(0)|P24384(0)|P25337(0)|P28004(0)|P28320(0)|P32523(0)|P32524(0)|P32639(0)|P33334(0)|P36048(0)|P38241(0)|P38302(0)|P40018(0)|P40565(0)|P40567(0)|P40968(0)|P43321(0)|P46947(0)|P49955(0)|P52868(0)|P53277(0)|P53333(0)|P53769(0)|P53854(0)|P54999(0)|Q02260(0)|Q02521(0)|Q02554(0)|Q02770(0)|Q02775(0)|Q03375(0)|Q03654(0)|Q03772(0)|Q04048(0)|Q04693(0)|Q06091(0)|Q06217(0)|Q07350(0)|Q08963(0)|Q12046(0)|Q12309(0)|Q12417(0) +CPX-1652 COPI vesicle coat complex Coatomer complex|COG complex|Conserved oligomeric Golgi complex|Golgi transport complex|COPA-COPB-COPB2-COPD-COPE-COPG-COPZ 559292 P32074(0)|P40509(0)|P41810(0)|P41811(0)|P43621(0)|P53600(0)|P53622(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-807258 GO:0006890(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|GO:0005198(structural molecule activity)|GO:0030126(COPI vesicle coat) complex portal:CPX-1652(complex-primary) Coats vesicles which bud from the Golgi membrane and subsequently transport proteins from the cis end of the Golgi complex back to the rough endoplasmic reticulum (ER), where they were originally synthesized (retrograde transport), and between Golgi compartments. The complex binds to di-lysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi to the trans Golgi network. Cargo containing the sorting motifs KKXX and KXKXX interact with COPI to form carriers. - - - - - - - psi-mi:"MI:0469"(IntAct) P32074(0)|P40509(0)|P41810(0)|P41811(0)|P43621(0)|P53600(0)|P53622(0) +CPX-1653 Retromer complex - 559292 P32913(0)|P34110(0)|P38759(0)|P40335(0)|Q92331(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0030904(retromer complex)|GO:0042147(retrograde transport, endosome to Golgi)|GO:0045053(protein retention in Golgi apparatus) complex portal:CPX-1653(complex-primary)|pubmed:28757549(see-also)|pubmed:15078902(see-also) Functions in endosomal membrane protein sorting and transport for endosome-to-Golgi retrieval. Involved in the retrieval of a vacuolar protein sorting VPS10 (P32319) protein, from endosome for retrograde transport to the trans-Golgi network. VPS26-VPS35-VPS29 form a cargo sorting trimer on the endosomal membrane often referred to as cargo selective complex (CSC). VPS5 and VPS17 form a sorting nexin dimer. VPS5 and VPS17 are SNX proteins containing Bin-Amphysin-Rvs (BAR) domains for inducing membrane curvature during cargo sorting, and phox homology (PX) domains that anchor them to the endosomal membranes via strong interaction between the PX domains and the phosphatidylinositide-3-phosphates of the membrane. The CSC and the SNX subcomplexes are recruited separately, then assemble into a complex on the endosomal membranes It is not clear whether, the CSC components assembles in the cytoplasm into a trimer before its recruitment or is assembled on the membranes. - - - - - - psi-mi:"MI:0469"(IntAct) P32913(0)|P34110(0)|P38759(0)|P40335(0)|Q92331(0) +CPX-1654 m-AAA complex m-AAA protease|YTA10-12 complex 559292 CHEBI:29105(0)|P39925(0)|P40341(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-789426 GO:0005524(ATP binding)|GO:0005745(m-AAA complex)|GO:0030163(protein catabolic process)|GO:0065003(protein-containing complex assembly)|GO:0005743(mitochondrial inner membrane)|GO:0004222(metalloendopeptidase activity) complex portal:CPX-1654(complex-primary)|intenz:3.4.24(identity)|pubmed:11212342(see-also) Mitochondrial ATP-dependent protease, essential for the maintenance of cellular respiratory competence. Embedded in the inner membrane with the proteolytic domains facing the matrix. Membrane protein degradation requires the proteolytic activity of both subunits of the protease. Controls COX1 and COB pre-mRNA stability and splicing and is required for assembly of cytochrome c oxidase. MW = 1000 kDa. - - - - - - psi-mi:"MI:0469"(IntAct) P39925(0)|P40341(0) +CPX-1655 i-AAA complex i-AAA protease 559292 CHEBI:29105(0)|P25573(0)|P32795(0)|Q04472(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0004222(metalloendopeptidase activity)|GO:0045041(protein import into mitochondrial intermembrane space)|GO:0031305(integral component of mitochondrial inner membrane)|GO:0031942(i-AAA complex)|GO:0030163(protein catabolic process)|GO:0005524(ATP binding) complex portal:CPX-1655(complex-primary)|pubmed:11212342(see-also)|intenz:3.4.24(identity) Mitochondrial ATP-dependent protease, crucial for mitochondrial DNA-independent growth. Proteins residing in the IMS are transported across the outer membrane in a largely unfolded state and the complex appears to play a role as a folding assistant. MW = 1000 kDa. Embedded in the inner membrane with the proteolytic domains facing the intermembrane space. - - - - - - psi-mi:"MI:0469"(IntAct) P25573(0)|P32795(0)|Q04472(0) +CPX-1656 Transcription factor TFIIIC complex TFIIIC 559292 P32367(0)|P33339(0)|P34111(0)|Q06339(0)|Q12308(0)|Q12415(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-819961 GO:0000127(transcription factor TFIIIC complex)|GO:0003677(DNA binding)|GO:0006384(transcription initiation from RNA polymerase III promoter) wwpdb:2J04(subset)|pubmed:9418847(see-also)|complex portal:CPX-1656(complex-primary)|pubmed:26060179(see-also) Transcription factor required for Pol III transcription complex assembly. Mediates tRNA and 5S RNA gene activation by binding to intragenic promoter elements. Assembles the initiation complex TFIIIB-TFIIIC-tDNA upstream of the transcription start site, which is sufficient for RNA polymerase III (CPX-2660) recruitment and function. The six subunits are divided into two DNA-binding subcomplexes (tauA and tauB) which each bind to its respective, highly conserved promoter sequence, the A box and B box. - - - - - - psi-mi:"MI:0469"(IntAct) P32367(0)|P33339(0)|P34111(0)|Q06339(0)|Q12308(0)|Q12415(0) +CPX-1657 Nuclear cap-binding complex CBP20-CBP80 complex|CBC|Cap complex 559292 P34160(1)|Q08920(1) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0000398(mRNA splicing, via spliceosome)|GO:0005846(nuclear cap binding complex)|GO:0000956(nuclear-transcribed mRNA catabolic process)|GO:0031124(mRNA 3'-end processing)|GO:0000339(RNA cap binding)|GO:0005634(nucleus)|GO:0031053(primary miRNA processing)|GO:0042789(mRNA transcription from RNA polymerase II promoter)|GO:0006406(mRNA export from nucleus)|GO:0006970(response to osmotic stress)|GO:0000340(RNA 7-methylguanosine cap binding)|GO:0003729(mRNA binding)|GO:0005845(mRNA cap binding complex) complex portal:CPX-1657(complex-primary)|pubmed:15547136(see-also)|pubmed:24354960(see-also) Binds co-transcriptionally to the 5-prime, m7GpppG-cap (m7G-cap) structures of all RNA polymerase II transcripts (mRNAs and pre-miRNAs). Required for processes such as pre-mRNA splicing through commitment complex and spliceosome formation, export of mRNA out of the nucleus in association with NPL3 (Q01560), degradation of nuclear mRNAs, primary miRNA processing and miRNA-mediated RNA interference. In the cytosol, importin-beta interacts with CBC-bound importin-alpha (CPX-1068) and promotes the dissociation of the RNA from CBC. Importin-complex-bound CBC gets reimported into the nucleus for reuse. CBC2 directly binds the capped RNAs and STO1 is required to stabilize the movement of the N-terminal loop of CBC2 and lock the CBC into a high affinity cap-binding state with the cap structure. In contrast to metazoans, yeast cap-binding complex is not involved in the nuclear export of capped U snRNAs (PMID:15547136) nor in nonsense-mediated decay. Heterodimer - - - - - psi-mi:"MI:0469"(IntAct) P34160(1)|Q08920(1) +CPX-1658 General transcription factor complex TFIIE Transcription initiation factor IIE|General transcription factor IIE|General transcription initiation factor IIE|T2EA-T2EB complex 559292 P36100(2)|P36145(2) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-391650 GO:0005673(transcription factor TFIIE complex)|GO:0000981(DNA-binding transcription factor activity, RNA polymerase II-specific)|GO:0006367(transcription initiation from RNA polymerase II promoter)|GO:0005634(nucleus) complex portal:CPX-1658(complex-primary) Required for mRNA synthesis of many, but not all, genes in yeast. In the transcription process, TFIIE regulates TFIIH kinase activity that phosphorylates the carboxy-terminal domain of the largest subunit of RNA polymerase II. Required for the opening of DNA, to allow transcription initiation. DNA opening occurs around the tip of the Pol II clamp and the TFIIE ‘extended winged helix’ domain. TFIIF (CPX-1149) and TFIIE bind open promoter DNA from opposite sides of the Pol II cleft. TFIIF adopts an extended induced structure that allows it to retain the upstream DNA-SPT15-TFIIB assembly on the wall and to bind the DNA bubble. TFIIF and TFIIE encircle and retain the DNA and TFIIE may then act to stabilize the open DNA structure. - Heterotetramer - - - - - psi-mi:"MI:0469"(IntAct) P36100(2)|P36145(2) +CPX-1659 General transcription factor complex TFIIH TFIIK complex|Kin28p complex 559292 P06242(0)|P06839(0)|P32776(0)|P37366(0)|Q00578(0)|Q02939(0)|Q03290(0)|Q04673(0)|Q08816(0)|Q12004(0)|Q3E7C1(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-13950748 GO:0005675(holo TFIIH complex)|GO:0070816(phosphorylation of RNA polymerase II C-terminal domain)|GO:0006367(transcription initiation from RNA polymerase II promoter)|GO:0008353(RNA polymerase II carboxy-terminal domain kinase activity)|GO:0006289(nucleotide-excision repair) wwpdb:3DOM(subset)|wwpdb:3DGP(subset)|pubmed:22572993(see-also)|complex portal:CPX-1659(complex-primary)|intenz:2.7.11.23(identity) A general transcription factor which plays a central role in both RNA polymerase II transcription and DNA repair. Component of the Pol II preinitiation complex. The TFIIH subunit XPB is an ATP-dependent translocase that promotes DNA strand separation and promoter escape. During the transition from initiation to promoter clearance, the kinase subunit Kin28 phosphorylates Ser-5 and Ser-7 within the Pol II carboxyl terminal domain (CTD). This phosphorylation initiates a cascade of phosphorylation/dephosphorylation events on the CTD that correlates with dissociation of Pol II from the initiation machinery and its association with elongation and mRNA processing factors. This is the only general transcription factor with enzyme activity. During nucleotide excision repair, TFIIH is required for opening DNA around lesions that disrupt base pairing to permit excision of the damaged DNA and its replacement by a new DNA fragment. - - - - - - - psi-mi:"MI:0469"(IntAct) P06242(0)|P06839(0)|P32776(0)|P37366(0)|Q00578(0)|Q02939(0)|Q03290(0)|Q04673(0)|Q08816(0)|Q12004(0)|Q3E7C1(0) +CPX-1660 General transcription factor complex TFIIK TFIIK complex|Kin28p complex 559292 P06242(0)|P37366(0)|Q03290(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0006367(transcription initiation from RNA polymerase II promoter)|GO:0008353(RNA polymerase II carboxy-terminal domain kinase activity)|GO:0004693(cyclin-dependent protein serine/threonine kinase activity)|GO:0070985(TFIIK complex)|GO:0005524(ATP binding) complex portal:CPX-1660(complex-primary)|intenz:2.7.11.23(identity) Protein kinase component of transcription factor IIH (TFIIH) which phosphorylates the C-terminal domain of RNA polymerase II during transition from transcription to elongation after preinitiation complex (PIC) formation, thereby positively regulating transcription. TFIIH is essential for both basal and activated transcription, and is involved in nucleotide excision repair of damaged DNA. It is unclear whether this module has a role independent of that as a sub-complex of TFIIH. - - - - - - - psi-mi:"MI:0469"(IntAct) P06242(0)|P37366(0)|Q03290(0) +CPX-1661 SPT4-SPT5 transcription elongation factor complex Spt4-Spt5 heterodimer|5,6-Dichloro-1-beta-D-ribofuranosylbenzimidazole sensitivity inducing factor complex|DRB sensitivity inducing factor complex|DSIF complex|Elongation Factor Spt4/5 559292 P27692(1)|P32914(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-1372180 GO:0032044(DSIF complex)|GO:0003727(single-stranded RNA binding)|GO:0006355(regulation of transcription, DNA-templated)|GO:0005634(nucleus)|GO:0003677(DNA binding) complex portal:CPX-1661(complex-primary)|pubmed:19000817(see-also) An essential RNA polymerase II elongation factor which functions in the control of RNAP II processivity. Mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene. Binds RNA in a sequence-specific manner by recognizing multiple AA repeat sequences and a region within the conserved NusG N-terminal (NGN) domain of SPT5 contacts the non-template strand of DNA both upstream of RNAPII and in the transcription bubble. - - - - - - - psi-mi:"MI:0469"(IntAct) P27692(1)|P32914(1) +CPX-1662 Negative cofactor 2 complex NC2 complex|Negative cofactor complex 2 559292 P40096(0)|Q92317(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-1112029 GO:0017054(negative cofactor 2 complex)|GO:0000122(negative regulation of transcription from RNA polymerase II promoter)|GO:0017055(negative regulation of RNA polymerase II transcriptional preinitiation complex assembly)|GO:0000979(RNA polymerase II core promoter sequence-specific DNA binding) complex portal:CPX-1662(complex-primary) Represses RNA polymerase II transcription through binding to SPT15/TBP and thereby inhibiting the assembly of the preinitiation complex. The NC2 complex may also mediate transcriptional activation from TATA-driven promoters through association with SPT15/TBP and may form a larger, DNA-dependent, assembly with the Mot1-TBP complex (CPX-1141). - - - - - - - psi-mi:"MI:0469"(IntAct) P40096(0)|Q92317(0) +CPX-1663 CYP8-TUP1 corepressor complex Cyc8(Ssn6)-Tup1|SSN6-TUP1 complex 559292 P14922(1)|P16649(4) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-1111129 GO:0017053(transcriptional repressor complex)|GO:0000978(RNA polymerase II proximal promoter sequence-specific DNA binding)|GO:0045892(negative regulation of transcription, DNA-templated)|GO:0005634(nucleus)|GO:0006972(hyperosmotic response) complex portal:CPX-1663(complex-primary)|pubmed:7705659(see-also)|pubmed:14525981(see-also) Role in the repression of many genes in a wide variety of physiological processes including heme-regulated and catabolite repressed genes. May also be involved in the derepression of at least some target genes. The complex is recruited to target genes by interaction with DNA-bound transcriptional repressors, like MATALPHA2, MIG1, RFX1 and SKO1. The complex recruits histone deacetylases to produce a repressive chromatin structure, interacts with hypoacetylated N-terminal tails of histones H3 and H4 that have been programmed for repression by the action of histone deacetylases, and interferes directly with the transcriptional machinery by associating with the RNA polymerase II mediator complex. Undergoes transient hyperosmotic stress-induced SUMOylation and inclusion formation, which are important for the regulation of hyperosmotic-stress genes, for example the activation of glycerol biosynthesis genes. - Heteropentamer - - - - - psi-mi:"MI:0469"(IntAct) P14922(1)|P16649(4) +CPX-1664 DNA-directed RNA Polymerase I complex RNA polymerase I|Pol I|RNA polymerase A|RNA polymerase 1 559292 CHEBI:18420(1)|CHEBI:29105(2)|P07703(1)|P10964(1)|P20434(1)|P20435(1)|P20436(1)|P22138(1)|P22139(1)|P28000(1)|P32529(1)|P40422(1)|P46669(1)|P47006(1)|P50106(1)|Q01080(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-1580251 GO:0005736(DNA-directed RNA polymerase I complex)|GO:0001054(RNA polymerase I activity)|GO:0001163(RNA polymerase I transcription regulatory region sequence-specific DNA binding)|GO:0006362(transcription elongation from RNA polymerase I promoter)|GO:0042790(transcription of nuclear large rRNA transcript from RNA polymerase I promoter)|GO:0005634(nucleus)|GO:0019843(rRNA binding)|GO:0006361(transcription initiation from RNA polymerase I promoter)|GO:0006363(termination of RNA polymerase I transcription) wwpdb:4C3H(identity)|wwpdb:4c3i(identity)|wwpdb:4C3J(identity)|wwpdb:4c2m(identity)|complex portal:CPX-1664(complex-primary)|intenz:2.7.7.6(identity)|emdb:EMD-1435(identity)|wwpdb:2rf4(subset)|wwpdb:4ym7(identity) Catalyzes the transcription of RNA from a DNA template by acting as a nucleotidyl transferase that polymerizes ribonucleotides at the 3-prime end of an RNA transcript synthesizing precursors of rRNAs. Forms inactive dimers whereas initiation-competent Pol I is monomeric. Initiation of transcription requires the assembly of the upstream activating factor (UAF, CPX-1101), the core factor (CPX-1836), the TATA binding protein SPT15, and RNAP-I with RRN3 on the upstream element and core promoter. Upon transcription initiation, UAF, RRN3 and CF dissociate from the promoter. The polymerase consists of a core element with a central large cleft forming the active center. The clamp element is connected to the core through a set of flexible switches and moves to open and close the cleft. The cleft is surrounded by an upper jaw and a lower jaw. The jaws are thought to grab the incoming DNA template. The fork loop 1 interacts with the RNA-DNA hybrid, possibly stabilizing it. The active-centre cleft is expanded in comparison to Pol II (CPX-2662) and the catalytic residues in the active site at the bottom of the cleft arranged such that the enzyme is trapped in an inactive conformation. A novel protein element, the `expander', exists inside the active-centre cleft, apparently stabilizing the expanded conformation of the enzyme and occluding the template DNA-binding site. Another novel, Pol I-specific protein element, the `connector', invades the active-centre cleft of a neighbouring Pol I enzyme, leading to the formation of a tightly packed Pol I homodimer. This dimer is predicted to be transcriptionally inactive because the connector and the expander both need to be released from the polymerase to allow promoter DNA loading and RNA production. Tetradecamer - - - - - psi-mi:"MI:0469"(IntAct) P07703(1)|P10964(1)|P20434(1)|P20435(1)|P20436(1)|P22138(1)|P22139(1)|P28000(1)|P32529(1)|P40422(1)|P46669(1)|P47006(1)|P50106(1)|Q01080(1) +CPX-1665 DNA ligase IV complex Lif1-Lig4 complex 559292 P53150(2)|Q08387(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-1567355 GO:0003899(DNA-directed 5'-3' RNA polymerase activity)|GO:0032807(DNA ligase IV complex)|GO:0006303(double-strand break repair via nonhomologous end joining)|GO:0005634(nucleus) complex portal:CPX-1665(complex-primary)|intenz:6.5.1.1(identity)|wwpdb:1z56(identity) catalyses the final ligation step in the non-homologous end-joining DNA repair pathway. Ligates DNA strands to restore the continuity of the chromosome in non-homologous end joining DNA double-strand break repair. Interacts with the Ku70:Ku80 (CPX-1732) and MRX CPX-1872) complexes. Forms a twisted dumbbell. The molecular interaction between LIF1 and LIG buries 4146A2 of surface area forming a C-shaped clamp. Heterotrimer - - - - - psi-mi:"MI:0469"(IntAct) P53150(2)|Q08387(1) +CPX-1666 MutLalpha endonuclease complex MLH1-PMS1 heterodimer|MLH1/PMS1 complex 559292 P14242(1)|P38920(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-969929 GO:0004519(endonuclease activity)|GO:0032389(MutLalpha complex)|GO:0005524(ATP binding)|GO:0016887(ATPase activity)|GO:0000710(meiotic mismatch repair)|GO:0030983(mismatched DNA binding)|GO:0005634(nucleus) complex portal:CPX-1666(complex-primary)|pubmed:10570173(see-also)|wwpdb:4e4w(identity)|pubmed:23435383(see-also)|pubmed:26170454(see-also) Mn2+-dependent endonuclease which nicks a DNA strand containing a pre-existing nick, presumably to provide an entry site for a mispair excision reaction. Required for DNA mismatch repair (MMR), correcting base-base mismatches and insertion-deletion loops resulting from DNA replication, DNA damage or from recombination events between non-identical sequences during meiosis. ATP binding induces a conformational change in the MSH2-MSH6 (CPX-1037) and MSH2-MSH3 (CPX-1036) complexes which converts these to a clamp form that slides along the DNA and leads to recruitment of MutLalpha, MutLbeta (CPX-1667) and MLH1-MLH3 (CPX-1668). Plays a major role in maintaining the genetic stability of simple sequence repeats, by suppressing recombination between slightly divergent or homeologous DNA sequences, and in the repair of heteroduplex sites present in meiotic recombination intermediates. The MLH1-PMS1 heterodimer acts as the major Mlh heterodimer in MMR and is thought to coordinate Msh-DNA binding with downstream repair factors. The MLH1 and PMS1 N-terminal domains associate on binding ATP, resulting in a ring-like conformation in which the associated N-terminal domains are joined to the dimerized C-terminal domains of MLH1 and PMS1, respectively, by two unstructured linkers. The N-terminal domains then dissociate from each other upon hydrolyzing ATP, which requires a divalent cation, and ADP release. Heterodimer - - - - - psi-mi:"MI:0469"(IntAct) P14242(1)|P38920(1) +CPX-1667 MutLbeta endonuclease complex MLH1-MLH2 heterodimer|MLH1/MLH2 complex 559292 P38920(0)|Q07980(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-969909 GO:0032390(MutLbeta complex)|GO:0005634(nucleus)|GO:0000710(meiotic mismatch repair)|GO:0004519(endonuclease activity)|GO:0005524(ATP binding)|GO:0030983(mismatched DNA binding)|GO:0016887(ATPase activity) complex portal:CPX-1667(complex-primary) Mn2+-dependent endonuclease which nicks a DNA strand containing a pre-existing nick, presumably to provide an entry site for a mispair excision reaction. Required for DNA mismatch repair (MMR), correcting base-base mismatches and insertion-deletion loops resulting from DNA replication, DNA damage or from recombination events between non-identical sequences during meiosis. ATP binding induces a conformational change in the MSH2-MSH6 (CPX-1037) and MSH2-MSH3 (CPX-1036) complexes which converts these to a clamp form that slides along the DNA and leads to recruitment of MutLalpha (CPX-1666) , MutLbeta and MLH1-MLH3 (CPX-1668).. This complex has been proposed to be an accessory factor that acts in conjunction with MLH1-PMS1 (CPX-1666) in maintaining the genetic stability of simple sequence repeats, by suppressing recombination between slightly divergent or homeologous DNA sequences, and in the repair of heteroduplex sites present in meiotic recombination intermediates. It may play a role in regulating between different crossover pathways. - - - - - - - psi-mi:"MI:0469"(IntAct) P38920(0)|Q07980(0) +CPX-1668 MLH1-MLH3 endonuclease complex MutLbeta 559292 P38920(0)|Q12083(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-969919 GO:0000710(meiotic mismatch repair)|GO:0004519(endonuclease activity)|GO:0005634(nucleus)|GO:0030983(mismatched DNA binding)|GO:0097587(MutLgamma complex)|GO:0016887(ATPase activity)|GO:0005524(ATP binding) complex portal:CPX-1668(complex-primary)|pubmed:23316435(see-also) Mn2+-dependent endonuclease which nicks a DNA strand containing a pre-existing nick, presumably to provide an entry site for a mispair excision reaction. Required for DNA mismatch repair (MMR), correcting base-base mismatches and insertion-deletion loops resulting from DNA replication, DNA damage or from recombination events between non-identical sequences during meiosis. ATP binding induces a conformational change in the MSH2-MSH6 (CPX-1037) and MSH2-MSH3 (CPX-1036) complexes which converts these to a clamp form that slides along the DNA and leads to recruitment of MutLalpha (CPX-1666), MutLbeta (CPX-1667) and MLH1-MLH3. Appears to substitute in a minor way MutLalpha, for maintaining the genetic stability of simple sequence repeats, by suppressing recombination between slightly divergent or homeologous DNA sequences, and in the repair of heteroduplex sites present in meiotic recombination intermediates. - - - - - - - psi-mi:"MI:0469"(IntAct) P38920(0)|Q12083(0) +CPX-1669 RENT complex Regulator of nucleolar silencing and telophase exit 559292 P06700(0)|P47035(0)|Q00684(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-443608 GO:0000182(rDNA binding)|GO:0030869(RENT complex)|GO:0000183(chromatin silencing at rDNA)|GO:0005730(nucleolus) complex portal:CPX-1669(complex-primary) Regulates transcriptional silencing at the rDNA locus. Silencing within the yeast rDNA repeats inhibits hyperrecombination, represses transcription from foreign promoters, regulates cell cycle progression and extends replicative life span.Interaction with FOB1 is required for the association of the RENT complex with the rDNA non-transcribed spacer region and for silencing at this location. The NET1 and SIR2 subunits of RENT localize primarily to two distinct regions within rDNA: in one of the non-transcribed spacers and around the Pol I promoter, extending into the 35S rRNA coding region. - - - - - - psi-mi:"MI:0469"(IntAct) P06700(0)|P47035(0)|Q00684(0) +CPX-1670 Deoxyribonuclease complex MUS81-MMS4 MUS81-MMS4 endonuclease complex|Mms4-Mus81 endonuclease complex|Mms4/Mus81 endonuclease complex|MUS81/MMS4 endonuclease complex 559292 CHEBI:18420(3)|P38257(3)|Q04149(3) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-1567732 GO:0004520(endodeoxyribonuclease activity)|GO:0043596(nuclear replication fork)|GO:1905347(endodeoxyribonuclease complex)|GO:0007131(reciprocal meiotic recombinati)|GO:0008821(crossover junction endodeoxyri) complex portal:CPX-1670(complex-primary)|intenz:3.1.22(identity) Structure-specific endonuclease that plays an important role in rescuing stalled replication forks and resolving the mitotic recombination intermediates. Has a substrate preference for branched DNA structures with a 5-prime end at the branch nick with cleavage probably occurring approximately half a helical turn upstream of the free 5-prime end. Resolves the four-way Holliday junction (HJ) in which the two recombining DNAs are covalently-linked junctions in crossover formation during meiotic recombination, however, its ability to cut intact HJs was found to be very limited in comparison with other structures, suggesting that a HJ precursor (such as a nicked HJ) might be its preferred DNA substrate. In mitotic cells, the activity of MUS81-MMS4 is low during S-phase, but phosphorylation of the MMS4 leads to complex activation at the onset of mitosis by the collaborative actions of two cell cycle kinases: CDC28 (P00546) and CDC5 (P32562). Appears to be a complex of three heterodimers with a molecular weight = 500 kDa. - - - - - - psi-mi:"MI:0469"(IntAct) P38257(3)|Q04149(3) +CPX-1671 Prefoldin co-chaperone complex GIMC complex|Genes involved in microtubule biogenesis complex|Gim complex|GimC|PFD1:PFD2:PFD3:PFD4:PFD5:PFD6 559292 P40005(1)|P46988(1)|P48363(1)|P52553(1)|P53900(1)|Q04493(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-2342430 GO:0015631(tubulin binding)|GO:0016272(prefoldin complex)|GO:0006457(protein folding)|GO:0051082(unfolded protein binding) complex portal:CPX-1671(complex-primary) Hexameric molecular chaperone complex which interacts with nascent polypeptide chains, binds specifically to cytosolic chaperonin and transfers target proteins to it. Specifically promotes the formation of properly folded and functional alpha- and gamma-tubulin - Heterohexamer - - - - - psi-mi:"MI:0469"(IntAct) P40005(1)|P46988(1)|P48363(1)|P52553(1)|P53900(1)|Q04493(1) +CPX-1672 alpha-1,6-mannosyltransferase complex, M-Pol I variant M-Pol I complex|Mannan polymerase I|Mannosyltransferase Complex M-Pol I 559292 P23642(1)|P39107(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-2625310 GO:0000009(alpha-1,6-mannosyltransferase activity)|GO:0000136(alpha-1,6-mannosyltransferase complex)|GO:0097502(mannosylation)|GO:0000032(cell wall mannoprotein biosynthetic process) complex portal:CPX-1672(complex-primary)|pubmed:24026536(see-also) Role in the initiation and extension of an alpha -1,6-linked polymannose backbone as a first step in mannan synthesis, a branched polymer attached to the glycans of many of the proteins destined for the cell wall. - - - - - - - psi-mi:"MI:0469"(IntAct) P23642(1)|P39107(1) +CPX-1673 Replication fork protection complex FPC complex|TOF1-CSM3 complex 559292 P53840(0)|Q04659(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-1378348 GO:0048478(replication fork protection)|GO:0031298(replication fork protection complex)|GO:0006281(DNA repair)|GO:0043596(nuclear replication fork)|GO:0005634(nucleus) complex portal:CPX-1673(complex-primary)|pubmed:16418273(see-also) Required for chromosome segregation during meiosis and DNA damage repair. Acts at the intra-S-phase checkpoint pathway to stabilize stalled replication forks by maintaining the replisome at the arrested sites. Coordinates leading and lagging strand synthesis and moves with the replication fork. Stabilizes replication forks in a configuration that is recognized by replication checkpoint sensors and protects stalled replication forks against the fork-releasing activity of RRM3 helicase. - - - - - - - psi-mi:"MI:0469"(IntAct) P53840(0)|Q04659(0) +CPX-1674 MON1-CCZ1 complex Ccz1-Mon1 complex 559292 P38273(0)|P53129(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-1200786 GO:0035658(Mon1-Ccz1 complex)|GO:0032511(late endosome to vacuole transport via multivesicular body sorting pathway)|GO:0048278(vesicle docking)|GO:0097352(autophagosome maturation) complex portal:CPX-1674(complex-primary) Critical role in maintaining proper vacuole morphology in vacuole delivery pathways by regulating fusion of vesicles with the vacuole at the tethering/docking stage. Regulates the SNARE complex during the coordinated priming and docking stages of fusion. May play a role in early-to-late endosome conversion. - - - - - - - psi-mi:"MI:0469"(IntAct) P38273(0)|P53129(0) +CPX-1675 Septin complex - 559292 P25342(2)|P32457(2)|P32458(2)|P32468(2)|Q07657(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-2431364 GO:0031105(septin complex)|GO:0005525(GTP binding)|GO:0005200(structural constituent of cytoskeleton)|GO:0005619(ascospore wall)|GO:0000144(cellular bud neck septin ring)|GO:0032186(cellular bud neck septin ring organization) complex portal:CPX-1675(complex-primary)|pubmed:29979831(see-also) A heterooligomeric complex, formed from GTP-binding proteins, that polymerizes end-to-end into filaments at the bud neck. Play a role in cytokinesis, assembling early in the cell cycle as a patch at the incipient bud site and forming a ring approximate 15 minutes before bud emergence, which transforms into an hour-glass shaped collar of cortical filaments that spans both sides of the mother-bud neck. This collar persists until just before cytokinesis, when it splits into two rings that occupy opposite sides of the neck. The septins at the bud neck serve as a structural scaffold that recruits different components involved in diverse processes at specific stages during the cell cycle. Septins are also involved in cell morphogenesis, bud site selection, chitin deposition, cell cycle regulation, cell compartmentalization and spore wall formation. Septin protofilaments are composed of septin heterooctamers, with the core subunits CDC12-CDC3-CDC10-CDC10-CDC3-CDC12 with twof differential terminal subunitsCDC11 or SHS1, giving rise to two distinct septin heterooligomers. Octamers capped with CDC11polymerize end-to-end to form linear filaments that are often pairedwhilst the octamers capped with SHS1 appear to polymerize end-to-end into single filaments and/or laterally associate with each other into curved bundles or ring. - - - - - - psi-mi:"MI:0469"(IntAct) P25342(2)|P32457(2)|P32458(2)|P32468(2)|Q07657(0) +CPX-1676 ATG1 kinase complex Atg1-Atg13 complex 559292 P53104(2)|Q06410(2)|Q06628(2)|Q12092(2)|Q12421(2) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:1990316(ATG1/ULK1 kinase complex)|GO:0006468(protein phosphorylation)|GO:0005524(ATP binding)|GO:0042594(response to starvation)|GO:0000045(autophagosome assembly) pubmed:26753620(see-also)|complex portal:CPX-1676(complex-primary)|intenz:2.7.11.1(identity)|pubmed:25948417(see-also)|pubmed:20056399(see-also) Central regulator of autophagy initiation. Essential for recruitment of Atg proteins to the pre-autophagosomal structure, the putative site for autophagosome formation, under starvation condition, resulting in the sequestration of cytoplasmic proteins and organelles for bulk degradation. ATG13 is required for autophosphorylation of ATG1 at Thr-226 and its dimerization. A short alpha-helix of Atg13 binds to the hydrophobic groove formed between the first and the third alpha-helices of Atg1, whilst another longer alpha-helix of Atg13 binds to the hydrophobic groove formed between the second and the third alpha-helices of Atg1. Heterodecamer - - - - - psi-mi:"MI:0469"(IntAct) P53104(2)|Q06410(2)|Q06628(2)|Q12092(2)|Q12421(2) +CPX-1677 Phosphatidylinositol 3-kinase complex II VPS34 PI3-kinase complex II|Vps34 Ptdins 3-kinase complex II|Vps34 PtdIns 3 kinase complex II|BECN1:VPS15:VPS34:VPS38 559292 P22219(1)|P22543(1)|Q02948(1)|Q05919(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-820545 GO:0016303(1-phosphatidylinositol-3-kinase activity)|GO:0046854(phosphatidylinositol phosphorylation)|GO:0004674(protein serine/threonine kinase activity)|GO:0005524(ATP binding)|GO:0045324(late endosome to vacuole transport)|GO:0000139(Golgi membrane)|GO:0010008(endosome membrane)|GO:0034272(phosphatidylinositol 3-kinase complex, class III, type II) complex portal:CPX-1677(complex-primary)|wwpdb:5DFZ(identity)|wwpdb:5KC2(subset)|emdb:EMD-8235(subset)|intenz:2.7.11.1(identity)|intenz:2.7.1.137(identity)|pubmed:18533003(see-also) Catalyzes phosphorylation of phosphatidyl inositol, one of the major phospholipids in the cell, specifically at the d-3 position of the inositol ring, to generate PtdIns(3)P. Directs the synthesis of a specific endosomal pool of PtdIns3P, which is required for recruitment/activation of the retromer complex, thereby ensuring efficient endosome-to-Golgi retrograde transport. Y-shaped organization with two long arms and a short hook-like base. The VPS15 and VPS34 subunits intertwine in one arm so that the VPS15 kinase domain interacts with the lipid-binding region of the VPS34 kinase domain in an antiparallel fashion. The serine/threonine kinase VPS15 could influence VPS34 by stabilizing the enzyme, inhibiting basal activity by restricting the activation loop, and also contributing to membrane recruitment. The other arm of the complex consists of a parallel VPS30/VPS38 heterodimer. VPS30 and VPS38 interact along their entire lengths, forming an elongated structure that fits like a bracket around the VPS15/VPS34 heterodimer, along which VPS38 and, to a lesser extent, VPS30 make multiple contacts with VPS15/VPS34. Heterotetramer - - - - - psi-mi:"MI:0469"(IntAct) P22219(1)|P22543(1)|Q02948(1)|Q05919(1) +CPX-1678 TRAMP complex variant 4-1 Trf4/5–Air1/2–Mtr4 polyadenylation complex|TRAMP complex|TRF4 complex|TRAMP4 complex 559292 P40507(0)|P40985(0)|P47047(0)|P53632(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-2209909 GO:0031499(TRAMP complex)|GO:0003723(RNA binding)|GO:0000292(RNA fragment catabolic process)|GO:0034062(5'-3' RNA polymerase activity) complex portal:CPX-1678(complex-primary)|intenz:2.3.2.26(identity)|intenz:3.6.4.13(identity)|pubmed:32561742(see-also)|intenz:2.7.7.19(identity)|pubmed:18657638(see-also)|rhea:RHEA:11332(identity)|rhea:RHEA:13065(identity)|pubmed:25175027(see-also) Recognises and bind to splicing-defective pre-mRNAs and spliced-out introns leading to their rapid degradation by the nuclear exosome (CPX-599). Adds a short oligo(A) tail to the RNA which is assumed to make it a better substrate for 3'-end degradation. There is evidence that the various TRAMP complexes (CPX-1678, CPX-1679, CPX-1680) exhibit some substrate specificity. MTR4 contains a distinctive arch domain (IPR025696) consisting of a beta-barrel stalk inserted into a DExH core. The arch domain is specifically bound by ribosomal biogenesis factors carrying an arch-interacting motif (AIM), enabling direct MTR4 recruitment to pre-ribosomal RNAs. When bound to the exosome, MTR4 is positioned at the entrance to the central lumen enabling RNAs to pass through its helicase domain directly into the exosome. - - - - - - psi-mi:"MI:0469"(IntAct) P40507(0)|P40985(0)|P47047(0)|P53632(0) +CPX-1679 TRAMP complex variant 4-2 Trf4/5–Air1/2–Mtr4 polyadenylation complex|TRAMP complex|TRF4 complex 559292 P40985(0)|P47047(0)|P53632(0)|Q12476(0) ECO:0005546(biological system reconstruction evidence based on paralogy evidence used in manual assertion) - GO:0034062(5'-3' RNA polymerase activity)|GO:0003723(RNA binding)|GO:0031499(TRAMP complex)|GO:0000292(RNA fragment catabolic process) wwpdb:4u4c(subset)|complex portal:CPX-1679(complex-primary)|rhea:RHEA:13065(identity)|pubmed:32561742(see-also)|pubmed:25175027(see-also)|wwpdb:3nyb(subset)|intenz:2.7.7.19(identity)|complex portal:CPX-1678(inferred-from)|pubmed:18657638(see-also)|intenz:2.3.2.26(identity)|intenz:3.6.4.13(identity)|rhea:RHEA:11332(identity) Recognises and bind to splicing-defective pre-mRNAs and spliced-out introns leading to their rapid degradation by the nuclear exosome (CPX-599). Adds a short oligo(A) tail to the RNA which is assumed to make it a better substrate for 3'-end degradation. There is evidence that the various TRAMP complexes (CPX-1678, CPX-1679, CPX-1680) exhibit some substrate specificity with TRAMP4-2 targetting RNAPII transcripts, particularly mRNA 5' ends, close to the transition start site and also the CUT, SUT, and XUT ncRNAs. - - - - - - - psi-mi:"MI:0469"(IntAct) P40985(0)|P47047(0)|P53632(0)|Q12476(0) +CPX-1680 TRAMP complex variant 5-1 TRF5 complex|TRAMP5 complex|Trf4/5–Air1/2–Mtr4 polyadenylation complex 559292 P40507(0)|P47047(0)|P48561(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-2206291 GO:0031499(TRAMP complex)|GO:0003723(RNA binding)|GO:0000292(RNA fragment catabolic process)|GO:0034062(5'-3' RNA polymerase activity) complex portal:CPX-1680(complex-primary)|rhea:RHEA:11332(identity)|pubmed:32561742(see-also)|pubmed:18657638(see-also)|intenz:2.7.7.19(identity) Recognises and bind to splicing-defective pre-mRNAs and spliced-out introns leading to their rapid degradation by the nuclear exosome (CPX-599). Adds a short oligo(A) tail to the RNA which is assumed to make it a better substrate for 3'-end degradation. There is evidence that the various TRAMP complexes (CPX-1678, CPX-1679, CPX-1680) exhibit some substrate specificity with TRAMP5-1 preferentially targeting the ITS1 spacer region of 35S pre-rRNA MTR4 contains a distinctive arch domain (IPR025696) consisting of a beta-barrel stalk inserted into a DExH core. The arch domain is specifically bound by ribosomal biogenesis factors carrying an arch-interacting motif (AIM), enabling direct MTR4 recruitment to pre-ribosomal RNAs. When bound to the exosome, MTR4 is positioned at the entrance to the central lumen enabling RNAs to pass through its helicase domain directly into the exosome. - - - - - - psi-mi:"MI:0469"(IntAct) P40507(0)|P47047(0)|P48561(0) +CPX-1681 Monopolin complex - 559292 P25651(0)|P29295(0)|P40065(0)|Q04087(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0033551(monopolin complex)|GO:0045132(meiotic chromosome segregation)|GO:0004674(protein serine/threonine kinase activity)|GO:0005524(ATP binding) complex portal:CPX-1681(complex-primary)|intenz:2.7.11.1(identity)|rhea:RHEA:17989(identity)|wwpdb:3n7n(subset)|pubmed:19308704(see-also) Essential for clamping microtubule binding sites, ensuring orientation of sister kinetochores to the same pole (monopolar kinetochore attachment) during meiosis I. - - - - - - - psi-mi:"MI:0469"(IntAct) P25651(0)|P29295(0)|P40065(0)|Q04087(0) +CPX-1682 Histone acetyltransferase B HAT-B 559292 P39984(0)|Q12341(0)|Q12373(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0016573(histone acetylation)|GO:0005634(nucleus)|GO:0006348(chromatin silencing at telomere)|GO:0000123(histone acetyltransferase complex)|GO:0004402(histone acetyltransferase activity) complex portal:CPX-1682(complex-primary)|intenz:2.3.1.48(identity) Acetylate Lys-12 and Lys-5 of non-chromatin-bound histone H4, an essential step in the regulation of chromatin activity and of telomeric silencing. - - - - - - - psi-mi:"MI:0469"(IntAct) P39984(0)|Q12341(0)|Q12373(0) +CPX-1683 DBF2-MOB1 kinase complex DBF2-MOB1 559292 P22204(1)|P40484(1) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0004674(protein serine/threonine kinase activity)|GO:0006468(protein phosphorylation)|GO:0034973(Sid2-Mob1 complex)|GO:0032465(regulation of cytokinesis)|GO:0010458(exit from mitosis) complex portal:CPX-1683(complex-primary)|rhea:RHEA:17989(identity)|wwpdb:5ncn(identity)|pubmed:22573892(see-also)|pubmed:9528782(see-also)|intenz:2.7.11.1(identity)|rhea:RHEA:46608(identity) Role in exit from mitosis during the cell cycle. Once activated, translocates to the nucleus where it phosphorylates an unknown protein to dislodge CDC14 (Q00684) from NET1 (P47035), resulting in diffusion of CDC14 throughout the nucleus. Phosphorylates CDC14 on several sites that flank the C-terminal nuclear localization signal (NLS) sequences, thereby inhibiting the NLS. Because of this, phosphorylated CDC14 molecules that escape to the cytoplasm cannot efficiently return to the nucleus and dephosphorylate substrates such as CDH1 (P53197) and SWI5 (P08153). Phosphorylates chitin synthase CHS2 (P14180) to regulate cytokinesis. - Heterodimer - - - - - psi-mi:"MI:0469"(IntAct) P22204(1)|P40484(1) +CPX-1684 CBK1-MOB2 kinase complex CBK1-MOB2 559292 P43563(0)|P53894(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-16157345 GO:0030295(protein kinase activator activity)|GO:0006468(protein phosphorylation)|GO:0000920(septum digestion after cytokinesis)|GO:0007163(establishment or maintenance of cell polarity)|GO:0005524(ATP binding)|GO:1902554(serine/threonine protein kinase complex)|GO:0005934(cellular bud tip)|GO:0005935(cellular bud neck)|GO:0005634(nucleus) complex portal:CPX-1684(complex-primary)|rhea:RHEA:17989(identity)|wwpdb:4LQQ(identity)|wwpdb:4LQP(identity)|wwpdb:4LQS(identity)|pubmed:25966461(see-also)|intenz:2.7.11.1(identity)|rhea:RHEA:46608(identity) Required for the final event of cell division, destruction of an extracellular septum that forms between mother and daughter cells during cytokinesis. Plays a role in the RAM pathway which regulates the ACE2 (P21192) transcription factor, which turns on expression of septum-destroying hydrolases and plays a role in the polarized morphogenesis of bud site selection, bud development, and cell separation. The complex is ctivated by the hippo-like kinase KIC1 (P38692). MOB2 binding creates a novel binding pocket that participates in the formation of the active state of NDR/LATS kinases after they are phosphorylated by MST/hippo kinases. - - - - - - psi-mi:"MI:0469"(IntAct) P43563(0)|P53894(0) +CPX-1685 BUR1-BUR2 kinase complex BUR1-BUR2|BUR kinase complex|BUR1/BUR2 559292 P23293(0)|Q05949(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-970113 GO:0006351(transcription, DNA-templated)|GO:0000307(cyclin-dependent protein kinase holoenzyme complex)|GO:0004693(cyclin-dependent protein serine/threonine kinase activity)|GO:0006468(protein phosphorylation)|GO:0008353(RNA polymerase II CTD heptapeptide repeat kinase activity)|GO:0005524(ATP binding) complex portal:CPX-1685(complex-primary)|rhea:RHEA:17989(identity)|rhea:RHEA:46608(identity)|rhea:RHEA:10216(identity)|pubmed:10982824(see-also)|intenz:2.7.11.22(identity)|intenz:2.7.11.23(identity) Implicated in transcription elongation. Phosphorylates the UBC2/RAD6 ubiquitin-conjugating enzyme (E2), leading to monoubiquitination of histone H2B, the localization of the PAF1 complex (CPX-1726) to chromatin, and the silencing of telomeric-associated genes. Also required for histone H3 Lys-4 trimethylation. Recruited to the C-terminal repeat domain of the largest subunit of RNA Pol II, RPB1 (P04050), phosphorylated on Ser-5 to augment Ser-2 phosphorylation by the carboxy-terminal domain protein kinase complex (CPX-1710) early in the transcription cycle. - - - - - - - psi-mi:"MI:0469"(IntAct) P23293(0)|Q05949(0) +CPX-1686 TREX-2 transcription-export complex THSC complex|Transcription export complex 2|Three prime repair exonuclease 2 559292 P06704(0)|P46674(0)|Q08231(0)|Q6WNK7(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-1370592 GO:0070390(transcription export complex 2)|GO:0045944(positive regulation of transcription from RNA polymerase II promoter)|GO:0006406(mRNA export from nucleus) wwpdb:3fwc(subset)|complex portal:CPX-1686(complex-primary)|wwpdb:3T5V(subset)|wwpdb:3FWB(subset) Couples SAGA-dependent gene expression and transcription elongation to mRNA export at the inner side of the nuclear pore complex (NPC). The TREX-2 complex is tethered to the inner side of the NPC via the nucleoporins NUP1 and NUP60 and facilitates the repositioning and association of actively transcribing genes with nuclear pores (gene gating). Provides a feedback mechanism for the control of transcription and the preservation of genetic integrity of transcribed DNA regions. SAC3 forms a long, gently undulating α helix around which one CDC31 and two SUS1 chains are wrapped. SUS1 has an articulated helical hairpin fold that facilitates its wrapping around SAC3. - - - - - - psi-mi:"MI:0469"(IntAct) P06704(0)|P46674(0)|Q08231(0)|Q6WNK7(0) +CPX-1687 Thp1-Sac3 complex SAC3-THP1 complex 559292 P46674(0)|Q08231(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-1370691 GO:0045944(positive regulation of transcription from RNA polymerase II promoter)|GO:0006406(mRNA export from nucleus)|GO:0043021(ribonucleoprotein complex binding) complex portal:CPX-1687(complex-primary) Functions in transcription-coupled mRNA export from the nucleus to the cytoplasm. Dock export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket), by association with components of the nuclear mRNA export machinery (MEX67-MTR2 and SUB2) in the nucleoplasm and the nucleoporin NUP1 at the nuclear basket. - - - - - - - psi-mi:"MI:0469"(IntAct) P46674(0)|Q08231(0) +CPX-1688 PHO80-PHO85 kinase complex PHO80-PHO85 complex 559292 P17157(1)|P20052(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-2346404 GO:0000307(cyclin-dependent protein kinase holoenzyme complex)|GO:0004693(cyclin-dependent protein serine/threonine kinase activity)|GO:0006468(protein phosphorylation)|GO:0043433(negative regulation of DNA-binding transcription factor activity)|GO:0045936(negative regulation of phosphate metabolic process) complex portal:CPX-1688(complex-primary)|rhea:RHEA:17989(identity)|rhea:RHEA:46608(identity)|wwpdb:2PK9(identity)|wwpdb:2PMI(identity)|pubmed:18042456(see-also)|intenz:2.7.11.22(identity) Cyclin-dependent protein kinase that negatively regulates the phosphate starvation response by controlling both the localization and activity of the transcription factor PHO4 (P07270). PHO4, in turn, activates transcription of phosphate acquisition genes. - Heterodimer - - - - - psi-mi:"MI:0469"(IntAct) P17157(1)|P20052(1) +CPX-1689 PCL6-PHO85 kinase complex - 559292 P17157(1)|P40038(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-1150924 GO:0005979(regulation of glycogen biosynthetic process)|GO:0000307(cyclin-dependent protein kinase holoenzyme complex)|GO:0004693(cyclin-dependent protein serine/threonine kinase activity) complex portal:CPX-1689(complex-primary)|rhea:RHEA:17989(identity)|rhea:RHEA:46608(identity)|intenz:2.7.11.22(identity) Cyclin-dependent protein kinase which phosphorylates and inactivates GLC8 (P41818), which then modulates GLC7 type-1 protein phosphatase (P38229), thus controlling glycogen phosphorylase and glycogen synthase activities in response to nutrient availability. - Heterodimer - - - - - psi-mi:"MI:0469"(IntAct) P17157(1)|P40038(1) +CPX-1690 PCL7-PHO85 kinase complex - 559292 P17157(1)|P40186(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-1150936 GO:0005979(regulation of glycogen biosynthetic process)|GO:0000307(cyclin-dependent protein kinase holoenzyme complex)|GO:0004693(cyclin-dependent protein serine/threonine kinase activity) complex portal:CPX-1690(complex-primary)|intenz:2.7.11.22(identity)|rhea:RHEA:46608(identity)|rhea:RHEA:17989(identity) Cyclin-dependent protein kinase that phosphorylates and inactivates GLC8 (P41818), which then modulates GLC7 type-1 protein phosphatases (P38229), thus controlling glycogen phosphorylase and glycogen synthase activities in response to nutrient availability. - Heterodimer - - - - - psi-mi:"MI:0469"(IntAct) P17157(1)|P40186(1) +CPX-1691 PCL8-PHO85 kinase complex - 559292 P17157(1)|Q08966(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-1150943 GO:0004693(cyclin-dependent protein serine/threonine kinase activity)|GO:0000307(cyclin-dependent protein kinase holoenzyme complex)|GO:0005979(regulation of glycogen biosynthetic process) complex portal:CPX-1691(complex-primary)|rhea:RHEA:46608(identity)|rhea:RHEA:17989(identity)|intenz:2.7.11.22(identity) Cyclin-dependent protein kinase that phosphorylates and inactivates GSY2 (P27472), a regulatory enzyme in glycogen synthesis, thus controlling glycogen synthase activities in response to nutrient availability. - Heterodimer - - - - - psi-mi:"MI:0469"(IntAct) P17157(1)|Q08966(1) +CPX-1692 PCL10-PHO85 kinase complex - 559292 P17157(1)|P53124(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-1150948 GO:0004693(cyclin-dependent protein serine/threonine kinase activity)|GO:0005979(regulation of glycogen biosynthetic process)|GO:0000307(cyclin-dependent protein kinase holoenzyme complex) complex portal:CPX-1692(complex-primary)|rhea:RHEA:17989(identity)|rhea:RHEA:46608(identity)|rhea:RHEA:46608(identity)|intenz:2.7.11.22(identity) Cyclin-dependent protein kinase that phosphorylates and inactivates GSY2 (P27472), a regulatory enzyme in glycogen synthesis, thus controlling glycogen synthase activities in response to nutrient availability. - Heterodimer - - - - - psi-mi:"MI:0469"(IntAct) P17157(1)|P53124(1) +CPX-1693 CLG1-PHO85 kinase complex - 559292 P17157(1)|P35190(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-1150911 GO:0004693(cyclin-dependent protein serine/threonine kinase activity)|GO:0000307(cyclin-dependent protein kinase holoenzyme complex)|GO:0051726(regulation of cell cycle)|GO:0016239(positive regulation of macroautophagy) complex portal:CPX-1693(complex-primary)|pubmed:28357278(see-also)|rhea:RHEA:17989(identity)|rhea:RHEA:46608(identity)|intenz:2.7.11.22(identity) Cyclin-dependent protein kinase with a role in cell integrity and polarized cell growth. Phosphorylates the chaperone protein SSA1 (P10591), a chaperone that is essential for protection of the cyclin CLN3 (P13365), essential for the control of the cell cycle at the G1/S (start) transition, from the degradation machinery. Acts to positively regulate autophagy through promoting the degradation of SIC1, a negative regulator of autophagy. - Heterodimer - - - - - psi-mi:"MI:0469"(IntAct) P17157(1)|P35190(1) +CPX-1694 PCL2-PHO85 kinase complex - 559292 P17157(1)|P25693(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-1150834 GO:0000307(cyclin-dependent protein kinase holoenzyme complex)|GO:0004693(cyclin-dependent protein serine/threonine kinase activity)|GO:0001676(long-chain fatty acid metabolic process)|GO:0044843(cell cycle G1/S phase transition)|GO:0051302(regulation of cell division)|GO:0005935(cellular bud neck)|GO:0030952(establishment or maintenance of cytoskeleton polarity) complex portal:CPX-1694(complex-primary)|rhea:RHEA:17989(identity)|rhea:RHEA:46608(identity)|intenz:2.7.11.22(identity) Cyclin-dependent protein kinase essential for the control of the cell cycle at the G1/S (start) transition. Phosphorylates RVS167 which functions in actin cytoskeleton regulation and is required for the formation of endocytic vesicles at the plasma membrane. Positively controls degradation of sphingoid long chain base kinase LCB4 (Q12246) by phosphorylation, which is required for its ubiquitination and degradation. LCB4 catalyses the formation of sphingoid long-chain base 1-phosphates which have roles in roles in heat stress resistance, diauxic shift, and Ca2+ mobilization. - Heterodimer - - - - - psi-mi:"MI:0469"(IntAct) P17157(1)|P25693(1) +CPX-1695 PCL1-PHO85 kinase complex Pho85/Pcl1 complex|Pcl1-Pho85 complex|Pcl1/Pho85 complex|Pho85-Pcl1 complex 559292 P17157(1)|P24867(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-1150974 GO:0000307(cyclin-dependent protein kinase holoenzyme complex)|GO:0004693(cyclin-dependent protein serine/threonine kinase activity)|GO:0001676(long-chain fatty acid metabolic process)|GO:0051302(regulation of cell division)|GO:0000082(G1/S transition of mitotic cell cycle)|GO:0005935(cellular bud neck) complex portal:CPX-1695(complex-primary)|rhea:RHEA:17989(identity)|rhea:RHEA:46608(identity)|intenz:2.7.11.22(identity) Cyclin-dependent protein kinase essential for the control of the cell cycle at the G1/S (start) transition. Positively controls degradation of sphingoid long chain base kinase LCB4 (Q12246) by phosphorylation, which is required for its ubiquitination and degradation. LCB4 catalyses the formation of sphingoid long-chain base 1-phosphates which have roles in roles in heat stress resistance, diauxic shift, and Ca2+ mobilization. Also involved in phosphorylation of the CDK inhibitor (CKI) SIC1 (P38634), which is required for its ubiquitination and degradation, releasing repression of B-type cyclins and promoting exit from mitosis. - Heterodimer - - - - - psi-mi:"MI:0469"(IntAct) P17157(1)|P24867(1) +CPX-1696 PCL5-PHO85 kinase complex Pho85/Pcl5 complex|Pcl5-Pho85 complex|Pcl5/Pho85 complex|Pho85-Pcl5 complex 559292 P17157(1)|P38794(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-1150974 GO:0000307(cyclin-dependent protein kinase holoenzyme complex)|GO:0004693(cyclin-dependent protein serine/threonine kinase activity)|GO:0043433(negative regulation of DNA-binding transcription factor activity) complex portal:CPX-1696(complex-primary)|rhea:RHEA:17989(identity)|rhea:RHEA:46608(identity)|intenz:2.7.11.22(identity) Cyclin-dependent protein kinase that positively controls degradation of transcription factor GCN4 (P03069) under favorable growth conditions. GCN4 is a master transcriptional regulator of amino acid and vitamin biosynthetic enzymes, whose expression is upregulated in response to amino acid starvation Phosphorylation of GCN4 is required for its degradation by the E3 ubiquitin ligase complex SCF-Cdc4 (CPX-3234). Amino acid starvation reduces PCL5-PHO85-associated GCN4 kinase activity and leads to stabilization of GCN4 - Heterodimer - - - - - psi-mi:"MI:0469"(IntAct) P17157(1)|P38794(1) +CPX-1697 PCL9-PHO85 kinase complex Pho85/Pcl9 complex|Pcl9-Pho85 complex|Pcl9/Pho85 complex|Pho85-Pcl9 complex 559292 P17157(1)|Q12477(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-1150974 GO:0000083(regulation of transcription involved in G1/S transition of mitotic cell cycle)|GO:0000307(cyclin-dependent protein kinas)|GO:0004693(cyclin-dependent protein kinas) complex portal:CPX-1697(complex-primary)|intenz:2.7.11.22(identity) Active in the M/G1 phase of the cell cycle. - Heterodimer - - - - - psi-mi:"MI:0469"(IntAct) P17157(1)|Q12477(1) +CPX-1698 EMP24 complex p24 complex|ERP1:ERP2:ERV24:TMEDA 559292 P32803(0)|P39704(0)|P54837(0)|Q05359(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-794066 GO:0006900(vesicle budding from membrane)|GO:0005798(Golgi-associated vesicle)|GO:0006888(ER to Golgi vesicle-mediated transport)|GO:0030176(integral component of endoplasmic reticulum membrane) complex portal:CPX-1698(complex-primary)|pubmed:11560939(see-also)|pubmed:19566487(see-also) Plays a role in selective transport processes at the ER-Golgi interface by tethering both COPI (CPX-1652) and COPII (CPX-2523) complexes via dilysine motives on EMP24 and ERV25. May initially recruit the deactivated form of ARF1 (P11076), facilitating the formation of a COPI priming complex and subsequently enabling efficient budding. In addition, the ability of p24 proteins to oligomerize and to present multiple coatomer-binding motifs may promote COPI budding by docking coatomer more firmly to the membrane. Required for the export of glycosylphosphatidylinositol-anchored proteins to the Golgi apparatus through interaction with the SEC23-LST1 COPII cargo recruitment complex (CPX-1341). - - - - - - - psi-mi:"MI:0469"(IntAct) P32803(0)|P39704(0)|P54837(0)|Q05359(0) +CPX-1699 CLN1-CDC28 kinase complex CDK1-CG11 complex 559292 P00546(0)|P20437(0)|P20486(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-392961 GO:0000307(cyclin-dependent protein kinase holoenzyme complex)|GO:1902806(regulation of cell cycle G1/S phase transition)|GO:0004693(cyclin-dependent protein serine/threonine kinase activity) complex portal:CPX-1699(complex-primary)|intenz:2.7.11.22(identity) Cyclin-dependent protein kinase complex required for the control of the cell cycle at the G1/S (start) transition, controlling the trigger of post-Start processes such as spindle pole body duplication, and the initiation of DNA replication. CSK1 is required for activity of CLN-CDC28 complexes. The protein may also play a role in complex stability and substrate recognition. CDKs have a two-lobed structure. The amino-terminal lobe contains beta-sheets, the carboxy-terminal lobe is rich in alpha-helices, and the active site is sandwiched in-between. In the cyclin-free, monomeric form the CDK catalytic cleft is closed by a region known as the T-loop, preventing enzymatic activity. Cyclin binding leads to a conformational change, enabling activation of catalytic activity. - - - - - - psi-mi:"MI:0469"(IntAct) P00546(0)|P20437(0)|P20486(0) +CPX-1700 CLN3-CDC28 kinase complex CDK1-CG13 complex 559292 P00546(0)|P13365(0)|P20486(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-392964 GO:1902806(regulation of cell cycle G1/S phase transition)|GO:0000307(cyclin-dependent protein kinase holoenzyme complex)|GO:0004693(cyclin-dependent protein serine/threonine kinase activity) complex portal:CPX-1700(complex-primary)|intenz:2.7.11.22(identity) Cyclin-dependent protein kinase complex required for the control of the cell cycle at the G1/S (start) transition, controlling the trigger of post-Start processes such as spindle pole body duplication, and the initiation of DNA replication. CSK1 is required for activity of CLN-CDC28 complexes. The protein may also play a role in complex stability and substrate recognition. CDKs have a two-lobed structure. The amino-terminal lobe contains beta-sheets, the carboxy-terminal lobe is rich in alpha-helices, and the active site is sandwiched in-between. In the cyclin-free, monomeric form the CDK catalytic cleft is closed by a region known as the T-loop, preventing enzymatic activity. Cyclin binding leads to a conformational change, enabling activation of catalytic activity. - - - - - - psi-mi:"MI:0469"(IntAct) P00546(0)|P13365(0)|P20486(0) +CPX-1701 CLB2-CDC28 kinase complex CDK1-CG22 complex 559292 P00546(0)|P24869(0) ECO:0005546(biological system reconstruction evidence based on paralogy evidence used in manual assertion) - GO:0000086(G2/M transition of mitotic cell cycle)|GO:0004693(cyclin-dependent protein serine/threonine kinase activity)|GO:0000307(cyclin-dependent protein kinase holoenzyme complex)|GO:0006974(cellular response to DNA damage stimulus) complex portal:CPX-1702(inferred-from)|complex portal:CPX-1701(complex-primary)|intenz:2.7.11.22(identity) Cyclin-dependent protein kinase complex required for the control of the cell cycle at the G2/M (mitosis) transition. Mitotic cyclin-CDKs (M-CDKs) regulate accurate chromosome segregation through mitosis. Also plays a role in enhancing double-stranded DNA damage response and repair by targeting the chromatin remodeling factor Fun30. CDKs have a two-lobed structure. The amino-terminal lobe contains beta-sheets, the carboxy-terminal lobe is rich in alpha-helices, and the active site is sandwiched in-between. In the cyclin-free, monomeric form the CDK catalytic cleft is closed by a region known as the T-loop, preventing enzymatic activity. Cyclin binding leads to a conformational change, enabling activation of catalytic activity. - - - - - - psi-mi:"MI:0469"(IntAct) P00546(0)|P24869(0) +CPX-1702 CLB5-CDC28 kinase complex CDK1-CGS5 complex|CDK-S complex 559292 P00546(0)|P30283(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-11565889 GO:0004693(cyclin-dependent protein serine/threonine kinase activity)|GO:0006974(cellular response to DNA damage stimulus)|GO:0000307(cyclin-dependent protein kinase holoenzyme complex)|GO:0000083(regulation of transcription involved in G1/S transition of mitotic cell cycle) complex portal:CPX-1702(complex-primary)|intenz:2.7.11.22(identity) Cyclin-dependent protein kinase complex required for the control of the cell cycle during S-phase where it is required to activate DNA replication. Essential for initiation of meiotic recombination because it phosphorylates Ser-30 of MER2, a meiosis-specific double-strand break (DSB) protein, which primes Mer2 for subsequent phosphorylation by DDK on Ser29, creating a negatively charged patch necessary for DSB formation. Also plays a role in enhancing DNA damage response and repair by targeting the chromatin remodeling factor Fun30. CDKs have a two-lobed structure. The amino-terminal lobe contains beta-sheets, the carboxy-terminal lobe is rich in alpha-helices, and the active site is sandwiched in-between. In the cyclin-free, monomeric form the CDK catalytic cleft is closed by a region known as the T-loop, preventing enzymatic activity. Cyclin binding leads to a conformational change, enabling activation of catalytic activity. - - - - - - psi-mi:"MI:0469"(IntAct) P00546(0)|P30283(0) +CPX-1703 Prohibitin complex PHB1-PHB2 559292 P40961(0)|P50085(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-1253815 GO:0035632(mitochondrial prohibitin complex)|GO:0050821(protein stabilization)|GO:0007005(mitochondrion organization) complex portal:CPX-1703(complex-primary)|pubmed:12237468(see-also)|pubmed:15489194(see-also) Chaperone which functions to protect the cell from imbalances in the production of mitochondrial proteins by stabilizing newly synthesised mitochondrial-encoded proteins. Prohibitin-deficient cells have a reduced replicative lifespan, associated with mitochondrial decline and display morphological changes of aging. Assembles into a membrane-associated ring-shaped supercomplex of approximately 1 mDa. - - - - - - psi-mi:"MI:0469"(IntAct) P40961(0)|P50085(0) +CPX-1704 MSH4-MSH5 complex - 559292 P40965(1)|Q12175(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-1373447 GO:0007131(reciprocal meiotic recombination) complex portal:CPX-1704(complex-primary)|pubmed:26686657(see-also)|pubmed:17674148(see-also) Directly promotes steps in crossover-forming homologous recombination in DNA by stabilizing crossover-destined recombination intermediates. - - - - - - - psi-mi:"MI:0469"(IntAct) P40965(1)|Q12175(1) +CPX-1705 BUD14-GLC7 phosphatase complex Bud14p-Glc7p complex 559292 CHEBI:29035(2)|P27637(0)|P32598(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-1369026 GO:0000164(protein phosphatase type 1 complex)|GO:0000282(cellular bud site selection)|GO:0004722(protein serine/threonine phosphatase activity)|GO:0030837(negative regulation of actin filament polymerization)|GO:0000131(incipient cellular bud site)|GO:0045944(positive regulation of transcription from RNA polymerase II promoter) pubmed:16107882(see-also)|complex portal:CPX-1705(complex-primary)|intenz:3.1.3.16(identity) Protein phosphatase complex which is important for bud site selection. Regulates microtubule dynamics at the cortex by acting as a specific activator of the dynein complex at the bud cortex. May also play a role in the regulation of transcription by the CCR4-NOT complex (CPX-1800) by phosphorylating and modifying the activity of the MSN2 transcription factor (P33748). - - - - - - - psi-mi:"MI:0469"(IntAct) P27637(0)|P32598(1) +CPX-1706 acyl-CoA ceramide synthase complex Acyl-coA-dependent ceramide synthase 559292 P28496(1)|P38703(1)|Q03579(2) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-2355147 GO:0061576(acyl-CoA ceramide synthase complex)|GO:0050291(sphingosine N-acyltransferase activity)|GO:0046513(ceramide biosynthetic process) complex portal:CPX-1706(complex-primary)|pubmed:15692566(see-also)|intenz:2.3.1.24(identity)|rhea:RHEA:23768(identity)|rhea:RHEA:33351(identity)|rhea:RHEA:36555(identity)|rhea:RHEA:34735(identity)|rhea:RHEA:35651(identity) Synthesizes ceramide from the reaction of a C26 fatty acyl-CoA with a sphingoid base, thus controlling cell growth, and mediating different cellular events, such as apoptosis, growth arrest, endocytosis and stress response. Molecular weight = approximately 250-260 kDa. Heterotetramer - - - - - psi-mi:"MI:0469"(IntAct) P28496(1)|P38703(1)|Q03579(2) +CPX-1707 Ornithine carbamoyltransferase arginase complex OTC-ARGI complex|Ornithine carbamoyltransferase inhibitor complex 559292 CHEBI:29035(6)|P00812(3)|P05150(3) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-2355816 GO:0004053(arginase activity)|GO:1903269(ornithine carbamoyltransferase inhibitor complex) complex portal:CPX-1707(complex-primary)|rhea:RHEA:20569(identity)|pubmed:12679340(see-also)|intenz:3.5.3.1(identity) Complex in which the activity of ornithine carbamoyltransferase (OTCase) is inhibited whereas arginase remains catalytically active thus preventing the recycling of ornithine produced by arginase by OTCase - an example of epiarginase control. Complex forms in the presence of ornithine and arginine. - Heterohexamer - - - - - psi-mi:"MI:0469"(IntAct) P00812(3)|P05150(3) +CPX-1708 Nucleotide-excision repair factor 1 complex NEF1 559292 P06777(0)|P06838(0)|P28519(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-2410704 GO:0000110(nucleotide-excision repair factor 1 complex)|GO:0003684(damaged DNA binding)|GO:0000715(nucleotide-excision repair, DNA damage recognition)|GO:0004519(endonuclease activity) complex portal:CPX-1708(complex-primary) Role in nucleotide-excision repair; possesses DNA damage recognition and endodeoxynuclease activities. - - - - - - - psi-mi:"MI:0469"(IntAct) P06777(0)|P06838(0)|P28519(0) +CPX-1709 Nucleotide excision repair factor 4 complex NEF4 complex|GG-NER|Global genome nucleotide excision repair complex 559292 P06779(0)|P14164(0)|P31244(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0070911(global genome nucleotide-excision repair)|GO:0003690(double-stranded DNA binding)|GO:0016818(hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides)|GO:0000113(nucleotide-excision repair factor 4 complex) pubmed:10601031(see-also)|complex portal:CPX-1709(complex-primary)|pubmed:10915862(see-also) An ATP-dependent damage recognition factor required for repair of damaged, nontranscribed DNA, in a process whereby DNA is incised on both sides of the lesion, resulting in the removal of a fragment approximately 25-30 nucleotides long. Locates damage on the non-transcribed strand and in transcriptionally inactive regions of the genome, with ABF1 binding to specific sites increasing the efficiency of the repair process. RAD16 appears to generate superhelical torsion in the DNA in one direction originating from the ABF1-binding site and may remodel chromatin to generate the space for DNA repair synthesis. Subsequent to binding the DNA lesion, the NEF4 complex may serve as a nucleation site for the assembly of the other repair components for dual incision to occur. - - - - - - - psi-mi:"MI:0469"(IntAct) P06779(0)|P14164(0)|P31244(0) +CPX-1710 Carboxy-terminal domain protein kinase complex C-terminal domain kinase I complex|CTD kinase|CTDK-I|Ctk1p complex|Ctk complex|CTDK complex|Trimeric positive transcription elongation factor complex b 559292 P46962(0)|P46963(0)|Q03957(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-2429681 GO:0031124(mRNA 3'-end processing)|GO:0070816(phosphorylation of RNA polymerase II C-terminal domain)|GO:0045943(positive regulation of transcription by RNA polymerase I)|GO:0045944(positive regulation of transcription by RNA polymerase II)|GO:0004693(cyclin-dependent protein serine/threonine kinase activity)|GO:0008353(RNA polymerase II CTD heptapeptide repeat kinase activity)|GO:0032806(carboxy-terminal domain protein kinase complex) complex portal:CPX-1710(complex-primary)|rhea:RHEA:10216(identity)|intenz:2.7.11.23(identity)|pubmed:16721054(see-also) Cyclin-dependent protein that phosphorylates RNA polymerase II (RNAPII, CPX-2662) on the carboxyl-terminal repeat domain (CTD) of its largest subunit RPB1 (P04050), which is important for efficient transcription elongation, mRNA 3′-end processing, and transcription termination of small noncoding RNAs. Also plays a role in RNA polymerase I (RNAPI, CPX-1664) transcription. Increases the correct decoding of mRNA during translation elongation by phosphorylating residue Ser-238 of RPS2 (P25443), a protein of the small ribosomal subunit (CPX-1599). Directs the association of SET2 (P46995) to RNAP II, which results in the establishment of H3K36 methylation and deacetylated chromatin in the bodies of genes. Also regulates SET1-mediated H3K4 methylation which marks the 5′ end of transcribed genes, promoting association of chromatin-remodeling and histone-modifying enzymes. Both the CTK2 cyclin and CTK3 are required for CTK1 kinase activation. CTK2 and CTK3 physical interaction is required to protect both subunits from degradation, and both interact independently with CTK1. - - - - - - psi-mi:"MI:0469"(IntAct) P46962(0)|P46963(0)|Q03957(0) +CPX-1711 RIX1 complex - 559292 P38803(0)|P38883(0)|P53877(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-2430137 GO:0031125(rRNA 3'-end processing)|GO:0000027(ribosomal large subunit assembly)|GO:0000054(ribosomal subunit export from nucleus)|GO:0097344(Rix1 complex) complex portal:CPX-1711(complex-primary) Required for 3-prime maturation of the 5.8 S rRNA, a late pre-rRNA processing step. May also play an essential role in ATP-dependent maturation and nuclear export of nascent 60S subunits from the nucleoplasm to the cytoplasm. - - - - - - - psi-mi:"MI:0469"(IntAct) P38803(0)|P38883(0)|P53877(0) +CPX-1712 Gin4 serine/threonine kinase complex Gin4-septin complex 559292 P25293(0)|P25342(0)|P32457(0)|P32458(0)|P32468(0)|P53890(0)|Q07657(0)|Q12263(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-2431293 GO:0071902(positive regulation of protein serine/threonine kinase activity)|GO:0004674(protein serine/threonine kinase activity)|GO:0000921(septin ring assembly)|GO:0000920(septum digestion after cytokinesis)|GO:1990317(Gin4 complex) complex portal:CPX-1712(complex-primary)|intenz:2.7.11.1(identity)|rhea:RHEA:17989(identity)|rhea:RHEA:46608(identity) Serine/threonine kinase complex that assembles when cells enter mitosis. The associated GIN4 molecules present in this complex phosphorylate each other, leading to GIN4 hyperphosphorylation and activation. This mechanism appears to ensure GIN4 is only activated during mitosis. GIN4 is involved in septin ring formation during mitosis. Contains at least 2 copies of GIN4. - - - - - - psi-mi:"MI:0469"(IntAct) P25293(0)|P25342(0)|P32457(0)|P32458(0)|P32468(0)|P53890(0)|Q07657(0)|Q12263(0) +CPX-1715 TORC1 serine/threonine-protein kinase complex, TOR1 variant TORC1|Target of rapamycin complex 1|TOR complex 1|TORC1 complex|Nutrient sensitive complex 559292 P35169(0)|P38873(0)|P41318(0)|Q08921(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-2435003 GO:0031931(TORC1 complex)|GO:0001558(regulation of cell growth)|GO:0051726(regulation of cell cycle)|GO:0031929(TOR signaling)|GO:0007584(response to nutrient)|GO:0004674(protein serine/threonine kinase activity)|GO:0005524(ATP binding) complex portal:CPX-1715(complex-primary)|pubmed:28638821(see-also)|intenz:2.7.11.1(identity)|rhea:RHEA:17989(identity)|rhea:RHEA:46608(identity)|pubmed:18215152(see-also) Serine/threonine-protein kinase signalling complex which senses diverse inputs, such as nitrogen- and carbon-containing nutrients, hormonal stimulation, various stresses, availability of energy within the cell and oxygen and mediates temporal control of cell growth via regulation of translation, transcription, ribosome biogenesis, nutrient transport, and autophagy. Coordinates cell size by regulating timing of G1-S cell cycle progression by mediating G1 cyclin/CDK activation as well as through destabilization of the SIC1 (P38634) CDK inhibitor. Inhibited by FKBP-rapamycin. - - - - - - psi-mi:"MI:0469"(IntAct) P35169(0)|P38873(0)|P41318(0)|Q08921(0) +CPX-1716 TORC1 serine/threonine-protein kinase complex, TOR2 variant TORC1|Target of rapamycin complex 1|TOR complex 1|TORC1 complex|Nutrient sensitive complex 559292 P32600(0)|P38873(0)|P41318(0)|Q08921(0) ECO:0005546(biological system reconstruction evidence based on paralogy evidence used in manual assertion) - GO:0001558(regulation of cell growth)|GO:0031931(TORC1 complex)|GO:0007584(response to nutrient)|GO:0031929(TOR signaling)|GO:0051726(regulation of cell cycle)|GO:0005524(ATP binding)|GO:0004674(protein serine/threonine kinase activity) complex portal:CPX-1716(complex-primary)|complex portal:CPX-1715(inferred-from)|pubmed:28638821(see-also)|intenz:2.7.11.1(identity)|rhea:RHEA:17989(identity)|rhea:RHEA:46608(identity)|pubmed:18215152(see-also) Serine/threonine-protein kinase signalling complex which senses diverse inputs, such as nitrogen- and carbon-containing nutrients, hormonal stimulation, various stresses, availability of energy within the cell and oxygen and mediates temporal control of cell growth via regulation of translation, transcription, ribosome biogenesis, nutrient transport, and autophagy. Coordinates cell size by regulating timing of G1-S cell cycle progression by mediating G1 cyclin/CDK activation as well as through destabilization of the SIC1 (P38634) CDK inhibitor. Inhibited by FKBP-rapamycin. - - - - - - psi-mi:"MI:0469"(IntAct) P32600(0)|P38873(0)|P41318(0)|Q08921(0) +CPX-1717 TORC2 complex TORC2|Target of rapamycin complex 2|TOR complex 2|TORC2 complex 559292 P32600(0)|P40061(0)|P41318(0)|P47041(0)|Q04749(0)|Q08236(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-2434993 GO:0031932(TORC2 complex)|GO:0030950(establishment or maintenance of actin cytoskeleton polarity)|GO:0031929(TOR signaling)|GO:0001558(regulation of cell growth)|GO:0004674(protein serine/threonine kinase activity)|GO:0005524(ATP binding) complex portal:CPX-1717(complex-primary)|rhea:RHEA:17989(identity)|intenz:2.7.11.1(identity)|rhea:RHEA:46608(identity)|pubmed:15689497(see-also)|pubmed:18215152(see-also) Serine/threonine-protein kinase signalling complex required for responses to starvation and stress conditions. Required for cytokinetic actomyosin ring (CAR) morphology and constriction, controls polarity of the actin cytoskeleton, and.regulates the timing and fidelity of cytokinesis. - - - - - - - psi-mi:"MI:0469"(IntAct) P32600(0)|P40061(0)|P41318(0)|P47041(0)|Q04749(0)|Q08236(0) +CPX-1718 GARP complex Golgi-associated retrograde protein complex|VFT complex|VPS fifty three complex|Vps fifty three tethering complex 559292 P36116(0)|P39904(0)|P47061(0)|Q12071(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-2435181 GO:0000938(GARP complex)|GO:0042147(retrograde transport, endosome to Golgi)|GO:0000149(SNARE binding)|GO:0090156(cellular sphingolipid homeostasis)|GO:0006623(protein targeting to vacuole) complex portal:CPX-1718(complex-primary) Tethering complex required for retrograde traffic from both the early and late endosomes to the Golgi during vesicle trafficking,sorting cargo for recycling to the plasma membrane or degradation in vacuoles. Links the vesicle through the SNARE proteins such as TGL1 (Q03322) to the Golgi, leading to membrane fusion between late Golgi and endosomal vesicles. Required for the recycling of amino-phospholipid flippases and cell wall synthesis proteins, thus playing a role in lipid homeostasis. Essential role in meiotic progression and spore formation. Belongs to the belongs to the family of CATCHR (complexes associated with tethering containing helical rods) complexes - - - - - - psi-mi:"MI:0469"(IntAct) P36116(0)|P39904(0)|P47061(0)|Q12071(0) +CPX-1719 Exomer complex CHS5/6 complex|Chs5-Chs6[all] complex|exomer 559292 P36122(0)|P40955(0)|Q05029(2)|Q08754(0)|Q12114(2) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-2435444 GO:0034044(exomer complex)|GO:0006893(Golgi to plasma membrane transport)|GO:0015031(protein transport) complex portal:CPX-1719(complex-primary)|wwpdb:4yg8(subset)|wwpdb:4in3(subset)|wwpdb:4WJW(subset) Cargo adaptor complex that mediates the sorting of specific plasma membrane proteins into vesicles at the trans-Golgi network. Forms a coat structure on vesicles involved in exocytosis of specific cargo proteins, including chitin synthase CHS3 (P29465), from the trans-Golgi network to the cell surface. Recruited by GTP-bound ARF1 (P11076). Mol. wt. = 1073kDa - - - - - - psi-mi:"MI:0469"(IntAct) P36122(0)|P40955(0)|Q05029(2)|Q08754(0)|Q12114(2) +CPX-1720 RNase H2 complex RNase H2 complex|Ribonuclease HII|RNase HII|Ribonuclease H2 559292 P53942(0)|Q05635(0)|Q12338(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-2435795 GO:0004523(RNA-DNA hybrid ribonuclease activity)|GO:0032299(ribonuclease H2 complex)|GO:0071667(DNA/RNA hybrid binding)|GO:0006298(mismatch repair) complex portal:CPX-1720(complex-primary)|intenz:3.1.26.4(identity)|pubmed:19228196(see-also) Specifically degrades the RNA species of RNA:DNA duplexes and removal of ribonucleotides misincorporated in genomic DNA, thus, preventing genomic instability and the accumulation of aberrant nucleic acid. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. - - - - - - - psi-mi:"MI:0469"(IntAct) P53942(0)|Q05635(0)|Q12338(0) +CPX-1721 Mitochondrial respiratory chain complex IV, COX5A variant Cytochrome C oxidase|Cytochrome c oxidase|NADH cytochrome c oxidase|Mitochondrial electron transport complex IV|Cytochrome a3|Ferrocytochrome c: oxygen oxidoreductase 559292 CHEBI:23378(3)|CHEBI:30413(2)|P00401(1)|P00410-PRO_0000006048(1)|P00420(1)|P00424-PRO_0000006097(1)|P00427-PRO_0000006108(1)|P04037-PRO_0000006114(1)|P04039-PRO_0000006173(2)|P07255-PRO_0000006076(1)|P10174(1)|P32799-PRO_0000006127(1)|Q01519(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-2435962 GO:0032592(integral component of mitochondrial membrane)|GO:0005751(mitochondrial respiratory chain complex IV)|GO:0004129(cytochrome-c oxidase activity)|GO:0006123(mitochondrial electron transport, cytochrome c to oxygen)|GO:0045333(cellular respiration) pubmed:7851399(see-also)|complex portal:CPX-1721(complex-primary)|rhea:RHEA:11436(identity)|intenz:7.1.1.9(identity)|pubmed:18975062(see-also) Key role in aerobic respiration, in which mitochondrial enzymes accept electrons from electron carriers reduced in glycolysis and the tricarboxylic acid cycle. A complex metalloprotein that transfers electrons from reduced cytochrome c to molecular oxygen and conserves the free energy released in this exergonic reaction by maintaining a transmembrane proton gradient which is utilized to drive the synthesis of ATP or ion transport across the membrane. The four protons consumed in the reduction of one oxygen molecule to water are taken from the mitochondrial matrix and, coupled to this reaction, four additional protons are translocated from the matrix to the intermembrane space. - Heterododecamer - - - - - psi-mi:"MI:0469"(IntAct) P00401(1)|P00410-PRO_0000006048(1)|P00420(1)|P00424-PRO_0000006097(1)|P00427-PRO_0000006108(1)|P04037-PRO_0000006114(1)|P04039-PRO_0000006173(2)|P07255-PRO_0000006076(1)|P10174(1)|P32799-PRO_0000006127(1)|Q01519(1) +CPX-1722 Mitochondrial respiratory chain complex IV, COX5B variant Cytochrome C oxidase|Cytochrome c oxidase|NADH cytochrome c oxidase|Cytochrome a3|Ferrocytochrome c: oxygen oxidoreductase|Mitochondrial electron transport complex IV 559292 CHEBI:23378(3)|CHEBI:30413(2)|P00401(1)|P00410-PRO_0000006048(1)|P00420(1)|P00425-PRO_0000006098(1)|P00427-PRO_0000006108(1)|P04037-PRO_0000006114(1)|P04039-PRO_0000006173(2)|P07255-PRO_0000006076(1)|P10174(1)|P32799-PRO_0000006127(1)|Q01519(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-2435962 GO:0045333(cellular respiration)|GO:0032592(integral component of mitochondrial membrane)|GO:0005751(mitochondrial respiratory chain complex IV)|GO:0004129(cytochrome-c oxidase activity)|GO:0006123(mitochondrial electron transport, cytochrome c to oxygen) complex portal:CPX-1722(complex-primary)|rhea:RHEA:11436(identity)|pubmed:18388202(see-also)|pubmed:2986105(see-also)|intenz:7.1.1.9(identity)|pubmed:18975062(see-also) Key role in aerobic respiration, in which mitochondrial enzymes accept electrons from electron carriers reduced in glycolysis and the tricarboxylic acid cycle. A complex metalloprotein that transfers electrons from reduced cytochrome c to molecular oxygen and conserves the free energy released in this exergonic reaction by maintaining a transmembrane proton gradient which is utilized to drive the synthesis of ATP or ion transport across the membrane. The four protons consumed in the reduction of one oxygen molecule to water are taken from the mitochondrial matrix and, coupled to this reaction, four additional protons are translocated from the matrix to the intermembrane space. This variant contains subunit 5B, in place of 5a, expression of which is switched on when the O2 concentration drops below a threshold of 0.5 uM O2, and results in a cytochrome-c oxidase which has a higher turnover rate for nitric oxide production. This thought to be a positive feedback mechanism in which mitochondrially produced nitric oxide induces expression of COX5b, whose protein product then functions to enhance the ability of Cytochrome c to produce nitric oxide in hypoxic/anoxic cells. - Heteroduodecamer - - - - - psi-mi:"MI:0469"(IntAct) P00401(1)|P00410-PRO_0000006048(1)|P00420(1)|P00425-PRO_0000006098(1)|P00427-PRO_0000006108(1)|P04037-PRO_0000006114(1)|P04039-PRO_0000006173(2)|P07255-PRO_0000006076(1)|P10174(1)|P32799-PRO_0000006127(1)|Q01519(1) +CPX-1726 PAF1 complex PAF1C|Cdc73/Paf1 complex|Polymerase Associated Factor 1 559292 P38351(0)|P38439(0)|P53064(0)|P89105(0)|Q06697(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-2436762 GO:0016571(histone methylation)|GO:0016593(Cdc73/Paf1 complex)|GO:0006368(transcription elongation from RNA polymerase II promoter) complex portal:CPX-1726(complex-primary) A multifunctional complex involved in many aspects of RNA polymerase II (Pol II) transcriptional regulation, including transcriptional elongation, 3-prime-terminal end processing, and histone modification. Role in 3-prime end formation of mRNAs, required for the recruitment of cleavage and polyadenylation factors CFT1 and PCF11 to RNA polymerase II. Required for activation of the RAD6/UBC2-BRE1 ubiquitin ligase complex, which ubiquitinates histone H2B to form H2BK123ub1. Also required for the methylation of histone H3 by the COMPASS complex (CPX-1039) to form H3K4me, by SET2 to form H3K36me, and by DOT1 to form H3K79me. None of the PAF1 complex components are essential for the viability of S. cerevisiae, but functional loss of the complex causes diverse phenotypes including sensitivity to cellular stresses, which is linked to defects in chromatin and transcriptional regulation. - - - - - - psi-mi:"MI:0469"(IntAct) P38351(0)|P38439(0)|P53064(0)|P89105(0)|Q06697(0) +CPX-1730 Peroxisomal ABC transporter complex PXA1-PXA2 PXA1-PXA2|Pxa1p/Pxa2p heterodimer|Pat1-Pat2|Pat2-Pal1 559292 P34230(0)|P41909(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-2464666 GO:0005324(long-chain fatty acid transporter activity)|GO:0005779(integral component of peroxisomal membrane)|GO:0043190(ATP-binding cassette (ABC) transporter complex)|GO:0015910(long-chain fatty acid import into peroxisome)|GO:0042626(ATPase-coupled transmembrane transporter activity)|GO:0005524(ATP binding) complex portal:CPX-1730(complex-primary)|pubmed:22493507(see-also)|pubmed:17039367(see-also) Peroxisomal ABC transporter involved in transmembrane transport of long chain fatty acids, most likely in their CoA ester form, into the peroxisomal matrix prior to beta-oxidation. Very long chain acyl-CoA esters are hydrolyzed by the PXA1-PXA2 complex prior to the transport of their fatty acid portion into the peroxisomes with the CoA being released into the cytoplasm. - - - - - - - psi-mi:"MI:0469"(IntAct) P34230(0)|P41909(0) +CPX-1731 CTF18-RFC complex Ctf18-replication factor C complex|Ctf18 cohesion establishment complex|Ctf18 RFC-like complex 559292 P25559(0)|P38251(0)|P38629(0)|P38877(0)|P40339(0)|P40348(0)|P49956(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-963534 GO:0031390(Ctf18 RFC-like complex)|GO:0007064(mitotic sister chromatid cohesion)|GO:0003677(DNA binding) complex portal:CPX-1731(complex-primary)|pubmed:11389843(see-also) Required for efficient establishment of chromosome cohesion during S-phase and may load or unload POL30/PCNA. During a clamp loading circle, the RFC:clamp complex binds to DNA and the recognition of the double-stranded/single-stranded junction stimulates ATP hydrolysis by RFC. The complex presumably provides bipartite ATP sites in which one subunit supplies a catalytic site for hydrolysis of ATP bound to the neighboring subunit. Dissociation of RFC from the clamp leaves the clamp encircling DNA. - - - - - - - psi-mi:"MI:0469"(IntAct) P25559(0)|P38251(0)|P38629(0)|P38877(0)|P40339(0)|P40348(0)|P49956(0) +CPX-1732 Ku70:Ku80 complex KU complex|YKU70/80 complex|Ku70-Ku80 complex 559292 P32807(1)|Q04437(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-787093 GO:0043564(Ku70:Ku80 complex)|GO:0070034(telomerase RNA binding)|GO:0000723(telomere maintenance)|GO:0000725(recombinational repair)|GO:0006303(double-strand break repair via nonhomologous end joining)|GO:0042162(telomeric DNA binding)|GO:0003684(damaged DNA binding)|GO:0003678(DNA helicase activity)|GO:0005524(ATP binding) complex portal:CPX-1732(complex-primary)|wwpdb:5y58(identity) Single-stranded DNA-dependent 3-prime to 5-prime ATP-dependent helicase complex which binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. Required for non-homologous end joining DNA double stranded break repair. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Appears to have a role in recruitment of telomerase and CDC13 to the telomere and the subsequent telomere elongation. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. Forms a dyad-symmetrical molecule with a preformed ring that encircles duplex DNA. The binding site can cradle two full turns of DNA while encircling only the central 3-4 base pairs. A broken DNA end is able to thread through the channel formed by the complex, whilst unbroken DNA cannot bind in this manner, ensuring exquisitely specific DSB recognition. Heterodimer - - - - - psi-mi:"MI:0469"(IntAct) P32807(1)|Q04437(1) +CPX-1733 NOC1-NOC2 pre-ribosome maturation complex Noc1p-Noc2p|Mak21-Noc2 complex 559292 P39744(0)|Q12176(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-1166276 GO:0030690(Noc1p-Noc2p complex)|GO:0000027(ribosomal large subunit assembly)|GO:0005730(nucleolus) complex portal:CPX-1733(complex-primary)|pubmed:11371346(see-also) Associates with 90S and 66S pre-ribosomes and is enriched in the nucleolus. Required for for intranuclear movement and maturation of ribosomal precursor particles. - - - - - - - psi-mi:"MI:0469"(IntAct) P39744(0)|Q12176(0) +CPX-1734 NOC2-NOC3 pre-ribosome maturation complex Noc2p/Noc3p|Noc2p-Noc3p 559292 P39744(0)|Q07896(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-1166282 GO:0030691(Noc2p-Noc3p complex)|GO:0000027(ribosomal large subunit assembly)|GO:0005654(nucleoplasm) complex portal:CPX-1734(complex-primary)|pubmed:11371346(see-also) Associates with 66S pre-ribosomes and is mainly nucleoplasmic. Required for intranuclear movement and maturation of ribosomal precursor particles. - - - - - - - psi-mi:"MI:0469"(IntAct) P39744(0)|Q07896(0) +CPX-1735 NOP14-NOC4 complex Noc4-Nop14p complex 559292 Q06512(0)|Q99207(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-1165775 GO:0030692(Noc4p-Nop14p complex)|GO:0000028(ribosomal small subunit assembly)|GO:0005634(nucleus) complex portal:CPX-1735(complex-primary) required for biogenesis of the small ribosomal subunit formation and subsequent export to the cytoplasm.The nucleolar localization of Nop14 is dependent on Noc4. - - - - - - - psi-mi:"MI:0469"(IntAct) Q06512(0)|Q99207(0) +CPX-1738 Phenylalanyl-tRNA synthetase complex Phenylalanyl-tRNA synthetase, cytoplasmic|Phenylalanine--tRNA ligase|Phenylalanine-tRNA ligase complex|SYFA-SYFB complex 559292 P15624(2)|P15625(2) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-809760 GO:0000049(tRNA binding)|GO:0004826(phenylalanine-tRNA ligase activity)|GO:0005524(ATP binding)|GO:0006432(phenylalanyl-tRNA aminoacylation)|GO:0009328(phenylalanine-tRNA ligase complex) complex portal:CPX-1738(complex-primary)|rhea:RHEA:19413(identity)|intenz:6.1.1.20(identity) Catalyses the esterificaion of phenylalanine to its cognate tRNA with the concomitant hydrolysis of ATP. The activated amino acid is transferred to the 2-OH group of a phenylalanine-accepting tRNA. The N-terminal domain of each beta subunit (residues l-172) contains the major tRNA-Phe binding sites. Heterotetramer - - - - - psi-mi:"MI:0469"(IntAct) P15624(2)|P15625(2) +CPX-1739 Mannosyl phosphorylinositol ceramide synthase SUR1-CSG2 SUR1:CSG2|CSG1-CSG2|Csg1p-Csg2p 559292 P33300(0)|P35206(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-2476987 GO:0000030(mannosyltransferase activity)|GO:0031501(mannosyltransferase complex)|GO:0005794(Golgi apparatus)|GO:0006676(mannosyl diphosphorylinositol ceramide metabolic process) complex portal:CPX-1739(complex-primary)|pubmed:12954640(see-also)|intenz:2.4(identity) Catalyzes the addition of mannosyl to phosphorylinositol ceramide, and essential step in the synthesis of mannosylinositol phosphorylceramide. Function in the Golgi. Preferentially active against IPC-B and IPC-C in comparison with Mannosyl phosphorylinositol ceramide synthase CSH1-CSG2 (CPX-1740). - - - - - - - psi-mi:"MI:0469"(IntAct) P33300(0)|P35206(0) +CPX-1740 Mannosyl phosphorylinositol ceramide synthase CSH1-CSG2 CSH1-CSG2|Csh1p-Csg2p 559292 P35206(0)|P38287(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0000030(mannosyltransferase activity)|GO:0031501(mannosyltransferase complex)|GO:0006676(mannosyl diphosphorylinositol ceramide metabolic process)|GO:0005794(Golgi apparatus) complex portal:CPX-1740(complex-primary)|intact:EBI-2476998(identity)|intenz:2.4(identity) Catalyzes the addition of mannosyl to phosphorylinositol ceramide, and essential step in the synthesis of mannosylinositol phosphorylceramide. Function in the Golgi. Less active against IPC-B and IPC-C in comparison with Mannosyl phosphorylinositol ceramide synthase SUR1-CSG2 (CPX-1739). - - - - - - - psi-mi:"MI:0469"(IntAct) P35206(0)|P38287(0) +CPX-1741 Endonuclease SceI endo.SceI|endoSceI 559292 P0CS90(1)|P12294(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-983180 GO:0004520(endodeoxyribonuclease activity)|GO:1905347(endodeoxyribonuclease complex)|GO:0000018(regulation of DNA recombination)|GO:0032042(mitochondrial DNA metabolic process)|GO:0005739(mitochondrion) complex portal:CPX-1741(complex-primary)|intenz:3.1.21(identity) Mitochondrial endonuclease which cleaves mitochondrial DNA during the process of mitochondrial fusion, when haploid cells are mated to form zygotic cells, to induce genetic recombination among the heterogeneous mitochondrial DNAs inherited from the parents. ENS2 is completely absent in the mitochondrial genome of strain S288c. Heterodimer - - - - - psi-mi:"MI:0469"(IntAct) P0CS90(1)|P12294(1) +CPX-1742 tRNA-specific adenosine-34 deaminase complex tRNA-specific adenosine deaminase|tRNA A:34 deaminase|tRNA:A34 deaminase|Tad2p/ADAT2-Tad3p/ADAT3 complex|Tad2p-Tad3p 559292 P47058(1)|Q9URQ3(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-2478939 GO:0052718(tRNA-specific adenosine-34 deaminase complex)|GO:0002100(tRNA wobble adenosine to inosine editing)|GO:0052717(tRNA-specific adenosine-34 deaminase activity) complex portal:CPX-1742(complex-primary)|intenz:3.5.4.33(identity)|rhea:RHEA:43168(identity)|pubmed:23633143(see-also) Deaminates adenosine-34 (wobble position) to inosine in double-stranded tRNA. When present at the wobble position, inosine can pair degenerately with uracil, cytosine, or adenosine, enabling a single tRNA to recognize up to three different codons. Complex m.w.=70kDa Heterodimer - - - - - psi-mi:"MI:0469"(IntAct) P47058(1)|Q9URQ3(1) +CPX-1743 Ribosome-associated complex - 559292 P32527(1)|P38788(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-2479003 GO:0043022(ribosome binding)|GO:0051082(unfolded protein binding)|GO:0051083('de novo' cotranslational protein folding)|GO:0006450(regulation of translational fidelity)|GO:0006457(protein folding) complex portal:CPX-1743(complex-primary) Chaperone complex involved in regulation of accurate translation termination and in folding or maintaining nascent polypeptides in a folding-competent state. RAC stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones SSB1/SSB2 that bind to the nascent polypeptide chain. Complex m.w.=126,000 Da Heterodimer - - - - - psi-mi:"MI:0469"(IntAct) P32527(1)|P38788(1) +CPX-1744 Mitochondrial sorting and assembly machinery complex TOB complex|Topogenesis of Outer-membrane beta-barrel proteins|Sorting and Assembly Machinery complex|SAM complex 559292 P14693(0)|P50110(0)|P53969(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-2491910 GO:0030150(protein import into mitochondrial matrix)|GO:0001401(mitochondrial sorting and assembly machinery complex)|GO:0005739(mitochondrion) complex portal:CPX-1744(complex-primary) Involved in the membrane assembly of mitochondrial beta-barrel proteins, which are synthesized on cytosolic ribosomes and recognized initially by the import receptors of the translocase of the mitochondrial outer membrane (TOM complex CPX-474). They are then translocated across the outer membrane via the general-import pore of the TOM complex and relayed to the SAM complex. - - - - - - - psi-mi:"MI:0469"(IntAct) P14693(0)|P50110(0)|P53969(0) +CPX-1786 Dsl1 tethering complex - 559292 P33891(0)|P53847(0)|Q12745(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-2507582 GO:0006890(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|GO:0000149(SNARE binding)|GO:0070939(Dsl1/NZR complex) complex portal:CPX-1786(complex-primary)|pubmed:19151722(see-also)|pubmed:21550981(see-also) Multisubunit tethering complex essential for the retrograde traffic of COPI-coated vesicles from the Golgi to the ER. Binds to individual SNAREs via their N-terminal regulatory domains and also to assembled SNARE complexes, and is capable of accelerating SNARE complex assembly. SNARE binding mediates fusion of COPI vesicles with the endoplasmic reticulum. - - - - - - - psi-mi:"MI:0469"(IntAct) P33891(0)|P53847(0)|Q12745(0) +CPX-1787 Nem1-Spo7 phosphatase complex Nem1p-Spo7p complex 559292 P18410(0)|P38757(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-2530885 GO:0004721(phosphoprotein phosphatase activity)|GO:0071595(Nem1-Spo7 phosphatase complex)|GO:0006998(nuclear envelope organization) complex portal:CPX-1787(complex-primary)|rhea:RHEA:20629(identity)|rhea:RHEA:47004(identity)|intenz:3.1.3.16(identity) Phosphatase complex with an essential role in formation of a spherical nucleus and meiotic division. Dephosphorylates PAH1 (P32567), a critical factor in coordinating phospholipid biosynthesis at the nuclear/ER membrane with nuclear growth during the cell cycle. NEM1-SPO7-mediated regulation of membrane biogenesis is required to promote mitophagy. - - - - - - - psi-mi:"MI:0469"(IntAct) P18410(0)|P38757(0) +CPX-1792 THO complex THO transcription elongation complex 559292 O13539(0)|P17629(0)|P33441(0)|P53552(0)|P53851(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0000347(THO complex)|GO:0003677(DNA binding)|GO:0006368(RNA elongation from RNA polyme) complex portal:CPX-1792(complex-primary)|intact:EBI-2531086(identity) Functions at the interface between transcription and mRNA export via its interaction with SUB2 in the TREX complex (CPX-1793). Recruited to transcribed genes and moves along the gene with the elongating polymerase during transcription. THO is important for stabilizing nascent RNA in the RNA polymerase II elongation complex by preventing formation of DNA:RNA hybrids behind the elongating polymerase. - - - - - - - psi-mi:"MI:0469"(IntAct) O13539(0)|P17629(0)|P33441(0)|P53552(0)|P53851(0) +CPX-1793 TREX complex TRanscription/EXport complex|TREX/THO complex 559292 O13539(0)|P17629(0)|P33441(0)|P53552(0)|P53851(0)|Q07478(0)|Q12159(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-2531141 GO:0000346(transcription export complex)|GO:0006406(mRNA export from nucleus)|GO:0003677(DNA binding)|GO:0003729(mRNA binding)|GO:0006368(transcription elongation from RNA polymerase II promoter) complex portal:CPX-1793(complex-primary)|pubmed:11979277(see-also)|intenz:3.6.4.13(identity)|rhea:RHEA:13065(identity)|wwpdb:5SUP(subset)|pubmed:28059701(see-also) Couples transcription elongation by RNA polymerase II to mRNA export. Associates with the polymerase and travels with it along the length of the transcribed gene. TREX is composed of the THO transcription elongation complex (CPX-1792) as well as other proteins that couple THO to mRNA export proteins. - - - - - - - psi-mi:"MI:0469"(IntAct) O13539(0)|P17629(0)|P33441(0)|P53552(0)|P53851(0)|Q07478(0)|Q12159(0) +CPX-1892 Mitochondrial inner membrane peptidase complex IMP complex 559292 P28627(0)|P46972(0)|Q05676(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0042720(mitochondrial inner membrane peptidase complex)|GO:0004175(endopeptidase activity)|GO:0006465(signal peptide processing)|GO:0005743(mitochondrial inner membrane) complex portal:CPX-1892(complex-primary)|intenz:3.4.21(identity)|intact:EBI-3401322(secondary-ac) Processes certain precursor proteins that are exported from the matrix into the inner membrane or the intermembrane space. The two IMP subunits are associated with the inner membrane, and their catalytic sites are exposed to the intermembrane space. The IMP1 and IMP2 proteins both display proteolytic activity and have non-overlapping substrate specificities. IMP1 has been shown to catalyse the maturation of cytochrome oxidase subunit 2, cytochrome b2 and the 32-kDa form of NADH-dependent cytochrome b5 reductase, while IMP2 participates in the second processing step during the maturation of cytochrome c1. SOM1 appears to functions as a molecular chaperone, which binds to specific substrates and directs them to the catalytic site. - - - - - - - psi-mi:"MI:0469"(IntAct) P28627(0)|P46972(0)|Q05676(0) +CPX-5304 Endoplasmic reticulum snare complex UFE1-USE1-SEC20-SEC22 - 559292 P22214(1)|P28791(1)|P41834(1)|P53146(1) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) intact:EBI-2509473 GO:0031201(SNARE complex)|GO:0071458(integral component of cytoplasmic side of endoplasmic reticulum membrane)|GO:0006890(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|GO:0048279(vesicle fusion with endoplasmic reticulum)|GO:0012508(Golgi to ER transport vesicle membrane) pubmed:16912714(see-also)|pubmed:20521906(see-also)|pubmed:24119662(see-also)|pubmed:20005805(see-also)|pubmed:9214619(see-also)|complex portal:CPX-5304(complex-primary) SNARE complex required for the fusion of retrograde transport vesicles with the endoplasmic reticulum. Mediates membrane fusion through the spontaneous assembly of four complementary SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) motifs. SNAREs bind to each other in-trans, that is, with SNAREs anchored in each apposed tethered membrane. The assembly process leads to a tight connection between the fusing membranes and initiates membrane fusion. When interacting sets of SNAREs are combined, the SNARE motifs spontaneously associate to form elongated coiled coils of four intertwined, parallel alpha-helices (a SNAREpin), with each helix being provided by a different SNARE motif. The centre of the bundle contains 16 stacked layers of interacting side chains. These layers are largely hydrophobic, except for a central 0 layer that contains three highly conserved glutamine (Q) residues and one highly conserved arginine (R) residue. SNARE motifs are classified into Qa-, Qb-, Qc- and R-SNAREs and the hetero-oligomeric SNARE complexes that drive membrane fusion require that each parallel four-helix bundles is invariant and contains one each of the Qa-, Qb-, Qc- and R-SNAREs. Heterotetramer - - - - - psi-mi:"MI:0486"(UniProt) P22214(1)|P28791(1)|P41834(1)|P53146(1) +CPX-5321 Endosomal SNARE complex TLG2-VTI1-TLG1-SNC2 - 559292 P33328(1)|Q03322(1)|Q04338(1)|Q08144(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-25419736 GO:0031201(SNARE complex)|GO:0042147(retrograde transport, endosome to Golgi)|GO:0006897(endocytosis)|GO:0031303(integral component of endosome membrane)|GO:0048280(vesicle fusion with Golgi apparatus)|GO:0030173(integral component of Golgi membrane)|GO:0006906(vesicle fusion)|GO:0016021(integral component of membrane) pubmed:16912714(see-also)|pubmed:11739407(see-also)|complex portal:CPX-5321(complex-primary)|pubmed:9427746(see-also)|pubmed:9565594(see-also)|pubmed:20521906(see-also)|pubmed:24119662(see-also) SNARE complex required for the fusion of endosomal vesicles with the trans-Golgi network. Mediates membrane fusion through the spontaneous assembly of four complementary SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) motifs. SNAREs bind to each other in-trans, that is, with SNAREs anchored in each apposed tethered membrane. The assembly process leads to a tight connection between the fusing membranes and initiates membrane fusion. When interacting sets of SNAREs are combined, the SNARE motifs spontaneously associate to form elongated coiled coils of four intertwined, parallel alpha-helices (a SNAREpin), with each helix being provided by a different SNARE motif. The centre of the bundle contains 16 stacked layers of interacting side chains. These layers are largely hydrophobic, except for a central 0 layer that contains three highly conserved glutamine (Q) residues and one highly conserved arginine (R) residue. SNARE motifs are classified into Qa-, Qb-, Qc- and R-SNAREs and the hetero-oligomeric SNARE complexes that drive membrane fusion require that each parallel four-helix bundles is invariant and contains one each of the Qa-, Qb-, Qc- and R-SNAREs. Heterotetramer - - - - - psi-mi:"MI:0486"(UniProt) P33328(1)|Q03322(1)|Q04338(1)|Q08144(1) +CPX-5322 Endosomal SNARE complex TLG2-VTI1-TLG1-SNC1 - 559292 P31109(1)|Q03322(1)|Q04338(1)|Q08144(1) ECO:0005546(biological system reconstruction evidence based on paralogy evidence used in manual assertion) - GO:0031201(SNARE complex)|GO:0042147(retrograde transport, endosome to Golgi)|GO:0006897(endocytosis)|GO:0031303(integral component of endosome membrane)|GO:0048280(vesicle fusion with Golgi apparatus)|GO:0030173(integral component of Golgi membrane)|GO:0006906(vesicle fusion)|GO:0016021(integral component of membrane) complex portal:CPX-5321(inferred-from)|pubmed:16912714(see-also)|pubmed:11739407(see-also)|complex portal:CPX-5322(complex-primary)|pubmed:9427746(see-also)|pubmed:24119662(see-also)|pubmed:20521906(see-also) SNARE complex required for the fusion of endosomal vesicles with the trans-Golgi network. Mediates membrane fusion through the spontaneous assembly of four complementary SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) motifs. SNAREs bind to each other in-trans, that is, with SNAREs anchored in each apposed tethered membrane. The assembly process leads to a tight connection between the fusing membranes and initiates membrane fusion. When interacting sets of SNAREs are combined, the SNARE motifs spontaneously associate to form elongated coiled coils of four intertwined, parallel alpha-helices (a SNAREpin), with each helix being provided by a different SNARE motif. The centre of the bundle contains 16 stacked layers of interacting side chains. These layers are largely hydrophobic, except for a central 0 layer that contains three highly conserved glutamine (Q) residues and one highly conserved arginine (R) residue. SNARE motifs are classified into Qa-, Qb-, Qc- and R-SNAREs and the hetero-oligomeric SNARE complexes that drive membrane fusion require that each parallel four-helix bundles is invariant and contains one each of the Qa-, Qb-, Qc- and R-SNAREs. Heterotetramer - - - - - psi-mi:"MI:0486"(UniProt) P31109(1)|Q03322(1)|Q04338(1)|Q08144(1) +CPX-5341 DBF20-MOB1 kinase complex DBF2-MOB1 559292 P32328(1)|P40484(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-25610693 GO:0004674(protein serine/threonine kinase activity)|GO:0006468(protein phosphorylation)|GO:0032465(regulation of cytokinesis)|GO:0010458(exit from mitosis)|GO:1902554(serine/threonine protein kinase complex) intenz:2.7.11.1(identity)|rhea:RHEA:17989(identity)|rhea:RHEA:46608(identity)|complex portal:CPX-5341(complex-primary)|pubmed:9528782(see-also)|pubmed:22573892(see-also) Probable role in exit from mitosis during the cell cycle. By parology to DBF2-MOB1 kinase complex (CPX-1683), the complex once activated, translocates to the nucleus where it phosphorylates an unknown protein to dislodge CDC14 (Q00684) from NET1 (P47035), resulting in diffusion of CDC14 throughout the nucleus. Phosphorylates CDC14 on several sites that flank the C-terminal nuclear localization signal (NLS) sequences, thereby inhibiting the NLS. Because of this, phosphorylated CDC14 molecules that escape to the cytoplasm cannot efficiently return to the nucleus and dephosphorylate substrates such as CDH1 (P53197) and SWI5 (P08153). Phosphorylates chitin synthase CHS2 (P14180) to regulate cytokinesis. This complex is paralogous to the DBF2-MOB1 kinase complex (CPX-1683) and is assumed to have the same functionality however DBF2 (P22204) accounts for the bulk of the activity, with DBF20 playing a minor role. A dbf2/dbf20 double deletion is embryonically lethal. Heterodimer - - - - - psi-mi:"MI:0486"(UniProt) P32328(1)|P40484(1) +CPX-1887 Vacuolar SNARE complex VAM3-VTI1-VAM7-YKT6 Soluble N-ethylmaleimide-sensitive factor (NSF) attachment receptor complex 559292 P32912(1)|P36015(1)|Q04338(1)|Q12241(1) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0097637(integral component of autophagosome membrane)|GO:0061911(amphisome-lysosome fusion)|GO:0006886(intracellular protein transport)|GO:0006906(vesicle fusion)|GO:0031166(integral component of vacuolar membrane)|GO:0031201(SNARE complex) pubmed:16912714(see-also)|pubmed:30097515(see-also)|pubmed:30097514(see-also)|pubmed:20521906(see-also)|complex portal:CPX-1887(complex-primary)|intact:EBI-2927908(secondary-ac)|pubmed:12802061(see-also)|pubmed:24119662(see-also) SNARE complex required for autophagosome-vacuole fusion. Mediates membrane fusion through the spontaneous assembly of four complementary SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) motifs. SNAREs bind to each other in-trans, that is, with SNAREs anchored in each apposed tethered membrane. The assembly process leads to a tight connection between the linked membranes and initiates membrane fusion. When interacting sets of SNAREs are combined, the SNARE motifs spontaneously associate to form elongated coiled coils of four intertwined, parallel alpha-helices (a SNAREpin), with each helix being provided by a different SNARE motif. The centre of the bundle contains 16 stacked layers of interacting side chains. These layers are largely hydrophobic, except for a central 0 layer that contains three highly conserved glutamine (Q) residues and one highly conserved arginine (R) residue. SNARE motifs are classified into Qa-, Qb-, Qc- and R-SNAREs and the hetero-oligomeric SNARE complexes that drive membrane fusion require that each parallel four-helix bundles is invariant and contains one each of the Qa-, Qb-, Qc- and R-SNAREs. Heterotetramer - - - - - psi-mi:"MI:0486"(UniProt) P32912(1)|P36015(1)|Q04338(1)|Q12241(1) +CPX-5401 Vacuolar SNARE complex VAM3-VTI1-VAM7-NYV1 Soluble N-ethylmaleimide-sensitive factor (NSF) attachment receptor complex 559292 P32912(1)|Q04338(1)|Q12241(1)|Q12255(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-15637277 GO:0007036(vacuolar calcium ion homeostasis)|GO:0031166(integral component of vacuolar membrane)|GO:0006886(intracellular protein transport)|GO:0031201(SNARE complex)|GO:0042144(vacuole fusion, non-autophagic) pubmed:17502611(see-also)|pubmed:16912714(see-also)|pubmed:24119662(see-also)|pubmed:20521906(see-also)|complex portal:CPX-5401(complex-primary) SNARE complex required for homotypic vacuole fusion and is important for vacuole formation. SNARE assembly also appears to promote Ca2+ release from the vacuole lumen. Mediates membrane fusion through the spontaneous assembly of four complementary SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) motifs. SNAREs bind to each other in-trans, that is, with SNAREs anchored in each apposed tethered membrane. The assembly process leads to a tight connection between the linked membranes and initiates membrane fusion. When interacting sets of SNAREs are combined, the SNARE motifs spontaneously associate to form elongated coiled coils of four intertwined, parallel alpha-helices (a SNAREpin), with each helix being provided by a different SNARE motif. The centre of the bundle contains 16 stacked layers of interacting side chains. These layers are largely hydrophobic, except for a central 0 layer that contains three highly conserved glutamine (Q) residues and one highly conserved arginine (R) residue. SNARE motifs are classified into Qa-, Qb-, Qc- and R-SNAREs and the hetero-oligomeric SNARE complexes that drive membrane fusion require that each parallel four-helix bundles is invariant and contains one each of the Qa-, Qb-, Qc- and R-SNAREs. Homotetramer - - - - - psi-mi:"MI:0486"(UniProt) P32912(1)|Q04338(1)|Q12241(1)|Q12255(1) +CPX-5421 Endosomal SNARE complex PEP12-VTI1-SYN8-YKT6 - 559292 P31377(1)|P32854(1)|P36015(1)|Q04338(1) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0006886(intracellular protein transport)|GO:0031201(SNARE complex)|GO:0031303(integral component of endosome membrane)|GO:0006895(Golgi to endosome transport)|GO:0030173(integral component of Golgi membrane)|GO:0048210(Golgi vesicle fusion to target membrane) complex portal:CPX-5421(complex-primary)|pubmed:24119662(see-also)|pubmed:12453154(see-also)|pubmed:16912714(see-also)|pubmed:20521906(see-also) SNARE complex required for transport from the Golgi to endosomes. Mediates membrane fusion through the spontaneous assembly of four complementary SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) motifs. SNAREs bind to each other in-trans, that is, with SNAREs anchored in each apposed tethered membrane. The assembly process leads to a tight connection between the linked membranes and initiates membrane fusion. When interacting sets of SNAREs are combined, the SNARE motifs spontaneously associate to form elongated coiled coils of four intertwined, parallel alpha-helices (a SNAREpin), with each helix being provided by a different SNARE motif. The centre of the bundle contains 16 stacked layers of interacting side chains. These layers are largely hydrophobic, except for a central 0 layer that contains three highly conserved glutamine (Q) residues and one highly conserved arginine (R) residue. SNARE motifs are classified into Qa-, Qb-, Qc- and R-SNAREs and the hetero-oligomeric SNARE complexes that drive membrane fusion require that each parallel four-helix bundles is invariant and contains one each of the Qa-, Qb-, Qc- and R-SNAREs. Heterotetramer - - - - - psi-mi:"MI:0486"(UniProt) P31377(1)|P32854(1)|P36015(1)|Q04338(1) +CPX-5422 Endosomal SNARE complex PEP12-VTI1-TLG1-YKT6 - 559292 P32854(1)|P36015(1)|Q03322(1)|Q04338(1) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0031303(integral component of endosome membrane)|GO:0006886(intracellular protein transport)|GO:0031201(SNARE complex)|GO:0006895(Golgi to endosome transport)|GO:0048210(Golgi vesicle fusion to target membrane)|GO:0030173(integral component of Golgi membrane) pubmed:24119662(see-also)|complex portal:CPX-5422(complex-primary)|pubmed:12453154(see-also)|pubmed:16912714(see-also)|pubmed:20521906(see-also) SNARE complex required for transport from the Golgi to endosomes. Mediates membrane fusion through the spontaneous assembly of four complementary SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) motifs. SNAREs bind to each other in-trans, that is, with SNAREs anchored in each apposed tethered membrane. The assembly process leads to a tight connection between the linked membranes and initiates membrane fusion. When interacting sets of SNAREs are combined, the SNARE motifs spontaneously associate to form elongated coiled coils of four intertwined, parallel alpha-helices (a SNAREpin), with each helix being provided by a different SNARE motif. The centre of the bundle contains 16 stacked layers of interacting side chains. These layers are largely hydrophobic, except for a central 0 layer that contains three highly conserved glutamine (Q) residues and one highly conserved arginine (R) residue. SNARE motifs are classified into Qa-, Qb-, Qc- and R-SNAREs and the hetero-oligomeric SNARE complexes that drive membrane fusion require that each parallel four-helix bundles is invariant and contains one each of the Qa-, Qb-, Qc- and R-SNAREs. Heterotetramer - - - - - psi-mi:"MI:0486"(UniProt) P32854(1)|P36015(1)|Q03322(1)|Q04338(1) +CPX-5423 Endosomal SNARE complex PEP12-VTI1-TLG1-SNC1 - 559292 P31109(1)|P32854(1)|Q03322(1)|Q04338(1) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0006886(intracellular protein transport)|GO:0031201(SNARE complex)|GO:0031303(integral component of endosome membrane)|GO:0006895(Golgi to endosome transport)|GO:0048210(Golgi vesicle fusion to target membrane)|GO:0030173(integral component of Golgi membrane) pubmed:24119662(see-also)|complex portal:CPX-5423(complex-primary)|pubmed:16912714(see-also)|pubmed:20521906(see-also)|pubmed:12453154(see-also) SNARE complex required for transport from the Golgi to endosomes. Mediates membrane fusion through the spontaneous assembly of four complementary SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) motifs. SNAREs bind to each other in-trans, that is, with SNAREs anchored in each apposed tethered membrane. The assembly process leads to a tight connection between the linked membranes and initiates membrane fusion. When interacting sets of SNAREs are combined, the SNARE motifs spontaneously associate to form elongated coiled coils of four intertwined, parallel alpha-helices (a SNAREpin), with each helix being provided by a different SNARE motif. The centre of the bundle contains 16 stacked layers of interacting side chains. These layers are largely hydrophobic, except for a central 0 layer that contains three highly conserved glutamine (Q) residues and one highly conserved arginine (R) residue. SNARE motifs are classified into Qa-, Qb-, Qc- and R-SNAREs and the hetero-oligomeric SNARE complexes that drive membrane fusion require that each parallel four-helix bundles is invariant and contains one each of the Qa-, Qb-, Qc- and R-SNAREs. Heterotetramer - - - - - psi-mi:"MI:0486"(UniProt) P31109(1)|P32854(1)|Q03322(1)|Q04338(1) +CPX-5424 Endosomal SNARE complex PEP12-VTI1-SYN8-SNC1 - 559292 P31109(1)|P31377(1)|P32854(1)|Q04338(1) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0006886(intracellular protein transport)|GO:0031201(SNARE complex)|GO:0031303(integral component of endosome membrane)|GO:0006895(Golgi to endosome transport)|GO:0030173(integral component of Golgi membrane)|GO:0048210(Golgi vesicle fusion to target membrane) pubmed:24119662(see-also)|complex portal:CPX-5424(complex-primary)|pubmed:12453154(see-also)|pubmed:16912714(see-also)|pubmed:20521906(see-also) SNARE complex required for transport from the Golgi to endosomes. Mediates membrane fusion through the spontaneous assembly of four complementary SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) motifs. SNAREs bind to each other in-trans, that is, with SNAREs anchored in each apposed tethered membrane. The assembly process leads to a tight connection between the linked membranes and initiates membrane fusion. When interacting sets of SNAREs are combined, the SNARE motifs spontaneously associate to form elongated coiled coils of four intertwined, parallel alpha-helices (a SNAREpin), with each helix being provided by a different SNARE motif. The centre of the bundle contains 16 stacked layers of interacting side chains. These layers are largely hydrophobic, except for a central 0 layer that contains three highly conserved glutamine (Q) residues and one highly conserved arginine (R) residue. SNARE motifs are classified into Qa-, Qb-, Qc- and R-SNAREs and the hetero-oligomeric SNARE complexes that drive membrane fusion require that each parallel four-helix bundles is invariant and contains one each of the Qa-, Qb-, Qc- and R-SNAREs. Heterotetramer - - - - - psi-mi:"MI:0486"(UniProt) P31109(1)|P31377(1)|P32854(1)|Q04338(1) +CPX-5441 SPO16:ZIP2 - 559292 P17122(1)|P53061(1) ECO:0000353(physical interaction evidence used in manual assertion) - GO:0000406(double-strand/single-strand DNA junction binding)|GO:0007131(reciprocal meiotic recombination) pubmed:29440262(see-also)|complex portal:CPX-5441(complex-primary)|pubmed:30566683(see-also)|wwpdb:6BZF(identity)|wwpdb:6BZG(identity) Binds both single-stranded and double-stranded DNA; prefers nicked double-stranded DNA and Holliday Junction DNA. Lacks endonuclease activity and may act as a scaffolding complex stabilizing D-loop intermediates - Heterodimer - - - - - psi-mi:"-"(Saccharomyces Genome Database) P17122(1)|P53061(1) +CPX-5442 ZZS complex Zip2-Zip4-Spo16 complex 559292 P17122(1)|P40511(0)|P53061(1) ECO:0000353(physical interaction evidence used in manual assertion) - GO:0000406(double-strand/single-strand DNA junction binding)|GO:0007131(reciprocal meiotic recombination) pubmed:30566683(see-also)|complex portal:CPX-5442(complex-primary)|pubmed:29440262(see-also) Complex that preferentially binds double-strand break hot spots during meiosis; ZIP2 is critical for complex binding to chromosomes - - - - - - - psi-mi:"-"(Saccharomyces Genome Database) P17122(1)|P40511(0)|P53061(1) +CPX-5461 Endosomal SNARE complex PEP12-VTI1-SYN8-SNC2 - 559292 P31377(1)|P32854(1)|P33328(1)|Q04338(1) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0006895(Golgi to endosome transport)|GO:0006886(intracellular protein transport)|GO:0031201(SNARE complex)|GO:0031303(integral component of endosome membrane)|GO:0030173(integral component of Golgi membrane)|GO:0048210(Golgi vesicle fusion to target membrane) pubmed:24119662(see-also)|complex portal:CPX-5461(complex-primary)|pubmed:12453154(see-also)|pubmed:16912714(see-also)|pubmed:20521906(see-also) SNARE complex required for transport from the Golgi to endosomes. Mediates membrane fusion through the spontaneous assembly of four complementary SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) motifs. SNAREs bind to each other in-trans, that is, with SNAREs anchored in each apposed tethered membrane. The assembly process leads to a tight connection between the linked membranes and initiates membrane fusion. When interacting sets of SNAREs are combined, the SNARE motifs spontaneously associate to form elongated coiled coils of four intertwined, parallel alpha-helices (a SNAREpin), with each helix being provided by a different SNARE motif. The centre of the bundle contains 16 stacked layers of interacting side chains. These layers are largely hydrophobic, except for a central 0 layer that contains three highly conserved glutamine (Q) residues and one highly conserved arginine (R) residue. SNARE motifs are classified into Qa-, Qb-, Qc- and R-SNAREs and the hetero-oligomeric SNARE complexes that drive membrane fusion require that each parallel four-helix bundles is invariant and contains one each of the Qa-, Qb-, Qc- and R-SNAREs. Heterotetramer - - - - - psi-mi:"MI:0486"(UniProt) P31377(1)|P32854(1)|P33328(1)|Q04338(1) +CPX-5462 Endosomal SNARE complex PEP12-VTI1-TLG1-SNC2 - 559292 P32854(1)|P33328(1)|Q03322(1)|Q04338(1) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0006886(intracellular protein transport)|GO:0031201(SNARE complex)|GO:0031303(integral component of endosome membrane)|GO:0006895(Golgi to endosome transport)|GO:0030173(integral component of Golgi membrane)|GO:0048210(Golgi vesicle fusion to target membrane) pubmed:12453154(see-also)|pubmed:16912714(see-also)|pubmed:24119662(see-also)|complex portal:CPX-5462(complex-primary)|pubmed:20521906(see-also) SNARE complex required for transport from the Golgi to endosomes. Mediates membrane fusion through the spontaneous assembly of four complementary SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) motifs. SNAREs bind to each other in-trans, that is, with SNAREs anchored in each apposed tethered membrane. The assembly process leads to a tight connection between the linked membranes and initiates membrane fusion. When interacting sets of SNAREs are combined, the SNARE motifs spontaneously associate to form elongated coiled coils of four intertwined, parallel alpha-helices (a SNAREpin), with each helix being provided by a different SNARE motif. The centre of the bundle contains 16 stacked layers of interacting side chains. These layers are largely hydrophobic, except for a central 0 layer that contains three highly conserved glutamine (Q) residues and one highly conserved arginine (R) residue. SNARE motifs are classified into Qa-, Qb-, Qc- and R-SNAREs and the hetero-oligomeric SNARE complexes that drive membrane fusion require that each parallel four-helix bundles is invariant and contains one each of the Qa-, Qb-, Qc- and R-SNAREs. Heterotetramer - - - - - psi-mi:"MI:0486"(UniProt) P32854(1)|P33328(1)|Q03322(1)|Q04338(1) +CPX-1365 Vesicular SNARE complex SSO1-SEC9-SNC1 Soluble N-ethylmaleimide-sensitive factor (NSF) attachment receptor complex 559292 P31109(1)|P32867(1)|P40357(1) ECO:0000353(physical interaction evidence used in manual assertion) wwpdb:3B5N GO:0048210(Golgi vesicle fusion to target membrane)|GO:0006893(Golgi to plasma membrane transport)|GO:0030173(integral component of Golgi membrane)|GO:0016021(integral component of membrane)|GO:0005887(integral component of plasma membrane)|GO:0006886(intracellular protein transport)|GO:0006906(vesicle fusion)|GO:0031201(SNARE complex)|GO:0099500(vesicle fusion to plasma membrane) pubmed:28112172(see-also)|pubmed:20521906(see-also)|pubmed:17090679(see-also)|complex portal:CPX-1365(complex-primary)|intact:EBI-16519146(secondary-ac)|pubmed:24119662(see-also)|pubmed:16912714(see-also)|pubmed:19502581(see-also)|pubmed:11001046(see-also) An exocytic SNARE complex required for the fusion of post-Golgi secretory vesicles with the plasma membrane and is active primarily in vegetative cells. Mediates membrane fusion through the spontaneous assembly of four complementary SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) motifs. SNAREs bind to each other in-trans, that is, with SNAREs anchored in each apposed tethered membrane. The assembly process leads to a tight connection between the linked membranes and initiates membrane fusion. When interacting sets of SNAREs are combined, the SNARE motifs spontaneously associate to form elongated coiled coils of four intertwined, parallel alpha-helices (a SNAREpin), with each helix being provided by a different SNARE motif. The centre of the bundle contains 16 stacked layers of interacting side chains. These layers are largely hydrophobic, except for a central 0 layer that contains three highly conserved glutamine (Q) residues and one highly conserved arginine (R) residue. SNARE motifs are classified into Qa-, Qb-, Qc- and R-SNAREs and the hetero-oligomeric SNARE complexes that drive membrane fusion require that each parallel four-helix bundle is invariant and contains one each of the Qa-, Qb-, Qc- and R-SNAREs. SEC9 provides both Qb and Qc SNAREpin from its N- and C-terminal SNARE domain respectively. SSO1 contains an autoinhibitory domain that can prevent premature binary SSO1-SEC9 complex assembly. Heterotrimer - - - - - psi-mi:"MI:0486"(UniProt) P31109(1)|P32867(1)|P40357(1) +CPX-5463 Vesicular SNARE complex SSO1-SEC9-SNC2 Soluble N-ethylmaleimide-sensitive factor (NSF) attachment receptor complex 559292 P32867(1)|P33328(1)|P40357(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-16227092 GO:0016021(integral component of membrane)|GO:0099500(vesicle fusion to plasma membrane)|GO:0006893(Golgi to plasma membrane transport)|GO:0030173(integral component of Golgi membrane)|GO:0048210(Golgi vesicle fusion to target membrane)|GO:0005887(integral component of plasma membrane)|GO:0006886(intracellular protein transport)|GO:0006906(vesicle fusion)|GO:0031201(SNARE complex) pubmed:28112172(see-also)|pubmed:16912714(see-also)|pubmed:20521906(see-also)|complex portal:CPX-5463(complex-primary)|pubmed:24119662(see-also)|pubmed:19502581(see-also)|pubmed:11001046(see-also)|pubmed:17090679(see-also) An exocytic SNARE complex required for the fusion of post-Golgi secretory vesicles with the plasma membrane and is active primarily in vegetative cells. Mediates membrane fusion through the spontaneous assembly of four complementary SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) motifs. SNAREs bind to each other in-trans, that is, with SNAREs anchored in each apposed tethered membrane. The assembly process leads to a tight connection between the linked membranes and initiates membrane fusion. When interacting sets of SNAREs are combined, the SNARE motifs spontaneously associate to form elongated coiled coils of four intertwined, parallel alpha-helices (a SNAREpin), with each helix being provided by a different SNARE motif. The centre of the bundle contains 16 stacked layers of interacting side chains. These layers are largely hydrophobic, except for a central 0 layer that contains three highly conserved glutamine (Q) residues and one highly conserved arginine (R) residue. SNARE motifs are classified into Qa-, Qb-, Qc- and R-SNAREs and the hetero-oligomeric SNARE complexes that drive membrane fusion require that each parallel four-helix bundles is invariant and contains one each of the Qa-, Qb-, Qc- and R-SNAREs. SEC9 provides both Qb and Qc SNAREpin from its N- and C-terminal SNARE domain respectively. SSO1 contains an autoinhibitory domain that can prevent premature binary SSO1-SEC9 complex assembly. Heterotrimer - - - - - psi-mi:"MI:0486"(UniProt) P32867(1)|P33328(1)|P40357(1) +CPX-5464 Vesicular SNARE complex SSO1-SPO20-SNC1 Soluble N-ethylmaleimide-sensitive factor (NSF) attachment receptor complex 559292 P31109(0)|P32867(0)|Q04359(0) ECO:0005546(biological system reconstruction evidence based on paralogy evidence used in manual assertion) - GO:0031321(ascospore-type prospore assembly)|GO:0043934(sporulation)|GO:0030173(integral component of Golgi membrane)|GO:0005628(prospore membrane)|GO:0016021(integral component of membrane)|GO:0048210(Golgi vesicle fusion to target membrane)|GO:0006886(intracellular protein transport)|GO:0006906(vesicle fusion)|GO:0031201(SNARE complex) pubmed:10924463(see-also)|pubmed:11839791(see-also)|pubmed:16912714(see-also)|pubmed:24119662(see-also)|pubmed:20521906(see-also)|complex portal:CPX-1365(inferred-from)|complex portal:CPX-5464(complex-primary) SNARE complex required for the fusion of post-Golgi secretory vesicles with the pre-spore membrane. Mediates membrane fusion through the spontaneous assembly of four complementary SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) motifs. SNAREs bind to each other in-trans, that is, with SNAREs anchored in each apposed tethered membrane. The assembly process leads to a tight connection between the linked membranes and initiates membrane fusion. SPO20 induction is sporolation-specific. When interacting sets of SNAREs are combined, the SNARE motifs spontaneously associate to form elongated coiled coils of four intertwined, parallel alpha-helices (a SNAREpin), with each helix being provided by a different SNARE motif. The centre of the bundle contains 16 stacked layers of interacting side chains. These layers are largely hydrophobic, except for a central 0 layer that contains three highly conserved glutamine (Q) residues and one highly conserved arginine (R) residue. SNARE motifs are classified into Qa-, Qb-, Qc- and R-SNAREs and the hetero-oligomeric SNARE complexes that drive membrane fusion require that each parallel four-helix bundles is invariant and contains one each of the Qa-, Qb-, Qc- and R-SNAREs. SEC9 provides both Qb and Qc SNAREpin from its N- and C-terminal SNARE domain respectively. - - - - - - psi-mi:"MI:0486"(UniProt) P31109(0)|P32867(0)|Q04359(0) +CPX-5465 Vesicular SNARE complex SSO2-SEC9-SNC2 Soluble N-ethylmaleimide-sensitive factor (NSF) attachment receptor complex 559292 P33328(1)|P39926(1)|P40357(1) ECO:0005546(biological system reconstruction evidence based on paralogy evidence used in manual assertion) - GO:0099500(vesicle fusion to plasma membrane)|GO:0048210(Golgi vesicle fusion to target membrane)|GO:0006893(Golgi to plasma membrane transport)|GO:0030173(integral component of Golgi membrane)|GO:0005887(integral component of plasma membrane)|GO:0006886(intracellular protein transport)|GO:0006906(vesicle fusion)|GO:0031201(SNARE complex)|GO:0016021(integral component of membrane) pubmed:17090679(see-also)|pubmed:28112172(see-also)|pubmed:20521906(see-also)|complex portal:CPX-5463(inferred-from)|complex portal:CPX-5465(complex-primary)|pubmed:16912714(see-also)|pubmed:24119662(see-also) An exocytic SNARE complex required for the fusion of post-Golgi secretory vesicles with the plasma membrane and is active primarily in vegetative cells. Mediates membrane fusion through the spontaneous assembly of four complementary SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) motifs. SNAREs bind to each other in-trans, that is, with SNAREs anchored in each apposed tethered membrane. The assembly process leads to a tight connection between the linked membranes and initiates membrane fusion. When interacting sets of SNAREs are combined, the SNARE motifs spontaneously associate to form elongated coiled coils of four intertwined, parallel alpha-helices (a SNAREpin), with each helix being provided by a different SNARE motif. The centre of the bundle contains 16 stacked layers of interacting side chains. These layers are largely hydrophobic, except for a central 0 layer that contains three highly conserved glutamine (Q) residues and one highly conserved arginine (R) residue. SNARE motifs are classified into Qa-, Qb-, Qc- and R-SNAREs and the hetero-oligomeric SNARE complexes that drive membrane fusion require that each parallel four-helix bundles is invariant and contains one each of the Qa-, Qb-, Qc- and R-SNAREs. SEC9 provides both Qb and Qc SNAREpin from its N- and C-terminal SNARE domain respectively. SSO1 contains an autoinhibitory domain that can prevent premature binary SSO1-SEC9 complex assembly. Heterotrimer - - - - - psi-mi:"MI:0486"(UniProt) P33328(1)|P39926(1)|P40357(1) +CPX-5466 Vesicular SNARE complex SSO1-SPO20-SNC2 Soluble N-ethylmaleimide-sensitive factor (NSF) attachment receptor complex 559292 P32867(0)|P33328(0)|Q04359(0) ECO:0005546(biological system reconstruction evidence based on paralogy evidence used in manual assertion) - GO:0043934(sporulation)|GO:0030173(integral component of Golgi membrane)|GO:0005628(prospore membrane)|GO:0016021(integral component of membrane)|GO:0048210(Golgi vesicle fusion to target membrane)|GO:0031321(ascospore-type prospore assembly)|GO:0006886(intracellular protein transport)|GO:0006906(vesicle fusion)|GO:0031201(SNARE complex) pubmed:16912714(see-also)|pubmed:24119662(see-also)|pubmed:11839791(see-also)|complex portal:CPX-5463(inferred-from)|pubmed:10924463(see-also)|pubmed:20521906(see-also)|complex portal:CPX-5466(complex-primary) SNARE complex required for the fusion of post-Golgi secretory vesicles with the pre-spore membrane. Mediates membrane fusion through the spontaneous assembly of four complementary SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) motifs. SNAREs bind to each other in-trans, that is, with SNAREs anchored in each apposed tethered membrane. The assembly process leads to a tight connection between the linked membranes and initiates membrane fusion. SPO20 induction is sporulation-specific. When interacting sets of SNAREs are combined, the SNARE motifs spontaneously associate to form elongated coiled coils of four intertwined, parallel alpha-helices (a SNAREpin), with each helix being provided by a different SNARE motif. The centre of the bundle contains 16 stacked layers of interacting side chains. These layers are largely hydrophobic, except for a central 0 layer that contains three highly conserved glutamine (Q) residues and one highly conserved arginine (R) residue. SNARE motifs are classified into Qa-, Qb-, Qc- and R-SNAREs and the hetero-oligomeric SNARE complexes that drive membrane fusion require that each parallel four-helix bundles is invariant and contains one each of the Qa-, Qb-, Qc- and R-SNAREs. SEC9 provides both Qb and Qc SNAREpin from its N- and C-terminal SNARE domain respectively. - - - - - - psi-mi:"MI:0486"(UniProt) P32867(0)|P33328(0)|Q04359(0) +CPX-1369 Vesicular SNARE complex SSO2-SEC9-SNC1 Soluble N-ethylmaleimide-sensitive factor (NSF) attachment receptor complex 559292 P31109(1)|P39926(1)|P40357(1) ECO:0005546(biological system reconstruction evidence based on paralogy evidence used in manual assertion) - GO:0006886(intracellular protein transport)|GO:0006906(vesicle fusion)|GO:0031201(SNARE complex)|GO:0005887(integral component of plasma membrane)|GO:0006893(Golgi to plasma membrane transport)|GO:0016021(integral component of membrane)|GO:0030173(integral component of Golgi membrane)|GO:0048210(Golgi vesicle fusion to target membrane)|GO:0099500(vesicle fusion to plasma membrane) complex portal:CPX-1365(inferred-from)|pubmed:20521906(see-also)|complex portal:CPX-1369(complex-primary)|intact:EBI-16519362(secondary-ac)|pubmed:17090679(see-also)|pubmed:19502581(see-also)|pubmed:16912714(see-also)|pubmed:24119662(see-also)|pubmed:28112172(see-also) An exocytic SNARE complex required for the fusion of post-Golgi secretory vesicles with the plasma membrane and is active primarily in vegetative cells. Mediates membrane fusion through the spontaneous assembly of four complementary SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) motifs. SNAREs bind to each other in-trans, that is, with SNAREs anchored in each apposed tethered membrane. The assembly process leads to a tight connection between the linked membranes and initiates membrane fusion. When interacting sets of SNAREs are combined, the SNARE motifs spontaneously associate to form elongated coiled coils of four intertwined, parallel alpha-helices (a SNAREpin), with each helix being provided by a different SNARE motif. The centre of the bundle contains 16 stacked layers of interacting side chains. These layers are largely hydrophobic, except for a central 0 layer that contains three highly conserved glutamine (Q) residues and one highly conserved arginine (R) residue. SNARE motifs are classified into Qa-, Qb-, Qc- and R-SNAREs and the hetero-oligomeric SNARE complexes that drive membrane fusion require that each parallel four-helix bundles is invariant and contains one each of the Qa-, Qb-, Qc- and R-SNAREs. SEC9 provides both Qb and Qc SNAREpin from its N- and C-terminal SNARE domain respectively. By homology to SSO1,SSO2 contains an autoinhibitory domain that can prevent premature binary SSO2-SEC9 complex assembly. Homotrimer - - - - - psi-mi:"MI:0486"(UniProt) P31109(1)|P39926(1)|P40357(1) +CPX-5521 Vacuolar SNARE complex SSO1-SEC9-NYV1 Soluble N-ethylmaleimide-sensitive factor (NSF) attachment receptor complex 559292 P32867(1)|P40357(1)|Q12255(1) ECO:0005546(biological system reconstruction evidence based on paralogy evidence used in manual assertion) - GO:0016021(integral component of membrane)|GO:0005887(integral component of plasma membrane)|GO:0006886(intracellular protein transport)|GO:0006906(vesicle fusion)|GO:0031201(SNARE complex)|GO:0099500(vesicle fusion to plasma membrane)|GO:0071627(integral component of fungal-type vacuolar membrane) pubmed:11001046(see-also)|pubmed:16855025(see-also)|pubmed:20521906(see-also)|pubmed:24119662(see-also)|complex portal:CPX-5521(complex-primary)|complex portal:CPX-1365(inferred-from)|pubmed:19502581(see-also)|pubmed:16912714(see-also) SNARE complex required for the fusion of vacuoles with the plasma membrane and is active primarily in vegetative cells. Mediates membrane fusion through the spontaneous assembly of four complementary SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) motifs. SNAREs bind to each other in-trans, that is, with SNAREs anchored in each apposed tethered membrane. The assembly process leads to a tight connection between the linked membranes and initiates membrane fusion. When interacting sets of SNAREs are combined, the SNARE motifs spontaneously associate to form elongated coiled coils of four intertwined, parallel alpha-helices (a SNAREpin), with each helix being provided by a different SNARE motif. The centre of the bundle contains 16 stacked layers of interacting side chains. These layers are largely hydrophobic, except for a central 0 layer that contains three highly conserved glutamine (Q) residues and one highly conserved arginine (R) residue. SNARE motifs are classified into Qa-, Qb-, Qc- and R-SNAREs and the hetero-oligomeric SNARE complexes that drive membrane fusion require that each parallel four-helix bundles is invariant and contains one each of the Qa-, Qb-, Qc- and R-SNAREs. SEC9 provides both Qb and Qc SNAREpin from its N- and C-terminal SNARE domain respectively. SSO1 contains an autoinhibitory domain that can prevent premature binary SSO1-SEC9 complex assembly. Heterotrimer - - - - - psi-mi:"MI:0486"(UniProt) P32867(1)|P40357(1)|Q12255(1) +CPX-1800 CCR4-NOT mRNA deadenylase complex - 559292 CHEBI:18420(0)|P06100(0)|P06102(0)|P25655(0)|P31384(0)|P34909(0)|P39008(0)|P53280(0)|P53829(0)|Q12514(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-2564777 GO:0030015(CCR4-NOT core complex)|GO:0000175(3'-5'-exoribonuclease activity)|GO:0000289(nuclear-transcribed mRNA poly(A) tail shortening)|GO:0032968(positive regulation of transcription elongation from RNA polymerase II promoter) emdb:EMD-1901(identity)|intenz:3.1.13.4(identity)|wwpdb:4B8A(subset)|wwpdb:4CV5(subset)|wwpdb:4B8C(subset)|wwpdb:4BY6(subset)|complex portal:CPX-1800(complex-primary)|pubmed:21406554(see-also)|wwpdb:5ajd(subset)|pubmed:15196896(see-also) Major cellular mRNA deadenylase complex, removing polyA tails that protect transcripts from degradation and promotes translation in the cytoplasm. The complex is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation, and general transcription regulation, potentially by promoting the resumption of elongation of arrested RNAPII when it encounters transcriptional blocks in vivo. L-shaped, with two arms of 180A and 190A and a central hinge domain. The shorter arm is thought to be mainly formed by the Not proteins, whereas the longer, thinner arm, contains CAF40 and CAF130. CAF1 binds to the middle part of NOT1 and brings CCR4 to the scaffold - - - - - - psi-mi:"MI:0469"(IntAct) P06100(0)|P06102(0)|P25655(0)|P31384(0)|P34909(0)|P39008(0)|P53280(0)|P53829(0)|Q12514(0) +CPX-1805 Dynactin - 559292 P33420(0)|P36224(0)|P38696(0)|Q04549(0)|Q07887(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-2565988 GO:0015629(actin cytoskeleton)|GO:0030048(actin filament-based movement)|GO:0000132(establishment of mitotic spindle orientation)|GO:0005869(dynactin complex) complex portal:CPX-1805(complex-primary)|pubmed:18245366(see-also) Required for intracellular transport by dynein by localizing cytoplasmic dynein to its proper intracellular cargo and modulating dynein motor activity. Dynactin increases the run length of single dynein motors, but does not alter the directionality of dynein movement. Required for the spindle translocation late in anaphase and is involved in a cell wall synthesis checkpoint. A 20S assembly of total mass about 1.2 MDa. Comprises a short rod of the ARP1 filament attached to ARP10 at its pointed-end and probably associated with the actin capping protein at its barbed-end. The rod is implicated in dynein cargo binding. A sidearm formed by NIP100 projects from the ARP1 filament and is implicated in motor binding. - - - - - - psi-mi:"MI:0469"(IntAct) P33420(0)|P36224(0)|P38696(0)|Q04549(0)|Q07887(0) +CPX-1806 Rad17-Mec3-Ddc1 checkpoint clamp complex Checkpoint clamp complex|Rad17-Mec3-Ddc1 complex|9-1-1 complex|Rad17/3/1 559292 P48581(1)|Q02574(1)|Q08949(1) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0005634(nucleus)|GO:0003684(damaged DNA binding)|GO:0000077(DNA damage checkpoint)|GO:0030896(checkpoint clamp complex) complex portal:CPX-1806(complex-primary)|pubmed:17495536(see-also) Enables the DNA repair pathways to restore the integrity of the DNA prior to DNA synthesis or separation of the replicated chromosomes. Associates with sites of DNA damage and modulates the MEC1 signaling pathway and the activation of RAD53 in response to DNA damage at phase G1. Loads onto DNA in an ATP-dependent manner through its interaction with the RAD24-RFC checkpoint clamp loader complex (CPX-1807). The comples is reported as showing no detectable exonuclease activity. The complex also physically regulates DNA polymerase zeta-dependent mutagenesis by controlling the access of polymerase zeta to damaged DNA. - - - - - - - psi-mi:"MI:0469"(IntAct) P48581(1)|Q02574(1)|Q08949(1) +CPX-1807 Rad17 RFC-like complex Rad24-RFC checkpoint clamp loader complex 559292 P32641(0)|P38251(0)|P38629(0)|P40339(0)|P40348(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0016887(ATPase activity)|GO:0005524(ATP binding)|GO:0003689(DNA clamp loader activity)|GO:0000077(DNA damage checkpoint)|GO:0005634(nucleus)|GO:0003690(double-stranded DNA binding)|GO:0031389(Rad17 RFC-like complex) complex portal:CPX-1807(complex-primary) ATP-dependent clamp loader complex for the Rad17-Mec3-Ddc1 checkpoint clamp complex (CPX-1806). During a clamp loading circle, the RFC:clamp complex binds to DNA and the recognition of the double-stranded/single-stranded junction stimulates ATP hydrolysis by RFC. The complex presumably provides bipartite ATP sites in which one subunit supplies a catalytic site for hydrolysis of ATP bound to the neighbouring subunit. - - - - - - - psi-mi:"MI:0469"(IntAct) P32641(0)|P38251(0)|P38629(0)|P40339(0)|P40348(0) +CPX-1808 GCN1-GCN20 complex - 559292 P33892(0)|P43535(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-2566818 GO:0043022(ribosome binding)|GO:0006448(regulation of translational el)|GO:0034198(cellular response to amino aci) complex portal:CPX-1808(complex-primary) Functions on translating ribosomes to promote binding of uncharged tRNA to the A-site or in the transfer of uncharged tRNA from the A-site to the histidyl-tRNA synthetase (HisRS)-like domain in GCN2 for kinase activation. It is thus required for activation of GCN2 and the consequent induction of GCN4 translation in amino acid-starved cells. - - - - - - - psi-mi:"MI:0469"(IntAct) P33892(0)|P43535(0) +CPX-1809 MER2-MEI4-REC114 meiotic recombination initiation complex - 559292 P21651(0)|P29467(0)|P32841(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0000794(condensed nuclear chromosome)|GO:0042138(meiotic DNA double-strand break formation)|GO:0005634(nucleus) complex portal:CPX-1809(complex-primary) Appears to act as a regulatory subunit for the Spo11 loading onto potential double strand break sites, as an essential part of the initiation of meiotic recombination. - - - - - - - psi-mi:"MI:0469"(IntAct) P21651(0)|P29467(0)|P32841(0) +CPX-1810 NuA3 histone acetyltransferase complex NuA3 complex 559292 CHEBI:29105(0)|P34218(0)|P35189(0)|P47128(0)|Q08465(0)|Q12311(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-2567061 GO:0016573(histone acetylation)|GO:0004402(histone acetyltransferase activity)|GO:1990467(NuA3a histone acetyltransferase complex)|GO:0006351(transcription, DNA-templated)|GO:0005634(nucleus) complex portal:CPX-1810(complex-primary)|intenz:2.3.1.48(identity) Acetylates Histone H3 on Lys-14 of the mature histone protein, resulting in transcription elongation. Histone H3 methylation leads to the recruitment of NuA3 to nucleosomes, via binding of the Yng1 subunit. - - - - - - - psi-mi:"MI:0469"(IntAct) P34218(0)|P35189(0)|P47128(0)|Q08465(0)|Q12311(0) +CPX-1811 Sir2-3-4 silent chromatin complex Sir2-3-4 complex|Sir2-Sir3-Sir4 complex|SIR holocomplex 559292 P06700(1)|P06701(1)|P11978(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-443615 GO:0004407(histone deacetylase activity)|GO:0005677(chromatin silencing complex)|GO:0006342(chromatin silencing)|GO:0031491(nucleosome binding) complex portal:CPX-1811(complex-primary)|rhea:RHEA:43636(identity)|intenz:2.3.1.286(identity) Required for transcriptional repression of the silent mating type loci, HML and HMR. Spreads from sites of nucleation by first deacetylating the H3 and H4 histone tails, and then binding stably to nucleosomes to silence promoters up to 3 kb from the telomeric repeat. Mol. wt.= 750kDa - - - - - - psi-mi:"MI:0469"(IntAct) P06700(1)|P06701(1)|P11978(1) +CPX-1812 1,3-beta-D-glucan synthase complex, FKS1-RHO1 variant - 559292 P06780(0)|P38631(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-2567543 GO:0006075((1->3)-beta-D-glucan biosynthetic process)|GO:0000148(1,3-beta-D-glucan synthase complex)|GO:0009272(fungal-type cell wall biogenesis)|GO:0003843(1,3-beta-D-glucan synthase activity)|GO:0030476(ascospore wall assembly)|GO:0016021(integral component of membrane) complex portal:CPX-1812(complex-primary)|rhea:RHEA:21476(identity)|pubmed:17158736(see-also)|pubmed:8602515(see-also)|intenz:2.4.1.34(identity) Synthesizes 1,3-beta-glucan, a major structural component of the yeast cell wall and of the yeast spore wall. FKS1 variant is responsible for cell wall and spore wall assembly. - - - - - - - psi-mi:"MI:0469"(IntAct) P06780(0)|P38631(0) +CPX-1813 1,3-beta-D-glucan synthase complex, FKS2-RHO1 variant - 559292 P06780(0)|P40989(0) ECO:0005546(biological system reconstruction evidence based on paralogy evidence used in manual assertion) - GO:0006075((1->3)-beta-D-glucan biosynthetic process)|GO:0000148(1,3-beta-D-glucan synthase complex)|GO:0030476(ascospore wall assembly)|GO:0003843(1,3-beta-D-glucan synthase activity)|GO:0016021(integral component of membrane) complex portal:CPX-1812(inferred-from)|complex portal:CPX-1813(complex-primary)|rhea:RHEA:21476(identity)|pubmed:17158736(see-also)|pubmed:8602515(see-also)|pubmed:7565718(see-also)|intenz:2.4.1.34(identity) Synthesizes 1,3-beta-glucan, a major structural component of the yeast cell wall and of the yeast spore wall. GSC2/FKS2 variant is active during sporulation. - - - - - - - psi-mi:"MI:0469"(IntAct) P06780(0)|P40989(0) +CPX-1814 R2TP co-chaperone complex - 559292 P25638(0)|P38768(0)|Q03940(0)|Q12464(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0050821(protein stabilization)|GO:0000492(box C/D snoRNP assembly)|GO:0097255(R2TP complex) complex portal:CPX-1814(complex-primary)|pubmed:21925213(see-also) Co-chaperone that plays a role in box C/D snoRNP assembly/maintenance, especially under stress conditions. Also involved in the proper accumulation of box H/ACA small nucleolar RNAs. Regulates the stability of phosphatidylinositol 3-kinase-related protein kinases (PIKKs) such as TEL1 (P38110) and MEC1 (P38111), which are required for checkpoint signaling. Newly synthesized PIKK interacts with TEL2, in the TEL2–TTI1–TTI2 complex (CPX-1422), assisted by HSP90 (P02829). Phosphorylated TEl2 then mediates the interaction between PIKK and R2TP complex to eventually lead to the proper assembly of PIKK. - - - - - - - psi-mi:"MI:0469"(IntAct) P25638(0)|P38768(0)|Q03940(0)|Q12464(0) +CPX-6127 TIM23 mitochondrial inner membrane pre-sequence translocase complex, sort variant Mitochondrial inner membrane translocase complex|Inner mitochondrial membrane presequence translocase|Import inner membrane translocase|TIM23 complex 559292 P32897(0)|P39515(0)|P53220(0)|Q02776(0)|Q02889(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0030150(protein import into mitochondrial matrix)|GO:0045039(protein insertion into mitochondrial inner membrane)|GO:0031305(integral component of mitochondrial inner membrane)|GO:0030943(mitochondrion targeting sequence binding)|GO:0005744(TIM23 mitochondrial import inner membrane translocase complex) pubmed:16107694(see-also)|pubmed:16911507(see-also)|pubmed:17263664(see-also)|pubmed:32074073(see-also)|complex portal:CPX-6127(complex-primary) Major pre-protein translocase in the inner membrane of mitochondria, mediates the translocation of N-terminal, positively charged pre-sequence-containing proteins. Proteins in which the charged sequence is followed by a hydrophobic sorting signal are laterally transferred and inserted into the inner membrane. The sorting signal stalls the precursor in the channel and their release into the lipid bilayer is thought to occur through a lateral gate of the translocase with MGR2 proposed to act as a gatekeeper, partitioning proteins depending on the hydrophobicity of their sorting signals. - - - - - - psi-mi:"MI:0486"(UniProt) P32897(0)|P39515(0)|P53220(0)|Q02776(0)|Q02889(0) +CPX-539 TIM23 mitochondrial inner membrane pre-sequence translocase complex, motor variant TIM23 complex|Mitochondrial inner membrane translocase complex|Inner mitochondrial membrane presequence translocase|Import inner membrane translocase|TIM23-PAM complex 559292 P0CS90(0)|P32897(0)|P36147(0)|P38523(0)|P39515(0)|P42949(0)|Q01852(0)|Q02776(0)|Q07914(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0031305(integral component of mitochondrial inner membrane)|GO:0030943(mitochondrion targeting sequence binding)|GO:0005744(TIM23 mitochondrial import inner membrane translocase complex)|GO:0006886(intracellular protein transport)|GO:0008320(protein transmembrane transporter activity)|GO:0016887(ATPase activity)|GO:0005524(ATP binding) wwpdb:2guz(subset)|pubmed:16107694(see-also)|pubmed:16911507(see-also)|pubmed:17263664(see-also)|pubmed:32074073(see-also)|complex portal:CPX-539(complex-primary)|intact:EBI-1205157(secondary-ac)|intact:EBI-22052830(secondary-ac) Major pre-protein translocase in the inner membrane of mitochondria, mediates the translocation of N-terminal, positively charged pre-sequence-containing proteins. TIM50 interacts with incoming pre-sequence-carrying pre-proteins as they reach the trans site of the TOM40 complex (CPX-474). Pre-proteins are directed by the intermembrane space-exposed domains of TIM50, and TIM23 to the protein-conducting channel of the TIM23 complex. The pre-sequence translocase-associated motor (PAM) drives the completion of pre-protein translocation into the matrix. In most cases, the pre-sequence is proteolytically removed by the mitochondrial-processing peptidase (CPX-1630). Translocation is energetically driven by the electrical membrane potential across the inner membrane where they interact with the ATP-bound state of SSC1 (HSP77/mtHSP70). Upon ATP hydrolysis, SSC1 tightly binds the incoming chain and is released from the TIM23 complex. Repeated SSC1-binding cycles drive complete translocation of the precursor protein. SSC1 is finally released upon exchange of the bound ADP for ATP, a reaction stimulated by MGE1 (GRPE). Membrane-bound PAM16-PAM18 (TIM14-TIM16) regulates the ATPase activity of SSC1. This interaction is stabilised by PAM17 which promotes the PAM16-PAM18 association with the presequence translocase. - - - - - - psi-mi:"MI:0486"(UniProt) P0CS90(0)|P32897(0)|P36147(0)|P38523(0)|P39515(0)|P42949(0)|Q01852(0)|Q02776(0)|Q07914(0) +CPX-1830 CCAAT-binding factor complex CBF|HAP complex II|Hap2p/Hap3p/Hap4p/Hap5p-DNA Complex 559292 P06774(1)|P13434(1)|P14064(1)|Q02516(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-2609152 GO:0016602(CCAAT-binding factor complex)|GO:1990837(sequence-specific double-stranded DNA binding)|GO:0003700(DNA-binding transcription factor activity)|GO:0006109(regulation of carbohydrate metabolic process)|GO:0006355(regulation of transcription, DNA-templated) complex portal:CPX-1830(complex-primary)|pubmed:16278450(see-also)|pubmed:31379791(see-also) Transcriptional activator that binds to the 5'-CCAAT-3' consensus elements within promoters required for yeast to grow on nonermentable carbon sources such as cytochrome genes, thus acting as a global regulator of respiration. The Hap2/Hap3/Hap5 trimer is sufficient for CCAAT-specific binding at target promoters. Hap4, is necessary for transcriptional activation and is subject to glucose repression. - Heterotetramer - - - - - psi-mi:"MI:0469"(IntAct) P06774(1)|P13434(1)|P14064(1)|Q02516(1) +CPX-1831 Eukaryotic translation initiation factor 3 core complex eIF-3 core complex 559292 P06103(1)|P32497(1)|P38249(1)|P40217(1)|Q04067(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-9981752 GO:0003743(translation initiation factor activity)|GO:0005852(eukaryotic translation initiation factor 3 complex)|GO:0006413(translational initiation) complex portal:CPX-1831(complex-primary) Orchestrates several crucial steps in the translation initiation pathway. eIF3, eIF2 (CPX-427), eIF5, and eIF1 bind to each other to form a multifactor complex (MFC) which then binds to the 40S ribosome to form the 43S preinitiation complex. Thus formed, 43S preinitiation complex binds to mRNA to form 48S PIC and scans the mRNA leader region for the start codon. In addition to the five core subunits, yeast eIF3 complex has a loosely associated subunit, namely, Hcr1 (eIF3j/Q05775). This protein promotes the binding of eIF3 to the ribosome and is involved in ribosomal biogenesis as well as proper selection of the AUG start site. Mol. weight = approximately 360kDa Heteropentamer - - - - - psi-mi:"MI:0469"(IntAct) P06103(1)|P32497(1)|P38249(1)|P40217(1)|Q04067(1) +CPX-1832 tRNA-intron endonuclease complex - 559292 P16658(1)|P39707(1)|Q02825(1)|Q04675(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-2610250 GO:0000214(tRNA-intron endonuclease complex)|GO:0000049(tRNA binding)|GO:0000213(tRNA-intron endonuclease activity)|GO:0000379(tRNA-type intron splice site recognition and cleavage)|GO:0005741(mitochondrial outer membrane) complex portal:CPX-1832(complex-primary)|pubmed:9200603(see-also)|pubmed:25971974(see-also)|intenz:4.6.1.16(identity) Catalyzes the first step of tRNA splicing, cleaving the splice sites of all the intron-containing pre-tRNAs, either in the nucleus or on the mitochondrial surface after their export out of the nucleus. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. - - - - - - - psi-mi:"MI:0469"(IntAct) P16658(1)|P39707(1)|Q02825(1)|Q04675(1) +CPX-1833 SEC61 translocon complex PCC|Protein translocation channel 559292 P32915(0)|P35179(0)|P52870(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-9352403 GO:0005784(Sec61 translocon complex)|GO:0006616(SRP-dependent cotranslational protein targeting to membrane, translocation)|GO:0005048(signal sequence binding) complex portal:CPX-1833(complex-primary) Cotranslational protein translocation channel (PCC) that also assembles with the Sec62-Sec63 complex (CPX-3056) to form the post-translational translocon complex (CPX-3055). Transports secretory across, and inserts integral membrane proteins into, the membrane of the endoplasmic reticulum. The ribosome with an emerging signal sequence is targeted to the membrane by the signal recognition particle (CPX-609) and its receptor. The Sec61 complex acts as a receptor for the ribosome via its cytosolic loops. The alignment of the ribosomal tunnel with a central pore of the PCC allows direct movement of the nascent chain from the ribosomal tunnel exit across or into the membrane. The SEC61 channel appears to be responsible for the transport of glycoproteins. Binds to the oligosaccharyl transferase complex variant 2 (CPX-1639) which selectively glycosylates nascent polypeptide chains in the endoplasmic reticulum. Three to four Sec61 heterotrimers assemble into an oligomeric ring with a central aeqeous pore. In cotranslational ER import, the pore diameter varies from 9-15 A in a ribosome-free resting state to 40-60 A in a functional state when associated with the ribosome. Heterotrimer - - - - - psi-mi:"MI:0469"(IntAct) P32915(0)|P35179(0)|P52870(0) +CPX-1834 SSH1 translocon complex - 559292 P35179(1)|P38353(1)|P52871(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-2614607 GO:0006614(SRP-dependent cotranslational protein targeting to membrane)|GO:0071261(Ssh1 translocon complex)|GO:0030176(integral component of endoplasmic reticulum membrane)|GO:0005048(signal sequence binding) complex portal:CPX-1834(complex-primary) Forms the protein-conducting channel (PCC) for secretory and membrane proteins which engages in the post- and cotranslational translocation of secretory proteins across and the insertion of integral membrane proteins into the membrane of the endoplasmic reticulum. The ribosome with an emerging signal sequence is targeted to the membrane by the signal recognition particle (SRP) and its receptor. The Ssh1 complex acts as a receptor for the ribosome via its cytosolic loops. The alignment of the ribosomal tunnel with a central pore of the PCC allows direct movement of the nascent chain from the ribosomal tunnel exit across or into the membrane. The SSH1 translocon complex does not appear to be required for the transport of glycoproteins (see SEC61 translocon complex, CPX-1833). Recognizes proteins bearing strongly hydrophobic signal sequences. Binds to the oligosaccharyl transferase complex variant 1 (CPX-1638) which selectively glycosylates nascent polypeptide chains in the endoplasmic reticulum. - - - - - - - psi-mi:"MI:0469"(IntAct) P35179(1)|P38353(1)|P52871(1) +CPX-1835 Signal peptidase complex SPC 559292 P15367(0)|P46965(0)|Q04969(0)|Q12133(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-2614852 GO:0005787(signal peptidase complex)|GO:0006465(signal peptide processing)|GO:0008233(peptidase activity) complex portal:CPX-1835(complex-primary)|intenz:3.4.21.89(identity) Catalyzes the cleavage of N-terminal signal sequences of proteins targeted to the endoplasmic reticulum. The complex cleaves the signal peptides of most secretory and many membrane proteins as soon as the lumenal domain of the translocating polypeptide is large enough to expose its cleavage site to the enzyme, during the translocation of the protein through the translocon pore into the endoplasmic reticulum. - - - - - - - psi-mi:"MI:0469"(IntAct) P15367(0)|P46965(0)|Q04969(0)|Q12133(0) +CPX-1836 RNA polymerase I core factor complex Core factor|CF 559292 P32786(0)|P40992(0)|Q04712(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0001181(RNA polymerase I general transcription initiation factor activity)|GO:0070860(RNA polymerase I core factor complex)|GO:0042790(nucleolar large rRNA transcription by RNA polymerase I)|GO:0001164(RNA polymerase I core promoter sequence-specific DNA binding)|GO:0005634(nucleus) complex portal:CPX-1836(complex-primary)|pubmed:25132180(see-also) Transcription preinitiation complex which binds tightly to the upstream element of the RNA Polymerase I (RNAP-I, CPX-1664) promoter of 35S rRNA genes. Initiation of transcription requires the assembly of the upstream activating factor (UAF, CPX-1101), the core factor (CF), the TATA binding protein SPT15, and RNAP-I with RRN3 on the upstream element and core promoter. Upon transcription initiation, UAF, RRN3 and CF dissociate from the promoter. - - - - - - - psi-mi:"MI:0469"(IntAct) P32786(0)|P40992(0)|Q04712(0) +CPX-1837 CUL3-HRT1/ELC1/ELA1 ubiquitin ligase complex Elc1/Ela1/Cul3/Hrt1 ubiquitin ligase complex|ELA1-ELC1 complex|Elc1/Ela1 complex 559292 P53202(0)|P53861(0)|Q03071(0)|Q08273(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0006511(ubiquitin-dependent protein catabolic process)|GO:0006289(nucleotide-excision repair)|GO:0031463(Cul3-RING ubiquitin ligase complex)|GO:0004842(ubiquitin-protein transferase activity) complex portal:CPX-1837(complex-primary) Ubiquitin ligase complex. Required for lysine 48-linked polyubiquitylation of Rpb1, the largest subunit of RNA polymerase II, which targets Pol II for proteasomal degradation, removing stalled RNA polymerase II from a DNA lesion site enabling the repair machinery to bind. - - - - - - - psi-mi:"MI:0469"(IntAct) P53202(0)|P53861(0)|Q03071(0)|Q08273(0) +CPX-1838 a-agglutinin - 559292 P32323(1)|P32781(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-2620155 GO:0000752(agglutination involved in conjugation with cellular fusion)|GO:0050839(cell adhesion molecule binding) complex portal:CPX-1838(complex-primary)|pubmed:1579109(see-also) Cell surface mannoproteins that mediate cell-cell adhesion of haploid cells during mating. The a- and alpha-agglutinins, expressed by MATa and MATalpha cells, respectively, interact directly with 1:1 stoichiometry. Exposure to the pheromone expressed by the opposite mating type induces agglutinin expression and thus facilitates the agglutination reaction. - Heterodimer - - - - - psi-mi:"MI:0469"(IntAct) P32323(1)|P32781(1) +CPX-1840 COG Golgi transport complex COG complex|Conserved oligomeric Golgi complex|Golgi transport complex 559292 P40094(0)|P53079(0)|P53195(0)|P53271(0)|P53951(0)|P53959(0)|Q04632(0)|Q06096(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-2626463 GO:0017119(Golgi transport complex)|GO:0000301(retrograde transport, vesicle recycling within Golgi)|GO:0090498(extrinsic component of Golgi membrane) complex portal:CPX-1840(complex-primary)|pubmed:16406524(see-also) Peripheral membrane oligomeric protein complex which acts as a retrograde vesicle tethering factor in intra-Golgi protein trafficking, bringing cargo vesicles in close proximity to their target compartment. May play a role in protein glycosylation by directly or indirectly effecting transport, retention, or retrieval to appropriate cisternae of resident Golgi glycosylation enzymes. M.W. = approx. 800 kDa. Composed of eight subunits that are located in two lobes; Lobe A contains COG1-4, and Lobe B is composed of COG5-8 with COG1 acting as a bridging subunit between the two COG lobes. - - - - - - psi-mi:"MI:0469"(IntAct) P40094(0)|P53079(0)|P53195(0)|P53271(0)|P53951(0)|P53959(0)|Q04632(0)|Q06096(0) +CPX-1846 Histone H2A phosphatase complex HTP-C 559292 P32345(0)|P38193(0)|P40164(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0030289(protein phosphatase 4 complex)|GO:0004721(phosphoprotein phosphatase activity)|GO:0004722(protein serine/threonine phosphatase activity)|GO:0051598(meiotic recombination checkpoint signaling) complex portal:CPX-1846(complex-primary)|rhea:RHEA:20629(identity)|intenz:3.1.3.16(identity) Dephosphorylates gammaH2AX, a required step in efficient recovery from the DNA damage checkpoint following a double-strand break repair. The phosphatase appears to target gammaH2AX after its displacement from DNA. - - - - - - - psi-mi:"MI:0469"(IntAct) P32345(0)|P38193(0)|P40164(0) +CPX-1848 ATG12-ATG5 complex APG12-APG5 complex 559292 P38316(1)|Q12380(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-2639430 GO:0019776(Atg8 ligase activity)|GO:0000045(autophagosome assembly)|GO:0006497(protein lipidation)|GO:0016236(macroautophagy)|GO:0005829(cytosol)|GO:1990234(transferase complex) complex portal:CPX-1848(complex-primary)|pubmed:20056399(see-also) Essential for autophagy during nutrient deprivation, a catabolic process that sequesters undesired cellular material into autophagosomes for delivery to lysosomes for degradation. Contributes to nutrition homeostasis and damage control in eukaryotic cells. Acts as an E3-like ligase. This activity is dependent on ATP and two enzymes, ATG7 (P38862) an E1-like activating enzyme and ATG10 (Q07879) an E2-like conjugating enzyme. Required for lipidation of ATG8 (P38182) (e.g. to phosphatidylethanolamine) and associates with the vesicle membranes once bound to ATG16 (CPX-1849). The ubiquitin-like molecule ATG12 is covalently conjugated to ATG5 via a glycyl-lysine isopeptide resulting from the sequential reactions of ATG7 and the E2-like enzyme ATG10. Heterodimer - - - - - psi-mi:"MI:0469"(IntAct) P38316(1)|Q12380(1) +CPX-1849 ATG12-ATG5-ATG16 complex APG12-APG5-APG16 complex|ATG12 conjugation system|ATG16L1 complex 559292 P38316(4)|Q03818(4)|Q12380(4) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-2639790 GO:0034274(Atg12-Atg5-Atg16 complex)|GO:0016236(macroautophagy)|GO:0034045(pre-autophagosomal structure membrane)|GO:0000045(autophagosome assembly)|GO:0006497(protein lipidation) complex portal:CPX-1849(complex-primary)|wwpdb:2dym(subset)|wwpdb:3w1s(identity)|wwpdb:2dyo(subset)|pubmed:20056399(see-also) Essential for autophagy during nutrient deprivation, a catabolic process that sequesters undesired cellular material into autophagosomes for delivery to lysosomes for degradation. Functions as an E3-like enzyme in the ATG8 conjugation system. The ATG12-ATG5-ATG16 complex targets the autophagic membrane via the ATG5-ATG16 complex moiety and then recruits an ATG3:ATG8 thioester intermediate via the interaction between ATG3 and ATG12. The ATG12-ATG5 (CPX-1848) conjugate facilitates the transfer reaction of ATG8 from ATG3 to phosphatidylethanolamine (PE) through a reorganization of the catalytic centre of the E2-like enzyme ATG3. The C-terminal glycine of ATG8 is then conjugated to the amine moiety of PE. The role of ATG16, which has no E3-like activity appears to be to target the ATG12-ATG5 conjugate to the autophagic membranes. ATG8-PE/ATG12-ATG5 complexes form homogeneous oligomers, comprising two to four subunits. ATG16 may then act to reorganize ATG8-PE/ATG12-ATG5 oligomers to form a continuous, flat protein layer with meshwork-like architecture on membranes. ATG12 is constitutively conjugated to ATG5, via a glycyl-lysine isopeptide. Formation of the complex is mediated by ATG16 homo-oligomerization. MW ~ 350kDa Dodecamer - - - - - psi-mi:"MI:0469"(IntAct) P38316(4)|Q03818(4)|Q12380(4) +CPX-1850 Anthranilate synthase complex InGPSase/ASase complex; 559292 P00899(1)|P00937(1) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0005950(anthranilate synthase complex)|GO:0004049(anthranilate synthase activity)|GO:0000162(tryptophan biosynthetic process)|GO:0006541(glutamine metabolic process) complex portal:CPX-1850(complex-primary)|pubmed:3881257(see-also)|intenz:4.1.3.27(identity) Catalyses the conversion of chorismic acid to anthranilic acid in the first step in the tryptophan branch of aromatic amino acid biosynthesis. Tryptophan-specific regulation of enzyme activity level occurs through feedback regulation by the end product of the pathway, regulated by a tryptophan regulatory element (62LLESAKTNNELDRYS76) within Trp2. Component I (Trp2) and Component II (Trp3) are required for glutamine-dependent ASase activity while component I can use ammonia as cosubstrate without need of complex formation. . The C-terminal half of Trp3 also has indole-3-glycerol phosphate synthase activity. Mol. Wt. = 130kDa Heterodimer - - - - - psi-mi:"MI:0469"(IntAct) P00899(1)|P00937(1) +CPX-1851 RPD3S histone deacetylase complex Rpd3/Sin3 complex|Rpd3-Sin3 complex|RPD3C(S)|Rpd3/Sin3 small histone deacetylase complex 559292 P22579(0)|P32561(0)|Q03010(0)|Q04779(0)|Q12432(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-1189378 GO:0006334(nucleosome assembly)|GO:0005634(nucleus)|GO:0032221(Rpd3S complex)|GO:0004407(histone deacetylase activity)|GO:0000122(negative regulation of transcription by RNA polymerase II)|GO:0003712(transcription coregulator activity) complex portal:CPX-1851(complex-primary)|rhea:RHEA:58196(identity)|intenz:3.5.1.98(identity) Histone deacetylase which functions by deacetylating chromatin, thereby limiting accessibility of the transcriptional machinery to the underlying DNA.. Rpd3S recognizes the SET2 methylated histones and deacetylates histones within transcribed sequences. This erases transcription elongation-associated histone acetylation and serves to repress the occurrence of spurious transcription initiation from cryptic start sites within open reading frames. May also act to promote nucleosome assembly like a histone chaperone and prevent RSC-dependent histone eviction from nucleosomes Mol. Wt. = 600kDa - - - - - - psi-mi:"MI:0469"(IntAct) P22579(0)|P32561(0)|Q03010(0)|Q04779(0)|Q12432(0) +CPX-1852 RPD3L histone deacetylase complex RPD3L complex|RPD3(L)|RPD3/SIN3 large histone deacetylase complex 559292 P22579(0)|P31385(0)|P32561(0)|P38255(0)|P38429(0)|P40505(0)|P50947(0)|Q03010(0)|Q07458(0)|Q08923(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0033698(Rpd3L complex)|GO:0004407(histone deacetylase activity)|GO:0006357(regulation of transcription by RNA polymerase II)|GO:0003712(transcription cofactor activity)|GO:0005634(nucleus)|GO:0006334(nucleosome assembly) complex portal:CPX-1852(complex-primary)|intenz:3.5.1.98(identity)|rhea:RHEA:58196(identity) Histone deacetylase recruited to promoters in association with specific transcription factors such as UME6 (P39001), ASH1 (P34233), IME1 (P21190), WHI5 (Q12416), and STB1 (P42845) where it acts as a promoter targeted regulator of transcription.. At the promoter region, RPD3 deacetylates specific lysine residues on histones H3 and H4 in a localized region spanning about two nucleosomes. May also act to promote nucleosome assembly like a histone chaperone and prevent RSC-dependent histone eviction from nucleosomes. During vegetative growth, the complex functions as a negative regulator for all genes, whereas upon nitrogen depletion it functions as a positive regulator early during meiosis. - - - - - - - psi-mi:"MI:0469"(IntAct) P22579(0)|P31385(0)|P32561(0)|P38255(0)|P38429(0)|P40505(0)|P50947(0)|Q03010(0)|Q07458(0)|Q08923(0) +CPX-1853 CKM complex SRB8/9/10/11 complex|CDK kinase module|SRB8-SRB11 complex 559292 P25648(0)|P38931(0)|P39073(0)|P47821(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-1792921 GO:0004693(cyclin-dependent protein serine/threonine kinase activity)|GO:0006468(protein phosphorylation)|GO:1990508(CKM complex)|GO:0036033(mediator complex binding) complex portal:CPX-1853(complex-primary)|rhea:RHEA:46608(identity)|intenz:2.7.11.23(identity)|rhea:RHEA:10216(identity)|pubmed:12200444(see-also)|intenz:2.7.11.22(identity) Cyclin-dependent kinase complex which reversibly associates with the Mediator complex (CPX-3226). The mediator complex lacking the CKM complex has a stimulatory effect on basal transcription. In contrast, the mediator complex containing the sub-complex represses basal transcription. This effect is independent of kinase activity but binding of the complex to the Mediator may interfere with RNAPII recruitment and repress transcription re-initiation. Mol. weight = 430 kDa. The complex is roughly 200 × 100 A in size, with two bent features protruding from a globular central density. - - - - - - psi-mi:"MI:0469"(IntAct) P25648(0)|P38931(0)|P39073(0)|P47821(0) +CPX-1854 Golgi SNARE complex SED5-BOS1-BET1-SEC22 - 559292 P22214(1)|P22804(1)|P25385(1)|Q01590(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-2643019 GO:0006906(vesicle fusion)|GO:0016021(integral component of membrane)|GO:0006888(endoplasmic reticulum to Golgi vesicle-mediated transport)|GO:0030176(integral component of endoplasmic reticulum membrane)|GO:1990702(integral component of Golgi cis cisterna membrane)|GO:0006886(intracellular protein transport)|GO:0048280(vesicle fusion with Golgi apparatus)|GO:0031201(SNARE complex) pubmed:16912714(see-also)|complex portal:CPX-1854(complex-primary)|pubmed:11959998(see-also)|pubmed:11001058(see-also)|pubmed:24119662(see-also) SNARE complex required for fusion of endoplasmic reticulum-derived vesicles at the cis-Golgi cisternae. Mediates membrane fusion through the spontaneous assembly of four complementary SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) motifs. SNAREs bind to each other in-trans, that is, with SNAREs anchored in each apposed tethered membrane. The assembly process leads to a tight connection between the linked membranes and initiates membrane fusion. When interacting sets of SNAREs are combined, the SNARE motifs spontaneously associate to form elongated coiled coils of four intertwined, parallel alpha-helices (a SNAREpin), with each helix being provided by a different SNARE motif. The centre of the bundle contains 16 stacked layers of interacting side chains. These layers are largely hydrophobic, except for a central 0 layer that contains three highly conserved glutamine (Q) residues and one highly conserved arginine (R) residue. SNARE motifs are classified into Qa-, Qb-, Qc- and R-SNAREs and the hetero-oligomeric SNARE complexes that drive membrane fusion require that each parallel four-helix bundles is invariant and contains one each of the Qa-, Qb-, Qc- and R-SNAREs. Heterotetramer - - - - - psi-mi:"MI:0469"(IntAct) P22214(1)|P22804(1)|P25385(1)|Q01590(1) +CPX-1855 Golgi SNARE complex SED5-GOS1-SFT1-YKT6 - 559292 P36015(1)|P38736(1)|P43682(1)|Q01590(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-2643033 GO:0006886(intracellular protein transport)|GO:0031201(SNARE complex)|GO:0006888(endoplasmic reticulum to Golgi vesicle-mediated transport)|GO:0006906(vesicle fusion)|GO:0016021(integral component of membrane)|GO:0030176(integral component of endoplasmic reticulum membrane)|GO:1990702(integral component of Golgi cis cisterna membrane)|GO:0048280(vesicle fusion with Golgi apparatus) complex portal:CPX-1855(complex-primary)|pubmed:16912714(see-also)|pubmed:12802061(see-also)|pubmed:11959998(see-also) SNARE complex required for fusion of endoplasmic reticulum-derived vesicles at the cis-Golgi cisternae. Mediates membrane fusion through the spontaneous assembly of four complementary SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) motifs. SNAREs bind to each other in-trans, that is, with SNAREs anchored in each apposed tethered membrane. The assembly process leads to a tight connection between the linked membranes and initiates membrane fusion. When interacting sets of SNAREs are combined, the SNARE motifs spontaneously associate to form elongated coiled coils of four intertwined, parallel alpha-helices (a SNAREpin), with each helix being provided by a different SNARE motif. The centre of the bundle contains 16 stacked layers of interacting side chains. These layers are largely hydrophobic, except for a central 0 layer that contains three highly conserved glutamine (Q) residues and one highly conserved arginine (R) residue. SNARE motifs are classified into Qa-, Qb-, Qc- and R-SNAREs and the hetero-oligomeric SNARE complexes that drive membrane fusion require that each parallel four-helix bundles is invariant and contains one each of the Qa-, Qb-, Qc- and R-SNAREs. Heterotetramer - - - - - psi-mi:"MI:0469"(IntAct) P36015(1)|P38736(1)|P43682(1)|Q01590(1) +CPX-1856 Serine/threonine-protein phosphatase PP2A variant 1 Serine/threonine-protein phosphatase 2A|Protein phosphatase 2A|Serine/threonine-protein phosphatase PP2A|Protein phosphatase PP2A 559292 CHEBI:29035(2)|P23594(1)|P31383(1)|Q00362(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-2271265 GO:0006470(protein dephosphorylation)|GO:0000159(protein phosphatase type 2A complex)|GO:0004722(protein serine/threonine phosphatase activity) rhea:RHEA:20629(identity)|rhea:RHEA:47004(identity)|complex portal:CPX-1856(complex-primary)|pubmed:10329624(see-also)|intenz:3.1.3.16(identity) A serine/threonine phosphatase, the activity of the catalytic subunit of which is highly regulated by members of a family of regulatory subunits, which determine the substrate specificity, (sub)cellular localization and catalytic activity of the PP2A holoenzymes. The catalytic subunits are subject to two types of post-translational modification, phosphorylation and methylation, which are also thought to be important regulatory devices. - - - - - - - psi-mi:"MI:0469"(IntAct) P23594(1)|P31383(1)|Q00362(1) +CPX-1857 Serine/threonine-protein phosphatase PP2A variant 2 Serine/threonine-protein phosphatase 2A|Protein phosphatase 2A|Serine/threonine-protein phosphatase PP2A|Protein phosphatase PP2A 559292 CHEBI:29035(2)|P23594(1)|P31383(1)|P38903(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-2643205 GO:0006470(protein dephosphorylation)|GO:0000159(protein phosphatase type 2A complex)|GO:0004722(protein serine/threonine phosphatase activity) rhea:RHEA:20629(identity)|pubmed:10329624(see-also)|rhea:RHEA:47004(identity)|complex portal:CPX-1857(complex-primary)|intenz:3.1.3.16(identity) A serine/threonine phosphatase, the activity of the catalytic subunit of which is highly regulated by members of a family of regulatory subunits, which determine the substrate specificity, (sub)cellular localization and catalytic activity of the PP2A holoenzymes. The catalytic subunits are subject to two types of post-translational modification, phosphorylation and methylation, which are also thought to be important regulatory devices. - - - - - - - psi-mi:"MI:0469"(IntAct) P23594(1)|P31383(1)|P38903(1) +CPX-1858 Serine/threonine-protein phosphatase PP2A variant 4 Serine/threonine-protein phosphatase 2A|Protein phosphatase 2A|Serine/threonine-protein phosphatase PP2A|Protein phosphatase PP2A 559292 CHEBI:29035(2)|P23595(1)|P31383(1)|P38903(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-807564 GO:0000159(protein phosphatase type 2A complex)|GO:0004722(protein serine/threonine phosphatase activity)|GO:0006470(protein dephosphorylation) rhea:RHEA:47004(identity)|rhea:RHEA:20629(identity)|complex portal:CPX-1858(complex-primary)|intenz:3.1.3.16(identity) A serine/threonine phosphatase, the activity of the catalytic subunit of which is highly regulated by members of a family of regulatory subunits, which determine the substrate specificity, (sub)cellular localization and catalytic activity of the PP2A holoenzymes. The catalytic subunits are subject to two types of post-translational modification, phosphorylation and methylation, which are also thought to be important regulatory devices. - - - - - - - psi-mi:"MI:0469"(IntAct) P23595(1)|P31383(1)|P38903(1) +CPX-1859 Serine/threonine-protein phosphatase PP2A variant 3 Serine/threonine-protein phosphatase 2A|Protein phosphatase 2A|Serine/threonine-protein phosphatase PP2A|Protein phosphatase PP2A 559292 CHEBI:29035(2)|P23595(1)|P31383(1)|Q00362(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-2271279 GO:0000159(protein phosphatase type 2A complex)|GO:0004722(protein serine/threonine phosphatase activity)|GO:0006470(protein dephosphorylation) complex portal:CPX-1859(complex-primary)|pubmed:10329624(see-also)|rhea:RHEA:20629(identity)|rhea:RHEA:47004(identity)|intenz:3.1.3.16(identity) A serine/threonine phosphatase, the activity of the catalytic subunit of which is highly regulated by members of a family of regulatory subunits, which determine the substrate specificity, (sub)cellular localization and catalytic activity of the PP2A holoenzymes. The catalytic subunits are subject to two types of post-translational modification, phosphorylation and methylation, which are also thought to be important regulatory devices. - - - - - - - psi-mi:"MI:0469"(IntAct) P23595(1)|P31383(1)|Q00362(1) +CPX-1861 GET4-GET5 transmembrane domain recognition complex TRC complex 559292 P31539(0)|P38276(0)|Q12118(0)|Q12125(1)|Q12285(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-16594741 GO:0072380(TRC complex)|GO:0006620(posttranslational protein targeting to endoplasmic reticulum membrane)|GO:0005829(cytosol)|GO:0140597(protein carrier activity) complex portal:CPX-1861(complex-primary)|pubmed:20850366(see-also)|wwpdb:3LKU(subset)|wwpdb:2wpv(subset) Escorts newly-synthesised tail-anchored proteins to GET3 (Q12154) for insertion into the endoplasmic reticulum membrane through the GET complex (CPX-956). The complex acts both as an active tethering device that brings GET3 into proximity with its substrates and enzymatically activates GET3 for transmembrane domain recognition. The complex may contain additional heat-shock domain proteins, and it is unclear how many of these are bound at any one time. - - - - - - - psi-mi:"MI:0469"(IntAct) P31539(0)|P38276(0)|Q12118(0)|Q12125(1)|Q12285(1) +CPX-1862 PeBoW complex NOP7 complex|Nop7 subcomplex|Nop7-Erb1-Ytm complex 559292 P53261(0)|Q04660(0)|Q12024(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-2650600 GO:0070545(PeBoW complex)|GO:0042273(ribosomal large subunit biogenesis)|GO:0006364(rRNA processing)|GO:0019843(rRNA binding) complex portal:CPX-1862(complex-primary)|pubmed:18448671(see-also)|pubmed:28115637(see-also) Role in coordinating ribosome biogenesis with cell cycle progression, necessary for the conversion of 27SA3 pre-rRNA to 27SBS pre-rRNA. Forms an extensive protein-protein and protein-RNA interaction network within early ribosome assembly intermediates in the nucleolus, thereby potentially serving as a hub for stabilizing or remodeling ribonucleoprotein neighborhoods during 60S subunit biogenesis - - - - - - - psi-mi:"MI:0469"(IntAct) P53261(0)|Q04660(0)|Q12024(0) +CPX-1863 TAP42-RRD1-SIT4 phosphatase complex Tap42-phosphatase complex 559292 CHEBI:29035(2)|P20604(1)|P40454(0)|Q04372(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0031929(TOR signaling)|GO:0000159(protein phosphatase type 2A complex)|GO:0004722(protein serine/threonine phosphatase activity) complex portal:CPX-1863(complex-primary)|intenz:3.1.3.16(identity) A serine/threonine protein phosphatase complex that plays a major role in TOR1/2 (P35169/P32600)-mediated signaling and gene expression. Rapamycin causes release of the phosphatase-RRD dimer from TAP42. The core enzyme of PP2A comprises a catalytic subunit, the C-subunit (PP2Ac), and a scaffolding protein, the A subunit. The substrate specificity of PP2A as well as its intracellular localization are defined by an array of distinct groups of B-type regulatory subunits that bind to the AC dimeric core to form a variety of heterotrimeric complexes. - - - - - - psi-mi:"MI:0469"(IntAct) P20604(1)|P40454(0)|Q04372(0) +CPX-1864 SIT4-SAP155 phosphatase complex SIT4 holoenzyme complex 559292 CHEBI:29035(2)|P20604(1)|P43612(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-2652507 GO:0008287(protein serine/threonine phosphatase complex)|GO:0004722(protein serine/threonine phosphatase activity)|GO:0000082(G1/S transition of mitotic cell cycle) complex portal:CPX-1864(complex-primary)|rhea:RHEA:20629(identity)|rhea:RHEA:47004(identity)|pubmed:19749176(see-also)|intenz:3.1.3.16(identity) Serine/threonine phosphatase complex which forms in response to nutrient deprivation, mediates G1 to S cell cycle progression and a number of signaling events controlled by the target of rapamycin TOR signaling cascade including growth, budding, NCR gene expression and GCN2-regulated translation. - - - - - - - psi-mi:"MI:0469"(IntAct) P20604(1)|P43612(0) +CPX-1865 SIT4-SAP185 phosphatase complex SIT4 holoenzyme complex 559292 CHEBI:29035(2)|P20604(1)|P40856(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-2662606 GO:0008287(protein serine/threonine phosphatase complex)|GO:0004722(protein serine/threonine phosphatase activity)|GO:0000082(G1/S transition of mitotic cell cycle)|GO:0000082(G1/S transition of mitotic cell cycle) complex portal:CPX-1865(complex-primary)|pubmed:19749176(see-also)|rhea:RHEA:20629(identity)|rhea:RHEA:47004(identity)|intenz:3.1.3.16(identity) Serine/threonine phosphatase complex which forms in response to nutrient deprivation, mediates G1 to S cell cycle progression and a number of signaling events controlled by the target of rapamycin TOR signaling cascade including growth, budding, NCR gene expression and Gcn2-regulated translation. - - - - - - - psi-mi:"MI:0469"(IntAct) P20604(1)|P40856(0) +CPX-1866 SIT4-SAP190 phosphatase complex SIT4 holoenzyme complex 559292 CHEBI:29035(2)|P20604(0)|P36123(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-2652516 GO:0004722(protein serine/threonine phosphatase activity)|GO:0000082(G1/S transition of mitotic cell cycle)|GO:0008287(protein serine/threonine phosphatase complex) complex portal:CPX-1866(complex-primary)|pubmed:19749176(see-also)|rhea:RHEA:20629(identity)|rhea:RHEA:47004(identity)|intenz:3.1.3.16(identity) Forms in response to nutrient deprivation, mediates G1 to S cell cycle progression and a number of signaling events controlled by the target of rapamycin TOR signaling cascade including growth, budding, NCR gene expression and Gcn2-regulated translation. - - - - - - - psi-mi:"MI:0469"(IntAct) P20604(0)|P36123(0) +CPX-1867 Nuclear mitotic cohesin complex Cohesin complex 559292 P32908(0)|P40541(0)|P47037(0)|Q12158(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-2653542 GO:0034990(nuclear mitotic cohesin complex)|GO:0003682(chromatin binding)|GO:0034087(establishment of mitotic sister chromatid cohesion) wwpdb:1w1w(subset)|wwpdb:4UX3(subset)|complex portal:CPX-1867(complex-primary)|pubmed:20436296(see-also) Required for sister chromatid cohesion during cell division, which enables cells to attach sister kinetochores to microtubules with opposing polarity (bi-orientation) and subsequently resists the tendency of these microtubules to pull chromatids toward opposite spindle poles. Before the commencement of replication, the cohesin complex (CPX-1408) is loaded onto DNA. The arms of the Smc1/3 molecules embrace the DNA, thereby forming a ring of approx. 40 nm diameter. The head domains of Smc1 and Smc3 are locked together by Scc1. Cohesion might be generated as the replication fork passes through the ring, entrapping both sister chromatids inside. At the metaphase to anaphase transition, Scc1 is cleaved by separase, thereby opening the lock of the Smc1/3 head domains. The ring opens and sister chromatids can be pulled to opposite spindle poles. Smc1 and Smc3 form a heterodimer with intramolecular coiled coils. Scc1 bridges the head domains of Smc1 and Smc3 and links them to Scc3. - - - - - - psi-mi:"MI:0469"(IntAct) P32908(0)|P40541(0)|P47037(0)|Q12158(0) +CPX-1868 SCC2-SCC4 cohesin loader complex scc2-scc4|Cohesin loading factor complex|SMC loading complex|Scc2/Scc4 complex 559292 P40090(1)|Q04002(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-2654867 GO:0034087(establishment of mitotic sister chromatid cohesion)|GO:1905309(positive regulation of cohesin loading)|GO:0000785(chromatin)|GO:0032116(SMC loading complex) wwpdb:4xdn(identity)|pubmed:25173104(see-also)|complex portal:CPX-1868(complex-primary)|pubmed:20436296(see-also) Required for the stable association of the cohesin complex (CPX-1867) with DNA and ensures its enrichment at the mitotic spindle of the centromere thus ensuring correct segregation of the sister chromatids into the daughter cells during cell replication. The RSC chromatin remodeling complex (CPX-1889/CPX-1888) recruits budding yeast SCC2/SCC4 to broad nucleosome-free regions and thhe SCC2/SCC4 complex cooperates with RSC to maintain nucleosome depletion at its binding sites. SCC4 determines cohesin localization through a conserved patch on its surface, targeting cohesin loading to a specific genomic locus. Heterodimer - - - - - psi-mi:"MI:0469"(IntAct) P40090(1)|Q04002(1) +CPX-1869 Nuclear condensin complex Condensin 559292 P38170(1)|P38989(1)|Q06156(1)|Q06680(1)|Q12267(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-2657900 GO:0000796(condensin complex)|GO:0003682(chromatin binding)|GO:0030261(chromosome condensation)|GO:0005524(ATP binding) wwpdb:4rsi(subset)|complex portal:CPX-1869(complex-primary)|pubmed:16756491(see-also) Essential for the structural organization of chromosomes during their segregation by the mitotic spindle. Condensin subunits localize along the axial core of pachytene chromosomes and probably introduce positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. Smc2 and Smc4, bent at their hinge regions, provide the V-shaped structural frame of condensin. The coiled-coil arms of the V end in twin-lobed globular ATPase heads, with which the additional subunits interact to perhaps form a protein ring. Heteropentamer - - - - - psi-mi:"MI:0469"(IntAct) P38170(1)|P38989(1)|Q06156(1)|Q06680(1)|Q12267(1) +CPX-608 ADA complex Ada2/Gcn5/Ada3 transcription activator complex|ADA histone acetyltransferase complex|ADA HAT complex 559292 P25554(0)|P25649(0)|P32494(0)|Q02336(0)|Q03330(0)|Q12433(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-1188686 GO:0140671(ADA complex)|GO:0004402(histone acetyltransferase activity)|GO:0016573(histone acetylation)|GO:0006357(regulation of transcription by RNA polymerase II)|GO:0005634(nucleus) pubmed:10839822(see-also)|pubmed:10490601(see-also)|complex portal:CPX-608(complex-primary)|intact:EBI-1250344(secondary-ac)|pubmed:21734642(see-also)|pubmed:28964624(see-also) Chromatin remodelling complex that primarily acetylates nucleosomal histones H3 and H2B. May not participate directly in transcription. ADA2 is thought to potentiate GCN5 catalytic activity and ADA3 to facilitate nucleosomal acetylation and an expanded lysine specificity. Shares the HAT module of ADA2-GCN5-NGG1-SGF29 with the related SAGA complex (CPX-656). - - - - - - - psi-mi:"MI:0469"(IntAct) P25554(0)|P25649(0)|P32494(0)|Q02336(0)|Q03330(0)|Q12433(0) +CPX-675 SLIK (SAGA-like) complex SALSA complex|SAGA variant complex|SAGA altered|Spt8 absent complex|SLIK|SLIK/SALSA complex 559292 P06844(0)|P25554(0)|P32494(0)|P32657(0)|P35177(0)|P38129(0)|P38811(0)|P50102(0)|P50875(0)|P53040(0)|P53165(0)|Q02336(0)|Q03067(0)|Q03330(0)|Q03761(0)|Q05027(0)|Q12030(0)|Q12060(0)|Q6WNK7(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-1189559 GO:0031493(nucleosomal histone binding)|GO:0031492(nucleosomal DNA binding)|GO:0046695(SLIK (SAGA-like) complex)|GO:0006357(regulation of transcription by RNA polymerase II)|GO:0016573(histone acetylation)|GO:0004402(histone acetyltransferase activity)|GO:0005634(nucleus) pubmed:33864814(see-also)|pubmed:15647753(see-also)|pubmed:12186975(see-also)|pubmed:17337012(see-also)|pubmed:15506919(see-also)|complex portal:CPX-675(complex-primary)|intact:EBI-1251264(secondary-ac)|rhea:RHEA:45948(identity) A transcriptional co-activator complex that accompanies Pol II during elongation, preferentially acetylates nucleosomal histones H3 and H2B and subsequently evicts nucleosomes from gene coding regions. Required for growth under stressful conditions to activate transcription of stress-responsive, Pol II-transcribed genes. Plays a role in the yeast retrograde response pathway that is important for gene expression changes during mitochondrial dysfunction. Organized into several functional submodules: a histone acetyltransferase (HAT) module consisting of GCN5, ADA2, NGG1/ADA3 and SGF29, histone deubiquitinase (DUB) subunit UBP8, a core architecture module consisting of HFI1, SPT7, SPT20, TAF5, TAF6, TAF9, TAF10 and TAF12, TBP-interaction subunit SPT3, substrate recognition subunit CHD1 and transcription factor-binding subunit TRA1. Closely related to SAGA complex (CPX-656) but contains a smaller form of Spt7 lacking the C-terminal SPT8 binding region and consequently lacks SAGA-typical TBP-binding protein Spt8. M.W. = 1.8 MDa. - - - - - - psi-mi:"MI:0469"(IntAct) P06844(0)|P25554(0)|P32494(0)|P32657(0)|P35177(0)|P38129(0)|P38811(0)|P50102(0)|P50875(0)|P53040(0)|P53165(0)|Q02336(0)|Q03067(0)|Q03330(0)|Q03761(0)|Q05027(0)|Q12030(0)|Q12060(0)|Q6WNK7(0) +CPX-392 Mitochondrial NIAUFX iron-sulfur cluster assembly complex NIAUFX Fe-S cluster assembly complex 559292 CHEBI:597326(2)|P25374(2)|P32463(2)|Q03020(2)|Q07540(2)|Q12184(2)|Q6Q560(2) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0016226(iron-sulfur cluster assembly)|GO:1990229(iron-sulfur cluster assembly complex)|GO:0005739(mitochondrion)|GO:0031071(cysteine desulfurase activity)|GO:0004322(ferroxidase activity) intenz:2.8.1.7(identity)|rhea:RHEA:43892(identity)|intenz:1.16.3.1(identity)|rhea:RHEA:11148(identity)|pubmed:24045011(see-also)|pubmed:26342079(see-also)|complex portal:CPX-392(complex-primary)|intact:EBI-11682464(secondary-ac)|pubmed:27540631(see-also)|pubmed:34199378(see-also) Required for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. NFS1 provides sulfur for Fe-S cluster assembly by cleaving this atom from the side chain of the substrate L-cysteine and storing it in the form of a persulfide. The ISU1 scaffold protein performs the transient assembly of the 2Fe-2S cluster using persulfide sulfur and Fe(II). Electrons are provided by a mitochondrial ferredoxin, YAH1. - Heterododecamer - - - - - psi-mi:"MI:0486"(UniProt) P25374(2)|P32463(2)|Q03020(2)|Q07540(2)|Q12184(2)|Q6Q560(2) +CPX-6864 BOL2-GRX3 iron-sulfur cluster assembly complex BOL2-GRX3 Fe-S cluster assembly complex|FRA2-GRX3 complex|Class II iron-sulfur assembly complex, BOL2-GRX3|Monothiol iron-sulfur assembly complex, BOL2-GRX3 559292 CHEBI:16856(1)|CHEBI:33737(1)|P53082(1)|Q03835(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-25647502 GO:0005737(cytoplasm)|GO:1990229(iron-sulfur cluster assembly complex)|GO:0016226(iron-sulfur cluster assembly)|GO:0055072(iron ion homeostasis)|GO:0005634(nucleus) pubmed:32910989(see-also)|pubmed:19715344(see-also)|complex portal:CPX-6864(complex-primary)|pubmed:27951647(see-also) Reversibly binds [Fe2-S2] clusters and appears to play a role in Fe-S cluster assembly and trafficking, and in transferring an intact [Fe2-S2] cluster to an apo acceptor protein. Active in the nucleo-cytoplasmic compartments. [2Fe-2S]-bridged heterocomplex with GRX3 providing two Cys ligands from the Cys-Gly-Phe-Ser (CGSF) active site and one glutathione molecule. BOL2 provides an invariant His which serves as a cluster ligand. Heterodimer - - - - - psi-mi:"MI:0486"(UniProt) P53082(1)|Q03835(1) +CPX-6865 BOL2-GRX4 iron-sulfur cluster assembly complex BOL2-GRX4 Fe-S cluster assembly complex|Monothiol iron-sulfur assembly complex, BOL2-GRX4|Class II iron-sulfur assembly complex, BOL2-GRX4 559292 CHEBI:16856(1)|CHEBI:33737(1)|P32642(1)|P53082(1) ECO:0005546(biological system reconstruction evidence based on paralogy evidence used in manual assertion) - GO:0005737(cytoplasm)|GO:1990229(iron-sulfur cluster assembly complex)|GO:0016226(iron-sulfur cluster assembly)|GO:0055072(iron ion homeostasis)|GO:0005634(nucleus) pubmed:32910989(see-also)|pubmed:19715344(see-also)|complex portal:CPX-6864(inferred-from)|complex portal:CPX-6865(complex-primary)|pubmed:27951647(see-also) Reversibly binds [2Fe-2S] clusters and appears to play a role in Fe-S cluster assembly and trafficking, and in transferring an intact [2Fe-2S] cluster to an apo acceptor protein. Active in the nucleo-cytoplasmic compartments. [2Fe-2S]-bridged heterocomplex with GRX4 providing two Cys ligands from the Cys-Gly-Phe-Ser (CGSF) active site and one glutathione molecule. BOL2 provides an invariant His which serves as a cluster ligand. Heterodimer - - - - - psi-mi:"MI:0486"(UniProt) P32642(1)|P53082(1) +CPX-1192 Vacuolar proton translocating ATPase complex, Golgi variant Vacuolar (H+)-ATPase complex|V-ATPase complex 559292 P0C5R9(1)|P16140(3)|P17255(3)|P22203(3)|P23968(1)|P25515(8)|P31412(1)|P32366(1)|P32610(1)|P32842(1)|P37296(1)|P39111(1)|P41807(1)|P48836(3)|P53262(1)|Q3E7B6(1) ECO:0000353(physical interaction evidence used in manual assertion) wwpdb:6o7w GO:0033176(proton-transporting V-type ATPase complex)|GO:1902600(proton transmembrane transport)|GO:0061795(Golgi lumen acidification)|GO:0046961(proton-transporting ATPase activity, rotational mechanism)|GO:0048388(endosomal lumen acidification)|GO:0030173(integral component of Golgi membrane)|GO:0031303(integral component of endosome membrane)|GO:0016021(integral component of membrane) wwpdb:5BW9(subset)|wwpdb:5D80(subset)|pubmed:16691471(see-also)|complex portal:CPX-1192(complex-primary)|intact:EBI-16210364(secondary-ac)|rhea:RHEA:57720(identity)|intenz:7.1.2.2(identity)|pubmed:27776355(see-also)|emdb:EMD-0648(identity)|wwpdb:6o7x(identity)|pubmed:30910982(see-also)|wwpdb:EMD-0647(identity)|wwpdb:6o7u(subset)|emdb:EMD-0645(subset)|wwpdb:6o7v(identity)|emdb:EMD-0646(identity)|pubmed:11948198(see-also)|pubmed:28247968(see-also)|pubmed:20529855(see-also)|wwpdb:6c6l(subset)|emdb:EMD-7348(subset) Translocates protons across a lipid bilayer via an ATP-driven rotary mechanism, thus acidifing the lumen of its resident organelle. As newly synthesized proteins traverse the Golgi apparatus they undergo post-translational modifications, including glycosylation, sulfation, and phosphorylation, and are targeted to their appropriate destination in a pH-dependent manner. Membrane-bound ion transporters/proton exchangers use the pH gradient to sequester metal ions to the vacuole and other cellular organelles. The combined action of the V-ATPase and membrane transporters plays a key role in maintaining cellular homoeostasis. The variant of the complex containing the STV1 subunit results in the retention of the V-ATPase complex on Golgi and endosomal membranes. The N-terminal domain of STV1 contains the W83KY sequence, which is necessary and sufficient for targeting the complex to the Golgi apparatus. When yeast cells are deprived of glucose, the V1 and VO regions separate and are no longer able to hydrolyze ATP and transport protons. The V-ATPase complex can be functionally separated into two subcomplexes: the V1 domain is a 600-650 kDa peripheral complex involved directly in ATP hydrolysis and the integral membrane V0 domain responsible for the translocation of protons across a membrane bilayer. The membrane-embedded V0 domain is assembled in the endoplasmic reticulum and is composed of components a, c, c', c'', d, e, f and VOA1 (VPH1 or STV1, VMA3, VMA11, VMA16, VMA6, VMA9, YPR170W-B, VOA1). The soluble V1 domain contains subunits A-H (VMA1, VMA2, VMA5, VMA8, VMA4, VMA7, VMA10, and VMA13) and consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. Sequential ATP hydrolysis by the AB subunits produces conformational changes in the A3B3 hexamer that induce rotation of the central stalk (DFd) and the c-ring (c8c'c'' VOA1). The c, c', and c'' subunits that form the c-ring have conserved glutamate residues on their outer alpha-helices that are required for proton translocation. For every three ATP hydrolysis events, there is one complete rotation of the central stalk and c-ring. Hetero-31-mer - - - - - psi-mi:"MI:0486"(UniProt) P0C5R9(1)|P16140(3)|P17255(3)|P22203(3)|P23968(1)|P25515(8)|P31412(1)|P32366(1)|P32610(1)|P32842(1)|P37296(1)|P39111(1)|P41807(1)|P48836(3)|P53262(1)|Q3E7B6(1) +CPX-1193 Vacuolar proton translocating ATPase complex, vacuole variant Vacuolar (H+)-ATPase complex|V-ATPase complex 559292 P0C5R9(1)|P16140(3)|P17255(3)|P22203(3)|P23968(1)|P25515(8)|P31412(1)|P32366(1)|P32563(1)|P32610(1)|P32842(1)|P39111(1)|P41807(1)|P48836(3)|P53262(1)|Q3E7B6(1) ECO:0005546(biological system reconstruction evidence based on paralogy evidence used in manual assertion) - GO:0071627(integral component of fungal-type vacuolar membrane)|GO:0016471(vacuolar proton-transporting V-type ATPase complex)|GO:1902600(proton transmembrane transport)|GO:0046961(proton-transporting ATPase activity, rotational mechanism)|GO:0007035(vacuolar acidification)|GO:0016021(integral component of membrane) wwpdb:5tj5(subset)|wwpdb:6o7t(subset)|emdb:EMD-0644(subset)|wwpdb:3j9t(subset)|wwpdb:3J9U(subset)|emdb:EMD-6284(subset)|emdb:EMD-6285(subset)|wwpdb:3J9V(subset)|emdb:EMD-6286(subset)|emdb:EMD-8409(subset)|wwpdb:5BW9(subset)|wwpdb:5D80(subset)|pubmed:16691471(see-also)|complex portal:CPX-1193(complex-primary)|intact:EBI-16220596(secondary-ac)|complex portal:CPX-1192(inferred-from)|pubmed:30910982(see-also)|pubmed:27776355(see-also)|intenz:7.1.2.2(identity)|rhea:RHEA:57720(identity)|pubmed:11948198(see-also)|pubmed:28247968(see-also)|pubmed:20529855(see-also)|wwpdb:6c6l(subset)|emdb:EMD-7348(subset) Translocates protons across a lipid bilayer via an ATP-driven rotary mechanism, thus acidifing the lumen of its resident organelle. Membrane-bound ion transporters/proton exchangers use the resulting pH gradient to sequester metal ions to the vacuole and other cellular organelles. The combined action of the V-ATPase and membrane transporters plays a key role in maintaining cellular homoeostasis. The variant of the complex containing the VPH1 subunit results in the retention of the V-ATPase complex on vacuole membranes. When yeast cells are deprived of glucose, the V1 and VO regions separate and are no longer able to hydrolyze ATP and transport protons. Reassembly is mediated by the RAVE complex (CPX-1627). The V-ATPase complex can be functionally separated into two subcomplexes: the V1 domain is a 600-650 kDa peripheral complex involved directly in ATP hydrolysis and the integral membrane V0 domain responsible for the translocation of protons across a membrane bilayer. The membrane-embedded V0 domain is assembled in the endoplasmic reticulum and is composed of components a, c, c', c'', d, e, f and VOA1 (VPH1 or STV1, VMA3, VMA11, VMA16, VMA6, VMA9, YPR170W-B, VOA1). The soluble V1 domain contains subunits A-H (VMA1, VMA2, VMA5, VMA8, VMA4, VMA7, VMA10, and VMA13) and consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. Sequential ATP hydrolysis by the AB subunits produces conformational changes in the A3B3 hexamer that induce rotation of the central stalk (DFd) and the c-ring (c8c'c'' VOA1). The c, c', and c'' subunits that form the c-ring have conserved glutamate residues on their outer alpha-helices that are required for proton translocation. For every three ATP hydrolysis events, there is one complete rotation of the central stalk and c-ring. Hetero-31-mer - - - - - psi-mi:"MI:0486"(UniProt) P0C5R9(1)|P16140(3)|P17255(3)|P22203(3)|P23968(1)|P25515(8)|P31412(1)|P32366(1)|P32563(1)|P32610(1)|P32842(1)|P39111(1)|P41807(1)|P48836(3)|P53262(1)|Q3E7B6(1) +CPX-6921 GRX4 iron-sulfur cluster assembly homodimer complex GRX4 Fe-S cluster assembly complex|Monothiol iron-sulfur assembly complex, GRX4|Class II iron-sulfur assembly complex, GRX4 559292 CHEBI:16856(2)|CHEBI:33737(1)|P32642(2) ECO:0005546(biological system reconstruction evidence based on paralogy evidence used in manual assertion) - GO:0005737(cytoplasm)|GO:1990229(iron-sulfur cluster assembly complex)|GO:0016226(iron-sulfur cluster assembly)|GO:0055072(iron ion homeostasis)|GO:0005634(nucleus) pubmed:32910989(see-also)|pubmed:19715344(see-also)|complex portal:CPX-6864(inferred-from)|pubmed:27951647(see-also)|complex portal:CPX-6921(complex-primary) Reversibly binds [2Fe-2S] clusters and appears to play a role in Fe-S cluster assembly and trafficking, and in transferring an intact [2Fe-2S] cluster to an apo acceptor protein. Active in the nucleo-cytoplasmic compartments. - Homodimer - - - - - psi-mi:"MI:0486"(UniProt) P32642(2) +CPX-6924 GRX3 iron-sulfur cluster assembly homodimer complex GRX3 Fe-S cluster assembly complex|Monothiol iron-sulfur assembly complex, GRX3|Class II iron-sulfur assembly complex, GRX3 559292 CHEBI:16856(2)|CHEBI:33737(1)|Q03835(2) ECO:0005546(biological system reconstruction evidence based on paralogy evidence used in manual assertion) - GO:0005737(cytoplasm)|GO:1990229(iron-sulfur cluster assembly complex)|GO:0016226(iron-sulfur cluster assembly)|GO:0055072(iron ion homeostasis)|GO:0005634(nucleus) pubmed:32910989(see-also)|pubmed:19715344(see-also)|complex portal:CPX-6864(inferred-from)|pubmed:27951647(see-also)|complex portal:CPX-6924(complex-primary) Reversibly binds [2Fe-2S] clusters and appears to play a role in Fe-S cluster assembly and trafficking, and in transferring an intact [2Fe-2S] cluster to an apo acceptor protein. Active in the nucleo-cytoplasmic compartments. - Homodimer - - - - - psi-mi:"MI:0486"(UniProt) Q03835(2) +CPX-6928 BOL1-GRX5 iron-sulfur cluster assembly complex BOL1-GRX5 Fe-S cluster assembly complex|Monothiol iron-sulfur assembly complex, BOL1-GRX5|Class II iron-sulfur assembly complex, BOL1-GRX5 559292 CHEBI:16856(1)|CHEBI:33737(1)|Q02784(1)|Q3E793(1) ECO:0005546(biological system reconstruction evidence based on paralogy evidence used in manual assertion) - GO:0005739(mitochondrion)|GO:1990229(iron-sulfur cluster assembly complex)|GO:0016226(iron-sulfur cluster assembly)|GO:0055072(iron ion homeostasis) pubmed:32910989(see-also)|pubmed:27532773(see-also)|complex portal:CPX-6864(inferred-from)|complex portal:CPX-6928(complex-primary) Reversibly binds [2Fe-2S] clusters and appears to play a role in Fe-S cluster assembly and trafficking, and in transferring an intact [2Fe-2S] cluster to an apo acceptor protein. Active in the nucleo-cytoplasmic compartments. [2Fe-2S]-bridged heterocomplex with GRX5 providing two Cys ligands from the Cys-Gly-Phe-Ser (CGSF) active site and one glutathione molecule. BOL1 provides an invariant His which serves as a cluster ligand. Heterodimer - - - - - psi-mi:"MI:0486"(UniProt) Q02784(1)|Q3E793(1) +CPX-6930 BOL3-GRX5 iron-sulfur cluster assembly complex BOL3-GRX5 Fe-S cluster assembly complex|Class II iron-sulfur assembly complex, BOL3-GRX5|Monothiol iron-sulfur assembly complex, BOL3-GRX5 559292 CHEBI:16856(1)|CHEBI:33737(1)|P39724(1)|Q02784(1) ECO:0005546(biological system reconstruction evidence based on paralogy evidence used in manual assertion) - GO:0005739(mitochondrion)|GO:1990229(iron-sulfur cluster assembly complex)|GO:0016226(iron-sulfur cluster assembly)|GO:0055072(iron ion homeostasis) pubmed:32910989(see-also)|pubmed:27532773(see-also)|complex portal:CPX-6864(inferred-from)|complex portal:CPX-6930(complex-primary) Reversibly binds [2Fe-2S] clusters and appears to play a role in Fe-S cluster assembly and trafficking, and in transferring an intact [2Fe-2S] cluster to an apo acceptor protein. Active in the nucleo-cytoplasmic compartments. [2Fe-2S]-bridged heterocomplex with GRX5 providing two Cys ligands from the Cys-Gly-Phe-Ser (CGSF) active site and one glutathione molecule. BOL3 provides an invariant His which serves as a cluster ligand. Heterodimer - - - - - psi-mi:"MI:0486"(UniProt) P39724(1)|Q02784(1) +CPX-6937 GRX7 iron-sulfur cluster assembly homodimer complex GRX7 Fe-S cluster assembly complex|Monothiol iron-sulfur assembly complex, GRX7|Class II iron-sulfur assembly complex, GRX7 559292 CHEBI:16856(2)|CHEBI:33737(1)|P38068(2) ECO:0005546(biological system reconstruction evidence based on paralogy evidence used in manual assertion) - GO:0005737(cytoplasm)|GO:1990229(iron-sulfur cluster assembly complex)|GO:0016226(iron-sulfur cluster assembly)|GO:0055072(iron ion homeostasis)|GO:0005634(nucleus) pubmed:32910989(see-also)|pubmed:19715344(see-also)|complex portal:CPX-6864(inferred-from)|complex portal:CPX-6937(complex-primary) Reversibly binds [2Fe-2S] clusters and appears to play a role in Fe-S cluster assembly and trafficking, and in transferring an intact [2Fe-2S] cluster to an apo acceptor protein. Active in the nucleo-cytoplasmic compartments. - Homodimer - - - - - psi-mi:"MI:0486"(UniProt) P38068(2) +CPX-6957 GRX5 iron-sulfur cluster assembly homodimer complex GRX5 Fe-S cluster assembly complex|Monothiol iron-sulfur assembly complex, GRX5|Class II iron-sulfur assembly complex, GRX5 559292 CHEBI:16856(2)|CHEBI:30408(1)|Q02784(2) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0097428(protein maturation by iron-sulfur cluster transfer)|GO:0005759(mitochondrial matrix)|GO:1990229(iron-sulfur cluster assembly complex)|GO:0016226(iron-sulfur cluster assembly)|GO:0055072(iron ion homeostasis) pubmed:32910989(see-also)|pubmed:24032439(see-also)|pubmed:11950925(see-also)|complex portal:CPX-6957(complex-primary) Reversibly binds Fe-S clusters and appears to play a role in Fe-S cluster assembly and trafficking. May also participate in the maturation of [4Fe-4S]2+ cluster-containing proteins in a glutathione-independent manner, possibly as a carrier protein to mediate the transfer of preassembled [4Fe-4S]2+ cluster to target proteins. Active in the mitchondria. - Homodimer - - - - - psi-mi:"MI:0486"(UniProt) Q02784(2) +CPX-1872 MRE11-RAD50-XRS2 meiotic recombination initiation complex Mre11 complex|MRX complex|MRE11/RAD50/XRS2 complex 559292 P12753(2)|P32829(1)|P33301(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-2794721 GO:0003690(double-stranded DNA binding)|GO:0004520(endodeoxyribonuclease activity)|GO:0005634(nucleus)|GO:0006302(double-strand break repair)|GO:0042138(meiotic DNA double-strand break formation)|GO:0030870(Mre11 complex)|GO:0016887(ATPase activity)|GO:0008310(single-stranded DNA 3'-5' exodeoxyribonuclease activity) complex portal:CPX-1872(complex-primary)|intenz:3.6(identity)|pubmed:17674145(see-also) Combined ATPase/endo/ 3-prime exonuclease complex which both senses and removes blocked DNA ends. The hydrolysis of ATP enables the complex to cleave DNA 15-25 base pairs away from diverse blocks through endonuclease activity. Plays a crucial role in mitotic cells for sensing and repairing double-stranded breaks (DSB) and is also required for meiotic recombination. Required for the formation of the DSB catalysed by the transesterase SPO11 (P23179) protein and subsequently removes covalently attached Spo11 from the 5' extremity of the breaks through its nuclease activity, to allow further break resection. The Mre11 complex also plays a role during meiosis in bridging DNA molecules together and in sensing SPO11 DSB and activating the DNA damage checkpoint. Clips double-stranded DNA in the vicinity of protein-blocked DNA ends. - - - - - - - psi-mi:"MI:0469"(IntAct) P12753(2)|P32829(1)|P33301(0) +CPX-1873 Nucleolar ribonuclease P complex RNase P|Ribonuclease P 559292 P28005(1)|P38208(1)|P38291(1)|P38336(1)|P38786(1)|P40571(1)|P41812(1)|P53218(1)|P53833(1)|URS0000413C32_559292(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-2839702 GO:0005655(nucleolar ribonuclease P complex)|GO:0003727(single-stranded RNA binding)|GO:0001682(tRNA 5'-leader removal)|GO:0004526(ribonuclease P activity) emdb:1929(identity)|pubmed:25205096(see-also)|pubmed:27187488(see-also)|complex portal:CPX-1873(complex-primary)|wwpdb:6agb(identity)|wwpdb:6AH3(identity)|emdb:EMD-9622(identity)|emdb:EMD-9616(identity) Responsible for the 5' endonucleolytic cleavage of precursor tRNAs (pre-tRNAs), catalyzing phosphodiester bond hydrolysis to remove approximately 12 leader nucleotides to yield mature tRNAs. The RNA subunit of the nucleolar RNase P is a catalytically active ribozyme that is capable of both recognizing and cleaving substrates efficiently and accurately. The protein component serves as an absolutely required cofactor. The Rpr1 RNA adopts an extended single-layered conformation that maintains a central helical core. The protein components form an interconnected hook-shaped architecture that tightly wraps around the RNA and stabilizes RNase P which then mediates the initial engagement with pre-tRNA . Heteroundecamer - - - - - psi-mi:"MI:0469"(IntAct) P28005(1)|P38208(1)|P38291(1)|P38336(1)|P38786(1)|P40571(1)|P41812(1)|P53218(1)|P53833(1) +CPX-1881 Phosphatidylinositol 3-kinase complex, class III, type I VPS34 PI3-kinase complex I|Vps34 Ptdins 3-kinase complex I 559292 P22219(0)|P22543(0)|P38270(0)|Q02948(0)|Q05789(2) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-11703142 GO:0016303(1-phosphatidylinositol-3-kinase activity)|GO:0034271(phosphatidylinositol 3-kinase complex, class III, type I)|GO:0006914(autophagy)|GO:0046854(phosphatidylinositol phosphorylation)|GO:0034045(phagophore assembly site membrane) complex portal:CPX-1881(complex-primary)|pubmed:24165940(see-also)|pubmed:18533003(see-also)|intenz:2.7.1.137(identity) Catalyzes phosphorylation of phosphatidyl inositol, one of the major phospholipids in the cell, specifically at the d-3 position of the inositol ring, to generate PtdIns(3)P (CHEBI:17283). The formation of PtdIns(3)P is crucial for membrane recruitment of ATG proteins and the early stage of autophagosome formation VPS34 and VPS15 intertwine in an anti-parallel fashion, with each of the three domains of VPS15 [kinase and helical (KINHEAT), and WD40] interacting with at least one domain of VPS34 [C2, helical and kinase (HELCAT)] - - - - - - psi-mi:"MI:0469"(IntAct) P22219(0)|P22543(0)|P38270(0)|Q02948(0)|Q05789(2) +CPX-1882 HAP1 transcriptional repressor complex, SSA1 variant HAP1-PSP71-MAS1-SRO9 complex|High-molecular-weight complex|HMC 559292 P0CE41(2)|P10591(3)|P25491(1)|P25567(5) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0045892(negative regulation of transcription, DNA-templated)|GO:0070482(response to oxygen levels)|GO:0005634(nucleus)|GO:0017053(transcription repressor complex) complex portal:CPX-1882(complex-primary) Represses the transcriptional activity of HAP1 in the absence of haem. When haem concentration increases, haem enhances the interaction of Hsp90 with HAP1 and binds to AP1, causing conformational changes in the multi-chaperone-HAP1 complex and leading to HAP1 activation. - Heteroundecamer - - - - - psi-mi:"MI:0469"(IntAct) P0CE41(2)|P10591(3)|P25491(1)|P25567(5) +CPX-1883 HAP1 transcriptional repressor complex, SSA2 variant Hap1-Ssa-Ydj1-Sro9 complex|High-molecular-weight complex|HMC 559292 P0CE41(2)|P10592(0)|P25491(1)|P25567(5) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0017053(transcription repressor complex)|GO:0045892(negative regulation of transcription, DNA-templated)|GO:0070482(response to oxygen levels)|GO:0005634(nucleus) complex portal:CPX-1883(complex-primary) Represses the transcriptional activity of HAP1 in the absence of haem. When haem concentration increases, haem enhances the interaction of Hsp90 with HAP1 and binds to HAP1, causing conformational changes in the multi-chaperone-HAP1 complex and leading to HAP1 activation. - - - - - - - psi-mi:"MI:0469"(IntAct) P0CE41(2)|P10592(0)|P25491(1)|P25567(5) +CPX-1884 HDA1 histone deacetylase complex Histone deacetylase complex 1 559292 P53973(2)|Q06623(1)|Q06629(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-2924247 GO:0004407(histone deacetylase activity)|GO:0016575(histone deacetylation)|GO:1990837(sequence-specific double-stranded DNA binding)|GO:0070823(HDA1 complex)|GO:0000122(negative regulation of transcription by RNA polymerase II) complex portal:CPX-1884(complex-primary)|pubmed:19573535(see-also)|pubmed:11287668(see-also)|intenz:3.5.1.98(identity)|rhea:RHEA:58196(identity) Class II histone deacetylase, recruited to specific promoter loci through sequence-specific DNA-binding proteins, for example the TUP1 repressor (P16649), and subsequently precisely modifies adjacent nucleosomes at the lysine residues of histones H2B and H3 to repress transcription. Also deacetylates the N-terminal tails of the histones via a nonspecific DNA-binding mechanism. Expected molecular wt. = 312.5 kDa,measured molecular wt. = 299.2 kDa. HDA1 binds to specific promoter sites, while HDA2-HDA3 binds to non-specific DNA sites and also act as anchors to position HDA1 in the proximity of the H2B and H3 histone tails. Heterotetramer - - - - - psi-mi:"MI:0469"(IntAct) P53973(2)|Q06623(1)|Q06629(1) +CPX-1885 NineTeen complex PRP19-associated complex|Nineteen complex|NTC 559292 P21374(0)|P32523(0)|P38302(0)|P53277(0)|Q03654(0)|Q04048(0)|Q06091(0)|Q12309(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-2924708 GO:0000974(Prp19 complex)|GO:0000398(mRNA splicing, via spliceosome) complex portal:CPX-1885(complex-primary) Required for spliceosome activation, associates with the spliceosome after the release of U1 and U4 to stabilize the association of U5 and U6 with the spliceosome. The NTC plays an important role in promoting or stabilizing high-specificity interactions between U6 and the 5' splice site and between U5 and the exon sequence at the splice junctions after U1 and U4 have dissociated - - - - - - - psi-mi:"MI:0469"(IntAct) P21374(0)|P32523(0)|P38302(0)|P53277(0)|Q03654(0)|Q04048(0)|Q06091(0)|Q12309(0) +CPX-1886 Post-mRNA release spliceosomal complex NTR complex|NTC-related complex 559292 P36118(0)|P53131(0)|Q06411(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0000349(generation of catalytic spliceosome for first transesterification step)|GO:0000390(spliceosomal complex disassembly)|GO:0071008(U2-type post-mRNA release spliceosomal complex)|GO:0004004(ATP-dependent RNA helicase activity) complex portal:CPX-1886(complex-primary)|intact:EBI-2925080(identity) Catalyzes disassembly of the spliceosome in an ATP-dependent manner, separating U2, U5, U6, NTC (NineTeen Complex, CPX-1885), and lariat-intron. - - - - - - - psi-mi:"MI:0469"(IntAct) P36118(0)|P53131(0)|Q06411(0) +CPX-1888 RSC chromatin remodelling complex, variant RSC2 RSC complex, RSC2 form|chromatin structure remodeling complex|remodel the structure of chromatin complex 559292 P25632(0)|P32597(0)|P32832(0)|P38210(0)|P38781(0)|P43609(0)|P53330(0)|Q02206(0)|Q03124(0)|Q05123(0)|Q06168(0)|Q06488(0)|Q06639(0)|Q07979(0)|Q12406(0)|Q9URQ5(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0140658(ATPase-dependent chromatin remodeler activity)|GO:0016586(RSC-type complex)|GO:0006338(chromatin remodeling)|GO:0003682(chromatin binding)|GO:0006303(double-strand break repair via nonhomologous end joining) complex portal:CPX-1888(complex-primary)|pubmed:31672915(see-also)|pubmed:31886770(see-also)|wwpdb:6k15(subset)|emdb:EMD-9905(subset)|intenz:3.6.4.12(identity)|rhea:RHEA:13065(identity) Member of the SWI/SNF family of ATP-dependent chromatin remodelers with a role in contributing to the integrity of centromeric DNA. The RSC complex is generally recruited to RNA polymerase III promoters and is specifically recruited to RNA polymerase II promoters by transcriptional activators and repressors where it is responsible for the transfer of a histone octamer from a nucleosome core particle to naked DNA. The reaction requires ATP and involves an activated RSC-nucleosome intermediate. The remodeling reaction also involves DNA translocation, DNA twist and conformational change. As a reconfigurer of centromeric and flanking nucleosomes, the RSC complex is required both for proper kinetochore function in chromosome segregation and, via a PKC1-dependent signaling pathway, for organization of the cellular cytoskeleton. It is also involved in non-homologous end joining. - - - - - - - psi-mi:"MI:0469"(IntAct) P25632(0)|P32597(0)|P32832(0)|P38210(0)|P38781(0)|P43609(0)|P53330(0)|Q02206(0)|Q03124(0)|Q05123(0)|Q06168(0)|Q06488(0)|Q06639(0)|Q07979(0)|Q12406(0)|Q9URQ5(0) +CPX-1889 RSC chromatin remodelling complex, variant RSC1 RSC complex, RSC2 form|chromatin structure remodeling complex|remodel the structure of chromatin complex 559292 P25632(0)|P32597(0)|P32832(0)|P38210(0)|P38781(0)|P43609(0)|P53236(0)|P53330(0)|Q02206(0)|Q03124(0)|Q05123(0)|Q06168(0)|Q06639(0)|Q07979(0)|Q12406(0)|Q9URQ5(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0006338(chromatin remodeling)|GO:0016586(RSC-type complex)|GO:0003682(chromatin binding)|GO:0006303(double-strand break repair via nonhomologous end joining)|GO:0000785(chromatin)|GO:0140658(ATPase-dependent chromatin remodeler activity) complex portal:CPX-1889(complex-primary)|pubmed:12183366(see-also)|pubmed:31886770(see-also)|rhea:RHEA:13065(identity)|intenz:3.6.4.12(identity) Member of the SWI/SNF family of ATP-dependent chromatin remodelers with a role in contributing to the integrity of centromeric DNA. The RSC complex is generally recruited to RNA polymerase III promoters and is specifically recruited to RNA polymerase II promoters by transcriptional activators and repressors where it is responsible for the transfer of a histone octamer from a nucleosome core particle to naked DNA. The reaction requires ATP and involves an activated RSC-nucleosome intermediate. The remodeling reaction also involves DNA translocation, DNA twist and conformational change. As a reconfigurer of centromeric and flanking nucleosomes, the RSC complex is required both for proper kinetochore function in chromosome segregation and, via a PKC1-dependent signaling pathway, for organization of the cellular cytoskeleton. It is also involved in non-homologous end joining. - - - - - - - psi-mi:"MI:0469"(IntAct) P25632(0)|P32597(0)|P32832(0)|P38210(0)|P38781(0)|P43609(0)|P53236(0)|P53330(0)|Q02206(0)|Q03124(0)|Q05123(0)|Q06168(0)|Q06639(0)|Q07979(0)|Q12406(0)|Q9URQ5(0) +CPX-1890 Exocyst - 559292 P19658(0)|P22224(0)|P32844(0)|P32855(0)|P33332(0)|P38261(0)|P89102(0)|Q06245(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-800676 GO:0000145(exocyst)|GO:0005546(phosphatidylinositol-4,5-bisphosphate binding)|GO:0006904(vesicle docking involved in exocytosis) complex portal:CPX-1890(complex-primary)|pubmed:26240175(see-also) Recruited to sites of active exocytosis and membrane expansion, where it mediates the tethering of secretory vesicles to the plasma membrane in preparation for soluble N-ethylmaleimide-sensitive factor (NSF) attachment protein receptor (SNARE)-mediated membrane fusion. The exocyst is localized to the emerging bud tip, where it mediates exocytosis for the asymmetric expansion of daughter cell surfaces during polarized cell growth. During cytokinesis, the exocyst is localized to the mother–daughter cell junction to mediate abscission. The targeting of secretory vesicles to the plasma membrane involves direct interactions of the exocyst with PI(4,5)P2. In addition, a number of small GTP-binding proteins interact with components of the exocyst and regulate the assembly, localization, and function of this complex. Assembles by side-by-side packing of rod-shaped subunits composed of helical bundles. - - - - - - psi-mi:"MI:0469"(IntAct) P19658(0)|P22224(0)|P32844(0)|P32855(0)|P33332(0)|P38261(0)|P89102(0)|Q06245(0) +CPX-1891 RPB4-RPB7 subcomplex RPB4/7 complex 559292 P20433(1)|P34087(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-1041332 GO:0005665(RNA polymerase II, core complex)|GO:0000932(P-body)|GO:1990328(RPB4-RPB7 complex)|GO:0003727(single-stranded RNA binding)|GO:0003690(double-stranded DNA binding)|GO:0003899(DNA-directed RNA polymerase activity)|GO:0006352(DNA-templated transcription, initiation)|GO:0000956(nuclear-transcribed mRNA catabolic process)|GO:0006413(translational initiation) complex portal:CPX-1891(complex-primary)|wwpdb:1Y14(identity) Shuttles between the nucleus and cytoplasm and mediates both transcription and the two major cytoplasmic mRNA decay pathways. Interacts with components of the translation initiation factor 3 (eIF3), and is required for efficient translation initiation. Efficient translation in the cytoplasm depends on association of RPB4/7 with RNA polymerase II (Pol II) in the nucleus. - Heterodimer - - - - - psi-mi:"MI:0469"(IntAct) P20433(1)|P34087(1) +CPX-1893 MPP10 complex U3 small nucleolar RNA-associated Mpp10 complex|U3 small nucleolar RNA-associated protein complex 559292 P32899(0)|P47083(0)|P53941(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0030515(snoRNA binding)|GO:0034457(Mpp10 complex)|GO:0042134(rRNA primary transcript binding)|GO:0030490(maturation of SSU-rRNA) complex portal:CPX-1893(complex-primary)|pubmed:27354316(see-also)|pubmed:27980088(see-also) Required for early co-transcriptional events in ribosome biogenesis, acting as an RNA chaperone to initiate ribosome assembly. IMP3 protein directly associates with the first 70 nucleotides of the U3 snoRNA, with a stem-loop structure within the hinge region, and thereby directs the preassembled MPP10 complex to the U3 preprocessome. A sub-unit of the small subunit (SSU) processome, a 2.2 MDa ribonucleoprotein complex involved in the processing, assembly and maturation of nascent pre-ribosomal RNA to form the small ribosomal subunit. The SSU processome is a giant particle composed of numerous ribosome assembly factors, including the UTP-A (CPX-1409), UTP-B (CPX-1410), UTP-C (CPX-772/CPX-771/CPX-773) and MPP10 complexes, the U3 small nucleolar ribonucleoprotein (snoRNP) and many individual proteins. - - - - - - - psi-mi:"MI:0469"(IntAct) P32899(0)|P47083(0)|P53941(0) +CPX-1894 COP9 signalosome complex COP9/signalosome|CSN complex 559292 CHEBI:29105(0)|P40512(0)|P47130(0)|Q03981(0)|Q04368(0)|Q12348(0)|Q12468(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-816044 GO:0008180(COP9 signalosome)|GO:0000338(protein deneddylation)|GO:0005634(nucleus)|GO:0000754(adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion) complex portal:CPX-1894(complex-primary) Essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes. Plays a role in the regulation of the mating pheromone response. CSN4 and CSN6 appear to be required for stabilizing and converting CSN5 into its active state, via rearrangement within CSN5 to open the NEDD8 binding pocket. Full enzymatic activity in vitro requires the complete set of subunits. - - - - - - psi-mi:"MI:0469"(IntAct) P40512(0)|P47130(0)|Q03981(0)|Q04368(0)|Q12348(0)|Q12468(0) +CPX-1895 mRNA cleavage factor complex CFIA Cleavage factor IA|CF IA 559292 P25298(2)|P25299(2)|P39081(1)|Q08685(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-3401802 GO:0005849(mRNA cleavage factor complex)|GO:0003729(mRNA binding)|GO:0098787(mRNA cleavage involved in mRNA processing)|GO:0006378(mRNA polyadenylation) complex portal:CPX-1895(complex-primary)|wwpdb:2npi(subset)|wwpdb:2l9b(subset) Required for the posttranscriptional maturation of mRNA 3' ends. CFI binds signal sequences at the 3' end of yeast mRNA. and is required for correct positioning of a larger protein complex, CPF (CPX-1053), which contains the catalytic subunits executing mRNA cleavage and polyadenylation. CFI (CPX-1896) and CFII recognize the processing signals of the RNA and perform the endonucleolytic cleavage, whereas CFI, polyadenylation factor I (PFI), and the single-polypeptide PAP1 are required for the polyadenylation step. CFIA forms a stable sub-complex RNA14 and RNA15 form a stable dimer of heterodimers Heterohexamer - - - - - psi-mi:"MI:0469"(IntAct) P25298(2)|P25299(2)|P39081(1)|Q08685(1) +CPX-1896 mRNA cleavage factor complex CFI CF I 559292 P25298(2)|P25299(2)|P39081(1)|Q08685(1)|Q99383(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0005849(mRNA cleavage factor complex)|GO:0098789(pre-mRNA cleavage required for polyadenylation)|GO:0003729(mRNA binding)|GO:0006378(mRNA polyadenylation) complex portal:CPX-1896(complex-primary)|pubmed:11344258(see-also) Required for the posttranscriptional maturation of mRNA 3' ends. CFI binds signal sequences at the 3' end of yeast mRNA. and is required for correct positioning of a larger protein complex, CFI and CFII recognize the processing signals of the RNA and perform the endonucleolytic cleavage, whereas CFI, polyadenylation factor I (PFI), and the single-polypeptide PAP1 are required for the polyadenylation step. CFIA (CPX-1895) forms a stable sub-complex. RNA14 and RNA15 form a stable dimer of heterodimers - - - - - - psi-mi:"MI:0469"(IntAct) P25298(2)|P25299(2)|P39081(1)|Q08685(1)|Q99383(0) +CPX-1898 CBF3 complex centromere DNA-binding protein complex CBF3|CBF3A-CBF3B-CBF3C-SKP1 complex 559292 P32504(2)|P35203(1)|P40969(2)|P52286(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-21452579 GO:0051382(kinetochore assembly)|GO:0000776(kinetochore)|GO:0019237(centromeric DNA binding)|GO:0031518(CBF3 complex) complex portal:CPX-1898(complex-primary)|wwpdb:6F07(subset)|wwpdb:6gyu(identity)|emdb:EMD-0097(identity)|pubmed:30478265(see-also)|pubmed:14570580(see-also) Binds to the CDEIII DNA element, conserved between all yeast chromosomes, early in kinetochore assembly and acts as the the primary determinant of assembly. Binding of the CBF3 complex and presence of the unique N-terminal tails of the two CSE4 (P36012) molecules in the nucleosome could cooperate to induce a sharp bending of the centromeric DNA, thus creating a C-loop structure in which the CSE4 nucleosome is proximal to the plus end of the kinetochore. Alternatively, CSE4-nucleosomes are part of the highly phased array of nucleosomes on either side of the CEN-sequence, while CFB3 occupies CDEIII and additional Ndc10 molecules occupy the CDEII sites to form an extended binding platform. microtubule In the presence of cen3 DNA,a dimeric CBF3−cen3 complex in which two CBF3 complexes, bridged by a central CBF2 dimer, are bound to a single cen3 DNA duplex Heterohexamer - - - - - psi-mi:"MI:0469"(IntAct) P32504(2)|P35203(1)|P40969(2)|P52286(1) +CPX-1899 Spc105 complex - 559292 P53148(0)|Q04431(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-1543641 GO:0000776(kinetochore)|GO:0051382(kinetochore assembly) complex portal:CPX-1899(complex-primary)|pubmed:14565975(see-also)|pubmed:14570580(see-also) Located to the kinetochore, interacts with centromere proteins. - - - - - - - psi-mi:"MI:0469"(IntAct) P53148(0)|Q04431(0) +CPX-1900 Chromosomal passenger complex BIR1-IPL1-NBL1-SLI15 kinetochore-associated complex|CPC|Ipl1 kinase complex|Aurora kinase complex 559292 CHEBI:29105(0)|P38283(0)|P38991(0)|P47134(0)|Q3E7Y6(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-9513779 GO:0031134(sister chromatid biorientation)|GO:0032133(chromosome passenger complex)|GO:0004674(protein serine/threonine kinase activity)|GO:0051316(attachment of spindle microtubules to kinetochore involved in meiotic chromosome segregation)|GO:0090267(positive regulation of mitotic cell cycle spindle assembly checkpoint) complex portal:CPX-1900(complex-primary)|intenz:2.7.11.1(identity) Serine/threonine kinase complex which ensures chromosome bi-orientation on the mitotic spindle during metaphase by phosphorylating multiple kinetochore components. It destabilizes monopolar attachments by phosphorylating key proteins at the kinetophore. The opposing Chromosomal Passenger complex and Glc7 (P32598) activities ensure that chromosomes achieve a bipolar attachment to the spindle. Monopolar attachments do not produce tension across sister kinetochores (and the complex may act by sensing this absence of tension). The Chromosome passenger complex is conserved from yeast to man and is an essential regulator of diverse aspects of mitosis that ensure faithful chromosome segregation. The complex undergoes changes in its localization throughout mitosis: in early mitosis it presumably localizes to chromosome arms while later in metaphase it is found at the centromere. At anaphase onset it re-localizes to mitotic spindle microtubules accumulating in the midbody in late anaphase where it promotes spindle disassembly and cytokinesis. In budding yeast it seems to follow the positive ends of depolimerizing microtubules in late anaphase. It also plays a role in contractile ring formation and regulation of abscission in cytokinesis. IPL1 binds the N-terminal domain of SLI15, while the C-terminal domain of Sli15 forms a three-helix bundle with the other two regulatory components, BIR1 and NBL1. The size of the complex is about 1.5 MD by gel filtration indicating either elongated shape or oligomerization. - - - - - - psi-mi:"MI:0486"(UniProt) P38283(0)|P38991(0)|P47134(0)|Q3E7Y6(0) +CPX-1901 Peroxisomal receptor export module complex PEX1/PEX6/PEX15 complex|REM complex 559292 P24004(3)|P33760(3)|Q08215(3) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-6110058 GO:0005779(integral component of peroxisomal membrane)|GO:1904949(ATPase complex)|GO:0016887(ATPase activity)|GO:0016562(protein import into peroxisome matrix, receptor recycling) complex portal:CPX-1901(complex-primary)|pubmed:31652724(see-also)|pubmed:22500805(see-also) Processive protein translocase that mediates the ATP-dependent relocation and recycling of the peroxisomal targeting signal import receptor PEX5 (P35056) from the peroxisomal membrane to the cytosol, where it is then available for another round of protein import. The PEX1-PEX6 heterohexamer acts as a p97/CDC48-like ATPase that threads monoubiquitinated PEX5 through its central pore. PEX1-PEX6 form a hetero-hexameric ring with alternating PEX1 and PEX6 subunits and a large central pore. The PEX1-PEX6 heterohexamer is recruited to the peroxisomal membrane via a nucleotide-dependent interaction of PEX6 with the cytosolic domain of the tail-anchored membrane protein PEX15. Heterononamer - - - - - psi-mi:"MI:0469"(IntAct) P24004(3)|P33760(3)|Q08215(3) +CPX-1903 Perxosomal PEX2-PEX10-PEX12 ubiquitin ligase complex RING ubiquitin ligase Pex2/Pex10/Pex12 complex 559292 P32800(0)|Q04370(0)|Q05568(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-6112864 GO:0000151(ubiquitin ligase complex)|GO:0004842(ubiquitin-protein transferase activity)|GO:0016567(protein ubiquitination)|GO:0016558(protein import into peroxisome matrix) complex portal:CPX-1903(complex-primary)|pubmed:22471590(see-also)|pubmed:20079383(see-also) Ubiquitin-ligase which is a central component of the peroxisomal matrix protein import machinery. Ubiquinates the peroxisomal import -receptor, PEX5 (P35056), and promotes its recycling. - - - - - - - psi-mi:"MI:0469"(IntAct) P32800(0)|Q04370(0)|Q05568(0) +CPX-1904 Peroxisomal PEX13-PEX14-PEX17 docking complex Pex17-Pex14 docking complex 559292 P40155(0)|P53112(0)|P80667(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:1990415(Pex17p-Pex14p docking complex)|GO:0016560(protein import into peroxisome matrix, docking)|GO:0005778(peroxisomal membrane) complex portal:CPX-1904(complex-primary)|pubmed:20079383(see-also) Facilitates the peroxoisomal-membrane docking of cargo-loaded, peroxisomal targeting signal type 1 (PTS1) and PTS2 proteins. Proteins designated for peroxisomes are synthezised on cytosolic ribosomes and are recognised by the receptor PEX5 (P35056) via their PTS1 or the PEX7-PEX18 receptor complex via their PTS2 This receptor-cargo-complexes bind to the docking-complex at the peroxisomal membrane. It is assumed that the binding between the docking complex and cargo-loaded receptors leads to the formation of a transient pore. - - - - - - - psi-mi:"MI:0469"(IntAct) P40155(0)|P53112(0)|P80667(0) +CPX-1905 Peroxisomal PEX7-PEX18 receptor complex - 559292 P38855(0)|P39108(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-1392430 GO:0038024(cargo receptor activity)|GO:0005778(peroxisomal membrane)|GO:0005053(peroxisome matrix targeting signal-2 binding)|GO:0016558(protein import into peroxisome matrix)|GO:0005737(cytoplasm)|GO:0062137(cargo receptor complex) complex portal:CPX-1905(complex-primary)|pubmed:9864360(see-also)|pubmed:20079383(see-also) Receptor complex which recognises peroxisomal targeting signal type 2 containing proteins synthezised on cytosolic ribosomes. The receptor-cargo complex is then transported from the cytosol to the peroxisomal docking complex (CPX-1904). - - - - - - - psi-mi:"MI:0469"(IntAct) P38855(0)|P39108(0) +CPX-1906 Peroxisomal PEX7-PEX21 receptor complex - 559292 P39108(0)|P50091(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-16063037 GO:0062137(cargo receptor complex)|GO:0005053(peroxisome matrix targeting signal-2 binding)|GO:0016558(protein import into peroxisome matrix)|GO:0005737(cytoplasm)|GO:0005778(peroxisomal membrane)|GO:0038024(cargo receptor activity) pubmed:23812376(see-also)|pubmed:9864360(see-also)|complex portal:CPX-1906(complex-primary)|pubmed:20079383(see-also) Receptor complex which recognises peroxisomal targeting signal type 2 containing proteins synthezised on cytosolic ribosomes. The receptor-cargo complex is then transported from the cytosol to the peroxisomal docking complex (CPX-1904). - - - - - - - psi-mi:"MI:0469"(IntAct) P39108(0)|P50091(0) +CPX-1939 TRAPPII protein complex Transport protein particle II complex 559292 P32613(2)|P32893(2)|P36149(4)|P38334(2)|Q03337(2)|Q03630(2)|Q03660(2)|Q03784(2)|Q04183(2)|Q99394(2) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-6550305 GO:0006891(intra-Golgi vesicle-mediated transport)|GO:0042147(retrograde transport, endosome to Golgi)|GO:1990071(TRAPPII protein complex)|GO:0005085(guanyl-nucleotide exchange factor activity) complex portal:CPX-1939(complex-primary)|pubmed:22669257(see-also)|emdb:5213(identity)|emdb:5214(identity) Tethering complexes which provide the initial recognition event that links a particular vesicle with its target membrane. Participates in intra-Golgi and endosome-Golgi transport. Binds to a component of the COPI coat. BET3, BET5, TRS23, and TRS31 create a catalytic site for promoting GDP/GTP exchange in YPT1. The estimated size of TRAPPII is most consistent with the formation of a stable dimeric complex. EMD studies suggest that the nine TRAPPII components form a core complex that dimerizes into a three-layered, diamond-shaped structure. The three TRAPPII-specific subunits cap the ends and form the middle layer responsible for dimerization. Hetero 22-mer - - - - - psi-mi:"MI:0469"(IntAct) P32613(2)|P32893(2)|P36149(4)|P38334(2)|Q03337(2)|Q03630(2)|Q03660(2)|Q03784(2)|Q04183(2)|Q99394(2) +CPX-1940 TRAPPI protein complex TRAPPI|Transport protein particle I complex 559292 P36149(2)|P38334(1)|Q03337(1)|Q03630(1)|Q03784(1)|Q99394(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-1172781 GO:1990070(TRAPPI protein complex)|GO:0006888(ER to Golgi vesicle-mediated transport)|GO:0005085(guanyl-nucleotide exchange factor activity) complex portal:CPX-1940(complex-primary)|pubmed:22669257(see-also) Tethering complexes which provide the initial recognition event that links a particular vesicle with its target membrane. Participates in ER-Golgi transport and is a guanine nucleotide exchange factor for the Rab protein YPT1 (P01123). BET3 binds the SEC23 (P15303) subunit of the coat protein II (COPII) coat. BET3, BET5, TRS23, and TRS31 create a catalytic site for promoting GDP/GTP exchange in YPT1. The seven globular subunits arrange side by side to generate a flat and elongated molecule with two extensive surfaces. Heteroheptamer - - - - - psi-mi:"MI:0469"(IntAct) P36149(2)|P38334(1)|Q03337(1)|Q03630(1)|Q03784(1)|Q99394(1) +CPX-1947 Methionyl glutamyl tRNA synthetase complex Arc1p-aminoacyl-tRNA synthetase complex: Arc1-Gus1-Mes1|Arc1-GluRS-MetRS|G4P1-SYEC-SYMC complex 559292 CHEBI:29173(1)|CHEBI:29175(1)|P00958(1)|P46655(1)|P46672(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-6555962 GO:0006431(methionyl-tRNA aminoacylation)|GO:0017102(methionyl glutamyl tRNA synthetase complex)|GO:0004818(glutamate-tRNA ligase activity)|GO:0004825(methionine-tRNA ligase activity)|GO:0005524(ATP binding)|GO:0006424(glutamyl-tRNA aminoacylation) wwpdb:2hrk(subset)|wwpdb:2hsm(subset)|complex portal:CPX-1947(complex-primary)|intenz:6.1.1.17(identity)|intenz:6.1.1.10(identity) Catalyzes the aminoacylation of tRNAs by their cognate amino acid. Arc1p makes contact with MetRS and GluRS through its amino-terminal domain, while its carboxy-terminal contains a tRNA-binding domain. As a result of the formation of this complex, cognate tRNAs are bound with high affinity and aminoacylation efficiency is increased. The ternary complex of MetRS and GluRS with ARC1has an extended star-like shape, implying possible flexibility of the complex. Formation of the pentameric complex results in a significant comaction of this structure, believed to be due to the interactions of negatively charged tRNA backbones with the positively charged tRNA-binding domains of the synthetases. ARC1 appears to act as an intermolecular bridge between tRNA and the synthetases, bringing the reaction partners in close contact and, probably, orienting the tRNA so that the identity elements in the anticodon loop and the amino acid acceptor helix are correctly presented to the enzyme Heteropentamer - - - - - psi-mi:"MI:0469"(IntAct) P00958(1)|P46655(1)|P46672(1) +CPX-2091 DNA polymerase alpha:primase complex DPOLA-DPOA2-PRI1-PRI2 complex|Alpha DNA polymerase:primase complex|heterotetrameric polymerase alpha holoenzyme|pol-prim|primosome|Pol alpha-primase complex|polymerase alpha-primase complex 559292 CHEBI:49883(1)|P10363(1)|P13382(1)|P20457(1)|P38121(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-849030 GO:0003899(DNA-directed 5'-3' RNA polymerase activity)|GO:0006270(DNA replication initiation)|GO:0005658(alpha DNA polymerase:primase complex)|GO:0003697(single-stranded DNA binding) wwpdb:3flo(subset)|complex portal:CPX-2091(complex-primary)|pubmed:32379761(see-also)|rhea:RHEA:22508(identity)|intenz:2.7.7.7(identity)|pubmed:12806117(see-also) Initiates DNA replication by synthesizing short RNA primers on the leading and lagging strand templates in a minimum of five steps: template binding, NTP binding, dinucleotide formation, extension to a functional RNA primer, and primer transfer to the POLA catalytic site for elongation into hybrid primers of about 35 nucleotides. - Heterotetramer - - - - - psi-mi:"MI:0469"(IntAct) P10363(1)|P13382(1)|P20457(1)|P38121(1) +CPX-2101 DNA polymerase delta complex DNA polymerase delta heterotrimer|Pol delta 559292 CHEBI:49883(1)|P15436(1)|P46957(1)|P47110(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-22186064 GO:0043625(delta DNA polymerase complex)|GO:0003887(DNA-directed DNA polymerase activity)|GO:0006259(DNA metabolic process)|GO:0003690(double-stranded DNA binding) complex portal:CPX-2101(complex-primary)|rhea:RHEA:22508(identity)|wwpdb:6p1h(identity)|emdb:EMD-20235(identity)|pubmed:31582849(see-also)|intenz:2.7.7.7(identity) Believed to be the major polymerase for the elongation of both leading and lagging strands of chromosomal DNA in eukaryotic cells. Required for Okazaki fragment maturation together with Fen1 and proliferating cell nuclear antigen (PCNA). The 3'-5'-exonuclease activity of DNA polymerase delta is important for this process. Also involved in telomerase-mediated telomere addition and participates in several DNA repair pathways The regulatory subunits (POL31 and POL32) lie next to the exonuclease domain of POL3 but do not bind DNA. Heterotrimer - - - - - psi-mi:"MI:0469"(IntAct) P15436(1)|P46957(1)|P47110(1) +CPX-2110 DNA polymerase epsilon complex DNA polymerase epsilon heterotetramer|Pol epsilon 559292 CHEBI:49883(1)|P21951(1)|P24482(1)|P27344(1)|Q04603(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-866653 GO:0008622(epsilon DNA polymerase complex)|GO:0003887(DNA-directed DNA polymerase activity)|GO:0006261(DNA-dependent DNA replication)|GO:0003690(double-stranded DNA binding) complex portal:CPX-2110(complex-primary)|rhea:RHEA:22508(identity)|pubmed:12806123(see-also)|intenz:2.7.7.7(identity) Believed to play a role in the elongation of both leading and lagging strands of chromosomal DNA in eukaryotic cells. Required for DNA replication, DNA repair, transcriptional silencing and sister-chromatid cohesion. - Heterotetramer - - - - - psi-mi:"MI:0469"(IntAct) P21951(1)|P24482(1)|P27344(1)|Q04603(1) +CPX-2112 Telosome Rap1-Rif1-Rif2 telosome|Rap1-Rif1-Rif2 telomere cap 559292 EBI-8769060(0)|P11938(0)|P29539(0)|Q06208(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0070187(shelterin complex)|GO:0042162(telomeric DNA binding)|GO:0000723(telomere maintenance)|GO:0031936(negative regulation of chromatin silencing) complex portal:CPX-2112(complex-primary)|wwpdb:4BJT(subset)|wwpdb:4BJ5(subset) A protective cap that inhibits telomerase, counteracts SIR-mediated transcriptional silencing, and prevents inadvertent recognition of telomeres as DNA double-strand breaks. Rif1 and Rif2 have separable and independent Rap1-binding epitopes, allowing Rap1 recruitment and binding over large distances (42-110 A). Rif1 tetramerization and Rif2 polymerization modules give rise to a higher-order architecture that interlinks Rap1 units. - - - - - - psi-mi:"MI:0469"(IntAct) P11938(0)|P29539(0)|Q06208(0) +CPX-2122 Swr1 chromatin remodelling complex Swr1 complex 559292 P31376(0)|P35817(0)|P38326(0)|P53201(0)|P53930(0)|P60010(0)|P80428(0)|Q03388(0)|Q03433(0)|Q03940(0)|Q05471(0)|Q06707(0)|Q12464(0)|Q12509(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-8789605 GO:0000812(Swr1 complex)|GO:0005524(ATP binding)|GO:0000785(chromatin)|GO:0006355(regulation of transcription, DNA-templated)|GO:0140658(ATP-dependent chromatin remodeler activity)|GO:0031491(nucleosome binding) complex portal:CPX-2122(complex-primary)|pubmed:24034246(see-also)|rhea:RHEA:13065(identity)|emdb:EMD-3607(identity)|intenz:3.6.4.12(identity)|emdb:EMD-5626(identity)|pubmed:17316710(see-also) ATP-dependent chromatin-remodeling complex. SWR1 replaces the canonical H2A/H2B dimer at nucleosomes flanking histone-depleted regions, such as promoters, with a variant histone H2A.Z/H2B dimer. H2A.Z has been shown to affect the stability of its host nucleosome, higher-order chromatin folding, and recruitment of transcriptional factors SWR1 contains a single heterohexameric Rvb1/Rvb2 ring that, together with the catalytic subunit Swr1, brackets two independently assembled multisubunit modules. The N-terminal half of the Swr1 polypeptide contains the helicase-SANT-associated (HSA) domain and recruits the Bdf1-Arp4-Act1-Swc4-Yaf9-Swc7 module, probably involved in the targeting and binding of SWR1 to hyper-acetylated nucleosomes. The core ATPase domain resides in the C-terminal half of Swr1 and binds Swc3-Swc2(vps72)-Arp6-Swc6(vps71) which binds the H2A.Z/H2B dimer, which is to be incorporated into the nucleosome. - - - - - - psi-mi:"MI:0469"(IntAct) P31376(0)|P35817(0)|P38326(0)|P53201(0)|P53930(0)|P60010(0)|P80428(0)|Q03388(0)|Q03433(0)|Q03940(0)|Q05471(0)|Q06707(0)|Q12464(0)|Q12509(0) +CPX-2143 Hpa2 acetyltransferase Hpa2 complex 559292 CHEBI:15351(2)|Q06592(4) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-1252209 GO:1990331(Hpa2 acetyltransferase complex)|GO:0032917(polyamine acetylation)|GO:0010484(H3 histone acetyltransferase activity)|GO:0010485(H4 histone acetyltransferase activity)|GO:0043966(histone H3 acetylation)|GO:0043967(histone H4 acetylation)|GO:0005634(nucleus) wwpdb:1QSO(identity)|complex portal:CPX-2143(complex-primary)|wwpdb:1qsm(identity)|intenz:2.3.1.48(identity) Acetyltransferase which catalyzes the transfer of an acetyl group from acetyl-CoA to an acceptor residue on histones H-3 and H-4 and also on polyamines. May also acetylate certain small basic proteins. Two Hpa2 dimers are held together by interaction between the bound acetyl-CoA molecules. Homotetramer - - - - - psi-mi:"MI:0469"(IntAct) Q06592(4) +CPX-2146 SYP1 endocytic adapter complex - 559292 P25623(2) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-7189718 GO:1990252(Syp1 complex)|GO:0045807(positive regulation of endocytosis)|GO:0009826(unidimensional cell growth)|GO:0007117(budding cell bud growth)|GO:0005935(cellular bud neck)|GO:0061645(endocytic patch) complex portal:CPX-2146(complex-primary)|pubmed:19713939(see-also)|wwpdb:3g9g(identity) Acts as a component of the machinery that drives clathrin-mediated endocytosis in budding yeast. Plays a role in the distribution of endocytic sites. Recruits Ede1 (P34216) which is important for endocytic site formation. Negatively regulates the WAS-Arp2/3 complex that helps choreograph the precise timing of actin assembly during endocytosis. Also functions in polarized cell growth. Crescent-shaped homodimer. Two monomers related by a two-fold symmetry axis in the crystal interact tightly to form an antiparallel dimer with an extensive buried surface area. Homodimer - - - - - psi-mi:"MI:0471"(MINT) P25623(2) +CPX-2147 Ire1 serine/threonine-protein kinase/endoribonuclease complex Ire1 oligomer|Serine/threonine-protein kinase/endoribonuclease IRE1 559292 P32361(2) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-1633604 GO:0036290(protein trans-autophosphorylation)|GO:1990332(Ire1 complex)|GO:0004521(endoribonuclease activity)|GO:0004674(protein serine/threonine kinase activity)|GO:0005524(ATP binding)|GO:0098787(mRNA cleavage involved in mRNA processing)|GO:0030176(integral component of endoplasmic reticulum membrane)|GO:0036498(IRE1-mediated unfolded protein response)|GO:0051082(unfolded protein binding)|GO:0043620(regulation of DNA-templated transcription in response to stress) complex portal:CPX-2147(complex-primary)|rhea:RHEA:17989(identity)|rhea:RHEA:46608(identity)|wwpdb:3SDM(identity)|wwpdb:3SDJ(identity)|wwpdb:3lj2(identity)|wwpdb:3LJ1(identity)|wwpdb:3LJ0(identity)|wwpdb:3FBV(identity)|pubmed:19079236(see-also)|intenz:2.7.11.1(identity)|intenz:3.1.26(identity)|wwpdb:2RIO(identity) Endoplasmic reticulum localized, type-I transmembrane homodimer which forms in response to the accumulation of unfolded protein in the ER and evokes the unfolded protein response (UPR) by splicing the mRNA encoding master transcriptional regulator of the UPR, HAC1 (P41546). IRE1 cleaves a single phosphodiester bond in each of two RNA hairpins (with non-specific base paired stems and loops of consensus sequence CNCNNGN, where N is any base) to remove an intervening intron from the target transcript. IRE1 auto-activates via transphosphorylation following binding of unfolded proteins to its N-termini. Dimerization promotes the juxtapositioning of two cytoplasmic kinase domains in a face to face manner that facilitates trans-autophosphorylation on regulatory sites within the activation segment. Phosphorylation enables nucleotide binding which in turn enables a back-to-back dimer configuration, generating a large catalytic surface that is fully competent for ribonuclease function. Homodimer - - - - - psi-mi:"MI:0469"(IntAct) P32361(2) +CPX-2148 Phosphatidylinositol transporter complex PDR16 complex 559292 P53860(2) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-8517707 GO:1902556(phosphatidylinositol transporter complex)|GO:0008526(phosphatidylinositol transfer activity)|GO:0005811(lipid droplet)|GO:0035091(phosphatidylinositol binding)|GO:0032934(sterol binding) complex portal:CPX-2148(complex-primary)|wwpdb:4J7P(identity)|wwpdb:4M8Z(identity)|wwpdb:4J7Q(identity)|pubmed:24403601(see-also)|wwpdb:4FMM(identity) Phosphatidylinositol transfer homodimer a lipid droplet-associated protein that inhibits lipid mobilization from these particles. May assist in shuttling sterols or their intermediates, between membranes or, alternatively, between sterol biosynthetic enzymes or complexes. Required for the resistance of yeast cells to azole antifungals. Binding of phosphatidylinositol (PI) may destabilize the homodimer causing a conversion to the monomer, possibly with PI still bound. Homodimer - - - - - psi-mi:"MI:0471"(MINT) P53860(2) +CPX-2156 Chaperonin-containing T-complex Cytosolic chaperonin containing TCP1|TriC|TCP-1 ring complex|cytosolic chaperonin-containing TCP-1|Cytosolic chaperonin CCT complex|CCT 559292 CHEBI:15422(16)|P12612(2)|P39076(2)|P39077(2)|P39078(2)|P39079(2)|P40413(2)|P42943(2)|P47079(2) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-6994495 GO:0005832(chaperonin-containing T-complex)|GO:0051082(unfolded protein binding)|GO:0051086(chaperone mediated protein folding independent of cofactor) complex portal:CPX-2156(complex-primary)|pubmed:21701561(see-also)|wwpdb:4v81(identity) Essential chaperonin that uses ATP cycling to facilitate protein folding. TCP1 displays a classic chaperonin architecture, with two heterogeneous 8-membered rings stacked back-to-back, enclosing a folding cavity. The two rings each contain eight different subunits that form a double-toroid. Each ring encloses a cavity volume of approximately 145 000 A E-3. The N- and C-termini of all subunits, except one, come together on the inside of the ring, in a network of beta-sheets at the ring-ring interface, which forms the 'cavity floor'. Mol. wt = approximately 850 to 900 kDa Hexadecameric - - - - - psi-mi:"MI:0471"(MINT) P12612(2)|P39076(2)|P39077(2)|P39078(2)|P39079(2)|P40413(2)|P42943(2)|P47079(2) +CPX-2225 Myosin class V complex, MYO2 variant Unconventional myosin V complex|Myosin class 5 complex|Myo5 complex 559292 P06787(8)|P19524(2)|P53141(4) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0005524(ATP binding)|GO:0016887(ATPase activity)|GO:0003779(actin binding)|GO:0030050(vesicle transport along actin filament)|GO:0000146(microfilament motor activity)|GO:0031475(myosin V complex) pubmed:24467403(see-also)|complex portal:CPX-2225(complex-primary)|wwpdb:1m46(subset)|wwpdb:1m45(subset)|wwpdb:1n2d(subset) Building block of the class V myosin processive molecular motor involved in a range of organelle-transporting functions, including the transport of vacuoles and mRNA. The myosin heavy chain motor domain mediates the ATP-dependent interaction with the F-actin cytoskeleton. The myosin neck region with the bound light chains acts as a rigid lever arm that amplifies movements within the myosin motor domain into a large mechanical stroke that directionally propels the myosin along the actin filament. Myosin V has a high duty cycle, i.e. remains attached to actin for a large fraction of the mechanochemical cycle due to the slow rate of ADP release, the rate-limiting step in the ATPase cycle. This kinetic adaptation allows myosin V to take multiple steps without dissociating from the actin filament. Myosin V can take large steps of approximately 36nm, a distance equal to the helical repeat of the actin filament allowing Myosin V to walk in a straight line on the actin filament, in a hand-over-hand fashion. MYO2 contains an N‐terminal ‘head’ or motor domain, containing the actin‐binding and ATP catalytic sites, followed by an extended ‘neck’ domain formed by six in‐tandem IQ motifs. Following the neck is the ‘tail’ domain, which contains a region predicted to form a coiled‐coil and a C‐terminal globular domain. The IQ motifs constitute the binding sites for Ca2+‐free (or apo) Calmodulin (CaM) and CaM‐like light chains. IQ motifs are approximately 25 amino acids long with the consensus sequence IQxxxRGxxxR. Apo‐CaM is the primary light chain of myosin V, occupying approximately four out of the six IQ sites, however binding of the light chain MLC1 is essential. - - - - - - psi-mi:"MI:0469"(IntAct) P06787(8)|P19524(2)|P53141(4) +CPX-2262 26S Proteasome complex Proteasome Activator 559292 O13563(1)|O94742(1)|P21242(1)|P21243(1)|P22141(1)|P23638(1)|P23639(1)|P23724(1)|P25043(1)|P25451(1)|P30656(1)|P30657(1)|P32379(1)|P32496(1)|P32565(1)|P33297(1)|P33298(1)|P33299(1)|P38624(1)|P38764(1)|P38886(1)|P40016(1)|P40302(1)|P40303(1)|P40327(1)|P43588(1)|P53549(1)|Q01939(1)|Q04062(1)|Q06103(1)|Q08723(1)|Q12250(1)|Q12377(1) ECO:0000353(physical interaction evidence used in manual assertion) - GO:0000502(proteasome complex)|GO:0043161(proteasome-mediated ubiquitin-dependent protein catabolic process)|GO:0004298(threonine-type endopeptidase activity)|GO:0004843(thiol-dependent ubiquitin-specific protease activity)|GO:0016887(ATPase activity) intenz:3.4.25.1(identity)|wwpdb:4cr4(identity)|emdb:2596(identity)|wwpdb:4cr3(identity)|emdb:2595(identity)|wwpdb:3JCK(subset)|wwpdb:3JCO(identity)|wwpdb:3JCP(identity)|wwpdb:4cr2(identity)|emdb:2594(identity)|intenz:3.4.19.12(identity)|complex portal:CPX-2262(complex-primary)|pubmed:26643069(see-also)|wwpdb:2f16(subset)|wwpdb:2gpl(subset)|wwpdb:2zcy(subset)|wwpdb:3hye(subset)|wwpdb:1g0u(subset)|wwpdb:3bdm(subset)|wwpdb:3dy3(subset)|wwpdb:3dy4(subset)|wwpdb:3gpw(subset)|wwpdb:3gpt(subset)|wwpdb:1z7q(subset)|wwpdb:3e47(subset)|wwpdb:3d29(subset)|wwpdb:1jd2(subset)|wwpdb:2fak(subset)|wwpdb:4v7o(subset)|wwpdb:1g65(subset)|wwpdb:1ryp(subset)|wwpdb:3gpj(subset) Multi-enzyme complex that functions as the primary degradation machinery for the selective turnover of surplus or damaged proteins within the cell. Proteins targeted for degradation are covalently labeled with polyubiquitin chains which are recognized and removed by the proteasome. The core contains the protease active sites (chymotrypsin-like, trypsin-like and peptidylglutamyl-peptide hydrolyzing) that perform the proteolysis reactions in an internal chamber. The regulatory particles act as a discriminating gateway for potential substrates. The base drives the mechanical substrate unfolding and translocation of the unstructured polypeptides into the degradation chamber of the core peptidase. The lid contains the deubiquitinating enzyme (DUB) RPN11 that cleaves polyubiquitin chains from targeted substrates as an essential step in proteasomal substrate processing. The 26S proteasome consists of one 20S core particle and two 19S regulatory particles (RPs). The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two outer rings of the core are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The RP is divided into the lid and base assembly intermediates. The lid comprises nine RPN subunits (RPN3/5/6/7/8/9/11/12/SEM1) and the base comprises three RPN subunits (RPN1/2/13) and six AAA+ ATPases (RPT1-6) which form a heterohexameric ring. RPN10, which consists of an N-terminal von Willebrand factor A domain and multiple C-terminal ubiquitin-interacting motifs (UIM), connects the lid and the base. Molecular weight 2.5 MDa 33-mer heteromer - - - - - psi-mi:"MI:0469"(IntAct) O13563(1)|O94742(1)|P21242(1)|P21243(1)|P22141(1)|P23638(1)|P23639(1)|P23724(1)|P25043(1)|P25451(1)|P30656(1)|P30657(1)|P32379(1)|P32496(1)|P32565(1)|P33297(1)|P33298(1)|P33299(1)|P38624(1)|P38764(1)|P38886(1)|P40016(1)|P40302(1)|P40303(1)|P40327(1)|P43588(1)|P53549(1)|Q01939(1)|Q04062(1)|Q06103(1)|Q08723(1)|Q12250(1)|Q12377(1) +CPX-2267 SOD1-CCS1 superoxide dismutase heterodimer - 559292 CHEBI:29036(2)|CHEBI:29105(1)|P00445(1)|P40202(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-15500104 GO:1902693(superoxide dismutase complex)|GO:0016532(superoxide dismutase copper chaperone activity)|GO:0015680(protein maturation by copper ion transfer)|GO:0019430(removal of superoxide radicals) complex portal:CPX-2267(complex-primary)|rhea:RHEA:20696(identity)|pubmed:11524675(see-also)|pubmed:9295278(see-also)|wwpdb:1jk9(identity)|intenz:1.15.1.1(identity) Complex formation results in the activationof the antioxidant enzyme copper, zinc superoxide dismutase,SOD1 which protects cells against oxygen stress and reactive oxygen species by converting superoxide radicals into water and hydrogen peroxide. SOD1 (CPX-2896) activation involves insertion of copper and oxidation of an intrasubunit disulfide bond. Insertion of copper is required for any enzymatic activity. Oxidation of the disulfide bond is required to increase the enzymatic activity from approximately 10 % in disulfide-reduced SOD1 to 100 % in disulfide-oxidized SOD1. The copper chaperone, CCS1 (CPX-2895), both delivers the copper and oxidises the disulfide bond. Zinc-binding at His-16 of CCS1 and Glu-43 of apo-SOD1 is required for this heterodimerization. Heterodimer - - - - - psi-mi:"MI:0469"(IntAct) P00445(1)|P40202(1) +CPX-2268 TIM9-TIM10 mitochondrial intermembrane space protein transporter complex Tim9-Tim10 complex 559292 O74700(3)|P87108(3) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-1200706 GO:0042719(mitochondrial intermembrane space protein transporter complex)|GO:0045039(protein import into mitochondrial inner membrane)|GO:0140318(protein transporter activity)|GO:0005758(mitochondrial intermembrane space) pubmed:19037098(see-also)|complex portal:CPX-2268(complex-primary)|wwpdb:3dxr(identity) Facilitates transport of hydrophobic precursors of a distinct subgroup of inner membrane proteins through the aqueous intermembrane space as they exit the TOM40 channel complex (CPX-474) in the outer membrane. Functions as a chaperone to maintain the hydrophobic membrane proteins in an import competent state and escort substrates to the TIM22 insertion complex (CPX-1629), which mediates protein insertion into the membrane.. Cross-links to the COOH-terminal domain of the essential import translocase protein TIM23 (P32897) and plays a key role in TIM23 import to the mitochondrial inner membrane. Forms a ring-like organization in which alternating Tim9 and Tim10 subunits are arranged like the blades of a propeller. Each subunit contains a central loop flanked by disulfide bonds that separate two extended N- and C-terminal helices. Buried salt-bridges between highly conserved lysine and glutamate residues connect alternating subunits. Mol. wt. = 70kDa. Heterohexamer. - - - - - psi-mi:"MI:0469"(IntAct) O74700(3)|P87108(3) +CPX-2371 TIM8-TIM13 mitochondrial intermembrane space protein transporter complex - 559292 P53299(3)|P57744(3) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-9083698 GO:0045039(protein import into mitochondrial inner membrane)|GO:0042719(mitochondrial intermembrane space protein transporter complex)|GO:0005739(mitochondrion)|GO:0005758(mitochondrial intermembrane space) complex portal:CPX-2371(complex-primary)|wwpdb:3cjh(identity) Facilitates transport of hydrophobic precursors of a distinct subgroup of inner membrane proteins through the aqueous intermembrane space as they exit the TOM40 channel complex (CPX-474) in the outer membrane. Plays a role in the import of a distinct subgroup of inner membrane proteins, functioning as a chaperone to maintain the hydrophobic membrane proteins in an import competent state and escort substrates to the TIM22 insertion complex (CPX-1629), which mediates protein insertion into the membrane. Cross-links to the COOH-terminal domain of the essential import translocase protein TIM23 (P32897) and plays a key role in TIM23 import to the mitochondrial inner membrane. Each subunit contains a central loop flanked by disulfide bonds that separate two extended N- and C-terminal helices. Buried salt-bridges between highly conserved lysine and glutamate residues connect alternating subunits. Mol. wt. = 70kDa. Heterohexamer - - - - - psi-mi:"MI:0469"(IntAct) P53299(3)|P57744(3) +CPX-2523 COPII vesicle coat complex COPII complex|Cytoplasmic coat protein complex II 559292 CHEBI:15996(0)|P15303(1)|P20606(0)|P38968(2)|P40482(0)|Q04491(1) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0070863(positive regulation of protein exit from endoplasmic reticulum)|GO:1902953(positive regulation of ER to Golgi vesicle-mediated transport)|GO:0030127(COPII vesicle coat)|GO:0005783(endoplasmic reticulum) wwpdb:1M2O(subset)|wwpdb:2QTV(subset)|wwpdb:4BZI(subset)|emdb:2428(subset)|wwpdb:1M2V(subset)|emdb:2429(subset)|emdb:2432(subset)|complex portal:CPX-2523(complex-primary)|wwpdb:2pm7(subset)|wwpdb:4bzk(subset)|emdb:2431(subset)|wwpdb:4bzj(subset)|emdb:2430(subset)|wwpdb:2pm6(subset)|wwpdb:3mzl(subset)|wwpdb:2pm9(subset) Mediates formation of the membrane vesicles that export newly synthesised proteins from the endoplasmic reticulum. Upon exchange of GDP for GTP (catalysed by SEC12), SAR1 exposes an N-terminal amphipathic helix that inserts into the outer ER membrane leaflet, promoting curvature. SAR1 recruits SEC23/24 to the membrane to form the inner layer of the COPII coat. SEC24 binds transport cargo while SEC23 interacts with SAR1 and recruits the outer COPII components (SEC13/31) that form a cage around the vesicle by self-assembling into a polyhedron. SEC16 may also be required for proper COPII coat assembly but its role has not been clearly defined. The inner and outer proteins each form lattice structures. Both coats may help to reshape the membrane, and the inner-coat and outer-coat lattices move with respect to each other. These flexible properties could allow the coat to assemble on membranes with different shapes and curvatures, forming COPII vesicles with distinct sizes and shapes that can carry a range of cargoes. - - - - - - psi-mi:"MI:0469"(IntAct) P15303(1)|P20606(0)|P38968(2)|P40482(0)|Q04491(1) +CPX-2541 MMS2-UBC13 ubiquitin ligase complex MMS2-UBC13 ubiquitin ligase complex 559292 P52490(1)|P53152(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-1031516 GO:0031372(UBC13-MMS2 complex)|GO:0004842(ubiquitin-protein transferase activity)|GO:0005524(ATP binding)|GO:0042275(error-free postreplication DNA repair) wwpdb:5OJW(identity)|complex portal:CPX-2541(complex-primary)|intenz:2.3.2.23(identity)|wwpdb:1JAT(identity) Ubiquitin ligase complex. Transfers the thioester-bound donor ubiquitin from Ubc13 onto the Mms2 catalytically inactive E2 variant. Functions in concert with RING E3 ubiquitin ligase RAD5 to catalyze the Lys-63-linked polyubiquitination of monoubiquitinated replication processivity factor PCNA (CPX-544). MMS2 positions the acceptor ubiquitin so that only Lys-63 approaches the active site cysteine of UBC13. This modification activates the recombination-like DNA damage-avoidance mechanism, in which the replicating polymerase avoids synthesis opposite damaged DNA by transient switching of the template, from the damaged DNA strand to the intact newly synthesized strand of the sister chromatid. - Heterodimer - - - - - psi-mi:"MI:0469"(IntAct) P52490(1)|P53152(1) +CPX-2566 Nucleosome, variant HTA1-HTB2 - 559292 CHEBI:4705(1)|P02294(2)|P02309(2)|P04911(2)|P61830(2) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-16751548 GO:0000786(nucleosome)|GO:0006333(chromatin assembly or disassembly)|GO:0005634(nucleus) complex portal:CPX-2566(complex-primary)|wwpdb:1id3(identity) Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. 1.65 tight superhelical turns of 147 base pairs of DNA are wrapped around a histone octamer to form the nucleosome core. The H3-H4 heterodimers pair to form a tetramer through interactions of a four-helix bundle (alpha2 and alpha3 of H3 from each dimer). The association of this (H3-H4)2 tetramer with DNA is the first step in nucleosome assembly. Each H2A-H2B heterodimer binds to the (H3-H4)2 tetramer via another, homologous, four-helix bundle (alpha2 and alpha3 from both H2B and H4), joining the H2B and H4 histone folds. - - - - - - psi-mi:"MI:0469"(IntAct) P02294(2)|P02309(2)|P04911(2)|P61830(2) +CPX-2660 DNA-directed RNA polymerase III complex Pol III|RNA Polymerase 3|RNA polymerase III 559292 CHEBI:18420(1)|CHEBI:29105(5)|P04051(1)|P07703(1)|P17890(1)|P20434(1)|P20435(1)|P20436(1)|P22139(1)|P22276(1)|P25441(1)|P28000(1)|P32349(1)|P32910(1)|P35718(1)|P36121(1)|P40422(1)|P47076(1)|Q04307(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-16185862 GO:0006383(transcription elongation from RNA polymerase III promoter)|GO:0006386(termination of RNA polymerase III transcription)|GO:0003727(single-stranded RNA binding)|GO:0005634(nucleus)|GO:0006384(transcription initiation from RNA polymerase III promoter)|GO:0001003(RNA polymerase III type 2 promoter sequence-specific DNA binding)|GO:0000992(polymerase III regulatory region sequence-specific DNA binding)|GO:0003899(DNA-directed RNA polymerase activity)|GO:0005666(DNA-directed RNA polymerase III complex) pubmed:23063749(see-also)|complex portal:CPX-2660(complex-primary)|intenz:2.7.7.6(identity)|wwpdb:2ckz(subset)|wwpdb:5fj9(identity)|emdb:EMD-3179(identity)|wwpdb:5fja(identity)|emdb:EMD-3180(identity)|wwpdb:5fj8(identity)|emdb:EMD-3178(identity) Catalyzes the transcription of RNA from an DNA template by acting as a nucleotidyl transferase that polymerizes ribonucleotides at the 3-prime end of an RNA transcript. Responsible for the transcription of genes encoding small structured RNAs such as tRNAs, the 7 SL lncRNA, spliceosomal U6 snRNA and ribosomal 5S RNA. Pol III machinery recognizes conserved promoter elements located within the transcribed region, generally the box A and box B sequences, which contribute to the D- and T-loops in the tRNA structure. RPC34, RPC31 and RPC82 play a role in transcription initiation whereas the RPC37-RPC53 heterodimer is crucial for the correct recognition of the termination signals of class III genes. RPC11 is required for RNA cleavage. Pol III is capable of reinitiating transcription more rapidly on the same gene after the first transcription cycle without being released (facilitated reinitiation), resulting in a higher initiation efficiency; this appears to require an RPC11-dependent conformational change of Pol III. The core complex is believed to assemble in the cytoplasm before being transported to the nucleus. Molecular weight of = approximately 0.7 MDa. The polymerase consists of a core element with a central large cleft forming the active center. The clamp element is connected to the core through a set of flexible switches and moves to open and close the cleft. The cleft is surrounded by an upper jaw and a lower jaw. The jaws are thought to grab the incoming DNA template. The fork loop 1 interacts with the RNA-DNA hybrid, possibly stabilizing it. The clamp head part of Pol III is enlarged compared to its Pol I (CPX-1664 ) and Pol II (CPX-2662). The depth of the DNA-binding cleft is also increased in comparison to Pol I and Pol II. Heteroheptadecamer - - - - - psi-mi:"MI:0469"(IntAct) P04051(1)|P07703(1)|P17890(1)|P20434(1)|P20435(1)|P20436(1)|P22139(1)|P22276(1)|P25441(1)|P28000(1)|P32349(1)|P32910(1)|P35718(1)|P36121(1)|P40422(1)|P47076(1)|Q04307(1) +CPX-2662 DNA-directed RNA polymerase II complex RNA polymerase II|Pol II|RNA polymerase 2 559292 CHEBI:18420(2)|CHEBI:29105(8)|CPX-1891(1)|P04050(1)|P08518(1)|P16370(1)|P20434(1)|P20435(1)|P20436(1)|P22139(1)|P27999(1)|P38902(1)|P40422(1) ECO:0000353(physical interaction evidence used in manual assertion) - GO:0000977(RNA polymerase II regulatory region sequence-specific DNA binding)|GO:0005634(nucleus)|GO:0005665(DNA-directed RNA polymerase II, core complex)|GO:0006367(transcription initiation from RNA polymerase II promoter)|GO:0006368(transcription elongation from RNA polymerase II promoter)|GO:0003899(DNA-directed RNA polymerase activity)|GO:0003727(single-stranded RNA binding) wwpdb:1Y14(subset)|wwpdb:3S16(subset)|wwpdb:3S17(subset)|wwpdb:3s1m(subset)|wwpdb:3S1N(subset)|wwpdb:3S1Q(subset)|wwpdb:3S1R(subset)|complex portal:CPX-2662(complex-primary)|emdb:EMD-8737(identity)|wwpdb:5vvs(identity)|wwpdb:1I6H(subset)|wwpdb:1k83(subset)|wwpdb:1r9s(subset)|wwpdb:1r9t(subset)|wwpdb:1sfo(subset)|wwpdb:1twa(subset)|wwpdb:1TWC(subset)|wwpdb:1TWF(subset)|wwpdb:1twg(subset)|wwpdb:2YU9(subset)|wwpdb:4A3B(identity)|wwpdb:4A3C(identity)|wwpdb:4a3d(identity)|wwpdb:4A3E(identity)|wwpdb:4A3F(identity)|wwpdb:4A3G(identity)|wwpdb:4A3I(identity)|wwpdb:4A3J(identity)|wwpdb:4A3K(identity)|wwpdb:4A3L(identity)|wwpdb:4A3M(identity)|wwpdb:4A93(identity)|wwpdb:4V1M(identity)|emdb:EMD-2784(identity)|wwpdb:4X67(subset)|wwpdb:4X6A(subset)|wwpdb:5C44(identity)|wwpdb:4Y52(subset)|wwpdb:4Y7N(subset)|wwpdb:5C3E(identity)|wwpdb:5C4A(identity)|wwpdb:5C4J(subset)|wwpdb:5C4X(identity)|wwpdb:3rzd(subset)|wwpdb:3rzo(subset)|wwpdb:3S14(subset)|wwpdb:3S15(subset)|wwpdb:3S2D(subset)|wwpdb:3S2H(subset)|wwpdb:1twh(subset)|wwpdb:2E2H(subset)|wwpdb:2NVQ(subset)|wwpdb:2NVT(subset)|wwpdb:2nvy(subset)|wwpdb:2NVX(subset)|wwpdb:2nvz(subset)|wwpdb:3gtg(subset)|wwpdb:3gtj(subset)|wwpdb:3gtk(subset)|wwpdb:3gtl(subset)|wwpdb:3gto(subset)|wwpdb:3gtp(subset)|wwpdb:3M3Y(subset)|wwpdb:3m4o(subset)|wwpdb:1i50(subset)|wwpdb:1i3q(subset)|wwpdb:1nik(identity)|wwpdb:3fki(identity)|wwpdb:3hox(identity)|wwpdb:2b63(identity)|wwpdb:3hov(identity)|wwpdb:2r92(identity)|wwpdb:2ja8(identity)|wwpdb:2r7z(identity)|wwpdb:3h3v(identity)|wwpdb:2b8k(identity)|wwpdb:2ja5(identity)|wwpdb:1wcm(identity)|wwpdb:3i4n(identity)|wwpdb:1y77(identity)|wwpdb:3hou(identity)|wwpdb:1y1w(identity)|wwpdb:2r93(identity)|wwpdb:3how(identity)|wwpdb:3hoz(identity)|wwpdb:3hoy(identity)|wwpdb:2ja6(identity)|wwpdb:3i4m(identity)|wwpdb:3po2(identity)|wwpdb:2ja7(identity)|wwpdb:1nt9(identity)|intenz:2.7.7.6(identity)|intact:EBI-7510175(identity) Catalyzes the transcription of RNA from a DNA template by acting as a nucleotidyl transferase that polymerizes ribonucleotides at the 3-prime end of an RNA transcript. Synthesizes precursors of mRNAs, and most snRNA and microRNAs. During a transcription cycle, Pol II, general transcription factors and the mediator complex (CPX-3226) assemble as the preinitiation complex (PIC) at the promoter. 11-15 base pairs of DNA surrounding the transcription start site are melted and the single-stranded DNA template strand of the promoter is positioned deeply within the central active site cleft of Pol II to form the open complex. After synthesis of about 30 bases of RNA, Pol II releases its contacts with the core promoter and the rest of the transcription machinery (promoter clearance) and enters the stage of transcription elongation in which it moves on the template as the transcript elongates. Pol II appears to oscillate between inactive and active conformations at each step of nucleotide addition. Pol II is composed of mobile elements that move relative to each other. The core element with the central large cleft comprises RPB3, RBP10, RPB11, RPB12 and regions of RPB1 and RPB2 forming the active center. The clamp element (portions of RPB1, RPB2 and RPB3) is connected to the core through a set of flexible switches and moves to open and close the cleft. The cleft is surrounded by jaws: an upper jaw formed by portions of RBP1, RPB2 and RPB9, and a lower jaw. The jaws are thought to grab the incoming DNA template. The fork loop 1 (RPB2) interacts with the RNA-DNA hybrid, possibly stabilizing it. Heterododecamer - - - - - psi-mi:"MI:0469"(IntAct) P04050(1)|P08518(1)|P16370(1)|P20433(1)|P20434(1)|P20435(1)|P20436(1)|P22139(1)|P27999(1)|P34087(1)|P38902(1)|P40422(1) +CPX-2800 Snf1 protein kinase complex variant SIP2 Snf1 serine/threonine protein kinase complex|AMPK|AMP-activated protein kinase complex 559292 P06782(1)|P12904(1)|P34164(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-2618363 GO:0070404(NADH binding)|GO:0031588(nucleotide-activated protein kinase complex)|GO:0030447(filamentous growth)|GO:0004674(protein serine/threonine kinase activity)|GO:0005524(ATP binding)|GO:0043531(ADP binding)|GO:1904547(regulation of cellular response to glucose starvation) complex portal:CPX-2800(complex-primary)|wwpdb:2qlv(identity)|pubmed:24483210(see-also)|wwpdb:3t4n(identity)|wwpdb:3tdh(identity)|wwpdb:3te5(identity)|intenz:2.7.11.1(identity) Energy sensor protein kinase complex, activated by glucose depletion. Regulates cellular energy metabolism by activating energy-producing pathways and inhibiting energy-consuming processes via derepression of glucose-repressed genes. Required for the diauxic shift, in which genes required for mitochondrial oxidative metabolism (normally repressed by glucose) are switched on; growth then resumes at a lower rate. Role in filamentous invasive growth, on glucose depletion, in haploid cells. The activity of this complex is modulated by reversible phosphorylation of SNF1 Thr-210 which increases in response to glucose starvation and correlates with large increases in cellular ADP-to-ATP and AMP-to-ATP ratios. Binding of ADP, but not AMP, to the complex protects against dephosphorylation of Thr-210, suggesting that ADP, rather than AMP, may be the critical activating signal. When glucose levels are high, the complex is cytoplasmic. Upon glucose depletion, SIP2-containing SNF1 remain in the cytosol. A central component of the heterotrimer interface is an eight-stranded, mostly antiparallel beta-sheet, formed with four strands from SNF1 (residues 531-586), three strands from SIP2 (residues 375-412) and one strand from SNF4 (residues 38-45). SNF4 binds two molecules of adenine nucleotide and NADH. SIP2 binds carbohydrates. Heterotrimer - - - - - psi-mi:"MI:0469"(IntAct) P06782(1)|P12904(1)|P34164(1) +CPX-2841 GRX6 iron-sulfur cluster assembly homodimer complex Class II iron-sulfur assembly complex, GRX6|Monothiol iron-sulfur assembly complex, GRX6|GRX6 Fe-S cluster assembly complex 559292 CHEBI:16856(2)|CHEBI:33737(1)|Q12438(2) ECO:0000353(physical interaction evidence used in manual assertion) wwpdb:5J3R GO:1990229(iron-sulfur cluster assembly complex)|GO:0016226(iron-sulfur cluster assembly)|GO:0055072(iron ion homeostasis) complex portal:CPX-2841(complex-primary)|pubmed:27710937(see-also)|pubmed:32910989(see-also) Reversibly binds [2Fe-2S] clusters and appears to play a role in Fe-S cluster assembly and trafficking, and in transferring an intact [2Fe-2S] cluster to an apo acceptor protein. - Homodimer - - - - - psi-mi:"MI:0469"(IntAct) Q12438(2) +CPX-2854 Elongation Factor eEF1 complex, variant CAM1 eEF1A-eEF1Ba-eEF1Bg1 complex|Eukaryotic elongation factor 1 complex 559292 P02994(2)|P29547(2)|P32471(2) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0005840(ribosome)|GO:0006414(translational elongation)|GO:0003746(translation elongation factor activity)|GO:0019003(GDP binding)|GO:0003924(GTPase activity)|GO:0005085(guanyl-nucleotide exchange factor activity)|GO:0005525(GTP binding)|GO:0005853(eukaryotic translation elongation factor 1 complex) pubmed:12972429(see-also)|pubmed:3528160(see-also)|pubmed:12008673(see-also)|complex portal:CPX-2854(complex-primary)|wwpdb:1g7c(subset)|wwpdb:1ijf(subset)|wwpdb:1ije(subset)|wwpdb:2b7c(subset)|wwpdb:1f60(subset)|wwpdb:2b7b(subset) Transports an aminoacylated-tRNA (aa-tRNA) to the ribosomal A-site during the elongation phase of protein synthesis. GTP bound to eEF1A (TEF1/2) is hydrolyzed upon codon-anticodon match between an aa-tRNA in the ribosomal RNA A-site and mRNA bound to the ribosome. Inactive eEF1A-GDP leaves the ribosome and must be recycled to eEF1A-GTP before binding another molecule of aa-tRNA. The guanine nucleotide exchange factor eEF1B catalyzes the exchange of GDP for GTP. Molecular weight=240kDa Heterohexamer - - - - - psi-mi:"MI:0469"(IntAct) P02994(2)|P29547(2)|P32471(2) +CPX-2894 Inositol phosphorylceramide synthase complex ICP synthase complex 559292 P36107(0)|Q06346(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-9084875 GO:0070916(inositol phosphoceramide synthase complex)|GO:0045140(inositol phosphoceramide synthase activity)|GO:0006673(inositol phosphoceramide metabolic process)|GO:0030148(sphingolipid biosynthetic process) complex portal:CPX-2894(complex-primary)|intenz:2(identity)|pubmed:19726565(see-also) Catalyzes the addition of a phosphorylinositol group onto the 1-OH position of ceramide to form inositol phosphorylceramide, an essential step in forming the inositol-phosphate head group of sphingolipids. Sphingolipids are a structurally diverse class of membrane lipids implicated in a number of cell signaling functions. - - - - - - - psi-mi:"MI:0469"(IntAct) P36107(0)|Q06346(0) +CPX-2895 Superoxide dismutase 1 copper chaperone - 559292 CHEBI:29036(4)|P40202(2) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-15489093 GO:0016532(superoxide dismutase copper chaperone activity)|GO:0006825(copper ion transport)|GO:0101031(chaperone complex)|GO:0015680(protein maturation by copper ion transfer) complex portal:CPX-2895(complex-primary)|wwpdb:1qup(identity)|pubmed:10426947(see-also) Copper chaperone for superoxide dismutase which delivers copper to the [Cu-Zn] superoxide dismutase I (SOD1, CPX-2896) forming heterodimer (CPX-2267). Insertion of copper is required for SOD1 enzymatic activity. Oxidation of an intramolecular disulfide bond is required to increase the enzymatic activity from approximately 10 % in disulfide-reduced SOD1 to 100 % in disulfide-oxidized SOD1. The copper chaperone, CCS1, both delivers the copper and oxidises the disulfide bond. - Homodimer - - - - - psi-mi:"MI:0469"(IntAct) P40202(2) +CPX-2896 [Cu-Zn] Superoxide dismutase complex Copper–zinc superoxide dismutase 559292 CHEBI:29036(2)|CHEBI:29105(2)|P00445(2) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-9097846 GO:1902693(superoxide dismutase complex)|GO:0004784(superoxide dismutase activity)|GO:0019430(removal of superoxide radicals) complex portal:CPX-2896(complex-primary)|rhea:RHEA:20696(identity)|wwpdb:1B4L(identity)|wwpdb:1B4T(identity)|wwpdb:1F18(identity)|wwpdb:1F1D(identity)|wwpdb:1F1G(identity)|wwpdb:1JCV(identity)|wwpdb:1YAZ(identity)|wwpdb:1YSO(identity)|wwpdb:2JCW(identity)|wwpdb:1F1A(identity)|pubmed:24061560(see-also)|intenz:1.15.1.1(identity) Catalyzes the breakdown of two superoxide molecules into dioxygen and hydrogen peroxide in two asymmetrical steps using an essential copper atom in the active site of the enzyme. Reduction of the oxidized Cu(II) form of the enzyme by superoxide, releasing dioxygen (reaction 1), alternates with oxidation of the reduced Cu(I) form by another superoxide anion and two protons, generating hydrogen peroxide (reaction 2). Protects the cell guard against free radical species produced during cellular metabolism. SOD1 acquires its copper by forming a heterodimer with the copper chaperone, CCS (CPX-2267), which also is responsible for formation of an intramolecular disulfide bond required to increase the enzymatic activity from approximately 10 % in disulfide-reduced SOD1 to 100 % in disulfide-oxidized SOD1. The copper chaperone, CCS1 (CPX-2895), both delivers the copper and oxidises the disulfide bond. There is also evidence of CCS-independent activation of SOD1. Each subunit contains one copper ion, one zinc ion, and an intrasubunit disulfide bond. Homodimer - - - - - psi-mi:"MI:0469"(IntAct) P00445(2) +CPX-2902 RAD6-RAD18 ubiquitin ligase complex UBC2-RAD18 ubiquitin ligase complex|RAD6-RAD18 complex|UBC2-RAD18 complex|RAD6/UBC2-Rad18 complex|RAD6/UBC2-RAD18 ubiquitin ligase complex 559292 P06104(1)|P10862(1) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0097505(Rad6-Rad18 complex)|GO:0003697(single-stranded DNA binding)|GO:0004842(ubiquitin-protein transferase activity)|GO:0005524(ATP binding)|GO:0006513(protein monoubiquitination)|GO:0042275(error-free postreplication DNA repair) complex portal:CPX-2902(complex-primary)|pubmed:7926769(see-also)|pubmed:9287349(see-also)|intenz:2.3.2.27(identity)|intenz:6.3.2.19(identity) Ubiquitin ligase complex invovled in post-replicative repair of damaged DNA. Mono-ubiquitinates PCNA at a highly conserved lysine, lys-164, in response to replication-stalling DNA damage. This promotes the recruitment of a class of specialized polymerases capable of using damaged DNA as a template for trans-lesion synthesis. Also plays a role in the prevention of spontaneous mutations caused by oxidation of guanine to 7,8-dihydo-8-oxoguanine, caused by free radicals and reactive oxygen species. P06104 is known as RAD6 or UBC2 Heterodimer. - - - - - psi-mi:"MI:0469"(IntAct) P06104(1)|P10862(1) +CPX-2910 BRE1-RAD6 ubiquitin ligase complex BRE1-RAD6 complex|BRE1-UBC2 complex|BRE1-RAD6/UBC2 complex|BRE1-UBC2 ubiquitin ligase complex|BRE1-RAD6/UBC2 ubiquitin ligase complex 559292 P06104(0)|Q07457(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-9101968 GO:0000724(double-strand break repair via homologous recombination)|GO:0042138(meiotic DNA double-strand break formation)|GO:0045944(positive regulation of transcription by RNA polymerase II)|GO:0040029(regulation of gene expression, epigenetic)|GO:1990302(Bre1-Rad6 ubiquitin ligase complex)|GO:0004842(ubiquitin-protein transferase activity)|GO:0000077(DNA damage checkpoint)|GO:0000722(telomere maintenance via recombination)|GO:0010390(histone monoubiquitination)|GO:0016574(histone ubiquitination) complex portal:CPX-2910(complex-primary)|pubmed:19531475(see-also)|intenz:2.3.2.27(identity)|pubmed:23028185(see-also)|intenz:2.3.2.23(identity) Ubiquitin ligase complex. Mono-ubiquitinates the histone H2B residue lysine-123. This provides a specific tag for epigenetic transcriptional activation in addition to modulating the formation of double-strand breaks during meiosis and being a prerequisite for DNA-damage checkpoint activation. Ubiquitination of lys-123 is a prerequisite for the subsequent di- and trimethylation of histone H3 on K4 and K79 which is important for telomeric gene silencing. A BRE1-associated protein, LGE1, is also required for H2B monoubiquitination and may be part of a larger complex. - - - - - - - psi-mi:"MI:0469"(IntAct) P06104(0)|Q07457(0) +CPX-2911 BRE1 E3 ubiquitin-protein ligase complex - 559292 Q07457(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-9101986 GO:0016881(acid-amino acid ligase activity)|GO:0006366(transcription from RNA polymerase II promoter)|GO:1990352(BRE1 E3 ubiquitin-protein ligase complex) complex portal:CPX-2911(complex-primary)|intenz:6.3.2(identity) E3 ubiquitin-protein ligase. Plays a required role in regulation of RNA polymerase II association with active genes. Homomeric - unpublished data in PMID: 19531475 suggests a homotetramer. Homo-oligomer - - - - - psi-mi:"MI:0469"(IntAct) Q07457(0) +CPX-2918 UBR1-RAD6 ubiquitin ligase complex UBR1-RAD6/UBC2 complex|UBR1-UBC2 ubiquitin ligase complex|UBR1-RAD6/UBC2 ubiquitin ligase complex|UBR1-RAD6 complex|UBR1-UBC2 complex 559292 P06104(0)|P19812(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-15752530 GO:0000209(protein polyubiquitination)|GO:1990303(UBR1-RAD6 ubiquitin ligase complex)|GO:0004842(ubiquitin-protein transferase activity)|GO:0071596(ubiquitin-dependent protein catabolic process via the N-end rule pathway) complex portal:CPX-2918(complex-primary)|intenz:2.3.2.27(identity)|pubmed:19164530(see-also) Ubiquitin ligase complex. Polyubiquitinates proteins containing unacetylated N-terminal residues causing their subsequent degradation by the proteasome as part of the Ac/N-End Rule pathway. Recognizes unacetylated N-terminal methionine if it is followed by a hydrophobic residue. Additionally, acts in an N-end rule independent manner as a component of a novel quality control pathway for proteins synthesized on cytosolic ribosomes - - - - - - - psi-mi:"MI:0469"(IntAct) P06104(0)|P19812(0) +CPX-2921 RSP5-BUL1 ubiquitin ligase complex - 559292 P39940(0)|P48524(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-7227680 GO:0034450(ubiquitin-ubiquitin ligase activity)|GO:0000209(protein polyubiquitination)|GO:0043162(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|GO:2000397(positive regulation of ubiquitin-dependent endocytosis)|GO:1990306(RSP5-BUL ubiquitin ligase complex) complex portal:CPX-2921(complex-primary)|pubmed:25998383(see-also)|intenz:CPX-2921(identity) Ubiquitin ligase complex. Polyubiquinates plasma membrane transporters and permeases, required for their endocytosis and subsequent degradation in the vacuole. BUL1 binds to the target protein, enabling ubiquitylation by RSP5. Phosphorylation of BUL1 results in binding to 14-3-3 proteins proteins, protecting the permeases from down-regulation. Appears to be redundant with the RSP5-BUL2 ubiquitin ligase complex (CPX-2923). - - - - - - - psi-mi:"MI:0469"(IntAct) P39940(0)|P48524(0) +CPX-2923 RSP5-BUL2 ubiquitin ligase complex - 559292 P39940(0)|Q03758(0) ECO:0005546(biological system reconstruction evidence based on paralogy evidence used in manual assertion) - GO:0000209(protein polyubiquitination)|GO:0034450(ubiquitin-ubiquitin ligase activity)|GO:0043162(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|GO:2000397(positive regulation of ubiquitin-dependent endocytosis)|GO:1990306(RSP5-BUL ubiquitin ligase complex) complex portal:CPX-2923(complex-primary)|pubmed:25998383(see-also)|complex portal:CPX-2921(inferred-from)|intenz:2.3.2.26(identity) Ubiquitin ligase complex. Polyubiquinates plasma membrane transporters and permeases, required for their endocytosis and subsequent degradation in the vacuole. BUL2 binds to the target protein, enabling ubiquitylation by RSP5. Phosphorylation of BUL2 results in binding to 14-3-3 proteins, protecting the permeases from down-regulation. Appears to be redundant with the BUL1:RSP5 complex (CPX-2921). - - - - - - - psi-mi:"MI:0469"(IntAct) P39940(0)|Q03758(0) +CPX-2935 RAD6-UBR2 ubiquitin ligase complex RAD6-UBR2 complex|UBC2-UBR2 complex|RAD6/UBC2-UBR2 complex|UBC2-UBR2 ubiquitin ligase complex|RAD6/UBC2-UBR2 ubiquitin ligase complex 559292 P06104(0)|Q07963(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-9103652 GO:1990305(RAD6-UBR2 ubiquitin ligase complex)|GO:0071596(ubiquitin-dependent protein catabolic process via the N-end rule pathway)|GO:0016567(protein ubiquitination)|GO:0004842(ubiquitin-protein transferase activity) complex portal:CPX-2935(complex-primary)|intenz:2.3.2.27(identity)|pubmed:15504724(see-also)|intenz:2.3.2.23(identity) Ubiquitin ligase complex. May act in a quality control pathway for proteins synthesized on cytosolic ribosomes. UBR2 is a paralog of UBR1 (P19812) but lacks the conserved sequence motifs required for N-end rule degradation. - - - - - - - psi-mi:"MI:0469"(IntAct) P06104(0)|Q07963(0) +CPX-2937 MUB1-RAD6-UBR2 ubiquitin ligase complex MUB1-UBC2-UBR2 ubiquitin ligase complex|MUB1-RAD6/UBC2-UBR2 ubiquitin ligase complex|MUB1-RAD6-UBR2 complex|MUB1-UBC2-UBR2 complex|MUB1-RAD6/UBC2-UBR2 complex 559292 P06104(0)|Q03162(0)|Q07963(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-9117501 GO:1990304(MUB1-RAD6-UBR2 ubiquitin ligase complex)|GO:0004842(ubiquitin-protein transferase activity)|GO:0016567(protein ubiquitination)|GO:0071596(ubiquitin-dependent protein catabolic process via the N-end rule pathway) complex portal:CPX-2937(complex-primary)|intenz:2.3.2.23(identity) Ubiquitin ligase complex. Ubiquitylates, and targets for destruction, the RPN4 (Q03465) transcription factor, which upregulates the proteasome genes. The binding of MUB1 may position the RPN4 ubiquitylation site proximal to the Ub∼RAD6 thioester and allowing the transfer of Ubiquitin from RAD6 to RPN4. MUB1 is a short-lived protein and is ubiquitinated by the UBR2-RAD6 ubiquitin conjugating enzyme (CPX-2935). - - - - - - - psi-mi:"MI:0469"(IntAct) P06104(0)|Q03162(0)|Q07963(0) +CPX-2944 MCM complex MCM2-7 heterohexamer|MCM2-7 complex|Minichromosome maintenance (Mcm) 2-7 559292 P24279(1)|P29469(1)|P29496(1)|P30665(1)|P38132(1)|P53091(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-9551191 GO:0042555(MCM complex)|GO:0003697(single-stranded DNA binding)|GO:0003678(DNA helicase activity)|GO:0030174(regulation of DNA-dependent DNA replication initiation) complex portal:CPX-2944(complex-primary)|intenz:3.6.4.12(identity)|rhea:RHEA:13065(identity)|pubmed:15108800(see-also)|pubmed:15928711(see-also)|emdb:EMD-5857(identity) Essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells, associates with the origins of DNA replication to form part of the pre-replicative complex. Activation of the MCM complex at origins by cyclin-dependent kinases and the CDC7 protein kinase (P06243) leads to initiation of DNA synthesis. MCM2-7 complexes unwind the double stranded DNA at the origins, recruit DNA polymerases and initiate DNA synthesis. Two single hexameric complexes are loaded onto double-stranded origin DNA to form a double hexameric ing-shaped, toroidal complex which uses ATP binding and hydrolysis to engage DNA within its central channel.. The MCM2-MCM5 interaction appears to be the gate that promotes the opening of the MCM2–7 complex. The isolated N-terminal domain of each subunit drives assembly into a head-to-head double hexamer, Forms ATPase active sites at clefts between dimer interfaces, with one subunit contributing the P loop (a series of loops connecting adjacent parallel beta-strands), while the adjoining subunit contributes the lid, positioned C terminal to the P-loop domain. The P loop contains motifs involved in binding ATP (Walker A box) and orienting the nucleophilic water molecule (Walker B box), while the lid domain contains arginine finger motifs that contact the gamma-phosphate of ATP but only dimers of 7:3 and 4:7 appear to be active. Two single hexameric complexes are loaded onto double-stranded origin DNA to form a double hexameric ing-shaped, toroidal complex which uses ATP binding and hydrolysis to engage DNA within its central channel.. The MCM2-MCM5 interaction appears to be the gate that promotes the opening of the MCM2–7 complex. The isolated N-terminal domain of each subunit drives assembly into a head-to-head double hexamer, Forms ATPase active sites at clefts between dimer interfaces, with one subunit contributing the P loop (a series of loops connecting adjacent parallel beta-strands), while the adjoining subunit contributes the lid, positioned C terminal to the P-loop domain. The P loop contains motifs involved in binding ATP (Walker A box) and orienting the nucleophilic water molecule (Walker B box), while the lid domain contains arginine finger motifs that contact the gamma-phosphate of ATP but only dimers of 7:3 and 4:7 appear to be active. Two single hexameric complexes are loaded onto double-stranded origin DNA to form a double hexameric ing-shaped, toroidal complex which uses ATP binding and hydrolysis to engage DNA within its central channel.. The MCM2-MCM5 interaction appears to be the gate that promotes the opening of the MCM2–7 complex. The isolated N-terminal domain of each subunit drives assembly into a head-to-head double hexamer, Forms ATPase active sites at clefts between dimer interfaces, with one subunit contributing the P loop (a series of loops connecting adjacent parallel beta-strands), while the adjoining subunit contributes the lid, positioned C terminal to the P-loop domain. The P loop contains motifs involved in binding ATP (Walker A box) and orienting the nucleophilic water molecule (Walker B box), while the lid domain contains arginine finger motifs that contact the gamma-phosphate of ATP but only dimers of 7:3 and 4:7 appear to be active. Heterohexamer - - - - - psi-mi:"MI:0469"(IntAct) P24279(1)|P29469(1)|P29496(1)|P30665(1)|P38132(1)|P53091(1) +CPX-2946 CDC48-NPL4-UFD1 AAA ATPase complex Ufd1-Npl4-Cdc48/p97 (UNC) complex|UNC complex|CDC48(UFD1/NPL4) complex|Cdc48-Ufd1-Npl4 complex|Cdc48p-Npl4p-Ufd1p AAA ATPase complex 559292 P25694(6)|P33755(1)|P53044(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-10044130 GO:0034098(VCP-NPL4-UFD1 AAA ATPase complex)|GO:0043130(ubiquitin binding)|GO:0030433(ubiquitin-dependent ERAD pathway)|GO:0071712(ER-associated misfolded protein catabolic process)|GO:0005524(ATP binding)|GO:0016887(ATPase activity) complex portal:CPX-2946(complex-primary)|pubmed:32668237(see-also)|pubmed:31249135(see-also)|intenz:3.6.4.6(identity)|rhea:RHEA:13065(identity)|wwpdb:6oaa(identity)|wwpdb:6oa9(identity)|emdb:EMD-0666(identity)|emdb:EMD-0665(identity)|pubmed:11733065(see-also)|pubmed:23028185(see-also) Recruited by the integral membrane protein UBX2 (Q04228) and interacts with ubiquitin ligase complexes involved in the endoplasmic reticulum-associated degradation (ERAD) pathway. Binds and appears to disassemble ubiquitylated protein complexes so may function as a segregase. The CDC48 adenosine triphosphatase (ATPase) forms a hexameric,double-ringed assembly with the N-terminal all on the same side of the double-ring. This pulls polypeptides through its central pore. Substrates initially bind through the attached Lys-48 polyubiquitin chain to UFD1/NPL4 and then moves through the pore of the ATPase rings and are unfolded. Heterooctamer - - - - - psi-mi:"MI:0469"(IntAct) P25694(6)|P33755(1)|P53044(1) +CPX-2948 CUE1-UBC7 ubiquitin-conjugating enzyme complex CUE1-UBC7 ubiquitin-conjugating enzyme (E2) complex|UBC7/CUE1 complex 559292 P38428(1)|Q02159(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-9206997 GO:1990389(CUE1-UBC7 ubiquitin-conjugating enzyme complex)|GO:0004842(ubiquitin-protein transferase activity)|GO:0005524(ATP binding)|GO:0043130(ubiquitin binding)|GO:0030433(ubiquitin-dependent ERAD pathway) complex portal:CPX-2948(complex-primary)|wwpdb:4jqu(identity)|intenz:6.3.2.19(identity) Component of the endoplasmic reticulum-associated protein degradation (ERAD) pathway. UBC7 is a ubiquitin-conjugating enzyme (E2) that functions with endoplasmic reticulum resident ubiquitin ligases (E3s) only if bound to the ER surface by CUE1. UBC7 may also be activated by CUE1. - Heterodimer - - - - - psi-mi:"MI:0469"(IntAct) P38428(1)|Q02159(1) +CPX-2950 TIM9-TIM10-TIM12 mitochondrial intermembrane space protein transporter complex TIM9-TIM10-TIM12 complex 559292 O74700(0)|P32830(0)|P87108(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0042719(mitochondrial intermembrane space protein transporter complex)|GO:0005739(mitochondrion) complex portal:CPX-2950(complex-primary) Facilitates transport of hydrophobic precursors of a distinct subgroup of inner membrane proteins through the aqueous intermembrane space as they exit the TOM40 channel complex (CPX-474) in the outer membrane. Functions as a chaperone to maintain the hydrophobic membrane proteins in an import competent state and escort substrates to the TIM22 insertion complex (CPX-1629), which mediates protein insertion into the membrane. - - - - - - - psi-mi:"MI:0469"(IntAct) O74700(0)|P32830(0)|P87108(0) +CPX-3028 1,3-beta-D-glucan synthase complex, FKS3-RHO1 variant - 559292 P06780(0)|Q04952(0) ECO:0005546(biological system reconstruction evidence based on paralogy evidence used in manual assertion) - GO:0006075((1->3)-beta-D-glucan biosynthetic process)|GO:0000148(1,3-beta-D-glucan synthase complex)|GO:0030476(ascospore wall assembly)|GO:0003843(1,3-beta-D-glucan synthase activity)|GO:0016021(integral component of membrane) complex portal:CPX-3028(complex-primary)|rhea:RHEA:21476(identity)|pubmed:17158736(see-also)|pubmed:8602515(see-also)|complex portal:CPX-1812(inferred-from)|intenz:2.4.1.34(identity) Synthesizes 1,3-beta-glucan, a major structural component of the yeast cell wall and of the yeast spore wall. FKS3 variant is responsible for normal spore wall assembly. - - - - - - - psi-mi:"MI:0469"(IntAct) P06780(0)|Q04952(0) +CPX-3034 Acetolactate synthase complex AHAS complex|ALS complex|Acetohydroxy-acid synthase complex 559292 CHEBI:16238(2)|CHEBI:18420(2)|CHEBI:9532(2)|P07342(2)|P25605(2) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-9301798 GO:0005948(acetolactate synthase complex)|GO:0003984(acetolactate synthase activity)|GO:0009082(branched-chain amino acid biosynthetic process)|GO:0005739(mitochondrion) complex portal:CPX-3034(complex-primary)|pubmed:16699828(see-also)|intenz:2.2.1.6(identity) Catalyzes the first step that is common to the biosynthesis of branched-chain amino acids. The reaction involves the irreversible decarboxylation of pyruvate to a bound hydroxyethyl group that then condenses with either a second pyruvate molecule to form 2-acetolactate as the first step in the biosynthesis of valine and leucine. or with 2-ketobutyrate to form 2-aceto-2-hydroxybutyrate as the initial step in the biosynthesis of isoleucine. Allosterically inhibited by binding of valine to the regulatory subunit - this inhibition can be overcome by Mg-ATP (CHEBI:30617). The role of FAD in this complex is unclear. Heterotetramer - - - - - psi-mi:"MI:0469"(IntAct) P07342(2)|P25605(2) +CPX-3036 PMT1-PMT2 dolichyl-phosphate-mannose-protein mannosyltransferase complex - 559292 P31382(1)|P33775(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-457850 GO:1900101(regulation of endoplasmic reticulum unfolded protein response)|GO:0035269(protein O-linked mannosylation)|GO:0009272(fungal-type cell wall biogenesis)|GO:0097582(dolichyl-phosphate-mannose-protein mannosyltransferase Pmt1p-Pmt2p dimer complex)|GO:0004169(dolichyl-phosphate-mannose-protein mannosyltransferase activity)|GO:0030176(integral component of endoplasmic reticulum membrane) complex portal:CPX-3036(complex-primary)|wwpdb:6p2r(identity)|wwpdb:6p25(identity)|emdb:EMD-20240(identity)|emdb:EMD-20236(identity)|intenz:2.4.1.109(identity)|pubmed:23434682(see-also) Initiates protein O-mannosylation by catalyzing the transfer of a mannosyl residue from dolichol-phosphate-beta-D-Mannose to Ser and Thr residues of proteins in an alpha-D-mannosidic linkage. Some proteins with moderate Ser/Thr content are O-mannosylated when they are not properly folded. In the endoplasmic reticulum this removes them from folding cycles by reducing engagement with the KAR2 chaperone (P164740). O-mannosyl glycans are important for the stability, localization and/or function of various secretory and membrane proteins and hence cell wall integrity. Acts on both soluble and membrane proteins. Endoplasmic reticulum membrane glycoproteins comprising seven transmembrane spanning domains. An Asp-Glu motif in the hydrophilic loop between transmembrane domain 1 and 2 is required for dimerization. Heterodimer - - - - - psi-mi:"MI:0469"(IntAct) P31382(1)|P33775(1) +CPX-3037 PMT1-PMT3 dolichyl-phosphate-mannose-protein mannosyltransferase complex - 559292 P33775(1)|P47190(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-457843 GO:0030176(integral component of endoplasmic reticulum membrane)|GO:0004169(dolichyl-phosphate-mannose-protein mannosyltransferase activity)|GO:0035269(protein O-linked mannosylation)|GO:0097583(dolichyl-phosphate-mannose-protein mannosyltransferase Pmt1p-Pmt3p dimer complex)|GO:0009272(fungal-type cell wall biogenesis)|GO:1900101(regulation of endoplasmic reticulum unfolded protein response) complex portal:CPX-3037(complex-primary)|intenz:2.4.1.109(identity)|pubmed:23434682(see-also) Initiates protein O-mannosylation by catalyzing the transfer of a mannosyl residue from dolichol-phosphate-beta-D-Mannose to Ser and Thr residues of proteins in an alpha-D-mannosidic linkage. Some proteins with moderate Ser/Thr content are O-mannosylated when they are not properly folded. In the endoplasmic reticulum this removes them from folding cycles by reducing engagement with the KAR2 chaperone (P164740). O-mannosyl glycans are important for the stability, localization and/or function of various secretory and membrane proteins and hence cell wall integrity. Acts on both soluble and membrane proteins. Endoplasmic reticulum membrane glycoproteins comprising seven transmembrane spanning domains. An Asp-Glu motif in the hydrophilic loop between transmembrane domain 1 and 2 is required for dimerization. Heterodimer - - - - - psi-mi:"MI:0469"(IntAct) P33775(1)|P47190(1) +CPX-3038 PMT5-PMT2 dolichyl-phosphate-mannose-protein mannosyltransferase complex - 559292 P31382(1)|P52867(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-9301970 GO:0097584(dolichyl-phosphate-mannose-protein mannosyltransferase Pmt5p-Pmt2p dimer complex)|GO:0004169(dolichyl-phosphate-mannose-protein mannosyltransferase activity)|GO:0009272(fungal-type cell wall biogenesis)|GO:0035269(protein O-linked mannosylation)|GO:1900101(regulation of endoplasmic reticulum unfolded protein response)|GO:0030176(integral component of endoplasmic reticulum membrane) complex portal:CPX-3038(complex-primary)|intenz:2.4.1.109(identity)|pubmed:23434682(see-also) Initiates protein O-mannosylation by catalyzing the transfer of a mannosyl residue from dolichol-phosphate-beta-D-Mannose to Ser and Thr residues of proteins in an alpha-D-mannosidic linkage. Some proteins with moderate Ser/Thr content are O-mannosylated when they are not properly folded. In the endoplasmic reticulum this removes them from folding cycles by reducing engagement with the KAR2 chaperone (P164740). O-mannosyl glycans are important for the stability, localization and/or function of various secretory and membrane proteins and hence cell wall integrity. Acts on both soluble and membrane proteins. Endoplasmic reticulum membrane glycoproteins comprising seven transmembrane spanning domains. An Asp-Glu motif in the hydrophilic loop between transmembrane domain 1 and 2 is required for dimerization. Heterodimer - - - - - psi-mi:"MI:0469"(IntAct) P31382(1)|P52867(1) +CPX-3039 PMT4 dolichyl-phosphate-mannose-protein mannosyltransferase complex PMT4 dolichyl-phosphate-mannose-protein mannosyltransferase homodimer 559292 P46971(2) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-9301977 GO:0097586(dolichyl-phosphate-mannose-protein mannosyltransferase Pmt4p homodimer complex)|GO:0030176(integral component of endoplasmic reticulum membrane)|GO:0009272(fungal-type cell wall biogenesis)|GO:0004169(dolichyl-phosphate-mannose-protein mannosyltransferase activity)|GO:0035269(protein O-linked mannosylation)|GO:1900101(regulation of endoplasmic reticulum unfolded protein response) complex portal:CPX-3039(complex-primary)|pubmed:23434682(see-also)|intenz:2.4.1.109(identity) Initiates protein O-mannosylation by catalyzing the transfer of a mannosyl residue from dolichol-phosphate-beta-D-Mannose to Ser and Thr residues of proteins in an alpha-D-mannosidic linkage. O-mannosyl glycans are important for the stability, localization and/or function of various secretory and membrane proteins and hence cell wall integrity. Acts on membrane-bound proteins. Endoplasmic reticulum membrane glycoproteins comprising seven transmembrane spanning domains. An Asp-Glu motif in the hydrophilic loop between transmembrane domain 1 and 2 is required for dimerization. Homodimer - - - - - psi-mi:"MI:0469"(IntAct) P46971(2) +CPX-3040 PMT5-PMT3 dolichyl-phosphate-mannose-protein mannosyltransferase complex - 559292 P47190(1)|P52867(1) ECO:0005546(biological system reconstruction evidence based on paralogy evidence used in manual assertion) - GO:0004169(dolichyl-phosphate-mannose-protein mannosyltransferase activity)|GO:0009272(fungal-type cell wall biogenesis)|GO:0030176(integral component of endoplasmic reticulum membrane)|GO:1900101(regulation of endoplasmic reticulum unfolded protein response)|GO:0035269(protein O-linked mannosylation)|GO:0097585(dolichyl-phosphate-mannose-protein mannosyltransferase Pmt5p-Pmt3p dimer complex) complex portal:CPX-3036(inferred-from)|complex portal:CPX-3040(complex-primary)|intenz:2.4.1.109(identity)|pubmed:23434682(see-also) Initiates protein O-mannosylation by catalyzing the transfer of a mannosyl residue from dolichol-phosphate-beta-D-Mannose to Ser and Thr residues of proteins in an alpha-D-mannosidic linkage. Some proteins with moderate Ser/Thr content are O-mannosylated when they are not properly folded. In the endoplasmic reticulum this removes them from folding cycles by reducing engagement with the KAR2 chaperone (P164740). O-mannosyl glycans are important for the stability, localization and/or function of various secretory and membrane proteins and hence cell wall integrity. Acts on both soluble and membrane proteins. Endoplasmic reticulum membrane glycoproteins comprising seven transmembrane spanning domains. An Asp-Glu motif in the hydrophilic loop between transmembrane domain 1 and 2 is required for dimerization. Heterodimer - - - - - psi-mi:"MI:0469"(IntAct) P47190(1)|P52867(1) +CPX-3055 Translocon complex Post-translational translocon complex|Post-translocon 559292 P14906(1)|P21825(1)|P32915(1)|P33754(1)|P35179(1)|P39742(1)|P52870(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-9352347 GO:0030867(rough endoplasmic reticulum membrane)|GO:0071256(translocon complex)|GO:0031204(posttranslational protein targeting to membrane, translocation) pubmed:30545845(see-also)|complex portal:CPX-3055(complex-primary)|wwpdb:6n3q(identity)|emdb:EMD-0336(identity)|wwpdb:6nd1(subset)|emdb:EMD-0440(subset) Post-translationally translocates nascent proteins into the endoplasmic reticulum. The complex is composed of the SEC61 translocon complex protein-conducting channel (CPX-1833) and the tetrameric SEC62-63 complex (CPX-3056). The SEC62-63 complex plays a crucial role in targeting of the signal recognition particle-independent protein substrate to the protein-conducting channel and also in the assembly of the post-translocon complex. M.W.= 287 kDa. Structural studies suggest that SEC63 tightly associates with SEC61 through interactions in cytosolic, transmembrane. SEC61 forms an hourglass-shaped pore with a constriction in the middle of the membrane, a plug domain in the luminal or extracellular cavity, and a lateral gate, which opens to the surrounding lipid phase. The binding of the SEC62–SEC63 complex to the SEC61 channel causes wide opening of the lateral gate. Furthermore, SEC63 optimally positions binding sites for cytosolic and luminal chaperones in the complex to enable efficient polypeptide translocation. Heteroheptamer - - - - - psi-mi:"MI:0469"(IntAct) P14906(1)|P21825(1)|P32915(1)|P33754(1)|P35179(1)|P39742(1)|P52870(1) +CPX-3056 SEC62-SEC63 complex Sec62-Sec63-Sec71-Sec72 complex|SEC62/SEC63 complex 559292 P14906(1)|P21825(1)|P33754(1)|P39742(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-9352389 GO:0031204(posttranslational protein targeting to membrane, translocation)|GO:0031207(Sec62/Sec63 complex)|GO:0030867(rough endoplasmic reticulum membrane) complex portal:CPX-3056(complex-primary) Required for post-translational translocation of nascent proteins into the endoplasmic reticulum. Plays a crucial role in targeting of the signal recognition particle-independent protein substrate to the protein-conducting channel and also in the assembly of the post-translocon complex (CPX-3055). - Heterotetramer - - - - - psi-mi:"MI:0469"(IntAct) P14906(1)|P21825(1)|P33754(1)|P39742(1) +CPX-3069 CDC48-NPL4-VMS1 AAA ATPase complex Vms1–Npl4–Cdc48/p97|Cdc48p-Npl4p-Ufd1p AAA ATPase complex|CDC48(VMS1/NPL4) complex|Cdc48-Vms1-Npl4 complex 559292 P25694(0)|P33755(0)|Q04311(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0036266(Cdc48p-Npl4p-Vms1p AAA ATPase complex)|GO:0043130(ubiquitin binding)|GO:0005524(ATP binding)|GO:0006515(protein quality control for misfolded or incompletely synthesized proteins)|GO:0016887(ATPase activity)|GO:0072671(mitochondria-associated ubiquitin-dependent protein catabolic process) complex portal:CPX-3069(complex-primary)|pubmed:21070972(see-also) Required for the destruction of damaged, misfolded and ubiquitinated proteins in the mitochondrion. Under conditions of mitochondrial stress, VMS1 recruits CDC48 and NPL4 and extracts ubiquitinated proteins for proteasomal degradation. May also play a role in endoplasmic reticulum-associated protein degradation (ERAD). - - - - - - - psi-mi:"MI:0469"(IntAct) P25694(0)|P33755(0)|Q04311(0) +CPX-3070 HRD1 ubiquitin ligase complex Hrd1p ubiquitin ligase complex|Ubiquitin ligase ERAD-L complex 559292 P38307(0)|Q03714(0)|Q04228(0)|Q05787(2)|Q08109(2)|Q99220(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-981951 GO:0000836(Hrd1p ubiquitin ligase complex)|GO:0004842(ubiquitin-protein transferase activity)|GO:0030433(ubiquitin-dependent ERAD pathway) complex portal:CPX-3070(complex-primary)|wwpdb:5V6P(subset)|pubmed:23028185(see-also)|intenz:6.3.2(identity) Transmembrane E3 ubiquitin ligase complex involved in the endoplasmic reticulum-associated degradation (ERAD) pathway, directing misfolded proteins to proteasomal degradation. Required for ERAD-L, -M subpathways which degrade proteins with misfolded luminal or transmembrane domains, respectively. The HRD1 core complex acts together with the E2 ubiquitin conjugating enzymes Cue1-Ubc7 (CPX-2948) and UBC1 (P21734) and also the Cdc48p-Npl4p-Ufd1p AAA ATPase complex (CPX-2946). Usa1 promotes Hrd1 oligomerization as well as its stability, which are required for retrotranslocation and also serves as an adaptor that recruits Der1 which is required for ERAD of both misfolded lumenal and membrane substrates. Hrd3 is required to stabilize Hrd1 because in its absence Hrd1 is rapidly degraded via a Usa1-dependent mechanism. In addition, together with Der1, Hrd3 may facilitate the delivery of substrates to Hrd1 for subsequent retrotranslocation. - - - - - - psi-mi:"MI:0469"(IntAct) P38307(0)|Q03714(0)|Q04228(0)|Q05787(2)|Q08109(2)|Q99220(0) +CPX-3074 Doa10 ubiquitin ligase complex Doa10p ubiquitin ligase complex 559292 P40318(0)|Q04228(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-1008451 GO:0000837(Doa10p ubiquitin ligase complex)|GO:0004842(ubiquitin-protein transferase activity)|GO:0071712(ER-associated misfolded protein catabolic process)|GO:0071712(ER-associated misfolded protein catabolic process) complex portal:CPX-3074(complex-primary)|intenz:2.3.2.27(identity) Transmembrane E3 ubiquitin ligase complex involved in the endoplasmic reticulum-associated degradation (ERAD) pathway, directing misfolded proteins to proteasomal degradation. Required for ERAD-C subpathway which degrades proteins with misfolded cytoplasmic domains. The Doa10 core complex acts together with the E2 ubiquitin conjugating enzymes Ubc6 (P33296) and Cue1-Ubc7 (CPX-2948) and also the Cdc48p-Npl4p-Ufd1p AAA ATPase complex (CPX-2946). - - - - - - - psi-mi:"MI:0469"(IntAct) P40318(0)|Q04228(0) +CPX-3078 Ric1-Rgp1 guanyl-nucleotide exchange factor complex - 559292 P16664(0)|P40395(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-2256636 GO:0034066(RIC1-RGP1 guanyl-nucleotide exchange factor complex)|GO:0005085(guanyl-nucleotide exchange factor activity)|GO:0005794(Golgi apparatus)|GO:0043087(regulation of GTPase activity)|GO:0042147(retrograde transport, endosome to Golgi) complex portal:CPX-3078(complex-primary)|pubmed:10990452(see-also) Guanine nucleotide exchange factor (GEF) that activates YPT6 (Q99260), by exchanging bound GDP for free GTP. YPT6 is a Rab GTPase which mediates the fusion of vesicles from endosomes at the Golgi apparatus and, once activated, recruits the GARP tethering complex (CPX-1718). - - - - - - - psi-mi:"MI:0469"(IntAct) P16664(0)|P40395(0) +CPX-3087 Shu complex - 559292 P38751(1)|P38957(1)|P40465(1)|Q12318(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-7948406 GO:0097196(Shu complex)|GO:0003690(double-stranded DNA binding)|GO:0042275(error-free postreplication DNA repair)|GO:1903112(positive regulation of single-strand break repair via homologous recombination) complex portal:CPX-3087(complex-primary)|pubmed:19496932(see-also)|pubmed:22749910(see-also)|pubmed:24339919(see-also) Role in the early stages of the homologous recombination DNA damage repair process. Recruits the Rad55-Rad57 complex (CPX-3139) and the homologous recombination machinery to the sites of single-stranded DNA gaps left by replication-blocking lesions to complete error-free DNA-damage tolerance. The Shu complex takes the shape of a boomerang with DNA filaments probably attaching to the bottom of the concave. Heterotetramer - - - - - psi-mi:"MI:0471"(MINT) P38751(1)|P38957(1)|P40465(1)|Q12318(1) +CPX-3088 PAS complex PtdIns(3,5)P2 regulatory complex|PI(3,5)P2 regulatory complex 559292 P34756(0)|P42837(0)|P43601(0)|P53950(0)|Q06708(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0000285(1-phosphatidylinositol-3-phosphate 5-kinase activity)|GO:0005524(ATP binding)|GO:0010511(regulation of phosphatidylinositol biosynthetic process)|GO:0043813(phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity)|GO:0070772(PAS complex)|GO:1903100(1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process) complex portal:CPX-3088(complex-primary)|rhea:RHEA:32955(identity)|rhea:RHEA:13609(identity)|pubmed:24323921(see-also)|intenz:2.7.1.150(identity)|intenz:3.1.3(identity) Role in the synthesis and turnover of the low abundance, signaling lipid phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2; CHEBI:16851). PtIns(3,2)P2 has been implicated in processes such as vacuole morphology, homeostasis, membrane scission, acidification and transport vesicle formation. The complex contains both the Fab1 lipid kinase and Fig4 lipid phosphatase. Fig4 may also act as an activator of the Fab1 kinase. The complex also contains both an activator (Vac7) and an inhibitor (Atg18) of Fab1. A conformation change in the complex, in response to stress, could facilitate the rapid flux in PtdIns(3,5)P2 levels that occurs in response to various biological stimuli. - - - - - - psi-mi:"MI:0469"(IntAct) P34756(0)|P42837(0)|P43601(0)|P53950(0)|Q06708(0) +CPX-3139 RAD55-RAD57 complex Rhp55-Rhp57 complex 559292 P25301(1)|P38953(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-1150302 GO:0006302(double-strand break repair)|GO:0042275(error-free postreplication DNA repair)|GO:1903112(positive regulation of single-strand break repair via homologous recombination)|GO:0003697(single-stranded DNA binding)|GO:0033062(Rhp55-Rhp57 complex) complex portal:CPX-3139(complex-primary)|pubmed:34573372(see-also)|pubmed:24339919(see-also) Role in the early stages of the homologous recombination DNA damage repair process. Recruited by the Shu complex (CPX-3087) to the sites of single-stranded DNA gaps left by replication-blocking lesions to complete error-free DNA-damage tolerance. Counteracts the anti-recombination activity of the SRS2 helicase (P12954) by associating with the RAD51 (P25454)-ssDNA filament, rendering it more stable than a nucleoprotein filament containing RAD51 alone. stimulates RAD51 filament assembly onto RPA-coated single-stranded DNA. The RAD51/RAD55-AD57 co-filament resists disruption by the SRS2 anti-recombinase by blocking SRS2 translocation. The complex is also involved in double-strand break repair. RAD55-RAD57 exhibits a weak ATPase activity. - - - - - - psi-mi:"MI:0486"(UniProt) P25301(1)|P38953(1) +CPX-3146 Mitochondrial DNA-directed RNA polymerase complex mitochondrial RNA polymerase|MTF1-RPOM complex 559292 P13433(1)|P14908(1) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0001065(mitochondrial single subunit type RNA polymerase activity)|GO:0006390(mitochondrial transcription)|GO:0005739(mitochondrion)|GO:0034245(mitochondrial DNA-directed RNA polymerase complex) complex portal:CPX-3146(complex-primary)|intenz:2.7.7.6(identity)|pubmed:22353467(see-also)|pubmed:7929382(see-also) Mitochondrial RNA polymerase resides in the mitochondrion and is responsible for transcription of all genes on the mitochondrial genome, both protein- and RNA-coding. Binding of the polymerase complex to the promoter consensus sequence 5-prime-(- 8)ATATAAGTA(+ 1) bends and opens promoter DNA. The ability to initiate transcription at mitochondrial promoters is conferred by the regulatory subunit Mtf1p. The transcriptional activity of mitochondrial RNA polymerase is repressed by the high ATP levels generated during growth on glucose, and activated at low ATP levels during growth on non-fermentable carbon sources. Composed of the polymerase subunit Rpo41 and the transcription factor Mtf1. Heterodimer - - - - - psi-mi:"-"(Saccharomyces Genome Database) P13433(1)|P14908(1) +CPX-3155 NuA4 histone acetyltransferase complex - 559292 CHEBI:29105(0)|P38806(0)|P38811(0)|P39995(0)|P43572(0)|P47128(0)|P53201(0)|P53911(0)|P53930(0)|P60010(0)|P80428(0)|Q06337(0)|Q08649(0)|Q12432(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-9637956 GO:0035267(NuA4 histone acetyltransferase complex)|GO:0004402(histone acetyltransferase activity)|GO:0016573(histone acetylation)|GO:0006351(transcription, DNA-templated)|GO:0005634(nucleus) complex portal:CPX-3155(complex-primary)|pubmed:29559617(see-also)|emdb:6815(subset)|emdb:6816(subset)|wwpdb:5y81(subset)|intenz:2.3.1.48(identity)|pubmed:24843044(see-also)|pubmed:21984211(see-also)|pubmed:15196461(see-also) Essential gene regulatory acetyltransferase with ATPase, DNA helicase and structural DNA binding activities. NuA4 histone acetyltransferase (HAT) complex is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, histone H2B to form H2BK16ac, histone H2A to form H2AK4ac and H2AK7ac, and histone variant H2A.Z to form H2A.ZK14ac. Acetylation of histone H4 is essential for DNA double-strand break repair through homologous recombination. Involved in cell cycle progression. The structure of the NuA4 HAT complex comprises two large globular domains joined by multiple connections. One of these domains is mostly formed by TRA1. The EAF7 subunit bridges EAF5 with EAF3, a H3K36me3‐binding chromodomain protein, and this EAF5/7/3 trimer is anchored to NuA4 through EAF5. TRA1 serves as a scaffold for multiprotein assemblies or as a platform for recruitment of different regulatory factors to chromatin40. Although TRA1 lacks kinase activity, it adopts a kinase-active conformation in the NuA4 complex. The EafAF1 SANT domain tightly binds to TRA1 LBE and FATC domains, which serve as scaffold for NuA4 complex assembly. The actin/ARP4 module mainly interacts with EAF1. - - - - - - psi-mi:"MI:0471"(MINT) P38806(0)|P38811(0)|P39995(0)|P43572(0)|P47128(0)|P53201(0)|P53911(0)|P53930(0)|P60010(0)|P80428(0)|Q06337(0)|Q08649(0)|Q12432(0) +CPX-3158 SPOTS complex Serine Palmitoyltransferase Orm1/2, Tsc3, and Sac1 complex 559292 P25045(0)|P32368(0)|P40970(0)|P53224(0)|Q06144(0)|Q3E790(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-15838944 GO:0035339(SPOTS complex)|GO:0090156(cellular sphingolipid homeostasis)|GO:0004758(serine C-palmitoyltransferase activity) pubmed:23737533(see-also)|complex portal:CPX-3158(complex-primary)|pubmed:20182505(see-also)|intenz:2.3.1.50(identity) Serine C-palmitoyltransferase (SPT) catalyzes the first committed step in the biosynthesis of sphingolipids: condensation of serine with palmitoyl-CoA to form 3-ketosphinganine. The catalytic activity depends on LCB1 and LCB2, and is stimulated several-fold by TSC3. The remaining components are believed to play regulatory roles. Mature sphingolipids are an essential component of the plasma membrane. Moreover, several intermediates in sphingolipid metabolism are important signaling molecules involved in control of growth and stress response. Tight regulation of this rate-limiting step in sphingolipid synthesis is therefore critical for lipid homeostasis, membrane biogenesis, protein quality control and trafficking through the secretory pathway. Regulation of sphingolipid synthesis is mediated by phosphorylation of ORM1 and ORM2 as well as by up-regulation of ORM2 protein levels. Sphingolipid depletion activates the TORC2 complex (CPX-1717), which triggers ORM1 and ORM2 phosphorylation by the protein kinase YPK1 (P12688). Inhibition of the nutrient-sensitive TORC1 complex (CPX-1715 /CPX-1716) triggers phosphorylation of ORM proteins by the protein kinase NPR1 (P22211). Increased phosphorylation of ORM proteins reduces their inhibitory activity resulting in stimulation of SPOTS and increased sphingolipid synthesis. In addition, the presence of the phosphoinositide phosphatase SAC1 (P32368) in the SPOTS complex appears to link sphingolipid synthesis to phosphoinositide signaling that controls ER functions and ER-to-Golgi traffic. Thus, the SPOTS complex may be responsible for coordinating sphingolipid homeostasis with a variety of processes that control cell growth and response to nutrients. The presence of closely related gene products LCB1/2 and ORM1/2 suggest several variants of this complex may exist. - myriocin (CHEBI:582124) - - - - psi-mi:"-"(Saccharomyces Genome Database) P25045(0)|P32368(0)|P40970(0)|P53224(0)|Q06144(0)|Q3E790(0) +CPX-3159 Slx1-Slx4 complex SLX1-SLX4 structure-specific DNA endonuclease complex 559292 CHEBI:60240(0)|P38324(0)|Q12098(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-1567756 GO:0000228(nuclear chromosome)|GO:0033557(Slx1-Slx4 complex)|GO:0017108(5'-flap endonuclease activity)|GO:1902681(regulation of replication fork arrest at rDNA repeats) complex portal:CPX-3159(complex-primary)|pubmed:16267268(see-also)|pubmed:12832395(see-also)|intenz:3.1.22(identity) A structure-specific DNA endonuclease that is involved in DNA recombination and repair. It is involved in rDNA copy number regulation. Appears to act at the termination of rDNA replication cleaves stalled replication forks. - - - - - - - psi-mi:"-"(Saccharomyces Genome Database) P38324(0)|Q12098(0) +CPX-3163 Sulfite reductase complex (NADPH) hydrogen sulfide:NADP+ oxidoreductase|NADPH-sulfite reductase|sulphite reductase complex (NADPH)|YSiR 559292 CHEBI:28599(2)|CHEBI:57692(2)|CHEBI:58210(2)|CHEBI:64607(2)|P39692(2)|P47169(2) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0009337(sulfite reductase complex (NADPH))|GO:0000097(sulfur amino acid biosynthetic process)|GO:0000103(sulfate assimilation)|GO:0004783(sulfite reductase (NADPH) activity)|GO:0005737(cytoplasm) complex portal:CPX-3163(complex-primary)|rhea:RHEA:13801(identity)|pubmed:6758853(see-also)|pubmed:1479340(see-also)|pubmed:6751400(see-also)|intenz:1.8.1.2(identity) Sulfite reductase is a flavoprotein complex that catalyzes the reduction of sulfite to sulfide in the cysteine and methionine biosynthesis pathway. The activity is also required for sulfate assimilation. Strokes radius is 80 A by gel filtration and the molecular weight is estimated to be 604,000. The Km values for sulfite and NADPH is 17 microM and 10 microM, respectively. Enzyme contains two FAD, two FMN and two hemes per molecule. Heterotetramer - - - - - psi-mi:"-"(Saccharomyces Genome Database) P39692(2)|P47169(2) +CPX-3172 EGO complex - 559292 P38247(1)|P53290(0)|Q00582(0)|Q02205(1)|Q3E830(1) ECO:0000353(physical interaction evidence used in manual assertion) wwpdb:6JWP GO:0005525(GTP binding)|GO:0003924(GTPase activity)|GO:0071986(Ragulator complex)|GO:0032008(positive regulation of TOR signaling)|GO:0000329(fungal-type vacuole membrane)|GO:0016237(lysosomal microautophagy) pubmed:26206314(see-also)|complex portal:CPX-3172(complex-primary)|wwpdb:6JWP(identity)|wwpdb:3R7W(subset)|pubmed:23242467(see-also)|pubmed:23123112(see-also)|pubmed:15989961(see-also)|wwpdb:4xpm(subset) The EGO complex is localized to the vacuolar membranes and activates vacuolar membrane associated TORC1 in the presence of preferred nitrogen sources. It thereby has an important role in regulating cell growth and autophagy by relaying amino acid signals. Specifically, its subunit GTR1 becomes activated to a GTP-bound form in a downstream response to nutrient signals, causing EGO to interact with and activate TORC1. EGO is required for recovery from rapamycin-induced growth arrest and positively regulates microautophagy. The EGO complex is composed of 5 subunits. MEH1 (Q02205) is N-myristoylated, which is believed to tether it to the vacuolar membrane. Localization of SLM4 (P38247) to the vacuolar membrane and it’s binding to MEH1 is facilitated by EGO2 (Q3E830). The formation of an intact complex is required for binding the heterodimer GTR1-GTR2 to SLM4, thus docking the Gtr1-Gtr2 GTPases to MEH1 at the vacuolar membrane. GTP-bound GTR1 (Q00582) and GDP-bound GTR2 (P53290) are required for activation of TORC1. - - - - - - psi-mi:"-"(Saccharomyces Genome Database) P38247(1)|P53290(0)|Q00582(0)|Q02205(1)|Q3E830(1) +CPX-3179 Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex - 559292 P32828(1)|P40072(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-1567748 GO:0033768(SUMO-targeted ubiquitin ligase complex)|GO:0005634(nucleus)|GO:0004842(ubiquitin-protein transferase activity)|GO:0003690(double-stranded DNA binding) complex portal:CPX-3179(complex-primary)|pubmed:18032921(see-also)|pubmed:17020915(see-also)|pubmed:17728242(see-also)|pubmed:24018209(see-also)|intenz:6.3.2.19(identity) The Slx5-Slx8 complex is a heterodimeric ubiquitin ligase (E3) that recognizes sumoylated proteins and causes the transfer of ubiquitin from an E2 to its target, attaching polyubiquitin chains to it. The complex has DNA-binding activity and is involved in various cellular processes, including targeting poly-sumoylated proteins for degradation; DNA damage repair and genome stability. The complex is localized to the nucleus and has been implicated in protein quality control of nuclear proteins. - Heterodimer - - - - - psi-mi:"-"(Saccharomyces Genome Database) P32828(1)|P40072(1) +CPX-3180 Mitochondrial degradosome complex mtEXO complex 559292 P32580(1)|P39112(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-9694943 GO:0045025(mitochondrial degradosome)|GO:0008859(exoribonuclease II activity)|GO:0003724(RNA helicase activity)|GO:0003723(RNA binding)|GO:0000957(mitochondrial RNA catabolic process) complex portal:CPX-3180(complex-primary)|pubmed:12426313(see-also)|pubmed:17658549(see-also)|intenz:3.6.4.13(identity)|intenz:3.1.13.1(identity) The mitochondrial degradosome complex is essential for mitochondrial biogenesis. The degradosome, which has both RNA helicase and exoribonuclease activity, co-purifies with proteins from both mitochondrial large and small ribosomal subunits, suggesting that it associates with intact ribosomes. Helicase activity of the degradosome is more efficient with substrates with 3-prime overhangs, and requires the presence of Dss1p. Unprocessed rRNA and mRNA accumulate in cells lacking degradosome activity, however, tRNA maturation is unaffected, indicating that this complex is not directly involved in RNA processing. Instead, the degradosome complex is likely part of the mitochondrial RNA surveillance system, which degrades aberrant and unprocessed RNAs. The complex MW is 160kDa. RNA helicase activity essential for exoribonuclease activity. The degradosome exoribonuclease activity has a Km of 0.9 +/- 0.2 uM. Heterodimer - - - - - psi-mi:"-"(Saccharomyces Genome Database) P32580(1)|P39112(1) +CPX-3184 EAF5-7-3 nucleosome disassembly/reassembly complex Nucleosome dissasembly/reassembly complex 559292 P39995(0)|P53911(0)|Q12432(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-9639515 GO:0032968(positive regulation of transcription elongation from RNA polymerase II promoter)|GO:0006337(nucleosome disassembly)|GO:0005634(nucleus)|GO:1990453(nucleosome disassembly/reassembly complex)|GO:0006335(DNA replication-dependent chromatin assembly) complex portal:CPX-3184(complex-primary)|pubmed:24843044(see-also) Plays a role in co-transcriptional RNA processing and maturation by associating with the coding region of transcriptionally active genes and affecting RNA polymerase II processivity. Promote the disruption, and subsequent reassembly, of nucleosomes. Also exists as a component of the NuA4 histone acetyltransferase complex (CPX-3155) which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The Eaf7 subunit bridges Eaf5 with Eaf3, a H3K36me3‐binding chromodomain protein, and this Eaf5/7/3 complex is anchored to NuA4 complex (CPX-3155) through Eaf5. - - - - - - psi-mi:"MI:0471"(MINT) P39995(0)|P53911(0)|Q12432(0) +CPX-3185 Piccolo NuA4 histone acetyltransferase complex piccolo HAT|picNuA4 559292 P38806(0)|P43572(0)|Q08649(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0000786(nucleosome)|GO:0016573(histone acetylation)|GO:0032777(Piccolo NuA4 histone acetyltransferase complex)|GO:0004402(histone acetyltransferase activity)|GO:0031491(nucleosome binding) complex portal:CPX-3185(complex-primary)|intenz:2.3.1.48(identity)|pubmed:24843044(see-also)|pubmed:12782659(see-also)|pubmed:15196461(see-also) Histone acetyltransferase complex which is involved in transcriptional activation of selected genes, principally by acetylation of nucleosomal histone H4 and H2A. Strongly prefers chromatin over free histones as substrate. Also acts as the catalytic core of the 1.3-MDa NuA4 histone acetyltransferase complex (CPX-3155). Epl1 conserved N-terminal domain bridges Esa1 and Yng2 together, stimulating Esa1 catalytic activity and enabling acetylation of chromatin substrates. - - - - - - psi-mi:"MI:0471"(MINT) P38806(0)|P43572(0)|Q08649(0) +CPX-3188 Polarisome - 559292 P23201(0)|P40091(0)|P41697(0)|P41832(0)|P48566(0)|Q12317(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0000133(polarisome)|GO:0006903(vesicle targeting)|GO:0030010(establishment of cell polarity)|GO:0030950(establishment or maintenance of actin cytoskeleton polarity) complex portal:CPX-3188(complex-primary)|pubmed:22701052(see-also)|pubmed:16166638(see-also) Controls thepolarized (unidimensional) cell growth in yeast and other fungi. Required for tip growth and acts as a central hub for coordinating exocytosis with actin cable formation. One of the targets of polarisome is the Rab GTPase SEC4, which associates with secretory vesicles and stimulates their fusion with the exocytic sites at the plasma membrane. Thus, the primary function of polarisome appears to be guiding polarized transport and secretion along actin cables and bringing secretory vesicles to the sites of polarized growth. SPA2 serves as the polarisome scaffold. The other components include formin BNI1, which nucleates the formation of linear actin filaments, an actin monomer–binding protein BUD6, which acts as nucleation-promoting factor, a coiled-coil protein PEA2, required for localization of the complex at sites of polarized growth, and two redundant Rab GTPase-activating proteins, MSB3 and MSB4. - - - - - - psi-mi:"-"(Saccharomyces Genome Database) P23201(0)|P40091(0)|P41697(0)|P41832(0)|P48566(0)|Q12317(0) +CPX-3196 ERMES complex ER-mitochondria encounter structure|MMM1 complex|Mdm10/Mdm12/Mmm1 complex|mitochore 559292 P18409(0)|P39722(0)|P41800(0)|P53083(0)|Q92328(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0032865(ERMES complex)|GO:1990456(mitochondrion-endoplasmic reticulum membrane tethering)|GO:0030674(protein binding, bridging)|GO:0055091(phospholipid homeostasis)|GO:0007005(mitochondrion organization)|GO:0098799(outer mitochondrial membrane protein complex) complex portal:CPX-3196(complex-primary)|pubmed:19556461(see-also)|pubmed:22435828(see-also)|pubmed:23682313(see-also)|pubmed:21945531(see-also)|pubmed:21825164(see-also)|pubmed:22409400(see-also) The ERMES complex serves as a physical connection between the endoplasmic reticulum (ER) and the mitochondrion. The complex, or simply the physical connection provided by the complex, may facilitate transfer of lipids, calcium ions, or other metabolites between the organelles. Mitochondrial nucleoids are located near ERMES, and the complex is required for accurate segregation of the mitochondrial genome. Mutations is any of the complex subunit genes confer aberrant mitochondrial morphology and inheritance. The stoichiometry of the complex is not known, but it exists in the cell in one to five foci, each containing many units of the complex. These foci are often found next to mitochondrial DNA nucleoids. MDM12, MDM34, and MMM1 contain SMP (synaptotagmin-like, mitochondrial and lipid-binding protein) domains, which are suggested to be involved in lipid binding. GEM1 is a member of the Miro family of rho-like GTPases and regulates its size. - - - - - - psi-mi:"-"(Saccharomyces Genome Database) P18409(0)|P39722(0)|P41800(0)|P53083(0)|Q92328(0) +CPX-3207 Mitochondrial pyruvate dehydrogenase complex PDH|pyruvate dehydrogenase complex (lipoamide) 559292 CHEBI:16238(1)|CHEBI:58937(1)|P09624(12)|P12695(60)|P16387(24)|P16451(12)|P32473(24) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0005967(mitochondrial pyruvate dehydrogenase complex)|GO:0004148(dihydrolipoyl dehydrogenase activity)|GO:0004739(pyruvate dehydrogenase (acetyl-transferring) activity)|GO:0004742(dihydrolipoyllysine-residue acetyltransferase activity)|GO:0006086(acetyl-CoA biosynthetic process from pyruvate)|GO:0030976(thiamine pyrophosphate binding)|GO:0005739(mitochondrion) complex portal:CPX-3207(complex-primary)|pubmed:9038189(see-also)|pubmed:18180296(see-also)|pubmed:9123965(see-also)|pubmed:12756305(see-also)|intenz:2.3.1.12(identity)|intenz:1.2.4.1(identity)|intenz:1.8.1.4(identity) Mitochondrial matrix enzyme that converts pyruvate to acetyl-CoA and CO2. This provides a metabolic connection between glycolysis, whose end product is pyruvate, and the tricarboxylic acid cycle, which starts with acetyl-CoA. Pyruvate dehydrogenase (PDH) activity is negatively regulated via phosphorylation of its PDA1 subunit. The protein kinases PKP1 (P40530) and PKP2 (P53170) phosphorylate PDA1, and the protein phosphatases PTC5 (Q12511) and PTC6 (P25646) mediate its dephosphorylation. Pyruvate dehydrogenase consists of five subunits that are assembled into a huge heteromultimer of 8-9 megadaltons. The core is comprised of 60 copies of LAT1 (also known as E2; dihydrolipoamide acyltransferase) that form a pentagonal dodecahedron. Twelve copies of LDD1 (also known as E3; dihydrolipoamide dehydrogenase) are attached to the LAT1 core via the binding protein PDX1. A variable number of PDA1 and PDB1 (also known as E1 alpha and E1 beta, respectively) subunits bind as heterotetramers to the LAT1 core. In the reaction mediated by the PDH complex, pyruvate becomes covalently linked to the thiamine diphosphate (TPP) cofactor of E1 (PDA1 and PDB1), creating 2-alpha-hydroxy-ethyl-TPP. The alpha-hydroxy group of 2-alpha-hydroxy-ethyl-TPP is subsequently oxidized, creating an acetyl group that becomes bound to the dihydrolipoyllysine group of E2 (LAT1). LAT1 transfers this acetyl group to CoA to generate acetyl-CoA. - - - - - - psi-mi:"-"(Saccharomyces Genome Database) P09624(12)|P12695(60)|P16387(24)|P16451(12)|P32473(24) +CPX-3211 MIS complex Mum2, Ime4, Slz1 complex 559292 P38236(0)|P40167(0)|P41833(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0080009(mRNA methylation)|GO:2000221(negative regulation of pseudohyphal growth)|GO:0036396(RNA N6-methyladenosine methyltransferase complex)|GO:0001734(mRNA (N6-adenosine)-methyltransferase activity) intenz:2.1.1.62(identity)|complex portal:CPX-3211(complex-primary)|pubmed:22685417(see-also)|pubmed:24269006(see-also) The MIS complex is a methyltransferase which methylates adenosine at the N6 position to form N6-methyladenosine. mRNA methylation in Saccharomyces cerevisiae occurs only during meiosis. During meiosis, complete mRNA methylation requires MIS complex localization to the nucleolus in a Slz1-dependent manner. NDT80 also regulates Mum2 and Ime4 nucleolar localization during meiosis. Methylation of mRNA by this complex suppresses pseudohyphal development. - - - - - - - psi-mi:"-"(Saccharomyces Genome Database) P38236(0)|P40167(0)|P41833(0) +CPX-3212 Mitotic checkpoint complex, MAD1-MAD2-BUB1-BUB3 subcomplex Mad2p-Mad1p-Bub1p-Bub3p 559292 P26449(1)|P40957(1)|P40958(1)|P41695(1) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0000776(kinetochore)|GO:0007094(mitotic spindle assembly checkpoint) pubmed:24402315(see-also)|complex portal:CPX-3212(complex-primary)|pubmed:23174302(see-also)|pubmed:10837255(see-also) This complex forms during mitosis, as a result of the activation of the spindle checkpoint. BUB3 and BUB1 are associated through the cell cycle, however, the addition of MAD1 is cell cycle dependent. The formation of a stable complex requires the functions of MAD2, BUB3, and MPS1. In addition, a highly conserved Arg-Leu-Lys motif at 653-655 of MAD1 is required for the formation of a complete complex. - - - - - - - psi-mi:"-"(Saccharomyces Genome Database) P26449(1)|P40957(1)|P40958(1)|P41695(1) +CPX-3215 FACT complex yeast facilitator of chromatin transactions|Pob3-Spt16 complex|yFACT|yeast facilitator of chromatin transcription 559292 P32558(1)|Q04636(1) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0006261(DNA-dependent DNA replication)|GO:0035101(FACT complex)|GO:0034728(nucleosome organization)|GO:1902275(regulation of chromatin organization) complex portal:CPX-3215(complex-primary)|pubmed:21454601(see-also)|pubmed:21807128(see-also)|pubmed:21362547(see-also) A heterodimeric H2A-H2B histone chaperone, that helps reorganize nucleosomes in an ATP independent fashion. It promotes histone removal, deposition and replacement on chromatin. Due to its role in chromatin dynamics, it has a role in many cellular processes related to chromatin: DNA replication, DNA damage and repair, transcription initiation and elongation. The redundant NHP6A/B proteins(P11632/P11633) are involved in FACT function and supply the DNA binding activity, potentially destabilizing nucleosomes to promote formation of alternative chromatin structures in addition to recruiting FACT. FACT is an abundant complex, with about 25,000 heterodimers per haploid yeast cell, or roughly one complex per three nucleosomes. - - - - - - psi-mi:"-"(Saccharomyces Genome Database) P32558(1)|Q04636(1) +CPX-3226 Core mediator complex - 559292 P19263(0)|P19659(0)|P25046(0)|P32259(0)|P32569(0)|P32570(0)|P32585(0)|P33308(0)|P34162(0)|P38304(0)|P38633(0)|P38782(0)|P40356(0)|P47822(0)|P53114(0)|Q06213(0)|Q08278(0)|Q12124(0)|Q12321(0)|Q12343(0)|Q99278(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-9694458 GO:0070847(core mediator complex)|GO:0016251(RNA polymerase II general transcription initiation factor activity)|GO:0051123(RNA polymerase II transcriptional preinitiation complex assembly)|GO:0003713(transcription coactivator activity)|GO:0060261(positive regulation of transcription initiation from RNA polymerase II promoter)|GO:0005634(nucleus)|GO:0032968(positive regulation of transcription elongation from RNA polymerase II promoter) complex portal:CPX-3226(complex-primary)|wwpdb:1YKE(subset)|wwpdb:1ykh(subset)|wwpdb:3FBI(subset)|wwpdb:3FBN(subset)|wwpdb:2hzm(subset)|wwpdb:2hzs(subset)|wwpdb:3j1o(subset)|emdb:5407(subset)|wwpdb:3rj1(subset)|wwpdb:4gwp(subset)|emdb:2634(identity)|pubmed:24550107(see-also) Plays an essential role in gene expression regulation by acting as a bridge between DNA-binding transcription factors and the RNA polymerase II (RNAPII) transcription machinery, serving as a central scaffold within the pre-initiation complex. The Mediator complex is also targeted by sequence-specific, DNA-binding transcription factors and appears to regulate RNAPII at both the initiation and elongation stages of transcription. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and unfolds to an extended conformation and partially surrounds RNAPII specifically interacting with the unphosphorylated form of its C-terminal domain. The Mediator complex dissociates from the RNA polymerase II holoenzyme and stays at the promoter when transcriptional elongation begins. Reversibly associates with the CKM complex (CPX-1853). Mediator lacking the CKM complex has a stimulatory effect on basal transcription. In contrast, Mediator containing the sub-complex represses basal transcription. Molecular weight = >1 MDa. Organized into three sub-modules, termed Head, Middle and Tail which form self-contained segments of the Mediator structure connected by relatively small interfaces. The Mediator head module contains MED6, MED8, MED11, SRB4/MED17, SRB5/MED18, SRB2/MED20 and SRB6/MED22, the middle module contains MED1, MED4,MED7, CSE2/MED9, NUT2/MED10, ROX3/MED19, SRB7/MED21 and SOH1/MED31, and the tail module contains MED2, PGD1/MED3, NUT1/MED5, RGR1/MED14, GAL11/MED15 and SIN4/MED16. Interaction with RNAPII requires large conformational rearrangements made possible by changes at the module interfaces. - - - - - - psi-mi:"MI:0469"(IntAct) P19263(0)|P19659(0)|P25046(0)|P32259(0)|P32569(0)|P32570(0)|P32585(0)|P33308(0)|P34162(0)|P38304(0)|P38633(0)|P38782(0)|P40356(0)|P47822(0)|P53114(0)|Q06213(0)|Q08278(0)|Q12124(0)|Q12321(0)|Q12343(0)|Q99278(0) +CPX-3231 SEA complex Seh1-associated complex 559292 P38164(3)|P38742(1)|P39923(1)|P47170(1)|P53011(3)|Q03897(1)|Q04491(1)|Q08281(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-9820948 GO:0035859(Seh1-associated complex)|GO:1903432(regulation of TORC1 signaling)|GO:0000306(extrinsic component of vacuolar membrane) complex portal:CPX-3231(complex-primary)|pubmed:25073740(see-also)|pubmed:21454883(see-also)|pubmed:23974112(see-also) The SEA complex is a vacuole associated complex of eight proteins. One end of the SEA complex is made of the IML1/NPR2/NPR3 trimer (SEACIT), involved in inhibition of TORC1 (CPX-1715, CPX-1716) signaling, while the other end, composed of RTC1/MTC5/SEA4/SEH1/SecEC13 (SEACAT), is involved in the activation of TORC1 signaling. The subcomplexes interact via MTC5. The complex regulates TORC1 signaling and is involved in maintaining vacuolar integrity, regulating autophagy in response to nitrogen starvation. The complex is structurally related to coatamer complexes. GAP activity was demonstrated for the SEACIT component Iml1 and a putative GEF activity was suggested for NPR2 and NPR3. The complex is about 1 MDa as determined by sedimentation. The abundance, based on abundance of its components - is 2-600 per cell. - - - - - - psi-mi:"-"(Saccharomyces Genome Database) P38164(3)|P38742(1)|P39923(1)|P47170(1)|P53011(3)|Q03897(1)|Q04491(1)|Q08281(1) +CPX-3233 GSE complex Gtr1-Gtr2 GTPase complex|Gap1 sorting in the endosomes compex 559292 P34078(0)|P38247(0)|P53290(0)|Q00582(0)|Q02205(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0071986(Ragulator complex)|GO:0005770(late endosome)|GO:0032456(endocytic recycling)|GO:0003924(GTPase activity)|GO:0005525(GTP binding) pubmed:16732272(see-also)|complex portal:CPX-3233(complex-primary)|wwpdb:3r7w(subset)|pubmed:23242467(see-also)|pubmed:23123112(see-also) GTPase complex that stimulates TORC1 in response to amino acid stimulation. The GSE complex was shown to be localized to late endosomes, and to be required for sorting of GAP1 - a general amino acid permease - to the plasma membrane from endosomes. Regulates exit from rapamycin-induced growth arrest. GSE shares common components with the EGO complex (CPX-3172). The GSE complex is composed of 5 subunits. MEH1 (Q02205) is N-myristoylated, and also potentially palmitoylated. that are believed to tether it to endosomal membranes. SLM4 (P38247) has a homodimeric structure that may assist its binding to Meh1 and its binding of the heterodimer Gtr1-Gtr2, thereby serving to dock the Gtr1-Gtr2 GTPases to MEH1 at the membrane. LTR1 (P34078) is attached to the complex via its binding to GTR1. GTP-bound GTR1 (Q00582) and GDP-bound GTR2 (P53290) are required for GAP1 export to the plasma membrane. The size of the complex is 600 kD by gel filtration, which is substantially larger than the sum of MWs of the components. - - - - - - psi-mi:"-"(Saccharomyces Genome Database) P34078(0)|P38247(0)|P53290(0)|Q00582(0)|Q02205(0) +CPX-3234 SCF-Cdc4 ubiquitin ligase complex - 559292 P07834(1)|P14682(1)|P52286(1)|Q08273(1)|Q12018(1) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0000082(G1/S transition of mitotic cell cycle)|GO:0000086(G2/M transition of mitotic cell cycle)|GO:0006511(ubiquitin-dependent protein catabolic process)|GO:0019005(SCF ubiquitin ligase complex)|GO:0061630(ubiquitin protein ligase activity) pubmed:15688063(see-also)|intenz:6.3.2.19(identity)|complex portal:CPX-3234(complex-primary)|pubmed:9346238(see-also)|pubmed:15571813(see-also)|wwpdb:3mks(subset)|wwpdb:1nex(subset) SCF-Cdc4 is a member of the SCF (Skp1-Cullin-F-box) E3 ubiquitin ligase family, in which the F-box protein, Cdc4, forms the substrate recognition subunit. It is required for both G1/S and G2/M cell cycle transitions, when it ubiquitinates and targets to degradation its substrates such as SIC1, FAR1, CLN1/2 and CLB6. The active complex may be a homodimer. - Heteropentamer - - - - - psi-mi:"-"(Saccharomyces Genome Database) P07834(1)|P14682(1)|P52286(1)|Q08273(1)|Q12018(1) +CPX-3238 SUMO activating enzyme complex Aos1-Uba2 E1complex|SUMO E1 activator enzyme complex|SAE complex 559292 P52488(1)|Q06624(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-15837122 GO:0019948(SUMO activating enzyme activity)|GO:0016925(protein sumoylation)|GO:0031510(SUMO activating enzyme complex) pubmed:9312010(see-also)|pubmed:21209884(see-also)|complex portal:CPX-3238(complex-primary) SUMO activating complex provides an E1-like activity that catalyzes the first step in conjugation of Smt3 (SUMO) to proteins (sumoylation). The activated Smt3 is then transferred to the E2-like SUMO conjugating enzyme Ubc9. In subsequent steps, Smt3 is covalently attached to lysine residues on target proteins by one of the E3-like SUMO ligases that include Siz1, Mms21, Cst9, and Nfi1. Attachment of Smt3 alters protein-protein and protein-DNA interactions, as well as subcellular localization of the target proteins, among which are septins, several DNA repair proteins, and cell division regulators, therefore affecting chromosome segregation, cell cycle control, and likely many other regulatory pathways. The native complex isolated from yeast cells elutes at about 128 kDa In the presence of ATP in vitro, the complex forms a covalent adduct between Smt3 and Uba2, likely via a thioester bond between the C‐terminal carboxyl group of Smt3 and the active site Cys177 of Uba2. Heterodimer - - - - - psi-mi:"-"(Saccharomyces Genome Database) P52488(1)|Q06624(1) +CPX-3241 SCF-Grr1 ubiquitin ligase complex - 559292 P14682(1)|P24814(1)|P52286(1)|Q08273(1)|Q12018(1) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0061630(ubiquitin protein ligase activity)|GO:0000082(G1/S transition of mitotic cell cycle)|GO:0010828(positive regulation of glucose transmembrane transport)|GO:0019005(SCF ubiquitin ligase complex)|GO:0006511(ubiquitin-dependent protein catabolic process)|GO:0019222(regulation of metabolic process) pubmed:10213692(see-also)|pubmed:15571813(see-also)|pubmed:15688063(see-also)|intenz:6.3.2.19(identity)|complex portal:CPX-3241(complex-primary) SCF-Grr1 is a member of the SCF (Skp1-Cullin-F-box) E3 ubiquitin ligase family, in which the F-box protein, Grr1, forms the substrate recognition subunit. It is required for the G1/S cell cycle transition, when it ubiquitinates and targets proteins such as CLN1/2 and GIC2 for degradation. It is a central component in glucose-induced signal transduction, regulating the induction of the glucose transporter Hxt1 via degradation of Mth1 when glucose is abundant. Grr1 is also responsible for the ubiquitination and degradation of several metabolic enzymes and proteins involved in glycolysis and amino-acid biosynthesis.The active complex may be a homodimer. - Heteropentamer - - - - - psi-mi:"-"(Saccharomyces Genome Database) P14682(1)|P24814(1)|P52286(1)|Q08273(1)|Q12018(1) +CPX-3242 SCF-Mdm30 ubiquitin ligase complex - 559292 P14682(1)|P52286(1)|Q05930(1)|Q08273(1)|Q12018(1) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0061630(ubiquitin protein ligase activity)|GO:0019005(SCF ubiquitin ligase complex)|GO:0006511(ubiquitin-dependent protein catabolic process)|GO:0008053(mitochondrial fusion) pubmed:15571813(see-also)|pubmed:15688063(see-also)|intenz:6.3.2.19(identity)|pubmed:21502136(see-also)|pubmed:14747994(see-also)|complex portal:CPX-3242(complex-primary) SCF-Mdm30 is a member of the SCF (Skp1-Cullin-F-box) E3 ubiquitin ligase family, in which the F-box protein, Mdm30, forms the substrate recognition subunit. The complex is required for the degradation of Fzo1 and Gal80, and is thereby involved in mitochondrial fusion and regulation of galactose metabolism. The active complex may be a homodimer. - Heteropentamer - - - - - psi-mi:"-"(Saccharomyces Genome Database) P14682(1)|P52286(1)|Q05930(1)|Q08273(1)|Q12018(1) +CPX-3243 SCF-Ufo1 ubiquitin ligase complex - 559292 P14682(1)|P52286(1)|Q04511(1)|Q08273(1)|Q12018(1) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0019005(SCF ubiquitin ligase complex)|GO:0006511(ubiquitin-dependent protein catabolic process)|GO:0061630(ubiquitin protein ligase activity) pubmed:15571813(see-also)|pubmed:15688063(see-also)|intenz:6.3.2.19(identity)|pubmed:14747994(see-also)|pubmed:22815701(see-also)|complex portal:CPX-3243(complex-primary) SCF-Ufo1 is a member of the SCF (Skp1-Cullin-F-box) E3 ubiquitin ligase family, in which the F-box protein, Ufo1, forms the substrate recognition subunit. The complex is required for the degradation of HO and Gal80, thereby involved in mating type switching and regulation of galactose metabolism. The complex may form a homodimer. - Heteropentamer - - - - - psi-mi:"-"(Saccharomyces Genome Database) P14682(1)|P52286(1)|Q04511(1)|Q08273(1)|Q12018(1) +CPX-3244 SCF-Das1 ubiquitin ligase complex - 559292 P14682(1)|P47005(1)|P52286(1)|Q08273(1)|Q12018(1) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0019005(SCF ubiquitin ligase complex)|GO:0006511(ubiquitin-dependent protein catabolic process)|GO:0061630(ubiquitin protein ligase activity)|GO:0000409(regulation of transcription by galactose) complex portal:CPX-3244(complex-primary)|pubmed:15571813(see-also)|pubmed:15688063(see-also)|intenz:6.3.2.19(identity)|pubmed:14747994(see-also)|pubmed:21323640(see-also) SCF-Das1 is a member of the SCF (Skp1-Cullin-F-box) E3 ubiquitin ligase family, in which the F-box protein, Das1, forms the substrate recognition subunit. The complex is required for the degradation of MIG2 and Gal80, thereby involved in regulation of galactose metabolism. The complex may form a homodimer. - Heteropentamer - - - - - psi-mi:"-"(Saccharomyces Genome Database) P14682(1)|P47005(1)|P52286(1)|Q08273(1)|Q12018(1) +CPX-3248 Asi ubiquitin ligase complex Asi1/Asi2/Asi3 complex 559292 P53895(0)|P53983(0)|P54074(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-10096457 GO:0097658(Asi complex)|GO:0004842(ubiquitin-protein transferase activity)|GO:0005637(nuclear inner membrane)|GO:0006511(ubiquitin-dependent protein catabolic process)|GO:0071230(cellular response to amino acid stimulus) pubmed:25253722(see-also)|pubmed:25236469(see-also)|complex portal:CPX-3248(complex-primary)|pubmed:31679820(see-also) The Asi complex resides in the nuclear inner membrane and ubiquitinates proteins to target them for degradation, as part of the endoplasmic reticulum-associated degradation (ERAD) pathway. It targets two types of substrate: misfolded nuclear inner membrane proteins; and proteins that participate in sterol biosynthesis, including ERG11 (lanosterol 14-alpha-demethylase) and NSG1, a regulator of sterol biosynthesis. The Asi complex has an important role in regulation of the response to extracellular amino acids, by mediating degradation of the transcription factor Stp1. Substrates are recognized by direct binding of Asi2 to their transmembrane domains for subsequent ubiquitination by Asi1/Asi3 and membrane extraction - - - - - - psi-mi:"-"(Saccharomyces Genome Database) P53895(0)|P53983(0)|P54074(0) +CPX-3249 SCF-Met30 ubiquitin ligase complex - 559292 P14682(1)|P39014(1)|P52286(1)|Q08273(1)|Q12018(1) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0019005(SCF ubiquitin ligase complex)|GO:0006511(ubiquitin-dependent protein catabolic process)|GO:0007346(regulation of mitotic cell cycle)|GO:0061630(ubiquitin protein ligase activity)|GO:0031335(regulation of sulfur amino acid metabolic process) pubmed:15571813(see-also)|pubmed:15688063(see-also)|intenz:6.3.2.19(identity)|pubmed:9499404(see-also)|pubmed:16895602(see-also)|complex portal:CPX-3249(complex-primary) SCF-Met30 is a member of the SCF (Skp1-Cullin-F-box) E3 ubiquitin ligase family, in which the F-box protein, Met30, forms the substrate recognition subunit. The complex is required for the ubiquitylation of Met4 and Met32. SCF-Met30 coordinates cell cycle progression with biosynthetic pathways of sulfur-containing metabolites, such as methionine, cysteine, and S-adenosylmethionine. The complex may form a homodimer. - Heteropentamer - - - - - psi-mi:"-"(Saccharomyces Genome Database) P14682(1)|P39014(1)|P52286(1)|Q08273(1)|Q12018(1) +CPX-3250 SCF-Dia2 ubiquitin ligase complex - 559292 P14682(1)|P52286(1)|Q08273(1)|Q08496(1)|Q12018(1) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0019005(SCF ubiquitin ligase complex)|GO:0061630(ubiquitin protein ligase activity)|GO:0006511(ubiquitin-dependent protein catabolic process)|GO:0031573(intra-S DNA damage checkpoint)|GO:0030466(chromatin silencing at silent mating-type cassette)|GO:0006348(chromatin silencing at telomere) pubmed:15571813(see-also)|pubmed:15688063(see-also)|intenz:6.3.2.19(identity)|pubmed:14747994(see-also)|complex portal:CPX-3250(complex-primary)|pubmed:22844255(see-also)|pubmed:21701592(see-also)|pubmed:23172854(see-also) SCF-Dia2 is a member of the SCF (Skp1-Cullin-F-box) E3 ubiquitin ligase family, in which the F-box protein, Dia2, forms the substrate recognition subunit. The complex may form a homodimer. SCF-Dia2 is involved in a number of cellular processes: it has been associated with replication stress response and is considered part of the replisome progression complex responsible for fork stability. CSF-Dia2 has also been linked to part of the intra-S phase DNA damage checkpoint. It is also involved in transcriptional silencing at telomeres and mating type loci, as well as regulating transcription by mediating assembly of the RSC complex. It is required for the degradation of Cdc6 in G1. - Heteropentamer - - - - - psi-mi:"-"(Saccharomyces Genome Database) P14682(1)|P52286(1)|Q08273(1)|Q08496(1)|Q12018(1) +CPX-3253 SCF-Ylr352w ubiquitin ligase complex - 559292 P14682(1)|P52286(1)|Q06479(1)|Q08273(1)|Q12018(1) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0019005(SCF ubiquitin ligase complex)|GO:0061630(ubiquitin protein ligase activity)|GO:0006511(ubiquitin-dependent protein catabolic process) complex portal:CPX-3253(complex-primary)|pubmed:15571813(see-also)|pubmed:15688063(see-also)|intenz:6.3.2.19(identity)|pubmed:19882662(see-also)|pubmed:11283612(see-also) SCF-Ylr362w is a member of the SCF (Skp1-Cullin-F-box) E3 ubiquitin ligase family, in which the F-box protein, Ylr352w, forms the substrate recognition subunit. The cellular role of this complex is unknown. The complex may form a homodimer. - Heteropentamer - - - - - psi-mi:"-"(Saccharomyces Genome Database) P14682(1)|P52286(1)|Q06479(1)|Q08273(1)|Q12018(1) +CPX-3254 SCF-Saf1 ubiquitin ligase complex - 559292 P14682(1)|P38352(1)|P52286(1)|Q08273(1)|Q12018(1) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0019005(SCF ubiquitin ligase complex)|GO:0006511(ubiquitin-dependent protein catabolic process)|GO:0061630(ubiquitin protein ligase activity) pubmed:15571813(see-also)|pubmed:15688063(see-also)|intenz:6.3.2.19(identity)|pubmed:19882662(see-also)|complex portal:CPX-3254(complex-primary)|pubmed:16677311(see-also)|pubmed:24389104(see-also) SCF-Saf1 is a member of the SCF (Skp1-Cullin-F-box) E3 ubiquitin ligase family, in which the F-box protein, Saf1, forms the substrate recognition subunit. The complex is required for the ubiquitylation of Aah1 and several vacuolar/lysosomal enzymes. The complex may form a homodimer. - Heteropentamer - - - - - psi-mi:"-"(Saccharomyces Genome Database) P14682(1)|P38352(1)|P52286(1)|Q08273(1)|Q12018(1) +CPX-3255 SCF-Hrt3 ubiquitin ligase complex - 559292 P14682(1)|P52286(1)|Q08273(1)|Q12018(1)|Q12347(1) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0019005(SCF ubiquitin ligase complex)|GO:0006511(ubiquitin-dependent protein catabolic process)|GO:0061630(ubiquitin protein ligase activity)|GO:0071406(cellular response to methylmercury) complex portal:CPX-3255(complex-primary)|pubmed:15571813(see-also)|pubmed:15688063(see-also)|intenz:6.3.2.19(identity)|pubmed:14747994(see-also)|pubmed:17141224(see-also) SCF-Hrt3 is a member of the SCF (Skp1-Cullin-F-box) E3 ubiquitin ligase family, in which the F-box protein, Hrt3, forms the substrate recognition subunit. The complex is involved in the cellular response to methylmercury. The complex may form a homodimer. - Heteropentamer - - - - - psi-mi:"-"(Saccharomyces Genome Database) P14682(1)|P52286(1)|Q08273(1)|Q12018(1)|Q12347(1) +CPX-3265 Ribosome quality control complex RQC complex|Ribosome-bound quality control complex 559292 P25694(6)|P33755(1)|P53044(1)|Q04781(0)|Q05468(0)|Q12532(0) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:1990112(RQC complex)|GO:0061630(ubiquitin protein ligase activity)|GO:1990116(ribosome-associated ubiquitin-dependent protein catabolic process) complex portal:CPX-3265(complex-primary)|pubmed:31950154(see-also)|pubmed:23479637(see-also)|pubmed:23178123(see-also)|pubmed:20835226(see-also)|pubmed:24535822(see-also)|pubmed:24167726(see-also)|pubmed:23479442(see-also)|intenz:2.3.2.27(identity) A 60S ribosomal subunit-associated complex involved in ubiquitin proteasome mediated degradation of polypeptides whose translation is stalled on the ribosome. The abnormal stalled ribosome is recognized and ubiquitinated at one or more specific residues by the E3 ubiquitin ligase HEL2 (Q05580) . Ribosome ubiquitination induces subunit dissociation by the RQT complex. Dissociation of the 40S subunits allows binding of 60S ribosome-nascent chains to RQC2, which recruits the LTN1 E3 ubiquitin ligase. LTN1 ubiquitinates the nascent polypeptide chains, targeting them for degradation. RQC2 attaches C-terminal alanyl/threonyl sequences to stalled polypeptides. The ATPase CDC48 and cofactors UFD1 and NPL4 unfold ubiquitinated polypeptides, then extracts the peptidyl-tRNA from the 60S, thereby recruiting it to the 26S proteasome for degradation. - - - - - - - psi-mi:"-"(Saccharomyces Genome Database) P25694(6)|P33755(1)|P53044(1)|Q04781(0)|Q05468(0)|Q12532(0) +CPX-3279 INAC inner membrane assembly complex Mitochondrial inner membrane assembly complex 559292 P40576(0)|Q02888(0) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-9978375 GO:1990677(mitochondrial inner membrane assembly complex)|GO:0033615(mitochondrial proton-transporting ATP synthase complex assembly)|GO:0031304(intrinsic component of mitochondrial inner membrane) complex portal:CPX-3279(complex-primary)|pubmed:24942160(see-also) Inner membrane assembly complex (INAC) promotes the biogenesis of mitochondrial F1Fo-ATP synthase by facilitating assembly of the peripheral stalk. Loss of INAC function causes dissociation of the F1-domain from the membrane-integral Fo-portion. - - - - - - - psi-mi:"MI:0471"(MINT) P40576(0)|Q02888(0) +CPX-3281 Mitochondrial proton-transporting ATP synthase complex Mitochondrial respiratory chain complex V 559292 P00830(3)|P00854(1)|P00856(1)|P05626(1)|P07251(3)|P09457(1)|P21306(1)|P30902(1)|P38077(1)|P61829(10)|P81449(1)|P81450(1)|P81451(1)|Q06405(1)|Q12165(1)|Q12233(1)|Q12349(1) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0005753(mitochondrial proton-transporting ATP synthase complex)|GO:0046933(proton-transporting ATP synthase activity, rotational mechanism)|GO:0015986(ATP synthesis coupled proton transport)|GO:0005743(mitochondrial inner membrane) wwpdb:2wpd(subset)|wwpdb:2xok(subset)|wwpdb:6CP5(subset)|wwpdb:6CP3(subset)|wwpdb:6CP7(subset)|wwpdb:6CP6(subset)|emdb:EMD-7547(subset)|emdb:EMD-7546(subset)|emdb:EMD-7548(subset)|emdb:EMD-7549(subset)|complex portal:CPX-3281(complex-primary)|rhea:RHEA:57720(identity)|intenz:7.1.2.2(identity)|pubmed:25938092(see-also)|wwpdb:2hld(subset)|wwpdb:3u2f(subset)|pubmed:20610387(see-also)|pubmed:22864911(see-also) Acts to convert the energy of oxidation-reduction reactions of the electron transport chain (respiration) to the phosphorylation of ADP. The synthesis of ATP is coupled to the respiratory chain via the proton potential. The ATP synthase is a molecular motor composed of two separable parts: F1 and F0. The F1 portion contains the catalytic sites for ATP synthesis and protrudes into the mitochondrial matrix. F0 forms a proton turbine that is embedded in the inner membrane and connected to the rotor of F1. The flux of protons flowing down a potential gradient powers the rotation of the rotor driving the synthesis of ATP. Thus, the flow of protons though F0 is coupled to the synthesis of ATP. Multimeric enzyme complex with an overall molecular weight of about 600,000 Da, consisting of an extra-membranous F1 catalytic domain linked by a central stalk to an intrinsic F0 membrane domain. ATP1 and ATP2 subunits are arranged alternately around a coiled coil of two anti-parallel alpha helices in the ATP3 subunit. The catalytic sites are in the ATP2 subunits at the ATP1/2 subunit interface. The proton pore of the ATP synthase consists of a ring of c subunits (OLI1), which rotates, driven by downhill proton diffusion across the membrane. An essential carboxylate side chain in each subunit provides a proton-binding site. Hetero-30-mer - - - - - psi-mi:"-"(Saccharomyces Genome Database) P00830(3)|P00854(1)|P00856(1)|P05626(1)|P07251(3)|P09457(1)|P21306(1)|P30902(1)|P38077(1)|P61829(10)|P81449(1)|P81450(1)|P81451(1)|Q06405(1)|Q12165(1)|Q12233(1)|Q12349(1) +CPX-3284 Nucleolar ribonuclease MRP complex Ribonuclease MRP|NuMRP|RNAse MRP 559292 P28005(0)|P38208(0)|P38291(0)|P38336(0)|P38786(0)|P40993(0)|P41812(0)|P53218(0)|P53833(0)|Q12530(0)|URS000006F31F_559292(0) ECO:0000353(physical interaction evidence used in manual assertion) - GO:0000172(ribonuclease MRP complex)|GO:0003727(single-stranded RNA binding)|GO:0000171(ribonuclease MRP activity)|GO:0000460(maturation of 5.8S rRNA) wwpdb:3iab(subset)|complex portal:CPX-3284(complex-primary)|pubmed:20086051(see-also)|emdb:1928(identity)|pubmed:17881380(see-also)|pubmed:22332141(see-also)|pubmed:20627997(see-also) RNAse MRP is a highly conserved, essential, site-specific endonuclease complex, closely related to RNAse P complex (CPX-1873). Most protein subunits are common between the two complexes, only Snm1 and Rnp1 are unique to MRP, as well as the RNA component NME1. RNAse MRP is involved in rRNA processing in the nucleolus, but during exit from mitosis it also localizes to specialized cytoplasmic P bodies and participates in cleaving CLB2 mRNA. Similar to the RNA component of RNAse P, NME1 may be involved in catalysis, but this has not been shown. Despite its name (Mitochondrial RNA Processing) the nucleolar complex is not involved in processing mitochondrial RNA. Abundance of the complex is estimated to be ~400 copies/cell, about the same as RNAse P. - - - - - - psi-mi:"-"(Saccharomyces Genome Database) P28005(0)|P38208(0)|P38291(0)|P38336(0)|P38786(0)|P40993(0)|P41812(0)|P53218(0)|P53833(0)|Q12530(0) +CPX-3294 PAN deadenylation complex - 559292 P36102(2)|P53010(1) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-16108511 GO:0031251(PAN complex)|GO:0004535(poly(A)-specific ribonuclease activity)|GO:0000289(nuclear-transcribed mRNA poly(A) tail shortening) complex portal:CPX-3294(complex-primary)|pubmed:23337855(see-also)|pubmed:19596809(see-also)|pubmed:8816488(see-also)|pubmed:24880344(see-also)|wwpdb:4xr7(identity)|intenz:3.1.13.4(identity) PAN is a polyA-binding protein dependent polyA-specific 3' exoribonuclease. It is involved in the regulation of polyA-tail length, shortening it from a default length to transcript specific size. The complex is non-essential, but its deletion results in increased polyA-tail length. The size of the complex is 155 kD by gel filtration. - - - - - - psi-mi:"-"(Saccharomyces Genome Database) P36102(2)|P53010(1) +CPX-3297 FUN30 complex - 559292 P31380(2) ECO:0000353(physical interaction evidence used in manual assertion) intact:EBI-9997123 GO:0008094(DNA-dependent ATPase activity)|GO:0005524(ATP binding)|GO:0003678(DNA helicase activity)|GO:0003682(chromatin binding)|GO:0042766(nucleosome mobilization) intenz:3.6.4.12(identity)|complex portal:CPX-3297(complex-primary)|rhea:RHEA:13065(identity)|pubmed:20075079(see-also)|protein ontology:PR:000024937(identity) Important roles in heterochromatin silencing and DNA repair. Remodels chromatin at the 5-prime end of genes by sliding promoter-proximal nucleosomes. Shares homology with an extended family of Snf2-related ATPases. Fun30 is principally purified as a homodimer with a molecular mass of about 250 kDa. Homodimer - - - - - psi-mi:"MI:1352"(pro) P31380(2) +CPX-3298 Telomerase holoenzyme complex - 559292 P17214(1)|Q03096(1)|Q06163(1)|URS0000348061_559292(1) ECO:0005547(biological system reconstruction evidence based on inference from background scientific knowledge used in manual assertion) - GO:0005697(telomerase holoenzyme complex)|GO:0007004(telomere maintenance via telomerase)|GO:0003721(telomerase RNA reverse transcriptase activity)|GO:0003720(telomerase activity)|GO:0000332(template for synthesis of G-rich strand of telomere DNA activity) intenz:2.7.7.49(identity)|pubmed:10898986(see-also)|complex portal:CPX-3298(complex-primary)|rhea:RHEA:22508(identity)|pubmed:22879408(see-also) Telomerase is a ribonucleoprotein complex that is essential for maintenance of telomeres. It is a reverse transcriptase that elongates the single-stranded G-rich 3' protruding ends of chromosomal DNA using TLC1 RNA as a template. Est1 and TLC1 are sufficient for telomerase activity in vitro, but in vivo all 4 subunits are required. Although telomerase activity can be detected throughout the cell cycle, telomeres are only elongated in late S-phase. Telomerase is known to interact with other complexes, including CDC13 complex (via EST1), Yku70/80 complex (CPX-1732) (via TLC1) and Sm heteroheptameric complex (via TLC1). The complex has low abundance, the RNA component has abundance of 30 molecules/cell. - - - - - - psi-mi:"-"(Saccharomyces Genome Database) P17214(1)|Q03096(1)|Q06163(1) diff --git a/data/databases/DBnewGeneAnnotation.tsv b/data/deprecated/databases/DBnewGeneAnnotation.tsv similarity index 100% rename from data/databases/DBnewGeneAnnotation.tsv rename to data/deprecated/databases/DBnewGeneAnnotation.tsv diff --git a/data/databases/FAEgeneNames.tsv b/data/deprecated/databases/FAEgeneNames.tsv similarity index 100% rename from data/databases/FAEgeneNames.tsv rename to data/deprecated/databases/FAEgeneNames.tsv diff --git a/data/databases/TransRxnGeneAnnotation.tsv b/data/deprecated/databases/TransRxnGeneAnnotation.tsv similarity index 100% rename from data/databases/TransRxnGeneAnnotation.tsv rename to data/deprecated/databases/TransRxnGeneAnnotation.tsv diff --git a/data/databases/Yeast7.6MNXMetMappingList.tsv b/data/deprecated/databases/Yeast7.6MNXMetMappingList.tsv similarity index 100% rename from data/databases/Yeast7.6MNXMetMappingList.tsv rename to data/deprecated/databases/Yeast7.6MNXMetMappingList.tsv diff --git a/data/databases/Yeast7.6MNXRxnMappingList.tsv b/data/deprecated/databases/Yeast7.6MNXRxnMappingList.tsv similarity index 100% rename from data/databases/Yeast7.6MNXRxnMappingList.tsv rename to data/deprecated/databases/Yeast7.6MNXRxnMappingList.tsv diff --git a/data/modelCuration/Biolog_newRxnMatrix.tsv b/data/deprecated/modelCuration/Biolog_newRxnMatrix.tsv similarity index 100% rename from data/modelCuration/Biolog_newRxnMatrix.tsv rename to data/deprecated/modelCuration/Biolog_newRxnMatrix.tsv diff --git a/data/modelCuration/Biolog_newRxnMetAnnotation.tsv b/data/deprecated/modelCuration/Biolog_newRxnMetAnnotation.tsv similarity index 100% rename from data/modelCuration/Biolog_newRxnMetAnnotation.tsv rename to data/deprecated/modelCuration/Biolog_newRxnMetAnnotation.tsv diff --git a/data/modelCuration/Biolog_newRxnProp.tsv b/data/deprecated/modelCuration/Biolog_newRxnProp.tsv similarity index 100% rename from data/modelCuration/Biolog_newRxnProp.tsv rename to data/deprecated/modelCuration/Biolog_newRxnProp.tsv diff --git a/data/modelCuration/Biomass_newRxnMatrix.tsv b/data/deprecated/modelCuration/Biomass_newRxnMatrix.tsv similarity index 100% rename from data/modelCuration/Biomass_newRxnMatrix.tsv rename to data/deprecated/modelCuration/Biomass_newRxnMatrix.tsv diff --git a/data/modelCuration/Biomass_newRxnMet.tsv b/data/deprecated/modelCuration/Biomass_newRxnMet.tsv similarity index 100% rename from data/modelCuration/Biomass_newRxnMet.tsv rename to data/deprecated/modelCuration/Biomass_newRxnMet.tsv diff --git a/data/modelCuration/Biomass_newRxnProp.tsv b/data/deprecated/modelCuration/Biomass_newRxnProp.tsv similarity index 100% rename from data/modelCuration/Biomass_newRxnProp.tsv rename to data/deprecated/modelCuration/Biomass_newRxnProp.tsv diff --git a/data/modelCuration/DBnewRxnIDmappinglist.tsv b/data/deprecated/modelCuration/DBnewRxnIDmappinglist.tsv similarity index 100% rename from data/modelCuration/DBnewRxnIDmappinglist.tsv rename to data/deprecated/modelCuration/DBnewRxnIDmappinglist.tsv diff --git a/data/modelCuration/DBnewRxnMetAnnotation.tsv b/data/deprecated/modelCuration/DBnewRxnMetAnnotation.tsv similarity index 100% rename from data/modelCuration/DBnewRxnMetAnnotation.tsv rename to data/deprecated/modelCuration/DBnewRxnMetAnnotation.tsv diff --git a/data/modelCuration/DBnewRxnProp.tsv b/data/deprecated/modelCuration/DBnewRxnProp.tsv similarity index 100% rename from data/modelCuration/DBnewRxnProp.tsv rename to data/deprecated/modelCuration/DBnewRxnProp.tsv diff --git a/data/modelCuration/DBnewrRxnMatrix.tsv b/data/deprecated/modelCuration/DBnewrRxnMatrix.tsv similarity index 100% rename from data/modelCuration/DBnewrRxnMatrix.tsv rename to data/deprecated/modelCuration/DBnewrRxnMatrix.tsv diff --git a/data/modelCuration/FAEnewRxnMatrix.tsv b/data/deprecated/modelCuration/FAEnewRxnMatrix.tsv similarity index 100% rename from data/modelCuration/FAEnewRxnMatrix.tsv rename to data/deprecated/modelCuration/FAEnewRxnMatrix.tsv diff --git a/data/modelCuration/FAEnewRxnMetAnnotation.tsv b/data/deprecated/modelCuration/FAEnewRxnMetAnnotation.tsv similarity index 100% rename from data/modelCuration/FAEnewRxnMetAnnotation.tsv rename to data/deprecated/modelCuration/FAEnewRxnMetAnnotation.tsv diff --git a/data/modelCuration/FAEnewRxnProp.tsv b/data/deprecated/modelCuration/FAEnewRxnProp.tsv similarity index 100% rename from data/modelCuration/FAEnewRxnProp.tsv rename to data/deprecated/modelCuration/FAEnewRxnProp.tsv diff --git a/data/modelCuration/GapfillingnewRxnMatrix.tsv b/data/deprecated/modelCuration/GapfillingnewRxnMatrix.tsv similarity index 100% rename from data/modelCuration/GapfillingnewRxnMatrix.tsv rename to data/deprecated/modelCuration/GapfillingnewRxnMatrix.tsv diff --git a/data/modelCuration/GapfillingnewRxnProp.tsv b/data/deprecated/modelCuration/GapfillingnewRxnProp.tsv similarity index 100% rename from data/modelCuration/GapfillingnewRxnProp.tsv rename to data/deprecated/modelCuration/GapfillingnewRxnProp.tsv diff --git a/data/modelCuration/MetaCyc_deltaG.tsv b/data/deprecated/modelCuration/MetaCyc_deltaG.tsv similarity index 100% rename from data/modelCuration/MetaCyc_deltaG.tsv rename to data/deprecated/modelCuration/MetaCyc_deltaG.tsv diff --git a/data/modelCuration/Metabolomics_newRxnMatrix.tsv b/data/deprecated/modelCuration/Metabolomics_newRxnMatrix.tsv similarity index 100% rename from data/modelCuration/Metabolomics_newRxnMatrix.tsv rename to data/deprecated/modelCuration/Metabolomics_newRxnMatrix.tsv diff --git a/data/modelCuration/Metabolomics_newRxnMetAnnotation.tsv b/data/deprecated/modelCuration/Metabolomics_newRxnMetAnnotation.tsv similarity index 100% rename from data/modelCuration/Metabolomics_newRxnMetAnnotation.tsv rename to data/deprecated/modelCuration/Metabolomics_newRxnMetAnnotation.tsv diff --git a/data/modelCuration/Metabolomics_newRxnProp.tsv b/data/deprecated/modelCuration/Metabolomics_newRxnProp.tsv similarity index 100% rename from data/modelCuration/Metabolomics_newRxnProp.tsv rename to data/deprecated/modelCuration/Metabolomics_newRxnProp.tsv diff --git a/data/modelCuration/Missingmetaboliteformulas.tsv b/data/deprecated/modelCuration/Missingmetaboliteformulas.tsv similarity index 100% rename from data/modelCuration/Missingmetaboliteformulas.tsv rename to data/deprecated/modelCuration/Missingmetaboliteformulas.tsv diff --git a/data/modelCuration/grpContribution_deltaG.tsv b/data/deprecated/modelCuration/grpContribution_deltaG.tsv similarity index 100% rename from data/modelCuration/grpContribution_deltaG.tsv rename to data/deprecated/modelCuration/grpContribution_deltaG.tsv diff --git a/data/modelCuration/iSce926curatedGeneRules.tsv b/data/deprecated/modelCuration/iSce926curatedGeneRules.tsv similarity index 100% rename from data/modelCuration/iSce926curatedGeneRules.tsv rename to data/deprecated/modelCuration/iSce926curatedGeneRules.tsv diff --git a/data/modelCuration/iSce926newGenes.tsv b/data/deprecated/modelCuration/iSce926newGenes.tsv similarity index 100% rename from data/modelCuration/iSce926newGenes.tsv rename to data/deprecated/modelCuration/iSce926newGenes.tsv diff --git a/data/modelCuration/memote_revIdx.tsv b/data/deprecated/modelCuration/memote_revIdx.tsv similarity index 100% rename from data/modelCuration/memote_revIdx.tsv rename to data/deprecated/modelCuration/memote_revIdx.tsv diff --git a/data/modelCuration/metabolite_manual_curation.tsv b/data/deprecated/modelCuration/metabolite_manual_curation.tsv similarity index 100% rename from data/modelCuration/metabolite_manual_curation.tsv rename to data/deprecated/modelCuration/metabolite_manual_curation.tsv diff --git a/data/modelCuration/modMetsandSmatrix.tsv b/data/deprecated/modelCuration/modMetsandSmatrix.tsv similarity index 100% rename from data/modelCuration/modMetsandSmatrix.tsv rename to data/deprecated/modelCuration/modMetsandSmatrix.tsv diff --git a/data/modelCuration/modifyID.tsv b/data/deprecated/modelCuration/modifyID.tsv similarity index 100% rename from data/modelCuration/modifyID.tsv rename to data/deprecated/modelCuration/modifyID.tsv diff --git a/data/modelCuration/rxnDirectionInfo.tsv b/data/deprecated/modelCuration/rxnDirectionInfo.tsv similarity index 100% rename from data/modelCuration/rxnDirectionInfo.tsv rename to data/deprecated/modelCuration/rxnDirectionInfo.tsv diff --git a/data/modelCuration/volatileSulfurCompounds/VoSulGenes.tsv b/data/deprecated/modelCuration/volatileSulfurCompounds/VoSulGenes.tsv similarity index 100% rename from data/modelCuration/volatileSulfurCompounds/VoSulGenes.tsv rename to data/deprecated/modelCuration/volatileSulfurCompounds/VoSulGenes.tsv diff --git a/data/modelCuration/volatileSulfurCompounds/VoSulMets.tsv b/data/deprecated/modelCuration/volatileSulfurCompounds/VoSulMets.tsv similarity index 100% rename from data/modelCuration/volatileSulfurCompounds/VoSulMets.tsv rename to data/deprecated/modelCuration/volatileSulfurCompounds/VoSulMets.tsv diff --git a/data/modelCuration/volatileSulfurCompounds/VoSulRxns.tsv b/data/deprecated/modelCuration/volatileSulfurCompounds/VoSulRxns.tsv similarity index 100% rename from data/modelCuration/volatileSulfurCompounds/VoSulRxns.tsv rename to data/deprecated/modelCuration/volatileSulfurCompounds/VoSulRxns.tsv diff --git a/data/modelCuration/volatileSulfurCompounds/VoSulRxnsCoeffs.tsv b/data/deprecated/modelCuration/volatileSulfurCompounds/VoSulRxnsCoeffs.tsv similarity index 100% rename from data/modelCuration/volatileSulfurCompounds/VoSulRxnsCoeffs.tsv rename to data/deprecated/modelCuration/volatileSulfurCompounds/VoSulRxnsCoeffs.tsv diff --git a/data/modelCuration/README.md b/data/modelCuration/README.md index 96263c18..591ed12f 100644 --- a/data/modelCuration/README.md +++ b/data/modelCuration/README.md @@ -1,3 +1,9 @@ -## Model Curation +## Model curation -Data files used for performing curations to the model. Mostly lists of new rxns, mets or genes added (or fixed) in the model. +Data files used for performing curations to the model. + +Organized in folders that indicate to which model version the changes should be applied. E.g. 'v8_6_0' contains data files to curate model version 8.6.0 (but note that it does not specify the version number of the _new_ model). + +The data files here mainly exist of list with reactions, metabolites etc., and their annotations. + +Data that conceivably could be used repeatedly (so not only to curate one specific model version), might be better kept in ../physiology or ../databases. diff --git a/data/modelCuration/TransRxnNewGPR.tsv b/data/modelCuration/TransRxnNewGPR.tsv deleted file mode 100644 index fa037801..00000000 --- a/data/modelCuration/TransRxnNewGPR.tsv +++ /dev/null @@ -1,102 +0,0 @@ -rxnID new_gpr -r_4468 ( YDR342C or YHR092C ) -r_1735 YBL042C -r_4493 YNL065W -r_4387 ( YJR152W or YKR093W ) -r_4398 ( YJR152W or YKR093W ) -r_4408 ( YJR152W or YKR093W ) -r_4473 ( YJR152W or YKR093W ) -r_4429 ( YJR152W or YKR093W ) -r_4471 ( YJR152W or YKR093W ) -r_4402 ( YJR152W or YKR093W ) -r_2190 YNL065W -r_1707 ( YDR342C or YHR092C ) -r_1717 ( YDL245C or YEL069C or YJR158W or YNR072W ) -r_2041 ( YDR342C or YHR092C ) -r_4395 ( YDL245C or YDR342C or YDR343C or YDR345C or YEL069C or YFL011W or YHR092C or YHR094C or YHR096C or YJL214W or YJL219W or YJR158W or YMR011W or YNR072W or YOL156W ) -r_1719 YHR092C -r_1149 YGL077C -r_1795 YNL065W -r_1990 YJL212C -r_4404 ( YJR152W or YKR093W ) -r_4424 ( YJR152W or YKR093W ) -r_4437 ( YJR152W or YKR093W ) -r_4361 ( YJR152W or YKR093W ) -r_1816 YNL065W -r_2191 YNL065W -r_1877 ( YDR342C or YHR092C ) -r_4469 YKR039W -r_1908 ( YDL245C or YEL069C or YJR158W or YNR072W ) -r_1910 ( YDL245C or YDR342C or YDR343C or YDR345C or YEL069C or YFL011W or YHR092C or YHR094C or YHR096C or YJL214W or YJL219W or YJR158W or YMR011W or YNR072W or YOL156W ) -r_4448 ( YJR152W or YKR093W ) -r_4457 YDR093W -r_2040 YOR306C -r_2105 ( YDL245C or YLL043W ) -r_1882 YOR100C -r_3607 YCR098C -r_1574 YKL120W -r_1642 YPR011C -r_1684 ( YGL077C or YOR161C ) -r_3959 YBR192W -r_3680 YHR002W -r_3960 YBR192W -r_1760 ( YIL013C or YOR011W ) -r_1803 YGL225W -r_2094 ( YLL052C or YPR192W ) -r_3526 ( YLL052C or YPR192W ) -r_3604 ( YLL052C or YLL053C or YPR192W ) -r_1179 ( YJL133W or YKR052C ) -r_1657 YBR147W -r_1658 YDR508C -r_1811 YPR058W -r_1837 YBR147W -r_1919 YBR147W -r_1935 YDR508C -r_1907 YKR039W -r_2045 YDR508C -r_3545 YKR039W -r_2072 YDR508C -r_1771 ( YKL188C and YPL147W ) -r_1772 ( YKL188C and YPL147W ) -r_1976 YOR100C -r_2231 ( YKL188C and YPL147W ) -r_1774 ( YKL188C and YPL147W ) -r_3961 ( YER053C or YJR077C or YLR348C ) -r_2008 YNR013C -r_3605 ( YCR037C or YJL198W or YML123C ) -r_3649 YNR013C -r_3893 YIL048W -r_3813 ( YIL048W or YMR162C ) -r_3897 YIL048W -r_3817 ( YIL048W or YMR162C ) -r_3894 YIL048W -r_3814 ( YIL048W or YMR162C ) -r_3898 YIL048W -r_3818 ( YIL048W or YMR162C ) -r_3895 YIL048W -r_3815 ( YIL048W or YMR162C ) -r_3899 YIL048W -r_3819 ( YIL048W or YMR162C ) -r_3896 YIL048W -r_3816 ( YIL048W or YMR162C ) -r_3900 YIL048W -r_3820 ( YIL048W or YMR162C ) -r_3821 YAL026C -r_3885 YAL026C -r_3825 YAL026C -r_3889 YAL026C -r_3822 YAL026C -r_3886 YAL026C -r_3826 YAL026C -r_3890 YAL026C -r_3823 YAL026C -r_3887 YAL026C -r_3827 YAL026C -r_3891 YAL026C -r_3824 YAL026C -r_3888 YAL026C -r_3828 YAL026C -r_3892 YAL026C -r_3606 YCR098C -r_1236 ( YKL188C and YPL147W ) -r_2107 ( YIL013C or YOR011W ) diff --git a/data/modelCuration/databasenewGPR.tsv b/data/modelCuration/databasenewGPR.tsv deleted file mode 100644 index 50d302e6..00000000 --- a/data/modelCuration/databasenewGPR.tsv +++ /dev/null @@ -1,50 +0,0 @@ -rxnID_yeast_model genes_yeast_model final_GPR -r_0308 YGL184C ( YFR055W or YGL184C ) -r_0148 YDR226W ( YDL166C or YDR226W ) -r_1729 NAN YDL166C -r_1077 YNR012W ( YDR020C or YNR012W ) -r_1078 YNR012W ( YDR020C or YNR012W ) -r_0226 (( Q0080 and Q0085 and Q0130 and YBL099W and YBR039W and YDL004W and YDR298C and YDR322C-A and YDR377W and YJR121W and YKL016C and YLR295C and YML081C-A and YPL078C and YPL271W ) or ( Q0080 and Q0085 and Q0130 and YBL099W and YBR039W and YDL004W and YDR298C and YDR377W and YJR121W and YKL016C and YLR295C and YML081C-A and YPL078C and YPL271W and YPR020W )) (( Q0080 and Q0085 and Q0130 and YBL099W and YBR039W and YDL004W and YDR298C and YDR322C-A and YDR377W and YJR121W and YKL016C and YLR295C and YML081C-A and YPL078C and YPL271W ) or ( Q0080 and Q0085 and Q0130 and YBL099W and YBR039W and YDL004W and YDR298C and YDR377W and YJR121W and YKL016C and YLR295C and YML081C-A and YPL078C and YPL271W and YPR020W ) or ( Q0080 and Q0085 and Q0130 and YBL099W and YBR039W and YDL004W and YDR298C and YDR322C-A and YDR377W and YJR121W and YKL016C and YLR295C and YML081C-A and YPL078C and YPL271W and YJL180C and YLR393W and YNL315C and YOL077W-A and YCL005W-A)) -r_0364 YBR252W ( YJR069C or YBR252W ) -r_0815 YAL012W ( YLL058W or YML082W or YAL012W ) -r_0448 YJL155C ( YLR345W or YJL155C ) -r_0534 ( YCL040W or YFR053C or YGL253W ) ( YLR446W or YCL040W or YFR053C or YGL253W ) -r_0533 ( YFR053C or YGL253W ) ( YLR446W or YFR053C or YGL253W ) -r_0535 ( YFR053C or YGL253W ) ( YLR446W or YFR053C or YGL253W ) -r_0477 YKL104C ( YMR084W or YKL104C ) -r_2116 ( YMR170C or YER073W or YOR374W ) ( YMR110C or YMR170C or YER073W or YOR374W ) -r_0172 ( YMR169C or YMR170C ) ( YMR110C or YMR169C or YMR170C ) -r_0483 ( YBR244W or YCL035C or YDR513W or YIR037W or YKL026C ) ( YNL229C or YBR244W or YCL035C or YDR513W or YIR037W or YKL026C ) -r_2025 NAN YNR027W -r_1185 YBR293W ( YOL092W or YBR293W ) -r_1200 ( YBR293W or YCL069W or YMR088C ) ( YOL092W or YBR293W or YCL069W or YMR088C ) -r_1212 ( YBR293W or YCL069W or YMR088C ) ( YOL092W or YBR293W or YCL069W or YMR088C ) -r_0366 ( YGR254W or YHR174W ) ( YPL281C or YGR254W or YHR174W or YMR323W or YOR393W) -r_1805 NAN ( YBR241C or YGL104C ) -r_0783 YLR328W ( YCL047C or YLR328W ) -r_0530 ( YDR376W and YPL252C ) ( YER141W or (YDR376W and YPL252C) ) -r_1084 YKL035W ( YHL012W or YKL035W ) -r_0475 NAN YFL060C -r_4049 NAN ( YBL035C or YBR278W or YCR014C or YIR008C or YKL045W or YDL102W or YDL164C or YDR121W or YDR419W or YJR006W or YJR043C or YNL102W or YNL262W or YOR330C or YPL167C or YPR175W or YKR002W ) -r_4050 NAN ( YBR154C or YHR143W-A or YIL021W or YKL144C or YKR025W or YFL036W or YDL140C or YDL150W or YDR045C or YDR156W or YDR404C or YGL070C or YJL011C or YJL140W or YJL148W or YJR063W or YNL113W or YNL151C or YNL248C or YNR003C or YOL005C or YOR116C or YOR151C or YOR207C or YOR210W or YOR224C or YOR340C or YOR341W or YPR010C or YPR110C or YPR187W or YPR190C ) -r_0438 (( Q0045 and Q0250 and Q0275 and YDL067C and YEL039C and YGL187C and YGL191W and YHR051W and YIL111W and YLR038C and YLR395C and YMR256C ) or ( Q0045 and Q0250 and Q0275 and YDL067C and YEL039C and YGL187C and YGL191W and YHR051W and YLR038C and YLR395C and YMR256C and YNL052W ) or ( Q0045 and Q0250 and Q0275 and YDL067C and YGL187C and YGL191W and YHR051W and YIL111W and YJR048W and YLR038C and YLR395C and YMR256C ) or ( Q0045 and Q0250 and Q0275 and YDL067C and YGL187C and YGL191W and YHR051W and YJR048W and YLR038C and YLR395C and YMR256C and YNL052W )) (( Q0045 and Q0250 and Q0275 and YDL067C and YEL039C and YGL187C and YGL191W and YHR051W and YIL111W and YLR038C and YLR395C and YMR256C ) or ( Q0045 and Q0250 and Q0275 and YDL067C and YEL039C and YGL187C and YGL191W and YHR051W and YLR038C and YLR395C and YMR256C and YNL052W ) or ( Q0045 and Q0250 and Q0275 and YDL067C and YGL187C and YGL191W and YHR051W and YIL111W and YJR048W and YLR038C and YLR395C and YMR256C ) or ( Q0045 and Q0250 and Q0275 and YDL067C and YGL187C and YGL191W and YHR051W and YJR048W and YLR038C and YLR395C and YMR256C and YNL052W ) or (Q0045 and Q0250 and Q0275 and YDL067C and YHR116W and YDR231C and YGR062C and YJL003W and YPL132W and YLL018C-A)) -r_1166 ( YDL245C or YDL247W or YDR342C or YDR343C or YDR345C or YDR536W or YEL069C or YFL011W or YHR092C or YHR094C or YHR096C or YJL214W or YJL219W or YJR158W or YJR160C or YLR081W or YMR011W or YNR072W or YOL156W ) ( YDL245C or YDL247W or YDR342C or YDR343C or YDR345C or YDR536W or YEL069C or YFL011W or YHR092C or YHR094C or YHR096C or YJL214W or YJL219W or YJR158W or YJR160C or YLR081W or YMR011W or YNR072W or YOL156W or YDR387C ) -r_3264 ( YBR204C or YKR089C or YMR313C or YOR081C ) ( YBR204C or YKR089C or YMR313C or YOR081C or YCR068W ) -r_3297 YMR313C ( YCR068W or YMR313C ) -r_0804 YER005W ( YAL035W or YLL001W or YER005W ) -r_1667 NAN YNL036W -r_0005 ( YGR032W or ( YLR342W and YCR034W )) ( YGR032W or YMR306W or ( YLR342W and YCR034W )) -r_1172 YLL043W ( YFL054C or YLL043W ) -r_1217 YDR105C ( YCL025C or YDR508C or YFL055W or YKR039W or YPL265W or YDR105C ) -r_1258 YLR138W ( YDR456W or YLR138W) -r_1249 YJL129C ( YDR456W or YJL129C ) -r_0193 YPR026W ( YPR026W or YBR001C ) -r_2064 NAN YDL024C -r_0323 YJR159W ( YDL246C or YJR159W ) -r_0199 YMR293C ( YDR242W or YMR293C ) -r_0139 YML022W ( YDR441C or YML022W) -r_0542 YDR234W ( YJL200C or YDR234W ) -r_0893 YKL152C ( YOR283W or YKL152C ) -r_1048 YLR354C ( YGR043C or YLR354C ) -r_1021 (YDR178W and YJL045W and YKL141W and YLL041C) or (YDR178W and YKL141W and YKL148C and YLL041C) (YDR178W and YJL045W and YKL141W and YLL041C) or (YDR178W and YKL141W and YKL148C and YLL041C) or ( YLR164W and YJL045W and YKL141W and YLL041C) -r_0475 YFL060C ( YFL060C or YNL334C ) diff --git a/data/modelCuration/v8_6_0/complexAnnotation.tsv b/data/modelCuration/v8_6_0/complexAnnotation.tsv new file mode 100644 index 00000000..c213c00f --- /dev/null +++ b/data/modelCuration/v8_6_0/complexAnnotation.tsv @@ -0,0 +1,45 @@ +rxnID_yeast_model genes_yeast_model final_GPR complex portal SGD uniprot argument +r_0005 YGR032W or YMR306W or (YLR342W and YCR034W) (YPR165W and YLR342W) or (YPR165W and YGR032W) or (YPR165W and YMR306W) https://www.ebi.ac.uk/complexportal/complex/CPX-1812; https://www.ebi.ac.uk/complexportal/complex/CPX-1813; https://www.ebi.ac.uk/complexportal/complex/CPX-3028 https://www.yeastgenome.org/locus/S000003264; https://www.yeastgenome.org/locus/S000004923 https://www.uniprot.org/uniprot/P40989; https://www.uniprot.org/uniprot/Q04952 YGR032W or YMR306W are subunit. +r_0021 YDR204W and YGL119W and YGR255C and YLR201C and YML110C and YOL096C and YOR125C YDR204W and YGR255C and YLR201C and YML110C and YOL096C and YOR125C https://www.ebi.ac.uk/complexportal/complex/CPX-1155 YGL119W is not a subunit of the complex +r_0022 YDR204W and YGL119W and YGR255C and YLR201C and YML110C and YOL096C and YOR125C YDR204W and YGR255C and YLR201C and YML110C and YOL096C and YOR125C https://www.ebi.ac.uk/complexportal/complex/CPX-1155 YGL119W is not a subunit of the complex +r_0263 (YHL003C and YMR298W) or (YKL008C and YMR298W) YKL008C and YHL003C and YMR298W https://www.ebi.ac.uk/complexportal/complex/CPX-1706 https://www.yeastgenome.org/locus/S000001491; https://www.yeastgenome.org/locus/S000004913 https://www.yeastgenome.org/locus/S000000995 https://www.uniprot.org/uniprot/P28496; https://www.uniprot.org/uniprot/Q03579 https://www.uniprot.org/uniprot/P38703 These three subunits work as a whole +r_0264 (YHL003C and YMR298W) or (YKL008C and YMR298W) YKL008C and YHL003C and YMR298W https://www.ebi.ac.uk/complexportal/complex/CPX-1706 https://www.yeastgenome.org/locus/S000001491; https://www.yeastgenome.org/locus/S000004913 https://www.yeastgenome.org/locus/S000000995 https://www.uniprot.org/uniprot/P28496; https://www.uniprot.org/uniprot/Q03579 https://www.uniprot.org/uniprot/P38703 These three subunits work as a whole +r_0265 (YHL003C and YMR298W) or (YKL008C and YMR298W) YKL008C and YHL003C and YMR298W https://www.ebi.ac.uk/complexportal/complex/CPX-1706 https://www.yeastgenome.org/locus/S000001491; https://www.yeastgenome.org/locus/S000004913 https://www.yeastgenome.org/locus/S000000995 https://www.uniprot.org/uniprot/P28496; https://www.uniprot.org/uniprot/Q03579 https://www.uniprot.org/uniprot/P38703 These three subunits work as a whole +r_0266 (YHL003C and YMR298W) or (YKL008C and YMR298W) YKL008C and YHL003C and YMR298W https://www.ebi.ac.uk/complexportal/complex/CPX-1706 https://www.yeastgenome.org/locus/S000001491; https://www.yeastgenome.org/locus/S000004913 https://www.yeastgenome.org/locus/S000000995 https://www.uniprot.org/uniprot/P28496; https://www.uniprot.org/uniprot/Q03579 https://www.uniprot.org/uniprot/P38703 These three subunits work as a whole +r_0532 YDR204W and YGL119W and YGR255C and YLR201C and YML110C and YOL096C and YOR125C YDR204W and YGR255C and YLR201C and YML110C and YOL096C and YOR125C https://www.ebi.ac.uk/complexportal/complex/CPX-1155 YGL119W is not a subunit of the complex +r_0831 YDR148C and YFL018C and YIL125W (YDR148C and YFL018C and YIL125W and YFR049W) or (YDR148C and YFL018C and YIL125W) https://www.ebi.ac.uk/complexportal/complex/CPX-1293 "YDR148C, YFL018C, YIL125W and YFR049W could also catalyze the reaction" +r_0832 YDR148C and YFL018C and YIL125W (YDR148C and YFL018C and YIL125W and YFR049W) or (YDR148C and YFL018C and YIL125W) https://www.ebi.ac.uk/complexportal/complex/CPX-1293 "YDR148C, YFL018C, YIL125W and YFR049W could also catalyze the reaction" +r_0906 (YKL088W and YKR072C and YOR054C) or (YKL088W and YKR072C) or (YKL088W and YOR054C) or YKL088W YKL088W and YKR072C and YOR054C https://www.ebi.ac.uk/complexportal/complex/CPX-393 https://www.yeastgenome.org/locus/S000001571; https://www.yeastgenome.org/locus/S000001780 https://www.uniprot.org/uniprot/P36076; https://www.uniprot.org/uniprot/P36024 These three subunits work as a whole +r_0943 YDR400W and YLR017W and YLR209C YLR209C https://www.yeastgenome.org/locus/S000004199 https://www.uniprot.org/uniprot/Q05788 YLR209C catalyze the reaction independently +r_0963 YDR204W and YGL119W and YGR255C and YLR201C and YML110C and YOL096C and YOR125C YDR204W and YGR255C and YLR201C and YML110C and YOL096C and YOR125C https://www.ebi.ac.uk/complexportal/complex/CPX-1155 YGL119W is not a subunit of the complex +r_0985 YDR204W and YGL119W and YGR255C and YLR201C and YML110C and YOL096C and YOR125C YDR204W and YGR255C and YLR201C and YML110C and YOL096C and YOR125C https://www.ebi.ac.uk/complexportal/complex/CPX-1155 YGL119W is not a subunit of the complex +r_0992 (YDL040C and YGR147C and YHR013C) or (YDL040C and YGR147C) YHR013C and YDL040C and YOR253W https://www.ebi.ac.uk/complexportal/complex/CPX-783 https://www.yeastgenome.org/locus/S000003379 YGR147C is not a subunit of the complex +r_0993 (YBR058C-A and YDR062W and YMR296C) or (YDR062W and YMR296C) YMR296C and YKL212W and YDR062W and YGR038W and YLR350W and YBR058C-A https://www.ebi.ac.uk/complexportal/complex/CPX-3158 +r_2852 YBR097W and YLR240W (YBR097W and YLR240W) or (YBR097W and YLR240W and YPL120W and YLR360W) or (YBR097W and YLR240W and YBR128C and YPL120W and YLR211C) https://www.ebi.ac.uk/complexportal/complex/CPX-1881; https://www.ebi.ac.uk/complexportal/complex/CPX-1677 Another two complex could also catalyze the reaction +r_2853 YBR097W and YLR240W (YBR097W and YLR240W) or (YBR097W and YLR240W and YPL120W and YLR360W) or (YBR097W and YLR240W and YBR128C and YPL120W and YLR211C) https://www.ebi.ac.uk/complexportal/complex/CPX-1881; https://www.ebi.ac.uk/complexportal/complex/CPX-1677 Another two complex could also catalyze the reaction +r_2854 YBR097W and YLR240W (YBR097W and YLR240W) or (YBR097W and YLR240W and YPL120W and YLR360W) or (YBR097W and YLR240W and YBR128C and YPL120W and YLR211C) https://www.ebi.ac.uk/complexportal/complex/CPX-1881; https://www.ebi.ac.uk/complexportal/complex/CPX-1677 Another two complex could also catalyze the reaction +r_2855 YBR097W and YLR240W (YBR097W and YLR240W) or (YBR097W and YLR240W and YPL120W and YLR360W) or (YBR097W and YLR240W and YBR128C and YPL120W and YLR211C) https://www.ebi.ac.uk/complexportal/complex/CPX-1881; https://www.ebi.ac.uk/complexportal/complex/CPX-1677 Another two complex could also catalyze the reaction +r_2856 YBR097W and YLR240W (YBR097W and YLR240W) or (YBR097W and YLR240W and YPL120W and YLR360W) or (YBR097W and YLR240W and YBR128C and YPL120W and YLR211C) https://www.ebi.ac.uk/complexportal/complex/CPX-1881; https://www.ebi.ac.uk/complexportal/complex/CPX-1677 Another two complex could also catalyze the reaction +r_2857 YBR097W and YLR240W (YBR097W and YLR240W) or (YBR097W and YLR240W and YPL120W and YLR360W) or (YBR097W and YLR240W and YBR128C and YPL120W and YLR211C) https://www.ebi.ac.uk/complexportal/complex/CPX-1881; https://www.ebi.ac.uk/complexportal/complex/CPX-1677 Another two complex could also catalyze the reaction +r_2858 YBR097W and YLR240W (YBR097W and YLR240W) or (YBR097W and YLR240W and YPL120W and YLR360W) or (YBR097W and YLR240W and YBR128C and YPL120W and YLR211C) https://www.ebi.ac.uk/complexportal/complex/CPX-1881; https://www.ebi.ac.uk/complexportal/complex/CPX-1677 Another two complex could also catalyze the reaction +r_2859 YBR097W and YLR240W (YBR097W and YLR240W) or (YBR097W and YLR240W and YPL120W and YLR360W) or (YBR097W and YLR240W and YBR128C and YPL120W and YLR211C) https://www.ebi.ac.uk/complexportal/complex/CPX-1881; https://www.ebi.ac.uk/complexportal/complex/CPX-1677 Another two complex could also catalyze the reaction +r_3216 YLR386W and YNL325C YFR019W and YNL325C and YFR021W and YNL054W and YLR386W https://www.ebi.ac.uk/complexportal/complex/CPX-3088 "YFR019W, YFR021W and YNL054W are also necessary" +r_3217 YLR386W and YNL325C YFR019W and YNL325C and YFR021W and YNL054W and YLR386W https://www.ebi.ac.uk/complexportal/complex/CPX-3088 "YFR019W, YFR021W and YNL054W are also necessary" +r_3218 YLR386W and YNL325C YFR019W and YNL325C and YFR021W and YNL054W and YLR386W https://www.ebi.ac.uk/complexportal/complex/CPX-3088 "YFR019W, YFR021W and YNL054W are also necessary" +r_3219 YLR386W and YNL325C YFR019W and YNL325C and YFR021W and YNL054W and YLR386W https://www.ebi.ac.uk/complexportal/complex/CPX-3088 "YFR019W, YFR021W and YNL054W are also necessary" +r_3220 YLR386W and YNL325C YFR019W and YNL325C and YFR021W and YNL054W and YLR386W https://www.ebi.ac.uk/complexportal/complex/CPX-3088 "YFR019W, YFR021W and YNL054W are also necessary" +r_3221 YLR386W and YNL325C YFR019W and YNL325C and YFR021W and YNL054W and YLR386W https://www.ebi.ac.uk/complexportal/complex/CPX-3088 "YFR019W, YFR021W and YNL054W are also necessary" +r_3222 YLR386W and YNL325C YFR019W and YNL325C and YFR021W and YNL054W and YLR386W https://www.ebi.ac.uk/complexportal/complex/CPX-3088 "YFR019W, YFR021W and YNL054W are also necessary" +r_3223 YLR386W and YNL325C YFR019W and YNL325C and YFR021W and YNL054W and YLR386W https://www.ebi.ac.uk/complexportal/complex/CPX-3088 "YFR019W, YFR021W and YNL054W are also necessary" +r_1085 YBR127C and YDL185W and YEL027W and YEL051W and YGR020C and YHR026W and YHR039C-A and YKL080W and YLR447C and YMR054W and YOR332W and YPL234C and YPR036W (YPR170W-B and YBR127C and YDL185W and YOR332W and YHR026W and YEL027W and YKL080W and YLR447C and YEL051W and YPL234C and YMR054W and YGR020C and YPR036W and YHR039C-A and YGR106C and YCL005W-A) or (YBR127C and YDL185W and YOR332W and YHR026W and YEL027W and YKL080W and YLR447C and YEL051W and YPL234C and YMR054W and YGR020C and YPR036W and YHR039C-A and YGR106C and YCL005W-A) https://www.ebi.ac.uk/complexportal/complex/CPX-1192 +r_1086 YBR127C and YDL185W and YEL027W and YEL051W and YGR020C and YHR026W and YHR039C-A and YKL080W and YLR447C and YOR270C and YOR332W and YPL234C and YPR036W (YBR127C and YDL185W and YEL027W and YEL051W and YGR020C and YHR026W and YHR039C-A and YKL080W and YLR447C and YOR270C and YOR332W and YPL234C and YPR036W and YPR170W-B and YGR106C and YCL005W-A) or (YBR127C and YDL185W and YEL027W and YEL051W and YGR020C and YHR026W and YHR039C-A and YKL080W and YLR447C and YOR270C and YOR332W and YPL234C and YPR036W and YGR106C and YCL005W-A) https://www.ebi.ac.uk/complexportal/complex/CPX-1193 +r_0886 YMR205C or (YGR240C and YMR205C) YGR240C and YMR205C https://www.ebi.ac.uk/complexportal/complex/CPX-554 https://www.yeastgenome.org/locus/S000004818 https://www.uniprot.org/uniprot/P16862 YMR205C is a subunit +r_0887 YMR205C or (YGR240C and YMR205C) YGR240C and YMR205C https://www.ebi.ac.uk/complexportal/complex/CPX-554 https://www.yeastgenome.org/locus/S000004818 https://www.uniprot.org/uniprot/P16862 YMR205C is a subunit +r_2836 YDR373W and YNL267W YDR373W and YNL267W keep the original grRules +r_2837 YDR373W and YNL267W YDR373W and YNL267W keep the original grRules +r_2838 YDR373W and YNL267W YDR373W and YNL267W keep the original grRules +r_2839 YDR373W and YNL267W YDR373W and YNL267W keep the original grRules +r_2840 YDR373W and YNL267W YDR373W and YNL267W keep the original grRules +r_2841 YDR373W and YNL267W YDR373W and YNL267W keep the original grRules +r_2842 YDR373W and YNL267W YDR373W and YNL267W keep the original grRules +r_2843 YDR373W and YNL267W YDR373W and YNL267W keep the original grRules diff --git a/data/modelCuration/v8_6_0/complexAnnotationGenes.tsv b/data/modelCuration/v8_6_0/complexAnnotationGenes.tsv new file mode 100644 index 00000000..29ad2a2e --- /dev/null +++ b/data/modelCuration/v8_6_0/complexAnnotationGenes.tsv @@ -0,0 +1,14 @@ + geneShortName ncbigene refseq uniprot kegg.genes ecogene hprd asap ccds ncbiprotein +YPR165W RHO1 856294 NM_001184262 P06780 sce:YPR165W NP_015491 +YFR049W YMR31 850610 NM_001180014 P19955 sce:YFR049W NP_116707 +YOR253W NAT5 854427 NM_001183672 Q08689 sce:YOR253W 2.3.1.258 NP_014896 +YGR038W ORM1 852926 NM_001181167 P53224 sce:YGR038W NP_011552 +YLR350W ORM2 851064 NM_001182239 Q06144 sce:YLR350W NP_013454 +YBR128C ATG14 852425 NM_001178476 P38270 sce:YBR128C NP_009686 +YLR211C ATG38 850908 NM_001182098 Q05789 sce:YLR211C NP_013312 +YLR360W VPS38 851074 NM_001182249 Q05919 sce:YLR360W NP_013464 +YPL120W VPS30 855983 NM_001183934 Q02948 sce:YPL120W NP_015205 +YFR021W ATG18 850577 NM_001179986 P43601 sce:YFR021W NP_444297 +YNL054W VAC7 855673 NM_001182893 P53950 sce:YNL054W NP_014344 +YGR106C VOA1 852998 NM_001181235 P53262 sce:YGR106C NP_011620 +YPR170W-B 5848745 NM_001184525 P0C5R9 sce:YPR170W-B NP_001106949 diff --git a/data/modelCuration/v8_6_0/newGPRsfromDBs.tsv b/data/modelCuration/v8_6_0/newGPRsfromDBs.tsv new file mode 100644 index 00000000..1a809483 --- /dev/null +++ b/data/modelCuration/v8_6_0/newGPRsfromDBs.tsv @@ -0,0 +1,16 @@ +rxnID_yeast_model genes_yeast_model final_GPR Uniport SGD +r_1614 NAN (YGL101W or YBR242W) https://www.uniprot.org/uniprot/P53144; https://www.uniprot.org/uniprot/P38331 https://www.yeastgenome.org/locus/S000000446; https://www.yeastgenome.org/locus/S000003069 +r_1615 NAN (YGL101W or YBR242W) https://www.uniprot.org/uniprot/P53144; https://www.uniprot.org/uniprot/P38331 https://www.yeastgenome.org/locus/S000000446; https://www.yeastgenome.org/locus/S000003069 +r_1616 NAN (YGL101W or YBR242W) https://www.uniprot.org/uniprot/P53144; https://www.uniprot.org/uniprot/P38331 https://www.yeastgenome.org/locus/S000000446; https://www.yeastgenome.org/locus/S000003069 +r_1617 NAN (YGL101W or YBR242W) https://www.uniprot.org/uniprot/P53144; https://www.uniprot.org/uniprot/P38331 https://www.yeastgenome.org/locus/S000000446; https://www.yeastgenome.org/locus/S000003069 +r_4584 NAN (YOR317W or YER015W or YMR246W or YIL009W) https://www.uniprot.org/uniprot/P30624; https://www.uniprot.org/uniprot/P39518; https://www.uniprot.org/uniprot/P47912; https://www.uniprot.org/uniprot/P39002 https://www.yeastgenome.org/locus/S000005844; https://www.yeastgenome.org/locus/S000000817; https://www.yeastgenome.org/locus/S000004860; https://www.yeastgenome.org/locus/S000001271 +r_4372 NAN YGR247W https://legacy.uniprot.org/uniprot/P53314 https://www.yeastgenome.org/locus/S000003479 +r_4388 NAN YGR247W https://legacy.uniprot.org/uniprot/P53314 https://www.yeastgenome.org/locus/S000003479 +r_4400 NAN (YBR299W or YGR292W) https://legacy.uniprot.org/uniprot/P38158; https://legacy.uniprot.org/uniprot/P53341 https://www.yeastgenome.org/locus/S000000503; https://www.yeastgenome.org/locus/S000003524 +r_4412 NAN YGR247W https://legacy.uniprot.org/uniprot/P53314 https://www.yeastgenome.org/locus/S000003479 +r_4420 NAN (YBR299W or YGR292W) https://legacy.uniprot.org/uniprot/P38158; https://legacy.uniprot.org/uniprot/P53341 https://www.yeastgenome.org/locus/S000000503; https://www.yeastgenome.org/locus/S000003524 +r_4570 NAN (YIL074C or YER081W) https://legacy.uniprot.org/uniprot/P40510; https://legacy.uniprot.org/uniprot/P40054 https://www.yeastgenome.org/locus/S000001336; https://www.yeastgenome.org/locus/S000000883 +r_1703 NAN YKL024C https://legacy.uniprot.org/uniprot/P15700 https://www.yeastgenome.org/locus/S000001507 +r_1704 NAN YKL024C https://legacy.uniprot.org/uniprot/P15700 https://www.yeastgenome.org/locus/S000001507 +r_1736 NAN YDR196C https://legacy.uniprot.org/uniprot/Q03941 https://www.yeastgenome.org/locus/S000002604 +r_2026 NAN YNR027W https://legacy.uniprot.org/uniprot/P53727 https://www.yeastgenome.org/locus/S000005310 diff --git a/data/modelCuration/v8_6_0/newGPRsfromDBsGenes.tsv b/data/modelCuration/v8_6_0/newGPRsfromDBsGenes.tsv new file mode 100644 index 00000000..194666d9 --- /dev/null +++ b/data/modelCuration/v8_6_0/newGPRsfromDBsGenes.tsv @@ -0,0 +1,3 @@ +genes geneShortName ncbigene refseq uniprot kegg.genes ecogene hprd asap ccds ncbiprotein +YBR242W 852544 NM_001178590 P38331 sce:YBR242W NP_009801 +YGL101W YGK1 852777 NM_001180966 P53144 sce:YGL101W NP_011414 diff --git a/data/modelCuration/v8_6_0/transRxnNewGPR.tsv b/data/modelCuration/v8_6_0/transRxnNewGPR.tsv new file mode 100644 index 00000000..b446411b --- /dev/null +++ b/data/modelCuration/v8_6_0/transRxnNewGPR.tsv @@ -0,0 +1,29 @@ +rxnID new_gpr SGD uniport yeastcyc kegg TCDB argument +r_1108 (YER056C or YER060W or YER060W-A) https://www.yeastgenome.org/locus/S000003154 https://www.uniprot.org/uniprot/P17064; https://www.uniprot.org/uniprot/P53099 https://www.uniprot.org/uniprot/Q12119 https://www.uniprot.org/uniprot/P40039 https://biocyc.org/gene?orgid=YEAST&id=G3O-30671 https://www.genome.jp/entry/sce:YGL186C YGL186C is Vitamin transport not adenine +r_1134 (YDL245C or YDR342C or YDR343C or YDR345C or YEL069C or YFL011W or YHR092C or YHR094C or YHR096C or YJL214W or YJL219W or YJR158W or YMR011W or YNR072W or YOL156W) keep the original grRules +r_1135 (YFL011W or YJL219W or YLR081W or YNL318C or YOL156W) https://www.yeastgenome.org/locus/S000002944 https://www.uniprot.org/uniprot/P39932 https://biocyc.org/gene?orgid=YEAST&id=G3O-30046 https://www.genome.jp/entry/sce:YDR536W YDR536W could not transport galactose +r_1139 (YDL245C or YDR342C or YHR094C or YDR343C or YDR345C or YEL069C or YFL011W or YHR096C or YJL214W or YJL219W or YJR158W or YNR072W or YOL156W) https://www.yeastgenome.org/locus/S000001134; https://www.yeastgenome.org/locus/S000005516 https://www.yeastgenome.org/locus/S000001136; https://www.yeastgenome.org/locus/S000001134 https://www.uniprot.org/uniprot/P32467; https://www.uniprot.org/uniprot/P23585 https://biocyc.org/gene?orgid=YEAST&id=G3O-31139 https://www.genome.jp/entry/sce:YHR092C; https://www.genome.jp/entry/sce:YMR011W YHR092C and YMR011W could not transport mannose +r_1183 (YCL025C or YKR039W or YOR348C or YPL265W) https://www.yeastgenome.org/locus/S000000272; yeastgenome.org/locus/S000005380 https://www.yeastgenome.org/locus/S000002453 https://www.uniprot.org/uniprot/P38084; https://www.uniprot.org/uniprot/P41815; https://www.uniprot.org/uniprot/P38967 https://biocyc.org/gene?orgid=YEAST&id=G3O-29037 https://www.genome.jp/entry/sce:YDR046C "YBR068C, YDR046C and YOL020W could not transport alanine" +r_1218 (YCL025C or YDR508C or YKR039W) https://www.yeastgenome.org/locus/S000000273; https://www.yeastgenome.org/locus/S000002453 https://www.uniprot.org/uniprot/P38085; https://www.uniprot.org/uniprot/P41815 https://www.genome.jp/entry/sce:YBR069C YBR069C or YDR046C could not transport threonine +r_1238 YKR039W https://www.yeastgenome.org/locus/S000002453 https://www.uniprot.org/uniprot/P04817 https://www.genome.jp/entry/sce:YEL063C YEL063C could not transport orntithine +r_1805 YBR241C https://www.yeastgenome.org/locus/S000003072 https://www.uniprot.org/uniprot/P53142 https://www.genome.jp/entry/sce:YEL063C "YGL104C involved in protein sorting, not glucose transport" +r_1910 (YDL245C or YDR342C or YDR343C or YDR345C or YEL069C or YFL011W or YHR092C or YHR096C or YJL214W or YJL219W or YJR158W or YNR072W or YOL156W) https://www.yeastgenome.org/locus/S000001136 https://www.uniprot.org/uniprot/P32465; https://www.uniprot.org/uniprot/P23585 https://www.genome.jp/entry/sce:YHR094C YHR094C and YMR011W could not transport sorbose +r_2105 (YDL245C or YLL043W) keep the original grRules +r_4168 YBR241C https://www.yeastgenome.org/locus/S000003072 https://www.uniprot.org/uniprot/P53142 https://www.genome.jp/entry/sce:YGL104C "YGL104C involved in protein sorting, not sugar transport" +r_4169 YBR241C https://www.yeastgenome.org/locus/S000003072 https://www.uniprot.org/uniprot/P53142 https://www.genome.jp/entry/sce:YGL104C "YGL104C involved in protein sorting, not sugar transport" +r_4592 (YGR191W or YOL130W) https://www.yeastgenome.org/locus/S000003423 https://www.uniprot.org/uniprot/P06775 https://www.genome.jp/entry/sce:YGR191W fixed in Yeast8.5.0 +r_3961 (YER053C or YJR077C) https://www.yeastgenome.org/locus/S000004340 https://www.uniprot.org/uniprot/Q06143 https://www.genome.jp/entry/sce:YLR348C YLR348C transport dicarboxylic acids not phosphate +r_1684 (YGL077C or YOR161C) keep the original grRules +r_1101 (YDL210W or YOR348C) keep the original grRules +r_1176 (YER056C or YER060W or YER060W-A) https://www.yeastgenome.org/locus/S000003154 https://www.uniprot.org/uniprot/P53099 https://www.genome.jp/entry/sce:YGL186C YGL186C is Vitamin transport not guanine +r_1212 (YOL092W or YBR293W or YCL069W or YMR088C) keep the original grRules +r_1096 (YNL065W or YKL217W) https://www.yeastgenome.org/locus/S000005009; https://www.yeastgenome.org/locus/S000001700 https://www.uniprot.org/uniprot/P53943; https://www.uniprot.org/uniprot/P36035 https://www.genome.jp/entry/sce:YNL065W; https://www.genome.jp/entry/sce:YKL217W mevalonate is a short-chain monocarboxylic acid +r_1585 (YNL065W or YKL217W) https://www.yeastgenome.org/locus/S000005009; https://www.yeastgenome.org/locus/S000001700 https://www.uniprot.org/uniprot/P53943; https://www.uniprot.org/uniprot/P36035 https://www.genome.jp/entry/sce:YNL065W; https://www.genome.jp/entry/sce:YKL217W oxobutanoate is a short-chain monocarboxylic acid +r_4698 (YNL065W or YKL217W) https://www.yeastgenome.org/locus/S000005009; https://www.yeastgenome.org/locus/S000001700 https://www.uniprot.org/uniprot/P53943; https://www.uniprot.org/uniprot/P36035 https://www.genome.jp/entry/sce:YNL065W; https://www.genome.jp/entry/sce:YKL217W propionate is a short-chain monocarboxylic acid +r_1770 YBR041W https://www.yeastgenome.org/locus/S000000245 https://www.uniprot.org/uniprot/P38225 https://www.genome.jp/entry/sce:YBR041W https://www.tcdb.org/search/result.php?tc=4.C.1.1.2 fatty acid transport +r_1775 YBR041W https://www.yeastgenome.org/locus/S000000245 https://www.uniprot.org/uniprot/P38225 https://www.genome.jp/entry/sce:YBR041W https://www.tcdb.org/search/result.php?tc=4.C.1.1.3 fatty acid transport +r_1835 YBR041W https://www.yeastgenome.org/locus/S000000245 https://www.uniprot.org/uniprot/P38225 https://www.genome.jp/entry/sce:YBR041W https://www.tcdb.org/search/result.php?tc=4.C.1.1.4 fatty acid transport +r_1836 YBR041W https://www.yeastgenome.org/locus/S000000245 https://www.uniprot.org/uniprot/P38225 https://www.genome.jp/entry/sce:YBR041W https://www.tcdb.org/search/result.php?tc=4.C.1.1.5 fatty acid transport +r_1981 YBR041W https://www.yeastgenome.org/locus/S000000245 https://www.uniprot.org/uniprot/P38225 https://www.genome.jp/entry/sce:YBR041W https://www.tcdb.org/search/result.php?tc=4.C.1.1.6 fatty acid transport +r_2186 YBR041W https://www.yeastgenome.org/locus/S000000245 https://www.uniprot.org/uniprot/P38225 https://www.genome.jp/entry/sce:YBR041W https://www.tcdb.org/search/result.php?tc=4.C.1.1.7 fatty acid transport +r_2192 YBR041W https://www.yeastgenome.org/locus/S000000245 https://www.uniprot.org/uniprot/P38225 https://www.genome.jp/entry/sce:YBR041W https://www.tcdb.org/search/result.php?tc=4.C.1.1.8 fatty acid transport diff --git a/data/modelCuration/v8_6_0/transRxnNewGPRGenes.tsv b/data/modelCuration/v8_6_0/transRxnNewGPRGenes.tsv new file mode 100644 index 00000000..72d55364 --- /dev/null +++ b/data/modelCuration/v8_6_0/transRxnNewGPRGenes.tsv @@ -0,0 +1,2 @@ +genes geneShortName ncbigene refseq uniprot kegg.genes ecogene hprd asap ccds ncbiprotein +YIL166C SOA1 854640 NM_001179514 P40445 sce:YIL166C NP_012100 diff --git a/data/modelCuration/v8_6_0/uniqueSubsystems.tsv b/data/modelCuration/v8_6_0/uniqueSubsystems.tsv new file mode 100644 index 00000000..33a9d0e0 --- /dev/null +++ b/data/modelCuration/v8_6_0/uniqueSubsystems.tsv @@ -0,0 +1,4059 @@ +ID NAME EQUATION GENE ASSOCIATION subsystem_unique_@2021_12 argumentation +r_0001 (R)-lactate:ferricytochrome-c 2-oxidoreductase (R)-lactate[c] + 2 ferricytochrome c[m] => 2 ferrocytochrome c[m] + pyruvate[c] (YDL174C and YEL039C) or (YDL174C and YJR048W) or (YEL039C and YEL071W) or (YEL071W and YJR048W) Pyruvate metabolism +r_0002 (R)-lactate:ferricytochrome-c 2-oxidoreductase (R)-lactate[m] + 2 ferricytochrome c[m] => 2 ferrocytochrome c[m] + pyruvate[m] (YDL178W and YEL039C) or (YDL178W and YJR048W) Pyruvate metabolism +r_0003 (R,R)-butanediol dehydrogenase (R,R)-2,3-butanediol[c] + NAD[c] <=> (R)-acetoin[c] + H+[c] + NADH[c] YAL060W Butanoate metabolism +r_0004 (S)-lactate:ferricytochrome-c 2-oxidoreductase (S)-lactate[c] + 2 ferricytochrome c[m] => 2 ferrocytochrome c[m] + pyruvate[c] (YEL039C and YML054C) or (YJR048W and YML054C) Pyruvate metabolism +r_0005 1,3-beta-glucan synthase UDP-D-glucose[c] => (1->3)-beta-D-glucan[ce] + H+[c] + UDP[c] YGR032W or YMR306W or (YLR342W and YCR034W) Starch and sucrose metabolism +r_0006 1,6-beta-glucan synthase UDP-D-glucose[c] => (1->6)-beta-D-glucan[ce] + H+[c] + UDP[c] YGR143W or YPR159W Starch and sucrose metabolism +r_0007 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerase 1-(5-phospho-D-ribosyl)-5-[(5-phospho-D-ribosylamino)methylideneamino]imidazole-4-carboxamide[c] => 5-[(5-phospho-1-deoxy-D-ribulos-1-ylamino)methylideneamino]-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide[c] YIL020C Histidine metabolism +r_0012 1-pyrroline-5-carboxylate dehydrogenase 1-pyrroline-5-carboxylate[m] + 2 H2O[m] + NAD[m] => H+[m] + L-glutamate[m] + NADH[m] YHR037W Alanine, aspartate and glutamate metabolism +r_0013 2,3-diketo-5-methylthio-1-phosphopentane degradation reaction 5-(methylsulfanyl)-2,3-dioxopentyl phosphate[c] + 3 H2O[c] => 4-methylthio-2-oxobutanoate[c] + formate[c] + 6 H+[c] + phosphate[c] YEL038W and YMR009W Cysteine and methionine metabolism +r_0014 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate deaminase 2,5-diamino-6-(5-phosphono)ribitylamino-4(3H)-pyrimidinone[c] + H+[c] + H2O[c] => 5-amino-6-(5-phosphoribitylamino)uracil[c] + ammonium[c] YOL066C Riboflavin metabolism +r_0015 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase (NADPH) 2,5-diamino-4-hydroxy-6-(5-phosphoribosylamino)pyrimidine[c] + H+[c] + NADPH[c] => 2,5-diamino-6-(5-phosphono)ribitylamino-4(3H)-pyrimidinone[c] + NADP(+)[c] YBR153W Riboflavin metabolism +r_0016 2-aceto-2-hydroxybutanoate synthase 2-oxobutanoate[m] + H+[m] + pyruvate[m] => (S)-2-acetyl-2-hydroxybutanoate[m] + carbon dioxide[m] (YCL009C and YMR108W) or YMR108W Valine, leucine and isoleucine metabolism +r_0017 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase 2-amino-6-(hydroxymethyl)-7,8-dihydropteridin-4-ol[m] + ATP[m] => (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl trihydrogen diphosphate[m] + AMP[m] + H+[m] YNL256W Folate biosynthesis +r_0018 2-aminoadipate transaminase 2-oxoadipic acid[c] + L-glutamate[c] <=> 2-oxoglutarate[c] + L-2-aminoadipate[c] YER152C or YGL202W or YJL060W Lysine metabolism +r_0019 2-dehydropantoate 2-reductase 2-dehydropantoate[c] + H+[c] + NADPH[c] => (R)-pantoate[c] + NADP(+)[c] YHR063C Pantothenate and coa biosynthesis +r_0020 2-deoxy-D-arabino-heptulosonate 7-phosphate synthetase D-erythrose 4-phosphate[m] + H2O[m] + phosphoenolpyruvate[m] => 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonic acid[m] + phosphate[m] YDR035W or YBR249C Phenylalanine, tyrosine and tryptophan biosynthesis +r_0021 2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase 2-hexaprenyl-6-methoxy-1,4-benzoquinone[m] + S-adenosyl-L-methionine[m] => 2-hexaprenyl-6-methoxy-3-methyl-1,4-benzoquinone[m] + H+[m] + S-adenosyl-L-homocysteine[m] YDR204W and YGL119W and YGR255C and YLR201C and YML110C and YOL096C and YOR125C Ubiquinone and other terpenoid-quinone biosynthesis +r_0022 2-hexaprenyl-6-methoxyphenol monooxygenase 2-hexaprenyl-6-methoxyphenol[m] + oxygen[m] => 2-hexaprenyl-6-methoxy-1,4-benzoquinone[m] + H2O[m] YDR204W and YGL119W and YGR255C and YLR201C and YML110C and YOL096C and YOR125C Ubiquinone and other terpenoid-quinone biosynthesis +r_0023 2-isopropylmalate hydratase 2-isopropylmaleic acid[c] + H2O[c] <=> 2-isopropylmalate[c] YGL009C Valine, leucine and isoleucine metabolism +r_0024 2-isopropylmalate synthase 3-methyl-2-oxobutanoate[c] + acetyl-CoA[c] + H2O[c] => 2-isopropylmalate[c] + coenzyme A[c] + H+[c] YNL104C or YOR108W Valine, leucine and isoleucine metabolism +r_0025 2-isopropylmalate synthase 3-methyl-2-oxobutanoate[m] + acetyl-CoA[m] + H2O[m] => 2-isopropylmalate[m] + coenzyme A[m] + H+[m] YNL104C Valine, leucine and isoleucine metabolism +r_0026 2-keto-4-methylthiobutyrate transamination 4-methylthio-2-oxobutanoate[c] + L-glutamate[c] => 2-oxoglutarate[c] + L-methionine[c] YHR208W or YJR148W or YGL202W or YHR137W Cysteine and methionine metabolism +r_0027 2-methylcitrate dehydratase homocitrate[m] <=> but-1-ene-1,2,4-tricarboxylic acid[m] + H2O[m] YDR234W Lysine metabolism +r_0028 2-methylcitrate synthase H2O[m] + oxaloacetate[m] + propionyl-CoA[m] => 2-methylcitrate[m] + coenzyme A[m] + H+[m] YPR001W Propanoate metabolism +r_0029 2-oxo-4-methyl-3-carboxypentanoate decarboxylation (2S)-2-isopropyl-3-oxosuccinate[c] + H+[c] => 4-methyl-2-oxopentanoate[c] + carbon dioxide[c] YJR148W Valine, leucine and isoleucine metabolism +r_0030 2-oxo-4-methyl-3-carboxypentanoate decarboxylation (2S)-2-isopropyl-3-oxosuccinate[m] + H+[m] => 4-methyl-2-oxopentanoate[m] + carbon dioxide[m] YHR208W Valine, leucine and isoleucine metabolism +r_0032 3',5'-bisphosphate nucleotidase adenosine 3',5'-bismonophosphate[c] + H2O[c] => AMP[c] + phosphate[c] YOL064C Sulfur metabolism +r_0033 3',5'-cyclic-nucleotide phosphodiesterase 3',5'-cyclic AMP[c] + H2O[c] => AMP[c] + H+[c] YGL248W or YOR360C Purine metabolism +r_0034 3',5'-cyclic-nucleotide phosphodiesterase 3',5'-cyclic dAMP[c] + H2O[c] => dAMP[c] + H+[c] YOR360C Purine metabolism +r_0035 3',5'-cyclic-nucleotide phosphodiesterase 3',5'-cyclic IMP[c] + H2O[c] => H+[c] + IMP[c] YOR360C Purine metabolism +r_0036 3',5'-cyclic-nucleotide phosphodiesterase 3',5'-cyclic GMP[c] + H2O[c] => GMP[c] + H+[c] YOR360C Purine metabolism +r_0037 3',5'-cyclic-nucleotide phosphodiesterase 3',5'-cyclic CMP[c] + H2O[c] => CMP[c] + H+[c] YOR360C Purine metabolism +r_0038 3,4-dihydroxy-2-butanone-4-phosphate synthase D-ribulose 5-phosphate[c] => 2-hydroxy-3-oxobutyl phosphate[c] + formate[c] + H+[c] YDR487C Riboflavin metabolism +r_0039 3-dehydroquinate dehydratase 3-dehydroquinate[c] => 3-dehydroshikimate[c] + H2O[c] YDR127W Phenylalanine, tyrosine and tryptophan biosynthesis +r_0040 3-dehydroquinate synthase 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonic acid[c] => 3-dehydroquinate[c] + phosphate[c] YDR127W Phenylalanine, tyrosine and tryptophan biosynthesis +r_0041 3-dehydrosphinganine reductase 3-ketosphinganine[er] + H+[er] + NADPH[er] => NADP(+)[er] + sphinganine[er] YBR265W Sphingolipid metabolism +r_0042 3-deoxy-D-arabino-heptulosonate 7-phosphate synthetase D-erythrose 4-phosphate[c] + H2O[c] + phosphoenolpyruvate[c] => 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonic acid[c] + phosphate[c] YBR249C or YDR035W Phenylalanine, tyrosine and tryptophan biosynthesis +r_0043 3-hexaprenyl-4,5-dihydroxybenzoate hydroxylase 3-hexaprenyl-4-hydroxybenzoic acid[c] + 0.5 oxygen[c] => 3-hexaprenyl-4,5-dihydroxybenzoic acid[c] YPL252C or YDR376W Ubiquinone and other terpenoid-quinone biosynthesis +r_0044 3-hexaprenyl-4-hydroxy-5-methoxybenzoate decarboxylase 3-hexaprenyl-4-hydroxy-5-methoxybenzoic acid[m] + H+[m] => 2-hexaprenyl-6-methoxyphenol[m] + carbon dioxide[m] YDR538W and YDR539W Ubiquinone and other terpenoid-quinone biosynthesis +r_0045 3-hydroxy-L-kynurenine hydrolase 3-hydroxy-L-kynurenine[c] + H2O[c] => 3-hydroxyanthranilate[c] + H+[c] + L-alanine[c] YLR231C Tryptophan metabolism +r_0057 3-hydroxyacyl-CoA dehydrogenase (3-oxotetradecanoyl-CoA) (S)-3-hydroxytetradecanoyl-CoA[p] + NAD[p] => 3-oxotetradecanoyl-CoA[p] + H+[p] + NADH[p] YKR009C Fatty acid degradation +r_0058 3-hydroxyanthranilate 3,4-dioxygenase 3-hydroxyanthranilate[c] + oxygen[c] => 2-amino-3-carboxymuconate-6-semialdehyde[c] YJR025C Tryptophan metabolism +r_0059 3-isopropylmalate 3-methyltransferase (2R,3S)-3-isopropylmalate[c] + S-adenosyl-L-methionine[c] => 3-hydroxy-2-isopropyl-4-methoxy-4-oxobutanoate[c] + S-adenosyl-L-homocysteine[c] YER175C Complex alcohol metabolism +r_0060 3-isopropylmalate dehydratase (2R,3S)-3-isopropylmalate[c] <=> 2-isopropylmaleic acid[c] + H2O[c] YGL009C Valine, leucine and isoleucine metabolism +r_0061 3-isopropylmalate dehydrogenase (2R,3S)-3-isopropylmalate[c] + NAD[c] => (2S)-2-isopropyl-3-oxosuccinate[c] + H+[c] + NADH[c] YCL018W Valine, leucine and isoleucine metabolism +r_0062 3-methyl-2-oxobutanoate decarboxylase 3-methyl-2-oxobutanoate[c] + H+[c] => carbon dioxide[c] + isobutyraldehyde[c] YGR087C or YLR044C or YLR134W Complex alcohol metabolism +r_0063 3-methyl-2-oxobutanoate hydroxymethyltransferase 3-methyl-2-oxobutanoate[m] + 5,10-methylenetetrahydrofolate[m] + H2O[m] => 2-dehydropantoate[m] + THF[m] YBR176W Pantothenate and coa biosynthesis +r_0064 3-methyl-2-oxopentanoate decarboxylase (S)-3-methyl-2-oxopentanoate[c] + H+[c] => 2-methylbutanal[c] + carbon dioxide[c] YDL080C or YGR087C or YLR044C or YLR134W Complex alcohol metabolism +r_0065 3-phosphoshikimate 1-carboxyvinyltransferase 3-phosphoshikimic acid[c] + phosphoenolpyruvate[c] => 5-O-(1-carboxyvinyl)-3-phosphoshikimic acid[c] + phosphate[c] YDR127W Phenylalanine, tyrosine and tryptophan biosynthesis +r_0066 4-amino-4-deoxychorismate synthase chorismate[c] + L-glutamine[c] => 4-amino-4-deoxychorismate[c] + L-glutamate[c] YNR033W Folate biosynthesis +r_0067 4-aminobenzoate synthase 4-amino-4-deoxychorismate[c] => 4-aminobenzoate[c] + H+[c] + pyruvate[c] YMR289W Folate biosynthesis +r_0068 4-aminobutyrate transaminase 2-oxoglutarate[c] + gamma-aminobutyrate[c] => L-glutamate[c] + succinic semialdehyde[c] YGR019W Alanine, aspartate and glutamate metabolism +r_0069 4-hydroxy-L-threonine synthase 4-(phosphonooxy)-L-threonine[c] + H2O[c] => 4-hydroxy-L-threonine[c] + phosphate[c] YCR053W Vitamin b6 metabolism +r_0070 4-hydroxybenzoate formation 4-hydroxybenzoyl-CoA[m] + H2O[m] => 4-hydroxybenzoate[m] + coenzyme A[m] + H+[m] Ubiquinone and other terpenoid-quinone biosynthesis +r_0072 4-methyl-2-oxopentanoate decarboxylase 4-methyl-2-oxopentanoate[c] + H+[c] => 3-methylbutanal[c] + carbon dioxide[c] YDL080C Complex alcohol metabolism +r_0073 4PP-IP5 depyrophosphorylation to IP6 4-diphospho-1D-myo-inositol pentakisphosphate[c] + H2O[c] => H+[c] + myo-inositol hexakisphosphate[c] + phosphate[c] YLR410W or YOR163W Inositol phosphate metabolism +r_0074 4PP-IP5 pyrophosphorylation to 4,5-PP2-IP4 4-diphospho-1D-myo-inositol pentakisphosphate[c] + ATP[c] + H+[c] => 4,5-bis(diphospho)-1D-myo-inositol tetrakisphosphate[c] + ADP[c] YDR017C Phosphatidylinositol signaling system +r_0075 5'-methylthioadenosine phosphorylase 5'-S-methyl-5'-thioadenosine[c] + phosphate[c] => adenine[c] + S-methyl-5-thio-alpha-D-ribose 1-phosphate[c] YLR017W Cysteine and methionine metabolism +r_0076 5'-nucleotidase (CMP) CMP[c] + H2O[c] => cytidine[c] + phosphate[c] YER037W or YGL224C Nicotinate and nicotinamide metabolism +r_0077 5'-nucleotidase (IMP) H2O[c] + IMP[c] => inosine[c] + phosphate[c] YOR155C Purine metabolism +r_0078 5'-nucleotidase (UMP) H2O[c] + UMP[c] => phosphate[c] + uridine[c] YER037W or YGL224C Nicotinate and nicotinamide metabolism +r_0079 5'-phosphoribosylformyl glycinamidine synthetase 5'-phosphoribosyl-N-formylglycineamide[c] + ATP[c] + H2O[c] + L-glutamine[c] => 5'-phosphoribosyl-N-formylglycineamidine[c] + ADP[c] + H+[c] + L-glutamate[c] + phosphate[c] YGR061C Purine metabolism +r_0080 5,10-methylenetetrahydrofolate reductase (NADPH) 5,10-methylenetetrahydrofolate[c] + H+[c] + NADPH[c] => 5-methyltetrahydrofolate[c] + NADP(+)[c] YGL125W or YPL023C One carbon pool by folate +r_0081 5-aminolevulinate synthase H+[m] + L-glycine[m] + succinyl-CoA[m] => 5-aminolevulinate[m] + carbon dioxide[m] + coenzyme A[m] YDR232W Porphyrin and chlorophyll metabolism +r_0082 5-diphosphoinositol-1,2,3,4,6-pentakisphosphate diphosphohydrolase 5-diphospho-1D-myo-inositol pentakisphosphate[c] + H2O[c] => H+[c] + myo-inositol hexakisphosphate[c] + phosphate[c] YOR163W Inositol phosphate metabolism +r_0083 5-diphosphoinositol-1,2,3,4,6-pentakisphosphate synthase ATP[c] + myo-inositol hexakisphosphate[c] => 5-diphospho-1D-myo-inositol pentakisphosphate[c] + ADP[c] YDR017C Phosphatidylinositol signaling system +r_0084 5-formethyltetrahydrofolate cyclo-ligase 5-formyltetrahydrofolic acid[c] + ATP[c] => 5,10-methenyl-THF[c] + ADP[c] + phosphate[c] YER183C One carbon pool by folate +r_0085 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase 5-methyltetrahydropteroyltri-L-glutamic acid[c] + L-homocysteine[c] => L-methionine[c] + tetrahydropteroyltri-L-glutamic acid[c] YER091C Cysteine and methionine metabolism +r_0086 5-methylthio-5-deoxy-D-ribulose 1-phosphate dehydratase S-methyl-5-thio-D-ribulose 1-phosphate[c] => 5-(methylsulfanyl)-2,3-dioxopentyl phosphate[c] + H2O[c] YJR024C Cysteine and methionine metabolism +r_0087 5-methylthioribose-1-phosphate isomerase S-methyl-5-thio-alpha-D-ribose 1-phosphate[c] <=> S-methyl-5-thio-D-ribulose 1-phosphate[c] YPR118W Cysteine and methionine metabolism +r_0088 5PP-IP5 pyrophosphorylation to 4,5-PP2-IP4 5-diphospho-1D-myo-inositol pentakisphosphate[c] + 2 H+[c] + phosphate[c] <=> 4,5-bis(diphospho)-1D-myo-inositol tetrakisphosphate[c] + H2O[c] YLR410W Inositol phosphate metabolism +r_0089 5PP-IP5 pyrophosphorylation to 5,6-PP2-IP4 5-diphospho-1D-myo-inositol pentakisphosphate[c] + 2 H+[c] + phosphate[c] <=> 5,6-bis(diphospho)-1D-myo-inositol tetrakisphosphate[c] + H2O[c] YLR410W Inositol phosphate metabolism +r_0090 6-phosphofructo-2-kinase ATP[c] + D-fructose 6-phosphate[c] => ADP[c] + beta-D-fructose 2,6-bisphosphate[c] + H+[c] YIL107C or YOL136C Fructose and mannose metabolism +r_0091 6-phosphogluconolactonase 6-O-phosphono-D-glucono-1,5-lactone[c] + H2O[c] => 6-phospho-D-gluconate[c] + H+[c] YGR248W or YHR163W Pentose phosphate pathway +r_0092 6PP-IP5 depyrophosphorylation to IP6 6-diphospho-1D-myo-inositol pentakisphosphate[c] + H2O[c] => H+[c] + myo-inositol hexakisphosphate[c] + phosphate[c] YLR410W or YOR163W Inositol phosphate metabolism +r_0093 6PP-IP5 pyrophosphorylation to 5,6-PP2-IP4 6-diphospho-1D-myo-inositol pentakisphosphate[c] + ATP[c] + H+[c] => 5,6-bis(diphospho)-1D-myo-inositol tetrakisphosphate[c] + ADP[c] YDR017C Phosphatidylinositol signaling system +r_0094 8-amino-7-oxononanoate synthase H+[c] + L-alanine[c] + pimeloyl-CoA[c] => 8-amino-7-oxononanoate[c] + carbon dioxide[c] + coenzyme A[c] Biotin metabolism +r_0095 acetaldehyde condensation 2 acetaldehyde[c] => (R)-acetoin[c] YGR087C or YLR044C or YLR134W Butanoate metabolism +r_0096 acetohydroxy acid isomeroreductase 2-acetyllactic acid[m] + H+[m] + NADPH[m] => (R)-2,3-dihydroxy-3-methylbutanoate[m] + NADP(+)[m] YLR355C Valine, leucine and isoleucine metabolism +r_0097 acetolactate synthase H+[m] + 2 pyruvate[m] => 2-acetyllactic acid[m] + carbon dioxide[m] (YCL009C and YMR108W) or YMR108W Valine, leucine and isoleucine metabolism +r_0099 acetyl-CoA ACP transacylase acetyl-CoA[m] + ACP1[m] <=> acetyl-ACP[m] + coenzyme A[m] YKL192C Fatty acid biosynthesis +r_0100 acetyl-CoA C-acyltransferase (palmitoyl-CoA) 3-oxooctadecanoyl-CoA[p] + coenzyme A[p] => acetyl-CoA[p] + palmitoyl-CoA[p] YIL160C Fatty acid degradation +r_0101 acetyl-CoA C-acyltransferase (tetracosanoyl-CoA) 3-oxohexacosanoyl-CoA[p] + coenzyme A[p] => acetyl-CoA[p] + tetracosanoyl-CoA[p] YIL160C Fatty acid degradation +r_0102 acetyl-CoA C-acyltransferase (myristoyl-CoA) 3-oxopalmitoyl-CoA[p] + coenzyme A[p] => acetyl-CoA[p] + myristoyl-CoA[p] YIL160C Fatty acid degradation +r_0103 acetyl-CoA C-acetyltransferase 2 acetyl-CoA[c] <=> acetoacetyl-CoA[c] + coenzyme A[c] YPL028W Fatty acid degradation +r_0104 acetyl-CoA C-acetyltransferase 2 acetyl-CoA[m] <=> acetoacetyl-CoA[m] + coenzyme A[m] YPL028W Fatty acid degradation +r_0105 acetyl-CoA C-acyltransferase (lauroyl-CoA) 3-oxotetradecanoyl-CoA[p] + coenzyme A[p] => acetyl-CoA[p] + lauroyl-CoA[p] YIL160C Fatty acid degradation +r_0106 acetyl-CoA C-acyltransferase (octanoyl-CoA) 3-oxodecanoyl-CoA[p] + coenzyme A[p] => acetyl-CoA[p] + octanoyl-CoA[p] YIL160C Fatty acid degradation +r_0107 acetyl-CoA C-acyltransferase (decanoyl-CoA) 3-oxolauroyl-CoA[p] + coenzyme A[p] => acetyl-CoA[p] + decanoyl-CoA[p] YIL160C Fatty acid degradation +r_0108 acetyl-Coa carboxylase acetyl-CoA[m] + ATP[m] + bicarbonate[m] => ADP[m] + H+[m] + malonyl-CoA[m] + phosphate[m] YMR207C Fatty acid biosynthesis +r_0109 acetyl-CoA carboxylase, reaction acetyl-CoA[c] + ATP[c] + bicarbonate[c] => ADP[c] + H+[c] + malonyl-CoA[c] + phosphate[c] YDL141W and YNR016C Fatty acid biosynthesis +r_0111 acetyl-CoA hydrolase acetyl-CoA[m] + H2O[m] => acetate[m] + coenzyme A[m] + H+[m] YBL015W Pyruvate metabolism +r_0112 acetyl-CoA synthetase acetate[c] + ATP[c] + coenzyme A[c] => acetyl-CoA[c] + AMP[c] + diphosphate[c] YAL054C or YLR153C Pyruvate metabolism +r_0113 acetyl-CoA synthetase acetate[m] + ATP[m] + coenzyme A[m] => acetyl-CoA[m] + AMP[m] + diphosphate[m] YAL054C Pyruvate metabolism +r_0114 acetyl-CoA synthetase nuclear acetate[n] + ATP[n] + coenzyme A[n] => acetyl-CoA[n] + AMP[n] + diphosphate[n] YLR153C Pyruvate metabolism +r_0115 acetylglutamate kinase ATP[m] + N-acetyl-L-glutamate[m] => ADP[m] + N-acetyl-L-gamma-glutamyl phosphate[m] YER069W Arginine biosynthesis +r_0116 acid phosphatase (secreted) FMN[e] + H2O[e] => phosphate[e] + riboflavin[e] YBR093C or YAR071W or YBR092C or YHR215W Riboflavin metabolism +r_0117 aconitase 2-methylcitrate[m] <=> (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylic acid[m] YPR002W Propanoate metabolism +r_0118 acteylornithine transaminase 2-acetamido-5-oxopentanoate[m] + L-glutamate[m] => 2-oxoglutarate[m] + N(2)-acetyl-L-ornithine[m] YOL140W Arginine biosynthesis +r_0119 acyl carrier protein synthase coenzyme A[m] + H2O[m] => adenosine 3',5'-bismonophosphate[m] + 2 H+[m] + pantetheine 4'-phosphate[m] YPL148C Pantothenate and coa biosynthesis +r_0120 acyl-CoA oxidase (decanoyl-CoA) decanoyl-CoA[p] + oxygen[p] => hydrogen peroxide[p] + trans-dec-2-enoyl-CoA[p] YGL205W Fatty acid degradation +r_0121 acyl-CoA oxidase (dodecanoyl-CoA) lauroyl-CoA[p] + oxygen[p] => hydrogen peroxide[p] + trans-dodec-2-enoyl-CoA[p] YGL205W Fatty acid degradation +r_0122 acyl-CoA oxidase (hexacosanoyl-CoA) hexacosanoyl-CoA[p] + oxygen[p] => hydrogen peroxide[p] + trans-hexacos-2-enoyl-CoA[p] YGL205W Fatty acid degradation +r_0123 acyl-CoA oxidase (hexadecanoyl-CoA) oxygen[p] + palmitoyl-CoA[p] => hexadec-2-enoyl-CoA[p] + hydrogen peroxide[p] YGL205W Fatty acid degradation +r_0124 acyl-CoA oxidase (octadecanoyl-CoA) oxygen[p] + stearoyl-CoA[p] => hydrogen peroxide[p] + trans-octadec-2-enoyl-CoA[p] YGL205W Fatty acid degradation +r_0125 acyl-CoA oxidase (tetradecanoyl-CoA) myristoyl-CoA[p] + oxygen[p] => hydrogen peroxide[p] + trans-tetradec-2-enoyl-CoA[p] YGL205W Fatty acid degradation +r_0126 acyl-CoA:sterol acyltransferase (oleoyl-CoA:episterol), ER membrane oleoyl-CoA[erm] + episterol[erm] <=> coenzyme A[erm] + episteryl oleate[erm] YCR048W Steroid biosynthesis +r_0127 acyl-CoA:sterol acyltransferase (oleoyl-CoA:ergosterol), ER membrane oleoyl-CoA[erm] + ergosterol[erm] => coenzyme A[erm] + ergosteryl oleate[erm] YCR048W or YNR019W Steroid biosynthesis +r_0128 acyl-CoA:sterol acyltransferase (oleoyl-CoA:fecosterol), ER membrane oleoyl-CoA[erm] + fecosterol[erm] <=> coenzyme A[erm] + fecosteryl oleate[erm] YCR048W Steroid biosynthesis +r_0129 acyl-CoA:sterol acyltransferase (oleoyl-CoA:lanosterol), ER membrane oleoyl-CoA[erm] + lanosterol[erm] => coenzyme A[erm] + lanosteryl oleate[erm] YCR048W Steroid biosynthesis +r_0130 acyl-CoA:sterol acyltransferase (oleoyl-CoA:zymosterol), ER membrane oleoyl-CoA[erm] + zymosterol[erm] <=> coenzyme A[erm] + zymosteryl oleate[erm] YCR048W Steroid biosynthesis +r_0131 acyl-CoA:sterol acyltransferase (palmitoleoyl-CoA:episterol), ER membrane palmitoleoyl-CoA(4-)[erm] + episterol[erm] <=> coenzyme A[erm] + episteryl palmitoleate[erm] YCR048W Steroid biosynthesis +r_0132 acyl-CoA:sterol acyltransferase (palmitoleoyl-CoA:ergosterol), ER membrane palmitoleoyl-CoA(4-)[erm] + ergosterol[erm] <=> coenzyme A[erm] + ergosteryl palmitoleate[erm] YCR048W or YNR019W Steroid biosynthesis +r_0133 acyl-CoA:sterol acyltransferase (palmitoleoyl-CoA:fecosterol), ER membrane palmitoleoyl-CoA(4-)[erm] + fecosterol[erm] <=> coenzyme A[erm] + fecosteryl palmitoleate[erm] YCR048W Steroid biosynthesis +r_0134 acyl-CoA:sterol acyltransferase (palmitoleoyl-CoA:lanosterol), ER membrane palmitoleoyl-CoA(4-)[erm] + lanosterol[erm] <=> coenzyme A[erm] + lanosteryl palmitoleate[erm] YCR048W Steroid biosynthesis +r_0135 acyl-CoA:sterol acyltransferase (palmitoleoyl-CoA:zymosterol), ER membrane palmitoleoyl-CoA(4-)[erm] + zymosterol[erm] <=> coenzyme A[erm] + zymosteryl palmitoleate[erm] YCR048W Steroid biosynthesis +r_0137 acylation of GPI inositol at 2 position, GPI-anchor assembly, step 3 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol[er] + palmitoyl-CoA[er] <=> 6-(alpha-D-glucosaminyl)-O-acyl-1-phosphatidyl-1D-myo-inositol[er] + coenzyme A[er] YJL091C Glycosylphosphatidylinositol (gpi)-anchor biosynthesis +r_0138 adenine deaminase adenine[c] + H+[c] + H2O[c] => ammonium[c] + hypoxanthine[c] YNL141W Purine metabolism +r_0139 adenine phosphoribosyltransferase adenine[c] + PRPP[c] => AMP[c] + diphosphate[c] YDR441C or YML022W Purine metabolism +r_0140 adenosine deaminase adenosine[c] + H+[c] + H2O[c] => ammonium[c] + inosine[c] YNL141W Purine metabolism +r_0142 adenosine kinase adenosine[c] + ATP[c] => ADP[c] + AMP[c] + H+[c] YJR105W Purine metabolism +r_0143 adenosine monophosphate deaminase AMP[c] + H+[c] + H2O[c] => ammonium[c] + IMP[c] YML035C Purine metabolism +r_0144 adenosylhomocysteinase H2O[c] + S-adenosyl-L-homocysteine[c] => adenosine[c] + L-homocysteine[c] YER043C Cysteine and methionine metabolism +r_0145 adenosylmethionine decarboxylase H+[c] + S-adenosyl-L-methionine[c] => carbon dioxide[c] + S-adenosylmethioninamine[c] YOL052C Arginine and proline metabolism +r_0146 adenosylmethionine-8-amino-7-oxononanoate transaminase 8-amino-7-oxononanoate[c] + S-adenosyl-L-methionine[c] <=> 7,8-diaminononanoate[c] + S-adenosyl-4-methylthio-2-oxobutanoate[c] YNR058W Biotin metabolism +r_0147 adenylate cyclase ATP[c] => 3',5'-cyclic AMP[c] + diphosphate[c] YJL005W Purine metabolism +r_0148 adenylate kinase AMP[c] + ATP[c] => 2 ADP[c] YDL166C or YDR226W Purine metabolism +r_0149 adenylate kinase AMP[m] + ATP[m] => 2 ADP[m] YER170W Purine metabolism +r_0150 adenylate kinase (GTP) AMP[m] + GTP[m] <=> ADP[m] + GDP[m] YER170W Purine metabolism +r_0151 adenylosuccinate lyase (AICAR) 5'-phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole[c] => AICAR[c] + fumarate[c] YLR359W Purine metabolism +r_0152 adenylosuccinate lyase adenylo-succinate[c] <=> AMP[c] + fumarate[c] YLR359W Purine metabolism +r_0153 adenylosuccinate synthase GTP[c] + IMP[c] + L-aspartate[c] => adenylo-succinate[c] + GDP[c] + 2 H+[c] + phosphate[c] YNL220W Purine metabolism +r_0154 adenylyl-sulfate kinase 5'-adenylyl sulfate[c] + ATP[c] => 3'-phospho-5'-adenylyl sulfate[c] + ADP[c] + H+[c] YKL001C Sulfur metabolism +r_0155 ADP-ribose 2,3-cyclic phosphodiesterase 2',3'-cyclic AMP[c] + H2O[c] => adenosine 2'-phosphate[c] + H+[c] YGR247W Cyclic nucleotide metabolism https://www.yeastgenome.org/go/GO:0009187 +r_0156 alanine glyoxylate aminotransferase glyoxylate[c] + L-alanine[c] => L-glycine[c] + pyruvate[c] YFL030W Alanine, aspartate and glutamate metabolism +r_0157 alanyl-tRNA synthetase ATP[c] + L-alanine[c] + tRNA(Ala)[c] => Ala-tRNA(Ala)[c] + AMP[c] + diphosphate[c] YOR335C tRNA metabolism https://www.yeastgenome.org/go/GO:0006399 +r_0158 alcohol acetyltransferase (2-methylbutanol) 2-methylbutanol[c] + acetyl-CoA[c] => 2-methylbutyl acetate[c] + coenzyme A[c] YGR177C or YOR377W Complex alcohol metabolism +r_0159 alcohol acetyltransferase (ethanol) acetyl-CoA[c] + ethanol[c] => coenzyme A[c] + ethyl acetate[c] YGR177C or YOR377W Complex alcohol metabolism +r_0160 alcohol acetyltransferase (isoamyl alcohol) acetyl-CoA[c] + isoamylol[c] => coenzyme A[c] + isoamyl acetate[c] YGR177C or YOR377W Complex alcohol metabolism +r_0161 alcohol acetyltransferase (isobutyl alcohol) acetyl-CoA[c] + isobutanol[c] => coenzyme A[c] + isobutyl acetate[c] YGR177C or YOR377W Complex alcohol metabolism +r_0162 alcohol acetyltransferase (phenylethanol alcohol) 2-phenylethanol[c] + acetyl-CoA[c] => coenzyme A[c] + phenethyl acetate[c] YGR177C or YOR377W Complex alcohol metabolism +r_0163 alcohol dehydrogenase (ethanol to acetaldehyde) ethanol[c] + NAD[c] => acetaldehyde[c] + H+[c] + NADH[c] YMR303C Glycolysis / gluconeogenesis +r_0164 alcohol dehydrogenase (glycerol, NADP) D-glyceraldehyde[c] + H+[c] + NADPH[c] => glycerol[c] + NADP(+)[c] YDR368W or YHR104W Glycerolipid metabolism +r_0165 mitochondrial alcohol dehydrogenase acetaldehyde[m] + H+[m] + NADH[m] => ethanol[m] + NAD[m] YGL256W or YMR083W Glycolysis / gluconeogenesis +r_0166 aldehyde dehydrogenase (2-methylbutanol, NAD) 2-methylbutanal[c] + H+[c] + NADH[c] => 2-methylbutanol[c] + NAD[c] YBR145W or YDL168W or YOL086C Complex alcohol metabolism +r_0167 aldehyde dehydrogenase (2-methylbutanol, NAD) 2-methylbutanal[m] + H+[m] + NADH[m] => 2-methylbutanol[m] + NAD[m] YGL256W or YMR083W Complex alcohol metabolism +r_0168 aldehyde dehydrogenase (2-methylbutanol, NADP) 2-methylbutanal[c] + H+[c] + NADPH[c] => 2-methylbutanol[c] + NADP(+)[c] YCR105W or YDR368W or YMR318C Complex alcohol metabolism +r_0169 aldehyde dehydrogenase (2-phenylethanol, NAD) H+[c] + NADH[c] + phenylacetaldehyde[c] => 2-phenylethanol[c] + NAD[c] YBR145W or YDL168W or YOL086C Phenylalanine metabolism +r_0170 aldehyde dehydrogenase (2-phenylethanol, NAD) H+[m] + NADH[m] + phenylacetaldehyde[m] => 2-phenylethanol[m] + NAD[m] YGL256W or YMR083W Phenylalanine metabolism +r_0171 aldehyde dehydrogenase (2-phenylethanol, NADP) H+[c] + NADPH[c] + phenylacetaldehyde[c] => 2-phenylethanol[c] + NADP(+)[c] YCR105W or YMR318C Phenylalanine metabolism +r_0172 aldehyde dehydrogenase (3-aminopropanal, NAD) 3-aminopropanal[c] + H2O[c] + NAD[c] => beta-alanine[c] + 2 H+[c] + NADH[c] YMR110C or YMR169C or YMR170C Beta-alanine metabolism +r_0173 aldehyde dehydrogenase (acetaldehyde, NADP) acetaldehyde[c] + H2O[c] + NADP(+)[c] => acetate[c] + 2 H+[c] + NADPH[c] YPL061W Glycolysis / gluconeogenesis +r_0174 aldehyde dehydrogenase (acetylaldehyde, NAD) acetaldehyde[m] + H2O[m] + NAD[m] => acetate[m] + 2 H+[m] + NADH[m] YOR374W Glycolysis / gluconeogenesis +r_0175 aldehyde dehydrogenase (acetylaldehyde, NADP) acetaldehyde[m] + H2O[m] + NADP(+)[m] => acetate[m] + 2 H+[m] + NADPH[m] YER073W or YOR374W Pyruvate metabolism +r_0176 aldehyde dehydrogenase (indole-3-acetaldehyde, NAD) H2O[m] + indol-3-ylacetaldehyde[m] + NAD[m] => 2 H+[m] + indole-3-acetate[m] + NADH[m] YOR374W Tryptophan metabolism +r_0177 aldehyde dehydrogenase (indole-3-acetaldehyde, NADP) H2O[c] + indol-3-ylacetaldehyde[c] + NADP(+)[c] => 2 H+[c] + indole-3-acetate[c] + NADPH[c] YPL061W Tryptophan metabolism +r_0178 aldehyde dehydrogenase (indole-3-acetaldehyde, NADP) H2O[m] + indol-3-ylacetaldehyde[m] + NADP(+)[m] => 2 H+[m] + indole-3-acetate[m] + NADPH[m] YER073W or YOR374W Tryptophan metabolism +r_0179 aldehyde dehydrogenase (isoamyl alcohol, NAD) 3-methylbutanal[c] + H+[c] + NADH[c] => isoamylol[c] + NAD[c] YBR145W or YDL168W or YOL086C Complex alcohol metabolism +r_0180 aldehyde dehydrogenase (isoamyl alcohol, NAD) 3-methylbutanal[m] + H+[m] + NADH[m] => isoamylol[m] + NAD[m] YGL256W or YMR083W Complex alcohol metabolism +r_0181 aldehyde dehydrogenase (isoamyl alcohol, NADP) 3-methylbutanal[c] + H+[c] + NADPH[c] => isoamylol[c] + NADP(+)[c] YCR105W or YMR318C Complex alcohol metabolism +r_0182 aldehyde dehydrogenase (isobutyl alcohol, NAD) H+[c] + isobutyraldehyde[c] + NADH[c] => isobutanol[c] + NAD[c] YBR145W or YDL168W or YOL086C Complex alcohol metabolism +r_0183 aldehyde dehydrogenase (isobutyl alcohol, NAD) H+[m] + isobutyraldehyde[m] + NADH[m] => isobutanol[m] + NAD[m] YGL256W or YMR083W Complex alcohol metabolism +r_0184 aldehyde dehydrogenase (isobutyl alcohol, NADP) H+[c] + isobutyraldehyde[c] + NADPH[c] => isobutanol[c] + NADP(+)[c] YCR105W or YMR318C Complex alcohol metabolism +r_0185 aldehyde dehydrogenase (phenylacetaldehyde, NAD) H2O[c] + NAD[c] + phenylacetaldehyde[c] => 2 H+[c] + NADH[c] + phenylacetic acid[c] YMR169C or YMR170C Phenylalanine metabolism +r_0186 aldehyde dehydrogenase (tryptophol, NAD) H+[c] + indol-3-ylacetaldehyde[c] + NADH[c] => NAD[c] + tryptophol[c] YBR145W or YDL168W or YOL086C Tyrosine metabolism +r_0187 aldehyde dehydrogenase (tryptophol, NAD) H+[m] + indol-3-ylacetaldehyde[m] + NADH[m] => NAD[m] + tryptophol[m] YGL256W or YMR083W Tyrosine metabolism +r_0188 alkaline phosphatase (dihydroneopterin) 7,8-dihydroneopterin 3'-triphosphate[c] + 3 H2O[c] => 7,8-dihydroneopterin[c] + 2 H+[c] + 3 phosphate[c] YDR481C Folate biosynthesis +r_0189 allantoate amidinohydrolase allantoate[c] + H2O[c] <=> urea[c] + ureidoglycolic acid[c] YIR029W Purine metabolism +r_0190 allantoinase, reaction allantoin[c] + H2O[c] <=> allantoate[c] + H+[c] YIR027C Purine metabolism +r_0191 allophanate hydrolase 3 H+[c] + H2O[c] + urea-1-carboxylic acid[c] => 2 ammonium[c] + 2 carbon dioxide[c] YBR208C Arginine biosynthesis +r_0192 alpha 1,2-mannosyltransferase beta-D-mannosyldiacetylchitobiosyldiphosphodolichol[g] + GDP-alpha-D-mannose[g] + H+[g] => alpha-D-mannosyl-beta-D-mannosyldiacetylchitobiosyldiphosphodolichol[g] + GDP[g] YBR199W or YBR205W or YDR483W or YJL139C or YKR061W or YNL029C or YOR099W or YPL053C N-glycan biosynthesis +r_0193 alpha,alpha-trehalase H2O[v] + trehalose[v] => 2 D-glucose[v] YPR026W or YBR001C Starch and sucrose metabolism +r_0194 alpha,alpha-trehalase H2O[c] + trehalose[c] => 2 D-glucose[c] YDR001C Starch and sucrose metabolism +r_0195 alpha,alpha-trehalose-phosphate synthase (UDP-forming) D-glucose 6-phosphate[c] + UDP-D-glucose[c] => alpha,alpha-trehalose 6-phosphate[c] + H+[c] + UDP[c] (YBR126C and YDR074W and YML100W) or (YBR126C and YDR074W and YMR261C) Starch and sucrose metabolism +r_0198 alpha-glucosidase H2O[c] + maltose[c] => 2 D-glucose[c] YBR299W or YGR287C or YGR292W or YIL172C or YJL216C or YJL221C Starch and sucrose metabolism +r_0199 amidase 4-guanidinobutanamide[c] + H2O[c] => 4-guanidinobutanoic acid[c] + ammonium[c] YDR242W or YMR293C Arginine and proline metabolism +r_0200 Aminoacetone:oxygen oxidoreductase(deaminating)(flavin-containing) aminoacetone[c] + H2O[c] + oxygen[c] => ammonium[c] + hydrogen peroxide[c] + methylglyoxal[c] Glycine, serine and threonine metabolism +r_0201 Aminobutyraldehyde dehydrogenase 4-aminobutanal[m] + H2O[m] + NAD[m] => gamma-aminobutyrate[m] + 2 H+[m] + NADH[m] YOR374W Arginine and proline metabolism +r_0202 anthranilate phosphoribosyltransferase anthranilate[c] + PRPP[c] => diphosphate[c] + N-(5-phospho-beta-D-ribosyl)anthranilate[c] YDR354W Phenylalanine, tyrosine and tryptophan biosynthesis +r_0203 anthranilate synthase chorismate[c] + L-glutamine[c] => anthranilate[c] + H+[c] + L-glutamate[c] + pyruvate[c] YER090W and YKL211C Phenylalanine, tyrosine and tryptophan biosynthesis +r_0204 Ap4A hydrolase H2O[c] + P(1),P(4)-bis(5'-adenosyl) tetraphosphate[c] <=> 2 ADP[c] + 2 H+[c] YDR305C Purine metabolism +r_0205 arabinose reductase H+[c] + L-arabinose[c] + NADPH[c] => L-arabinitol[c] + NADP(+)[c] YHR104W Pentose and glucuronate interconversions +r_0206 arginase H2O[c] + L-arginine[c] => ornithine[c] + urea[c] YPL111W Arginine biosynthesis +r_0207 argininosuccinate lyase (N(omega)-L-arginino)succinic acid[c] <=> fumarate[c] + L-arginine[c] YHR018C Arginine biosynthesis +r_0208 argininosuccinate synthase ATP[c] + L-aspartate[c] + L-citrulline[c] <=> (N(omega)-L-arginino)succinic acid[c] + AMP[c] + diphosphate[c] + H+[c] YOL058W Arginine biosynthesis +r_0209 arginyl-tRNA synthetase ATP[c] + L-arginine[c] + tRNA(Arg)[c] => AMP[c] + Arg-tRNA(Arg)[c] + diphosphate[c] YDR341C tRNA metabolism https://www.yeastgenome.org/go/GO:0006399 +r_0210 arginyl-tRNA synthetase ATP[m] + L-arginine[m] + tRNA(Arg)[m] => AMP[m] + Arg-tRNA(Arg)[m] + diphosphate[m] YHR091C tRNA metabolism https://www.yeastgenome.org/go/GO:0006399 +r_0211 asparagine synthase (glutamine-hydrolysing) ATP[c] + H2O[c] + L-aspartate[c] + L-glutamine[c] => AMP[c] + diphosphate[c] + H+[c] + L-asparagine[c] + L-glutamate[c] YGR124W or YPR145W Alanine, aspartate and glutamate metabolism +r_0212 Asparaginyl-tRNA synthetase ATP[c] + L-asparagine[c] + tRNA(Asn)[c] => AMP[c] + Asn-tRNA(Asn)[c] + diphosphate[c] YHR019C tRNA metabolism https://www.yeastgenome.org/go/GO:0006399 +r_0213 asparaginyl-tRNA synthetase, miotchondrial ATP[m] + L-asparagine[m] + tRNA(Asn)[m] => AMP[m] + Asn-tRNA(Asn)[m] + diphosphate[m] YCR024C tRNA metabolism https://www.yeastgenome.org/go/GO:0006399 +r_0214 aspartate carbamoyltransferase carbamoyl phosphate[c] + L-aspartate[c] => H+[c] + N-carbamoyl-L-aspartate[c] + phosphate[c] YJL130C Pyrimidine metabolism +r_0215 aspartate kinase ATP[c] + L-aspartate[c] => 4-phospho-L-aspartate[c] + ADP[c] YER052C Glycine, serine and threonine metabolism +r_0216 aspartate transaminase 2-oxoglutarate[c] + L-aspartate[c] <=> L-glutamate[c] + oxaloacetate[c] YLR027C Alanine, aspartate and glutamate metabolism +r_0217 aspartate transaminase L-glutamate[m] + oxaloacetate[m] => 2-oxoglutarate[m] + L-aspartate[m] YKL106W Alanine, aspartate and glutamate metabolism +r_0218 aspartate transaminase 2-oxoglutarate[p] + L-aspartate[p] <=> L-glutamate[p] + oxaloacetate[p] YLR027C Alanine, aspartate and glutamate metabolism +r_0219 aspartate-semialdehyde dehydrogenase 4-phospho-L-aspartate[c] + H+[c] + NADPH[c] => L-aspartate 4-semialdehyde[c] + NADP(+)[c] + phosphate[c] YDR158W Glycine, serine and threonine metabolism +r_0220 Aspartyl-tRNA synthetase ATP[c] + L-aspartate[c] + tRNA(Asp)[c] => AMP[c] + Asp-tRNA(Asp)[c] + diphosphate[c] YLL018C tRNA metabolism https://www.yeastgenome.org/go/GO:0006399 +r_0221 Aspartyl-tRNA synthetase ATP[m] + L-aspartate[m] + tRNA(Asp)[m] => AMP[m] + Asp-tRNA(Asp)[m] + diphosphate[m] YPL104W tRNA metabolism https://www.yeastgenome.org/go/GO:0006399 +r_0222 ATP adenylyltransferase ADP[c] + ATP[c] + H+[c] => P(1),P(4)-bis(5'-adenosyl) tetraphosphate[c] + phosphate[c] YDR530C Purine metabolism +r_0223 ATP adenylyltransferase ADP[c] + GTP[c] + H+[c] => P1-(5'-adenosyl),P4-(5'-guanosyl) tetraphosphate[c] + phosphate[c] YCL050C Purine metabolism +r_0224 ATP adenylyltransferase GDP[c] + GTP[c] + H+[c] => P(1),P(4)-bis(5'-guanosyl) tetraphosphate[c] + phosphate[c] YCL050C Purine metabolism +r_0225 ATP phosphoribosyltransferase ATP[c] + PRPP[c] => 5-phosphoribosyl-ATP[c] + diphosphate[c] YER055C Histidine metabolism +r_0226 ATP synthase ADP[m] + 3 H+[c] + phosphate[m] => ATP[m] + 2 H+[m] + H2O[m] (Q0080 and Q0085 and Q0130 and YBL099W and YBR039W and YDL004W and YDR298C and YDR322C-A and YDR377W and YJR121W and YKL016C and YLR295C and YML081C-A and YPL078C and YPL271W) or (Q0080 and Q0085 and Q0130 and YBL099W and YBR039W and YDL004W and YDR298C and YDR377W and YJR121W and YKL016C and YLR295C and YML081C-A and YPL078C and YPL271W and YPR020W) or (Q0080 and Q0085 and Q0130 and YBL099W and YBR039W and YDL004W and YDR298C and YDR322C-A and YDR377W and YJR121W and YKL016C and YLR295C and YML081C-A and YPL078C and YPL271W and YJL180C and YLR393W and YNL315C and YOL077W-A and YCL005W-A) Oxidative phosphorylation +r_0227 ATPase, cytosolic ATP[c] + H2O[c] => ADP[c] + H+[e] + phosphate[c] (YCR024C-A and YEL017C-A and YGL008C) or (YCR024C-A and YEL017C-A and YPL036W) or YER005W Transport [c, e] +r_0228 beta-1,4 mannosyltransferase GDP-alpha-D-mannose[c] + N,N'-diacetylchitobiosyldiphosphodolichol[c] => beta-D-mannosyldiacetylchitobiosyldiphosphodolichol[c] + GDP[c] + H+[c] YBR110W N-glycan biosynthesis +r_0229 biotin synthase dethiobiotin[c] + polysulphur[c] <=> biotin[c] + 2 H+[c] YGR286C Biotin metabolism +r_0230 biotin-[acetyl-CoA-carboxylase] ligase ATP[c] + biotin[c] + H+[c] => biotinyl-5'-AMP[c] + diphosphate[c] YDL141W Biotin metabolism +r_0231 C-14 sterol reductase 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol[c] + H+[c] + NADPH[c] => 14-demethyllanosterol[c] + NADP(+)[c] YNL280C Steroid biosynthesis +r_0233 C-22 sterol desaturase (NADP) ergosta-5,7,24(28)-trien-3beta-ol[c] + H+[c] + NADPH[c] + oxygen[c] => ergosta-5,7,22,24(28)-tetraen-3beta-ol[c] + 2 H2O[c] + NADP(+)[c] YMR015C Steroid biosynthesis +r_0234 C-3 sterol dehydrogenase NADP(+)[c] + zymosterol intermediate 1c[c] => carbon dioxide[c] + NADPH[c] + zymosterol intermediate 2[c] YGL001C Steroid biosynthesis +r_0235 C-3 sterol dehydrogenase (4-methylzymosterol) 4beta-methylzymosterol-4alpha-carboxylic acid[c] + NAD[c] => 3-dehydro-4-methylzymosterol[c] + carbon dioxide[c] + NADH[c] YGL001C Steroid biosynthesis +r_0236 C-3 sterol keto reductase (4-methylzymosterol) 3-dehydro-4-methylzymosterol[c] + H+[c] + NADPH[c] => 4alpha-methylzymosterol[c] + NADP(+)[c] YLR100W Steroid biosynthesis +r_0237 C-3 sterol keto reductase (zymosterol) H+[c] + NADPH[c] + zymosterol intermediate 2[c] => NADP(+)[c] + zymosterol[c] YLR100W Steroid biosynthesis +r_0238 C-4 methyl sterol oxidase 4alpha-methylzymosterol[c] + H+[c] + NADPH[c] + oxygen[c] => H2O[c] + NADP(+)[c] + zymosterol intermediate 1a[c] YGR060W Steroid biosynthesis +r_0239 C-4 methyl sterol oxidase H+[c] + NADPH[c] + oxygen[c] + zymosterol intermediate 1a[c] => 2 H2O[c] + NADP(+)[c] + zymosterol intermediate 1b[c] YGR060W Steroid biosynthesis +r_0240 C-4 methyl sterol oxidase NADPH[c] + oxygen[c] + zymosterol intermediate 1b[c] => H2O[c] + NADP(+)[c] + zymosterol intermediate 1c[c] YGR060W Steroid biosynthesis +r_0241 C-4 sterol methyl oxidase (4,4-dimethylzymosterol) 14-demethyllanosterol[c] + 5 H+[c] + 3 oxygen[c] + 6 Ferrocytochrome b5[erm] => 4beta-methylzymosterol-4alpha-carboxylic acid[c] + 4 H2O[c] + 6 Ferricytochrome b5[erm] YGR060W Steroid biosynthesis +r_0242 C-5 sterol desaturase episterol[c] + H+[c] + NADPH[c] + oxygen[c] => ergosta-5,7,24(28)-trien-3beta-ol[c] + 2 H2O[c] + NADP(+)[c] YLR056W Steroid biosynthesis +r_0243 C-8 sterol isomerase fecosterol[c] => episterol[c] YMR202W Steroid biosynthesis +r_0244 C-s24 sterol reductase ergosta-5,7,22,24(28)-tetraen-3beta-ol[er] + H+[er] + NADPH[er] => ergosterol[er] + NADP(+)[er] YGL012W Steroid biosynthesis +r_0249 CAAX farnesyltransferase 4-hydroxybenzoate[c] + nonaprenyl diphosphate[c] => diphosphate[c] + nonaprenyl 4-hydroxybenzoate[c] YDL090C and YKL019W Terpenoid backbone biosynthesis +r_0250 carbamoyl-phosphate synthase (glutamine-hydrolysing) 2 ATP[c] + bicarbonate[c] + H2O[c] + L-glutamine[c] => 2 ADP[c] + carbamoyl phosphate[c] + 2 H+[c] + L-glutamate[c] + phosphate[c] YJL130C and YJR109C and YOR303W Pyrimidine metabolism +r_0252 carnitine O-acetyltransferase (R)-carnitine[c] + acetyl-CoA[c] => coenzyme A[c] + O-acetylcarnitine[c] YAR035W or YER024W Carnitine metabolism https://www.yeastgenome.org/go/GO:0009437 +r_0253 carnitine O-acetyltransferase (R)-carnitine[p] + acetyl-CoA[p] => coenzyme A[p] + O-acetylcarnitine[p] YML042W Carnitine metabolism https://www.yeastgenome.org/go/GO:0009437 +r_0254 carnitine O-acetyltransferase coenzyme A[m] + O-acetylcarnitine[m] => (R)-carnitine[m] + acetyl-CoA[m] YML042W Carnitine metabolism https://www.yeastgenome.org/go/GO:0009437 +r_0255 catalase 2 hydrogen peroxide[c] => 2 H2O[c] + oxygen[c] YGR088W Glyoxylate and dicarboxylate metabolism +r_0256 catalase 2 hydrogen peroxide[p] => 2 H2O[p] + oxygen[p] YDR256C Glyoxylate and dicarboxylate metabolism +r_0259 ceramide-1 hydroxylase (24C) ceramide-1 (C24)[er] + H+[er] + NADPH[er] + oxygen[er] => ceramide-2 (C24)[er] + H2O[er] + NADP(+)[er] YDR297W Sphingolipid metabolism +r_0260 ceramide-1 hydroxylase (24C) ceramide-1 (C24)[er] + H+[er] + NADPH[er] + oxygen[er] => ceramide-2' (C24)[er] + H2O[er] + NADP(+)[er] YMR272C Sphingolipid metabolism +r_0261 ceramide-1 hydroxylase (26C) ceramide-1 (C26)[er] + H+[er] + NADPH[er] + oxygen[er] => ceramide-2 (C26)[er] + H2O[er] + NADP(+)[er] YDR297W Sphingolipid metabolism +r_0262 ceramide-1 hydroxylase (26C) ceramide-1 (C26)[er] + H+[er] + NADPH[er] + oxygen[er] => ceramide-2' (C26)[er] + H2O[er] + NADP(+)[er] YMR272C Sphingolipid metabolism +r_0263 ceramide-1 synthase (24C) sphinganine[er] + tetracosanoyl-CoA[er] => ceramide-1 (C24)[er] + coenzyme A[er] + H+[er] (YHL003C and YMR298W) or (YKL008C and YMR298W) Sphingolipid metabolism +r_0264 ceramide-1 synthase (26C) hexacosanoyl-CoA[er] + sphinganine[er] => ceramide-1 (C26)[er] + coenzyme A[er] + H+[er] (YHL003C and YMR298W) or (YKL008C and YMR298W) Sphingolipid metabolism +r_0265 ceramide-2 synthase (24C) phytosphingosine[er] + tetracosanoyl-CoA[er] => ceramide-2 (C24)[er] + coenzyme A[er] + H+[er] (YHL003C and YMR298W) or (YKL008C and YMR298W) Sphingolipid metabolism +r_0266 ceramide-2 synthase (26C) hexacosanoyl-CoA[er] + phytosphingosine[er] => ceramide-2 (C26)[er] + coenzyme A[er] + H+[er] (YHL003C and YMR298W) or (YKL008C and YMR298W) Sphingolipid metabolism +r_0267 ceramide-3 synthase (24C) ceramide-2 (C24)[er] + H+[er] + NADPH[er] + oxygen[er] => ceramide-3 (C24)[er] + H2O[er] + NADP(+)[er] YMR272C Sphingolipid metabolism +r_0268 ceramide-3 synthase (26C) ceramide-2 (C26)[er] + H+[er] + NADPH[er] + oxygen[er] => ceramide-3 (C26)[er] + H2O[er] + NADP(+)[er] YMR272C Sphingolipid metabolism +r_0269 ceramide-4 synthase (24C) ceramide-3 (C24)[er] + H+[er] + NADPH[er] + oxygen[er] => ceramide-4 (C24)[er] + H2O[er] + NADP(+)[er] YMR272C Sphingolipid metabolism +r_0270 ceramide-4 synthase (26C) ceramide-3 (C26)[er] + H+[er] + NADPH[er] + oxygen[er] => ceramide-4 (C26)[er] + H2O[er] + NADP(+)[er] YMR272C Sphingolipid metabolism +r_0271 chitin deacetylase chitin[c] + H2O[c] => acetate[c] + chitosan[ce] + H+[c] YLR307W or YLR308W Amino sugar and nucleotide sugar metabolism +r_0272 chitin synthase UDP-N-acetyl-alpha-D-glucosamine[c] => chitin[c] + H+[c] + UDP[c] YBR023C or YBR038W or YNL192W Amino sugar and nucleotide sugar metabolism +r_0273 choline kinase ATP[c] + choline[c] => ADP[c] + choline phosphate[c] + H+[c] YLR133W Glycerophospholipid metabolism +r_0274 choline phosphate cytididyltransferase choline phosphate[c] + CTP[c] + H+[c] => CDP-choline[c] + diphosphate[c] YGR202C Glycerophospholipid metabolism +r_0278 chorismate mutase chorismate[c] => prephenate[c] YPR060C Phenylalanine, tyrosine and tryptophan biosynthesis +r_0279 chorismate synthase 5-O-(1-carboxyvinyl)-3-phosphoshikimic acid[c] => chorismate[c] + phosphate[c] YGL148W Phenylalanine, tyrosine and tryptophan biosynthesis +r_0280 cis-aconitate(3-) to isocitrate cis-aconitate[m] + H2O[m] <=> isocitrate[m] YLR304C Citrate cycle (TCA cycle) +r_0281 cis-prenyltransferase step 01 farnesyl diphosphate[lp] + isopentenyl diphosphate[lp] => diphosphate[lp] + geranylgeranyl diphosphate[lp] YBR002C or YMR101C Terpenoid backbone biosynthesis +r_0282 cis-prenyltransferase step 02 geranylgeranyl diphosphate[lp] + isopentenyl diphosphate[lp] => diphosphate[lp] + pentaprenyl diphosphate[lp] YBR002C or YMR101C Terpenoid backbone biosynthesis +r_0283 cis-prenyltransferase step 03 isopentenyl diphosphate[lp] + pentaprenyl diphosphate[lp] => diphosphate[lp] + hexaprenyl diphosphate[lp] YBR002C or YMR101C Terpenoid backbone biosynthesis +r_0284 cis-prenyltransferase step 04 hexaprenyl diphosphate[lp] + isopentenyl diphosphate[lp] => diphosphate[lp] + heptaprenyl diphosphate[lp] YBR002C or YMR101C Terpenoid backbone biosynthesis +r_0285 cis-prenyltransferase step 05 heptaprenyl diphosphate[lp] + isopentenyl diphosphate[lp] => diphosphate[lp] + octaprenyl diphosphate[lp] YBR002C or YMR101C Terpenoid backbone biosynthesis +r_0286 cis-prenyltransferase step 06 isopentenyl diphosphate[lp] + octaprenyl diphosphate[lp] => diphosphate[lp] + nonaprenyl diphosphate[lp] YBR002C or YMR101C Terpenoid backbone biosynthesis +r_0287 cis-prenyltransferase step 07 isopentenyl diphosphate[lp] + nonaprenyl diphosphate[lp] => decaprenyl diphosphate[lp] + diphosphate[lp] YBR002C or YMR101C Terpenoid backbone biosynthesis +r_0288 cis-prenyltransferase step 08 decaprenyl diphosphate[lp] + isopentenyl diphosphate[lp] => diphosphate[lp] + undecaprenyl diphosphate[lp] YBR002C or YMR101C Terpenoid backbone biosynthesis +r_0289 cis-prenyltransferase step 09 isopentenyl diphosphate[lp] + undecaprenyl diphosphate[lp] => diphosphate[lp] + dodecaprenyl diphosphate[lp] YBR002C or YMR101C Terpenoid backbone biosynthesis +r_0290 cis-prenyltransferase step 10 dodecaprenyl diphosphate[lp] + isopentenyl diphosphate[lp] => diphosphate[lp] + tridecaprenyl diphosphate[lp] YBR002C or YMR101C Terpenoid backbone biosynthesis +r_0291 cis-prenyltransferase step 11 isopentenyl diphosphate[lp] + tridecaprenyl diphosphate[lp] => diphosphate[lp] + tetradecaprenyl diphosphate[lp] YBR002C or YMR101C Terpenoid backbone biosynthesis +r_0292 cis-prenyltransferase step 12 isopentenyl diphosphate[lp] + tetradecaprenyl diphosphate[lp] => diphosphate[lp] + pentadecaprenyl diphosphate[lp] YBR002C or YMR101C Terpenoid backbone biosynthesis +r_0293 cis-prenyltransferase step 13 isopentenyl diphosphate[lp] + pentadecaprenyl diphosphate[lp] => diphosphate[lp] + hexadecaprenyl diphosphate[lp] YBR002C or YMR101C Terpenoid backbone biosynthesis +r_0294 cis-prenyltransferase step 14 hexadecaprenyl diphosphate[lp] + isopentenyl diphosphate[lp] <=> diphosphate[lp] + heptadecaprenyl diphosphate[lp] YBR002C or YMR101C Terpenoid backbone biosynthesis +r_0295 cis-prenyltransferase step 15 heptadecaprenyl diphosphate[lp] + isopentenyl diphosphate[lp] <=> diphosphate[lp] + octadecaprenyl diphosphate[lp] YBR002C or YMR101C Terpenoid backbone biosynthesis +r_0296 cis-prenyltransferase step 16 isopentenyl diphosphate[lp] + octadecaprenyl diphosphate[lp] => diphosphate[lp] + nonadecaprenyl diphosphate[lp] YBR002C or YMR101C Terpenoid backbone biosynthesis +r_0297 cis-prenyltransferase step 17 isopentenyl diphosphate[lp] + nonadecaprenyl diphosphate[lp] => diphosphate[lp] + icosaprenyl diphosphate[lp] YBR002C or YMR101C Terpenoid backbone biosynthesis +r_0298 cis-prenyltransferase step 18 icosaprenyl diphosphate[lp] + isopentenyl diphosphate[lp] => diphosphate[lp] + henicosaprenyl diphosphate[lp] YBR002C or YMR101C Terpenoid backbone biosynthesis +r_0299 cis-prenyltransferase step 19 henicosaprenyl diphosphate[lp] + isopentenyl diphosphate[lp] => diphosphate[lp] + docosaprenyl diphosphate[lp] YBR002C or YMR101C Terpenoid backbone biosynthesis +r_0300 citrate synthase acetyl-CoA[m] + H2O[m] + oxaloacetate[m] => citrate[m] + coenzyme A[m] + H+[m] YNR001C or YPR001W Citrate cycle (TCA cycle) +r_0301 citrate synthase, peroxisomal acetyl-CoA[p] + H2O[p] + oxaloacetate[p] => citrate[p] + coenzyme A[p] + H+[p] YCR005C Citrate cycle (TCA cycle) +r_0302 citrate to cis-aconitate(3-) citrate[m] <=> cis-aconitate[m] + H2O[m] YLR304C Citrate cycle (TCA cycle) +r_0303 citrate to cis-aconitate(3-), cytoplasmic citrate[c] <=> cis-aconitate[c] + H2O[c] YLR304C Citrate cycle (TCA cycle) +r_0304 coproporphyrinogen oxidase (O2 required) coproporphyrinogen III[c] + 2 H+[c] + oxygen[c] => 2 carbon dioxide[c] + 2 H2O[c] + protoporphyrinogen[c] YDR044W Porphyrin and chlorophyll metabolism +r_0306 CTP synthase (glutamine) ATP[c] + H2O[c] + L-glutamine[c] + UTP[c] => ADP[c] + CTP[c] + 2 H+[c] + L-glutamate[c] + phosphate[c] YBL039C or YJR103W Pyrimidine metabolism +r_0307 CTP synthase (NH3) ammonium[c] + ATP[c] + UTP[c] => ADP[c] + CTP[c] + 2 H+[c] + phosphate[c] YBL039C or YJR103W Pyrimidine metabolism +r_0308 cystathionine b-lyase H2O[c] + L-cystathionine[c] => ammonium[c] + L-homocysteine[c] + pyruvate[c] YFR055W or YGL184C Cysteine and methionine metabolism +r_0309 cystathionine beta-synthase L-homocysteine[c] + L-serine[c] => H2O[c] + L-cystathionine[c] YGR155W Glycine, serine and threonine metabolism +r_0310 cystathionine g-lyase H2O[c] + L-cystathionine[c] => 2-oxobutanoate[c] + ammonium[c] + L-cysteine[c] YAL012W Cysteine and methionine metabolism +r_0311 cystathionine gamma-synthase L-cysteine[c] + O-acetyl-L-homoserine[c] => acetate[c] + H+[c] + L-cystathionine[c] YJR130C Cysteine and methionine metabolism +r_0312 cysteine synthase hydrogen sulfide[c] + O-acetyl-L-serine[c] => acetate[c] + L-cysteine[c] YLR303W Cysteine and methionine metabolism +r_0313 cysteinyl-tRNA synthetase ATP[c] + L-cysteine[c] + tRNA(Cys)[c] => AMP[c] + Cys-tRNA(Cys)[c] + diphosphate[c] YNL247W tRNA metabolism https://www.yeastgenome.org/go/GO:0006399 +r_0314 cytidine deaminase cytidine[c] + H+[c] + H2O[c] => ammonium[c] + uridine[c] YLR245C Pyrimidine metabolism +r_0315 cytidine kinase (GTP) cytidine[c] + GTP[c] => CMP[c] + GDP[c] + H+[c] YNR012W Pyrimidine metabolism +r_0317 cytochrome P450 lanosterol 14-alpha-demethylase (NADP) 2 H+[c] + lanosterol[c] + 3 NADPH[c] + 3 oxygen[c] => 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol[c] + formate[c] + 4 H2O[c] + 3 NADP(+)[c] YHR007C and YHR042W Steroid biosynthesis +r_0318 cytosine deaminase cytosine[c] + H+[c] + H2O[c] => ammonium[c] + uracil[c] YPR062W Pyrimidine metabolism +r_0319 D-arabinono-1,4-lactone oxidase D-arabinono-1,4-lactone[c] + oxygen[c] => dehydro-D-arabinono-1,4-lactone[c] + H+[c] + hydrogen peroxide[c] YML086C Alternate carbon metabolism +r_0320 D-arabinose 1-dehydrogenase (NAD) D-arabinose[c] + NAD[c] => D-arabinono-1,4-lactone[c] + H+[c] + NADH[c] YMR041C Alternate carbon metabolism +r_0321 D-arabinose 1-dehydrogenase (NADP) D-arabinose[c] + NADP(+)[c] => D-arabinono-1,4-lactone[c] + H+[c] + NADPH[c] YBR149W Alternate carbon metabolism +r_0322 D-fructose 1-phosphate D-glyceraldehyde-3-phosphate-lyase D-fructose 1-phosphate[c] <=> D-glyceraldehyde[c] + dihydroxyacetone phosphate[c] YKL060C Glycolysis / gluconeogenesis +r_0323 D-sorbitol dehydrogenase (D-fructose producing) D-glucitol[c] + NAD[c] => D-fructose[c] + H+[c] + NADH[c] YDL246C or YJR159W Fructose and mannose metabolism +r_0326 dCMP deaminase dCMP[c] + H+[c] + H2O[c] <=> ammonium[c] + dUMP[c] YHR144C Pyrimidine metabolism +r_0327 dCTP deaminase dCTP[c] + H+[c] + H2O[c] => ammonium[c] + dUTP[c] YHR144C Pyrimidine metabolism +r_0328 deoxyadenosine deaminase 2'-deoxyadenosine[c] + H+[c] + H2O[c] => 2'-deoxyinosine[c] + ammonium[c] YNL141W Purine metabolism +r_0329 deoxycytidine deaminase deoxycytidine[c] + H+[c] + H2O[c] => 2'-deoxyuridine[c] + ammonium[c] YLR245C Pyrimidine metabolism +r_0330 deoxyguanylate kinase (dGMP:ATP) ATP[c] + dGMP[c] <=> ADP[c] + dGDP[c] YDR454C Purine metabolism +r_0331 deoxyhypusine synthase, cytosolic/mitochondrial H2O[c] + spermidine[c] + ubiquinone-6[m] => 4-aminobutanal[c] + trimethylenediamine[c] + ubiquinol-6[m] YHR068W Arginine and proline metabolism Spermidine and 4-aminobutanal are in Arg and Pro metabolism +r_0332 deoxyribokinase 2-deoxy-D-ribose[c] + ATP[c] => 2-deoxy-D-ribose 5-phosphate[c] + ADP[c] + H+[c] YCR036W Pentose phosphate pathway +r_0334 dephospho-CoA kinase 3'-dephospho-CoA[m] + ATP[m] => ADP[m] + coenzyme A[m] + H+[m] YDR196C Pantothenate and coa biosynthesis +r_0335 dethiobiotin synthase 7,8-diaminononanoate[c] + ATP[c] + carbon dioxide[c] <=> ADP[c] + dethiobiotin[c] + 3 H+[c] + phosphate[c] YNR057C Biotin metabolism +r_0340 dihydroceramidase lignoceric acid[er] + sphinganine[er] <=> ceramide-1 (C24)[er] + H2O[er] YPL087W Sphingolipid metabolism +r_0341 dihydroceramidase cerotic acid[er] + sphinganine[er] <=> ceramide-1 (C26)[er] + H2O[er] YPL087W Sphingolipid metabolism +r_0342 dihydroceramidase ceramide-2 (C24)[er] + H2O[er] => lignoceric acid[er] + phytosphingosine[er] YPL087W Sphingolipid metabolism +r_0343 dihydroceramidase ceramide-2 (C26)[er] + H2O[er] => cerotic acid[er] + phytosphingosine[er] YPL087W Sphingolipid metabolism +r_0344 dihydrofolate reductase dihydrofolic acid[c] + H+[c] + NADPH[c] => NADP(+)[c] + THF[c] YOR236W Folate biosynthesis +r_0345 dihydrofolate reductase dihydrofolic acid[m] + H+[m] + NADPH[m] => NADP(+)[m] + THF[m] YOR236W Folate biosynthesis +r_0346 dihydrofolate synthase 7,8-dihydropteroate[c] + ATP[c] + L-glutamate[c] => ADP[c] + dihydrofolic acid[c] + H+[c] + phosphate[c] YMR113W Folate biosynthesis +r_0347 dihydroneopterin aldolase 7,8-dihydroneopterin[m] => 2-amino-6-(hydroxymethyl)-7,8-dihydropteridin-4-ol[m] + glycolaldehyde[m] YNL256W Folate biosynthesis +r_0348 dihydroneopterin monophosphate dephosphorylase 7,8-dihydroneopterin 3'-phosphate[c] + H2O[c] => 7,8-dihydroneopterin[c] + phosphate[c] YDL100C Folate biosynthesis +r_0349 dihydroorotase (S)-dihydroorotate[c] + H2O[c] <=> H+[c] + N-carbamoyl-L-aspartate[c] YLR420W Pyrimidine metabolism +r_0350 dihydropteroate synthase 2-amino-6-(hydroxymethyl)-7,8-dihydropteridin-4-ol[m] + 4-aminobenzoate[m] => 7,8-dihydropteroate[m] + H2O[m] YNL256W Folate biosynthesis +r_0351 dihydropteroate synthase (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl trihydrogen diphosphate[m] + 4-aminobenzoate[m] => 7,8-dihydropteroate[m] + diphosphate[m] YNL256W Folate biosynthesis +r_0352 dihydroxy-acid dehydratase (2,3-dihydroxy-3-methylbutanoate) (R)-2,3-dihydroxy-3-methylbutanoate[m] => 3-methyl-2-oxobutanoate[m] + H2O[m] YJR016C Valine, leucine and isoleucine metabolism +r_0353 dihydroxy-acid dehydratase (2,3-dihydroxy-3-methylpentanoate) (2R,3R)-2,3-dihydroxy-3-methylpentanoate[m] => (S)-3-methyl-2-oxopentanoate[m] + H2O[m] YJR016C Valine, leucine and isoleucine metabolism +r_0354 dihydroxyacetone kinase ATP[c] + glycerone[c] => ADP[c] + dihydroxyacetone phosphate[c] + H+[c] YFL053W or YML070W Glycerolipid metabolism +r_0355 dimethylallyltranstransferase isopentenyl diphosphate[c] + prenyl diphosphate(3-)[c] => diphosphate[c] + geranyl diphosphate[c] YJL167W Terpenoid backbone biosynthesis +r_0356 diphosphoglyceromutase 1,3-bisphospho-D-glycerate[c] <=> 2,3-bisphospho-D-glyceric acid[c] + H+[c] YKL152C Glycolysis / gluconeogenesis +r_0357 diphosphoinositol-1,3,4,6-tetrakisphosphate diphosphohydrolase 5,6-bis(diphospho)-1D-myo-inositol tetrakisphosphate[c] + 3 H2O[c] => 3 H+[c] + myo-inositol 1,3,4,5,6-pentakisphosphate[c] + 3 phosphate[c] YOR163W Inositol phosphate metabolism +r_0358 diphosphoinositol-1,3,4,6-tetrakisphosphate synthase ATP[c] + 2 H+[c] + myo-inositol 1,3,4,5,6-pentakisphosphate[c] + 2 phosphate[c] => 5,6-bis(diphospho)-1D-myo-inositol tetrakisphosphate[c] + ADP[c] + 2 H2O[c] YDR017C Phosphatidylinositol signaling system +r_0359 diphthine synthase 2-(3-amino-3-carboxypropyl)-L-histidine[c] + S-adenosyl-L-methionine[c] => 2-[3-carboxy-3-(methylammonio)propyl]-L-histidine[c] + H+[c] + S-adenosyl-L-homocysteine[c] YLR172C Cysteine and methionine metabolism +r_0360 dolichol kinase CTP[c] + dolichol[c] + H+[c] => CDP[c] + dolichyl phosphate[c] YMR013C N-glycan biosynthesis +r_0361 dolichyl-phosphate D-mannosyltransferase dolichyl phosphate[c] + GDP-alpha-D-mannose[c] => dolichyl D-mannosyl phosphate[er] + GDP[c] + H+[c] YPR183W N-glycan biosynthesis +r_0362 dolichyl-phosphate-mannose--protein mannosyltransferase dolichyl D-mannosyl phosphate[er] => dolichyl phosphate[er] + mannan[er] (YAL023C and YDL095W) or YDL093W or YJR143C or YOR321W N-glycan biosynthesis +r_0363 dTMP kinase ATP[c] + dTMP[c] => ADP[c] + dTDP[c] YJR057W Pyrimidine metabolism +r_0364 dUTP diphosphatase dUTP[c] + H2O[c] => diphosphate[c] + dUMP[c] + H+[c] YJR069C or YBR252W Pyrimidine metabolism +r_0365 endopolygalacturonase H2O[e] + pectin[e] => D-galacturonate[e] YJR153W Pentose and glucuronate interconversions +r_0366 enolase 2-phospho-D-glyceric acid[c] <=> H2O[c] + phosphoenolpyruvate[c] YPL281C or YGR254W or YHR174W or YMR323W or YOR393W Glycolysis / gluconeogenesis +r_0368 ethanolamine kinase ATP[c] + ethanolamine[c] => ADP[c] + H+[c] + O-phosphoethanolamine[c] YDR147W or YLR133W Glycerophospholipid metabolism +r_0369 ethyl acetate-hydrolyzing esterase ethyl acetate[c] + H2O[c] => acetate[c] + ethanol[c] + H+[c] YOR126C Complex alcohol metabolism +r_0370 exo-1,3-beta-glucan glucohydrase (1->3)-beta-D-glucan[e] + H2O[e] => D-glucose[e] YDR261C or YGR282C or YLR300W or YNR067C or YOR190W Starch and sucrose metabolism +r_0373 farnesyltranstransferase farnesyl diphosphate[c] + isopentenyl diphosphate[c] => geranylgeranyl diphosphate[c] + diphosphate[c] YPL069C Terpenoid backbone biosynthesis +r_0399 fatty-acid--CoA ligase (decanoate) ATP[p] + coenzyme A[p] + decanoate[p] <=> AMP[p] + decanoyl-CoA[p] + diphosphate[p] YER015W Fatty acid biosynthesis +r_0400 fatty-acid--CoA ligase (dodecanoate) ATP[p] + coenzyme A[p] + laurate[p] <=> AMP[p] + diphosphate[p] + lauroyl-CoA[p] YER015W Fatty acid biosynthesis +r_0402 fatty-acid--CoA ligase (hexadecanoate) ATP[p] + coenzyme A[p] + palmitate[p] <=> AMP[p] + diphosphate[p] + palmitoyl-CoA[p] YER015W Fatty acid biosynthesis +r_0410 fatty-acid--CoA ligase (octanoate) ATP[p] + coenzyme A[p] + octanoate[p] <=> AMP[p] + diphosphate[p] + octanoyl-CoA[p] YER015W Fatty acid biosynthesis +r_0412 fatty-acid--CoA ligase (tetradecanoate) ATP[p] + coenzyme A[p] + myristate[p] <=> AMP[p] + diphosphate[p] + myristoyl-CoA[p] YER015W Fatty acid biosynthesis +r_0436 ferrochelatase iron(2+)[m] + protoporphyrin[m] => ferroheme b[m] + 2 H+[m] YOR176W Porphyrin and chlorophyll metabolism +r_0437 ferrocytochrome-c:hydrogen-peroxide oxidoreductase 2 ferrocytochrome c[m] + hydrogen peroxide[m] => 2 ferricytochrome c[m] + 2 H2O[m] (YEL039C and YKR066C) or (YJR048W and YKR066C) Oxidative phosphorylation +r_0438 ferrocytochrome-c:oxygen oxidoreductase ferrocytochrome c[m] + 1.266 H+[m] + 0.25 oxygen[m] => ferricytochrome c[m] + 0.633 H+[c] + 0.5 H2O[m] (Q0045 and Q0250 and Q0275 and YDL067C and YEL039C and YGL187C and YGL191W and YHR051W and YIL111W and YLR038C and YLR395C and YMR256C) or (Q0045 and Q0250 and Q0275 and YDL067C and YEL039C and YGL187C and YGL191W and YHR051W and YLR038C and YLR395C and YMR256C and YNL052W) or (Q0045 and Q0250 and Q0275 and YDL067C and YGL187C and YGL191W and YHR051W and YIL111W and YJR048W and YLR038C and YLR395C and YMR256C) or (Q0045 and Q0250 and Q0275 and YDL067C and YGL187C and YGL191W and YHR051W and YJR048W and YLR038C and YLR395C and YMR256C and YNL052W) or (Q0045 and Q0250 and Q0275 and YDL067C and YHR116W and YDR231C and YGR062C and YJL003W and YPL132W and YLL018C-A) Oxidative phosphorylation +r_0439 ubiquinol:ferricytochrome c reductase 2 ferricytochrome c[m] + 1.266 H+[m] + ubiquinol-6[m] => 2 ferrocytochrome c[m] + 2.532 H+[c] + ubiquinone-6[m] (Q0105 and YBL045C and YDR529C and YEL024W and YEL039C and YFR033C and YGR183C and YHR001W-A and YJL166W and YOR065W and YPR191W) or (Q0105 and YBL045C and YDR529C and YEL024W and YFR033C and YGR183C and YHR001W-A and YJL166W and YJR048W and YOR065W and YPR191W) Oxidative phosphorylation +r_0440 FMN adenylyltransferase ATP[c] + FMN[c] + H+[c] => diphosphate[c] + FAD[c] YDL045C Riboflavin metabolism +r_0441 FMN reductase FMN[c] + 2 H+[c] + NADH[c] => FMNH2[c] + NAD[c] YLR011W Riboflavin metabolism +r_0442 FMN reductase FMN[c] + 2 H+[c] + NADPH[c] => FMNH2[c] + NADP(+)[c] YLR011W Riboflavin metabolism +r_0443 formaldehyde dehydrogenase formaldehyde[c] + glutathione[c] + NAD[c] => H+[c] + NADH[c] + S-formylglutathione[c] YDL168W Tyrosine metabolism +r_0445 formate dehydrogenase formate[c] + NAD[c] => carbon dioxide[c] + NADH[c] YOR388C Glyoxylate and dicarboxylate metabolism +r_0446 formate-tetrahydrofolate ligase ATP[c] + formate[c] + THF[c] <=> 10-formyl-THF[c] + ADP[c] + phosphate[c] YGR204W One carbon pool by folate +r_0447 formate-tetrahydrofolate ligase ATP[m] + formate[m] + THF[m] <=> 10-formyl-THF[m] + ADP[m] + phosphate[m] YBR084W One carbon pool by folate +r_0448 fructose-2,6-bisphosphate 2-phosphatase beta-D-fructose 2,6-bisphosphate[c] + H2O[c] => D-fructose 6-phosphate[c] + phosphate[c] YLR345W or YJL155C Fructose and mannose metabolism +r_0449 fructose-bisphosphatase D-fructose 1,6-bisphosphate[c] + H2O[c] => D-fructose 6-phosphate[c] + phosphate[c] YLR377C Glycolysis / gluconeogenesis +r_0450 fructose-bisphosphate aldolase D-fructose 1,6-bisphosphate[c] <=> dihydroxyacetone phosphate[c] + glyceraldehyde 3-phosphate[c] YKL060C Glycolysis / gluconeogenesis +r_0451 fumarase fumarate[m] + H2O[m] <=> (S)-malate[m] YPL262W Citrate cycle (TCA cycle) +r_0452 fumarase, cytoplasmic fumarate[c] + H2O[c] <=> (S)-malate[c] YPL262W Citrate cycle (TCA cycle) +r_0453 dihydoorotic acid dehydrogenase (S)-dihydroorotate[c] + fumarate[c] => orotate[c] + succinate[c] YKL216W Pyrimidine metabolism +r_0454 fumarate reductase FADH2[m] + fumarate[m] <=> FAD[m] + H+[m] + succinate[m] YEL047C Citrate cycle (TCA cycle) +r_0455 soluble fumarate reductase FADH2[c] + fumarate[c] <=> FAD[c] + H+[c] + succinate[c] YEL047C Cellular response to anaerobic conditions https://www.yeastgenome.org/go/GO:0071454 +r_0457 g-glutamyltransferase glutathione[c] + L-alanine[c] => L-cysteinylglycine[c] + L-gamma-glutamyl-L-alanine[c] YLR299W Glutathione metabolism +r_0458 galactokinase ATP[c] + D-galactose[c] => ADP[c] + alpha-D-galactose 1-phosphate[c] + H+[c] YBR020W Galactose metabolism +r_0459 galactose-1-phosphate uridylyltransferase alpha-D-galactose 1-phosphate[c] + H+[c] + UTP[c] => diphosphate[c] + UDP-D-galactose[c] YBR018C Galactose metabolism +r_0460 gamma-glutamylcysteine synthetase ATP[c] + L-cysteine[c] + L-glutamate[c] => ADP[c] + H+[c] + L-gamma-glutamyl-L-cysteine[c] + phosphate[c] YJL101C Glutathione metabolism +r_0461 geranylgeranyltranstransferase geranylgeranyl diphosphate[c] + isopentenyl diphosphate[c] => diphosphate[c] + pentaprenyl diphosphate[c] Ubiquinone and other terpenoid-quinone biosynthesis +r_0462 geranyltranstransferase geranyl diphosphate[c] + isopentenyl diphosphate[c] => farnesyl diphosphate[c] + diphosphate[c] YJL167W Terpenoid backbone biosynthesis +r_0463 glucan 1,4-alpha-glucosidase glycogen[c] + H2O[c] => D-glucose[c] YPR184W Starch and sucrose metabolism +r_0464 glucan 1,4-alpha-glucosidase, vacuole glycogen[v] + H2O[v] => D-glucose[v] YIL099W Starch and sucrose metabolism +r_0465 glucosamine-6-phosphate deaminase alpha-D-glucosamine 6-phosphate[c] + H2O[c] => ammonium[c] + D-fructose 6-phosphate[c] Amino sugar and nucleotide sugar metabolism +r_0466 glucose 6-phosphate dehydrogenase D-glucose 6-phosphate[c] + NADP(+)[c] => 6-O-phosphono-D-glucono-1,5-lactone[c] + H+[c] + NADPH[c] YNL241C Pentose phosphate pathway +r_0467 glucose-6-phosphate isomerase D-glucose 6-phosphate[c] <=> D-fructose 6-phosphate[c] YBR196C Glycolysis / gluconeogenesis +r_0468 glutamate 5-kinase ATP[c] + L-glutamate[c] => ADP[c] + L-gamma-glutamyl phosphate[c] YDR300C Arginine and proline metabolism +r_0469 glutamate decarboxylase H+[c] + L-glutamate[c] => carbon dioxide[c] + gamma-aminobutyrate[c] YMR250W Alanine, aspartate and glutamate metabolism +r_0470 glutamate dehydrogenase (NAD) H2O[c] + L-glutamate[c] + NAD[c] => 2-oxoglutarate[c] + ammonium[c] + H+[c] + NADH[c] YDL215C Alanine, aspartate and glutamate metabolism +r_0471 glutamate dehydrogenase (NADP) 2-oxoglutarate[c] + ammonium[c] + H+[c] + NADPH[c] => H2O[c] + L-glutamate[c] + NADP(+)[c] YAL062W or YOR375C Alanine, aspartate and glutamate metabolism +r_0472 glutamate synthase (NADH2) 2-oxoglutarate[c] + H+[c] + L-glutamine[c] + NADH[c] => 2 L-glutamate[c] + NAD[c] YDL171C Alanine, aspartate and glutamate metabolism +r_0473 glutamate-5-semialdehyde dehydrogenase H+[c] + L-gamma-glutamyl phosphate[c] + NADPH[c] => L-glutamic 5-semialdehyde[c] + NADP(+)[c] + phosphate[c] YOR323C Arginine and proline metabolism +r_0475 glutaminase H2O[c] + L-glutamine[c] => ammonium[c] + L-glutamate[c] YFL060C or YNL334C Alanine, aspartate and glutamate metabolism +r_0476 glutamine synthetase ammonium[c] + ATP[c] + L-glutamate[c] => ADP[c] + H+[c] + L-glutamine[c] + phosphate[c] YPR035W Alanine, aspartate and glutamate metabolism +r_0477 glutamine-fructose-6-phosphate transaminase D-fructose 6-phosphate[c] + L-glutamine[c] => alpha-D-glucosamine 6-phosphate[c] + L-glutamate[c] YMR084W or YKL104C Alanine, aspartate and glutamate metabolism +r_0478 glutaminyl-tRNA synthetase ATP[c] + L-glutamine[c] + tRNA(Gln)[c] => AMP[c] + diphosphate[c] + Gln-tRNA(Gln)[c] YOR168W tRNA metabolism https://www.yeastgenome.org/go/GO:0006399 +r_0479 glutamyl-tRNA synthetase ATP[c] + L-glutamate[c] + tRNA(Glu)[c] => AMP[c] + diphosphate[c] + Glu-tRNA(Glu)[c] YGL245W tRNA metabolism https://www.yeastgenome.org/go/GO:0006399 +r_0480 glutamyl-tRNA synthetase ATP[m] + L-glutamate[m] + tRNA(Glu)[m] => AMP[m] + diphosphate[m] + Glu-tRNA(Glu)[m] YOL033W tRNA metabolism https://www.yeastgenome.org/go/GO:0006399 +r_0481 glutathione oxidoreductase glutathione disulfide[c] + H+[c] + NADPH[c] => 2 glutathione[c] + NADP(+)[c] (YCL035C and YPL091W) or (YDR098C and YPL091W) or (YDR513W and YPL091W) or (YER174C and YPL091W) Glutathione metabolism +r_0482 glutathione oxidoreductase glutathione disulfide[m] + H+[m] + NADPH[m] => 2 glutathione[m] + NADP(+)[m] YPL059W and YPL091W Glutathione metabolism +r_0483 glutathione peridoxase 2 glutathione[c] + hydrogen peroxide[c] => glutathione disulfide[c] + 2 H2O[c] YNL229C or YBR244W or YCL035C or YDR513W or YIR037W or YKL026C Glutathione metabolism +r_0484 glutathione peroxidase, mitochondria 2 glutathione[m] + hydrogen peroxide[m] => glutathione disulfide[m] + 2 H2O[m] YPL059W Glutathione metabolism +r_0485 glutathione synthetase ATP[c] + L-gamma-glutamyl-L-cysteine[c] + L-glycine[c] => ADP[c] + glutathione[c] + H+[c] + phosphate[c] YOL049W Glutathione metabolism +r_0486 glyceraldehyde-3-phosphate dehydrogenase glyceraldehyde 3-phosphate[c] + NAD[c] + phosphate[c] <=> 1,3-bisphospho-D-glycerate[c] + H+[c] + NADH[c] YGR192C or YJL052W or YJR009C Glycolysis / gluconeogenesis +r_0487 glycerol dehydrogenase (NADP-dependent) glycerol[c] + NADP(+)[c] => glycerone[c] + H+[c] + NADPH[c] YOR120W Glycerolipid metabolism +r_0488 glycerol kinase ATP[c] + glycerol[c] => ADP[c] + glycerol 3-phosphate[c] + H+[c] YHL032C Glycerolipid metabolism +r_0489 glycerol-3-phosphatase glycerol 3-phosphate[c] + H2O[c] => glycerol[c] + phosphate[c] YER062C or YIL053W Glycerolipid metabolism +r_0490 glycerol-3-phosphate dehydrogenase (fad) FAD[m] + glycerol 3-phosphate[m] + H+[m] => dihydroxyacetone phosphate[m] + FADH2[m] YIL155C Glycerophospholipid metabolism +r_0491 glycerol-3-phosphate dehydrogenase (NAD) dihydroxyacetone phosphate[c] + H+[c] + NADH[c] => glycerol 3-phosphate[c] + NAD[c] YDL022W or YOL059W Glycerophospholipid metabolism +r_0492 glycerol-3-phosphate dehydrogenase (NAD) dihydroxyacetone phosphate[m] + H+[m] + NADH[m] => glycerol 3-phosphate[m] + NAD[m] YOL059W Glycerophospholipid metabolism +r_0497 glycerophosphodiester phosphodiesterase (glycerophosphocholine) H2O[c] + sn-glycero-3-phosphocholine[c] => choline[c] + glycerol 3-phosphate[c] + H+[c] YPL110C Glycerophospholipid metabolism +r_0499 glycinamide ribotide transformylase 10-formyl-THF[c] + 5-phospho-ribosyl-glycineamide[c] => 5'-phosphoribosyl-N-formylglycineamide[c] + H+[c] + THF[c] YDR408C Purine metabolism +r_0500 glycine C-acetyltransferase coenzyme A[c] + L-2-amino-3-oxobutanoate[c] => acetyl-CoA[c] + L-glycine[c] Glycine, serine and threonine metabolism +r_0501 glycine cleavage system L-glycine[m] + NAD[m] + THF[m] => 5,10-methylenetetrahydrofolate[m] + ammonium[m] + carbon dioxide[m] + NADH[m] YAL044C and YDR019C and YFL018C and YMR189W Glycine, serine and threonine metabolism +r_0502 glycine hydroxymethyltransferase L-serine[c] + THF[c] <=> 5,10-methylenetetrahydrofolate[c] + H2O[c] + L-glycine[c] YLR058C Glycine, serine and threonine metabolism +r_0503 glycine hydroxymethyltransferase L-serine[m] + THF[m] <=> 5,10-methylenetetrahydrofolate[m] + H2O[m] + L-glycine[m] YBR263W Glycine, serine and threonine metabolism +r_0504 glycine-cleavage complex (lipoamide) H+[m] + L-glycine[m] + lipoamide[m] => carbon dioxide[m] + S(8)-aminomethyldihydrolipoamide[m] YAL044C and YDR019C and YFL018C and YMR189W Glycine, serine and threonine metabolism +r_0505 glycine-cleavage complex (lipoamide) dihydrolipoamide[m] + NAD[m] => H+[m] + lipoamide[m] + NADH[m] (YAL044C and YDR019C and YFL018C and YMR189W) or (YDR148C and YFL018C and YIL125W) Glycine, serine and threonine metabolism +r_0506 glycine-cleavage complex (lipoylprotein) L-glycine[m] + lipoylprotein[m] => carbon dioxide[m] + S(8)-aminomethyldihydrolipoylprotein[m] YAL044C and YDR019C and YFL018C and YMR189W Glycine, serine and threonine metabolism +r_0507 glycine-cleavage complex (lipoylprotein) H+[m] + S(8)-aminomethyldihydrolipoylprotein[m] + THF[m] => 5,10-methylenetetrahydrofolate[m] + ammonium[m] + dihydrolipoylprotein[m] YAL044C and YDR019C and YFL018C and YMR189W Glycine, serine and threonine metabolism +r_0508 glycine-cleavage complex (lipoylprotein) dihydrolipoylprotein[m] + NAD[m] => H+[m] + lipoylprotein[m] + NADH[m] YAL044C and YDR019C and YFL018C and YMR189W Glycine, serine and threonine metabolism +r_0509 glycine-cleavage system (lipoamide) S(8)-aminomethyldihydrolipoamide[m] + THF[m] => 5,10-methylenetetrahydrofolate[m] + ammonium[m] + dihydrolipoamide[m] YAL044C and YDR019C and YFL018C and YMR189W Glycine, serine and threonine metabolism +r_0510 glycogen (starch) synthase UDP-D-glucose[c] => glycogen[c] + H+[c] + UDP[c] (YFR015C and YJL137C) or (YFR015C and YKR058W) or (YJL137C and YLR258W) or (YKR058W and YLR258W) Starch and sucrose metabolism +r_0511 glycogen phosphorylase glycogen[c] + phosphate[c] => D-glucose 1-phosphate[c] YPR160W Starch and sucrose metabolism +r_0512 glycyl-tRNA synthetase ATP[c] + L-glycine[c] + tRNA(Gly)[c] => AMP[c] + diphosphate[c] + Gly-tRNA(Gly)[c] YBR121C or YPR081C tRNA metabolism https://www.yeastgenome.org/go/GO:0006399 +r_0514 GMP synthase ATP[c] + H2O[c] + L-glutamine[c] + xanthosine-5-phosphate[c] => AMP[c] + diphosphate[c] + GMP[c] + 2 H+[c] + L-glutamate[c] YMR217W Purine metabolism +r_0518 GPI-anchor assembly, step 2 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol[er] + H2O[er] <=> 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol[er] + acetate[er] + H+[er] YMR281W Glycosylphosphatidylinositol (gpi)-anchor biosynthesis +r_0519 GPI-anchor assembly, step 5 6-(alpha-D-glucosaminyl)-O-acyl-1-phosphatidyl-1D-myo-inositol[er] + dolichyl D-mannosyl phosphate[er] <=> 6-O-[alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-O-acyl-1-phosphatidyl-1D-myo-inositol[er] + dolichyl phosphate[er] YCL052C and YJR013W Glycosylphosphatidylinositol (gpi)-anchor biosynthesis +r_0520 GPI-anchor assembly, step 6 6-O-[alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-O-acyl-1-phosphatidyl-1D-myo-inositol[er] + phosphatidylethanolamine backbone[er] <=> 6-O-{2-O-[(2-aminoethyl)phosphoryl]-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl}-O-acyl-1-phosphatidyl-1D-myo-inositol[er] YKL165C Glycosylphosphatidylinositol (gpi)-anchor biosynthesis +r_0521 GPI-anchor assembly, step 7 6-O-{2-O-[(2-aminoethyl)phosphoryl]-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl}-O-acyl-1-phosphatidyl-1D-myo-inositol[er] + dolichyl D-mannosyl phosphate[er] <=> 6-O-{alpha-D-mannosyl-(1->6)-2-O-[(2-aminoethyl)phosphoryl]-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl}-O-acyl-1-phosphatidyl-1D-myo-inositol[er] + dolichyl phosphate[er] YBR004C Glycosylphosphatidylinositol (gpi)-anchor biosynthesis +r_0522 GPI-anchor assembly, step 8 6-O-{alpha-D-mannosyl-(1->6)-2-O-[(2-aminoethyl)phosphoryl]-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl}-O-acyl-1-phosphatidyl-1D-myo-inositol[er] + dolichyl D-mannosyl phosphate[er] <=> 6-O-{alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(1->6)-2-O-[(2-aminoethyl)phosphoryl]-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl}-O-acyl-1-phosphatidyl-1D-myo-inositol[er] YGL142C Glycosylphosphatidylinositol (gpi)-anchor biosynthesis +r_0523 GPI-anchor assembly, step 9 6-O-{alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(1->6)-2-O-[(2-aminoethyl)phosphoryl]-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl}-O-acyl-1-phosphatidyl-1D-myo-inositol[er] + phosphatidylethanolamine backbone[er] <=> 6-[6-(2-aminoethylphosphoryl)-alpha-mannosyl-(1->6)-2-(2-aminoethylphosphoryl)-alpha-mannosyl-(1->6)-alpha-2-(2-aminoethylphosphoryl)mannosyl-(1->4)-alpha-glucosaminyl]-O-acyl-1-phosphatidyl-1D-myo-inositol[er] + diglyceride backbone[er] YDR302W or YLL031C Glycosylphosphatidylinositol (gpi)-anchor biosynthesis +r_0524 GTP cyclohydrolase I GTP[c] + H2O[c] => 7,8-dihydroneopterin 3'-triphosphate[c] + formate[c] + H+[c] YGR267C Folate biosynthesis +r_0525 GTP cyclohydrolase II GTP[c] + 3 H2O[c] => 2,5-diamino-4-hydroxy-6-(5-phosphoribosylamino)pyrimidine[c] + diphosphate[c] + formate[c] + 2 H+[c] YBL033C Riboflavin metabolism +r_0526 guanine deaminase guanine[c] + H+[c] + H2O[c] => 9H-xanthine[c] + ammonium[c] YDL238C Purine metabolism +r_0527 guanine phosphoribosyltransferase guanine[c] + PRPP[c] => diphosphate[c] + GMP[c] YDR399W Purine metabolism +r_0528 guanylate kinase ATP[c] + GMP[c] => ADP[c] + GDP[c] YDR454C Purine metabolism +r_0529 guanylate kinase (GMP:dATP) dATP[c] + GMP[c] <=> dADP[c] + GDP[c] YDR454C Purine metabolism +r_0530 heme O monooxygenase heme o[m] + NADH[m] + oxygen[m] => H2O[m] + heme a[m] + NAD[m] YER141W or (YDR376W and YPL252C) Porphyrin and chlorophyll metabolism +r_0531 Heme O synthase farnesyl diphosphate[m] + ferroheme b[m] + H2O[m] => diphosphate[m] + heme o[m] YPL172C Porphyrin and chlorophyll metabolism +r_0532 hexaprenyldihydroxybenzoate methyltransferase 2-hexaprenyl-5-hydroxy-6-methoxy-3-methyl-1,4-benzoquinone[m] + H+[m] + S-adenosyl-L-methionine[m] => S-adenosyl-L-homocysteine[m] + ubiquinol-6[m] YDR204W and YGL119W and YGR255C and YLR201C and YML110C and YOL096C and YOR125C Ubiquinone and other terpenoid-quinone biosynthesis +r_0533 hexokinase (D-fructose:ATP) ATP[c] + D-fructose[c] => ADP[c] + D-fructose 6-phosphate[c] + H+[c] YLR446W or YFR053C or YGL253W Glycolysis / gluconeogenesis +r_0534 hexokinase (D-glucose:ATP) ATP[c] + D-glucose[c] => ADP[c] + D-glucose 6-phosphate[c] + H+[c] YLR446W or YCL040W or YFR053C or YGL253W or YDR516C Glycolysis / gluconeogenesis +r_0535 hexokinase (D-mannose:ATP) ATP[c] + D-mannose[c] => ADP[c] + D-mannose 6-phosphate[c] + H+[c] YLR446W or YFR053C or YGL253W Glycolysis / gluconeogenesis +r_0536 histidinol dehydrogenase H2O[c] + L-histidinol[c] + 2 NAD[c] => 3 H+[c] + L-histidine[c] + 2 NADH[c] YCL030C Histidine metabolism +r_0537 histidinol-phosphatase H2O[c] + L-histidinol phosphate[c] => L-histidinol[c] + phosphate[c] YFR025C Histidine metabolism +r_0538 histidinol-phosphate transaminase 3-(imidazol-4-yl)-2-oxopropyl dihydrogen phosphate[c] + L-glutamate[c] => 2-oxoglutarate[c] + L-histidinol phosphate[c] YIL116W Histidine metabolism +r_0539 histidyl-tRNA synthetase ATP[c] + L-histidine[c] + tRNA(His)[c] => AMP[c] + diphosphate[c] + His-tRNA(His)[c] YPR033C tRNA metabolism https://www.yeastgenome.org/go/GO:0006399 +r_0540 histidyl-tRNA synthetase ATP[m] + L-histidine[m] + tRNA(His)[m] => AMP[m] + diphosphate[m] + His-tRNA(His)[m] YPR033C tRNA metabolism https://www.yeastgenome.org/go/GO:0006399 +r_0541 hnRNP arginine N-methyltransferase L-histidine[c] + S-adenosyl-L-methionine[c] => H+[c] + N(pros)-methyl-L-histidine[c] + S-adenosyl-L-homocysteine[c] YBR034C Histidine metabolism +r_0542 homoacontinate hydratase but-1-ene-1,2,4-tricarboxylic acid[m] + H2O[m] <=> homoisocitrate[m] YJL200C or YDR234W Lysine metabolism +r_0543 homocitrate synthase 2-oxoglutarate[n] + acetyl-CoA[n] + H2O[n] => coenzyme A[n] + H+[n] + homocitrate[n] YDL131W or YDL182W Pyruvate metabolism +r_0544 homocysteine S-methyltransferase L-homocysteine[c] + S-adenosyl-L-methionine[c] => H+[c] + L-methionine[c] + S-adenosyl-L-homocysteine[c] YLL062C or YPL273W Cysteine and methionine metabolism +r_0545 homoisocitrate dehydrogenase homoisocitrate[m] + NAD[m] => 2-oxoadipic acid[m] + carbon dioxide[m] + NADH[m] YIL094C Lysine metabolism +r_0546 homoserine dehydrogenase (NADH) H+[c] + L-aspartate 4-semialdehyde[c] + NADH[c] => L-homoserine[c] + NAD[c] YJR139C Glycine, serine and threonine metabolism +r_0547 homoserine dehydrogenase (NADP) H+[c] + L-aspartate 4-semialdehyde[c] + NADPH[c] => L-homoserine[c] + NADP(+)[c] YJR139C Glycine, serine and threonine metabolism +r_0548 homoserine kinase ATP[c] + L-homoserine[c] => ADP[c] + H+[c] + O-phospho-L-homoserine[c] YHR025W Glycine, serine and threonine metabolism +r_0549 homoserine O-trans-acetylase acetyl-CoA[c] + L-homoserine[c] => coenzyme A[c] + O-acetyl-L-homoserine[c] YNL277W Cysteine and methionine metabolism +r_0550 hydrogen peroxide reductase (thioredoxin) H+[c] + hydrogen peroxide[c] + TRX1[c] => 2 H2O[c] + TRX1 disulphide[c] (YDR453C and YGR209C) or (YDR453C and YLR043C) Glutathione metabolism https://www.yeastgenome.org/go/GO:0006749 +r_0551 hydrogen peroxide reductase (thioredoxin) H+[m] + hydrogen peroxide[m] + TRX1[m] => 2 H2O[m] + TRX1 disulphide[m] YBL064C and YCR083W Glutathione metabolism https://www.yeastgenome.org/go/GO:0006749 +r_0552 hydrogen peroxide reductase (thioredoxin) H+[p] + hydrogen peroxide[p] + TRX1[p] => 2 H2O[p] + TRX1 disulphide[p] (YGR209C and YLR109W) or (YLR043C and YLR109W) Glutathione metabolism https://www.yeastgenome.org/go/GO:0006749 +r_0553 hydroxyacylglutathione hydrolase (R)-S-lactoylglutathione[c] + H2O[c] => (R)-lactate[c] + glutathione[c] + H+[c] YDR272W Pyruvate metabolism +r_0554 hydroxyacylglutathione hydrolase (R)-S-lactoylglutathione[m] + H2O[m] => (R)-lactate[m] + glutathione[m] + H+[m] YOR040W Pyruvate metabolism +r_0555 hydroxybenzoate octaprenyltransferase 4-hydroxybenzoate[m] + hexaprenyl diphosphate[m] => 3-hexaprenyl-4-hydroxybenzoic acid[m] + diphosphate[m] YNR041C Ubiquinone and other terpenoid-quinone biosynthesis +r_0556 hydroxyethylthiazole kinase 5-(2-hydroxyethyl)-4-methylthiazole[c] + ATP[c] => 4-methyl-5-(2-phosphonooxyethyl)thiazole[c] + ADP[c] + H+[c] YPL214C Thiamine metabolism +r_0557 hydroxymethylbilane synthase H2O[c] + 4 porphobilinogen[c] => 4 ammonium[c] + preuroporphyrinogen[c] YDL205C Porphyrin and chlorophyll metabolism +r_0558 hydroxymethylglutaryl CoA reductase 3-hydroxy-3-methylglutaryl-CoA[c] + 2 H+[c] + 2 NADPH[c] => (R)-mevalonate[c] + coenzyme A[c] + 2 NADP(+)[c] YLR450W or YML075C Terpenoid backbone biosynthesis +r_0559 hydroxymethylglutaryl CoA synthase acetoacetyl-CoA[c] + acetyl-CoA[c] + H2O[c] => 3-hydroxy-3-methylglutaryl-CoA[c] + coenzyme A[c] + H+[c] YML126C Terpenoid backbone biosynthesis +r_0560 hydroxymethylglutaryl CoA synthase acetoacetyl-CoA[m] + acetyl-CoA[m] + H2O[m] => 3-hydroxy-3-methylglutaryl-CoA[m] + coenzyme A[m] + H+[m] YML126C Terpenoid backbone biosynthesis +r_0561 hydroxymethylpyrimidine kinase (ATP) 4-amino-5-hydroxymethyl-2-methylpyrimidine[c] + ATP[c] => 4-amino-2-methyl-5-phosphomethylpyrimidine[c] + ADP[c] + H+[c] YOL055C or YPL258C or YPR121W Thiamine metabolism +r_0562 hypoxanthine phosphoribosyltransferase (Hypoxanthine) hypoxanthine[c] + PRPP[c] => diphosphate[c] + IMP[c] YDR399W Purine metabolism +r_0563 Imidazole-glycerol-3-phosphate synthase 5-[(5-phospho-1-deoxy-D-ribulos-1-ylamino)methylideneamino]-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide[c] + L-glutamine[c] => AICAR[c] + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate[c] + H+[c] + L-glutamate[c] YBR248C Histidine metabolism +r_0564 imidazoleglycerol-phosphate dehydratase D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate[c] => 3-(imidazol-4-yl)-2-oxopropyl dihydrogen phosphate[c] + H2O[c] YOR202W Histidine metabolism +r_0565 IMP dehydrogenase H2O[c] + IMP[c] + NAD[c] => H+[c] + NADH[c] + xanthosine-5-phosphate[c] YHR216W or YLR432W or YML056C Purine metabolism +r_0566 indole-3-glycerol-phosphate synthase 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate[c] + H+[c] => 1-C-(indol-3-yl)glycerol 3-phosphate[c] + carbon dioxide[c] + H2O[c] YKL211C Phenylalanine, tyrosine and tryptophan biosynthesis +r_0567 indole-3-pyruvate decarboxylase H+[c] + indole-3-pyruvate[c] => carbon dioxide[c] + indol-3-ylacetaldehyde[c] YGR087C or YLR044C or YLR134W Tryptophan metabolism +r_0568 inorganic diphosphatase diphosphate[c] + H2O[c] => H+[c] + 2 phosphate[c] YBR011C Oxidative phosphorylation +r_0569 inorganic diphosphatase diphosphate[m] + H2O[m] => H+[m] + 2 phosphate[m] YMR267W Oxidative phosphorylation +r_0570 inosine monophosphate cyclohydrolase phosphoribosyl-formamido-carboxamide[c] <=> H2O[c] + IMP[c] YLR028C or YMR120C Purine metabolism +r_0571 inositol-1,3,4,5,6-pentakisphosphate 2-kinase ATP[n] + myo-inositol 1,3,4,5,6-pentakisphosphate[n] => ADP[n] + H+[n] + myo-inositol hexakisphosphate[n] YDR315C Inositol phosphate metabolism +r_0572 inositol-1,3,4,5-triphosphate 6-kinase, nucleus 1D-myo-inositol 1,3,4,5-tetrakisphosphate[n] + ATP[n] => ADP[n] + H+[n] + myo-inositol 1,3,4,5,6-pentakisphosphate[n] YDR173C Inositol phosphate metabolism +r_0573 inositol-1,4,5,6- tetrakisphosphate 3-kinase, nucleus 1D-myo-inositol 1,4,5,6-tetrakisphosphate[n] + ATP[n] => ADP[n] + H+[n] + myo-inositol 1,3,4,5,6-pentakisphosphate[n] YDR173C Inositol phosphate metabolism +r_0574 inositol-1,4,5-triphosphate 6-kinase, nucleus 1D-myo-inositol 1,4,5-trisphosphate[n] + ATP[n] => 1D-myo-inositol 1,4,5,6-tetrakisphosphate[n] + ADP[n] + H+[n] YDR173C Inositol phosphate metabolism +r_0575 inositol-1,4,5-trisphosphate 3-kinase, nucleus 1D-myo-inositol 1,4,5-trisphosphate[n] + ATP[n] => 1D-myo-inositol 1,3,4,5-tetrakisphosphate[n] + ADP[n] + H+[n] YDR173C Inositol phosphate metabolism +r_0596 IPS phospholipase C H2O[er] + mannosylinositol phosphorylceramide A (C24)[er] => ceramide-1 (C24)[er] + mannose-1D-myo-inositol 1-phosphate[er] YER019W Sphingolipid metabolism +r_0597 IPS phospholipase C H2O[er] + mannosylinositol phosphorylceramide A (C26)[er] => ceramide-1 (C26)[er] + mannose-1D-myo-inositol 1-phosphate[er] YER019W Sphingolipid metabolism +r_0598 IPS phospholipase C H2O[er] + mannosylinositol phosphorylceramide B' (C24)[er] => ceramide-2' (C24)[er] + mannose-1D-myo-inositol 1-phosphate[er] YER019W Sphingolipid metabolism +r_0599 IPS phospholipase C H2O[er] + mannosylinositol phosphorylceramide B' (C26)[er] => ceramide-2' (C26)[er] + mannose-1D-myo-inositol 1-phosphate[er] YER019W Sphingolipid metabolism +r_0600 IPS phospholipase C H2O[er] + mannosylinositol phosphorylceramide B (C24)[er] => ceramide-2 (C24)[er] + mannose-1D-myo-inositol 1-phosphate[er] YER019W Sphingolipid metabolism +r_0601 IPS phospholipase C H2O[er] + mannosylinositol phosphorylceramide B (C26)[er] => ceramide-2 (C26)[er] + mannose-1D-myo-inositol 1-phosphate[er] YER019W Sphingolipid metabolism +r_0602 IPS phospholipase C H2O[er] + mannosylinositol phosphorylceramide C (C24)[er] => ceramide-3 (C24)[er] + mannose-1D-myo-inositol 1-phosphate[er] YER019W Sphingolipid metabolism +r_0603 IPS phospholipase C H2O[er] + mannosylinositol phosphorylceramide C (C26)[er] => ceramide-3 (C26)[er] + mannose-1D-myo-inositol 1-phosphate[er] YER019W Sphingolipid metabolism +r_0604 IPS phospholipase C H2O[er] + mannosylinositol phosphorylceramide D (C24)[er] => ceramide-4 (C24)[er] + mannose-1D-myo-inositol 1-phosphate[er] YER019W Sphingolipid metabolism +r_0605 IPS phospholipase C H2O[er] + mannosylinositol phosphorylceramide D (C26)[er] => ceramide-4 (C26)[er] + mannose-1D-myo-inositol 1-phosphate[er] YER019W Sphingolipid metabolism +r_0606 IPS phospholipase C H2O[er] + inositol phosphomannosylinositol phosphoceramide A (C24)[er] => ceramide-1 (C24)[er] + mannose-(1D-myo-inositol 1-phosphate)2[er] YER019W Sphingolipid metabolism +r_0607 IPS phospholipase C H2O[er] + inositol phosphomannosylinositol phosphoceramide A (C26)[er] => ceramide-1 (C26)[er] + mannose-(1D-myo-inositol 1-phosphate)2[er] YER019W Sphingolipid metabolism +r_0608 IPS phospholipase C H2O[er] + inositol phosphomannosylinositol phosphoceramide B' (C24)[er] => ceramide-2' (C24)[er] + mannose-(1D-myo-inositol 1-phosphate)2[er] YER019W Sphingolipid metabolism +r_0609 IPS phospholipase C H2O[er] + inositol phosphomannosylinositol phosphoceramide B' (C26)[er] => ceramide-2' (C26)[er] + mannose-(1D-myo-inositol 1-phosphate)2[er] YER019W Sphingolipid metabolism +r_0610 IPS phospholipase C H2O[er] + inositol phosphomannosylinositol phosphoceramide B (C24)[er] => ceramide-2 (C24)[er] + mannose-(1D-myo-inositol 1-phosphate)2[er] YER019W Sphingolipid metabolism +r_0611 IPS phospholipase C H2O[er] + inositol phosphomannosylinositol phosphoceramide B (C26)[er] => ceramide-2 (C26)[er] + mannose-(1D-myo-inositol 1-phosphate)2[er] YER019W Sphingolipid metabolism +r_0612 IPS phospholipase C H2O[er] + inositol phosphomannosylinositol phosphoceramide C (C24)[er] => ceramide-3 (C24)[er] + mannose-(1D-myo-inositol 1-phosphate)2[er] YER019W Sphingolipid metabolism +r_0613 IPS phospholipase C H2O[er] + inositol phosphomannosylinositol phosphoceramide C (C26)[er] => ceramide-3 (C26)[er] + mannose-(1D-myo-inositol 1-phosphate)2[er] YER019W Sphingolipid metabolism +r_0614 IPS phospholipase C H2O[er] + inositol phosphomannosylinositol phosphoceramide D (C24)[er] => ceramide-4 (C24)[er] + mannose-(1D-myo-inositol 1-phosphate)2[er] YER019W Sphingolipid metabolism +r_0615 IPS phospholipase C H2O[er] + inositol phosphomannosylinositol phosphoceramide D (C26)[er] => ceramide-4 (C26)[er] + mannose-(1D-myo-inositol 1-phosphate)2[er] YER019W Sphingolipid metabolism +r_0616 IPS phospholipase C H2O[m] + inositol-P-ceramide A (C24)[m] => 1D-myo-inositol 3-phosphate[m] + ceramide-1 (C24)[m] + 2 H+[m] YER019W Sphingolipid metabolism +r_0617 IPS phospholipase C H2O[m] + inositol-P-ceramide A (C26)[m] => 1D-myo-inositol 3-phosphate[m] + ceramide-1 (C26)[m] + 2 H+[m] YER019W Sphingolipid metabolism +r_0618 IPS phospholipase C H2O[m] + inositol-P-ceramide B' (C24)[m] => 1D-myo-inositol 3-phosphate[m] + ceramide-2' (C24)[m] + 2 H+[m] YER019W Sphingolipid metabolism +r_0619 IPS phospholipase C H2O[m] + inositol-P-ceramide B' (C26)[m] => 1D-myo-inositol 3-phosphate[m] + ceramide-2' (C26)[m] + 2 H+[m] YER019W Sphingolipid metabolism +r_0620 IPS phospholipase C H2O[m] + inositol-P-ceramide B (C24)[m] => 1D-myo-inositol 3-phosphate[m] + ceramide-2 (C24)[m] + 2 H+[m] YER019W Sphingolipid metabolism +r_0621 IPS phospholipase C H2O[m] + inositol-P-ceramide B (C26)[m] => 1D-myo-inositol 3-phosphate[m] + ceramide-2 (C26)[m] + 2 H+[m] YER019W Sphingolipid metabolism +r_0622 IPS phospholipase C H2O[m] + inositol-P-ceramide C (C24)[m] => 1D-myo-inositol 3-phosphate[m] + ceramide-3 (C24)[m] + 2 H+[m] YER019W Sphingolipid metabolism +r_0623 IPS phospholipase C H2O[m] + inositol-P-ceramide C (C26)[m] => 1D-myo-inositol 3-phosphate[m] + ceramide-3 (C26)[m] + 2 H+[m] YER019W Sphingolipid metabolism +r_0624 IPS phospholipase C H2O[m] + inositol-P-ceramide D (C24)[m] => 1D-myo-inositol 3-phosphate[m] + ceramide-4 (C24)[m] + 2 H+[m] YER019W Sphingolipid metabolism +r_0625 IPS phospholipase C H2O[m] + inositol-P-ceramide D (C26)[m] => 1D-myo-inositol 3-phosphate[m] + ceramide-4 (C26)[m] + 2 H+[m] YER019W Sphingolipid metabolism +r_0626 IPS phospholipase C H2O[m] + mannosylinositol phosphorylceramide A (C24)[m] => ceramide-1 (C24)[m] + mannose-1D-myo-inositol 1-phosphate[m] YER019W Sphingolipid metabolism +r_0627 IPS phospholipase C H2O[m] + mannosylinositol phosphorylceramide A (C26)[m] => ceramide-1 (C26)[m] + mannose-1D-myo-inositol 1-phosphate[m] YER019W Sphingolipid metabolism +r_0628 IPS phospholipase C H2O[m] + mannosylinositol phosphorylceramide B' (C24)[m] => ceramide-2' (C24)[m] + mannose-1D-myo-inositol 1-phosphate[m] YER019W Sphingolipid metabolism +r_0629 IPS phospholipase C H2O[m] + mannosylinositol phosphorylceramide B' (C26)[m] => ceramide-2' (C26)[m] + mannose-1D-myo-inositol 1-phosphate[m] YER019W Sphingolipid metabolism +r_0630 IPS phospholipase C H2O[m] + mannosylinositol phosphorylceramide B (C24)[m] => ceramide-2 (C24)[m] + mannose-1D-myo-inositol 1-phosphate[m] YER019W Sphingolipid metabolism +r_0631 IPS phospholipase C H2O[m] + mannosylinositol phosphorylceramide B (C26)[m] => ceramide-2 (C26)[m] + mannose-1D-myo-inositol 1-phosphate[m] YER019W Sphingolipid metabolism +r_0632 IPS phospholipase C H2O[m] + mannosylinositol phosphorylceramide C (C24)[m] => ceramide-3 (C24)[m] + mannose-1D-myo-inositol 1-phosphate[m] YER019W Sphingolipid metabolism +r_0633 IPS phospholipase C H2O[m] + mannosylinositol phosphorylceramide C (C26)[m] => ceramide-3 (C26)[m] + mannose-1D-myo-inositol 1-phosphate[m] YER019W Sphingolipid metabolism +r_0634 IPS phospholipase C H2O[m] + mannosylinositol phosphorylceramide D (C24)[m] => ceramide-4 (C24)[m] + mannose-1D-myo-inositol 1-phosphate[m] YER019W Sphingolipid metabolism +r_0635 IPS phospholipase C H2O[m] + mannosylinositol phosphorylceramide D (C26)[m] => ceramide-4 (C26)[m] + mannose-1D-myo-inositol 1-phosphate[m] YER019W Sphingolipid metabolism +r_0636 IPS phospholipase C H2O[m] + inositol phosphomannosylinositol phosphoceramide A (C24)[m] => ceramide-1 (C24)[m] + mannose-(1D-myo-inositol 1-phosphate)2[m] YER019W Sphingolipid metabolism +r_0637 IPS phospholipase C H2O[m] + inositol phosphomannosylinositol phosphoceramide A (C26)[m] => ceramide-1 (C26)[m] + mannose-(1D-myo-inositol 1-phosphate)2[m] YER019W Sphingolipid metabolism +r_0638 IPS phospholipase C H2O[m] + inositol phosphomannosylinositol phosphoceramide B' (C24)[m] => ceramide-2' (C24)[m] + mannose-(1D-myo-inositol 1-phosphate)2[m] YER019W Sphingolipid metabolism +r_0639 IPS phospholipase C H2O[m] + inositol phosphomannosylinositol phosphoceramide B' (C26)[m] => ceramide-2' (C26)[m] + mannose-(1D-myo-inositol 1-phosphate)2[m] YER019W Sphingolipid metabolism +r_0640 IPS phospholipase C H2O[m] + inositol phosphomannosylinositol phosphoceramide B (C24)[m] => ceramide-2 (C24)[m] + mannose-(1D-myo-inositol 1-phosphate)2[m] YER019W Sphingolipid metabolism +r_0641 IPS phospholipase C H2O[m] + inositol phosphomannosylinositol phosphoceramide B (C26)[m] => ceramide-2 (C26)[m] + mannose-(1D-myo-inositol 1-phosphate)2[m] YER019W Sphingolipid metabolism +r_0642 IPS phospholipase C H2O[m] + inositol phosphomannosylinositol phosphoceramide C (C24)[m] => ceramide-3 (C24)[m] + mannose-(1D-myo-inositol 1-phosphate)2[m] YER019W Sphingolipid metabolism +r_0643 IPS phospholipase C H2O[m] + inositol phosphomannosylinositol phosphoceramide C (C26)[m] => ceramide-3 (C26)[m] + mannose-(1D-myo-inositol 1-phosphate)2[m] YER019W Sphingolipid metabolism +r_0644 IPS phospholipase C H2O[m] + inositol phosphomannosylinositol phosphoceramide D (C24)[m] => ceramide-4 (C24)[m] + mannose-(1D-myo-inositol 1-phosphate)2[m] YER019W Sphingolipid metabolism +r_0645 IPS phospholipase C H2O[m] + inositol phosphomannosylinositol phosphoceramide D (C26)[m] => ceramide-4 (C26)[m] + mannose-(1D-myo-inositol 1-phosphate)2[m] YER019W Sphingolipid metabolism +r_0646 IPS phospholipase C H2O[er] + inositol-P-ceramide A (C24)[er] => 1D-myo-inositol 1-phosphate[er] + ceramide-1 (C24)[er] + 2 H+[er] YER019W Sphingolipid metabolism +r_0647 IPS phospholipase C H2O[er] + inositol-P-ceramide A (C26)[er] => 1D-myo-inositol 1-phosphate[er] + ceramide-1 (C26)[er] + 2 H+[er] YER019W Sphingolipid metabolism +r_0648 IPS phospholipase C H2O[er] + inositol-P-ceramide B' (C24)[er] => 1D-myo-inositol 1-phosphate[er] + ceramide-2' (C24)[er] + 2 H+[er] YER019W Sphingolipid metabolism +r_0649 IPS phospholipase C H2O[er] + inositol-P-ceramide B' (C26)[er] => 1D-myo-inositol 1-phosphate[er] + ceramide-2' (C26)[er] + 2 H+[er] YER019W Sphingolipid metabolism +r_0650 IPS phospholipase C H2O[er] + inositol-P-ceramide B (C24)[er] => 1D-myo-inositol 1-phosphate[er] + ceramide-2 (C24)[er] + 2 H+[er] YER019W Sphingolipid metabolism +r_0651 IPS phospholipase C H2O[er] + inositol-P-ceramide B (C26)[er] => 1D-myo-inositol 1-phosphate[er] + ceramide-2 (C26)[er] + 2 H+[er] YER019W Sphingolipid metabolism +r_0652 IPS phospholipase C H2O[er] + inositol-P-ceramide C (C24)[er] => 1D-myo-inositol 1-phosphate[er] + ceramide-3 (C24)[er] + 2 H+[er] YER019W Sphingolipid metabolism +r_0653 IPS phospholipase C H2O[er] + inositol-P-ceramide C (C26)[er] => 1D-myo-inositol 1-phosphate[er] + ceramide-3 (C26)[er] + 2 H+[er] YER019W Sphingolipid metabolism +r_0654 IPS phospholipase C H2O[er] + inositol-P-ceramide D (C24)[er] => 1D-myo-inositol 1-phosphate[er] + ceramide-4 (C24)[er] + 2 H+[er] YER019W Sphingolipid metabolism +r_0655 IPS phospholipase C H2O[er] + inositol-P-ceramide D (C26)[er] => 1D-myo-inositol 1-phosphate[er] + ceramide-4 (C26)[er] + 2 H+[er] YER019W Sphingolipid metabolism +r_0656 isoamyl acetate-hydrolyzing esterase H2O[c] + isoamyl acetate[c] => acetate[c] + H+[c] + isoamylol[c] YOR126C Complex alcohol metabolism +r_0657 isobutyl acetate-hydrolyzing esterase H2O[c] + isobutyl acetate[c] => acetate[c] + H+[c] + isobutanol[c] YOR126C Complex alcohol metabolism +r_0658 isocitrate dehydrogenase (NAD+) isocitrate[m] + NAD[m] => 2-oxoglutarate[m] + carbon dioxide[m] + NADH[m] YNL037C and YOR136W Citrate cycle (TCA cycle) +r_0659 isocitrate dehydrogenase (NADP) isocitrate[c] + NADP(+)[c] <=> 2-oxoglutarate[c] + carbon dioxide[c] + NADPH[c] YLR174W Citrate cycle (TCA cycle) +r_0661 isocitrate dehydrogenase (NADP+), peroxisomal isocitrate[p] + NADP(+)[p] => 2-oxoglutarate[p] + carbon dioxide[p] + NADPH[p] YNL009W Citrate cycle (TCA cycle) +r_0662 isocitrate lyase isocitrate[c] => glyoxylate[c] + succinate[c] YER065C Glyoxylate and dicarboxylate metabolism +r_0663 isoleucine transaminase 2-oxoglutarate[c] + L-isoleucine[c] <=> (S)-3-methyl-2-oxopentanoate[c] + L-glutamate[c] YJR148W Valine, leucine and isoleucine metabolism +r_0664 isoleucine transaminase 2-oxoglutarate[m] + L-isoleucine[m] <=> (S)-3-methyl-2-oxopentanoate[m] + L-glutamate[m] YHR208W Valine, leucine and isoleucine metabolism +r_0665 isoleucyl-tRNA synthetase ATP[c] + L-isoleucine[c] + tRNA(Ile)[c] => AMP[c] + diphosphate[c] + Ile-tRNA(Ile)[c] YBL076C tRNA metabolism https://www.yeastgenome.org/go/GO:0006399 +r_0666 isoleucyl-tRNA synthetase ATP[m] + L-isoleucine[m] + tRNA(Ile)[m] => AMP[m] + diphosphate[m] + Ile-tRNA(Ile)[m] YPL040C tRNA metabolism https://www.yeastgenome.org/go/GO:0006399 +r_0667 isopentenyl-diphosphate D-isomerase isopentenyl diphosphate[c] <=> prenyl diphosphate(3-)[c] YPL117C Terpenoid backbone biosynthesis +r_0668 itaconate-CoA ligase (ADP-forming) ATP[m] + coenzyme A[m] + itaconate[m] <=> ADP[m] + itaconyl-CoA[m] + phosphate[m] YGR244C and YOR142W C5-branched dibasic acid metabolism +r_0669 ketol-acid reductoisomerase (2-aceto-2-hydroxybutanoate) (S)-2-acetyl-2-hydroxybutanoate[m] + H+[m] + NADPH[m] => (2R,3R)-2,3-dihydroxy-3-methylpentanoate[m] + NADP(+)[m] YLR355C Valine, leucine and isoleucine metabolism +r_0670 kynureninase H2O[c] + L-kynurenine[c] => anthranilate[c] + H+[c] + L-alanine[c] YLR231C Tryptophan metabolism +r_0671 kynurenine 3-monooxygenase H+[c] + L-kynurenine[c] + NADPH[c] + oxygen[c] => 3-hydroxy-L-kynurenine[c] + H2O[c] + NADP(+)[c] YBL098W Tryptophan metabolism +r_0672 L-1-pyrroline-3-hydroxy-5-carboxylate dehydrogenase 1-pyrroline-3-hydroxy-5-carboxylic acid[m] + 2 H2O[m] + NAD[m] <=> erythro-4-hydroxy-L-glutamic acid[m] + H+[m] + NADH[m] YHR037W Arginine and proline metabolism +r_0673 L-4-hydroxyglutamate semialdehyde dehydrogenase H2O[m] + L-4-hydroxyglutamic semialdehyde[m] + NAD[m] <=> erythro-4-hydroxy-L-glutamic acid[m] + 2 H+[m] + NADH[m] YHR037W Arginine and proline metabolism +r_0674 L-alanine transaminase 2-oxoglutarate[m] + L-alanine[m] <=> L-glutamate[m] + pyruvate[m] YLR089C Alanine, aspartate and glutamate metabolism +r_0675 L-allo-threonine aldolase L-allothreonine[c] => acetaldehyde[c] + L-glycine[c] YEL046C Glycine, serine and threonine metabolism +r_0676 L-allo-threonine dehydrogenase L-allothreonine[c] + NADP(+)[c] <=> H+[c] + L-2-amino-3-oxobutanoate[c] + NADPH[c] YMR226C Glycine, serine and threonine metabolism +r_0678 L-aminoadipate-semialdehyde dehydrogenase (NADPH) ATP[c] + H+[c] + L-2-aminoadipate[c] + NADPH[c] => AMP[c] + diphosphate[c] + L-allysine[c] + NADP(+)[c] YBR115C and YGL154C Lysine metabolism +r_0679 L-asparaginase H2O[c] + L-asparagine[c] => ammonium[c] + L-aspartate[c] YDR321W Alanine, aspartate and glutamate metabolism +r_0680 L-asparaginase H2O[e] + L-asparagine[e] => ammonium[e] + L-aspartate[e] YLR155C or YLR157C or YLR158C or YLR160C Alanine, aspartate and glutamate metabolism +r_0681 L-erythro-4-hydroxyglutamate:2-oxoglutarate aminotransferase 2-oxoglutarate[c] + erythro-4-hydroxy-L-glutamic acid[c] => 4-hydroxy-2-oxoglutarate[c] + L-glutamate[c] YLR027C Arginine and proline metabolism +r_0682 L-erythro-4-hydroxyglutamate:2-oxoglutarate aminotransferase 2-oxoglutarate[m] + erythro-4-hydroxy-L-glutamic acid[m] => 4-hydroxy-2-oxoglutarate[m] + L-glutamate[m] YKL106W Arginine and proline metabolism +r_0683 L-erythro-4-hydroxyglutamate:2-oxoglutarate aminotransferase 2-oxoglutarate[p] + erythro-4-hydroxy-L-glutamic acid[p] => 4-hydroxy-2-oxoglutarate[p] + L-glutamate[p] YLR027C Arginine and proline metabolism +r_0687 L-hydroxyproline reductase (NADP) 1-pyrroline-3-hydroxy-5-carboxylic acid[c] + 2 H+[c] + NADPH[c] => NADP(+)[c] + trans-4-hydroxy-L-proline[c] YER023W Arginine and proline metabolism +r_0688 L-lactaldehyde:NADP+ 1-oxidoreductase H+[c] + methylglyoxal[c] + NADPH[c] => (S)-lactaldehyde[c] + NADP(+)[c] YHR104W or YOL151W Pyruvate metabolism +r_0689 L-serine deaminase L-serine[c] => ammonium[c] + pyruvate[c] YCL064C Glycine, serine and threonine metabolism +r_0690 L-serine dehydrogenase L-serine[c] + NADP(+)[c] => H+[c] + L-alpha-formylglycine[c] + NADPH[c] YMR226C Glycine, serine and threonine metabolism +r_0691 L-sorbitol dehydrogenase (L-sorbose-producing) L-glucitol[c] + NAD[c] => H+[c] + L-sorbose[c] + NADH[c] YJR159W Fructose and mannose metabolism +r_0692 L-threonine deaminase L-threonine[c] => 2-oxobutanoate[c] + ammonium[c] YCL064C Glycine, serine and threonine metabolism +r_0693 L-threonine deaminase L-threonine[m] => 2-oxobutanoate[m] + ammonium[m] YER086W Glycine, serine and threonine metabolism +r_0694 L-tryptophan:oxygen 2,3-oxidoreductase (decyclizing) L-tryptophan[c] + oxygen[c] => N-formyl-L-kynurenine[c] YJR078W Tryptophan metabolism +r_0695 L-tyrosine N-formyltransferase 10-formyl-THF[c] + L-tyrosine[c] => H+[c] + N-formyl-L-tyrosine[c] + THF[c] YDR403W Tryptophan metabolism r_0763 +r_0696 lactaldehyde dehydrogenase (S)-lactaldehyde[c] + H2O[c] + NAD[c] => (S)-lactate[c] + 2 H+[c] + NADH[c] YOL151W Pyruvate metabolism +r_0697 lactoylglutathione lyase glutathione[c] + methylglyoxal[c] => (R)-S-lactoylglutathione[c] YML004C Pyruvate metabolism +r_0698 lanosterol synthase (S)-2,3-epoxysqualene[c] => lanosterol[c] YHR072W Steroid biosynthesis +r_0699 leucine transaminase 2-oxoglutarate[c] + L-leucine[c] <=> 4-methyl-2-oxopentanoate[c] + L-glutamate[c] YJR148W Valine, leucine and isoleucine metabolism +r_0700 leucine transaminase 2-oxoglutarate[m] + L-leucine[m] <=> 4-methyl-2-oxopentanoate[m] + L-glutamate[m] YHR208W Valine, leucine and isoleucine metabolism +r_0701 leucyl-tRNA synthetase ATP[c] + L-leucine[c] + tRNA(Leu)[c] => AMP[c] + diphosphate[c] + Leu-tRNA(Leu)[c] YPL160W tRNA metabolism https://www.yeastgenome.org/go/GO:0006399 +r_0702 leucyl-tRNA synthetase ATP[m] + L-leucine[m] + tRNA(Leu)[m] => AMP[m] + diphosphate[m] + Leu-tRNA(Leu)[m] YLR382C tRNA metabolism https://www.yeastgenome.org/go/GO:0006399 +r_0703 leukotriene A4 hydrolase H2O[c] + leukotriene A4[c] <=> (5S,6S)-di-HETE[c] YNL045W Arachidonic acid metabolism +r_0704 leukotriene A4 hydrolase H2O[n] + leukotriene A4[n] <=> (5S,6S)-di-HETE[n] YNL045W Arachidonic acid metabolism +r_0705 leukotriene A4 hydrolase H2O[c] + leukotriene A4[c] <=> Delta(6)-trans,Delta(8)-cis-leukotriene B4[c] YNL045W Arachidonic acid metabolism +r_0706 leukotriene A4 hydrolase H2O[n] + leukotriene A4[n] <=> Delta(6)-trans,Delta(8)-cis-leukotriene B4[n] YNL045W Arachidonic acid metabolism +r_0707 leukotriene A4 hydrolase H2O[c] + leukotriene A4[c] <=> leukotriene B4[c] YNL045W Arachidonic acid metabolism +r_0708 leukotriene A4 hydrolase H2O[n] + leukotriene A4[n] <=> leukotriene B4[n] YNL045W Arachidonic acid metabolism +r_0711 lysyl-tRNA synthetase ATP[c] + L-lysine[c] + tRNA(Lys)[c] => AMP[c] + diphosphate[c] + Lys-tRNA(Lys)[c] YDR037W tRNA metabolism https://www.yeastgenome.org/go/GO:0006399 +r_0712 lysyl-tRNA synthetase ATP[m] + L-lysine[m] + tRNA(Lys)[m] => AMP[m] + diphosphate[m] + Lys-tRNA(Lys)[m] YNL073W tRNA metabolism https://www.yeastgenome.org/go/GO:0006399 +r_0713 malate dehydrogenase (S)-malate[m] + NAD[m] <=> H+[m] + NADH[m] + oxaloacetate[m] YKL085W Citrate cycle (TCA cycle) +r_0714 malate dehydrogenase, cytoplasmic (S)-malate[c] + NAD[c] <=> H+[c] + NADH[c] + oxaloacetate[c] YOL126C Citrate cycle (TCA cycle) +r_0715 malate dehydrogenase, peroxisomal (S)-malate[p] + NAD[p] <=> H+[p] + NADH[p] + oxaloacetate[p] YDL078C Citrate cycle (TCA cycle) +r_0716 malate synthase acetyl-CoA[c] + glyoxylate[c] + H2O[c] => (S)-malate[c] + coenzyme A[c] + H+[c] YIR031C or YNL117W Pyruvate metabolism +r_0717 malate synthase acetyl-CoA[p] + glyoxylate[p] + H2O[p] => (S)-malate[p] + coenzyme A[p] + H+[p] YNL117W Pyruvate metabolism +r_0718 malic enzyme (NAD) (S)-malate[m] + NAD[m] => carbon dioxide[m] + NADH[m] + pyruvate[m] YKL029C Pyruvate metabolism +r_0719 malic enzyme (NADP) (S)-malate[m] + NADP(+)[m] => carbon dioxide[m] + NADPH[m] + pyruvate[m] YKL029C Pyruvate metabolism +r_0721 malonyl-CoA-ACP transacylase malonyl-CoA[m] + ACP1[m] <=> carboxyacetyl-ACP[m] + coenzyme A[m] YKL192C and YOR221C Fatty acid biosynthesis +r_0722 mannose-1-phosphate guanylyltransferase D-mannose 1-phosphate[c] + GTP[c] + H+[c] => diphosphate[c] + GDP-alpha-D-mannose[c] YDL055C Fructose and mannose metabolism +r_0723 mannose-6-phosphate isomerase D-mannose 6-phosphate[c] <=> D-fructose 6-phosphate[c] YER003C Fructose and mannose metabolism +r_0724 methenyltetrahydrifikate cyclohydrolase 5,10-methenyl-THF[m] + H2O[m] <=> 10-formyl-THF[m] + H+[m] YBR084W One carbon pool by folate +r_0725 methenyltetrahydrofolate cyclohydrolase 5,10-methenyl-THF[c] + H2O[c] <=> 10-formyl-THF[c] + H+[c] YGR204W One carbon pool by folate +r_0726 methionine adenosyltransferase ATP[c] + H2O[c] + L-methionine[c] => diphosphate[c] + phosphate[c] + S-adenosyl-L-methionine[c] YDR502C or YLR180W Cysteine and methionine metabolism +r_0727 methionine synthase 5-methyltetrahydrofolate[c] + L-homocysteine[c] => L-methionine[c] + THF[c] YER091C Cysteine and methionine metabolism +r_0728 methionyl-tRNA formyltransferase 10-formyl-THF[m] + Met-tRNA(Met)[m] => fMet-tRNA(fMet)[m] + H+[m] + THF[m] YBL013W tRNA metabolism https://www.yeastgenome.org/go/GO:0006399 +r_0729 methionyl-tRNA synthetase ATP[c] + L-methionine[c] + tRNA(Met)[c] => AMP[c] + diphosphate[c] + Met-tRNA(Met)[c] YGR264C tRNA metabolism https://www.yeastgenome.org/go/GO:0006399 +r_0730 methionyl-tRNA synthetase ATP[m] + L-methionine[m] + tRNA(Met)[m] => AMP[m] + diphosphate[m] + Met-tRNA(Met)[m] YGR171C tRNA metabolism https://www.yeastgenome.org/go/GO:0006399 +r_0731 methylenetetrahydrofolate dehydrogenase (NAD) 5,10-methylenetetrahydrofolate[c] + NAD[c] => 5,10-methenyl-THF[c] + NADH[c] YKR080W One carbon pool by folate +r_0732 methylenetetrahydrofolate dehydrogenase (NADP) 5,10-methylenetetrahydrofolate[c] + NADP(+)[c] <=> 5,10-methenyl-THF[c] + NADPH[c] YGR204W One carbon pool by folate +r_0733 methylenetetrahydrofolate dehydrogenase (NADP) 5,10-methylenetetrahydrofolate[m] + NADP(+)[m] <=> 5,10-methenyl-THF[m] + NADPH[m] YBR084W One carbon pool by folate +r_0734 methylisocitrate lyase (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylic acid[m] => pyruvate[m] + succinate[m] YPR006C Propanoate metabolism +r_0735 mevalonate kinase (atp) (R)-mevalonate[c] + ATP[c] => (R)-5-phosphomevalonic acid[c] + ADP[c] + H+[c] YMR208W Terpenoid backbone biosynthesis +r_0736 mevalonate kinase (ctp) (R)-mevalonate[c] + CTP[c] => (R)-5-phosphomevalonic acid[c] + CDP[c] + H+[c] YMR208W Terpenoid backbone biosynthesis +r_0737 mevalonate kinase (gtp) (R)-mevalonate[c] + GTP[c] => (R)-5-phosphomevalonic acid[c] + GDP[c] + H+[c] YMR208W Terpenoid backbone biosynthesis +r_0738 mevalonate kinase (UTP) (R)-mevalonate[c] + UTP[c] => (R)-5-phosphomevalonic acid[c] + H+[c] + UDP[c] YMR208W Terpenoid backbone biosynthesis +r_0739 mevalonate pyrophoshate decarboxylase (R)-5-diphosphomevalonic acid[c] + ATP[c] => ADP[c] + carbon dioxide[c] + isopentenyl diphosphate[c] + phosphate[c] YNR043W Terpenoid backbone biosynthesis +r_0747 MIPC synthase GDP-alpha-D-mannose[g] + inositol-P-ceramide A (C24)[g] => GDP[g] + H+[g] + mannosylinositol phosphorylceramide A (C24)[g] (YBR036C and YBR161W) or (YBR036C and YPL057C) Sphingoglycolipid metabolism +r_0748 MIPC synthase GDP-alpha-D-mannose[g] + inositol-P-ceramide A (C26)[g] => GDP[g] + H+[g] + mannosylinositol phosphorylceramide A (C26)[g] (YBR036C and YBR161W) or (YBR036C and YPL057C) Sphingoglycolipid metabolism +r_0749 MIPC synthase GDP-alpha-D-mannose[g] + inositol-P-ceramide B' (C24)[g] => GDP[g] + H+[g] + mannosylinositol phosphorylceramide B' (C24)[g] (YBR036C and YBR161W) or (YBR036C and YPL057C) Sphingoglycolipid metabolism +r_0750 MIPC synthase GDP-alpha-D-mannose[g] + inositol-P-ceramide B' (C26)[g] => GDP[g] + H+[g] + mannosylinositol phosphorylceramide B' (C26)[g] (YBR036C and YBR161W) or (YBR036C and YPL057C) Sphingoglycolipid metabolism +r_0751 MIPC synthase GDP-alpha-D-mannose[g] + inositol-P-ceramide B (C24)[g] => GDP[g] + H+[g] + mannosylinositol phosphorylceramide B (C24)[g] (YBR036C and YBR161W) or (YBR036C and YPL057C) Sphingoglycolipid metabolism +r_0752 MIPC synthase GDP-alpha-D-mannose[g] + inositol-P-ceramide B (C26)[g] => GDP[g] + H+[g] + mannosylinositol phosphorylceramide B (C26)[g] (YBR036C and YBR161W) or (YBR036C and YPL057C) Sphingoglycolipid metabolism +r_0753 MIPC synthase GDP-alpha-D-mannose[g] + inositol-P-ceramide C (C24)[g] => GDP[g] + H+[g] + mannosylinositol phosphorylceramide C (C24)[g] (YBR036C and YBR161W) or (YBR036C and YPL057C) Sphingoglycolipid metabolism +r_0754 MIPC synthase GDP-alpha-D-mannose[g] + inositol-P-ceramide C (C26)[g] => GDP[g] + H+[g] + mannosylinositol phosphorylceramide C (C26)[g] (YBR036C and YBR161W) or (YBR036C and YPL057C) Sphingoglycolipid metabolism +r_0755 MIPC synthase GDP-alpha-D-mannose[g] + inositol-P-ceramide D (C24)[g] => GDP[g] + H+[g] + mannosylinositol phosphorylceramide D (C24)[g] (YBR036C and YBR161W) or (YBR036C and YPL057C) Sphingoglycolipid metabolism +r_0756 MIPC synthase GDP-alpha-D-mannose[g] + inositol-P-ceramide D (C26)[g] => GDP[g] + H+[g] + mannosylinositol phosphorylceramide D (C26)[g] (YBR036C and YBR161W) or (YBR036C and YPL057C) Sphingoglycolipid metabolism +r_0757 myo-inositol 1-phosphatase 1D-myo-inositol 1-phosphate[c] + H2O[c] => myo-inositol[c] + phosphate[c] YDR287W or YHR046C Inositol phosphate metabolism +r_0758 myo-inositol-1-phosphate synthase D-glucose 6-phosphate[c] => 1D-myo-inositol 1-phosphate[c] YJL153C Inositol phosphate metabolism +r_0759 N-acetyl-g-glutamyl-phosphate reductase H+[m] + N-acetyl-L-gamma-glutamyl phosphate[m] + NADPH[m] => 2-acetamido-5-oxopentanoate[m] + NADP(+)[m] + phosphate[m] YER069W Arginine biosynthesis +r_0760 N-acetylglucosamine-6-phosphate synthase acetyl-CoA[c] + alpha-D-glucosamine 6-phosphate[c] => coenzyme A[c] + H+[c] + N-acetyl-D-glucosamine 6-phosphate[c] YFL017C Amino sugar and nucleotide sugar metabolism +r_0761 N-acteylglutamate synthase acetyl-CoA[m] + L-glutamate[m] <=> coenzyme A[m] + H+[m] + N-acetyl-L-glutamate[m] YJL071W or YMR062C Arginine biosynthesis +r_0762 N-formyl-L-kynurenine amidohydrolase H2O[c] + N-formyl-L-kynurenine[c] => formate[c] + H+[c] + L-kynurenine[c] YDR428C Tryptophan metabolism +r_0763 N-formyltyrosine oxidase H+[c] + 2 N-formyl-L-tyrosine[c] + NADPH[c] => N,N'-diformyldityrosine[c] + NADP(+)[c] YDR402C and YDR403W Tryptophan metabolism +r_0764 NAD diphosphatase H2O[p] + NAD[p] => AMP[p] + 2 H+[p] + NMN[p] YGL067W Nicotinate and nicotinamide metabolism +r_0765 NAD kinase ATP[c] + NAD[c] => ADP[c] + H+[c] + NADP(+)[c] YEL041W or YJR049C Nicotinate and nicotinamide metabolism +r_0766 NAD kinase ATP[m] + NAD[m] => ADP[m] + H+[m] + NADP(+)[m] YEL041W or YJR049C or YPL188W Nicotinate and nicotinamide metabolism +r_0767 NAD nucleosidase nuclear H2O[n] + NAD[n] => ADP-ribose[n] + H+[n] + nicotinamide[n] YDL042C or YDR191W or YOL068C or YOR025W or YPL015C Nicotinate and nicotinamide metabolism +r_0768 NAD synthase ATP[c] + deamido-NAD(+)[c] + H2O[c] + L-glutamine[c] => AMP[c] + diphosphate[c] + H+[c] + L-glutamate[c] + NAD[c] YHR074W Nicotinate and nicotinamide metabolism +r_0769 NAD synthase ATP[n] + deamido-NAD(+)[n] + H2O[n] + L-glutamine[n] <=> AMP[n] + diphosphate[n] + H+[n] + L-glutamate[n] + NAD[n] YHR074W Nicotinate and nicotinamide metabolism +r_0770 NADH dehydrogenase, cytosolic/mitochondrial H+[c] + NADH[c] + ubiquinone-6[m] => NAD[c] + ubiquinol-6[m] YDL085W or YMR145C Oxidative phosphorylation +r_0771 NADH kinase ATP[c] + NADH[c] => ADP[c] + H+[c] + NADPH[c] YEL041W or YJR049C Nicotinate and nicotinamide metabolism +r_0772 NADH kinase mitochondrial ATP[m] + NADH[m] => ADP[m] + H+[m] + NADPH[m] YEL041W or YJR049C or YPL188W Nicotinate and nicotinamide metabolism +r_0773 NADH:ubiquinone oxidoreductase H+[m] + NADH[m] + ubiquinone-6[m] => NAD[m] + ubiquinol-6[m] YML120C Oxidative phosphorylation +r_0774 NAPRtase ATP[c] + H+[c] + nicotinate[c] + PRPP[c] => ADP[c] + diphosphate[c] + nicotinic acid D-ribonucleotide[c] + phosphate[c] YOR209C Nicotinate and nicotinamide metabolism +r_0775 NAPRtase ATP[m] + H+[m] + nicotinate[m] + PRPP[m] => ADP[m] + diphosphate[m] + nicotinic acid D-ribonucleotide[m] + phosphate[m] YOR209C Nicotinate and nicotinamide metabolism +r_0781 nicotinamidase H2O[c] + nicotinamide[c] => ammonium[c] + nicotinate[c] YGL037C Nicotinate and nicotinamide metabolism +r_0782 nicotinamide N-methyltransferase nicotinamide[c] + S-adenosyl-L-methionine[c] => 1-methylnicotinamide[c] + S-adenosyl-L-homocysteine[c] YLR285W Nicotinate and nicotinamide metabolism +r_0783 nicotinamide-nucleotide adenylyltransferase ATP[c] + H+[c] + NMN[c] => diphosphate[c] + NAD[c] YCL047C or YLR328W Nicotinate and nicotinamide metabolism +r_0784 nicotinamide-nucleotide adenylyltransferase ATP[n] + H+[n] + NMN[n] => diphosphate[n] + NAD[n] YGR010W or YLR328W Nicotinate and nicotinamide metabolism +r_0785 nicotinate-nucleotide adenylyltransferase ATP[c] + H+[c] + nicotinic acid D-ribonucleotide[c] => deamido-NAD(+)[c] + diphosphate[c] YGR010W or YLR328W Nicotinate and nicotinamide metabolism +r_0786 nicotinate-nucleotide diphosphorylase (carboxylating) 2 H+[c] + PRPP[c] + quinolinate[c] => carbon dioxide[c] + diphosphate[c] + nicotinic acid D-ribonucleotide[c] YFR047C Nicotinate and nicotinamide metabolism +r_0787 nicotinate-nucleotide diphosphorylase (carboxylating) 2 H+[m] + PRPP[m] + quinolinate[m] => carbon dioxide[m] + diphosphate[m] + nicotinic acid D-ribonucleotide[m] YFR047C Nicotinate and nicotinamide metabolism +r_0788 nucleoside diphosphatase ADP[c] + H2O[c] => AMP[c] + H+[c] + phosphate[c] YER005W Purine metabolism +r_0789 nucleoside diphosphatase GDP[c] + H2O[c] => GMP[c] + H+[c] + phosphate[c] YER005W Purine metabolism +r_0790 nucleoside diphosphatase H2O[c] + UDP[c] => H+[c] + phosphate[c] + UMP[c] YER005W Pyrimidine metabolism +r_0791 nucleoside diphosphatase H2O[g] + UDP[g] => H+[g] + phosphate[g] + UMP[g] YEL042W Pyrimidine metabolism +r_0792 nucleoside diphosphatase CDP[c] + H2O[c] => CMP[c] + H+[c] + phosphate[c] YER005W Pyrimidine metabolism +r_0793 nucleoside diphosphatase H2O[c] + IDP[c] => H+[c] + IMP[c] + phosphate[c] YER005W Purine metabolism +r_0795 nucleoside diphosphate kinase ATP[c] + CDP[c] => ADP[c] + CTP[c] YKL067W Pyrimidine metabolism +r_0796 nucleoside diphosphate kinase ATP[c] + dADP[c] => ADP[c] + dATP[c] YKL067W Purine metabolism +r_0797 nucleoside diphosphate kinase ATP[c] + dCDP[c] => ADP[c] + dCTP[c] YKL067W Pyrimidine metabolism +r_0798 nucleoside diphosphate kinase ATP[c] + dGDP[c] => ADP[c] + dGTP[c] YKL067W Purine metabolism +r_0799 nucleoside diphosphate kinase ATP[c] + dTDP[c] => ADP[c] + dTTP[c] YKL067W Pyrimidine metabolism +r_0800 nucleoside diphosphate kinase ATP[c] + GDP[c] => ADP[c] + GTP[c] YKL067W Purine metabolism +r_0801 nucleoside diphosphate kinase ATP[c] + IDP[c] => ADP[c] + ITP[c] YKL067W Purine metabolism +r_0802 nucleoside diphosphate kinase ATP[c] + dIDP[c] <=> ADP[c] + dITP[c] YKL067W Purine metabolism +r_0803 nucleoside diphosphate kinase ATP[c] + dUDP[c] <=> ADP[c] + dUTP[c] YKL067W Pyrimidine metabolism +r_0804 nucleoside triphosphatase GTP[c] + H2O[c] => GDP[c] + H+[c] + phosphate[c] YAL035W or YLL001W or YER005W Purine metabolism +r_0805 nucleoside triphosphatase H2O[c] + UTP[c] => H+[c] + phosphate[c] + UDP[c] YER005W Pyrimidine metabolism +r_0806 nucleoside triphosphatase CTP[c] + H2O[c] => CDP[c] + H+[c] + phosphate[c] YER005W Pyrimidine metabolism +r_0807 nucleoside triphosphatase H2O[c] + ITP[c] => H+[c] + IDP[c] + phosphate[c] YER005W Purine metabolism +r_0810 nucleoside-diphosphatase (GDP), Golgi GDP[g] + H2O[g] => GMP[g] + H+[g] + phosphate[g] YEL042W Purine metabolism +r_0811 nucleoside-diphosphate kinase (ATP:UDP) ATP[c] + UDP[c] => ADP[c] + UTP[c] YKL067W Pyrimidine metabolism +r_0812 O-acetylhomoserine (thiol)-lyase methanethiol[c] + O-acetyl-L-homoserine[c] => acetate[c] + H+[c] + L-methionine[c] YLR303W Cysteine and methionine metabolism +r_0813 O-acetylhomoserine (thiol)-lyase hydrogen sulfide[c] + O-acetyl-L-homoserine[c] => acetate[c] + L-homocysteine[c] YLR303W Cysteine and methionine metabolism +r_0815 O-succinylhomoserine lyase (L-cysteine) L-cysteine[c] + O-succinyl-L-homoserine[c] <=> H+[c] + L-cystathionine[c] + succinate[c] YLL058W or YML082W or YAL012W Cysteine and methionine metabolism +r_0816 ornithine carbamoyltransferase carbamoyl phosphate[c] + ornithine[c] => H+[c] + L-citrulline[c] + phosphate[c] YJL088W Arginine biosynthesis +r_0817 ornithine decarboxylase H+[c] + ornithine[c] => carbon dioxide[c] + putrescine[c] YKL184W Arginine and proline metabolism +r_0818 ornithine transacetylase L-glutamate[m] + N(2)-acetyl-L-ornithine[m] => N-acetyl-L-glutamate[m] + ornithine[m] YMR062C Arginine biosynthesis +r_0819 ornithine transaminase 2-oxoglutarate[c] + ornithine[c] => L-glutamate[c] + L-glutamic 5-semialdehyde[c] YLR438W Arginine and proline metabolism +r_0820 orotate phosphoribosyltransferase diphosphate[c] + orotidine 5'-(dihydrogen phosphate)[c] <=> orotate[c] + PRPP[c] YML106W or YMR271C Pyrimidine metabolism +r_0821 orotidine-5'-phosphate decarboxylase H+[c] + orotidine 5'-(dihydrogen phosphate)[c] => carbon dioxide[c] + UMP[c] YEL021W Pyrimidine metabolism +r_0831 oxoglutarate dehydrogenase (dihydrolipoamide S-succinyltransferase) coenzyme A[m] + S(8)-succinyldihydrolipoamide[m] => dihydrolipoamide[m] + succinyl-CoA[m] YDR148C and YFL018C and YIL125W Citrate cycle (TCA cycle) +r_0832 oxoglutarate dehydrogenase (lipoamide) 2-oxoglutarate[m] + H+[m] + lipoamide[m] => carbon dioxide[m] + S(8)-succinyldihydrolipoamide[m] YDR148C and YFL018C and YIL125W Citrate cycle (TCA cycle) +r_0841 pantetheine-phosphate adenylyltransferase ATP[c] + H+[c] + pantetheine 4'-phosphate[c] => 3'-dephospho-CoA[c] + diphosphate[c] YGR277C Pantothenate and coa biosynthesis +r_0842 pantothenate kinase (R)-pantothenate[c] + ATP[c] => (R)-4'-phosphopantothenic acid[c] + ADP[c] + H+[c] YDR531W Pantothenate and coa biosynthesis +r_0843 pantothenate synthase (R)-pantoate[c] + ATP[c] + beta-alanine[c] => (R)-pantothenate[c] + AMP[c] + diphosphate[c] + H+[c] YIL145C Pantothenate and coa biosynthesis +r_0844 peroxisomal acyl-CoA thioesterase decanoyl-CoA[p] + H2O[p] => coenzyme A[p] + decanoate[p] + H+[p] YJR019C Biosynthesis of unsaturated fatty acids +r_0845 peroxisomal acyl-CoA thioesterase H2O[p] + lauroyl-CoA[p] => coenzyme A[p] + H+[p] + laurate[p] YJR019C Biosynthesis of unsaturated fatty acids +r_0847 peroxisomal acyl-CoA thioesterase H2O[p] + palmitoyl-CoA[p] => coenzyme A[p] + H+[p] + palmitate[p] YJR019C Biosynthesis of unsaturated fatty acids +r_0848 peroxisomal acyl-CoA thioesterase H2O[p] + myristoyl-CoA[p] => coenzyme A[p] + H+[p] + myristate[p] YJR019C Biosynthesis of unsaturated fatty acids +r_0849 peroxisomal acyl-CoA thioesterase H2O[p] + stearoyl-CoA[p] => coenzyme A[p] + H+[p] + stearate[p] YJR019C Biosynthesis of unsaturated fatty acids +r_0850 peroxisomal acyl-CoA thioesterase H2O[p] + octanoyl-CoA[p] => coenzyme A[p] + H+[p] + octanoate[p] YJR019C Biosynthesis of unsaturated fatty acids +r_0851 phenylalanine transaminase 2-oxoglutarate[c] + L-phenylalanine[c] <=> keto-phenylpyruvate[c] + L-glutamate[c] YGL202W Phenylalanine, tyrosine and tryptophan biosynthesis +r_0852 phenylalanyl-tRNA synthetase ATP[c] + L-phenylalanine[c] + tRNA(Phe)[c] => AMP[c] + diphosphate[c] + Phe-tRNA(Phe)[c] YFL022C and YLR060W tRNA metabolism https://www.yeastgenome.org/go/GO:0006399 +r_0853 phenylalanyl-tRNA synthetase ATP[m] + L-phenylalanine[m] + tRNA(Phe)[m] => AMP[m] + diphosphate[m] + Phe-tRNA(Phe)[m] YPR047W tRNA metabolism https://www.yeastgenome.org/go/GO:0006399 +r_0854 phenylpyruvate decarboxylase H+[c] + keto-phenylpyruvate[c] => carbon dioxide[c] + phenylacetaldehyde[c] YDR380W Phenylalanine metabolism +r_0855 phopshoribosylaminoimidazole synthetase 5'-phosphoribosyl-N-formylglycineamidine[c] + ATP[c] => 5'-phosphoribosyl-5-aminoimidazole[c] + ADP[c] + H+[c] + phosphate[c] YGL234W Purine metabolism +r_0882 phosphoacetylglucosamine mutase N-acetyl-D-glucosamine 6-phosphate[c] <=> N-acetyl-alpha-D-glucosamine 1-phosphate[c] YEL058W Amino sugar and nucleotide sugar metabolism +r_0883 phosphoadenylyl-sulfate reductase (thioredoxin) 3'-phospho-5'-adenylyl sulfate[c] + TRX1[c] => adenosine 3',5'-bismonophosphate[c] + H+[c] + sulphite[c] + TRX1 disulphide[c] (YGR209C and YPR167C) or (YLR043C and YPR167C) Sulfur metabolism +r_0884 phosphoenolpyruvate carboxykinase ATP[c] + oxaloacetate[c] => ADP[c] + carbon dioxide[c] + phosphoenolpyruvate[c] YKR097W Glycolysis / gluconeogenesis +r_0885 phosphoethanolamine cytidyltransferase CTP[c] + H+[c] + O-phosphoethanolamine[c] => CDP-ethanolamine[c] + diphosphate[c] YGR007W Glycerophospholipid metabolism +r_0886 phosphofructokinase ATP[c] + D-fructose 6-phosphate[c] => ADP[c] + D-fructose 1,6-bisphosphate[c] + H+[c] YMR205C or (YGR240C and YMR205C) Glycolysis / gluconeogenesis +r_0887 phosphofructokinase (s7p) ATP[c] + sedoheptulose 7-phosphate[c] => ADP[c] + H+[c] + sedoheptulose 1,7-bisphosphate[c] YMR205C or (YGR240C and YMR205C) Glycolysis / gluconeogenesis +r_0888 phosphoglucomutase D-glucose 6-phosphate[c] <=> D-glucose 1-phosphate[c] YMR105C or YKL127W Pentose phosphate pathway +r_0889 phosphogluconate dehydrogenase 6-phospho-D-gluconate[c] + NADP(+)[c] => carbon dioxide[c] + D-ribulose 5-phosphate[c] + NADPH[c] YGR256W or YHR183W Pentose phosphate pathway +r_0890 phosphoglucosamine mutase alpha-D-glucosamine 1-phosphate[c] <=> alpha-D-glucosamine 6-phosphate[c] YEL058W Amino sugar and nucleotide sugar metabolism +r_0891 phosphoglycerate dehydrogenase 3-phosphonato-D-glycerate(3-)[c] + NAD[c] => 3-phospho-hydroxypyruvate[c] + H+[c] + NADH[c] YER081W or YIL074C Glycine, serine and threonine metabolism +r_0892 phosphoglycerate kinase 1,3-bisphospho-D-glycerate[c] + ADP[c] <=> 3-phosphonato-D-glycerate(3-)[c] + ATP[c] YCR012W Glycolysis / gluconeogenesis +r_0893 phosphoglycerate mutase 3-phosphonato-D-glycerate(3-)[c] <=> 2-phospho-D-glyceric acid[c] YOR283W or YKL152C Glycolysis / gluconeogenesis +r_0902 phosphomannomutase D-mannose 1-phosphate[c] <=> D-mannose 6-phosphate[c] YFL045C Fructose and mannose metabolism +r_0903 phosphomethylpyrimidine kinase 4-amino-2-methyl-5-phosphomethylpyrimidine[c] + ATP[c] => 4-amino-2-methyl-5-diphosphomethylpyrimidine[c] + ADP[c] YOL055C or YPL258C or YPR121W Thiamine metabolism +r_0904 phosphomevalonate kinase (R)-5-phosphomevalonic acid[c] + ATP[c] => (R)-5-diphosphomevalonic acid[c] + ADP[c] YMR220W Terpenoid backbone biosynthesis +r_0905 phosphopantothenate-cysteine ligase (R)-4'-phosphopantothenic acid[c] + CTP[c] + L-cysteine[c] => CMP[c] + diphosphate[c] + H+[c] + N-[(R)-4-phosphonopantothenoyl]-L-cysteine[c] YIL083C Pantothenate and coa biosynthesis +r_0906 phosphopantothenoylcysteine decarboxylase H+[c] + N-[(R)-4-phosphonopantothenoyl]-L-cysteine[c] => carbon dioxide[c] + pantetheine 4'-phosphate[c] (YKL088W and YKR072C and YOR054C) or (YKL088W and YKR072C) or (YKL088W and YOR054C) or YKL088W Pantothenate and coa biosynthesis +r_0907 phosphopentomutase alpha-D-ribose 1-phosphate(2-)[c] <=> ribose-5-phosphate[c] YKL127W or YMR105C or YMR278W Pentose phosphate pathway +r_0908 phosphoribosyl amino imidazolesuccinocarbozamide synthetase ATP[c] + L-aspartate[c] + phosphoribosyl-carboxy-aminoimidazole[c] => 5'-phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole[c] + ADP[c] + 2 H+[c] + phosphate[c] YAR015W Purine metabolism +r_0909 phosphoribosyl-AMP cyclohydrolase 1-(5-phosphoribosyl)-5'-AMP[c] + H2O[c] => 1-(5-phospho-D-ribosyl)-5-[(5-phospho-D-ribosylamino)methylideneamino]imidazole-4-carboxamide[c] YCL030C Histidine metabolism +r_0910 phosphoribosyl-ATP pyrophosphatase 5-phosphoribosyl-ATP[c] + H2O[c] => 1-(5-phosphoribosyl)-5'-AMP[c] + diphosphate[c] + H+[c] YCL030C Histidine metabolism +r_0911 phosphoribosylaminoimidazole-carboxylase 5'-phosphoribosyl-5-aminoimidazole[c] + carbon dioxide[c] => H+[c] + phosphoribosyl-carboxy-aminoimidazole[c] YOR128C Purine metabolism +r_0912 phosphoribosylaminoimidazolecarboxamide formyltransferase 10-formyl-THF[c] + AICAR[c] <=> phosphoribosyl-formamido-carboxamide[c] + THF[c] YLR028C or YMR120C Purine metabolism +r_0913 phosphoribosylanthranilate isomerase N-(5-phospho-beta-D-ribosyl)anthranilate[c] => 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate[c] YDR007W Phenylalanine, tyrosine and tryptophan biosynthesis +r_0914 phosphoribosylglycinamidine synthetase 5-phosphoribosylamine[c] + ATP[c] + L-glycine[c] => 5-phospho-ribosyl-glycineamide[c] + ADP[c] + H+[c] + phosphate[c] YGL234W Purine metabolism +r_0915 phosphoribosylpyrophosphate amidotransferase H2O[c] + L-glutamine[c] + PRPP[c] => 5-phosphoribosylamine[c] + diphosphate[c] + L-glutamate[c] YMR300C Purine metabolism +r_0916 phosphoribosylpyrophosphate synthetase ATP[c] + ribose-5-phosphate[c] => AMP[c] + H+[c] + PRPP[c] (YKL181W and YER099C) or (YKL181W and YHL011C) or (YKL181W and YBL068W) or (YER099C and YOL061W) or (YBL068W and YOL061W) Pentose phosphate pathway +r_0917 phosphoserine phosphatase (L-serine) 3-phospho-serine[c] + H2O[c] => L-serine[c] + phosphate[c] YGR208W Glycine, serine and threonine metabolism +r_0918 phosphoserine transaminase 3-phospho-hydroxypyruvate[c] + L-glutamate[c] => 2-oxoglutarate[c] + 3-phospho-serine[c] YOR184W Glycine, serine and threonine metabolism +r_0919 phytoceramidase lignoceric acid[er] + phytosphingosine[er] => ceramide-2 (C24)[er] + H2O[er] YBR183W Sphingolipid metabolism +r_0920 phytoceramidase cerotic acid[er] + phytosphingosine[er] => ceramide-2 (C26)[er] + H2O[er] YDR402C Tryptophan metabolism +r_0921 Phytosphingosine phosphate lyase phytosphingosine 1-phosphate[er] => 2-hydroxyhexadecanal[er] + O-phosphoethanolamine[er] YDR294C Sphingolipid metabolism +r_0922 phytosphingosine synthesis H+[er] + NADPH[er] + oxygen[er] + sphinganine[er] => H2O[er] + NADP(+)[er] + phytosphingosine[er] YDR297W Sphingolipid metabolism +r_0929 polyamine oxidase H2O[c] + N(1)-acetylspermidine[c] + oxygen[c] => 3-aminopropanal[c] + hydrogen peroxide[c] + N-acetylputrescine[c] YMR020W Arginine and proline metabolism +r_0935 porphobilinogen synthase 2 5-aminolevulinate[c] => H+[c] + 2 H2O[c] + porphobilinogen[c] YGL040C Porphyrin and chlorophyll metabolism +r_0936 poylamine oxidase H2O[c] + N(1)-acetylspermine[c] + oxygen[c] => 3-aminopropanal[c] + hydrogen peroxide[c] + N(1)-acetylspermidine[c] YMR020W Arginine and proline metabolism +r_0937 poylamine oxidase H2O[c] + oxygen[c] + spermine[c] => 3-aminopropanal[c] + hydrogen peroxide[c] + spermidine[c] YMR020W Arginine and proline metabolism +r_0938 prephenate dehydratase H+[c] + prephenate[c] => carbon dioxide[c] + H2O[c] + keto-phenylpyruvate[c] YNL316C Phenylalanine, tyrosine and tryptophan biosynthesis +r_0939 prephenate dehydrogenase (NADP) NADP(+)[c] + prephenate[c] => 3-(4-hydroxyphenyl)pyruvate[c] + carbon dioxide[c] + NADPH[c] YBR166C Phenylalanine, tyrosine and tryptophan biosynthesis +r_0940 proline oxidase (NAD) FAD[m] + L-proline[m] => 1-pyrroline-5-carboxylate[m] + FADH2[m] YLR142W Arginine and proline metabolism +r_0941 prolyl-tRNA synthetase ATP[c] + L-proline[c] + tRNA(Pro)[c] => AMP[c] + diphosphate[c] + Pro-tRNA(Pro)[c] YHR020W tRNA metabolism https://www.yeastgenome.org/go/GO:0006399 +r_0942 protoporphyrinogen oxidase 3 oxygen[m] + 2 protoporphyrinogen[m] => 6 H2O[m] + 2 protoporphyrin[m] YER014W Porphyrin and chlorophyll metabolism +r_0943 purine-nucleoside phosphorylase nicotinamide riboside[c] + phosphate[c] => alpha-D-ribose 1-phosphate(2-)[c] + H+[c] + nicotinamide[c] YDR400W and YLR017W and YLR209C Nicotinate and nicotinamide metabolism +r_0949 guanosine phosphorylase guanosine[c] + phosphate[c] <=> alpha-D-ribose 1-phosphate(2-)[c] + guanine[c] YLR209C Purine metabolism +r_0950 guanosine phosphorylase guanosine[m] + phosphate[m] <=> alpha-D-ribose 1-phosphate(2-)[m] + guanine[m] YLR209C Purine metabolism +r_0951 inosine phosphorylase inosine[c] + phosphate[c] <=> alpha-D-ribose 1-phosphate(2-)[c] + hypoxanthine[c] YLR209C Purine metabolism +r_0953 pyridoxal oxidase ammonium[c] + 2 H2O[c] + 0.5 oxygen[c] + pyridoxal[c] => 2 hydrogen peroxide[c] + pyridoxamine[c] YBR035C Vitamin b6 metabolism +r_0954 pyridoxamine 5'-phosphate oxidase H2O[c] + oxygen[c] + pyridoxamine 5'-phosphate[c] => ammonium[c] + hydrogen peroxide[c] + pyridoxal 5'-phosphate[c] YBR035C Vitamin b6 metabolism +r_0955 pyridoxine 5'-phosphate oxidase oxygen[c] + pyridoxine 5'-phosphate[c] => hydrogen peroxide[c] + pyridoxal 5'-phosphate[c] YBR035C Vitamin b6 metabolism +r_0956 pyridoxine oxidase oxygen[c] + pyridoxine[c] => hydrogen peroxide[c] + pyridoxal[c] YBR035C Vitamin b6 metabolism +r_0957 pyrroline-5-carboxylate reductase 1-pyrroline-5-carboxylate[c] + 2 H+[c] + NADPH[c] => L-proline[c] + NADP(+)[c] YER023W Arginine and proline metabolism +r_0958 pyruvate carboxylase ATP[c] + bicarbonate[c] + pyruvate[c] => ADP[c] + H+[c] + oxaloacetate[c] + phosphate[c] YBR218C or YGL062W Pyruvate metabolism +r_0959 pyruvate decarboxylase H+[c] + pyruvate[c] => acetaldehyde[c] + carbon dioxide[c] YGR087C or YLR044C or YLR134W Glycolysis / gluconeogenesis +r_0960 pyruvate decarboxylase (acetoin-forming) acetaldehyde[c] + H+[c] + pyruvate[c] => (R)-acetoin[c] + carbon dioxide[c] YGR087C or YLR044C or YLR134W Glycolysis / gluconeogenesis +r_0961 pyruvate dehydrogenase coenzyme A[m] + NAD[m] + pyruvate[m] => acetyl-CoA[m] + carbon dioxide[m] + NADH[m] YBR221C and YER178W and YFL018C and YGR193C and YNL071W Glycolysis / gluconeogenesis +r_0962 pyruvate kinase ADP[c] + H+[c] + phosphoenolpyruvate[c] => ATP[c] + pyruvate[c] YAL038W or YOR347C Glycolysis / gluconeogenesis +r_0963 quinone oxidoreductase 2-hexaprenyl-6-methoxy-3-methyl-1,4-benzoquinone[m] + H+[m] + NADH[m] + oxygen[m] => 2-hexaprenyl-5-hydroxy-6-methoxy-3-methyl-1,4-benzoquinone[m] + H2O[m] + NAD[m] YDR204W and YGL119W and YGR255C and YLR201C and YML110C and YOL096C and YOR125C Ubiquinone and other terpenoid-quinone biosynthesis +r_0964 reduced glutathione via ABC system ATP[c] + glutathione[c] + H2O[c] => ADP[c] + glutathione[v] + H+[c] + phosphate[c] YDR135C Transport [c, v] +r_0965 riboflavin kinase ATP[c] + riboflavin[c] => ADP[c] + FMN[c] + H+[c] YDR236C Riboflavin metabolism +r_0966 riboflavin kinase ATP[m] + riboflavin[m] => ADP[m] + FMN[m] + H+[m] YDR236C Riboflavin metabolism +r_0967 riboflavin synthase 2-hydroxy-3-oxobutyl phosphate[c] + 5-amino-6-(D-ribitylamino)uracil[c] => 6,7-dimethyl-8-(1-D-ribityl)lumazine[c] + H+[c] + 2 H2O[c] + phosphate[c] YOL143C Riboflavin metabolism +r_0968 riboflavin synthase 2 6,7-dimethyl-8-(1-D-ribityl)lumazine[c] + H+[c] => 5-amino-6-(D-ribitylamino)uracil[c] + riboflavin[c] YBR256C Riboflavin metabolism +r_0969 ribokinase ATP[c] + D-ribose[c] => ADP[c] + H+[c] + ribose-5-phosphate[c] YCR036W Pentose phosphate pathway +r_0970 ribonucleoside-triphosphate reductase (ATP) ATP[c] + H+[c] + TRX1[c] => dATP[c] + H2O[c] + TRX1 disulphide[c] YGR209C Purine metabolism +r_0971 ribonucleoside-triphosphate reductase (CTP) CTP[c] + H+[c] + TRX1[c] => dCTP[c] + H2O[c] + TRX1 disulphide[c] YGR209C Pyrimidine metabolism +r_0972 ribonucleoside-triphosphate reductase (GTP) GTP[c] + H+[c] + TRX1[c] => dGTP[c] + H2O[c] + TRX1 disulphide[c] YGR209C Purine metabolism +r_0973 ribonucleoside-triphosphate reductase (UTP) H+[c] + UTP[c] + TRX1[c] => dUTP[c] + H2O[c] + TRX1 disulphide[c] YGR209C Pyrimidine metabolism +r_0974 ribonucleotide reductase ADP[c] + H+[c] + TRX1[c] => dADP[c] + H2O[c] + TRX1 disulphide[c] YER070W or YGR180C or YIL066C or YJL026W Purine metabolism +r_0975 ribonucleotide reductase ADP[n] + H+[n] + TRX1[n] => dADP[n] + H2O[n] + TRX1 disulphide[n] YER070W or YGR180C or YIL066C or YJL026W Purine metabolism +r_0976 ribonucleotide reductase CDP[c] + H+[c] + TRX1[c] => dCDP[c] + H2O[c] + TRX1 disulphide[c] YER070W or YGR180C or YIL066C or YJL026W Pyrimidine metabolism +r_0977 ribonucleotide reductase CDP[n] + H+[n] + TRX1[n] => dCDP[n] + H2O[n] + TRX1 disulphide[n] YER070W or YGR180C or YIL066C or YJL026W Pyrimidine metabolism +r_0978 ribonucleotide reductase GDP[c] + H+[c] + TRX1[c] => dGDP[c] + H2O[c] + TRX1 disulphide[c] YER070W or YGR180C or YIL066C or YJL026W Purine metabolism +r_0979 ribonucleotide reductase GDP[n] + H+[n] + TRX1[n] => dGDP[n] + H2O[n] + TRX1 disulphide[n] YER070W or YGR180C or YIL066C or YJL026W Purine metabolism +r_0982 ribose-5-phosphate isomerase D-ribulose 5-phosphate[c] <=> ribose-5-phosphate[c] YOR095C Pentose phosphate pathway +r_0983 ribosylnicotinamide kinase ATP[c] + nicotinamide riboside[c] => ADP[c] + H+[c] + NMN[c] YNL129W Nicotinate and nicotinamide metabolism +r_0984 ribulose 5-phosphate 3-epimerase D-ribulose 5-phosphate[c] <=> D-xylulose 5-phosphate[c] YJL121C Pentose phosphate pathway +r_0985 S-adenosyl-L-methionine:3-hexaprenyl-4,5-dihydroxylate O-methyltransferase 3-hexaprenyl-4,5-dihydroxybenzoic acid[m] + S-adenosyl-L-methionine[m] => 3-hexaprenyl-4-hydroxy-5-methoxybenzoic acid[m] + H+[m] + S-adenosyl-L-homocysteine[m] YDR204W and YGL119W and YGR255C and YLR201C and YML110C and YOL096C and YOR125C Ubiquinone and other terpenoid-quinone biosynthesis +r_0986 S-adenosyl-methionine delta-24-sterol-c-methyltransferase S-adenosyl-L-methionine[c] + zymosterol[c] => fecosterol[c] + H+[c] + S-adenosyl-L-homocysteine[c] YML008C Steroid biosynthesis +r_0987 S-formylglutathione hydralase H2O[c] + S-formylglutathione[c] => formate[c] + glutathione[c] + H+[c] YJL068C Alternate carbon metabolism +r_0988 saccharopine dehydrogenase (NAD, L-lysine forming) H2O[c] + L-saccharopine[c] + NAD[c] => 2-oxoglutarate[c] + H+[c] + L-lysine[c] + NADH[c] YIR034C Lysine metabolism +r_0989 saccharopine dehydrogenase (NADP, L-glutamate forming) H+[c] + L-allysine[c] + L-glutamate[c] + NADPH[c] => H2O[c] + L-saccharopine[c] + NADP(+)[c] YNR050C Lysine metabolism +r_0990 sedoheptulose 1,7-bisphosphate D-glyceraldehyde-3-phosphate-lyase sedoheptulose 1,7-bisphosphate[c] <=> D-erythrose 4-phosphate[c] + dihydroxyacetone phosphate[c] YKL060C Glycolysis / gluconeogenesis +r_0992 serine O-acetyltransferase acetyl-CoA[c] + L-serine[c] => coenzyme A[c] + O-acetyl-L-serine[c] (YDL040C and YGR147C and YHR013C) or (YDL040C and YGR147C) Cysteine and methionine metabolism +r_0993 serine palmitotransferase H+[er] + L-serine[er] + palmitoyl-CoA[er] => 3-ketosphinganine[er] + carbon dioxide[er] + coenzyme A[er] (YBR058C-A and YDR062W and YMR296C) or (YDR062W and YMR296C) Sphingolipid metabolism +r_0995 seryl-tRNA synthetase ATP[c] + L-serine[c] + tRNA(Ser)[c] => AMP[c] + diphosphate[c] + Ser-tRNA(Ser)[c] YDR023W or YHR011W tRNA metabolism https://www.yeastgenome.org/go/GO:0006399 +r_0996 shikimate dehydrogenase 3-dehydroshikimate[c] + H+[c] + NADPH[c] => NADP(+)[c] + shikimate[c] YDR127W Phenylalanine, tyrosine and tryptophan biosynthesis +r_0997 shikimate kinase ATP[c] + shikimate[c] => 3-phosphoshikimic acid[c] + ADP[c] + H+[c] YDR127W Phenylalanine, tyrosine and tryptophan biosynthesis +r_0998 sirohydrochlorin dehydrogenase NAD[c] + precorrin-2[c] => 2 H+[c] + NADH[c] + sirohydrochlorin[c] YBR213W Porphyrin and chlorophyll metabolism +r_0999 sirohydrochlorin ferrochetalase iron(2+)[c] + sirohydrochlorin[c] => 2 H+[c] + siroheme[c] YBR213W Porphyrin and chlorophyll metabolism +r_1000 fumarate reductase (FMN) FMNH2[c] + fumarate[c] <=> FMN[c] + H+[c] + succinate[c] YEL047C Cellular response to anaerobic conditions https://www.yeastgenome.org/go/GO:0071454 +r_1001 spermidine synthase putrescine[c] + S-adenosylmethioninamine[c] => 5'-S-methyl-5'-thioadenosine[c] + H+[c] + spermidine[c] YPR069C Arginine and proline metabolism +r_1002 spermine synthase S-adenosylmethioninamine[c] + spermidine[c] => 5'-S-methyl-5'-thioadenosine[c] + H+[c] + spermine[c] YLR146C Arginine and proline metabolism +r_1003 sphinganine phosphate lyase sphinganine 1-phosphate[er] => hexadecanal[er] + O-phosphoethanolamine[er] YDR294C Sphingolipid metabolism +r_1004 sphingoid base-phosphate phosphatase (phytosphingosine 1-phosphate) H2O[er] + phytosphingosine 1-phosphate[er] => phosphate[er] + phytosphingosine[er] YJL134W or YKR053C Sphingolipid metabolism +r_1005 sphingoid base-phosphate phosphatase (sphinganine 1-phosphatase) H2O[er] + sphinganine 1-phosphate[er] => phosphate[er] + sphinganine[er] YJL134W or YKR053C Sphingolipid metabolism +r_1006 sphingolipid long chain base kinase (phytosphingosine) ATP[er] + phytosphingosine[er] => ADP[er] + H+[er] + phytosphingosine 1-phosphate[er] YLR260W or YOR171C Sphingolipid metabolism +r_1007 sphingolipid long chain base kinase (sphinganine) ATP[er] + sphinganine[er] => ADP[er] + H+[er] + sphinganine 1-phosphate[er] YLR260W or YOR171C Sphingolipid metabolism +r_1008 spontaneous cis-aconitate(3-) to trans-aconitate cis-aconitate[m] <=> trans-aconitate[m] C5-branched dibasic acid metabolism +r_1009 spontaneous cis-aconitate(3-) to trans-aconitate cis-aconitate[c] <=> trans-aconitate[c] C5-branched dibasic acid metabolism +r_1010 squalene epoxidase (NAD) H+[er] + NADH[er] + oxygen[er] + squalene[er] => (S)-2,3-epoxysqualene[er] + H2O[er] + NAD[er] YGR175C Steroid biosynthesis +r_1011 squalene epoxidase (NADP) H+[er] + NADPH[er] + oxygen[er] + squalene[er] => (S)-2,3-epoxysqualene[er] + H2O[er] + NADP(+)[er] YGR175C Steroid biosynthesis +r_1012 squalene synthase 2 farnesyl diphosphate[c] + H+[c] + NADPH[c] => 2 diphosphate[c] + NADP(+)[c] + squalene[c] YHR190W Steroid biosynthesis +r_1021 succinate dehydrogenase (ubiquinone-6) succinate[m] + ubiquinone-6[m] <=> fumarate[m] + ubiquinol-6[m] (YDR178W and YJL045W and YKL141W and YLL041C) or (YDR178W and YKL141W and YKL148C and YLL041C) or (YLR164W and YJL045W and YKL141W and YLL041C) Citrate cycle (TCA cycle) +r_1022 succinate-CoA ligase (ADP-forming) ADP[m] + phosphate[m] + succinyl-CoA[m] => ATP[m] + coenzyme A[m] + succinate[m] YGR244C and YOR142W Citrate cycle (TCA cycle) +r_1023 succinate-semialdehyde dehydrogenase (NADP) H2O[c] + NADP(+)[c] + succinic semialdehyde[c] => 2 H+[c] + NADPH[c] + succinate[c] YBR006W Alanine, aspartate and glutamate metabolism +r_1024 sucrose hydrolyzing enxyme H2O[e] + sucrose[e] => D-fructose[e] + D-glucose[e] YIL162W Starch and sucrose metabolism +r_1025 sulfate adenylyltransferase ATP[c] + H+[c] + sulphate[c] => 5'-adenylyl sulfate[c] + diphosphate[c] YJR010W Sulfur metabolism +r_1026 sulfate adenylyltransferase (ADP) ADP[c] + H+[c] + sulphate[c] => 5'-adenylyl sulfate[c] + phosphate[c] YCL050C Sulfur metabolism +r_1027 sulfite reductase (NADPH2) 4 H+[c] + 3 NADPH[c] + sulphite[c] => 3 H2O[c] + hydrogen sulfide[c] + 3 NADP(+)[c] YFR030W and YJR137C Sulfur metabolism +r_1028 taurcholate via ABC system ATP[c] + H2O[c] + taurocholic acid[c] => ADP[c] + H+[c] + phosphate[c] + taurocholic acid[v] YLL048C Transport [c, v] +r_1029 taurine dioxygenase 2-oxoglutarate[c] + oxygen[c] + taurine[c] => aminoacetaldehyde[c] + carbon dioxide[c] + H+[c] + succinate[c] + sulphite[c] YLL057C Sulfur metabolism +r_1030 tetrahydrofolate aminomethyltransferase 5,10-methenyl-THF[m] + H2O[m] => 5-formyltetrahydrofolic acid[m] + H+[m] YAL044C and YDR019C and YFL018C and YMR189W One carbon pool by folate +r_1031 tetrahydrofolate:L-glutamate gamma-ligase (ADP-forming) ATP[c] + L-glutamate[c] + THF[c] <=> 5,6,7,8-tetrahydrofolyl-L-glutamic acid[c] + ADP[c] + H+[c] + phosphate[c] YKL132C or YOR241W Folate biosynthesis +r_1032 thiamin diphosphatase 2 H2O[e] + TDP[e] => H+[e] + 2 phosphate[e] + thiamine[e] YBR092C Thiamine metabolism +r_1033 thiamin phosphatase H2O[e] + TMP[e] => phosphate[e] + thiamine[e] YBR092C Thiamine metabolism +r_1034 thiamine diphosphokinase ATP[c] + thiamine[c] => AMP[c] + H+[c] + TDP[c] YOR143C Thiamine metabolism +r_1035 thiamine-diphosphate kinase ATP[c] + TDP[c] => ADP[c] + thiamine(1+) triphosphate(4-)[c] YOR143C Thiamine metabolism +r_1036 thiamine-phosphate diphosphorylase 4-amino-2-methyl-5-diphosphomethylpyrimidine[c] + 4-methyl-5-(2-phosphonooxyethyl)thiazole[c] + H+[c] => diphosphate[c] + TMP[c] YPL214C Thiamine metabolism +r_1037 thioredoxin H+[n] + hydrogen peroxide[n] + TRX1[n] => 2 H2O[n] + TRX1 disulphide[n] (YGR209C and YIL010W) or (YIL010W and YLR043C) Glutathione metabolism +r_1038 thioredoxin reductase (NADPH) NADPH[c] + TRX1 disulphide[c] => NADP(+)[c] + TRX1[c] (YDR353W and YGR209C) or (YDR353W and YLR043C) or YDR353W Glutathione metabolism +r_1039 thioredoxin reductase (NADPH) NADPH[m] + TRX1 disulphide[m] => NADP(+)[m] + TRX1[m] (YCR083W and YHR106W) or (YCR083W and YPL091W) Glutathione metabolism +r_1040 threonine aldolase L-threonine[c] => acetaldehyde[c] + L-glycine[c] YEL046C Glycine, serine and threonine metabolism +r_1041 threonine synthase H2O[c] + O-phospho-L-homoserine[c] => L-threonine[c] + phosphate[c] YCR053W Glycine, serine and threonine metabolism +r_1042 threonyl-tRNA synthetase ATP[c] + L-threonine[c] + tRNA(Thr)[c] => AMP[c] + diphosphate[c] + Thr-tRNA(Thr)[c] YIL078W tRNA metabolism https://www.yeastgenome.org/go/GO:0006399 +r_1043 threonyl-tRNA synthetase ATP[m] + L-threonine[m] + tRNA(Thr)[m] => AMP[m] + diphosphate[m] + Thr-tRNA(Thr)[m] YKL194C tRNA metabolism https://www.yeastgenome.org/go/GO:0006399 +r_1045 thymidylate synthase 5,10-methylenetetrahydrofolate[c] + dUMP[c] => dihydrofolic acid[c] + dTMP[c] YOR074C Pyrimidine metabolism +r_1046 trans-aconitate 3-methyltransferase S-adenosyl-L-methionine[c] + trans-aconitate[c] => (2E)-3-(methoxycarbonyl)pent-2-enedioic acid[c] + S-adenosyl-L-homocysteine[c] YER175C C5-branched dibasic acid metabolism r_1009 +r_1047 trans-pentaprenyltranstransferase isopentenyl diphosphate[m] + pentaprenyl diphosphate[m] => diphosphate[m] + hexaprenyl diphosphate[m] YBR003W Terpenoid backbone biosynthesis +r_1048 transaldolase glyceraldehyde 3-phosphate[c] + sedoheptulose 7-phosphate[c] <=> D-erythrose 4-phosphate[c] + D-fructose 6-phosphate[c] YGR043C or YLR354C Pentose phosphate pathway +r_1049 transketolase 1 D-xylulose 5-phosphate[c] + ribose-5-phosphate[c] <=> glyceraldehyde 3-phosphate[c] + sedoheptulose 7-phosphate[c] YBR117C or YPR074C Pentose phosphate pathway +r_1050 transketolase 2 D-erythrose 4-phosphate[c] + D-xylulose 5-phosphate[c] <=> D-fructose 6-phosphate[c] + glyceraldehyde 3-phosphate[c] YBR117C or YPR074C Pentose phosphate pathway +r_1051 trehalose-phosphatase alpha,alpha-trehalose 6-phosphate[c] + H2O[c] => phosphate[c] + trehalose[c] (YBR126C and YDR074W and YML100W) or (YBR126C and YDR074W and YMR261C) Starch and sucrose metabolism +r_1054 triose-phosphate isomerase dihydroxyacetone phosphate[c] <=> glyceraldehyde 3-phosphate[c] YDR050C Glycolysis / gluconeogenesis +r_1055 tryptophan synthase (indoleglycerol phosphate) 1-C-(indol-3-yl)glycerol 3-phosphate[c] + L-serine[c] => glyceraldehyde 3-phosphate[c] + H2O[c] + L-tryptophan[c] YGL026C Phenylalanine, tyrosine and tryptophan biosynthesis +r_1056 tryptophan transaminase 2-oxoglutarate[c] + L-tryptophan[c] => indole-3-pyruvate[c] + L-glutamate[c] YGL202W Phenylalanine, tyrosine and tryptophan biosynthesis +r_1057 tryptophanyl-tRNA synthetase ATP[c] + L-tryptophan[c] + tRNA(Trp)[c] => AMP[c] + diphosphate[c] + Trp-tRNA(Trp)[c] YOL097C tRNA metabolism https://www.yeastgenome.org/go/GO:0006399 +r_1058 tryptophanyl-tRNA synthetase ATP[m] + L-tryptophan[m] + tRNA(Trp)[m] => AMP[m] + diphosphate[m] + Trp-tRNA(Trp)[m] YDR268W tRNA metabolism https://www.yeastgenome.org/go/GO:0006399 +r_1063 tyrosine transaminase 3-(4-hydroxyphenyl)pyruvate[c] + L-glutamate[c] <=> 2-oxoglutarate[c] + L-tyrosine[c] YGL202W Tyrosine metabolism +r_1065 tyrosine transaminase 3-(4-hydroxyphenyl)pyruvate[p] + L-glutamate[p] => 2-oxoglutarate[p] + L-tyrosine[p] YLR027C Tyrosine metabolism +r_1066 tyrosyl-tRNA synthetase ATP[c] + L-tyrosine[c] + tRNA(Tyr)[c] => AMP[c] + diphosphate[c] + Tyr-tRNA(Tyr)[c] YGR185C tRNA metabolism https://www.yeastgenome.org/go/GO:0006399 +r_1067 tyrosyl-tRNA synthetase ATP[m] + L-tyrosine[m] + tRNA(Tyr)[m] => AMP[m] + diphosphate[m] + Tyr-tRNA(Tyr)[m] YPL097W tRNA metabolism https://www.yeastgenome.org/go/GO:0006399 +r_1068 UDP-glucose:ergosterol glucosyltransferase ergosterol[c] + UDP-D-glucose[c] => ergosterol 3-beta-D-glucoside[c] + H+[c] + UDP[c] YLR189C Steroid biosynthesis r_3252 +r_1069 UDP-N-acetylglucosamine diphosphorylase H+[c] + N-acetyl-alpha-D-glucosamine 1-phosphate[c] + UTP[c] <=> diphosphate[c] + UDP-N-acetyl-alpha-D-glucosamine[c] YDL103C Amino sugar and nucleotide sugar metabolism +r_1070 UDPglucose 4-epimerase UDP-D-glucose[c] <=> UDP-D-galactose[c] YBR019C Galactose metabolism +r_1071 UDPglucose--hexose-1-phosphate uridylyltransferase alpha-D-galactose 1-phosphate[c] + UDP-D-glucose[c] <=> D-glucose 1-phosphate[c] + UDP-D-galactose[c] YBR018C Galactose metabolism +r_1072 UMP kinase ATP[c] + UMP[c] => ADP[c] + UDP[c] YKL024C Pyrimidine metabolism +r_1073 UMP kinase ATP[n] + UMP[n] => ADP[n] + UDP[n] YKL024C Pyrimidine metabolism +r_1074 uracil phosphoribosyltransferase PRPP[c] + uracil[c] => diphosphate[c] + UMP[c] YHR128W Pyrimidine metabolism +r_1075 urea carboxylase ATP[c] + bicarbonate[c] + urea[c] => ADP[c] + H+[c] + phosphate[c] + urea-1-carboxylic acid[c] YBR208C Arginine biosynthesis +r_1076 ureidoglycolate hydrolase 2 H+[c] + H2O[c] + ureidoglycolic acid[c] => 2 ammonium[c] + carbon dioxide[c] + glyoxylate[c] YIR032C Purine metabolism +r_1077 uridine kinase (ATP:uridine) ATP[c] + uridine[c] => ADP[c] + H+[c] + UMP[c] YDR020C or YNR012W Pyrimidine metabolism +r_1078 uridine kinase (GTP:uridine) GTP[c] + uridine[c] => GDP[c] + H+[c] + UMP[c] YDR020C or YNR012W Pyrimidine metabolism +r_1079 uridylate kinase (dUMP) ATP[c] + dUMP[c] => ADP[c] + dUDP[c] YKL024C Pyrimidine metabolism +r_1080 uridylate kinase (dUMP) ATP[n] + dUMP[n] => ADP[n] + dUDP[n] YKL024C Pyrimidine metabolism +r_1081 uroporphyrinogen decarboxylase (uroporphyrinogen III) 4 H+[c] + uroporphyrinogen III[c] => 4 carbon dioxide[c] + coproporphyrinogen III[c] YDR047W Porphyrin and chlorophyll metabolism +r_1082 uroporphyrinogen methyltransferase 2 S-adenosyl-L-methionine[c] + uroporphyrinogen III[c] => H+[c] + precorrin-2[c] + 2 S-adenosyl-L-homocysteine[c] YKR069W Porphyrin and chlorophyll metabolism +r_1083 uroporphyrinogen-III synthase preuroporphyrinogen[c] => H2O[c] + uroporphyrinogen III[c] YOR278W Porphyrin and chlorophyll metabolism +r_1084 UTP-glucose-1-phosphate uridylyltransferase D-glucose 1-phosphate[c] + H+[c] + UTP[c] <=> diphosphate[c] + UDP-D-glucose[c] YHL012W or YKL035W Galactose metabolism +r_1085 V-ATPase, Golgi ATP[c] + H+[c] + H2O[c] => ADP[c] + 2 H+[g] + phosphate[c] YBR127C and YDL185W and YEL027W and YEL051W and YGR020C and YHR026W and YHR039C-A and YKL080W and YLR447C and YMR054W and YOR332W and YPL234C and YPR036W Oxidative phosphorylation +r_1086 V-ATPase, vacuole ATP[c] + H+[c] + H2O[c] => ADP[c] + 2 H+[v] + phosphate[c] YBR127C and YDL185W and YEL027W and YEL051W and YGR020C and YHR026W and YHR039C-A and YKL080W and YLR447C and YOR270C and YOR332W and YPL234C and YPR036W Oxidative phosphorylation +r_1087 valine transaminase 2-oxoglutarate[c] + L-valine[c] <=> 3-methyl-2-oxobutanoate[c] + L-glutamate[c] YJR148W Valine, leucine and isoleucine metabolism +r_1088 valine transaminase, mitochondiral 2-oxoglutarate[m] + L-valine[m] <=> 3-methyl-2-oxobutanoate[m] + L-glutamate[m] YHR208W Valine, leucine and isoleucine metabolism +r_1089 valyl-tRNA synthetase ATP[c] + L-valine[c] + tRNA(Val)[c] => AMP[c] + diphosphate[c] + Val-tRNA(Val)[c] YGR094W tRNA metabolism https://www.yeastgenome.org/go/GO:0006399 +r_1090 valyl-tRNA synthetase ATP[m] + L-valine[m] + tRNA(Val)[m] => AMP[m] + diphosphate[m] + Val-tRNA(Val)[m] YGR094W tRNA metabolism https://www.yeastgenome.org/go/GO:0006399 +r_1091 xanthine phosphoribosyltransferase 9H-xanthine[c] + PRPP[c] => diphosphate[c] + xanthosine-5-phosphate[c] YJR133W Purine metabolism +r_1092 xylitol dehydrogenase (D-xyulose-forming) NAD[c] + xylitol[c] => D-xylulose[c] + H+[c] + NADH[c] YLR070C Pentose and glucuronate interconversions +r_1093 xylose reductase D-xylose[c] + H+[c] + NADPH[c] => NADP(+)[c] + xylitol[c] YHR104W Pentose and glucuronate interconversions +r_1094 xylulokinase ATP[c] + D-xylulose[c] => ADP[c] + D-xylulose 5-phosphate[c] + H+[c] YGR194C Pentose and glucuronate interconversions +r_1095 yUMP synthetase ribose-5-phosphate[c] + uracil[c] <=> H2O[c] + pseudouridine 5'-phosphate[c] YFL001W or YGL063W or YNL292W or YPL212C Pyrimidine metabolism +r_1096 (R)-mevalonate transport (R)-mevalonate[e] <=> (R)-mevalonate[c] Transport [c, e] +r_1097 (R,R)-butanediol transport (R,R)-2,3-butanediol[c] <=> (R,R)-2,3-butanediol[e] Transport [c, e] +r_1098 2-methylbutyl transport 2-methylbutyl acetate[c] => 2-methylbutyl acetate[e] Transport [c, e] +r_1099 2-oxoadipate and 2-oxoglutarate transport 2-oxoadipic acid[m] + 2-oxoglutarate[c] <=> 2-oxoadipic acid[c] + 2-oxoglutarate[m] YOR222W or YPL134C Transport [c, m] +r_1100 3-hexaprenyl-4,5-dihydroxybenzoate transport 3-hexaprenyl-4,5-dihydroxybenzoic acid[c] <=> 3-hexaprenyl-4,5-dihydroxybenzoic acid[m] Transport [c, m] +r_1101 4-aminobutyrate transport gamma-aminobutyrate[e] + H+[e] => gamma-aminobutyrate[c] + H+[c] YDL210W or YOR348C Transport [c, e] +r_1102 5-aminolevulinate transport 5-aminolevulinate[e] + H+[e] => 5-aminolevulinate[c] + H+[c] YDL210W Transport [c, e] +r_1103 5-formyltetrahydrofolic acid transport 5-formyltetrahydrofolic acid[e] <=> 5-formyltetrahydrofolic acid[c] Transport [c, e] +r_1104 8-Amino-7-oxononanoate transport 8-amino-7-oxononanoate[e] + H+[e] <=> 8-amino-7-oxononanoate[c] + H+[c] YNR056C Transport [c, e] +r_1106 acetate transport acetate[c] <=> acetate[e] YCR010C Transport [c, e] +r_1107 acetic ester transport ethyl acetate[c] => ethyl acetate[e] Transport [c, e] +r_1108 adenine transport adenine[e] + H+[e] => adenine[c] + H+[c] YER056C or YER060W or YER060W-A or YGL186C Transport [c, e] +r_1109 adenosine transport adenosine[e] + H+[e] => adenosine[c] + H+[c] YAL022C Transport [c, e] +r_1110 ADP/ATP transporter ADP[c] + ATP[m] <=> ADP[m] + ATP[c] YBL030C or YBR085W or YMR056C Transport [c, m] +r_1111 ADP/ATP transporter ADP[p] + ATP[c] + H+[p] => ADP[c] + ATP[p] + H+[c] YPR128C Transport [c, p] +r_1112 AKG transporter, mitochonrial 2-oxoglutarate[c] + citrate[m] <=> 2-oxoglutarate[m] + citrate[c] YMR241W Transport [c, m] +r_1113 allantoate uniport allantoate[e] => allantoate[c] YJR152W Transport [c, e] +r_1114 allantoin uniport allantoin[e] => allantoin[c] YIR028W Transport [c, e] +r_1115 ammonia transport ammonium[e] <=> ammonium[c] YDR384C or YGR121C or YNL142W or YPR138C Transport [c, e] +r_1116 AMP/ATP transporter AMP[p] + ATP[c] + H+[p] => AMP[c] + ATP[p] + H+[c] YPR128C Transport [c, p] +r_1118 aspartate-glutamate transporter L-aspartate[m] + L-glutamate[c] => L-aspartate[c] + L-glutamate[m] YPR021C Transport [c, m] +r_1119 biotin uptake biotin[e] + H+[e] => biotin[c] + H+[c] YGR065C Transport [c, e] +r_1120 carnithine-acetylcarnithine carrier (R)-carnitine[m] + O-acetylcarnitine[c] => (R)-carnitine[c] + O-acetylcarnitine[m] YOR100C Transport [c, m] +r_1121 ceramide-2' (sphinganine:n-C24:0OH) transport ceramide-2' (C24)[er] <=> ceramide-2' (C24)[g] Transport [er, g] +r_1122 ceramide-2' (sphinganine:n-C26:0OH) transport ceramide-2' (C26)[er] <=> ceramide-2' (C26)[g] Transport [er, g] +r_1123 ceramide-3 (Phytosphingosine:n-C24:0OH) transport ceramide-3 (C24)[er] <=> ceramide-3 (C24)[g] Transport [er, g] +r_1124 ceramide-3 (Phytosphingosine:n-C26:0OH) transport ceramide-3 (C26)[er] <=> ceramide-3 (C26)[g] Transport [er, g] +r_1125 choline transport choline[e] + H+[e] => choline[c] + H+[c] YGL077C Transport [c, e] +r_1126 citrate transport (S)-malate[m] + citrate[c] <=> (S)-malate[c] + citrate[m] YBR291C Transport [c, m] +r_1127 citrate transport citrate[c] + phosphoenolpyruvate[m] <=> citrate[m] + phosphoenolpyruvate[c] YBR291C Transport [c, m] +r_1128 citrate transport citrate[c] + isocitrate[m] <=> citrate[m] + isocitrate[c] YBR291C Transport [c, m] +r_1129 coenzyme A transport coenzyme A[c] => coenzyme A[m] YHR002W Transport [c, m] +r_1130 CTP transport CMP[m] + CTP[c] + H+[c] => CMP[c] + CTP[m] + H+[m] YBR192W Transport [c, m] +r_1131 CTP/CMP antiport CMP[m] + CTP[c] + 2 H+[c] => CMP[c] + CTP[m] + 2 H+[m] YBR192W Transport [c, m] +r_1132 cytidine transport cytidine[e] + H+[e] => cytidine[c] + H+[c] YAL022C Transport [c, e] +r_1133 cytosine transport cytosine[e] + H+[e] => cytosine[c] + H+[c] YER056C or YER060W or YER060W-A or YGL186C Transport [c, e] +r_1134 D-fructose transport D-fructose[e] + H+[e] => D-fructose[c] + H+[c] YDL245C or YDR342C or YDR343C or YDR345C or YEL069C or YFL011W or YHR092C or YHR094C or YHR096C or YJL214W or YJL219W or YJR158W or YMR011W or YNR072W or YOL156W Transport [c, e] +r_1135 D-galactose transport D-galactose[e] + H+[e] => D-galactose[c] + H+[c] YDR536W or YFL011W or YJL219W or YLR081W or YNL318C or YOL156W Transport [c, e] +r_1136 D-lactate transport (R)-lactate[e] + H+[e] <=> (R)-lactate[c] + H+[c] YKL217W Transport [c, e] +r_1137 D-lactate transport (R)-lactate[c] + H+[c] => (R)-lactate[m] + H+[m] Transport [c, m] +r_1138 D-lactate/pyruvate antiport (R)-lactate[c] + pyruvate[m] <=> (R)-lactate[m] + pyruvate[c] Transport [c, m] +r_1139 D-mannose transport D-mannose[e] + H+[e] => D-mannose[c] + H+[c] YDL245C or YDR342C or YDR343C or YDR345C or YEL069C or YFL011W or YHR092C or YHR094C or YHR096C or YJL214W or YJL219W or YJR158W or YMR011W or YNR072W or YOL156W Transport [c, e] +r_1146 episterol transport episterol[e] <=> episterol[c] YIL013C or YOR011W Transport [c, e] +r_1147 ergosterol transport ergosterol[e] <=> ergosterol[c] YIL013C or YOR011W Transport [c, e] +r_1148 ergosterol transport ergosterol[ce] <=> ergosterol[c] YIL013C or YOR011W Transport [c, ce] +r_1149 ethanolamine transport ethanolamine[e] <=> ethanolamine[c] YGL077C Transport [c, e] +r_1151 fadH2 transport FADH2[m] => FADH2[c] YIL134W Transport [c, m] +r_1161 fecosterol transport fecosterol[e] <=> fecosterol[c] YIL013C or YOR011W Transport [c, e] +r_1162 fecosterol transport fecosterol[ce] <=> fecosterol[c] YIL013C or YOR011W Transport [c, ce] +r_1164 folic acid transport folate[e] <=> folate[c] Transport [c, e] +r_1165 GDP-mannose antiport GDP-alpha-D-mannose[c] + GMP[g] => GDP-alpha-D-mannose[g] + GMP[c] YGL225W Transport [c, g] +r_1166 glucose transport D-glucose[e] => D-glucose[c] YDL245C or YDL247W or YDR342C or YDR343C or YDR345C or YDR536W or YEL069C or YFL011W or YHR092C or YHR094C or YHR096C or YJL214W or YJL219W or YJR158W or YJR160C or YLR081W or YMR011W or YNR072W or YOL156W or YDR387C Transport [c, e] +r_1167 glutathione transport glutathione[e] => glutathione[c] YJL212C Transport [c, e] +r_1168 glutathione transport glutathione[c] <=> glutathione[v] YDR135C or YLL015W Transport [c, v] +r_1169 glycero-3-phospho-1-inositol transport 1-(sn-glycero-3-phospho)-1D-myo-inositol[e] <=> 1-(sn-glycero-3-phospho)-1D-myo-inositol[c] YCR098C Transport [c, e] +r_1170 glycero-3-phosphocholine transport sn-glycero-3-phosphocholine[e] <=> sn-glycero-3-phosphocholine[c] YCR098C Transport [c, e] +r_1171 glycerol transport glycerol[e] + H+[e] => glycerol[c] + H+[c] YDR536W or YGL084C or YPL189W Transport [c, e] +r_1172 glycerol transport via channel glycerol[c] => glycerol[e] YFL054C or YLL043W Transport [c, e] +r_1173 glycine transport H+[e] + L-glycine[e] <=> H+[c] + L-glycine[c] YCL025C or YKR039W or YOL020W or YOR348C or YPL265W Transport [c, e] +r_1174 glycogen vacuolar 'transport' via autophagy glycogen[c] => glycogen[v] Transport [c, v] +r_1175 GTP/GDP translocase GDP[m] + GTP[c] + H+[c] => GDP[c] + GTP[m] + H+[m] YDL198C Transport [c, m] +r_1176 guanine transport guanine[e] + H+[e] <=> guanine[c] + H+[c] YER056C or YER060W or YER060W-A or YGL186C Transport [c, e] +r_1177 inositol transport H+[e] + myo-inositol[e] => H+[c] + myo-inositol[c] YDR497C or YOL103W Transport [c, e] +r_1178 iron (II) transport iron(2+)[e] => iron(2+)[c] YMR319C or YMR058W Transport [c, e] +r_1179 iron (II) transport iron(2+)[c] => iron(2+)[m] YJL133W or YKR052C Transport [c, m] +r_1180 isoamyl acetate transport isoamyl acetate[c] => isoamyl acetate[e] Transport [c, e] +r_1181 isobutyl acetate transport isobutyl acetate[c] => isobutyl acetate[e] Transport [c, e] +r_1182 isopentenyl diphosphate transport isopentenyl diphosphate[c] <=> isopentenyl diphosphate[m] Transport [c, m] +r_1183 L-alanine transport H+[e] + L-alanine[e] <=> H+[c] + L-alanine[c] YBR068C or YCL025C or YDR046C or YKR039W or YOL020W or YOR348C or YPL265W Transport [c, e] +r_1184 L-arganine transport H+[e] + L-arginine[e] <=> H+[c] + L-arginine[c] YEL063C or YKR039W or YNL270C Transport [c, e] +r_1185 L-arganine transport H+[v] + L-arginine[c] => H+[c] + L-arginine[v] YOL092W or YBR293W Transport [c, v] +r_1186 L-asparagine transport H+[e] + L-asparagine[e] <=> H+[c] + L-asparagine[c] YCL025C or YDR508C or YKR039W or YPL265W Transport [c, e] +r_1187 L-asparagine transport H+[v] + L-asparagine[c] => H+[c] + L-asparagine[v] YJR001W Transport [c, v] +r_1188 L-aspartate transport H+[v] + L-asparagine[v] => H+[c] + L-asparagine[c] YKL146W or YNL101W Transport [c, v] +r_1189 L-aspartate transport H+[v] + L-aspartate[v] => H+[c] + L-aspartate[c] YER119C Transport [c, v] +r_1190 L-aspartate transport H+[e] + L-aspartate[e] <=> H+[c] + L-aspartate[c] YFL055W or YKR039W or YPL265W Transport [c, e] +r_1191 L-carnitine transport (R)-carnitine[e] <=> (R)-carnitine[c] YBR132C Transport [c, e] +r_1192 L-cystine transport H+[e] + L-cysteine[e] <=> H+[c] + L-cysteine[c] YBR068C or YBR069C or YCL025C or YDR046C or YDR508C or YKR039W or YOL020W Transport [c, e] +r_1193 L-cystine transport H+[v] + L-cystine[v] => H+[c] + L-cystine[c] YCR075C Transport [c, v] +r_1194 L-glutamate transport L-glutamate[c] => L-glutamate[m] YPR021C Transport [c, m] +r_1195 L-glutamate transport H+[v] + L-glutamate[v] => H+[c] + L-glutamate[c] YER119C Transport [c, v] +r_1196 L-glutamate transport H+[e] + L-glutamate[e] <=> H+[c] + L-glutamate[c] YCL025C or YFL055W or YKR039W or YPL265W Transport [c, e] +r_1197 L-glutamine transport H+[v] + L-glutamine[c] => H+[c] + L-glutamine[v] YJR001W Transport [c, v] +r_1198 L-glutamine transport H+[v] + L-glutamine[v] => H+[c] + L-glutamine[c] YKL146W or YNL101W Transport [c, v] +r_1199 L-glutamine transport H+[e] + L-glutamine[e] <=> H+[c] + L-glutamine[c] YCL025C or YDR508C or YKR039W or YPL265W Transport [c, e] +r_1200 L-histidine transport, vacuolar H+[v] + L-histidine[c] => H+[c] + L-histidine[v] YOL092W or YBR293W or YCL069W or YMR088C Transport [c, v] +r_1201 L-histidine transport H+[e] + L-histidine[e] <=> H+[c] + L-histidine[c] YBR069C or YGR191W or YKR039W Transport [c, e] +r_1202 L-isoleucine transport L-isoleucine[v] <=> L-isoleucine[c] YCL038C Transport [c, v] +r_1203 L-isoleucine transport H+[v] + L-isoleucine[c] => H+[c] + L-isoleucine[v] YJR001W Transport [c, v] +r_1204 L-isoleucine transport H+[v] + L-isoleucine[v] => H+[c] + L-isoleucine[c] YKL146W or YNL101W Transport [c, v] +r_1205 L-isoleucine transport H+[e] + L-isoleucine[e] <=> H+[c] + L-isoleucine[c] YBR068C or YBR069C or YCL025C or YDR046C or YKR039W Transport [c, e] +r_1206 L-lactate transport (S)-lactate[c] <=> (S)-lactate[m] YKL217W Transport [c, m] +r_1207 L-lactate transport (S)-lactate[e] + H+[e] => (S)-lactate[c] + H+[c] YKL217W Transport [c, e] +r_1208 L-leucine transport, vacuoluar L-leucine[v] <=> L-leucine[c] YCL038C Transport [c, v] +r_1209 L-leucine transport, vacuoluar H+[v] + L-leucine[c] => H+[c] + L-leucine[v] YJR001W Transport [c, v] +r_1210 L-leucine transport, vacuoluar H+[v] + L-leucine[v] => H+[c] + L-leucine[c] YKL146W or YNL101W Transport [c, v] +r_1211 L-leucine transport H+[e] + L-leucine[e] <=> H+[c] + L-leucine[c] YBR068C or YBR069C or YCL025C or YDR046C or YDR508C or YKR039W Transport [c, e] +r_1212 L-lysine transport H+[v] + L-lysine[c] => H+[c] + L-lysine[v] YOL092W or YBR293W or YCL069W or YMR088C Transport [c, v] +r_1213 L-lysine transport H+[e] + L-lysine[e] <=> H+[c] + L-lysine[c] YKR039W or YNL268W Transport [c, e] +r_1214 L-methionine transport H+[e] + L-methionine[e] <=> H+[c] + L-methionine[c] YBR068C or YCL025C or YDR046C or YDR508C or YGR055W or YHL036W or YKR039W Transport [c, e] +r_1215 L-phenylalanine transport H+[e] + L-phenylalanine[e] <=> H+[c] + L-phenylalanine[c] YBR068C or YCL025C or YDR046C or YKR039W or YOL020W Transport [c, e] +r_1216 L-proline transport H+[e] + L-proline[e] <=> H+[c] + L-proline[c] YKR039W or YOR348C Transport [c, e] +r_1217 L-serine transport H+[e] + L-serine[e] <=> H+[c] + L-serine[c] YCL025C or YDR508C or YFL055W or YKR039W or YPL265W or YDR105C Transport [c, e] +r_1218 L-threonine transport H+[e] + L-threonine[e] <=> H+[c] + L-threonine[c] YBR069C or YCL025C or YDR046C or YDR508C or YKR039W Transport [c, e] +r_1219 L-tryptophan transport H+[e] + L-tryptophan[e] <=> H+[c] + L-tryptophan[c] YBR068C or YBR069C or YDR046C or YKR039W or YOL020W Transport [c, e] +r_1220 L-tyrosine transport L-tyrosine[v] <=> L-tyrosine[c] YCL038C Transport [c, v] +r_1221 L-tyrosine transport H+[v] + L-tyrosine[c] => H+[c] + L-tyrosine[v] YBR293W or YJR001W Transport [c, v] +r_1222 L-tyrosine transport H+[v] + L-tyrosine[v] => H+[c] + L-tyrosine[c] YKL146W or YNL101W Transport [c, v] +r_1223 L-tyrosine transport H+[e] + L-tyrosine[e] <=> H+[c] + L-tyrosine[c] YBR068C or YBR069C or YCL025C or YDR046C or YKR039W or YOL020W Transport [c, e] +r_1224 L-valine transport H+[e] + L-valine[e] <=> H+[c] + L-valine[c] YBR068C or YBR069C or YCL025C or YDR046C or YKR039W Transport [c, e] +r_1225 lanosterol transport lanosterol[e] <=> lanosterol[c] YIL013C or YOR011W Transport [c, e] +r_1226 malate transport (S)-malate[c] + phosphate[m] => (S)-malate[m] + phosphate[c] YLR348C Transport [c, m] +r_1227 maltose transport H+[e] + maltose[e] => H+[c] + maltose[c] YBR298C or YDL247W or YGR289C or YJR160C Transport [c, e] +r_1228 N,N'-diformyldityrosine transport N,N'-diformyldityrosine[c] => N,N'-diformyldityrosine[e] YBR180W Transport [c, e] +r_1229 NAD transport NAD[c] => NAD[m] YEL006W or YIL006W Transport [c, m] +r_1230 NAD transport dAMP[m] + NAD[c] => dAMP[c] + NAD[m] YIL006W Transport [c, m] +r_1231 NAD transport AMP[m] + NAD[c] => AMP[c] + NAD[m] YIL006W Transport [c, m] +r_1232 NAD transport dGMP[m] + NAD[c] => dGMP[c] + NAD[m] YIL006W Transport [c, m] +r_1235 nicotinate transport nicotinate[e] <=> nicotinate[c] YGR260W Transport [c, e] +r_1236 octadecanoate (n-C18:0) transport stearate[c] <=> stearate[p] YKL188C and YPL147W Transport [c, p] +r_1237 ornithine transport H+[c] + ornithine[m] => H+[m] + ornithine[c] YOR130C Transport [c, m] +r_1238 orntithine transport H+[e] + ornithine[e] <=> H+[c] + ornithine[c] YEL063C or YKR039W Transport [c, e] +r_1239 oxaloacetate transport H+[c] + oxaloacetate[c] => H+[m] + oxaloacetate[m] YKL120W Transport [c, m] +r_1241 pantothenate transport (R)-pantothenate[e] + H+[e] <=> (R)-pantothenate[c] + H+[c] YCR028C Transport [c, e] +r_1242 pentaprenyl diphosphate transport pentaprenyl diphosphate[c] <=> pentaprenyl diphosphate[m] Transport [c, m] +r_1243 phenethyl acetate transport phenethyl acetate[c] => phenethyl acetate[e] Transport [c, e] +r_1244 phosphate transport H+[e] + phosphate[e] <=> H+[c] + phosphate[c] YBR296C or YCR037C or YJL198W or YML123C or YNR013C Transport [c, e] +r_1245 phosphate transport H+[c] + phosphate[c] => H+[m] + phosphate[m] YER053C or YJR077C Transport [c, m] +r_1249 potassium transport H+[e] + potassium[e] <=> H+[c] + potassium[c] YDR456W or YJL129C Transport [c, e] +r_1250 putrescine excretion putrescine[c] => putrescine[e] YKL174C Transport [c, e] +r_1251 putrescine transport H+[c] + putrescine[e] <=> H+[e] + putrescine[c] YLL028W or YOR273C Transport [c, e] +r_1252 putrescine transport H+[v] + putrescine[c] <=> H+[c] + putrescine[v] YLL028W or YOR273C Transport [c, v] +r_1253 pyridoxine symport H+[e] + pyridoxine[e] <=> H+[c] + pyridoxine[c] YGL186C Transport [c, e] +r_1254 pyruvate transport H+[e] + pyruvate[e] <=> H+[c] + pyruvate[c] YKL217W Transport [c, e] +r_1255 S-adenosyl-L-methionine transport H+[e] + S-adenosyl-L-methionine[e] => H+[c] + S-adenosyl-L-methionine[c] YPL274W Transport [c, e] +r_1256 S-adenosyl-L-methionine transport S-adenosyl-L-methionine[c] <=> S-adenosyl-L-methionine[m] YNL003C Transport [c, m] +r_1257 S-methylmethionine permease H+[e] + S-methyl-L-methionine[e] => H+[c] + S-methyl-L-methionine[c] YLL061W Transport [c, e] +r_1258 sodium proton antiporter H+[e] + sodium[c] <=> H+[c] + sodium[e] YDR456W or YLR138W Transport [c, e] +r_1259 spermidine excretion spermidine[c] => spermidine[e] YKL174C Transport [c, e] +r_1260 spermidine transport H+[c] + spermidine[e] <=> H+[e] + spermidine[c] YBR132C or YHL016C or YKR039W or YLL028W or YOR273C or YPL274W Transport [c, e] +r_1261 spermidine transport H+[v] + spermidine[c] <=> H+[c] + spermidine[v] YLL028W or YOR273C Transport [c, v] +r_1262 spermine transport H+[c] + spermine[e] <=> H+[e] + spermine[c] YGR138C or YLL028W or YOR273C or YPR156C Transport [c, e] +r_1263 spermine transport H+[v] + spermine[c] <=> H+[c] + spermine[v] YGR138C or YLL028W or YOR273C or YPR156C Transport [c, v] +r_1264 succinate transport phosphate[m] + succinate[c] => phosphate[c] + succinate[m] YLR348C Transport [c, m] +r_1265 succinate-fumarate transport fumarate[m] + succinate[c] => fumarate[c] + succinate[m] YJR095W Transport [c, m] +r_1266 sulfate uniport sulphate[e] => sulphate[c] YBR294W or YLR092W Transport [c, e] +r_1267 sulfite transport sulphite[c] => sulphite[e] YPL092W Transport [c, e] +r_1268 taurine transport taurine[c] <=> taurine[e] Transport [c, e] +r_1269 thiamine diphosphate transport TDP[c] => TDP[m] YGR096W Transport [c, m] +r_1270 thiamine transport H+[e] + thiamine[e] => H+[c] + thiamine[c] YLR237W or YOR071C or YOR192C Transport [c, e] +r_1271 UDPgalactose transport UDP-D-galactose[c] => UDP-D-galactose[g] YPL244C Transport [c, g] +r_1272 uracil transport H+[e] + uracil[e] => H+[c] + uracil[c] YBR021W Transport [c, e] +r_1273 urea transport 2 H+[e] + urea[e] <=> 2 H+[c] + urea[c] YHL016C Transport [c, e] +r_1274 uridine transport H+[e] + uridine[e] => H+[c] + uridine[c] YBL042C Transport [c, e] +r_1275 UTP transport FMN[m] + H+[c] + UMP[m] + UTP[c] => FMN[c] + H+[m] + UMP[c] + UTP[m] YBR192W Transport [c, m] +r_1276 UTP/UMP antiport 2 H+[c] + UMP[m] + UTP[c] => 2 H+[m] + UMP[c] + UTP[m] YBR192W Transport [c, m] +r_1277 water diffusion H2O[e] <=> H2O[c] YLL052C or YPR192W Transport [c, e] +r_1278 zymosterol transport zymosterol[e] <=> zymosterol[ce] YIL013C or YOR011W Transport [e, ce] +r_1449 inositol-P-ceramide B' (C24) [Golgi] SLIME rxn inositol-P-ceramide B' (C24)[g] => 0.91026 inositol-P-ceramide backbone[g] + 0.28448 C18:0 chain[c] + 0.36864 C24:0 chain[c] SLIME reaction +r_1450 inositol-P-ceramide B' (C26) [Golgi] SLIME rxn inositol-P-ceramide B' (C26)[g] => 0.93832 inositol-P-ceramide backbone[g] + 0.28448 C18:0 chain[c] + 0.3967 C26:0 chain[c] SLIME reaction +r_1451 inositol-P-ceramide C (C24) [Golgi] SLIME rxn inositol-P-ceramide C (C24)[g] => 0.92626 inositol-P-ceramide backbone[g] + 0.28448 C18:0 chain[c] + 0.36864 C24:0 chain[c] SLIME reaction +r_1452 inositol-P-ceramide C (C26) [Golgi] SLIME rxn inositol-P-ceramide C (C26)[g] => 0.95432 inositol-P-ceramide backbone[g] + 0.28448 C18:0 chain[c] + 0.3967 C26:0 chain[c] SLIME reaction +r_1453 inositol-P-ceramide A (C24) [Golgi] SLIME rxn inositol-P-ceramide A (C24)[g] => 0.89426 inositol-P-ceramide backbone[g] + 0.28448 C18:0 chain[c] + 0.36864 C24:0 chain[c] SLIME reaction +r_1454 inositol-P-ceramide A (C26) [Golgi] SLIME rxn inositol-P-ceramide A (C26)[g] => 0.92232 inositol-P-ceramide backbone[g] + 0.28448 C18:0 chain[c] + 0.3967 C26:0 chain[c] SLIME reaction +r_1455 inositol-P-ceramide B (C24) [Golgi] SLIME rxn inositol-P-ceramide B (C24)[g] => 0.91026 inositol-P-ceramide backbone[g] + 0.28448 C18:0 chain[c] + 0.36864 C24:0 chain[c] SLIME reaction +r_1456 inositol-P-ceramide B (C26) [Golgi] SLIME rxn inositol-P-ceramide B (C26)[g] => 0.93832 inositol-P-ceramide backbone[g] + 0.28448 C18:0 chain[c] + 0.3967 C26:0 chain[c] SLIME reaction +r_1457 inositol-P-ceramide D (C24) [Golgi] SLIME rxn inositol-P-ceramide D (C24)[g] => 0.94226 inositol-P-ceramide backbone[g] + 0.28448 C18:0 chain[c] + 0.36864 C24:0 chain[c] SLIME reaction +r_1458 inositol-P-ceramide D (C26) [Golgi] SLIME rxn inositol-P-ceramide D (C26)[g] => 0.97032 inositol-P-ceramide backbone[g] + 0.28448 C18:0 chain[c] + 0.3967 C26:0 chain[c] SLIME reaction +r_1479 inositol phosphomannosylinositol phosphoceramide A (C24) [Golgi] SLIME rxn inositol phosphomannosylinositol phosphoceramide A (C24)[g] => 1.2985 inositol phosphomannosylinositol phosphoceramide backbone[g] + 0.28448 C18:0 chain[c] + 0.36864 C24:0 chain[c] SLIME reaction +r_1480 inositol phosphomannosylinositol phosphoceramide A (C26) [Golgi] SLIME rxn inositol phosphomannosylinositol phosphoceramide A (C26)[g] => 1.3266 inositol phosphomannosylinositol phosphoceramide backbone[g] + 0.28448 C18:0 chain[c] + 0.3967 C26:0 chain[c] SLIME reaction +r_1481 inositol phosphomannosylinositol phosphoceramide B' (C24) [Golgi] SLIME rxn inositol phosphomannosylinositol phosphoceramide B' (C24)[g] => 1.3145 inositol phosphomannosylinositol phosphoceramide backbone[g] + 0.28448 C18:0 chain[c] + 0.36864 C24:0 chain[c] SLIME reaction +r_1482 inositol phosphomannosylinositol phosphoceramide B' (C26) [Golgi] SLIME rxn inositol phosphomannosylinositol phosphoceramide B' (C26)[g] => 1.3426 inositol phosphomannosylinositol phosphoceramide backbone[g] + 0.28448 C18:0 chain[c] + 0.3967 C26:0 chain[c] SLIME reaction +r_1483 inositol phosphomannosylinositol phosphoceramide B (C24) [Golgi] SLIME rxn inositol phosphomannosylinositol phosphoceramide B (C24)[g] => 1.3145 inositol phosphomannosylinositol phosphoceramide backbone[g] + 0.28448 C18:0 chain[c] + 0.36864 C24:0 chain[c] SLIME reaction +r_1484 inositol phosphomannosylinositol phosphoceramide B (C26) [Golgi] SLIME rxn inositol phosphomannosylinositol phosphoceramide B (C26)[g] => 1.3426 inositol phosphomannosylinositol phosphoceramide backbone[g] + 0.28448 C18:0 chain[c] + 0.3967 C26:0 chain[c] SLIME reaction +r_1485 inositol phosphomannosylinositol phosphoceramide C (C24) [Golgi] SLIME rxn inositol phosphomannosylinositol phosphoceramide C (C24)[g] => 1.3305 inositol phosphomannosylinositol phosphoceramide backbone[g] + 0.28448 C18:0 chain[c] + 0.36864 C24:0 chain[c] SLIME reaction +r_1486 inositol phosphomannosylinositol phosphoceramide C (C26) [Golgi] SLIME rxn inositol phosphomannosylinositol phosphoceramide C (C26)[g] => 1.3586 inositol phosphomannosylinositol phosphoceramide backbone[g] + 0.28448 C18:0 chain[c] + 0.3967 C26:0 chain[c] SLIME reaction +r_1487 inositol phosphomannosylinositol phosphoceramide D (C24) [Golgi] SLIME rxn inositol phosphomannosylinositol phosphoceramide D (C24)[g] => 1.3465 inositol phosphomannosylinositol phosphoceramide backbone[g] + 0.28448 C18:0 chain[c] + 0.36864 C24:0 chain[c] SLIME reaction +r_1488 inositol phosphomannosylinositol phosphoceramide D (C26) [Golgi] SLIME rxn inositol phosphomannosylinositol phosphoceramide D (C26)[g] => 1.3746 inositol phosphomannosylinositol phosphoceramide backbone[g] + 0.28448 C18:0 chain[c] + 0.3967 C26:0 chain[c] SLIME reaction +r_1509 mannosylinositol phosphorylceramide B' (C24) [Golgi] SLIME rxn mannosylinositol phosphorylceramide B' (C24)[g] => 1.0724 mannosylinositol phosphorylceramide backbone[g] + 0.28448 C18:0 chain[c] + 0.36864 C24:0 chain[c] SLIME reaction +r_1510 mannosylinositol phosphorylceramide B' (C26) [Golgi] SLIME rxn mannosylinositol phosphorylceramide B' (C26)[g] => 1.1005 mannosylinositol phosphorylceramide backbone[g] + 0.28448 C18:0 chain[c] + 0.3967 C26:0 chain[c] SLIME reaction +r_1511 mannosylinositol phosphorylceramide C (C24) [Golgi] SLIME rxn mannosylinositol phosphorylceramide C (C24)[g] => 1.0884 mannosylinositol phosphorylceramide backbone[g] + 0.28448 C18:0 chain[c] + 0.36864 C24:0 chain[c] SLIME reaction +r_1512 mannosylinositol phosphorylceramide C (C26) [Golgi] SLIME rxn mannosylinositol phosphorylceramide C (C26)[g] => 1.1165 mannosylinositol phosphorylceramide backbone[g] + 0.28448 C18:0 chain[c] + 0.3967 C26:0 chain[c] SLIME reaction +r_1513 mannosylinositol phosphorylceramide A (C24) [Golgi] SLIME rxn mannosylinositol phosphorylceramide A (C24)[g] => 1.0564 mannosylinositol phosphorylceramide backbone[g] + 0.28448 C18:0 chain[c] + 0.36864 C24:0 chain[c] SLIME reaction +r_1514 mannosylinositol phosphorylceramide A (C26) [Golgi] SLIME rxn mannosylinositol phosphorylceramide A (C26)[g] => 1.0845 mannosylinositol phosphorylceramide backbone[g] + 0.28448 C18:0 chain[c] + 0.3967 C26:0 chain[c] SLIME reaction +r_1515 mannosylinositol phosphorylceramide B (C24) [Golgi] SLIME rxn mannosylinositol phosphorylceramide B (C24)[g] => 1.0724 mannosylinositol phosphorylceramide backbone[g] + 0.28448 C18:0 chain[c] + 0.36864 C24:0 chain[c] SLIME reaction +r_1516 mannosylinositol phosphorylceramide B (C26) [Golgi] SLIME rxn mannosylinositol phosphorylceramide B (C26)[g] => 1.1005 mannosylinositol phosphorylceramide backbone[g] + 0.28448 C18:0 chain[c] + 0.3967 C26:0 chain[c] SLIME reaction +r_1517 mannosylinositol phosphorylceramide D (C24) [Golgi] SLIME rxn mannosylinositol phosphorylceramide D (C24)[g] => 1.1044 mannosylinositol phosphorylceramide backbone[g] + 0.28448 C18:0 chain[c] + 0.36864 C24:0 chain[c] SLIME reaction +r_1518 mannosylinositol phosphorylceramide D (C26) [Golgi] SLIME rxn mannosylinositol phosphorylceramide D (C26)[g] => 1.1325 mannosylinositol phosphorylceramide backbone[g] + 0.28448 C18:0 chain[c] + 0.3967 C26:0 chain[c] SLIME reaction +r_1542 (1->3)-beta-D-glucan exchange (1->3)-beta-D-glucan[e] => Exchange reaction +r_1543 (1->3)-beta-D-glucan transport (1->3)-beta-D-glucan[ce] <=> (1->3)-beta-D-glucan[c] Transport [c, ce] +r_1545 (R)-carnitine exchange (R)-carnitine[e] => Exchange reaction +r_1546 (R)-lactate exchange (R)-lactate[e] => Exchange reaction +r_1547 (R)-mevalonate exchange (R)-mevalonate[e] => Exchange reaction +r_1548 (R)-pantothenate exchange (R)-pantothenate[e] => Exchange reaction +r_1549 (R,R)-2,3-butanediol exchange (R,R)-2,3-butanediol[e] => Exchange reaction +r_1550 (S)-3-methyl-2-oxopentanoate exchange (S)-3-methyl-2-oxopentanoate[e] => Exchange reaction +r_1551 (S)-lactate exchange (S)-lactate[e] => Exchange reaction +r_1552 (S)-malate exchange (S)-malate[e] => Exchange reaction +r_1553 1-(sn-glycero-3-phospho)-1D-myo-inositol exchange 1-(sn-glycero-3-phospho)-1D-myo-inositol[e] => Exchange reaction +r_1554 1-acylglycerophosphocholine exchange 1-acylglycerophosphocholine[e] => Exchange reaction +r_1560 1D-myo-inositol 1,3,4,5,6-pentakisphosphate diffusion myo-inositol 1,3,4,5,6-pentakisphosphate[c] <=> myo-inositol 1,3,4,5,6-pentakisphosphate[n] Transport [c, n] +r_1562 1D-myo-inositol 1-phosphate transport 1D-myo-inositol 1-phosphate[er] <=> 1D-myo-inositol 1-phosphate[c] Transport [c, er] +r_1563 2'-deoxyadenosine exchange 2'-deoxyadenosine[e] => Exchange reaction +r_1564 2'-deoxyguanosine exchange 2'-deoxyguanosine[e] => Exchange reaction +r_1565 2'-deoxyinosine exchange 2'-deoxyinosine[e] => Exchange reaction +r_1566 2'-deoxyuridine exchange 2'-deoxyuridine[e] => Exchange reaction +r_1567 2-dehydro-3-deoxy-D-arabino-heptonate7-phohsphate transport 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonic acid[c] <=> 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonic acid[m] Transport [c, m] +r_1568 2-dehydropantoate transport 2-dehydropantoate[c] <=> 2-dehydropantoate[m] Transport [c, m] +r_1572 2-isopropylmalate exchange 2-isopropylmalate[e] => Exchange reaction +r_1573 2-isopropylmalate transport 2-isopropylmalate[c] <=> 2-isopropylmalate[e] Transport [c, e] +r_1574 2-isopropylmalate transport 2-isopropylmalate[c] <=> 2-isopropylmalate[m] YKL120W Transport [c, m] +r_1575 2-methyl-1-butanol transport 2-methylbutanol[c] <=> 2-methylbutanol[e] Transport [c, e] +r_1576 2-methyl-1-butanol transport 2-methylbutanol[c] <=> 2-methylbutanol[m] Transport [c, m] +r_1577 2-methylbutanal exchange 2-methylbutanal[e] => Exchange reaction +r_1578 2-methylbutanal transport 2-methylbutanal[c] <=> 2-methylbutanal[e] Transport [c, e] +r_1579 2-methylbutanal transport 2-methylbutanal[c] <=> 2-methylbutanal[m] Transport [c, m] +r_1580 2-methylbutanol exchange 2-methylbutanol[e] => Exchange reaction +r_1581 2-methylbutyl acetate exchange 2-methylbutyl acetate[e] => Exchange reaction +r_1582 2-methylpropanal transport isobutyraldehyde[c] <=> isobutyraldehyde[e] Transport [c, e] +r_1583 2-methylpropanal transport isobutyraldehyde[c] <=> isobutyraldehyde[m] Transport [c, m] +r_1585 2-oxobutanoate transporter 2-oxobutanoate[c] <=> 2-oxobutanoate[m] Transport [c, m] +r_1586 2-oxoglutarate exchange 2-oxoglutarate[e] => Exchange reaction +r_1587 2-oxoglutarate transport 2-oxoglutarate[c] <=> 2-oxoglutarate[n] Transport [c, n] +r_1588 2-oxoglutarate transport 2-oxoglutarate[e] <=> 2-oxoglutarate[c] Transport [c, e] +r_1589 2-phenylethanol exchange 2-phenylethanol[e] => Exchange reaction +r_1590 2-phenylethanol transport 2-phenylethanol[e] <=> 2-phenylethanol[c] Transport [c, e] +r_1591 2-phenylethanol transport 2-phenylethanol[m] <=> 2-phenylethanol[c] Transport [c, m] +r_1595 3-carboxy-4-methyl-2-oxopentanoate transport (2S)-2-isopropyl-3-oxosuccinate[c] <=> (2S)-2-isopropyl-3-oxosuccinate[m] Transport [c, m] +r_1596 3-methyl-2-oxopentanoate transport (S)-3-methyl-2-oxopentanoate[c] <=> (S)-3-methyl-2-oxopentanoate[m] Transport [c, m] +r_1597 3-methyl-oxopentanoate trasport (S)-3-methyl-2-oxopentanoate[e] <=> (S)-3-methyl-2-oxopentanoate[c] Transport [c, e] +r_1598 3-methylbutanal exchange 3-methylbutanal[e] => Exchange reaction +r_1599 3-methylbutanal transport 3-methylbutanal[c] <=> 3-methylbutanal[e] Transport [c, e] +r_1600 3-methylbutanal transport 3-methylbutanal[c] <=> 3-methylbutanal[m] Transport [c, m] +r_1601 3-octaprenyl-4-hydroxybenzoate transport 3-hexaprenyl-4-hydroxybenzoic acid[c] <=> 3-hexaprenyl-4-hydroxybenzoic acid[m] Transport [c, m] +r_1603 4-amino-5-hydroxymethyl-2-methylpyrimidine synthetase 5'-phosphoribosyl-5-aminoimidazole[c] => 4-amino-5-hydroxymethyl-2-methylpyrimidine[c] + glycolaldehyde[c] + H+[c] + phosphate[c] YFL058W Thiamine metabolism +r_1604 4-aminobenzoate exchange 4-aminobenzoate[e] => Exchange reaction +r_1605 4-aminobenzoate transport 4-aminobenzoate[c] <=> 4-aminobenzoate[e] Transport [c, e] +r_1606 4-aminobenzoate transport 4-aminobenzoate[c] <=> 4-aminobenzoate[m] Transport [c, m] +r_1607 4-aminobutanal transport 4-aminobutanal[c] <=> 4-aminobutanal[m] Transport [c, m] +r_1608 4-aminobutyrate transport gamma-aminobutyrate[c] <=> gamma-aminobutyrate[m] Transport [c, m] +r_1609 4-hydroxy-2-oxoglutarate transport 4-hydroxy-2-oxoglutarate[c] <=> 4-hydroxy-2-oxoglutarate[m] Transport [c, m] +r_1610 4-hydroxy-2-oxoglutarate transport 4-hydroxy-2-oxoglutarate[c] <=> 4-hydroxy-2-oxoglutarate[p] Transport [c, p] +r_1611 4-hydroxybenzoate transport 4-hydroxybenzoate[c] <=> 4-hydroxybenzoate[m] Transport [c, m] +r_1613 5'-nucleotidase (AMP) AMP[c] + H2O[c] => adenosine[c] + phosphate[c] Purine metabolism +r_1614 5'-nucleotidase (dAMP) dAMP[c] + H2O[c] => 2'-deoxyadenosine[c] + phosphate[c] Purine metabolism +r_1615 5'-nucleotidase (dCMP) dCMP[c] + H2O[c] => deoxycytidine[c] + phosphate[c] Pyrimidine metabolism +r_1616 5'-nucleotidase (dGMP) dGMP[c] + H2O[c] => 2'-deoxyguanosine[c] + phosphate[c] Purine metabolism +r_1617 5'-nucleotidase (dTMP) dTMP[c] + H2O[c] => phosphate[c] + thymidine[c] Pyrimidine metabolism +r_1618 5'-nucleotidase (dUMP) dUMP[c] + H2O[c] => 2'-deoxyuridine[c] + phosphate[c] Pyrimidine metabolism +r_1619 5'-nucleotidase (GMP) GMP[c] + H2O[c] => guanosine[c] + phosphate[c] YER037W Purine metabolism +r_1620 5'-nucleotidase (XMP) H2O[c] + xanthosine-5-phosphate[c] => phosphate[c] + xanthosine[c] Purine metabolism +r_1621 5-aminolevulinate exchange 5-aminolevulinate[e] => Exchange reaction +r_1622 5-aminolevulinate transport 5-aminolevulinate[c] <=> 5-aminolevulinate[m] Transport [c, m] +r_1623 5-formethyltetrahydrofolate cyclo-ligase 5-formyltetrahydrofolic acid[m] + ATP[m] => 5,10-methenyl-THF[m] + ADP[m] + phosphate[m] YER183C One carbon pool by folate +r_1624 5-formyltetrahydrofolate:10-formyltetrahydrofolate isomerase 5-formyltetrahydrofolic acid[c] + ATP[c] + H2O[c] => 10-formyl-THF[c] + ADP[c] + H+[c] + phosphate[c] YER183C One carbon pool by folate +r_1625 5-formyltetrahydrofolic acid exchange 5-formyltetrahydrofolic acid[e] => Exchange reaction +r_1627 7,8-diaminononanoate exchange 7,8-diaminononanoate[e] => Exchange reaction +r_1628 7,8-diaminononanoate transport 7,8-diaminononanoate[e] <=> 7,8-diaminononanoate[c] Transport [c, e] +r_1629 8-amino-7-oxononanoate exchange 8-amino-7-oxononanoate[e] => Exchange reaction +r_1630 9H-xanthine exchange 9H-xanthine[e] => Exchange reaction +r_1631 acetaldehyde exchange acetaldehyde[e] => Exchange reaction +r_1632 acetaldehyde transport acetaldehyde[m] <=> acetaldehyde[c] Transport [c, m] +r_1633 acetaldehyde transport acetaldehyde[e] <=> acetaldehyde[c] Transport [c, e] +r_1634 acetate exchange acetate[e] => Exchange reaction +r_1635 acetate transport acetate[c] <=> acetate[n] Transport [c, n] +r_1637 acetyl-CoA transport acetyl-CoA[c] <=> acetyl-CoA[n] Transport [c, n] +r_1638 acetylcarnitine transport O-acetylcarnitine[p] => O-acetylcarnitine[c] Transport [c, p] +r_1639 adenine exchange adenine[e] => Exchange reaction +r_1640 adenine transport adenine[c] <=> adenine[m] Transport [c, m] +r_1641 adenosine 3',5'-bismonophosphate exchange adenosine 3',5'-bismonophosphate[e] => Exchange reaction +r_1642 adenosine 3',5'-bisphosphate transport adenosine 3',5'-bismonophosphate[c] <=> adenosine 3',5'-bismonophosphate[m] YPR011C Transport [c, m] +r_1643 adenosine exchange adenosine[e] => Exchange reaction +r_1644 ADP transport ADP[c] <=> ADP[n] Transport [c, n] +r_1645 ADP transport ADP[c] <=> ADP[er] Transport [c, er] +r_1647 AKG transporter, peroxisome 2-oxoglutarate[c] <=> 2-oxoglutarate[p] Transport [c, p] +r_1648 allantoate exchange allantoate[e] => Exchange reaction +r_1649 allantoin exchange allantoin[e] => Exchange reaction +r_1650 trehalose exchange trehalose[e] => Exchange reaction +r_1651 alpha-D-glucosamine 6-phosphate exchange alpha-D-glucosamine 6-phosphate[e] => Exchange reaction +r_1652 alpha-ketoglutarate/malate transporter (S)-malate[e] + 2-oxoglutarate[c] <=> (S)-malate[c] + 2-oxoglutarate[e] Transport [c, e] +r_1654 ammonium exchange ammonium[e] <=> Exchange reaction +r_1656 AMP transport AMP[n] <=> AMP[c] Transport [c, n] +r_1657 arginine transport H+[c] + L-arginine[c] => H+[m] + L-arginine[m] YBR147W Transport [c, m] +r_1658 asparagine transport L-asparagine[c] => L-asparagine[m] YDR508C Transport [c, m] +r_1659 aspartate-glutamate transporter L-aspartate[c] + L-glutamate[p] <=> L-aspartate[p] + L-glutamate[c] Transport [c, p] +r_1660 ATP diffusion ATP[c] <=> ATP[n] Transport [c, n] +r_1661 ATP transport ATP[c] <=> ATP[er] Transport [c, er] +r_1663 bicarbonate exchange bicarbonate[e] => Exchange reaction +r_1664 bicarbonate formation carbon dioxide[m] + H2O[m] <=> bicarbonate[m] + H+[m] Nitrogen metabolism +r_1665 bicarbonate formation carbon dioxide[n] + H2O[n] <=> bicarbonate[n] + H+[n] Nitrogen metabolism +r_1667 bicarbonate formation carbon dioxide[c] + H2O[c] <=> bicarbonate[c] + H+[c] YNL036W Nitrogen metabolism +r_1668 bicarbonate formation carbon dioxide[e] + H2O[e] <=> bicarbonate[e] + H+[e] Nitrogen metabolism +r_1669 bicarbonate transport bicarbonate[c] <=> bicarbonate[n] Transport [c, n] +r_1671 biotin exchange biotin[e] => Exchange reaction +r_1672 carbon dioxide exchange carbon dioxide[e] => Exchange reaction +r_1673 carnitine transport (R)-carnitine[c] => (R)-carnitine[p] Transport [c, p] +r_1674 carnitine-acetylcarnitine carrier (R)-carnitine[c] + O-acetylcarnitine[p] => (R)-carnitine[p] + O-acetylcarnitine[c] Transport [c, p] +r_1675 CDP transport CDP[c] <=> CDP[n] Transport [c, n] +r_1676 ceramide transport ceramide-1 (C24)[g] <=> ceramide-1 (C24)[er] Transport [er, g] +r_1677 ceramide transport ceramide-2 (C24)[g] <=> ceramide-2 (C24)[er] Transport [er, g] +r_1678 ceramide transport ceramide-4 (C24)[g] <=> ceramide-4 (C24)[er] Transport [er, g] +r_1679 ceramide transport ceramide-1 (C26)[g] <=> ceramide-1 (C26)[er] Transport [er, g] +r_1680 ceramide transport ceramide-2 (C26)[g] <=> ceramide-2 (C26)[er] Transport [er, g] +r_1681 ceramide transport ceramide-4 (C26)[g] <=> ceramide-4 (C26)[er] Transport [er, g] +r_1682 cholestenol delta-isomerase, lumped reaction oxygen[c] + S-adenosyl-L-methionine[c] + zymosterol[c] => ergosta-5,7,22,24(28)-tetraen-3beta-ol[c] + H+[c] + 2 H2O[c] + S-adenosyl-L-homocysteine[c] Steroid biosynthesis +r_1683 choline exchange choline[e] => Exchange reaction +r_1684 choline transport choline[ce] <=> choline[c] YGL077C or YOR161C Transport [c, ce] +r_1685 chorismate pyruvate lyase chorismate[c] => 4-hydroxybenzoate[c] + pyruvate[c] Ubiquinone and other terpenoid-quinone biosynthesis +r_1686 citrate transport citrate[e] <=> citrate[c] Transport [c, e] +r_1687 citrate exchange citrate[e] => Exchange reaction +r_1688 citrate/isocitrate antiport citrate[c] + isocitrate[p] <=> citrate[p] + isocitrate[c] Transport [c, p] +r_1689 citrate/malate antiport (S)-malate[c] + citrate[p] <=> (S)-malate[p] + citrate[c] Transport [c, p] +r_1690 CMP nucleosidase CMP[c] + H2O[c] => cytosine[c] + ribose-5-phosphate[c] Pyrimidine metabolism +r_1691 CO2 transport carbon dioxide[c] <=> carbon dioxide[er] Transport [c, er] +r_1694 CO2 transport carbon dioxide[n] <=> carbon dioxide[c] Transport [c, n] +r_1695 CO2 transport carbon dioxide[c] <=> carbon dioxide[p] Transport [c, p] +r_1696 CO2 transport carbon dioxide[c] <=> carbon dioxide[m] Transport [c, m] +r_1697 CO2 transport carbon dioxide[c] <=> carbon dioxide[e] Transport [c, e] +r_1698 coenzyme A transport coenzyme A[c] <=> coenzyme A[er] Transport [c, er] +r_1699 coenzyme A transport coenzyme A[c] <=> coenzyme A[n] Transport [c, n] +r_1700 coenzyme A transport coenzyme A[p] <=> coenzyme A[c] Transport [c, p] +r_1702 cytidine exchange cytidine[e] => Exchange reaction +r_1703 cytidylate kinase (CMP) ATP[c] + CMP[c] => ADP[c] + CDP[c] Pyrimidine metabolism +r_1704 cytidylate kinase (dCMP) ATP[c] + dCMP[c] <=> ADP[c] + dCDP[c] Pyrimidine metabolism +r_1705 cytosine exchange cytosine[e] => Exchange reaction +r_1706 D-arabinose exchange D-arabinose[e] => Exchange reaction +r_1707 D-arabinose transport D-arabinose[e] <=> D-arabinose[c] YDR342C or YHR092C Transport [c, e] +r_1708 D-erythrose 4-phosphate transport D-erythrose 4-phosphate[c] <=> D-erythrose 4-phosphate[m] Transport [c, m] +r_1709 D-fructose exchange D-fructose[e] => Exchange reaction +r_1710 D-galactose exchange D-galactose[e] => Exchange reaction +r_1711 D-galacturonate exchange D-galacturonate[e] => Exchange reaction +r_1712 D-glucitol exchange D-glucitol[e] => Exchange reaction +r_1713 D-glucosamine 6-phosphate uniport alpha-D-glucosamine 6-phosphate[e] <=> alpha-D-glucosamine 6-phosphate[c] Transport [c, e] +r_1714 D-glucose exchange D-glucose[e] <=> Exchange reaction +r_1715 D-mannose exchange D-mannose[e] => Exchange reaction +r_1716 D-ribose exchange D-ribose[e] => Exchange reaction +r_1717 D-sorbitol transport D-glucitol[e] <=> D-glucitol[c] YDL245C or YEL069C or YJR158W or YNR072W Transport [c, e] +r_1718 D-xylose exchange D-xylose[e] => Exchange reaction +r_1719 D-xylose transport D-xylose[e] <=> D-xylose[c] YHR092C Transport [c, e] +r_1720 dADP transport dADP[c] <=> dADP[n] Transport [c, n] +r_1721 dCDP transport dCDP[c] <=> dCDP[n] Transport [c, n] +r_1722 ATP deamination ATP[c] + H+[c] + H2O[c] => ammonium[c] + ITP[c] Purine metabolism +r_1723 dATP deamination dATP[c] + H+[c] + H2O[c] => ammonium[c] + dITP[c] Purine metabolism +r_1724 ADP deamination ADP[c] + H+[c] + H2O[c] => ammonium[c] + IDP[c] Purine metabolism +r_1725 dADP deamination dADP[c] + H+[c] + H2O[c] => ammonium[c] + dIDP[c] Purine metabolism +r_1726 deamino-NAD+ diffusion deamido-NAD(+)[c] <=> deamido-NAD(+)[n] Transport [c, n] +r_1727 decanoate exchange decanoate[e] => Exchange reaction +r_1728 deoxyadenosine transport 2'-deoxyadenosine[e] => 2'-deoxyadenosine[c] Transport [c, e] +r_1729 deoxyadenylate kinase ATP[c] + dAMP[c] <=> ADP[c] + dADP[c] YDL166C Purine metabolism +r_1730 deoxycytidine exchange deoxycytidine[e] => Exchange reaction +r_1731 deoxycytidine transport deoxycytidine[e] => deoxycytidine[c] Transport [c, e] +r_1732 deoxyguanosine transport 2'-deoxyguanosine[e] => 2'-deoxyguanosine[c] Transport [c, e] +r_1733 deoxyinosine transport 2'-deoxyinosine[e] => 2'-deoxyinosine[c] Transport [c, e] +r_1734 deoxyuridine kinase (ATP:deoxyuridine) 2'-deoxyuridine[c] + ATP[c] => ADP[c] + dUMP[c] + H+[c] Pyrimidine metabolism +r_1735 deoxyuridine transport 2'-deoxyuridine[e] => 2'-deoxyuridine[c] YBL042C Transport [c, e] +r_1736 dephospho-CoA kinase 3'-dephospho-CoA[c] + ATP[c] => ADP[c] + coenzyme A[c] + H+[c] Pantothenate and coa biosynthesis +r_1737 dGDP transport dGDP[c] <=> dGDP[n] Transport [c, n] +r_1738 dhnpt transport 7,8-dihydroneopterin[c] <=> 7,8-dihydroneopterin[m] Transport [c, m] +r_1739 diamine transaminase acetyl-CoA[c] + spermine[c] => coenzyme A[c] + H+[c] + N(1)-acetylspermine[c] YDR071C Arginine and proline metabolism +r_1743 dihydrofolate transport dihydrofolic acid[c] <=> dihydrofolic acid[m] Transport [c, m] +r_1744 dihydroneopterin triphosphate pyrophosphatase 7,8-dihydroneopterin 3'-triphosphate[c] + H2O[c] => 7,8-dihydroneopterin 3'-phosphate[c] + diphosphate[c] + H+[c] Folate biosynthesis +r_1745 dihydropteroate transport 7,8-dihydropteroate[c] <=> 7,8-dihydropteroate[m] Transport [c, m] +r_1746 dihydroxyacetone phosphate transport dihydroxyacetone phosphate[m] <=> dihydroxyacetone phosphate[c] Transport [c, m] +r_1747 diphosphate transport diphosphate[c] <=> diphosphate[p] Transport [c, p] +r_1748 dolichol phosphate transport dolichyl phosphate[c] <=> dolichyl phosphate[er] Transport [c, er] +r_1749 dTTP exchange dTTP[e] => Exchange reaction +r_1750 dTTP uniport dTTP[e] <=> dTTP[c] Transport [c, e] +r_1751 dUDP diffusion dUDP[c] <=> dUDP[n] Transport [c, n] +r_1752 dUMP transport dUMP[c] <=> dUMP[n] Transport [c, n] +r_1753 episterol exchange episterol[e] => Exchange reaction +r_1754 ergosta-5,6,22,24,(28)-tetraen-3beta-ol transport ergosta-5,7,22,24(28)-tetraen-3beta-ol[c] <=> ergosta-5,7,22,24(28)-tetraen-3beta-ol[er] Transport [c, er] +r_1757 ergosterol exchange ergosterol[e] => Exchange reaction +r_1758 ergosterol transport ergosterol[er] <=> ergosterol[c] Transport [c, er] +r_1759 ergosterol transport ergosterol[c] <=> ergosterol[lp] Transport [c, lp] +r_1761 ethanol exchange ethanol[e] => Exchange reaction +r_1762 ethanol transport ethanol[c] <=> ethanol[e] Transport [c, e] +r_1763 ethanol transport, mitochondrial ethanol[c] <=> ethanol[m] Transport [c, m] +r_1764 ethanolamine exchange ethanolamine[e] => Exchange reaction +r_1765 ethyl acetate exchange ethyl acetate[e] => Exchange reaction +r_1766 farnesyl diphosphate transport farnesyl diphosphate[c] <=> farnesyl diphosphate[m] Transport [c, m] +r_1770 fatty acid transport decanoate[c] <=> decanoate[p] Transport [c, p] +r_1771 fatty acid transport laurate[c] <=> laurate[p] YKL188C and YPL147W Transport [c, p] +r_1772 fatty acid transport myristate[c] <=> myristate[p] YKL188C and YPL147W Transport [c, p] +r_1774 fatty acid transport palmitate[c] <=> palmitate[p] YKL188C and YPL147W Transport [c, p] +r_1775 fatty acid transport palmitoleate[c] <=> palmitoleate[p] Transport [c, p] +r_1776 fatty acid transport octanoate[c] <=> octanoate[p] Transport [c, p] +r_1777 myristate (n-C14:0) transport myristate[e] <=> myristate[c] Transport [c, e] +r_1788 fecosterol exchange fecosterol[e] => Exchange reaction +r_1790 FMN adenylyltransferase ATP[m] + FMN[m] + H+[m] => diphosphate[m] + FAD[m] YDL045C Riboflavin metabolism +r_1791 FMN exchange FMN[e] => Exchange reaction +r_1792 folic acid exchange folate[e] => Exchange reaction +r_1793 formate exchange formate[e] => Exchange reaction +r_1794 formate transport formate[m] => formate[c] Transport [c, m] +r_1795 formate transport formate[e] <=> formate[c] YNL065W Transport [c, e] +r_1796 formate transport fumarate[e] <=> fumarate[c] Transport [c, e] +r_1797 fructose-1-phosphate kinase ATP[c] + D-fructose 1-phosphate[c] => ADP[c] + D-fructose 1,6-bisphosphate[c] + H+[c] Fructose and mannose metabolism +r_1798 fumarate exchange fumarate[e] => Exchange reaction +r_1800 gamma-aminobutyrate exchange gamma-aminobutyrate[e] => Exchange reaction +r_1801 GDP transport GDP[g] <=> GDP[c] Transport [c, g] +r_1802 GDP transport GDP[c] <=> GDP[n] Transport [c, n] +r_1803 GDP-alpha-D-mannose transport GDP-alpha-D-mannose[c] <=> GDP-alpha-D-mannose[g] YGL225W Transport [c, g] +r_1805 glucose transport, vacuolar D-glucose[c] <=> D-glucose[v] YBR241C or YGL104C Transport [c, v] +r_1806 glutathione disulfide exchange glutathione disulfide[e] => Exchange reaction +r_1807 glutathione exchange glutathione[e] => Exchange reaction +r_1808 glycerol exchange glycerol[e] => Exchange reaction +r_1809 glycerol-3-phosphate shuttle glycerol 3-phosphate[c] <=> glycerol 3-phosphate[m] Transport [c, m] +r_1810 L-glycine exchange L-glycine[e] => Exchange reaction +r_1811 glycine transport L-glycine[c] <=> L-glycine[m] YPR058W Transport [c, m] +r_1812 glycoaldehyde transport glycolaldehyde[c] <=> glycolaldehyde[m] Transport [c, m] +r_1813 glycoaldehyde transport glycolaldehyde[e] <=> glycolaldehyde[c] Transport [c, e] +r_1814 glycolaldehyde exchange glycolaldehyde[e] => Exchange reaction +r_1815 glyoxylate exchange glyoxylate[e] => Exchange reaction +r_1816 glyoxylate transport glyoxylate[c] <=> glyoxylate[e] YNL065W Transport [c, e] +r_1817 glyoxylate transport glyoxylate[c] <=> glyoxylate[p] Transport [c, p] +r_1818 guanine exchange guanine[e] => Exchange reaction +r_1819 guanine transport guanine[c] <=> guanine[m] Transport [c, m] +r_1820 guanosine exchange guanosine[e] => Exchange reaction +r_1821 guanosine kinase ATP[c] + guanosine[c] => ADP[c] + GMP[c] + H+[c] Purine metabolism +r_1822 guanosine transport guanosine[c] => guanosine[m] Transport [c, m] +r_1823 guanosine transport guanosine[e] => guanosine[c] Transport [c, e] +r_1824 H+ diffusion H+[e] => H+[c] Transport [c, e] +r_1825 H+ diffusion H+[c] <=> H+[er] Transport [c, er] +r_1826 H+ diffusion H+[c] <=> H+[g] Transport [c, g] +r_1827 H+ diffusion H+[c] <=> H+[lp] Transport [c, lp] +r_1829 H+ diffusion H+[c] <=> H+[n] Transport [c, n] +r_1830 H+ diffusion H+[c] <=> H+[p] Transport [c, p] +r_1831 H+ diffusion H+[c] <=> H+[v] Transport [c, v] +r_1832 H+ exchange H+[e] <=> Exchange reaction +r_1833 hexacosanoyl-CoA transport hexacosanoyl-CoA[c] <=> hexacosanoyl-CoA[er] Transport [c, er] +r_1834 hexadecanal exchange hexadecanal[e] => Exchange reaction +r_1835 hexadecanoate (n-C16:0) transport palmitate[e] <=> palmitate[c] Transport [c, e] +r_1836 hexadecenoate (n-C16:1) transport palmitoleate[e] <=> palmitoleate[c] Transport [c, e] +r_1837 L-histidine transport, mitochondrial L-histidine[c] => L-histidine[m] YBR147W Transport [c, m] +r_1838 homocitrate synthase 2-oxoglutarate[m] + acetyl-CoA[m] + H2O[m] => coenzyme A[m] + H+[m] + homocitrate[m] YDL131W or YDL182W Pyruvate metabolism +r_1839 hydrogen peroxide transport hydrogen peroxide[c] <=> hydrogen peroxide[n] Transport [c, n] +r_1840 hydroxymethylglutaryl-CoA transport 3-hydroxy-3-methylglutaryl-CoA[c] <=> 3-hydroxy-3-methylglutaryl-CoA[m] Transport [c, m] +r_1841 hypoxanthine exchange hypoxanthine[e] => Exchange reaction +r_1842 hypoxanthine transport hypoxanthine[e] <=> hypoxanthine[c] Transport [c, e] +r_1843 indol-3-ylacetaldehyde exchange indol-3-ylacetaldehyde[e] => Exchange reaction +r_1844 indole-3-acetaldehyde transport indol-3-ylacetaldehyde[c] <=> indol-3-ylacetaldehyde[m] Transport [c, m] +r_1845 indole-3-acetaldehyde transport indol-3-ylacetaldehyde[c] <=> indol-3-ylacetaldehyde[e] Transport [c, e] +r_1846 indole-3-acetate transport indole-3-acetate[c] <=> indole-3-acetate[m] Transport [c, m] +r_1847 inosine exchange inosine[e] => Exchange reaction +r_1848 inosine transport inosine[e] => inosine[c] Transport [c, e] +r_1849 inositol hexakisphosphate transport myo-inositol hexakisphosphate[c] <=> myo-inositol hexakisphosphate[n] Transport [c, n] +r_1850 insosine kinase ATP[c] + inosine[c] => ADP[c] + H+[c] + IMP[c] Purine metabolism +r_1851 IPC transport inositol-P-ceramide A (C24)[g] <=> inositol-P-ceramide A (C24)[er] Transport [er, g] +r_1852 IPC transport inositol-P-ceramide B (C24)[g] <=> inositol-P-ceramide B (C24)[er] Transport [er, g] +r_1853 IPC transport inositol-P-ceramide B' (C24)[g] <=> inositol-P-ceramide B' (C24)[er] Transport [er, g] +r_1854 IPC transport inositol-P-ceramide C (C24)[g] <=> inositol-P-ceramide C (C24)[er] Transport [er, g] +r_1855 IPC transport inositol-P-ceramide D (C24)[g] <=> inositol-P-ceramide D (C24)[er] Transport [er, g] +r_1856 IPC transport inositol-P-ceramide A (C26)[g] <=> inositol-P-ceramide A (C26)[er] Transport [er, g] +r_1857 IPC transport inositol-P-ceramide B (C26)[g] <=> inositol-P-ceramide B (C26)[er] Transport [er, g] +r_1858 IPC transport inositol-P-ceramide B' (C26)[g] <=> inositol-P-ceramide B' (C26)[er] Transport [er, g] +r_1859 IPC transport inositol-P-ceramide C (C26)[g] <=> inositol-P-ceramide C (C26)[er] Transport [er, g] +r_1860 IPC transport inositol-P-ceramide D (C26)[g] <=> inositol-P-ceramide D (C26)[er] Transport [er, g] +r_1861 iron(2+) exchange iron(2+)[e] <=> Exchange reaction +r_1862 isoamyl acetate exchange isoamyl acetate[e] => Exchange reaction +r_1863 isoamyl alcohol transport isoamylol[c] <=> isoamylol[e] Transport [c, e] +r_1864 isoamyl alcohol transport isoamylol[c] <=> isoamylol[m] Transport [c, m] +r_1865 isoamylol exchange isoamylol[e] => Exchange reaction +r_1866 isobutanol exchange isobutanol[e] => Exchange reaction +r_1867 isobutyl acetate exchange isobutyl acetate[e] => Exchange reaction +r_1868 isobutyl alcohol transport isobutanol[c] <=> isobutanol[e] Transport [c, e] +r_1869 isobutyl alcohol transport isobutanol[c] <=> isobutanol[m] Transport [c, m] +r_1870 isobutyraldehyde exchange isobutyraldehyde[e] => Exchange reaction +r_1871 L-1-pyrroline-3-hydroxy-5-carboxylate spontaneous conversion to L-4-hydroxyglutamate semialdehyde 1-pyrroline-3-hydroxy-5-carboxylic acid[m] + H+[m] + H2O[m] => L-4-hydroxyglutamic semialdehyde[m] Arginine and proline metabolism +r_1872 L-2-amino-3-oxobutanoate decarboxylation (spontaneous) H+[c] + L-2-amino-3-oxobutanoate[c] => aminoacetone[c] + carbon dioxide[c] Glycine, serine and threonine metabolism +r_1873 L-alanine exchange L-alanine[e] => Exchange reaction +r_1874 L-alanine transport L-alanine[m] => L-alanine[c] Transport [c, m] +r_1875 L-arabinitol exchange L-arabinitol[e] => Exchange reaction +r_1876 L-arabinitol transport L-arabinitol[e] <=> L-arabinitol[c] Transport [c, e] +r_1877 L-arabinoase transport L-arabinose[e] <=> L-arabinose[c] YDR342C or YHR092C Transport [c, e] +r_1878 L-arabinose exchange L-arabinose[e] => Exchange reaction +r_1879 L-arginine exchange L-arginine[e] => Exchange reaction +r_1880 L-asparagine exchange L-asparagine[e] => Exchange reaction +r_1881 L-aspartate exchange L-aspartate[e] => Exchange reaction +r_1882 L-carnitine transport (R)-carnitine[m] => (R)-carnitine[c] YOR100C Transport [c, m] +r_1883 L-cysteine exchange L-cysteine[e] => Exchange reaction +r_1884 L-erythro-4-hydroxyglutamate transport erythro-4-hydroxy-L-glutamic acid[c] <=> erythro-4-hydroxy-L-glutamic acid[m] Transport [c, m] +r_1885 L-erythro-4-hydroxyglutamate transport erythro-4-hydroxy-L-glutamic acid[c] <=> erythro-4-hydroxy-L-glutamic acid[p] Transport [c, p] +r_1886 L-glucitol exchange L-glucitol[e] => Exchange reaction +r_1887 L-glutamate 5-semialdehyde dehydratase L-glutamic 5-semialdehyde[c] <=> 1-pyrroline-5-carboxylate[c] + H+[c] + H2O[c] Arginine and proline metabolism +r_1889 L-glutamate exchange L-glutamate[e] => Exchange reaction +r_1890 L-glutamate transport L-glutamate[c] <=> L-glutamate[n] Transport [c, n] +r_1891 L-glutamine exchange L-glutamine[e] => Exchange reaction +r_1892 L-glutamine transport L-glutamine[c] <=> L-glutamine[n] Transport [c, n] +r_1893 L-histidine exchange L-histidine[e] => Exchange reaction +r_1895 L-homoserine transport L-homoserine[e] <=> L-homoserine[c] Transport [c, e] +r_1896 L-homoserine exchange L-homoserine[e] => Exchange reaction +r_1897 L-isoleucine exchange L-isoleucine[e] => Exchange reaction +r_1898 L-isoleucine transport L-isoleucine[m] => L-isoleucine[c] Transport [c, m] +r_1899 L-leucine exchange L-leucine[e] => Exchange reaction +r_1900 L-lysine exchange L-lysine[e] => Exchange reaction +r_1901 L-malate transport (S)-malate[e] <=> (S)-malate[c] Transport [c, e] +r_1902 L-methionine exchange L-methionine[e] => Exchange reaction +r_1903 L-phenylalanine exchange L-phenylalanine[e] => Exchange reaction +r_1904 L-proline exchange L-proline[e] => Exchange reaction +r_1905 L-proline transport L-proline[c] <=> L-proline[m] Transport [c, m] +r_1906 L-serine exchange L-serine[e] => Exchange reaction +r_1907 L-serine transport L-serine[c] <=> L-serine[er] YKR039W Transport [c, er] +r_1908 L-sorbitol transport L-glucitol[e] <=> L-glucitol[c] YDL245C or YEL069C or YJR158W or YNR072W Transport [c, e] +r_1909 L-sorbose exchange L-sorbose[e] => Exchange reaction +r_1910 L-sorbose transport L-sorbose[e] <=> L-sorbose[c] YDL245C or YDR342C or YDR343C or YDR345C or YEL069C or YFL011W or YHR092C or YHR094C or YHR096C or YJL214W or YJL219W or YJR158W or YMR011W or YNR072W or YOL156W Transport [c, e] +r_1911 L-threonine exchange L-threonine[e] => Exchange reaction +r_1912 L-tryptophan exchange L-tryptophan[e] => Exchange reaction +r_1913 L-tyrosine exchange L-tyrosine[e] => Exchange reaction +r_1914 L-valine exchange L-valine[e] => Exchange reaction +r_1915 lanosterol exchange lanosterol[e] => Exchange reaction +r_1916 laurate exchange laurate[e] => Exchange reaction +r_1919 lysine transport L-lysine[c] => L-lysine[m] YBR147W Transport [c, m] +r_1920 M(IP)2C transport inositol phosphomannosylinositol phosphoceramide A (C24)[g] <=> inositol phosphomannosylinositol phosphoceramide A (C24)[er] Transport [er, g] +r_1921 M(IP)2C transport inositol phosphomannosylinositol phosphoceramide B (C24)[g] <=> inositol phosphomannosylinositol phosphoceramide B (C24)[er] Transport [er, g] +r_1922 M(IP)2C transport inositol phosphomannosylinositol phosphoceramide B' (C24)[g] <=> inositol phosphomannosylinositol phosphoceramide B' (C24)[er] Transport [er, g] +r_1923 M(IP)2C transport inositol phosphomannosylinositol phosphoceramide C (C24)[g] <=> inositol phosphomannosylinositol phosphoceramide C (C24)[er] Transport [er, g] +r_1924 M(IP)2C transport inositol phosphomannosylinositol phosphoceramide D (C24)[g] <=> inositol phosphomannosylinositol phosphoceramide D (C24)[er] Transport [er, g] +r_1925 M(IP)2C transport inositol phosphomannosylinositol phosphoceramide A (C26)[g] <=> inositol phosphomannosylinositol phosphoceramide A (C26)[er] Transport [er, g] +r_1926 M(IP)2C transport inositol phosphomannosylinositol phosphoceramide B (C26)[g] <=> inositol phosphomannosylinositol phosphoceramide B (C26)[er] Transport [er, g] +r_1927 M(IP)2C transport inositol phosphomannosylinositol phosphoceramide B' (C26)[g] <=> inositol phosphomannosylinositol phosphoceramide B' (C26)[er] Transport [er, g] +r_1928 M(IP)2C transport inositol phosphomannosylinositol phosphoceramide C (C26)[g] <=> inositol phosphomannosylinositol phosphoceramide C (C26)[er] Transport [er, g] +r_1929 M(IP)2C transport inositol phosphomannosylinositol phosphoceramide D (C26)[g] <=> inositol phosphomannosylinositol phosphoceramide D (C26)[er] Transport [er, g] +r_1930 malate/oxaloacetate shuttle (S)-malate[p] + oxaloacetate[c] <=> (S)-malate[c] + oxaloacetate[p] Transport [c, p] +r_1931 maltose exchange maltose[e] => Exchange reaction +r_1932 mannan transport mannan[c] <=> mannan[er] Transport [c, er] +r_1935 methionine transport L-methionine[m] => L-methionine[c] YDR508C Transport [c, m] +r_1936 methylglyoxal synthase dihydroxyacetone phosphate[c] => methylglyoxal[c] + phosphate[c] Propanoate metabolism +r_1937 MIPC transport mannosylinositol phosphorylceramide A (C24)[g] <=> mannosylinositol phosphorylceramide A (C24)[er] Transport [er, g] +r_1938 MIPC transport mannosylinositol phosphorylceramide B (C24)[g] <=> mannosylinositol phosphorylceramide B (C24)[er] Transport [er, g] +r_1939 MIPC transport mannosylinositol phosphorylceramide B' (C24)[g] <=> mannosylinositol phosphorylceramide B' (C24)[er] Transport [er, g] +r_1940 MIPC transport mannosylinositol phosphorylceramide C (C24)[g] <=> mannosylinositol phosphorylceramide C (C24)[er] Transport [er, g] +r_1941 MIPC transport mannosylinositol phosphorylceramide D (C24)[g] <=> mannosylinositol phosphorylceramide D (C24)[er] Transport [er, g] +r_1942 MIPC transport mannosylinositol phosphorylceramide A (C26)[g] <=> mannosylinositol phosphorylceramide A (C26)[er] Transport [er, g] +r_1943 MIPC transport mannosylinositol phosphorylceramide B (C26)[g] <=> mannosylinositol phosphorylceramide B (C26)[er] Transport [er, g] +r_1944 MIPC transport mannosylinositol phosphorylceramide B' (C26)[g] <=> mannosylinositol phosphorylceramide B' (C26)[er] Transport [er, g] +r_1945 MIPC transport mannosylinositol phosphorylceramide C (C26)[g] <=> mannosylinositol phosphorylceramide C (C26)[er] Transport [er, g] +r_1946 MIPC transport mannosylinositol phosphorylceramide D (C26)[g] <=> mannosylinositol phosphorylceramide D (C26)[er] Transport [er, g] +r_1947 myo-inositol exchange myo-inositol[e] => Exchange reaction +r_1952 N,N'-diformyldityrosine exchange N,N'-diformyldityrosine[e] => Exchange reaction +r_1963 NADP(+) transport NADP(+)[c] <=> NADP(+)[er] Transport [c, er] +r_1964 NADPH transport NADPH[c] <=> NADPH[er] Transport [c, er] +r_1965 NH3 transport ammonium[c] <=> ammonium[m] Transport [c, m] +r_1966 nicotinamide diffusion nicotinamide[c] <=> nicotinamide[n] Transport [c, n] +r_1967 nicotinate exchange nicotinate[e] => Exchange reaction +r_1968 NMN exchange NMN[e] => Exchange reaction +r_1970 NMN transport NMN[c] <=> NMN[n] Transport [c, n] +r_1971 NMN transport NMN[c] <=> NMN[p] Transport [c, p] +r_1972 NMN transport NMN[e] => NMN[c] Transport [c, e] +r_1974 nucleoside-diphosphatase (dGDP) dGDP[c] + H2O[c] => dGMP[c] + H+[c] + phosphate[c] Purine metabolism +r_1975 nucleoside-triphosphatase (dGTP) dGTP[c] + H2O[c] => dGDP[c] + H+[c] + phosphate[c] Purine metabolism +r_1976 O-acetylcarnintine transport into mitochondria O-acetylcarnitine[c] => O-acetylcarnitine[m] YOR100C Transport [c, m] +r_1977 O2 transport oxygen[c] <=> oxygen[er] Transport [c, er] +r_1978 O2 transport oxygen[c] <=> oxygen[m] Transport [c, m] +r_1979 O2 transport oxygen[e] <=> oxygen[c] Transport [c, e] +r_1980 O2 transport oxygen[c] <=> oxygen[p] Transport [c, p] +r_1981 octadecanoate (n-C18:0) transport stearate[e] <=> stearate[c] Transport [c, e] +r_1984 octanoate exchange octanoate[e] => Exchange reaction +r_1987 ornithine exchange ornithine[e] => Exchange reaction +r_1988 oxaloacetate transport oxaloacetate[c] <=> oxaloacetate[e] Transport [c, e] +r_1989 oxaloacetate(2-) exchange oxaloacetate[e] => Exchange reaction +r_1990 oxidized glutathione uniport glutathione disulfide[e] => glutathione disulfide[c] YJL212C Transport [c, e] +r_1991 oxidized thioredoxin transport TRX1 disulphide[c] <=> TRX1 disulphide[p] Transport [c, p] +r_1992 oxygen exchange oxygen[e] <=> Exchange reaction +r_1993 palmitate exchange palmitate[e] => Exchange reaction +r_1994 palmitoleate exchange palmitoleate[e] => Exchange reaction +r_1995 palmitoyl-CoA transport palmitoyl-CoA[c] <=> palmitoyl-CoA[er] Transport [c, er] +r_1996 panthetheine 4'-phosphate transport pantetheine 4'-phosphate[c] <=> pantetheine 4'-phosphate[m] Transport [c, m] +r_1997 panthetheine-phosphate adenylyltransferase ATP[m] + H+[m] + pantetheine 4'-phosphate[m] => 3'-dephospho-CoA[m] + diphosphate[m] Pantothenate and coa biosynthesis +r_1998 PAP uniport adenosine 3',5'-bismonophosphate[e] <=> adenosine 3',5'-bismonophosphate[c] Transport [c, e] +r_1999 pectin exchange pectin[e] => Exchange reaction +r_2000 phenethyl acetate exchange phenethyl acetate[e] => Exchange reaction +r_2001 phenylacetaldehyde exchange phenylacetaldehyde[e] => Exchange reaction +r_2002 phenylacetaldehyde transport phenylacetaldehyde[c] <=> phenylacetaldehyde[e] Transport [c, e] +r_2003 phenylacetaldehyde transport phenylacetaldehyde[c] <=> phenylacetaldehyde[m] Transport [c, m] +r_2004 phenylalanine transport L-phenylalanine[c] => L-phenylalanine[m] Transport [c, m] +r_2005 phosphate exchange phosphate[e] <=> Exchange reaction +r_2008 phosphate transport phosphate[c] <=> phosphate[v] YNR013C Transport [c, v] +r_2020 potassium exchange potassium[e] <=> Exchange reaction +r_2022 protoporphyrinogen IX transport protoporphyrinogen[c] <=> protoporphyrinogen[m] Transport [c, m] +r_2023 PRPP transport PRPP[c] <=> PRPP[m] Transport [c, m] +r_2024 putrescine exchange putrescine[e] => Exchange reaction +r_2025 pyridoxal kinase ATP[c] + pyridoxal[c] => ADP[c] + H+[c] + pyridoxal 5'-phosphate[c] YNR027W Vitamin b6 metabolism +r_2026 pyridoxamine kinase ATP[c] + pyridoxamine[c] => ADP[c] + H+[c] + pyridoxamine 5'-phosphate[c] Vitamin b6 metabolism +r_2027 pyridoxamine phosphatase H2O[c] + pyridoxamine 5'-phosphate[c] => phosphate[c] + pyridoxamine[c] Vitamin b6 metabolism +r_2028 pyridoxine exchange pyridoxine[e] => Exchange reaction +r_2029 pyridoxine kinase ATP[c] + pyridoxine[c] => ADP[c] + H+[c] + pyridoxine 5'-phosphate[c] YEL029C Vitamin b6 metabolism +r_2030 pyrimidine phosphatase 5-amino-6-(5-phosphoribitylamino)uracil[c] + H2O[c] => 5-amino-6-(D-ribitylamino)uracil[c] + phosphate[c] Riboflavin metabolism +r_2031 pyrimidine-nucleoside phosphorylase (uracil) phosphate[c] + uridine[c] <=> alpha-D-ribose 1-phosphate(2-)[c] + uracil[c] Pyrimidine metabolism +r_2032 pyrophosphate transport diphosphate[c] <=> diphosphate[m] Transport [c, m] +r_2033 pyruvate exchange pyruvate[e] => Exchange reaction +r_2034 pyruvate transport H+[c] + pyruvate[c] => H+[m] + pyruvate[m] (YGL080W and YGR243W) or (YGL080W and YHR162W) Transport [c, m] +r_2036 quinolinate transport quinolinate[c] <=> quinolinate[m] Transport [c, m] +r_2037 reduced thioredoxin transport TRX1[c] <=> TRX1[p] Transport [c, p] +r_2038 riboflavin exchange riboflavin[e] => Exchange reaction +r_2039 riboflavin transport riboflavin[c] => riboflavin[m] Transport [c, m] +r_2040 riboflavin transport riboflavin[e] => riboflavin[c] YOR306C Transport [c, e] +r_2041 ribose transporter D-ribose[e] => D-ribose[c] YDR342C or YHR092C Transport [c, e] +r_2042 S-adenosyl-L-homocysteine transport S-adenosyl-L-homocysteine[c] <=> S-adenosyl-L-homocysteine[m] Transport [c, m] +r_2043 S-adenosyl-L-methionine exchange S-adenosyl-L-methionine[e] => Exchange reaction +r_2044 S-methyl-L-methionine exchange S-methyl-L-methionine[e] => Exchange reaction +r_2045 serine transport L-serine[c] <=> L-serine[m] YDR508C Transport [c, m] +r_2046 sn-glycero-3-phosphocholine exchange sn-glycero-3-phosphocholine[e] => Exchange reaction +r_2049 sodium exchange sodium[e] <=> Exchange reaction +r_2050 spermidine acetyltransferase acetyl-CoA[c] + spermidine[c] => coenzyme A[c] + H+[c] + N(1)-acetylspermidine[c] Arginine and proline metabolism +r_2051 spermidine exchange spermidine[e] => Exchange reaction +r_2052 spermine exchange spermine[e] => Exchange reaction +r_2053 squalene transport squalene[c] <=> squalene[er] Transport [c, er] +r_2054 squalene-2,3-epoxide transport (S)-2,3-epoxysqualene[er] <=> (S)-2,3-epoxysqualene[c] Transport [c, er] +r_2055 stearate exchange stearate[e] => Exchange reaction +r_2056 succinate exchange succinate[e] => Exchange reaction +r_2057 succinate transport succinate[e] <=> succinate[c] Transport [c, e] +r_2058 sucrose exchange sucrose[e] => Exchange reaction +r_2060 sulphate exchange sulphate[e] <=> Exchange reaction +r_2061 sulphite exchange sulphite[e] => Exchange reaction +r_2062 taurine exchange taurine[e] => Exchange reaction +r_2063 tetracosanoyl-CoA transport tetracosanoyl-CoA[c] <=> tetracosanoyl-CoA[er] Transport [c, er] +r_2064 thiamin phosphatase H2O[c] + TMP[c] => phosphate[c] + thiamine[c] YDL024C Thiamine metabolism +r_2065 thiaminase H2O[c] + thiamine[c] => 4-amino-5-hydroxymethyl-2-methylpyrimidine[c] + 5-(2-hydroxyethyl)-4-methylthiazole[c] + H+[c] Thiamine metabolism +r_2066 thiamine(1+) diphosphate(1-) exchange TDP[e] => Exchange reaction +r_2067 thiamine(1+) exchange thiamine[e] => Exchange reaction +r_2068 thiamine(1+) monophosphate exchange TMP[e] => Exchange reaction +r_2069 thiamine-phosphate kinase ATP[c] + TMP[c] => ADP[c] + TDP[c] Thiamine metabolism +r_2070 thiazole phosphate synthesis (ribose 5-phosphate) H+[c] + L-cysteine[c] + L-glycine[c] + O-acetyl-L-homoserine[c] + ribose-5-phosphate[c] => 4-methyl-5-(2-phosphonooxyethyl)thiazole[c] + acetate[c] + ammonium[c] + carbon dioxide[c] + gamma-aminobutyrate[c] + 3 H2O[c] + pyruvate[c] Thiamine metabolism r_1036 +r_2071 thiazole phosphate synthesis (xylulose 5-phosphate) D-xylulose 5-phosphate[c] + H+[c] + L-cysteine[c] + L-glycine[c] + O-acetyl-L-homoserine[c] => 4-methyl-5-(2-phosphonooxyethyl)thiazole[c] + acetate[c] + ammonium[c] + carbon dioxide[c] + gamma-aminobutyrate[c] + 3 H2O[c] + pyruvate[c] Thiamine metabolism r_1036 +r_2072 threonine transport L-threonine[c] => L-threonine[m] YDR508C Transport [c, m] +r_2073 thymidine exchange thymidine[e] => Exchange reaction +r_2074 thymidine kinase (ATP:thymidine) ATP[c] + thymidine[c] => ADP[c] + dTMP[c] + H+[c] Pyrimidine metabolism +r_2075 thymidine transport thymidine[e] <=> thymidine[c] Transport [c, e] +r_2079 trehalose transporter H+[c] + trehalose[c] <=> H+[e] + trehalose[e] YGR289C Transport [c, e] +r_2080 trehalose vacuolar transport trehalose[c] <=> trehalose[v] Transport [c, v] +r_2082 tryptophan transport L-tryptophan[c] => L-tryptophan[m] Transport [c, m] +r_2083 tryptophol exchange tryptophol[e] => Exchange reaction +r_2084 tryptophol transport tryptophol[c] <=> tryptophol[e] Transport [c, e] +r_2085 tryptophol transport tryptophol[c] <=> tryptophol[m] Transport [c, m] +r_2086 tyrosine transport L-tyrosine[c] => L-tyrosine[m] Transport [c, m] +r_2087 tyrosine transport L-tyrosine[c] <=> L-tyrosine[p] Transport [c, p] +r_2089 UMP transport UMP[c] <=> UMP[n] Transport [c, n] +r_2090 uracil exchange uracil[e] => Exchange reaction +r_2091 urea exchange urea[e] => Exchange reaction +r_2092 uridine exchange uridine[e] => Exchange reaction +r_2093 valine transport L-valine[c] <=> L-valine[m] Transport [c, m] +r_2094 water diffusion H2O[c] <=> H2O[er] YLL052C or YPR192W Transport [c, er] +r_2095 water diffusion H2O[c] <=> H2O[g] Transport [c, g] +r_2096 water diffusion H2O[c] <=> H2O[m] Transport [c, m] +r_2097 water diffusion H2O[c] <=> H2O[n] Transport [c, n] +r_2098 water diffusion H2O[c] <=> H2O[p] Transport [c, p] +r_2099 water diffusion H2O[c] <=> H2O[v] Transport [c, v] +r_2100 water exchange H2O[e] <=> Exchange reaction +r_2101 xanthine transport 9H-xanthine[e] <=> 9H-xanthine[c] Transport [c, e] +r_2102 xanthosine exchange xanthosine[e] => Exchange reaction +r_2103 xanthosine transport xanthosine[e] => xanthosine[c] Transport [c, e] +r_2104 xylitol exchange xylitol[e] => Exchange reaction +r_2105 xylitol transport xylitol[e] <=> xylitol[c] YDL245C or YLL043W Transport [c, e] +r_2106 zymosterol exchange zymosterol[e] => Exchange reaction +r_2107 zymosterol transport zymosterol[ce] <=> zymosterol[c] YIL013C or YOR011W Transport [c, ce] +r_2108 lipid pseudoreaction - merge lipid backbone[c] + lipid chain[c] => lipid[c] Growth +r_2111 growth biomass[c] => Exchange reaction +r_2112 kynurenine aminotransferase L-kynurenine[c] + pyruvate[c] <=> H2O[c] + L-alanine[c] + kynurenic acid[c] YJL060W Tryptophan metabolism +r_2113 spontaneous kynurenic acid to quinaldic acid 2 H+[c] + NADPH[c] + kynurenic acid[c] => H2O[c] + NADP(+)[c] + quinaldic acid[c] Tryptophan metabolism +r_2114 spontaneous 2-amino-3-carboxymuconate-6-semialdehyde to quinolinate 2-amino-3-carboxymuconate-6-semialdehyde[c] => H+[c] + H2O[c] + quinolinate[c] Tryptophan metabolism +r_2115 alcohol dehydrogenase, (acetaldehyde to ethanol) acetaldehyde[c] + H+[c] + NADH[c] => ethanol[c] + NAD[c] YBR145W or YOL086C Glycolysis / gluconeogenesis +r_2116 acetaldehyde dehydrogenase acetaldehyde[c] + H2O[c] + NAD[c] => acetate[c] + 2 H+[c] + NADH[c] YMR110C or YMR170C or YER073W or YOR374W Glycolysis / gluconeogenesis +r_2117 phenylalanine transaminase L-phenylalanine[c] + pyruvate[c] <=> keto-phenylpyruvate[c] + L-alanine[c] YHR137W Phenylalanine, tyrosine and tryptophan biosynthesis +r_2118 tryptophan transaminase keto-phenylpyruvate[c] + L-tryptophan[c] => indole-3-pyruvate[c] + L-phenylalanine[c] YHR137W Phenylalanine, tyrosine and tryptophan biosynthesis +r_2119 tyrosine transaminase 3-(4-hydroxyphenyl)pyruvate[c] + L-alanine[c] <=> L-tyrosine[c] + pyruvate[c] YHR137W Phenylalanine, tyrosine and tryptophan biosynthesis +r_2125 coenzyme A: cytoplasm to LP coenzyme A[c] <=> coenzyme A[lp] Transport [c, lp] +r_2126 sedoheptulose bisphosphatase H2O[c] + sedoheptulose 1,7-bisphosphate[c] => phosphate[c] + sedoheptulose 7-phosphate[c] YKR043C Glycolysis / gluconeogenesis +r_2129 proton leak H+[c] => H+[m] Transport [c, m] +r_2131 isocitrate dehydrogenase isocitrate[m] + NADP(+)[m] => 2-oxoglutarate[m] + carbon dioxide[m] + NADPH[m] YDL066W Citrate cycle (TCA cycle) +r_2132 oxoglutarate/malate exchange (S)-malate[c] + 2-oxoglutarate[m] => (S)-malate[m] + 2-oxoglutarate[c] YOR222W or YPL134C Transport [c, m] +r_2134 14-demethyllanosterol exchange 14-demethyllanosterol[e] => Exchange reaction +r_2136 14-demethyllanosterol transport 14-demethyllanosterol[e] <=> 14-demethyllanosterol[c] Transport [c, e] +r_2137 ergosta-5,7,22,24(28)-tetraen-3beta-ol exchange ergosta-5,7,22,24(28)-tetraen-3beta-ol[e] => Exchange reaction +r_2139 ergosta-5,7,22,24(28)-tetraen-3beta-ol transport ergosta-5,7,22,24(28)-tetraen-3beta-ol[e] <=> ergosta-5,7,22,24(28)-tetraen-3beta-ol[c] Transport [c, e] +r_2140 fatty-acyl-CoA synthase (n-C16:0CoA) acetyl-CoA[c] + 21 H+[c] + 7 malonyl-CoA[c] + 14 NADPH[c] => 7 carbon dioxide[c] + 7 coenzyme A[c] + 7 H2O[c] + 14 NADP(+)[c] + palmitoyl-CoA[c] YKL182W and YPL231W Fatty acid biosynthesis +r_2141 fatty-acyl-CoA synthase (n-C18:0CoA) acetyl-CoA[c] + 24 H+[c] + 8 malonyl-CoA[c] + 16 NADPH[c] => 8 carbon dioxide[c] + 8 coenzyme A[c] + 8 H2O[c] + 16 NADP(+)[c] + stearoyl-CoA[c] YKL182W and YPL231W Fatty acid biosynthesis +r_2142 B-ketoacyl-ACP synthase (acetoacetyl-ACP) acetyl-ACP[m] + carboxyacetyl-ACP[m] + H+[m] => carbon dioxide[m] + ACP1[m] + acetoacetyl-ACP[m] YER061C and YKL192C Fatty acid biosynthesis +r_2143 B-ketoacyl-ACP synthase (3-oxo-hexanoyl-ACP) carboxyacetyl-ACP[m] + H+[m] + butanoyl-ACP[m] => carbon dioxide[m] + ACP1[m] + 3-oxo-hexanoyl-ACP[m] YER061C and YKL192C Fatty acid biosynthesis +r_2144 B-ketoacyl-ACP synthase (3-oxo-octanoyl-ACP) carboxyacetyl-ACP[m] + H+[m] + hexanoyl-ACP[m] => carbon dioxide[m] + ACP1[m] + 3-oxo-octanoyl-ACP[m] YER061C and YKL192C Fatty acid biosynthesis +r_2145 3-oxoacyl-ACP reductase (3-hydroxybutanoyl-ACP) H+[m] + NADPH[m] + acetoacetyl-ACP[m] => NADP(+)[m] + 3-hydroxybutanoyl-ACP[m] YKL055C Fatty acid biosynthesis +r_2146 3-oxoacyl-ACP reductase (3-hydroxyhexanoyl-ACP) H+[m] + NADPH[m] + 3-oxo-hexanoyl-ACP[m] => NADP(+)[m] + 3-hydroxyhexanoyl-ACP[m] YKL055C Fatty acid biosynthesis +r_2147 3-oxoacyl-ACP reductase (3-hydroxyoctanoyl-ACP) H+[m] + NADPH[m] + 3-oxo-octanoyl-ACP[m] => NADP(+)[m] + 3-hydroxyoctanoyl-ACP[m] YKL055C Fatty acid biosynthesis +r_2148 3-hydroxyacyl-thioester dehydratase (trans-but-2-enoyl-ACP) 3-hydroxybutanoyl-ACP[m] <=> H2O[m] + trans-but-2-enoyl-ACP[m] YHR067W Fatty acid biosynthesis +r_2149 3-hydroxyacyl-thioester dehydratase (trans-hex-2-enoyl-ACP) 3-hydroxyhexanoyl-ACP[m] <=> H2O[m] + trans-hex-2-enoyl-ACP[m] YHR067W Fatty acid biosynthesis +r_2150 3-hydroxyacyl-thioester dehydratase (trans-oct-2-enoyl-ACP) 3-hydroxyoctanoyl-ACP[m] <=> H2O[m] + trans-oct-2-enoyl-ACP[m] YHR067W Fatty acid biosynthesis +r_2151 enoyl-ACP reductase (butanoyl-ACP) H+[m] + NADPH[m] + trans-but-2-enoyl-ACP[m] => NADP(+)[m] + butanoyl-ACP[m] YBR026C Biosynthesis of unsaturated fatty acids +r_2152 enoyl-ACP reductase (hexanoyl-ACP) H+[m] + NADPH[m] + trans-hex-2-enoyl-ACP[m] => NADP(+)[m] + hexanoyl-ACP[m] YBR026C Biosynthesis of unsaturated fatty acids +r_2153 enoyl-ACP reductase (octanoyl-ACP) H+[m] + NADPH[m] + trans-oct-2-enoyl-ACP[m] => NADP(+)[m] + octanoyl-ACP[m] YBR026C Biosynthesis of unsaturated fatty acids +r_2154 elongase I (3-oxotetradecanoyl-CoA) lauroyl-CoA[erm] + malonyl-CoA[erm] + H+[erm] => carbon dioxide[erm] + coenzyme A[erm] + 3-oxotetradecanoyl-CoA[erm] YJL196C Biosynthesis of unsaturated fatty acids +r_2155 elongase I (3-oxopalmitoyl-CoA) malonyl-CoA[erm] + H+[erm] + myristoyl-CoA[erm] => carbon dioxide[erm] + coenzyme A[erm] + 3-oxopalmitoyl-CoA[erm] YJL196C Biosynthesis of unsaturated fatty acids +r_2156 elongase II (3-oxooctadecanoyl-CoA) malonyl-CoA[erm] + H+[erm] + palmitoyl-CoA[erm] => carbon dioxide[erm] + coenzyme A[erm] + 3-oxooctadecanoyl-CoA[erm] YCR034W Biosynthesis of unsaturated fatty acids +r_2157 elongase II or III (3-oxoicosanoyl-CoA) malonyl-CoA[erm] + H+[erm] + stearoyl-CoA[erm] => carbon dioxide[erm] + coenzyme A[erm] + 3-oxoicosanoyl-CoA[erm] YCR034W or YLR372W Biosynthesis of unsaturated fatty acids +r_2158 elongase II or III (3-oxodocosanoyl-CoA) malonyl-CoA[erm] + H+[erm] + icosanoyl-CoA[erm] => carbon dioxide[erm] + coenzyme A[erm] + 3-oxodocosanoyl-CoA[erm] YCR034W or YLR372W Biosynthesis of unsaturated fatty acids +r_2159 elongase II or III (3-oxotetracosanoyl-CoA) malonyl-CoA[erm] + H+[erm] + docosanoyl-CoA[erm] => carbon dioxide[erm] + coenzyme A[erm] + 3-oxotetracosanoyl-CoA[erm] YCR034W or YLR372W Biosynthesis of unsaturated fatty acids +r_2160 elongase III (3-oxohexacosanoyl-CoA) malonyl-CoA[erm] + H+[erm] + tetracosanoyl-CoA[erm] => carbon dioxide[erm] + coenzyme A[erm] + 3-oxohexacosanoyl-CoA[erm] YLR372W Biosynthesis of unsaturated fatty acids +r_2161 B-ketoacyl-CoA reductase ((S)-3-hydroxytetradecanoyl-CoA) H+[erm] + 3-oxotetradecanoyl-CoA[erm] + NADPH[erm] => NADP(+)[erm] + (S)-3-hydroxytetradecanoyl-CoA[erm] YBR159W Biosynthesis of unsaturated fatty acids +r_2162 B-ketoacyl-CoA reductase ((S)-3-hydroxypalmitoyl-CoA) H+[erm] + 3-oxopalmitoyl-CoA[erm] + NADPH[erm] => NADP(+)[erm] + (S)-3-hydroxypalmitoyl-CoA[erm] YBR159W Biosynthesis of unsaturated fatty acids +r_2163 B-ketoacyl-CoA reductase (3-hydroxyoctadecanoyl-CoA) H+[erm] + 3-oxooctadecanoyl-CoA[erm] + NADPH[erm] => NADP(+)[erm] + 3-hydroxyoctadecanoyl-CoA[erm] YBR159W Biosynthesis of unsaturated fatty acids +r_2164 B-ketoacyl-CoA reductase (3-hydroxyicosanoyl-CoA) H+[erm] + 3-oxoicosanoyl-CoA[erm] + NADPH[erm] => NADP(+)[erm] + 3-hydroxyicosanoyl-CoA[erm] YBR159W Biosynthesis of unsaturated fatty acids +r_2165 B-ketoacyl-CoA reductase (3-hydroxydocosanoyl-CoA) H+[erm] + 3-oxodocosanoyl-CoA[erm] + NADPH[erm] => NADP(+)[erm] + 3-hydroxydocosanoyl-CoA[erm] YBR159W Biosynthesis of unsaturated fatty acids +r_2166 B-ketoacyl-CoA reductase (3-hydroxytetracosanoyl-CoA) H+[erm] + 3-oxotetracosanoyl-CoA[erm] + NADPH[erm] => NADP(+)[erm] + 3-hydroxytetracosanoyl-CoA[erm] YBR159W Biosynthesis of unsaturated fatty acids +r_2167 B-ketoacyl-CoA reductase ((S)-3-hydroxyhexacosanoyl-CoA) H+[erm] + 3-oxohexacosanoyl-CoA[erm] + NADPH[erm] => NADP(+)[erm] + (S)-3-hydroxyhexacosanoyl-CoA[erm] YBR159W Biosynthesis of unsaturated fatty acids +r_2168 B-hydroxyacyl-CoA dehydratase (trans-tetradec-2-enoyl-CoA) (S)-3-hydroxytetradecanoyl-CoA[erm] <=> H2O[erm] + trans-tetradec-2-enoyl-CoA[erm] YJL097W Biosynthesis of unsaturated fatty acids +r_2169 B-hydroxyacyl-CoA dehydratase (trans-hexadec-2-enoyl-CoA) (S)-3-hydroxypalmitoyl-CoA[erm] <=> H2O[erm] + trans-hexadec-2-enoyl-CoA[erm] YJL097W Biosynthesis of unsaturated fatty acids +r_2170 B-hydroxyacyl-CoA dehydratase (trans-octadec-2-enoyl-CoA) 3-hydroxyoctadecanoyl-CoA[erm] <=> H2O[erm] + trans-octadec-2-enoyl-CoA[erm] YJL097W Biosynthesis of unsaturated fatty acids +r_2171 B-hydroxyacyl-CoA dehydratase (trans-icos-2-enoyl-CoA) 3-hydroxyicosanoyl-CoA[erm] <=> H2O[erm] + trans-icos-2-enoyl-CoA[erm] YJL097W Biosynthesis of unsaturated fatty acids +r_2172 B-hydroxyacyl-CoA dehydratase (trans-docos-2-enoyl-CoA) 3-hydroxydocosanoyl-CoA[erm] <=> H2O[erm] + trans-docos-2-enoyl-CoA[erm] YJL097W Biosynthesis of unsaturated fatty acids +r_2173 B-hydroxyacyl-CoA dehydratase (trans-tetracos-2-enoyl-CoA) 3-hydroxytetracosanoyl-CoA[erm] => H2O[erm] + trans-tetracos-2-enoyl-CoA[erm] YJL097W Biosynthesis of unsaturated fatty acids +r_2174 B-hydroxyacyl-CoA dehydratase (trans-hexacos-2-enoyl-CoA) (S)-3-hydroxyhexacosanoyl-CoA[erm] <=> H2O[erm] + trans-hexacos-2-enoyl-CoA[erm] YJL097W Biosynthesis of unsaturated fatty acids +r_2175 trans-2-enoyl-CoA reductase (n-C14:0CoA) H+[erm] + NADPH[erm] + trans-tetradec-2-enoyl-CoA[erm] => myristoyl-CoA[erm] + NADP(+)[erm] YDL015C Biosynthesis of unsaturated fatty acids +r_2176 trans-2-enoyl-CoA reductase (n-C16:0CoA) H+[erm] + NADPH[erm] + trans-hexadec-2-enoyl-CoA[erm] => palmitoyl-CoA[erm] + NADP(+)[erm] YDL015C Biosynthesis of unsaturated fatty acids +r_2177 trans-2-enoyl-CoA reductase (n-C18:0CoA) H+[erm] + NADPH[erm] + trans-octadec-2-enoyl-CoA[erm] => stearoyl-CoA[erm] + NADP(+)[erm] YDL015C Biosynthesis of unsaturated fatty acids +r_2178 trans-2-enoyl-CoA reductase (n-C20:0CoA) H+[erm] + NADPH[erm] + trans-icos-2-enoyl-CoA[erm] => icosanoyl-CoA[erm] + NADP(+)[erm] YDL015C Biosynthesis of unsaturated fatty acids +r_2179 trans-2-enoyl-CoA reductase (n-C22:0CoA) H+[erm] + NADPH[erm] + trans-docos-2-enoyl-CoA[erm] => docosanoyl-CoA[erm] + NADP(+)[erm] YDL015C Biosynthesis of unsaturated fatty acids +r_2180 trans-2-enoyl-CoA reductase (n-C24:0CoA) H+[erm] + NADPH[erm] + trans-tetracos-2-enoyl-CoA[erm] => tetracosanoyl-CoA[erm] + NADP(+)[erm] YDL015C Biosynthesis of unsaturated fatty acids +r_2181 trans-2-enoyl-CoA reductase (n-C26:0CoA) H+[erm] + NADPH[erm] + trans-hexacos-2-enoyl-CoA[erm] => NADP(+)[erm] + hexacosanoyl-CoA[erm] YDL015C Biosynthesis of unsaturated fatty acids +r_2182 palmitoyl-CoA desaturase (n-C16:0CoA -> n-C16:1CoA), ER membrane H+[erm] + palmitoyl-CoA[erm] + oxygen[erm] + NADH[erm] => 2 H2O[erm] + palmitoleoyl-CoA(4-)[erm] + NAD[erm] YGL055W Biosynthesis of unsaturated fatty acids +r_2183 stearoyl-CoA desaturase (n-C18:0CoA -> n-C18:1CoA), ER membrane H+[erm] + stearoyl-CoA[erm] + oxygen[erm] + NADH[erm] => 2 H2O[erm] + NAD[erm] + oleoyl-CoA[erm] YGL055W Biosynthesis of unsaturated fatty acids +r_2184 octanoate (n-C8:0) transport octanoate[e] <=> octanoate[c] Transport [c, e] +r_2185 decanoate (n-C10:0) transport decanoate[e] <=> decanoate[c] Transport [c, e] +r_2186 laurate (n-C12:0) transport laurate[e] <=> laurate[c] Transport [c, e] +r_2187 butyrate exchange butyrate[e] => Exchange reaction +r_2188 hexanoate exchange hexanoate[e] => Exchange reaction +r_2189 oleate exchange oleate[e] => Exchange reaction +r_2190 butyrate (n-C4:0) transport butyrate[e] <=> butyrate[c] YNL065W Transport [c, e] +r_2191 hexanoate (n-C6:0) transport hexanoate[e] <=> hexanoate[c] YNL065W Transport [c, e] +r_2192 octadecenoate (n-C18:1) transport oleate[e] <=> oleate[c] Transport [c, e] +r_2193 myristate exchange myristate[e] => Exchange reaction +r_2194 fatty-acid--CoA ligase (dodecanoate), ER membrane coenzyme A[erm] + ATP[erm] + laurate[erm] <=> lauroyl-CoA[erm] + AMP[erm] + diphosphate[erm] YOR317W Fatty acid biosynthesis +r_2195 fatty-acid--CoA ligase (tetradecanoate), ER membrane coenzyme A[erm] + ATP[erm] + myristate[erm] <=> myristoyl-CoA[erm] + AMP[erm] + diphosphate[erm] YMR246W or YOR317W Fatty acid biosynthesis +r_2196 fatty-acid--CoA ligase (hexadecanoate), ER membrane coenzyme A[erm] + ATP[erm] + palmitate[erm] <=> palmitoyl-CoA[erm] + AMP[erm] + diphosphate[erm] YMR246W or YOR317W Fatty acid biosynthesis +r_2197 fatty-acid--CoA ligase (hexadecenoate), ER membrane coenzyme A[erm] + ATP[erm] + palmitoleate[erm] <=> palmitoleoyl-CoA(4-)[erm] + AMP[erm] + diphosphate[erm] YMR246W or YOR317W Fatty acid biosynthesis +r_2198 fatty-acid--CoA ligase (octadecanoate), ER membrane coenzyme A[erm] + ATP[erm] + stearate[erm] <=> stearoyl-CoA[erm] + AMP[erm] + diphosphate[erm] YMR246W or YOR317W Fatty acid biosynthesis +r_2199 fatty-acid--CoA ligase (octadecenoate), ER membrane coenzyme A[erm] + ATP[erm] + oleate[erm] <=> oleoyl-CoA[erm] + AMP[erm] + diphosphate[erm] YMR246W or YOR317W Fatty acid biosynthesis +r_2200 fatty-acid--CoA ligase (dodecanoate), lipid particle coenzyme A[lp] + ATP[lp] + laurate[lp] <=> diphosphate[lp] + AMP[lp] + lauroyl-CoA[lp] YOR317W Fatty acid biosynthesis +r_2201 fatty-acid--CoA ligase (tetradecanoate), lipid particle coenzyme A[lp] + ATP[lp] + myristate[lp] <=> diphosphate[lp] + AMP[lp] + myristoyl-CoA[lp] YMR246W or YOR317W Fatty acid biosynthesis +r_2202 fatty-acid--CoA ligase (hexadecanoate), lipid particle coenzyme A[lp] + ATP[lp] + palmitate[lp] <=> diphosphate[lp] + AMP[lp] + palmitoyl-CoA[lp] YMR246W or YOR317W Fatty acid biosynthesis +r_2203 fatty-acid--CoA ligase (hexadecenoate), lipid particle coenzyme A[lp] + ATP[lp] + palmitoleate[lp] <=> diphosphate[lp] + AMP[lp] + palmitoleoyl-CoA(4-)[lp] YMR246W or YOR317W Fatty acid biosynthesis +r_2204 fatty-acid--CoA ligase (octadecanoate), lipid particle coenzyme A[lp] + ATP[lp] + stearate[lp] <=> diphosphate[lp] + AMP[lp] + stearoyl-CoA[lp] YMR246W or YOR317W Fatty acid biosynthesis +r_2205 fatty-acid--CoA ligase (octadecenoate), lipid particle coenzyme A[lp] + ATP[lp] + oleate[lp] <=> diphosphate[lp] + AMP[lp] + oleoyl-CoA[lp] YMR246W or YOR317W Fatty acid biosynthesis +r_2206 fatty-acid--CoA ligase (hexadecenoate), peroxisome ATP[p] + coenzyme A[p] + palmitoleate[p] <=> AMP[p] + diphosphate[p] + palmitoleoyl-CoA(4-)[p] YER015W Fatty acid biosynthesis +r_2207 fatty-acid--CoA ligase (octadecanoate), peroxisome ATP[p] + coenzyme A[p] + stearate[p] <=> AMP[p] + diphosphate[p] + stearoyl-CoA[p] YER015W Fatty acid biosynthesis +r_2208 fatty-acid--CoA ligase (octadecenoate), peroxisome ATP[p] + coenzyme A[p] + oleate[p] <=> AMP[p] + diphosphate[p] + oleoyl-CoA[p] YER015W Fatty acid biosynthesis +r_2209 fatty-acid--CoA ligase (arachidate), cell envelope ATP[ce] + coenzyme A[ce] + arachidate[ce] <=> AMP[ce] + diphosphate[ce] + icosanoyl-CoA[ce] YIL009W Fatty acid biosynthesis +r_2210 fatty-acid--CoA ligase (behenate), cell envelope ATP[ce] + coenzyme A[ce] + behenate[ce] <=> AMP[ce] + diphosphate[ce] + docosanoyl-CoA[ce] YIL009W Fatty acid biosynthesis +r_2211 fatty-acid--CoA ligase (lignoceric acid), cell envelope ATP[ce] + coenzyme A[ce] + lignoceric acid[ce] <=> AMP[ce] + diphosphate[ce] + tetracosanoyl-CoA[ce] YIL009W Fatty acid biosynthesis +r_2212 fatty-acid--CoA ligase (cerotic acid), cell envelope ATP[ce] + coenzyme A[ce] + cerotic acid[ce] <=> AMP[ce] + diphosphate[ce] + hexacosanoyl-CoA[ce] YIL009W Fatty acid biosynthesis +r_2213 fatty-acid--CoA ligase (behenate), ER membrane coenzyme A[erm] + ATP[erm] + behenate[erm] <=> docosanoyl-CoA[erm] + AMP[erm] + diphosphate[erm] YBR041W Fatty acid biosynthesis +r_2214 fatty-acid--CoA ligase (lignoceric acid), ER membrane coenzyme A[erm] + ATP[erm] + lignoceric acid[erm] <=> tetracosanoyl-CoA[erm] + AMP[erm] + diphosphate[erm] YBR041W Fatty acid biosynthesis +r_2215 fatty-acid--CoA ligase (cerotic acid), ER membrane coenzyme A[erm] + ATP[erm] + cerotic acid[erm] <=> hexacosanoyl-CoA[erm] + AMP[erm] + diphosphate[erm] YBR041W Fatty acid biosynthesis +r_2216 fatty-acid--CoA ligase (behenate), lipid particle coenzyme A[lp] + ATP[lp] + behenate[lp] <=> diphosphate[lp] + AMP[lp] + docosanoyl-CoA[lp] YBR041W Fatty acid biosynthesis +r_2217 fatty-acid--CoA ligase (lignoceric acid), lipid particle coenzyme A[lp] + ATP[lp] + lignoceric acid[lp] <=> diphosphate[lp] + AMP[lp] + tetracosanoyl-CoA[lp] YBR041W Fatty acid biosynthesis +r_2218 fatty-acid--CoA ligase (cerotic acid), lipid particle coenzyme A[lp] + ATP[lp] + cerotic acid[lp] <=> diphosphate[lp] + AMP[lp] + hexacosanoyl-CoA[lp] YBR041W Fatty acid biosynthesis +r_2219 fatty acyl-CoA transport via ABC system (C12:0) ATP[c] + H2O[c] + lauroyl-CoA[c] => ADP[c] + H+[c] + lauroyl-CoA[p] + phosphate[c] YKL188C and YPL147W Transport [c, p] +r_2220 fatty acyl-CoA transport via ABC system (C14:0) ATP[c] + H2O[c] + myristoyl-CoA[c] => ADP[c] + H+[c] + myristoyl-CoA[p] + phosphate[c] YKL188C and YPL147W Transport [c, p] +r_2221 fatty acyl-CoA transport via ABC system (C16:0) ATP[c] + H2O[c] + palmitoyl-CoA[c] => ADP[c] + H+[c] + palmitoyl-CoA[p] + phosphate[c] YKL188C and YPL147W Transport [c, p] +r_2222 fatty acyl-CoA transport via ABC system (C16:1) ATP[c] + H2O[c] + palmitoleoyl-CoA(4-)[c] => ADP[c] + H+[c] + phosphate[c] + palmitoleoyl-CoA(4-)[p] YKL188C and YPL147W Transport [c, p] +r_2223 fatty acyl-CoA transport via ABC system (C18:0) ATP[c] + H2O[c] + stearoyl-CoA[c] => ADP[c] + H+[c] + phosphate[c] + stearoyl-CoA[p] YKL188C and YPL147W Transport [c, p] +r_2224 fatty acyl-CoA transport via ABC system (C18:1) ATP[c] + H2O[c] + oleoyl-CoA[c] => ADP[c] + H+[c] + oleoyl-CoA[p] + phosphate[c] YKL188C and YPL147W Transport [c, p] +r_2225 fatty acyl-CoA transport via ABC system (C20:0) ATP[c] + H2O[c] + icosanoyl-CoA[c] => ADP[c] + H+[c] + phosphate[c] + icosanoyl-CoA[p] YKL188C and YPL147W Transport [c, p] +r_2226 fatty acyl-CoA transport via ABC system (C22:0) ATP[c] + H2O[c] + docosanoyl-CoA[c] => ADP[c] + H+[c] + phosphate[c] + docosanoyl-CoA[p] YKL188C and YPL147W Transport [c, p] +r_2227 fatty acyl-CoA transport via ABC system (C24:0) ATP[c] + H2O[c] + tetracosanoyl-CoA[c] => ADP[c] + H+[c] + phosphate[c] + tetracosanoyl-CoA[p] YKL188C and YPL147W Transport [c, p] +r_2228 fatty acyl-CoA transport via ABC system (C26:0) ATP[c] + H2O[c] + hexacosanoyl-CoA[c] => ADP[c] + H+[c] + hexacosanoyl-CoA[p] + phosphate[c] YKL188C and YPL147W Transport [c, p] +r_2229 butyrate (n-C4:0) transport, cytoplasm-peroxisome butyrate[c] <=> butyrate[p] Transport [c, p] +r_2230 hexanoate (n-C6:0) transport, cytoplasm-peroxisome hexanoate[c] <=> hexanoate[p] Transport [c, p] +r_2231 octadecenoate (n-C18:1) transport, cytoplasm-peroxisome oleate[c] <=> oleate[p] YKL188C and YPL147W Transport [c, p] +r_2232 peroxisomal acyl-CoA thioesterase (4:0) H2O[p] + butanoyl-CoA[p] => coenzyme A[p] + 5 H+[p] + butyrate[p] YJR019C Biosynthesis of unsaturated fatty acids +r_2233 peroxisomal acyl-CoA thioesterase (6:0) H2O[p] + hexanoyl-CoA[p] => coenzyme A[p] + 5 H+[p] + hexanoate[p] YJR019C Biosynthesis of unsaturated fatty acids +r_2234 peroxisomal acyl-CoA thioesterase (16:1) H2O[p] + palmitoleoyl-CoA(4-)[p] => coenzyme A[p] + H+[p] + palmitoleate[p] YJR019C Biosynthesis of unsaturated fatty acids +r_2235 peroxisomal acyl-CoA thioesterase (18:1) H2O[p] + oleoyl-CoA[p] => coenzyme A[p] + H+[p] + oleate[p] YJR019C Biosynthesis of unsaturated fatty acids +r_2236 acyl-CoA oxidase (butanoyl-CoA) oxygen[p] + butanoyl-CoA[p] => hydrogen peroxide[p] + but-2-enoyl-CoA[p] YGL205W Fatty acid degradation +r_2237 acyl-CoA oxidase (hexanoyl-CoA) oxygen[p] + hexanoyl-CoA[p] => hydrogen peroxide[p] + trans-hex-2-enoyl-CoA[p] YGL205W Fatty acid degradation +r_2238 acyl-CoA oxidase (octanoyl-CoA) octanoyl-CoA[p] + oxygen[p] => hydrogen peroxide[p] + trans-oct-2-enoyl-CoA[p] YGL205W Fatty acid degradation +r_2239 acyl-CoA oxidase (icosanoyl-CoA) oxygen[p] + icosanoyl-CoA[p] => hydrogen peroxide[p] + trans-icos-2-enoyl-CoA[p] YGL205W Fatty acid degradation +r_2240 acyl-CoA oxidase (docosanoyl-CoA) oxygen[p] + docosanoyl-CoA[p] => hydrogen peroxide[p] + trans-docos-2-enoyl-CoA[p] YGL205W Fatty acid degradation +r_2241 acyl-CoA oxidase (tetracosanoyl-CoA) oxygen[p] + tetracosanoyl-CoA[p] => hydrogen peroxide[p] + trans-tetracos-2-enoyl-CoA[p] YGL205W Fatty acid degradation +r_2242 acyl-CoA oxidase (palmitoleoyl-CoA) 4 H+[p] + oxygen[p] + palmitoleoyl-CoA(4-)[p] => hydrogen peroxide[p] + trans-2,cis-9-hexadecadienoyl-CoA[p] YGL205W Fatty acid degradation +r_2243 acyl-CoA oxidase (cis-tetradec-7-enoyl-CoA) oxygen[p] + cis-tetradec-7-enoyl-CoA[p] => hydrogen peroxide[p] + trans-2,cis-7-tetradecadienoyl-CoA[p] YGL205W Fatty acid degradation +r_2244 acyl-CoA oxidase (cis-dodec-5-enoyl-CoA) oxygen[p] + cis-dodec-5-enoyl-CoA[p] => hydrogen peroxide[p] + trans-2,cis-5-dodecadienoyl-CoA[p] YGL205W Fatty acid degradation +r_2245 acyl-CoA oxidase (oleoyl-CoA) oleoyl-CoA[p] + oxygen[p] => hydrogen peroxide[p] + trans-2,cis-9-octadecadienoyl-CoA[p] YGL205W Fatty acid degradation +r_2246 acyl-CoA oxidase (cis-hexadec-7-enoyl-CoA) oxygen[p] + cis-hexadec-7-enoyl-CoA[p] => hydrogen peroxide[p] + trans-2,cis-7-hexadecadienoyl-CoA[p] YGL205W Fatty acid degradation +r_2247 acyl-CoA oxidase (cis-tetradec-5-enoyl-CoA) oxygen[p] + cis-tetradec-5-enoyl-CoA[p] => hydrogen peroxide[p] + trans-2,cis-5-tetradecadienoyl-CoA[p] YGL205W Fatty acid degradation +r_2248 2-enoyl-CoA hydratase (3-hydroxydecanoyl-CoA) H2O[p] + trans-dec-2-enoyl-CoA[p] => (R)-3-hydroxydecanoyl-CoA[p] YKR009C Fatty acid degradation +r_2249 2-enoyl-CoA hydratase (3-hydroxydodecanoyl-CoA) H2O[p] + trans-dodec-2-enoyl-CoA[p] => (R)-3-hydroxylauroyl-CoA[p] YKR009C Fatty acid degradation +r_2250 2-enoyl-CoA hydratase (3-hydroxytetradecanoyl-CoA) H2O[p] + trans-tetradec-2-enoyl-CoA[p] => (S)-3-hydroxytetradecanoyl-CoA[p] YKR009C Fatty acid degradation +r_2251 2-enoyl-CoA hydratase (3-hydroxyhexadecanoyl-CoA) H2O[p] + hexadec-2-enoyl-CoA[p] => (S)-3-hydroxypalmitoyl-CoA[p] YKR009C Fatty acid degradation +r_2252 2-enoyl-CoA hydratase (3-hydroxyoctadecanoyl-CoA) H2O[p] + trans-octadec-2-enoyl-CoA[p] => 3-hydroxyoctadecanoyl-CoA[p] YKR009C Fatty acid degradation +r_2253 2-enoyl-CoA hydratase (3-hydroxyhexacosanoyl-CoA) H2O[p] + trans-hexacos-2-enoyl-CoA[p] => (S)-3-hydroxyhexacosanoyl-CoA[p] YKR009C Fatty acid degradation +r_2254 2-enoyl-CoA hydratase (3-hydroxybutanoyl-CoA) H2O[p] + but-2-enoyl-CoA[p] => 4 H+[p] + (R)-3-hydroxybutanoyl-CoA[p] YKR009C Fatty acid degradation +r_2255 2-enoyl-CoA hydratase (3-hydroxyhexanoyl-CoA) H2O[p] + trans-hex-2-enoyl-CoA[p] => (R)-3-hydroxyhexanoyl-CoA[p] YKR009C Fatty acid degradation +r_2256 2-enoyl-CoA hydratase (3-hydroxyoctanoyl-CoA) 4 H+[p] + H2O[p] + trans-oct-2-enoyl-CoA[p] => (R)-3-hydroxyoctanoyl-CoA[p] YKR009C Fatty acid degradation +r_2257 2-enoyl-CoA hydratase (3-hydroxyicosanoyl-CoA) H2O[p] + trans-icos-2-enoyl-CoA[p] => (R)-3-hydroxyicosanoyl-CoA[p] YKR009C Fatty acid degradation +r_2258 2-enoyl-CoA hydratase (3-hydroxydocosanoyl-CoA) H2O[p] + trans-docos-2-enoyl-CoA[p] => (R)-3-hydroxydocosanoyl-CoA[p] YKR009C Fatty acid degradation +r_2259 2-enoyl-CoA hydratase (3-hydroxytetracosanoyl-CoA) H2O[p] + trans-tetracos-2-enoyl-CoA[p] => (R)-3-hydroxytetracosanoyl-CoA[p] YKR009C Fatty acid degradation +r_2260 2-enoyl-CoA hydratase (3-hydroxy-cis-hexadec-9-enoyl-CoA) H2O[p] + trans-2,cis-9-hexadecadienoyl-CoA[p] => (R)-3-hydroxy-cis-hexadec-9-enoyl-CoA[p] YKR009C Fatty acid degradation +r_2261 2-enoyl-CoA hydratase (3-hydroxy-cis-tetradec-7-enoyl-CoA) H2O[p] + trans-2,cis-7-tetradecadienoyl-CoA[p] => (R)-3-hydroxy-cis-tetradec-7-enoyl-CoA[p] YKR009C Fatty acid degradation +r_2262 2-enoyl-CoA hydratase (3-hydroxy-cis-dodec-5-enoyl-CoA) H2O[p] + trans-2,cis-5-dodecadienoyl-CoA[p] => (R)-3-hydroxy-cis-dodec-5-enoyl-CoA[p] YKR009C Fatty acid degradation +r_2263 2-enoyl-CoA hydratase (3-hydroxy-cis-octadec-9-enoyl-CoA) 4 H+[p] + H2O[p] + trans-2,cis-9-octadecadienoyl-CoA[p] => (R)-3-hydroxy-cis-octadec-9-enoyl-CoA[p] YKR009C Fatty acid degradation +r_2264 2-enoyl-CoA hydratase (3-hydroxy-cis-hexadec-7-enoyl-CoA) H2O[p] + trans-2,cis-7-hexadecadienoyl-CoA[p] => (R)-3-hydroxy-cis-hexadec-7-enoyl-CoA[p] YKR009C Fatty acid degradation +r_2265 2-enoyl-CoA hydratase (3-hydroxy-cis-tetradec-5-enoyl-CoA) H2O[p] + trans-2,cis-5-tetradecadienoyl-CoA[p] => (R)-3-hydroxy-cis-tetradec-5-enoyl-CoA[p] YKR009C Fatty acid degradation +r_2266 3-hydroxyacyl-CoA dehydrogenase (3-oxodecanoyl-CoA) (R)-3-hydroxydecanoyl-CoA[p] + NAD[p] => 3-oxodecanoyl-CoA[p] + H+[p] + NADH[p] YKR009C Fatty acid degradation +r_2267 3-hydroxyacyl-CoA dehydrogenase (3-oxododecanoyl-CoA) (R)-3-hydroxylauroyl-CoA[p] + NAD[p] => 3-oxolauroyl-CoA[p] + H+[p] + NADH[p] YKR009C Fatty acid degradation +r_2268 3-hydroxyacyl-CoA dehydrogenase (3-oxohexadecanoyl-CoA) (S)-3-hydroxypalmitoyl-CoA[p] + NAD[p] => 3-oxopalmitoyl-CoA[p] + H+[p] + NADH[p] YKR009C Fatty acid degradation +r_2269 3-hydroxyacyl-CoA dehydrogenase (3-oxooctadecanoyl-CoA) 3-hydroxyoctadecanoyl-CoA[p] + NAD[p] => 3-oxooctadecanoyl-CoA[p] + H+[p] + NADH[p] YKR009C Fatty acid degradation +r_2270 3-hydroxyacyl-CoA dehydrogenase (3-oxohexacosanoyl-CoA) (S)-3-hydroxyhexacosanoyl-CoA[p] + NAD[p] => 3-oxohexacosanoyl-CoA[p] + H+[p] + NADH[p] YKR009C Fatty acid degradation +r_2271 3-hydroxyacyl-CoA dehydrogenase (3-oxobutanoyl-CoA) NAD[p] + (R)-3-hydroxybutanoyl-CoA[p] => H+[p] + NADH[p] + acetoacetyl-CoA[p] YKR009C Fatty acid degradation +r_2272 3-hydroxyacyl-CoA dehydrogenase (3-oxohexanoyl-CoA) NAD[p] + (R)-3-hydroxyhexanoyl-CoA[p] => H+[p] + NADH[p] + 3-oxohexanoyl-CoA[p] YKR009C Fatty acid degradation +r_2273 3-hydroxyacyl-CoA dehydrogenase (3-oxooctanoyl-CoA) NAD[p] + (R)-3-hydroxyoctanoyl-CoA[p] => H+[p] + NADH[p] + 3-oxooctanoyl-CoA[p] YKR009C Fatty acid degradation +r_2274 3-hydroxyacyl-CoA dehydrogenase (3-oxoicosanoyl-CoA) NAD[p] + (R)-3-hydroxyicosanoyl-CoA[p] => H+[p] + NADH[p] + 3-oxoicosanoyl-CoA[p] YKR009C Fatty acid degradation +r_2275 3-hydroxyacyl-CoA dehydrogenase (3-oxodocosanoyl-CoA) NAD[p] + (R)-3-hydroxydocosanoyl-CoA[p] => H+[p] + NADH[p] + 3-oxodocosanoyl-CoA[p] YKR009C Fatty acid degradation +r_2276 3-hydroxyacyl-CoA dehydrogenase (3-oxotetracosanoyl-CoA) NAD[p] + (R)-3-hydroxytetracosanoyl-CoA[p] => H+[p] + NADH[p] + 3-oxotetracosanoyl-CoA[p] YKR009C Fatty acid degradation +r_2277 3-hydroxyacyl-CoA dehydrogenase (3-oxo-cis-hexadec-9-enoyl-CoA) NAD[p] + (R)-3-hydroxy-cis-hexadec-9-enoyl-CoA[p] => H+[p] + NADH[p] + 3-oxo-cis-hexadec-9-enoyl-CoA[p] YKR009C Fatty acid degradation +r_2278 3-hydroxyacyl-CoA dehydrogenase (3-oxo-cis-tetradec-7-enoyl-CoA) NAD[p] + (R)-3-hydroxy-cis-tetradec-7-enoyl-CoA[p] => H+[p] + NADH[p] + 3-oxo-cis-tetradec-7-enoyl-CoA[p] YKR009C Fatty acid degradation +r_2279 3-hydroxyacyl-CoA dehydrogenase (3-oxo-cis-dodec-5-enoyl-CoA) NAD[p] + (R)-3-hydroxy-cis-dodec-5-enoyl-CoA[p] => H+[p] + NADH[p] + 3-oxo-cis-dodec-5-enoyl-CoA[p] YKR009C Fatty acid degradation +r_2280 3-hydroxyacyl-CoA dehydrogenase (3-oxo-cis-octadec-9-enoyl-CoA) NAD[p] + (R)-3-hydroxy-cis-octadec-9-enoyl-CoA[p] => H+[p] + NADH[p] + 3-oxo-cis-octadec-9-enoyl-CoA[p] YKR009C Fatty acid degradation +r_2281 3-hydroxyacyl-CoA dehydrogenase (3-oxo-cis-hexadec-7-enoyl-CoA) NAD[p] + (R)-3-hydroxy-cis-hexadec-7-enoyl-CoA[p] => H+[p] + NADH[p] + 3-oxo-cis-hexadec-7-enoyl-CoA[p] YKR009C Fatty acid degradation +r_2282 3-hydroxyacyl-CoA dehydrogenase (3-oxo-cis-tetradec-5-enoyl-CoA) NAD[p] + (R)-3-hydroxy-cis-tetradec-5-enoyl-CoA[p] => H+[p] + NADH[p] + 3-oxo-cis-tetradec-5-enoyl-CoA[p] YKR009C Fatty acid degradation +r_2283 acetyl-CoA C-acyltransferase (acetyl-CoA) coenzyme A[p] + acetoacetyl-CoA[p] => 2 acetyl-CoA[p] YIL160C Fatty acid degradation +r_2284 acetyl-CoA C-acyltransferase (butanoyl-CoA) coenzyme A[p] + 3-oxohexanoyl-CoA[p] => acetyl-CoA[p] + butanoyl-CoA[p] YIL160C Fatty acid degradation +r_2285 acetyl-CoA C-acyltransferase (hexanoyl-CoA) coenzyme A[p] + 3-oxooctanoyl-CoA[p] => acetyl-CoA[p] + hexanoyl-CoA[p] YIL160C Fatty acid degradation +r_2286 acetyl-CoA C-acyltransferase (stearoyl-CoA) coenzyme A[p] + 3-oxoicosanoyl-CoA[p] => acetyl-CoA[p] + stearoyl-CoA[p] YIL160C Fatty acid degradation +r_2287 acetyl-CoA C-acyltransferase (icosanoyl-CoA) coenzyme A[p] + 3-oxodocosanoyl-CoA[p] => acetyl-CoA[p] + icosanoyl-CoA[p] YIL160C Fatty acid degradation +r_2288 acetyl-CoA C-acyltransferase (docosanoyl-CoA) coenzyme A[p] + 3-oxotetracosanoyl-CoA[p] => acetyl-CoA[p] + docosanoyl-CoA[p] YIL160C Fatty acid degradation +r_2289 acetyl-CoA C-acyltransferase (cis-tetradec-7-enoyl-CoA) coenzyme A[p] + 3-oxo-cis-hexadec-9-enoyl-CoA[p] => acetyl-CoA[p] + cis-tetradec-7-enoyl-CoA[p] YIL160C Fatty acid degradation +r_2290 acetyl-CoA C-acyltransferase (cis-dodec-5-enoyl-CoA) coenzyme A[p] + 3-oxo-cis-tetradec-7-enoyl-CoA[p] => acetyl-CoA[p] + cis-dodec-5-enoyl-CoA[p] YIL160C Fatty acid degradation +r_2291 acetyl-CoA C-acyltransferase (cis-dec-3-enoyl-CoA) coenzyme A[p] + 3-oxo-cis-dodec-5-enoyl-CoA[p] => acetyl-CoA[p] + cis-dec-3-enoyl-CoA[p] YIL160C Fatty acid degradation +r_2292 acetyl-CoA C-acyltransferase (cis-hexadec-7-enoyl-CoA) coenzyme A[p] + 3-oxo-cis-octadec-9-enoyl-CoA[p] => acetyl-CoA[p] + cis-hexadec-7-enoyl-CoA[p] YIL160C Fatty acid degradation +r_2293 acetyl-CoA C-acyltransferase (cis-tetradec-5-enoyl-CoA) coenzyme A[p] + 3-oxo-cis-hexadec-7-enoyl-CoA[p] => acetyl-CoA[p] + cis-tetradec-5-enoyl-CoA[p] YIL160C Fatty acid degradation +r_2294 acetyl-CoA C-acyltransferase (cis-dodec-3-enoyl-CoA) coenzyme A[p] + 3-oxo-cis-tetradec-5-enoyl-CoA[p] => acetyl-CoA[p] + cis-dodec-3-enoyl-CoA[p] YIL160C Fatty acid degradation +r_2295 delta3,delta2-enoyl-CoA isomerase (cis-dec-3-enoyl-CoA) cis-dec-3-enoyl-CoA[p] => 4 H+[p] + trans-dec-2-enoyl-CoA[p] YLR284C Fatty acid degradation +r_2296 delta3,delta2-enoyl-CoA isomerase (trans-2,cis-5-dodecadienoyl-CoA) trans-2,cis-5-dodecadienoyl-CoA[p] => trans-3,cis-5-dodecadienoyl-CoA[p] YLR284C Fatty acid degradation +r_2297 delta3,delta2-enoyl-CoA isomerase (trans-dodec-3-enoyl-CoA) trans-dodec-3-enoyl-CoA[p] => 4 H+[p] + trans-dodec-2-enoyl-CoA[p] YLR284C Fatty acid degradation +r_2298 delta3,delta2-enoyl-CoA isomerase (cis-dodec-3-enoyl-CoA) cis-dodec-3-enoyl-CoA[p] => 4 H+[p] + trans-dodec-2-enoyl-CoA[p] YLR284C Fatty acid degradation +r_2299 delta3,delta2-enoyl-CoA isomerase (trans-2,cis-5-tetradecadienoyl-CoA) trans-2,cis-5-tetradecadienoyl-CoA[p] => trans-3,cis-5-tetradecadienoyl-CoA[p] YLR284C Fatty acid degradation +r_2300 delta3,delta2-enoyl-CoA isomerase (trans-tetradec-3-enoyl-CoA) trans-tetradec-3-enoyl-CoA[p] => 4 H+[p] + trans-tetradec-2-enoyl-CoA[p] YLR284C Fatty acid degradation +r_2301 delta(3,5)-delta(2,4)-dienoyl-CoA isomerase (trans-3,cis-5-dodecadienoyl-CoA) trans-3,cis-5-dodecadienoyl-CoA[p] => trans-2,trans-4-dodecadienoyl-CoA[p] YOR180C Fatty acid degradation +r_2302 delta(3,5)-delta(2,4)-dienoyl-CoA isomerase (trans-3,cis-5-tetradecadienoyl-CoA) trans-3,cis-5-tetradecadienoyl-CoA[p] => trans-2,trans-4-tetradecadienoyl-CoA[p] YOR180C Fatty acid degradation +r_2303 2,4-dienoyl-CoA reductase (trans-2,trans-4-dodecadienoyl-CoA) H+[p] + NADPH[p] + trans-2,trans-4-dodecadienoyl-CoA[p] => NADP(+)[p] + trans-dodec-3-enoyl-CoA[p] YNL202W Ascospore biosynthesis https://www.yeastgenome.org/locus/S000005146 +r_2304 2,4-dienoyl-CoA reductase (trans-2,trans-4-tetradecadienoyl-CoA) H+[p] + NADPH[p] + trans-2,trans-4-tetradecadienoyl-CoA[p] => NADP(+)[p] + trans-tetradec-3-enoyl-CoA[p] YNL202W Ascospore biosynthesis https://www.yeastgenome.org/locus/S000005146 +r_2305 cis-aconitate(3-) to isocitrate cis-aconitate[c] + H2O[c] <=> isocitrate[c] YLR304C Citrate cycle (TCA cycle) +r_2308 glycerol-3-phosphate acyltransferase (16:0), ER membrane 2 H+[erm] + palmitoyl-CoA[erm] + glycerol 3-phosphate[erm] => coenzyme A[erm] + 1-acyl-sn-glycerol 3-phosphate (16:0)[erm] YBL011W or YKR067W Glycerolipid metabolism +r_2309 glycerol-3-phosphate acyltransferase (16:1), ER membrane 2 H+[erm] + palmitoleoyl-CoA(4-)[erm] + glycerol 3-phosphate[erm] => coenzyme A[erm] + 1-acyl-sn-glycerol 3-phosphate (16:1)[erm] YBL011W or YKR067W Glycerolipid metabolism +r_2310 glycerol-3-phosphate acyltransferase (18:0), ER membrane 2 H+[erm] + stearoyl-CoA[erm] + glycerol 3-phosphate[erm] => coenzyme A[erm] + 1-acyl-sn-glycerol 3-phosphate (18:0)[erm] YKR067W Glycerolipid metabolism +r_2311 glycerol-3-phosphate acyltransferase (18:1), ER membrane 2 H+[erm] + oleoyl-CoA[erm] + glycerol 3-phosphate[erm] => coenzyme A[erm] + 1-acyl-sn-glycerol 3-phosphate (18:1)[erm] YKR067W Glycerolipid metabolism +r_2312 dihydroxyacetone phosphate acyltransferase (16:0), ER membrane 2 H+[erm] + palmitoyl-CoA[erm] + dihydroxyacetone phosphate[erm] => coenzyme A[erm] + acylglycerone phosphate (16:0)[erm] YBL011W or YKR067W Glycerolipid metabolism +r_2313 dihydroxyacetone phosphate acyltransferase (16:1), ER membrane 2 H+[erm] + palmitoleoyl-CoA(4-)[erm] + dihydroxyacetone phosphate[erm] => coenzyme A[erm] + acylglycerone phosphate (16:1)[erm] YBL011W or YKR067W Glycerolipid metabolism +r_2314 dihydroxyacetone phosphate acyltransferase (18:0), ER membrane 2 H+[erm] + stearoyl-CoA[erm] + dihydroxyacetone phosphate[erm] => coenzyme A[erm] + acylglycerone phosphate (18:0)[erm] YKR067W Glycerolipid metabolism +r_2315 dihydroxyacetone phosphate acyltransferase (18:1), ER membrane 2 H+[erm] + oleoyl-CoA[erm] + dihydroxyacetone phosphate[erm] => coenzyme A[erm] + acylglycerone phosphate (18:1)[erm] YKR067W Glycerolipid metabolism +r_2316 glycerol-3-phosphate acyltransferase (16:0), lipid particle glycerol 3-phosphate[lp] + 2 H+[erm] + palmitoyl-CoA[lp] => coenzyme A[lp] + 1-acyl-sn-glycerol 3-phosphate (16:0)[lp] YKR067W Glycerolipid metabolism +r_2317 glycerol-3-phosphate acyltransferase (16:1), lipid particle glycerol 3-phosphate[lp] + 2 H+[erm] + palmitoleoyl-CoA(4-)[lp] => coenzyme A[lp] + 1-acyl-sn-glycerol 3-phosphate (16:1)[lp] YKR067W Glycerolipid metabolism +r_2318 glycerol-3-phosphate acyltransferase (18:0), lipid particle glycerol 3-phosphate[lp] + 2 H+[erm] + stearoyl-CoA[lp] => coenzyme A[lp] + 1-acyl-sn-glycerol 3-phosphate (18:0)[lp] YKR067W Glycerolipid metabolism +r_2319 glycerol-3-phosphate acyltransferase (18:1), lipid particle glycerol 3-phosphate[lp] + 2 H+[erm] + oleoyl-CoA[lp] => coenzyme A[lp] + 1-acyl-sn-glycerol 3-phosphate (18:1)[lp] YKR067W Glycerolipid metabolism +r_2320 dihydroxyacetone phosphate acyltransferase (16:0), lipid particle dihydroxyacetone phosphate[lp] + 2 H+[lp] + palmitoyl-CoA[lp] => coenzyme A[lp] + acylglycerone phosphate (16:0)[lp] YKR067W Glycerolipid metabolism +r_2321 dihydroxyacetone phosphate acyltransferase (16:1), lipid particle dihydroxyacetone phosphate[lp] + 2 H+[lp] + palmitoleoyl-CoA(4-)[lp] => coenzyme A[lp] + acylglycerone phosphate (16:1)[lp] YKR067W Glycerolipid metabolism +r_2322 dihydroxyacetone phosphate acyltransferase (18:0), lipid particle dihydroxyacetone phosphate[lp] + 2 H+[lp] + stearoyl-CoA[lp] => coenzyme A[lp] + acylglycerone phosphate (18:0)[lp] YKR067W Glycerolipid metabolism +r_2323 dihydroxyacetone phosphate acyltransferase (18:1), lipid particle dihydroxyacetone phosphate[lp] + 2 H+[lp] + oleoyl-CoA[lp] => coenzyme A[lp] + acylglycerone phosphate (18:1)[lp] YKR067W Glycerolipid metabolism +r_2324 acyl dhap reductase (16:0), ER membrane H+[erm] + NADPH[erm] + acylglycerone phosphate (16:0)[erm] => NADP(+)[erm] + 1-acyl-sn-glycerol 3-phosphate (16:0)[erm] YIL124W Glycerophospholipid metabolism +r_2325 acyl dhap reductase (16:1), ER membrane H+[erm] + NADPH[erm] + acylglycerone phosphate (16:1)[erm] => NADP(+)[erm] + 1-acyl-sn-glycerol 3-phosphate (16:1)[erm] YIL124W Glycerophospholipid metabolism +r_2326 acyl dhap reductase (18:0), ER membrane H+[erm] + NADPH[erm] + acylglycerone phosphate (18:0)[erm] => NADP(+)[erm] + 1-acyl-sn-glycerol 3-phosphate (18:0)[erm] YIL124W Glycerophospholipid metabolism +r_2327 acyl dhap reductase (18:1), ER membrane H+[erm] + NADPH[erm] + acylglycerone phosphate (18:1)[erm] => NADP(+)[erm] + 1-acyl-sn-glycerol 3-phosphate (18:1)[erm] YIL124W Glycerophospholipid metabolism +r_2328 acyl dhap reductase (16:0), lipid particle H+[lp] + acylglycerone phosphate (16:0)[lp] + NADPH[lp] => 1-acyl-sn-glycerol 3-phosphate (16:0)[lp] + NADP(+)[lp] YIL124W Glycerophospholipid metabolism +r_2329 acyl dhap reductase (16:1), lipid particle H+[lp] + acylglycerone phosphate (16:1)[lp] + NADPH[lp] => 1-acyl-sn-glycerol 3-phosphate (16:1)[lp] + NADP(+)[lp] YIL124W Glycerophospholipid metabolism +r_2330 acyl dhap reductase (18:0), lipid particle H+[lp] + acylglycerone phosphate (18:0)[lp] + NADPH[lp] => 1-acyl-sn-glycerol 3-phosphate (18:0)[lp] + NADP(+)[lp] YIL124W Glycerophospholipid metabolism +r_2331 acyl dhap reductase (18:1), lipid particle H+[lp] + acylglycerone phosphate (18:1)[lp] + NADPH[lp] => 1-acyl-sn-glycerol 3-phosphate (18:1)[lp] + NADP(+)[lp] YIL124W Glycerophospholipid metabolism +r_2332 1-acyl-sn-glycerol-3-phosphate acyltransferase (1-16:0, 2-16:1), ER membrane palmitoleoyl-CoA(4-)[erm] + 1-acyl-sn-glycerol 3-phosphate (16:0)[erm] => coenzyme A[erm] + phosphatidate (1-16:0, 2-16:1)[erm] YOR175C Glycerolipid metabolism +r_2333 1-acyl-sn-glycerol-3-phosphate acyltransferase (1-16:0, 2-18:1), ER membrane oleoyl-CoA[erm] + 1-acyl-sn-glycerol 3-phosphate (16:0)[erm] => coenzyme A[erm] + phosphatidate (1-16:0, 2-18:1)[erm] YDL052C or YOR175C Glycerolipid metabolism +r_2334 1-acyl-sn-glycerol-3-phosphate acyltransferase (1-16:1, 2-16:1), ER membrane palmitoleoyl-CoA(4-)[erm] + 1-acyl-sn-glycerol 3-phosphate (16:1)[erm] => coenzyme A[erm] + phosphatidate (1-16:1, 2-16:1)[erm] YOR175C Glycerolipid metabolism +r_2335 1-acyl-sn-glycerol-3-phosphate acyltransferase (1-16:1, 2-18:1), ER membrane oleoyl-CoA[erm] + 1-acyl-sn-glycerol 3-phosphate (16:1)[erm] => coenzyme A[erm] + phosphatidate (1-16:1, 2-18:1)[erm] YDL052C or YOR175C Glycerolipid metabolism +r_2336 1-acyl-sn-glycerol-3-phosphate acyltransferase (1-18:0, 2-16:1), ER membrane palmitoleoyl-CoA(4-)[erm] + 1-acyl-sn-glycerol 3-phosphate (18:0)[erm] => coenzyme A[erm] + phosphatidate (1-18:0, 2-16:1)[erm] YOR175C Glycerolipid metabolism +r_2337 1-acyl-sn-glycerol-3-phosphate acyltransferase (1-18:0, 2-18:1), ER membrane oleoyl-CoA[erm] + 1-acyl-sn-glycerol 3-phosphate (18:0)[erm] => coenzyme A[erm] + phosphatidate (1-18:0, 2-18:1)[erm] YDL052C or YOR175C Glycerolipid metabolism +r_2338 1-acyl-sn-glycerol-3-phosphate acyltransferase (1-18:1, 2-16:1), ER membrane palmitoleoyl-CoA(4-)[erm] + 1-acyl-sn-glycerol 3-phosphate (18:1)[erm] => coenzyme A[erm] + phosphatidate (1-18:1, 2-16:1)[erm] YOR175C Glycerolipid metabolism +r_2339 1-acyl-sn-glycerol-3-phosphate acyltransferase (1-18:1, 2-18:1), ER membrane oleoyl-CoA[erm] + 1-acyl-sn-glycerol 3-phosphate (18:1)[erm] => coenzyme A[erm] + phosphatidate (1-18:1, 2-18:1)[erm] YDL052C or YOR175C Glycerolipid metabolism +r_2340 1-acyl-sn-glycerol-3-phosphate acyltransferase (1-16:0, 2-18:1), lipid particle oleoyl-CoA[lp] + 1-acyl-sn-glycerol 3-phosphate (16:0)[lp] => coenzyme A[lp] + phosphatidate (1-16:0, 2-18:1)[lp] YDL052C or YKR089C or YOR081C Glycerolipid metabolism +r_2341 1-acyl-sn-glycerol-3-phosphate acyltransferase (1-16:1, 2-18:1), lipid particle oleoyl-CoA[lp] + 1-acyl-sn-glycerol 3-phosphate (16:1)[lp] => coenzyme A[lp] + phosphatidate (1-16:1, 2-18:1)[lp] YDL052C or YKR089C or YOR081C Glycerolipid metabolism +r_2342 1-acyl-sn-glycerol-3-phosphate acyltransferase (1-18:0, 2-18:1), lipid particle oleoyl-CoA[lp] + 1-acyl-sn-glycerol 3-phosphate (18:0)[lp] => coenzyme A[lp] + phosphatidate (1-18:0, 2-18:1)[lp] YDL052C or YKR089C or YOR081C Glycerolipid metabolism +r_2343 1-acyl-sn-glycerol-3-phosphate acyltransferase (1-18:1, 2-18:1), lipid particle oleoyl-CoA[lp] + 1-acyl-sn-glycerol 3-phosphate (18:1)[lp] => coenzyme A[lp] + phosphatidate (1-18:1, 2-18:1)[lp] YDL052C or YKR089C or YOR081C Glycerolipid metabolism +r_2344 PA phosphatase (1-16:0, 2-16:1), ER membrane H2O[erm] + phosphatidate (1-16:0, 2-16:1)[erm] => 2 H+[erm] + phosphate[erm] + diglyceride (1-16:0, 2-16:1)[erm] YMR165C Glycerolipid metabolism +r_2345 PA phosphatase (1-16:0, 2-18:1), ER membrane H2O[erm] + phosphatidate (1-16:0, 2-18:1)[erm] => 2 H+[erm] + phosphate[erm] + diglyceride (1-16:0, 2-18:1)[erm] YMR165C Glycerolipid metabolism +r_2346 PA phosphatase (1-16:1, 2-16:1), ER membrane H2O[erm] + phosphatidate (1-16:1, 2-16:1)[erm] => 2 H+[erm] + phosphate[erm] + diglyceride (1-16:1, 2-16:1)[erm] YMR165C Glycerolipid metabolism +r_2347 PA phosphatase (1-16:1, 2-18:1), ER membrane H2O[erm] + phosphatidate (1-16:1, 2-18:1)[erm] => 2 H+[erm] + phosphate[erm] + diglyceride (1-16:1, 2-18:1)[erm] YMR165C Glycerolipid metabolism +r_2348 PA phosphatase (1-18:0, 2-16:1), ER membrane H2O[erm] + phosphatidate (1-18:0, 2-16:1)[erm] => 2 H+[erm] + phosphate[erm] + diglyceride (1-18:0, 2-16:1)[erm] YMR165C Glycerolipid metabolism +r_2349 PA phosphatase (1-18:0, 2-18:1), ER membrane H2O[erm] + phosphatidate (1-18:0, 2-18:1)[erm] => 2 H+[erm] + phosphate[erm] + diglyceride (1-18:0, 2-18:1)[erm] YMR165C Glycerolipid metabolism +r_2350 PA phosphatase (1-18:1, 2-16:1), ER membrane H2O[erm] + phosphatidate (1-18:1, 2-16:1)[erm] => 2 H+[erm] + phosphate[erm] + diglyceride (1-18:1, 2-16:1)[erm] YMR165C Glycerolipid metabolism +r_2351 PA phosphatase (1-18:1, 2-18:1), ER membrane H2O[erm] + phosphatidate (1-18:1, 2-18:1)[erm] => 2 H+[erm] + phosphate[erm] + diglyceride (1-18:1, 2-18:1)[erm] YMR165C Glycerolipid metabolism +r_2352 PA phosphatase (1-16:0, 2-16:1), vacuolar membrane phosphatidate (1-16:0, 2-16:1)[vm] + H2O[vm] => phosphate[vm] + diglyceride (1-16:0, 2-16:1)[vm] + 2 H+[vm] YDR284C Glycerolipid metabolism +r_2353 PA phosphatase (1-16:0, 2-18:1), vacuolar membrane H2O[vm] + phosphatidate (1-16:0, 2-18:1)[vm] => phosphate[vm] + diglyceride (1-16:0, 2-18:1)[vm] + 2 H+[vm] YDR284C Glycerolipid metabolism +r_2354 PA phosphatase (1-16:1, 2-16:1), vacuolar membrane H2O[vm] + phosphatidate (1-16:1, 2-16:1)[vm] => phosphate[vm] + diglyceride (1-16:1, 2-16:1)[vm] + 2 H+[vm] YDR284C Glycerolipid metabolism +r_2355 PA phosphatase (1-16:1, 2-18:1), vacuolar membrane H2O[vm] + phosphatidate (1-16:1, 2-18:1)[vm] => phosphate[vm] + diglyceride (1-16:1, 2-18:1)[vm] + 2 H+[vm] YDR284C Glycerolipid metabolism +r_2356 PA phosphatase (1-18:0, 2-16:1), vacuolar membrane H2O[vm] + phosphatidate (1-18:0, 2-16:1)[vm] => phosphate[vm] + diglyceride (1-18:0, 2-16:1)[vm] + 2 H+[vm] YDR284C Glycerolipid metabolism +r_2357 PA phosphatase (1-18:0, 2-18:1), vacuolar membrane H2O[vm] + phosphatidate (1-18:0, 2-18:1)[vm] => phosphate[vm] + diglyceride (1-18:0, 2-18:1)[vm] + 2 H+[vm] YDR284C Glycerolipid metabolism +r_2358 PA phosphatase (1-18:1, 2-16:1), vacuolar membrane H2O[vm] + phosphatidate (1-18:1, 2-16:1)[vm] => phosphate[vm] + diglyceride (1-18:1, 2-16:1)[vm] + 2 H+[vm] YDR284C Glycerolipid metabolism +r_2359 PA phosphatase (1-18:1, 2-18:1), vacuolar membrane H2O[vm] + phosphatidate (1-18:1, 2-18:1)[vm] => phosphate[vm] + diglyceride (1-18:1, 2-18:1)[vm] + 2 H+[vm] YDR284C Glycerolipid metabolism +r_2360 PA phosphatase (1-16:0, 2-16:1), Golgi membrane phosphatidate (1-16:0, 2-16:1)[gm] + H2O[gm] => phosphate[gm] + diglyceride (1-16:0, 2-16:1)[gm] + 2 H+[gm] YDR503C Glycerolipid metabolism +r_2361 PA phosphatase (1-16:0, 2-18:1), Golgi membrane H2O[gm] + phosphatidate (1-16:0, 2-18:1)[gm] => phosphate[gm] + diglyceride (1-16:0, 2-18:1)[gm] + 2 H+[gm] YDR503C Glycerolipid metabolism +r_2362 PA phosphatase (1-16:1, 2-16:1), Golgi membrane H2O[gm] + phosphatidate (1-16:1, 2-16:1)[gm] => phosphate[gm] + diglyceride (1-16:1, 2-16:1)[gm] + 2 H+[gm] YDR503C Glycerolipid metabolism +r_2363 PA phosphatase (1-16:1, 2-18:1), Golgi membrane H2O[gm] + phosphatidate (1-16:1, 2-18:1)[gm] => phosphate[gm] + diglyceride (1-16:1, 2-18:1)[gm] + 2 H+[gm] YDR503C Glycerolipid metabolism +r_2364 PA phosphatase (1-18:0, 2-16:1), Golgi membrane H2O[gm] + phosphatidate (1-18:0, 2-16:1)[gm] => phosphate[gm] + diglyceride (1-18:0, 2-16:1)[gm] + 2 H+[gm] YDR503C Glycerolipid metabolism +r_2365 PA phosphatase (1-18:0, 2-18:1), Golgi membrane H2O[gm] + phosphatidate (1-18:0, 2-18:1)[gm] => phosphate[gm] + diglyceride (1-18:0, 2-18:1)[gm] + 2 H+[gm] YDR503C Glycerolipid metabolism +r_2366 PA phosphatase (1-18:1, 2-16:1), Golgi membrane H2O[gm] + phosphatidate (1-18:1, 2-16:1)[gm] => phosphate[gm] + diglyceride (1-18:1, 2-16:1)[gm] + 2 H+[gm] YDR503C Glycerolipid metabolism +r_2367 PA phosphatase (1-18:1, 2-18:1), Golgi membrane H2O[gm] + phosphatidate (1-18:1, 2-18:1)[gm] => phosphate[gm] + diglyceride (1-18:1, 2-18:1)[gm] + 2 H+[gm] YDR503C Glycerolipid metabolism +r_2368 diacylglycerol acyltransferase (1-16:0, 2-16:1, 3-16:0), ER membrane palmitoyl-CoA[erm] + diglyceride (1-16:0, 2-16:1)[erm] => coenzyme A[erm] + triglyceride (1-16:0, 2-16:1, 3-16:0)[erm] YCR048W or YNR019W or YOR245C Glycerolipid metabolism +r_2369 diacylglycerol acyltransferase (1-16:0, 2-18:1, 3-16:0), ER membrane palmitoyl-CoA[erm] + diglyceride (1-16:0, 2-18:1)[erm] => coenzyme A[erm] + triglyceride (1-16:0, 2-18:1, 3-16:0)[erm] YCR048W or YNR019W or YOR245C Glycerolipid metabolism +r_2370 diacylglycerol acyltransferase (1-16:1, 2-16:1, 3-16:0), ER membrane palmitoyl-CoA[erm] + diglyceride (1-16:1, 2-16:1)[erm] => coenzyme A[erm] + triglyceride (1-16:1, 2-16:1, 3-16:0)[erm] YCR048W or YNR019W or YOR245C Glycerolipid metabolism +r_2371 diacylglycerol acyltransferase (1-16:1, 2-18:1, 3-16:0), ER membrane palmitoyl-CoA[erm] + diglyceride (1-16:1, 2-18:1)[erm] => coenzyme A[erm] + triglyceride (1-16:1, 2-18:1, 3-16:0)[erm] YCR048W or YNR019W or YOR245C Glycerolipid metabolism +r_2372 diacylglycerol acyltransferase (1-18:0, 2-16:1, 3-16:0), ER membrane palmitoyl-CoA[erm] + diglyceride (1-18:0, 2-16:1)[erm] => coenzyme A[erm] + triglyceride (1-18:0, 2-16:1, 3-16:0)[erm] YCR048W or YNR019W or YOR245C Glycerolipid metabolism +r_2373 diacylglycerol acyltransferase (1-18:0, 2-18:1, 3-16:0), ER membrane palmitoyl-CoA[erm] + diglyceride (1-18:0, 2-18:1)[erm] => coenzyme A[erm] + triglyceride (1-18:0, 2-18:1, 3-16:0)[erm] YCR048W or YNR019W or YOR245C Glycerolipid metabolism +r_2374 diacylglycerol acyltransferase (1-18:1, 2-16:1, 3-16:0), ER membrane palmitoyl-CoA[erm] + diglyceride (1-18:1, 2-16:1)[erm] => coenzyme A[erm] + triglyceride (1-18:1, 2-16:1, 3-16:0)[erm] YCR048W or YNR019W or YOR245C Glycerolipid metabolism +r_2375 diacylglycerol acyltransferase (1-18:1, 2-18:1, 3-16:0), ER membrane palmitoyl-CoA[erm] + diglyceride (1-18:1, 2-18:1)[erm] => coenzyme A[erm] + triglyceride (1-18:1, 2-18:1, 3-16:0)[erm] YCR048W or YNR019W or YOR245C Glycerolipid metabolism +r_2376 diacylglycerol acyltransferase (1-16:0, 2-16:1, 3-16:1), ER membrane palmitoleoyl-CoA(4-)[erm] + diglyceride (1-16:0, 2-16:1)[erm] => coenzyme A[erm] + triglyceride (1-16:0, 2-16:1, 3-16:1)[erm] YCR048W or YNR019W or YOR245C Glycerolipid metabolism +r_2377 diacylglycerol acyltransferase (1-16:0, 2-18:1, 3-16:1), ER membrane palmitoleoyl-CoA(4-)[erm] + diglyceride (1-16:0, 2-18:1)[erm] => coenzyme A[erm] + triglyceride (1-16:0, 2-18:1, 3-16:1)[erm] YCR048W or YNR019W or YOR245C Glycerolipid metabolism +r_2378 diacylglycerol acyltransferase (1-16:1, 2-16:1, 3-16:1), ER membrane palmitoleoyl-CoA(4-)[erm] + diglyceride (1-16:1, 2-16:1)[erm] => coenzyme A[erm] + triglyceride (1-16:1, 2-16:1, 3-16:1)[erm] YCR048W or YNR019W or YOR245C Glycerolipid metabolism +r_2379 diacylglycerol acyltransferase (1-16:1, 2-18:1, 3-16:1), ER membrane palmitoleoyl-CoA(4-)[erm] + diglyceride (1-16:1, 2-18:1)[erm] => coenzyme A[erm] + triglyceride (1-16:1, 2-18:1, 3-16:1)[erm] YCR048W or YNR019W or YOR245C Glycerolipid metabolism +r_2380 diacylglycerol acyltransferase (1-18:0, 2-16:1, 3-16:1), ER membrane palmitoleoyl-CoA(4-)[erm] + diglyceride (1-18:0, 2-16:1)[erm] => coenzyme A[erm] + triglyceride (1-18:0, 2-16:1, 3-16:1)[erm] YCR048W or YNR019W or YOR245C Glycerolipid metabolism +r_2381 diacylglycerol acyltransferase (1-18:0, 2-18:1, 3-16:1), ER membrane palmitoleoyl-CoA(4-)[erm] + diglyceride (1-18:0, 2-18:1)[erm] => coenzyme A[erm] + triglyceride (1-18:0, 2-18:1, 3-16:1)[erm] YCR048W or YNR019W or YOR245C Glycerolipid metabolism +r_2382 diacylglycerol acyltransferase (1-18:1, 2-16:1, 3-16:1), ER membrane palmitoleoyl-CoA(4-)[erm] + diglyceride (1-18:1, 2-16:1)[erm] => coenzyme A[erm] + triglyceride (1-18:1, 2-16:1, 3-16:1)[erm] YCR048W or YNR019W or YOR245C Glycerolipid metabolism +r_2383 diacylglycerol acyltransferase (1-18:1, 2-18:1, 3-16:1), ER membrane palmitoleoyl-CoA(4-)[erm] + diglyceride (1-18:1, 2-18:1)[erm] => coenzyme A[erm] + triglyceride (1-18:1, 2-18:1, 3-16:1)[erm] YCR048W or YNR019W or YOR245C Glycerolipid metabolism +r_2384 diacylglycerol acyltransferase (1-16:0, 2-16:1, 3-18:0), ER membrane stearoyl-CoA[erm] + diglyceride (1-16:0, 2-16:1)[erm] => coenzyme A[erm] + triglyceride (1-16:0, 2-16:1, 3-18:0)[erm] YCR048W or YNR019W or YOR245C Glycerolipid metabolism +r_2385 diacylglycerol acyltransferase (1-16:0, 2-18:1, 3-18:0), ER membrane stearoyl-CoA[erm] + diglyceride (1-16:0, 2-18:1)[erm] => coenzyme A[erm] + triglyceride (1-16:0, 2-18:1, 3-18:0)[erm] YCR048W or YNR019W or YOR245C Glycerolipid metabolism +r_2386 diacylglycerol acyltransferase (1-16:1, 2-16:1, 3-18:0), ER membrane stearoyl-CoA[erm] + diglyceride (1-16:1, 2-16:1)[erm] => coenzyme A[erm] + triglyceride (1-16:1, 2-16:1, 3-18:0)[erm] YCR048W or YNR019W or YOR245C Glycerolipid metabolism +r_2387 diacylglycerol acyltransferase (1-16:1, 2-18:1, 3-18:0), ER membrane stearoyl-CoA[erm] + diglyceride (1-16:1, 2-18:1)[erm] => coenzyme A[erm] + triglyceride (1-16:1, 2-18:1, 3-18:0)[erm] YCR048W or YNR019W or YOR245C Glycerolipid metabolism +r_2388 diacylglycerol acyltransferase (1-18:0, 2-16:1, 3-18:0), ER membrane stearoyl-CoA[erm] + diglyceride (1-18:0, 2-16:1)[erm] => coenzyme A[erm] + triglyceride (1-18:0, 2-16:1, 3-18:0)[erm] YCR048W or YNR019W or YOR245C Glycerolipid metabolism +r_2389 diacylglycerol acyltransferase (1-18:0, 2-18:1, 3-18:0), ER membrane stearoyl-CoA[erm] + diglyceride (1-18:0, 2-18:1)[erm] => coenzyme A[erm] + triglyceride (1-18:0, 2-18:1, 3-18:0)[erm] YCR048W or YNR019W or YOR245C Glycerolipid metabolism +r_2390 diacylglycerol acyltransferase (1-18:1, 2-16:1, 3-18:0), ER membrane stearoyl-CoA[erm] + diglyceride (1-18:1, 2-16:1)[erm] => coenzyme A[erm] + triglyceride (1-18:1, 2-16:1, 3-18:0)[erm] YCR048W or YNR019W or YOR245C Glycerolipid metabolism +r_2391 diacylglycerol acyltransferase (1-18:1, 2-18:1, 3-18:0), ER membrane stearoyl-CoA[erm] + diglyceride (1-18:1, 2-18:1)[erm] => coenzyme A[erm] + triglyceride (1-18:1, 2-18:1, 3-18:0)[erm] YCR048W or YNR019W or YOR245C Glycerolipid metabolism +r_2392 diacylglycerol acyltransferase (1-16:0, 2-16:1, 3-18:1), ER membrane oleoyl-CoA[erm] + diglyceride (1-16:0, 2-16:1)[erm] => coenzyme A[erm] + triglyceride (1-16:0, 2-16:1, 3-18:1)[erm] YCR048W or YNR019W or YOR245C Glycerolipid metabolism +r_2393 diacylglycerol acyltransferase (1-16:0, 2-18:1, 3-18:1), ER membrane oleoyl-CoA[erm] + diglyceride (1-16:0, 2-18:1)[erm] => coenzyme A[erm] + triglyceride (1-16:0, 2-18:1, 3-18:1)[erm] YCR048W or YNR019W or YOR245C Glycerolipid metabolism +r_2394 diacylglycerol acyltransferase (1-16:1, 2-16:1, 3-18:1), ER membrane oleoyl-CoA[erm] + diglyceride (1-16:1, 2-16:1)[erm] => coenzyme A[erm] + triglyceride (1-16:1, 2-16:1, 3-18:1)[erm] YCR048W or YNR019W or YOR245C Glycerolipid metabolism +r_2395 diacylglycerol acyltransferase (1-16:1, 2-18:1, 3-18:1), ER membrane oleoyl-CoA[erm] + diglyceride (1-16:1, 2-18:1)[erm] => coenzyme A[erm] + triglyceride (1-16:1, 2-18:1, 3-18:1)[erm] YCR048W or YNR019W or YOR245C Glycerolipid metabolism +r_2396 diacylglycerol acyltransferase (1-18:0, 2-16:1, 3-18:1), ER membrane oleoyl-CoA[erm] + diglyceride (1-18:0, 2-16:1)[erm] => coenzyme A[erm] + triglyceride (1-18:0, 2-16:1, 3-18:1)[erm] YCR048W or YNR019W or YOR245C Glycerolipid metabolism +r_2397 diacylglycerol acyltransferase (1-18:0, 2-18:1, 3-18:1), ER membrane oleoyl-CoA[erm] + diglyceride (1-18:0, 2-18:1)[erm] => coenzyme A[erm] + triglyceride (1-18:0, 2-18:1, 3-18:1)[erm] YCR048W or YNR019W or YOR245C Glycerolipid metabolism +r_2398 diacylglycerol acyltransferase (1-18:1, 2-16:1, 3-18:1), ER membrane oleoyl-CoA[erm] + diglyceride (1-18:1, 2-16:1)[erm] => coenzyme A[erm] + triglyceride (1-18:1, 2-16:1, 3-18:1)[erm] YCR048W or YNR019W or YOR245C Glycerolipid metabolism +r_2399 diacylglycerol acyltransferase (1-18:1, 2-18:1, 3-18:1), ER membrane oleoyl-CoA[erm] + diglyceride (1-18:1, 2-18:1)[erm] => coenzyme A[erm] + triglyceride (1-18:1, 2-18:1, 3-18:1)[erm] YCR048W or YNR019W or YOR245C Glycerolipid metabolism +r_2400 diacylglycerol acyltransferase (1-16:0, 2-16:1, 3-16:0), lipid particle palmitoyl-CoA[lp] + diglyceride (1-16:0, 2-16:1)[lp] => coenzyme A[lp] + triglyceride (1-16:0, 2-16:1, 3-16:0)[lp] YOR245C Glycerolipid metabolism +r_2401 diacylglycerol acyltransferase (1-16:0, 2-18:1, 3-16:0), lipid particle palmitoyl-CoA[lp] + diglyceride (1-16:0, 2-18:1)[lp] => coenzyme A[lp] + triglyceride (1-16:0, 2-18:1, 3-16:0)[lp] YOR245C Glycerolipid metabolism +r_2402 diacylglycerol acyltransferase (1-16:1, 2-16:1, 3-16:0), lipid particle palmitoyl-CoA[lp] + diglyceride (1-16:1, 2-16:1)[lp] => coenzyme A[lp] + triglyceride (1-16:1, 2-16:1, 3-16:0)[lp] YOR245C Glycerolipid metabolism +r_2403 diacylglycerol acyltransferase (1-16:1, 2-18:1, 3-16:0), lipid particle palmitoyl-CoA[lp] + diglyceride (1-16:1, 2-18:1)[lp] => coenzyme A[lp] + triglyceride (1-16:1, 2-18:1, 3-16:0)[lp] YOR245C Glycerolipid metabolism +r_2404 diacylglycerol acyltransferase (1-18:0, 2-16:1, 3-16:0), lipid particle palmitoyl-CoA[lp] + diglyceride (1-18:0, 2-16:1)[lp] => coenzyme A[lp] + triglyceride (1-18:0, 2-16:1, 3-16:0)[lp] YOR245C Glycerolipid metabolism +r_2405 diacylglycerol acyltransferase (1-18:0, 2-18:1, 3-16:0), lipid particle palmitoyl-CoA[lp] + diglyceride (1-18:0, 2-18:1)[lp] => coenzyme A[lp] + triglyceride (1-18:0, 2-18:1, 3-16:0)[lp] YOR245C Glycerolipid metabolism +r_2406 diacylglycerol acyltransferase (1-18:1, 2-16:1, 3-16:0), lipid particle palmitoyl-CoA[lp] + diglyceride (1-18:1, 2-16:1)[lp] => coenzyme A[lp] + triglyceride (1-18:1, 2-16:1, 3-16:0)[lp] YOR245C Glycerolipid metabolism +r_2407 diacylglycerol acyltransferase (1-18:1, 2-18:1, 3-16:0), lipid particle palmitoyl-CoA[lp] + diglyceride (1-18:1, 2-18:1)[lp] => coenzyme A[lp] + triglyceride (1-18:1, 2-18:1, 3-16:0)[lp] YOR245C Glycerolipid metabolism +r_2408 diacylglycerol acyltransferase (1-16:0, 2-16:1, 3-16:1), lipid particle palmitoleoyl-CoA(4-)[lp] + diglyceride (1-16:0, 2-16:1)[lp] => coenzyme A[lp] + triglyceride (1-16:0, 2-16:1, 3-16:1)[lp] YOR245C Glycerolipid metabolism +r_2409 diacylglycerol acyltransferase (1-16:0, 2-18:1, 3-16:1), lipid particle palmitoleoyl-CoA(4-)[lp] + diglyceride (1-16:0, 2-18:1)[lp] => coenzyme A[lp] + triglyceride (1-16:0, 2-18:1, 3-16:1)[lp] YOR245C Glycerolipid metabolism +r_2410 diacylglycerol acyltransferase (1-16:1, 2-16:1, 3-16:1), lipid particle palmitoleoyl-CoA(4-)[lp] + diglyceride (1-16:1, 2-16:1)[lp] => coenzyme A[lp] + triglyceride (1-16:1, 2-16:1, 3-16:1)[lp] YOR245C Glycerolipid metabolism +r_2411 diacylglycerol acyltransferase (1-16:1, 2-18:1, 3-16:1), lipid particle palmitoleoyl-CoA(4-)[lp] + diglyceride (1-16:1, 2-18:1)[lp] => coenzyme A[lp] + triglyceride (1-16:1, 2-18:1, 3-16:1)[lp] YOR245C Glycerolipid metabolism +r_2412 diacylglycerol acyltransferase (1-18:0, 2-16:1, 3-16:1), lipid particle palmitoleoyl-CoA(4-)[lp] + diglyceride (1-18:0, 2-16:1)[lp] => coenzyme A[lp] + triglyceride (1-18:0, 2-16:1, 3-16:1)[lp] YOR245C Glycerolipid metabolism +r_2413 diacylglycerol acyltransferase (1-18:0, 2-18:1, 3-16:1), lipid particle palmitoleoyl-CoA(4-)[lp] + diglyceride (1-18:0, 2-18:1)[lp] => coenzyme A[lp] + triglyceride (1-18:0, 2-18:1, 3-16:1)[lp] YOR245C Glycerolipid metabolism +r_2414 diacylglycerol acyltransferase (1-18:1, 2-16:1, 3-16:1), lipid particle palmitoleoyl-CoA(4-)[lp] + diglyceride (1-18:1, 2-16:1)[lp] => coenzyme A[lp] + triglyceride (1-18:1, 2-16:1, 3-16:1)[lp] YOR245C Glycerolipid metabolism +r_2415 diacylglycerol acyltransferase (1-18:1, 2-18:1, 3-16:1), lipid particle palmitoleoyl-CoA(4-)[lp] + diglyceride (1-18:1, 2-18:1)[lp] => coenzyme A[lp] + triglyceride (1-18:1, 2-18:1, 3-16:1)[lp] YOR245C Glycerolipid metabolism +r_2416 diacylglycerol acyltransferase (1-16:0, 2-16:1, 3-18:0), lipid particle stearoyl-CoA[lp] + diglyceride (1-16:0, 2-16:1)[lp] => coenzyme A[lp] + triglyceride (1-16:0, 2-16:1, 3-18:0)[lp] YOR245C Glycerolipid metabolism +r_2417 diacylglycerol acyltransferase (1-16:0, 2-18:1, 3-18:0), lipid particle stearoyl-CoA[lp] + diglyceride (1-16:0, 2-18:1)[lp] => coenzyme A[lp] + triglyceride (1-16:0, 2-18:1, 3-18:0)[lp] YOR245C Glycerolipid metabolism +r_2418 diacylglycerol acyltransferase (1-16:1, 2-16:1, 3-18:0), lipid particle stearoyl-CoA[lp] + diglyceride (1-16:1, 2-16:1)[lp] => coenzyme A[lp] + triglyceride (1-16:1, 2-16:1, 3-18:0)[lp] YOR245C Glycerolipid metabolism +r_2419 diacylglycerol acyltransferase (1-16:1, 2-18:1, 3-18:0), lipid particle stearoyl-CoA[lp] + diglyceride (1-16:1, 2-18:1)[lp] => coenzyme A[lp] + triglyceride (1-16:1, 2-18:1, 3-18:0)[lp] YOR245C Glycerolipid metabolism +r_2420 diacylglycerol acyltransferase (1-18:0, 2-16:1, 3-18:0), lipid particle stearoyl-CoA[lp] + diglyceride (1-18:0, 2-16:1)[lp] => coenzyme A[lp] + triglyceride (1-18:0, 2-16:1, 3-18:0)[lp] YOR245C Glycerolipid metabolism +r_2421 diacylglycerol acyltransferase (1-18:0, 2-18:1, 3-18:0), lipid particle stearoyl-CoA[lp] + diglyceride (1-18:0, 2-18:1)[lp] => coenzyme A[lp] + triglyceride (1-18:0, 2-18:1, 3-18:0)[lp] YOR245C Glycerolipid metabolism +r_2422 diacylglycerol acyltransferase (1-18:1, 2-16:1, 3-18:0), lipid particle stearoyl-CoA[lp] + diglyceride (1-18:1, 2-16:1)[lp] => coenzyme A[lp] + triglyceride (1-18:1, 2-16:1, 3-18:0)[lp] YOR245C Glycerolipid metabolism +r_2423 diacylglycerol acyltransferase (1-18:1, 2-18:1, 3-18:0), lipid particle stearoyl-CoA[lp] + diglyceride (1-18:1, 2-18:1)[lp] => coenzyme A[lp] + triglyceride (1-18:1, 2-18:1, 3-18:0)[lp] YOR245C Glycerolipid metabolism +r_2424 diacylglycerol acyltransferase (1-16:0, 2-16:1, 3-18:1), lipid particle oleoyl-CoA[lp] + diglyceride (1-16:0, 2-16:1)[lp] => coenzyme A[lp] + triglyceride (1-16:0, 2-16:1, 3-18:1)[lp] YOR245C Glycerolipid metabolism +r_2425 diacylglycerol acyltransferase (1-16:0, 2-18:1, 3-18:1), lipid particle oleoyl-CoA[lp] + diglyceride (1-16:0, 2-18:1)[lp] => coenzyme A[lp] + triglyceride (1-16:0, 2-18:1, 3-18:1)[lp] YOR245C Glycerolipid metabolism +r_2426 diacylglycerol acyltransferase (1-16:1, 2-16:1, 3-18:1), lipid particle oleoyl-CoA[lp] + diglyceride (1-16:1, 2-16:1)[lp] => coenzyme A[lp] + triglyceride (1-16:1, 2-16:1, 3-18:1)[lp] YOR245C Glycerolipid metabolism +r_2427 diacylglycerol acyltransferase (1-16:1, 2-18:1, 3-18:1), lipid particle oleoyl-CoA[lp] + diglyceride (1-16:1, 2-18:1)[lp] => coenzyme A[lp] + triglyceride (1-16:1, 2-18:1, 3-18:1)[lp] YOR245C Glycerolipid metabolism +r_2428 diacylglycerol acyltransferase (1-18:0, 2-16:1, 3-18:1), lipid particle oleoyl-CoA[lp] + diglyceride (1-18:0, 2-16:1)[lp] => coenzyme A[lp] + triglyceride (1-18:0, 2-16:1, 3-18:1)[lp] YOR245C Glycerolipid metabolism +r_2429 diacylglycerol acyltransferase (1-18:0, 2-18:1, 3-18:1), lipid particle oleoyl-CoA[lp] + diglyceride (1-18:0, 2-18:1)[lp] => coenzyme A[lp] + triglyceride (1-18:0, 2-18:1, 3-18:1)[lp] YOR245C Glycerolipid metabolism +r_2430 diacylglycerol acyltransferase (1-18:1, 2-16:1, 3-18:1), lipid particle oleoyl-CoA[lp] + diglyceride (1-18:1, 2-16:1)[lp] => coenzyme A[lp] + triglyceride (1-18:1, 2-16:1, 3-18:1)[lp] YOR245C Glycerolipid metabolism +r_2431 diacylglycerol acyltransferase (1-18:1, 2-18:1, 3-18:1), lipid particle oleoyl-CoA[lp] + diglyceride (1-18:1, 2-18:1)[lp] => coenzyme A[lp] + triglyceride (1-18:1, 2-18:1, 3-18:1)[lp] YOR245C Glycerolipid metabolism +r_2432 CDP-diacylglycerol synthase (1-16:0, 2-16:1), ER membrane H+[erm] + phosphatidate (1-16:0, 2-16:1)[erm] + CTP[erm] <=> diphosphate[erm] + CDP-diacylglycerol (1-16:0, 2-16:1)[erm] YBR029C Glycerophospholipid metabolism +r_2433 CDP-diacylglycerol synthase (1-16:1, 2-16:1), ER membrane H+[erm] + phosphatidate (1-16:1, 2-16:1)[erm] + CTP[erm] <=> diphosphate[erm] + CDP-diacylglycerol (1-16:1, 2-16:1)[erm] YBR029C Glycerophospholipid metabolism +r_2434 CDP-diacylglycerol synthase (1-18:0, 2-16:1), ER membrane H+[erm] + phosphatidate (1-18:0, 2-16:1)[erm] + CTP[erm] <=> diphosphate[erm] + CDP-diacylglycerol (1-18:0, 2-16:1)[erm] YBR029C Glycerophospholipid metabolism +r_2435 CDP-diacylglycerol synthase (1-18:1, 2-16:1), ER membrane H+[erm] + phosphatidate (1-18:1, 2-16:1)[erm] + CTP[erm] <=> diphosphate[erm] + CDP-diacylglycerol (1-18:1, 2-16:1)[erm] YBR029C Glycerophospholipid metabolism +r_2436 CDP-diacylglycerol synthase (1-16:0, 2-18:1), ER membrane H+[erm] + phosphatidate (1-16:0, 2-18:1)[erm] + CTP[erm] <=> diphosphate[erm] + CDP-diacylglycerol (1-16:0, 2-18:1)[erm] YBR029C Glycerophospholipid metabolism +r_2437 CDP-diacylglycerol synthase (1-16:1, 2-18:1), ER membrane H+[erm] + phosphatidate (1-16:1, 2-18:1)[erm] + CTP[erm] <=> diphosphate[erm] + CDP-diacylglycerol (1-16:1, 2-18:1)[erm] YBR029C Glycerophospholipid metabolism +r_2438 CDP-diacylglycerol synthase (1-18:0, 2-18:1), ER membrane H+[erm] + phosphatidate (1-18:0, 2-18:1)[erm] + CTP[erm] <=> diphosphate[erm] + CDP-diacylglycerol (1-18:0, 2-18:1)[erm] YBR029C Glycerophospholipid metabolism +r_2439 CDP-diacylglycerol synthase (1-18:1, 2-18:1), ER membrane H+[erm] + phosphatidate (1-18:1, 2-18:1)[erm] + CTP[erm] <=> diphosphate[erm] + CDP-diacylglycerol (1-18:1, 2-18:1)[erm] YBR029C Glycerophospholipid metabolism +r_2440 CDP-diacylglycerol synthase (1-16:0, 2-16:1), mitochondrial membrane phosphatidate (1-16:0, 2-16:1)[mm] + CTP[mm] + H+[mm] <=> diphosphate[mm] + CDP-diacylglycerol (1-16:0, 2-16:1)[mm] YBR029C Glycerophospholipid metabolism +r_2441 CDP-diacylglycerol synthase (1-16:1, 2-16:1), mitochondrial membrane CTP[mm] + H+[mm] + phosphatidate (1-16:1, 2-16:1)[mm] <=> diphosphate[mm] + CDP-diacylglycerol (1-16:1, 2-16:1)[mm] YBR029C Glycerophospholipid metabolism +r_2442 CDP-diacylglycerol synthase (1-18:0, 2-16:1), mitochondrial membrane CTP[mm] + H+[mm] + phosphatidate (1-18:0, 2-16:1)[mm] <=> diphosphate[mm] + CDP-diacylglycerol (1-18:0, 2-16:1)[mm] YBR029C Glycerophospholipid metabolism +r_2443 CDP-diacylglycerol synthase (1-18:1, 2-16:1), mitochondrial membrane CTP[mm] + H+[mm] + phosphatidate (1-18:1, 2-16:1)[mm] <=> diphosphate[mm] + CDP-diacylglycerol (1-18:1, 2-16:1)[mm] YBR029C Glycerophospholipid metabolism +r_2444 CDP-diacylglycerol synthase (1-16:0, 2-18:1), mitochondrial membrane CTP[mm] + H+[mm] + phosphatidate (1-16:0, 2-18:1)[mm] <=> diphosphate[mm] + CDP-diacylglycerol (1-16:0, 2-18:1)[mm] YBR029C Glycerophospholipid metabolism +r_2445 CDP-diacylglycerol synthase (1-16:1, 2-18:1), mitochondrial membrane CTP[mm] + H+[mm] + phosphatidate (1-16:1, 2-18:1)[mm] <=> diphosphate[mm] + CDP-diacylglycerol (1-16:1, 2-18:1)[mm] YBR029C Glycerophospholipid metabolism +r_2446 PS synthase (1-16:0, 2-16:1), ER membrane CDP-diacylglycerol (1-16:0, 2-16:1)[erm] + L-serine[erm] => 2 H+[erm] + CMP[erm] + phosphatidyl-L-serine (1-16:0, 2-16:1)[erm] YER026C Glycerophospholipid metabolism +r_2447 PS synthase (1-16:1, 2-16:1), ER membrane CDP-diacylglycerol (1-16:1, 2-16:1)[erm] + L-serine[erm] => 2 H+[erm] + CMP[erm] + phosphatidyl-L-serine (1-16:1, 2-16:1)[erm] YER026C Glycerophospholipid metabolism +r_2448 PS synthase (1-18:0, 2-16:1), ER membrane CDP-diacylglycerol (1-18:0, 2-16:1)[erm] + L-serine[erm] => 2 H+[erm] + CMP[erm] + phosphatidyl-L-serine (1-18:0, 2-16:1)[erm] YER026C Glycerophospholipid metabolism +r_2449 PS synthase (1-18:1, 2-16:1), ER membrane CDP-diacylglycerol (1-18:1, 2-16:1)[erm] + L-serine[erm] => 2 H+[erm] + CMP[erm] + phosphatidyl-L-serine (1-18:1, 2-16:1)[erm] YER026C Glycerophospholipid metabolism +r_2450 PS synthase (1-16:0, 2-18:1), ER membrane CDP-diacylglycerol (1-16:0, 2-18:1)[erm] + L-serine[erm] => 2 H+[erm] + CMP[erm] + phosphatidyl-L-serine (1-16:0, 2-18:1)[erm] YER026C Glycerophospholipid metabolism +r_2451 PS synthase (1-16:1, 2-18:1), ER membrane CDP-diacylglycerol (1-16:1, 2-18:1)[erm] + L-serine[erm] => 2 H+[erm] + CMP[erm] + phosphatidyl-L-serine (1-16:1, 2-18:1)[erm] YER026C Glycerophospholipid metabolism +r_2452 PS synthase (1-18:0, 2-18:1), ER membrane CDP-diacylglycerol (1-18:0, 2-18:1)[erm] + L-serine[erm] => 2 H+[erm] + CMP[erm] + phosphatidyl-L-serine (1-18:0, 2-18:1)[erm] YER026C Glycerophospholipid metabolism +r_2453 PS synthase (1-18:1, 2-18:1), ER membrane CDP-diacylglycerol (1-18:1, 2-18:1)[erm] + L-serine[erm] => 2 H+[erm] + CMP[erm] + phosphatidyl-L-serine (1-18:1, 2-18:1)[erm] YER026C Glycerophospholipid metabolism +r_2454 PI synthase (1-16:0, 2-16:1), ER membrane CDP-diacylglycerol (1-16:0, 2-16:1)[erm] + myo-inositol[erm] => 2 H+[erm] + CMP[erm] + 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-16:1)[erm] YPR113W Inositol phosphate metabolism +r_2455 PI synthase (1-16:1, 2-16:1), ER membrane CDP-diacylglycerol (1-16:1, 2-16:1)[erm] + myo-inositol[erm] => 2 H+[erm] + CMP[erm] + 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-16:1)[erm] YPR113W Inositol phosphate metabolism +r_2456 PI synthase (1-18:0, 2-16:1), ER membrane CDP-diacylglycerol (1-18:0, 2-16:1)[erm] + myo-inositol[erm] => 2 H+[erm] + CMP[erm] + 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-16:1)[erm] YPR113W Inositol phosphate metabolism +r_2457 PI synthase (1-18:1, 2-16:1), ER membrane CDP-diacylglycerol (1-18:1, 2-16:1)[erm] + myo-inositol[erm] => 2 H+[erm] + CMP[erm] + 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-16:1)[erm] YPR113W Inositol phosphate metabolism +r_2458 PI synthase (1-16:0, 2-18:1), ER membrane CDP-diacylglycerol (1-16:0, 2-18:1)[erm] + myo-inositol[erm] => 2 H+[erm] + CMP[erm] + 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-18:1)[erm] YPR113W Inositol phosphate metabolism +r_2459 PI synthase (1-16:1, 2-18:1), ER membrane CDP-diacylglycerol (1-16:1, 2-18:1)[erm] + myo-inositol[erm] => 2 H+[erm] + CMP[erm] + 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-18:1)[erm] YPR113W Inositol phosphate metabolism +r_2460 PI synthase (1-18:0, 2-18:1), ER membrane CDP-diacylglycerol (1-18:0, 2-18:1)[erm] + myo-inositol[erm] => 2 H+[erm] + CMP[erm] + 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-18:1)[erm] YPR113W Inositol phosphate metabolism +r_2461 PI synthase (1-18:1, 2-18:1), ER membrane CDP-diacylglycerol (1-18:1, 2-18:1)[erm] + myo-inositol[erm] => 2 H+[erm] + CMP[erm] + 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-18:1)[erm] YPR113W Inositol phosphate metabolism +r_2462 lysoPI acyltransferase (1-18:0, 2-16:1), ER membrane stearoyl-CoA[erm] + sn-2-acyl-1-lysophosphatidylinositol (16:1)[erm] <=> coenzyme A[erm] + 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-16:1)[erm] YBR042C Glycerophospholipid metabolism +r_2463 lysoPI acyltransferase (1-18:0, 2-18:1), ER membrane stearoyl-CoA[erm] + sn-2-acyl-1-lysophosphatidylinositol (18:1)[erm] <=> coenzyme A[erm] + 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-18:1)[erm] YBR042C Glycerophospholipid metabolism +r_2464 PS decarboxylase (1-16:0, 2-16:1), mitochondrial membrane phosphatidyl-L-serine (1-16:0, 2-16:1)[mm] => carbon dioxide[mm] + phosphatidylethanolamine (1-16:0, 2-16:1)[mm] YNL169C Glycerophospholipid metabolism +r_2465 PS decarboxylase (1-16:1, 2-16:1), mitochondrial membrane phosphatidyl-L-serine (1-16:1, 2-16:1)[mm] => carbon dioxide[mm] + phosphatidylethanolamine (1-16:1, 2-16:1)[mm] YNL169C Glycerophospholipid metabolism +r_2466 PS decarboxylase (1-18:0, 2-16:1), mitochondrial membrane phosphatidyl-L-serine (1-18:0, 2-16:1)[mm] => carbon dioxide[mm] + phosphatidylethanolamine (1-18:0, 2-16:1)[mm] YNL169C Glycerophospholipid metabolism +r_2467 PS decarboxylase (1-18:1, 2-16:1), mitochondrial membrane phosphatidyl-L-serine (1-18:1, 2-16:1)[mm] => carbon dioxide[mm] + phosphatidylethanolamine (1-18:1, 2-16:1)[mm] YNL169C Glycerophospholipid metabolism +r_2468 PS decarboxylase (1-16:0, 2-18:1), mitochondrial membrane phosphatidyl-L-serine (1-16:0, 2-18:1)[mm] => carbon dioxide[mm] + phosphatidylethanolamine (1-16:0, 2-18:1)[mm] YNL169C Glycerophospholipid metabolism +r_2469 PS decarboxylase (1-16:1, 2-18:1), mitochondrial membrane phosphatidyl-L-serine (1-16:1, 2-18:1)[mm] => carbon dioxide[mm] + phosphatidylethanolamine (1-16:1, 2-18:1)[mm] YNL169C Glycerophospholipid metabolism +r_2470 PS decarboxylase (1-18:0, 2-18:1), mitochondrial membrane phosphatidyl-L-serine (1-18:0, 2-18:1)[mm] => carbon dioxide[mm] + phosphatidylethanolamine (1-18:0, 2-18:1)[mm] YNL169C Glycerophospholipid metabolism +r_2471 PS decarboxylase (1-18:1, 2-18:1), mitochondrial membrane phosphatidyl-L-serine (1-18:1, 2-18:1)[mm] => carbon dioxide[mm] + phosphatidylethanolamine (1-18:1, 2-18:1)[mm] YNL169C Glycerophospholipid metabolism +r_2472 PS decarboxylase (1-16:0, 2-16:1), Golgi membrane phosphatidyl-L-serine (1-16:0, 2-16:1)[gm] => carbon dioxide[gm] + phosphatidylethanolamine (1-16:0, 2-16:1)[gm] YGR170W Glycerophospholipid metabolism +r_2473 PS decarboxylase (1-16:1, 2-16:1), Golgi membrane phosphatidyl-L-serine (1-16:1, 2-16:1)[gm] => carbon dioxide[gm] + phosphatidylethanolamine (1-16:1, 2-16:1)[gm] YGR170W Glycerophospholipid metabolism +r_2474 PS decarboxylase (1-18:0, 2-16:1), Golgi membrane phosphatidyl-L-serine (1-18:0, 2-16:1)[gm] => carbon dioxide[gm] + phosphatidylethanolamine (1-18:0, 2-16:1)[gm] YGR170W Glycerophospholipid metabolism +r_2475 PS decarboxylase (1-18:1, 2-16:1), Golgi membrane phosphatidyl-L-serine (1-18:1, 2-16:1)[gm] => carbon dioxide[gm] + phosphatidylethanolamine (1-18:1, 2-16:1)[gm] YGR170W Glycerophospholipid metabolism +r_2476 PS decarboxylase (1-16:0, 2-18:1), Golgi membrane phosphatidyl-L-serine (1-16:0, 2-18:1)[gm] => carbon dioxide[gm] + phosphatidylethanolamine (1-16:0, 2-18:1)[gm] YGR170W Glycerophospholipid metabolism +r_2477 PS decarboxylase (1-16:1, 2-18:1), Golgi membrane phosphatidyl-L-serine (1-16:1, 2-18:1)[gm] => carbon dioxide[gm] + phosphatidylethanolamine (1-16:1, 2-18:1)[gm] YGR170W Glycerophospholipid metabolism +r_2478 PS decarboxylase (1-18:0, 2-18:1), Golgi membrane phosphatidyl-L-serine (1-18:0, 2-18:1)[gm] => carbon dioxide[gm] + phosphatidylethanolamine (1-18:0, 2-18:1)[gm] YGR170W Glycerophospholipid metabolism +r_2479 PS decarboxylase (1-18:1, 2-18:1), Golgi membrane phosphatidyl-L-serine (1-18:1, 2-18:1)[gm] => carbon dioxide[gm] + phosphatidylethanolamine (1-18:1, 2-18:1)[gm] YGR170W Glycerophospholipid metabolism +r_2480 PS decarboxylase (1-16:0, 2-16:1), vacuolar membrane phosphatidyl-L-serine (1-16:0, 2-16:1)[vm] => carbon dioxide[vm] + phosphatidylethanolamine (1-16:0, 2-16:1)[vm] YGR170W Glycerophospholipid metabolism +r_2481 PS decarboxylase (1-16:1, 2-16:1), vacuolar membrane phosphatidyl-L-serine (1-16:1, 2-16:1)[vm] => carbon dioxide[vm] + phosphatidylethanolamine (1-16:1, 2-16:1)[vm] YGR170W Glycerophospholipid metabolism +r_2482 PS decarboxylase (1-18:0, 2-16:1), vacuolar membrane phosphatidyl-L-serine (1-18:0, 2-16:1)[vm] => carbon dioxide[vm] + phosphatidylethanolamine (1-18:0, 2-16:1)[vm] YGR170W Glycerophospholipid metabolism +r_2483 PS decarboxylase (1-18:1, 2-16:1), vacuolar membrane phosphatidyl-L-serine (1-18:1, 2-16:1)[vm] => carbon dioxide[vm] + phosphatidylethanolamine (1-18:1, 2-16:1)[vm] YGR170W Glycerophospholipid metabolism +r_2484 PS decarboxylase (1-16:0, 2-18:1), vacuolar membrane phosphatidyl-L-serine (1-16:0, 2-18:1)[vm] => carbon dioxide[vm] + phosphatidylethanolamine (1-16:0, 2-18:1)[vm] YGR170W Glycerophospholipid metabolism +r_2485 PS decarboxylase (1-16:1, 2-18:1), vacuolar membrane phosphatidyl-L-serine (1-16:1, 2-18:1)[vm] => carbon dioxide[vm] + phosphatidylethanolamine (1-16:1, 2-18:1)[vm] YGR170W Glycerophospholipid metabolism +r_2486 PS decarboxylase (1-18:0, 2-18:1), vacuolar membrane phosphatidyl-L-serine (1-18:0, 2-18:1)[vm] => carbon dioxide[vm] + phosphatidylethanolamine (1-18:0, 2-18:1)[vm] YGR170W Glycerophospholipid metabolism +r_2487 PS decarboxylase (1-18:1, 2-18:1), vacuolar membrane phosphatidyl-L-serine (1-18:1, 2-18:1)[vm] => carbon dioxide[vm] + phosphatidylethanolamine (1-18:1, 2-18:1)[vm] YGR170W Glycerophospholipid metabolism +r_2488 PE methyltransferase (1-16:0, 2-16:1), ER membrane phosphatidylethanolamine (1-16:0, 2-16:1)[erm] + S-adenosyl-L-methionine[erm] => H+[erm] + S-adenosyl-L-homocysteine[erm] + phosphatidyl-N-methylethanolamine (1-16:0, 2-16:1)[erm] YGR157W or YJR073C Glycerophospholipid metabolism +r_2489 PE methyltransferase (1-16:1, 2-16:1), ER membrane S-adenosyl-L-methionine[erm] + phosphatidylethanolamine (1-16:1, 2-16:1)[erm] => H+[erm] + S-adenosyl-L-homocysteine[erm] + phosphatidyl-N-methylethanolamine (1-16:1, 2-16:1)[erm] YGR157W or YJR073C Glycerophospholipid metabolism +r_2490 PE methyltransferase (1-18:0, 2-16:1), ER membrane S-adenosyl-L-methionine[erm] + phosphatidylethanolamine (1-18:0, 2-16:1)[erm] => H+[erm] + S-adenosyl-L-homocysteine[erm] + phosphatidyl-N-methylethanolamine (1-18:0, 2-16:1)[erm] YGR157W or YJR073C Glycerophospholipid metabolism +r_2491 PE methyltransferase (1-18:1, 2-16:1), ER membrane S-adenosyl-L-methionine[erm] + phosphatidylethanolamine (1-18:1, 2-16:1)[erm] => H+[erm] + S-adenosyl-L-homocysteine[erm] + phosphatidyl-N-methylethanolamine (1-18:1, 2-16:1)[erm] YGR157W or YJR073C Glycerophospholipid metabolism +r_2492 PE methyltransferase (1-16:0, 2-18:1), ER membrane S-adenosyl-L-methionine[erm] + phosphatidylethanolamine (1-16:0, 2-18:1)[erm] => H+[erm] + S-adenosyl-L-homocysteine[erm] + phosphatidyl-N-methylethanolamine (1-16:0, 2-18:1)[erm] YGR157W or YJR073C Glycerophospholipid metabolism +r_2493 PE methyltransferase (1-16:1, 2-18:1), ER membrane S-adenosyl-L-methionine[erm] + phosphatidylethanolamine (1-16:1, 2-18:1)[erm] => H+[erm] + S-adenosyl-L-homocysteine[erm] + phosphatidyl-N-methylethanolamine (1-16:1, 2-18:1)[erm] YGR157W or YJR073C Glycerophospholipid metabolism +r_2494 PE methyltransferase (1-18:0, 2-18:1), ER membrane S-adenosyl-L-methionine[erm] + phosphatidylethanolamine (1-18:0, 2-18:1)[erm] => H+[erm] + S-adenosyl-L-homocysteine[erm] + phosphatidyl-N-methylethanolamine (1-18:0, 2-18:1)[erm] YGR157W or YJR073C Glycerophospholipid metabolism +r_2495 PE methyltransferase (1-18:1, 2-18:1), ER membrane S-adenosyl-L-methionine[erm] + phosphatidylethanolamine (1-18:1, 2-18:1)[erm] => H+[erm] + S-adenosyl-L-homocysteine[erm] + phosphatidyl-N-methylethanolamine (1-18:1, 2-18:1)[erm] YGR157W or YJR073C Glycerophospholipid metabolism +r_2496 phosphatidyl-N-methylethanolamine methyltransferase (1-16:0, 2-16:1), ER membrane S-adenosyl-L-methionine[erm] + phosphatidyl-N-methylethanolamine (1-16:0, 2-16:1)[erm] => H+[erm] + S-adenosyl-L-homocysteine[erm] + phosphatidyl-N,N-dimethylethanolamine (1-16:0, 2-16:1)[erm] YJR073C Glycerophospholipid metabolism +r_2497 phosphatidyl-N-methylethanolamine methyltransferase (1-16:1, 2-16:1), ER membrane S-adenosyl-L-methionine[erm] + phosphatidyl-N-methylethanolamine (1-16:1, 2-16:1)[erm] => H+[erm] + S-adenosyl-L-homocysteine[erm] + phosphatidyl-N,N-dimethylethanolamine (1-16:1, 2-16:1)[erm] YJR073C Glycerophospholipid metabolism +r_2498 phosphatidyl-N-methylethanolamine methyltransferase (1-18:0, 2-16:1), ER membrane S-adenosyl-L-methionine[erm] + phosphatidyl-N-methylethanolamine (1-18:0, 2-16:1)[erm] => H+[erm] + S-adenosyl-L-homocysteine[erm] + phosphatidyl-N,N-dimethylethanolamine (1-18:0, 2-16:1)[erm] YJR073C Glycerophospholipid metabolism +r_2499 phosphatidyl-N-methylethanolamine methyltransferase (1-18:1, 2-16:1), ER membrane S-adenosyl-L-methionine[erm] + phosphatidyl-N-methylethanolamine (1-18:1, 2-16:1)[erm] => H+[erm] + S-adenosyl-L-homocysteine[erm] + phosphatidyl-N,N-dimethylethanolamine (1-18:1, 2-16:1)[erm] YJR073C Glycerophospholipid metabolism +r_2500 phosphatidyl-N-methylethanolamine methyltransferase (1-16:0, 2-18:1), ER membrane S-adenosyl-L-methionine[erm] + phosphatidyl-N-methylethanolamine (1-16:0, 2-18:1)[erm] => H+[erm] + S-adenosyl-L-homocysteine[erm] + phosphatidyl-N,N-dimethylethanolamine (1-16:0, 2-18:1)[erm] YJR073C Glycerophospholipid metabolism +r_2501 phosphatidyl-N-methylethanolamine methyltransferase (1-16:1, 2-18:1), ER membrane S-adenosyl-L-methionine[erm] + phosphatidyl-N-methylethanolamine (1-16:1, 2-18:1)[erm] => H+[erm] + S-adenosyl-L-homocysteine[erm] + phosphatidyl-N,N-dimethylethanolamine (1-16:1, 2-18:1)[erm] YJR073C Glycerophospholipid metabolism +r_2502 phosphatidyl-N-methylethanolamine methyltransferase (1-18:0, 2-18:1), ER membrane S-adenosyl-L-methionine[erm] + phosphatidyl-N-methylethanolamine (1-18:0, 2-18:1)[erm] => H+[erm] + S-adenosyl-L-homocysteine[erm] + phosphatidyl-N,N-dimethylethanolamine (1-18:0, 2-18:1)[erm] YJR073C Glycerophospholipid metabolism +r_2503 phosphatidyl-N-methylethanolamine methyltransferase (1-18:1, 2-18:1), ER membrane S-adenosyl-L-methionine[erm] + phosphatidyl-N-methylethanolamine (1-18:1, 2-18:1)[erm] => H+[erm] + S-adenosyl-L-homocysteine[erm] + phosphatidyl-N,N-dimethylethanolamine (1-18:1, 2-18:1)[erm] YJR073C Glycerophospholipid metabolism +r_2504 phosphatidyl-N,N-dimethylethanolamine methyltransferase (1-16:0, 2-16:1), ER membrane S-adenosyl-L-methionine[erm] + phosphatidyl-N,N-dimethylethanolamine (1-16:0, 2-16:1)[erm] => H+[erm] + S-adenosyl-L-homocysteine[erm] + phosphatidylcholine (1-16:0, 2-16:1)[erm] YJR073C Glycerophospholipid metabolism +r_2505 phosphatidyl-N,N-dimethylethanolamine methyltransferase (1-16:1, 2-16:1), ER membrane S-adenosyl-L-methionine[erm] + phosphatidyl-N,N-dimethylethanolamine (1-16:1, 2-16:1)[erm] => H+[erm] + S-adenosyl-L-homocysteine[erm] + phosphatidylcholine (1-16:1, 2-16:1)[erm] YJR073C Glycerophospholipid metabolism +r_2506 phosphatidyl-N,N-dimethylethanolamine methyltransferase (1-18:0, 2-16:1), ER membrane S-adenosyl-L-methionine[erm] + phosphatidyl-N,N-dimethylethanolamine (1-18:0, 2-16:1)[erm] => H+[erm] + S-adenosyl-L-homocysteine[erm] + phosphatidylcholine (1-18:0, 2-16:1)[erm] YJR073C Glycerophospholipid metabolism +r_2507 phosphatidyl-N,N-dimethylethanolamine methyltransferase (1-18:1, 2-16:1), ER membrane S-adenosyl-L-methionine[erm] + phosphatidyl-N,N-dimethylethanolamine (1-18:1, 2-16:1)[erm] => H+[erm] + S-adenosyl-L-homocysteine[erm] + phosphatidylcholine (1-18:1, 2-16:1)[erm] YJR073C Glycerophospholipid metabolism +r_2508 phosphatidyl-N,N-dimethylethanolamine methyltransferase (1-16:0, 2-18:1), ER membrane S-adenosyl-L-methionine[erm] + phosphatidyl-N,N-dimethylethanolamine (1-16:0, 2-18:1)[erm] => H+[erm] + S-adenosyl-L-homocysteine[erm] + phosphatidylcholine (1-16:0, 2-18:1)[erm] YJR073C Glycerophospholipid metabolism +r_2509 phosphatidyl-N,N-dimethylethanolamine methyltransferase (1-16:1, 2-18:1), ER membrane S-adenosyl-L-methionine[erm] + phosphatidyl-N,N-dimethylethanolamine (1-16:1, 2-18:1)[erm] => H+[erm] + S-adenosyl-L-homocysteine[erm] + phosphatidylcholine (1-16:1, 2-18:1)[erm] YJR073C Glycerophospholipid metabolism +r_2510 phosphatidyl-N,N-dimethylethanolamine methyltransferase (1-18:0, 2-18:1), ER membrane S-adenosyl-L-methionine[erm] + phosphatidyl-N,N-dimethylethanolamine (1-18:0, 2-18:1)[erm] => H+[erm] + S-adenosyl-L-homocysteine[erm] + phosphatidylcholine (1-18:0, 2-18:1)[erm] YJR073C Glycerophospholipid metabolism +r_2511 phosphatidyl-N,N-dimethylethanolamine methyltransferase (1-18:1, 2-18:1), ER membrane S-adenosyl-L-methionine[erm] + phosphatidyl-N,N-dimethylethanolamine (1-18:1, 2-18:1)[erm] => H+[erm] + S-adenosyl-L-homocysteine[erm] + phosphatidylcholine (1-18:1, 2-18:1)[erm] YJR073C Glycerophospholipid metabolism +r_2512 DAG kinase (1-16:0, 2-16:1), ER membrane H+[erm] + diglyceride (1-16:0, 2-16:1)[erm] + CTP[erm] => phosphatidate (1-16:0, 2-16:1)[erm] + CDP[erm] YOR311C Glycerophospholipid metabolism +r_2513 DAG kinase (1-16:1, 2-16:1), ER membrane H+[erm] + diglyceride (1-16:1, 2-16:1)[erm] + CTP[erm] => phosphatidate (1-16:1, 2-16:1)[erm] + CDP[erm] YOR311C Glycerophospholipid metabolism +r_2514 DAG kinase (1-18:0, 2-16:1), ER membrane H+[erm] + diglyceride (1-18:0, 2-16:1)[erm] + CTP[erm] => phosphatidate (1-18:0, 2-16:1)[erm] + CDP[erm] YOR311C Glycerophospholipid metabolism +r_2515 DAG kinase (1-18:1, 2-16:1), ER membrane H+[erm] + diglyceride (1-18:1, 2-16:1)[erm] + CTP[erm] => phosphatidate (1-18:1, 2-16:1)[erm] + CDP[erm] YOR311C Glycerophospholipid metabolism +r_2516 DAG kinase (1-16:0, 2-18:1), ER membrane H+[erm] + diglyceride (1-16:0, 2-18:1)[erm] + CTP[erm] => phosphatidate (1-16:0, 2-18:1)[erm] + CDP[erm] YOR311C Glycerophospholipid metabolism +r_2517 DAG kinase (1-16:1, 2-18:1), ER membrane H+[erm] + diglyceride (1-16:1, 2-18:1)[erm] + CTP[erm] => phosphatidate (1-16:1, 2-18:1)[erm] + CDP[erm] YOR311C Glycerophospholipid metabolism +r_2518 DAG kinase (1-18:0, 2-18:1), ER membrane H+[erm] + diglyceride (1-18:0, 2-18:1)[erm] + CTP[erm] => phosphatidate (1-18:0, 2-18:1)[erm] + CDP[erm] YOR311C Glycerophospholipid metabolism +r_2519 DAG kinase (1-18:1, 2-18:1), ER membrane H+[erm] + diglyceride (1-18:1, 2-18:1)[erm] + CTP[erm] => phosphatidate (1-18:1, 2-18:1)[erm] + CDP[erm] YOR311C Glycerophospholipid metabolism +r_2520 ethanolaminephosphotransferase (1-16:0, 2-16:1), ER membrane diglyceride (1-16:0, 2-16:1)[erm] + CDP-ethanolamine[erm] => H+[erm] + CMP[erm] + phosphatidylethanolamine (1-16:0, 2-16:1)[erm] YHR123W Glycerophospholipid metabolism +r_2521 ethanolaminephosphotransferase (1-16:1, 2-16:1), ER membrane diglyceride (1-16:1, 2-16:1)[erm] + CDP-ethanolamine[erm] => H+[erm] + CMP[erm] + phosphatidylethanolamine (1-16:1, 2-16:1)[erm] YHR123W Glycerophospholipid metabolism +r_2522 ethanolaminephosphotransferase (1-18:0, 2-16:1), ER membrane diglyceride (1-18:0, 2-16:1)[erm] + CDP-ethanolamine[erm] => H+[erm] + CMP[erm] + phosphatidylethanolamine (1-18:0, 2-16:1)[erm] YHR123W Glycerophospholipid metabolism +r_2523 ethanolaminephosphotransferase (1-18:1, 2-16:1), ER membrane diglyceride (1-18:1, 2-16:1)[erm] + CDP-ethanolamine[erm] => H+[erm] + CMP[erm] + phosphatidylethanolamine (1-18:1, 2-16:1)[erm] YHR123W Glycerophospholipid metabolism +r_2524 ethanolaminephosphotransferase (1-16:0, 2-18:1), ER membrane diglyceride (1-16:0, 2-18:1)[erm] + CDP-ethanolamine[erm] => H+[erm] + CMP[erm] + phosphatidylethanolamine (1-16:0, 2-18:1)[erm] YHR123W Glycerophospholipid metabolism +r_2525 ethanolaminephosphotransferase (1-16:1, 2-18:1), ER membrane diglyceride (1-16:1, 2-18:1)[erm] + CDP-ethanolamine[erm] => H+[erm] + CMP[erm] + phosphatidylethanolamine (1-16:1, 2-18:1)[erm] YHR123W Glycerophospholipid metabolism +r_2526 ethanolaminephosphotransferase (1-18:0, 2-18:1), ER membrane diglyceride (1-18:0, 2-18:1)[erm] + CDP-ethanolamine[erm] => H+[erm] + CMP[erm] + phosphatidylethanolamine (1-18:0, 2-18:1)[erm] YHR123W Glycerophospholipid metabolism +r_2527 ethanolaminephosphotransferase (1-18:1, 2-18:1), ER membrane diglyceride (1-18:1, 2-18:1)[erm] + CDP-ethanolamine[erm] => H+[erm] + CMP[erm] + phosphatidylethanolamine (1-18:1, 2-18:1)[erm] YHR123W Glycerophospholipid metabolism +r_2528 cholinephosphotransferase (1-16:0, 2-16:1), ER membrane diglyceride (1-16:0, 2-16:1)[erm] + CDP-choline[erm] => H+[erm] + CMP[erm] + phosphatidylcholine (1-16:0, 2-16:1)[erm] YHR123W or YNL130C Glycerophospholipid metabolism +r_2529 cholinephosphotransferase (1-16:1, 2-16:1), ER membrane diglyceride (1-16:1, 2-16:1)[erm] + CDP-choline[erm] => H+[erm] + CMP[erm] + phosphatidylcholine (1-16:1, 2-16:1)[erm] YHR123W or YNL130C Glycerophospholipid metabolism +r_2530 cholinephosphotransferase (1-18:0, 2-16:1), ER membrane diglyceride (1-18:0, 2-16:1)[erm] + CDP-choline[erm] => H+[erm] + CMP[erm] + phosphatidylcholine (1-18:0, 2-16:1)[erm] YHR123W or YNL130C Glycerophospholipid metabolism +r_2531 cholinephosphotransferase (1-18:1, 2-16:1), ER membrane diglyceride (1-18:1, 2-16:1)[erm] + CDP-choline[erm] => H+[erm] + CMP[erm] + phosphatidylcholine (1-18:1, 2-16:1)[erm] YHR123W or YNL130C Glycerophospholipid metabolism +r_2532 cholinephosphotransferase (1-16:0, 2-18:1), ER membrane diglyceride (1-16:0, 2-18:1)[erm] + CDP-choline[erm] => H+[erm] + CMP[erm] + phosphatidylcholine (1-16:0, 2-18:1)[erm] YHR123W or YNL130C Glycerophospholipid metabolism +r_2533 cholinephosphotransferase (1-16:1, 2-18:1), ER membrane diglyceride (1-16:1, 2-18:1)[erm] + CDP-choline[erm] => H+[erm] + CMP[erm] + phosphatidylcholine (1-16:1, 2-18:1)[erm] YHR123W or YNL130C Glycerophospholipid metabolism +r_2534 cholinephosphotransferase (1-18:0, 2-18:1), ER membrane diglyceride (1-18:0, 2-18:1)[erm] + CDP-choline[erm] => H+[erm] + CMP[erm] + phosphatidylcholine (1-18:0, 2-18:1)[erm] YHR123W or YNL130C Glycerophospholipid metabolism +r_2535 cholinephosphotransferase (1-18:1, 2-18:1), ER membrane diglyceride (1-18:1, 2-18:1)[erm] + CDP-choline[erm] => H+[erm] + CMP[erm] + phosphatidylcholine (1-18:1, 2-18:1)[erm] YHR123W or YNL130C Glycerophospholipid metabolism +r_2536 phosphatidylglycerolphosphate synthase (1-16:0, 2-16:1), mitochondrial membrane CDP-diacylglycerol (1-16:0, 2-16:1)[mm] + glycerol 3-phosphate[mm] => CMP[mm] + 3-(3-sn-phosphatidyl)-sn-glycerol 1-phosphate (1-16:0, 2-16:1)[mm] YCL004W Glycerophospholipid metabolism +r_2537 phosphatidylglycerolphosphate synthase (1-16:1, 2-16:1), mitochondrial membrane CDP-diacylglycerol (1-16:1, 2-16:1)[mm] + glycerol 3-phosphate[mm] => CMP[mm] + 3-(3-sn-phosphatidyl)-sn-glycerol 1-phosphate (1-16:1, 2-16:1)[mm] YCL004W Glycerophospholipid metabolism +r_2538 phosphatidylglycerolphosphate synthase (1-18:0, 2-16:1), mitochondrial membrane CDP-diacylglycerol (1-18:0, 2-16:1)[mm] + glycerol 3-phosphate[mm] => CMP[mm] + 3-(3-sn-phosphatidyl)-sn-glycerol 1-phosphate (1-18:0, 2-16:1)[mm] YCL004W Glycerophospholipid metabolism +r_2539 phosphatidylglycerolphosphate synthase (1-18:1, 2-16:1), mitochondrial membrane CDP-diacylglycerol (1-18:1, 2-16:1)[mm] + glycerol 3-phosphate[mm] => CMP[mm] + 3-(3-sn-phosphatidyl)-sn-glycerol 1-phosphate (1-18:1, 2-16:1)[mm] YCL004W Glycerophospholipid metabolism +r_2540 phosphatidylglycerolphosphate synthase (1-16:0, 2-18:1), mitochondrial membrane CDP-diacylglycerol (1-16:0, 2-18:1)[mm] + glycerol 3-phosphate[mm] => CMP[mm] + 3-(3-sn-phosphatidyl)-sn-glycerol 1-phosphate (1-16:0, 2-18:1)[mm] YCL004W Glycerophospholipid metabolism +r_2541 phosphatidylglycerolphosphate synthase (1-16:1, 2-18:1), mitochondrial membrane CDP-diacylglycerol (1-16:1, 2-18:1)[mm] + glycerol 3-phosphate[mm] => CMP[mm] + 3-(3-sn-phosphatidyl)-sn-glycerol 1-phosphate (1-16:1, 2-18:1)[mm] YCL004W Glycerophospholipid metabolism +r_2542 PGP phosphatase (1-16:0, 2-16:1), mitochondrial membrane 3-(3-sn-phosphatidyl)-sn-glycerol 1-phosphate (1-16:0, 2-16:1)[mm] + H2O[mm] => 2 H+[mm] + phosphatidylglycerol (1-16:0, 2-16:1)[mm] + phosphate[mm] YHR100C Glycerophospholipid metabolism +r_2543 PGP phosphatase (1-16:1, 2-16:1), mitochondrial membrane 3-(3-sn-phosphatidyl)-sn-glycerol 1-phosphate (1-16:1, 2-16:1)[mm] + H2O[mm] => 2 H+[mm] + phosphate[mm] + phosphatidylglycerol (1-16:1, 2-16:1)[mm] YHR100C Glycerophospholipid metabolism +r_2544 PGP phosphatase (1-18:0, 2-16:1), mitochondrial membrane 3-(3-sn-phosphatidyl)-sn-glycerol 1-phosphate (1-18:0, 2-16:1)[mm] + H2O[mm] => 2 H+[mm] + phosphate[mm] + phosphatidylglycerol (1-18:0, 2-16:1)[mm] YHR100C Glycerophospholipid metabolism +r_2545 PGP phosphatase (1-18:1, 2-16:1), mitochondrial membrane 3-(3-sn-phosphatidyl)-sn-glycerol 1-phosphate (1-18:1, 2-16:1)[mm] + H2O[mm] => 2 H+[mm] + phosphate[mm] + phosphatidylglycerol (1-18:1, 2-16:1)[mm] YHR100C Glycerophospholipid metabolism +r_2546 PGP phosphatase (1-16:0, 2-18:1), mitochondrial membrane 3-(3-sn-phosphatidyl)-sn-glycerol 1-phosphate (1-16:0, 2-18:1)[mm] + H2O[mm] => 2 H+[mm] + phosphate[mm] + phosphatidylglycerol (1-16:0, 2-18:1)[mm] YHR100C Glycerophospholipid metabolism +r_2547 PGP phosphatase (1-16:1, 2-18:1), mitochondrial membrane 3-(3-sn-phosphatidyl)-sn-glycerol 1-phosphate (1-16:1, 2-18:1)[mm] + H2O[mm] => 2 H+[mm] + phosphate[mm] + phosphatidylglycerol (1-16:1, 2-18:1)[mm] YHR100C Glycerophospholipid metabolism +r_2548 CL synthase (1-16:0, 2-16:1, 3-16:0, 4-16:1), mitochondrial membrane CDP-diacylglycerol (1-16:0, 2-16:1)[mm] + phosphatidylglycerol (1-16:0, 2-16:1)[mm] => 2 H+[mm] + CMP[mm] + cardiolipin (1-16:0, 2-16:1, 3-16:0, 4-16:1)[mm] YDL142C Glycerophospholipid metabolism +r_2549 CL synthase (1-16:0, 2-16:1, 3-16:1, 4-16:1), mitochondrial membrane CDP-diacylglycerol (1-16:0, 2-16:1)[mm] + phosphatidylglycerol (1-16:1, 2-16:1)[mm] => 2 H+[mm] + CMP[mm] + cardiolipin (1-16:0, 2-16:1, 3-16:1, 4-16:1)[mm] YDL142C Glycerophospholipid metabolism +r_2550 CL synthase (1-16:0, 2-16:1, 3-18:0, 4-16:1), mitochondrial membrane CDP-diacylglycerol (1-16:0, 2-16:1)[mm] + phosphatidylglycerol (1-18:0, 2-16:1)[mm] => 2 H+[mm] + CMP[mm] + cardiolipin (1-16:0, 2-16:1, 3-18:0, 4-16:1)[mm] YDL142C Glycerophospholipid metabolism +r_2551 CL synthase (1-16:0, 2-16:1, 3-18:1, 4-16:1), mitochondrial membrane CDP-diacylglycerol (1-16:0, 2-16:1)[mm] + phosphatidylglycerol (1-18:1, 2-16:1)[mm] => 2 H+[mm] + CMP[mm] + cardiolipin (1-16:0, 2-16:1, 3-18:1, 4-16:1)[mm] YDL142C Glycerophospholipid metabolism +r_2552 CL synthase (1-16:0, 2-16:1, 3-16:0, 4-18:1), mitochondrial membrane CDP-diacylglycerol (1-16:0, 2-16:1)[mm] + phosphatidylglycerol (1-16:0, 2-18:1)[mm] => 2 H+[mm] + CMP[mm] + cardiolipin (1-16:0, 2-16:1, 3-16:0, 4-18:1)[mm] YDL142C Glycerophospholipid metabolism +r_2553 CL synthase (1-16:0, 2-16:1, 3-16:1, 4-18:1), mitochondrial membrane CDP-diacylglycerol (1-16:0, 2-16:1)[mm] + phosphatidylglycerol (1-16:1, 2-18:1)[mm] => 2 H+[mm] + CMP[mm] + cardiolipin (1-16:0, 2-16:1, 3-16:1, 4-18:1)[mm] YDL142C Glycerophospholipid metabolism +r_2554 CL synthase (1-16:1, 2-16:1, 3-16:0, 4-16:1), mitochondrial membrane CDP-diacylglycerol (1-16:1, 2-16:1)[mm] + phosphatidylglycerol (1-16:0, 2-16:1)[mm] => 2 H+[mm] + CMP[mm] + cardiolipin (1-16:1, 2-16:1, 3-16:0, 4-16:1)[mm] YDL142C Glycerophospholipid metabolism +r_2555 CL synthase (1-16:1, 2-16:1, 3-16:1, 4-16:1), mitochondrial membrane CDP-diacylglycerol (1-16:1, 2-16:1)[mm] + phosphatidylglycerol (1-16:1, 2-16:1)[mm] => 2 H+[mm] + CMP[mm] + cardiolipin (1-16:1, 2-16:1, 3-16:1, 4-16:1)[mm] YDL142C Glycerophospholipid metabolism +r_2556 CL synthase (1-16:1, 2-16:1, 3-18:0, 4-16:1), mitochondrial membrane CDP-diacylglycerol (1-16:1, 2-16:1)[mm] + phosphatidylglycerol (1-18:0, 2-16:1)[mm] => 2 H+[mm] + CMP[mm] + cardiolipin (1-16:1, 2-16:1, 3-18:0, 4-16:1)[mm] YDL142C Glycerophospholipid metabolism +r_2557 CL synthase (1-16:1, 2-16:1, 3-18:1, 4-16:1), mitochondrial membrane CDP-diacylglycerol (1-16:1, 2-16:1)[mm] + phosphatidylglycerol (1-18:1, 2-16:1)[mm] => 2 H+[mm] + CMP[mm] + cardiolipin (1-16:1, 2-16:1, 3-18:1, 4-16:1)[mm] YDL142C Glycerophospholipid metabolism +r_2558 CL synthase (1-16:1, 2-16:1, 3-16:0, 4-18:1), mitochondrial membrane CDP-diacylglycerol (1-16:1, 2-16:1)[mm] + phosphatidylglycerol (1-16:0, 2-18:1)[mm] => 2 H+[mm] + CMP[mm] + cardiolipin (1-16:1, 2-16:1, 3-16:0, 4-18:1)[mm] YDL142C Glycerophospholipid metabolism +r_2559 CL synthase (1-16:1, 2-16:1, 3-16:1, 4-18:1), mitochondrial membrane CDP-diacylglycerol (1-16:1, 2-16:1)[mm] + phosphatidylglycerol (1-16:1, 2-18:1)[mm] => 2 H+[mm] + CMP[mm] + cardiolipin (1-16:1, 2-16:1, 3-16:1, 4-18:1)[mm] YDL142C Glycerophospholipid metabolism +r_2560 CL synthase (1-18:0, 2-16:1, 3-16:0, 4-16:1), mitochondrial membrane CDP-diacylglycerol (1-18:0, 2-16:1)[mm] + phosphatidylglycerol (1-16:0, 2-16:1)[mm] => 2 H+[mm] + CMP[mm] + cardiolipin (1-18:0, 2-16:1, 3-16:0, 4-16:1)[mm] YDL142C Glycerophospholipid metabolism +r_2561 CL synthase (1-18:0, 2-16:1, 3-16:1, 4-16:1), mitochondrial membrane CDP-diacylglycerol (1-18:0, 2-16:1)[mm] + phosphatidylglycerol (1-16:1, 2-16:1)[mm] => 2 H+[mm] + CMP[mm] + cardiolipin (1-18:0, 2-16:1, 3-16:1, 4-16:1)[mm] YDL142C Glycerophospholipid metabolism +r_2562 CL synthase (1-18:0, 2-16:1, 3-18:0, 4-16:1), mitochondrial membrane CDP-diacylglycerol (1-18:0, 2-16:1)[mm] + phosphatidylglycerol (1-18:0, 2-16:1)[mm] => 2 H+[mm] + CMP[mm] + cardiolipin (1-18:0, 2-16:1, 3-18:0, 4-16:1)[mm] YDL142C Glycerophospholipid metabolism +r_2563 CL synthase (1-18:0, 2-16:1, 3-18:1, 4-16:1), mitochondrial membrane CDP-diacylglycerol (1-18:0, 2-16:1)[mm] + phosphatidylglycerol (1-18:1, 2-16:1)[mm] => 2 H+[mm] + CMP[mm] + cardiolipin (1-18:0, 2-16:1, 3-18:1, 4-16:1)[mm] YDL142C Glycerophospholipid metabolism +r_2564 CL synthase (1-18:0, 2-16:1, 3-16:0, 4-18:1), mitochondrial membrane CDP-diacylglycerol (1-18:0, 2-16:1)[mm] + phosphatidylglycerol (1-16:0, 2-18:1)[mm] => 2 H+[mm] + CMP[mm] + cardiolipin (1-18:0, 2-16:1, 3-16:0, 4-18:1)[mm] YDL142C Glycerophospholipid metabolism +r_2565 CL synthase (1-18:0, 2-16:1, 3-16:1, 4-18:1), mitochondrial membrane CDP-diacylglycerol (1-18:0, 2-16:1)[mm] + phosphatidylglycerol (1-16:1, 2-18:1)[mm] => 2 H+[mm] + CMP[mm] + cardiolipin (1-18:0, 2-16:1, 3-16:1, 4-18:1)[mm] YDL142C Glycerophospholipid metabolism +r_2566 CL synthase (1-18:1, 2-16:1, 3-16:0, 4-16:1), mitochondrial membrane CDP-diacylglycerol (1-18:1, 2-16:1)[mm] + phosphatidylglycerol (1-16:0, 2-16:1)[mm] => 2 H+[mm] + CMP[mm] + cardiolipin (1-18:1, 2-16:1, 3-16:0, 4-16:1)[mm] YDL142C Glycerophospholipid metabolism +r_2567 CL synthase (1-18:1, 2-16:1, 3-16:1, 4-16:1), mitochondrial membrane CDP-diacylglycerol (1-18:1, 2-16:1)[mm] + phosphatidylglycerol (1-16:1, 2-16:1)[mm] => 2 H+[mm] + CMP[mm] + cardiolipin (1-18:1, 2-16:1, 3-16:1, 4-16:1)[mm] YDL142C Glycerophospholipid metabolism +r_2568 CL synthase (1-18:1, 2-16:1, 3-18:0, 4-16:1), mitochondrial membrane CDP-diacylglycerol (1-18:1, 2-16:1)[mm] + phosphatidylglycerol (1-18:0, 2-16:1)[mm] => 2 H+[mm] + CMP[mm] + cardiolipin (1-18:1, 2-16:1, 3-18:0, 4-16:1)[mm] YDL142C Glycerophospholipid metabolism +r_2569 CL synthase (1-18:1, 2-16:1, 3-18:1, 4-16:1), mitochondrial membrane CDP-diacylglycerol (1-18:1, 2-16:1)[mm] + phosphatidylglycerol (1-18:1, 2-16:1)[mm] => 2 H+[mm] + CMP[mm] + cardiolipin (1-18:1, 2-16:1, 3-18:1, 4-16:1)[mm] YDL142C Glycerophospholipid metabolism +r_2570 CL synthase (1-18:1, 2-16:1, 3-16:0, 4-18:1), mitochondrial membrane CDP-diacylglycerol (1-18:1, 2-16:1)[mm] + phosphatidylglycerol (1-16:0, 2-18:1)[mm] => 2 H+[mm] + CMP[mm] + cardiolipin (1-18:1, 2-16:1, 3-16:0, 4-18:1)[mm] YDL142C Glycerophospholipid metabolism +r_2571 CL synthase (1-18:1, 2-16:1, 3-16:1, 4-18:1), mitochondrial membrane CDP-diacylglycerol (1-18:1, 2-16:1)[mm] + phosphatidylglycerol (1-16:1, 2-18:1)[mm] => 2 H+[mm] + CMP[mm] + cardiolipin (1-18:1, 2-16:1, 3-16:1, 4-18:1)[mm] YDL142C Glycerophospholipid metabolism +r_2572 CL synthase (1-16:0, 2-18:1, 3-16:0, 4-16:1), mitochondrial membrane CDP-diacylglycerol (1-16:0, 2-18:1)[mm] + phosphatidylglycerol (1-16:0, 2-16:1)[mm] => 2 H+[mm] + CMP[mm] + cardiolipin (1-16:0, 2-18:1, 3-16:0, 4-16:1)[mm] YDL142C Glycerophospholipid metabolism +r_2573 CL synthase (1-16:0, 2-18:1, 3-16:1, 4-16:1), mitochondrial membrane CDP-diacylglycerol (1-16:0, 2-18:1)[mm] + phosphatidylglycerol (1-16:1, 2-16:1)[mm] => 2 H+[mm] + CMP[mm] + cardiolipin (1-16:0, 2-18:1, 3-16:1, 4-16:1)[mm] YDL142C Glycerophospholipid metabolism +r_2574 CL synthase (1-16:0, 2-18:1, 3-18:0, 4-16:1), mitochondrial membrane CDP-diacylglycerol (1-16:0, 2-18:1)[mm] + phosphatidylglycerol (1-18:0, 2-16:1)[mm] => 2 H+[mm] + CMP[mm] + cardiolipin (1-16:0, 2-18:1, 3-18:0, 4-16:1)[mm] YDL142C Glycerophospholipid metabolism +r_2575 CL synthase (1-16:0, 2-18:1, 3-18:1, 4-16:1), mitochondrial membrane CDP-diacylglycerol (1-16:0, 2-18:1)[mm] + phosphatidylglycerol (1-18:1, 2-16:1)[mm] => 2 H+[mm] + CMP[mm] + cardiolipin (1-16:0, 2-18:1, 3-18:1, 4-16:1)[mm] YDL142C Glycerophospholipid metabolism +r_2576 CL synthase (1-16:0, 2-18:1, 3-16:0, 4-18:1), mitochondrial membrane CDP-diacylglycerol (1-16:0, 2-18:1)[mm] + phosphatidylglycerol (1-16:0, 2-18:1)[mm] => 2 H+[mm] + CMP[mm] + cardiolipin (1-16:0, 2-18:1, 3-16:0, 4-18:1)[mm] YDL142C Glycerophospholipid metabolism +r_2577 CL synthase (1-16:0, 2-18:1, 3-16:1, 4-18:1), mitochondrial membrane CDP-diacylglycerol (1-16:0, 2-18:1)[mm] + phosphatidylglycerol (1-16:1, 2-18:1)[mm] => 2 H+[mm] + CMP[mm] + cardiolipin (1-16:0, 2-18:1, 3-16:1, 4-18:1)[mm] YDL142C Glycerophospholipid metabolism +r_2578 CL synthase (1-16:1, 2-18:1, 3-16:0, 4-16:1), mitochondrial membrane CDP-diacylglycerol (1-16:1, 2-18:1)[mm] + phosphatidylglycerol (1-16:0, 2-16:1)[mm] => 2 H+[mm] + CMP[mm] + cardiolipin (1-16:1, 2-18:1, 3-16:0, 4-16:1)[mm] YDL142C Glycerophospholipid metabolism +r_2579 CL synthase (1-16:1, 2-18:1, 3-16:1, 4-16:1), mitochondrial membrane CDP-diacylglycerol (1-16:1, 2-18:1)[mm] + phosphatidylglycerol (1-16:1, 2-16:1)[mm] => 2 H+[mm] + CMP[mm] + cardiolipin (1-16:1, 2-18:1, 3-16:1, 4-16:1)[mm] YDL142C Glycerophospholipid metabolism +r_2580 CL synthase (1-16:1, 2-18:1, 3-18:0, 4-16:1), mitochondrial membrane CDP-diacylglycerol (1-16:1, 2-18:1)[mm] + phosphatidylglycerol (1-18:0, 2-16:1)[mm] => 2 H+[mm] + CMP[mm] + cardiolipin (1-16:1, 2-18:1, 3-18:0, 4-16:1)[mm] YDL142C Glycerophospholipid metabolism +r_2581 CL synthase (1-16:1, 2-18:1, 3-18:1, 4-16:1), mitochondrial membrane CDP-diacylglycerol (1-16:1, 2-18:1)[mm] + phosphatidylglycerol (1-18:1, 2-16:1)[mm] => 2 H+[mm] + CMP[mm] + cardiolipin (1-16:1, 2-18:1, 3-18:1, 4-16:1)[mm] YDL142C Glycerophospholipid metabolism +r_2582 CL synthase (1-16:1, 2-18:1, 3-16:0, 4-18:1), mitochondrial membrane CDP-diacylglycerol (1-16:1, 2-18:1)[mm] + phosphatidylglycerol (1-16:0, 2-18:1)[mm] => 2 H+[mm] + CMP[mm] + cardiolipin (1-16:1, 2-18:1, 3-16:0, 4-18:1)[mm] YDL142C Glycerophospholipid metabolism +r_2583 CL synthase (1-16:1, 2-18:1, 3-16:1, 4-18:1), mitochondrial membrane CDP-diacylglycerol (1-16:1, 2-18:1)[mm] + phosphatidylglycerol (1-16:1, 2-18:1)[mm] => 2 H+[mm] + CMP[mm] + cardiolipin (1-16:1, 2-18:1, 3-16:1, 4-18:1)[mm] YDL142C Glycerophospholipid metabolism +r_2584 CL (1-16:0, 2-16:1, 3-16:0, 4-16:1) phospholipase (1-position), mitochondrial membrane H2O[mm] + cardiolipin (1-16:0, 2-16:1, 3-16:0, 4-16:1)[mm] => H+[mm] + monolysocardiolipin (2-16:1, 3-16:0, 4-16:1)[mm] + palmitate[mm] YGR110W Glycerophospholipid metabolism +r_2585 CL (1-16:0, 2-16:1, 3-16:1, 4-16:1) phospholipase (1-position), mitochondrial membrane H2O[mm] + cardiolipin (1-16:0, 2-16:1, 3-16:1, 4-16:1)[mm] => H+[mm] + palmitate[mm] + monolysocardiolipin (2-16:1, 3-16:1, 4-16:1)[mm] YGR110W Glycerophospholipid metabolism +r_2586 CL (1-16:0, 2-16:1, 3-18:0, 4-16:1) phospholipase (1-position), mitochondrial membrane H2O[mm] + cardiolipin (1-16:0, 2-16:1, 3-18:0, 4-16:1)[mm] => H+[mm] + palmitate[mm] + monolysocardiolipin (2-16:1, 3-18:0, 4-16:1)[mm] YGR110W Glycerophospholipid metabolism +r_2587 CL (1-16:0, 2-16:1, 3-18:1, 4-16:1) phospholipase (1-position), mitochondrial membrane H2O[mm] + cardiolipin (1-16:0, 2-16:1, 3-18:1, 4-16:1)[mm] => H+[mm] + palmitate[mm] + monolysocardiolipin (2-16:1, 3-18:1, 4-16:1)[mm] YGR110W Glycerophospholipid metabolism +r_2588 CL (1-16:0, 2-16:1, 3-16:0, 4-18:1) phospholipase (1-position), mitochondrial membrane H2O[mm] + cardiolipin (1-16:0, 2-16:1, 3-16:0, 4-18:1)[mm] => H+[mm] + palmitate[mm] + monolysocardiolipin (2-16:1, 3-16:0, 4-18:1)[mm] YGR110W Glycerophospholipid metabolism +r_2589 CL (1-16:0, 2-16:1, 3-16:1, 4-18:1) phospholipase (1-position), mitochondrial membrane H2O[mm] + cardiolipin (1-16:0, 2-16:1, 3-16:1, 4-18:1)[mm] => H+[mm] + palmitate[mm] + monolysocardiolipin (2-16:1, 3-16:1, 4-18:1)[mm] YGR110W Glycerophospholipid metabolism +r_2590 CL (1-18:0, 2-16:1, 3-16:0, 4-16:1) phospholipase (1-position), mitochondrial membrane H2O[mm] + cardiolipin (1-18:0, 2-16:1, 3-16:0, 4-16:1)[mm] => H+[mm] + monolysocardiolipin (2-16:1, 3-16:0, 4-16:1)[mm] + stearate[mm] YGR110W Glycerophospholipid metabolism +r_2591 CL (1-18:0, 2-16:1, 3-16:1, 4-16:1) phospholipase (1-position), mitochondrial membrane H2O[mm] + cardiolipin (1-18:0, 2-16:1, 3-16:1, 4-16:1)[mm] => H+[mm] + monolysocardiolipin (2-16:1, 3-16:1, 4-16:1)[mm] + stearate[mm] YGR110W Glycerophospholipid metabolism +r_2592 CL (1-18:0, 2-16:1, 3-18:0, 4-16:1) phospholipase (1-position), mitochondrial membrane H2O[mm] + cardiolipin (1-18:0, 2-16:1, 3-18:0, 4-16:1)[mm] => H+[mm] + monolysocardiolipin (2-16:1, 3-18:0, 4-16:1)[mm] + stearate[mm] YGR110W Glycerophospholipid metabolism +r_2593 CL (1-18:0, 2-16:1, 3-18:1, 4-16:1) phospholipase (1-position), mitochondrial membrane H2O[mm] + cardiolipin (1-18:0, 2-16:1, 3-18:1, 4-16:1)[mm] => H+[mm] + monolysocardiolipin (2-16:1, 3-18:1, 4-16:1)[mm] + stearate[mm] YGR110W Glycerophospholipid metabolism +r_2594 CL (1-18:0, 2-16:1, 3-16:0, 4-18:1) phospholipase (1-position), mitochondrial membrane H2O[mm] + cardiolipin (1-18:0, 2-16:1, 3-16:0, 4-18:1)[mm] => H+[mm] + monolysocardiolipin (2-16:1, 3-16:0, 4-18:1)[mm] + stearate[mm] YGR110W Glycerophospholipid metabolism +r_2595 CL (1-18:0, 2-16:1, 3-16:1, 4-18:1) phospholipase (1-position), mitochondrial membrane H2O[mm] + cardiolipin (1-18:0, 2-16:1, 3-16:1, 4-18:1)[mm] => H+[mm] + monolysocardiolipin (2-16:1, 3-16:1, 4-18:1)[mm] + stearate[mm] YGR110W Glycerophospholipid metabolism +r_2596 CL (1-16:0, 2-18:1, 3-16:0, 4-16:1) phospholipase (1-position), mitochondrial membrane H2O[mm] + cardiolipin (1-16:0, 2-18:1, 3-16:0, 4-16:1)[mm] => H+[mm] + palmitate[mm] + monolysocardiolipin (2-18:1, 3-16:0, 4-16:1)[mm] YGR110W Glycerophospholipid metabolism +r_2597 CL (1-16:0, 2-18:1, 3-16:1, 4-16:1) phospholipase (1-position), mitochondrial membrane H2O[mm] + cardiolipin (1-16:0, 2-18:1, 3-16:1, 4-16:1)[mm] => H+[mm] + palmitate[mm] + monolysocardiolipin (2-18:1, 3-16:1, 4-16:1)[mm] YGR110W Glycerophospholipid metabolism +r_2598 CL (1-16:0, 2-18:1, 3-18:0, 4-16:1) phospholipase (1-position), mitochondrial membrane H2O[mm] + cardiolipin (1-16:0, 2-18:1, 3-18:0, 4-16:1)[mm] => H+[mm] + palmitate[mm] + monolysocardiolipin (2-18:1, 3-18:0, 4-16:1)[mm] YGR110W Glycerophospholipid metabolism +r_2599 CL (1-16:0, 2-18:1, 3-18:1, 4-16:1) phospholipase (1-position), mitochondrial membrane H2O[mm] + cardiolipin (1-16:0, 2-18:1, 3-18:1, 4-16:1)[mm] => H+[mm] + palmitate[mm] + monolysocardiolipin (2-18:1, 3-18:1, 4-16:1)[mm] YGR110W Glycerophospholipid metabolism +r_2600 CL (1-16:0, 2-18:1, 3-16:0, 4-18:1) phospholipase (1-position), mitochondrial membrane H2O[mm] + cardiolipin (1-16:0, 2-18:1, 3-16:0, 4-18:1)[mm] => H+[mm] + palmitate[mm] + monolysocardiolipin (2-18:1, 3-16:0, 4-18:1)[mm] YGR110W Glycerophospholipid metabolism +r_2601 CL (1-16:0, 2-18:1, 3-16:1, 4-18:1) phospholipase (1-position), mitochondrial membrane H2O[mm] + cardiolipin (1-16:0, 2-18:1, 3-16:1, 4-18:1)[mm] => H+[mm] + palmitate[mm] + monolysocardiolipin (2-18:1, 3-16:1, 4-18:1)[mm] YGR110W Glycerophospholipid metabolism +r_2602 CL (1-16:0, 2-16:1, 3-16:0, 4-16:1) phospholipase (3-position), mitochondrial membrane H2O[mm] + cardiolipin (1-16:0, 2-16:1, 3-16:0, 4-16:1)[mm] => H+[mm] + palmitate[mm] + monolysocardiolipin (1-16:0, 2-16:1, 4-16:1)[mm] YGR110W Glycerophospholipid metabolism +r_2603 CL (1-16:0, 2-16:1, 3-18:0, 4-16:1) phospholipase (3-position), mitochondrial membrane H2O[mm] + cardiolipin (1-16:0, 2-16:1, 3-18:0, 4-16:1)[mm] => H+[mm] + stearate[mm] + monolysocardiolipin (1-16:0, 2-16:1, 4-16:1)[mm] YGR110W Glycerophospholipid metabolism +r_2604 CL (1-16:0, 2-16:1, 3-16:0, 4-18:1) phospholipase (3-position), mitochondrial membrane H2O[mm] + cardiolipin (1-16:0, 2-16:1, 3-16:0, 4-18:1)[mm] => H+[mm] + palmitate[mm] + monolysocardiolipin (1-16:0, 2-16:1, 4-18:1)[mm] YGR110W Glycerophospholipid metabolism +r_2605 CL (1-16:1, 2-16:1, 3-16:0, 4-16:1) phospholipase (3-position), mitochondrial membrane H2O[mm] + cardiolipin (1-16:1, 2-16:1, 3-16:0, 4-16:1)[mm] => H+[mm] + palmitate[mm] + monolysocardiolipin (1-16:1, 2-16:1, 4-16:1)[mm] YGR110W Glycerophospholipid metabolism +r_2606 CL (1-16:1, 2-16:1, 3-18:0, 4-16:1) phospholipase (3-position), mitochondrial membrane H2O[mm] + cardiolipin (1-16:1, 2-16:1, 3-18:0, 4-16:1)[mm] => H+[mm] + stearate[mm] + monolysocardiolipin (1-16:1, 2-16:1, 4-16:1)[mm] YGR110W Glycerophospholipid metabolism +r_2607 CL (1-16:1, 2-16:1, 3-16:0, 4-18:1) phospholipase (3-position), mitochondrial membrane H2O[mm] + cardiolipin (1-16:1, 2-16:1, 3-16:0, 4-18:1)[mm] => H+[mm] + palmitate[mm] + monolysocardiolipin (1-16:1, 2-16:1, 4-18:1)[mm] YGR110W Glycerophospholipid metabolism +r_2608 CL (1-18:0, 2-16:1, 3-16:0, 4-16:1) phospholipase (3-position), mitochondrial membrane H2O[mm] + cardiolipin (1-18:0, 2-16:1, 3-16:0, 4-16:1)[mm] => H+[mm] + palmitate[mm] + monolysocardiolipin (1-18:0, 2-16:1, 4-16:1)[mm] YGR110W Glycerophospholipid metabolism +r_2609 CL (1-18:0, 2-16:1, 3-18:0, 4-16:1) phospholipase (3-position), mitochondrial membrane H2O[mm] + cardiolipin (1-18:0, 2-16:1, 3-18:0, 4-16:1)[mm] => H+[mm] + stearate[mm] + monolysocardiolipin (1-18:0, 2-16:1, 4-16:1)[mm] YGR110W Glycerophospholipid metabolism +r_2610 CL (1-18:0, 2-16:1, 3-16:0, 4-18:1) phospholipase (3-position), mitochondrial membrane H2O[mm] + cardiolipin (1-18:0, 2-16:1, 3-16:0, 4-18:1)[mm] => H+[mm] + palmitate[mm] + monolysocardiolipin (1-18:0, 2-16:1, 4-18:1)[mm] YGR110W Glycerophospholipid metabolism +r_2611 CL (1-18:1, 2-16:1, 3-16:0, 4-16:1) phospholipase (3-position), mitochondrial membrane H2O[mm] + cardiolipin (1-18:1, 2-16:1, 3-16:0, 4-16:1)[mm] => H+[mm] + palmitate[mm] + monolysocardiolipin (1-18:1, 2-16:1, 4-16:1)[mm] YGR110W Glycerophospholipid metabolism +r_2612 CL (1-18:1, 2-16:1, 3-18:0, 4-16:1) phospholipase (3-position), mitochondrial membrane H2O[mm] + cardiolipin (1-18:1, 2-16:1, 3-18:0, 4-16:1)[mm] => H+[mm] + stearate[mm] + monolysocardiolipin (1-18:1, 2-16:1, 4-16:1)[mm] YGR110W Glycerophospholipid metabolism +r_2613 CL (1-18:1, 2-16:1, 3-16:0, 4-18:1) phospholipase (3-position), mitochondrial membrane H2O[mm] + cardiolipin (1-18:1, 2-16:1, 3-16:0, 4-18:1)[mm] => H+[mm] + palmitate[mm] + monolysocardiolipin (1-18:1, 2-16:1, 4-18:1)[mm] YGR110W Glycerophospholipid metabolism +r_2614 CL (1-16:0, 2-18:1, 3-16:0, 4-16:1) phospholipase (3-position), mitochondrial membrane H2O[mm] + cardiolipin (1-16:0, 2-18:1, 3-16:0, 4-16:1)[mm] => H+[mm] + palmitate[mm] + monolysocardiolipin (1-16:0, 2-18:1, 4-16:1)[mm] YGR110W Glycerophospholipid metabolism +r_2615 CL (1-16:0, 2-18:1, 3-18:0, 4-16:1) phospholipase (3-position), mitochondrial membrane H2O[mm] + cardiolipin (1-16:0, 2-18:1, 3-18:0, 4-16:1)[mm] => H+[mm] + stearate[mm] + monolysocardiolipin (1-16:0, 2-18:1, 4-16:1)[mm] YGR110W Glycerophospholipid metabolism +r_2616 CL (1-16:0, 2-18:1, 3-16:0, 4-18:1) phospholipase (3-position), mitochondrial membrane H2O[mm] + cardiolipin (1-16:0, 2-18:1, 3-16:0, 4-18:1)[mm] => H+[mm] + palmitate[mm] + monolysocardiolipin (1-16:0, 2-18:1, 4-18:1)[mm] YGR110W Glycerophospholipid metabolism +r_2617 CL (1-16:1, 2-18:1, 3-16:0, 4-16:1) phospholipase (3-position), mitochondrial membrane H2O[mm] + cardiolipin (1-16:1, 2-18:1, 3-16:0, 4-16:1)[mm] => H+[mm] + palmitate[mm] + monolysocardiolipin (1-16:1, 2-18:1, 4-16:1)[mm] YGR110W Glycerophospholipid metabolism +r_2618 CL (1-16:1, 2-18:1, 3-18:0, 4-16:1) phospholipase (3-position), mitochondrial membrane H2O[mm] + cardiolipin (1-16:1, 2-18:1, 3-18:0, 4-16:1)[mm] => H+[mm] + stearate[mm] + monolysocardiolipin (1-16:1, 2-18:1, 4-16:1)[mm] YGR110W Glycerophospholipid metabolism +r_2619 CL (1-16:1, 2-18:1, 3-16:0, 4-18:1) phospholipase (3-position), mitochondrial membrane H2O[mm] + cardiolipin (1-16:1, 2-18:1, 3-16:0, 4-18:1)[mm] => H+[mm] + palmitate[mm] + monolysocardiolipin (1-16:1, 2-18:1, 4-18:1)[mm] YGR110W Glycerophospholipid metabolism +r_2620 MLCL (2-16:1, 3-16:0, 4-16:1):PC (1-16:0, 2-16:1) acyltransferase, mitochondrial membrane monolysocardiolipin (2-16:1, 3-16:0, 4-16:1)[mm] + phosphatidylcholine (1-16:0, 2-16:1)[mm] <=> cardiolipin (1-16:1, 2-16:1, 3-16:0, 4-16:1)[mm] + 1-acylglycerophosphocholine (16:0)[mm] YPR140W Glycerophospholipid metabolism +r_2621 MLCL (2-16:1, 3-16:0, 4-16:1):PC (1-16:1, 2-16:1) acyltransferase, mitochondrial membrane monolysocardiolipin (2-16:1, 3-16:0, 4-16:1)[mm] + phosphatidylcholine (1-16:1, 2-16:1)[mm] <=> cardiolipin (1-16:1, 2-16:1, 3-16:0, 4-16:1)[mm] + 1-acylglycerophosphocholine (16:1)[mm] YPR140W Glycerophospholipid metabolism +r_2622 MLCL (2-16:1, 3-16:0, 4-16:1):PC (1-18:0, 2-16:1) acyltransferase, mitochondrial membrane monolysocardiolipin (2-16:1, 3-16:0, 4-16:1)[mm] + phosphatidylcholine (1-18:0, 2-16:1)[mm] <=> cardiolipin (1-16:1, 2-16:1, 3-16:0, 4-16:1)[mm] + 1-acylglycerophosphocholine (18:0)[mm] YPR140W Glycerophospholipid metabolism +r_2623 MLCL (2-16:1, 3-16:0, 4-16:1):PC (1-18:1, 2-16:1) acyltransferase, mitochondrial membrane monolysocardiolipin (2-16:1, 3-16:0, 4-16:1)[mm] + phosphatidylcholine (1-18:1, 2-16:1)[mm] <=> cardiolipin (1-16:1, 2-16:1, 3-16:0, 4-16:1)[mm] + 1-acylglycerophosphocholine (18:1)[mm] YPR140W Glycerophospholipid metabolism +r_2624 MLCL (2-16:1, 3-16:0, 4-16:1):PC (1-16:0, 2-18:1) acyltransferase, mitochondrial membrane monolysocardiolipin (2-16:1, 3-16:0, 4-16:1)[mm] + phosphatidylcholine (1-16:0, 2-18:1)[mm] <=> cardiolipin (1-18:1, 2-16:1, 3-16:0, 4-16:1)[mm] + 1-acylglycerophosphocholine (16:0)[mm] YPR140W Glycerophospholipid metabolism +r_2625 MLCL (2-16:1, 3-16:0, 4-16:1):PC (1-16:1, 2-18:1) acyltransferase, mitochondrial membrane monolysocardiolipin (2-16:1, 3-16:0, 4-16:1)[mm] + phosphatidylcholine (1-16:1, 2-18:1)[mm] <=> cardiolipin (1-18:1, 2-16:1, 3-16:0, 4-16:1)[mm] + 1-acylglycerophosphocholine (16:1)[mm] YPR140W Glycerophospholipid metabolism +r_2626 MLCL (2-16:1, 3-16:0, 4-16:1):PC (1-18:0, 2-18:1) acyltransferase, mitochondrial membrane monolysocardiolipin (2-16:1, 3-16:0, 4-16:1)[mm] + phosphatidylcholine (1-18:0, 2-18:1)[mm] <=> cardiolipin (1-18:1, 2-16:1, 3-16:0, 4-16:1)[mm] + 1-acylglycerophosphocholine (18:0)[mm] YPR140W Glycerophospholipid metabolism +r_2627 MLCL (2-16:1, 3-16:0, 4-16:1):PC (1-18:1, 2-18:1) acyltransferase, mitochondrial membrane monolysocardiolipin (2-16:1, 3-16:0, 4-16:1)[mm] + phosphatidylcholine (1-18:1, 2-18:1)[mm] <=> cardiolipin (1-18:1, 2-16:1, 3-16:0, 4-16:1)[mm] + 1-acylglycerophosphocholine (18:1)[mm] YPR140W Glycerophospholipid metabolism +r_2628 MLCL (2-16:1, 3-16:1, 4-16:1):PC (1-16:0, 2-16:1) acyltransferase, mitochondrial membrane monolysocardiolipin (2-16:1, 3-16:1, 4-16:1)[mm] + phosphatidylcholine (1-16:0, 2-16:1)[mm] <=> cardiolipin (1-16:1, 2-16:1, 3-16:1, 4-16:1)[mm] + 1-acylglycerophosphocholine (16:0)[mm] YPR140W Glycerophospholipid metabolism +r_2629 MLCL (2-16:1, 3-16:1, 4-16:1):PC (1-16:1, 2-16:1) acyltransferase, mitochondrial membrane monolysocardiolipin (2-16:1, 3-16:1, 4-16:1)[mm] + phosphatidylcholine (1-16:1, 2-16:1)[mm] <=> cardiolipin (1-16:1, 2-16:1, 3-16:1, 4-16:1)[mm] + 1-acylglycerophosphocholine (16:1)[mm] YPR140W Glycerophospholipid metabolism +r_2630 MLCL (2-16:1, 3-16:1, 4-16:1):PC (1-18:0, 2-16:1) acyltransferase, mitochondrial membrane monolysocardiolipin (2-16:1, 3-16:1, 4-16:1)[mm] + phosphatidylcholine (1-18:0, 2-16:1)[mm] <=> cardiolipin (1-16:1, 2-16:1, 3-16:1, 4-16:1)[mm] + 1-acylglycerophosphocholine (18:0)[mm] YPR140W Glycerophospholipid metabolism +r_2631 MLCL (2-16:1, 3-16:1, 4-16:1):PC (1-18:1, 2-16:1) acyltransferase, mitochondrial membrane monolysocardiolipin (2-16:1, 3-16:1, 4-16:1)[mm] + phosphatidylcholine (1-18:1, 2-16:1)[mm] <=> cardiolipin (1-16:1, 2-16:1, 3-16:1, 4-16:1)[mm] + 1-acylglycerophosphocholine (18:1)[mm] YPR140W Glycerophospholipid metabolism +r_2632 MLCL (2-16:1, 3-16:1, 4-16:1):PC (1-16:0, 2-18:1) acyltransferase, mitochondrial membrane monolysocardiolipin (2-16:1, 3-16:1, 4-16:1)[mm] + phosphatidylcholine (1-16:0, 2-18:1)[mm] <=> cardiolipin (1-18:1, 2-16:1, 3-16:1, 4-16:1)[mm] + 1-acylglycerophosphocholine (16:0)[mm] YPR140W Glycerophospholipid metabolism +r_2633 MLCL (2-16:1, 3-16:1, 4-16:1):PC (1-16:1, 2-18:1) acyltransferase, mitochondrial membrane monolysocardiolipin (2-16:1, 3-16:1, 4-16:1)[mm] + phosphatidylcholine (1-16:1, 2-18:1)[mm] <=> cardiolipin (1-18:1, 2-16:1, 3-16:1, 4-16:1)[mm] + 1-acylglycerophosphocholine (16:1)[mm] YPR140W Glycerophospholipid metabolism +r_2634 MLCL (2-16:1, 3-16:1, 4-16:1):PC (1-18:0, 2-18:1) acyltransferase, mitochondrial membrane monolysocardiolipin (2-16:1, 3-16:1, 4-16:1)[mm] + phosphatidylcholine (1-18:0, 2-18:1)[mm] <=> cardiolipin (1-18:1, 2-16:1, 3-16:1, 4-16:1)[mm] + 1-acylglycerophosphocholine (18:0)[mm] YPR140W Glycerophospholipid metabolism +r_2635 MLCL (2-16:1, 3-16:1, 4-16:1):PC (1-18:1, 2-18:1) acyltransferase, mitochondrial membrane monolysocardiolipin (2-16:1, 3-16:1, 4-16:1)[mm] + phosphatidylcholine (1-18:1, 2-18:1)[mm] <=> cardiolipin (1-18:1, 2-16:1, 3-16:1, 4-16:1)[mm] + 1-acylglycerophosphocholine (18:1)[mm] YPR140W Glycerophospholipid metabolism +r_2636 MLCL (2-16:1, 3-18:0, 4-16:1):PC (1-16:0, 2-16:1) acyltransferase, mitochondrial membrane monolysocardiolipin (2-16:1, 3-18:0, 4-16:1)[mm] + phosphatidylcholine (1-16:0, 2-16:1)[mm] <=> cardiolipin (1-16:1, 2-16:1, 3-18:0, 4-16:1)[mm] + 1-acylglycerophosphocholine (16:0)[mm] YPR140W Glycerophospholipid metabolism +r_2637 MLCL (2-16:1, 3-18:0, 4-16:1):PC (1-16:1, 2-16:1) acyltransferase, mitochondrial membrane monolysocardiolipin (2-16:1, 3-18:0, 4-16:1)[mm] + phosphatidylcholine (1-16:1, 2-16:1)[mm] <=> cardiolipin (1-16:1, 2-16:1, 3-18:0, 4-16:1)[mm] + 1-acylglycerophosphocholine (16:1)[mm] YPR140W Glycerophospholipid metabolism +r_2638 MLCL (2-16:1, 3-18:0, 4-16:1):PC (1-18:0, 2-16:1) acyltransferase, mitochondrial membrane monolysocardiolipin (2-16:1, 3-18:0, 4-16:1)[mm] + phosphatidylcholine (1-18:0, 2-16:1)[mm] <=> cardiolipin (1-16:1, 2-16:1, 3-18:0, 4-16:1)[mm] + 1-acylglycerophosphocholine (18:0)[mm] YPR140W Glycerophospholipid metabolism +r_2639 MLCL (2-16:1, 3-18:0, 4-16:1):PC (1-18:1, 2-16:1) acyltransferase, mitochondrial membrane monolysocardiolipin (2-16:1, 3-18:0, 4-16:1)[mm] + phosphatidylcholine (1-18:1, 2-16:1)[mm] <=> cardiolipin (1-16:1, 2-16:1, 3-18:0, 4-16:1)[mm] + 1-acylglycerophosphocholine (18:1)[mm] YPR140W Glycerophospholipid metabolism +r_2640 MLCL (2-16:1, 3-18:0, 4-16:1):PC (1-16:0, 2-18:1) acyltransferase, mitochondrial membrane monolysocardiolipin (2-16:1, 3-18:0, 4-16:1)[mm] + phosphatidylcholine (1-16:0, 2-18:1)[mm] <=> cardiolipin (1-18:1, 2-16:1, 3-18:0, 4-16:1)[mm] + 1-acylglycerophosphocholine (16:0)[mm] YPR140W Glycerophospholipid metabolism +r_2641 MLCL (2-16:1, 3-18:0, 4-16:1):PC (1-16:1, 2-18:1) acyltransferase, mitochondrial membrane monolysocardiolipin (2-16:1, 3-18:0, 4-16:1)[mm] + phosphatidylcholine (1-16:1, 2-18:1)[mm] <=> cardiolipin (1-18:1, 2-16:1, 3-18:0, 4-16:1)[mm] + 1-acylglycerophosphocholine (16:1)[mm] YPR140W Glycerophospholipid metabolism +r_2642 MLCL (2-16:1, 3-18:0, 4-16:1):PC (1-18:0, 2-18:1) acyltransferase, mitochondrial membrane monolysocardiolipin (2-16:1, 3-18:0, 4-16:1)[mm] + phosphatidylcholine (1-18:0, 2-18:1)[mm] <=> cardiolipin (1-18:1, 2-16:1, 3-18:0, 4-16:1)[mm] + 1-acylglycerophosphocholine (18:0)[mm] YPR140W Glycerophospholipid metabolism +r_2643 MLCL (2-16:1, 3-18:0, 4-16:1):PC (1-18:1, 2-18:1) acyltransferase, mitochondrial membrane monolysocardiolipin (2-16:1, 3-18:0, 4-16:1)[mm] + phosphatidylcholine (1-18:1, 2-18:1)[mm] <=> cardiolipin (1-18:1, 2-16:1, 3-18:0, 4-16:1)[mm] + 1-acylglycerophosphocholine (18:1)[mm] YPR140W Glycerophospholipid metabolism +r_2644 MLCL (2-16:1, 3-18:1, 4-16:1):PC (1-16:0, 2-16:1) acyltransferase, mitochondrial membrane monolysocardiolipin (2-16:1, 3-18:1, 4-16:1)[mm] + phosphatidylcholine (1-16:0, 2-16:1)[mm] <=> cardiolipin (1-16:1, 2-16:1, 3-18:1, 4-16:1)[mm] + 1-acylglycerophosphocholine (16:0)[mm] YPR140W Glycerophospholipid metabolism +r_2645 MLCL (2-16:1, 3-18:1, 4-16:1):PC (1-16:1, 2-16:1) acyltransferase, mitochondrial membrane monolysocardiolipin (2-16:1, 3-18:1, 4-16:1)[mm] + phosphatidylcholine (1-16:1, 2-16:1)[mm] <=> cardiolipin (1-16:1, 2-16:1, 3-18:1, 4-16:1)[mm] + 1-acylglycerophosphocholine (16:1)[mm] YPR140W Glycerophospholipid metabolism +r_2646 MLCL (2-16:1, 3-18:1, 4-16:1):PC (1-18:0, 2-16:1) acyltransferase, mitochondrial membrane monolysocardiolipin (2-16:1, 3-18:1, 4-16:1)[mm] + phosphatidylcholine (1-18:0, 2-16:1)[mm] <=> cardiolipin (1-16:1, 2-16:1, 3-18:1, 4-16:1)[mm] + 1-acylglycerophosphocholine (18:0)[mm] YPR140W Glycerophospholipid metabolism +r_2647 MLCL (2-16:1, 3-18:1, 4-16:1):PC (1-18:1, 2-16:1) acyltransferase, mitochondrial membrane monolysocardiolipin (2-16:1, 3-18:1, 4-16:1)[mm] + phosphatidylcholine (1-18:1, 2-16:1)[mm] <=> cardiolipin (1-16:1, 2-16:1, 3-18:1, 4-16:1)[mm] + 1-acylglycerophosphocholine (18:1)[mm] YPR140W Glycerophospholipid metabolism +r_2648 MLCL (2-16:1, 3-18:1, 4-16:1):PC (1-16:0, 2-18:1) acyltransferase, mitochondrial membrane monolysocardiolipin (2-16:1, 3-18:1, 4-16:1)[mm] + phosphatidylcholine (1-16:0, 2-18:1)[mm] <=> cardiolipin (1-18:1, 2-16:1, 3-18:1, 4-16:1)[mm] + 1-acylglycerophosphocholine (16:0)[mm] YPR140W Glycerophospholipid metabolism +r_2649 MLCL (2-16:1, 3-18:1, 4-16:1):PC (1-16:1, 2-18:1) acyltransferase, mitochondrial membrane monolysocardiolipin (2-16:1, 3-18:1, 4-16:1)[mm] + phosphatidylcholine (1-16:1, 2-18:1)[mm] <=> cardiolipin (1-18:1, 2-16:1, 3-18:1, 4-16:1)[mm] + 1-acylglycerophosphocholine (16:1)[mm] YPR140W Glycerophospholipid metabolism +r_2650 MLCL (2-16:1, 3-18:1, 4-16:1):PC (1-18:0, 2-18:1) acyltransferase, mitochondrial membrane monolysocardiolipin (2-16:1, 3-18:1, 4-16:1)[mm] + phosphatidylcholine (1-18:0, 2-18:1)[mm] <=> cardiolipin (1-18:1, 2-16:1, 3-18:1, 4-16:1)[mm] + 1-acylglycerophosphocholine (18:0)[mm] YPR140W Glycerophospholipid metabolism +r_2651 MLCL (2-16:1, 3-18:1, 4-16:1):PC (1-18:1, 2-18:1) acyltransferase, mitochondrial membrane monolysocardiolipin (2-16:1, 3-18:1, 4-16:1)[mm] + phosphatidylcholine (1-18:1, 2-18:1)[mm] <=> cardiolipin (1-18:1, 2-16:1, 3-18:1, 4-16:1)[mm] + 1-acylglycerophosphocholine (18:1)[mm] YPR140W Glycerophospholipid metabolism +r_2652 MLCL (2-16:1, 3-16:0, 4-18:1):PC (1-16:0, 2-16:1) acyltransferase, mitochondrial membrane monolysocardiolipin (2-16:1, 3-16:0, 4-18:1)[mm] + phosphatidylcholine (1-16:0, 2-16:1)[mm] <=> cardiolipin (1-16:1, 2-16:1, 3-16:0, 4-18:1)[mm] + 1-acylglycerophosphocholine (16:0)[mm] YPR140W Glycerophospholipid metabolism +r_2653 MLCL (2-16:1, 3-16:0, 4-18:1):PC (1-16:1, 2-16:1) acyltransferase, mitochondrial membrane monolysocardiolipin (2-16:1, 3-16:0, 4-18:1)[mm] + phosphatidylcholine (1-16:1, 2-16:1)[mm] <=> cardiolipin (1-16:1, 2-16:1, 3-16:0, 4-18:1)[mm] + 1-acylglycerophosphocholine (16:1)[mm] YPR140W Glycerophospholipid metabolism +r_2654 MLCL (2-16:1, 3-16:0, 4-18:1):PC (1-18:0, 2-16:1) acyltransferase, mitochondrial membrane monolysocardiolipin (2-16:1, 3-16:0, 4-18:1)[mm] + phosphatidylcholine (1-18:0, 2-16:1)[mm] <=> cardiolipin (1-16:1, 2-16:1, 3-16:0, 4-18:1)[mm] + 1-acylglycerophosphocholine (18:0)[mm] YPR140W Glycerophospholipid metabolism +r_2655 MLCL (2-16:1, 3-16:0, 4-18:1):PC (1-18:1, 2-16:1) acyltransferase, mitochondrial membrane monolysocardiolipin (2-16:1, 3-16:0, 4-18:1)[mm] + phosphatidylcholine (1-18:1, 2-16:1)[mm] <=> cardiolipin (1-16:1, 2-16:1, 3-16:0, 4-18:1)[mm] + 1-acylglycerophosphocholine (18:1)[mm] YPR140W Glycerophospholipid metabolism +r_2656 MLCL (2-16:1, 3-16:0, 4-18:1):PC (1-16:0, 2-18:1) acyltransferase, mitochondrial membrane monolysocardiolipin (2-16:1, 3-16:0, 4-18:1)[mm] + phosphatidylcholine (1-16:0, 2-18:1)[mm] <=> cardiolipin (1-18:1, 2-16:1, 3-16:0, 4-18:1)[mm] + 1-acylglycerophosphocholine (16:0)[mm] YPR140W Glycerophospholipid metabolism +r_2657 MLCL (2-16:1, 3-16:0, 4-18:1):PC (1-16:1, 2-18:1) acyltransferase, mitochondrial membrane monolysocardiolipin (2-16:1, 3-16:0, 4-18:1)[mm] + phosphatidylcholine (1-16:1, 2-18:1)[mm] <=> cardiolipin (1-18:1, 2-16:1, 3-16:0, 4-18:1)[mm] + 1-acylglycerophosphocholine (16:1)[mm] YPR140W Glycerophospholipid metabolism +r_2658 MLCL (2-16:1, 3-16:0, 4-18:1):PC (1-18:0, 2-18:1) acyltransferase, mitochondrial membrane monolysocardiolipin (2-16:1, 3-16:0, 4-18:1)[mm] + phosphatidylcholine (1-18:0, 2-18:1)[mm] <=> cardiolipin (1-18:1, 2-16:1, 3-16:0, 4-18:1)[mm] + 1-acylglycerophosphocholine (18:0)[mm] YPR140W Glycerophospholipid metabolism +r_2659 MLCL (2-16:1, 3-16:0, 4-18:1):PC (1-18:1, 2-18:1) acyltransferase, mitochondrial membrane monolysocardiolipin (2-16:1, 3-16:0, 4-18:1)[mm] + phosphatidylcholine (1-18:1, 2-18:1)[mm] <=> cardiolipin (1-18:1, 2-16:1, 3-16:0, 4-18:1)[mm] + 1-acylglycerophosphocholine (18:1)[mm] YPR140W Glycerophospholipid metabolism +r_2660 MLCL (2-16:1, 3-16:1, 4-18:1):PC (1-16:0, 2-16:1) acyltransferase, mitochondrial membrane monolysocardiolipin (2-16:1, 3-16:1, 4-18:1)[mm] + phosphatidylcholine (1-16:0, 2-16:1)[mm] <=> cardiolipin (1-16:1, 2-16:1, 3-16:1, 4-18:1)[mm] + 1-acylglycerophosphocholine (16:0)[mm] YPR140W Glycerophospholipid metabolism +r_2661 MLCL (2-16:1, 3-16:1, 4-18:1):PC (1-16:1, 2-16:1) acyltransferase, mitochondrial membrane monolysocardiolipin (2-16:1, 3-16:1, 4-18:1)[mm] + phosphatidylcholine (1-16:1, 2-16:1)[mm] <=> cardiolipin (1-16:1, 2-16:1, 3-16:1, 4-18:1)[mm] + 1-acylglycerophosphocholine (16:1)[mm] YPR140W Glycerophospholipid metabolism +r_2662 MLCL (2-16:1, 3-16:1, 4-18:1):PC (1-18:0, 2-16:1) acyltransferase, mitochondrial membrane monolysocardiolipin (2-16:1, 3-16:1, 4-18:1)[mm] + phosphatidylcholine (1-18:0, 2-16:1)[mm] <=> cardiolipin (1-16:1, 2-16:1, 3-16:1, 4-18:1)[mm] + 1-acylglycerophosphocholine (18:0)[mm] YPR140W Glycerophospholipid metabolism +r_2663 MLCL (2-16:1, 3-16:1, 4-18:1):PC (1-18:1, 2-16:1) acyltransferase, mitochondrial membrane monolysocardiolipin (2-16:1, 3-16:1, 4-18:1)[mm] + phosphatidylcholine (1-18:1, 2-16:1)[mm] <=> cardiolipin (1-16:1, 2-16:1, 3-16:1, 4-18:1)[mm] + 1-acylglycerophosphocholine (18:1)[mm] YPR140W Glycerophospholipid metabolism +r_2664 MLCL (2-16:1, 3-16:1, 4-18:1):PC (1-16:0, 2-18:1) acyltransferase, mitochondrial membrane monolysocardiolipin (2-16:1, 3-16:1, 4-18:1)[mm] + phosphatidylcholine (1-16:0, 2-18:1)[mm] <=> cardiolipin (1-18:1, 2-16:1, 3-16:1, 4-18:1)[mm] + 1-acylglycerophosphocholine (16:0)[mm] YPR140W Glycerophospholipid metabolism +r_2665 MLCL (2-16:1, 3-16:1, 4-18:1):PC (1-16:1, 2-18:1) acyltransferase, mitochondrial membrane monolysocardiolipin (2-16:1, 3-16:1, 4-18:1)[mm] + phosphatidylcholine (1-16:1, 2-18:1)[mm] <=> cardiolipin (1-18:1, 2-16:1, 3-16:1, 4-18:1)[mm] + 1-acylglycerophosphocholine (16:1)[mm] YPR140W Glycerophospholipid metabolism +r_2666 MLCL (2-16:1, 3-16:1, 4-18:1):PC (1-18:0, 2-18:1) acyltransferase, mitochondrial membrane monolysocardiolipin (2-16:1, 3-16:1, 4-18:1)[mm] + phosphatidylcholine (1-18:0, 2-18:1)[mm] <=> cardiolipin (1-18:1, 2-16:1, 3-16:1, 4-18:1)[mm] + 1-acylglycerophosphocholine (18:0)[mm] YPR140W Glycerophospholipid metabolism +r_2667 MLCL (2-16:1, 3-16:1, 4-18:1):PC (1-18:1, 2-18:1) acyltransferase, mitochondrial membrane monolysocardiolipin (2-16:1, 3-16:1, 4-18:1)[mm] + phosphatidylcholine (1-18:1, 2-18:1)[mm] <=> cardiolipin (1-18:1, 2-16:1, 3-16:1, 4-18:1)[mm] + 1-acylglycerophosphocholine (18:1)[mm] YPR140W Glycerophospholipid metabolism +r_2668 MLCL (2-18:1, 3-16:0, 4-16:1):PC (1-16:0, 2-16:1) acyltransferase, mitochondrial membrane monolysocardiolipin (2-18:1, 3-16:0, 4-16:1)[mm] + phosphatidylcholine (1-16:0, 2-16:1)[mm] <=> cardiolipin (1-16:1, 2-18:1, 3-16:0, 4-16:1)[mm] + 1-acylglycerophosphocholine (16:0)[mm] YPR140W Glycerophospholipid metabolism +r_2669 MLCL (2-18:1, 3-16:0, 4-16:1):PC (1-16:1, 2-16:1) acyltransferase, mitochondrial membrane monolysocardiolipin (2-18:1, 3-16:0, 4-16:1)[mm] + phosphatidylcholine (1-16:1, 2-16:1)[mm] <=> cardiolipin (1-16:1, 2-18:1, 3-16:0, 4-16:1)[mm] + 1-acylglycerophosphocholine (16:1)[mm] YPR140W Glycerophospholipid metabolism +r_2670 MLCL (2-18:1, 3-16:0, 4-16:1):PC (1-18:0, 2-16:1) acyltransferase, mitochondrial membrane monolysocardiolipin (2-18:1, 3-16:0, 4-16:1)[mm] + phosphatidylcholine (1-18:0, 2-16:1)[mm] <=> cardiolipin (1-16:1, 2-18:1, 3-16:0, 4-16:1)[mm] + 1-acylglycerophosphocholine (18:0)[mm] YPR140W Glycerophospholipid metabolism +r_2671 MLCL (2-18:1, 3-16:0, 4-16:1):PC (1-18:1, 2-16:1) acyltransferase, mitochondrial membrane monolysocardiolipin (2-18:1, 3-16:0, 4-16:1)[mm] + phosphatidylcholine (1-18:1, 2-16:1)[mm] <=> cardiolipin (1-16:1, 2-18:1, 3-16:0, 4-16:1)[mm] + 1-acylglycerophosphocholine (18:1)[mm] YPR140W Glycerophospholipid metabolism +r_2672 MLCL (2-18:1, 3-16:0, 4-16:1):PC (1-16:0, 2-18:1) acyltransferase, mitochondrial membrane monolysocardiolipin (2-18:1, 3-16:0, 4-16:1)[mm] + phosphatidylcholine (1-16:0, 2-18:1)[mm] <=> 1-acylglycerophosphocholine (16:0)[mm] + cardiolipin (1-18:1, 2-18:1, 3-16:0, 4-16:1)[mm] YPR140W Glycerophospholipid metabolism +r_2673 MLCL (2-18:1, 3-16:0, 4-16:1):PC (1-16:1, 2-18:1) acyltransferase, mitochondrial membrane monolysocardiolipin (2-18:1, 3-16:0, 4-16:1)[mm] + phosphatidylcholine (1-16:1, 2-18:1)[mm] <=> 1-acylglycerophosphocholine (16:1)[mm] + cardiolipin (1-18:1, 2-18:1, 3-16:0, 4-16:1)[mm] YPR140W Glycerophospholipid metabolism +r_2674 MLCL (2-18:1, 3-16:0, 4-16:1):PC (1-18:0, 2-18:1) acyltransferase, mitochondrial membrane monolysocardiolipin (2-18:1, 3-16:0, 4-16:1)[mm] + phosphatidylcholine (1-18:0, 2-18:1)[mm] <=> 1-acylglycerophosphocholine (18:0)[mm] + cardiolipin (1-18:1, 2-18:1, 3-16:0, 4-16:1)[mm] YPR140W Glycerophospholipid metabolism +r_2675 MLCL (2-18:1, 3-16:0, 4-16:1):PC (1-18:1, 2-18:1) acyltransferase, mitochondrial membrane monolysocardiolipin (2-18:1, 3-16:0, 4-16:1)[mm] + phosphatidylcholine (1-18:1, 2-18:1)[mm] <=> 1-acylglycerophosphocholine (18:1)[mm] + cardiolipin (1-18:1, 2-18:1, 3-16:0, 4-16:1)[mm] YPR140W Glycerophospholipid metabolism +r_2676 MLCL (2-18:1, 3-16:1, 4-16:1):PC (1-16:0, 2-16:1) acyltransferase, mitochondrial membrane monolysocardiolipin (2-18:1, 3-16:1, 4-16:1)[mm] + phosphatidylcholine (1-16:0, 2-16:1)[mm] <=> cardiolipin (1-16:1, 2-18:1, 3-16:1, 4-16:1)[mm] + 1-acylglycerophosphocholine (16:0)[mm] YPR140W Glycerophospholipid metabolism +r_2677 MLCL (2-18:1, 3-16:1, 4-16:1):PC (1-16:1, 2-16:1) acyltransferase, mitochondrial membrane monolysocardiolipin (2-18:1, 3-16:1, 4-16:1)[mm] + phosphatidylcholine (1-16:1, 2-16:1)[mm] <=> cardiolipin (1-16:1, 2-18:1, 3-16:1, 4-16:1)[mm] + 1-acylglycerophosphocholine (16:1)[mm] YPR140W Glycerophospholipid metabolism +r_2678 MLCL (2-18:1, 3-16:1, 4-16:1):PC (1-18:0, 2-16:1) acyltransferase, mitochondrial membrane monolysocardiolipin (2-18:1, 3-16:1, 4-16:1)[mm] + phosphatidylcholine (1-18:0, 2-16:1)[mm] <=> cardiolipin (1-16:1, 2-18:1, 3-16:1, 4-16:1)[mm] + 1-acylglycerophosphocholine (18:0)[mm] YPR140W Glycerophospholipid metabolism +r_2679 MLCL (2-18:1, 3-16:1, 4-16:1):PC (1-18:1, 2-16:1) acyltransferase, mitochondrial membrane monolysocardiolipin (2-18:1, 3-16:1, 4-16:1)[mm] + phosphatidylcholine (1-18:1, 2-16:1)[mm] <=> cardiolipin (1-16:1, 2-18:1, 3-16:1, 4-16:1)[mm] + 1-acylglycerophosphocholine (18:1)[mm] YPR140W Glycerophospholipid metabolism +r_2680 MLCL (2-18:1, 3-16:1, 4-16:1):PC (1-16:0, 2-18:1) acyltransferase, mitochondrial membrane monolysocardiolipin (2-18:1, 3-16:1, 4-16:1)[mm] + phosphatidylcholine (1-16:0, 2-18:1)[mm] <=> 1-acylglycerophosphocholine (16:0)[mm] + cardiolipin (1-18:1, 2-18:1, 3-16:1, 4-16:1)[mm] YPR140W Glycerophospholipid metabolism +r_2681 MLCL (2-18:1, 3-16:1, 4-16:1):PC (1-16:1, 2-18:1) acyltransferase, mitochondrial membrane monolysocardiolipin (2-18:1, 3-16:1, 4-16:1)[mm] + phosphatidylcholine (1-16:1, 2-18:1)[mm] <=> 1-acylglycerophosphocholine (16:1)[mm] + cardiolipin (1-18:1, 2-18:1, 3-16:1, 4-16:1)[mm] YPR140W Glycerophospholipid metabolism +r_2682 MLCL (2-18:1, 3-16:1, 4-16:1):PC (1-18:0, 2-18:1) acyltransferase, mitochondrial membrane monolysocardiolipin (2-18:1, 3-16:1, 4-16:1)[mm] + phosphatidylcholine (1-18:0, 2-18:1)[mm] <=> 1-acylglycerophosphocholine (18:0)[mm] + cardiolipin (1-18:1, 2-18:1, 3-16:1, 4-16:1)[mm] YPR140W Glycerophospholipid metabolism +r_2683 MLCL (2-18:1, 3-16:1, 4-16:1):PC (1-18:1, 2-18:1) acyltransferase, mitochondrial membrane monolysocardiolipin (2-18:1, 3-16:1, 4-16:1)[mm] + phosphatidylcholine (1-18:1, 2-18:1)[mm] <=> 1-acylglycerophosphocholine (18:1)[mm] + cardiolipin (1-18:1, 2-18:1, 3-16:1, 4-16:1)[mm] YPR140W Glycerophospholipid metabolism +r_2684 MLCL (2-18:1, 3-18:0, 4-16:1):PC (1-16:0, 2-16:1) acyltransferase, mitochondrial membrane monolysocardiolipin (2-18:1, 3-18:0, 4-16:1)[mm] + phosphatidylcholine (1-16:0, 2-16:1)[mm] <=> cardiolipin (1-16:1, 2-18:1, 3-18:0, 4-16:1)[mm] + 1-acylglycerophosphocholine (16:0)[mm] YPR140W Glycerophospholipid metabolism +r_2685 MLCL (2-18:1, 3-18:0, 4-16:1):PC (1-16:1, 2-16:1) acyltransferase, mitochondrial membrane monolysocardiolipin (2-18:1, 3-18:0, 4-16:1)[mm] + phosphatidylcholine (1-16:1, 2-16:1)[mm] <=> cardiolipin (1-16:1, 2-18:1, 3-18:0, 4-16:1)[mm] + 1-acylglycerophosphocholine (16:1)[mm] YPR140W Glycerophospholipid metabolism +r_2686 MLCL (2-18:1, 3-18:0, 4-16:1):PC (1-18:0, 2-16:1) acyltransferase, mitochondrial membrane monolysocardiolipin (2-18:1, 3-18:0, 4-16:1)[mm] + phosphatidylcholine (1-18:0, 2-16:1)[mm] <=> cardiolipin (1-16:1, 2-18:1, 3-18:0, 4-16:1)[mm] + 1-acylglycerophosphocholine (18:0)[mm] YPR140W Glycerophospholipid metabolism +r_2687 MLCL (2-18:1, 3-18:0, 4-16:1):PC (1-18:1, 2-16:1) acyltransferase, mitochondrial membrane monolysocardiolipin (2-18:1, 3-18:0, 4-16:1)[mm] + phosphatidylcholine (1-18:1, 2-16:1)[mm] <=> cardiolipin (1-16:1, 2-18:1, 3-18:0, 4-16:1)[mm] + 1-acylglycerophosphocholine (18:1)[mm] YPR140W Glycerophospholipid metabolism +r_2688 MLCL (2-18:1, 3-18:0, 4-16:1):PC (1-16:0, 2-18:1) acyltransferase, mitochondrial membrane monolysocardiolipin (2-18:1, 3-18:0, 4-16:1)[mm] + phosphatidylcholine (1-16:0, 2-18:1)[mm] <=> 1-acylglycerophosphocholine (16:0)[mm] + cardiolipin (1-18:1, 2-18:1, 3-18:0, 4-16:1)[mm] YPR140W Glycerophospholipid metabolism +r_2689 MLCL (2-18:1, 3-18:0, 4-16:1):PC (1-16:1, 2-18:1) acyltransferase, mitochondrial membrane monolysocardiolipin (2-18:1, 3-18:0, 4-16:1)[mm] + phosphatidylcholine (1-16:1, 2-18:1)[mm] <=> 1-acylglycerophosphocholine (16:1)[mm] + cardiolipin (1-18:1, 2-18:1, 3-18:0, 4-16:1)[mm] YPR140W Glycerophospholipid metabolism +r_2690 MLCL (2-18:1, 3-18:0, 4-16:1):PC (1-18:0, 2-18:1) acyltransferase, mitochondrial membrane monolysocardiolipin (2-18:1, 3-18:0, 4-16:1)[mm] + phosphatidylcholine (1-18:0, 2-18:1)[mm] <=> 1-acylglycerophosphocholine (18:0)[mm] + cardiolipin (1-18:1, 2-18:1, 3-18:0, 4-16:1)[mm] YPR140W Glycerophospholipid metabolism +r_2691 MLCL (2-18:1, 3-18:0, 4-16:1):PC (1-18:1, 2-18:1) acyltransferase, mitochondrial membrane monolysocardiolipin (2-18:1, 3-18:0, 4-16:1)[mm] + phosphatidylcholine (1-18:1, 2-18:1)[mm] <=> 1-acylglycerophosphocholine (18:1)[mm] + cardiolipin (1-18:1, 2-18:1, 3-18:0, 4-16:1)[mm] YPR140W Glycerophospholipid metabolism +r_2692 MLCL (2-18:1, 3-18:1, 4-16:1):PC (1-16:0, 2-16:1) acyltransferase, mitochondrial membrane monolysocardiolipin (2-18:1, 3-18:1, 4-16:1)[mm] + phosphatidylcholine (1-16:0, 2-16:1)[mm] <=> cardiolipin (1-16:1, 2-18:1, 3-18:1, 4-16:1)[mm] + 1-acylglycerophosphocholine (16:0)[mm] YPR140W Glycerophospholipid metabolism +r_2693 MLCL (2-18:1, 3-18:1, 4-16:1):PC (1-16:1, 2-16:1) acyltransferase, mitochondrial membrane monolysocardiolipin (2-18:1, 3-18:1, 4-16:1)[mm] + phosphatidylcholine (1-16:1, 2-16:1)[mm] <=> cardiolipin (1-16:1, 2-18:1, 3-18:1, 4-16:1)[mm] + 1-acylglycerophosphocholine (16:1)[mm] YPR140W Glycerophospholipid metabolism +r_2694 MLCL (2-18:1, 3-18:1, 4-16:1):PC (1-18:0, 2-16:1) acyltransferase, mitochondrial membrane monolysocardiolipin (2-18:1, 3-18:1, 4-16:1)[mm] + phosphatidylcholine (1-18:0, 2-16:1)[mm] <=> cardiolipin (1-16:1, 2-18:1, 3-18:1, 4-16:1)[mm] + 1-acylglycerophosphocholine (18:0)[mm] YPR140W Glycerophospholipid metabolism +r_2695 MLCL (2-18:1, 3-18:1, 4-16:1):PC (1-18:1, 2-16:1) acyltransferase, mitochondrial membrane monolysocardiolipin (2-18:1, 3-18:1, 4-16:1)[mm] + phosphatidylcholine (1-18:1, 2-16:1)[mm] <=> cardiolipin (1-16:1, 2-18:1, 3-18:1, 4-16:1)[mm] + 1-acylglycerophosphocholine (18:1)[mm] YPR140W Glycerophospholipid metabolism +r_2696 MLCL (2-18:1, 3-18:1, 4-16:1):PC (1-16:0, 2-18:1) acyltransferase, mitochondrial membrane monolysocardiolipin (2-18:1, 3-18:1, 4-16:1)[mm] + phosphatidylcholine (1-16:0, 2-18:1)[mm] <=> 1-acylglycerophosphocholine (16:0)[mm] + cardiolipin (1-18:1, 2-18:1, 3-18:1, 4-16:1)[mm] YPR140W Glycerophospholipid metabolism +r_2697 MLCL (2-18:1, 3-18:1, 4-16:1):PC (1-16:1, 2-18:1) acyltransferase, mitochondrial membrane monolysocardiolipin (2-18:1, 3-18:1, 4-16:1)[mm] + phosphatidylcholine (1-16:1, 2-18:1)[mm] <=> 1-acylglycerophosphocholine (16:1)[mm] + cardiolipin (1-18:1, 2-18:1, 3-18:1, 4-16:1)[mm] YPR140W Glycerophospholipid metabolism +r_2698 MLCL (2-18:1, 3-18:1, 4-16:1):PC (1-18:0, 2-18:1) acyltransferase, mitochondrial membrane monolysocardiolipin (2-18:1, 3-18:1, 4-16:1)[mm] + phosphatidylcholine (1-18:0, 2-18:1)[mm] <=> 1-acylglycerophosphocholine (18:0)[mm] + cardiolipin (1-18:1, 2-18:1, 3-18:1, 4-16:1)[mm] YPR140W Glycerophospholipid metabolism +r_2699 MLCL (2-18:1, 3-18:1, 4-16:1):PC (1-18:1, 2-18:1) acyltransferase, mitochondrial membrane monolysocardiolipin (2-18:1, 3-18:1, 4-16:1)[mm] + phosphatidylcholine (1-18:1, 2-18:1)[mm] <=> 1-acylglycerophosphocholine (18:1)[mm] + cardiolipin (1-18:1, 2-18:1, 3-18:1, 4-16:1)[mm] YPR140W Glycerophospholipid metabolism +r_2700 MLCL (2-18:1, 3-16:0, 4-18:1):PC (1-16:0, 2-16:1) acyltransferase, mitochondrial membrane monolysocardiolipin (2-18:1, 3-16:0, 4-18:1)[mm] + phosphatidylcholine (1-16:0, 2-16:1)[mm] <=> cardiolipin (1-16:1, 2-18:1, 3-16:0, 4-18:1)[mm] + 1-acylglycerophosphocholine (16:0)[mm] YPR140W Glycerophospholipid metabolism +r_2701 MLCL (2-18:1, 3-16:0, 4-18:1):PC (1-16:1, 2-16:1) acyltransferase, mitochondrial membrane monolysocardiolipin (2-18:1, 3-16:0, 4-18:1)[mm] + phosphatidylcholine (1-16:1, 2-16:1)[mm] <=> cardiolipin (1-16:1, 2-18:1, 3-16:0, 4-18:1)[mm] + 1-acylglycerophosphocholine (16:1)[mm] YPR140W Glycerophospholipid metabolism +r_2702 MLCL (2-18:1, 3-16:0, 4-18:1):PC (1-18:0, 2-16:1) acyltransferase, mitochondrial membrane monolysocardiolipin (2-18:1, 3-16:0, 4-18:1)[mm] + phosphatidylcholine (1-18:0, 2-16:1)[mm] <=> cardiolipin (1-16:1, 2-18:1, 3-16:0, 4-18:1)[mm] + 1-acylglycerophosphocholine (18:0)[mm] YPR140W Glycerophospholipid metabolism +r_2703 MLCL (2-18:1, 3-16:0, 4-18:1):PC (1-18:1, 2-16:1) acyltransferase, mitochondrial membrane monolysocardiolipin (2-18:1, 3-16:0, 4-18:1)[mm] + phosphatidylcholine (1-18:1, 2-16:1)[mm] <=> cardiolipin (1-16:1, 2-18:1, 3-16:0, 4-18:1)[mm] + 1-acylglycerophosphocholine (18:1)[mm] YPR140W Glycerophospholipid metabolism +r_2704 MLCL (2-18:1, 3-16:0, 4-18:1):PC (1-16:0, 2-18:1) acyltransferase, mitochondrial membrane monolysocardiolipin (2-18:1, 3-16:0, 4-18:1)[mm] + phosphatidylcholine (1-16:0, 2-18:1)[mm] <=> 1-acylglycerophosphocholine (16:0)[mm] + cardiolipin (1-18:1, 2-18:1, 3-16:0, 4-18:1)[mm] YPR140W Glycerophospholipid metabolism +r_2705 MLCL (2-18:1, 3-16:0, 4-18:1):PC (1-16:1, 2-18:1) acyltransferase, mitochondrial membrane monolysocardiolipin (2-18:1, 3-16:0, 4-18:1)[mm] + phosphatidylcholine (1-16:1, 2-18:1)[mm] <=> 1-acylglycerophosphocholine (16:1)[mm] + cardiolipin (1-18:1, 2-18:1, 3-16:0, 4-18:1)[mm] YPR140W Glycerophospholipid metabolism +r_2706 MLCL (2-18:1, 3-16:0, 4-18:1):PC (1-18:0, 2-18:1) acyltransferase, mitochondrial membrane monolysocardiolipin (2-18:1, 3-16:0, 4-18:1)[mm] + phosphatidylcholine (1-18:0, 2-18:1)[mm] <=> 1-acylglycerophosphocholine (18:0)[mm] + cardiolipin (1-18:1, 2-18:1, 3-16:0, 4-18:1)[mm] YPR140W Glycerophospholipid metabolism +r_2707 MLCL (2-18:1, 3-16:0, 4-18:1):PC (1-18:1, 2-18:1) acyltransferase, mitochondrial membrane monolysocardiolipin (2-18:1, 3-16:0, 4-18:1)[mm] + phosphatidylcholine (1-18:1, 2-18:1)[mm] <=> 1-acylglycerophosphocholine (18:1)[mm] + cardiolipin (1-18:1, 2-18:1, 3-16:0, 4-18:1)[mm] YPR140W Glycerophospholipid metabolism +r_2708 MLCL (2-18:1, 3-16:1, 4-18:1):PC (1-16:0, 2-16:1) acyltransferase, mitochondrial membrane monolysocardiolipin (2-18:1, 3-16:1, 4-18:1)[mm] + phosphatidylcholine (1-16:0, 2-16:1)[mm] <=> cardiolipin (1-16:1, 2-18:1, 3-16:1, 4-18:1)[mm] + 1-acylglycerophosphocholine (16:0)[mm] YPR140W Glycerophospholipid metabolism +r_2709 MLCL (2-18:1, 3-16:1, 4-18:1):PC (1-16:1, 2-16:1) acyltransferase, mitochondrial membrane monolysocardiolipin (2-18:1, 3-16:1, 4-18:1)[mm] + phosphatidylcholine (1-16:1, 2-16:1)[mm] <=> cardiolipin (1-16:1, 2-18:1, 3-16:1, 4-18:1)[mm] + 1-acylglycerophosphocholine (16:1)[mm] YPR140W Glycerophospholipid metabolism +r_2710 MLCL (2-18:1, 3-16:1, 4-18:1):PC (1-18:0, 2-16:1) acyltransferase, mitochondrial membrane monolysocardiolipin (2-18:1, 3-16:1, 4-18:1)[mm] + phosphatidylcholine (1-18:0, 2-16:1)[mm] <=> cardiolipin (1-16:1, 2-18:1, 3-16:1, 4-18:1)[mm] + 1-acylglycerophosphocholine (18:0)[mm] YPR140W Glycerophospholipid metabolism +r_2711 MLCL (2-18:1, 3-16:1, 4-18:1):PC (1-18:1, 2-16:1) acyltransferase, mitochondrial membrane monolysocardiolipin (2-18:1, 3-16:1, 4-18:1)[mm] + phosphatidylcholine (1-18:1, 2-16:1)[mm] <=> cardiolipin (1-16:1, 2-18:1, 3-16:1, 4-18:1)[mm] + 1-acylglycerophosphocholine (18:1)[mm] YPR140W Glycerophospholipid metabolism +r_2712 MLCL (2-18:1, 3-16:1, 4-18:1):PC (1-16:0, 2-18:1) acyltransferase, mitochondrial membrane monolysocardiolipin (2-18:1, 3-16:1, 4-18:1)[mm] + phosphatidylcholine (1-16:0, 2-18:1)[mm] <=> 1-acylglycerophosphocholine (16:0)[mm] + cardiolipin (1-18:1, 2-18:1, 3-16:1, 4-18:1)[mm] YPR140W Glycerophospholipid metabolism +r_2713 MLCL (2-18:1, 3-16:1, 4-18:1):PC (1-16:1, 2-18:1) acyltransferase, mitochondrial membrane monolysocardiolipin (2-18:1, 3-16:1, 4-18:1)[mm] + phosphatidylcholine (1-16:1, 2-18:1)[mm] <=> 1-acylglycerophosphocholine (16:1)[mm] + cardiolipin (1-18:1, 2-18:1, 3-16:1, 4-18:1)[mm] YPR140W Glycerophospholipid metabolism +r_2714 MLCL (2-18:1, 3-16:1, 4-18:1):PC (1-18:0, 2-18:1) acyltransferase, mitochondrial membrane monolysocardiolipin (2-18:1, 3-16:1, 4-18:1)[mm] + phosphatidylcholine (1-18:0, 2-18:1)[mm] <=> 1-acylglycerophosphocholine (18:0)[mm] + cardiolipin (1-18:1, 2-18:1, 3-16:1, 4-18:1)[mm] YPR140W Glycerophospholipid metabolism +r_2715 MLCL (2-18:1, 3-16:1, 4-18:1):PC (1-18:1, 2-18:1) acyltransferase, mitochondrial membrane monolysocardiolipin (2-18:1, 3-16:1, 4-18:1)[mm] + phosphatidylcholine (1-18:1, 2-18:1)[mm] <=> 1-acylglycerophosphocholine (18:1)[mm] + cardiolipin (1-18:1, 2-18:1, 3-16:1, 4-18:1)[mm] YPR140W Glycerophospholipid metabolism +r_2716 MLCL (1-16:0, 2-16:1, 4-16:1):PC (1-16:0, 2-16:1) acyltransferase, mitochondrial membrane monolysocardiolipin (1-16:0, 2-16:1, 4-16:1)[mm] + phosphatidylcholine (1-16:0, 2-16:1)[mm] <=> cardiolipin (1-16:0, 2-16:1, 3-16:1, 4-16:1)[mm] + 1-acylglycerophosphocholine (16:0)[mm] YPR140W Glycerophospholipid metabolism +r_2717 MLCL (1-16:0, 2-16:1, 4-16:1):PC (1-16:1, 2-16:1) acyltransferase, mitochondrial membrane monolysocardiolipin (1-16:0, 2-16:1, 4-16:1)[mm] + phosphatidylcholine (1-16:1, 2-16:1)[mm] <=> cardiolipin (1-16:0, 2-16:1, 3-16:1, 4-16:1)[mm] + 1-acylglycerophosphocholine (16:1)[mm] YPR140W Glycerophospholipid metabolism +r_2718 MLCL (1-16:0, 2-16:1, 4-16:1):PC (1-18:0, 2-16:1) acyltransferase, mitochondrial membrane monolysocardiolipin (1-16:0, 2-16:1, 4-16:1)[mm] + phosphatidylcholine (1-18:0, 2-16:1)[mm] <=> cardiolipin (1-16:0, 2-16:1, 3-16:1, 4-16:1)[mm] + 1-acylglycerophosphocholine (18:0)[mm] YPR140W Glycerophospholipid metabolism +r_2719 MLCL (1-16:0, 2-16:1, 4-16:1):PC (1-18:1, 2-16:1) acyltransferase, mitochondrial membrane monolysocardiolipin (1-16:0, 2-16:1, 4-16:1)[mm] + phosphatidylcholine (1-18:1, 2-16:1)[mm] <=> cardiolipin (1-16:0, 2-16:1, 3-16:1, 4-16:1)[mm] + 1-acylglycerophosphocholine (18:1)[mm] YPR140W Glycerophospholipid metabolism +r_2720 MLCL (1-16:0, 2-16:1, 4-16:1):PC (1-16:0, 2-18:1) acyltransferase, mitochondrial membrane monolysocardiolipin (1-16:0, 2-16:1, 4-16:1)[mm] + phosphatidylcholine (1-16:0, 2-18:1)[mm] <=> cardiolipin (1-16:0, 2-16:1, 3-18:1, 4-16:1)[mm] + 1-acylglycerophosphocholine (16:0)[mm] YPR140W Glycerophospholipid metabolism +r_2721 MLCL (1-16:0, 2-16:1, 4-16:1):PC (1-16:1, 2-18:1) acyltransferase, mitochondrial membrane monolysocardiolipin (1-16:0, 2-16:1, 4-16:1)[mm] + phosphatidylcholine (1-16:1, 2-18:1)[mm] <=> cardiolipin (1-16:0, 2-16:1, 3-18:1, 4-16:1)[mm] + 1-acylglycerophosphocholine (16:1)[mm] YPR140W Glycerophospholipid metabolism +r_2722 MLCL (1-16:0, 2-16:1, 4-16:1):PC (1-18:0, 2-18:1) acyltransferase, mitochondrial membrane monolysocardiolipin (1-16:0, 2-16:1, 4-16:1)[mm] + phosphatidylcholine (1-18:0, 2-18:1)[mm] <=> cardiolipin (1-16:0, 2-16:1, 3-18:1, 4-16:1)[mm] + 1-acylglycerophosphocholine (18:0)[mm] YPR140W Glycerophospholipid metabolism +r_2723 MLCL (1-16:0, 2-16:1, 4-16:1):PC (1-18:1, 2-18:1) acyltransferase, mitochondrial membrane monolysocardiolipin (1-16:0, 2-16:1, 4-16:1)[mm] + phosphatidylcholine (1-18:1, 2-18:1)[mm] <=> cardiolipin (1-16:0, 2-16:1, 3-18:1, 4-16:1)[mm] + 1-acylglycerophosphocholine (18:1)[mm] YPR140W Glycerophospholipid metabolism +r_2724 MLCL (1-16:0, 2-16:1, 4-18:1):PC (1-16:0, 2-16:1) acyltransferase, mitochondrial membrane monolysocardiolipin (1-16:0, 2-16:1, 4-18:1)[mm] + phosphatidylcholine (1-16:0, 2-16:1)[mm] <=> cardiolipin (1-16:0, 2-16:1, 3-16:1, 4-18:1)[mm] + 1-acylglycerophosphocholine (16:0)[mm] YPR140W Glycerophospholipid metabolism +r_2725 MLCL (1-16:0, 2-16:1, 4-18:1):PC (1-16:1, 2-16:1) acyltransferase, mitochondrial membrane monolysocardiolipin (1-16:0, 2-16:1, 4-18:1)[mm] + phosphatidylcholine (1-16:1, 2-16:1)[mm] <=> cardiolipin (1-16:0, 2-16:1, 3-16:1, 4-18:1)[mm] + 1-acylglycerophosphocholine (16:1)[mm] YPR140W Glycerophospholipid metabolism +r_2726 MLCL (1-16:0, 2-16:1, 4-18:1):PC (1-18:0, 2-16:1) acyltransferase, mitochondrial membrane monolysocardiolipin (1-16:0, 2-16:1, 4-18:1)[mm] + phosphatidylcholine (1-18:0, 2-16:1)[mm] <=> cardiolipin (1-16:0, 2-16:1, 3-16:1, 4-18:1)[mm] + 1-acylglycerophosphocholine (18:0)[mm] YPR140W Glycerophospholipid metabolism +r_2727 MLCL (1-16:0, 2-16:1, 4-18:1):PC (1-18:1, 2-16:1) acyltransferase, mitochondrial membrane monolysocardiolipin (1-16:0, 2-16:1, 4-18:1)[mm] + phosphatidylcholine (1-18:1, 2-16:1)[mm] <=> cardiolipin (1-16:0, 2-16:1, 3-16:1, 4-18:1)[mm] + 1-acylglycerophosphocholine (18:1)[mm] YPR140W Glycerophospholipid metabolism +r_2728 MLCL (1-16:0, 2-16:1, 4-18:1):PC (1-16:0, 2-18:1) acyltransferase, mitochondrial membrane monolysocardiolipin (1-16:0, 2-16:1, 4-18:1)[mm] + phosphatidylcholine (1-16:0, 2-18:1)[mm] <=> 1-acylglycerophosphocholine (16:0)[mm] + cardiolipin (1-16:0, 2-16:1, 3-18:1, 4-18:1)[mm] YPR140W Glycerophospholipid metabolism +r_2729 MLCL (1-16:0, 2-16:1, 4-18:1):PC (1-16:1, 2-18:1) acyltransferase, mitochondrial membrane monolysocardiolipin (1-16:0, 2-16:1, 4-18:1)[mm] + phosphatidylcholine (1-16:1, 2-18:1)[mm] <=> 1-acylglycerophosphocholine (16:1)[mm] + cardiolipin (1-16:0, 2-16:1, 3-18:1, 4-18:1)[mm] YPR140W Glycerophospholipid metabolism +r_2730 MLCL (1-16:0, 2-16:1, 4-18:1):PC (1-18:0, 2-18:1) acyltransferase, mitochondrial membrane monolysocardiolipin (1-16:0, 2-16:1, 4-18:1)[mm] + phosphatidylcholine (1-18:0, 2-18:1)[mm] <=> 1-acylglycerophosphocholine (18:0)[mm] + cardiolipin (1-16:0, 2-16:1, 3-18:1, 4-18:1)[mm] YPR140W Glycerophospholipid metabolism +r_2731 MLCL (1-16:0, 2-16:1, 4-18:1):PC (1-18:1, 2-18:1) acyltransferase, mitochondrial membrane monolysocardiolipin (1-16:0, 2-16:1, 4-18:1)[mm] + phosphatidylcholine (1-18:1, 2-18:1)[mm] <=> 1-acylglycerophosphocholine (18:1)[mm] + cardiolipin (1-16:0, 2-16:1, 3-18:1, 4-18:1)[mm] YPR140W Glycerophospholipid metabolism +r_2732 MLCL (1-16:1, 2-16:1, 4-16:1):PC (1-16:0, 2-16:1) acyltransferase, mitochondrial membrane monolysocardiolipin (1-16:1, 2-16:1, 4-16:1)[mm] + phosphatidylcholine (1-16:0, 2-16:1)[mm] <=> cardiolipin (1-16:1, 2-16:1, 3-16:1, 4-16:1)[mm] + 1-acylglycerophosphocholine (16:0)[mm] YPR140W Glycerophospholipid metabolism +r_2733 MLCL (1-16:1, 2-16:1, 4-16:1):PC (1-16:1, 2-16:1) acyltransferase, mitochondrial membrane monolysocardiolipin (1-16:1, 2-16:1, 4-16:1)[mm] + phosphatidylcholine (1-16:1, 2-16:1)[mm] <=> cardiolipin (1-16:1, 2-16:1, 3-16:1, 4-16:1)[mm] + 1-acylglycerophosphocholine (16:1)[mm] YPR140W Glycerophospholipid metabolism +r_2734 MLCL (1-16:1, 2-16:1, 4-16:1):PC (1-18:0, 2-16:1) acyltransferase, mitochondrial membrane monolysocardiolipin (1-16:1, 2-16:1, 4-16:1)[mm] + phosphatidylcholine (1-18:0, 2-16:1)[mm] <=> cardiolipin (1-16:1, 2-16:1, 3-16:1, 4-16:1)[mm] + 1-acylglycerophosphocholine (18:0)[mm] YPR140W Glycerophospholipid metabolism +r_2735 MLCL (1-16:1, 2-16:1, 4-16:1):PC (1-18:1, 2-16:1) acyltransferase, mitochondrial membrane monolysocardiolipin (1-16:1, 2-16:1, 4-16:1)[mm] + phosphatidylcholine (1-18:1, 2-16:1)[mm] <=> cardiolipin (1-16:1, 2-16:1, 3-16:1, 4-16:1)[mm] + 1-acylglycerophosphocholine (18:1)[mm] YPR140W Glycerophospholipid metabolism +r_2736 MLCL (1-16:1, 2-16:1, 4-16:1):PC (1-16:0, 2-18:1) acyltransferase, mitochondrial membrane monolysocardiolipin (1-16:1, 2-16:1, 4-16:1)[mm] + phosphatidylcholine (1-16:0, 2-18:1)[mm] <=> cardiolipin (1-16:1, 2-16:1, 3-18:1, 4-16:1)[mm] + 1-acylglycerophosphocholine (16:0)[mm] YPR140W Glycerophospholipid metabolism +r_2737 MLCL (1-16:1, 2-16:1, 4-16:1):PC (1-16:1, 2-18:1) acyltransferase, mitochondrial membrane monolysocardiolipin (1-16:1, 2-16:1, 4-16:1)[mm] + phosphatidylcholine (1-16:1, 2-18:1)[mm] <=> cardiolipin (1-16:1, 2-16:1, 3-18:1, 4-16:1)[mm] + 1-acylglycerophosphocholine (16:1)[mm] YPR140W Glycerophospholipid metabolism +r_2738 MLCL (1-16:1, 2-16:1, 4-16:1):PC (1-18:0, 2-18:1) acyltransferase, mitochondrial membrane monolysocardiolipin (1-16:1, 2-16:1, 4-16:1)[mm] + phosphatidylcholine (1-18:0, 2-18:1)[mm] <=> cardiolipin (1-16:1, 2-16:1, 3-18:1, 4-16:1)[mm] + 1-acylglycerophosphocholine (18:0)[mm] YPR140W Glycerophospholipid metabolism +r_2739 MLCL (1-16:1, 2-16:1, 4-16:1):PC (1-18:1, 2-18:1) acyltransferase, mitochondrial membrane monolysocardiolipin (1-16:1, 2-16:1, 4-16:1)[mm] + phosphatidylcholine (1-18:1, 2-18:1)[mm] <=> cardiolipin (1-16:1, 2-16:1, 3-18:1, 4-16:1)[mm] + 1-acylglycerophosphocholine (18:1)[mm] YPR140W Glycerophospholipid metabolism +r_2740 MLCL (1-16:1, 2-16:1, 4-18:1):PC (1-16:0, 2-16:1) acyltransferase, mitochondrial membrane monolysocardiolipin (1-16:1, 2-16:1, 4-18:1)[mm] + phosphatidylcholine (1-16:0, 2-16:1)[mm] <=> cardiolipin (1-16:1, 2-16:1, 3-16:1, 4-18:1)[mm] + 1-acylglycerophosphocholine (16:0)[mm] YPR140W Glycerophospholipid metabolism +r_2741 MLCL (1-16:1, 2-16:1, 4-18:1):PC (1-16:1, 2-16:1) acyltransferase, mitochondrial membrane monolysocardiolipin (1-16:1, 2-16:1, 4-18:1)[mm] + phosphatidylcholine (1-16:1, 2-16:1)[mm] <=> cardiolipin (1-16:1, 2-16:1, 3-16:1, 4-18:1)[mm] + 1-acylglycerophosphocholine (16:1)[mm] YPR140W Glycerophospholipid metabolism +r_2742 MLCL (1-16:1, 2-16:1, 4-18:1):PC (1-18:0, 2-16:1) acyltransferase, mitochondrial membrane monolysocardiolipin (1-16:1, 2-16:1, 4-18:1)[mm] + phosphatidylcholine (1-18:0, 2-16:1)[mm] <=> cardiolipin (1-16:1, 2-16:1, 3-16:1, 4-18:1)[mm] + 1-acylglycerophosphocholine (18:0)[mm] YPR140W Glycerophospholipid metabolism +r_2743 MLCL (1-16:1, 2-16:1, 4-18:1):PC (1-18:1, 2-16:1) acyltransferase, mitochondrial membrane monolysocardiolipin (1-16:1, 2-16:1, 4-18:1)[mm] + phosphatidylcholine (1-18:1, 2-16:1)[mm] <=> cardiolipin (1-16:1, 2-16:1, 3-16:1, 4-18:1)[mm] + 1-acylglycerophosphocholine (18:1)[mm] YPR140W Glycerophospholipid metabolism +r_2744 MLCL (1-16:1, 2-16:1, 4-18:1):PC (1-16:0, 2-18:1) acyltransferase, mitochondrial membrane monolysocardiolipin (1-16:1, 2-16:1, 4-18:1)[mm] + phosphatidylcholine (1-16:0, 2-18:1)[mm] <=> 1-acylglycerophosphocholine (16:0)[mm] + cardiolipin (1-16:1, 2-16:1, 3-18:1, 4-18:1)[mm] YPR140W Glycerophospholipid metabolism +r_2745 MLCL (1-16:1, 2-16:1, 4-18:1):PC (1-16:1, 2-18:1) acyltransferase, mitochondrial membrane monolysocardiolipin (1-16:1, 2-16:1, 4-18:1)[mm] + phosphatidylcholine (1-16:1, 2-18:1)[mm] <=> 1-acylglycerophosphocholine (16:1)[mm] + cardiolipin (1-16:1, 2-16:1, 3-18:1, 4-18:1)[mm] YPR140W Glycerophospholipid metabolism +r_2746 MLCL (1-16:1, 2-16:1, 4-18:1):PC (1-18:0, 2-18:1) acyltransferase, mitochondrial membrane monolysocardiolipin (1-16:1, 2-16:1, 4-18:1)[mm] + phosphatidylcholine (1-18:0, 2-18:1)[mm] <=> 1-acylglycerophosphocholine (18:0)[mm] + cardiolipin (1-16:1, 2-16:1, 3-18:1, 4-18:1)[mm] YPR140W Glycerophospholipid metabolism +r_2747 MLCL (1-16:1, 2-16:1, 4-18:1):PC (1-18:1, 2-18:1) acyltransferase, mitochondrial membrane monolysocardiolipin (1-16:1, 2-16:1, 4-18:1)[mm] + phosphatidylcholine (1-18:1, 2-18:1)[mm] <=> 1-acylglycerophosphocholine (18:1)[mm] + cardiolipin (1-16:1, 2-16:1, 3-18:1, 4-18:1)[mm] YPR140W Glycerophospholipid metabolism +r_2748 MLCL (1-18:0, 2-16:1, 4-16:1):PC (1-16:0, 2-16:1) acyltransferase, mitochondrial membrane monolysocardiolipin (1-18:0, 2-16:1, 4-16:1)[mm] + phosphatidylcholine (1-16:0, 2-16:1)[mm] <=> cardiolipin (1-18:0, 2-16:1, 3-16:1, 4-16:1)[mm] + 1-acylglycerophosphocholine (16:0)[mm] YPR140W Glycerophospholipid metabolism +r_2749 MLCL (1-18:0, 2-16:1, 4-16:1):PC (1-16:1, 2-16:1) acyltransferase, mitochondrial membrane monolysocardiolipin (1-18:0, 2-16:1, 4-16:1)[mm] + phosphatidylcholine (1-16:1, 2-16:1)[mm] <=> cardiolipin (1-18:0, 2-16:1, 3-16:1, 4-16:1)[mm] + 1-acylglycerophosphocholine (16:1)[mm] YPR140W Glycerophospholipid metabolism +r_2750 MLCL (1-18:0, 2-16:1, 4-16:1):PC (1-18:0, 2-16:1) acyltransferase, mitochondrial membrane monolysocardiolipin (1-18:0, 2-16:1, 4-16:1)[mm] + phosphatidylcholine (1-18:0, 2-16:1)[mm] <=> cardiolipin (1-18:0, 2-16:1, 3-16:1, 4-16:1)[mm] + 1-acylglycerophosphocholine (18:0)[mm] YPR140W Glycerophospholipid metabolism +r_2751 MLCL (1-18:0, 2-16:1, 4-16:1):PC (1-18:1, 2-16:1) acyltransferase, mitochondrial membrane monolysocardiolipin (1-18:0, 2-16:1, 4-16:1)[mm] + phosphatidylcholine (1-18:1, 2-16:1)[mm] <=> cardiolipin (1-18:0, 2-16:1, 3-16:1, 4-16:1)[mm] + 1-acylglycerophosphocholine (18:1)[mm] YPR140W Glycerophospholipid metabolism +r_2752 MLCL (1-18:0, 2-16:1, 4-16:1):PC (1-16:0, 2-18:1) acyltransferase, mitochondrial membrane monolysocardiolipin (1-18:0, 2-16:1, 4-16:1)[mm] + phosphatidylcholine (1-16:0, 2-18:1)[mm] <=> cardiolipin (1-18:0, 2-16:1, 3-18:1, 4-16:1)[mm] + 1-acylglycerophosphocholine (16:0)[mm] YPR140W Glycerophospholipid metabolism +r_2753 MLCL (1-18:0, 2-16:1, 4-16:1):PC (1-16:1, 2-18:1) acyltransferase, mitochondrial membrane monolysocardiolipin (1-18:0, 2-16:1, 4-16:1)[mm] + phosphatidylcholine (1-16:1, 2-18:1)[mm] <=> cardiolipin (1-18:0, 2-16:1, 3-18:1, 4-16:1)[mm] + 1-acylglycerophosphocholine (16:1)[mm] YPR140W Glycerophospholipid metabolism +r_2754 MLCL (1-18:0, 2-16:1, 4-16:1):PC (1-18:0, 2-18:1) acyltransferase, mitochondrial membrane monolysocardiolipin (1-18:0, 2-16:1, 4-16:1)[mm] + phosphatidylcholine (1-18:0, 2-18:1)[mm] <=> cardiolipin (1-18:0, 2-16:1, 3-18:1, 4-16:1)[mm] + 1-acylglycerophosphocholine (18:0)[mm] YPR140W Glycerophospholipid metabolism +r_2755 MLCL (1-18:0, 2-16:1, 4-16:1):PC (1-18:1, 2-18:1) acyltransferase, mitochondrial membrane monolysocardiolipin (1-18:0, 2-16:1, 4-16:1)[mm] + phosphatidylcholine (1-18:1, 2-18:1)[mm] <=> cardiolipin (1-18:0, 2-16:1, 3-18:1, 4-16:1)[mm] + 1-acylglycerophosphocholine (18:1)[mm] YPR140W Glycerophospholipid metabolism +r_2756 MLCL (1-18:0, 2-16:1, 4-18:1):PC (1-16:0, 2-16:1) acyltransferase, mitochondrial membrane monolysocardiolipin (1-18:0, 2-16:1, 4-18:1)[mm] + phosphatidylcholine (1-16:0, 2-16:1)[mm] <=> cardiolipin (1-18:0, 2-16:1, 3-16:1, 4-18:1)[mm] + 1-acylglycerophosphocholine (16:0)[mm] YPR140W Glycerophospholipid metabolism +r_2757 MLCL (1-18:0, 2-16:1, 4-18:1):PC (1-16:1, 2-16:1) acyltransferase, mitochondrial membrane monolysocardiolipin (1-18:0, 2-16:1, 4-18:1)[mm] + phosphatidylcholine (1-16:1, 2-16:1)[mm] <=> cardiolipin (1-18:0, 2-16:1, 3-16:1, 4-18:1)[mm] + 1-acylglycerophosphocholine (16:1)[mm] YPR140W Glycerophospholipid metabolism +r_2758 MLCL (1-18:0, 2-16:1, 4-18:1):PC (1-18:0, 2-16:1) acyltransferase, mitochondrial membrane monolysocardiolipin (1-18:0, 2-16:1, 4-18:1)[mm] + phosphatidylcholine (1-18:0, 2-16:1)[mm] <=> cardiolipin (1-18:0, 2-16:1, 3-16:1, 4-18:1)[mm] + 1-acylglycerophosphocholine (18:0)[mm] YPR140W Glycerophospholipid metabolism +r_2759 MLCL (1-18:0, 2-16:1, 4-18:1):PC (1-18:1, 2-16:1) acyltransferase, mitochondrial membrane monolysocardiolipin (1-18:0, 2-16:1, 4-18:1)[mm] + phosphatidylcholine (1-18:1, 2-16:1)[mm] <=> cardiolipin (1-18:0, 2-16:1, 3-16:1, 4-18:1)[mm] + 1-acylglycerophosphocholine (18:1)[mm] YPR140W Glycerophospholipid metabolism +r_2760 MLCL (1-18:0, 2-16:1, 4-18:1):PC (1-16:0, 2-18:1) acyltransferase, mitochondrial membrane monolysocardiolipin (1-18:0, 2-16:1, 4-18:1)[mm] + phosphatidylcholine (1-16:0, 2-18:1)[mm] <=> 1-acylglycerophosphocholine (16:0)[mm] + cardiolipin (1-18:0, 2-16:1, 3-18:1, 4-18:1)[mm] YPR140W Glycerophospholipid metabolism +r_2761 MLCL (1-18:0, 2-16:1, 4-18:1):PC (1-16:1, 2-18:1) acyltransferase, mitochondrial membrane monolysocardiolipin (1-18:0, 2-16:1, 4-18:1)[mm] + phosphatidylcholine (1-16:1, 2-18:1)[mm] <=> 1-acylglycerophosphocholine (16:1)[mm] + cardiolipin (1-18:0, 2-16:1, 3-18:1, 4-18:1)[mm] YPR140W Glycerophospholipid metabolism +r_2762 MLCL (1-18:0, 2-16:1, 4-18:1):PC (1-18:0, 2-18:1) acyltransferase, mitochondrial membrane monolysocardiolipin (1-18:0, 2-16:1, 4-18:1)[mm] + phosphatidylcholine (1-18:0, 2-18:1)[mm] <=> 1-acylglycerophosphocholine (18:0)[mm] + cardiolipin (1-18:0, 2-16:1, 3-18:1, 4-18:1)[mm] YPR140W Glycerophospholipid metabolism +r_2763 MLCL (1-18:0, 2-16:1, 4-18:1):PC (1-18:1, 2-18:1) acyltransferase, mitochondrial membrane monolysocardiolipin (1-18:0, 2-16:1, 4-18:1)[mm] + phosphatidylcholine (1-18:1, 2-18:1)[mm] <=> 1-acylglycerophosphocholine (18:1)[mm] + cardiolipin (1-18:0, 2-16:1, 3-18:1, 4-18:1)[mm] YPR140W Glycerophospholipid metabolism +r_2764 MLCL (1-18:1, 2-16:1, 4-16:1):PC (1-16:0, 2-16:1) acyltransferase, mitochondrial membrane monolysocardiolipin (1-18:1, 2-16:1, 4-16:1)[mm] + phosphatidylcholine (1-16:0, 2-16:1)[mm] <=> cardiolipin (1-18:1, 2-16:1, 3-16:1, 4-16:1)[mm] + 1-acylglycerophosphocholine (16:0)[mm] YPR140W Glycerophospholipid metabolism +r_2765 MLCL (1-18:1, 2-16:1, 4-16:1):PC (1-16:1, 2-16:1) acyltransferase, mitochondrial membrane monolysocardiolipin (1-18:1, 2-16:1, 4-16:1)[mm] + phosphatidylcholine (1-16:1, 2-16:1)[mm] <=> cardiolipin (1-18:1, 2-16:1, 3-16:1, 4-16:1)[mm] + 1-acylglycerophosphocholine (16:1)[mm] YPR140W Glycerophospholipid metabolism +r_2766 MLCL (1-18:1, 2-16:1, 4-16:1):PC (1-18:0, 2-16:1) acyltransferase, mitochondrial membrane monolysocardiolipin (1-18:1, 2-16:1, 4-16:1)[mm] + phosphatidylcholine (1-18:0, 2-16:1)[mm] <=> cardiolipin (1-18:1, 2-16:1, 3-16:1, 4-16:1)[mm] + 1-acylglycerophosphocholine (18:0)[mm] YPR140W Glycerophospholipid metabolism +r_2767 MLCL (1-18:1, 2-16:1, 4-16:1):PC (1-18:1, 2-16:1) acyltransferase, mitochondrial membrane monolysocardiolipin (1-18:1, 2-16:1, 4-16:1)[mm] + phosphatidylcholine (1-18:1, 2-16:1)[mm] <=> cardiolipin (1-18:1, 2-16:1, 3-16:1, 4-16:1)[mm] + 1-acylglycerophosphocholine (18:1)[mm] YPR140W Glycerophospholipid metabolism +r_2768 MLCL (1-18:1, 2-16:1, 4-16:1):PC (1-16:0, 2-18:1) acyltransferase, mitochondrial membrane monolysocardiolipin (1-18:1, 2-16:1, 4-16:1)[mm] + phosphatidylcholine (1-16:0, 2-18:1)[mm] <=> cardiolipin (1-18:1, 2-16:1, 3-18:1, 4-16:1)[mm] + 1-acylglycerophosphocholine (16:0)[mm] YPR140W Glycerophospholipid metabolism +r_2769 MLCL (1-18:1, 2-16:1, 4-16:1):PC (1-16:1, 2-18:1) acyltransferase, mitochondrial membrane monolysocardiolipin (1-18:1, 2-16:1, 4-16:1)[mm] + phosphatidylcholine (1-16:1, 2-18:1)[mm] <=> cardiolipin (1-18:1, 2-16:1, 3-18:1, 4-16:1)[mm] + 1-acylglycerophosphocholine (16:1)[mm] YPR140W Glycerophospholipid metabolism +r_2770 MLCL (1-18:1, 2-16:1, 4-16:1):PC (1-18:0, 2-18:1) acyltransferase, mitochondrial membrane monolysocardiolipin (1-18:1, 2-16:1, 4-16:1)[mm] + phosphatidylcholine (1-18:0, 2-18:1)[mm] <=> cardiolipin (1-18:1, 2-16:1, 3-18:1, 4-16:1)[mm] + 1-acylglycerophosphocholine (18:0)[mm] YPR140W Glycerophospholipid metabolism +r_2771 MLCL (1-18:1, 2-16:1, 4-16:1):PC (1-18:1, 2-18:1) acyltransferase, mitochondrial membrane monolysocardiolipin (1-18:1, 2-16:1, 4-16:1)[mm] + phosphatidylcholine (1-18:1, 2-18:1)[mm] <=> cardiolipin (1-18:1, 2-16:1, 3-18:1, 4-16:1)[mm] + 1-acylglycerophosphocholine (18:1)[mm] YPR140W Glycerophospholipid metabolism +r_2772 MLCL (1-18:1, 2-16:1, 4-18:1):PC (1-16:0, 2-16:1) acyltransferase, mitochondrial membrane monolysocardiolipin (1-18:1, 2-16:1, 4-18:1)[mm] + phosphatidylcholine (1-16:0, 2-16:1)[mm] <=> cardiolipin (1-18:1, 2-16:1, 3-16:1, 4-18:1)[mm] + 1-acylglycerophosphocholine (16:0)[mm] YPR140W Glycerophospholipid metabolism +r_2773 MLCL (1-18:1, 2-16:1, 4-18:1):PC (1-16:1, 2-16:1) acyltransferase, mitochondrial membrane monolysocardiolipin (1-18:1, 2-16:1, 4-18:1)[mm] + phosphatidylcholine (1-16:1, 2-16:1)[mm] <=> cardiolipin (1-18:1, 2-16:1, 3-16:1, 4-18:1)[mm] + 1-acylglycerophosphocholine (16:1)[mm] YPR140W Glycerophospholipid metabolism +r_2774 MLCL (1-18:1, 2-16:1, 4-18:1):PC (1-18:0, 2-16:1) acyltransferase, mitochondrial membrane monolysocardiolipin (1-18:1, 2-16:1, 4-18:1)[mm] + phosphatidylcholine (1-18:0, 2-16:1)[mm] <=> cardiolipin (1-18:1, 2-16:1, 3-16:1, 4-18:1)[mm] + 1-acylglycerophosphocholine (18:0)[mm] YPR140W Glycerophospholipid metabolism +r_2775 MLCL (1-18:1, 2-16:1, 4-18:1):PC (1-18:1, 2-16:1) acyltransferase, mitochondrial membrane monolysocardiolipin (1-18:1, 2-16:1, 4-18:1)[mm] + phosphatidylcholine (1-18:1, 2-16:1)[mm] <=> cardiolipin (1-18:1, 2-16:1, 3-16:1, 4-18:1)[mm] + 1-acylglycerophosphocholine (18:1)[mm] YPR140W Glycerophospholipid metabolism +r_2776 MLCL (1-18:1, 2-16:1, 4-18:1):PC (1-16:0, 2-18:1) acyltransferase, mitochondrial membrane monolysocardiolipin (1-18:1, 2-16:1, 4-18:1)[mm] + phosphatidylcholine (1-16:0, 2-18:1)[mm] <=> 1-acylglycerophosphocholine (16:0)[mm] + cardiolipin (1-18:1, 2-16:1, 3-18:1, 4-18:1)[mm] YPR140W Glycerophospholipid metabolism +r_2777 MLCL (1-18:1, 2-16:1, 4-18:1):PC (1-16:1, 2-18:1) acyltransferase, mitochondrial membrane monolysocardiolipin (1-18:1, 2-16:1, 4-18:1)[mm] + phosphatidylcholine (1-16:1, 2-18:1)[mm] <=> 1-acylglycerophosphocholine (16:1)[mm] + cardiolipin (1-18:1, 2-16:1, 3-18:1, 4-18:1)[mm] YPR140W Glycerophospholipid metabolism +r_2778 MLCL (1-18:1, 2-16:1, 4-18:1):PC (1-18:0, 2-18:1) acyltransferase, mitochondrial membrane monolysocardiolipin (1-18:1, 2-16:1, 4-18:1)[mm] + phosphatidylcholine (1-18:0, 2-18:1)[mm] <=> 1-acylglycerophosphocholine (18:0)[mm] + cardiolipin (1-18:1, 2-16:1, 3-18:1, 4-18:1)[mm] YPR140W Glycerophospholipid metabolism +r_2779 MLCL (1-18:1, 2-16:1, 4-18:1):PC (1-18:1, 2-18:1) acyltransferase, mitochondrial membrane monolysocardiolipin (1-18:1, 2-16:1, 4-18:1)[mm] + phosphatidylcholine (1-18:1, 2-18:1)[mm] <=> 1-acylglycerophosphocholine (18:1)[mm] + cardiolipin (1-18:1, 2-16:1, 3-18:1, 4-18:1)[mm] YPR140W Glycerophospholipid metabolism +r_2780 MLCL (1-16:0, 2-18:1, 4-16:1):PC (1-16:0, 2-16:1) acyltransferase, mitochondrial membrane monolysocardiolipin (1-16:0, 2-18:1, 4-16:1)[mm] + phosphatidylcholine (1-16:0, 2-16:1)[mm] <=> cardiolipin (1-16:0, 2-18:1, 3-16:1, 4-16:1)[mm] + 1-acylglycerophosphocholine (16:0)[mm] YPR140W Glycerophospholipid metabolism +r_2781 MLCL (1-16:0, 2-18:1, 4-16:1):PC (1-16:1, 2-16:1) acyltransferase, mitochondrial membrane monolysocardiolipin (1-16:0, 2-18:1, 4-16:1)[mm] + phosphatidylcholine (1-16:1, 2-16:1)[mm] <=> cardiolipin (1-16:0, 2-18:1, 3-16:1, 4-16:1)[mm] + 1-acylglycerophosphocholine (16:1)[mm] YPR140W Glycerophospholipid metabolism +r_2782 MLCL (1-16:0, 2-18:1, 4-16:1):PC (1-18:0, 2-16:1) acyltransferase, mitochondrial membrane monolysocardiolipin (1-16:0, 2-18:1, 4-16:1)[mm] + phosphatidylcholine (1-18:0, 2-16:1)[mm] <=> cardiolipin (1-16:0, 2-18:1, 3-16:1, 4-16:1)[mm] + 1-acylglycerophosphocholine (18:0)[mm] YPR140W Glycerophospholipid metabolism +r_2783 MLCL (1-16:0, 2-18:1, 4-16:1):PC (1-18:1, 2-16:1) acyltransferase, mitochondrial membrane monolysocardiolipin (1-16:0, 2-18:1, 4-16:1)[mm] + phosphatidylcholine (1-18:1, 2-16:1)[mm] <=> cardiolipin (1-16:0, 2-18:1, 3-16:1, 4-16:1)[mm] + 1-acylglycerophosphocholine (18:1)[mm] YPR140W Glycerophospholipid metabolism +r_2784 MLCL (1-16:0, 2-18:1, 4-16:1):PC (1-16:0, 2-18:1) acyltransferase, mitochondrial membrane monolysocardiolipin (1-16:0, 2-18:1, 4-16:1)[mm] + phosphatidylcholine (1-16:0, 2-18:1)[mm] <=> cardiolipin (1-16:0, 2-18:1, 3-18:1, 4-16:1)[mm] + 1-acylglycerophosphocholine (16:0)[mm] YPR140W Glycerophospholipid metabolism +r_2785 MLCL (1-16:0, 2-18:1, 4-16:1):PC (1-16:1, 2-18:1) acyltransferase, mitochondrial membrane monolysocardiolipin (1-16:0, 2-18:1, 4-16:1)[mm] + phosphatidylcholine (1-16:1, 2-18:1)[mm] <=> cardiolipin (1-16:0, 2-18:1, 3-18:1, 4-16:1)[mm] + 1-acylglycerophosphocholine (16:1)[mm] YPR140W Glycerophospholipid metabolism +r_2786 MLCL (1-16:0, 2-18:1, 4-16:1):PC (1-18:0, 2-18:1) acyltransferase, mitochondrial membrane monolysocardiolipin (1-16:0, 2-18:1, 4-16:1)[mm] + phosphatidylcholine (1-18:0, 2-18:1)[mm] <=> cardiolipin (1-16:0, 2-18:1, 3-18:1, 4-16:1)[mm] + 1-acylglycerophosphocholine (18:0)[mm] YPR140W Glycerophospholipid metabolism +r_2787 MLCL (1-16:0, 2-18:1, 4-16:1):PC (1-18:1, 2-18:1) acyltransferase, mitochondrial membrane monolysocardiolipin (1-16:0, 2-18:1, 4-16:1)[mm] + phosphatidylcholine (1-18:1, 2-18:1)[mm] <=> cardiolipin (1-16:0, 2-18:1, 3-18:1, 4-16:1)[mm] + 1-acylglycerophosphocholine (18:1)[mm] YPR140W Glycerophospholipid metabolism +r_2788 MLCL (1-16:0, 2-18:1, 4-18:1):PC (1-16:0, 2-16:1) acyltransferase, mitochondrial membrane monolysocardiolipin (1-16:0, 2-18:1, 4-18:1)[mm] + phosphatidylcholine (1-16:0, 2-16:1)[mm] <=> cardiolipin (1-16:0, 2-18:1, 3-16:1, 4-18:1)[mm] + 1-acylglycerophosphocholine (16:0)[mm] YPR140W Glycerophospholipid metabolism +r_2789 MLCL (1-16:0, 2-18:1, 4-18:1):PC (1-16:1, 2-16:1) acyltransferase, mitochondrial membrane monolysocardiolipin (1-16:0, 2-18:1, 4-18:1)[mm] + phosphatidylcholine (1-16:1, 2-16:1)[mm] <=> cardiolipin (1-16:0, 2-18:1, 3-16:1, 4-18:1)[mm] + 1-acylglycerophosphocholine (16:1)[mm] YPR140W Glycerophospholipid metabolism +r_2790 MLCL (1-16:0, 2-18:1, 4-18:1):PC (1-18:0, 2-16:1) acyltransferase, mitochondrial membrane monolysocardiolipin (1-16:0, 2-18:1, 4-18:1)[mm] + phosphatidylcholine (1-18:0, 2-16:1)[mm] <=> cardiolipin (1-16:0, 2-18:1, 3-16:1, 4-18:1)[mm] + 1-acylglycerophosphocholine (18:0)[mm] YPR140W Glycerophospholipid metabolism +r_2791 MLCL (1-16:0, 2-18:1, 4-18:1):PC (1-18:1, 2-16:1) acyltransferase, mitochondrial membrane monolysocardiolipin (1-16:0, 2-18:1, 4-18:1)[mm] + phosphatidylcholine (1-18:1, 2-16:1)[mm] <=> cardiolipin (1-16:0, 2-18:1, 3-16:1, 4-18:1)[mm] + 1-acylglycerophosphocholine (18:1)[mm] YPR140W Glycerophospholipid metabolism +r_2792 MLCL (1-16:0, 2-18:1, 4-18:1):PC (1-16:0, 2-18:1) acyltransferase, mitochondrial membrane monolysocardiolipin (1-16:0, 2-18:1, 4-18:1)[mm] + phosphatidylcholine (1-16:0, 2-18:1)[mm] <=> 1-acylglycerophosphocholine (16:0)[mm] + cardiolipin (1-16:0, 2-18:1, 3-18:1, 4-18:1)[mm] YPR140W Glycerophospholipid metabolism +r_2793 MLCL (1-16:0, 2-18:1, 4-18:1):PC (1-16:1, 2-18:1) acyltransferase, mitochondrial membrane monolysocardiolipin (1-16:0, 2-18:1, 4-18:1)[mm] + phosphatidylcholine (1-16:1, 2-18:1)[mm] <=> 1-acylglycerophosphocholine (16:1)[mm] + cardiolipin (1-16:0, 2-18:1, 3-18:1, 4-18:1)[mm] YPR140W Glycerophospholipid metabolism +r_2794 MLCL (1-16:0, 2-18:1, 4-18:1):PC (1-18:0, 2-18:1) acyltransferase, mitochondrial membrane monolysocardiolipin (1-16:0, 2-18:1, 4-18:1)[mm] + phosphatidylcholine (1-18:0, 2-18:1)[mm] <=> 1-acylglycerophosphocholine (18:0)[mm] + cardiolipin (1-16:0, 2-18:1, 3-18:1, 4-18:1)[mm] YPR140W Glycerophospholipid metabolism +r_2795 MLCL (1-16:0, 2-18:1, 4-18:1):PC (1-18:1, 2-18:1) acyltransferase, mitochondrial membrane monolysocardiolipin (1-16:0, 2-18:1, 4-18:1)[mm] + phosphatidylcholine (1-18:1, 2-18:1)[mm] <=> 1-acylglycerophosphocholine (18:1)[mm] + cardiolipin (1-16:0, 2-18:1, 3-18:1, 4-18:1)[mm] YPR140W Glycerophospholipid metabolism +r_2796 MLCL (1-16:1, 2-18:1, 4-16:1):PC (1-16:0, 2-16:1) acyltransferase, mitochondrial membrane monolysocardiolipin (1-16:1, 2-18:1, 4-16:1)[mm] + phosphatidylcholine (1-16:0, 2-16:1)[mm] <=> cardiolipin (1-16:1, 2-18:1, 3-16:1, 4-16:1)[mm] + 1-acylglycerophosphocholine (16:0)[mm] YPR140W Glycerophospholipid metabolism +r_2797 MLCL (1-16:1, 2-18:1, 4-16:1):PC (1-16:1, 2-16:1) acyltransferase, mitochondrial membrane monolysocardiolipin (1-16:1, 2-18:1, 4-16:1)[mm] + phosphatidylcholine (1-16:1, 2-16:1)[mm] <=> cardiolipin (1-16:1, 2-18:1, 3-16:1, 4-16:1)[mm] + 1-acylglycerophosphocholine (16:1)[mm] YPR140W Glycerophospholipid metabolism +r_2798 MLCL (1-16:1, 2-18:1, 4-16:1):PC (1-18:0, 2-16:1) acyltransferase, mitochondrial membrane monolysocardiolipin (1-16:1, 2-18:1, 4-16:1)[mm] + phosphatidylcholine (1-18:0, 2-16:1)[mm] <=> cardiolipin (1-16:1, 2-18:1, 3-16:1, 4-16:1)[mm] + 1-acylglycerophosphocholine (18:0)[mm] YPR140W Glycerophospholipid metabolism +r_2799 MLCL (1-16:1, 2-18:1, 4-16:1):PC (1-18:1, 2-16:1) acyltransferase, mitochondrial membrane monolysocardiolipin (1-16:1, 2-18:1, 4-16:1)[mm] + phosphatidylcholine (1-18:1, 2-16:1)[mm] <=> cardiolipin (1-16:1, 2-18:1, 3-16:1, 4-16:1)[mm] + 1-acylglycerophosphocholine (18:1)[mm] YPR140W Glycerophospholipid metabolism +r_2800 MLCL (1-16:1, 2-18:1, 4-16:1):PC (1-16:0, 2-18:1) acyltransferase, mitochondrial membrane monolysocardiolipin (1-16:1, 2-18:1, 4-16:1)[mm] + phosphatidylcholine (1-16:0, 2-18:1)[mm] <=> cardiolipin (1-16:1, 2-18:1, 3-18:1, 4-16:1)[mm] + 1-acylglycerophosphocholine (16:0)[mm] YPR140W Glycerophospholipid metabolism +r_2801 MLCL (1-16:1, 2-18:1, 4-16:1):PC (1-16:1, 2-18:1) acyltransferase, mitochondrial membrane monolysocardiolipin (1-16:1, 2-18:1, 4-16:1)[mm] + phosphatidylcholine (1-16:1, 2-18:1)[mm] <=> cardiolipin (1-16:1, 2-18:1, 3-18:1, 4-16:1)[mm] + 1-acylglycerophosphocholine (16:1)[mm] YPR140W Glycerophospholipid metabolism +r_2802 MLCL (1-16:1, 2-18:1, 4-16:1):PC (1-18:0, 2-18:1) acyltransferase, mitochondrial membrane monolysocardiolipin (1-16:1, 2-18:1, 4-16:1)[mm] + phosphatidylcholine (1-18:0, 2-18:1)[mm] <=> cardiolipin (1-16:1, 2-18:1, 3-18:1, 4-16:1)[mm] + 1-acylglycerophosphocholine (18:0)[mm] YPR140W Glycerophospholipid metabolism +r_2803 MLCL (1-16:1, 2-18:1, 4-16:1):PC (1-18:1, 2-18:1) acyltransferase, mitochondrial membrane monolysocardiolipin (1-16:1, 2-18:1, 4-16:1)[mm] + phosphatidylcholine (1-18:1, 2-18:1)[mm] <=> cardiolipin (1-16:1, 2-18:1, 3-18:1, 4-16:1)[mm] + 1-acylglycerophosphocholine (18:1)[mm] YPR140W Glycerophospholipid metabolism +r_2804 MLCL (1-16:1, 2-18:1, 4-18:1):PC (1-16:0, 2-16:1) acyltransferase, mitochondrial membrane monolysocardiolipin (1-16:1, 2-18:1, 4-18:1)[mm] + phosphatidylcholine (1-16:0, 2-16:1)[mm] <=> cardiolipin (1-16:1, 2-18:1, 3-16:1, 4-18:1)[mm] + 1-acylglycerophosphocholine (16:0)[mm] YPR140W Glycerophospholipid metabolism +r_2805 MLCL (1-16:1, 2-18:1, 4-18:1):PC (1-16:1, 2-16:1) acyltransferase, mitochondrial membrane monolysocardiolipin (1-16:1, 2-18:1, 4-18:1)[mm] + phosphatidylcholine (1-16:1, 2-16:1)[mm] <=> cardiolipin (1-16:1, 2-18:1, 3-16:1, 4-18:1)[mm] + 1-acylglycerophosphocholine (16:1)[mm] YPR140W Glycerophospholipid metabolism +r_2806 MLCL (1-16:1, 2-18:1, 4-18:1):PC (1-18:0, 2-16:1) acyltransferase, mitochondrial membrane monolysocardiolipin (1-16:1, 2-18:1, 4-18:1)[mm] + phosphatidylcholine (1-18:0, 2-16:1)[mm] <=> cardiolipin (1-16:1, 2-18:1, 3-16:1, 4-18:1)[mm] + 1-acylglycerophosphocholine (18:0)[mm] YPR140W Glycerophospholipid metabolism +r_2807 MLCL (1-16:1, 2-18:1, 4-18:1):PC (1-18:1, 2-16:1) acyltransferase, mitochondrial membrane monolysocardiolipin (1-16:1, 2-18:1, 4-18:1)[mm] + phosphatidylcholine (1-18:1, 2-16:1)[mm] <=> cardiolipin (1-16:1, 2-18:1, 3-16:1, 4-18:1)[mm] + 1-acylglycerophosphocholine (18:1)[mm] YPR140W Glycerophospholipid metabolism +r_2808 MLCL (1-16:1, 2-18:1, 4-18:1):PC (1-16:0, 2-18:1) acyltransferase, mitochondrial membrane monolysocardiolipin (1-16:1, 2-18:1, 4-18:1)[mm] + phosphatidylcholine (1-16:0, 2-18:1)[mm] <=> 1-acylglycerophosphocholine (16:0)[mm] + cardiolipin (1-16:1, 2-18:1, 3-18:1, 4-18:1)[mm] YPR140W Glycerophospholipid metabolism +r_2809 MLCL (1-16:1, 2-18:1, 4-18:1):PC (1-16:1, 2-18:1) acyltransferase, mitochondrial membrane monolysocardiolipin (1-16:1, 2-18:1, 4-18:1)[mm] + phosphatidylcholine (1-16:1, 2-18:1)[mm] <=> 1-acylglycerophosphocholine (16:1)[mm] + cardiolipin (1-16:1, 2-18:1, 3-18:1, 4-18:1)[mm] YPR140W Glycerophospholipid metabolism +r_2810 MLCL (1-16:1, 2-18:1, 4-18:1):PC (1-18:0, 2-18:1) acyltransferase, mitochondrial membrane monolysocardiolipin (1-16:1, 2-18:1, 4-18:1)[mm] + phosphatidylcholine (1-18:0, 2-18:1)[mm] <=> 1-acylglycerophosphocholine (18:0)[mm] + cardiolipin (1-16:1, 2-18:1, 3-18:1, 4-18:1)[mm] YPR140W Glycerophospholipid metabolism +r_2811 MLCL (1-16:1, 2-18:1, 4-18:1):PC (1-18:1, 2-18:1) acyltransferase, mitochondrial membrane monolysocardiolipin (1-16:1, 2-18:1, 4-18:1)[mm] + phosphatidylcholine (1-18:1, 2-18:1)[mm] <=> 1-acylglycerophosphocholine (18:1)[mm] + cardiolipin (1-16:1, 2-18:1, 3-18:1, 4-18:1)[mm] YPR140W Glycerophospholipid metabolism +r_2812 lysoPC acyltransferase (1-16:0, 2-16:1), mitochondrial membrane 1-acylglycerophosphocholine (16:0)[mm] + palmitoleoyl-CoA(4-)[mm] => phosphatidylcholine (1-16:0, 2-16:1)[mm] + coenzyme A[mm] Glycerophospholipid metabolism +r_2813 lysoPC acyltransferase (1-16:0, 2-18:1), mitochondrial membrane 1-acylglycerophosphocholine (16:0)[mm] + oleoyl-CoA[mm] => phosphatidylcholine (1-16:0, 2-18:1)[mm] + coenzyme A[mm] Glycerophospholipid metabolism +r_2814 lysoPC acyltransferase (1-16:1, 2-16:1), mitochondrial membrane 1-acylglycerophosphocholine (16:1)[mm] + palmitoleoyl-CoA(4-)[mm] => phosphatidylcholine (1-16:1, 2-16:1)[mm] + coenzyme A[mm] Glycerophospholipid metabolism +r_2815 lysoPC acyltransferase (1-16:1, 2-18:1), mitochondrial membrane 1-acylglycerophosphocholine (16:1)[mm] + oleoyl-CoA[mm] => phosphatidylcholine (1-16:1, 2-18:1)[mm] + coenzyme A[mm] Glycerophospholipid metabolism +r_2816 lysoPC acyltransferase (1-18:0, 2-16:1), mitochondrial membrane 1-acylglycerophosphocholine (18:0)[mm] + palmitoleoyl-CoA(4-)[mm] => phosphatidylcholine (1-18:0, 2-16:1)[mm] + coenzyme A[mm] Glycerophospholipid metabolism +r_2817 lysoPC acyltransferase (1-18:0, 2-18:1), mitochondrial membrane 1-acylglycerophosphocholine (18:0)[mm] + oleoyl-CoA[mm] => phosphatidylcholine (1-18:0, 2-18:1)[mm] + coenzyme A[mm] Glycerophospholipid metabolism +r_2818 lysoPC acyltransferase (1-18:1, 2-16:1), mitochondrial membrane 1-acylglycerophosphocholine (18:1)[mm] + palmitoleoyl-CoA(4-)[mm] => phosphatidylcholine (1-18:1, 2-16:1)[mm] + coenzyme A[mm] Glycerophospholipid metabolism +r_2819 lysoPC acyltransferase (1-18:1, 2-18:1), mitochondrial membrane 1-acylglycerophosphocholine (18:1)[mm] + oleoyl-CoA[mm] => phosphatidylcholine (1-18:1, 2-18:1)[mm] + coenzyme A[mm] Glycerophospholipid metabolism +r_2820 phosphatidylinositol 4-kinase (1-16:0, 2-16:1), cell envelope H+[ce] + ATP[ce] + 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-16:1)[ce] => ADP[ce] + 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-16:0, 2-16:1)[ce] YJL100W or YLR305C Inositol phosphate metabolism +r_2821 phosphatidylinositol 4-kinase (1-16:1, 2-16:1), cell envelope H+[ce] + ATP[ce] + 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-16:1)[ce] => ADP[ce] + 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-16:1, 2-16:1)[ce] YJL100W or YLR305C Inositol phosphate metabolism +r_2822 phosphatidylinositol 4-kinase (1-18:0, 2-16:1), cell envelope H+[ce] + ATP[ce] + 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-16:1)[ce] => ADP[ce] + 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-18:0, 2-16:1)[ce] YJL100W or YLR305C Inositol phosphate metabolism +r_2823 phosphatidylinositol 4-kinase (1-18:1, 2-16:1), cell envelope H+[ce] + ATP[ce] + 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-16:1)[ce] => ADP[ce] + 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-18:1, 2-16:1)[ce] YJL100W or YLR305C Inositol phosphate metabolism +r_2824 phosphatidylinositol 4-kinase (1-16:0, 2-18:1), cell envelope H+[ce] + ATP[ce] + 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-18:1)[ce] => ADP[ce] + 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-16:0, 2-18:1)[ce] YJL100W or YLR305C Inositol phosphate metabolism +r_2825 phosphatidylinositol 4-kinase (1-16:1, 2-18:1), cell envelope H+[ce] + ATP[ce] + 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-18:1)[ce] => ADP[ce] + 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-16:1, 2-18:1)[ce] YJL100W or YLR305C Inositol phosphate metabolism +r_2826 phosphatidylinositol 4-kinase (1-18:0, 2-18:1), cell envelope H+[ce] + ATP[ce] + 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-18:1)[ce] => ADP[ce] + 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-18:0, 2-18:1)[ce] YJL100W or YLR305C Inositol phosphate metabolism +r_2827 phosphatidylinositol 4-kinase (1-18:1, 2-18:1), cell envelope H+[ce] + ATP[ce] + 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-18:1)[ce] => ADP[ce] + 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-18:1, 2-18:1)[ce] YJL100W or YLR305C Inositol phosphate metabolism +r_2828 phosphatidylinositol 4-kinase (1-16:0, 2-16:1), vacuolar membrane H+[vm] + 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-16:1)[vm] + ATP[vm] => ADP[vm] + 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-16:0, 2-16:1)[vm] YJL100W Inositol phosphate metabolism +r_2829 phosphatidylinositol 4-kinase (1-16:1, 2-16:1), vacuolar membrane H+[vm] + ATP[vm] + 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-16:1)[vm] => ADP[vm] + 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-16:1, 2-16:1)[vm] YJL100W Inositol phosphate metabolism +r_2830 phosphatidylinositol 4-kinase (1-18:0, 2-16:1), vacuolar membrane H+[vm] + ATP[vm] + 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-16:1)[vm] => ADP[vm] + 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-18:0, 2-16:1)[vm] YJL100W Inositol phosphate metabolism +r_2831 phosphatidylinositol 4-kinase (1-18:1, 2-16:1), vacuolar membrane H+[vm] + ATP[vm] + 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-16:1)[vm] => ADP[vm] + 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-18:1, 2-16:1)[vm] YJL100W Inositol phosphate metabolism +r_2832 phosphatidylinositol 4-kinase (1-16:0, 2-18:1), vacuolar membrane H+[vm] + ATP[vm] + 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-18:1)[vm] => ADP[vm] + 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-16:0, 2-18:1)[vm] YJL100W Inositol phosphate metabolism +r_2833 phosphatidylinositol 4-kinase (1-16:1, 2-18:1), vacuolar membrane H+[vm] + ATP[vm] + 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-18:1)[vm] => ADP[vm] + 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-16:1, 2-18:1)[vm] YJL100W Inositol phosphate metabolism +r_2834 phosphatidylinositol 4-kinase (1-18:0, 2-18:1), vacuolar membrane H+[vm] + ATP[vm] + 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-18:1)[vm] => ADP[vm] + 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-18:0, 2-18:1)[vm] YJL100W Inositol phosphate metabolism +r_2835 phosphatidylinositol 4-kinase (1-18:1, 2-18:1), vacuolar membrane H+[vm] + ATP[vm] + 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-18:1)[vm] => ADP[vm] + 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-18:1, 2-18:1)[vm] YJL100W Inositol phosphate metabolism +r_2836 phosphatidylinositol 4-kinase (1-16:0, 2-16:1), Golgi membrane H+[gm] + 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-16:1)[gm] + ATP[gm] => ADP[gm] + 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-16:0, 2-16:1)[gm] YDR373W and YNL267W Inositol phosphate metabolism +r_2837 phosphatidylinositol 4-kinase (1-16:1, 2-16:1), Golgi membrane H+[gm] + ATP[gm] + 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-16:1)[gm] => ADP[gm] + 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-16:1, 2-16:1)[gm] YDR373W and YNL267W Inositol phosphate metabolism +r_2838 phosphatidylinositol 4-kinase (1-18:0, 2-16:1), Golgi membrane H+[gm] + ATP[gm] + 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-16:1)[gm] => ADP[gm] + 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-18:0, 2-16:1)[gm] YDR373W and YNL267W Inositol phosphate metabolism +r_2839 phosphatidylinositol 4-kinase (1-18:1, 2-16:1), Golgi membrane H+[gm] + ATP[gm] + 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-16:1)[gm] => ADP[gm] + 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-18:1, 2-16:1)[gm] YDR373W and YNL267W Inositol phosphate metabolism +r_2840 phosphatidylinositol 4-kinase (1-16:0, 2-18:1), Golgi membrane H+[gm] + ATP[gm] + 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-18:1)[gm] => ADP[gm] + 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-16:0, 2-18:1)[gm] YDR373W and YNL267W Inositol phosphate metabolism +r_2841 phosphatidylinositol 4-kinase (1-16:1, 2-18:1), Golgi membrane H+[gm] + ATP[gm] + 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-18:1)[gm] => ADP[gm] + 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-16:1, 2-18:1)[gm] YDR373W and YNL267W Inositol phosphate metabolism +r_2842 phosphatidylinositol 4-kinase (1-18:0, 2-18:1), Golgi membrane H+[gm] + ATP[gm] + 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-18:1)[gm] => ADP[gm] + 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-18:0, 2-18:1)[gm] YDR373W and YNL267W Inositol phosphate metabolism +r_2843 phosphatidylinositol 4-kinase (1-18:1, 2-18:1), Golgi membrane H+[gm] + ATP[gm] + 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-18:1)[gm] => ADP[gm] + 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-18:1, 2-18:1)[gm] YDR373W and YNL267W Inositol phosphate metabolism +r_2844 phosphatidylinositol 4-kinase (1-16:0, 2-16:1), nucleus ATP[n] + H+[n] + 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-16:1)[n] => ADP[n] + 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-16:0, 2-16:1)[n] YNL267W Inositol phosphate metabolism +r_2845 phosphatidylinositol 4-kinase (1-16:1, 2-16:1), nucleus ATP[n] + H+[n] + 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-16:1)[n] => ADP[n] + 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-16:1, 2-16:1)[n] YNL267W Inositol phosphate metabolism +r_2846 phosphatidylinositol 4-kinase (1-18:0, 2-16:1), nucleus ATP[n] + H+[n] + 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-16:1)[n] => ADP[n] + 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-18:0, 2-16:1)[n] YNL267W Inositol phosphate metabolism +r_2847 phosphatidylinositol 4-kinase (1-18:1, 2-16:1), nucleus ATP[n] + H+[n] + 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-16:1)[n] => ADP[n] + 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-18:1, 2-16:1)[n] YNL267W Inositol phosphate metabolism +r_2848 phosphatidylinositol 4-kinase (1-16:0, 2-18:1), nucleus ATP[n] + H+[n] + 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-18:1)[n] => ADP[n] + 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-16:0, 2-18:1)[n] YNL267W Inositol phosphate metabolism +r_2849 phosphatidylinositol 4-kinase (1-16:1, 2-18:1), nucleus ATP[n] + H+[n] + 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-18:1)[n] => ADP[n] + 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-16:1, 2-18:1)[n] YNL267W Inositol phosphate metabolism +r_2850 phosphatidylinositol 4-kinase (1-18:0, 2-18:1), nucleus ATP[n] + H+[n] + 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-18:1)[n] => ADP[n] + 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-18:0, 2-18:1)[n] YNL267W Inositol phosphate metabolism +r_2851 phosphatidylinositol 4-kinase (1-18:1, 2-18:1), nucleus ATP[n] + H+[n] + 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-18:1)[n] => ADP[n] + 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-18:1, 2-18:1)[n] YNL267W Inositol phosphate metabolism +r_2852 phosphatidylinositol 3-kinase (1-16:0, 2-16:1), vacuolar membrane H+[vm] + 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-16:1)[vm] + ATP[vm] => ADP[vm] + 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-16:0, 2-16:1)[vm] YBR097W and YLR240W Inositol phosphate metabolism +r_2853 phosphatidylinositol 3-kinase (1-16:1, 2-16:1), vacuolar membrane H+[vm] + ATP[vm] + 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-16:1)[vm] => ADP[vm] + 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-16:1, 2-16:1)[vm] YBR097W and YLR240W Inositol phosphate metabolism +r_2854 phosphatidylinositol 3-kinase (1-18:0, 2-16:1), vacuolar membrane H+[vm] + ATP[vm] + 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-16:1)[vm] => ADP[vm] + 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-18:0, 2-16:1)[vm] YBR097W and YLR240W Inositol phosphate metabolism +r_2855 phosphatidylinositol 3-kinase (1-18:1, 2-16:1), vacuolar membrane H+[vm] + ATP[vm] + 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-16:1)[vm] => ADP[vm] + 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-18:1, 2-16:1)[vm] YBR097W and YLR240W Inositol phosphate metabolism +r_2856 phosphatidylinositol 3-kinase (1-16:0, 2-18:1), vacuolar membrane H+[vm] + ATP[vm] + 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-18:1)[vm] => ADP[vm] + 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-16:0, 2-18:1)[vm] YBR097W and YLR240W Inositol phosphate metabolism +r_2857 phosphatidylinositol 3-kinase (1-16:1, 2-18:1), vacuolar membrane H+[vm] + ATP[vm] + 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-18:1)[vm] => ADP[vm] + 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-16:1, 2-18:1)[vm] YBR097W and YLR240W Inositol phosphate metabolism +r_2858 phosphatidylinositol 3-kinase (1-18:0, 2-18:1), vacuolar membrane H+[vm] + ATP[vm] + 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-18:1)[vm] => ADP[vm] + 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-18:0, 2-18:1)[vm] YBR097W and YLR240W Inositol phosphate metabolism +r_2859 phosphatidylinositol 3-kinase (1-18:1, 2-18:1), vacuolar membrane H+[vm] + ATP[vm] + 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-18:1)[vm] => ADP[vm] + 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-18:1, 2-18:1)[vm] YBR097W and YLR240W Inositol phosphate metabolism +r_2860 PI 4-P 5-kinase (1-16:0, 2-16:1), nucleus ATP[n] + H+[n] + 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-16:0, 2-16:1)[n] => ADP[n] + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-16:0, 2-16:1)[n] YDR208W Inositol phosphate metabolism +r_2861 PI 4-P 5-kinase (1-16:1, 2-16:1), nucleus ATP[n] + H+[n] + 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-16:1, 2-16:1)[n] => ADP[n] + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-16:1, 2-16:1)[n] YDR208W Inositol phosphate metabolism +r_2862 PI 4-P 5-kinase (1-18:0, 2-16:1), nucleus ATP[n] + H+[n] + 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-18:0, 2-16:1)[n] => ADP[n] + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-18:0, 2-16:1)[n] YDR208W Inositol phosphate metabolism +r_2863 PI 4-P 5-kinase (1-18:1, 2-16:1), nucleus ATP[n] + H+[n] + 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-18:1, 2-16:1)[n] => ADP[n] + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-18:1, 2-16:1)[n] YDR208W Inositol phosphate metabolism +r_2864 PI 4-P 5-kinase (1-16:0, 2-18:1), nucleus ATP[n] + H+[n] + 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-16:0, 2-18:1)[n] => ADP[n] + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-16:0, 2-18:1)[n] YDR208W Inositol phosphate metabolism +r_2865 PI 4-P 5-kinase (1-16:1, 2-18:1), nucleus ATP[n] + H+[n] + 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-16:1, 2-18:1)[n] => ADP[n] + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-16:1, 2-18:1)[n] YDR208W Inositol phosphate metabolism +r_2866 PI 4-P 5-kinase (1-18:0, 2-18:1), nucleus ATP[n] + H+[n] + 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-18:0, 2-18:1)[n] => ADP[n] + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-18:0, 2-18:1)[n] YDR208W Inositol phosphate metabolism +r_2867 PI 4-P 5-kinase (1-18:1, 2-18:1), nucleus ATP[n] + H+[n] + 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-18:1, 2-18:1)[n] => ADP[n] + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-18:1, 2-18:1)[n] YDR208W Inositol phosphate metabolism +r_2868 PI 4-P 5-kinase (1-16:0, 2-16:1), cell envelope H+[ce] + ATP[ce] + 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-16:0, 2-16:1)[ce] => ADP[ce] + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-16:0, 2-16:1)[ce] YDR208W Inositol phosphate metabolism +r_2869 PI 4-P 5-kinase (1-16:1, 2-16:1), cell envelope H+[ce] + ATP[ce] + 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-16:1, 2-16:1)[ce] => ADP[ce] + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-16:1, 2-16:1)[ce] YDR208W Inositol phosphate metabolism +r_2870 PI 4-P 5-kinase (1-18:0, 2-16:1), cell envelope H+[ce] + ATP[ce] + 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-18:0, 2-16:1)[ce] => ADP[ce] + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-18:0, 2-16:1)[ce] YDR208W Inositol phosphate metabolism +r_2871 PI 4-P 5-kinase (1-18:1, 2-16:1), cell envelope H+[ce] + ATP[ce] + 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-18:1, 2-16:1)[ce] => ADP[ce] + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-18:1, 2-16:1)[ce] YDR208W Inositol phosphate metabolism +r_2872 PI 4-P 5-kinase (1-16:0, 2-18:1), cell envelope H+[ce] + ATP[ce] + 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-16:0, 2-18:1)[ce] => ADP[ce] + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-16:0, 2-18:1)[ce] YDR208W Inositol phosphate metabolism +r_2873 PI 4-P 5-kinase (1-16:1, 2-18:1), cell envelope H+[ce] + ATP[ce] + 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-16:1, 2-18:1)[ce] => ADP[ce] + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-16:1, 2-18:1)[ce] YDR208W Inositol phosphate metabolism +r_2874 PI 4-P 5-kinase (1-18:0, 2-18:1), cell envelope H+[ce] + ATP[ce] + 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-18:0, 2-18:1)[ce] => ADP[ce] + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-18:0, 2-18:1)[ce] YDR208W Inositol phosphate metabolism +r_2875 PI 4-P 5-kinase (1-18:1, 2-18:1), cell envelope H+[ce] + ATP[ce] + 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-18:1, 2-18:1)[ce] => ADP[ce] + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-18:1, 2-18:1)[ce] YDR208W Inositol phosphate metabolism +r_2876 PI 3-P 5-kinase (1-16:0, 2-16:1), vacuolar membrane H+[vm] + ATP[vm] + 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-16:0, 2-16:1)[vm] => ADP[vm] + 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-16:0, 2-16:1)[vm] YFR019W Inositol phosphate metabolism +r_2877 PI 3-P 5-kinase (1-16:1, 2-16:1), vacuolar membrane H+[vm] + ATP[vm] + 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-16:1, 2-16:1)[vm] => ADP[vm] + 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-16:1, 2-16:1)[vm] YFR019W Inositol phosphate metabolism +r_2878 PI 3-P 5-kinase (1-18:0, 2-16:1), vacuolar membrane H+[vm] + ATP[vm] + 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-18:0, 2-16:1)[vm] => ADP[vm] + 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-18:0, 2-16:1)[vm] YFR019W Inositol phosphate metabolism +r_2879 PI 3-P 5-kinase (1-18:1, 2-16:1), vacuolar membrane H+[vm] + ATP[vm] + 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-18:1, 2-16:1)[vm] => ADP[vm] + 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-18:1, 2-16:1)[vm] YFR019W Inositol phosphate metabolism +r_2880 PI 3-P 5-kinase (1-16:0, 2-18:1), vacuolar membrane H+[vm] + ATP[vm] + 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-16:0, 2-18:1)[vm] => ADP[vm] + 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-16:0, 2-18:1)[vm] YFR019W Inositol phosphate metabolism +r_2881 PI 3-P 5-kinase (1-16:1, 2-18:1), vacuolar membrane H+[vm] + ATP[vm] + 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-16:1, 2-18:1)[vm] => ADP[vm] + 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-16:1, 2-18:1)[vm] YFR019W Inositol phosphate metabolism +r_2882 PI 3-P 5-kinase (1-18:0, 2-18:1), vacuolar membrane H+[vm] + ATP[vm] + 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-18:0, 2-18:1)[vm] => ADP[vm] + 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-18:0, 2-18:1)[vm] YFR019W Inositol phosphate metabolism +r_2883 PI 3-P 5-kinase (1-18:1, 2-18:1), vacuolar membrane H+[vm] + ATP[vm] + 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-18:1, 2-18:1)[vm] => ADP[vm] + 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-18:1, 2-18:1)[vm] YFR019W Inositol phosphate metabolism +r_2884 PE (1-16:0, 2-16:1) diacylglycerol (1-16:0, 2-16:1) acyltransferase, ER membrane diglyceride (1-16:0, 2-16:1)[erm] + phosphatidylethanolamine (1-16:0, 2-16:1)[erm] <=> triglyceride (1-16:0, 2-16:1, 3-16:1)[erm] + 1-acylglycerophosphoethanolamine (16:0)[erm] YNR008W Glycerolipid metabolism +r_2885 PE (1-16:1, 2-16:1) diacylglycerol (1-16:0, 2-16:1) acyltransferase, ER membrane diglyceride (1-16:0, 2-16:1)[erm] + phosphatidylethanolamine (1-16:1, 2-16:1)[erm] <=> triglyceride (1-16:0, 2-16:1, 3-16:1)[erm] + 1-acylglycerophosphoethanolamine (16:1)[erm] YNR008W Glycerolipid metabolism +r_2886 PE (1-18:0, 2-16:1) diacylglycerol (1-16:0, 2-16:1) acyltransferase, ER membrane diglyceride (1-16:0, 2-16:1)[erm] + phosphatidylethanolamine (1-18:0, 2-16:1)[erm] <=> triglyceride (1-16:0, 2-16:1, 3-16:1)[erm] + 1-acylglycerophosphoethanolamine (18:0)[erm] YNR008W Glycerolipid metabolism +r_2887 PE (1-18:1, 2-16:1) diacylglycerol (1-16:0, 2-16:1) acyltransferase, ER membrane diglyceride (1-16:0, 2-16:1)[erm] + phosphatidylethanolamine (1-18:1, 2-16:1)[erm] <=> triglyceride (1-16:0, 2-16:1, 3-16:1)[erm] + 1-acylglycerophosphoethanolamine (18:1)[erm] YNR008W Glycerolipid metabolism +r_2888 PE (1-16:0, 2-18:1) diacylglycerol (1-16:0, 2-16:1) acyltransferase, ER membrane diglyceride (1-16:0, 2-16:1)[erm] + phosphatidylethanolamine (1-16:0, 2-18:1)[erm] <=> triglyceride (1-16:0, 2-16:1, 3-18:1)[erm] + 1-acylglycerophosphoethanolamine (16:0)[erm] YNR008W Glycerolipid metabolism +r_2889 PE (1-16:1, 2-18:1) diacylglycerol (1-16:0, 2-16:1) acyltransferase, ER membrane diglyceride (1-16:0, 2-16:1)[erm] + phosphatidylethanolamine (1-16:1, 2-18:1)[erm] <=> triglyceride (1-16:0, 2-16:1, 3-18:1)[erm] + 1-acylglycerophosphoethanolamine (16:1)[erm] YNR008W Glycerolipid metabolism +r_2890 PE (1-18:0, 2-18:1) diacylglycerol (1-16:0, 2-16:1) acyltransferase, ER membrane diglyceride (1-16:0, 2-16:1)[erm] + phosphatidylethanolamine (1-18:0, 2-18:1)[erm] <=> triglyceride (1-16:0, 2-16:1, 3-18:1)[erm] + 1-acylglycerophosphoethanolamine (18:0)[erm] YNR008W Glycerolipid metabolism +r_2891 PE (1-18:1, 2-18:1) diacylglycerol (1-16:0, 2-16:1) acyltransferase, ER membrane diglyceride (1-16:0, 2-16:1)[erm] + phosphatidylethanolamine (1-18:1, 2-18:1)[erm] <=> triglyceride (1-16:0, 2-16:1, 3-18:1)[erm] + 1-acylglycerophosphoethanolamine (18:1)[erm] YNR008W Glycerolipid metabolism +r_2892 PE (1-16:0, 2-16:1) diacylglycerol (1-16:1, 2-16:1) acyltransferase, ER membrane diglyceride (1-16:1, 2-16:1)[erm] + phosphatidylethanolamine (1-16:0, 2-16:1)[erm] <=> triglyceride (1-16:1, 2-16:1, 3-16:1)[erm] + 1-acylglycerophosphoethanolamine (16:0)[erm] YNR008W Glycerolipid metabolism +r_2893 PE (1-16:1, 2-16:1) diacylglycerol (1-16:1, 2-16:1) acyltransferase, ER membrane diglyceride (1-16:1, 2-16:1)[erm] + phosphatidylethanolamine (1-16:1, 2-16:1)[erm] <=> triglyceride (1-16:1, 2-16:1, 3-16:1)[erm] + 1-acylglycerophosphoethanolamine (16:1)[erm] YNR008W Glycerolipid metabolism +r_2894 PE (1-18:0, 2-16:1) diacylglycerol (1-16:1, 2-16:1) acyltransferase, ER membrane diglyceride (1-16:1, 2-16:1)[erm] + phosphatidylethanolamine (1-18:0, 2-16:1)[erm] <=> triglyceride (1-16:1, 2-16:1, 3-16:1)[erm] + 1-acylglycerophosphoethanolamine (18:0)[erm] YNR008W Glycerolipid metabolism +r_2895 PE (1-18:1, 2-16:1) diacylglycerol (1-16:1, 2-16:1) acyltransferase, ER membrane diglyceride (1-16:1, 2-16:1)[erm] + phosphatidylethanolamine (1-18:1, 2-16:1)[erm] <=> triglyceride (1-16:1, 2-16:1, 3-16:1)[erm] + 1-acylglycerophosphoethanolamine (18:1)[erm] YNR008W Glycerolipid metabolism +r_2896 PE (1-16:0, 2-18:1) diacylglycerol (1-16:1, 2-16:1) acyltransferase, ER membrane diglyceride (1-16:1, 2-16:1)[erm] + phosphatidylethanolamine (1-16:0, 2-18:1)[erm] <=> triglyceride (1-16:1, 2-16:1, 3-18:1)[erm] + 1-acylglycerophosphoethanolamine (16:0)[erm] YNR008W Glycerolipid metabolism +r_2897 PE (1-16:1, 2-18:1) diacylglycerol (1-16:1, 2-16:1) acyltransferase, ER membrane diglyceride (1-16:1, 2-16:1)[erm] + phosphatidylethanolamine (1-16:1, 2-18:1)[erm] <=> triglyceride (1-16:1, 2-16:1, 3-18:1)[erm] + 1-acylglycerophosphoethanolamine (16:1)[erm] YNR008W Glycerolipid metabolism +r_2898 PE (1-18:0, 2-18:1) diacylglycerol (1-16:1, 2-16:1) acyltransferase, ER membrane diglyceride (1-16:1, 2-16:1)[erm] + phosphatidylethanolamine (1-18:0, 2-18:1)[erm] <=> triglyceride (1-16:1, 2-16:1, 3-18:1)[erm] + 1-acylglycerophosphoethanolamine (18:0)[erm] YNR008W Glycerolipid metabolism +r_2899 PE (1-18:1, 2-18:1) diacylglycerol (1-16:1, 2-16:1) acyltransferase, ER membrane diglyceride (1-16:1, 2-16:1)[erm] + phosphatidylethanolamine (1-18:1, 2-18:1)[erm] <=> triglyceride (1-16:1, 2-16:1, 3-18:1)[erm] + 1-acylglycerophosphoethanolamine (18:1)[erm] YNR008W Glycerolipid metabolism +r_2900 PE (1-16:0, 2-16:1) diacylglycerol (1-18:0, 2-16:1) acyltransferase, ER membrane diglyceride (1-18:0, 2-16:1)[erm] + phosphatidylethanolamine (1-16:0, 2-16:1)[erm] <=> triglyceride (1-18:0, 2-16:1, 3-16:1)[erm] + 1-acylglycerophosphoethanolamine (16:0)[erm] YNR008W Glycerolipid metabolism +r_2901 PE (1-16:1, 2-16:1) diacylglycerol (1-18:0, 2-16:1) acyltransferase, ER membrane diglyceride (1-18:0, 2-16:1)[erm] + phosphatidylethanolamine (1-16:1, 2-16:1)[erm] <=> triglyceride (1-18:0, 2-16:1, 3-16:1)[erm] + 1-acylglycerophosphoethanolamine (16:1)[erm] YNR008W Glycerolipid metabolism +r_2902 PE (1-18:0, 2-16:1) diacylglycerol (1-18:0, 2-16:1) acyltransferase, ER membrane diglyceride (1-18:0, 2-16:1)[erm] + phosphatidylethanolamine (1-18:0, 2-16:1)[erm] <=> triglyceride (1-18:0, 2-16:1, 3-16:1)[erm] + 1-acylglycerophosphoethanolamine (18:0)[erm] YNR008W Glycerolipid metabolism +r_2903 PE (1-18:1, 2-16:1) diacylglycerol (1-18:0, 2-16:1) acyltransferase, ER membrane diglyceride (1-18:0, 2-16:1)[erm] + phosphatidylethanolamine (1-18:1, 2-16:1)[erm] <=> triglyceride (1-18:0, 2-16:1, 3-16:1)[erm] + 1-acylglycerophosphoethanolamine (18:1)[erm] YNR008W Glycerolipid metabolism +r_2904 PE (1-16:0, 2-18:1) diacylglycerol (1-18:0, 2-16:1) acyltransferase, ER membrane diglyceride (1-18:0, 2-16:1)[erm] + phosphatidylethanolamine (1-16:0, 2-18:1)[erm] <=> triglyceride (1-18:0, 2-16:1, 3-18:1)[erm] + 1-acylglycerophosphoethanolamine (16:0)[erm] YNR008W Glycerolipid metabolism +r_2905 PE (1-16:1, 2-18:1) diacylglycerol (1-18:0, 2-16:1) acyltransferase, ER membrane diglyceride (1-18:0, 2-16:1)[erm] + phosphatidylethanolamine (1-16:1, 2-18:1)[erm] <=> triglyceride (1-18:0, 2-16:1, 3-18:1)[erm] + 1-acylglycerophosphoethanolamine (16:1)[erm] YNR008W Glycerolipid metabolism +r_2906 PE (1-18:0, 2-18:1) diacylglycerol (1-18:0, 2-16:1) acyltransferase, ER membrane diglyceride (1-18:0, 2-16:1)[erm] + phosphatidylethanolamine (1-18:0, 2-18:1)[erm] <=> triglyceride (1-18:0, 2-16:1, 3-18:1)[erm] + 1-acylglycerophosphoethanolamine (18:0)[erm] YNR008W Glycerolipid metabolism +r_2907 PE (1-18:1, 2-18:1) diacylglycerol (1-18:0, 2-16:1) acyltransferase, ER membrane diglyceride (1-18:0, 2-16:1)[erm] + phosphatidylethanolamine (1-18:1, 2-18:1)[erm] <=> triglyceride (1-18:0, 2-16:1, 3-18:1)[erm] + 1-acylglycerophosphoethanolamine (18:1)[erm] YNR008W Glycerolipid metabolism +r_2908 PE (1-16:0, 2-16:1) diacylglycerol (1-18:1, 2-16:1) acyltransferase, ER membrane diglyceride (1-18:1, 2-16:1)[erm] + phosphatidylethanolamine (1-16:0, 2-16:1)[erm] <=> triglyceride (1-18:1, 2-16:1, 3-16:1)[erm] + 1-acylglycerophosphoethanolamine (16:0)[erm] YNR008W Glycerolipid metabolism +r_2909 PE (1-16:1, 2-16:1) diacylglycerol (1-18:1, 2-16:1) acyltransferase, ER membrane diglyceride (1-18:1, 2-16:1)[erm] + phosphatidylethanolamine (1-16:1, 2-16:1)[erm] <=> triglyceride (1-18:1, 2-16:1, 3-16:1)[erm] + 1-acylglycerophosphoethanolamine (16:1)[erm] YNR008W Glycerolipid metabolism +r_2910 PE (1-18:0, 2-16:1) diacylglycerol (1-18:1, 2-16:1) acyltransferase, ER membrane diglyceride (1-18:1, 2-16:1)[erm] + phosphatidylethanolamine (1-18:0, 2-16:1)[erm] <=> triglyceride (1-18:1, 2-16:1, 3-16:1)[erm] + 1-acylglycerophosphoethanolamine (18:0)[erm] YNR008W Glycerolipid metabolism +r_2911 PE (1-18:1, 2-16:1) diacylglycerol (1-18:1, 2-16:1) acyltransferase, ER membrane diglyceride (1-18:1, 2-16:1)[erm] + phosphatidylethanolamine (1-18:1, 2-16:1)[erm] <=> triglyceride (1-18:1, 2-16:1, 3-16:1)[erm] + 1-acylglycerophosphoethanolamine (18:1)[erm] YNR008W Glycerolipid metabolism +r_2912 PE (1-16:0, 2-18:1) diacylglycerol (1-18:1, 2-16:1) acyltransferase, ER membrane diglyceride (1-18:1, 2-16:1)[erm] + phosphatidylethanolamine (1-16:0, 2-18:1)[erm] <=> triglyceride (1-18:1, 2-16:1, 3-18:1)[erm] + 1-acylglycerophosphoethanolamine (16:0)[erm] YNR008W Glycerolipid metabolism +r_2913 PE (1-16:1, 2-18:1) diacylglycerol (1-18:1, 2-16:1) acyltransferase, ER membrane diglyceride (1-18:1, 2-16:1)[erm] + phosphatidylethanolamine (1-16:1, 2-18:1)[erm] <=> triglyceride (1-18:1, 2-16:1, 3-18:1)[erm] + 1-acylglycerophosphoethanolamine (16:1)[erm] YNR008W Glycerolipid metabolism +r_2914 PE (1-18:0, 2-18:1) diacylglycerol (1-18:1, 2-16:1) acyltransferase, ER membrane diglyceride (1-18:1, 2-16:1)[erm] + phosphatidylethanolamine (1-18:0, 2-18:1)[erm] <=> triglyceride (1-18:1, 2-16:1, 3-18:1)[erm] + 1-acylglycerophosphoethanolamine (18:0)[erm] YNR008W Glycerolipid metabolism +r_2915 PE (1-18:1, 2-18:1) diacylglycerol (1-18:1, 2-16:1) acyltransferase, ER membrane diglyceride (1-18:1, 2-16:1)[erm] + phosphatidylethanolamine (1-18:1, 2-18:1)[erm] <=> triglyceride (1-18:1, 2-16:1, 3-18:1)[erm] + 1-acylglycerophosphoethanolamine (18:1)[erm] YNR008W Glycerolipid metabolism +r_2916 PE (1-16:0, 2-16:1) diacylglycerol (1-16:0, 2-18:1) acyltransferase, ER membrane diglyceride (1-16:0, 2-18:1)[erm] + phosphatidylethanolamine (1-16:0, 2-16:1)[erm] <=> triglyceride (1-16:0, 2-18:1, 3-16:1)[erm] + 1-acylglycerophosphoethanolamine (16:0)[erm] YNR008W Glycerolipid metabolism +r_2917 PE (1-16:1, 2-16:1) diacylglycerol (1-16:0, 2-18:1) acyltransferase, ER membrane diglyceride (1-16:0, 2-18:1)[erm] + phosphatidylethanolamine (1-16:1, 2-16:1)[erm] <=> triglyceride (1-16:0, 2-18:1, 3-16:1)[erm] + 1-acylglycerophosphoethanolamine (16:1)[erm] YNR008W Glycerolipid metabolism +r_2918 PE (1-18:0, 2-16:1) diacylglycerol (1-16:0, 2-18:1) acyltransferase, ER membrane diglyceride (1-16:0, 2-18:1)[erm] + phosphatidylethanolamine (1-18:0, 2-16:1)[erm] <=> triglyceride (1-16:0, 2-18:1, 3-16:1)[erm] + 1-acylglycerophosphoethanolamine (18:0)[erm] YNR008W Glycerolipid metabolism +r_2919 PE (1-18:1, 2-16:1) diacylglycerol (1-16:0, 2-18:1) acyltransferase, ER membrane diglyceride (1-16:0, 2-18:1)[erm] + phosphatidylethanolamine (1-18:1, 2-16:1)[erm] <=> triglyceride (1-16:0, 2-18:1, 3-16:1)[erm] + 1-acylglycerophosphoethanolamine (18:1)[erm] YNR008W Glycerolipid metabolism +r_2920 PE (1-16:0, 2-18:1) diacylglycerol (1-16:0, 2-18:1) acyltransferase, ER membrane diglyceride (1-16:0, 2-18:1)[erm] + phosphatidylethanolamine (1-16:0, 2-18:1)[erm] <=> triglyceride (1-16:0, 2-18:1, 3-18:1)[erm] + 1-acylglycerophosphoethanolamine (16:0)[erm] YNR008W Glycerolipid metabolism +r_2921 PE (1-16:1, 2-18:1) diacylglycerol (1-16:0, 2-18:1) acyltransferase, ER membrane diglyceride (1-16:0, 2-18:1)[erm] + phosphatidylethanolamine (1-16:1, 2-18:1)[erm] <=> triglyceride (1-16:0, 2-18:1, 3-18:1)[erm] + 1-acylglycerophosphoethanolamine (16:1)[erm] YNR008W Glycerolipid metabolism +r_2922 PE (1-18:0, 2-18:1) diacylglycerol (1-16:0, 2-18:1) acyltransferase, ER membrane diglyceride (1-16:0, 2-18:1)[erm] + phosphatidylethanolamine (1-18:0, 2-18:1)[erm] <=> triglyceride (1-16:0, 2-18:1, 3-18:1)[erm] + 1-acylglycerophosphoethanolamine (18:0)[erm] YNR008W Glycerolipid metabolism +r_2923 PE (1-18:1, 2-18:1) diacylglycerol (1-16:0, 2-18:1) acyltransferase, ER membrane diglyceride (1-16:0, 2-18:1)[erm] + phosphatidylethanolamine (1-18:1, 2-18:1)[erm] <=> triglyceride (1-16:0, 2-18:1, 3-18:1)[erm] + 1-acylglycerophosphoethanolamine (18:1)[erm] YNR008W Glycerolipid metabolism +r_2924 PE (1-16:0, 2-16:1) diacylglycerol (1-16:1, 2-18:1) acyltransferase, ER membrane diglyceride (1-16:1, 2-18:1)[erm] + phosphatidylethanolamine (1-16:0, 2-16:1)[erm] <=> triglyceride (1-16:1, 2-18:1, 3-16:1)[erm] + 1-acylglycerophosphoethanolamine (16:0)[erm] YNR008W Glycerolipid metabolism +r_2925 PE (1-16:1, 2-16:1) diacylglycerol (1-16:1, 2-18:1) acyltransferase, ER membrane diglyceride (1-16:1, 2-18:1)[erm] + phosphatidylethanolamine (1-16:1, 2-16:1)[erm] <=> triglyceride (1-16:1, 2-18:1, 3-16:1)[erm] + 1-acylglycerophosphoethanolamine (16:1)[erm] YNR008W Glycerolipid metabolism +r_2926 PE (1-18:0, 2-16:1) diacylglycerol (1-16:1, 2-18:1) acyltransferase, ER membrane diglyceride (1-16:1, 2-18:1)[erm] + phosphatidylethanolamine (1-18:0, 2-16:1)[erm] <=> triglyceride (1-16:1, 2-18:1, 3-16:1)[erm] + 1-acylglycerophosphoethanolamine (18:0)[erm] YNR008W Glycerolipid metabolism +r_2927 PE (1-18:1, 2-16:1) diacylglycerol (1-16:1, 2-18:1) acyltransferase, ER membrane diglyceride (1-16:1, 2-18:1)[erm] + phosphatidylethanolamine (1-18:1, 2-16:1)[erm] <=> triglyceride (1-16:1, 2-18:1, 3-16:1)[erm] + 1-acylglycerophosphoethanolamine (18:1)[erm] YNR008W Glycerolipid metabolism +r_2928 PE (1-16:0, 2-18:1) diacylglycerol (1-16:1, 2-18:1) acyltransferase, ER membrane diglyceride (1-16:1, 2-18:1)[erm] + phosphatidylethanolamine (1-16:0, 2-18:1)[erm] <=> triglyceride (1-16:1, 2-18:1, 3-18:1)[erm] + 1-acylglycerophosphoethanolamine (16:0)[erm] YNR008W Glycerolipid metabolism +r_2929 PE (1-16:1, 2-18:1) diacylglycerol (1-16:1, 2-18:1) acyltransferase, ER membrane diglyceride (1-16:1, 2-18:1)[erm] + phosphatidylethanolamine (1-16:1, 2-18:1)[erm] <=> triglyceride (1-16:1, 2-18:1, 3-18:1)[erm] + 1-acylglycerophosphoethanolamine (16:1)[erm] YNR008W Glycerolipid metabolism +r_2930 PE (1-18:0, 2-18:1) diacylglycerol (1-16:1, 2-18:1) acyltransferase, ER membrane diglyceride (1-16:1, 2-18:1)[erm] + phosphatidylethanolamine (1-18:0, 2-18:1)[erm] <=> triglyceride (1-16:1, 2-18:1, 3-18:1)[erm] + 1-acylglycerophosphoethanolamine (18:0)[erm] YNR008W Glycerolipid metabolism +r_2931 PE (1-18:1, 2-18:1) diacylglycerol (1-16:1, 2-18:1) acyltransferase, ER membrane diglyceride (1-16:1, 2-18:1)[erm] + phosphatidylethanolamine (1-18:1, 2-18:1)[erm] <=> triglyceride (1-16:1, 2-18:1, 3-18:1)[erm] + 1-acylglycerophosphoethanolamine (18:1)[erm] YNR008W Glycerolipid metabolism +r_2932 PE (1-16:0, 2-16:1) diacylglycerol (1-18:0, 2-18:1) acyltransferase, ER membrane diglyceride (1-18:0, 2-18:1)[erm] + phosphatidylethanolamine (1-16:0, 2-16:1)[erm] <=> triglyceride (1-18:0, 2-18:1, 3-16:1)[erm] + 1-acylglycerophosphoethanolamine (16:0)[erm] YNR008W Glycerolipid metabolism +r_2933 PE (1-16:1, 2-16:1) diacylglycerol (1-18:0, 2-18:1) acyltransferase, ER membrane diglyceride (1-18:0, 2-18:1)[erm] + phosphatidylethanolamine (1-16:1, 2-16:1)[erm] <=> triglyceride (1-18:0, 2-18:1, 3-16:1)[erm] + 1-acylglycerophosphoethanolamine (16:1)[erm] YNR008W Glycerolipid metabolism +r_2934 PE (1-18:0, 2-16:1) diacylglycerol (1-18:0, 2-18:1) acyltransferase, ER membrane diglyceride (1-18:0, 2-18:1)[erm] + phosphatidylethanolamine (1-18:0, 2-16:1)[erm] <=> triglyceride (1-18:0, 2-18:1, 3-16:1)[erm] + 1-acylglycerophosphoethanolamine (18:0)[erm] YNR008W Glycerolipid metabolism +r_2935 PE (1-18:1, 2-16:1) diacylglycerol (1-18:0, 2-18:1) acyltransferase, ER membrane diglyceride (1-18:0, 2-18:1)[erm] + phosphatidylethanolamine (1-18:1, 2-16:1)[erm] <=> triglyceride (1-18:0, 2-18:1, 3-16:1)[erm] + 1-acylglycerophosphoethanolamine (18:1)[erm] YNR008W Glycerolipid metabolism +r_2936 PE (1-16:0, 2-18:1) diacylglycerol (1-18:0, 2-18:1) acyltransferase, ER membrane diglyceride (1-18:0, 2-18:1)[erm] + phosphatidylethanolamine (1-16:0, 2-18:1)[erm] <=> triglyceride (1-18:0, 2-18:1, 3-18:1)[erm] + 1-acylglycerophosphoethanolamine (16:0)[erm] YNR008W Glycerolipid metabolism +r_2937 PE (1-16:1, 2-18:1) diacylglycerol (1-18:0, 2-18:1) acyltransferase, ER membrane diglyceride (1-18:0, 2-18:1)[erm] + phosphatidylethanolamine (1-16:1, 2-18:1)[erm] <=> triglyceride (1-18:0, 2-18:1, 3-18:1)[erm] + 1-acylglycerophosphoethanolamine (16:1)[erm] YNR008W Glycerolipid metabolism +r_2938 PE (1-18:0, 2-18:1) diacylglycerol (1-18:0, 2-18:1) acyltransferase, ER membrane diglyceride (1-18:0, 2-18:1)[erm] + phosphatidylethanolamine (1-18:0, 2-18:1)[erm] <=> triglyceride (1-18:0, 2-18:1, 3-18:1)[erm] + 1-acylglycerophosphoethanolamine (18:0)[erm] YNR008W Glycerolipid metabolism +r_2939 PE (1-18:1, 2-18:1) diacylglycerol (1-18:0, 2-18:1) acyltransferase, ER membrane diglyceride (1-18:0, 2-18:1)[erm] + phosphatidylethanolamine (1-18:1, 2-18:1)[erm] <=> triglyceride (1-18:0, 2-18:1, 3-18:1)[erm] + 1-acylglycerophosphoethanolamine (18:1)[erm] YNR008W Glycerolipid metabolism +r_2940 PE (1-16:0, 2-16:1) diacylglycerol (1-18:1, 2-18:1) acyltransferase, ER membrane diglyceride (1-18:1, 2-18:1)[erm] + phosphatidylethanolamine (1-16:0, 2-16:1)[erm] <=> triglyceride (1-18:1, 2-18:1, 3-16:1)[erm] + 1-acylglycerophosphoethanolamine (16:0)[erm] YNR008W Glycerolipid metabolism +r_2941 PE (1-16:1, 2-16:1) diacylglycerol (1-18:1, 2-18:1) acyltransferase, ER membrane diglyceride (1-18:1, 2-18:1)[erm] + phosphatidylethanolamine (1-16:1, 2-16:1)[erm] <=> triglyceride (1-18:1, 2-18:1, 3-16:1)[erm] + 1-acylglycerophosphoethanolamine (16:1)[erm] YNR008W Glycerolipid metabolism +r_2942 PE (1-18:0, 2-16:1) diacylglycerol (1-18:1, 2-18:1) acyltransferase, ER membrane diglyceride (1-18:1, 2-18:1)[erm] + phosphatidylethanolamine (1-18:0, 2-16:1)[erm] <=> triglyceride (1-18:1, 2-18:1, 3-16:1)[erm] + 1-acylglycerophosphoethanolamine (18:0)[erm] YNR008W Glycerolipid metabolism +r_2943 PE (1-18:1, 2-16:1) diacylglycerol (1-18:1, 2-18:1) acyltransferase, ER membrane diglyceride (1-18:1, 2-18:1)[erm] + phosphatidylethanolamine (1-18:1, 2-16:1)[erm] <=> triglyceride (1-18:1, 2-18:1, 3-16:1)[erm] + 1-acylglycerophosphoethanolamine (18:1)[erm] YNR008W Glycerolipid metabolism +r_2944 PE (1-16:0, 2-18:1) diacylglycerol (1-18:1, 2-18:1) acyltransferase, ER membrane diglyceride (1-18:1, 2-18:1)[erm] + phosphatidylethanolamine (1-16:0, 2-18:1)[erm] <=> triglyceride (1-18:1, 2-18:1, 3-18:1)[erm] + 1-acylglycerophosphoethanolamine (16:0)[erm] YNR008W Glycerolipid metabolism +r_2945 PE (1-16:1, 2-18:1) diacylglycerol (1-18:1, 2-18:1) acyltransferase, ER membrane diglyceride (1-18:1, 2-18:1)[erm] + phosphatidylethanolamine (1-16:1, 2-18:1)[erm] <=> triglyceride (1-18:1, 2-18:1, 3-18:1)[erm] + 1-acylglycerophosphoethanolamine (16:1)[erm] YNR008W Glycerolipid metabolism +r_2946 PE (1-18:0, 2-18:1) diacylglycerol (1-18:1, 2-18:1) acyltransferase, ER membrane diglyceride (1-18:1, 2-18:1)[erm] + phosphatidylethanolamine (1-18:0, 2-18:1)[erm] <=> triglyceride (1-18:1, 2-18:1, 3-18:1)[erm] + 1-acylglycerophosphoethanolamine (18:0)[erm] YNR008W Glycerolipid metabolism +r_2947 PE (1-18:1, 2-18:1) diacylglycerol (1-18:1, 2-18:1) acyltransferase, ER membrane diglyceride (1-18:1, 2-18:1)[erm] + phosphatidylethanolamine (1-18:1, 2-18:1)[erm] <=> triglyceride (1-18:1, 2-18:1, 3-18:1)[erm] + 1-acylglycerophosphoethanolamine (18:1)[erm] YNR008W Glycerolipid metabolism +r_2948 PC (1-16:0, 2-16:1) diacylglycerol (1-16:0, 2-16:1) acyltransferase, ER membrane diglyceride (1-16:0, 2-16:1)[erm] + phosphatidylcholine (1-16:0, 2-16:1)[erm] <=> triglyceride (1-16:0, 2-16:1, 3-16:1)[erm] + 1-acylglycerophosphocholine (16:0)[erm] YNR008W Glycerolipid metabolism +r_2949 PC (1-16:1, 2-16:1) diacylglycerol (1-16:0, 2-16:1) acyltransferase, ER membrane diglyceride (1-16:0, 2-16:1)[erm] + phosphatidylcholine (1-16:1, 2-16:1)[erm] <=> triglyceride (1-16:0, 2-16:1, 3-16:1)[erm] + 1-acylglycerophosphocholine (16:1)[erm] YNR008W Glycerolipid metabolism +r_2950 PC (1-18:0, 2-16:1) diacylglycerol (1-16:0, 2-16:1) acyltransferase, ER membrane diglyceride (1-16:0, 2-16:1)[erm] + phosphatidylcholine (1-18:0, 2-16:1)[erm] <=> triglyceride (1-16:0, 2-16:1, 3-16:1)[erm] + 1-acylglycerophosphocholine (18:0)[erm] YNR008W Glycerolipid metabolism +r_2951 PC (1-18:1, 2-16:1) diacylglycerol (1-16:0, 2-16:1) acyltransferase, ER membrane diglyceride (1-16:0, 2-16:1)[erm] + phosphatidylcholine (1-18:1, 2-16:1)[erm] <=> triglyceride (1-16:0, 2-16:1, 3-16:1)[erm] + 1-acylglycerophosphocholine (18:1)[erm] YNR008W Glycerolipid metabolism +r_2952 PC (1-16:0, 2-18:1) diacylglycerol (1-16:0, 2-16:1) acyltransferase, ER membrane diglyceride (1-16:0, 2-16:1)[erm] + phosphatidylcholine (1-16:0, 2-18:1)[erm] <=> triglyceride (1-16:0, 2-16:1, 3-18:1)[erm] + 1-acylglycerophosphocholine (16:0)[erm] YNR008W Glycerolipid metabolism +r_2953 PC (1-16:1, 2-18:1) diacylglycerol (1-16:0, 2-16:1) acyltransferase, ER membrane diglyceride (1-16:0, 2-16:1)[erm] + phosphatidylcholine (1-16:1, 2-18:1)[erm] <=> triglyceride (1-16:0, 2-16:1, 3-18:1)[erm] + 1-acylglycerophosphocholine (16:1)[erm] YNR008W Glycerolipid metabolism +r_2954 PC (1-18:0, 2-18:1) diacylglycerol (1-16:0, 2-16:1) acyltransferase, ER membrane diglyceride (1-16:0, 2-16:1)[erm] + phosphatidylcholine (1-18:0, 2-18:1)[erm] <=> triglyceride (1-16:0, 2-16:1, 3-18:1)[erm] + 1-acylglycerophosphocholine (18:0)[erm] YNR008W Glycerolipid metabolism +r_2955 PC (1-18:1, 2-18:1) diacylglycerol (1-16:0, 2-16:1) acyltransferase, ER membrane diglyceride (1-16:0, 2-16:1)[erm] + phosphatidylcholine (1-18:1, 2-18:1)[erm] <=> triglyceride (1-16:0, 2-16:1, 3-18:1)[erm] + 1-acylglycerophosphocholine (18:1)[erm] YNR008W Glycerolipid metabolism +r_2956 PC (1-16:0, 2-16:1) diacylglycerol (1-16:1, 2-16:1) acyltransferase, ER membrane diglyceride (1-16:1, 2-16:1)[erm] + phosphatidylcholine (1-16:0, 2-16:1)[erm] <=> triglyceride (1-16:1, 2-16:1, 3-16:1)[erm] + 1-acylglycerophosphocholine (16:0)[erm] YNR008W Glycerolipid metabolism +r_2957 PC (1-16:1, 2-16:1) diacylglycerol (1-16:1, 2-16:1) acyltransferase, ER membrane diglyceride (1-16:1, 2-16:1)[erm] + phosphatidylcholine (1-16:1, 2-16:1)[erm] <=> triglyceride (1-16:1, 2-16:1, 3-16:1)[erm] + 1-acylglycerophosphocholine (16:1)[erm] YNR008W Glycerolipid metabolism +r_2958 PC (1-18:0, 2-16:1) diacylglycerol (1-16:1, 2-16:1) acyltransferase, ER membrane diglyceride (1-16:1, 2-16:1)[erm] + phosphatidylcholine (1-18:0, 2-16:1)[erm] <=> triglyceride (1-16:1, 2-16:1, 3-16:1)[erm] + 1-acylglycerophosphocholine (18:0)[erm] YNR008W Glycerolipid metabolism +r_2959 PC (1-18:1, 2-16:1) diacylglycerol (1-16:1, 2-16:1) acyltransferase, ER membrane diglyceride (1-16:1, 2-16:1)[erm] + phosphatidylcholine (1-18:1, 2-16:1)[erm] <=> triglyceride (1-16:1, 2-16:1, 3-16:1)[erm] + 1-acylglycerophosphocholine (18:1)[erm] YNR008W Glycerolipid metabolism +r_2960 PC (1-16:0, 2-18:1) diacylglycerol (1-16:1, 2-16:1) acyltransferase, ER membrane diglyceride (1-16:1, 2-16:1)[erm] + phosphatidylcholine (1-16:0, 2-18:1)[erm] <=> triglyceride (1-16:1, 2-16:1, 3-18:1)[erm] + 1-acylglycerophosphocholine (16:0)[erm] YNR008W Glycerolipid metabolism +r_2961 PC (1-16:1, 2-18:1) diacylglycerol (1-16:1, 2-16:1) acyltransferase, ER membrane diglyceride (1-16:1, 2-16:1)[erm] + phosphatidylcholine (1-16:1, 2-18:1)[erm] <=> triglyceride (1-16:1, 2-16:1, 3-18:1)[erm] + 1-acylglycerophosphocholine (16:1)[erm] YNR008W Glycerolipid metabolism +r_2962 PC (1-18:0, 2-18:1) diacylglycerol (1-16:1, 2-16:1) acyltransferase, ER membrane diglyceride (1-16:1, 2-16:1)[erm] + phosphatidylcholine (1-18:0, 2-18:1)[erm] <=> triglyceride (1-16:1, 2-16:1, 3-18:1)[erm] + 1-acylglycerophosphocholine (18:0)[erm] YNR008W Glycerolipid metabolism +r_2963 PC (1-18:1, 2-18:1) diacylglycerol (1-16:1, 2-16:1) acyltransferase, ER membrane diglyceride (1-16:1, 2-16:1)[erm] + phosphatidylcholine (1-18:1, 2-18:1)[erm] <=> triglyceride (1-16:1, 2-16:1, 3-18:1)[erm] + 1-acylglycerophosphocholine (18:1)[erm] YNR008W Glycerolipid metabolism +r_2964 PC (1-16:0, 2-16:1) diacylglycerol (1-18:0, 2-16:1) acyltransferase, ER membrane diglyceride (1-18:0, 2-16:1)[erm] + phosphatidylcholine (1-16:0, 2-16:1)[erm] <=> triglyceride (1-18:0, 2-16:1, 3-16:1)[erm] + 1-acylglycerophosphocholine (16:0)[erm] YNR008W Glycerolipid metabolism +r_2965 PC (1-16:1, 2-16:1) diacylglycerol (1-18:0, 2-16:1) acyltransferase, ER membrane diglyceride (1-18:0, 2-16:1)[erm] + phosphatidylcholine (1-16:1, 2-16:1)[erm] <=> triglyceride (1-18:0, 2-16:1, 3-16:1)[erm] + 1-acylglycerophosphocholine (16:1)[erm] YNR008W Glycerolipid metabolism +r_2966 PC (1-18:0, 2-16:1) diacylglycerol (1-18:0, 2-16:1) acyltransferase, ER membrane diglyceride (1-18:0, 2-16:1)[erm] + phosphatidylcholine (1-18:0, 2-16:1)[erm] <=> triglyceride (1-18:0, 2-16:1, 3-16:1)[erm] + 1-acylglycerophosphocholine (18:0)[erm] YNR008W Glycerolipid metabolism +r_2967 PC (1-18:1, 2-16:1) diacylglycerol (1-18:0, 2-16:1) acyltransferase, ER membrane diglyceride (1-18:0, 2-16:1)[erm] + phosphatidylcholine (1-18:1, 2-16:1)[erm] <=> triglyceride (1-18:0, 2-16:1, 3-16:1)[erm] + 1-acylglycerophosphocholine (18:1)[erm] YNR008W Glycerolipid metabolism +r_2968 PC (1-16:0, 2-18:1) diacylglycerol (1-18:0, 2-16:1) acyltransferase, ER membrane diglyceride (1-18:0, 2-16:1)[erm] + phosphatidylcholine (1-16:0, 2-18:1)[erm] <=> triglyceride (1-18:0, 2-16:1, 3-18:1)[erm] + 1-acylglycerophosphocholine (16:0)[erm] YNR008W Glycerolipid metabolism +r_2969 PC (1-16:1, 2-18:1) diacylglycerol (1-18:0, 2-16:1) acyltransferase, ER membrane diglyceride (1-18:0, 2-16:1)[erm] + phosphatidylcholine (1-16:1, 2-18:1)[erm] <=> triglyceride (1-18:0, 2-16:1, 3-18:1)[erm] + 1-acylglycerophosphocholine (16:1)[erm] YNR008W Glycerolipid metabolism +r_2970 PC (1-18:0, 2-18:1) diacylglycerol (1-18:0, 2-16:1) acyltransferase, ER membrane diglyceride (1-18:0, 2-16:1)[erm] + phosphatidylcholine (1-18:0, 2-18:1)[erm] <=> triglyceride (1-18:0, 2-16:1, 3-18:1)[erm] + 1-acylglycerophosphocholine (18:0)[erm] YNR008W Glycerolipid metabolism +r_2971 PC (1-18:1, 2-18:1) diacylglycerol (1-18:0, 2-16:1) acyltransferase, ER membrane diglyceride (1-18:0, 2-16:1)[erm] + phosphatidylcholine (1-18:1, 2-18:1)[erm] <=> triglyceride (1-18:0, 2-16:1, 3-18:1)[erm] + 1-acylglycerophosphocholine (18:1)[erm] YNR008W Glycerolipid metabolism +r_2972 PC (1-16:0, 2-16:1) diacylglycerol (1-18:1, 2-16:1) acyltransferase, ER membrane diglyceride (1-18:1, 2-16:1)[erm] + phosphatidylcholine (1-16:0, 2-16:1)[erm] <=> triglyceride (1-18:1, 2-16:1, 3-16:1)[erm] + 1-acylglycerophosphocholine (16:0)[erm] YNR008W Glycerolipid metabolism +r_2973 PC (1-16:1, 2-16:1) diacylglycerol (1-18:1, 2-16:1) acyltransferase, ER membrane diglyceride (1-18:1, 2-16:1)[erm] + phosphatidylcholine (1-16:1, 2-16:1)[erm] <=> triglyceride (1-18:1, 2-16:1, 3-16:1)[erm] + 1-acylglycerophosphocholine (16:1)[erm] YNR008W Glycerolipid metabolism +r_2974 PC (1-18:0, 2-16:1) diacylglycerol (1-18:1, 2-16:1) acyltransferase, ER membrane diglyceride (1-18:1, 2-16:1)[erm] + phosphatidylcholine (1-18:0, 2-16:1)[erm] <=> triglyceride (1-18:1, 2-16:1, 3-16:1)[erm] + 1-acylglycerophosphocholine (18:0)[erm] YNR008W Glycerolipid metabolism +r_2975 PC (1-18:1, 2-16:1) diacylglycerol (1-18:1, 2-16:1) acyltransferase, ER membrane diglyceride (1-18:1, 2-16:1)[erm] + phosphatidylcholine (1-18:1, 2-16:1)[erm] <=> triglyceride (1-18:1, 2-16:1, 3-16:1)[erm] + 1-acylglycerophosphocholine (18:1)[erm] YNR008W Glycerolipid metabolism +r_2976 PC (1-16:0, 2-18:1) diacylglycerol (1-18:1, 2-16:1) acyltransferase, ER membrane diglyceride (1-18:1, 2-16:1)[erm] + phosphatidylcholine (1-16:0, 2-18:1)[erm] <=> triglyceride (1-18:1, 2-16:1, 3-18:1)[erm] + 1-acylglycerophosphocholine (16:0)[erm] YNR008W Glycerolipid metabolism +r_2977 PC (1-16:1, 2-18:1) diacylglycerol (1-18:1, 2-16:1) acyltransferase, ER membrane diglyceride (1-18:1, 2-16:1)[erm] + phosphatidylcholine (1-16:1, 2-18:1)[erm] <=> triglyceride (1-18:1, 2-16:1, 3-18:1)[erm] + 1-acylglycerophosphocholine (16:1)[erm] YNR008W Glycerolipid metabolism +r_2978 PC (1-18:0, 2-18:1) diacylglycerol (1-18:1, 2-16:1) acyltransferase, ER membrane diglyceride (1-18:1, 2-16:1)[erm] + phosphatidylcholine (1-18:0, 2-18:1)[erm] <=> triglyceride (1-18:1, 2-16:1, 3-18:1)[erm] + 1-acylglycerophosphocholine (18:0)[erm] YNR008W Glycerolipid metabolism +r_2979 PC (1-18:1, 2-18:1) diacylglycerol (1-18:1, 2-16:1) acyltransferase, ER membrane diglyceride (1-18:1, 2-16:1)[erm] + phosphatidylcholine (1-18:1, 2-18:1)[erm] <=> triglyceride (1-18:1, 2-16:1, 3-18:1)[erm] + 1-acylglycerophosphocholine (18:1)[erm] YNR008W Glycerolipid metabolism +r_2980 PC (1-16:0, 2-16:1) diacylglycerol (1-16:0, 2-18:1) acyltransferase, ER membrane diglyceride (1-16:0, 2-18:1)[erm] + phosphatidylcholine (1-16:0, 2-16:1)[erm] <=> triglyceride (1-16:0, 2-18:1, 3-16:1)[erm] + 1-acylglycerophosphocholine (16:0)[erm] YNR008W Glycerolipid metabolism +r_2981 PC (1-16:1, 2-16:1) diacylglycerol (1-16:0, 2-18:1) acyltransferase, ER membrane diglyceride (1-16:0, 2-18:1)[erm] + phosphatidylcholine (1-16:1, 2-16:1)[erm] <=> triglyceride (1-16:0, 2-18:1, 3-16:1)[erm] + 1-acylglycerophosphocholine (16:1)[erm] YNR008W Glycerolipid metabolism +r_2982 PC (1-18:0, 2-16:1) diacylglycerol (1-16:0, 2-18:1) acyltransferase, ER membrane diglyceride (1-16:0, 2-18:1)[erm] + phosphatidylcholine (1-18:0, 2-16:1)[erm] <=> triglyceride (1-16:0, 2-18:1, 3-16:1)[erm] + 1-acylglycerophosphocholine (18:0)[erm] YNR008W Glycerolipid metabolism +r_2983 PC (1-18:1, 2-16:1) diacylglycerol (1-16:0, 2-18:1) acyltransferase, ER membrane diglyceride (1-16:0, 2-18:1)[erm] + phosphatidylcholine (1-18:1, 2-16:1)[erm] <=> triglyceride (1-16:0, 2-18:1, 3-16:1)[erm] + 1-acylglycerophosphocholine (18:1)[erm] YNR008W Glycerolipid metabolism +r_2984 PC (1-16:0, 2-18:1) diacylglycerol (1-16:0, 2-18:1) acyltransferase, ER membrane diglyceride (1-16:0, 2-18:1)[erm] + phosphatidylcholine (1-16:0, 2-18:1)[erm] <=> triglyceride (1-16:0, 2-18:1, 3-18:1)[erm] + 1-acylglycerophosphocholine (16:0)[erm] YNR008W Glycerolipid metabolism +r_2985 PC (1-16:1, 2-18:1) diacylglycerol (1-16:0, 2-18:1) acyltransferase, ER membrane diglyceride (1-16:0, 2-18:1)[erm] + phosphatidylcholine (1-16:1, 2-18:1)[erm] <=> triglyceride (1-16:0, 2-18:1, 3-18:1)[erm] + 1-acylglycerophosphocholine (16:1)[erm] YNR008W Glycerolipid metabolism +r_2986 PC (1-18:0, 2-18:1) diacylglycerol (1-16:0, 2-18:1) acyltransferase, ER membrane diglyceride (1-16:0, 2-18:1)[erm] + phosphatidylcholine (1-18:0, 2-18:1)[erm] <=> triglyceride (1-16:0, 2-18:1, 3-18:1)[erm] + 1-acylglycerophosphocholine (18:0)[erm] YNR008W Glycerolipid metabolism +r_2987 PC (1-18:1, 2-18:1) diacylglycerol (1-16:0, 2-18:1) acyltransferase, ER membrane diglyceride (1-16:0, 2-18:1)[erm] + phosphatidylcholine (1-18:1, 2-18:1)[erm] <=> triglyceride (1-16:0, 2-18:1, 3-18:1)[erm] + 1-acylglycerophosphocholine (18:1)[erm] YNR008W Glycerolipid metabolism +r_2988 PC (1-16:0, 2-16:1) diacylglycerol (1-16:1, 2-18:1) acyltransferase, ER membrane diglyceride (1-16:1, 2-18:1)[erm] + phosphatidylcholine (1-16:0, 2-16:1)[erm] <=> triglyceride (1-16:1, 2-18:1, 3-16:1)[erm] + 1-acylglycerophosphocholine (16:0)[erm] YNR008W Glycerolipid metabolism +r_2989 PC (1-16:1, 2-16:1) diacylglycerol (1-16:1, 2-18:1) acyltransferase, ER membrane diglyceride (1-16:1, 2-18:1)[erm] + phosphatidylcholine (1-16:1, 2-16:1)[erm] <=> triglyceride (1-16:1, 2-18:1, 3-16:1)[erm] + 1-acylglycerophosphocholine (16:1)[erm] YNR008W Glycerolipid metabolism +r_2990 PC (1-18:0, 2-16:1) diacylglycerol (1-16:1, 2-18:1) acyltransferase, ER membrane diglyceride (1-16:1, 2-18:1)[erm] + phosphatidylcholine (1-18:0, 2-16:1)[erm] <=> triglyceride (1-16:1, 2-18:1, 3-16:1)[erm] + 1-acylglycerophosphocholine (18:0)[erm] YNR008W Glycerolipid metabolism +r_2991 PC (1-18:1, 2-16:1) diacylglycerol (1-16:1, 2-18:1) acyltransferase, ER membrane diglyceride (1-16:1, 2-18:1)[erm] + phosphatidylcholine (1-18:1, 2-16:1)[erm] <=> triglyceride (1-16:1, 2-18:1, 3-16:1)[erm] + 1-acylglycerophosphocholine (18:1)[erm] YNR008W Glycerolipid metabolism +r_2992 PC (1-16:0, 2-18:1) diacylglycerol (1-16:1, 2-18:1) acyltransferase, ER membrane diglyceride (1-16:1, 2-18:1)[erm] + phosphatidylcholine (1-16:0, 2-18:1)[erm] <=> triglyceride (1-16:1, 2-18:1, 3-18:1)[erm] + 1-acylglycerophosphocholine (16:0)[erm] YNR008W Glycerolipid metabolism +r_2993 PC (1-16:1, 2-18:1) diacylglycerol (1-16:1, 2-18:1) acyltransferase, ER membrane diglyceride (1-16:1, 2-18:1)[erm] + phosphatidylcholine (1-16:1, 2-18:1)[erm] <=> triglyceride (1-16:1, 2-18:1, 3-18:1)[erm] + 1-acylglycerophosphocholine (16:1)[erm] YNR008W Glycerolipid metabolism +r_2994 PC (1-18:0, 2-18:1) diacylglycerol (1-16:1, 2-18:1) acyltransferase, ER membrane diglyceride (1-16:1, 2-18:1)[erm] + phosphatidylcholine (1-18:0, 2-18:1)[erm] <=> triglyceride (1-16:1, 2-18:1, 3-18:1)[erm] + 1-acylglycerophosphocholine (18:0)[erm] YNR008W Glycerolipid metabolism +r_2995 PC (1-18:1, 2-18:1) diacylglycerol (1-16:1, 2-18:1) acyltransferase, ER membrane diglyceride (1-16:1, 2-18:1)[erm] + phosphatidylcholine (1-18:1, 2-18:1)[erm] <=> triglyceride (1-16:1, 2-18:1, 3-18:1)[erm] + 1-acylglycerophosphocholine (18:1)[erm] YNR008W Glycerolipid metabolism +r_2996 PC (1-16:0, 2-16:1) diacylglycerol (1-18:0, 2-18:1) acyltransferase, ER membrane diglyceride (1-18:0, 2-18:1)[erm] + phosphatidylcholine (1-16:0, 2-16:1)[erm] <=> triglyceride (1-18:0, 2-18:1, 3-16:1)[erm] + 1-acylglycerophosphocholine (16:0)[erm] YNR008W Glycerolipid metabolism +r_2997 PC (1-16:1, 2-16:1) diacylglycerol (1-18:0, 2-18:1) acyltransferase, ER membrane diglyceride (1-18:0, 2-18:1)[erm] + phosphatidylcholine (1-16:1, 2-16:1)[erm] <=> triglyceride (1-18:0, 2-18:1, 3-16:1)[erm] + 1-acylglycerophosphocholine (16:1)[erm] YNR008W Glycerolipid metabolism +r_2998 PC (1-18:0, 2-16:1) diacylglycerol (1-18:0, 2-18:1) acyltransferase, ER membrane diglyceride (1-18:0, 2-18:1)[erm] + phosphatidylcholine (1-18:0, 2-16:1)[erm] <=> triglyceride (1-18:0, 2-18:1, 3-16:1)[erm] + 1-acylglycerophosphocholine (18:0)[erm] YNR008W Glycerolipid metabolism +r_2999 PC (1-18:1, 2-16:1) diacylglycerol (1-18:0, 2-18:1) acyltransferase, ER membrane diglyceride (1-18:0, 2-18:1)[erm] + phosphatidylcholine (1-18:1, 2-16:1)[erm] <=> triglyceride (1-18:0, 2-18:1, 3-16:1)[erm] + 1-acylglycerophosphocholine (18:1)[erm] YNR008W Glycerolipid metabolism +r_3000 PC (1-16:0, 2-18:1) diacylglycerol (1-18:0, 2-18:1) acyltransferase, ER membrane diglyceride (1-18:0, 2-18:1)[erm] + phosphatidylcholine (1-16:0, 2-18:1)[erm] <=> triglyceride (1-18:0, 2-18:1, 3-18:1)[erm] + 1-acylglycerophosphocholine (16:0)[erm] YNR008W Glycerolipid metabolism +r_3001 PC (1-16:1, 2-18:1) diacylglycerol (1-18:0, 2-18:1) acyltransferase, ER membrane diglyceride (1-18:0, 2-18:1)[erm] + phosphatidylcholine (1-16:1, 2-18:1)[erm] <=> triglyceride (1-18:0, 2-18:1, 3-18:1)[erm] + 1-acylglycerophosphocholine (16:1)[erm] YNR008W Glycerolipid metabolism +r_3002 PC (1-18:0, 2-18:1) diacylglycerol (1-18:0, 2-18:1) acyltransferase, ER membrane diglyceride (1-18:0, 2-18:1)[erm] + phosphatidylcholine (1-18:0, 2-18:1)[erm] <=> triglyceride (1-18:0, 2-18:1, 3-18:1)[erm] + 1-acylglycerophosphocholine (18:0)[erm] YNR008W Glycerolipid metabolism +r_3003 PC (1-18:1, 2-18:1) diacylglycerol (1-18:0, 2-18:1) acyltransferase, ER membrane diglyceride (1-18:0, 2-18:1)[erm] + phosphatidylcholine (1-18:1, 2-18:1)[erm] <=> triglyceride (1-18:0, 2-18:1, 3-18:1)[erm] + 1-acylglycerophosphocholine (18:1)[erm] YNR008W Glycerolipid metabolism +r_3004 PC (1-16:0, 2-16:1) diacylglycerol (1-18:1, 2-18:1) acyltransferase, ER membrane diglyceride (1-18:1, 2-18:1)[erm] + phosphatidylcholine (1-16:0, 2-16:1)[erm] <=> triglyceride (1-18:1, 2-18:1, 3-16:1)[erm] + 1-acylglycerophosphocholine (16:0)[erm] YNR008W Glycerolipid metabolism +r_3005 PC (1-16:1, 2-16:1) diacylglycerol (1-18:1, 2-18:1) acyltransferase, ER membrane diglyceride (1-18:1, 2-18:1)[erm] + phosphatidylcholine (1-16:1, 2-16:1)[erm] <=> triglyceride (1-18:1, 2-18:1, 3-16:1)[erm] + 1-acylglycerophosphocholine (16:1)[erm] YNR008W Glycerolipid metabolism +r_3006 PC (1-18:0, 2-16:1) diacylglycerol (1-18:1, 2-18:1) acyltransferase, ER membrane diglyceride (1-18:1, 2-18:1)[erm] + phosphatidylcholine (1-18:0, 2-16:1)[erm] <=> triglyceride (1-18:1, 2-18:1, 3-16:1)[erm] + 1-acylglycerophosphocholine (18:0)[erm] YNR008W Glycerolipid metabolism +r_3007 PC (1-18:1, 2-16:1) diacylglycerol (1-18:1, 2-18:1) acyltransferase, ER membrane diglyceride (1-18:1, 2-18:1)[erm] + phosphatidylcholine (1-18:1, 2-16:1)[erm] <=> triglyceride (1-18:1, 2-18:1, 3-16:1)[erm] + 1-acylglycerophosphocholine (18:1)[erm] YNR008W Glycerolipid metabolism +r_3008 PC (1-16:0, 2-18:1) diacylglycerol (1-18:1, 2-18:1) acyltransferase, ER membrane diglyceride (1-18:1, 2-18:1)[erm] + phosphatidylcholine (1-16:0, 2-18:1)[erm] <=> triglyceride (1-18:1, 2-18:1, 3-18:1)[erm] + 1-acylglycerophosphocholine (16:0)[erm] YNR008W Glycerolipid metabolism +r_3009 PC (1-16:1, 2-18:1) diacylglycerol (1-18:1, 2-18:1) acyltransferase, ER membrane diglyceride (1-18:1, 2-18:1)[erm] + phosphatidylcholine (1-16:1, 2-18:1)[erm] <=> triglyceride (1-18:1, 2-18:1, 3-18:1)[erm] + 1-acylglycerophosphocholine (16:1)[erm] YNR008W Glycerolipid metabolism +r_3010 PC (1-18:0, 2-18:1) diacylglycerol (1-18:1, 2-18:1) acyltransferase, ER membrane diglyceride (1-18:1, 2-18:1)[erm] + phosphatidylcholine (1-18:0, 2-18:1)[erm] <=> triglyceride (1-18:1, 2-18:1, 3-18:1)[erm] + 1-acylglycerophosphocholine (18:0)[erm] YNR008W Glycerolipid metabolism +r_3011 PC (1-18:1, 2-18:1) diacylglycerol (1-18:1, 2-18:1) acyltransferase, ER membrane diglyceride (1-18:1, 2-18:1)[erm] + phosphatidylcholine (1-18:1, 2-18:1)[erm] <=> triglyceride (1-18:1, 2-18:1, 3-18:1)[erm] + 1-acylglycerophosphocholine (18:1)[erm] YNR008W Glycerolipid metabolism +r_3022 PC phospholipase B (1-16:0, 2-16:1), ER membrane H2O[erm] + phosphatidylcholine (1-16:0, 2-16:1)[erm] => H+[erm] + palmitoleate[erm] + 1-acylglycerophosphocholine (16:0)[erm] YML059C Glycerophospholipid metabolism +r_3023 PC phospholipase B (1-16:1, 2-16:1), ER membrane H2O[erm] + phosphatidylcholine (1-16:1, 2-16:1)[erm] => H+[erm] + palmitoleate[erm] + 1-acylglycerophosphocholine (16:1)[erm] YML059C Glycerophospholipid metabolism +r_3024 PC phospholipase B (1-18:0, 2-16:1), ER membrane H2O[erm] + phosphatidylcholine (1-18:0, 2-16:1)[erm] => H+[erm] + palmitoleate[erm] + 1-acylglycerophosphocholine (18:0)[erm] YML059C Glycerophospholipid metabolism +r_3025 PC phospholipase B (1-18:1, 2-16:1), ER membrane H2O[erm] + phosphatidylcholine (1-18:1, 2-16:1)[erm] => H+[erm] + palmitoleate[erm] + 1-acylglycerophosphocholine (18:1)[erm] YML059C Glycerophospholipid metabolism +r_3026 PC phospholipase B (1-16:0, 2-18:1), ER membrane H2O[erm] + phosphatidylcholine (1-16:0, 2-18:1)[erm] => H+[erm] + oleate[erm] + 1-acylglycerophosphocholine (16:0)[erm] YML059C Glycerophospholipid metabolism +r_3027 PC phospholipase B (1-16:1, 2-18:1), ER membrane H2O[erm] + phosphatidylcholine (1-16:1, 2-18:1)[erm] => H+[erm] + oleate[erm] + 1-acylglycerophosphocholine (16:1)[erm] YML059C Glycerophospholipid metabolism +r_3028 PC phospholipase B (1-18:0, 2-18:1), ER membrane H2O[erm] + phosphatidylcholine (1-18:0, 2-18:1)[erm] => H+[erm] + oleate[erm] + 1-acylglycerophosphocholine (18:0)[erm] YML059C Glycerophospholipid metabolism +r_3029 PC phospholipase B (1-18:1, 2-18:1), ER membrane H2O[erm] + phosphatidylcholine (1-18:1, 2-18:1)[erm] => H+[erm] + oleate[erm] + 1-acylglycerophosphocholine (18:1)[erm] YML059C Glycerophospholipid metabolism +r_3030 LPC phospholipase B (16:0), ER membrane H2O[erm] + 1-acylglycerophosphocholine (16:0)[erm] => H+[erm] + palmitate[erm] + sn-glycero-3-phosphocholine[erm] YML059C Glycerophospholipid metabolism +r_3031 LPC phospholipase B (16:1), ER membrane H2O[erm] + 1-acylglycerophosphocholine (16:1)[erm] => H+[erm] + palmitoleate[erm] + sn-glycero-3-phosphocholine[erm] YML059C Glycerophospholipid metabolism +r_3032 LPC phospholipase B (18:0), ER membrane H2O[erm] + 1-acylglycerophosphocholine (18:0)[erm] => H+[erm] + stearate[erm] + sn-glycero-3-phosphocholine[erm] YML059C Glycerophospholipid metabolism +r_3033 LPC phospholipase B (18:1), ER membrane H2O[erm] + 1-acylglycerophosphocholine (18:1)[erm] => H+[erm] + oleate[erm] + sn-glycero-3-phosphocholine[erm] YML059C Glycerophospholipid metabolism +r_3034 PC phospholipase B (1-16:0, 2-16:1), cell envelope phosphatidylcholine (1-16:0, 2-16:1)[ce] + H2O[ce] => H+[ce] + 1-acylglycerophosphocholine (16:0)[ce] + palmitoleate[ce] YMR008C Glycerophospholipid metabolism +r_3035 PC phospholipase B (1-16:1, 2-16:1), cell envelope H2O[ce] + phosphatidylcholine (1-16:1, 2-16:1)[ce] => H+[ce] + palmitoleate[ce] + 1-acylglycerophosphocholine (16:1)[ce] YMR008C Glycerophospholipid metabolism +r_3036 PC phospholipase B (1-18:0, 2-16:1), cell envelope H2O[ce] + phosphatidylcholine (1-18:0, 2-16:1)[ce] => H+[ce] + palmitoleate[ce] + 1-acylglycerophosphocholine (18:0)[ce] YMR008C Glycerophospholipid metabolism +r_3037 PC phospholipase B (1-18:1, 2-16:1), cell envelope H2O[ce] + phosphatidylcholine (1-18:1, 2-16:1)[ce] => H+[ce] + palmitoleate[ce] + 1-acylglycerophosphocholine (18:1)[ce] YMR008C Glycerophospholipid metabolism +r_3038 PC phospholipase B (1-16:0, 2-18:1), cell envelope H2O[ce] + phosphatidylcholine (1-16:0, 2-18:1)[ce] => H+[ce] + 1-acylglycerophosphocholine (16:0)[ce] + oleate[ce] YMR008C Glycerophospholipid metabolism +r_3039 PC phospholipase B (1-16:1, 2-18:1), cell envelope H2O[ce] + phosphatidylcholine (1-16:1, 2-18:1)[ce] => H+[ce] + 1-acylglycerophosphocholine (16:1)[ce] + oleate[ce] YMR008C Glycerophospholipid metabolism +r_3040 PC phospholipase B (1-18:0, 2-18:1), cell envelope H2O[ce] + phosphatidylcholine (1-18:0, 2-18:1)[ce] => H+[ce] + 1-acylglycerophosphocholine (18:0)[ce] + oleate[ce] YMR008C Glycerophospholipid metabolism +r_3041 PC phospholipase B (1-18:1, 2-18:1), cell envelope H2O[ce] + phosphatidylcholine (1-18:1, 2-18:1)[ce] => H+[ce] + 1-acylglycerophosphocholine (18:1)[ce] + oleate[ce] YMR008C Glycerophospholipid metabolism +r_3042 LPC phospholipase B (16:0), cell envelope H2O[ce] + 1-acylglycerophosphocholine (16:0)[ce] => H+[ce] + sn-glycero-3-phosphocholine[ce] + palmitate[ce] YMR008C Glycerophospholipid metabolism +r_3043 LPC phospholipase B (16:1), cell envelope H2O[ce] + 1-acylglycerophosphocholine (16:1)[ce] => H+[ce] + sn-glycero-3-phosphocholine[ce] + palmitoleate[ce] YMR008C Glycerophospholipid metabolism +r_3044 LPC phospholipase B (18:0), cell envelope H2O[ce] + 1-acylglycerophosphocholine (18:0)[ce] => H+[ce] + sn-glycero-3-phosphocholine[ce] + stearate[ce] YMR008C Glycerophospholipid metabolism +r_3045 LPC phospholipase B (18:1), cell envelope H2O[ce] + 1-acylglycerophosphocholine (18:1)[ce] => H+[ce] + sn-glycero-3-phosphocholine[ce] + oleate[ce] YMR008C Glycerophospholipid metabolism +r_3046 PE phospholipase B (1-16:0, 2-16:1), cell envelope H2O[ce] + phosphatidylethanolamine (1-16:0, 2-16:1)[ce] => H+[ce] + palmitoleate[ce] + 1-acylglycerophosphoethanolamine (16:0)[ce] YMR006C or YMR008C Glycerophospholipid metabolism +r_3047 PE phospholipase B (1-16:1, 2-16:1), cell envelope H2O[ce] + phosphatidylethanolamine (1-16:1, 2-16:1)[ce] => H+[ce] + palmitoleate[ce] + 1-acylglycerophosphoethanolamine (16:1)[ce] YMR006C or YMR008C Glycerophospholipid metabolism +r_3048 PE phospholipase B (1-18:0, 2-16:1), cell envelope H2O[ce] + phosphatidylethanolamine (1-18:0, 2-16:1)[ce] => H+[ce] + palmitoleate[ce] + 1-acylglycerophosphoethanolamine (18:0)[ce] YMR006C or YMR008C Glycerophospholipid metabolism +r_3049 PE phospholipase B (1-18:1, 2-16:1), cell envelope H2O[ce] + phosphatidylethanolamine (1-18:1, 2-16:1)[ce] => H+[ce] + palmitoleate[ce] + 1-acylglycerophosphoethanolamine (18:1)[ce] YMR006C or YMR008C Glycerophospholipid metabolism +r_3050 PE phospholipase B (1-16:0, 2-18:1), cell envelope H2O[ce] + phosphatidylethanolamine (1-16:0, 2-18:1)[ce] => H+[ce] + oleate[ce] + 1-acylglycerophosphoethanolamine (16:0)[ce] YMR006C or YMR008C Glycerophospholipid metabolism +r_3051 PE phospholipase B (1-16:1, 2-18:1), cell envelope H2O[ce] + phosphatidylethanolamine (1-16:1, 2-18:1)[ce] => H+[ce] + oleate[ce] + 1-acylglycerophosphoethanolamine (16:1)[ce] YMR006C or YMR008C Glycerophospholipid metabolism +r_3052 PE phospholipase B (1-18:0, 2-18:1), cell envelope H2O[ce] + phosphatidylethanolamine (1-18:0, 2-18:1)[ce] => H+[ce] + oleate[ce] + 1-acylglycerophosphoethanolamine (18:0)[ce] YMR006C or YMR008C Glycerophospholipid metabolism +r_3053 PE phospholipase B (1-18:1, 2-18:1), cell envelope H2O[ce] + phosphatidylethanolamine (1-18:1, 2-18:1)[ce] => H+[ce] + oleate[ce] + 1-acylglycerophosphoethanolamine (18:1)[ce] YMR006C or YMR008C Glycerophospholipid metabolism +r_3054 LPE phospholipase B (16:0), cell envelope H2O[ce] + 1-acylglycerophosphoethanolamine (16:0)[ce] => H+[ce] + palmitate[ce] + sn-glycero-3-phosphoethanolamine[ce] YMR006C or YMR008C Glycerophospholipid metabolism +r_3055 LPE phospholipase B (16:1), cell envelope H2O[ce] + 1-acylglycerophosphoethanolamine (16:1)[ce] => H+[ce] + palmitoleate[ce] + sn-glycero-3-phosphoethanolamine[ce] YMR006C or YMR008C Glycerophospholipid metabolism +r_3056 LPE phospholipase B (18:0), cell envelope H2O[ce] + 1-acylglycerophosphoethanolamine (18:0)[ce] => H+[ce] + stearate[ce] + sn-glycero-3-phosphoethanolamine[ce] YMR006C or YMR008C Glycerophospholipid metabolism +r_3057 LPE phospholipase B (18:1), cell envelope H2O[ce] + 1-acylglycerophosphoethanolamine (18:1)[ce] => H+[ce] + oleate[ce] + sn-glycero-3-phosphoethanolamine[ce] YMR006C or YMR008C Glycerophospholipid metabolism +r_3058 PS phospholipase B (1-16:0, 2-16:1), cell envelope H2O[ce] + phosphatidyl-L-serine (1-16:0, 2-16:1)[ce] => H+[ce] + palmitoleate[ce] + 1-acylglycerophosphoserine (16:0)[ce] YMR006C or YOL011W Glycerophospholipid metabolism +r_3059 PS phospholipase B (1-16:1, 2-16:1), cell envelope H2O[ce] + phosphatidyl-L-serine (1-16:1, 2-16:1)[ce] => H+[ce] + palmitoleate[ce] + 1-acylglycerophosphoserine (16:1)[ce] YMR006C or YOL011W Glycerophospholipid metabolism +r_3060 PS phospholipase B (1-18:0, 2-16:1), cell envelope H2O[ce] + phosphatidyl-L-serine (1-18:0, 2-16:1)[ce] => H+[ce] + palmitoleate[ce] + 1-acylglycerophosphoserine (18:0)[ce] YMR006C or YOL011W Glycerophospholipid metabolism +r_3061 PS phospholipase B (1-18:1, 2-16:1), cell envelope H2O[ce] + phosphatidyl-L-serine (1-18:1, 2-16:1)[ce] => H+[ce] + palmitoleate[ce] + 1-acylglycerophosphoserine (18:1)[ce] YMR006C or YOL011W Glycerophospholipid metabolism +r_3062 PS phospholipase B (1-16:0, 2-18:1), cell envelope H2O[ce] + phosphatidyl-L-serine (1-16:0, 2-18:1)[ce] => H+[ce] + oleate[ce] + 1-acylglycerophosphoserine (16:0)[ce] YMR006C or YOL011W Glycerophospholipid metabolism +r_3063 PS phospholipase B (1-16:1, 2-18:1), cell envelope H2O[ce] + phosphatidyl-L-serine (1-16:1, 2-18:1)[ce] => H+[ce] + oleate[ce] + 1-acylglycerophosphoserine (16:1)[ce] YMR006C or YOL011W Glycerophospholipid metabolism +r_3064 PS phospholipase B (1-18:0, 2-18:1), cell envelope H2O[ce] + phosphatidyl-L-serine (1-18:0, 2-18:1)[ce] => H+[ce] + oleate[ce] + 1-acylglycerophosphoserine (18:0)[ce] YMR006C or YOL011W Glycerophospholipid metabolism +r_3065 PS phospholipase B (1-18:1, 2-18:1), cell envelope H2O[ce] + phosphatidyl-L-serine (1-18:1, 2-18:1)[ce] => H+[ce] + oleate[ce] + 1-acylglycerophosphoserine (18:1)[ce] YMR006C or YOL011W Glycerophospholipid metabolism +r_3066 LPS phospholipase B (16:0), cell envelope H2O[ce] + 1-acylglycerophosphoserine (16:0)[ce] => H+[ce] + palmitate[ce] + sn-glycero-3-phosphoserine[ce] YMR006C or YOL011W Glycerophospholipid metabolism +r_3067 LPS phospholipase B (16:1), cell envelope H2O[ce] + 1-acylglycerophosphoserine (16:1)[ce] => H+[ce] + palmitoleate[ce] + sn-glycero-3-phosphoserine[ce] YMR006C or YOL011W Glycerophospholipid metabolism +r_3068 LPS phospholipase B (18:0), cell envelope H2O[ce] + 1-acylglycerophosphoserine (18:0)[ce] => H+[ce] + stearate[ce] + sn-glycero-3-phosphoserine[ce] YMR006C or YOL011W Glycerophospholipid metabolism +r_3069 LPS phospholipase B (18:1), cell envelope H2O[ce] + 1-acylglycerophosphoserine (18:1)[ce] => H+[ce] + oleate[ce] + sn-glycero-3-phosphoserine[ce] YMR006C or YOL011W Glycerophospholipid metabolism +r_3070 PI phospholipase B (1-16:0, 2-16:1), cell envelope 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-16:1)[ce] + H2O[ce] => H+[ce] + palmitoleate[ce] + 1-acylglycerophosphoinositol (16:0)[ce] YOL011W Glycerophospholipid metabolism +r_3071 PI phospholipase B (1-16:1, 2-16:1), cell envelope 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-16:1)[ce] + H2O[ce] => H+[ce] + palmitoleate[ce] + 1-acylglycerophosphoinositol (16:1)[ce] YOL011W Glycerophospholipid metabolism +r_3072 PI phospholipase B (1-18:0, 2-16:1), cell envelope 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-16:1)[ce] + H2O[ce] => H+[ce] + palmitoleate[ce] + 1-acylglycerophosphoinositol (18:0)[ce] YOL011W Glycerophospholipid metabolism +r_3073 PI phospholipase B (1-18:1, 2-16:1), cell envelope 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-16:1)[ce] + H2O[ce] => H+[ce] + palmitoleate[ce] + 1-acylglycerophosphoinositol (18:1)[ce] YOL011W Glycerophospholipid metabolism +r_3074 PI phospholipase B (1-16:0, 2-18:1), cell envelope 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-18:1)[ce] + H2O[ce] => H+[ce] + oleate[ce] + 1-acylglycerophosphoinositol (16:0)[ce] YOL011W Glycerophospholipid metabolism +r_3075 PI phospholipase B (1-16:1, 2-18:1), cell envelope 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-18:1)[ce] + H2O[ce] => H+[ce] + oleate[ce] + 1-acylglycerophosphoinositol (16:1)[ce] YOL011W Glycerophospholipid metabolism +r_3076 PI phospholipase B (1-18:0, 2-18:1), cell envelope 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-18:1)[ce] + H2O[ce] => H+[ce] + oleate[ce] + 1-acylglycerophosphoinositol (18:0)[ce] YOL011W Glycerophospholipid metabolism +r_3077 PI phospholipase B (1-18:1, 2-18:1), cell envelope 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-18:1)[ce] + H2O[ce] => H+[ce] + oleate[ce] + 1-acylglycerophosphoinositol (18:1)[ce] YOL011W Glycerophospholipid metabolism +r_3078 LPI phospholipase B (16:0), cell envelope H2O[ce] + 1-acylglycerophosphoinositol (16:0)[ce] => 2 H+[ce] + palmitate[ce] + 1-(sn-glycero-3-phospho)-1D-myo-inositol[ce] YOL011W Glycerophospholipid metabolism +r_3079 LPI phospholipase B (16:1), cell envelope H2O[ce] + 1-acylglycerophosphoinositol (16:1)[ce] => 2 H+[ce] + palmitoleate[ce] + 1-(sn-glycero-3-phospho)-1D-myo-inositol[ce] YOL011W Glycerophospholipid metabolism +r_3080 LPI phospholipase B (18:0), cell envelope H2O[ce] + 1-acylglycerophosphoinositol (18:0)[ce] => 2 H+[ce] + stearate[ce] + 1-(sn-glycero-3-phospho)-1D-myo-inositol[ce] YOL011W Glycerophospholipid metabolism +r_3081 LPI phospholipase B (18:1), cell envelope H2O[ce] + 1-acylglycerophosphoinositol (18:1)[ce] => 2 H+[ce] + oleate[ce] + 1-(sn-glycero-3-phospho)-1D-myo-inositol[ce] YOL011W Glycerophospholipid metabolism +r_3082 PI 4,5-P2 phospholipase C (1-16:0, 2-16:1), cytoplasm H2O[c] + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-16:0, 2-16:1)[c] => 6 H+[c] + diglyceride (1-16:0, 2-16:1)[c] + 1D-myo-inositol 1,4,5-trisphosphate[c] YPL268W Inositol phosphate metabolism +r_3083 PI 4,5-P2 phospholipase C (1-16:1, 2-16:1), cytoplasm H2O[c] + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-16:1, 2-16:1)[c] => 6 H+[c] + 1D-myo-inositol 1,4,5-trisphosphate[c] + diglyceride (1-16:1, 2-16:1)[c] YPL268W Inositol phosphate metabolism +r_3084 PI 4,5-P2 phospholipase C (1-18:0, 2-16:1), cytoplasm H2O[c] + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-18:0, 2-16:1)[c] => 6 H+[c] + 1D-myo-inositol 1,4,5-trisphosphate[c] + diglyceride (1-18:0, 2-16:1)[c] YPL268W Inositol phosphate metabolism +r_3085 PI 4,5-P2 phospholipase C (1-18:1, 2-16:1), cytoplasm H2O[c] + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-18:1, 2-16:1)[c] => 6 H+[c] + 1D-myo-inositol 1,4,5-trisphosphate[c] + diglyceride (1-18:1, 2-16:1)[c] YPL268W Inositol phosphate metabolism +r_3086 PI 4,5-P2 phospholipase C (1-16:0, 2-18:1), cytoplasm H2O[c] + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-16:0, 2-18:1)[c] => 6 H+[c] + 1D-myo-inositol 1,4,5-trisphosphate[c] + diglyceride (1-16:0, 2-18:1)[c] YPL268W Inositol phosphate metabolism +r_3087 PI 4,5-P2 phospholipase C (1-16:1, 2-18:1), cytoplasm H2O[c] + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-16:1, 2-18:1)[c] => 6 H+[c] + 1D-myo-inositol 1,4,5-trisphosphate[c] + diglyceride (1-16:1, 2-18:1)[c] YPL268W Inositol phosphate metabolism +r_3088 PI 4,5-P2 phospholipase C (1-18:0, 2-18:1), cytoplasm H2O[c] + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-18:0, 2-18:1)[c] => 6 H+[c] + 1D-myo-inositol 1,4,5-trisphosphate[c] + diglyceride (1-18:0, 2-18:1)[c] YPL268W Inositol phosphate metabolism +r_3089 PI 4,5-P2 phospholipase C (1-18:1, 2-18:1), cytoplasm H2O[c] + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-18:1, 2-18:1)[c] => 6 H+[c] + 1D-myo-inositol 1,4,5-trisphosphate[c] + diglyceride (1-18:1, 2-18:1)[c] YPL268W Inositol phosphate metabolism +r_3090 PI 4,5-P2 phospholipase C (1-16:0, 2-16:1), nucleus H2O[n] + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-16:0, 2-16:1)[n] => 1D-myo-inositol 1,4,5-trisphosphate[n] + 6 H+[n] + diglyceride (1-16:0, 2-16:1)[n] YPL268W Inositol phosphate metabolism +r_3091 PI 4,5-P2 phospholipase C (1-16:1, 2-16:1), nucleus H2O[n] + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-16:1, 2-16:1)[n] => 1D-myo-inositol 1,4,5-trisphosphate[n] + 6 H+[n] + diglyceride (1-16:1, 2-16:1)[n] YPL268W Inositol phosphate metabolism +r_3092 PI 4,5-P2 phospholipase C (1-18:0, 2-16:1), nucleus H2O[n] + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-18:0, 2-16:1)[n] => 1D-myo-inositol 1,4,5-trisphosphate[n] + 6 H+[n] + diglyceride (1-18:0, 2-16:1)[n] YPL268W Inositol phosphate metabolism +r_3093 PI 4,5-P2 phospholipase C (1-18:1, 2-16:1), nucleus H2O[n] + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-18:1, 2-16:1)[n] => 1D-myo-inositol 1,4,5-trisphosphate[n] + 6 H+[n] + diglyceride (1-18:1, 2-16:1)[n] YPL268W Inositol phosphate metabolism +r_3094 PI 4,5-P2 phospholipase C (1-16:0, 2-18:1), nucleus H2O[n] + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-16:0, 2-18:1)[n] => 1D-myo-inositol 1,4,5-trisphosphate[n] + 6 H+[n] + diglyceride (1-16:0, 2-18:1)[n] YPL268W Inositol phosphate metabolism +r_3095 PI 4,5-P2 phospholipase C (1-16:1, 2-18:1), nucleus H2O[n] + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-16:1, 2-18:1)[n] => 1D-myo-inositol 1,4,5-trisphosphate[n] + 6 H+[n] + diglyceride (1-16:1, 2-18:1)[n] YPL268W Inositol phosphate metabolism +r_3096 PI 4,5-P2 phospholipase C (1-18:0, 2-18:1), nucleus H2O[n] + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-18:0, 2-18:1)[n] => 1D-myo-inositol 1,4,5-trisphosphate[n] + 6 H+[n] + diglyceride (1-18:0, 2-18:1)[n] YPL268W Inositol phosphate metabolism +r_3097 PI 4,5-P2 phospholipase C (1-18:1, 2-18:1), nucleus H2O[n] + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-18:1, 2-18:1)[n] => 1D-myo-inositol 1,4,5-trisphosphate[n] + 6 H+[n] + diglyceride (1-18:1, 2-18:1)[n] YPL268W Inositol phosphate metabolism +r_3098 PG phospholipase C (1-16:0, 2-16:1), mitochondrial membrane H2O[mm] + phosphatidylglycerol (1-16:0, 2-16:1)[mm] => 2 H+[mm] + glycerol 3-phosphate[mm] + diglyceride (1-16:0, 2-16:1)[mm] YPL206C Glycerophospholipid metabolism +r_3099 PG phospholipase C (1-16:1, 2-16:1), mitochondrial membrane H2O[mm] + phosphatidylglycerol (1-16:1, 2-16:1)[mm] => 2 H+[mm] + glycerol 3-phosphate[mm] + diglyceride (1-16:1, 2-16:1)[mm] YPL206C Glycerophospholipid metabolism +r_3100 PG phospholipase C (1-18:0, 2-16:1), mitochondrial membrane H2O[mm] + phosphatidylglycerol (1-18:0, 2-16:1)[mm] => 2 H+[mm] + glycerol 3-phosphate[mm] + diglyceride (1-18:0, 2-16:1)[mm] YPL206C Glycerophospholipid metabolism +r_3101 PG phospholipase C (1-18:1, 2-16:1), mitochondrial membrane H2O[mm] + phosphatidylglycerol (1-18:1, 2-16:1)[mm] => 2 H+[mm] + glycerol 3-phosphate[mm] + diglyceride (1-18:1, 2-16:1)[mm] YPL206C Glycerophospholipid metabolism +r_3102 PG phospholipase C (1-16:0, 2-18:1), mitochondrial membrane H2O[mm] + phosphatidylglycerol (1-16:0, 2-18:1)[mm] => 2 H+[mm] + glycerol 3-phosphate[mm] + diglyceride (1-16:0, 2-18:1)[mm] YPL206C Glycerophospholipid metabolism +r_3103 PG phospholipase C (1-16:1, 2-18:1), mitochondrial membrane H2O[mm] + phosphatidylglycerol (1-16:1, 2-18:1)[mm] => 2 H+[mm] + glycerol 3-phosphate[mm] + diglyceride (1-16:1, 2-18:1)[mm] YPL206C Glycerophospholipid metabolism +r_3104 PC phospholipase D (1-16:0, 2-16:1), cell envelope H+[ce] + phosphatidylcholine (1-16:0, 2-16:1)[ce] + H2O[ce] => choline[ce] + phosphatidate (1-16:0, 2-16:1)[ce] YKR031C Glycerophospholipid metabolism +r_3105 PC phospholipase D (1-16:1, 2-16:1), cell envelope H+[ce] + H2O[ce] + phosphatidylcholine (1-16:1, 2-16:1)[ce] => choline[ce] + phosphatidate (1-16:1, 2-16:1)[ce] YKR031C Glycerophospholipid metabolism +r_3106 PC phospholipase D (1-18:0, 2-16:1), cell envelope H+[ce] + H2O[ce] + phosphatidylcholine (1-18:0, 2-16:1)[ce] => choline[ce] + phosphatidate (1-18:0, 2-16:1)[ce] YKR031C Glycerophospholipid metabolism +r_3107 PC phospholipase D (1-18:1, 2-16:1), cell envelope H+[ce] + H2O[ce] + phosphatidylcholine (1-18:1, 2-16:1)[ce] => choline[ce] + phosphatidate (1-18:1, 2-16:1)[ce] YKR031C Glycerophospholipid metabolism +r_3108 PC phospholipase D (1-16:0, 2-18:1), cell envelope H+[ce] + H2O[ce] + phosphatidylcholine (1-16:0, 2-18:1)[ce] => choline[ce] + phosphatidate (1-16:0, 2-18:1)[ce] YKR031C Glycerophospholipid metabolism +r_3109 PC phospholipase D (1-16:1, 2-18:1), cell envelope H+[ce] + H2O[ce] + phosphatidylcholine (1-16:1, 2-18:1)[ce] => choline[ce] + phosphatidate (1-16:1, 2-18:1)[ce] YKR031C Glycerophospholipid metabolism +r_3110 PC phospholipase D (1-18:0, 2-18:1), cell envelope H+[ce] + H2O[ce] + phosphatidylcholine (1-18:0, 2-18:1)[ce] => choline[ce] + phosphatidate (1-18:0, 2-18:1)[ce] YKR031C Glycerophospholipid metabolism +r_3111 PC phospholipase D (1-18:1, 2-18:1), cell envelope H+[ce] + H2O[ce] + phosphatidylcholine (1-18:1, 2-18:1)[ce] => choline[ce] + phosphatidate (1-18:1, 2-18:1)[ce] YKR031C Glycerophospholipid metabolism +r_3112 PI 3-P phosphatase (1-16:0, 2-16:1), cell envelope H2O[ce] + 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-16:0, 2-16:1)[ce] => 2 H+[ce] + 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-16:1)[ce] + phosphate[ce] YNL106C or YOR109W Inositol phosphate metabolism +r_3113 PI 3-P phosphatase (1-16:1, 2-16:1), cell envelope H2O[ce] + 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-16:1, 2-16:1)[ce] => 2 H+[ce] + 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-16:1)[ce] + phosphate[ce] YNL106C or YOR109W Inositol phosphate metabolism +r_3114 PI 3-P phosphatase (1-18:0, 2-16:1), cell envelope H2O[ce] + 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-18:0, 2-16:1)[ce] => 2 H+[ce] + 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-16:1)[ce] + phosphate[ce] YNL106C or YOR109W Inositol phosphate metabolism +r_3115 PI 3-P phosphatase (1-18:1, 2-16:1), cell envelope H2O[ce] + 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-18:1, 2-16:1)[ce] => 2 H+[ce] + 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-16:1)[ce] + phosphate[ce] YNL106C or YOR109W Inositol phosphate metabolism +r_3116 PI 3-P phosphatase (1-16:0, 2-18:1), cell envelope H2O[ce] + 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-16:0, 2-18:1)[ce] => 2 H+[ce] + 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-18:1)[ce] + phosphate[ce] YNL106C or YOR109W Inositol phosphate metabolism +r_3117 PI 3-P phosphatase (1-16:1, 2-18:1), cell envelope H2O[ce] + 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-16:1, 2-18:1)[ce] => 2 H+[ce] + 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-18:1)[ce] + phosphate[ce] YNL106C or YOR109W Inositol phosphate metabolism +r_3118 PI 3-P phosphatase (1-18:0, 2-18:1), cell envelope H2O[ce] + 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-18:0, 2-18:1)[ce] => 2 H+[ce] + 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-18:1)[ce] + phosphate[ce] YNL106C or YOR109W Inositol phosphate metabolism +r_3119 PI 3-P phosphatase (1-18:1, 2-18:1), cell envelope H2O[ce] + 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-18:1, 2-18:1)[ce] => 2 H+[ce] + 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-18:1)[ce] + phosphate[ce] YNL106C or YOR109W Inositol phosphate metabolism +r_3120 PI 3-P phosphatase (1-16:0, 2-16:1), cytoplasm H2O[c] + 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-16:0, 2-16:1)[c] => 2 H+[c] + phosphate[c] + 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-16:1)[c] YJR110W or YNL106C or YOR109W Inositol phosphate metabolism +r_3121 PI 3-P phosphatase (1-16:1, 2-16:1), cytoplasm H2O[c] + 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-16:1, 2-16:1)[c] => 2 H+[c] + phosphate[c] + 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-16:1)[c] YJR110W or YNL106C or YOR109W Inositol phosphate metabolism +r_3122 PI 3-P phosphatase (1-18:0, 2-16:1), cytoplasm H2O[c] + 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-18:0, 2-16:1)[c] => 2 H+[c] + phosphate[c] + 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-16:1)[c] YJR110W or YNL106C or YOR109W Inositol phosphate metabolism +r_3123 PI 3-P phosphatase (1-18:1, 2-16:1), cytoplasm H2O[c] + 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-18:1, 2-16:1)[c] => 2 H+[c] + phosphate[c] + 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-16:1)[c] YJR110W or YNL106C or YOR109W Inositol phosphate metabolism +r_3124 PI 3-P phosphatase (1-16:0, 2-18:1), cytoplasm H2O[c] + 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-16:0, 2-18:1)[c] => 2 H+[c] + phosphate[c] + 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-18:1)[c] YJR110W or YNL106C or YOR109W Inositol phosphate metabolism +r_3125 PI 3-P phosphatase (1-16:1, 2-18:1), cytoplasm H2O[c] + 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-16:1, 2-18:1)[c] => 2 H+[c] + phosphate[c] + 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-18:1)[c] YJR110W or YNL106C or YOR109W Inositol phosphate metabolism +r_3126 PI 3-P phosphatase (1-18:0, 2-18:1), cytoplasm H2O[c] + 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-18:0, 2-18:1)[c] => 2 H+[c] + phosphate[c] + 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-18:1)[c] YJR110W or YNL106C or YOR109W Inositol phosphate metabolism +r_3127 PI 3-P phosphatase (1-18:1, 2-18:1), cytoplasm H2O[c] + 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-18:1, 2-18:1)[c] => 2 H+[c] + phosphate[c] + 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-18:1)[c] YJR110W or YNL106C or YOR109W Inositol phosphate metabolism +r_3128 PI 3-P phosphatase (1-16:0, 2-16:1), ER membrane H2O[erm] + 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-16:0, 2-16:1)[erm] => 2 H+[erm] + phosphate[erm] + 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-16:1)[erm] YKL212W Inositol phosphate metabolism +r_3129 PI 3-P phosphatase (1-16:1, 2-16:1), ER membrane H2O[erm] + 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-16:1, 2-16:1)[erm] => 2 H+[erm] + phosphate[erm] + 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-16:1)[erm] YKL212W Inositol phosphate metabolism +r_3130 PI 3-P phosphatase (1-18:0, 2-16:1), ER membrane H2O[erm] + 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-18:0, 2-16:1)[erm] => 2 H+[erm] + phosphate[erm] + 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-16:1)[erm] YKL212W Inositol phosphate metabolism +r_3131 PI 3-P phosphatase (1-18:1, 2-16:1), ER membrane H2O[erm] + 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-18:1, 2-16:1)[erm] => 2 H+[erm] + phosphate[erm] + 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-16:1)[erm] YKL212W Inositol phosphate metabolism +r_3132 PI 3-P phosphatase (1-16:0, 2-18:1), ER membrane H2O[erm] + 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-16:0, 2-18:1)[erm] => 2 H+[erm] + phosphate[erm] + 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-18:1)[erm] YKL212W Inositol phosphate metabolism +r_3133 PI 3-P phosphatase (1-16:1, 2-18:1), ER membrane H2O[erm] + 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-16:1, 2-18:1)[erm] => 2 H+[erm] + phosphate[erm] + 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-18:1)[erm] YKL212W Inositol phosphate metabolism +r_3134 PI 3-P phosphatase (1-18:0, 2-18:1), ER membrane H2O[erm] + 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-18:0, 2-18:1)[erm] => 2 H+[erm] + phosphate[erm] + 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-18:1)[erm] YKL212W Inositol phosphate metabolism +r_3135 PI 3-P phosphatase (1-18:1, 2-18:1), ER membrane H2O[erm] + 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-18:1, 2-18:1)[erm] => 2 H+[erm] + phosphate[erm] + 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-18:1)[erm] YKL212W Inositol phosphate metabolism +r_3136 PI 3-P phosphatase (1-16:0, 2-16:1), Golgi membrane H2O[gm] + 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-16:0, 2-16:1)[gm] => phosphate[gm] + 2 H+[gm] + 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-16:1)[gm] YKL212W Inositol phosphate metabolism +r_3137 PI 3-P phosphatase (1-16:1, 2-16:1), Golgi membrane H2O[gm] + 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-16:1, 2-16:1)[gm] => phosphate[gm] + 2 H+[gm] + 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-16:1)[gm] YKL212W Inositol phosphate metabolism +r_3138 PI 3-P phosphatase (1-18:0, 2-16:1), Golgi membrane H2O[gm] + 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-18:0, 2-16:1)[gm] => phosphate[gm] + 2 H+[gm] + 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-16:1)[gm] YKL212W Inositol phosphate metabolism +r_3139 PI 3-P phosphatase (1-18:1, 2-16:1), Golgi membrane H2O[gm] + 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-18:1, 2-16:1)[gm] => phosphate[gm] + 2 H+[gm] + 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-16:1)[gm] YKL212W Inositol phosphate metabolism +r_3140 PI 3-P phosphatase (1-16:0, 2-18:1), Golgi membrane H2O[gm] + 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-16:0, 2-18:1)[gm] => phosphate[gm] + 2 H+[gm] + 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-18:1)[gm] YKL212W Inositol phosphate metabolism +r_3141 PI 3-P phosphatase (1-16:1, 2-18:1), Golgi membrane H2O[gm] + 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-16:1, 2-18:1)[gm] => phosphate[gm] + 2 H+[gm] + 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-18:1)[gm] YKL212W Inositol phosphate metabolism +r_3142 PI 3-P phosphatase (1-18:0, 2-18:1), Golgi membrane H2O[gm] + 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-18:0, 2-18:1)[gm] => phosphate[gm] + 2 H+[gm] + 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-18:1)[gm] YKL212W Inositol phosphate metabolism +r_3143 PI 3-P phosphatase (1-18:1, 2-18:1), Golgi membrane H2O[gm] + 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-18:1, 2-18:1)[gm] => phosphate[gm] + 2 H+[gm] + 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-18:1)[gm] YKL212W Inositol phosphate metabolism +r_3144 PI 4-P phosphatase (1-16:0, 2-16:1), cell envelope 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-16:0, 2-16:1)[ce] + H2O[ce] => 2 H+[ce] + 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-16:1)[ce] + phosphate[ce] YNL106C or YOR109W Inositol phosphate metabolism +r_3145 PI 4-P phosphatase (1-16:1, 2-16:1), cell envelope 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-16:1, 2-16:1)[ce] + H2O[ce] => 2 H+[ce] + 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-16:1)[ce] + phosphate[ce] YNL106C or YOR109W Inositol phosphate metabolism +r_3146 PI 4-P phosphatase (1-18:0, 2-16:1), cell envelope 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-18:0, 2-16:1)[ce] + H2O[ce] => 2 H+[ce] + 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-16:1)[ce] + phosphate[ce] YNL106C or YOR109W Inositol phosphate metabolism +r_3147 PI 4-P phosphatase (1-18:1, 2-16:1), cell envelope 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-18:1, 2-16:1)[ce] + H2O[ce] => 2 H+[ce] + 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-16:1)[ce] + phosphate[ce] YNL106C or YOR109W Inositol phosphate metabolism +r_3148 PI 4-P phosphatase (1-16:0, 2-18:1), cell envelope 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-16:0, 2-18:1)[ce] + H2O[ce] => 2 H+[ce] + 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-18:1)[ce] + phosphate[ce] YNL106C or YOR109W Inositol phosphate metabolism +r_3149 PI 4-P phosphatase (1-16:1, 2-18:1), cell envelope 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-16:1, 2-18:1)[ce] + H2O[ce] => 2 H+[ce] + 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-18:1)[ce] + phosphate[ce] YNL106C or YOR109W Inositol phosphate metabolism +r_3150 PI 4-P phosphatase (1-18:0, 2-18:1), cell envelope 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-18:0, 2-18:1)[ce] + H2O[ce] => 2 H+[ce] + 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-18:1)[ce] + phosphate[ce] YNL106C or YOR109W Inositol phosphate metabolism +r_3151 PI 4-P phosphatase (1-18:1, 2-18:1), cell envelope 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-18:1, 2-18:1)[ce] + H2O[ce] => 2 H+[ce] + 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-18:1)[ce] + phosphate[ce] YNL106C or YOR109W Inositol phosphate metabolism +r_3152 PI 4-P phosphatase (1-16:0, 2-16:1), cytoplasm H2O[c] + 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-16:0, 2-16:1)[c] => 2 H+[c] + phosphate[c] + 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-16:1)[c] YNL106C or YOR109W Inositol phosphate metabolism +r_3153 PI 4-P phosphatase (1-16:1, 2-16:1), cytoplasm H2O[c] + 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-16:1, 2-16:1)[c] => 2 H+[c] + phosphate[c] + 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-16:1)[c] YNL106C or YOR109W Inositol phosphate metabolism +r_3154 PI 4-P phosphatase (1-18:0, 2-16:1), cytoplasm H2O[c] + 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-18:0, 2-16:1)[c] => 2 H+[c] + phosphate[c] + 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-16:1)[c] YNL106C or YOR109W Inositol phosphate metabolism +r_3155 PI 4-P phosphatase (1-18:1, 2-16:1), cytoplasm H2O[c] + 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-18:1, 2-16:1)[c] => 2 H+[c] + phosphate[c] + 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-16:1)[c] YNL106C or YOR109W Inositol phosphate metabolism +r_3156 PI 4-P phosphatase (1-16:0, 2-18:1), cytoplasm H2O[c] + 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-16:0, 2-18:1)[c] => 2 H+[c] + phosphate[c] + 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-18:1)[c] YNL106C or YOR109W Inositol phosphate metabolism +r_3157 PI 4-P phosphatase (1-16:1, 2-18:1), cytoplasm H2O[c] + 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-16:1, 2-18:1)[c] => 2 H+[c] + phosphate[c] + 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-18:1)[c] YNL106C or YOR109W Inositol phosphate metabolism +r_3158 PI 4-P phosphatase (1-18:0, 2-18:1), cytoplasm H2O[c] + 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-18:0, 2-18:1)[c] => 2 H+[c] + phosphate[c] + 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-18:1)[c] YNL106C or YOR109W Inositol phosphate metabolism +r_3159 PI 4-P phosphatase (1-18:1, 2-18:1), cytoplasm H2O[c] + 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-18:1, 2-18:1)[c] => 2 H+[c] + phosphate[c] + 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-18:1)[c] YNL106C or YOR109W Inositol phosphate metabolism +r_3160 PI 4-P phosphatase (1-16:0, 2-16:1), ER membrane H2O[erm] + 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-16:0, 2-16:1)[erm] => 2 H+[erm] + phosphate[erm] + 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-16:1)[erm] YKL212W Inositol phosphate metabolism +r_3161 PI 4-P phosphatase (1-16:1, 2-16:1), ER membrane H2O[erm] + 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-16:1, 2-16:1)[erm] => 2 H+[erm] + phosphate[erm] + 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-16:1)[erm] YKL212W Inositol phosphate metabolism +r_3162 PI 4-P phosphatase (1-18:0, 2-16:1), ER membrane H2O[erm] + 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-18:0, 2-16:1)[erm] => 2 H+[erm] + phosphate[erm] + 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-16:1)[erm] YKL212W Inositol phosphate metabolism +r_3163 PI 4-P phosphatase (1-18:1, 2-16:1), ER membrane H2O[erm] + 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-18:1, 2-16:1)[erm] => 2 H+[erm] + phosphate[erm] + 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-16:1)[erm] YKL212W Inositol phosphate metabolism +r_3164 PI 4-P phosphatase (1-16:0, 2-18:1), ER membrane H2O[erm] + 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-16:0, 2-18:1)[erm] => 2 H+[erm] + phosphate[erm] + 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-18:1)[erm] YKL212W Inositol phosphate metabolism +r_3165 PI 4-P phosphatase (1-16:1, 2-18:1), ER membrane H2O[erm] + 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-16:1, 2-18:1)[erm] => 2 H+[erm] + phosphate[erm] + 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-18:1)[erm] YKL212W Inositol phosphate metabolism +r_3166 PI 4-P phosphatase (1-18:0, 2-18:1), ER membrane H2O[erm] + 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-18:0, 2-18:1)[erm] => 2 H+[erm] + phosphate[erm] + 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-18:1)[erm] YKL212W Inositol phosphate metabolism +r_3167 PI 4-P phosphatase (1-18:1, 2-18:1), ER membrane H2O[erm] + 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-18:1, 2-18:1)[erm] => 2 H+[erm] + phosphate[erm] + 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-18:1)[erm] YKL212W Inositol phosphate metabolism +r_3168 PI 4-P phosphatase (1-16:0, 2-16:1), Golgi membrane H2O[gm] + 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-16:0, 2-16:1)[gm] => phosphate[gm] + 2 H+[gm] + 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-16:1)[gm] YKL212W Inositol phosphate metabolism +r_3169 PI 4-P phosphatase (1-16:1, 2-16:1), Golgi membrane H2O[gm] + 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-16:1, 2-16:1)[gm] => phosphate[gm] + 2 H+[gm] + 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-16:1)[gm] YKL212W Inositol phosphate metabolism +r_3170 PI 4-P phosphatase (1-18:0, 2-16:1), Golgi membrane H2O[gm] + 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-18:0, 2-16:1)[gm] => phosphate[gm] + 2 H+[gm] + 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-16:1)[gm] YKL212W Inositol phosphate metabolism +r_3171 PI 4-P phosphatase (1-18:1, 2-16:1), Golgi membrane H2O[gm] + 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-18:1, 2-16:1)[gm] => phosphate[gm] + 2 H+[gm] + 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-16:1)[gm] YKL212W Inositol phosphate metabolism +r_3172 PI 4-P phosphatase (1-16:0, 2-18:1), Golgi membrane H2O[gm] + 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-16:0, 2-18:1)[gm] => phosphate[gm] + 2 H+[gm] + 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-18:1)[gm] YKL212W Inositol phosphate metabolism +r_3173 PI 4-P phosphatase (1-16:1, 2-18:1), Golgi membrane H2O[gm] + 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-16:1, 2-18:1)[gm] => phosphate[gm] + 2 H+[gm] + 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-18:1)[gm] YKL212W Inositol phosphate metabolism +r_3174 PI 4-P phosphatase (1-18:0, 2-18:1), Golgi membrane H2O[gm] + 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-18:0, 2-18:1)[gm] => phosphate[gm] + 2 H+[gm] + 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-18:1)[gm] YKL212W Inositol phosphate metabolism +r_3175 PI 4-P phosphatase (1-18:1, 2-18:1), Golgi membrane H2O[gm] + 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-18:1, 2-18:1)[gm] => phosphate[gm] + 2 H+[gm] + 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-18:1)[gm] YKL212W Inositol phosphate metabolism +r_3176 PI 3,5-P2 phosphatase (1-16:0, 2-16:1), cell envelope H2O[ce] + 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-16:0, 2-16:1)[ce] => 2 H+[ce] + 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-16:0, 2-16:1)[ce] + phosphate[ce] YNL106C or YOR109W Inositol phosphate metabolism +r_3177 PI 3,5-P2 phosphatase (1-16:1, 2-16:1), cell envelope H2O[ce] + 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-16:1, 2-16:1)[ce] => 2 H+[ce] + phosphate[ce] + 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-16:1, 2-16:1)[ce] YNL106C or YOR109W Inositol phosphate metabolism +r_3178 PI 3,5-P2 phosphatase (1-18:0, 2-16:1), cell envelope H2O[ce] + 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-18:0, 2-16:1)[ce] => 2 H+[ce] + phosphate[ce] + 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-18:0, 2-16:1)[ce] YNL106C or YOR109W Inositol phosphate metabolism +r_3179 PI 3,5-P2 phosphatase (1-18:1, 2-16:1), cell envelope H2O[ce] + 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-18:1, 2-16:1)[ce] => 2 H+[ce] + phosphate[ce] + 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-18:1, 2-16:1)[ce] YNL106C or YOR109W Inositol phosphate metabolism +r_3180 PI 3,5-P2 phosphatase (1-16:0, 2-18:1), cell envelope H2O[ce] + 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-16:0, 2-18:1)[ce] => 2 H+[ce] + phosphate[ce] + 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-16:0, 2-18:1)[ce] YNL106C or YOR109W Inositol phosphate metabolism +r_3181 PI 3,5-P2 phosphatase (1-16:1, 2-18:1), cell envelope H2O[ce] + 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-16:1, 2-18:1)[ce] => 2 H+[ce] + phosphate[ce] + 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-16:1, 2-18:1)[ce] YNL106C or YOR109W Inositol phosphate metabolism +r_3182 PI 3,5-P2 phosphatase (1-18:0, 2-18:1), cell envelope H2O[ce] + 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-18:0, 2-18:1)[ce] => 2 H+[ce] + phosphate[ce] + 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-18:0, 2-18:1)[ce] YNL106C or YOR109W Inositol phosphate metabolism +r_3183 PI 3,5-P2 phosphatase (1-18:1, 2-18:1), cell envelope H2O[ce] + 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-18:1, 2-18:1)[ce] => 2 H+[ce] + phosphate[ce] + 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-18:1, 2-18:1)[ce] YNL106C or YOR109W Inositol phosphate metabolism +r_3184 PI 3,5-P2 phosphatase (1-16:0, 2-16:1), cytoplasm H2O[c] + 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-16:0, 2-16:1)[c] => 2 H+[c] + phosphate[c] + 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-16:0, 2-16:1)[c] YNL106C or YOR109W Inositol phosphate metabolism +r_3185 PI 3,5-P2 phosphatase (1-16:1, 2-16:1), cytoplasm H2O[c] + 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-16:1, 2-16:1)[c] => 2 H+[c] + phosphate[c] + 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-16:1, 2-16:1)[c] YNL106C or YOR109W Inositol phosphate metabolism +r_3186 PI 3,5-P2 phosphatase (1-18:0, 2-16:1), cytoplasm H2O[c] + 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-18:0, 2-16:1)[c] => 2 H+[c] + phosphate[c] + 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-18:0, 2-16:1)[c] YNL106C or YOR109W Inositol phosphate metabolism +r_3187 PI 3,5-P2 phosphatase (1-18:1, 2-16:1), cytoplasm H2O[c] + 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-18:1, 2-16:1)[c] => 2 H+[c] + phosphate[c] + 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-18:1, 2-16:1)[c] YNL106C or YOR109W Inositol phosphate metabolism +r_3188 PI 3,5-P2 phosphatase (1-16:0, 2-18:1), cytoplasm H2O[c] + 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-16:0, 2-18:1)[c] => 2 H+[c] + phosphate[c] + 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-16:0, 2-18:1)[c] YNL106C or YOR109W Inositol phosphate metabolism +r_3189 PI 3,5-P2 phosphatase (1-16:1, 2-18:1), cytoplasm H2O[c] + 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-16:1, 2-18:1)[c] => 2 H+[c] + phosphate[c] + 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-16:1, 2-18:1)[c] YNL106C or YOR109W Inositol phosphate metabolism +r_3190 PI 3,5-P2 phosphatase (1-18:0, 2-18:1), cytoplasm H2O[c] + 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-18:0, 2-18:1)[c] => 2 H+[c] + phosphate[c] + 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-18:0, 2-18:1)[c] YNL106C or YOR109W Inositol phosphate metabolism +r_3191 PI 3,5-P2 phosphatase (1-18:1, 2-18:1), cytoplasm H2O[c] + 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-18:1, 2-18:1)[c] => 2 H+[c] + phosphate[c] + 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-18:1, 2-18:1)[c] YNL106C or YOR109W Inositol phosphate metabolism +r_3192 PI 4,5-P2 phosphatase (1-16:0, 2-16:1), cell envelope 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-16:0, 2-16:1)[ce] + H2O[ce] => 2 H+[ce] + 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-16:0, 2-16:1)[ce] + phosphate[ce] YIL002C or YNL106C or YOR109W Inositol phosphate metabolism +r_3193 PI 4,5-P2 phosphatase (1-16:1, 2-16:1), cell envelope 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-16:1, 2-16:1)[ce] + H2O[ce] => 2 H+[ce] + 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-16:1, 2-16:1)[ce] + phosphate[ce] YIL002C or YNL106C or YOR109W Inositol phosphate metabolism +r_3194 PI 4,5-P2 phosphatase (1-18:0, 2-16:1), cell envelope 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-18:0, 2-16:1)[ce] + H2O[ce] => 2 H+[ce] + 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-18:0, 2-16:1)[ce] + phosphate[ce] YIL002C or YNL106C or YOR109W Inositol phosphate metabolism +r_3195 PI 4,5-P2 phosphatase (1-18:1, 2-16:1), cell envelope 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-18:1, 2-16:1)[ce] + H2O[ce] => 2 H+[ce] + 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-18:1, 2-16:1)[ce] + phosphate[ce] YIL002C or YNL106C or YOR109W Inositol phosphate metabolism +r_3196 PI 4,5-P2 phosphatase (1-16:0, 2-18:1), cell envelope 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-16:0, 2-18:1)[ce] + H2O[ce] => 2 H+[ce] + 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-16:0, 2-18:1)[ce] + phosphate[ce] YIL002C or YNL106C or YOR109W Inositol phosphate metabolism +r_3197 PI 4,5-P2 phosphatase (1-16:1, 2-18:1), cell envelope 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-16:1, 2-18:1)[ce] + H2O[ce] => 2 H+[ce] + 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-16:1, 2-18:1)[ce] + phosphate[ce] YIL002C or YNL106C or YOR109W Inositol phosphate metabolism +r_3198 PI 4,5-P2 phosphatase (1-18:0, 2-18:1), cell envelope 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-18:0, 2-18:1)[ce] + H2O[ce] => 2 H+[ce] + 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-18:0, 2-18:1)[ce] + phosphate[ce] YIL002C or YNL106C or YOR109W Inositol phosphate metabolism +r_3199 PI 4,5-P2 phosphatase (1-18:1, 2-18:1), cell envelope 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-18:1, 2-18:1)[ce] + H2O[ce] => 2 H+[ce] + 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-18:1, 2-18:1)[ce] + phosphate[ce] YIL002C or YNL106C or YOR109W Inositol phosphate metabolism +r_3200 PI 4,5-P2 phosphatase (1-16:0, 2-16:1), cytoplasm H2O[c] + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-16:0, 2-16:1)[c] => 2 H+[c] + phosphate[c] + 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-16:0, 2-16:1)[c] YIL002C or YNL106C or YOR109W Inositol phosphate metabolism +r_3201 PI 4,5-P2 phosphatase (1-16:1, 2-16:1), cytoplasm H2O[c] + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-16:1, 2-16:1)[c] => 2 H+[c] + phosphate[c] + 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-16:1, 2-16:1)[c] YIL002C or YNL106C or YOR109W Inositol phosphate metabolism +r_3202 PI 4,5-P2 phosphatase (1-18:0, 2-16:1), cytoplasm H2O[c] + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-18:0, 2-16:1)[c] => 2 H+[c] + phosphate[c] + 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-18:0, 2-16:1)[c] YIL002C or YNL106C or YOR109W Inositol phosphate metabolism +r_3203 PI 4,5-P2 phosphatase (1-18:1, 2-16:1), cytoplasm H2O[c] + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-18:1, 2-16:1)[c] => 2 H+[c] + phosphate[c] + 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-18:1, 2-16:1)[c] YIL002C or YNL106C or YOR109W Inositol phosphate metabolism +r_3204 PI 4,5-P2 phosphatase (1-16:0, 2-18:1), cytoplasm H2O[c] + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-16:0, 2-18:1)[c] => 2 H+[c] + phosphate[c] + 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-16:0, 2-18:1)[c] YIL002C or YNL106C or YOR109W Inositol phosphate metabolism +r_3205 PI 4,5-P2 phosphatase (1-16:1, 2-18:1), cytoplasm H2O[c] + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-16:1, 2-18:1)[c] => 2 H+[c] + phosphate[c] + 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-16:1, 2-18:1)[c] YIL002C or YNL106C or YOR109W Inositol phosphate metabolism +r_3206 PI 4,5-P2 phosphatase (1-18:0, 2-18:1), cytoplasm H2O[c] + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-18:0, 2-18:1)[c] => 2 H+[c] + phosphate[c] + 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-18:0, 2-18:1)[c] YIL002C or YNL106C or YOR109W Inositol phosphate metabolism +r_3207 PI 4,5-P2 phosphatase (1-18:1, 2-18:1), cytoplasm H2O[c] + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-18:1, 2-18:1)[c] => 2 H+[c] + phosphate[c] + 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-18:1, 2-18:1)[c] YIL002C or YNL106C or YOR109W Inositol phosphate metabolism +r_3208 PI 4,5-P2 phosphatase (1-16:0, 2-16:1), ER membrane H2O[erm] + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-16:0, 2-16:1)[erm] => 2 H+[erm] + phosphate[erm] + 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-16:0, 2-16:1)[erm] YOL065C Inositol phosphate metabolism +r_3209 PI 4,5-P2 phosphatase (1-16:1, 2-16:1), ER membrane H2O[erm] + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-16:1, 2-16:1)[erm] => 2 H+[erm] + phosphate[erm] + 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-16:1, 2-16:1)[erm] YOL065C Inositol phosphate metabolism +r_3210 PI 4,5-P2 phosphatase (1-18:0, 2-16:1), ER membrane H2O[erm] + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-18:0, 2-16:1)[erm] => 2 H+[erm] + phosphate[erm] + 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-18:0, 2-16:1)[erm] YOL065C Inositol phosphate metabolism +r_3211 PI 4,5-P2 phosphatase (1-18:1, 2-16:1), ER membrane H2O[erm] + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-18:1, 2-16:1)[erm] => 2 H+[erm] + phosphate[erm] + 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-18:1, 2-16:1)[erm] YOL065C Inositol phosphate metabolism +r_3212 PI 4,5-P2 phosphatase (1-16:0, 2-18:1), ER membrane H2O[erm] + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-16:0, 2-18:1)[erm] => 2 H+[erm] + phosphate[erm] + 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-16:0, 2-18:1)[erm] YOL065C Inositol phosphate metabolism +r_3213 PI 4,5-P2 phosphatase (1-16:1, 2-18:1), ER membrane H2O[erm] + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-16:1, 2-18:1)[erm] => 2 H+[erm] + phosphate[erm] + 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-16:1, 2-18:1)[erm] YOL065C Inositol phosphate metabolism +r_3214 PI 4,5-P2 phosphatase (1-18:0, 2-18:1), ER membrane H2O[erm] + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-18:0, 2-18:1)[erm] => 2 H+[erm] + phosphate[erm] + 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-18:0, 2-18:1)[erm] YOL065C Inositol phosphate metabolism +r_3215 PI 4,5-P2 phosphatase (1-18:1, 2-18:1), ER membrane H2O[erm] + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-18:1, 2-18:1)[erm] => 2 H+[erm] + phosphate[erm] + 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-18:1, 2-18:1)[erm] YOL065C Inositol phosphate metabolism +r_3216 PI 3,5-P2 phosphatase (1-16:0, 2-16:1), vacuolar membrane H2O[vm] + 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-16:0, 2-16:1)[vm] => phosphate[vm] + 2 H+[vm] + 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-16:0, 2-16:1)[vm] YLR386W and YNL325C Inositol phosphate metabolism +r_3217 PI 3,5-P2 phosphatase (1-16:1, 2-16:1), vacuolar membrane H2O[vm] + 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-16:1, 2-16:1)[vm] => phosphate[vm] + 2 H+[vm] + 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-16:1, 2-16:1)[vm] YLR386W and YNL325C Inositol phosphate metabolism +r_3218 PI 3,5-P2 phosphatase (1-18:0, 2-16:1), vacuolar membrane H2O[vm] + 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-18:0, 2-16:1)[vm] => phosphate[vm] + 2 H+[vm] + 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-18:0, 2-16:1)[vm] YLR386W and YNL325C Inositol phosphate metabolism +r_3219 PI 3,5-P2 phosphatase (1-18:1, 2-16:1), vacuolar membrane H2O[vm] + 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-18:1, 2-16:1)[vm] => phosphate[vm] + 2 H+[vm] + 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-18:1, 2-16:1)[vm] YLR386W and YNL325C Inositol phosphate metabolism +r_3220 PI 3,5-P2 phosphatase (1-16:0, 2-18:1), vacuolar membrane H2O[vm] + 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-16:0, 2-18:1)[vm] => phosphate[vm] + 2 H+[vm] + 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-16:0, 2-18:1)[vm] YLR386W and YNL325C Inositol phosphate metabolism +r_3221 PI 3,5-P2 phosphatase (1-16:1, 2-18:1), vacuolar membrane H2O[vm] + 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-16:1, 2-18:1)[vm] => phosphate[vm] + 2 H+[vm] + 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-16:1, 2-18:1)[vm] YLR386W and YNL325C Inositol phosphate metabolism +r_3222 PI 3,5-P2 phosphatase (1-18:0, 2-18:1), vacuolar membrane H2O[vm] + 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-18:0, 2-18:1)[vm] => phosphate[vm] + 2 H+[vm] + 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-18:0, 2-18:1)[vm] YLR386W and YNL325C Inositol phosphate metabolism +r_3223 PI 3,5-P2 phosphatase (1-18:1, 2-18:1), vacuolar membrane H2O[vm] + 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-18:1, 2-18:1)[vm] => phosphate[vm] + 2 H+[vm] + 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-18:1, 2-18:1)[vm] YLR386W and YNL325C Inositol phosphate metabolism +r_3224 DGPP phosphatase (1-16:0, 2-16:1), vacuolar membrane H2O[vm] + 1,2-diacylglycerol 3-diphosphate (1-16:0, 2-16:1)[vm] => phosphatidate (1-16:0, 2-16:1)[vm] + phosphate[vm] + 2 H+[vm] YDR284C Glycerolipid metabolism +r_3225 DGPP phosphatase (1-16:1, 2-16:1), vacuolar membrane H2O[vm] + 1,2-diacylglycerol 3-diphosphate (1-16:1, 2-16:1)[vm] => phosphate[vm] + phosphatidate (1-16:1, 2-16:1)[vm] + 2 H+[vm] YDR284C Glycerolipid metabolism +r_3226 DGPP phosphatase (1-18:0, 2-16:1), vacuolar membrane H2O[vm] + 1,2-diacylglycerol 3-diphosphate (1-18:0, 2-16:1)[vm] => phosphate[vm] + phosphatidate (1-18:0, 2-16:1)[vm] + 2 H+[vm] YDR284C Glycerolipid metabolism +r_3227 DGPP phosphatase (1-18:1, 2-16:1), vacuolar membrane H2O[vm] + 1,2-diacylglycerol 3-diphosphate (1-18:1, 2-16:1)[vm] => phosphate[vm] + phosphatidate (1-18:1, 2-16:1)[vm] + 2 H+[vm] YDR284C Glycerolipid metabolism +r_3228 DGPP phosphatase (1-16:0, 2-18:1), vacuolar membrane H2O[vm] + 1,2-diacylglycerol 3-diphosphate (1-16:0, 2-18:1)[vm] => phosphate[vm] + phosphatidate (1-16:0, 2-18:1)[vm] + 2 H+[vm] YDR284C Glycerolipid metabolism +r_3229 DGPP phosphatase (1-16:1, 2-18:1), vacuolar membrane H2O[vm] + 1,2-diacylglycerol 3-diphosphate (1-16:1, 2-18:1)[vm] => phosphate[vm] + phosphatidate (1-16:1, 2-18:1)[vm] + 2 H+[vm] YDR284C Glycerolipid metabolism +r_3230 DGPP phosphatase (1-18:0, 2-18:1), vacuolar membrane H2O[vm] + 1,2-diacylglycerol 3-diphosphate (1-18:0, 2-18:1)[vm] => phosphate[vm] + phosphatidate (1-18:0, 2-18:1)[vm] + 2 H+[vm] YDR284C Glycerolipid metabolism +r_3231 DGPP phosphatase (1-18:1, 2-18:1), vacuolar membrane H2O[vm] + 1,2-diacylglycerol 3-diphosphate (1-18:1, 2-18:1)[vm] => phosphate[vm] + phosphatidate (1-18:1, 2-18:1)[vm] + 2 H+[vm] YDR284C Glycerolipid metabolism +r_3232 DGPP phosphatase (1-16:0, 2-16:1), Golgi membrane H2O[gm] + 1,2-diacylglycerol 3-diphosphate (1-16:0, 2-16:1)[gm] => phosphatidate (1-16:0, 2-16:1)[gm] + phosphate[gm] + 2 H+[gm] YDR503C Glycerolipid metabolism +r_3233 DGPP phosphatase (1-16:1, 2-16:1), Golgi membrane H2O[gm] + 1,2-diacylglycerol 3-diphosphate (1-16:1, 2-16:1)[gm] => phosphate[gm] + phosphatidate (1-16:1, 2-16:1)[gm] + 2 H+[gm] YDR503C Glycerolipid metabolism +r_3234 DGPP phosphatase (1-18:0, 2-16:1), Golgi membrane H2O[gm] + 1,2-diacylglycerol 3-diphosphate (1-18:0, 2-16:1)[gm] => phosphate[gm] + phosphatidate (1-18:0, 2-16:1)[gm] + 2 H+[gm] YDR503C Glycerolipid metabolism +r_3235 DGPP phosphatase (1-18:1, 2-16:1), Golgi membrane H2O[gm] + 1,2-diacylglycerol 3-diphosphate (1-18:1, 2-16:1)[gm] => phosphate[gm] + phosphatidate (1-18:1, 2-16:1)[gm] + 2 H+[gm] YDR503C Glycerolipid metabolism +r_3236 DGPP phosphatase (1-16:0, 2-18:1), Golgi membrane H2O[gm] + 1,2-diacylglycerol 3-diphosphate (1-16:0, 2-18:1)[gm] => phosphate[gm] + phosphatidate (1-16:0, 2-18:1)[gm] + 2 H+[gm] YDR503C Glycerolipid metabolism +r_3237 DGPP phosphatase (1-16:1, 2-18:1), Golgi membrane H2O[gm] + 1,2-diacylglycerol 3-diphosphate (1-16:1, 2-18:1)[gm] => phosphate[gm] + phosphatidate (1-16:1, 2-18:1)[gm] + 2 H+[gm] YDR503C Glycerolipid metabolism +r_3238 DGPP phosphatase (1-18:0, 2-18:1), Golgi membrane H2O[gm] + 1,2-diacylglycerol 3-diphosphate (1-18:0, 2-18:1)[gm] => phosphate[gm] + phosphatidate (1-18:0, 2-18:1)[gm] + 2 H+[gm] YDR503C Glycerolipid metabolism +r_3239 DGPP phosphatase (1-18:1, 2-18:1), Golgi membrane H2O[gm] + 1,2-diacylglycerol 3-diphosphate (1-18:1, 2-18:1)[gm] => phosphate[gm] + phosphatidate (1-18:1, 2-18:1)[gm] + 2 H+[gm] YDR503C Glycerolipid metabolism +r_3240 lysoPA phosphatase (16:0), cytoplasm H2O[c] + 1-acyl-sn-glycerol 3-phosphate (16:0)[c] => 2 H+[c] + phosphate[c] + 1-monoglyceride (16:0)[c] YER037W Glycerolipid metabolism +r_3241 lysoPA phosphatase (16:1), cytoplasm H2O[c] + 1-acyl-sn-glycerol 3-phosphate (16:1)[c] => 2 H+[c] + phosphate[c] + 1-monoglyceride (16:1)[c] YER037W Glycerolipid metabolism +r_3242 lysoPA phosphatase (18:0), cytoplasm H2O[c] + 1-acyl-sn-glycerol 3-phosphate (18:0)[c] => 2 H+[c] + phosphate[c] + 1-monoglyceride (18:0)[c] YER037W Glycerolipid metabolism +r_3243 lysoPA phosphatase (18:1), cytoplasm H2O[c] + 1-acyl-sn-glycerol 3-phosphate (18:1)[c] => 2 H+[c] + phosphate[c] + 1-monoglyceride (18:1)[c] YER037W Glycerolipid metabolism +r_3244 lysoPA phosphatase (16:0), vacuolar membrane H2O[vm] + 1-acyl-sn-glycerol 3-phosphate (16:0)[vm] => phosphate[vm] + 2 H+[vm] + 1-monoglyceride (16:0)[vm] YDR284C Glycerolipid metabolism +r_3245 lysoPA phosphatase (16:1), vacuolar membrane H2O[vm] + 1-acyl-sn-glycerol 3-phosphate (16:1)[vm] => phosphate[vm] + 2 H+[vm] + 1-monoglyceride (16:1)[vm] YDR284C Glycerolipid metabolism +r_3246 lysoPA phosphatase (18:0), vacuolar membrane H2O[vm] + 1-acyl-sn-glycerol 3-phosphate (18:0)[vm] => phosphate[vm] + 2 H+[vm] + 1-monoglyceride (18:0)[vm] YDR284C Glycerolipid metabolism +r_3247 lysoPA phosphatase (18:1), vacuolar membrane H2O[vm] + 1-acyl-sn-glycerol 3-phosphate (18:1)[vm] => phosphate[vm] + 2 H+[vm] + 1-monoglyceride (18:1)[vm] YDR284C Glycerolipid metabolism +r_3248 lysoPA phosphatase (16:0), Golgi membrane H2O[gm] + 1-acyl-sn-glycerol 3-phosphate (16:0)[gm] => phosphate[gm] + 2 H+[gm] + 1-monoglyceride (16:0)[gm] YDR503C Glycerolipid metabolism +r_3249 lysoPA phosphatase (16:1), Golgi membrane H2O[gm] + 1-acyl-sn-glycerol 3-phosphate (16:1)[gm] => phosphate[gm] + 2 H+[gm] + 1-monoglyceride (16:1)[gm] YDR503C Glycerolipid metabolism +r_3250 lysoPA phosphatase (18:0), Golgi membrane H2O[gm] + 1-acyl-sn-glycerol 3-phosphate (18:0)[gm] => phosphate[gm] + 2 H+[gm] + 1-monoglyceride (18:0)[gm] YDR503C Glycerolipid metabolism +r_3251 lysoPA phosphatase (18:1), Golgi membrane H2O[gm] + 1-acyl-sn-glycerol 3-phosphate (18:1)[gm] => phosphate[gm] + 2 H+[gm] + 1-monoglyceride (18:1)[gm] YDR503C Glycerolipid metabolism +r_3252 ergosteryl ester hydrolase (16:1), lipid particle ergosteryl palmitoleate[lp] + H2O[lp] => ergosterol[lp] + H+[lp] + palmitoleate[lp] YKL140W or YLL012W Steroid biosynthesis +r_3253 ergosteryl ester hydrolase (18:1), lipid particle H2O[lp] + ergosteryl oleate[lp] => ergosterol[lp] + H+[lp] + oleate[lp] YKL140W or YLL012W Steroid biosynthesis +r_3254 episteryl ester hydrolase (16:1), lipid particle H2O[lp] + episteryl palmitoleate[lp] => H+[lp] + palmitoleate[lp] + episterol[lp] YLL012W Steroid biosynthesis +r_3255 episteryl ester hydrolase (18:1), lipid particle H2O[lp] + episteryl oleate[lp] => H+[lp] + oleate[lp] + episterol[lp] YLL012W Steroid biosynthesis +r_3256 fecosteryl ester hydrolase (16:1), lipid particle H2O[lp] + fecosteryl palmitoleate[lp] => fecosterol[lp] + H+[lp] + palmitoleate[lp] YLL012W Steroid biosynthesis +r_3257 fecosteryl ester hydrolase (18:1), lipid particle H2O[lp] + fecosteryl oleate[lp] => fecosterol[lp] + H+[lp] + oleate[lp] YLL012W Steroid biosynthesis +r_3258 lanosteryl ester hydrolase (16:1), lipid particle H2O[lp] + lanosteryl palmitoleate[lp] => H+[lp] + palmitoleate[lp] + lanosterol[lp] YLL012W Steroid biosynthesis +r_3259 lanosteryl ester hydrolase (18:1), lipid particle H2O[lp] + lanosteryl oleate[lp] => H+[lp] + oleate[lp] + lanosterol[lp] YLL012W Steroid biosynthesis +r_3260 zymosteryl ester hydrolase (16:1), lipid particle H2O[lp] + zymosteryl palmitoleate[lp] => H+[lp] + zymosterol[lp] + palmitoleate[lp] YLL012W Steroid biosynthesis +r_3261 zymosteryl ester hydrolase (18:1), lipid particle H2O[lp] + zymosteryl oleate[lp] => H+[lp] + zymosterol[lp] + oleate[lp] YLL012W Steroid biosynthesis +r_3262 zymosteryl ester hydrolase (16:1), cell envelope H2O[ce] + zymosteryl palmitoleate[ce] => H+[ce] + zymosterol[ce] + palmitoleate[ce] YLR020C Steroid biosynthesis +r_3263 zymosteryl ester hydrolase (18:1), cell envelope H2O[ce] + zymosteryl oleate[ce] => H+[ce] + zymosterol[ce] + oleate[ce] YLR020C Steroid biosynthesis +r_3264 TAG lipase (1-16:0, 2-16:1, 3-16:0), lipid particle triglyceride (1-16:0, 2-16:1, 3-16:0)[lp] + H2O[lp] => H+[lp] + palmitate[lp] + diglyceride (1-16:0, 2-16:1)[lp] YBR204C or YKR089C or YMR313C or YOR081C or YCR068W Glycerolipid metabolism +r_3265 TAG lipase (1-16:0, 2-16:1, 3-16:1), lipid particle triglyceride (1-16:0, 2-16:1, 3-16:1)[lp] + H2O[lp] => H+[lp] + palmitoleate[lp] + diglyceride (1-16:0, 2-16:1)[lp] YBR204C or YKR089C or YMR313C or YOR081C Glycerolipid metabolism +r_3266 TAG lipase (1-16:0, 2-16:1, 3-18:0), lipid particle triglyceride (1-16:0, 2-16:1, 3-18:0)[lp] + H2O[lp] => H+[lp] + stearate[lp] + diglyceride (1-16:0, 2-16:1)[lp] YBR204C or YKR089C or YMR313C or YOR081C Glycerolipid metabolism +r_3267 TAG lipase (1-16:0, 2-16:1, 3-18:1), lipid particle triglyceride (1-16:0, 2-16:1, 3-18:1)[lp] + H2O[lp] => H+[lp] + oleate[lp] + diglyceride (1-16:0, 2-16:1)[lp] YBR204C or YKR089C or YMR313C or YOR081C Glycerolipid metabolism +r_3268 TAG lipase (1-16:1, 2-16:1, 3-16:0), lipid particle triglyceride (1-16:1, 2-16:1, 3-16:0)[lp] + H2O[lp] => H+[lp] + palmitate[lp] + diglyceride (1-16:1, 2-16:1)[lp] YBR204C or YKR089C or YMR313C or YOR081C Glycerolipid metabolism +r_3269 TAG lipase (1-16:1, 2-16:1, 3-16:1), lipid particle triglyceride (1-16:1, 2-16:1, 3-16:1)[lp] + H2O[lp] => H+[lp] + palmitoleate[lp] + diglyceride (1-16:1, 2-16:1)[lp] YBR204C or YKR089C or YMR313C or YOR081C Glycerolipid metabolism +r_3270 TAG lipase (1-16:1, 2-16:1, 3-18:0), lipid particle triglyceride (1-16:1, 2-16:1, 3-18:0)[lp] + H2O[lp] => H+[lp] + stearate[lp] + diglyceride (1-16:1, 2-16:1)[lp] YBR204C or YKR089C or YMR313C or YOR081C Glycerolipid metabolism +r_3271 TAG lipase (1-16:1, 2-16:1, 3-18:1), lipid particle triglyceride (1-16:1, 2-16:1, 3-18:1)[lp] + H2O[lp] => H+[lp] + oleate[lp] + diglyceride (1-16:1, 2-16:1)[lp] YBR204C or YKR089C or YMR313C or YOR081C Glycerolipid metabolism +r_3272 TAG lipase (1-18:0, 2-16:1, 3-16:0), lipid particle triglyceride (1-18:0, 2-16:1, 3-16:0)[lp] + H2O[lp] => H+[lp] + palmitate[lp] + diglyceride (1-18:0, 2-16:1)[lp] YBR204C or YKR089C or YMR313C or YOR081C Glycerolipid metabolism +r_3273 TAG lipase (1-18:0, 2-16:1, 3-16:1), lipid particle triglyceride (1-18:0, 2-16:1, 3-16:1)[lp] + H2O[lp] => H+[lp] + palmitoleate[lp] + diglyceride (1-18:0, 2-16:1)[lp] YBR204C or YKR089C or YMR313C or YOR081C Glycerolipid metabolism +r_3274 TAG lipase (1-18:0, 2-16:1, 3-18:0), lipid particle triglyceride (1-18:0, 2-16:1, 3-18:0)[lp] + H2O[lp] => H+[lp] + stearate[lp] + diglyceride (1-18:0, 2-16:1)[lp] YBR204C or YKR089C or YMR313C or YOR081C Glycerolipid metabolism +r_3275 TAG lipase (1-18:0, 2-16:1, 3-18:1), lipid particle triglyceride (1-18:0, 2-16:1, 3-18:1)[lp] + H2O[lp] => H+[lp] + oleate[lp] + diglyceride (1-18:0, 2-16:1)[lp] YBR204C or YKR089C or YMR313C or YOR081C Glycerolipid metabolism +r_3276 TAG lipase (1-18:1, 2-16:1, 3-16:0), lipid particle triglyceride (1-18:1, 2-16:1, 3-16:0)[lp] + H2O[lp] => H+[lp] + palmitate[lp] + diglyceride (1-18:1, 2-16:1)[lp] YBR204C or YKR089C or YMR313C or YOR081C Glycerolipid metabolism +r_3277 TAG lipase (1-18:1, 2-16:1, 3-16:1), lipid particle triglyceride (1-18:1, 2-16:1, 3-16:1)[lp] + H2O[lp] => H+[lp] + palmitoleate[lp] + diglyceride (1-18:1, 2-16:1)[lp] YBR204C or YKR089C or YMR313C or YOR081C Glycerolipid metabolism +r_3278 TAG lipase (1-18:1, 2-16:1, 3-18:0), lipid particle triglyceride (1-18:1, 2-16:1, 3-18:0)[lp] + H2O[lp] => H+[lp] + stearate[lp] + diglyceride (1-18:1, 2-16:1)[lp] YBR204C or YKR089C or YMR313C or YOR081C Glycerolipid metabolism +r_3279 TAG lipase (1-18:1, 2-16:1, 3-18:1), lipid particle triglyceride (1-18:1, 2-16:1, 3-18:1)[lp] + H2O[lp] => H+[lp] + oleate[lp] + diglyceride (1-18:1, 2-16:1)[lp] YBR204C or YKR089C or YMR313C or YOR081C Glycerolipid metabolism +r_3280 TAG lipase (1-16:0, 2-18:1, 3-16:0), lipid particle triglyceride (1-16:0, 2-18:1, 3-16:0)[lp] + H2O[lp] => H+[lp] + palmitate[lp] + diglyceride (1-16:0, 2-18:1)[lp] YBR204C or YKR089C or YMR313C or YOR081C Glycerolipid metabolism +r_3281 TAG lipase (1-16:0, 2-18:1, 3-16:1), lipid particle triglyceride (1-16:0, 2-18:1, 3-16:1)[lp] + H2O[lp] => H+[lp] + palmitoleate[lp] + diglyceride (1-16:0, 2-18:1)[lp] YBR204C or YKR089C or YMR313C or YOR081C Glycerolipid metabolism +r_3282 TAG lipase (1-16:0, 2-18:1, 3-18:0), lipid particle triglyceride (1-16:0, 2-18:1, 3-18:0)[lp] + H2O[lp] => H+[lp] + stearate[lp] + diglyceride (1-16:0, 2-18:1)[lp] YBR204C or YKR089C or YMR313C or YOR081C Glycerolipid metabolism +r_3283 TAG lipase (1-16:0, 2-18:1, 3-18:1), lipid particle triglyceride (1-16:0, 2-18:1, 3-18:1)[lp] + H2O[lp] => H+[lp] + oleate[lp] + diglyceride (1-16:0, 2-18:1)[lp] YBR204C or YKR089C or YMR313C or YOR081C Glycerolipid metabolism +r_3284 TAG lipase (1-16:1, 2-18:1, 3-16:0), lipid particle triglyceride (1-16:1, 2-18:1, 3-16:0)[lp] + H2O[lp] => H+[lp] + palmitate[lp] + diglyceride (1-16:1, 2-18:1)[lp] YBR204C or YKR089C or YMR313C or YOR081C Glycerolipid metabolism +r_3285 TAG lipase (1-16:1, 2-18:1, 3-16:1), lipid particle triglyceride (1-16:1, 2-18:1, 3-16:1)[lp] + H2O[lp] => H+[lp] + palmitoleate[lp] + diglyceride (1-16:1, 2-18:1)[lp] YBR204C or YKR089C or YMR313C or YOR081C Glycerolipid metabolism +r_3286 TAG lipase (1-16:1, 2-18:1, 3-18:0), lipid particle triglyceride (1-16:1, 2-18:1, 3-18:0)[lp] + H2O[lp] => H+[lp] + stearate[lp] + diglyceride (1-16:1, 2-18:1)[lp] YBR204C or YKR089C or YMR313C or YOR081C Glycerolipid metabolism +r_3287 TAG lipase (1-16:1, 2-18:1, 3-18:1), lipid particle triglyceride (1-16:1, 2-18:1, 3-18:1)[lp] + H2O[lp] => H+[lp] + oleate[lp] + diglyceride (1-16:1, 2-18:1)[lp] YBR204C or YKR089C or YMR313C or YOR081C Glycerolipid metabolism +r_3288 TAG lipase (1-18:0, 2-18:1, 3-16:0), lipid particle triglyceride (1-18:0, 2-18:1, 3-16:0)[lp] + H2O[lp] => H+[lp] + palmitate[lp] + diglyceride (1-18:0, 2-18:1)[lp] YBR204C or YKR089C or YMR313C or YOR081C Glycerolipid metabolism +r_3289 TAG lipase (1-18:0, 2-18:1, 3-16:1), lipid particle triglyceride (1-18:0, 2-18:1, 3-16:1)[lp] + H2O[lp] => H+[lp] + palmitoleate[lp] + diglyceride (1-18:0, 2-18:1)[lp] YBR204C or YKR089C or YMR313C or YOR081C Glycerolipid metabolism +r_3290 TAG lipase (1-18:0, 2-18:1, 3-18:0), lipid particle triglyceride (1-18:0, 2-18:1, 3-18:0)[lp] + H2O[lp] => H+[lp] + stearate[lp] + diglyceride (1-18:0, 2-18:1)[lp] YBR204C or YKR089C or YMR313C or YOR081C Glycerolipid metabolism +r_3291 TAG lipase (1-18:0, 2-18:1, 3-18:1), lipid particle triglyceride (1-18:0, 2-18:1, 3-18:1)[lp] + H2O[lp] => H+[lp] + oleate[lp] + diglyceride (1-18:0, 2-18:1)[lp] YBR204C or YKR089C or YMR313C or YOR081C Glycerolipid metabolism +r_3292 TAG lipase (1-18:1, 2-18:1, 3-16:0), lipid particle triglyceride (1-18:1, 2-18:1, 3-16:0)[lp] + H2O[lp] => H+[lp] + palmitate[lp] + diglyceride (1-18:1, 2-18:1)[lp] YBR204C or YKR089C or YMR313C or YOR081C Glycerolipid metabolism +r_3293 TAG lipase (1-18:1, 2-18:1, 3-16:1), lipid particle triglyceride (1-18:1, 2-18:1, 3-16:1)[lp] + H2O[lp] => H+[lp] + palmitoleate[lp] + diglyceride (1-18:1, 2-18:1)[lp] YBR204C or YKR089C or YMR313C or YOR081C Glycerolipid metabolism +r_3294 TAG lipase (1-18:1, 2-18:1, 3-18:0), lipid particle triglyceride (1-18:1, 2-18:1, 3-18:0)[lp] + H2O[lp] => H+[lp] + stearate[lp] + diglyceride (1-18:1, 2-18:1)[lp] YBR204C or YKR089C or YMR313C or YOR081C Glycerolipid metabolism +r_3295 TAG lipase (1-18:1, 2-18:1, 3-18:1), lipid particle triglyceride (1-18:1, 2-18:1, 3-18:1)[lp] + H2O[lp] => H+[lp] + oleate[lp] + diglyceride (1-18:1, 2-18:1)[lp] YBR204C or YKR089C or YMR313C or YOR081C Glycerolipid metabolism +r_3296 DAG lipase (1-16:0, 2-16:1), lipid particle diglyceride (1-16:0, 2-16:1)[lp] + H2O[lp] => H+[lp] + palmitoleate[lp] + 1-monoglyceride (16:0)[lp] YMR313C Glycerolipid metabolism +r_3297 DAG lipase (1-16:1, 2-16:1), lipid particle diglyceride (1-16:1, 2-16:1)[lp] + H2O[lp] => H+[lp] + palmitoleate[lp] + 1-monoglyceride (16:1)[lp] YCR068W or YMR313C Glycerolipid metabolism +r_3298 DAG lipase (1-18:0, 2-16:1), lipid particle diglyceride (1-18:0, 2-16:1)[lp] + H2O[lp] => H+[lp] + palmitoleate[lp] + 1-monoglyceride (18:0)[lp] YMR313C Glycerolipid metabolism +r_3299 DAG lipase (1-18:1, 2-16:1), lipid particle diglyceride (1-18:1, 2-16:1)[lp] + H2O[lp] => H+[lp] + palmitoleate[lp] + 1-monoglyceride (18:1)[lp] YMR313C Glycerolipid metabolism +r_3300 DAG lipase (1-16:0, 2-18:1), lipid particle diglyceride (1-16:0, 2-18:1)[lp] + H2O[lp] => H+[lp] + oleate[lp] + 1-monoglyceride (16:0)[lp] YMR313C Glycerolipid metabolism +r_3301 DAG lipase (1-16:1, 2-18:1), lipid particle diglyceride (1-16:1, 2-18:1)[lp] + H2O[lp] => H+[lp] + oleate[lp] + 1-monoglyceride (16:1)[lp] YMR313C Glycerolipid metabolism +r_3302 DAG lipase (1-18:0, 2-18:1), lipid particle diglyceride (1-18:0, 2-18:1)[lp] + H2O[lp] => H+[lp] + oleate[lp] + 1-monoglyceride (18:0)[lp] YMR313C Glycerolipid metabolism +r_3303 DAG lipase (1-18:1, 2-18:1), lipid particle diglyceride (1-18:1, 2-18:1)[lp] + H2O[lp] => H+[lp] + oleate[lp] + 1-monoglyceride (18:1)[lp] YMR313C Glycerolipid metabolism +r_3304 DAG lipase (1-16:0, 2-18:1), mitochondrion H2O[m] + diglyceride (1-16:0, 2-18:1)[m] => H+[m] + 1-monoglyceride (16:0)[m] + oleate[m] YDR058C Glycerolipid metabolism +r_3305 DAG lipase (1-16:1, 2-18:1), mitochondrion H2O[m] + diglyceride (1-16:1, 2-18:1)[m] => H+[m] + oleate[m] + 1-monoglyceride (16:1)[m] YDR058C Glycerolipid metabolism +r_3306 DAG lipase (1-18:0, 2-18:1), mitochondrion H2O[m] + diglyceride (1-18:0, 2-18:1)[m] => H+[m] + oleate[m] + 1-monoglyceride (18:0)[m] YDR058C Glycerolipid metabolism +r_3307 DAG lipase (1-18:1, 2-18:1), mitochondrion H2O[m] + diglyceride (1-18:1, 2-18:1)[m] => H+[m] + oleate[m] + 1-monoglyceride (18:1)[m] YDR058C Glycerolipid metabolism +r_3308 MAG lipase (1-16:0), lipid particle H2O[lp] + 1-monoglyceride (16:0)[lp] => H+[lp] + palmitate[lp] + glycerol[lp] YKL094W Glycerolipid metabolism +r_3309 MAG lipase (1-16:1), lipid particle H2O[lp] + 1-monoglyceride (16:1)[lp] => H+[lp] + palmitoleate[lp] + glycerol[lp] YKL094W Glycerolipid metabolism +r_3310 MAG lipase (1-18:0), lipid particle H2O[lp] + 1-monoglyceride (18:0)[lp] => H+[lp] + stearate[lp] + glycerol[lp] YKL094W Glycerolipid metabolism +r_3311 MAG lipase (1-18:1), lipid particle H2O[lp] + 1-monoglyceride (18:1)[lp] => H+[lp] + oleate[lp] + glycerol[lp] YKL094W Glycerolipid metabolism +r_3312 lysoPE (1-16:0) oleoyl-CoA acyltransferase, lipid particle oleoyl-CoA[lp] + 1-acylglycerophosphoethanolamine (16:0)[lp] => coenzyme A[lp] + phosphatidylethanolamine (1-16:0, 2-18:1)[lp] YMR313C Glycerolipid metabolism +r_3313 lysoPE (1-16:1) oleoyl-CoA acyltransferase, lipid particle oleoyl-CoA[lp] + 1-acylglycerophosphoethanolamine (16:1)[lp] => coenzyme A[lp] + phosphatidylethanolamine (1-16:1, 2-18:1)[lp] YMR313C Glycerolipid metabolism +r_3314 lysoPE (1-18:0) oleoyl-CoA acyltransferase, lipid particle oleoyl-CoA[lp] + 1-acylglycerophosphoethanolamine (18:0)[lp] => coenzyme A[lp] + phosphatidylethanolamine (1-18:0, 2-18:1)[lp] YMR313C Glycerolipid metabolism +r_3315 lysoPE (1-18:1) oleoyl-CoA acyltransferase, lipid particle oleoyl-CoA[lp] + 1-acylglycerophosphoethanolamine (18:1)[lp] => coenzyme A[lp] + phosphatidylethanolamine (1-18:1, 2-18:1)[lp] YMR313C Glycerolipid metabolism +r_3316 PC phospholipase A2 (1-16:0, 2-16:1), lipid particle H2O[lp] + phosphatidylcholine (1-16:0, 2-16:1)[lp] => H+[lp] + palmitoleate[lp] + 1-acylglycerophosphocholine (16:0)[lp] YKR089C Glycerolipid metabolism +r_3317 PC phospholipase A2 (1-16:1, 2-16:1), lipid particle H2O[lp] + phosphatidylcholine (1-16:1, 2-16:1)[lp] => H+[lp] + palmitoleate[lp] + 1-acylglycerophosphocholine (16:1)[lp] YKR089C Glycerolipid metabolism +r_3318 PC phospholipase A2 (1-18:0, 2-16:1), lipid particle H2O[lp] + phosphatidylcholine (1-18:0, 2-16:1)[lp] => H+[lp] + palmitoleate[lp] + 1-acylglycerophosphocholine (18:0)[lp] YKR089C Glycerolipid metabolism +r_3319 PC phospholipase A2 (1-18:1, 2-16:1), lipid particle H2O[lp] + phosphatidylcholine (1-18:1, 2-16:1)[lp] => H+[lp] + palmitoleate[lp] + 1-acylglycerophosphocholine (18:1)[lp] YKR089C Glycerolipid metabolism +r_3320 PC phospholipase A2 (1-16:0, 2-18:1), lipid particle H2O[lp] + phosphatidylcholine (1-16:0, 2-18:1)[lp] => H+[lp] + oleate[lp] + 1-acylglycerophosphocholine (16:0)[lp] YKR089C Glycerolipid metabolism +r_3321 PC phospholipase A2 (1-16:1, 2-18:1), lipid particle H2O[lp] + phosphatidylcholine (1-16:1, 2-18:1)[lp] => H+[lp] + oleate[lp] + 1-acylglycerophosphocholine (16:1)[lp] YKR089C Glycerolipid metabolism +r_3322 PC phospholipase A2 (1-18:0, 2-18:1), lipid particle H2O[lp] + phosphatidylcholine (1-18:0, 2-18:1)[lp] => H+[lp] + oleate[lp] + 1-acylglycerophosphocholine (18:0)[lp] YKR089C Glycerolipid metabolism +r_3323 PC phospholipase A2 (1-18:1, 2-18:1), lipid particle H2O[lp] + phosphatidylcholine (1-18:1, 2-18:1)[lp] => H+[lp] + oleate[lp] + 1-acylglycerophosphocholine (18:1)[lp] YKR089C Glycerolipid metabolism +r_3324 PE phospholipase A2 (1-16:0, 2-16:1), lipid particle H2O[lp] + phosphatidylethanolamine (1-16:0, 2-16:1)[lp] => H+[lp] + palmitoleate[lp] + 1-acylglycerophosphoethanolamine (16:0)[lp] YKR089C Glycerolipid metabolism +r_3325 PE phospholipase A2 (1-16:1, 2-16:1), lipid particle H2O[lp] + phosphatidylethanolamine (1-16:1, 2-16:1)[lp] => H+[lp] + palmitoleate[lp] + 1-acylglycerophosphoethanolamine (16:1)[lp] YKR089C Glycerolipid metabolism +r_3326 PE phospholipase A2 (1-18:0, 2-16:1), lipid particle H2O[lp] + phosphatidylethanolamine (1-18:0, 2-16:1)[lp] => H+[lp] + palmitoleate[lp] + 1-acylglycerophosphoethanolamine (18:0)[lp] YKR089C Glycerolipid metabolism +r_3327 PE phospholipase A2 (1-18:1, 2-16:1), lipid particle H2O[lp] + phosphatidylethanolamine (1-18:1, 2-16:1)[lp] => H+[lp] + palmitoleate[lp] + 1-acylglycerophosphoethanolamine (18:1)[lp] YKR089C Glycerolipid metabolism +r_3328 PE phospholipase A2 (1-16:0, 2-18:1), lipid particle H2O[lp] + phosphatidylethanolamine (1-16:0, 2-18:1)[lp] => H+[lp] + oleate[lp] + 1-acylglycerophosphoethanolamine (16:0)[lp] YKR089C Glycerolipid metabolism +r_3329 PE phospholipase A2 (1-16:1, 2-18:1), lipid particle H2O[lp] + phosphatidylethanolamine (1-16:1, 2-18:1)[lp] => H+[lp] + oleate[lp] + 1-acylglycerophosphoethanolamine (16:1)[lp] YKR089C Glycerolipid metabolism +r_3330 PE phospholipase A2 (1-18:0, 2-18:1), lipid particle H2O[lp] + phosphatidylethanolamine (1-18:0, 2-18:1)[lp] => H+[lp] + oleate[lp] + 1-acylglycerophosphoethanolamine (18:0)[lp] YKR089C Glycerolipid metabolism +r_3331 PE phospholipase A2 (1-18:1, 2-18:1), lipid particle H2O[lp] + phosphatidylethanolamine (1-18:1, 2-18:1)[lp] => H+[lp] + oleate[lp] + 1-acylglycerophosphoethanolamine (18:1)[lp] YKR089C Glycerolipid metabolism +r_3332 PA kinase (1-16:0, 2-16:1), Golgi membrane phosphatidate (1-16:0, 2-16:1)[gm] + H+[gm] + ATP[gm] <=> ADP[gm] + 1,2-diacylglycerol 3-diphosphate (1-16:0, 2-16:1)[gm] Glycerolipid metabolism +r_3333 PA kinase (1-16:1, 2-16:1), Golgi membrane phosphatidate (1-16:1, 2-16:1)[gm] + H+[gm] + ATP[gm] <=> ADP[gm] + 1,2-diacylglycerol 3-diphosphate (1-16:1, 2-16:1)[gm] Glycerolipid metabolism +r_3334 PA kinase (1-18:0, 2-16:1), Golgi membrane phosphatidate (1-18:0, 2-16:1)[gm] + H+[gm] + ATP[gm] <=> ADP[gm] + 1,2-diacylglycerol 3-diphosphate (1-18:0, 2-16:1)[gm] Glycerolipid metabolism +r_3335 PA kinase (1-18:1, 2-16:1), Golgi membrane phosphatidate (1-18:1, 2-16:1)[gm] + H+[gm] + ATP[gm] <=> ADP[gm] + 1,2-diacylglycerol 3-diphosphate (1-18:1, 2-16:1)[gm] Glycerolipid metabolism +r_3336 PA kinase (1-16:0, 2-18:1), Golgi membrane phosphatidate (1-16:0, 2-18:1)[gm] + H+[gm] + ATP[gm] <=> ADP[gm] + 1,2-diacylglycerol 3-diphosphate (1-16:0, 2-18:1)[gm] Glycerolipid metabolism +r_3337 PA kinase (1-16:1, 2-18:1), Golgi membrane phosphatidate (1-16:1, 2-18:1)[gm] + H+[gm] + ATP[gm] <=> ADP[gm] + 1,2-diacylglycerol 3-diphosphate (1-16:1, 2-18:1)[gm] Glycerolipid metabolism +r_3338 PA kinase (1-18:0, 2-18:1), Golgi membrane phosphatidate (1-18:0, 2-18:1)[gm] + H+[gm] + ATP[gm] <=> ADP[gm] + 1,2-diacylglycerol 3-diphosphate (1-18:0, 2-18:1)[gm] Glycerolipid metabolism +r_3339 PA kinase (1-18:1, 2-18:1), Golgi membrane phosphatidate (1-18:1, 2-18:1)[gm] + H+[gm] + ATP[gm] <=> ADP[gm] + 1,2-diacylglycerol 3-diphosphate (1-18:1, 2-18:1)[gm] Glycerolipid metabolism +r_3340 PA kinase (1-16:0, 2-16:1), vacuolar membrane phosphatidate (1-16:0, 2-16:1)[vm] + H+[vm] + ATP[vm] <=> ADP[vm] + 1,2-diacylglycerol 3-diphosphate (1-16:0, 2-16:1)[vm] Glycerolipid metabolism +r_3341 PA kinase (1-16:1, 2-16:1), vacuolar membrane phosphatidate (1-16:1, 2-16:1)[vm] + H+[vm] + ATP[vm] <=> ADP[vm] + 1,2-diacylglycerol 3-diphosphate (1-16:1, 2-16:1)[vm] Glycerolipid metabolism +r_3342 PA kinase (1-18:0, 2-16:1), vacuolar membrane phosphatidate (1-18:0, 2-16:1)[vm] + H+[vm] + ATP[vm] <=> ADP[vm] + 1,2-diacylglycerol 3-diphosphate (1-18:0, 2-16:1)[vm] Glycerolipid metabolism +r_3343 PA kinase (1-18:1, 2-16:1), vacuolar membrane phosphatidate (1-18:1, 2-16:1)[vm] + H+[vm] + ATP[vm] <=> ADP[vm] + 1,2-diacylglycerol 3-diphosphate (1-18:1, 2-16:1)[vm] Glycerolipid metabolism +r_3344 PA kinase (1-16:0, 2-18:1), vacuolar membrane phosphatidate (1-16:0, 2-18:1)[vm] + H+[vm] + ATP[vm] <=> ADP[vm] + 1,2-diacylglycerol 3-diphosphate (1-16:0, 2-18:1)[vm] Glycerolipid metabolism +r_3345 PA kinase (1-16:1, 2-18:1), vacuolar membrane phosphatidate (1-16:1, 2-18:1)[vm] + H+[vm] + ATP[vm] <=> ADP[vm] + 1,2-diacylglycerol 3-diphosphate (1-16:1, 2-18:1)[vm] Glycerolipid metabolism +r_3346 PA kinase (1-18:0, 2-18:1), vacuolar membrane phosphatidate (1-18:0, 2-18:1)[vm] + H+[vm] + ATP[vm] <=> ADP[vm] + 1,2-diacylglycerol 3-diphosphate (1-18:0, 2-18:1)[vm] Glycerolipid metabolism +r_3347 PA kinase (1-18:1, 2-18:1), vacuolar membrane phosphatidate (1-18:1, 2-18:1)[vm] + H+[vm] + ATP[vm] <=> ADP[vm] + 1,2-diacylglycerol 3-diphosphate (1-18:1, 2-18:1)[vm] Glycerolipid metabolism +r_3348 inositolphosphotransferase (PI (1-16:0, 2-16:1) MIPC-A (C24)) mannosylinositol phosphorylceramide A (C24)[g] + 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-16:1)[gm] => inositol phosphomannosylinositol phosphoceramide A (C24)[g] + diglyceride (1-16:0, 2-16:1)[gm] YDR072C Sphingoglycolipid metabolism +r_3349 inositolphosphotransferase (PI (1-16:1, 2-16:1) MIPC-A (C24)) mannosylinositol phosphorylceramide A (C24)[g] + 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-16:1)[gm] => inositol phosphomannosylinositol phosphoceramide A (C24)[g] + diglyceride (1-16:1, 2-16:1)[gm] YDR072C Sphingoglycolipid metabolism +r_3350 inositolphosphotransferase (PI (1-18:0, 2-16:1) MIPC-A (C24)) mannosylinositol phosphorylceramide A (C24)[g] + 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-16:1)[gm] => inositol phosphomannosylinositol phosphoceramide A (C24)[g] + diglyceride (1-18:0, 2-16:1)[gm] YDR072C Sphingoglycolipid metabolism +r_3351 inositolphosphotransferase (PI (1-18:1, 2-16:1) MIPC-A (C24)) mannosylinositol phosphorylceramide A (C24)[g] + 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-16:1)[gm] => inositol phosphomannosylinositol phosphoceramide A (C24)[g] + diglyceride (1-18:1, 2-16:1)[gm] YDR072C Sphingoglycolipid metabolism +r_3352 inositolphosphotransferase (PI (1-16:0, 2-18:1) MIPC-A (C24)) mannosylinositol phosphorylceramide A (C24)[g] + 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-18:1)[gm] => inositol phosphomannosylinositol phosphoceramide A (C24)[g] + diglyceride (1-16:0, 2-18:1)[gm] YDR072C Sphingoglycolipid metabolism +r_3353 inositolphosphotransferase (PI (1-16:1, 2-18:1) MIPC-A (C24)) mannosylinositol phosphorylceramide A (C24)[g] + 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-18:1)[gm] => inositol phosphomannosylinositol phosphoceramide A (C24)[g] + diglyceride (1-16:1, 2-18:1)[gm] YDR072C Sphingoglycolipid metabolism +r_3354 inositolphosphotransferase (PI (1-18:0, 2-18:1) MIPC-A (C24)) mannosylinositol phosphorylceramide A (C24)[g] + 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-18:1)[gm] => inositol phosphomannosylinositol phosphoceramide A (C24)[g] + diglyceride (1-18:0, 2-18:1)[gm] YDR072C Sphingoglycolipid metabolism +r_3355 inositolphosphotransferase (PI (1-18:1, 2-18:1) MIPC-A (C24)) mannosylinositol phosphorylceramide A (C24)[g] + 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-18:1)[gm] => inositol phosphomannosylinositol phosphoceramide A (C24)[g] + diglyceride (1-18:1, 2-18:1)[gm] YDR072C Sphingoglycolipid metabolism +r_3356 inositolphosphotransferase (PI (1-16:0, 2-16:1) MIPC-A (C26)) mannosylinositol phosphorylceramide A (C26)[g] + 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-16:1)[gm] => inositol phosphomannosylinositol phosphoceramide A (C26)[g] + diglyceride (1-16:0, 2-16:1)[gm] YDR072C Sphingoglycolipid metabolism +r_3357 inositolphosphotransferase (PI (1-16:1, 2-16:1) MIPC-A (C26)) mannosylinositol phosphorylceramide A (C26)[g] + 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-16:1)[gm] => inositol phosphomannosylinositol phosphoceramide A (C26)[g] + diglyceride (1-16:1, 2-16:1)[gm] YDR072C Sphingoglycolipid metabolism +r_3358 inositolphosphotransferase (PI (1-18:0, 2-16:1) MIPC-A (C26)) mannosylinositol phosphorylceramide A (C26)[g] + 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-16:1)[gm] => inositol phosphomannosylinositol phosphoceramide A (C26)[g] + diglyceride (1-18:0, 2-16:1)[gm] YDR072C Sphingoglycolipid metabolism +r_3359 inositolphosphotransferase (PI (1-18:1, 2-16:1) MIPC-A (C26)) mannosylinositol phosphorylceramide A (C26)[g] + 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-16:1)[gm] => inositol phosphomannosylinositol phosphoceramide A (C26)[g] + diglyceride (1-18:1, 2-16:1)[gm] YDR072C Sphingoglycolipid metabolism +r_3360 inositolphosphotransferase (PI (1-16:0, 2-18:1) MIPC-A (C26)) mannosylinositol phosphorylceramide A (C26)[g] + 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-18:1)[gm] => inositol phosphomannosylinositol phosphoceramide A (C26)[g] + diglyceride (1-16:0, 2-18:1)[gm] YDR072C Sphingoglycolipid metabolism +r_3361 inositolphosphotransferase (PI (1-16:1, 2-18:1) MIPC-A (C26)) mannosylinositol phosphorylceramide A (C26)[g] + 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-18:1)[gm] => inositol phosphomannosylinositol phosphoceramide A (C26)[g] + diglyceride (1-16:1, 2-18:1)[gm] YDR072C Sphingoglycolipid metabolism +r_3362 inositolphosphotransferase (PI (1-18:0, 2-18:1) MIPC-A (C26)) mannosylinositol phosphorylceramide A (C26)[g] + 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-18:1)[gm] => inositol phosphomannosylinositol phosphoceramide A (C26)[g] + diglyceride (1-18:0, 2-18:1)[gm] YDR072C Sphingoglycolipid metabolism +r_3363 inositolphosphotransferase (PI (1-18:1, 2-18:1) MIPC-A (C26)) mannosylinositol phosphorylceramide A (C26)[g] + 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-18:1)[gm] => inositol phosphomannosylinositol phosphoceramide A (C26)[g] + diglyceride (1-18:1, 2-18:1)[gm] YDR072C Sphingoglycolipid metabolism +r_3364 inositolphosphotransferase (PI (1-16:0, 2-16:1) MIPC-B' (C24)) mannosylinositol phosphorylceramide B' (C24)[g] + 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-16:1)[gm] => inositol phosphomannosylinositol phosphoceramide B' (C24)[g] + diglyceride (1-16:0, 2-16:1)[gm] YDR072C Sphingoglycolipid metabolism +r_3365 inositolphosphotransferase (PI (1-16:1, 2-16:1) MIPC-B' (C24)) mannosylinositol phosphorylceramide B' (C24)[g] + 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-16:1)[gm] => inositol phosphomannosylinositol phosphoceramide B' (C24)[g] + diglyceride (1-16:1, 2-16:1)[gm] YDR072C Sphingoglycolipid metabolism +r_3366 inositolphosphotransferase (PI (1-18:0, 2-16:1) MIPC-B' (C24)) mannosylinositol phosphorylceramide B' (C24)[g] + 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-16:1)[gm] => inositol phosphomannosylinositol phosphoceramide B' (C24)[g] + diglyceride (1-18:0, 2-16:1)[gm] YDR072C Sphingoglycolipid metabolism +r_3367 inositolphosphotransferase (PI (1-18:1, 2-16:1) MIPC-B' (C24)) mannosylinositol phosphorylceramide B' (C24)[g] + 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-16:1)[gm] => inositol phosphomannosylinositol phosphoceramide B' (C24)[g] + diglyceride (1-18:1, 2-16:1)[gm] YDR072C Sphingoglycolipid metabolism +r_3368 inositolphosphotransferase (PI (1-16:0, 2-18:1) MIPC-B' (C24)) mannosylinositol phosphorylceramide B' (C24)[g] + 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-18:1)[gm] => inositol phosphomannosylinositol phosphoceramide B' (C24)[g] + diglyceride (1-16:0, 2-18:1)[gm] YDR072C Sphingoglycolipid metabolism +r_3369 inositolphosphotransferase (PI (1-16:1, 2-18:1) MIPC-B' (C24)) mannosylinositol phosphorylceramide B' (C24)[g] + 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-18:1)[gm] => inositol phosphomannosylinositol phosphoceramide B' (C24)[g] + diglyceride (1-16:1, 2-18:1)[gm] YDR072C Sphingoglycolipid metabolism +r_3370 inositolphosphotransferase (PI (1-18:0, 2-18:1) MIPC-B' (C24)) mannosylinositol phosphorylceramide B' (C24)[g] + 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-18:1)[gm] => inositol phosphomannosylinositol phosphoceramide B' (C24)[g] + diglyceride (1-18:0, 2-18:1)[gm] YDR072C Sphingoglycolipid metabolism +r_3371 inositolphosphotransferase (PI (1-18:1, 2-18:1) MIPC-B' (C24)) mannosylinositol phosphorylceramide B' (C24)[g] + 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-18:1)[gm] => inositol phosphomannosylinositol phosphoceramide B' (C24)[g] + diglyceride (1-18:1, 2-18:1)[gm] YDR072C Sphingoglycolipid metabolism +r_3372 inositolphosphotransferase (PI (1-16:0, 2-16:1) MIPC-B' (C26)) mannosylinositol phosphorylceramide B' (C26)[g] + 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-16:1)[gm] => inositol phosphomannosylinositol phosphoceramide B' (C26)[g] + diglyceride (1-16:0, 2-16:1)[gm] YDR072C Sphingoglycolipid metabolism +r_3373 inositolphosphotransferase (PI (1-16:1, 2-16:1) MIPC-B' (C26)) mannosylinositol phosphorylceramide B' (C26)[g] + 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-16:1)[gm] => inositol phosphomannosylinositol phosphoceramide B' (C26)[g] + diglyceride (1-16:1, 2-16:1)[gm] YDR072C Sphingoglycolipid metabolism +r_3374 inositolphosphotransferase (PI (1-18:0, 2-16:1) MIPC-B' (C26)) mannosylinositol phosphorylceramide B' (C26)[g] + 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-16:1)[gm] => inositol phosphomannosylinositol phosphoceramide B' (C26)[g] + diglyceride (1-18:0, 2-16:1)[gm] YDR072C Sphingoglycolipid metabolism +r_3375 inositolphosphotransferase (PI (1-18:1, 2-16:1) MIPC-B' (C26)) mannosylinositol phosphorylceramide B' (C26)[g] + 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-16:1)[gm] => inositol phosphomannosylinositol phosphoceramide B' (C26)[g] + diglyceride (1-18:1, 2-16:1)[gm] YDR072C Sphingoglycolipid metabolism +r_3376 inositolphosphotransferase (PI (1-16:0, 2-18:1) MIPC-B' (C26)) mannosylinositol phosphorylceramide B' (C26)[g] + 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-18:1)[gm] => inositol phosphomannosylinositol phosphoceramide B' (C26)[g] + diglyceride (1-16:0, 2-18:1)[gm] YDR072C Sphingoglycolipid metabolism +r_3377 inositolphosphotransferase (PI (1-16:1, 2-18:1) MIPC-B' (C26)) mannosylinositol phosphorylceramide B' (C26)[g] + 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-18:1)[gm] => inositol phosphomannosylinositol phosphoceramide B' (C26)[g] + diglyceride (1-16:1, 2-18:1)[gm] YDR072C Sphingoglycolipid metabolism +r_3378 inositolphosphotransferase (PI (1-18:0, 2-18:1) MIPC-B' (C26)) mannosylinositol phosphorylceramide B' (C26)[g] + 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-18:1)[gm] => inositol phosphomannosylinositol phosphoceramide B' (C26)[g] + diglyceride (1-18:0, 2-18:1)[gm] YDR072C Sphingoglycolipid metabolism +r_3379 inositolphosphotransferase (PI (1-18:1, 2-18:1) MIPC-B' (C26)) mannosylinositol phosphorylceramide B' (C26)[g] + 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-18:1)[gm] => inositol phosphomannosylinositol phosphoceramide B' (C26)[g] + diglyceride (1-18:1, 2-18:1)[gm] YDR072C Sphingoglycolipid metabolism +r_3380 inositolphosphotransferase (PI (1-16:0, 2-16:1) MIPC-B (C24)) mannosylinositol phosphorylceramide B (C24)[g] + 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-16:1)[gm] => inositol phosphomannosylinositol phosphoceramide B (C24)[g] + diglyceride (1-16:0, 2-16:1)[gm] YDR072C Sphingoglycolipid metabolism +r_3381 inositolphosphotransferase (PI (1-16:1, 2-16:1) MIPC-B (C24)) mannosylinositol phosphorylceramide B (C24)[g] + 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-16:1)[gm] => inositol phosphomannosylinositol phosphoceramide B (C24)[g] + diglyceride (1-16:1, 2-16:1)[gm] YDR072C Sphingoglycolipid metabolism +r_3382 inositolphosphotransferase (PI (1-18:0, 2-16:1) MIPC-B (C24)) mannosylinositol phosphorylceramide B (C24)[g] + 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-16:1)[gm] => inositol phosphomannosylinositol phosphoceramide B (C24)[g] + diglyceride (1-18:0, 2-16:1)[gm] YDR072C Sphingoglycolipid metabolism +r_3383 inositolphosphotransferase (PI (1-18:1, 2-16:1) MIPC-B (C24)) mannosylinositol phosphorylceramide B (C24)[g] + 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-16:1)[gm] => inositol phosphomannosylinositol phosphoceramide B (C24)[g] + diglyceride (1-18:1, 2-16:1)[gm] YDR072C Sphingoglycolipid metabolism +r_3384 inositolphosphotransferase (PI (1-16:0, 2-18:1) MIPC-B (C24)) mannosylinositol phosphorylceramide B (C24)[g] + 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-18:1)[gm] => inositol phosphomannosylinositol phosphoceramide B (C24)[g] + diglyceride (1-16:0, 2-18:1)[gm] YDR072C Sphingoglycolipid metabolism +r_3385 inositolphosphotransferase (PI (1-16:1, 2-18:1) MIPC-B (C24)) mannosylinositol phosphorylceramide B (C24)[g] + 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-18:1)[gm] => inositol phosphomannosylinositol phosphoceramide B (C24)[g] + diglyceride (1-16:1, 2-18:1)[gm] YDR072C Sphingoglycolipid metabolism +r_3386 inositolphosphotransferase (PI (1-18:0, 2-18:1) MIPC-B (C24)) mannosylinositol phosphorylceramide B (C24)[g] + 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-18:1)[gm] => inositol phosphomannosylinositol phosphoceramide B (C24)[g] + diglyceride (1-18:0, 2-18:1)[gm] YDR072C Sphingoglycolipid metabolism +r_3387 inositolphosphotransferase (PI (1-18:1, 2-18:1) MIPC-B (C24)) mannosylinositol phosphorylceramide B (C24)[g] + 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-18:1)[gm] => inositol phosphomannosylinositol phosphoceramide B (C24)[g] + diglyceride (1-18:1, 2-18:1)[gm] YDR072C Sphingoglycolipid metabolism +r_3388 inositolphosphotransferase (PI (1-16:0, 2-16:1) MIPC-B (C26)) mannosylinositol phosphorylceramide B (C26)[g] + 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-16:1)[gm] => inositol phosphomannosylinositol phosphoceramide B (C26)[g] + diglyceride (1-16:0, 2-16:1)[gm] YDR072C Sphingoglycolipid metabolism +r_3389 inositolphosphotransferase (PI (1-16:1, 2-16:1) MIPC-B (C26)) mannosylinositol phosphorylceramide B (C26)[g] + 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-16:1)[gm] => inositol phosphomannosylinositol phosphoceramide B (C26)[g] + diglyceride (1-16:1, 2-16:1)[gm] YDR072C Sphingoglycolipid metabolism +r_3390 inositolphosphotransferase (PI (1-18:0, 2-16:1) MIPC-B (C26)) mannosylinositol phosphorylceramide B (C26)[g] + 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-16:1)[gm] => inositol phosphomannosylinositol phosphoceramide B (C26)[g] + diglyceride (1-18:0, 2-16:1)[gm] YDR072C Sphingoglycolipid metabolism +r_3391 inositolphosphotransferase (PI (1-18:1, 2-16:1) MIPC-B (C26)) mannosylinositol phosphorylceramide B (C26)[g] + 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-16:1)[gm] => inositol phosphomannosylinositol phosphoceramide B (C26)[g] + diglyceride (1-18:1, 2-16:1)[gm] YDR072C Sphingoglycolipid metabolism +r_3392 inositolphosphotransferase (PI (1-16:0, 2-18:1) MIPC-B (C26)) mannosylinositol phosphorylceramide B (C26)[g] + 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-18:1)[gm] => inositol phosphomannosylinositol phosphoceramide B (C26)[g] + diglyceride (1-16:0, 2-18:1)[gm] YDR072C Sphingoglycolipid metabolism +r_3393 inositolphosphotransferase (PI (1-16:1, 2-18:1) MIPC-B (C26)) mannosylinositol phosphorylceramide B (C26)[g] + 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-18:1)[gm] => inositol phosphomannosylinositol phosphoceramide B (C26)[g] + diglyceride (1-16:1, 2-18:1)[gm] YDR072C Sphingoglycolipid metabolism +r_3394 inositolphosphotransferase (PI (1-18:0, 2-18:1) MIPC-B (C26)) mannosylinositol phosphorylceramide B (C26)[g] + 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-18:1)[gm] => inositol phosphomannosylinositol phosphoceramide B (C26)[g] + diglyceride (1-18:0, 2-18:1)[gm] YDR072C Sphingoglycolipid metabolism +r_3395 inositolphosphotransferase (PI (1-18:1, 2-18:1) MIPC-B (C26)) mannosylinositol phosphorylceramide B (C26)[g] + 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-18:1)[gm] => inositol phosphomannosylinositol phosphoceramide B (C26)[g] + diglyceride (1-18:1, 2-18:1)[gm] YDR072C Sphingoglycolipid metabolism +r_3396 inositolphosphotransferase (PI (1-16:0, 2-16:1) MIPC-C (C24)) mannosylinositol phosphorylceramide C (C24)[g] + 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-16:1)[gm] => inositol phosphomannosylinositol phosphoceramide C (C24)[g] + diglyceride (1-16:0, 2-16:1)[gm] YDR072C Sphingoglycolipid metabolism +r_3397 inositolphosphotransferase (PI (1-16:1, 2-16:1) MIPC-C (C24)) mannosylinositol phosphorylceramide C (C24)[g] + 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-16:1)[gm] => inositol phosphomannosylinositol phosphoceramide C (C24)[g] + diglyceride (1-16:1, 2-16:1)[gm] YDR072C Sphingoglycolipid metabolism +r_3398 inositolphosphotransferase (PI (1-18:0, 2-16:1) MIPC-C (C24)) mannosylinositol phosphorylceramide C (C24)[g] + 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-16:1)[gm] => inositol phosphomannosylinositol phosphoceramide C (C24)[g] + diglyceride (1-18:0, 2-16:1)[gm] YDR072C Sphingoglycolipid metabolism +r_3399 inositolphosphotransferase (PI (1-18:1, 2-16:1) MIPC-C (C24)) mannosylinositol phosphorylceramide C (C24)[g] + 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-16:1)[gm] => inositol phosphomannosylinositol phosphoceramide C (C24)[g] + diglyceride (1-18:1, 2-16:1)[gm] YDR072C Sphingoglycolipid metabolism +r_3400 inositolphosphotransferase (PI (1-16:0, 2-18:1) MIPC-C (C24)) mannosylinositol phosphorylceramide C (C24)[g] + 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-18:1)[gm] => inositol phosphomannosylinositol phosphoceramide C (C24)[g] + diglyceride (1-16:0, 2-18:1)[gm] YDR072C Sphingoglycolipid metabolism +r_3401 inositolphosphotransferase (PI (1-16:1, 2-18:1) MIPC-C (C24)) mannosylinositol phosphorylceramide C (C24)[g] + 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-18:1)[gm] => inositol phosphomannosylinositol phosphoceramide C (C24)[g] + diglyceride (1-16:1, 2-18:1)[gm] YDR072C Sphingoglycolipid metabolism +r_3402 inositolphosphotransferase (PI (1-18:0, 2-18:1) MIPC-C (C24)) mannosylinositol phosphorylceramide C (C24)[g] + 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-18:1)[gm] => inositol phosphomannosylinositol phosphoceramide C (C24)[g] + diglyceride (1-18:0, 2-18:1)[gm] YDR072C Sphingoglycolipid metabolism +r_3403 inositolphosphotransferase (PI (1-18:1, 2-18:1) MIPC-C (C24)) mannosylinositol phosphorylceramide C (C24)[g] + 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-18:1)[gm] => inositol phosphomannosylinositol phosphoceramide C (C24)[g] + diglyceride (1-18:1, 2-18:1)[gm] YDR072C Sphingoglycolipid metabolism +r_3404 inositolphosphotransferase (PI (1-16:0, 2-16:1) MIPC-C (C26)) mannosylinositol phosphorylceramide C (C26)[g] + 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-16:1)[gm] => inositol phosphomannosylinositol phosphoceramide C (C26)[g] + diglyceride (1-16:0, 2-16:1)[gm] YDR072C Sphingoglycolipid metabolism +r_3405 inositolphosphotransferase (PI (1-16:1, 2-16:1) MIPC-C (C26)) mannosylinositol phosphorylceramide C (C26)[g] + 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-16:1)[gm] => inositol phosphomannosylinositol phosphoceramide C (C26)[g] + diglyceride (1-16:1, 2-16:1)[gm] YDR072C Sphingoglycolipid metabolism +r_3406 inositolphosphotransferase (PI (1-18:0, 2-16:1) MIPC-C (C26)) mannosylinositol phosphorylceramide C (C26)[g] + 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-16:1)[gm] => inositol phosphomannosylinositol phosphoceramide C (C26)[g] + diglyceride (1-18:0, 2-16:1)[gm] YDR072C Sphingoglycolipid metabolism +r_3407 inositolphosphotransferase (PI (1-18:1, 2-16:1) MIPC-C (C26)) mannosylinositol phosphorylceramide C (C26)[g] + 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-16:1)[gm] => inositol phosphomannosylinositol phosphoceramide C (C26)[g] + diglyceride (1-18:1, 2-16:1)[gm] YDR072C Sphingoglycolipid metabolism +r_3408 inositolphosphotransferase (PI (1-16:0, 2-18:1) MIPC-C (C26)) mannosylinositol phosphorylceramide C (C26)[g] + 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-18:1)[gm] => inositol phosphomannosylinositol phosphoceramide C (C26)[g] + diglyceride (1-16:0, 2-18:1)[gm] YDR072C Sphingoglycolipid metabolism +r_3409 inositolphosphotransferase (PI (1-16:1, 2-18:1) MIPC-C (C26)) mannosylinositol phosphorylceramide C (C26)[g] + 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-18:1)[gm] => inositol phosphomannosylinositol phosphoceramide C (C26)[g] + diglyceride (1-16:1, 2-18:1)[gm] YDR072C Sphingoglycolipid metabolism +r_3410 inositolphosphotransferase (PI (1-18:0, 2-18:1) MIPC-C (C26)) mannosylinositol phosphorylceramide C (C26)[g] + 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-18:1)[gm] => inositol phosphomannosylinositol phosphoceramide C (C26)[g] + diglyceride (1-18:0, 2-18:1)[gm] YDR072C Sphingoglycolipid metabolism +r_3411 inositolphosphotransferase (PI (1-18:1, 2-18:1) MIPC-C (C26)) mannosylinositol phosphorylceramide C (C26)[g] + 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-18:1)[gm] => inositol phosphomannosylinositol phosphoceramide C (C26)[g] + diglyceride (1-18:1, 2-18:1)[gm] YDR072C Sphingoglycolipid metabolism +r_3412 inositolphosphotransferase (PI (1-16:0, 2-16:1) MIPC-D (C24)) mannosylinositol phosphorylceramide D (C24)[g] + 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-16:1)[gm] => inositol phosphomannosylinositol phosphoceramide D (C24)[g] + diglyceride (1-16:0, 2-16:1)[gm] YDR072C Sphingoglycolipid metabolism +r_3413 inositolphosphotransferase (PI (1-16:1, 2-16:1) MIPC-D (C24)) mannosylinositol phosphorylceramide D (C24)[g] + 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-16:1)[gm] => inositol phosphomannosylinositol phosphoceramide D (C24)[g] + diglyceride (1-16:1, 2-16:1)[gm] YDR072C Sphingoglycolipid metabolism +r_3414 inositolphosphotransferase (PI (1-18:0, 2-16:1) MIPC-D (C24)) mannosylinositol phosphorylceramide D (C24)[g] + 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-16:1)[gm] => inositol phosphomannosylinositol phosphoceramide D (C24)[g] + diglyceride (1-18:0, 2-16:1)[gm] YDR072C Sphingoglycolipid metabolism +r_3415 inositolphosphotransferase (PI (1-18:1, 2-16:1) MIPC-D (C24)) mannosylinositol phosphorylceramide D (C24)[g] + 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-16:1)[gm] => inositol phosphomannosylinositol phosphoceramide D (C24)[g] + diglyceride (1-18:1, 2-16:1)[gm] YDR072C Sphingoglycolipid metabolism +r_3416 inositolphosphotransferase (PI (1-16:0, 2-18:1) MIPC-D (C24)) mannosylinositol phosphorylceramide D (C24)[g] + 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-18:1)[gm] => inositol phosphomannosylinositol phosphoceramide D (C24)[g] + diglyceride (1-16:0, 2-18:1)[gm] YDR072C Sphingoglycolipid metabolism +r_3417 inositolphosphotransferase (PI (1-16:1, 2-18:1) MIPC-D (C24)) mannosylinositol phosphorylceramide D (C24)[g] + 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-18:1)[gm] => inositol phosphomannosylinositol phosphoceramide D (C24)[g] + diglyceride (1-16:1, 2-18:1)[gm] YDR072C Sphingoglycolipid metabolism +r_3418 inositolphosphotransferase (PI (1-18:0, 2-18:1) MIPC-D (C24)) mannosylinositol phosphorylceramide D (C24)[g] + 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-18:1)[gm] => inositol phosphomannosylinositol phosphoceramide D (C24)[g] + diglyceride (1-18:0, 2-18:1)[gm] YDR072C Sphingoglycolipid metabolism +r_3419 inositolphosphotransferase (PI (1-18:1, 2-18:1) MIPC-D (C24)) mannosylinositol phosphorylceramide D (C24)[g] + 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-18:1)[gm] => inositol phosphomannosylinositol phosphoceramide D (C24)[g] + diglyceride (1-18:1, 2-18:1)[gm] YDR072C Sphingoglycolipid metabolism +r_3420 inositolphosphotransferase (PI (1-16:0, 2-16:1) MIPC-D (C26)) mannosylinositol phosphorylceramide D (C26)[g] + 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-16:1)[gm] => inositol phosphomannosylinositol phosphoceramide D (C26)[g] + diglyceride (1-16:0, 2-16:1)[gm] YDR072C Sphingoglycolipid metabolism +r_3421 inositolphosphotransferase (PI (1-16:1, 2-16:1) MIPC-D (C26)) mannosylinositol phosphorylceramide D (C26)[g] + 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-16:1)[gm] => inositol phosphomannosylinositol phosphoceramide D (C26)[g] + diglyceride (1-16:1, 2-16:1)[gm] YDR072C Sphingoglycolipid metabolism +r_3422 inositolphosphotransferase (PI (1-18:0, 2-16:1) MIPC-D (C26)) mannosylinositol phosphorylceramide D (C26)[g] + 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-16:1)[gm] => inositol phosphomannosylinositol phosphoceramide D (C26)[g] + diglyceride (1-18:0, 2-16:1)[gm] YDR072C Sphingoglycolipid metabolism +r_3423 inositolphosphotransferase (PI (1-18:1, 2-16:1) MIPC-D (C26)) mannosylinositol phosphorylceramide D (C26)[g] + 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-16:1)[gm] => inositol phosphomannosylinositol phosphoceramide D (C26)[g] + diglyceride (1-18:1, 2-16:1)[gm] YDR072C Sphingoglycolipid metabolism +r_3424 inositolphosphotransferase (PI (1-16:0, 2-18:1) MIPC-D (C26)) mannosylinositol phosphorylceramide D (C26)[g] + 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-18:1)[gm] => inositol phosphomannosylinositol phosphoceramide D (C26)[g] + diglyceride (1-16:0, 2-18:1)[gm] YDR072C Sphingoglycolipid metabolism +r_3425 inositolphosphotransferase (PI (1-16:1, 2-18:1) MIPC-D (C26)) mannosylinositol phosphorylceramide D (C26)[g] + 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-18:1)[gm] => inositol phosphomannosylinositol phosphoceramide D (C26)[g] + diglyceride (1-16:1, 2-18:1)[gm] YDR072C Sphingoglycolipid metabolism +r_3426 inositolphosphotransferase (PI (1-18:0, 2-18:1) MIPC-D (C26)) mannosylinositol phosphorylceramide D (C26)[g] + 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-18:1)[gm] => inositol phosphomannosylinositol phosphoceramide D (C26)[g] + diglyceride (1-18:0, 2-18:1)[gm] YDR072C Sphingoglycolipid metabolism +r_3427 inositolphosphotransferase (PI (1-18:1, 2-18:1) MIPC-D (C26)) mannosylinositol phosphorylceramide D (C26)[g] + 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-18:1)[gm] => inositol phosphomannosylinositol phosphoceramide D (C26)[g] + diglyceride (1-18:1, 2-18:1)[gm] YDR072C Sphingoglycolipid metabolism +r_3428 IPC synthase (PI (1-16:0, 2-16:1) ceramide-1 (C24)) ceramide-1 (C24)[g] + 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-16:1)[gm] => inositol-P-ceramide A (C24)[g] + diglyceride (1-16:0, 2-16:1)[gm] YDR367W and YKL004W Sphingoglycolipid metabolism +r_3429 IPC synthase (PI (1-16:1, 2-16:1) ceramide-1 (C24)) ceramide-1 (C24)[g] + 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-16:1)[gm] => inositol-P-ceramide A (C24)[g] + diglyceride (1-16:1, 2-16:1)[gm] YDR367W and YKL004W Sphingoglycolipid metabolism +r_3430 IPC synthase (PI (1-18:0, 2-16:1) ceramide-1 (C24)) ceramide-1 (C24)[g] + 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-16:1)[gm] => inositol-P-ceramide A (C24)[g] + diglyceride (1-18:0, 2-16:1)[gm] YDR367W and YKL004W Sphingoglycolipid metabolism +r_3431 IPC synthase (PI (1-18:1, 2-16:1) ceramide-1 (C24)) ceramide-1 (C24)[g] + 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-16:1)[gm] => inositol-P-ceramide A (C24)[g] + diglyceride (1-18:1, 2-16:1)[gm] YDR367W and YKL004W Sphingoglycolipid metabolism +r_3432 IPC synthase (PI (1-16:0, 2-18:1) ceramide-1 (C24)) ceramide-1 (C24)[g] + 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-18:1)[gm] => inositol-P-ceramide A (C24)[g] + diglyceride (1-16:0, 2-18:1)[gm] YDR367W and YKL004W Sphingoglycolipid metabolism +r_3433 IPC synthase (PI (1-16:1, 2-18:1) ceramide-1 (C24)) ceramide-1 (C24)[g] + 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-18:1)[gm] => inositol-P-ceramide A (C24)[g] + diglyceride (1-16:1, 2-18:1)[gm] YDR367W and YKL004W Sphingoglycolipid metabolism +r_3434 IPC synthase (PI (1-18:0, 2-18:1) ceramide-1 (C24)) ceramide-1 (C24)[g] + 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-18:1)[gm] => inositol-P-ceramide A (C24)[g] + diglyceride (1-18:0, 2-18:1)[gm] YDR367W and YKL004W Sphingoglycolipid metabolism +r_3435 IPC synthase (PI (1-18:1, 2-18:1) ceramide-1 (C24)) ceramide-1 (C24)[g] + 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-18:1)[gm] => inositol-P-ceramide A (C24)[g] + diglyceride (1-18:1, 2-18:1)[gm] YDR367W and YKL004W Sphingoglycolipid metabolism +r_3436 IPC synthase (PI (1-16:0, 2-16:1) ceramide-1 (C26)) ceramide-1 (C26)[g] + 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-16:1)[gm] => inositol-P-ceramide A (C26)[g] + diglyceride (1-16:0, 2-16:1)[gm] YDR367W and YKL004W Sphingoglycolipid metabolism +r_3437 IPC synthase (PI (1-16:1, 2-16:1) ceramide-1 (C26)) ceramide-1 (C26)[g] + 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-16:1)[gm] => inositol-P-ceramide A (C26)[g] + diglyceride (1-16:1, 2-16:1)[gm] YDR367W and YKL004W Sphingoglycolipid metabolism +r_3438 IPC synthase (PI (1-18:0, 2-16:1) ceramide-1 (C26)) ceramide-1 (C26)[g] + 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-16:1)[gm] => inositol-P-ceramide A (C26)[g] + diglyceride (1-18:0, 2-16:1)[gm] YDR367W and YKL004W Sphingoglycolipid metabolism +r_3439 IPC synthase (PI (1-18:1, 2-16:1) ceramide-1 (C26)) ceramide-1 (C26)[g] + 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-16:1)[gm] => inositol-P-ceramide A (C26)[g] + diglyceride (1-18:1, 2-16:1)[gm] YDR367W and YKL004W Sphingoglycolipid metabolism +r_3440 IPC synthase (PI (1-16:0, 2-18:1) ceramide-1 (C26)) ceramide-1 (C26)[g] + 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-18:1)[gm] => inositol-P-ceramide A (C26)[g] + diglyceride (1-16:0, 2-18:1)[gm] YDR367W and YKL004W Sphingoglycolipid metabolism +r_3441 IPC synthase (PI (1-16:1, 2-18:1) ceramide-1 (C26)) ceramide-1 (C26)[g] + 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-18:1)[gm] => inositol-P-ceramide A (C26)[g] + diglyceride (1-16:1, 2-18:1)[gm] YDR367W and YKL004W Sphingoglycolipid metabolism +r_3442 IPC synthase (PI (1-18:0, 2-18:1) ceramide-1 (C26)) ceramide-1 (C26)[g] + 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-18:1)[gm] => inositol-P-ceramide A (C26)[g] + diglyceride (1-18:0, 2-18:1)[gm] YDR367W and YKL004W Sphingoglycolipid metabolism +r_3443 IPC synthase (PI (1-18:1, 2-18:1) ceramide-1 (C26)) ceramide-1 (C26)[g] + 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-18:1)[gm] => inositol-P-ceramide A (C26)[g] + diglyceride (1-18:1, 2-18:1)[gm] YDR367W and YKL004W Sphingoglycolipid metabolism +r_3444 IPC synthase (PI (1-16:0, 2-16:1) ceramide-2' (C24)) ceramide-2' (C24)[g] + 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-16:1)[gm] => inositol-P-ceramide B' (C24)[g] + diglyceride (1-16:0, 2-16:1)[gm] YDR367W and YKL004W Sphingoglycolipid metabolism +r_3445 IPC synthase (PI (1-16:1, 2-16:1) ceramide-2' (C24)) ceramide-2' (C24)[g] + 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-16:1)[gm] => inositol-P-ceramide B' (C24)[g] + diglyceride (1-16:1, 2-16:1)[gm] YDR367W and YKL004W Sphingoglycolipid metabolism +r_3446 IPC synthase (PI (1-18:0, 2-16:1) ceramide-2' (C24)) ceramide-2' (C24)[g] + 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-16:1)[gm] => inositol-P-ceramide B' (C24)[g] + diglyceride (1-18:0, 2-16:1)[gm] YDR367W and YKL004W Sphingoglycolipid metabolism +r_3447 IPC synthase (PI (1-18:1, 2-16:1) ceramide-2' (C24)) ceramide-2' (C24)[g] + 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-16:1)[gm] => inositol-P-ceramide B' (C24)[g] + diglyceride (1-18:1, 2-16:1)[gm] YDR367W and YKL004W Sphingoglycolipid metabolism +r_3448 IPC synthase (PI (1-16:0, 2-18:1) ceramide-2' (C24)) ceramide-2' (C24)[g] + 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-18:1)[gm] => inositol-P-ceramide B' (C24)[g] + diglyceride (1-16:0, 2-18:1)[gm] YDR367W and YKL004W Sphingoglycolipid metabolism +r_3449 IPC synthase (PI (1-16:1, 2-18:1) ceramide-2' (C24)) ceramide-2' (C24)[g] + 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-18:1)[gm] => inositol-P-ceramide B' (C24)[g] + diglyceride (1-16:1, 2-18:1)[gm] YDR367W and YKL004W Sphingoglycolipid metabolism +r_3450 IPC synthase (PI (1-18:0, 2-18:1) ceramide-2' (C24)) ceramide-2' (C24)[g] + 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-18:1)[gm] => inositol-P-ceramide B' (C24)[g] + diglyceride (1-18:0, 2-18:1)[gm] YDR367W and YKL004W Sphingoglycolipid metabolism +r_3451 IPC synthase (PI (1-18:1, 2-18:1) ceramide-2' (C24)) ceramide-2' (C24)[g] + 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-18:1)[gm] => inositol-P-ceramide B' (C24)[g] + diglyceride (1-18:1, 2-18:1)[gm] YDR367W and YKL004W Sphingoglycolipid metabolism +r_3452 IPC synthase (PI (1-16:0, 2-16:1) ceramide-2' (C26)) ceramide-2' (C26)[g] + 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-16:1)[gm] => inositol-P-ceramide B' (C26)[g] + diglyceride (1-16:0, 2-16:1)[gm] YDR367W and YKL004W Sphingoglycolipid metabolism +r_3453 IPC synthase (PI (1-16:1, 2-16:1) ceramide-2' (C26)) ceramide-2' (C26)[g] + 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-16:1)[gm] => inositol-P-ceramide B' (C26)[g] + diglyceride (1-16:1, 2-16:1)[gm] YDR367W and YKL004W Sphingoglycolipid metabolism +r_3454 IPC synthase (PI (1-18:0, 2-16:1) ceramide-2' (C26)) ceramide-2' (C26)[g] + 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-16:1)[gm] => inositol-P-ceramide B' (C26)[g] + diglyceride (1-18:0, 2-16:1)[gm] YDR367W and YKL004W Sphingoglycolipid metabolism +r_3455 IPC synthase (PI (1-18:1, 2-16:1) ceramide-2' (C26)) ceramide-2' (C26)[g] + 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-16:1)[gm] => inositol-P-ceramide B' (C26)[g] + diglyceride (1-18:1, 2-16:1)[gm] YDR367W and YKL004W Sphingoglycolipid metabolism +r_3456 IPC synthase (PI (1-16:0, 2-18:1) ceramide-2' (C26)) ceramide-2' (C26)[g] + 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-18:1)[gm] => inositol-P-ceramide B' (C26)[g] + diglyceride (1-16:0, 2-18:1)[gm] YDR367W and YKL004W Sphingoglycolipid metabolism +r_3457 IPC synthase (PI (1-16:1, 2-18:1) ceramide-2' (C26)) ceramide-2' (C26)[g] + 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-18:1)[gm] => inositol-P-ceramide B' (C26)[g] + diglyceride (1-16:1, 2-18:1)[gm] YDR367W and YKL004W Sphingoglycolipid metabolism +r_3458 IPC synthase (PI (1-18:0, 2-18:1) ceramide-2' (C26)) ceramide-2' (C26)[g] + 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-18:1)[gm] => inositol-P-ceramide B' (C26)[g] + diglyceride (1-18:0, 2-18:1)[gm] YDR367W and YKL004W Sphingoglycolipid metabolism +r_3459 IPC synthase (PI (1-18:1, 2-18:1) ceramide-2' (C26)) ceramide-2' (C26)[g] + 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-18:1)[gm] => inositol-P-ceramide B' (C26)[g] + diglyceride (1-18:1, 2-18:1)[gm] YDR367W and YKL004W Sphingoglycolipid metabolism +r_3460 IPC synthase (PI (1-16:0, 2-16:1) ceramide-2 (C24)) ceramide-2 (C24)[g] + 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-16:1)[gm] => inositol-P-ceramide B (C24)[g] + diglyceride (1-16:0, 2-16:1)[gm] YDR367W and YKL004W Sphingoglycolipid metabolism +r_3461 IPC synthase (PI (1-16:1, 2-16:1) ceramide-2 (C24)) ceramide-2 (C24)[g] + 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-16:1)[gm] => inositol-P-ceramide B (C24)[g] + diglyceride (1-16:1, 2-16:1)[gm] YDR367W and YKL004W Sphingoglycolipid metabolism +r_3462 IPC synthase (PI (1-18:0, 2-16:1) ceramide-2 (C24)) ceramide-2 (C24)[g] + 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-16:1)[gm] => inositol-P-ceramide B (C24)[g] + diglyceride (1-18:0, 2-16:1)[gm] YDR367W and YKL004W Sphingoglycolipid metabolism +r_3463 IPC synthase (PI (1-18:1, 2-16:1) ceramide-2 (C24)) ceramide-2 (C24)[g] + 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-16:1)[gm] => inositol-P-ceramide B (C24)[g] + diglyceride (1-18:1, 2-16:1)[gm] YDR367W and YKL004W Sphingoglycolipid metabolism +r_3464 IPC synthase (PI (1-16:0, 2-18:1) ceramide-2 (C24)) ceramide-2 (C24)[g] + 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-18:1)[gm] => inositol-P-ceramide B (C24)[g] + diglyceride (1-16:0, 2-18:1)[gm] YDR367W and YKL004W Sphingoglycolipid metabolism +r_3465 IPC synthase (PI (1-16:1, 2-18:1) ceramide-2 (C24)) ceramide-2 (C24)[g] + 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-18:1)[gm] => inositol-P-ceramide B (C24)[g] + diglyceride (1-16:1, 2-18:1)[gm] YDR367W and YKL004W Sphingoglycolipid metabolism +r_3466 IPC synthase (PI (1-18:0, 2-18:1) ceramide-2 (C24)) ceramide-2 (C24)[g] + 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-18:1)[gm] => inositol-P-ceramide B (C24)[g] + diglyceride (1-18:0, 2-18:1)[gm] YDR367W and YKL004W Sphingoglycolipid metabolism +r_3467 IPC synthase (PI (1-18:1, 2-18:1) ceramide-2 (C24)) ceramide-2 (C24)[g] + 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-18:1)[gm] => inositol-P-ceramide B (C24)[g] + diglyceride (1-18:1, 2-18:1)[gm] YDR367W and YKL004W Sphingoglycolipid metabolism +r_3468 IPC synthase (PI (1-16:0, 2-16:1) ceramide-2 (C26)) ceramide-2 (C26)[g] + 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-16:1)[gm] => inositol-P-ceramide B (C26)[g] + diglyceride (1-16:0, 2-16:1)[gm] YDR367W and YKL004W Sphingoglycolipid metabolism +r_3469 IPC synthase (PI (1-16:1, 2-16:1) ceramide-2 (C26)) ceramide-2 (C26)[g] + 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-16:1)[gm] => inositol-P-ceramide B (C26)[g] + diglyceride (1-16:1, 2-16:1)[gm] YDR367W and YKL004W Sphingoglycolipid metabolism +r_3470 IPC synthase (PI (1-18:0, 2-16:1) ceramide-2 (C26)) ceramide-2 (C26)[g] + 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-16:1)[gm] => inositol-P-ceramide B (C26)[g] + diglyceride (1-18:0, 2-16:1)[gm] YDR367W and YKL004W Sphingoglycolipid metabolism +r_3471 IPC synthase (PI (1-18:1, 2-16:1) ceramide-2 (C26)) ceramide-2 (C26)[g] + 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-16:1)[gm] => inositol-P-ceramide B (C26)[g] + diglyceride (1-18:1, 2-16:1)[gm] YDR367W and YKL004W Sphingoglycolipid metabolism +r_3472 IPC synthase (PI (1-16:0, 2-18:1) ceramide-2 (C26)) ceramide-2 (C26)[g] + 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-18:1)[gm] => inositol-P-ceramide B (C26)[g] + diglyceride (1-16:0, 2-18:1)[gm] YDR367W and YKL004W Sphingoglycolipid metabolism +r_3473 IPC synthase (PI (1-16:1, 2-18:1) ceramide-2 (C26)) ceramide-2 (C26)[g] + 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-18:1)[gm] => inositol-P-ceramide B (C26)[g] + diglyceride (1-16:1, 2-18:1)[gm] YDR367W and YKL004W Sphingoglycolipid metabolism +r_3474 IPC synthase (PI (1-18:0, 2-18:1) ceramide-2 (C26)) ceramide-2 (C26)[g] + 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-18:1)[gm] => inositol-P-ceramide B (C26)[g] + diglyceride (1-18:0, 2-18:1)[gm] YDR367W and YKL004W Sphingoglycolipid metabolism +r_3475 IPC synthase (PI (1-18:1, 2-18:1) ceramide-2 (C26)) ceramide-2 (C26)[g] + 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-18:1)[gm] => inositol-P-ceramide B (C26)[g] + diglyceride (1-18:1, 2-18:1)[gm] YDR367W and YKL004W Sphingoglycolipid metabolism +r_3476 IPC synthase (PI (1-16:0, 2-16:1) ceramide-3 (C24)) ceramide-3 (C24)[g] + 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-16:1)[gm] => inositol-P-ceramide C (C24)[g] + diglyceride (1-16:0, 2-16:1)[gm] YDR367W and YKL004W Sphingoglycolipid metabolism +r_3477 IPC synthase (PI (1-16:1, 2-16:1) ceramide-3 (C24)) ceramide-3 (C24)[g] + 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-16:1)[gm] => inositol-P-ceramide C (C24)[g] + diglyceride (1-16:1, 2-16:1)[gm] YDR367W and YKL004W Sphingoglycolipid metabolism +r_3478 IPC synthase (PI (1-18:0, 2-16:1) ceramide-3 (C24)) ceramide-3 (C24)[g] + 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-16:1)[gm] => inositol-P-ceramide C (C24)[g] + diglyceride (1-18:0, 2-16:1)[gm] YDR367W and YKL004W Sphingoglycolipid metabolism +r_3479 IPC synthase (PI (1-18:1, 2-16:1) ceramide-3 (C24)) ceramide-3 (C24)[g] + 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-16:1)[gm] => inositol-P-ceramide C (C24)[g] + diglyceride (1-18:1, 2-16:1)[gm] YDR367W and YKL004W Sphingoglycolipid metabolism +r_3480 IPC synthase (PI (1-16:0, 2-18:1) ceramide-3 (C24)) ceramide-3 (C24)[g] + 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-18:1)[gm] => inositol-P-ceramide C (C24)[g] + diglyceride (1-16:0, 2-18:1)[gm] YDR367W and YKL004W Sphingoglycolipid metabolism +r_3481 IPC synthase (PI (1-16:1, 2-18:1) ceramide-3 (C24)) ceramide-3 (C24)[g] + 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-18:1)[gm] => inositol-P-ceramide C (C24)[g] + diglyceride (1-16:1, 2-18:1)[gm] YDR367W and YKL004W Sphingoglycolipid metabolism +r_3482 IPC synthase (PI (1-18:0, 2-18:1) ceramide-3 (C24)) ceramide-3 (C24)[g] + 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-18:1)[gm] => inositol-P-ceramide C (C24)[g] + diglyceride (1-18:0, 2-18:1)[gm] YDR367W and YKL004W Sphingoglycolipid metabolism +r_3483 IPC synthase (PI (1-18:1, 2-18:1) ceramide-3 (C24)) ceramide-3 (C24)[g] + 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-18:1)[gm] => inositol-P-ceramide C (C24)[g] + diglyceride (1-18:1, 2-18:1)[gm] YDR367W and YKL004W Sphingoglycolipid metabolism +r_3484 IPC synthase (PI (1-16:0, 2-16:1) ceramide-3 (C26)) ceramide-3 (C26)[g] + 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-16:1)[gm] => inositol-P-ceramide C (C26)[g] + diglyceride (1-16:0, 2-16:1)[gm] YDR367W and YKL004W Sphingoglycolipid metabolism +r_3485 IPC synthase (PI (1-16:1, 2-16:1) ceramide-3 (C26)) ceramide-3 (C26)[g] + 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-16:1)[gm] => inositol-P-ceramide C (C26)[g] + diglyceride (1-16:1, 2-16:1)[gm] YDR367W and YKL004W Sphingoglycolipid metabolism +r_3486 IPC synthase (PI (1-18:0, 2-16:1) ceramide-3 (C26)) ceramide-3 (C26)[g] + 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-16:1)[gm] => inositol-P-ceramide C (C26)[g] + diglyceride (1-18:0, 2-16:1)[gm] YDR367W and YKL004W Sphingoglycolipid metabolism +r_3487 IPC synthase (PI (1-18:1, 2-16:1) ceramide-3 (C26)) ceramide-3 (C26)[g] + 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-16:1)[gm] => inositol-P-ceramide C (C26)[g] + diglyceride (1-18:1, 2-16:1)[gm] YDR367W and YKL004W Sphingoglycolipid metabolism +r_3488 IPC synthase (PI (1-16:0, 2-18:1) ceramide-3 (C26)) ceramide-3 (C26)[g] + 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-18:1)[gm] => inositol-P-ceramide C (C26)[g] + diglyceride (1-16:0, 2-18:1)[gm] YDR367W and YKL004W Sphingoglycolipid metabolism +r_3489 IPC synthase (PI (1-16:1, 2-18:1) ceramide-3 (C26)) ceramide-3 (C26)[g] + 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-18:1)[gm] => inositol-P-ceramide C (C26)[g] + diglyceride (1-16:1, 2-18:1)[gm] YDR367W and YKL004W Sphingoglycolipid metabolism +r_3490 IPC synthase (PI (1-18:0, 2-18:1) ceramide-3 (C26)) ceramide-3 (C26)[g] + 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-18:1)[gm] => inositol-P-ceramide C (C26)[g] + diglyceride (1-18:0, 2-18:1)[gm] YDR367W and YKL004W Sphingoglycolipid metabolism +r_3491 IPC synthase (PI (1-18:1, 2-18:1) ceramide-3 (C26)) ceramide-3 (C26)[g] + 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-18:1)[gm] => inositol-P-ceramide C (C26)[g] + diglyceride (1-18:1, 2-18:1)[gm] YDR367W and YKL004W Sphingoglycolipid metabolism +r_3492 IPC synthase (PI (1-16:0, 2-16:1) ceramide-4 (C24)) ceramide-4 (C24)[g] + 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-16:1)[gm] => inositol-P-ceramide D (C24)[g] + diglyceride (1-16:0, 2-16:1)[gm] YDR367W and YKL004W Sphingoglycolipid metabolism +r_3493 IPC synthase (PI (1-16:1, 2-16:1) ceramide-4 (C24)) ceramide-4 (C24)[g] + 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-16:1)[gm] => inositol-P-ceramide D (C24)[g] + diglyceride (1-16:1, 2-16:1)[gm] YDR367W and YKL004W Sphingoglycolipid metabolism +r_3494 IPC synthase (PI (1-18:0, 2-16:1) ceramide-4 (C24)) ceramide-4 (C24)[g] + 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-16:1)[gm] => inositol-P-ceramide D (C24)[g] + diglyceride (1-18:0, 2-16:1)[gm] YDR367W and YKL004W Sphingoglycolipid metabolism +r_3495 IPC synthase (PI (1-18:1, 2-16:1) ceramide-4 (C24)) ceramide-4 (C24)[g] + 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-16:1)[gm] => inositol-P-ceramide D (C24)[g] + diglyceride (1-18:1, 2-16:1)[gm] YDR367W and YKL004W Sphingoglycolipid metabolism +r_3496 IPC synthase (PI (1-16:0, 2-18:1) ceramide-4 (C24)) ceramide-4 (C24)[g] + 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-18:1)[gm] => inositol-P-ceramide D (C24)[g] + diglyceride (1-16:0, 2-18:1)[gm] YDR367W and YKL004W Sphingoglycolipid metabolism +r_3497 IPC synthase (PI (1-16:1, 2-18:1) ceramide-4 (C24)) ceramide-4 (C24)[g] + 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-18:1)[gm] => inositol-P-ceramide D (C24)[g] + diglyceride (1-16:1, 2-18:1)[gm] YDR367W and YKL004W Sphingoglycolipid metabolism +r_3498 IPC synthase (PI (1-18:0, 2-18:1) ceramide-4 (C24)) ceramide-4 (C24)[g] + 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-18:1)[gm] => inositol-P-ceramide D (C24)[g] + diglyceride (1-18:0, 2-18:1)[gm] YDR367W and YKL004W Sphingoglycolipid metabolism +r_3499 IPC synthase (PI (1-18:1, 2-18:1) ceramide-4 (C24)) ceramide-4 (C24)[g] + 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-18:1)[gm] => inositol-P-ceramide D (C24)[g] + diglyceride (1-18:1, 2-18:1)[gm] YDR367W and YKL004W Sphingoglycolipid metabolism +r_3500 IPC synthase (PI (1-16:0, 2-16:1) ceramide-4 (C26)) ceramide-4 (C26)[g] + 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-16:1)[gm] => inositol-P-ceramide D (C26)[g] + diglyceride (1-16:0, 2-16:1)[gm] YDR367W and YKL004W Sphingoglycolipid metabolism +r_3501 IPC synthase (PI (1-16:1, 2-16:1) ceramide-4 (C26)) ceramide-4 (C26)[g] + 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-16:1)[gm] => inositol-P-ceramide D (C26)[g] + diglyceride (1-16:1, 2-16:1)[gm] YDR367W and YKL004W Sphingoglycolipid metabolism +r_3502 IPC synthase (PI (1-18:0, 2-16:1) ceramide-4 (C26)) ceramide-4 (C26)[g] + 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-16:1)[gm] => inositol-P-ceramide D (C26)[g] + diglyceride (1-18:0, 2-16:1)[gm] YDR367W and YKL004W Sphingoglycolipid metabolism +r_3503 IPC synthase (PI (1-18:1, 2-16:1) ceramide-4 (C26)) ceramide-4 (C26)[g] + 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-16:1)[gm] => inositol-P-ceramide D (C26)[g] + diglyceride (1-18:1, 2-16:1)[gm] YDR367W and YKL004W Sphingoglycolipid metabolism +r_3504 IPC synthase (PI (1-16:0, 2-18:1) ceramide-4 (C26)) ceramide-4 (C26)[g] + 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-18:1)[gm] => inositol-P-ceramide D (C26)[g] + diglyceride (1-16:0, 2-18:1)[gm] YDR367W and YKL004W Sphingoglycolipid metabolism +r_3505 IPC synthase (PI (1-16:1, 2-18:1) ceramide-4 (C26)) ceramide-4 (C26)[g] + 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-18:1)[gm] => inositol-P-ceramide D (C26)[g] + diglyceride (1-16:1, 2-18:1)[gm] YDR367W and YKL004W Sphingoglycolipid metabolism +r_3506 IPC synthase (PI (1-18:0, 2-18:1) ceramide-4 (C26)) ceramide-4 (C26)[g] + 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-18:1)[gm] => inositol-P-ceramide D (C26)[g] + diglyceride (1-18:0, 2-18:1)[gm] YDR367W and YKL004W Sphingoglycolipid metabolism +r_3507 IPC synthase (PI (1-18:1, 2-18:1) ceramide-4 (C26)) ceramide-4 (C26)[g] + 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-18:1)[gm] => inositol-P-ceramide D (C26)[g] + diglyceride (1-18:1, 2-18:1)[gm] YDR367W and YKL004W Sphingoglycolipid metabolism +r_3508 laurate transport, cytoplasm-ER membrane laurate[c] <=> laurate[erm] Transport [c, erm] +r_3509 myristate transport, cytoplasm-ER membrane myristate[c] <=> myristate[erm] Transport [c, erm] +r_3510 palmitate transport, cytoplasm-ER membrane palmitate[c] <=> palmitate[erm] Transport [c, erm] +r_3511 palmitoleate transport, cytoplasm-ER membrane palmitoleate[c] <=> palmitoleate[erm] Transport [c, erm] +r_3512 stearate transport, cytoplasm-ER membrane stearate[c] <=> stearate[erm] Transport [c, erm] +r_3513 oleate transport, cytoplasm-ER membrane oleate[c] <=> oleate[erm] Transport [c, erm] +r_3514 malonyl-CoA transport, cytoplasm-ER membrane malonyl-CoA[c] <=> malonyl-CoA[erm] Transport [c, erm] +r_3515 lauroyl-CoA transport, cytoplasm-ER membrane lauroyl-CoA[c] <=> lauroyl-CoA[erm] Transport [c, erm] +r_3516 myristoyl-CoA transport, cytoplasm-ER membrane myristoyl-CoA[c] <=> myristoyl-CoA[erm] Transport [c, erm] +r_3517 palmitoyl-CoA transport, cytoplasm-ER membrane palmitoyl-CoA[c] <=> palmitoyl-CoA[erm] Transport [c, erm] +r_3518 palmitoleoyl-CoA transport, cytoplasm-ER membrane palmitoleoyl-CoA(4-)[c] <=> palmitoleoyl-CoA(4-)[erm] Transport [c, erm] +r_3519 stearoyl-CoA transport, cytoplasm-ER membrane stearoyl-CoA[c] <=> stearoyl-CoA[erm] Transport [c, erm] +r_3520 oleoyl-CoA transport, cytoplasm-ER membrane oleoyl-CoA[c] <=> oleoyl-CoA[erm] Transport [c, erm] +r_3521 icosanoyl-CoA transport, cytoplasm-ER membrane icosanoyl-CoA[c] <=> icosanoyl-CoA[erm] Transport [c, erm] +r_3522 docosanoyl-CoA transport, cytoplasm-ER membrane docosanoyl-CoA[c] <=> docosanoyl-CoA[erm] Transport [c, erm] +r_3523 tetracosanoyl-CoA transport, cytoplasm-ER membrane tetracosanoyl-CoA[c] <=> tetracosanoyl-CoA[erm] Transport [c, erm] +r_3524 hexacosanoyl-CoA transport, cytoplasm-ER membrane hexacosanoyl-CoA[c] <=> hexacosanoyl-CoA[erm] Transport [c, erm] +r_3525 H+ transport, cytoplasm-ER membrane H+[c] <=> H+[erm] Transport [c, erm] +r_3526 H2O transport, cytoplasm-ER membrane H2O[c] <=> H2O[erm] YLL052C or YPR192W Transport [c, erm] +r_3527 CO2 transport, cytoplasm-ER membrane carbon dioxide[c] <=> carbon dioxide[erm] Transport [c, erm] +r_3528 coenzyme A transport, cytoplasm-ER membrane coenzyme A[c] <=> coenzyme A[erm] Transport [c, erm] +r_3529 NADPH transport, cytoplasm-ER membrane NADPH[c] <=> NADPH[erm] Transport [c, erm] +r_3530 NADP(+) transport, cytoplasm-ER membrane NADP(+)[c] <=> NADP(+)[erm] Transport [c, erm] +r_3531 O2 transport, cytoplasm-ER membrane oxygen[c] <=> oxygen[erm] Transport [c, erm] +r_3532 NADH transport, cytoplasm-ER membrane NADH[c] <=> NADH[erm] Transport [c, erm] +r_3533 NAD transport, cytoplasm-ER membrane NAD[c] <=> NAD[erm] Transport [c, erm] +r_3534 glycerol 3-phosphate transport, cytoplasm-ER membrane glycerol 3-phosphate[c] <=> glycerol 3-phosphate[erm] Transport [c, erm] +r_3535 dihydroxyacetone phosphate transport, cytoplasm-ER membrane dihydroxyacetone phosphate[c] <=> dihydroxyacetone phosphate[erm] Transport [c, erm] +r_3536 diphosphate transport, cytoplasm-ER membrane diphosphate[c] <=> diphosphate[erm] Transport [c, erm] +r_3537 phosphate transport, cytoplasm-ER membrane phosphate[c] <=> phosphate[erm] Transport [c, erm] +r_3538 CTP transport, cytoplasm-ER membrane CTP[c] <=> CTP[erm] Transport [c, erm] +r_3539 CDP transport, cytoplasm-ER membrane CDP[c] <=> CDP[erm] Transport [c, erm] +r_3540 CMP transport, cytoplasm-ER membrane CMP[c] <=> CMP[erm] Transport [c, erm] +r_3541 CDP-ethanolamine transport, cytoplasm-ER membrane CDP-ethanolamine[c] <=> CDP-ethanolamine[erm] Transport [c, erm] +r_3542 CDP-choline transport, cytoplasm-ER membrane CDP-choline[c] <=> CDP-choline[erm] Transport [c, erm] +r_3543 ATP transport, cytoplasm-ER membrane ATP[c] <=> ATP[erm] Transport [c, erm] +r_3544 AMP transport, cytoplasm-ER membrane AMP[c] <=> AMP[erm] Transport [c, erm] +r_3545 L-serine transport, cytoplasm-ER membrane L-serine[c] <=> L-serine[erm] YKR039W Transport [c, erm] +r_3546 myo-inositol transport, cytoplasm-ER membrane myo-inositol[c] <=> myo-inositol[erm] Transport [c, erm] +r_3547 S-adenosyl-L-methionine transport, cytoplasm-ER membrane S-adenosyl-L-methionine[c] <=> S-adenosyl-L-methionine[erm] Transport [c, erm] +r_3548 S-adenosyl-L-homocysteine transport, cytoplasm-ER membrane S-adenosyl-L-homocysteine[c] <=> S-adenosyl-L-homocysteine[erm] Transport [c, erm] +r_3549 episterol transport, cytoplasm-ER membrane episterol[c] <=> episterol[erm] Transport [c, erm] +r_3550 fecosterol transport, cytoplasm-ER membrane fecosterol[c] <=> fecosterol[erm] Transport [c, erm] +r_3551 lanosterol transport, cytoplasm-ER membrane lanosterol[c] <=> lanosterol[erm] Transport [c, erm] +r_3552 ergosterol transport, cytoplasm-ER membrane ergosterol[c] <=> ergosterol[erm] Transport [c, erm] +r_3553 zymosterol transport, cytoplasm-ER membrane zymosterol[c] <=> zymosterol[erm] Transport [c, erm] +r_3554 diglyceride (1-16:0, 2-16:1) transport, cytoplasm-ER membrane diglyceride (1-16:0, 2-16:1)[c] <=> diglyceride (1-16:0, 2-16:1)[erm] Transport [c, erm] +r_3555 diglyceride (1-16:1, 2-16:1) transport, cytoplasm-ER membrane diglyceride (1-16:1, 2-16:1)[c] <=> diglyceride (1-16:1, 2-16:1)[erm] Transport [c, erm] +r_3556 diglyceride (1-18:0, 2-16:1) transport, cytoplasm-ER membrane diglyceride (1-18:0, 2-16:1)[c] <=> diglyceride (1-18:0, 2-16:1)[erm] Transport [c, erm] +r_3557 diglyceride (1-18:1, 2-16:1) transport, cytoplasm-ER membrane diglyceride (1-18:1, 2-16:1)[c] <=> diglyceride (1-18:1, 2-16:1)[erm] Transport [c, erm] +r_3558 diglyceride (1-16:0, 2-18:1) transport, cytoplasm-ER membrane diglyceride (1-16:0, 2-18:1)[c] <=> diglyceride (1-16:0, 2-18:1)[erm] Transport [c, erm] +r_3559 diglyceride (1-16:1, 2-18:1) transport, cytoplasm-ER membrane diglyceride (1-16:1, 2-18:1)[c] <=> diglyceride (1-16:1, 2-18:1)[erm] Transport [c, erm] +r_3560 diglyceride (1-18:0, 2-18:1) transport, cytoplasm-ER membrane diglyceride (1-18:0, 2-18:1)[c] <=> diglyceride (1-18:0, 2-18:1)[erm] Transport [c, erm] +r_3561 diglyceride (1-18:1, 2-18:1) transport, cytoplasm-ER membrane diglyceride (1-18:1, 2-18:1)[c] <=> diglyceride (1-18:1, 2-18:1)[erm] Transport [c, erm] +r_3562 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-16:1) transport, cytoplasm-ER membrane 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-16:1)[c] <=> 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-16:1)[erm] Transport [c, erm] +r_3563 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-16:1) transport, cytoplasm-ER membrane 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-16:1)[c] <=> 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-16:1)[erm] Transport [c, erm] +r_3564 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-16:1) transport, cytoplasm-ER membrane 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-16:1)[c] <=> 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-16:1)[erm] Transport [c, erm] +r_3565 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-16:1) transport, cytoplasm-ER membrane 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-16:1)[c] <=> 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-16:1)[erm] Transport [c, erm] +r_3566 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-18:1) transport, cytoplasm-ER membrane 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-18:1)[c] <=> 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-18:1)[erm] Transport [c, erm] +r_3567 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-18:1) transport, cytoplasm-ER membrane 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-18:1)[c] <=> 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-18:1)[erm] Transport [c, erm] +r_3568 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-18:1) transport, cytoplasm-ER membrane 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-18:1)[c] <=> 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-18:1)[erm] Transport [c, erm] +r_3569 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-18:1) transport, cytoplasm-ER membrane 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-18:1)[c] <=> 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-18:1)[erm] Transport [c, erm] +r_3570 sn-glycero-3-phosphocholine transport, ER membrane-cytoplasm sn-glycero-3-phosphocholine[erm] <=> sn-glycero-3-phosphocholine[c] Transport [c, erm] +r_3571 hexadecanoate (n-C16:0) transport, cytoplasm-lipid particle palmitate[c] <=> palmitate[lp] Transport [c, lp] +r_3572 hexadecenoate (n-C16:1) transport, cytoplasm-lipid particle palmitoleate[c] <=> palmitoleate[lp] Transport [c, lp] +r_3573 octadecanoate (n-C18:0) transport, cytoplasm-lipid particle stearate[c] <=> stearate[lp] Transport [c, lp] +r_3574 octadecenoate (n-C18:1) transport, cytoplasm-lipid particle oleate[c] <=> oleate[lp] Transport [c, lp] +r_3575 lauroyl-CoA transport, cytoplasm-lipid particle lauroyl-CoA[c] <=> lauroyl-CoA[lp] Transport [c, lp] +r_3576 myristoyl-CoA transport, cytoplasm-lipid particle myristoyl-CoA[c] <=> myristoyl-CoA[lp] Transport [c, lp] +r_3577 palmitoyl-CoA transport, cytoplasm-lipid particle palmitoyl-CoA[c] <=> palmitoyl-CoA[lp] Transport [c, lp] +r_3578 palmitoleoyl-CoA transport, cytoplasm-lipid particle palmitoleoyl-CoA(4-)[c] <=> palmitoleoyl-CoA(4-)[lp] Transport [c, lp] +r_3579 stearoyl-CoA transport, cytoplasm-lipid particle stearoyl-CoA[c] <=> stearoyl-CoA[lp] Transport [c, lp] +r_3580 oleoyl-CoA transport, cytoplasm-lipid particle oleoyl-CoA[c] <=> oleoyl-CoA[lp] Transport [c, lp] +r_3581 glycerol 3-phosphate transport, cytoplasm-lipid particle glycerol 3-phosphate[c] <=> glycerol 3-phosphate[lp] Transport [c, lp] +r_3582 dihydroxyacetone phosphate transport, cytoplasm-lipid particle dihydroxyacetone phosphate[c] <=> dihydroxyacetone phosphate[lp] Transport [c, lp] +r_3583 NADPH transport, cytoplasm-lipid particle NADPH[c] <=> NADPH[lp] Transport [c, lp] +r_3584 NADP(+) transport, cytoplasm-lipid particle NADP(+)[c] <=> NADP(+)[lp] Transport [c, lp] +r_3585 ATP transport, cytoplasm-lipid particle ATP[c] <=> ATP[lp] Transport [c, lp] +r_3586 AMP transport, cytoplasm-lipid particle AMP[c] <=> AMP[lp] Transport [c, lp] +r_3587 diphosphate transport, cytoplasm-lipid particle diphosphate[c] <=> diphosphate[lp] Transport [c, lp] +r_3588 diglyceride (1-16:0, 2-16:1) transport, cytoplasm-lipid particle diglyceride (1-16:0, 2-16:1)[c] <=> diglyceride (1-16:0, 2-16:1)[lp] Transport [c, lp] +r_3589 diglyceride (1-16:1, 2-16:1) transport, cytoplasm-lipid particle diglyceride (1-16:1, 2-16:1)[c] <=> diglyceride (1-16:1, 2-16:1)[lp] Transport [c, lp] +r_3590 diglyceride (1-18:0, 2-16:1) transport, cytoplasm-lipid particle diglyceride (1-18:0, 2-16:1)[c] <=> diglyceride (1-18:0, 2-16:1)[lp] Transport [c, lp] +r_3591 diglyceride (1-18:1, 2-16:1) transport, cytoplasm-lipid particle diglyceride (1-18:1, 2-16:1)[c] <=> diglyceride (1-18:1, 2-16:1)[lp] Transport [c, lp] +r_3592 diglyceride (1-16:0, 2-18:1) transport, cytoplasm-lipid particle diglyceride (1-16:0, 2-18:1)[c] <=> diglyceride (1-16:0, 2-18:1)[lp] Transport [c, lp] +r_3593 diglyceride (1-16:1, 2-18:1) transport, cytoplasm-lipid particle diglyceride (1-16:1, 2-18:1)[c] <=> diglyceride (1-16:1, 2-18:1)[lp] Transport [c, lp] +r_3594 diglyceride (1-18:0, 2-18:1) transport, cytoplasm-lipid particle diglyceride (1-18:0, 2-18:1)[c] <=> diglyceride (1-18:0, 2-18:1)[lp] Transport [c, lp] +r_3595 diglyceride (1-18:1, 2-18:1) transport, cytoplasm-lipid particle diglyceride (1-18:1, 2-18:1)[c] <=> diglyceride (1-18:1, 2-18:1)[lp] Transport [c, lp] +r_3596 H2O transport, cytoplasm-lipid particle H2O[c] <=> H2O[lp] Transport [c, lp] +r_3597 glycerol transport, lipid particle-cytoplasm glycerol[lp] <=> glycerol[c] Transport [c, lp] +r_3598 docosanoyl-CoA transport, lipid particle-cytoplasm docosanoyl-CoA[lp] <=> docosanoyl-CoA[c] Transport [c, lp] +r_3599 tetracosanoyl-CoA transport, lipid particle-cytoplasm tetracosanoyl-CoA[lp] <=> tetracosanoyl-CoA[c] Transport [c, lp] +r_3600 hexacosanoyl-CoA transport, lipid particle-cytoplasm hexacosanoyl-CoA[lp] <=> hexacosanoyl-CoA[c] Transport [c, lp] +r_3601 ATP transport, cytoplasm-cell envelope ATP[c] <=> ATP[ce] Transport [c, ce] +r_3602 ADP transport, cytoplasm-cell envelope ADP[c] <=> ADP[ce] Transport [c, ce] +r_3603 H+ transport, cytoplasm-cell envelope H+[c] <=> H+[ce] Transport [c, ce] +r_3604 H2O transport, cytoplasm-cell envelope H2O[c] <=> H2O[ce] YLL052C or YLL053C or YPR192W Transport [c, ce] +r_3605 phosphate transport, cytoplasm-cell envelope phosphate[c] <=> phosphate[ce] YCR037C or YJL198W or YML123C Transport [c, ce] +r_3606 sn-glycero-3-phosphocholine transport, cell envelope-cytoplasm sn-glycero-3-phosphocholine[ce] <=> sn-glycero-3-phosphocholine[c] YCR098C Transport [c, ce] +r_3607 1-(sn-glycero-3-phospho)-1D-myo-inositol transport, cell envelope-cytoplasm 1-(sn-glycero-3-phospho)-1D-myo-inositol[ce] <=> 1-(sn-glycero-3-phospho)-1D-myo-inositol[c] YCR098C Transport [c, ce] +r_3608 palmitate transport, cell envelope-cytoplasm palmitate[ce] <=> palmitate[c] Transport [c, ce] +r_3609 palmitoleate transport, cell envelope-cytoplasm palmitoleate[ce] <=> palmitoleate[c] Transport [c, ce] +r_3610 stearate transport, cell envelope-cytoplasm stearate[ce] <=> stearate[c] Transport [c, ce] +r_3611 oleate transport, cell envelope-cytoplasm oleate[ce] <=> oleate[c] Transport [c, ce] +r_3612 icosanoyl-CoA transport, cell envelope-cytoplasm icosanoyl-CoA[ce] <=> icosanoyl-CoA[c] Transport [c, ce] +r_3613 docosanoyl-CoA transport, cell envelope-cytoplasm docosanoyl-CoA[ce] <=> docosanoyl-CoA[c] Transport [c, ce] +r_3614 tetracosanoyl-CoA transport, cell envelope-cytoplasm tetracosanoyl-CoA[ce] <=> tetracosanoyl-CoA[c] Transport [c, ce] +r_3615 hexacosanoyl-CoA transport, cell envelope-cytoplasm hexacosanoyl-CoA[ce] <=> hexacosanoyl-CoA[c] Transport [c, ce] +r_3616 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-16:0, 2-16:1) transport, cell envelope-cytoplasm 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-16:0, 2-16:1)[ce] <=> 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-16:0, 2-16:1)[c] Transport [c, ce] +r_3617 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-16:1, 2-16:1) transport, cell envelope-cytoplasm 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-16:1, 2-16:1)[ce] <=> 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-16:1, 2-16:1)[c] Transport [c, ce] +r_3618 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-18:0, 2-16:1) transport, cell envelope-cytoplasm 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-18:0, 2-16:1)[ce] <=> 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-18:0, 2-16:1)[c] Transport [c, ce] +r_3619 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-18:1, 2-16:1) transport, cell envelope-cytoplasm 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-18:1, 2-16:1)[ce] <=> 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-18:1, 2-16:1)[c] Transport [c, ce] +r_3620 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-16:0, 2-18:1) transport, cell envelope-cytoplasm 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-16:0, 2-18:1)[ce] <=> 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-16:0, 2-18:1)[c] Transport [c, ce] +r_3621 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-16:1, 2-18:1) transport, cell envelope-cytoplasm 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-16:1, 2-18:1)[ce] <=> 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-16:1, 2-18:1)[c] Transport [c, ce] +r_3622 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-18:0, 2-18:1) transport, cell envelope-cytoplasm 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-18:0, 2-18:1)[ce] <=> 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-18:0, 2-18:1)[c] Transport [c, ce] +r_3623 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-18:1, 2-18:1) transport, cell envelope-cytoplasm 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-18:1, 2-18:1)[ce] <=> 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-18:1, 2-18:1)[c] Transport [c, ce] +r_3624 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-16:0, 2-16:1) transport, cell envelope-cytoplasm 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-16:0, 2-16:1)[ce] <=> 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-16:0, 2-16:1)[c] Transport [c, ce] +r_3625 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-16:1, 2-16:1) transport, cell envelope-cytoplasm 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-16:1, 2-16:1)[ce] <=> 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-16:1, 2-16:1)[c] Transport [c, ce] +r_3626 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-18:0, 2-16:1) transport, cell envelope-cytoplasm 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-18:0, 2-16:1)[ce] <=> 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-18:0, 2-16:1)[c] Transport [c, ce] +r_3627 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-18:1, 2-16:1) transport, cell envelope-cytoplasm 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-18:1, 2-16:1)[ce] <=> 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-18:1, 2-16:1)[c] Transport [c, ce] +r_3628 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-16:0, 2-18:1) transport, cell envelope-cytoplasm 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-16:0, 2-18:1)[ce] <=> 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-16:0, 2-18:1)[c] Transport [c, ce] +r_3629 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-16:1, 2-18:1) transport, cell envelope-cytoplasm 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-16:1, 2-18:1)[ce] <=> 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-16:1, 2-18:1)[c] Transport [c, ce] +r_3630 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-18:0, 2-18:1) transport, cell envelope-cytoplasm 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-18:0, 2-18:1)[ce] <=> 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-18:0, 2-18:1)[c] Transport [c, ce] +r_3631 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-18:1, 2-18:1) transport, cell envelope-cytoplasm 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-18:1, 2-18:1)[ce] <=> 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-18:1, 2-18:1)[c] Transport [c, ce] +r_3632 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-16:0, 2-16:1) transport, nucleus-cytoplasm 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-16:0, 2-16:1)[n] <=> 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-16:0, 2-16:1)[c] Transport [c, n] +r_3633 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-16:1, 2-16:1) transport, nucleus-cytoplasm 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-16:1, 2-16:1)[n] <=> 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-16:1, 2-16:1)[c] Transport [c, n] +r_3634 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-18:0, 2-16:1) transport, nucleus-cytoplasm 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-18:0, 2-16:1)[n] <=> 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-18:0, 2-16:1)[c] Transport [c, n] +r_3635 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-18:1, 2-16:1) transport, nucleus-cytoplasm 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-18:1, 2-16:1)[n] <=> 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-18:1, 2-16:1)[c] Transport [c, n] +r_3636 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-16:0, 2-18:1) transport, nucleus-cytoplasm 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-16:0, 2-18:1)[n] <=> 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-16:0, 2-18:1)[c] Transport [c, n] +r_3637 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-16:1, 2-18:1) transport, nucleus-cytoplasm 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-16:1, 2-18:1)[n] <=> 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-16:1, 2-18:1)[c] Transport [c, n] +r_3638 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-18:0, 2-18:1) transport, nucleus-cytoplasm 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-18:0, 2-18:1)[n] <=> 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-18:0, 2-18:1)[c] Transport [c, n] +r_3639 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-18:1, 2-18:1) transport, nucleus-cytoplasm 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-18:1, 2-18:1)[n] <=> 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-18:1, 2-18:1)[c] Transport [c, n] +r_3640 diglyceride (1-16:0, 2-16:1) transport, nucleus-cytoplasm diglyceride (1-16:0, 2-16:1)[n] <=> diglyceride (1-16:0, 2-16:1)[c] Transport [c, n] +r_3641 diglyceride (1-16:1, 2-16:1) transport, nucleus-cytoplasm diglyceride (1-16:1, 2-16:1)[n] <=> diglyceride (1-16:1, 2-16:1)[c] Transport [c, n] +r_3642 diglyceride (1-18:0, 2-16:1) transport, nucleus-cytoplasm diglyceride (1-18:0, 2-16:1)[n] <=> diglyceride (1-18:0, 2-16:1)[c] Transport [c, n] +r_3643 diglyceride (1-18:1, 2-16:1) transport, nucleus-cytoplasm diglyceride (1-18:1, 2-16:1)[n] <=> diglyceride (1-18:1, 2-16:1)[c] Transport [c, n] +r_3644 diglyceride (1-16:0, 2-18:1) transport, nucleus-cytoplasm diglyceride (1-16:0, 2-18:1)[n] <=> diglyceride (1-16:0, 2-18:1)[c] Transport [c, n] +r_3645 diglyceride (1-16:1, 2-18:1) transport, nucleus-cytoplasm diglyceride (1-16:1, 2-18:1)[n] <=> diglyceride (1-16:1, 2-18:1)[c] Transport [c, n] +r_3646 diglyceride (1-18:0, 2-18:1) transport, nucleus-cytoplasm diglyceride (1-18:0, 2-18:1)[n] <=> diglyceride (1-18:0, 2-18:1)[c] Transport [c, n] +r_3647 diglyceride (1-18:1, 2-18:1) transport, nucleus-cytoplasm diglyceride (1-18:1, 2-18:1)[n] <=> diglyceride (1-18:1, 2-18:1)[c] Transport [c, n] +r_3648 H2O transport, cytoplasm-vacuolar membrane H2O[c] <=> H2O[vm] Transport [c, vm] +r_3649 phosphate transport, cytoplasm-vacuolar membrane phosphate[c] <=> phosphate[vm] YNR013C Transport [c, vm] +r_3650 H+ transport, cytoplasm-vacuolar membrane H+[c] <=> H+[vm] Transport [c, vm] +r_3651 ATP transport, cytoplasm-vacuolar membrane ATP[c] <=> ATP[vm] Transport [c, vm] +r_3652 ADP transport, cytoplasm-vacuolar membrane ADP[c] <=> ADP[vm] Transport [c, vm] +r_3653 carbon dioxide transport, cytoplasm-vacuolar membrane carbon dioxide[c] <=> carbon dioxide[vm] Transport [c, vm] +r_3654 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-16:0, 2-16:1) transport, vacuolar membrane-cytoplasm 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-16:0, 2-16:1)[vm] <=> 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-16:0, 2-16:1)[c] Transport [c, vm] +r_3655 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-16:1, 2-16:1) transport, vacuolar membrane-cytoplasm 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-16:1, 2-16:1)[vm] <=> 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-16:1, 2-16:1)[c] Transport [c, vm] +r_3656 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-18:0, 2-16:1) transport, vacuolar membrane-cytoplasm 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-18:0, 2-16:1)[vm] <=> 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-18:0, 2-16:1)[c] Transport [c, vm] +r_3657 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-18:1, 2-16:1) transport, vacuolar membrane-cytoplasm 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-18:1, 2-16:1)[vm] <=> 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-18:1, 2-16:1)[c] Transport [c, vm] +r_3658 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-16:0, 2-18:1) transport, vacuolar membrane-cytoplasm 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-16:0, 2-18:1)[vm] <=> 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-16:0, 2-18:1)[c] Transport [c, vm] +r_3659 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-16:1, 2-18:1) transport, vacuolar membrane-cytoplasm 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-16:1, 2-18:1)[vm] <=> 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-16:1, 2-18:1)[c] Transport [c, vm] +r_3660 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-18:0, 2-18:1) transport, vacuolar membrane-cytoplasm 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-18:0, 2-18:1)[vm] <=> 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-18:0, 2-18:1)[c] Transport [c, vm] +r_3661 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-18:1, 2-18:1) transport, vacuolar membrane-cytoplasm 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-18:1, 2-18:1)[vm] <=> 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-18:1, 2-18:1)[c] Transport [c, vm] +r_3662 H2O transport, cytoplasm-Golgi membrane H2O[c] <=> H2O[gm] Transport [c, gm] +r_3663 phosphate transport, cytoplasm-Golgi membrane phosphate[c] <=> phosphate[gm] Transport [c, gm] +r_3664 H+ transport, cytoplasm-Golgi membrane H+[c] <=> H+[gm] Transport [c, gm] +r_3665 carbon dioxide transport, cytoplasm-Golgi membrane carbon dioxide[c] <=> carbon dioxide[gm] Transport [c, gm] +r_3666 ATP transport, cytoplasm-Golgi membrane ATP[c] <=> ATP[gm] Transport [c, gm] +r_3667 ADP transport, cytoplasm-Golgi membrane ADP[c] <=> ADP[gm] Transport [c, gm] +r_3668 H2O transport, cytoplasm-mitochondrial membrane H2O[c] <=> H2O[mm] Transport [c, mm] +r_3669 carbon dioxide transport, cytoplasm-mitochondrial membrane carbon dioxide[c] <=> carbon dioxide[mm] Transport [c, mm] +r_3670 palmitoleoyl-CoA transport, cytoplasm-mitochondrial membrane palmitoleoyl-CoA(4-)[c] <=> palmitoleoyl-CoA(4-)[mm] Transport [c, mm] +r_3671 oleoyl-CoA transport, cytoplasm-mitochondrial membrane oleoyl-CoA[c] <=> oleoyl-CoA[mm] Transport [c, mm] +r_3672 diglyceride (1-16:0, 2-16:1) transport, mitochondrial membrane-cytoplasm diglyceride (1-16:0, 2-16:1)[mm] <=> diglyceride (1-16:0, 2-16:1)[c] Transport [c, mm] +r_3673 diglyceride (1-16:1, 2-16:1) transport, mitochondrial membrane-cytoplasm diglyceride (1-16:1, 2-16:1)[mm] <=> diglyceride (1-16:1, 2-16:1)[c] Transport [c, mm] +r_3674 diglyceride (1-18:0, 2-16:1) transport, mitochondrial membrane-cytoplasm diglyceride (1-18:0, 2-16:1)[mm] <=> diglyceride (1-18:0, 2-16:1)[c] Transport [c, mm] +r_3675 diglyceride (1-18:1, 2-16:1) transport, mitochondrial membrane-cytoplasm diglyceride (1-18:1, 2-16:1)[mm] <=> diglyceride (1-18:1, 2-16:1)[c] Transport [c, mm] +r_3676 diglyceride (1-16:0, 2-18:1) transport, mitochondrial membrane-cytoplasm diglyceride (1-16:0, 2-18:1)[mm] <=> diglyceride (1-16:0, 2-18:1)[c] Transport [c, mm] +r_3677 diglyceride (1-16:1, 2-18:1) transport, mitochondrial membrane-cytoplasm diglyceride (1-16:1, 2-18:1)[mm] <=> diglyceride (1-16:1, 2-18:1)[c] Transport [c, mm] +r_3678 palmitate transport, mitochondrial membrane-cytoplasm palmitate[mm] <=> palmitate[c] Transport [c, mm] +r_3679 stearate transport, mitochondrial membrane-cytoplasm stearate[mm] <=> stearate[c] Transport [c, mm] +r_3680 coenzyme A transport, mitochondrial membrane-cytoplasm coenzyme A[mm] <=> coenzyme A[c] YHR002W Transport [c, mm] +r_3681 laurate transport, ER membrane-lipid particle laurate[erm] <=> laurate[lp] Transport [erm, lp] +r_3682 myristate transport, ER membrane-lipid particle myristate[erm] <=> myristate[lp] Transport [erm, lp] +r_3683 lignoceric acid transport, ER membrane-lipid particle lignoceric acid[erm] <=> lignoceric acid[lp] Transport [erm, lp] +r_3684 cerotic acid transport, ER membrane-lipid particle cerotic acid[erm] <=> cerotic acid[lp] Transport [erm, lp] +r_3685 TAG (1-16:0, 2-16:1, 3-16:0) transport, ER membrane-lipid particle triglyceride (1-16:0, 2-16:1, 3-16:0)[erm] <=> triglyceride (1-16:0, 2-16:1, 3-16:0)[lp] Transport [erm, lp] +r_3686 TAG (1-16:0, 2-16:1, 3-16:1) transport, ER membrane-lipid particle triglyceride (1-16:0, 2-16:1, 3-16:1)[erm] <=> triglyceride (1-16:0, 2-16:1, 3-16:1)[lp] Transport [erm, lp] +r_3687 TAG (1-16:0, 2-16:1, 3-18:0) transport, ER membrane-lipid particle triglyceride (1-16:0, 2-16:1, 3-18:0)[erm] <=> triglyceride (1-16:0, 2-16:1, 3-18:0)[lp] Transport [erm, lp] +r_3688 TAG (1-16:0, 2-16:1, 3-18:1) transport, ER membrane-lipid particle triglyceride (1-16:0, 2-16:1, 3-18:1)[erm] <=> triglyceride (1-16:0, 2-16:1, 3-18:1)[lp] Transport [erm, lp] +r_3689 TAG (1-16:1, 2-16:1, 3-16:0) transport, ER membrane-lipid particle triglyceride (1-16:1, 2-16:1, 3-16:0)[erm] <=> triglyceride (1-16:1, 2-16:1, 3-16:0)[lp] Transport [erm, lp] +r_3690 TAG (1-16:1, 2-16:1, 3-16:1) transport, ER membrane-lipid particle triglyceride (1-16:1, 2-16:1, 3-16:1)[erm] <=> triglyceride (1-16:1, 2-16:1, 3-16:1)[lp] Transport [erm, lp] +r_3691 TAG (1-16:1, 2-16:1, 3-18:0) transport, ER membrane-lipid particle triglyceride (1-16:1, 2-16:1, 3-18:0)[erm] <=> triglyceride (1-16:1, 2-16:1, 3-18:0)[lp] Transport [erm, lp] +r_3692 TAG (1-16:1, 2-16:1, 3-18:1) transport, ER membrane-lipid particle triglyceride (1-16:1, 2-16:1, 3-18:1)[erm] <=> triglyceride (1-16:1, 2-16:1, 3-18:1)[lp] Transport [erm, lp] +r_3693 TAG (1-18:0, 2-16:1, 3-16:0) transport, ER membrane-lipid particle triglyceride (1-18:0, 2-16:1, 3-16:0)[erm] <=> triglyceride (1-18:0, 2-16:1, 3-16:0)[lp] Transport [erm, lp] +r_3694 TAG (1-18:0, 2-16:1, 3-16:1) transport, ER membrane-lipid particle triglyceride (1-18:0, 2-16:1, 3-16:1)[erm] <=> triglyceride (1-18:0, 2-16:1, 3-16:1)[lp] Transport [erm, lp] +r_3695 TAG (1-18:0, 2-16:1, 3-18:0) transport, ER membrane-lipid particle triglyceride (1-18:0, 2-16:1, 3-18:0)[erm] <=> triglyceride (1-18:0, 2-16:1, 3-18:0)[lp] Transport [erm, lp] +r_3696 TAG (1-18:0, 2-16:1, 3-18:1) transport, ER membrane-lipid particle triglyceride (1-18:0, 2-16:1, 3-18:1)[erm] <=> triglyceride (1-18:0, 2-16:1, 3-18:1)[lp] Transport [erm, lp] +r_3697 TAG (1-18:1, 2-16:1, 3-16:0) transport, ER membrane-lipid particle triglyceride (1-18:1, 2-16:1, 3-16:0)[erm] <=> triglyceride (1-18:1, 2-16:1, 3-16:0)[lp] Transport [erm, lp] +r_3698 TAG (1-18:1, 2-16:1, 3-16:1) transport, ER membrane-lipid particle triglyceride (1-18:1, 2-16:1, 3-16:1)[erm] <=> triglyceride (1-18:1, 2-16:1, 3-16:1)[lp] Transport [erm, lp] +r_3699 TAG (1-18:1, 2-16:1, 3-18:0) transport, ER membrane-lipid particle triglyceride (1-18:1, 2-16:1, 3-18:0)[erm] <=> triglyceride (1-18:1, 2-16:1, 3-18:0)[lp] Transport [erm, lp] +r_3700 TAG (1-18:1, 2-16:1, 3-18:1) transport, ER membrane-lipid particle triglyceride (1-18:1, 2-16:1, 3-18:1)[erm] <=> triglyceride (1-18:1, 2-16:1, 3-18:1)[lp] Transport [erm, lp] +r_3701 TAG (1-16:0, 2-18:1, 3-16:0) transport, ER membrane-lipid particle triglyceride (1-16:0, 2-18:1, 3-16:0)[erm] <=> triglyceride (1-16:0, 2-18:1, 3-16:0)[lp] Transport [erm, lp] +r_3702 TAG (1-16:0, 2-18:1, 3-16:1) transport, ER membrane-lipid particle triglyceride (1-16:0, 2-18:1, 3-16:1)[erm] <=> triglyceride (1-16:0, 2-18:1, 3-16:1)[lp] Transport [erm, lp] +r_3703 TAG (1-16:0, 2-18:1, 3-18:0) transport, ER membrane-lipid particle triglyceride (1-16:0, 2-18:1, 3-18:0)[erm] <=> triglyceride (1-16:0, 2-18:1, 3-18:0)[lp] Transport [erm, lp] +r_3704 TAG (1-16:0, 2-18:1, 3-18:1) transport, ER membrane-lipid particle triglyceride (1-16:0, 2-18:1, 3-18:1)[erm] <=> triglyceride (1-16:0, 2-18:1, 3-18:1)[lp] Transport [erm, lp] +r_3705 TAG (1-16:1, 2-18:1, 3-16:0) transport, ER membrane-lipid particle triglyceride (1-16:1, 2-18:1, 3-16:0)[erm] <=> triglyceride (1-16:1, 2-18:1, 3-16:0)[lp] Transport [erm, lp] +r_3706 TAG (1-16:1, 2-18:1, 3-16:1) transport, ER membrane-lipid particle triglyceride (1-16:1, 2-18:1, 3-16:1)[erm] <=> triglyceride (1-16:1, 2-18:1, 3-16:1)[lp] Transport [erm, lp] +r_3707 TAG (1-16:1, 2-18:1, 3-18:0) transport, ER membrane-lipid particle triglyceride (1-16:1, 2-18:1, 3-18:0)[erm] <=> triglyceride (1-16:1, 2-18:1, 3-18:0)[lp] Transport [erm, lp] +r_3708 TAG (1-16:1, 2-18:1, 3-18:1) transport, ER membrane-lipid particle triglyceride (1-16:1, 2-18:1, 3-18:1)[erm] <=> triglyceride (1-16:1, 2-18:1, 3-18:1)[lp] Transport [erm, lp] +r_3709 TAG (1-18:0, 2-18:1, 3-16:0) transport, ER membrane-lipid particle triglyceride (1-18:0, 2-18:1, 3-16:0)[erm] <=> triglyceride (1-18:0, 2-18:1, 3-16:0)[lp] Transport [erm, lp] +r_3710 TAG (1-18:0, 2-18:1, 3-16:1) transport, ER membrane-lipid particle triglyceride (1-18:0, 2-18:1, 3-16:1)[erm] <=> triglyceride (1-18:0, 2-18:1, 3-16:1)[lp] Transport [erm, lp] +r_3711 TAG (1-18:0, 2-18:1, 3-18:0) transport, ER membrane-lipid particle triglyceride (1-18:0, 2-18:1, 3-18:0)[erm] <=> triglyceride (1-18:0, 2-18:1, 3-18:0)[lp] Transport [erm, lp] +r_3712 TAG (1-18:0, 2-18:1, 3-18:1) transport, ER membrane-lipid particle triglyceride (1-18:0, 2-18:1, 3-18:1)[erm] <=> triglyceride (1-18:0, 2-18:1, 3-18:1)[lp] Transport [erm, lp] +r_3713 TAG (1-18:1, 2-18:1, 3-16:0) transport, ER membrane-lipid particle triglyceride (1-18:1, 2-18:1, 3-16:0)[erm] <=> triglyceride (1-18:1, 2-18:1, 3-16:0)[lp] Transport [erm, lp] +r_3714 TAG (1-18:1, 2-18:1, 3-16:1) transport, ER membrane-lipid particle triglyceride (1-18:1, 2-18:1, 3-16:1)[erm] <=> triglyceride (1-18:1, 2-18:1, 3-16:1)[lp] Transport [erm, lp] +r_3715 TAG (1-18:1, 2-18:1, 3-18:0) transport, ER membrane-lipid particle triglyceride (1-18:1, 2-18:1, 3-18:0)[erm] <=> triglyceride (1-18:1, 2-18:1, 3-18:0)[lp] Transport [erm, lp] +r_3716 TAG (1-18:1, 2-18:1, 3-18:1) transport, ER membrane-lipid particle triglyceride (1-18:1, 2-18:1, 3-18:1)[erm] <=> triglyceride (1-18:1, 2-18:1, 3-18:1)[lp] Transport [erm, lp] +r_3717 episterol transport, ER membrane-lipid particle episterol[erm] <=> episterol[lp] Transport [erm, lp] +r_3718 fecosterol transport, ER membrane-lipid particle fecosterol[erm] <=> fecosterol[lp] Transport [erm, lp] +r_3719 lanosterol transport, ER membrane-lipid particle lanosterol[erm] <=> lanosterol[lp] Transport [erm, lp] +r_3720 zymosterol transport, ER membrane-lipid particle zymosterol[erm] <=> zymosterol[lp] Transport [erm, lp] +r_3721 ergosteryl palmitoleate transport, ER membrane-lipid particle ergosteryl palmitoleate[erm] <=> ergosteryl palmitoleate[lp] Transport [erm, lp] +r_3722 ergosteryl oleate transport, ER membrane-lipid particle ergosteryl oleate[erm] <=> ergosteryl oleate[lp] Transport [erm, lp] +r_3723 episteryl palmitoleate transport, ER membrane-lipid particle episteryl palmitoleate[erm] <=> episteryl palmitoleate[lp] Transport [erm, lp] +r_3724 episteryl oleate transport, ER membrane-lipid particle episteryl oleate[erm] <=> episteryl oleate[lp] Transport [erm, lp] +r_3725 fecosteryl palmitoleate transport, ER membrane-lipid particle fecosteryl palmitoleate[erm] <=> fecosteryl palmitoleate[lp] Transport [erm, lp] +r_3726 fecosteryl oleate transport, ER membrane-lipid particle fecosteryl oleate[erm] <=> fecosteryl oleate[lp] Transport [erm, lp] +r_3727 lanosteryl palmitoleate transport, ER membrane-lipid particle lanosteryl palmitoleate[erm] <=> lanosteryl palmitoleate[lp] Transport [erm, lp] +r_3728 lanosteryl oleate transport, ER membrane-lipid particle lanosteryl oleate[erm] <=> lanosteryl oleate[lp] Transport [erm, lp] +r_3729 zymosteryl palmitoleate transport, ER membrane-lipid particle zymosteryl palmitoleate[erm] <=> zymosteryl palmitoleate[lp] Transport [erm, lp] +r_3730 zymosteryl oleate transport, ER membrane-lipid particle zymosteryl oleate[erm] <=> zymosteryl oleate[lp] Transport [erm, lp] +r_3731 phosphatidylcholine (1-16:0, 2-16:1) transport, ER membrane-lipid particle phosphatidylcholine (1-16:0, 2-16:1)[erm] <=> phosphatidylcholine (1-16:0, 2-16:1)[lp] Transport [erm, lp] +r_3732 phosphatidylcholine (1-16:1, 2-16:1) transport, ER membrane-lipid particle phosphatidylcholine (1-16:1, 2-16:1)[erm] <=> phosphatidylcholine (1-16:1, 2-16:1)[lp] Transport [erm, lp] +r_3733 phosphatidylcholine (1-18:0, 2-16:1) transport, ER membrane-lipid particle phosphatidylcholine (1-18:0, 2-16:1)[erm] <=> phosphatidylcholine (1-18:0, 2-16:1)[lp] Transport [erm, lp] +r_3734 phosphatidylcholine (1-18:1, 2-16:1) transport, ER membrane-lipid particle phosphatidylcholine (1-18:1, 2-16:1)[erm] <=> phosphatidylcholine (1-18:1, 2-16:1)[lp] Transport [erm, lp] +r_3735 phosphatidylcholine (1-16:0, 2-18:1) transport, ER membrane-lipid particle phosphatidylcholine (1-16:0, 2-18:1)[erm] <=> phosphatidylcholine (1-16:0, 2-18:1)[lp] Transport [erm, lp] +r_3736 phosphatidylcholine (1-16:1, 2-18:1) transport, ER membrane-lipid particle phosphatidylcholine (1-16:1, 2-18:1)[erm] <=> phosphatidylcholine (1-16:1, 2-18:1)[lp] Transport [erm, lp] +r_3737 phosphatidylcholine (1-18:0, 2-18:1) transport, ER membrane-lipid particle phosphatidylcholine (1-18:0, 2-18:1)[erm] <=> phosphatidylcholine (1-18:0, 2-18:1)[lp] Transport [erm, lp] +r_3738 phosphatidylcholine (1-18:1, 2-18:1) transport, ER membrane-lipid particle phosphatidylcholine (1-18:1, 2-18:1)[erm] <=> phosphatidylcholine (1-18:1, 2-18:1)[lp] Transport [erm, lp] +r_3739 phosphatidylethanolamine (1-16:0, 2-16:1) transport, ER membrane-lipid particle phosphatidylethanolamine (1-16:0, 2-16:1)[erm] <=> phosphatidylethanolamine (1-16:0, 2-16:1)[lp] Transport [erm, lp] +r_3740 phosphatidylethanolamine (1-16:1, 2-16:1) transport, ER membrane-lipid particle phosphatidylethanolamine (1-16:1, 2-16:1)[erm] <=> phosphatidylethanolamine (1-16:1, 2-16:1)[lp] Transport [erm, lp] +r_3741 phosphatidylethanolamine (1-18:0, 2-16:1) transport, ER membrane-lipid particle phosphatidylethanolamine (1-18:0, 2-16:1)[erm] <=> phosphatidylethanolamine (1-18:0, 2-16:1)[lp] Transport [erm, lp] +r_3742 phosphatidylethanolamine (1-18:1, 2-16:1) transport, ER membrane-lipid particle phosphatidylethanolamine (1-18:1, 2-16:1)[erm] <=> phosphatidylethanolamine (1-18:1, 2-16:1)[lp] Transport [erm, lp] +r_3743 phosphatidylethanolamine (1-16:0, 2-18:1) transport, ER membrane-lipid particle phosphatidylethanolamine (1-16:0, 2-18:1)[erm] <=> phosphatidylethanolamine (1-16:0, 2-18:1)[lp] Transport [erm, lp] +r_3744 phosphatidylethanolamine (1-16:1, 2-18:1) transport, ER membrane-lipid particle phosphatidylethanolamine (1-16:1, 2-18:1)[erm] <=> phosphatidylethanolamine (1-16:1, 2-18:1)[lp] Transport [erm, lp] +r_3745 phosphatidylethanolamine (1-18:0, 2-18:1) transport, ER membrane-lipid particle phosphatidylethanolamine (1-18:0, 2-18:1)[erm] <=> phosphatidylethanolamine (1-18:0, 2-18:1)[lp] Transport [erm, lp] +r_3746 phosphatidylethanolamine (1-18:1, 2-18:1) transport, ER membrane-lipid particle phosphatidylethanolamine (1-18:1, 2-18:1)[erm] <=> phosphatidylethanolamine (1-18:1, 2-18:1)[lp] Transport [erm, lp] +r_3747 1-acylglycerophosphocholine (16:0) transport, ER membrane-lipid particle 1-acylglycerophosphocholine (16:0)[erm] <=> 1-acylglycerophosphocholine (16:0)[lp] Transport [erm, lp] +r_3748 1-acylglycerophosphocholine (16:1) transport, ER membrane-lipid particle 1-acylglycerophosphocholine (16:1)[erm] <=> 1-acylglycerophosphocholine (16:1)[lp] Transport [erm, lp] +r_3749 1-acylglycerophosphocholine (18:0) transport, ER membrane-lipid particle 1-acylglycerophosphocholine (18:0)[erm] <=> 1-acylglycerophosphocholine (18:0)[lp] Transport [erm, lp] +r_3750 1-acylglycerophosphocholine (18:1) transport, ER membrane-lipid particle 1-acylglycerophosphocholine (18:1)[erm] <=> 1-acylglycerophosphocholine (18:1)[lp] Transport [erm, lp] +r_3751 1-acylglycerophosphoethanolamine (16:0) transport, ER membrane-lipid particle 1-acylglycerophosphoethanolamine (16:0)[erm] <=> 1-acylglycerophosphoethanolamine (16:0)[lp] Transport [erm, lp] +r_3752 1-acylglycerophosphoethanolamine (16:1) transport, ER membrane-lipid particle 1-acylglycerophosphoethanolamine (16:1)[erm] <=> 1-acylglycerophosphoethanolamine (16:1)[lp] Transport [erm, lp] +r_3753 1-acylglycerophosphoethanolamine (18:0) transport, ER membrane-lipid particle 1-acylglycerophosphoethanolamine (18:0)[erm] <=> 1-acylglycerophosphoethanolamine (18:0)[lp] Transport [erm, lp] +r_3754 1-acylglycerophosphoethanolamine (18:1) transport, ER membrane-lipid particle 1-acylglycerophosphoethanolamine (18:1)[erm] <=> 1-acylglycerophosphoethanolamine (18:1)[lp] Transport [erm, lp] +r_3755 phosphatidate (1-16:0, 2-18:1) transport, lipid particle-ER membrane phosphatidate (1-16:0, 2-18:1)[lp] <=> phosphatidate (1-16:0, 2-18:1)[erm] Transport [erm, lp] +r_3756 phosphatidate (1-16:1, 2-18:1) transport, lipid particle-ER membrane phosphatidate (1-16:1, 2-18:1)[lp] <=> phosphatidate (1-16:1, 2-18:1)[erm] Transport [erm, lp] +r_3757 phosphatidate (1-18:0, 2-18:1) transport, lipid particle-ER membrane phosphatidate (1-18:0, 2-18:1)[lp] <=> phosphatidate (1-18:0, 2-18:1)[erm] Transport [erm, lp] +r_3758 phosphatidate (1-18:1, 2-18:1) transport, lipid particle-ER membrane phosphatidate (1-18:1, 2-18:1)[lp] <=> phosphatidate (1-18:1, 2-18:1)[erm] Transport [erm, lp] +r_3759 phosphatidate (1-16:0, 2-16:1) transport, ER membrane-mitochondrial membrane phosphatidate (1-16:0, 2-16:1)[erm] <=> phosphatidate (1-16:0, 2-16:1)[mm] Transport [erm, mm] +r_3760 phosphatidate (1-16:1, 2-16:1) transport, ER membrane-mitochondrial membrane phosphatidate (1-16:1, 2-16:1)[erm] <=> phosphatidate (1-16:1, 2-16:1)[mm] Transport [erm, mm] +r_3761 phosphatidate (1-18:0, 2-16:1) transport, ER membrane-mitochondrial membrane phosphatidate (1-18:0, 2-16:1)[erm] <=> phosphatidate (1-18:0, 2-16:1)[mm] Transport [erm, mm] +r_3762 phosphatidate (1-18:1, 2-16:1) transport, ER membrane-mitochondrial membrane phosphatidate (1-18:1, 2-16:1)[erm] <=> phosphatidate (1-18:1, 2-16:1)[mm] Transport [erm, mm] +r_3763 phosphatidate (1-16:0, 2-18:1) transport, ER membrane-mitochondrial membrane phosphatidate (1-16:0, 2-18:1)[erm] <=> phosphatidate (1-16:0, 2-18:1)[mm] Transport [erm, mm] +r_3764 phosphatidate (1-16:1, 2-18:1) transport, ER membrane-mitochondrial membrane phosphatidate (1-16:1, 2-18:1)[erm] <=> phosphatidate (1-16:1, 2-18:1)[mm] Transport [erm, mm] +r_3765 phosphatidyl-L-serine (1-16:0, 2-16:1) transport, ER membrane-mitochondrial membrane phosphatidyl-L-serine (1-16:0, 2-16:1)[erm] <=> phosphatidyl-L-serine (1-16:0, 2-16:1)[mm] Transport [erm, mm] +r_3766 phosphatidyl-L-serine (1-16:1, 2-16:1) transport, ER membrane-mitochondrial membrane phosphatidyl-L-serine (1-16:1, 2-16:1)[erm] <=> phosphatidyl-L-serine (1-16:1, 2-16:1)[mm] Transport [erm, mm] +r_3767 phosphatidyl-L-serine (1-18:0, 2-16:1) transport, ER membrane-mitochondrial membrane phosphatidyl-L-serine (1-18:0, 2-16:1)[erm] <=> phosphatidyl-L-serine (1-18:0, 2-16:1)[mm] Transport [erm, mm] +r_3768 phosphatidyl-L-serine (1-18:1, 2-16:1) transport, ER membrane-mitochondrial membrane phosphatidyl-L-serine (1-18:1, 2-16:1)[erm] <=> phosphatidyl-L-serine (1-18:1, 2-16:1)[mm] Transport [erm, mm] +r_3769 phosphatidyl-L-serine (1-16:0, 2-18:1) transport, ER membrane-mitochondrial membrane phosphatidyl-L-serine (1-16:0, 2-18:1)[erm] <=> phosphatidyl-L-serine (1-16:0, 2-18:1)[mm] Transport [erm, mm] +r_3770 phosphatidyl-L-serine (1-16:1, 2-18:1) transport, ER membrane-mitochondrial membrane phosphatidyl-L-serine (1-16:1, 2-18:1)[erm] <=> phosphatidyl-L-serine (1-16:1, 2-18:1)[mm] Transport [erm, mm] +r_3771 phosphatidyl-L-serine (1-18:0, 2-18:1) transport, ER membrane-mitochondrial membrane phosphatidyl-L-serine (1-18:0, 2-18:1)[erm] <=> phosphatidyl-L-serine (1-18:0, 2-18:1)[mm] Transport [erm, mm] +r_3772 phosphatidyl-L-serine (1-18:1, 2-18:1) transport, ER membrane-mitochondrial membrane phosphatidyl-L-serine (1-18:1, 2-18:1)[erm] <=> phosphatidyl-L-serine (1-18:1, 2-18:1)[mm] Transport [erm, mm] +r_3773 phosphatidylethanolamine (1-16:0, 2-16:1) transport, mitochondrial membrane-ER membrane phosphatidylethanolamine (1-16:0, 2-16:1)[mm] <=> phosphatidylethanolamine (1-16:0, 2-16:1)[erm] Transport [erm, mm] +r_3774 phosphatidylethanolamine (1-16:1, 2-16:1) transport, mitochondrial membrane-ER membrane phosphatidylethanolamine (1-16:1, 2-16:1)[mm] <=> phosphatidylethanolamine (1-16:1, 2-16:1)[erm] Transport [erm, mm] +r_3775 phosphatidylethanolamine (1-18:0, 2-16:1) transport, mitochondrial membrane-ER membrane phosphatidylethanolamine (1-18:0, 2-16:1)[mm] <=> phosphatidylethanolamine (1-18:0, 2-16:1)[erm] Transport [erm, mm] +r_3776 phosphatidylethanolamine (1-18:1, 2-16:1) transport, mitochondrial membrane-ER membrane phosphatidylethanolamine (1-18:1, 2-16:1)[mm] <=> phosphatidylethanolamine (1-18:1, 2-16:1)[erm] Transport [erm, mm] +r_3777 phosphatidylethanolamine (1-16:0, 2-18:1) transport, mitochondrial membrane-ER membrane phosphatidylethanolamine (1-16:0, 2-18:1)[mm] <=> phosphatidylethanolamine (1-16:0, 2-18:1)[erm] Transport [erm, mm] +r_3778 phosphatidylethanolamine (1-16:1, 2-18:1) transport, mitochondrial membrane-ER membrane phosphatidylethanolamine (1-16:1, 2-18:1)[mm] <=> phosphatidylethanolamine (1-16:1, 2-18:1)[erm] Transport [erm, mm] +r_3779 phosphatidylethanolamine (1-18:0, 2-18:1) transport, mitochondrial membrane-ER membrane phosphatidylethanolamine (1-18:0, 2-18:1)[mm] <=> phosphatidylethanolamine (1-18:0, 2-18:1)[erm] Transport [erm, mm] +r_3780 phosphatidylethanolamine (1-18:1, 2-18:1) transport, mitochondrial membrane-ER membrane phosphatidylethanolamine (1-18:1, 2-18:1)[mm] <=> phosphatidylethanolamine (1-18:1, 2-18:1)[erm] Transport [erm, mm] +r_3781 phosphatidylcholine (1-16:0, 2-16:1) transport, ER membrane-mitochondrial membrane phosphatidylcholine (1-16:0, 2-16:1)[erm] <=> phosphatidylcholine (1-16:0, 2-16:1)[mm] Transport [erm, mm] +r_3782 phosphatidylcholine (1-16:1, 2-16:1) transport, ER membrane-mitochondrial membrane phosphatidylcholine (1-16:1, 2-16:1)[erm] <=> phosphatidylcholine (1-16:1, 2-16:1)[mm] Transport [erm, mm] +r_3783 phosphatidylcholine (1-18:0, 2-16:1) transport, ER membrane-mitochondrial membrane phosphatidylcholine (1-18:0, 2-16:1)[erm] <=> phosphatidylcholine (1-18:0, 2-16:1)[mm] Transport [erm, mm] +r_3784 phosphatidylcholine (1-18:1, 2-16:1) transport, ER membrane-mitochondrial membrane phosphatidylcholine (1-18:1, 2-16:1)[erm] <=> phosphatidylcholine (1-18:1, 2-16:1)[mm] Transport [erm, mm] +r_3785 phosphatidylcholine (1-16:0, 2-18:1) transport, ER membrane-mitochondrial membrane phosphatidylcholine (1-16:0, 2-18:1)[erm] <=> phosphatidylcholine (1-16:0, 2-18:1)[mm] Transport [erm, mm] +r_3786 phosphatidylcholine (1-16:1, 2-18:1) transport, ER membrane-mitochondrial membrane phosphatidylcholine (1-16:1, 2-18:1)[erm] <=> phosphatidylcholine (1-16:1, 2-18:1)[mm] Transport [erm, mm] +r_3787 phosphatidylcholine (1-18:0, 2-18:1) transport, ER membrane-mitochondrial membrane phosphatidylcholine (1-18:0, 2-18:1)[erm] <=> phosphatidylcholine (1-18:0, 2-18:1)[mm] Transport [erm, mm] +r_3788 phosphatidylcholine (1-18:1, 2-18:1) transport, ER membrane-mitochondrial membrane phosphatidylcholine (1-18:1, 2-18:1)[erm] <=> phosphatidylcholine (1-18:1, 2-18:1)[mm] Transport [erm, mm] +r_3789 diglyceride (1-16:0, 2-16:1) transport, ER membrane-Golgi membrane diglyceride (1-16:0, 2-16:1)[erm] <=> diglyceride (1-16:0, 2-16:1)[gm] Transport [erm, gm] +r_3790 diglyceride (1-16:1, 2-16:1) transport, ER membrane-Golgi membrane diglyceride (1-16:1, 2-16:1)[erm] <=> diglyceride (1-16:1, 2-16:1)[gm] Transport [erm, gm] +r_3791 diglyceride (1-18:0, 2-16:1) transport, ER membrane-Golgi membrane diglyceride (1-18:0, 2-16:1)[erm] <=> diglyceride (1-18:0, 2-16:1)[gm] Transport [erm, gm] +r_3792 diglyceride (1-18:1, 2-16:1) transport, ER membrane-Golgi membrane diglyceride (1-18:1, 2-16:1)[erm] <=> diglyceride (1-18:1, 2-16:1)[gm] Transport [erm, gm] +r_3793 diglyceride (1-16:0, 2-18:1) transport, ER membrane-Golgi membrane diglyceride (1-16:0, 2-18:1)[erm] <=> diglyceride (1-16:0, 2-18:1)[gm] Transport [erm, gm] +r_3794 diglyceride (1-16:1, 2-18:1) transport, ER membrane-Golgi membrane diglyceride (1-16:1, 2-18:1)[erm] <=> diglyceride (1-16:1, 2-18:1)[gm] Transport [erm, gm] +r_3795 diglyceride (1-18:0, 2-18:1) transport, ER membrane-Golgi membrane diglyceride (1-18:0, 2-18:1)[erm] <=> diglyceride (1-18:0, 2-18:1)[gm] Transport [erm, gm] +r_3796 diglyceride (1-18:1, 2-18:1) transport, ER membrane-Golgi membrane diglyceride (1-18:1, 2-18:1)[erm] <=> diglyceride (1-18:1, 2-18:1)[gm] Transport [erm, gm] +r_3797 phosphatidate (1-16:0, 2-16:1) transport, ER membrane-Golgi membrane phosphatidate (1-16:0, 2-16:1)[erm] <=> phosphatidate (1-16:0, 2-16:1)[gm] Transport [erm, gm] +r_3798 phosphatidate (1-16:1, 2-16:1) transport, ER membrane-Golgi membrane phosphatidate (1-16:1, 2-16:1)[erm] <=> phosphatidate (1-16:1, 2-16:1)[gm] Transport [erm, gm] +r_3799 phosphatidate (1-18:0, 2-16:1) transport, ER membrane-Golgi membrane phosphatidate (1-18:0, 2-16:1)[erm] <=> phosphatidate (1-18:0, 2-16:1)[gm] Transport [erm, gm] +r_3800 phosphatidate (1-18:1, 2-16:1) transport, ER membrane-Golgi membrane phosphatidate (1-18:1, 2-16:1)[erm] <=> phosphatidate (1-18:1, 2-16:1)[gm] Transport [erm, gm] +r_3801 phosphatidate (1-16:0, 2-18:1) transport, ER membrane-Golgi membrane phosphatidate (1-16:0, 2-18:1)[erm] <=> phosphatidate (1-16:0, 2-18:1)[gm] Transport [erm, gm] +r_3802 phosphatidate (1-16:1, 2-18:1) transport, ER membrane-Golgi membrane phosphatidate (1-16:1, 2-18:1)[erm] <=> phosphatidate (1-16:1, 2-18:1)[gm] Transport [erm, gm] +r_3803 phosphatidate (1-18:0, 2-18:1) transport, ER membrane-Golgi membrane phosphatidate (1-18:0, 2-18:1)[erm] <=> phosphatidate (1-18:0, 2-18:1)[gm] Transport [erm, gm] +r_3804 phosphatidate (1-18:1, 2-18:1) transport, ER membrane-Golgi membrane phosphatidate (1-18:1, 2-18:1)[erm] <=> phosphatidate (1-18:1, 2-18:1)[gm] Transport [erm, gm] +r_3805 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-16:1) transport, ER membrane-Golgi membrane 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-16:1)[erm] <=> 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-16:1)[gm] Transport [erm, gm] +r_3806 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-16:1) transport, ER membrane-Golgi membrane 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-16:1)[erm] <=> 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-16:1)[gm] Transport [erm, gm] +r_3807 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-16:1) transport, ER membrane-Golgi membrane 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-16:1)[erm] <=> 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-16:1)[gm] Transport [erm, gm] +r_3808 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-16:1) transport, ER membrane-Golgi membrane 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-16:1)[erm] <=> 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-16:1)[gm] Transport [erm, gm] +r_3809 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-18:1) transport, ER membrane-Golgi membrane 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-18:1)[erm] <=> 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-18:1)[gm] Transport [erm, gm] +r_3810 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-18:1) transport, ER membrane-Golgi membrane 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-18:1)[erm] <=> 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-18:1)[gm] Transport [erm, gm] +r_3811 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-18:1) transport, ER membrane-Golgi membrane 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-18:1)[erm] <=> 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-18:1)[gm] Transport [erm, gm] +r_3812 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-18:1) transport, ER membrane-Golgi membrane 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-18:1)[erm] <=> 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-18:1)[gm] Transport [erm, gm] +r_3813 phosphatidyl-L-serine (1-16:0, 2-16:1) transport, ER membrane-Golgi membrane phosphatidyl-L-serine (1-16:0, 2-16:1)[erm] <=> phosphatidyl-L-serine (1-16:0, 2-16:1)[gm] YIL048W or YMR162C Transport [erm, gm] +r_3814 phosphatidyl-L-serine (1-16:1, 2-16:1) transport, ER membrane-Golgi membrane phosphatidyl-L-serine (1-16:1, 2-16:1)[erm] <=> phosphatidyl-L-serine (1-16:1, 2-16:1)[gm] YIL048W or YMR162C Transport [erm, gm] +r_3815 phosphatidyl-L-serine (1-18:0, 2-16:1) transport, ER membrane-Golgi membrane phosphatidyl-L-serine (1-18:0, 2-16:1)[erm] <=> phosphatidyl-L-serine (1-18:0, 2-16:1)[gm] YIL048W or YMR162C Transport [erm, gm] +r_3816 phosphatidyl-L-serine (1-18:1, 2-16:1) transport, ER membrane-Golgi membrane phosphatidyl-L-serine (1-18:1, 2-16:1)[erm] <=> phosphatidyl-L-serine (1-18:1, 2-16:1)[gm] YIL048W or YMR162C Transport [erm, gm] +r_3817 phosphatidyl-L-serine (1-16:0, 2-18:1) transport, ER membrane-Golgi membrane phosphatidyl-L-serine (1-16:0, 2-18:1)[erm] <=> phosphatidyl-L-serine (1-16:0, 2-18:1)[gm] YIL048W or YMR162C Transport [erm, gm] +r_3818 phosphatidyl-L-serine (1-16:1, 2-18:1) transport, ER membrane-Golgi membrane phosphatidyl-L-serine (1-16:1, 2-18:1)[erm] <=> phosphatidyl-L-serine (1-16:1, 2-18:1)[gm] YIL048W or YMR162C Transport [erm, gm] +r_3819 phosphatidyl-L-serine (1-18:0, 2-18:1) transport, ER membrane-Golgi membrane phosphatidyl-L-serine (1-18:0, 2-18:1)[erm] <=> phosphatidyl-L-serine (1-18:0, 2-18:1)[gm] YIL048W or YMR162C Transport [erm, gm] +r_3820 phosphatidyl-L-serine (1-18:1, 2-18:1) transport, ER membrane-Golgi membrane phosphatidyl-L-serine (1-18:1, 2-18:1)[erm] <=> phosphatidyl-L-serine (1-18:1, 2-18:1)[gm] YIL048W or YMR162C Transport [erm, gm] +r_3821 phosphatidylethanolamine (1-16:0, 2-16:1) transport, Golgi membrane-ER membrane phosphatidylethanolamine (1-16:0, 2-16:1)[gm] <=> phosphatidylethanolamine (1-16:0, 2-16:1)[erm] YAL026C Transport [erm, gm] +r_3822 phosphatidylethanolamine (1-16:1, 2-16:1) transport, Golgi membrane-ER membrane phosphatidylethanolamine (1-16:1, 2-16:1)[gm] <=> phosphatidylethanolamine (1-16:1, 2-16:1)[erm] YAL026C Transport [erm, gm] +r_3823 phosphatidylethanolamine (1-18:0, 2-16:1) transport, Golgi membrane-ER membrane phosphatidylethanolamine (1-18:0, 2-16:1)[gm] <=> phosphatidylethanolamine (1-18:0, 2-16:1)[erm] YAL026C Transport [erm, gm] +r_3824 phosphatidylethanolamine (1-18:1, 2-16:1) transport, Golgi membrane-ER membrane phosphatidylethanolamine (1-18:1, 2-16:1)[gm] <=> phosphatidylethanolamine (1-18:1, 2-16:1)[erm] YAL026C Transport [erm, gm] +r_3825 phosphatidylethanolamine (1-16:0, 2-18:1) transport, Golgi membrane-ER membrane phosphatidylethanolamine (1-16:0, 2-18:1)[gm] <=> phosphatidylethanolamine (1-16:0, 2-18:1)[erm] YAL026C Transport [erm, gm] +r_3826 phosphatidylethanolamine (1-16:1, 2-18:1) transport, Golgi membrane-ER membrane phosphatidylethanolamine (1-16:1, 2-18:1)[gm] <=> phosphatidylethanolamine (1-16:1, 2-18:1)[erm] YAL026C Transport [erm, gm] +r_3827 phosphatidylethanolamine (1-18:0, 2-18:1) transport, Golgi membrane-ER membrane phosphatidylethanolamine (1-18:0, 2-18:1)[gm] <=> phosphatidylethanolamine (1-18:0, 2-18:1)[erm] YAL026C Transport [erm, gm] +r_3828 phosphatidylethanolamine (1-18:1, 2-18:1) transport, Golgi membrane-ER membrane phosphatidylethanolamine (1-18:1, 2-18:1)[gm] <=> phosphatidylethanolamine (1-18:1, 2-18:1)[erm] YAL026C Transport [erm, gm] +r_3829 phosphatidate (1-16:0, 2-16:1) transport, ER membrane-vacuolar membrane phosphatidate (1-16:0, 2-16:1)[erm] <=> phosphatidate (1-16:0, 2-16:1)[vm] Transport [erm, vm] +r_3830 phosphatidate (1-16:1, 2-16:1) transport, ER membrane-vacuolar membrane phosphatidate (1-16:1, 2-16:1)[erm] <=> phosphatidate (1-16:1, 2-16:1)[vm] Transport [erm, vm] +r_3831 phosphatidate (1-18:0, 2-16:1) transport, ER membrane-vacuolar membrane phosphatidate (1-18:0, 2-16:1)[erm] <=> phosphatidate (1-18:0, 2-16:1)[vm] Transport [erm, vm] +r_3832 phosphatidate (1-18:1, 2-16:1) transport, ER membrane-vacuolar membrane phosphatidate (1-18:1, 2-16:1)[erm] <=> phosphatidate (1-18:1, 2-16:1)[vm] Transport [erm, vm] +r_3833 phosphatidate (1-16:0, 2-18:1) transport, ER membrane-vacuolar membrane phosphatidate (1-16:0, 2-18:1)[erm] <=> phosphatidate (1-16:0, 2-18:1)[vm] Transport [erm, vm] +r_3834 phosphatidate (1-16:1, 2-18:1) transport, ER membrane-vacuolar membrane phosphatidate (1-16:1, 2-18:1)[erm] <=> phosphatidate (1-16:1, 2-18:1)[vm] Transport [erm, vm] +r_3835 phosphatidate (1-18:0, 2-18:1) transport, ER membrane-vacuolar membrane phosphatidate (1-18:0, 2-18:1)[erm] <=> phosphatidate (1-18:0, 2-18:1)[vm] Transport [erm, vm] +r_3836 phosphatidate (1-18:1, 2-18:1) transport, ER membrane-vacuolar membrane phosphatidate (1-18:1, 2-18:1)[erm] <=> phosphatidate (1-18:1, 2-18:1)[vm] Transport [erm, vm] +r_3837 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-16:1) transport, ER membrane-vacuolar membrane 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-16:1)[erm] <=> 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-16:1)[vm] Transport [erm, vm] +r_3838 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-16:1) transport, ER membrane-vacuolar membrane 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-16:1)[erm] <=> 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-16:1)[vm] Transport [erm, vm] +r_3839 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-16:1) transport, ER membrane-vacuolar membrane 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-16:1)[erm] <=> 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-16:1)[vm] Transport [erm, vm] +r_3840 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-16:1) transport, ER membrane-vacuolar membrane 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-16:1)[erm] <=> 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-16:1)[vm] Transport [erm, vm] +r_3841 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-18:1) transport, ER membrane-vacuolar membrane 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-18:1)[erm] <=> 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-18:1)[vm] Transport [erm, vm] +r_3842 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-18:1) transport, ER membrane-vacuolar membrane 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-18:1)[erm] <=> 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-18:1)[vm] Transport [erm, vm] +r_3843 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-18:1) transport, ER membrane-vacuolar membrane 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-18:1)[erm] <=> 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-18:1)[vm] Transport [erm, vm] +r_3844 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-18:1) transport, ER membrane-vacuolar membrane 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-18:1)[erm] <=> 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-18:1)[vm] Transport [erm, vm] +r_3845 phosphatidyl-L-serine (1-16:0, 2-16:1) transport, ER membrane-vacuolar membrane phosphatidyl-L-serine (1-16:0, 2-16:1)[erm] <=> phosphatidyl-L-serine (1-16:0, 2-16:1)[vm] Transport [erm, vm] +r_3846 phosphatidyl-L-serine (1-16:1, 2-16:1) transport, ER membrane-vacuolar membrane phosphatidyl-L-serine (1-16:1, 2-16:1)[erm] <=> phosphatidyl-L-serine (1-16:1, 2-16:1)[vm] Transport [erm, vm] +r_3847 phosphatidyl-L-serine (1-18:0, 2-16:1) transport, ER membrane-vacuolar membrane phosphatidyl-L-serine (1-18:0, 2-16:1)[erm] <=> phosphatidyl-L-serine (1-18:0, 2-16:1)[vm] Transport [erm, vm] +r_3848 phosphatidyl-L-serine (1-18:1, 2-16:1) transport, ER membrane-vacuolar membrane phosphatidyl-L-serine (1-18:1, 2-16:1)[erm] <=> phosphatidyl-L-serine (1-18:1, 2-16:1)[vm] Transport [erm, vm] +r_3849 phosphatidyl-L-serine (1-16:0, 2-18:1) transport, ER membrane-vacuolar membrane phosphatidyl-L-serine (1-16:0, 2-18:1)[erm] <=> phosphatidyl-L-serine (1-16:0, 2-18:1)[vm] Transport [erm, vm] +r_3850 phosphatidyl-L-serine (1-16:1, 2-18:1) transport, ER membrane-vacuolar membrane phosphatidyl-L-serine (1-16:1, 2-18:1)[erm] <=> phosphatidyl-L-serine (1-16:1, 2-18:1)[vm] Transport [erm, vm] +r_3851 phosphatidyl-L-serine (1-18:0, 2-18:1) transport, ER membrane-vacuolar membrane phosphatidyl-L-serine (1-18:0, 2-18:1)[erm] <=> phosphatidyl-L-serine (1-18:0, 2-18:1)[vm] Transport [erm, vm] +r_3852 phosphatidyl-L-serine (1-18:1, 2-18:1) transport, ER membrane-vacuolar membrane phosphatidyl-L-serine (1-18:1, 2-18:1)[erm] <=> phosphatidyl-L-serine (1-18:1, 2-18:1)[vm] Transport [erm, vm] +r_3853 phosphatidylethanolamine (1-16:0, 2-16:1) transport, vacuolar membrane-ER membrane phosphatidylethanolamine (1-16:0, 2-16:1)[vm] <=> phosphatidylethanolamine (1-16:0, 2-16:1)[erm] Transport [erm, vm] +r_3854 phosphatidylethanolamine (1-16:1, 2-16:1) transport, vacuolar membrane-ER membrane phosphatidylethanolamine (1-16:1, 2-16:1)[vm] <=> phosphatidylethanolamine (1-16:1, 2-16:1)[erm] Transport [erm, vm] +r_3855 phosphatidylethanolamine (1-18:0, 2-16:1) transport, vacuolar membrane-ER membrane phosphatidylethanolamine (1-18:0, 2-16:1)[vm] <=> phosphatidylethanolamine (1-18:0, 2-16:1)[erm] Transport [erm, vm] +r_3856 phosphatidylethanolamine (1-18:1, 2-16:1) transport, vacuolar membrane-ER membrane phosphatidylethanolamine (1-18:1, 2-16:1)[vm] <=> phosphatidylethanolamine (1-18:1, 2-16:1)[erm] Transport [erm, vm] +r_3857 phosphatidylethanolamine (1-16:0, 2-18:1) transport, vacuolar membrane-ER membrane phosphatidylethanolamine (1-16:0, 2-18:1)[vm] <=> phosphatidylethanolamine (1-16:0, 2-18:1)[erm] Transport [erm, vm] +r_3858 phosphatidylethanolamine (1-16:1, 2-18:1) transport, vacuolar membrane-ER membrane phosphatidylethanolamine (1-16:1, 2-18:1)[vm] <=> phosphatidylethanolamine (1-16:1, 2-18:1)[erm] Transport [erm, vm] +r_3859 phosphatidylethanolamine (1-18:0, 2-18:1) transport, vacuolar membrane-ER membrane phosphatidylethanolamine (1-18:0, 2-18:1)[vm] <=> phosphatidylethanolamine (1-18:0, 2-18:1)[erm] Transport [erm, vm] +r_3860 phosphatidylethanolamine (1-18:1, 2-18:1) transport, vacuolar membrane-ER membrane phosphatidylethanolamine (1-18:1, 2-18:1)[vm] <=> phosphatidylethanolamine (1-18:1, 2-18:1)[erm] Transport [erm, vm] +r_3861 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-16:0, 2-16:1) transport, vacuolar membrane-ER membrane 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-16:0, 2-16:1)[vm] <=> 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-16:0, 2-16:1)[erm] Transport [erm, vm] +r_3862 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-16:1, 2-16:1) transport, vacuolar membrane-ER membrane 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-16:1, 2-16:1)[vm] <=> 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-16:1, 2-16:1)[erm] Transport [erm, vm] +r_3863 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-18:0, 2-16:1) transport, vacuolar membrane-ER membrane 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-18:0, 2-16:1)[vm] <=> 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-18:0, 2-16:1)[erm] Transport [erm, vm] +r_3864 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-18:1, 2-16:1) transport, vacuolar membrane-ER membrane 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-18:1, 2-16:1)[vm] <=> 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-18:1, 2-16:1)[erm] Transport [erm, vm] +r_3865 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-16:0, 2-18:1) transport, vacuolar membrane-ER membrane 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-16:0, 2-18:1)[vm] <=> 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-16:0, 2-18:1)[erm] Transport [erm, vm] +r_3866 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-16:1, 2-18:1) transport, vacuolar membrane-ER membrane 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-16:1, 2-18:1)[vm] <=> 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-16:1, 2-18:1)[erm] Transport [erm, vm] +r_3867 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-18:0, 2-18:1) transport, vacuolar membrane-ER membrane 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-18:0, 2-18:1)[vm] <=> 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-18:0, 2-18:1)[erm] Transport [erm, vm] +r_3868 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-18:1, 2-18:1) transport, vacuolar membrane-ER membrane 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-18:1, 2-18:1)[vm] <=> 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-18:1, 2-18:1)[erm] Transport [erm, vm] +r_3869 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-16:1) transport, ER membrane-cell envelope 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-16:1)[erm] <=> 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-16:1)[ce] Transport [ce, erm] +r_3870 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-16:1) transport, ER membrane-cell envelope 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-16:1)[erm] <=> 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-16:1)[ce] Transport [ce, erm] +r_3871 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-16:1) transport, ER membrane-cell envelope 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-16:1)[erm] <=> 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-16:1)[ce] Transport [ce, erm] +r_3872 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-16:1) transport, ER membrane-cell envelope 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-16:1)[erm] <=> 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-16:1)[ce] Transport [ce, erm] +r_3873 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-18:1) transport, ER membrane-cell envelope 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-18:1)[erm] <=> 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-18:1)[ce] Transport [ce, erm] +r_3874 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-18:1) transport, ER membrane-cell envelope 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-18:1)[erm] <=> 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-18:1)[ce] Transport [ce, erm] +r_3875 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-18:1) transport, ER membrane-cell envelope 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-18:1)[erm] <=> 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-18:1)[ce] Transport [ce, erm] +r_3876 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-18:1) transport, ER membrane-cell envelope 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-18:1)[erm] <=> 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-18:1)[ce] Transport [ce, erm] +r_3877 phosphatidylcholine (1-16:0, 2-16:1) transport, ER membrane-cell envelope phosphatidylcholine (1-16:0, 2-16:1)[erm] <=> phosphatidylcholine (1-16:0, 2-16:1)[ce] Transport [ce, erm] +r_3878 phosphatidylcholine (1-16:1, 2-16:1) transport, ER membrane-cell envelope phosphatidylcholine (1-16:1, 2-16:1)[erm] <=> phosphatidylcholine (1-16:1, 2-16:1)[ce] Transport [ce, erm] +r_3879 phosphatidylcholine (1-18:0, 2-16:1) transport, ER membrane-cell envelope phosphatidylcholine (1-18:0, 2-16:1)[erm] <=> phosphatidylcholine (1-18:0, 2-16:1)[ce] Transport [ce, erm] +r_3880 phosphatidylcholine (1-18:1, 2-16:1) transport, ER membrane-cell envelope phosphatidylcholine (1-18:1, 2-16:1)[erm] <=> phosphatidylcholine (1-18:1, 2-16:1)[ce] Transport [ce, erm] +r_3881 phosphatidylcholine (1-16:0, 2-18:1) transport, ER membrane-cell envelope phosphatidylcholine (1-16:0, 2-18:1)[erm] <=> phosphatidylcholine (1-16:0, 2-18:1)[ce] Transport [ce, erm] +r_3882 phosphatidylcholine (1-16:1, 2-18:1) transport, ER membrane-cell envelope phosphatidylcholine (1-16:1, 2-18:1)[erm] <=> phosphatidylcholine (1-16:1, 2-18:1)[ce] Transport [ce, erm] +r_3883 phosphatidylcholine (1-18:0, 2-18:1) transport, ER membrane-cell envelope phosphatidylcholine (1-18:0, 2-18:1)[erm] <=> phosphatidylcholine (1-18:0, 2-18:1)[ce] Transport [ce, erm] +r_3884 phosphatidylcholine (1-18:1, 2-18:1) transport, ER membrane-cell envelope phosphatidylcholine (1-18:1, 2-18:1)[erm] <=> phosphatidylcholine (1-18:1, 2-18:1)[ce] Transport [ce, erm] +r_3885 phosphatidylethanolamine (1-16:0, 2-16:1) transport, ER membrane-cell envelope phosphatidylethanolamine (1-16:0, 2-16:1)[erm] <=> phosphatidylethanolamine (1-16:0, 2-16:1)[ce] YAL026C Transport [ce, erm] +r_3886 phosphatidylethanolamine (1-16:1, 2-16:1) transport, ER membrane-cell envelope phosphatidylethanolamine (1-16:1, 2-16:1)[erm] <=> phosphatidylethanolamine (1-16:1, 2-16:1)[ce] YAL026C Transport [ce, erm] +r_3887 phosphatidylethanolamine (1-18:0, 2-16:1) transport, ER membrane-cell envelope phosphatidylethanolamine (1-18:0, 2-16:1)[erm] <=> phosphatidylethanolamine (1-18:0, 2-16:1)[ce] YAL026C Transport [ce, erm] +r_3888 phosphatidylethanolamine (1-18:1, 2-16:1) transport, ER membrane-cell envelope phosphatidylethanolamine (1-18:1, 2-16:1)[erm] <=> phosphatidylethanolamine (1-18:1, 2-16:1)[ce] YAL026C Transport [ce, erm] +r_3889 phosphatidylethanolamine (1-16:0, 2-18:1) transport, ER membrane-cell envelope phosphatidylethanolamine (1-16:0, 2-18:1)[erm] <=> phosphatidylethanolamine (1-16:0, 2-18:1)[ce] YAL026C Transport [ce, erm] +r_3890 phosphatidylethanolamine (1-16:1, 2-18:1) transport, ER membrane-cell envelope phosphatidylethanolamine (1-16:1, 2-18:1)[erm] <=> phosphatidylethanolamine (1-16:1, 2-18:1)[ce] YAL026C Transport [ce, erm] +r_3891 phosphatidylethanolamine (1-18:0, 2-18:1) transport, ER membrane-cell envelope phosphatidylethanolamine (1-18:0, 2-18:1)[erm] <=> phosphatidylethanolamine (1-18:0, 2-18:1)[ce] YAL026C Transport [ce, erm] +r_3892 phosphatidylethanolamine (1-18:1, 2-18:1) transport, ER membrane-cell envelope phosphatidylethanolamine (1-18:1, 2-18:1)[erm] <=> phosphatidylethanolamine (1-18:1, 2-18:1)[ce] YAL026C Transport [ce, erm] +r_3893 phosphatidyl-L-serine (1-16:0, 2-16:1) transport, ER membrane-cell envelope phosphatidyl-L-serine (1-16:0, 2-16:1)[erm] <=> phosphatidyl-L-serine (1-16:0, 2-16:1)[ce] YIL048W Transport [ce, erm] +r_3894 phosphatidyl-L-serine (1-16:1, 2-16:1) transport, ER membrane-cell envelope phosphatidyl-L-serine (1-16:1, 2-16:1)[erm] <=> phosphatidyl-L-serine (1-16:1, 2-16:1)[ce] YIL048W Transport [ce, erm] +r_3895 phosphatidyl-L-serine (1-18:0, 2-16:1) transport, ER membrane-cell envelope phosphatidyl-L-serine (1-18:0, 2-16:1)[erm] <=> phosphatidyl-L-serine (1-18:0, 2-16:1)[ce] YIL048W Transport [ce, erm] +r_3896 phosphatidyl-L-serine (1-18:1, 2-16:1) transport, ER membrane-cell envelope phosphatidyl-L-serine (1-18:1, 2-16:1)[erm] <=> phosphatidyl-L-serine (1-18:1, 2-16:1)[ce] YIL048W Transport [ce, erm] +r_3897 phosphatidyl-L-serine (1-16:0, 2-18:1) transport, ER membrane-cell envelope phosphatidyl-L-serine (1-16:0, 2-18:1)[erm] <=> phosphatidyl-L-serine (1-16:0, 2-18:1)[ce] YIL048W Transport [ce, erm] +r_3898 phosphatidyl-L-serine (1-16:1, 2-18:1) transport, ER membrane-cell envelope phosphatidyl-L-serine (1-16:1, 2-18:1)[erm] <=> phosphatidyl-L-serine (1-16:1, 2-18:1)[ce] YIL048W Transport [ce, erm] +r_3899 phosphatidyl-L-serine (1-18:0, 2-18:1) transport, ER membrane-cell envelope phosphatidyl-L-serine (1-18:0, 2-18:1)[erm] <=> phosphatidyl-L-serine (1-18:0, 2-18:1)[ce] YIL048W Transport [ce, erm] +r_3900 phosphatidyl-L-serine (1-18:1, 2-18:1) transport, ER membrane-cell envelope phosphatidyl-L-serine (1-18:1, 2-18:1)[erm] <=> phosphatidyl-L-serine (1-18:1, 2-18:1)[ce] YIL048W Transport [ce, erm] +r_3901 lignoceric acid transport, cell envelope-ER membrane lignoceric acid[ce] <=> lignoceric acid[erm] Transport [ce, erm] +r_3902 cerotic acid transport, cell envelope-ER membrane cerotic acid[ce] <=> cerotic acid[erm] Transport [ce, erm] +r_3903 phosphatidate (1-16:0, 2-16:1) transport, cell envelope-ER membrane phosphatidate (1-16:0, 2-16:1)[ce] <=> phosphatidate (1-16:0, 2-16:1)[erm] Transport [ce, erm] +r_3904 phosphatidate (1-16:1, 2-16:1) transport, cell envelope-ER membrane phosphatidate (1-16:1, 2-16:1)[ce] <=> phosphatidate (1-16:1, 2-16:1)[erm] Transport [ce, erm] +r_3905 phosphatidate (1-18:0, 2-16:1) transport, cell envelope-ER membrane phosphatidate (1-18:0, 2-16:1)[ce] <=> phosphatidate (1-18:0, 2-16:1)[erm] Transport [ce, erm] +r_3906 phosphatidate (1-18:1, 2-16:1) transport, cell envelope-ER membrane phosphatidate (1-18:1, 2-16:1)[ce] <=> phosphatidate (1-18:1, 2-16:1)[erm] Transport [ce, erm] +r_3907 phosphatidate (1-16:0, 2-18:1) transport, cell envelope-ER membrane phosphatidate (1-16:0, 2-18:1)[ce] <=> phosphatidate (1-16:0, 2-18:1)[erm] Transport [ce, erm] +r_3908 phosphatidate (1-16:1, 2-18:1) transport, cell envelope-ER membrane phosphatidate (1-16:1, 2-18:1)[ce] <=> phosphatidate (1-16:1, 2-18:1)[erm] Transport [ce, erm] +r_3909 phosphatidate (1-18:0, 2-18:1) transport, cell envelope-ER membrane phosphatidate (1-18:0, 2-18:1)[ce] <=> phosphatidate (1-18:0, 2-18:1)[erm] Transport [ce, erm] +r_3910 phosphatidate (1-18:1, 2-18:1) transport, cell envelope-ER membrane phosphatidate (1-18:1, 2-18:1)[ce] <=> phosphatidate (1-18:1, 2-18:1)[erm] Transport [ce, erm] +r_3911 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-16:0, 2-16:1) transport, cell envelope-ER membrane 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-16:0, 2-16:1)[ce] <=> 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-16:0, 2-16:1)[erm] Transport [ce, erm] +r_3912 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-16:1, 2-16:1) transport, cell envelope-ER membrane 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-16:1, 2-16:1)[ce] <=> 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-16:1, 2-16:1)[erm] Transport [ce, erm] +r_3913 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-18:0, 2-16:1) transport, cell envelope-ER membrane 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-18:0, 2-16:1)[ce] <=> 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-18:0, 2-16:1)[erm] Transport [ce, erm] +r_3914 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-18:1, 2-16:1) transport, cell envelope-ER membrane 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-18:1, 2-16:1)[ce] <=> 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-18:1, 2-16:1)[erm] Transport [ce, erm] +r_3915 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-16:0, 2-18:1) transport, cell envelope-ER membrane 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-16:0, 2-18:1)[ce] <=> 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-16:0, 2-18:1)[erm] Transport [ce, erm] +r_3916 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-16:1, 2-18:1) transport, cell envelope-ER membrane 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-16:1, 2-18:1)[ce] <=> 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-16:1, 2-18:1)[erm] Transport [ce, erm] +r_3917 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-18:0, 2-18:1) transport, cell envelope-ER membrane 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-18:0, 2-18:1)[ce] <=> 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-18:0, 2-18:1)[erm] Transport [ce, erm] +r_3918 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-18:1, 2-18:1) transport, cell envelope-ER membrane 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-18:1, 2-18:1)[ce] <=> 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-18:1, 2-18:1)[erm] Transport [ce, erm] +r_3919 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-16:0, 2-16:1) transport, cell envelope-ER membrane 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-16:0, 2-16:1)[ce] <=> 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-16:0, 2-16:1)[erm] Transport [ce, erm] +r_3920 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-16:1, 2-16:1) transport, cell envelope-ER membrane 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-16:1, 2-16:1)[ce] <=> 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-16:1, 2-16:1)[erm] Transport [ce, erm] +r_3921 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-18:0, 2-16:1) transport, cell envelope-ER membrane 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-18:0, 2-16:1)[ce] <=> 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-18:0, 2-16:1)[erm] Transport [ce, erm] +r_3922 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-18:1, 2-16:1) transport, cell envelope-ER membrane 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-18:1, 2-16:1)[ce] <=> 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-18:1, 2-16:1)[erm] Transport [ce, erm] +r_3923 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-16:0, 2-18:1) transport, cell envelope-ER membrane 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-16:0, 2-18:1)[ce] <=> 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-16:0, 2-18:1)[erm] Transport [ce, erm] +r_3924 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-16:1, 2-18:1) transport, cell envelope-ER membrane 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-16:1, 2-18:1)[ce] <=> 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-16:1, 2-18:1)[erm] Transport [ce, erm] +r_3925 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-18:0, 2-18:1) transport, cell envelope-ER membrane 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-18:0, 2-18:1)[ce] <=> 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-18:0, 2-18:1)[erm] Transport [ce, erm] +r_3926 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-18:1, 2-18:1) transport, cell envelope-ER membrane 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-18:1, 2-18:1)[ce] <=> 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-18:1, 2-18:1)[erm] Transport [ce, erm] +r_3927 zymosteryl palmitoleate transport, ER membrane-cell envelope zymosteryl palmitoleate[erm] <=> zymosteryl palmitoleate[ce] Transport [ce, erm] +r_3928 zymosteryl oleate transport, ER membrane-cell envelope zymosteryl oleate[erm] <=> zymosteryl oleate[ce] Transport [ce, erm] +r_3929 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-16:1) transport, ER membrane-nucleus 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-16:1)[erm] <=> 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-16:1)[n] Transport [erm, n] +r_3930 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-16:1) transport, ER membrane-nucleus 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-16:1)[erm] <=> 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-16:1)[n] Transport [erm, n] +r_3931 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-16:1) transport, ER membrane-nucleus 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-16:1)[erm] <=> 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-16:1)[n] Transport [erm, n] +r_3932 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-16:1) transport, ER membrane-nucleus 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-16:1)[erm] <=> 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-16:1)[n] Transport [erm, n] +r_3933 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-18:1) transport, ER membrane-nucleus 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-18:1)[erm] <=> 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-18:1)[n] Transport [erm, n] +r_3934 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-18:1) transport, ER membrane-nucleus 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-18:1)[erm] <=> 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-18:1)[n] Transport [erm, n] +r_3935 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-18:1) transport, ER membrane-nucleus 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-18:1)[erm] <=> 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-18:1)[n] Transport [erm, n] +r_3936 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-18:1) transport, ER membrane-nucleus 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-18:1)[erm] <=> 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-18:1)[n] Transport [erm, n] +r_3937 lignoceric acid transport, ER membrane-ER lignoceric acid[erm] <=> lignoceric acid[er] Transport [erm, er] +r_3938 cerotic acid transport, ER membrane-ER cerotic acid[erm] <=> cerotic acid[er] Transport [erm, er] +r_3939 ergosterol transport, ER-ER membrane ergosterol[er] <=> ergosterol[erm] Transport [erm, er] +r_3940 phosphate transport, ER-ER membrane phosphate[er] => phosphate[erm] Transport [erm, er] +r_3941 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-16:0, 2-16:1) transport, vacuolar membrane-Golgi membrane 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-16:0, 2-16:1)[vm] <=> 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-16:0, 2-16:1)[gm] Transport [vm, gm] +r_3942 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-16:1, 2-16:1) transport, vacuolar membrane-Golgi membrane 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-16:1, 2-16:1)[vm] <=> 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-16:1, 2-16:1)[gm] Transport [vm, gm] +r_3943 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-18:0, 2-16:1) transport, vacuolar membrane-Golgi membrane 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-18:0, 2-16:1)[vm] <=> 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-18:0, 2-16:1)[gm] Transport [vm, gm] +r_3944 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-18:1, 2-16:1) transport, vacuolar membrane-Golgi membrane 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-18:1, 2-16:1)[vm] <=> 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-18:1, 2-16:1)[gm] Transport [vm, gm] +r_3945 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-16:0, 2-18:1) transport, vacuolar membrane-Golgi membrane 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-16:0, 2-18:1)[vm] <=> 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-16:0, 2-18:1)[gm] Transport [vm, gm] +r_3946 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-16:1, 2-18:1) transport, vacuolar membrane-Golgi membrane 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-16:1, 2-18:1)[vm] <=> 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-16:1, 2-18:1)[gm] Transport [vm, gm] +r_3947 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-18:0, 2-18:1) transport, vacuolar membrane-Golgi membrane 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-18:0, 2-18:1)[vm] <=> 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-18:0, 2-18:1)[gm] Transport [vm, gm] +r_3948 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-18:1, 2-18:1) transport, vacuolar membrane-Golgi membrane 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-18:1, 2-18:1)[vm] <=> 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-18:1, 2-18:1)[gm] Transport [vm, gm] +r_3949 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-16:0, 2-16:1) transport, vacuolar membrane-cell envelope 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-16:0, 2-16:1)[vm] <=> 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-16:0, 2-16:1)[ce] Transport [vm, ce] +r_3950 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-16:1, 2-16:1) transport, vacuolar membrane-cell envelope 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-16:1, 2-16:1)[vm] <=> 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-16:1, 2-16:1)[ce] Transport [vm, ce] +r_3951 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-18:0, 2-16:1) transport, vacuolar membrane-cell envelope 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-18:0, 2-16:1)[vm] <=> 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-18:0, 2-16:1)[ce] Transport [vm, ce] +r_3952 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-18:1, 2-16:1) transport, vacuolar membrane-cell envelope 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-18:1, 2-16:1)[vm] <=> 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-18:1, 2-16:1)[ce] Transport [vm, ce] +r_3953 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-16:0, 2-18:1) transport, vacuolar membrane-cell envelope 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-16:0, 2-18:1)[vm] <=> 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-16:0, 2-18:1)[ce] Transport [vm, ce] +r_3954 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-16:1, 2-18:1) transport, vacuolar membrane-cell envelope 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-16:1, 2-18:1)[vm] <=> 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-16:1, 2-18:1)[ce] Transport [vm, ce] +r_3955 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-18:0, 2-18:1) transport, vacuolar membrane-cell envelope 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-18:0, 2-18:1)[vm] <=> 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-18:0, 2-18:1)[ce] Transport [vm, ce] +r_3956 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-18:1, 2-18:1) transport, vacuolar membrane-cell envelope 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-18:1, 2-18:1)[vm] <=> 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-18:1, 2-18:1)[ce] Transport [vm, ce] +r_3957 H+ transport, mitochondrion-mitochondrial membrane H+[m] <=> H+[mm] Transport [m, mm] +r_3958 glycerol 3-phosphate transport, mitochondrion-mitochondrial membrane glycerol 3-phosphate[m] <=> glycerol 3-phosphate[mm] Transport [m, mm] +r_3959 CMP transport, mitochondrion-mitochondrial membrane CMP[m] <=> CMP[mm] YBR192W Transport [m, mm] +r_3960 CTP transport, mitochondrion-mitochondrial membrane CTP[m] <=> CTP[mm] YBR192W Transport [m, mm] +r_3961 phosphate transport, mitochondrion-mitochondrial membrane phosphate[m] <=> phosphate[mm] YER053C or YJR077C or YLR348C Transport [m, mm] +r_3962 diphosphate transport, mitochondrion-mitochondrial membrane diphosphate[m] <=> diphosphate[mm] Transport [m, mm] +r_3963 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-16:1) [cytoplasm] SLIME rxn 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-16:1)[c] => 0.80903 1-phosphatidyl-1D-myo-inositol backbone[c] + 0.25643 C16:0 chain[c] + 0.25441 C16:1 chain[c] SLIME reaction +r_3964 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-16:1) [cytoplasm] SLIME rxn 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-16:1)[c] => 0.80701 1-phosphatidyl-1D-myo-inositol backbone[c] + 0.50883 C16:1 chain[c] SLIME reaction +r_3965 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-16:1) [cytoplasm] SLIME rxn 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-16:1)[c] => 0.83708 1-phosphatidyl-1D-myo-inositol backbone[c] + 0.25441 C16:1 chain[c] + 0.28448 C18:0 chain[c] SLIME reaction +r_3966 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-16:1) [cytoplasm] SLIME rxn 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-16:1)[c] => 0.83507 1-phosphatidyl-1D-myo-inositol backbone[c] + 0.25441 C16:1 chain[c] + 0.28247 C18:1 chain[c] SLIME reaction +r_3967 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-18:1) [cytoplasm] SLIME rxn 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-18:1)[c] => 0.83708 1-phosphatidyl-1D-myo-inositol backbone[c] + 0.25643 C16:0 chain[c] + 0.28247 C18:1 chain[c] SLIME reaction +r_3968 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-18:1) [cytoplasm] SLIME rxn 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-18:1)[c] => 0.83507 1-phosphatidyl-1D-myo-inositol backbone[c] + 0.25441 C16:1 chain[c] + 0.28247 C18:1 chain[c] SLIME reaction +r_3969 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-18:1) [cytoplasm] SLIME rxn 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-18:1)[c] => 0.86514 1-phosphatidyl-1D-myo-inositol backbone[c] + 0.28448 C18:0 chain[c] + 0.28247 C18:1 chain[c] SLIME reaction +r_3970 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-18:1) [cytoplasm] SLIME rxn 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-18:1)[c] => 0.86312 1-phosphatidyl-1D-myo-inositol backbone[c] + 0.56493 C18:1 chain[c] SLIME reaction +r_3971 ergosteryl palmitoleate [endoplasmic reticulum membrane] SLIME rxn ergosteryl palmitoleate[erm] => 0.63305 ergosterol ester backbone[erm] + 0.25441 C16:1 chain[c] SLIME reaction +r_3972 ergosteryl oleate [endoplasmic reticulum membrane] SLIME rxn ergosteryl oleate[erm] => 0.66111 ergosterol ester backbone[erm] + 0.28247 C18:1 chain[c] SLIME reaction +r_3973 ergosterol ester transport, ER membrane-cytoplasm ergosterol ester backbone[erm] <=> ergosterol ester backbone[c] Transport [c, erm] +r_3975 palmitate [cytoplasm] SLIME rxn palmitate[c] => 0.25542 fatty acid backbone[c] + 0.25643 C16:0 chain[c] SLIME reaction +r_3976 palmitoleate [cytoplasm] SLIME rxn palmitoleate[c] => 0.25341 fatty acid backbone[c] + 0.25441 C16:1 chain[c] SLIME reaction +r_3977 stearate [cytoplasm] SLIME rxn stearate[c] => 0.28347 fatty acid backbone[c] + 0.28448 C18:0 chain[c] SLIME reaction +r_3978 oleate [cytoplasm] SLIME rxn oleate[c] => 0.28146 fatty acid backbone[c] + 0.28247 C18:1 chain[c] SLIME reaction +r_3979 phosphatidyl-L-serine (1-16:0, 2-16:1) [endoplasmic reticulum membrane] SLIME rxn phosphatidyl-L-serine (1-16:0, 2-16:1)[erm] => 0.73396 phosphatidyl-L-serine backbone[erm] + 0.25643 C16:0 chain[c] + 0.25441 C16:1 chain[c] SLIME reaction +r_3980 phosphatidyl-L-serine (1-16:1, 2-16:1) [endoplasmic reticulum membrane] SLIME rxn phosphatidyl-L-serine (1-16:1, 2-16:1)[erm] => 0.73195 phosphatidyl-L-serine backbone[erm] + 0.50883 C16:1 chain[c] SLIME reaction +r_3981 phosphatidyl-L-serine (1-18:0, 2-16:1) [endoplasmic reticulum membrane] SLIME rxn phosphatidyl-L-serine (1-18:0, 2-16:1)[erm] => 0.76202 phosphatidyl-L-serine backbone[erm] + 0.25441 C16:1 chain[c] + 0.28448 C18:0 chain[c] SLIME reaction +r_3982 phosphatidyl-L-serine (1-18:1, 2-16:1) [endoplasmic reticulum membrane] SLIME rxn phosphatidyl-L-serine (1-18:1, 2-16:1)[erm] => 0.76 phosphatidyl-L-serine backbone[erm] + 0.25441 C16:1 chain[c] + 0.28247 C18:1 chain[c] SLIME reaction +r_3983 phosphatidyl-L-serine (1-16:0, 2-18:1) [endoplasmic reticulum membrane] SLIME rxn phosphatidyl-L-serine (1-16:0, 2-18:1)[erm] => 0.76202 phosphatidyl-L-serine backbone[erm] + 0.25643 C16:0 chain[c] + 0.28247 C18:1 chain[c] SLIME reaction +r_3984 phosphatidyl-L-serine (1-16:1, 2-18:1) [endoplasmic reticulum membrane] SLIME rxn phosphatidyl-L-serine (1-16:1, 2-18:1)[erm] => 0.76 phosphatidyl-L-serine backbone[erm] + 0.25441 C16:1 chain[c] + 0.28247 C18:1 chain[c] SLIME reaction +r_3985 phosphatidyl-L-serine (1-18:0, 2-18:1) [endoplasmic reticulum membrane] SLIME rxn phosphatidyl-L-serine (1-18:0, 2-18:1)[erm] => 0.79007 phosphatidyl-L-serine backbone[erm] + 0.28448 C18:0 chain[c] + 0.28247 C18:1 chain[c] SLIME reaction +r_3986 phosphatidyl-L-serine (1-18:1, 2-18:1) [endoplasmic reticulum membrane] SLIME rxn phosphatidyl-L-serine (1-18:1, 2-18:1)[erm] => 0.78806 phosphatidyl-L-serine backbone[erm] + 0.56493 C18:1 chain[c] SLIME reaction +r_3987 phosphatidyl-L-serine transport, ER membrane-cytoplasm phosphatidyl-L-serine backbone[erm] <=> phosphatidyl-L-serine backbone[c] Transport [c, erm] +r_3988 phosphatidylcholine (1-16:0, 2-16:1) [endoplasmic reticulum membrane] SLIME rxn phosphatidylcholine (1-16:0, 2-16:1)[erm] => 0.73204 phosphatidylcholine backbone[erm] + 0.25643 C16:0 chain[c] + 0.25441 C16:1 chain[c] SLIME reaction +r_3989 phosphatidylcholine (1-16:1, 2-16:1) [endoplasmic reticulum membrane] SLIME rxn phosphatidylcholine (1-16:1, 2-16:1)[erm] => 0.73002 phosphatidylcholine backbone[erm] + 0.50883 C16:1 chain[c] SLIME reaction +r_3990 phosphatidylcholine (1-18:0, 2-16:1) [endoplasmic reticulum membrane] SLIME rxn phosphatidylcholine (1-18:0, 2-16:1)[erm] => 0.74409 phosphatidylcholine backbone[erm] + 0.25441 C16:1 chain[c] + 0.28448 C18:0 chain[c] SLIME reaction +r_3991 phosphatidylcholine (1-18:1, 2-16:1) [endoplasmic reticulum membrane] SLIME rxn phosphatidylcholine (1-18:1, 2-16:1)[erm] => 0.74207 phosphatidylcholine backbone[erm] + 0.25441 C16:1 chain[c] + 0.28247 C18:1 chain[c] SLIME reaction +r_3992 phosphatidylcholine (1-16:0, 2-18:1) [endoplasmic reticulum membrane] SLIME rxn phosphatidylcholine (1-16:0, 2-18:1)[erm] => 0.76009 phosphatidylcholine backbone[erm] + 0.25643 C16:0 chain[c] + 0.28247 C18:1 chain[c] SLIME reaction +r_3993 phosphatidylcholine (1-16:1, 2-18:1) [endoplasmic reticulum membrane] SLIME rxn phosphatidylcholine (1-16:1, 2-18:1)[erm] => 0.75807 phosphatidylcholine backbone[erm] + 0.25441 C16:1 chain[c] + 0.28247 C18:1 chain[c] SLIME reaction +r_3994 phosphatidylcholine (1-18:0, 2-18:1) [endoplasmic reticulum membrane] SLIME rxn phosphatidylcholine (1-18:0, 2-18:1)[erm] => 0.77214 phosphatidylcholine backbone[erm] + 0.28448 C18:0 chain[c] + 0.28247 C18:1 chain[c] SLIME reaction +r_3995 phosphatidylcholine (1-18:1, 2-18:1) [endoplasmic reticulum membrane] SLIME rxn phosphatidylcholine (1-18:1, 2-18:1)[erm] => 0.77013 phosphatidylcholine backbone[erm] + 0.56493 C18:1 chain[c] SLIME reaction +r_3996 phosphatidylcholine transport, ER membrane-cytoplasm phosphatidylcholine backbone[erm] <=> phosphatidylcholine backbone[c] Transport [c, erm] +r_3997 phosphatidylethanolamine (1-16:0, 2-16:1) [endoplasmic reticulum membrane] SLIME rxn phosphatidylethanolamine (1-16:0, 2-16:1)[erm] => 0.68995 phosphatidylethanolamine backbone[erm] + 0.25643 C16:0 chain[c] + 0.25441 C16:1 chain[c] SLIME reaction +r_3998 phosphatidylethanolamine (1-16:1, 2-16:1) [endoplasmic reticulum membrane] SLIME rxn phosphatidylethanolamine (1-16:1, 2-16:1)[erm] => 0.68794 phosphatidylethanolamine backbone[erm] + 0.50883 C16:1 chain[c] SLIME reaction +r_3999 phosphatidylethanolamine (1-18:0, 2-16:1) [endoplasmic reticulum membrane] SLIME rxn phosphatidylethanolamine (1-18:0, 2-16:1)[erm] => 0.71801 phosphatidylethanolamine backbone[erm] + 0.25441 C16:1 chain[c] + 0.28448 C18:0 chain[c] SLIME reaction +r_4000 phosphatidylethanolamine (1-18:1, 2-16:1) [endoplasmic reticulum membrane] SLIME rxn phosphatidylethanolamine (1-18:1, 2-16:1)[erm] => 0.71599 phosphatidylethanolamine backbone[erm] + 0.25441 C16:1 chain[c] + 0.28247 C18:1 chain[c] SLIME reaction +r_4001 phosphatidylethanolamine (1-16:0, 2-18:1) [endoplasmic reticulum membrane] SLIME rxn phosphatidylethanolamine (1-16:0, 2-18:1)[erm] => 0.71801 phosphatidylethanolamine backbone[erm] + 0.25643 C16:0 chain[c] + 0.28247 C18:1 chain[c] SLIME reaction +r_4002 phosphatidylethanolamine (1-16:1, 2-18:1) [endoplasmic reticulum membrane] SLIME rxn phosphatidylethanolamine (1-16:1, 2-18:1)[erm] => 0.71599 phosphatidylethanolamine backbone[erm] + 0.25441 C16:1 chain[c] + 0.28247 C18:1 chain[c] SLIME reaction +r_4003 phosphatidylethanolamine (1-18:0, 2-18:1) [endoplasmic reticulum membrane] SLIME rxn phosphatidylethanolamine (1-18:0, 2-18:1)[erm] => 0.74606 phosphatidylethanolamine backbone[erm] + 0.28448 C18:0 chain[c] + 0.28247 C18:1 chain[c] SLIME reaction +r_4004 phosphatidylethanolamine (1-18:1, 2-18:1) [endoplasmic reticulum membrane] SLIME rxn phosphatidylethanolamine (1-18:1, 2-18:1)[erm] => 0.74405 phosphatidylethanolamine backbone[erm] + 0.56493 C18:1 chain[c] SLIME reaction +r_4005 phosphatidylethanolamine transport, ER membrane-cytoplasm phosphatidylethanolamine backbone[erm] <=> phosphatidylethanolamine backbone[c] Transport [c, erm] +r_4006 triglyceride (1-16:0, 2-16:1, 3-16:0) [endoplasmic reticulum membrane] SLIME rxn triglyceride (1-16:0, 2-16:1, 3-16:0)[erm] => 0.80532 triglyceride backbone[erm] + 0.51286 C16:0 chain[c] + 0.25441 C16:1 chain[c] SLIME reaction +r_4007 triglyceride (1-16:0, 2-18:1, 3-16:0) [endoplasmic reticulum membrane] SLIME rxn triglyceride (1-16:0, 2-18:1, 3-16:0)[erm] => 0.83337 triglyceride backbone[erm] + 0.51286 C16:0 chain[c] + 0.28247 C18:1 chain[c] SLIME reaction +r_4008 triglyceride (1-16:1, 2-16:1, 3-16:0) [endoplasmic reticulum membrane] SLIME rxn triglyceride (1-16:1, 2-16:1, 3-16:0)[erm] => 0.8033 triglyceride backbone[erm] + 0.25643 C16:0 chain[c] + 0.50883 C16:1 chain[c] SLIME reaction +r_4009 triglyceride (1-16:1, 2-18:1, 3-16:0) [endoplasmic reticulum membrane] SLIME rxn triglyceride (1-16:1, 2-18:1, 3-16:0)[erm] => 0.83136 triglyceride backbone[erm] + 0.25643 C16:0 chain[c] + 0.25441 C16:1 chain[c] + 0.28247 C18:1 chain[c] SLIME reaction +r_4010 triglyceride (1-18:0, 2-16:1, 3-16:0) [endoplasmic reticulum membrane] SLIME rxn triglyceride (1-18:0, 2-16:1, 3-16:0)[erm] => 0.83337 triglyceride backbone[erm] + 0.25643 C16:0 chain[c] + 0.25441 C16:1 chain[c] + 0.28448 C18:0 chain[c] SLIME reaction +r_4011 triglyceride (1-18:0, 2-18:1, 3-16:0) [endoplasmic reticulum membrane] SLIME rxn triglyceride (1-18:0, 2-18:1, 3-16:0)[erm] => 0.86143 triglyceride backbone[erm] + 0.25643 C16:0 chain[c] + 0.28448 C18:0 chain[c] + 0.28247 C18:1 chain[c] SLIME reaction +r_4012 triglyceride (1-18:1, 2-16:1, 3-16:0) [endoplasmic reticulum membrane] SLIME rxn triglyceride (1-18:1, 2-16:1, 3-16:0)[erm] => 0.83136 triglyceride backbone[erm] + 0.25643 C16:0 chain[c] + 0.25441 C16:1 chain[c] + 0.28247 C18:1 chain[c] SLIME reaction +r_4013 triglyceride (1-18:1, 2-18:1, 3-16:0) [endoplasmic reticulum membrane] SLIME rxn triglyceride (1-18:1, 2-18:1, 3-16:0)[erm] => 0.85941 triglyceride backbone[erm] + 0.25643 C16:0 chain[c] + 0.56493 C18:1 chain[c] SLIME reaction +r_4014 triglyceride (1-16:0, 2-16:1, 3-16:1) [endoplasmic reticulum membrane] SLIME rxn triglyceride (1-16:0, 2-16:1, 3-16:1)[erm] => 0.8033 triglyceride backbone[erm] + 0.25643 C16:0 chain[c] + 0.50883 C16:1 chain[c] SLIME reaction +r_4015 triglyceride (1-16:0, 2-18:1, 3-16:1) [endoplasmic reticulum membrane] SLIME rxn triglyceride (1-16:0, 2-18:1, 3-16:1)[erm] => 0.83136 triglyceride backbone[erm] + 0.25643 C16:0 chain[c] + 0.25441 C16:1 chain[c] + 0.28247 C18:1 chain[c] SLIME reaction +r_4016 triglyceride (1-16:1, 2-16:1, 3-16:1) [endoplasmic reticulum membrane] SLIME rxn triglyceride (1-16:1, 2-16:1, 3-16:1)[erm] => 0.80129 triglyceride backbone[erm] + 0.76324 C16:1 chain[c] SLIME reaction +r_4017 triglyceride (1-16:1, 2-18:1, 3-16:1) [endoplasmic reticulum membrane] SLIME rxn triglyceride (1-16:1, 2-18:1, 3-16:1)[erm] => 0.82934 triglyceride backbone[erm] + 0.50883 C16:1 chain[c] + 0.28247 C18:1 chain[c] SLIME reaction +r_4018 triglyceride (1-18:0, 2-16:1, 3-16:1) [endoplasmic reticulum membrane] SLIME rxn triglyceride (1-18:0, 2-16:1, 3-16:1)[erm] => 0.83136 triglyceride backbone[erm] + 0.50883 C16:1 chain[c] + 0.28448 C18:0 chain[c] SLIME reaction +r_4019 triglyceride (1-18:0, 2-18:1, 3-16:1) [endoplasmic reticulum membrane] SLIME rxn triglyceride (1-18:0, 2-18:1, 3-16:1)[erm] => 0.85941 triglyceride backbone[erm] + 0.25441 C16:1 chain[c] + 0.28448 C18:0 chain[c] + 0.28247 C18:1 chain[c] SLIME reaction +r_4020 triglyceride (1-18:1, 2-16:1, 3-16:1) [endoplasmic reticulum membrane] SLIME rxn triglyceride (1-18:1, 2-16:1, 3-16:1)[erm] => 0.82934 triglyceride backbone[erm] + 0.50883 C16:1 chain[c] + 0.28247 C18:1 chain[c] SLIME reaction +r_4021 triglyceride (1-18:1, 2-18:1, 3-16:1) [endoplasmic reticulum membrane] SLIME rxn triglyceride (1-18:1, 2-18:1, 3-16:1)[erm] => 0.8574 triglyceride backbone[erm] + 0.25441 C16:1 chain[c] + 0.56493 C18:1 chain[c] SLIME reaction +r_4022 triglyceride (1-16:0, 2-16:1, 3-18:0) [endoplasmic reticulum membrane] SLIME rxn triglyceride (1-16:0, 2-16:1, 3-18:0)[erm] => 0.83337 triglyceride backbone[erm] + 0.25643 C16:0 chain[c] + 0.25441 C16:1 chain[c] + 0.28448 C18:0 chain[c] SLIME reaction +r_4023 triglyceride (1-16:0, 2-18:1, 3-18:0) [endoplasmic reticulum membrane] SLIME rxn triglyceride (1-16:0, 2-18:1, 3-18:0)[erm] => 0.86143 triglyceride backbone[erm] + 0.25643 C16:0 chain[c] + 0.28448 C18:0 chain[c] + 0.28247 C18:1 chain[c] SLIME reaction +r_4024 triglyceride (1-16:1, 2-16:1, 3-18:0) [endoplasmic reticulum membrane] SLIME rxn triglyceride (1-16:1, 2-16:1, 3-18:0)[erm] => 0.83136 triglyceride backbone[erm] + 0.50883 C16:1 chain[c] + 0.28448 C18:0 chain[c] SLIME reaction +r_4025 triglyceride (1-16:1, 2-18:1, 3-18:0) [endoplasmic reticulum membrane] SLIME rxn triglyceride (1-16:1, 2-18:1, 3-18:0)[erm] => 0.85941 triglyceride backbone[erm] + 0.25441 C16:1 chain[c] + 0.28448 C18:0 chain[c] + 0.28247 C18:1 chain[c] SLIME reaction +r_4026 triglyceride (1-18:0, 2-16:1, 3-18:0) [endoplasmic reticulum membrane] SLIME rxn triglyceride (1-18:0, 2-16:1, 3-18:0)[erm] => 0.86143 triglyceride backbone[erm] + 0.25441 C16:1 chain[c] + 0.56897 C18:0 chain[c] SLIME reaction +r_4027 triglyceride (1-18:0, 2-18:1, 3-18:0) [endoplasmic reticulum membrane] SLIME rxn triglyceride (1-18:0, 2-18:1, 3-18:0)[erm] => 0.88948 triglyceride backbone[erm] + 0.56897 C18:0 chain[c] + 0.28247 C18:1 chain[c] SLIME reaction +r_4028 triglyceride (1-18:1, 2-16:1, 3-18:0) [endoplasmic reticulum membrane] SLIME rxn triglyceride (1-18:1, 2-16:1, 3-18:0)[erm] => 0.85941 triglyceride backbone[erm] + 0.25441 C16:1 chain[c] + 0.28448 C18:0 chain[c] + 0.28247 C18:1 chain[c] SLIME reaction +r_4029 triglyceride (1-18:1, 2-18:1, 3-18:0) [endoplasmic reticulum membrane] SLIME rxn triglyceride (1-18:1, 2-18:1, 3-18:0)[erm] => 0.88747 triglyceride backbone[erm] + 0.28448 C18:0 chain[c] + 0.56493 C18:1 chain[c] SLIME reaction +r_4030 triglyceride (1-16:0, 2-16:1, 3-18:1) [endoplasmic reticulum membrane] SLIME rxn triglyceride (1-16:0, 2-16:1, 3-18:1)[erm] => 0.83136 triglyceride backbone[erm] + 0.25643 C16:0 chain[c] + 0.25441 C16:1 chain[c] + 0.28247 C18:1 chain[c] SLIME reaction +r_4031 triglyceride (1-16:0, 2-18:1, 3-18:1) [endoplasmic reticulum membrane] SLIME rxn triglyceride (1-16:0, 2-18:1, 3-18:1)[erm] => 0.85941 triglyceride backbone[erm] + 0.25643 C16:0 chain[c] + 0.56493 C18:1 chain[c] SLIME reaction +r_4032 triglyceride (1-16:1, 2-16:1, 3-18:1) [endoplasmic reticulum membrane] SLIME rxn triglyceride (1-16:1, 2-16:1, 3-18:1)[erm] => 0.82934 triglyceride backbone[erm] + 0.50883 C16:1 chain[c] + 0.28247 C18:1 chain[c] SLIME reaction +r_4033 triglyceride (1-16:1, 2-18:1, 3-18:1) [endoplasmic reticulum membrane] SLIME rxn triglyceride (1-16:1, 2-18:1, 3-18:1)[erm] => 0.8574 triglyceride backbone[erm] + 0.25441 C16:1 chain[c] + 0.56493 C18:1 chain[c] SLIME reaction +r_4034 triglyceride (1-18:0, 2-16:1, 3-18:1) [endoplasmic reticulum membrane] SLIME rxn triglyceride (1-18:0, 2-16:1, 3-18:1)[erm] => 0.85941 triglyceride backbone[erm] + 0.25441 C16:1 chain[c] + 0.28448 C18:0 chain[c] + 0.28247 C18:1 chain[c] SLIME reaction +r_4035 triglyceride (1-18:0, 2-18:1, 3-18:1) [endoplasmic reticulum membrane] SLIME rxn triglyceride (1-18:0, 2-18:1, 3-18:1)[erm] => 0.88747 triglyceride backbone[erm] + 0.28448 C18:0 chain[c] + 0.56493 C18:1 chain[c] SLIME reaction +r_4036 triglyceride (1-18:1, 2-16:1, 3-18:1) [endoplasmic reticulum membrane] SLIME rxn triglyceride (1-18:1, 2-16:1, 3-18:1)[erm] => 0.8574 triglyceride backbone[erm] + 0.25441 C16:1 chain[c] + 0.56493 C18:1 chain[c] SLIME reaction +r_4037 triglyceride (1-18:1, 2-18:1, 3-18:1) [endoplasmic reticulum membrane] SLIME rxn triglyceride (1-18:1, 2-18:1, 3-18:1)[erm] => 0.88545 triglyceride backbone[erm] + 0.8474 C18:1 chain[c] SLIME reaction +r_4038 triglyceride transport, ER membrane-cytoplasm triglyceride backbone[erm] <=> triglyceride backbone[c] Transport [c, erm] +r_4039 succinyl-CoA:acetate CoA transferase acetate[m] + succinyl-CoA[m] <=> acetyl-CoA[m] + succinate[m] YBL015W Pyruvate metabolism +r_4040 heme a transport heme a[m] <=> heme a[c] Transport [c, m] +r_4041 biomass pseudoreaction 55.3 ATP[c] + 55.3 H2O[c] + lipid[c] + protein[c] + carbohydrate[c] + RNA[c] + DNA[c] + cofactor[c] + ion[c] => 55.3 ADP[c] + biomass[c] + 55.3 H+[c] + 55.3 phosphate[c] Growth +r_4042 raffinose invertase H2O[e] + raffinose[e] => D-fructose[e] + melibiose[e] Histidine metabolism +r_4043 raffinose exchange raffinose[e] => Exchange reaction +r_4044 melibiose exchange melibiose[e] => Exchange reaction +r_4045 uridine hydrolase H2O[c] + uridine[c] => D-ribose[c] + uracil[c] YDR400W Pyrimidine metabolism +r_4046 non-growth associated maintenance reaction ATP[c] + H2O[c] => ADP[c] + H+[c] + phosphate[c] Growth non-growth associated maintenance +r_4047 protein pseudoreaction 0.52701 Ala-tRNA(Ala)[c] + 0.18459 Arg-tRNA(Arg)[c] + 0.11682 Asn-tRNA(Asn)[c] + 0.34173 Asp-tRNA(Asp)[c] + 0.0075813 Cys-tRNA(Cys)[c] + 0.12107 Gln-tRNA(Gln)[c] + 0.34667 Glu-tRNA(Glu)[c] + 0.33358 Gly-tRNA(Gly)[c] + 0.076157 His-tRNA(His)[c] + 0.22135 Ile-tRNA(Ile)[c] + 0.34047 Leu-tRNA(Leu)[c] + 0.32875 Lys-tRNA(Lys)[c] + 0.058238 Met-tRNA(Met)[c] + 0.15381 Phe-tRNA(Phe)[c] + 0.18919 Pro-tRNA(Pro)[c] + 0.21296 Ser-tRNA(Ser)[c] + 0.21986 Thr-tRNA(Thr)[c] + 0.032622 Trp-tRNA(Trp)[c] + 0.11716 Tyr-tRNA(Tyr)[c] + 0.30394 Val-tRNA(Val)[c] => 0.52701 tRNA(Ala)[c] + 0.18459 tRNA(Arg)[c] + 0.11682 tRNA(Asn)[c] + 0.34173 tRNA(Asp)[c] + 0.0075813 tRNA(Cys)[c] + 0.12107 tRNA(Gln)[c] + 0.34667 tRNA(Glu)[c] + 0.33358 tRNA(Gly)[c] + 0.076157 tRNA(His)[c] + 0.22135 tRNA(Ile)[c] + 0.34047 tRNA(Leu)[c] + 0.32875 tRNA(Lys)[c] + 0.058238 tRNA(Met)[c] + 0.15381 tRNA(Phe)[c] + 0.18919 tRNA(Pro)[c] + 0.21296 tRNA(Ser)[c] + 0.21986 tRNA(Thr)[c] + 0.032622 tRNA(Trp)[c] + 0.11716 tRNA(Tyr)[c] + 0.30394 tRNA(Val)[c] + protein[c] Growth +r_4048 carbohydrate pseudoreaction 0.74851 (1->3)-beta-D-glucan[ce] + 0.25009 (1->6)-beta-D-glucan[ce] + 0.36141 glycogen[c] + 0.71094 mannan[c] + 0.13828 trehalose[c] => carbohydrate[c] Growth +r_4049 RNA pseudoreaction 0.044535 AMP[c] + 0.043276 CMP[c] + 0.044535 GMP[c] + 0.057992 UMP[c] => RNA[c] Growth +r_4050 DNA pseudoreaction 0.0036 dAMP[c] + 0.0024 dCMP[c] + 0.0024 dGMP[c] + 0.0036 dTMP[c] => DNA[c] Growth +r_4051 ceramide transport ceramide backbone[g] => ceramide backbone[c] Transport [c, g] +r_4052 inositol phosphomannosylinositol phosphoceramide transport inositol phosphomannosylinositol phosphoceramide backbone[g] => inositol phosphomannosylinositol phosphoceramide backbone[c] Transport [c, g] +r_4053 inositol-P-ceramide transport inositol-P-ceramide backbone[g] => inositol-P-ceramide backbone[c] Transport [c, g] +r_4054 mannosylinositol phosphorylceramide transport mannosylinositol phosphorylceramide backbone[g] => mannosylinositol phosphorylceramide backbone[c] Transport [c, g] +r_4055 long-chain base transport long-chain base backbone[er] => long-chain base backbone[c] Transport [c, er] +r_4056 long-chain base phosphate transport long-chain base phosphate backbone[er] => long-chain base phosphate backbone[c] Transport [c, er] +r_4057 phosphatidate transport phosphatidate backbone[erm] => phosphatidate backbone[c] Transport [c, erm] +r_4058 diglyceride transport diglyceride backbone[erm] => diglyceride backbone[c] Transport [c, erm] +r_4059 sn-2-acyl-1-lysophosphatidylinositol transport sn-2-acyl-1-lysophosphatidylinositol backbone[erm] => sn-2-acyl-1-lysophosphatidylinositol backbone[c] Transport [c, erm] +r_4060 phosphatidylglycerol transport phosphatidylglycerol backbone[mm] => phosphatidylglycerol backbone[c] Transport [c, mm] +r_4061 cardiolipin transport cardiolipin backbone[mm] => cardiolipin backbone[c] Transport [c, mm] +r_4062 lipid backbone exchange lipid backbone[c] => Exchange reaction +r_4063 lipid backbone pseudoreaction 0.0069103 1-phosphatidyl-1D-myo-inositol backbone[c] + 0.026583 ergosterol[c] + 0.0068058 ergosterol ester backbone[c] + 0.0014801 fatty acid backbone[c] + 0.0059508 phosphatidyl-L-serine backbone[c] + 0.025783 phosphatidylcholine backbone[c] + 0.0069293 phosphatidylethanolamine backbone[c] + 0.0068571 triglyceride backbone[c] => lipid backbone[c] SLIME reaction +r_4064 lipid chain exchange lipid chain[c] => Exchange reaction +r_4065 lipid chain pseudoreaction 0.0080858 C16:0 chain[c] + 0.02373 C16:1 chain[c] + 0.0022663 C18:0 chain[c] + 0.0087066 C18:1 chain[c] => lipid chain[c] SLIME reaction +r_4066 ceramide-1 (C24) [Golgi] SLIME rxn ceramide-1 (C24)[g] => 0.65214 ceramide backbone[g] + 0.28448 C18:0 chain[c] + 0.36864 C24:0 chain[c] SLIME reaction +r_4067 ceramide-1 (C26) [Golgi] SLIME rxn ceramide-1 (C26)[g] => 0.6802 ceramide backbone[g] + 0.28448 C18:0 chain[c] + 0.3967 C26:0 chain[c] SLIME reaction +r_4068 ceramide-2 (C24) [Golgi] SLIME rxn ceramide-2 (C24)[g] => 0.66814 ceramide backbone[g] + 0.28448 C18:0 chain[c] + 0.36864 C24:0 chain[c] SLIME reaction +r_4069 ceramide-2 (C26) [Golgi] SLIME rxn ceramide-2 (C26)[g] => 0.6962 ceramide backbone[g] + 0.28448 C18:0 chain[c] + 0.3967 C26:0 chain[c] SLIME reaction +r_4070 ceramide-2' (C24) [Golgi] SLIME rxn ceramide-2' (C24)[g] => 0.66814 ceramide backbone[g] + 0.28448 C18:0 chain[c] + 0.36864 C24:0 chain[c] SLIME reaction +r_4071 ceramide-2' (C26) [Golgi] SLIME rxn ceramide-2' (C26)[g] => 0.6962 ceramide backbone[g] + 0.28448 C18:0 chain[c] + 0.3967 C26:0 chain[c] SLIME reaction +r_4072 ceramide-3 (C24) [Golgi] SLIME rxn ceramide-3 (C24)[g] => 0.68414 ceramide backbone[g] + 0.28448 C18:0 chain[c] + 0.36864 C24:0 chain[c] SLIME reaction +r_4073 ceramide-3 (C26) [Golgi] SLIME rxn ceramide-3 (C26)[g] => 0.71219 ceramide backbone[g] + 0.28448 C18:0 chain[c] + 0.3967 C26:0 chain[c] SLIME reaction +r_4074 ceramide-4 (C24) [Golgi] SLIME rxn ceramide-4 (C24)[g] => 0.70014 ceramide backbone[g] + 0.28448 C18:0 chain[c] + 0.36864 C24:0 chain[c] SLIME reaction +r_4075 ceramide-4 (C26) [Golgi] SLIME rxn ceramide-4 (C26)[g] => 0.72819 ceramide backbone[g] + 0.28448 C18:0 chain[c] + 0.3967 C26:0 chain[c] SLIME reaction +r_4076 phytosphingosine [endoplasmic reticulum] SLIME rxn phytosphingosine[er] => 0.31751 long-chain base backbone[er] + 0.28448 C18:0 chain[c] SLIME reaction +r_4077 phytosphingosine 1-phosphate [endoplasmic reticulum] SLIME rxn phytosphingosine 1-phosphate[er] => 0.39749 long-chain base phosphate backbone[er] + 0.28448 C18:0 chain[c] SLIME reaction +r_4078 sphinganine [endoplasmic reticulum] SLIME rxn sphinganine[er] => 0.30252 long-chain base backbone[er] + 0.28448 C18:0 chain[c] SLIME reaction +r_4079 sphinganine 1-phosphate [endoplasmic reticulum] SLIME rxn sphinganine 1-phosphate[er] => 0.38049 long-chain base phosphate backbone[er] + 0.28448 C18:0 chain[c] SLIME reaction +r_4080 phosphatidate (1-16:0, 2-16:1) [endoplasmic reticulum membrane] SLIME rxn phosphatidate (1-16:0, 2-16:1)[erm] => 0.64487 phosphatidate backbone[erm] + 0.25643 C16:0 chain[c] + 0.25441 C16:1 chain[c] SLIME reaction +r_4081 phosphatidate (1-16:0, 2-18:1) [endoplasmic reticulum membrane] SLIME rxn phosphatidate (1-16:0, 2-18:1)[erm] => 0.67494 phosphatidate backbone[erm] + 0.25643 C16:0 chain[c] + 0.28247 C18:1 chain[c] SLIME reaction +r_4082 phosphatidate (1-16:1, 2-16:1) [endoplasmic reticulum membrane] SLIME rxn phosphatidate (1-16:1, 2-16:1)[erm] => 0.64487 phosphatidate backbone[erm] + 0.50883 C16:1 chain[c] SLIME reaction +r_4083 phosphatidate (1-16:1, 2-18:1) [endoplasmic reticulum membrane] SLIME rxn phosphatidate (1-16:1, 2-18:1)[erm] => 0.67292 phosphatidate backbone[erm] + 0.25441 C16:1 chain[c] + 0.28247 C18:1 chain[c] SLIME reaction +r_4084 phosphatidate (1-18:0, 2-16:1) [endoplasmic reticulum membrane] SLIME rxn phosphatidate (1-18:0, 2-16:1)[erm] => 0.67494 phosphatidate backbone[erm] + 0.25441 C16:1 chain[c] + 0.28448 C18:0 chain[c] SLIME reaction +r_4085 phosphatidate (1-18:0, 2-18:1) [endoplasmic reticulum membrane] SLIME rxn phosphatidate (1-18:0, 2-18:1)[erm] => 0.70299 phosphatidate backbone[erm] + 0.28448 C18:0 chain[c] + 0.28247 C18:1 chain[c] SLIME reaction +r_4086 phosphatidate (1-18:1, 2-16:1) [endoplasmic reticulum membrane] SLIME rxn phosphatidate (1-18:1, 2-16:1)[erm] => 0.67292 phosphatidate backbone[erm] + 0.25441 C16:1 chain[c] + 0.28247 C18:1 chain[c] SLIME reaction +r_4087 phosphatidate (1-18:1, 2-18:1) [endoplasmic reticulum membrane] SLIME rxn phosphatidate (1-18:1, 2-18:1)[erm] => 0.70098 phosphatidate backbone[erm] + 0.56493 C18:1 chain[c] SLIME reaction +r_4088 diglyceride (1-16:0, 2-16:1) [endoplasmic reticulum membrane] SLIME rxn diglyceride (1-16:0, 2-16:1)[erm] => 0.56892 diglyceride backbone[erm] + 0.25643 C16:0 chain[c] + 0.25441 C16:1 chain[c] SLIME reaction +r_4089 diglyceride (1-16:0, 2-18:1) [endoplasmic reticulum membrane] SLIME rxn diglyceride (1-16:0, 2-18:1)[erm] => 0.59496 diglyceride backbone[erm] + 0.25643 C16:0 chain[c] + 0.28247 C18:1 chain[c] SLIME reaction +r_4090 diglyceride (1-16:1, 2-16:1) [endoplasmic reticulum membrane] SLIME rxn diglyceride (1-16:1, 2-16:1)[erm] => 0.56489 diglyceride backbone[erm] + 0.50883 C16:1 chain[c] SLIME reaction +r_4091 diglyceride (1-16:1, 2-18:1) [endoplasmic reticulum membrane] SLIME rxn diglyceride (1-16:1, 2-18:1)[erm] => 0.59294 diglyceride backbone[erm] + 0.25441 C16:1 chain[c] + 0.28247 C18:1 chain[c] SLIME reaction +r_4092 diglyceride (1-18:0, 2-16:1) [endoplasmic reticulum membrane] SLIME rxn diglyceride (1-18:0, 2-16:1)[erm] => 0.59496 diglyceride backbone[erm] + 0.25441 C16:1 chain[c] + 0.28448 C18:0 chain[c] SLIME reaction +r_4093 diglyceride (1-18:0, 2-18:1) [endoplasmic reticulum membrane] SLIME rxn diglyceride (1-18:0, 2-18:1)[erm] => 0.62301 diglyceride backbone[erm] + 0.28448 C18:0 chain[c] + 0.28247 C18:1 chain[c] SLIME reaction +r_4094 diglyceride (1-18:1, 2-16:1) [endoplasmic reticulum membrane] SLIME rxn diglyceride (1-18:1, 2-16:1)[erm] => 0.59294 diglyceride backbone[erm] + 0.25441 C16:1 chain[c] + 0.28247 C18:1 chain[c] SLIME reaction +r_4095 diglyceride (1-18:1, 2-18:1) [endoplasmic reticulum membrane] SLIME rxn diglyceride (1-18:1, 2-18:1)[erm] => 0.621 diglyceride backbone[erm] + 0.56493 C18:1 chain[c] SLIME reaction +r_4096 sn-2-acyl-1-lysophosphatidylinositol (16:1) [endoplasmic reticulum membrane] SLIME rxn sn-2-acyl-1-lysophosphatidylinositol (16:1)[erm] => 0.56457 sn-2-acyl-1-lysophosphatidylinositol backbone[erm] + 0.25441 C16:1 chain[c] SLIME reaction +r_4097 sn-2-acyl-1-lysophosphatidylinositol (18:1) [endoplasmic reticulum membrane] SLIME rxn sn-2-acyl-1-lysophosphatidylinositol (18:1)[erm] => 0.59262 sn-2-acyl-1-lysophosphatidylinositol backbone[erm] + 0.28247 C18:1 chain[c] SLIME reaction +r_4098 phosphatidylglycerol (1-16:0, 2-16:1) [mitochondrial membrane] SLIME rxn phosphatidylglycerol (1-16:0, 2-16:1)[mm] => 0.72097 phosphatidylglycerol backbone[mm] + 0.25643 C16:0 chain[c] + 0.25441 C16:1 chain[c] SLIME reaction +r_4099 phosphatidylglycerol (1-16:1, 2-16:1) [mitochondrial membrane] SLIME rxn phosphatidylglycerol (1-16:1, 2-16:1)[mm] => 0.71895 phosphatidylglycerol backbone[mm] + 0.50883 C16:1 chain[c] SLIME reaction +r_4100 phosphatidylglycerol (1-18:0, 2-16:1) [mitochondrial membrane] SLIME rxn phosphatidylglycerol (1-18:0, 2-16:1)[mm] => 0.74902 phosphatidylglycerol backbone[mm] + 0.25441 C16:1 chain[c] + 0.28448 C18:0 chain[c] SLIME reaction +r_4101 phosphatidylglycerol (1-18:1, 2-16:1) [mitochondrial membrane] SLIME rxn phosphatidylglycerol (1-18:1, 2-16:1)[mm] => 0.747 phosphatidylglycerol backbone[mm] + 0.25441 C16:1 chain[c] + 0.28247 C18:1 chain[c] SLIME reaction +r_4102 phosphatidylglycerol (1-16:0, 2-18:1) [mitochondrial membrane] SLIME rxn phosphatidylglycerol (1-16:0, 2-18:1)[mm] => 0.74902 phosphatidylglycerol backbone[mm] + 0.25643 C16:0 chain[c] + 0.28247 C18:1 chain[c] SLIME reaction +r_4103 phosphatidylglycerol (1-16:1, 2-18:1) [mitochondrial membrane] SLIME rxn phosphatidylglycerol (1-16:1, 2-18:1)[mm] => 0.747 phosphatidylglycerol backbone[mm] + 0.25441 C16:1 chain[c] + 0.28247 C18:1 chain[c] SLIME reaction +r_4104 cardiolipin (1-16:0, 2-16:1, 3-16:0, 4-16:1) [mitochondrial membrane] SLIME rxn cardiolipin (1-16:0, 2-16:1, 3-16:0, 4-16:1)[mm] => 1.3519 cardiolipin backbone[mm] + 0.51286 C16:0 chain[c] + 0.50883 C16:1 chain[c] SLIME reaction +r_4105 cardiolipin (1-16:0, 2-16:1, 3-16:1, 4-16:1) [mitochondrial membrane] SLIME rxn cardiolipin (1-16:0, 2-16:1, 3-16:1, 4-16:1)[mm] => 1.3478 cardiolipin backbone[mm] + 0.25643 C16:0 chain[c] + 0.76324 C16:1 chain[c] SLIME reaction +r_4106 cardiolipin (1-16:0, 2-16:1, 3-18:0, 4-16:1) [mitochondrial membrane] SLIME rxn cardiolipin (1-16:0, 2-16:1, 3-18:0, 4-16:1)[mm] => 1.3799 cardiolipin backbone[mm] + 0.25643 C16:0 chain[c] + 0.50883 C16:1 chain[c] + 0.28448 C18:0 chain[c] SLIME reaction +r_4107 cardiolipin (1-16:0, 2-16:1, 3-18:1, 4-16:1) [mitochondrial membrane] SLIME rxn cardiolipin (1-16:0, 2-16:1, 3-18:1, 4-16:1)[mm] => 1.3759 cardiolipin backbone[mm] + 0.25643 C16:0 chain[c] + 0.50883 C16:1 chain[c] + 0.28247 C18:1 chain[c] SLIME reaction +r_4108 cardiolipin (1-16:0, 2-16:1, 3-16:0, 4-18:1) [mitochondrial membrane] SLIME rxn cardiolipin (1-16:0, 2-16:1, 3-16:0, 4-18:1)[mm] => 1.3799 cardiolipin backbone[mm] + 0.51286 C16:0 chain[c] + 0.25441 C16:1 chain[c] + 0.28247 C18:1 chain[c] SLIME reaction +r_4109 cardiolipin (1-16:0, 2-16:1, 3-16:1, 4-18:1) [mitochondrial membrane] SLIME rxn cardiolipin (1-16:0, 2-16:1, 3-16:1, 4-18:1)[mm] => 1.3759 cardiolipin backbone[mm] + 0.25643 C16:0 chain[c] + 0.50883 C16:1 chain[c] + 0.28247 C18:1 chain[c] SLIME reaction +r_4110 cardiolipin (1-16:1, 2-16:1, 3-16:0, 4-16:1) [mitochondrial membrane] SLIME rxn cardiolipin (1-16:1, 2-16:1, 3-16:0, 4-16:1)[mm] => 1.3498 cardiolipin backbone[mm] + 0.25643 C16:0 chain[c] + 0.76324 C16:1 chain[c] SLIME reaction +r_4111 cardiolipin (1-16:1, 2-16:1, 3-16:1, 4-16:1) [mitochondrial membrane] SLIME rxn cardiolipin (1-16:1, 2-16:1, 3-16:1, 4-16:1)[mm] => 1.3458 cardiolipin backbone[mm] + 1.0177 C16:1 chain[c] SLIME reaction +r_4112 cardiolipin (1-16:1, 2-16:1, 3-18:0, 4-16:1) [mitochondrial membrane] SLIME rxn cardiolipin (1-16:1, 2-16:1, 3-18:0, 4-16:1)[mm] => 1.3779 cardiolipin backbone[mm] + 0.76324 C16:1 chain[c] + 0.28448 C18:0 chain[c] SLIME reaction +r_4113 cardiolipin (1-16:1, 2-16:1, 3-18:1, 4-16:1) [mitochondrial membrane] SLIME rxn cardiolipin (1-16:1, 2-16:1, 3-18:1, 4-16:1)[mm] => 1.3739 cardiolipin backbone[mm] + 0.76324 C16:1 chain[c] + 0.28247 C18:1 chain[c] SLIME reaction +r_4114 cardiolipin (1-16:1, 2-16:1, 3-16:0, 4-18:1) [mitochondrial membrane] SLIME rxn cardiolipin (1-16:1, 2-16:1, 3-16:0, 4-18:1)[mm] => 1.3779 cardiolipin backbone[mm] + 0.25643 C16:0 chain[c] + 0.50883 C16:1 chain[c] + 0.28247 C18:1 chain[c] SLIME reaction +r_4115 cardiolipin (1-16:1, 2-16:1, 3-16:1, 4-18:1) [mitochondrial membrane] SLIME rxn cardiolipin (1-16:1, 2-16:1, 3-16:1, 4-18:1)[mm] => 1.3739 cardiolipin backbone[mm] + 0.76324 C16:1 chain[c] + 0.28247 C18:1 chain[c] SLIME reaction +r_4116 cardiolipin (1-18:0, 2-16:1, 3-16:0, 4-16:1) [mitochondrial membrane] SLIME rxn cardiolipin (1-18:0, 2-16:1, 3-16:0, 4-16:1)[mm] => 1.3799 cardiolipin backbone[mm] + 0.25643 C16:0 chain[c] + 0.50883 C16:1 chain[c] + 0.28448 C18:0 chain[c] SLIME reaction +r_4117 cardiolipin (1-18:0, 2-16:1, 3-16:1, 4-16:1) [mitochondrial membrane] SLIME rxn cardiolipin (1-18:0, 2-16:1, 3-16:1, 4-16:1)[mm] => 1.3759 cardiolipin backbone[mm] + 0.76324 C16:1 chain[c] + 0.28448 C18:0 chain[c] SLIME reaction +r_4118 cardiolipin (1-18:0, 2-16:1, 3-18:0, 4-16:1) [mitochondrial membrane] SLIME rxn cardiolipin (1-18:0, 2-16:1, 3-18:0, 4-16:1)[mm] => 1.408 cardiolipin backbone[mm] + 0.50883 C16:1 chain[c] + 0.56897 C18:0 chain[c] SLIME reaction +r_4119 cardiolipin (1-18:0, 2-16:1, 3-18:1, 4-16:1) [mitochondrial membrane] SLIME rxn cardiolipin (1-18:0, 2-16:1, 3-18:1, 4-16:1)[mm] => 1.4039 cardiolipin backbone[mm] + 0.50883 C16:1 chain[c] + 0.28448 C18:0 chain[c] + 0.28247 C18:1 chain[c] SLIME reaction +r_4120 cardiolipin (1-18:0, 2-16:1, 3-16:0, 4-18:1) [mitochondrial membrane] SLIME rxn cardiolipin (1-18:0, 2-16:1, 3-16:0, 4-18:1)[mm] => 1.408 cardiolipin backbone[mm] + 0.25643 C16:0 chain[c] + 0.25441 C16:1 chain[c] + 0.28448 C18:0 chain[c] + 0.28247 C18:1 chain[c] SLIME reaction +r_4121 cardiolipin (1-18:0, 2-16:1, 3-16:1, 4-18:1) [mitochondrial membrane] SLIME rxn cardiolipin (1-18:0, 2-16:1, 3-16:1, 4-18:1)[mm] => 1.4039 cardiolipin backbone[mm] + 0.50883 C16:1 chain[c] + 0.28448 C18:0 chain[c] + 0.28247 C18:1 chain[c] SLIME reaction +r_4122 cardiolipin (1-18:1, 2-16:1, 3-16:0, 4-16:1) [mitochondrial membrane] SLIME rxn cardiolipin (1-18:1, 2-16:1, 3-16:0, 4-16:1)[mm] => 1.3779 cardiolipin backbone[mm] + 0.25643 C16:0 chain[c] + 0.50883 C16:1 chain[c] + 0.28247 C18:1 chain[c] SLIME reaction +r_4123 cardiolipin (1-18:1, 2-16:1, 3-16:1, 4-16:1) [mitochondrial membrane] SLIME rxn cardiolipin (1-18:1, 2-16:1, 3-16:1, 4-16:1)[mm] => 1.3739 cardiolipin backbone[mm] + 0.76324 C16:1 chain[c] + 0.28247 C18:1 chain[c] SLIME reaction +r_4124 cardiolipin (1-18:1, 2-16:1, 3-18:0, 4-16:1) [mitochondrial membrane] SLIME rxn cardiolipin (1-18:1, 2-16:1, 3-18:0, 4-16:1)[mm] => 1.4059 cardiolipin backbone[mm] + 0.50883 C16:1 chain[c] + 0.28448 C18:0 chain[c] + 0.28247 C18:1 chain[c] SLIME reaction +r_4125 cardiolipin (1-18:1, 2-16:1, 3-18:1, 4-16:1) [mitochondrial membrane] SLIME rxn cardiolipin (1-18:1, 2-16:1, 3-18:1, 4-16:1)[mm] => 1.4019 cardiolipin backbone[mm] + 0.50883 C16:1 chain[c] + 0.56493 C18:1 chain[c] SLIME reaction +r_4126 cardiolipin (1-18:1, 2-16:1, 3-16:0, 4-18:1) [mitochondrial membrane] SLIME rxn cardiolipin (1-18:1, 2-16:1, 3-16:0, 4-18:1)[mm] => 1.4059 cardiolipin backbone[mm] + 0.25643 C16:0 chain[c] + 0.25441 C16:1 chain[c] + 0.56493 C18:1 chain[c] SLIME reaction +r_4127 cardiolipin (1-18:1, 2-16:1, 3-16:1, 4-18:1) [mitochondrial membrane] SLIME rxn cardiolipin (1-18:1, 2-16:1, 3-16:1, 4-18:1)[mm] => 1.4019 cardiolipin backbone[mm] + 0.50883 C16:1 chain[c] + 0.56493 C18:1 chain[c] SLIME reaction +r_4128 cardiolipin (1-16:0, 2-18:1, 3-16:0, 4-16:1) [mitochondrial membrane] SLIME rxn cardiolipin (1-16:0, 2-18:1, 3-16:0, 4-16:1)[mm] => 1.3799 cardiolipin backbone[mm] + 0.51286 C16:0 chain[c] + 0.25441 C16:1 chain[c] + 0.28247 C18:1 chain[c] SLIME reaction +r_4129 cardiolipin (1-16:0, 2-18:1, 3-16:1, 4-16:1) [mitochondrial membrane] SLIME rxn cardiolipin (1-16:0, 2-18:1, 3-16:1, 4-16:1)[mm] => 1.3759 cardiolipin backbone[mm] + 0.25643 C16:0 chain[c] + 0.50883 C16:1 chain[c] + 0.28247 C18:1 chain[c] SLIME reaction +r_4130 cardiolipin (1-16:0, 2-18:1, 3-18:0, 4-16:1) [mitochondrial membrane] SLIME rxn cardiolipin (1-16:0, 2-18:1, 3-18:0, 4-16:1)[mm] => 1.408 cardiolipin backbone[mm] + 0.25643 C16:0 chain[c] + 0.25441 C16:1 chain[c] + 0.28448 C18:0 chain[c] + 0.28247 C18:1 chain[c] SLIME reaction +r_4131 cardiolipin (1-16:0, 2-18:1, 3-18:1, 4-16:1) [mitochondrial membrane] SLIME rxn cardiolipin (1-16:0, 2-18:1, 3-18:1, 4-16:1)[mm] => 1.4039 cardiolipin backbone[mm] + 0.25643 C16:0 chain[c] + 0.25441 C16:1 chain[c] + 0.56493 C18:1 chain[c] SLIME reaction +r_4132 cardiolipin (1-16:0, 2-18:1, 3-16:0, 4-18:1) [mitochondrial membrane] SLIME rxn cardiolipin (1-16:0, 2-18:1, 3-16:0, 4-18:1)[mm] => 1.408 cardiolipin backbone[mm] + 0.51286 C16:0 chain[c] + 0.56493 C18:1 chain[c] SLIME reaction +r_4133 cardiolipin (1-16:0, 2-18:1, 3-16:1, 4-18:1) [mitochondrial membrane] SLIME rxn cardiolipin (1-16:0, 2-18:1, 3-16:1, 4-18:1)[mm] => 1.4039 cardiolipin backbone[mm] + 0.25643 C16:0 chain[c] + 0.25441 C16:1 chain[c] + 0.56493 C18:1 chain[c] SLIME reaction +r_4134 cardiolipin (1-16:1, 2-18:1, 3-16:0, 4-16:1) [mitochondrial membrane] SLIME rxn cardiolipin (1-16:1, 2-18:1, 3-16:0, 4-16:1)[mm] => 1.3779 cardiolipin backbone[mm] + 0.25643 C16:0 chain[c] + 0.50883 C16:1 chain[c] + 0.28247 C18:1 chain[c] SLIME reaction +r_4135 cardiolipin (1-16:1, 2-18:1, 3-16:1, 4-16:1) [mitochondrial membrane] SLIME rxn cardiolipin (1-16:1, 2-18:1, 3-16:1, 4-16:1)[mm] => 1.3739 cardiolipin backbone[mm] + 0.76324 C16:1 chain[c] + 0.28247 C18:1 chain[c] SLIME reaction +r_4136 cardiolipin (1-16:1, 2-18:1, 3-18:0, 4-16:1) [mitochondrial membrane] SLIME rxn cardiolipin (1-16:1, 2-18:1, 3-18:0, 4-16:1)[mm] => 1.4059 cardiolipin backbone[mm] + 0.50883 C16:1 chain[c] + 0.28448 C18:0 chain[c] + 0.28247 C18:1 chain[c] SLIME reaction +r_4137 cardiolipin (1-16:1, 2-18:1, 3-18:1, 4-16:1) [mitochondrial membrane] SLIME rxn cardiolipin (1-16:1, 2-18:1, 3-18:1, 4-16:1)[mm] => 1.4019 cardiolipin backbone[mm] + 0.50883 C16:1 chain[c] + 0.56493 C18:1 chain[c] SLIME reaction +r_4138 cardiolipin (1-16:1, 2-18:1, 3-16:0, 4-18:1) [mitochondrial membrane] SLIME rxn cardiolipin (1-16:1, 2-18:1, 3-16:0, 4-18:1)[mm] => 1.4059 cardiolipin backbone[mm] + 0.25643 C16:0 chain[c] + 0.25441 C16:1 chain[c] + 0.56493 C18:1 chain[c] SLIME reaction +r_4139 cardiolipin (1-16:1, 2-18:1, 3-16:1, 4-18:1) [mitochondrial membrane] SLIME rxn cardiolipin (1-16:1, 2-18:1, 3-16:1, 4-18:1)[mm] => 1.4019 cardiolipin backbone[mm] + 0.50883 C16:1 chain[c] + 0.56493 C18:1 chain[c] SLIME reaction +r_4140 cardiolipin (1-18:1, 2-18:1, 3-16:0, 4-16:1) [mitochondrial membrane] SLIME rxn cardiolipin (1-18:1, 2-18:1, 3-16:0, 4-16:1)[mm] => 1.4059 cardiolipin backbone[mm] + 0.25643 C16:0 chain[c] + 0.25441 C16:1 chain[c] + 0.56493 C18:1 chain[c] SLIME reaction +r_4141 cardiolipin (1-18:1, 2-18:1, 3-16:1, 4-16:1) [mitochondrial membrane] SLIME rxn cardiolipin (1-18:1, 2-18:1, 3-16:1, 4-16:1)[mm] => 1.4019 cardiolipin backbone[mm] + 0.50883 C16:1 chain[c] + 0.56493 C18:1 chain[c] SLIME reaction +r_4142 cardiolipin (1-18:1, 2-18:1, 3-18:0, 4-16:1) [mitochondrial membrane] SLIME rxn cardiolipin (1-18:1, 2-18:1, 3-18:0, 4-16:1)[mm] => 1.434 cardiolipin backbone[mm] + 0.25441 C16:1 chain[c] + 0.28448 C18:0 chain[c] + 0.56493 C18:1 chain[c] SLIME reaction +r_4143 cardiolipin (1-18:1, 2-18:1, 3-18:1, 4-16:1) [mitochondrial membrane] SLIME rxn cardiolipin (1-18:1, 2-18:1, 3-18:1, 4-16:1)[mm] => 1.43 cardiolipin backbone[mm] + 0.25441 C16:1 chain[c] + 0.8474 C18:1 chain[c] SLIME reaction +r_4144 cardiolipin (1-18:1, 2-18:1, 3-16:0, 4-18:1) [mitochondrial membrane] SLIME rxn cardiolipin (1-18:1, 2-18:1, 3-16:0, 4-18:1)[mm] => 1.434 cardiolipin backbone[mm] + 0.25643 C16:0 chain[c] + 0.8474 C18:1 chain[c] SLIME reaction +r_4145 cardiolipin (1-18:1, 2-18:1, 3-16:1, 4-18:1) [mitochondrial membrane] SLIME rxn cardiolipin (1-18:1, 2-18:1, 3-16:1, 4-18:1)[mm] => 1.43 cardiolipin backbone[mm] + 0.25441 C16:1 chain[c] + 0.8474 C18:1 chain[c] SLIME reaction +r_4146 cardiolipin (1-16:0, 2-16:1, 3-18:1, 4-18:1) [mitochondrial membrane] SLIME rxn cardiolipin (1-16:0, 2-16:1, 3-18:1, 4-18:1)[mm] => 1.4039 cardiolipin backbone[mm] + 0.25643 C16:0 chain[c] + 0.25441 C16:1 chain[c] + 0.56493 C18:1 chain[c] SLIME reaction +r_4147 cardiolipin (1-16:1, 2-16:1, 3-18:1, 4-18:1) [mitochondrial membrane] SLIME rxn cardiolipin (1-16:1, 2-16:1, 3-18:1, 4-18:1)[mm] => 1.4019 cardiolipin backbone[mm] + 0.50883 C16:1 chain[c] + 0.56493 C18:1 chain[c] SLIME reaction +r_4148 cardiolipin (1-18:0, 2-16:1, 3-18:1, 4-18:1) [mitochondrial membrane] SLIME rxn cardiolipin (1-18:0, 2-16:1, 3-18:1, 4-18:1)[mm] => 1.432 cardiolipin backbone[mm] + 0.25441 C16:1 chain[c] + 0.28448 C18:0 chain[c] + 0.56493 C18:1 chain[c] SLIME reaction +r_4149 cardiolipin (1-18:1, 2-16:1, 3-18:1, 4-18:1) [mitochondrial membrane] SLIME rxn cardiolipin (1-18:1, 2-16:1, 3-18:1, 4-18:1)[mm] => 1.43 cardiolipin backbone[mm] + 0.25441 C16:1 chain[c] + 0.8474 C18:1 chain[c] SLIME reaction +r_4150 cardiolipin (1-16:0, 2-18:1, 3-18:1, 4-18:1) [mitochondrial membrane] SLIME rxn cardiolipin (1-16:0, 2-18:1, 3-18:1, 4-18:1)[mm] => 1.432 cardiolipin backbone[mm] + 0.25643 C16:0 chain[c] + 0.8474 C18:1 chain[c] SLIME reaction +r_4151 cardiolipin (1-16:1, 2-18:1, 3-18:1, 4-18:1) [mitochondrial membrane] SLIME rxn cardiolipin (1-16:1, 2-18:1, 3-18:1, 4-18:1)[mm] => 1.43 cardiolipin backbone[mm] + 0.25441 C16:1 chain[c] + 0.8474 C18:1 chain[c] SLIME reaction +r_4152 Cytochrome c apocytochrome-c-lyase Cytochrome c[m] <=> ferroheme b[m] + Apocytochrome c[m] YAL039C or YKL087C Porphyrin and chlorophyll metabolism +r_4153 (R)-Acetoin:NAD+ oxidoreductase H+[c] + NADH[c] + diacetyl[c] => (R)-acetoin[c] + NAD[c] YAL061W Butanoate metabolism +r_4154 Probable diacetyl reductase [(R)-acetoin forming] 2 (EC 1.1.1.303) NAD[n] + (R)-acetoin[n] <=> H+[c] + diacetyl[n] + NADH[n] YAL061W Butanoate metabolism +r_4155 Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial (Glu-AdT subunit B) (EC 6.3.5.-) (Cytochrome c oxidase assembly factor PET112) ATP[m] + H2O[m] + L-glutamyl-tRNA(Gln)[m] + L-glutamine[m] => ADP[m] + H+[m] + L-glutamate[m] + phosphate[m] + Gln-tRNA(Gln)[m] YBL080C tRNA metabolism https://www.yeastgenome.org/go/GO:0006399 +r_4156 Methionine aminopeptidase 2 (MAP 2) (MetAP 2) (EC 3.4.11.18) (Peptidase M) H2O[v] + Met-Ala[v] <=> L-methionine[v] + L-alanine[v] YBL091C or YLR244C Dipeptidases +r_4157 ADP-ribose 1''-phosphate phosphatase (EC 3.1.3.84) (EC 3.2.2.-) ([Protein ADP-ribosylglutamate] hydrolase) H2O[c] + ADP-D-ribose 1''-phosphate[c] <=> phosphate[c] + ADP-ribose[c] YBR022W or YMR087W Purine metabolism r_4160 +r_4158 NADPH2:quinone oxidoreductase H+[c] + NADPH[c] + 2 quinone[c] <=> NADP(+)[c] + 2 1,4-benzosemiquinone[c] YBR046C Ubiquinone and other terpenoid-quinone biosynthesis r_0021 +r_4159 UDP-N-acetylglucosamine transferase subunit ALG14 (Asparagine-linked glycosylation protein 14) UDP-N-acetyl-alpha-D-glucosamine[er] + N-Acetyl-D-glucosaminyldiphosphodolichol[er] <=> H+[er] + UDP[er] + N,N'-Chitobiosyldiphosphodolichol[er] YBR070C and YGL047W N-glycan biosynthesis +r_4160 ADP-ribose pyrophosphatase (EC 3.6.1.13) (ADP-ribose diphosphatase) (ADP-ribose phosphohydrolase) (Adenosine diphosphoribose pyrophosphatase) (ADPR-PPase) H2O[c] + ADP-ribose[c] <=> AMP[c] + 2 H+[c] + D-ribofuranose 5-phosphate[c] YBR111C Purine metabolism +r_4161 Probable vacuolar amino acid transporter YPQ3 (PQ-loop repeat-containing protein 3) (Protein RTC2) (Restriction of telomere capping protein 2) L-arginine[v] <=> L-arginine[c] YBR147W or YDR352W Transport [c, v] +r_4162 Probable vacuolar amino acid transporter YPQ3 (PQ-loop repeat-containing protein 3) (Protein RTC2) (Restriction of telomere capping protein 2) L-histidine[v] <=> L-histidine[c] YBR147W or YDR352W Transport [c, v] +r_4163 Probable vacuolar amino acid transporter YPQ3 (PQ-loop repeat-containing protein 3) (Protein RTC2) (Restriction of telomere capping protein 2) L-lysine[v] <=> L-lysine[c] YBR147W or YDR352W Transport [c, v] +r_4164 oxalate:CoA ligase (AMP-forming) ATP[p] + coenzyme A[p] + Oxalate[p] <=> AMP[p] + diphosphate[p] + Oxalyl-CoA[p] YBR222C Glyoxylate and dicarboxylate metabolism +r_4165 Glucosidase 2 subunit alpha (EC 3.2.1.84) (Alpha-glucosidase II subunit alpha) (Glucosidase II subunit alpha) (Reversal of TOR2 lethality protein 2) H2O[er] + G00171[er] <=> D-glucose[er] + G00010[er] YBR229C N-glycan biosynthesis +r_4166 Glucosidase 2 subunit alpha (EC 3.2.1.84) (Alpha-glucosidase II subunit alpha) (Glucosidase II subunit alpha) (Reversal of TOR2 lethality protein 2) H2O[er] + G00010[er] <=> D-glucose[er] + G00011[er] YBR229C N-glycan biosynthesis +r_4167 Vacuolar cation-chloride cotransporter 1 (Vacuolar homolog of CCC family protein 1) sodium[v] + potassium[v] + chloride[v] <=> potassium[c] + sodium[c] + chloride[c] YBR235W Transport [c, v] +r_4168 Probable metabolite transport protein YBR241C D-fructose[c] <=> D-fructose[v] YBR241C or YGL104C Transport [c, v] +r_4169 Probable metabolite transport protein YBR241C D-galactose[c] <=> D-galactose[v] YBR241C or YGL104C Transport [c, v] +r_4170 UDP-N-acetyl-D-glucosamine:dolichyl-phosphate N-acetyl-D-glucosamine phosphotransferase dolichyl phosphate[er] + UDP-N-acetyl-alpha-D-glucosamine[er] <=> N-Acetyl-D-glucosaminyldiphosphodolichol[er] + UMP[er] YBR243C N-glycan biosynthesis +r_4171 (5-glutamyl)-peptide:amino-acid 5-glutamyltransferase glutathione[c] + H2O[c] => L-cysteinylglycine[c] + L-glutamate[c] YBR281C and YNL191W Glutathione metabolism +r_4172 P-type cation-transporting ATPase (EC 3.6.3.3) (Cadmium resistance protein 2) (Cadmium-translocating P-type ATPase) (Cd(2+)-exporting ATPase) ATP[c] + H2O[c] + cadmium(2+)[c] => ADP[c] + H+[c] + phosphate[c] + cadmium(2+)[e] YBR295W Transport [c, e] +r_4173 L-cysteine:sulfur-acceptor sulfurtransferase (sulfur carrier)-H[m] + L-cysteine[m] <=> L-alanine[m] + (sulfur carrier)-SH[m] YCL017C Thiamine metabolism +r_4174 Probable ATP-dependent permease cholesterol[er] <=> cholesterol[erm] YCR011C Transport [erm, er] +r_4175 Putative aryl-alcohol dehydrogenase AAD3 (EC 1.1.1.-) NAD[c] + 3-chlorobenzyl alcohol[c] <=> H+[c] + NADH[c] + 3-chlorobenzaldehyde[c] YCR107W or YDL243C or YJR155W or YNL331C or YOL165C or YPL088W Methylglyoxal metabolism +r_4176 Putative aryl-alcohol dehydrogenase AAD3 (EC 1.1.1.-) NAD[c] + 3-hydroxybenzyl alcohol[c] <=> H+[c] + NADH[c] + 3-hydroxybenzaldehyde[c] YCR107W or YDL243C or YJR155W or YNL331C or YOL165C or YPL088W Methylglyoxal metabolism +r_4177 Putative aryl-alcohol dehydrogenase AAD3 (EC 1.1.1.-) NAD[c] + 3-methylbenzyl alcohol[c] <=> H+[c] + NADH[c] + 3-methylbenzaldehyde[c] YCR107W or YDL243C or YJR155W or YNL331C or YOL165C or YPL088W Methylglyoxal metabolism +r_4178 Putative aryl-alcohol dehydrogenase AAD3 (EC 1.1.1.-) NAD[c] + 4-isopropylbenzyl alcohol[c] <=> H+[c] + NADH[c] + p-cumic aldehyde[c] YCR107W or YDL243C or YJR155W or YNL331C or YOL165C or YPL088W Methylglyoxal metabolism +r_4179 Putative aryl-alcohol dehydrogenase AAD3 (EC 1.1.1.-) NAD[c] + 4-methylbenzyl alcohol[c] <=> H+[c] + NADH[c] + 4-methylbenzaldehyde[c] YCR107W or YDL243C or YJR155W or YNL331C or YOL165C or YPL088W Methylglyoxal metabolism +r_4180 Benzyl alcohol:NAD+ oxidoreductase NAD[c] + benzyl alcohol[c] <=> H+[c] + NADH[c] + benzaldehyde[c] YCR107W or YDL243C or YJR155W or YNL331C or YOL165C or YPL088W Methylglyoxal metabolism +r_4181 Manganese-transporting ATPase 1 (EC 3.6.3.-) ATP[c] + H2O[c] + Mn(2+)[c] <=> ADP[c] + H+[c] + phosphate[c] + Mn(2+)[er] YEL031W Transport [c, er] +r_4183 D-Mannitol:NAD+ 2-oxidoreductase NAD[c] + Mannitol[c] <=> D-fructose[c] + H+[c] + NADH[c] YEL070W or YNR073C Fructose and mannose metabolism +r_4184 4-hydroxy-4-methyl-2-oxoglutarate pyruvate-lyase (pyruvate-forming) 4-hydroxy-4-methyl-2-oxoglutarate[c] <=> 2 pyruvate[c] YER010C C5-branched dibasic acid metabolism +r_4185 oxaloacetate carboxy-lyase (pyruvate-forming) H+[c] + oxaloacetate[c] => carbon dioxide[c] + pyruvate[c] YER010C Pyruvate metabolism +r_4186 L-methionine:thioredoxin-disulfide S-oxidoreductase H2O[c] + L-methionine[c] + TRX1 disulphide[c] <=> H+[c] + TRX1[c] + L-methionine (S)-S-oxide[c] YER042W Cysteine and methionine metabolism +r_4187 L-proline:tRNA(Pro) ligase (AMP-forming) ATP[m] + L-proline[m] + tRNA(Pro)[m] => AMP[m] + diphosphate[m] + Pro-tRNA(Pro)[m] YER087W tRNA metabolism https://www.yeastgenome.org/go/GO:0006399 +r_4188 Glutathione-specific gamma-glutamylcyclotransferase (Gamma-GCG) (EC 4.3.2.-) glutathione[c] => L-cysteinylglycine[c] + 5-oxo-L-proline[c] YER163C Glutathione metabolism +r_4189 4a-hydroxytetrahydrobiopterin hydro-lyase 4a-Hydroxytetrahydrobiopterin[m] <=> H2O[m] + Dihydrobiopterin[m] YHL018W Folate biosynthesis +r_4190 superoxide:superoxide oxidoreductase 2 H+[m] + 2 superoxide[m] => hydrogen peroxide[m] + oxygen[m] YHR008C Superoxide metabolism https://www.yeastgenome.org/go/GO:0006801 +r_4191 2-Deoxy-D-glucose 6-phosphate phosphohydrolase H2O[c] + 2-deoxy-D-glucose 6-phosphate[c] <=> phosphate[c] + 2-deoxy-D-glucose[c] YHR043C or YHR044C Alternate carbon metabolism +r_4192 Cytochrome c lysine N-methyltransferase 1 (EC 2.1.1.59) S-adenosyl-L-methionine[c] + [cytochrome c]-L-lysine[c] <=> H+[c] + S-adenosyl-L-homocysteine[c] + [cytochrome c]-N6-methyl-L-lysine[c] YHR109W Lysine metabolism +r_4193 S-Adenosyl-L-methionine:histone-L-lysine N6-methyltransferase S-adenosyl-L-methionine[n] + L-lysine-[histone][n] <=> H+[n] + S-adenosyl-L-homocysteine[n] + N6-methyl-L-lysine-[histone][n] YHR119W or YDR440W or YJL168C Lysine metabolism +r_4194 Zinc transporter YKE4 Zn(2+)[c] <=> Zn(2+)[er] YIL023C Transport [c, er] +r_4195 Zinc transporter YKE4 Zn(2+)[m] <=> Zn(2+)[v] YMR243C or YOR316C Transport [m, v] +r_4196 NADH:ferricytochrome-b5 oxidoreductase NADH[erm] + 2 Ferricytochrome b5[erm] <=> H+[erm] + 2 Ferrocytochrome b5[erm] YIL043C or YML125C Amino sugar and nucleotide sugar metabolism +r_4197 NADH-cytochrome b5 reductase 1 (EC 1.6.2.2) (Microsomal cytochrome b reductase) (P35) NADH[m] + 2 Ferricytochrome b5[m] <=> H+[m] + NAD[m] + 2 Ferrocytochrome b5[m] YIL043C or YKL150W or YML125C Amino sugar and nucleotide sugar metabolism +r_4198 Benzil reductase ((S)-benzoin forming) IRC24 (EC 1.1.1.320) (Increased recombination centers protein 24) NADP(+)[c] + (S)-benzoin[c] <=> H+[c] + NADPH[c] + benzil[c] YIR036C Other +r_4199 Glutathione S-transferase 1 (EC 2.5.1.18) (GST-I) RX[er] + glutathione[er] <=> HX[er] + R-S-glutathione[er] YIR038C Glutathione metabolism +r_4200 Glutathione S-transferase 1 (EC 2.5.1.18) (GST-I) glutathione[c] + RX[c] <=> HX[c] + R-S-glutathione[c] YMR251W or YKR076W Glutathione metabolism +r_4201 Glutathione S-transferase 1 (EC 2.5.1.18) (GST-I) glutathione[m] + RX[m] <=> HX[m] + R-S-glutathione[m] YLL060C Glutathione metabolism +r_4202 L-methionine:oxidized-thioredoxin S-oxidoreductase H2O[c] + L-methionine[c] + TRX1 disulphide[c] <=> H+[c] + TRX1[c] + L-Methionine S-oxide[c] YKL069W Cysteine and methionine metabolism +r_4203 Vacuolar aminopeptidase 1 (EC 3.4.11.22) (Aminopeptidase yscI) (Leucine aminopeptidase IV) (LAPIV) (Lysosomal aminopeptidase III) (Polypeptidase) (Vacuolar aminopeptidase I) H2O[v] + Ala-Gly[v] <=> L-alanine[v] + L-glycine[v] YKL103C Dipeptidases +r_4204 Vacuolar aminopeptidase 1 (EC 3.4.11.22) (Aminopeptidase yscI) (Leucine aminopeptidase IV) (LAPIV) (Lysosomal aminopeptidase III) (Polypeptidase) (Vacuolar aminopeptidase I) H2O[v] + Ala-Leu[v] <=> L-leucine[v] + L-alanine[v] YKL103C Dipeptidases +r_4205 5-oxo-L-proline amidohydrolase (ATP-hydrolysing) ATP[c] + 2 H2O[c] + 5-oxo-L-proline[c] => ADP[c] + H+[c] + L-glutamate[c] + phosphate[c] YKL215C Glutathione metabolism +r_4206 threo-3-hydroxy-L-aspartate ammonia-lyase Threo-3-hydroxy-L-aspartate[c] <=> ammonium[c] + oxaloacetate[c] YKL218C Alanine, aspartate and glutamate metabolism r_0216 +r_4207 Glutathione S-transferase omega-like 2 (EC 2.5.1.18) (Extracellular mutant protein 4) (Glutathione-dependent dehydroascorbate reductase) (EC 1.8.5.1) RX[p] + glutathione[p] <=> HX[p] + R-S-glutathione[p] YGR154C Glutathione metabolism +r_4208 glutathione:dehydroascorbate oxidoreductase 2 glutathione[c] + dehydroascorbate[c] <=> glutathione disulfide[c] + ascorbate[c] YKR076W Glutathione metabolism +r_4209 Glutathione S-transferase omega-like 2 (EC 2.5.1.18) (Extracellular mutant protein 4) (Glutathione-dependent dehydroascorbate reductase) (EC 1.8.5.1) 2 glutathione[p] + dehydroascorbate[p] <=> glutathione disulfide[p] + ascorbate[p] YGR154C Glutathione metabolism +r_4210 urea hydro-lyase (cyanamide-forming) urea[c] <=> H2O[c] + Cyanamide[c] YFL061W or YNL335W Alternate carbon metabolism +r_4211 D-ribose 5-phosphate,D-glyceraldehyde 3-phosphate pyridoxal 5-phosphate-lyase (glutamine-hydrolyzing) glyceraldehyde 3-phosphate[c] + L-glutamine[c] + aldehydo-D-ribose 5-phosphate[c] <=> H+[c] + 3 H2O[c] + L-glutamate[c] + phosphate[c] + pyridoxal 5'-phosphate[c] YFL060C or YNL334C Vitamin b6 metabolism +r_4212 D-ribulose 5-phosphate,D-glyceraldehyde 3-phosphate pyridoxal 5-phosphate-lyase D-ribulose 5-phosphate[c] + glyceraldehyde 3-phosphate[c] + L-glutamine[c] <=> H+[c] + 3 H2O[c] + L-glutamate[c] + phosphate[c] + pyridoxal 5'-phosphate[c] YFL059W or YNL333W Vitamin b6 metabolism +r_4214 L-cysteinylglycine dipeptidase H2O[c] + L-cysteinylglycine[c] <=> L-cysteine[c] + L-glycine[c] YFR044C Glutathione metabolism +r_4215 Cys-Gly metallodipeptidase DUG1 (EC 3.4.13.-) (Deficient in utilization of glutathione protein 1) (GSH degradosomal complex subunit DUG1) H2O[c] + R-S-Cysteinylglycine[c] <=> L-glycine[c] + S-Substituted L-cysteine[c] YFR044C Glutathione metabolism +r_4216 riboflavin-5-phosphate phosphohydrolase FMN[c] + H2O[c] <=> phosphate[c] + riboflavin[c] YDL024C Riboflavin metabolism +r_4217 "Fe(II):oxygen oxidoreductase; Fe2+:oxygen oxidoreductase" 4 H+[m] + 4 iron(2+)[m] + oxygen[m] <=> 2 H2O[m] + 4 iron(3+)[m] YDL120W Porphyrin and chlorophyll metabolism +r_4218 D-aminoacyl-tRNA deacylase (DTD) (EC 3.1.1.96) (D-tyrosyl-tRNA(Tyr) deacylase) (Gly-tRNA(Ala) deacylase) (EC 3.1.1.-) H2O[c] + Glycyl-tRNA(Ala)[c] <=> H+[c] + L-glycine[c] + tRNA(Ala)[c] YDL219W tRNA metabolism https://www.yeastgenome.org/go/GO:0006399 +r_4219 D-aminoacyl-tRNA deacylase (DTD) (EC 3.1.1.96) (D-tyrosyl-tRNA(Tyr) deacylase) (Gly-tRNA(Ala) deacylase) (EC 3.1.1.-) H2O[c] + D-tyrosyl-tRNA(Tyr)[c] <=> H+[c] + tRNA(Tyr)[c] + D-tyrosine[c] YDL219W tRNA metabolism https://www.yeastgenome.org/go/GO:0006399 +r_4220 4-nitrophenyl phosphate phosphohydrolase H2O[c] + 4-nitrophenyl phosphate[c] <=> H+[c] + phosphate[c] + 4-nitrophenol[c] YDL236W Alternate carbon metabolism +r_4221 D-Iditol:NAD+ 2-oxidoreductase NAD[c] + L-iditol[c] <=> H+[c] + L-sorbose[c] + NADH[c] YDL246C Pentose and glucuronate interconversions +r_4222 ATP:alpha-D-galactose 1-phosphotransferase ATP[c] + alpha-D-Galactose[c] => ADP[c] + alpha-D-galactose 1-phosphate[c] + H+[c] YDR009W Galactose metabolism +r_4223 3-Hydroxy-2-methylpropanoyl-CoA hydrolase H2O[m] + 3-hydroxy-2-methylpropanoyl-CoA[m] => coenzyme A[m] + H+[m] + 3-hydroxy-2-methylpropanoate[m] YDR036C Valine, leucine and isoleucine metabolism +r_4224 Sodium transport ATPase 5 (EC 3.6.3.7) ATP[c] + H2O[c] + sodium[c] => ADP[c] + H+[c] + phosphate[c] + sodium[e] YDR038C or YDR039C or YDR040C Transport [c, e] +r_4225 Broad-range acid phosphatase DET1 (EC 3.1.3.-) (Decreased ergosterol transport protein 1) ATP[c] + H2O[c] + sterols[e] <=> ADP[c] + H+[c] + phosphate[c] + sterols[c] YDR051C or YOL075C Transport [c, e] +r_4226 L-Alanine:2-oxoglutarate aminotransferase 2-oxoglutarate[c] + L-alanine[c] <=> L-glutamate[c] + pyruvate[c] YDR111C Alanine, aspartate and glutamate metabolism +r_4227 2-phenylacetamide amidohydrolase H2O[c] + 2-Phenylacetamide[c] <=> ammonium[c] + phenylacetic acid[c] YDR242W Phenylalanine metabolism +r_4228 Indole-3-acetamide amidohydrolase H2O[c] + (Indol-3-yl)acetamide[c] => ammonium[c] + indole-3-acetate[c] YDR242W Tryptophan metabolism +r_4230 Probable amidase (EC 3.5.1.4) ammonium[c] + Acrylic acid[c] <=> H2O[c] + Acrylamide[c] YDR242W Alternate carbon metabolism +r_4231 Acylamide aminohydrolase H2O[c] + Benzamide[c] <=> ammonium[c] + Benzoate[c] YDR242W Other +r_4232 ATP:D-Gluconate 6-phosphotransferase ATP[c] + D-gluconate[c] => 6-phospho-D-gluconate[c] + ADP[c] + H+[c] YDR248C Pentose phosphate pathway +r_4233 S-Adenosyl-L-methionine:protein-C-terminal-S-farnesyl-L-cysteine O-methyltransferase S-adenosyl-L-methionine[c] + Protein C-terminal S-farnesyl-L-cysteine[c] <=> S-adenosyl-L-homocysteine[c] + Protein C-terminal S-farnesyl-L-cysteine methyl ester[c] YDR410C Terpenoid backbone biosynthesis +r_4234 Phosphatidylinositol N-acetylglucosaminyltransferase subunit GPI19 (GPI-GlcNAc transferase complex subunit GPI19) (GPI-GnT subunit GPI19) (EC 2.4.1.198) UDP-N-acetyl-alpha-D-glucosamine[er] + 1-phosphatidyl-1D-myo-inositol[er] <=> H+[er] + UDP[er] + G00143[er] YDR437W and YGR216C and YNL038W and YPL076W and YPL175W and YPL096C-A Glycosylphosphatidylinositol (gpi)-anchor biosynthesis +r_4236 (R)-lactate hydro-lyase (R)-lactate[c] + H+[c] <=> H2O[c] + methylglyoxal[c] YDR533C or YMR322C or YOR391C or YPL280W Pyruvate metabolism +r_4237 Calcium-transporting ATPase 2 (EC 3.6.3.8) (Vacuolar Ca(2+)-ATPase) H2O[v] + Ca(2+)[c] + ATP[v] => H+[v] + phosphate[v] + Ca(2+)[v] + ADP[v] YGL006W Transport [c, v] +r_4238 Calcium-transporting ATPase 2 (EC 3.6.3.8) (Golgi Ca(2+)-ATPase) H2O[g] + Ca(2+)[c] + ATP[g] => H+[g] + phosphate[g] + Ca(2+)[g] + ADP[g] YGL167C Transport [c, g] +r_4239 L-arginyl-tRNA(Arg):protein arginyltransferase Arg-tRNA(Arg)[c] + generic protein[c] <=> H+[c] + tRNA(Arg)[c] + L-Arginyl-protein[c] YGL017W tRNA metabolism https://www.yeastgenome.org/go/GO:0006399 +r_4240 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3 (Oligosaccharyl transferase subunit STT3) (EC 2.4.99.18) Protein asparagine[er] + G00008[er] <=> H+[er] + Dolichyl diphosphate[er] + G00009[er] YGL022W N-glycan biosynthesis +r_4241 Mannosyl-oligosaccharide glucosidase (EC 3.2.1.106) (Processing A-glucosidase I) (Glucosidase I) H2O[er] + G00009[er] <=> G00171[er] + D-glucose[er] YGL027C N-glycan biosynthesis +r_4242 Initiation-specific alpha-1,6-mannosyltransferase (EC 2.4.1.232) (Outer chain elongation protein 1) GDP-alpha-D-mannose[er] + G10694[er] <=> H+[er] + GDP[er] + G01813[er] YGL038C N-glycan biosynthesis +r_4243 Alpha-1,3/1,6-mannosyltransferase ALG2 (EC 2.4.1.132) (EC 2.4.1.257) (Asparagine-linked glycosylation protein 2) (GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase) (GDP-Man:Man(1)GlcNAc(2)-PP-dolichol mannosyltransferase) (GDP-Man:Man(2)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase) GDP-alpha-D-mannose[er] + G00003[er] <=> H+[er] + GDP[er] + G00004[er] YGL065C N-glycan biosynthesis +r_4244 GDP-D-mannose:D-Man-alpha-(1->3)-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol alpha-6-mannosyltransferase GDP-alpha-D-mannose[er] + G00004[er] <=> H+[er] + GDP[er] + G00005[er] YGL065C N-glycan biosynthesis +r_4245 2-O-(6-phospho-alpha-D-mannosyl)-D-glycerate 6-phosphomannohydrolase H2O[v] + 2-O-(6-phospho-alpha-D-mannosyl)-D-glycerate[v] => D-mannose 6-phosphate[v] + D-Glycerate[v] YGL156W Fructose and mannose metabolism r_0723 +r_4246 Alpha-mannosidase (EC 3.2.1.24) (Alpha-D-mannoside mannohydrolase) H2O[v] + alpha-D-mannoside[v] => alpha-D-mannopyranose[v] + non glycosylated sugar acceptor[v] YGL156W Fructose and mannose metabolism r_0723 +r_4247 ATP:L-threonyl,bicarbonate adenylyltransferase ATP[c] + bicarbonate[c] + L-threonine[c] => diphosphate[c] + H2O[c] + L-Threonylcarbamoyladenylate[c] YGL169W Threonylcarbamoyladenosine metabolism https://www.yeastgenome.org/go/GO:0070525 +r_4248 D-serine ammonia-lyase D-Serine[c] => ammonium[c] + pyruvate[c] YGL196W Glycine, serine and threonine metabolism +r_4249 "O3-acetyl-L-serine:hydrogen-sulfide 2-amino-2-carboxyethyltransferase; O3-acetyl-L-serine acetate-lyase (adding hydrogen sulfide)" O-acetyl-L-serine[m] + hydrogen sulfide[m] <=> acetate[m] + L-cysteine[m] YGR012W Cysteine and methionine metabolism +r_4250 Dolichyl-diphosphate phosphohydrolase H+[er] + H2O[er] + Dolichyl diphosphate[er] <=> dolichyl phosphate[er] + phosphate[er] YGR036C N-glycan biosynthesis +r_4251 CTP:phosphatidate cytidyltransferase CTP[m] + H+[m] + phosphatidate[m] <=> diphosphate[m] + CDP-diacylglycerol[m] YGR046W Glycerophospholipid metabolism +r_4252 Thiamine thiazole synthase (Thiazole biosynthetic enzyme) L-glycine[c] + NAD[c] + Sulfur donor[c] <=> 3 H2O[c] + nicotinamide[c] + ADP-5-ethyl-4-methylthiazole-2-carboxylate[c] YGR144W Thiamine metabolism +r_4253 dolichyl beta-D-glucosyl phosphate:D-Glc-alpha-(1->3)-D-Glc-alpha-(1->3)-D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->6)]-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol alpha-1,2-glucosyltransferase H+[er] + Dolichyl beta-D-glucosyl phosphate[er] + G10599[er] <=> dolichyl phosphate[er] + G00008[er] YGR227W N-glycan biosynthesis +r_4254 nitric oxide, NADH2:oxygen oxidoreductase NADH[c] + 2 oxygen[c] + 2 nitric oxide[c] => H+[c] + NAD[c] + 2 nitrate[c] YGR234W Nitrogen metabolism +r_4255 nitric oxide, NADPH2:oxygen oxidoreductase NADPH[c] + 2 oxygen[c] + 2 nitric oxide[c] => H+[c] + NADP(+)[c] + 2 nitrate[c] YGR234W Nitrogen metabolism +r_4256 Putative lipoate-protein ligase A (EC 6.3.1.20) (Altered inheritance rate of mitochondria protein 22) ATP[c] + H+[c] + (R)-Lipoate[c] => diphosphate[c] + Lipoyl-AMP[c] YJL046W Lipoic acid metabolism +r_4258 [lipoyl-carrier protein]-L-lysine:lipoate ligase (AMP-forming) ATP[c] + (R)-Lipoate[c] + Apoprotein[c] => AMP[c] + diphosphate[c] + Protein N6-(lipoyl)lysine[c] YJL046W Lipoic acid metabolism +r_4260 Deaminated glutathione amidase (dGSH amidase) (EC 3.5.1.-) (Nitrilase homolog 1) H2O[c] + N-(4-oxoglutarate)-L-cysteinylglycine[c] <=> 2-oxoglutarate[c] + L-cysteinylglycine[c] YJL126W Glutathione metabolism r_0457 +r_4261 Deaminated glutathione amidase (dGSH amidase) (EC 3.5.1.-) (Nitrilase homolog 1) H2O[m] + N-(4-oxoglutarate)-L-cysteinylglycine[m] <=> 2-oxoglutarate[m] + L-cysteinylglycine[m] YJL126W Glutathione metabolism r_0457 +r_4262 citrate hydroxymutase citrate[m] <=> isocitrate[m] YJL200C Lysine metabolism +r_4263 "Anion/proton exchange transporter GEF1 (CLC protein GEF1) (ClC-A) (ClC-Y1) (Voltage-gated chloride channel) [Cleaved into: GEF1 N-terminal; GEF1 C-terminal]" chloride[g] <=> chloride[c] YJR040W Transport [c, g] +r_4264 succinate:NAD+ oxidoreductase fumarate[m] + H+[m] + NADH[m] => NAD[m] + succinate[m] YJR051W Cellular response to anaerobic conditions https://www.yeastgenome.org/locus/S000003812 +r_4265 nucleoside-triphosphate diphosphohydrolase H2O[c] + ribonucleoside 5'-triphosphate[c] => diphosphate[c] + H+[c] + ribonucleoside 5'-phosphate[c] YJR069C Purine metabolism +r_4266 Inosine triphosphate pyrophosphatase (ITPase) (Inosine triphosphatase) (EC 3.6.1.9) (Hydroxylaminopurine sensitivity protein 1) (Non-canonical purine NTP pyrophosphatase) (Non-standard purine NTP pyrophosphatase) (Nucleoside-triphosphate diphosphatase) (Nucleoside-triphosphate pyrophosphatase) (NTPase) dATP[c] + H2O[c] => dAMP[c] + diphosphate[c] + H+[c] YJR069C Purine metabolism +r_4267 2'-Deoxyguanosine 5'-triphosphate diphosphohydrolase dGTP[c] + H2O[c] => dGMP[c] + diphosphate[c] + H+[c] YJR069C Purine metabolism +r_4268 dTTP diphosphohydrolase dTTP[c] + H2O[c] => diphosphate[c] + dTMP[c] + H+[c] YJR069C Purine metabolism +r_4269 Inosine triphosphate pyrophosphatase (ITPase) (Inosine triphosphatase) (EC 3.6.1.9) (Hydroxylaminopurine sensitivity protein 1) (Non-canonical purine NTP pyrophosphatase) (Non-standard purine NTP pyrophosphatase) (Nucleoside-triphosphate diphosphatase) (Nucleoside-triphosphate pyrophosphatase) (NTPase) H2O[c] + 2'-deoxyribonucleoside 5'-triphosphate[c] <=> diphosphate[c] + H+[c] + 2'-deoxyribonucleoside 5'-phosphate[c] YJR069C Purine metabolism +r_4270 superoxide:superoxide oxidoreductase 2 H+[c] + 2 superoxide[c] => hydrogen peroxide[c] + oxygen[c] YJR104C Superoxide metabolism https://www.yeastgenome.org/go/GO:0006801 +r_4271 Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase (EC 3.2.1.113) (ER alpha-1,2-mannosidase) (Man(9)-alpha-mannosidase) 4 H2O[er] + G00011[er] <=> G00012[er] + 4 D-mannose[er] YJR131W or YLR057W N-glycan biosynthesis +r_4272 alpha 1,2-mannosyloligosaccharide alpha-D-mannohydrolase H2O[er] + G00011[er] <=> G10694[er] + D-mannose[er] YJR131W or YLR057W N-glycan biosynthesis +r_4273 ethylnitronate:oxygen 2-oxidoreductase (nitrite-forming) FMNH2[c] + oxygen[c] + Ethylnitronate[c] <=> acetaldehyde[c] + FMN[c] + 2 H+[c] + H2O[c] + Nitrite[c] YJR149W Nitrogen metabolism +r_4274 "O-Succinyl-L-homoserine succinate-lyase (deaminating; 2-oxobutanoate-forming)" H2O[c] + O-succinyl-L-homoserine[c] => 2-oxobutanoate[c] + ammonium[c] + H+[c] + succinate[c] YLL058W or YML082W Cysteine and methionine metabolism +r_4275 Fe(II):NADP+ oxidoreductase NADPH[c] + 2 iron(3+)[e] <=> H+[c] + 2 iron(2+)[c] + NADP(+)[c] YLR047C or YKL220C or YLR214W or YNR060W or YOL152W or YOR381W or YOR384W Porphyrin and chlorophyll metabolism r_4217 +r_4276 Fe(II):NADP+ oxidoreductase NADPH[c] + 2 iron(3+)[v] <=> H+[c] + 2 iron(2+)[c] + NADP(+)[c] YLL051C Porphyrin and chlorophyll metabolism r_4217 +r_4277 acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase Acyl-CoA[er] + 1-acyl-sn-glycerol 3-phosphate[er] <=> coenzyme A[er] + 1,2-diacyl-sn-glycerol 3-phosphate[er] YLR099C or YPR139C Glycerolipid metabolism +r_4278 diphthine:ammonia ligase (AMP-forming) ammonium[c] + ATP[c] + Peptide diphthine[c] => AMP[c] + diphosphate[c] + H+[c] + Peptide diphthamide[c] YLR143W Peptidyl-diphthamide biosynthetic process https://www.yeastgenome.org/go/GO:0017183 +r_4279 8-oxo-dGTP diphosphohydrolase H2O[p] + 8-oxo-dGTP[p] => diphosphate[p] + H+[p] + 8-oxo-dGMP[p] YLR151C DNA repair https://www.yeastgenome.org/go/GO:0006281 +r_4280 octanoyl-[acp]:protein N6-octanoyltransferase octanoyl-ACP[m] + Apoprotein[m] <=> ACP1[m] + Protein N6-(octanoyl)lysine[m] YLR239C Lipoic acid metabolism +r_4281 lipoyl-[acp]:protein N6-lipoyltransferase Apoprotein[m] + Lipoyl-[acp][m] <=> ACP1[m] + Protein N6-(lipoyl)lysine[m] YLR239C Lipoic acid metabolism +r_4282 ATP:D-fructose-6-phosphate 2-phosphotransferase ATP[c] + beta-D-Fructose 6-phosphate[c] => ADP[c] + beta-D-fructose 2,6-bisphosphate[c] + H+[c] YLR345W Fructose and mannose metabolism +r_4283 ATP:D-fructose 6-phosphotransferase ATP[c] + D-fructose[c] => ADP[c] + H+[c] + beta-D-Fructose 6-phosphate[c] YLR446W Glycolysis / gluconeogenesis +r_4284 ATP:beta-D-glucose 6-phosphotransferase ATP[c] + beta-D-Glucose[c] => ADP[c] + H+[c] + beta-D-Glucose 6-phosphate[c] YLR446W Glycolysis / gluconeogenesis +r_4285 ATP:alpha-D-glucose 6-phosphotransferase ATP[c] + alpha-D-Glucose[c] => ADP[c] + H+[c] + alpha-D-Glucose 6-phosphate[c] YLR446W Glycolysis / gluconeogenesis +r_4286 ATP:D-glucosamine 6-phosphotransferase ATP[c] + D-Glucosamine[c] => ADP[c] + alpha-D-glucosamine 6-phosphate[c] + H+[c] YLR446W Glycolysis / gluconeogenesis +r_4287 ATP:D-fructose 6-phosphotransferase ATP[c] + beta-D-Fructose[c] => ADP[c] + H+[c] + beta-D-Fructose 6-phosphate[c] YLR446W Glycolysis / gluconeogenesis +r_4288 alpha-D-Glucose 6-phosphate ketol-isomerase alpha-D-Glucose 6-phosphate[c] <=> beta-D-Glucose 6-phosphate[c] YMR099C Glycolysis / gluconeogenesis +r_4291 D-Glyceraldehyde:NAD+ oxidoreductase D-glyceraldehyde[c] + H2O[c] + NAD[c] <=> 2 H+[c] + NADH[c] + D-Glycerate[c] YMR110C Glycerolipid metabolism +r_4292 4-Aminobutyraldehyde:NAD+ oxidoreductase 4-aminobutanal[c] + H2O[c] + NADP(+)[c] <=> gamma-aminobutyrate[c] + 2 H+[c] + NADPH[c] YMR110C Arginine and proline metabolism +r_4293 "4-aminobutanal:NAD+ 1-oxidoreductase; 4-aminobutyraldehyde:NAD+ oxidoreductase" 4-aminobutanal[c] + H2O[c] + NAD[c] => gamma-aminobutyrate[c] + 2 H+[c] + NADH[c] YMR110C Arginine and proline metabolism +r_4294 Indole-3-acetaldehyde:NAD+ oxidoreductase H2O[c] + indol-3-ylacetaldehyde[c] + NAD[c] => 2 H+[c] + indole-3-acetate[c] + NADH[c] YMR110C Tryptophan metabolism +r_4295 2-Propyn-1-al:NAD+ oxidoreductase H2O[c] + NAD[c] + 2-Propynal[c] <=> 2 H+[c] + NADH[c] + Propynoate[c] YMR110C Sphingolipid metabolism https://www.yeastgenome.org/locus/S000004716 +r_4296 D-Glucuronolactone:NAD+ oxidoreductase 2 H2O[c] + NAD[c] + D-Glucuronolactone[c] => 3 H+[c] + NADH[c] + D-Glucarate[c] YMR110C Ascorbate and aldarate metabolism +r_4297 "4-Trimethylammoniobutanal:NAD+ 1-oxidoreductase; 4-Trimethylammoniobutanal:NAD+ oxidoreductase" H2O[c] + NAD[c] + 4-Trimethylammoniobutanal[c] <=> 2 H+[c] + NADH[c] + 4-Trimethylammoniobutanoate[c] YMR110C Ascorbate and aldarate metabolism +r_4298 (S)-Methylmalonate semialdehyde:NAD+ oxidoreductase H2O[c] + NAD[c] + (S)-Methylmalonate semialdehyde[c] <=> 2 H+[c] + NADH[c] + Methylmalonate[c] YMR110C Valine, leucine and isoleucine metabolism +r_4299 Imidazole acetaldehyde:NAD+ oxidoreductase H2O[c] + NAD[c] + Imidazole-4-acetaldehyde[c] <=> 2 H+[c] + NADH[c] + Imidazole-4-acetate[c] YMR110C Histidine metabolism +r_4300 3alpha,7alpha-Dihydroxy-5beta-cholestan-26-al:NAD+ oxidoreductase H2O[c] + NAD[c] + 3alpha,7alpha-Dihydroxy-5beta-cholestan-26-al[c] <=> 2 H+[c] + NADH[c] + 3alpha,7alpha-Dihydroxy-5beta-cholestanate[c] YMR110C Sphingolipid metabolism https://www.yeastgenome.org/locus/S000004716 +r_4301 5-Hydroxyindoleacetaldehyde:NAD+ oxidoreductase H2O[c] + NAD[c] + 5-Hydroxyindoleacetaldehyde[c] <=> 2 H+[c] + NADH[c] + 5-Hydroxyindoleacetate[c] YMR110C Tryptophan metabolism +r_4302 N4-Acetylaminobutanal:NAD+ oxidoreductase H2O[c] + NAD[c] + N4-Acetylaminobutanal[c] <=> 2 H+[c] + NADH[c] + 4-Acetamidobutanoate[c] YMR110C Arginine and proline metabolism +r_4303 Fatty aldehyde dehydrogenase HFD1 (EC 1.2.1.3) H2O[c] + NAD[c] + trans-3-Chloroallyl aldehyde[c] <=> 2 H+[c] + NADH[c] + trans-3-Chloroacrylic acid[c] YMR110C Alternate carbon metabolism +r_4304 Fatty aldehyde dehydrogenase HFD1 (EC 1.2.1.3) H2O[c] + NAD[c] + cis-3-Chloroallyl aldehyde[c] <=> 2 H+[c] + NADH[c] + cis-3-Chloroacrylic acid[c] YMR110C Alternate carbon metabolism +r_4305 Chloroacetaldehyde:NAD+ oxidoreductase H2O[c] + NAD[c] + Chloroacetaldehyde[c] <=> 2 H+[c] + NADH[c] + Chloroacetic acid[c] YMR110C Alternate carbon metabolism +r_4306 Aldehyde:NAD+ oxidoreductase H2O[c] + NAD[c] + Perillyl aldehyde[c] <=> 2 H+[c] + NADH[c] + Perillic acid[c] YMR110C Alternate carbon metabolism +r_4307 farnesal:NAD+ oxidoreductase H2O[c] + NAD[c] + 2-trans,6-trans-Farnesal[c] <=> 2 H+[c] + NADH[c] + Farnesoic acid[c] YMR110C Insect hormone biosynthesis +r_4308 Probable phospholipid-transporting ATPase DNF3 (EC 3.6.3.1) (Aminophospholipid translocase) (APT) (Phospholipid translocase) (PLT) H2O[erm] + ATP[erm] + phospholipid[erm] => H+[erm] + phosphate[erm] + phospholipid[gm] + ADP[erm] YMR162C Transport [erm, gm] +r_4309 Putative esterase YMR210W (EC 3.1.1.-) H2O[c] + 1-oleoyl-sn-glycerol[c] => glycerol[c] + H+[c] + oleate[c] YMR210W Glycerophospholipid metabolism +r_4310 GDP-mannose:glycolipid 1,2-alpha-D-mannosyltransferase 2 GDP-alpha-D-mannose[er] + G00005[er] <=> 2 H+[er] + 2 GDP[er] + G10526[er] YNL048W N-glycan biosynthesis +r_4311 GDP-mannose:glycolipid 1,2-alpha-D-mannosyltransferase 2 GDP-alpha-D-mannose[er] + G10526[er] <=> 2 H+[er] + 2 GDP[er] + G00006[er] YNL048W N-glycan biosynthesis +r_4312 S-adenosyl-L-methionine:carnosine N-methyltransferase S-adenosyl-L-methionine[c] + carnosine[c] <=> H+[c] + S-adenosyl-L-homocysteine[c] + anserine[c] YNL092W Histidine metabolism +r_4313 Alpha-1,2-mannosyltransferase ALG9 (EC 2.4.1.259) (EC 2.4.1.261) (Asparagine-linked glycosylation protein 9) (Dol-P-Man:Man(6)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase) (Dol-P-Man:Man(8)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase) dolichyl D-mannosyl phosphate[er] + G10595[er] <=> dolichyl phosphate[er] + G10596[er] YNL219C N-glycan biosynthesis +r_4314 Alpha-1,2-mannosyltransferase ALG9 (EC 2.4.1.259) (EC 2.4.1.261) (Asparagine-linked glycosylation protein 9) (Dol-P-Man:Man(6)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase) (Dol-P-Man:Man(8)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase) dolichyl D-mannosyl phosphate[er] + G10597[er] <=> dolichyl phosphate[er] + G00007[er] YNL219C N-glycan biosynthesis +r_4315 Glycolate:NAD+ oxidoreductase NAD[c] + glycolate[c] <=> glyoxylate[c] + H+[c] + NADH[c] YNL274C Glyoxylate and dicarboxylate metabolism +r_4316 Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase (EC 2.4.1.260) (Asparagine-linked glycosylation protein 12) (Dolichyl-P-Man:Man(7)GlcNAc(2)-PP-dolichyl-alpha-1,6-mannosyltransferase) (Extracellular mutant protein 39) (Mannosyltransferase ALG12) dolichyl D-mannosyl phosphate[er] + G10596[er] <=> dolichyl phosphate[er] + G10597[er] YNR030W N-glycan biosynthesis +r_4317 sucrose glucohydrolase H2O[c] + sucrose[c] <=> D-fructose[c] + D-glucose[c] YOL157C Starch and sucrose metabolism +r_4318 Isomaltose 6-alpha-D-glucanohydrolase H2O[c] + Isomaltose[c] <=> D-glucose[c] + alpha-D-Glucose[c] YOL157C Starch and sucrose metabolism +r_4319 Dextrin 6-alpha-D-glucanohydrolase 2 H2O[c] + Dextrin[c] <=> 2 D-glucose[c] YOL157C Starch and sucrose metabolism +r_4320 dolichyl beta-D-glucosyl phosphate:D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->6)]-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol alpha-1,3-glucosyltransferase H+[er] + Dolichyl beta-D-glucosyl phosphate[er] + G00007[er] <=> dolichyl phosphate[er] + G10598[er] YOR002W N-glycan biosynthesis +r_4321 dolichyl beta-D-glucosyl phosphate:D-Glc-alpha-(1->3)-D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->6)]-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol alpha-1,3-glucosyltransferase H+[er] + Dolichyl beta-D-glucosyl phosphate[er] + G10598[er] <=> dolichyl phosphate[er] + G10599[er] YOR067C N-glycan biosynthesis +r_4322 GPI mannosyltransferase 4 (EC 2.4.1.-) (GPI mannosyltransferase IV) (GPI-MT-IV) dolichyl D-mannosyl phosphate[er] + G00149[er] <=> dolichyl phosphate[er] + H+[er] + G00140[er] YOR149C Glycosylphosphatidylinositol (gpi)-anchor biosynthesis +r_4323 protein N6-(octanoyl)lysine:sulfur sulfurtransferase 2 S-adenosyl-L-methionine[m] + Protein N6-(octanoyl)lysine[m] + 2 Sulfur donor[m] <=> 2 L-methionine[m] + Protein N6-(lipoyl)lysine[m] + 2 5'-Deoxyadenosine[m] YOR196C Lipoic acid metabolism +r_4324 octanoyl-[acp]:sulfur sulfurtransferase octanoyl-ACP[m] + 2 S-adenosyl-L-methionine[m] + 2 Sulfur donor[m] <=> 2 L-methionine[m] + Lipoyl-[acp][m] + 2 5'-Deoxyadenosine[m] YOR196C Lipoic acid metabolism +r_4325 Iron sulfur cluster assembly protein 2, mitochondrial (Iron sulfur cluster scaffold protein 2) S-sulfanyl-[L-cysteine desulfurase][m] + [disordered-form [Fe-S] cluster scaffold protein][m] => S-sulfanyl-[cysteine desulfurase]-[disordered-form scaffold protein] complex[m] YOR226C or YPL135W Cysteine and methionine metabolism r_0086 +r_4326 thiosulfate:cyanide sulfurtranserase hydrogen cyanide[m] + thiosulfate[m] <=> 2 H+[m] + sulphite[m] + thiocyanate[m] YOR251C or YOR285W or YOR286W Sulfur metabolism +r_4327 Magnesium transporter MRS2, mitochondrial (RNA-splicing protein MRS2) Mg(2+)[c] <=> Mg(2+)[m] YOR334W or YPL060W Transport [c, m] +r_4328 UDPglucose:dolichyl-phosphate beta-D-glucosyltransferase dolichyl phosphate[er] + UDP-D-glucose[er] <=> 2 H+[er] + UDP[er] + Dolichyl beta-D-glucosyl phosphate[er] YPL227C N-glycan biosynthesis +r_4329 Putative sulfate transporter YPR003C sulphate[c] <=> sulphate[er] YPR003C Transport [c, er] +r_4330 Pyridoxine:NADP+ 4-oxidoreductase NADP(+)[c] + pyridoxine[c] <=> H+[c] + NADPH[c] + pyridoxal[c] YPR127W Vitamin b6 metabolism +r_4331 [1,4-(N-Acetyl-beta-D-glucosaminyl)]n glycanohydrolase chitin[c] + H2O[c] <=> N-Acetyl-D-glucosamine[c] YDR371W or YLR286C Amino sugar and nucleotide sugar metabolism +r_4332 Protein PNS1 (pH nine-sensitive protein 1) choline[c] <=> choline[e] YOR161C Transport [c, e] +r_4333 Polyphosphate phosphohydrolase H2O[c] + polyphosphate[c] <=> H+[c] + 2 phosphate[c] YHR201C or YDR452W Purine metabolism +r_4334 Copper-transporting ATPase (EC 3.6.3.54) (Cu(2+)-ATPase) ATP[c] + H2O[c] + Cu2(+)[c] => ADP[c] + H+[c] + phosphate[c] + Cu2(+)[g] YDR270W Transport [c, g] +r_4335 Endopolyphosphatase (EC 3.6.1.10) (Deoxyadenosine triphosphate phosphohydrolase) (dATP phosphohydrolase) (EC 3.6.1.-) (Exopolyphosphatase) (EC 3.6.1.11) (Phosphate metabolism protein 5) dATP[c] + H2O[c] => dADP[c] + H+[c] + phosphate[c] YDR452W Purine metabolism r_4266 +r_4336 Monoamide of a dicarboxylic acid amidohydrolase H2O[c] + 2-Oxoglutaramate[c] <=> 2-oxoglutarate[c] + ammonium[c] YLR351C Alanine, aspartate and glutamate metabolism +r_4337 Iron-sulfur clusters transporter ATM1, mitochondrial ATP[m] + H2O[m] + porphyrin[m] <=> ADP[m] + H+[m] + phosphate[m] + porphyrin[c] YMR301C Transport [c, m] +r_4338 Oligo-1,6-glucosidase IMA2 (EC 3.2.1.10) (Alpha-glucosidase) (Isomaltase 2) H2O[c] + Starch[c] <=> 2 alpha-D-Glucose[c] YOL157C Starch and sucrose metabolism +r_4339 UDP-N-acetylglucosamine transporter YEA4 UDP-N-acetyl-alpha-D-glucosamine[er] <=> UDP-N-acetyl-alpha-D-glucosamine[g] YEL004W Transport [er, g] +r_4340 D-amino-acid N-acetyltransferase HPA3 (DNT) (EC 2.3.1.36) (EC 2.3.1.48) (Histone and other protein acetyltransferase 3) acetyl-CoA[c] + [protein]-L-lysine[c] <=> coenzyme A[c] + H+[c] + [protein]-N(6)-acetyl-L-lysine[c] YEL066W Phenylalanine metabolism +r_4341 glycerol 2-phosphate(2-) transport glycerol 2-phosphate(2-)[e] <=> glycerol 2-phosphate(2-)[c] Transport [c, e] +r_4342 Glycerol-2-phosphate phosphohydrolase H2O[c] + glycerol 2-phosphate(2-)[c] => glycerol[c] + phosphate[c] Glycerolipid metabolism r_0489 +r_4343 L-Threonine phosphate transport in via proton symport H+[e] + O-phospho-L-threonine[e] <=> H+[c] + O-phospho-L-threonine[c] Transport [c, e] +r_4344 acid phosphatase / phosphotransferase H2O[c] + O-phospho-L-threonine[c] => L-threonine[c] + phosphate[c] Glycine, serine and threonine metabolism +r_4345 alkaline phosphatase H2O[c] + guanosine 2'-monophosphate[c] => guanosine[c] + phosphate[c] Purine metabolism r_4412 +r_4346 Guanosine transport via proton symport H+[e] + guanosine 2'-monophosphate[e] <=> H+[c] + guanosine 2'-monophosphate[c] Transport [c, e] +r_4347 Guanosine 3'-phosphate phosphohydrolase H2O[c] + 3'-GMP[c] => guanosine[c] + phosphate[c] Purine metabolism +r_4348 Guanosine transport via proton symport(for 3'-GMP) H+[e] + 3'-GMP[e] <=> H+[c] + 3'-GMP[c] Transport [c, e] +r_4349 2-Phosphoglycolate transport in/out via proton symport H+[e] + 2-phosphoglycolate[e] <=> H+[c] + 2-phosphoglycolate[c] Transport [c, e] +r_4350 2-phosphoglycolate phosphohydrolase H2O[c] + 2-phosphoglycolate[c] => phosphate[c] + glycolate[c] Glyoxylate and dicarboxylate metabolism +r_4351 alkaline phosphatase H2O[c] + cysteamine S-phosphate[c] => phosphate[c] + cysteamine[c] Taurine and hypotaurine metabolism https://www.genome.jp/entry/K10712 +r_4352 cysteamine S-phosphate transport via proton symport cysteamine S-phosphate[e] <=> cysteamine S-phosphate[c] Transport [c, e] +r_4353 Cysteamine:oxygen oxidoreductase oxygen[c] + cysteamine[c] => H+[c] + hypotaurine[c] Taurine and hypotaurine metabolism +r_4354 hypotaurine:NAD+ oxidoreductase H2O[c] + NAD[c] + hypotaurine[c] => H+[c] + NADH[c] + taurine[c] Sulfur metabolism r_1029 +r_4355 2-aminobutanoate:2-oxoglutarate aminotransferase 2-oxobutanoate[c] + L-glutamate[c] <=> 2-oxoglutarate[c] + 2-aminobutanoate[c] Cysteine and methionine metabolism +r_4356 2-aminobutyrate transport H+[e] + 2-aminobutanoate[e] <=> H+[c] + 2-aminobutanoate[c] Transport [c, e] +r_4357 alkaline phosphatase H2O[c] + uridine 2'-phosphate[c] => phosphate[c] + uridine[c] Pyrimidine metabolism r_1077 +r_4358 Uridine 2'-phosphate transport in via proton symport H+[e] + uridine 2'-phosphate[e] <=> H+[c] + uridine 2'-phosphate[c] Transport [c, e] +r_4359 Uridine 3'-monophosphate phosphohydrolase H2O[c] + 3'-UMP[c] => phosphate[c] + uridine[c] Pyrimidine metabolism +r_4360 3'-UMP transport in via proton symport H+[e] + 3'-UMP[e] <=> H+[c] + 3'-UMP[c] Transport [c, e] +r_4361 Gly-Met transport via proton symport H+[e] + Gly-Met[e] <=> H+[c] + Gly-Met[c] YJR152W or YKR093W Transport [c, e] +r_4362 dipeptidase H2O[v] + Gly-Met[v] => L-methionine[v] + L-glycine[v] Dipeptidases +r_4363 R07420 N-phosphocreatine[c] => phosphate[c] + creatinine[c] Arginine and proline metabolism +r_4364 N-phosphocreatine transport H+[e] + N-phosphocreatine[e] <=> H+[c] + N-phosphocreatine[c] Transport [c, e] +r_4365 creatinine transport H+[e] + creatinine[e] <=> H+[c] + creatinine[c] Transport [c, e] +r_4366 ATP:L-arginine Nomega-phosphotransferase ADP[c] + H+[c] + N(omega)-phospho-L-arginine[c] <=> ATP[c] + L-arginine[c] Arginine and proline metabolism +r_4367 L-arginine phosphate transport in/out via proton symport H+[e] + N(omega)-phospho-L-arginine[e] <=> H+[c] + N(omega)-phospho-L-arginine[c] Transport [c, e] +r_4368 acid phosphatase / phosphotransferase H2O[c] + O(4)-phospho-L-tyrosine[c] => L-tyrosine[c] + phosphate[c] Tyrosine metabolism r_1063 +r_4369 Tripolyphosphate transport in via proton symport H+[e] + triphosphate[e] <=> H+[c] + triphosphate[c] Transport [c, e] +r_4370 alkaline phosphatase H2O[c] + cytidine 2'-phosphate[c] => cytidine[c] + phosphate[c] Pyrimidine metabolism r_0314 +r_4371 Cytidine- 2'- Monophosphate transport in via proton symport H+[e] + cytidine 2'-phosphate[e] <=> H+[c] + cytidine 2'-phosphate[c] Transport [c, e] +r_4372 cyclic phosphodiesterase H2O[c] + 2',3'-cyclic UMP[c] => H+[c] + uridine 2'-phosphate[c] Cyclic nucleotide metabolism https://www.yeastgenome.org/go/GO:0009187 +r_4373 2',3'-Cyclic UMP transport in via proton symport H+[e] + 2',3'-cyclic UMP[e] <=> H+[c] + 2',3'-cyclic UMP[c] Transport [c, e] +r_4374 3-Sulfino-L-alanine 4-carboxy-lyase H2O[c] + 3-sulfino-L-alanine[c] => H+[c] + L-alanine[c] + sulphite[c] Cysteine and methionine metabolism +r_4375 3-Sulfino-L-alanine transport via proton antiport H+[e] + 3-sulfino-L-alanine[e] <=> H+[c] + 3-sulfino-L-alanine[c] Transport [c, e] +r_4376 adenosine 3'-phosphate phosphohydrolase H2O[c] + 3'-AMP[c] => adenosine[c] + phosphate[c] Purine metabolism +r_4377 3AMP transport via diffusion (extracellular to periplasm) 3'-AMP[e] <=> 3'-AMP[c] Transport [c, e] +r_4378 alpha-glucosidase H2O[c] + 6-O-alpha-D-glucopyranosyl-D-fructofuranose[c] => D-fructose[c] + D-glucose[c] Starch and sucrose metabolism +r_4379 Palatinose transport in via proton symport H+[e] + 6-O-alpha-D-glucopyranosyl-D-fructofuranose[e] <=> H+[c] + 6-O-alpha-D-glucopyranosyl-D-fructofuranose[c] Transport [c, e] +r_4380 Amino-Acid N-Acetyltransferase coenzyme A[c] + H+[c] + N-acetyl-L-cysteine[c] <=> acetyl-CoA[c] + L-cysteine[c] Cysteine and methionine metabolism +r_4381 Acetylcysteine transport via proton symport H+[e] + N-acetyl-L-cysteine[e] <=> H+[c] + N-acetyl-L-cysteine[c] Transport [c, e] +r_4382 thiosulfate:ferricytochrome-c oxidoreductase 2 ferricytochrome c[m] + 2 thiosulfate[c] <=> 2 ferrocytochrome c[m] + tetrathionate[c] Oxidative phosphorylation r_0437 +r_4383 etrathionate transport via diffusion tetrathionate[e] <=> tetrathionate[c] Transport [c, e] +r_4384 D-Gluconate:NADP+ 5-oxidoreductase H+[c] + NADPH[c] + 5-dehydro-D-gluconate[c] => NADP(+)[c] + D-gluconate[c] Pentose phosphate pathway r_4566 +r_4385 5-Dehydro-D-gluconate transport via proton symport H+[e] + 5-dehydro-D-gluconate[e] <=> H+[c] + 5-dehydro-D-gluconate[c] Transport [c, e] +r_4386 dipeptidase H2O[v] + Ala-Asp[v] => L-aspartate[v] + L-alanine[v] Dipeptidases +r_4387 ala-L-asp-L transport via proton symport H+[e] + Ala-Asp[e] <=> H+[c] + Ala-Asp[c] YJR152W or YKR093W Transport [c, e] +r_4388 cyclic phosphodiesterase H2O[c] + 2',3'-cyclic CMP[c] => H+[c] + cytidine 2'-phosphate[c] Cyclic nucleotide metabolism https://www.yeastgenome.org/go/GO:0009187 +r_4389 2',3'-Cyclic CMP transport in via proton symport H+[e] + 2',3'-cyclic CMP[e] <=> H+[c] + 2',3'-cyclic CMP[c] Transport [c, e] +r_4390 beta-glucosidase (methyl-alpha-D-glucoside) H2O[c] + methyl alpha-D-glucopyranoside[c] <=> D-glucose[c] + methanol[c] Alternate carbon metabolism +r_4391 Methanol diffusion methanol[c] => methanol[e] Transport [c, e] +r_4392 alpha-Methyl-D-glucoside transport via proton symport H+[e] + methyl alpha-D-glucopyranoside[e] <=> H+[c] + methyl alpha-D-glucopyranoside[c] Transport [c, e] +r_4393 ATP:D-tagatose 6-phosphotransferase ATP[c] + D-tagatose[c] => ADP[c] + H+[c] + D-tagatofuranose 6-phosphate[c] Galactose metabolism +r_4394 D-tagatose 6-phosphate 4-epimerase D-tagatofuranose 6-phosphate[c] <=> D-fructose 6-phosphate[c] Galactose metabolism +r_4395 D-tagatose uptake via diffusion D-tagatose[e] <=> D-tagatose[c] YDL245C or YDR342C or YDR343C or YDR345C or YEL069C or YFL011W or YHR092C or YHR094C or YHR096C or YJL214W or YJL219W or YJR158W or YMR011W or YNR072W or YOL156W Transport [c, e] +r_4396 Acetoacetate:CoA ligase (AMP-forming) ATP[c] + coenzyme A[c] + acetoacetate[c] => acetoacetyl-CoA[c] + AMP[c] + diphosphate[c] Butanoate metabolism +r_4397 N-Acyl-Aliphatic-L-Amino Acid Amidohydrolase H2O[c] + N(alpha)-acetyl-L-methionine[c] <=> acetate[c] + L-methionine[c] Cysteine and methionine metabolism +r_4398 Ala-Gln transport via proton symport H+[e] + Ala-Gln[e] <=> H+[c] + Ala-Gln[c] YJR152W or YKR093W Transport [c, e] +r_4399 L-alanyl-L-glutamate transport in via proton symport H+[c] + Ala-Glu[c] <=> H+[v] + Ala-Glu[v] Transport [c, v] +r_4400 Maltodextrin glucosidase (maltotriose) H2O[e] + alpha-maltotriose[e] => D-glucose[e] + maltose[e] Starch and sucrose metabolism +r_4401 Ala-Thr transport via proton symport H+[c] + Ala-Thr[c] <=> H+[v] + Ala-Thr[v] Transport [c, v] +r_4402 Ala-Thr transport via proton symport (extracellular to cytosol) H+[e] + Ala-Thr[e] <=> H+[c] + Ala-Thr[c] YJR152W or YKR093W Transport [c, e] +r_4403 Triphosphate phosphohydrolase H2O[c] + triphosphate[c] => diphosphate[c] + phosphate[c] YHR201C or YDR452W Purine metabolism +r_4404 Gly-Asn transport via proton symport (extracellular to cytosol) H+[e] + Gly-Asn[e] <=> H+[c] + Gly-Asn[c] YJR152W or YKR093W Transport [c, e] +r_4405 glycerol 1-phosphate transport glycerol 1-phosphate[e] <=> glycerol 1-phosphate[c] Transport [c, e] +r_4406 D-O-Phosphoserine transport in/out via proton symport H+[e] + O-phosphonatooxy-D-serine(2-)[e] <=> H+[c] + O-phosphonatooxy-D-serine(2-)[c] Transport [c, e] +r_4407 D-O-Phosphoserine phosphohydrolase H2O[c] + O-phosphonatooxy-D-serine(2-)[c] <=> phosphate[c] + D-Serine[c] Glycine, serine and threonine metabolism +r_4408 L-alanyl-L-glutamate transport in via proton symport H+[e] + Ala-Glu[e] <=> H+[c] + Ala-Glu[c] YJR152W or YKR093W Transport [c, e] +r_4409 L-alanyl-gamma-L-glutamate peptidase H2O[v] + Ala-Glu[v] => L-glutamate[v] + L-alanine[v] Dipeptidases +r_4410 3-oxalomalate glyoxylate-lyase (oxaloacetate-forming) 3-oxalomalate(3-)[c] <=> glyoxylate[c] + oxaloacetate[c] Glyoxylate and dicarboxylate metabolism +r_4411 L-cysteate bisulfite-lyase (deaminating) H2O[c] + L-cysteate[c] => ammonium[c] + H+[c] + pyruvate[c] + sulphite[c] Cysteine and methionine metabolism +r_4412 cyclic phosphodiesterase H2O[c] + 2',3'-cyclic GMP[c] => H+[c] + guanosine 2'-monophosphate[c] Purine metabolism +r_4413 deoxynucleotide 3'-phosphatase H2O[c] + thymidine 3'-monophosphate[c] => phosphate[c] + thymidine[c] Pyrimidine metabolism r_2074 +r_4414 cytosol nonspecific dipeptidase H2O[v] + Ala-Gln[v] => L-glutamine[v] + L-alanine[v] Dipeptidases +r_4415 Cytosol non-specific dipeptidase H2O[v] + Ala-His[v] => L-histidine[v] + L-alanine[v] Dipeptidases +r_4416 Cytosol non-specific dipeptidase H2O[v] + Ala-Thr[v] => L-alanine[v] + L-threonine[v] Dipeptidases +r_4417 Cytosol non-specific dipeptidase H2O[v] + Gly-Asn[v] => L-asparagine[v] + L-glycine[v] Dipeptidases +r_4418 Cytosol non-specific dipeptidase H2O[v] + Gly-Gln[v] => L-glutamine[v] + L-glycine[v] Dipeptidases +r_4419 L-Cysteate transport via proton symport H+[e] + L-cysteate[e] <=> H+[c] + L-cysteate[c] Transport [c, e] +r_4420 alpha-glucosidase H2O[e] + turanose[e] <=> D-fructose[e] + D-glucose[e] Starch and sucrose metabolism r_0193 +r_4421 2-Hydroxyethanesulfonate transport via proton symport H+[e] + 2-hydroxyethane-1-sulfonate[e] <=> H+[c] + 2-hydroxyethane-1-sulfonate[c] Transport [c, e] +r_4422 3-Oxalomalate transport via proton symport H+[e] + 3-oxalomalate(3-)[e] <=> H+[c] + 3-oxalomalate(3-)[c] Transport [c, e] +r_4423 Gly-Met transport via proton symport H+[c] + Gly-Met[c] <=> H+[v] + Gly-Met[v] Transport [c, v] +r_4424 Gly-Gln transport via proton symport H+[e] + Gly-Gln[e] <=> H+[c] + Gly-Gln[c] YJR152W or YKR093W Transport [c, e] +r_4425 Gly-Gln transport via proton symport H+[c] + Gly-Gln[c] <=> H+[v] + Gly-Gln[v] Transport [c, v] +r_4426 Ala-Gln transport via proton symport H+[c] + Ala-Gln[c] <=> H+[v] + Ala-Gln[v] Transport [c, v] +r_4427 N-Acetylmethionine transport via proton symport H+[e] + N(alpha)-acetyl-L-methionine[e] <=> H+[c] + N(alpha)-acetyl-L-methionine[c] Transport [c, e] +r_4428 Phosphotyrosine transport via proton symport H+[e] + O(4)-phospho-L-tyrosine[e] <=> H+[c] + O(4)-phospho-L-tyrosine[c] Transport [c, e] +r_4429 Ala-His transport via proton symport H+[e] + Ala-His[e] <=> H+[c] + Ala-His[c] YJR152W or YKR093W Transport [c, e] +r_4430 Ala-His transport via proton symport H+[c] + Ala-His[c] <=> H+[v] + Ala-His[v] Transport [c, v] +r_4431 ala-L-asp-L transport via proton symport H+[c] + Ala-Asp[c] <=> H+[v] + Ala-Asp[v] Transport [c, v] +r_4432 FMNH2-dependent alkanesulfonate monooxygenase FMNH2[c] + oxygen[c] + 2-hydroxyethane-1-sulfonate[c] => FMN[c] + glycolaldehyde[c] + 2 H+[c] + H2O[c] + sulphite[c] Sulfur metabolism r_4326 +r_4433 thymidine 3-monophosphate transport thymidine 3'-monophosphate[e] <=> thymidine 3'-monophosphate[c] Transport [c, e] +r_4434 thymidine 5-monophosphate transport thymidine 5'-monophosphate[e] <=> thymidine 5'-monophosphate[c] Transport [c, e] +r_4435 glycerol-1-phosphate phosphohydrolase H2O[c] + glycerol 1-phosphate[c] => glycerol[c] + phosphate[c] YIL053W or YER062C Glycerolipid metabolism +r_4436 nucleotide-specific phosphatase (thymidine 5'-monophosphate) H2O[c] + thymidine 5'-monophosphate[c] => phosphate[c] + thymidine[c] Pyrimidine metabolism r_2074 +r_4437 Gly-Glu transport via proton symport (extracellular to cytosol) H+[e] + Gly-Glu[e] <=> H+[c] + Gly-Glu[c] YJR152W or YKR093W Transport [c, e] +r_4438 Gly-Glu transport via proton symport (cytosol to vacuole) H+[c] + Gly-Glu[c] <=> H+[v] + Gly-Glu[v] Transport [c, v] +r_4439 cytosol nonspecific dipeptidase H2O[v] + Gly-Glu[v] => L-glutamate[v] + L-glycine[v] Dipeptidases +r_4440 L-methionine transport, vacuoluar L-methionine[c] <=> L-methionine[v] Transport [c, v] +r_4441 L-threonine transport, vacuoluar L-threonine[c] <=> L-threonine[v] Transport [c, v] +r_4442 cysteamine exchange cysteamine[e] => Exchange reaction +r_4443 23cGMP transport via diffusion (extracellular to periplasm) 2',3'-cyclic GMP[e] <=> 2',3'-cyclic GMP[c] Transport [c, e] +r_4444 D-Glycerate 2-phosphate transport in/out via proton symport H+[e] + 2-phospho-D-glyceric acid[e] <=> 2-phospho-D-glyceric acid[c] + H+[c] Transport [c, e] +r_4445 3-Phospho-D-glycerate transport in/out via proton symport H+[e] + 3-phosphonato-D-glycerate(3-)[e] <=> 3-phosphonato-D-glycerate(3-)[c] + H+[c] Transport [c, e] +r_4446 D-glucose 1-phosphate transport via diffusion D-glucose 1-phosphate[e] <=> D-glucose 1-phosphate[c] Transport [c, e] +r_4447 carbamoyl phosphate nuclear transport via diffusion carbamoyl phosphate[e] <=> carbamoyl phosphate[c] Transport [c, e] +r_4448 Met-Ala transport via proton symport (extracellular to cytosol) H+[e] + Met-Ala[e] <=> H+[c] + Met-Ala[c] YJR152W or YKR093W Transport [c, e] +r_4449 Met-Ala transport via proton symport (cytosol to vacuole) H+[c] + Met-Ala[c] <=> H+[v] + Met-Ala[v] Transport [c, v] +r_4450 O-Phospho-L-serine transport in via proton symport H+[e] + 3-phospho-serine[e] <=> 3-phospho-serine[c] + H+[c] Transport [c, e] +r_4451 GMP transport via proton symport H+[e] + GMP[e] <=> GMP[c] + H+[c] Transport [c, e] +r_4452 myo-inositol phosphate transport via diffusion (extracellular to periplasm) myo-inositol hexakisphosphate[e] <=> myo-inositol hexakisphosphate[c] Transport [c, e] +r_4453 D-glucose 6-phosphate transport D-glucose 6-phosphate[e] <=> D-glucose 6-phosphate[c] Transport [c, e] +r_4454 UMP transport UMP[e] <=> UMP[c] Transport [c, e] +r_4455 Phosphoenolpyruvate transport in via proton symport H+[e] + phosphoenolpyruvate[e] <=> H+[c] + phosphoenolpyruvate[c] Transport [c, e] +r_4456 Mannose 6-phosphate transport via diffusion (extracellular to periplasm) D-mannose 6-phosphate[e] <=> D-mannose 6-phosphate[c] Transport [c, e] +r_4457 O-Phosphoryl-Ethanolamine transport in via proton symport H+[e] + O-phosphoethanolamine[e] <=> H+[c] + O-phosphoethanolamine[c] YDR093W Transport [c, e] +r_4458 6-Phospho-D-gluconate transport in/out via proton symport H+[e] + 6-phospho-D-gluconate[e] <=> 6-phospho-D-gluconate[c] + H+[c] Transport [c, e] +r_4459 MAN1P transport in/out via proton symport H+[e] + D-mannose 1-phosphate[e] <=> D-mannose 1-phosphate[c] + H+[c] Transport [c, e] +r_4460 Pyrophosphate transport in via proton symport 2 H+[e] + diphosphate[e] <=> diphosphate[c] + 2 H+[c] Transport [c, e] +r_4461 Choline phosphate intracellular transport choline phosphate[e] <=> choline phosphate[c] Transport [c, e] +r_4462 thiosulfate transport thiosulfate[e] <=> thiosulfate[c] Transport [c, e] +r_4463 AMP transport in/out via proton symport H+[e] + AMP[e] <=> AMP[c] + H+[c] Transport [c, e] +r_4464 23cAMP transport via diffusion (extracellular to periplasm) 2',3'-cyclic AMP[e] <=> 2',3'-cyclic AMP[c] Transport [c, e] +r_4465 Adenosine- 2'-Monophosphate transport in via proton symport H+[e] + adenosine 2'-phosphate[e] <=> adenosine 2'-phosphate[c] + H+[c] Transport [c, e] +r_4466 CMP transport in/out via proton symport H+[e] + CMP[e] <=> CMP[c] + H+[c] Transport [c, e] +r_4467 D-glucosamine transport via diffusion (extracellular to periplasm) D-Glucosamine[e] <=> D-Glucosamine[c] Transport [c, e] +r_4468 2-deoxy-D-ribose transport 2-deoxy-D-ribose[e] <=> 2-deoxy-D-ribose[c] YDR342C or YHR092C Transport [c, e] +r_4469 L-Citrulline transport in via proton symport H+[e] + L-citrulline[e] <=> H+[c] + L-citrulline[c] YKR039W Transport [c, e] +r_4470 Dihydroxyacetone transport via facilitated diffusion glycerone[e] <=> glycerone[c] Transport [c, e] +r_4471 Ala-Leu transport via proton symport (extracellular to cytosol) H+[e] + Ala-Leu[e] <=> H+[c] + Ala-Leu[c] YJR152W or YKR093W Transport [c, e] +r_4472 Ala-Leu transport via proton symport (cytosol to vacuole) H+[c] + Ala-Leu[c] <=> H+[v] + Ala-Leu[v] Transport [c, v] +r_4473 L-alanylglycine transport via proton antiport H+[e] + Ala-Gly[e] <=> H+[c] + Ala-Gly[c] YJR152W or YKR093W Transport [c, e] +r_4474 L-alanylglycine transport via proton antiport H+[c] + Ala-Gly[c] <=> H+[v] + Ala-Gly[v] Transport [c, v] +r_4475 N-acetyl-L-glutamate transport N-acetyl-L-glutamate[e] <=> N-acetyl-L-glutamate[c] Transport [c, e] +r_4476 N-acetyl-L-glutamate transport N-acetyl-L-glutamate[c] <=> N-acetyl-L-glutamate[m] Transport [c, m] +r_4477 Lipoamide transport via proton symport H+[e] + lipoamide[e] <=> H+[c] + lipoamide[c] Transport [c, e] +r_4478 L-methionine S-oxide transport via diffusion (extracellular) L-Methionine S-oxide[e] <=> L-Methionine S-oxide[c] Transport [c, e] +r_4479 Gly-Asn transport via proton symport H+[c] + Gly-Asn[c] <=> H+[v] + Gly-Asn[v] Transport [c, v] +r_4480 Cysteamine transport via proton antiport H+[e] + cysteamine[e] <=> H+[c] + cysteamine[c] Transport [c, e] +r_4481 Hydrogen sulfide oxidation hydrogen sulfide[c] + 2 oxygen[c] => H+[c] + sulphate[c] Sulfur metabolism +r_4482 L-alanine transport in via proton symport H+[c] + L-alanine[c] <=> H+[v] + L-alanine[v] Transport [c, v] +r_4483 Glycine transport (vacuole) H+[c] + L-glycine[c] <=> H+[v] + L-glycine[v] Transport [c, v] +r_4484 "O4-succinyl-L-homoserine:hydrogen sulfide S-(3-amino-3-carboxypropyl)transferase; O-succinyl-L-homoserine succinate-lyase (adding hydrogen sulfide)" hydrogen sulfide[c] + O-succinyl-L-homoserine[c] <=> L-homocysteine[c] + succinate[c] YJR130C or YLL058W or YML082W Cysteine and methionine metabolism +r_4485 4-Hydroxyphenylpyruvate:oxygen oxidoreductase (hydroxylating,decarboxylating) 3-(4-hydroxyphenyl)pyruvate[c] + oxygen[c] => carbon dioxide[c] + homogentisate[c] Tyrosine metabolism +r_4486 Homogentisate:oxygen 1,2-oxidoreductase (decyclizing) oxygen[c] + homogentisate[c] => H+[c] + 4-maleylacetoacetate[c] Tyrosine metabolism +r_4487 4-Maleylacetoacetate cis-trans-isomerase 4-maleylacetoacetate[c] => 4-fumarylacetoacetate[c] Tyrosine metabolism +r_4488 4-fumarylacetoacetate fumarylhydrolase H2O[c] + 4-fumarylacetoacetate[c] => fumarate[c] + H+[c] + acetoacetate[c] Tyrosine metabolism +r_4489 L-arabinitol:NAD+ 4-oxidoreductase (L-xylulose-forming) L-arabinitol[c] + NAD[c] => H+[c] + NADH[c] + L-xylulose[c] Pentose and glucuronate interconversions +r_4490 Xylitol:NADP+ 4-oxidoreductase (L-xylulose-forming) H+[c] + NADPH[c] + L-xylulose[c] <=> NADP(+)[c] + xylitol[c] Pentose and glucuronate interconversions +r_4491 arabinose reductase (D-arabinose) D-arabinose[c] + H+[c] + NADPH[c] => NADP(+)[c] + D-arabinitol[c] Alternate carbon metabolism +r_4492 D-arabinitol:NAT 4-oxidoreductase NAD[c] + D-arabinitol[c] => D-xylulose[c] + H+[c] + NADH[c] Pentose and glucuronate interconversions +r_4493 Acetoacetate transport via diffusion acetoacetate[e] <=> acetoacetate[c] YNL065W Transport [c, e] +r_4494 methanol exchange methanol[e] => Exchange reaction +r_4495 alkaline phosphatase adenosine 2'-phosphate[c] + H2O[c] => adenosine[c] + phosphate[c] Purine metabolism r_0140 +r_4496 Ala-Gly exchange Ala-Gly[e] => Exchange reaction +r_4497 3-oxalomalate(3-) exchange 3-oxalomalate(3-)[e] => Exchange reaction +r_4498 6-O-alpha-D-glucopyranosyl-D-fructofuranose exchange 6-O-alpha-D-glucopyranosyl-D-fructofuranose[e] => Exchange reaction +r_4499 5-dehydro-D-gluconate exchange 5-dehydro-D-gluconate[e] => Exchange reaction +r_4500 D-tagatose exchange D-tagatose[e] => Exchange reaction +r_4501 turanose exchange turanose[e] => Exchange reaction +r_4502 D-glucose 6-phosphate exchange D-glucose 6-phosphate[e] => Exchange reaction +r_4503 alpha-maltotriose exchange alpha-maltotriose[e] => Exchange reaction +r_4504 D-glucose 1-phosphate exchange D-glucose 1-phosphate[e] => Exchange reaction +r_4505 methyl alpha-D-glucopyranoside exchange methyl alpha-D-glucopyranoside[e] => Exchange reaction +r_4506 D-Glucosamine exchange D-Glucosamine[e] => Exchange reaction +r_4507 glycerone exchange glycerone[e] => Exchange reaction +r_4508 Ala-Gln exchange Ala-Gln[e] => Exchange reaction +r_4509 Ala-Leu exchange Ala-Leu[e] => Exchange reaction +r_4510 Gly-Gln exchange Gly-Gln[e] => Exchange reaction +r_4511 Ala-His exchange Ala-His[e] => Exchange reaction +r_4512 Gly-Asn exchange Gly-Asn[e] => Exchange reaction +r_4513 Ala-Glu exchange Ala-Glu[e] => Exchange reaction +r_4514 Gly-Met exchange Gly-Met[e] => Exchange reaction +r_4515 Ala-Asp exchange Ala-Asp[e] => Exchange reaction +r_4516 Gly-Glu exchange Gly-Glu[e] => Exchange reaction +r_4517 Ala-Thr exchange Ala-Thr[e] => Exchange reaction +r_4518 Met-Ala exchange Met-Ala[e] => Exchange reaction +r_4519 L-citrulline exchange L-citrulline[e] => Exchange reaction +r_4520 2-aminobutanoate exchange 2-aminobutanoate[e] => Exchange reaction +r_4521 choline phosphate exchange choline phosphate[e] => Exchange reaction +r_4522 glycerol 1-phosphate exchange glycerol 1-phosphate[e] => Exchange reaction +r_4523 2-phospho-D-glyceric acid exchange 2-phospho-D-glyceric acid[e] => Exchange reaction +r_4524 GMP exchange GMP[e] => Exchange reaction +r_4525 3-phospho-serine exchange 3-phospho-serine[e] => Exchange reaction +r_4526 O-phosphonatooxy-D-serine(2-) exchange O-phosphonatooxy-D-serine(2-)[e] => Exchange reaction +r_4527 diphosphate exchange diphosphate[e] => Exchange reaction +r_4528 triphosphate exchange triphosphate[e] => Exchange reaction +r_4529 phosphoenolpyruvate exchange phosphoenolpyruvate[e] => Exchange reaction +r_4530 N(omega)-phospho-L-arginine exchange N(omega)-phospho-L-arginine[e] => Exchange reaction +r_4531 carbamoyl phosphate exchange carbamoyl phosphate[e] => Exchange reaction +r_4532 O-phosphoethanolamine exchange O-phosphoethanolamine[e] => Exchange reaction +r_4533 cysteamine S-phosphate exchange cysteamine S-phosphate[e] => Exchange reaction +r_4534 guanosine 2'-monophosphate exchange guanosine 2'-monophosphate[e] => Exchange reaction +r_4535 glycerol 2-phosphate(2-) exchange glycerol 2-phosphate(2-)[e] => Exchange reaction +r_4536 3'-GMP exchange 3'-GMP[e] => Exchange reaction +r_4537 2-phosphoglycolate exchange 2-phosphoglycolate[e] => Exchange reaction +r_4538 6-phospho-D-gluconate exchange 6-phospho-D-gluconate[e] => Exchange reaction +r_4539 D-mannose 6-phosphate exchange D-mannose 6-phosphate[e] => Exchange reaction +r_4540 2',3'-cyclic GMP exchange 2',3'-cyclic GMP[e] => Exchange reaction +r_4541 O(4)-phospho-L-tyrosine exchange O(4)-phospho-L-tyrosine[e] => Exchange reaction +r_4542 O-phospho-L-threonine exchange O-phospho-L-threonine[e] => Exchange reaction +r_4543 3-phosphonato-D-glycerate(3-) exchange 3-phosphonato-D-glycerate(3-)[e] => Exchange reaction +r_4544 adenosine 2'-phosphate exchange adenosine 2'-phosphate[e] => Exchange reaction +r_4545 3'-AMP exchange 3'-AMP[e] => Exchange reaction +r_4546 2',3'-cyclic AMP exchange 2',3'-cyclic AMP[e] => Exchange reaction +r_4547 D-mannose 1-phosphate exchange D-mannose 1-phosphate[e] => Exchange reaction +r_4548 AMP exchange AMP[e] => Exchange reaction +r_4549 N(alpha)-acetyl-L-methionine exchange N(alpha)-acetyl-L-methionine[e] => Exchange reaction +r_4550 L-Methionine S-oxide exchange L-Methionine S-oxide[e] => Exchange reaction +r_4551 3-sulfino-L-alanine exchange 3-sulfino-L-alanine[e] => Exchange reaction +r_4552 N-acetyl-L-cysteine exchange N-acetyl-L-cysteine[e] => Exchange reaction +r_4553 L-cysteate exchange L-cysteate[e] => Exchange reaction +r_4554 2-hydroxyethane-1-sulfonate exchange 2-hydroxyethane-1-sulfonate[e] => Exchange reaction +r_4555 acetoacetate exchange acetoacetate[e] => Exchange reaction +r_4556 N-acetyl-L-glutamate exchange N-acetyl-L-glutamate[e] => Exchange reaction +r_4557 UMP exchange UMP[e] => Exchange reaction +r_4558 CMP exchange CMP[e] => Exchange reaction +r_4559 thymidine 5'-monophosphate exchange thymidine 5'-monophosphate[e] => Exchange reaction +r_4560 thymidine 3'-monophosphate exchange thymidine 3'-monophosphate[e] => Exchange reaction +r_4561 cytidine 2'-phosphate exchange cytidine 2'-phosphate[e] => Exchange reaction +r_4562 uridine 2'-phosphate exchange uridine 2'-phosphate[e] => Exchange reaction +r_4563 3'-UMP exchange 3'-UMP[e] => Exchange reaction +r_4564 2',3'-cyclic CMP exchange 2',3'-cyclic CMP[e] => Exchange reaction +r_4565 2',3'-cyclic UMP exchange 2',3'-cyclic UMP[e] => Exchange reaction +r_4566 ATP:D-Gluconate 6-phosphotransferase 6-phospho-D-gluconate[c] + ADP[c] + H+[c] => ATP[c] + D-gluconate[c] Pentose phosphate pathway +r_4567 6-phosphogluconate phosphatase 6-phospho-D-gluconate[c] + H2O[c] => phosphate[c] + D-gluconate[c] Pentose phosphate pathway r_4566 +r_4568 R06790 H+[c] + phenylacetic acid[c] => 4-hydroxyphenyl acetate[c] Phenylalanine metabolism +r_4569 Carboxylic ester hydrolases acetate[c] + H+[c] + Hydroquinone[c] => H2O[c] + 4-hydroxyphenyl acetate[c] Alternate carbon metabolism +r_4570 phosphoglycerate dehydrogenase NAD[c] + 2-hydroxyglutarate[c] <=> 2-oxoglutarate[c] + H+[c] + NADH[c] Glycine, serine and threonine metabolism +r_4571 seed:rxn00681 coenzyme A[c] + H+[c] + 2-hydroxyglutarate[c] <=> glyoxylate[c] + H2O[c] + propionyl-CoA[c] Glyoxylate and dicarboxylate metabolism r_4582 +r_4572 beta-alanine:2-oxoglutarate aminotransferase 2-oxoglutarate[c] + beta-alanine[c] <=> L-glutamate[c] + 3-oxopropanoate[c] Beta-alanine metabolism +r_4573 3-Oxopropanoate:NAD+ oxidoreductase (decarboxylating, CoA-acetylating) coenzyme A[c] + NAD[c] + 3-oxopropanoate[c] => acetyl-CoA[c] + carbon dioxide[c] + NADH[c] Beta-alanine metabolism +r_4574 3-Oxopropanoate:NADP+ oxidoreductase (decarboxylating, CoA-acetylating) coenzyme A[c] + NADP(+)[c] + 3-oxopropanoate[c] => acetyl-CoA[c] + carbon dioxide[c] + NADPH[c] Beta-alanine metabolism +r_4575 3-oxopropanoate carboxy-lyase H+[c] + 3-oxopropanoate[c] => acetaldehyde[c] + carbon dioxide[c] Alternate carbon metabolism +r_4576 (R)-2,3-Dihydroxy-3-methylbutanoate:NADP+ oxidoreductase (isomerizing) NADP(+)[c] + (R)-2,3-dihydroxy-3-methylbutanoate[c] <=> H+[c] + NADPH[c] + 3-hydroxy-3-methyl-2-oxobutanoate[c] Valine, leucine and isoleucine metabolism +r_4577 Dihydroxy-acid dehydratase, mitochondrial 3-methyl-2-oxobutanoate[c] + H2O[c] => 2,3-dihydroxy-3-methylbutanoate[c] Valine, leucine and isoleucine metabolism r_0096 +r_4578 Ketol-acid reductoisomerase, mitochondrial H+[c] + NADPH[c] + 2-acetyllactic acid[c] => NADP(+)[c] + (R)-2,3-dihydroxy-3-methylbutanoate[c] Valine, leucine and isoleucine metabolism r_0096 +r_4579 "pyruvate:pyruvate acetaldehydetransferase (decarboxylating); (S)-2-acetolactate pyruvate-lyase (carboxylating)" H+[c] + 2 pyruvate[c] => carbon dioxide[c] + (2S)-2-acetolactate[c] Valine, leucine and isoleucine metabolism +r_4580 (R)-2,3-dihydroxy-3-methylbutanoate:NADP+ oxidoreductase (isomerizing) NADP(+)[c] + (R)-2,3-dihydroxy-3-methylbutanoate[c] <=> H+[c] + NADPH[c] + (2S)-2-acetolactate[c] Valine, leucine and isoleucine metabolism r_0096 +r_4581 (2R,3S)-3-methylmalate:NAD+ oxidoreductase NAD[c] + (2R,3S)-3-methylmalate[c] => 2-oxobutanoate[c] + carbon dioxide[c] + NADH[c] Valine, leucine and isoleucine metabolism +r_4582 malate/beta-methylmalate synthase glyoxylate[c] + H2O[c] + propionyl-CoA[c] => coenzyme A[c] + H+[c] + (2R,3S)-3-methylmalate[c] Glyoxylate and dicarboxylate metabolism +r_4583 palmitoyl-CoA hydrolase H2O[c] + trans-2,cis-9-octadecadienoyl-CoA[c] => coenzyme A[c] + H+[c] + (9Z,12Z)-octadecadienoate[c] Biosynthesis of unsaturated fatty acids +r_4584 long-chain-fatty-acid---CoA ligase ATP[c] + coenzyme A[c] + (9Z,12Z)-octadecadienoate[c] => AMP[c] + diphosphate[c] + trans-2,cis-9-octadecadienoyl-CoA[c] Fatty acid biosynthesis +r_4585 a-galactosidase (stachyose) H2O[c] + stachyose[c] => D-galactose[c] + raffinose[c] Galactose metabolism +r_4586 stachyose synthase sucrose[c] + stachyose[c] => 2 raffinose[c] Galactose metabolism +r_4587 Ca(2+) transport H+[e] + Ca(2+)[e] <=> H+[c] + Ca(2+)[c] YOL122C Transport [c, e] +r_4588 chloride transport chloride[e] <=> chloride[c] YNL275W Transport [c, e] +r_4589 Cu2(+) transport H+[e] + Cu2(+)[e] <=> H+[c] + Cu2(+)[c] YOL122C Transport [c, e] +r_4590 Mn(2+) transport H+[e] + Mn(2+)[e] <=> H+[c] + Mn(2+)[c] YOL130W Transport [c, e] +r_4591 Zn(2+) transport H+[e] + Zn(2+)[e] <=> H+[c] + Zn(2+)[c] YGL255W or YLR130C Transport [c, e] +r_4592 Mg(2+) transport H+[e] + Mg(2+)[e] <=> H+[c] + Mg(2+)[c] YGR191W or YOL130W Transport [c, e] +r_4593 chloride exchange chloride[e] <=> Exchange reaction +r_4594 Cu2(+) exchange Cu2(+)[e] <=> Exchange reaction +r_4595 Mn(2+) exchange Mn(2+)[e] <=> Exchange reaction +r_4596 Zn(2+) exchange Zn(2+)[e] <=> Exchange reaction +r_4597 Mg(2+) exchange Mg(2+)[e] <=> Exchange reaction +r_4598 cofactor pseudoreaction 0.00019 coenzyme A[c] + 1e-05 FAD[c] + 0.00265 NAD[c] + 0.00015 NADH[c] + 0.00057 NADP(+)[c] + 0.0027 NADPH[c] + 0.00099 riboflavin[c] + 1.2e-06 TDP[c] + 6.34e-05 THF[c] + 1e-06 heme a[c] => cofactor[c] Growth +r_4599 ion pseudoreaction 3.04e-05 iron(2+)[c] + 0.00363 potassium[c] + 0.00397 sodium[c] + 0.02 sulphate[c] + 0.00129 chloride[c] + 0.00273 Mn(2+)[c] + 0.000748 Zn(2+)[c] + 0.000217 Ca(2+)[c] + 0.0012425 Mg(2+)[c] + 0.000659 Cu2(+)[c] => ion[c] Growth +r_4600 Ca(2+) exchange Ca(2+)[e] <=> Exchange reaction +r_4601 3-(4-hydroxyphenyl)pyruvate transport 3-(4-hydroxyphenyl)pyruvate[c] + H+[c] <=> 3-(4-hydroxyphenyl)pyruvate[p] + H+[p] Transport [c, p] +r_4602 acetate transport acetate[c] <=> acetate[er] Transport [c, er] +r_4603 ADP-ribose transport ADP-ribose[c] <=> ADP-ribose[n] Transport [c, n] +r_4604 farnesyl diphosphate transport farnesyl diphosphate[c] <=> farnesyl diphosphate[lp] Transport [c, lp] +r_4605 nicotinate transport H+[c] + nicotinate[c] <=> H+[m] + nicotinate[m] Transport [c, m] +r_4606 O-phosphoethanolamine transport H+[c] + O-phosphoethanolamine[c] <=> H+[er] + O-phosphoethanolamine[er] Transport [c, er] +r_4607 phosphate transport phosphate[c] <=> phosphate[g] Transport [c, g] +r_4608 propionyl-CoA transport ATP[c] + H2O[c] + propionyl-CoA[c] => ADP[m] + H+[m] + phosphate[m] + propionyl-CoA[m] Transport [c, m] +r_4609 UDP transport UDP[c] <=> UDP[g] Transport [c, g] +r_4610 UDP transport UDP[c] <=> UDP[n] Transport [c, n] +r_4611 UMP transport UMP[c] <=> UMP[g] Transport [c, g] +r_4612 TRX1 disulphide transport TRX1 disulphide[c] <=> TRX1 disulphide[n] Transport [c, n] +r_4613 oleate transport oleate[c] <=> oleate[m] Transport [c, m] +r_4614 (R)-acetoin transport (R)-acetoin[c] + H+[c] <=> H+[n] + (R)-acetoin[n] Transport [c, n] +r_4615 L-glutamine transport L-glutamine[c] <=> L-glutamine[m] Transport [c, m] +r_4616 UMP transport UMP[c] <=> UMP[er] Transport [c, er] +r_4617 S-adenosyl-L-methionine transport S-adenosyl-L-methionine[c] <=> S-adenosyl-L-methionine[n] Transport [c, n] +r_4618 glutathione transport glutathione[c] <=> glutathione[er] Transport [c, er] +r_4619 ATP transport ATP[c] + ADP[v] <=> ADP[c] + ATP[v] Transport [c, v] +r_4620 D-mannose 6-phosphate transport D-mannose 6-phosphate[c] <=> D-mannose 6-phosphate[v] Transport [c, v] +r_4621 O-acetyl-L-serine transport O-acetyl-L-serine[c] <=> O-acetyl-L-serine[m] Transport [c, m] +r_4622 hydrogen sulfide transport hydrogen sulfide[c] <=> hydrogen sulfide[m] Transport [c, m] +r_4623 L-cysteinylglycine transport H+[c] + L-cysteinylglycine[c] <=> H+[m] + L-cysteinylglycine[m] Transport [c, m] +r_4624 ATP transport ATP[c] + ADP[erm] <=> ADP[c] + ATP[erm] Transport [c, erm] +r_4625 thiosulfate transport thiosulfate[c] <=> thiosulfate[m] Transport [c, m] +r_4626 sulphite transport sulphite[c] <=> sulphite[m] Transport [c, m] +r_4627 UDP-D-glucose transport UDP-D-glucose[c] <=> UDP-D-glucose[er] Transport [c, er] +r_4628 UDP-N-acetyl-alpha-D-glucosamine transport UDP-N-acetyl-alpha-D-glucosamine[c] <=> UDP-N-acetyl-alpha-D-glucosamine[g] Transport [c, g] +r_4629 alcohol acyltransferase (hexanoyl-CoA) ethanol[m] + hexanoyl-CoA[m] <=> coenzyme A[m] + ethyl hexanoate[m] YBR177C or YPL095C Fatty acid ester pathway +r_4630 alcohol acyltransferase (octanoyl-CoA) ethanol[m] + octanoyl-CoA[m] <=> coenzyme A[m] + ethyl octanoate[m] YBR177C or YPL095C Fatty acid ester pathway +r_4631 alcohol acyltransferase (butyryl-CoA) ethanol[m] + butanoyl-CoA[m] <=> coenzyme A[m] + ethyl butanoate[m] YBR177C or YPL095C Fatty acid ester pathway +r_4632 alcohol acetyltransferase (hexanol) acetyl-CoA[m] + hexanol[m] <=> coenzyme A[m] + hexyl acetate[m] YGR177C or YOR377W or YGR015C Fatty acid ester pathway +r_4633 alcohol acyltransferase (decanoyl-CoA) ethanol[m] + decanoyl-CoA[m] <=> coenzyme A[m] + ethyl decanoate[m] YBR177C or YPL095C Fatty acid ester pathway +r_4634 ethyl hexanoate transport, mitochondrial ethyl hexanoate[m] <=> ethyl hexanoate[c] Transport [c, m] +r_4635 ethyl octanoate transport, mitochondrial ethyl octanoate[m] <=> ethyl octanoate[c] Transport [c, m] +r_4636 ethyl butanoate transport, mitochondrial ethyl butanoate[m] <=> ethyl butanoate[c] Transport [c, m] +r_4637 hexyl acetate transport, mitochondrial hexyl acetate[m] => hexyl acetate[c] Transport [c, m] +r_4638 ethyl decanoate transport, mitochondrial ethyl decanoate[m] => ethyl decanoate[c] Transport [c, m] +r_4639 ethyl hexanoate transport ethyl hexanoate[c] <=> ethyl hexanoate[e] Transport [c, e] +r_4640 ethyl octanoate transport ethyl octanoate[c] <=> ethyl octanoate[e] Transport [c, e] +r_4641 ethyl butanoate transport ethyl butanoate[c] <=> ethyl butanoate[e] Transport [c, e] +r_4642 hexyl acetate transport hexyl acetate[c] => hexyl acetate[e] Transport [c, e] +r_4643 ethyl decanoate transport ethyl decanoate[c] => ethyl decanoate[e] Transport [c, e] +r_4644 ethyl hexanoate exchange ethyl hexanoate[e] => Exchange reaction +r_4645 ethyl octanoate exchange ethyl octanoate[e] => Exchange reaction +r_4646 ethyl butanoate exchange ethyl butanoate[e] => Exchange reaction +r_4647 hexyl acetate exchange hexyl acetate[e] => Exchange reaction +r_4648 ethyl decanoate exchange ethyl decanoate[e] => Exchange reaction +r_4649 mitochondrial ethanol O-acetyltransferase acetyl-CoA[m] + ethanol[m] => coenzyme A[m] + ethyl acetate[m] YGR015C Fatty acid ester pathway +r_4650 ethyl acetate transport, mitochondrial ethyl acetate[m] => ethyl acetate[c] Transport [c, m] +r_4651 pyruvate decarboxylase (aldedyde-forming) 2-oxobutanoate[c] + H+[c] => carbon dioxide[c] + propanal[c] YGR087C or YLR044C or YLR134W Fatty acid ester pathway +r_4652 aldehyde dehydrogenase (1-propanol, NAD) H+[c] + NADH[c] + propanal[c] => NAD[c] + propanol[c] YBR145W or YDL168W or YOL086C Fatty acid ester pathway +r_4653 aldehyde dehydrogenase (1-propanol, NAD) H+[m] + NADH[m] + propanal[m] => NAD[m] + propanol[m] YGL256W or YMR083W Fatty acid ester pathway +r_4654 aldehyde dehydrogenase (1-propanol, NADP) H+[c] + NADPH[c] + propanal[c] => NADP(+)[c] + propanol[c] YCR105W or YDR368W or YMR318C Fatty acid ester pathway +r_4655 1-propyl alcohol transport, mitochondrial propanol[m] <=> propanol[c] Transport [c, m] +r_4656 propanal transport, cytosol propanal[c] <=> propanal[e] Transport [c, e] +r_4657 1-propyl alcohol transport, cytosol propanol[c] <=> propanol[e] Transport [c, e] +r_4658 propanal exchange propanal[e] => Exchange reaction +r_4659 propanol exchange propanol[e] => Exchange reaction +r_4660 2-oxo acid decarboxylase 4-methylthio-2-oxobutanoate[c] + H+[c] <=> carbon dioxide[c] + methional[c] YHR137W Fatty acid ester pathway +r_4661 aldehyde dehydrogenase (methionol, NAD) H+[c] + NADH[c] + methional[c] => NAD[c] + methionol[c] YBR145W or YDL168W or YOL086C Fatty acid ester pathway +r_4662 aldehyde dehydrogenase (methionol, NAD) H+[m] + NADH[m] + methional[m] => NAD[m] + methionol[m] YGL256W or YMR083W Fatty acid ester pathway +r_4663 aldehyde dehydrogenase (methionol, NADP) H+[c] + NADPH[c] + methional[c] => NADP(+)[c] + methionol[c] YCR105W or YDR368W or YMR318C Fatty acid ester pathway +r_4664 methionol transport, mitochondrial methionol[m] <=> methionol[c] Transport [c, m] +r_4665 methional transport, cytosol methional[c] <=> methional[e] Transport [c, e] +r_4666 methionol transport, cytosol methionol[c] <=> methionol[e] Transport [c, e] +r_4667 methional exchange methional[e] => Exchange reaction +r_4668 methionol exchange methionol[e] => Exchange reaction +r_4669 pyruvate decarboxylase (hydroxy-phenyl) 3-(4-hydroxyphenyl)pyruvate[c] + H+[c] => carbon dioxide[c] + (4-hydroxyphenyl)acetaldehyde[c] YGR087C or YLR044C or YLR134W Fatty acid ester pathway +r_4670 aldehyde dehydrogenase (tyrosol, NAD) H+[c] + NADH[c] + (4-hydroxyphenyl)acetaldehyde[c] => NAD[c] + tyrosol[c] YBR145W or YDL168W or YOL086C Fatty acid ester pathway +r_4671 aldehyde dehydrogenase (tyrosol, NAD) H+[m] + NADH[m] + (4-hydroxyphenyl)acetaldehyde[m] => NAD[m] + tyrosol[m] YGL256W or YMR083W Fatty acid ester pathway +r_4672 aldehyde dehydrogenase (tyrosol, NADP) H+[c] + NADPH[c] + (4-hydroxyphenyl)acetaldehyde[c] => NADP(+)[c] + tyrosol[c] YCR105W or YDR368W or YMR318C Fatty acid ester pathway +r_4673 tyrosol transport, mitochondrial tyrosol[m] <=> tyrosol[c] Transport [c, m] +r_4674 (4-hydroxyphenyl)acetaldehyde transport, cytosol (4-hydroxyphenyl)acetaldehyde[c] <=> (4-hydroxyphenyl)acetaldehyde[e] Transport [c, e] +r_4675 tyrosol transport, cytosol tyrosol[c] <=> tyrosol[e] Transport [c, e] +r_4676 (4-hydroxyphenyl)acetaldehyde exchange (4-hydroxyphenyl)acetaldehyde[e] => Exchange reaction +r_4677 tyrosol exchange tyrosol[e] => Exchange reaction +r_4678 aldehyde dehydrogenase H2O[c] + NAD[c] + propanal[c] <=> H+[c] + NADH[c] + propionate[c] YMR170C or YMR169C or YOR374W Fatty acid ester pathway +r_4679 short-chain-fatty-acid-CoA ligase (propionate) ATP[p] + coenzyme A[p] + propionate[p] <=> AMP[p] + diphosphate[p] + propionyl-CoA[p] YOR317W or YER015W or YIL009W or YMR246W Fatty acid ester pathway +r_4680 alcohol acyltransferase (propionyl-CoA) ethanol[m] + propionyl-CoA[m] <=> coenzyme A[m] + ethyl propionate[m] YBR177C or YPL095C Fatty acid ester pathway +r_4681 propionyl-CoA transport, mitochondrial propionyl-CoA[p] <=> propionyl-CoA[m] Transport [p, m] +r_4682 butyryl-CoA transport, mitochondrial butanoyl-CoA[p] <=> butanoyl-CoA[m] Transport [p, m] +r_4683 hexanoyl-CoA transport, mitochondrial hexanoyl-CoA[p] <=> hexanoyl-CoA[m] Transport [p, m] +r_4684 octanoyl-CoA transport, mitochondrial octanoyl-CoA[p] <=> octanoyl-CoA[m] Transport [p, m] +r_4685 decanoyl-CoA transport, mitochondrial decanoyl-CoA[p] <=> decanoyl-CoA[m] Transport [p, m] +r_4686 propionate transport, cytosol propionate[p] <=> propionate[c] Transport [c, p] +r_4687 alcohol acetyltransferase (tyrosol) acetyl-CoA[c] + tyrosol[c] => coenzyme A[c] + tyrosyl acetate[c] YGR177C or YOR377W or YGR015C Fatty acid ester pathway +r_4688 tyrosyl acetate transport tyrosyl acetate[c] => tyrosyl acetate[e] Transport [c, e] +r_4689 tyrosyl acetate exchange tyrosyl acetate[e] => Exchange reaction +r_4690 alcohol acetyltransferase (methionol) acetyl-CoA[c] + methionol[c] => coenzyme A[c] + methionyl acetate[c] YGR177C or YOR377W or YGR015C Fatty acid ester pathway +r_4691 methionyl acetate transport methionyl acetate[c] => methionyl acetate[e] Transport [c, e] +r_4692 methionyl acetate exchange methionyl acetate[e] => Exchange reaction +r_4693 alcohol acetyltransferase (propanol) acetyl-CoA[c] + propanol[c] => coenzyme A[c] + propyl acetate[c] YGR177C or YOR377W or YGR015C Fatty acid ester pathway +r_4694 propyl acetate transport propyl acetate[c] => propyl acetate[e] Transport [c, e] +r_4695 propyl acetate exchange propyl acetate[e] => Exchange reaction +r_4697 ethyl propionate transport, mitochondrial ethyl propionate[m] <=> ethyl propionate[c] Transport [c, m] +r_4698 ethyl propionate transport ethyl propionate[c] => ethyl propionate[e] Transport [c, e] +r_4699 ethyl propionate exchange ethyl propionate[e] => Exchange reaction diff --git a/data/physiology/README.md b/data/physiology/README.md index b9d9c5d1..aa995af0 100644 --- a/data/physiology/README.md +++ b/data/physiology/README.md @@ -1,3 +1,5 @@ ## Physiology Data on yeast growth under different conditions, biomass composition, gene essentiality experiments, etc. + +Data files that are only used once, for instance containing a list of new reactions to be added to the model, should instead be stored in a dedicated folder in ../modelCuration. diff --git a/history.md b/history.md deleted file mode 100644 index 7053126f..00000000 --- a/history.md +++ /dev/null @@ -1,249 +0,0 @@ -# History - -### yeast 8.6.0: -- Fixes: - - Closes #265: Make `r_0446` (formate-tetrahydrofolate ligase) irreversible, to prevent non-zero flux through TCA cycle. (PR #290) -- Features: - - Add pathways responsible for the formation of hydrogen sulfide as well as other volatile sulfur compounds during fermentation (PR #300) - - Closes #302: Simplify model curation with `curateRxnsGenesMets` function (PR #300) - - Remove COBRA Toolbox and MATLAB-git dependencies for the MATLAB-based curation pipeline (PR #303) - - Closes #308: Distribute `yeast-GEM.mat` in RAVEN's format, to include `grRules` and `metComps` fields (PR #301) -- Refactor: - - Change format of `yeast-GEM.txt` file to include metabolite names and compartments, instead of metabolite identifiers, to simplify `diff`-ing (metabolite identifiers are already trackable in the `yml`-file) (PR #312) - -### yeast 8.5.0: -- Features: - - Set up memote as GitHub Action for pull requests (PR #162) - - Moved old subSystems to reaction annotations (in `rxnMiriams` or `rxnKEGGpathways`) (PR #253) -- Fixes: - - Combine glycolysis + gluconeogenesis as single KEGG pathway annotations (PR #251). - - Closes #252: Correct grRule of r_4590 (PR #255). - - Closes #254: Corrects name of s_1218 (PR #255). - - `saveYeastModel.m` now correctly handles Unicode characters (PR #255). - - Closes #238: Correct indentation of `yeastGEM.yml` (PR #236 and #255). -- Chore: - - Update dependencies in `*requirements.txt` (PR #256). - - Minor changes in model file formatting due to updates in COBRA+RAVEN toolboxes (PR #253). -- Refactor: - - Closes #232: Follow `standard-GEM` specifications (PR #257). - - Closes #258: Rename git branches `master` and `devel` to `main` and `develop` (PR #261). - -### yeast 8.4.2: -* Features: - * `saveYeastModel.m` now checks if the model can grow and, based on the `allowNoGrowth` flag, returns either warnings or errors if not (PR #244). - * Added several fatty acid ester producing reactions to the model, for improved simulation of alcoholic fermentation conditions (PRs #190 and #248). -* Fixes: - * Closes #242: Fixed a bug that prevented the model from growing (PR #243). - * Corrected directionality of 23 reactions and removed a generic reaction (PR #228). - -### yeast 8.4.1: -* Features: - * Switched to `pip-tools` for managing python dependencies, distinguishing between user requirements `/requirements/requirements.txt` and developer requirements `/requirements/dev-requirements.txt` (PR #235). -* Fixes: - * Closes #201: Changed generic protein name to avoid confusion (PR #237). - * Closes #205: Finished correcting reactions' stoichiometry based on KEGG data (PR #237). - * Closes #215: Corrected wrong gene rule in reaction (PR #237). - * Closes #225: Moved MNX rxn ids from notes to the proper annotation field (PR #226). -* Documentation: - * Closes #223: Clarified releasing steps, including authorship criteria for Zenodo releases, in contributing guidelines (PR #233). - * Closes #227: Removed authorships/dates from all scripts, as it is redundant information (PR #230). - * Added admin guidelines for managing python dependencies (PR #235). - * Included links for model visualization in README file (PR #240). - -### yeast 8.4.0: -* Features: - * New functions `mapKEGGID.m ` and `mapMNXMID.m` for adding ids in model. Used them to add missing KEGG and MetaNetX ids for both metabolites and reactions (PR #220). - * Solves #197: Added missing MetaNetX ids using KEGG ids and ChEBI ids (PR #220). - * Added BiGG ids for all matched metabolites/reactions using MetaNetX + manual curation, together with lists containing new BiGG ids for the unmatched ones (PR #188). - * New functions `read_yeast_model` and `write_yeast_model` for easier usage in python (PR #224). - * Solves #172: Model can now be loaded with BiGG ids as main ids, for better compliance with cobrapy (PR #224). -* Fixes: - * Solves #102: Every component of the model is now preserved when the model is opened with cobrapy, including gene names (PR #216). - * Manual curation of MetaNetX, KEGG and ChEBI ids for metabolites/reactions (PRs #188 and #220). - * Solves #187: Removed some duplicate reactions in the model (PR #188). - * Mass/charge balanced most unbalanced reactions in model using `checkSmatrixMNX.m`, bringing the number down to 17 reactions (PR #222). -* Others: - * Configured repo to ensure that files always use `LF` as EOL character (PR #221). - * Gene SBO terms are now recorded, after update in COBRA toolbox (PR #188). - -### yeast 8.3.5: -* Fixes: - * Closes #129: Removed non-S288C genes (PR #211). - * Closes #198: Fixes function for converting model to anaerobic (PR #199). -* Tests: - * Added growth tests for carbon & nitrogen limitation (#199). - * Added test for computing gene essentiality (PR #200). -* Documentation/Others: - * Clarified with README's the purpose of each script/data folder (#209). - * Closes #206: Updated citation guidelines (PR #210). - * Updated contribution guidelines + issue/PR templates (PR #210). - * Created folders with deprecated scripts (PR #209). - -### yeast 8.3.4: -* Features: - * Fixes #171: Added 101 GPR rules to transport rxns according to TCDB database (PR #178). - * Added 18 met formulas from manual search (PR #155). - * Performed gap-filling for connecting 29 dead-end mets, by adding 28 transport rxns (PR #185). Added documentation to the gap-filling functions in PR #195. -* Fixes: - * Corrected typo in gene ID (PR #186). - -### yeast 8.3.3: -* Features: - * Fixes #107: Two new pseudoreactions (`cofactor pseudoreaction` and `ion pseudoreaction`) added to the model as extra requirements to the biomass pseudoreaction (PRs #174 & #183). -* Fixes: - * `addSBOterms.m` adapted to identify new pseudoreactions (PR #180). - * Removed non-compliant symbol from a reaction name to avoid parsing errors (PR #179). -* Documentation: - * Model keywords modified to comply with the sysbio rulebook (PR #173). - * Added citation guidelines (PR #181). - -### yeast 8.3.2: -* Features: - * Fixes #154: MetaNetX IDs added from the yeast7.6 [MetaNetX](https://www.metanetx.org) model & from existing ChEBI and KEGG IDs in the model (PR #167). - * Introduced contributing guidelines + code of conduct (PR #175). -* Fixes: - * Fixes #161: Added as `rxnNotes` and `metNotes` the corresponding PR number (#112, #142, #149 or #156) in which each rxn and met was introduced (PR #170). - * Fixes #169: Compartment error for `r_4238` (PR #170). - * Corrected confidence score of rxns from PR #142 (PR #170). - -### yeast 8.3.1: -* Features: - * Added 21 reactions & 14 metabolites based on metabolomics data (PR #156). - * Added metadata to the excel version of the model (PR #163). - * Added `ComplementaryData/physiology` with biological data of yeast (PR #159). -* Fixes/Others: - * Fixed bug that underestimated the biomass content (PR #159). - * Fitted GAM to chemostat data (PR #159). - -### yeast 8.3.0: -* Features: - * Added 225 new reactions and 148 new metabolites, based on growth data from a Biolog substrate usage experiment on carbon, nitrogen, sulfur and phosphorus substrates (PR #149). -* Fixes/Others: - * Removed verbose details from `README.md` (PR #150). - * Updated RAVEN, which added extra annotation to the `.yml` file (PR #151). - * Minor changes to `saveYeastModel.m` (PR #152). - * Model is now stored simulating minimal media conditions (PR #157). - -### yeast 8.2.0: -* Features: - * Fixes #38: Added 183 new reactions, 277 new metabolites and 163 new genes based on the latest genome annotation in SGD, uniprot, KEGG, Biocyc & Reactome (PR #142). -* Fixes: - * `grRules` deleted from pseudoreactions, removing with this 49 genes (PR #145). -* Chores: - * Updated COBRA, which changed the number of decimals in some stoichiometric coefficients in `.txt` (PR #143) - -### yeast 8.1.3: -* Features: - * Added SBO terms for all metabolites and reactions, based on an automatic script now part of `saveYeastModel.m` (PR #132). - * `increaseVersion.m` now avoids conflicts between `devel` and `master` by erroring before releasing and guiding the admin to change first `devel` (PR #133). - * Website now available in `gh-pages` branch: http://sysbiochalmers.github.io/yeast-GEM/ -* Fixes: - * Standardize naming of pseudo-metabolites "lipid backbone" & "lipid chain" (PR #130). -* Chores: - * Updated COBRA, which swapped around the order of the `bqbiol:is` and `bqbiol:isDescribedBy` qualifiers in the `.xml` file (PR #131). - -### yeast 8.1.2: -* New features: - * `saveYeastModel.m` now checks if the model is a valid SBML structure; if it isn't it will error (PR #126). - * Date + model size in `README.md` updates automatically when saving the model (PR #123). - * Added `modelName` and `modelID`; the latter which will now store the version number (PR #127). -* Fixes: - * Fixes #60: New GPR relations for existing reactions were added according to new annotation from 5 different databases (PR #124). - * Various fixes in `README.md` (PR #123). - -### yeast 8.1.1: -* Fixes: - * Fixes #96: regardless if the model is saved with a windows or a MAC machine, the `.xml` file is now stored with the same scientific format. - * Fixes #108: No CHEBI or KEGG ids are now shared by different metabolites. Also, updated the metabolites that were skipped in the previous manual curation (PR #74). - * Remade function for defining confidence scores, which fixed 38 scores in `rxnConfidenceScores` (most of them from pseudoreactions). - * `loadYeastModel` and `saveYeastModel` were improved to allow their use also when outside of the actual folder. - -### yeast 8.1.0: -* New features: - * SLIME reactions added to the model using [SLIMEr](https://github.com/SysBioChalmers/SLIMEr), to properly account for constraints on lipid metabolism (fixes #21): - * SLIME rxns replace old ISA rxns for lumping lipids. They create 2 types of lipid pseudometabolites: backbones and acyl chains. - * There are now 3 lipid pseudoreactions: 1 constrains backbones, 1 constrains acyl chains, 1 merges both. -* Fixes: - * All metabolite formulas made compliant with SBML (fixes #19). Model is now a valid SBML object. - * Biomass composition was rescaled to experimental data from [Lahtvee et al. 2017](https://www.sciencedirect.com/science/article/pii/S2405471217300881), including protein and RNA content, trehalose and glycogen concentrations, lipid profile and FAME data. Biomass was fitted to add up to 1 g/gDW by rescaling total carbohydrate content (unmeasured). -* Refactoring: - * Organized all files in `ComplementaryData` - -### yeast 8.0.2: -* New features: - * Model can now be used with cobrapy by running `loadYeastModel.py` - * `loadYeastModel.m` now adds the `rxnGeneMat` field to the model -* Refactoring: - * Moved `pmids` of model from `rxnNotes` to `rxnReferences` (COBRA-compliant) - * `yeastGEM.yml` and `dependencies.txt` are now updated by RAVEN (a few dependencies added) - * Moved `boundaryMets.txt` and `dependencies.txt` to the `ModelFiles` folder -* Documentation: - * Added badges and adapted README ro reflect new features - -### yeast 8.0.1: -* `.yml` format included for easier visualization of model changes -* Empty notes removed from model -* Issue and PR templates included -* `README.md` updated to comply with new repo's name - -### yeast 8.0.0: -First version of the yeast8 model, to separate it from previous versions: - -* Manual curation project: - * All metabolite information manually curated (names, charges, kegg IDs, chebi IDs) - * Reaction gene rules updated with curation from [the iSce926 model](http://www.maranasgroup.com/submission_models/iSce926.htm). 13 genes added in this process -* Format changes: - * Folder `ComplementaryData` introduced - * All data is stored in `.tsv` format now (can be navigated in Github) - * Releases now come in `.xlsx` as well -* Other new features: - * Added `loadYeastModel.m` - * A much smarter `increaseVersion.m` - * Lots of refactoring - -### yeast 7.8.3: -* curated tRNA's formulas -* started tracking COBRA and RAVEN versions -* dropped SBML toolbox as requirement -* reorganized `complementaryScripts` -* switched to a CC-BY-4.0 license - -### yeast 7.8.2: -* fixed subSystems bug: now they are saved as individual groups -* solved inter-OS issues -* remade license to follow GitHub format -* added `history.md` and made it a requirement to update when increasing version - -### yeast 7.8.1: -* started following dependencies -* started keeping track of the version in the repo (`version.txt`) -* included `.gitignore` -* dropped `.mat` storage for `devel` + feature branches (but kept it in `master`) - -### yeast 7.8.0: -* Added information: - * `metFormulas` added for all lipids - * `rxnKEGGID` added from old version - * `rxnNotes` enriched with Pubmed ids (`pmid`) from old version - * `rxnConfidenceScores` added based on automatic script (available in [`ComplementaryScripts`](https://github.com/SysBioChalmers/yeast-GEM/blob/master/ComplementaryScripts)) -* Format changes: - * Biomass clustered by 5 main groups: protein, carbohydrate, lipid, RNA and DNA - -### yeast 7.7.0: -* Format changes: - * FBCv2 compliant - * Compatible with latest COBRA and RAVEN parsers - * Created main structure of repository -* Added information: - * `geneNames` added to genes based on [KEGG](http://www.genome.jp/kegg/) data - * `subSystems` and `rxnECnumbers` added to reactions based on [KEGG](http://www.genome.jp/kegg/) & [Swissprot](http://www.uniprot.org/uniprot/?query=*&fil=organism%3A%22Saccharomyces+cerevisiae+%28strain+ATCC+204508+%2F+S288c%29+%28Baker%27s+yeast%29+%5B559292%5D%22+AND+reviewed%3Ayes) data - * Boundary metabolites tracked (available in [`ComplementaryScripts`](https://github.com/SysBioChalmers/yeast-GEM/blob/master/ComplementaryScripts)) -* Simulation improvements: - * Glucan composition fixed in biomass pseudo-rxn - * Proton balance in membrane restored - * Ox.Pho. stoichiometry fixed - * NGAM rxn introduced - * GAM in biomass pseudo-rxn fixed and refitted to chemostat data - -### yeast 7.6.0: -First release of the yeast model in GitHub, identical to the last model available at https://sourceforge.net/projects/yeast/ \ No newline at end of file diff --git a/model/dependencies.txt b/model/dependencies.txt old mode 100755 new mode 100644 index 18003ac1..11e5eba1 --- a/model/dependencies.txt +++ b/model/dependencies.txt @@ -1,4 +1,4 @@ -MATLAB 9.10.0.1602886 (R2021a) +MATLAB 9.10.0.1851785 (R2021a) Update 6 libSBML 5.19.0 -RAVEN_toolbox 2.7.1 +RAVEN_toolbox commit cef4a35 COBRA_toolbox unknown diff --git a/model/yeast-GEM.mat b/model/yeast-GEM.mat deleted file mode 100644 index f7e5e0eb..00000000 Binary files a/model/yeast-GEM.mat and /dev/null differ diff --git a/model/yeast-GEM.txt b/model/yeast-GEM.txt index 69e7fa9f..259abdad 100755 --- a/model/yeast-GEM.txt +++ b/model/yeast-GEM.txt @@ -3,7 +3,7 @@ r_0001 (R)-lactate[c] + 2 ferricytochrome c[m] => 2 ferrocytochrome c[m] + pyruv r_0002 (R)-lactate[m] + 2 ferricytochrome c[m] => 2 ferrocytochrome c[m] + pyruvate[m] (YDL178W and YEL039C) or (YDL178W and YJR048W) 0.00 1000.00 0.00 r_0003 (R,R)-2,3-butanediol[c] + NAD[c] <=> (R)-acetoin[c] + H+[c] + NADH[c] YAL060W -1000.00 1000.00 0.00 r_0004 (S)-lactate[c] + 2 ferricytochrome c[m] => 2 ferrocytochrome c[m] + pyruvate[c] (YEL039C and YML054C) or (YJR048W and YML054C) 0.00 1000.00 0.00 -r_0005 UDP-D-glucose[c] => (1->3)-beta-D-glucan[ce] + H+[c] + UDP[c] YGR032W or YMR306W or (YLR342W and YCR034W) 0.00 1000.00 0.00 +r_0005 UDP-D-glucose[c] => (1->3)-beta-D-glucan[ce] + H+[c] + UDP[c] (YPR165W and YLR342W) or (YPR165W and YGR032W) or (YPR165W and YMR306W) 0.00 1000.00 0.00 r_0006 UDP-D-glucose[c] => (1->6)-beta-D-glucan[ce] + H+[c] + UDP[c] YGR143W or YPR159W 0.00 1000.00 0.00 r_0007 1-(5-phospho-D-ribosyl)-5-[(5-phospho-D-ribosylamino)methylideneamino]imidazole-4-carboxamide[c] => 5-[(5-phospho-1-deoxy-D-ribulos-1-ylamino)methylideneamino]-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide[c] YIL020C 0.00 1000.00 0.00 r_0012 1-pyrroline-5-carboxylate[m] + 2 H2O[m] + NAD[m] => H+[m] + L-glutamate[m] + NADH[m] YHR037W 0.00 1000.00 0.00 @@ -15,8 +15,8 @@ r_0017 2-amino-6-(hydroxymethyl)-7,8-dihydropteridin-4-ol[m] + ATP[m] => (2-amin r_0018 2-oxoadipic acid[c] + L-glutamate[c] <=> 2-oxoglutarate[c] + L-2-aminoadipate[c] YER152C or YGL202W or YJL060W -1000.00 1000.00 0.00 r_0019 2-dehydropantoate[c] + H+[c] + NADPH[c] => (R)-pantoate[c] + NADP(+)[c] YHR063C 0.00 1000.00 0.00 r_0020 D-erythrose 4-phosphate[m] + H2O[m] + phosphoenolpyruvate[m] => 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonic acid[m] + phosphate[m] YDR035W or YBR249C 0.00 1000.00 0.00 -r_0021 2-hexaprenyl-6-methoxy-1,4-benzoquinone[m] + S-adenosyl-L-methionine[m] => 2-hexaprenyl-6-methoxy-3-methyl-1,4-benzoquinone[m] + H+[m] + S-adenosyl-L-homocysteine[m] YDR204W and YGL119W and YGR255C and YLR201C and YML110C and YOL096C and YOR125C 0.00 1000.00 0.00 -r_0022 2-hexaprenyl-6-methoxyphenol[m] + oxygen[m] => 2-hexaprenyl-6-methoxy-1,4-benzoquinone[m] + H2O[m] YDR204W and YGL119W and YGR255C and YLR201C and YML110C and YOL096C and YOR125C 0.00 1000.00 0.00 +r_0021 2-hexaprenyl-6-methoxy-1,4-benzoquinone[m] + S-adenosyl-L-methionine[m] => 2-hexaprenyl-6-methoxy-3-methyl-1,4-benzoquinone[m] + H+[m] + S-adenosyl-L-homocysteine[m] YDR204W and YGR255C and YLR201C and YML110C and YOL096C and YOR125C 0.00 1000.00 0.00 +r_0022 2-hexaprenyl-6-methoxyphenol[m] + oxygen[m] => 2-hexaprenyl-6-methoxy-1,4-benzoquinone[m] + H2O[m] YDR204W and YGR255C and YLR201C and YML110C and YOL096C and YOR125C 0.00 1000.00 0.00 r_0023 2-isopropylmaleic acid[c] + H2O[c] <=> 2-isopropylmalate[c] YGL009C -1000.00 1000.00 0.00 r_0024 3-methyl-2-oxobutanoate[c] + acetyl-CoA[c] + H2O[c] => 2-isopropylmalate[c] + coenzyme A[c] + H+[c] YNL104C or YOR108W 0.00 1000.00 0.00 r_0025 3-methyl-2-oxobutanoate[m] + acetyl-CoA[m] + H2O[m] => 2-isopropylmalate[m] + coenzyme A[m] + H+[m] YNL104C 0.00 1000.00 0.00 @@ -230,10 +230,10 @@ r_0259 ceramide-1 (C24)[er] + H+[er] + NADPH[er] + oxygen[er] => ceramide-2 (C24 r_0260 ceramide-1 (C24)[er] + H+[er] + NADPH[er] + oxygen[er] => ceramide-2' (C24)[er] + H2O[er] + NADP(+)[er] YMR272C 0.00 1000.00 0.00 r_0261 ceramide-1 (C26)[er] + H+[er] + NADPH[er] + oxygen[er] => ceramide-2 (C26)[er] + H2O[er] + NADP(+)[er] YDR297W 0.00 1000.00 0.00 r_0262 ceramide-1 (C26)[er] + H+[er] + NADPH[er] + oxygen[er] => ceramide-2' (C26)[er] + H2O[er] + NADP(+)[er] YMR272C 0.00 1000.00 0.00 -r_0263 sphinganine[er] + tetracosanoyl-CoA[er] => ceramide-1 (C24)[er] + coenzyme A[er] + H+[er] (YHL003C and YMR298W) or (YKL008C and YMR298W) 0.00 1000.00 0.00 -r_0264 hexacosanoyl-CoA[er] + sphinganine[er] => ceramide-1 (C26)[er] + coenzyme A[er] + H+[er] (YHL003C and YMR298W) or (YKL008C and YMR298W) 0.00 1000.00 0.00 -r_0265 phytosphingosine[er] + tetracosanoyl-CoA[er] => ceramide-2 (C24)[er] + coenzyme A[er] + H+[er] (YHL003C and YMR298W) or (YKL008C and YMR298W) 0.00 1000.00 0.00 -r_0266 hexacosanoyl-CoA[er] + phytosphingosine[er] => ceramide-2 (C26)[er] + coenzyme A[er] + H+[er] (YHL003C and YMR298W) or (YKL008C and YMR298W) 0.00 1000.00 0.00 +r_0263 sphinganine[er] + tetracosanoyl-CoA[er] => ceramide-1 (C24)[er] + coenzyme A[er] + H+[er] YKL008C and YHL003C and YMR298W 0.00 1000.00 0.00 +r_0264 hexacosanoyl-CoA[er] + sphinganine[er] => ceramide-1 (C26)[er] + coenzyme A[er] + H+[er] YKL008C and YHL003C and YMR298W 0.00 1000.00 0.00 +r_0265 phytosphingosine[er] + tetracosanoyl-CoA[er] => ceramide-2 (C24)[er] + coenzyme A[er] + H+[er] YKL008C and YHL003C and YMR298W 0.00 1000.00 0.00 +r_0266 hexacosanoyl-CoA[er] + phytosphingosine[er] => ceramide-2 (C26)[er] + coenzyme A[er] + H+[er] YKL008C and YHL003C and YMR298W 0.00 1000.00 0.00 r_0267 ceramide-2 (C24)[er] + H+[er] + NADPH[er] + oxygen[er] => ceramide-3 (C24)[er] + H2O[er] + NADP(+)[er] YMR272C 0.00 1000.00 0.00 r_0268 ceramide-2 (C26)[er] + H+[er] + NADPH[er] + oxygen[er] => ceramide-3 (C26)[er] + H2O[er] + NADP(+)[er] YMR272C 0.00 1000.00 0.00 r_0269 ceramide-3 (C24)[er] + H+[er] + NADPH[er] + oxygen[er] => ceramide-4 (C24)[er] + H2O[er] + NADP(+)[er] YMR272C 0.00 1000.00 0.00 @@ -415,7 +415,7 @@ r_0528 ATP[c] + GMP[c] => ADP[c] + GDP[c] YDR454C 0.00 1000.00 0.00 r_0529 dATP[c] + GMP[c] <=> dADP[c] + GDP[c] YDR454C -1000.00 1000.00 0.00 r_0530 heme o[m] + NADH[m] + oxygen[m] => H2O[m] + heme a[m] + NAD[m] YER141W or (YDR376W and YPL252C) 0.00 1000.00 0.00 r_0531 farnesyl diphosphate[m] + ferroheme b[m] + H2O[m] => diphosphate[m] + heme o[m] YPL172C 0.00 1000.00 0.00 -r_0532 2-hexaprenyl-5-hydroxy-6-methoxy-3-methyl-1,4-benzoquinone[m] + H+[m] + S-adenosyl-L-methionine[m] => S-adenosyl-L-homocysteine[m] + ubiquinol-6[m] YDR204W and YGL119W and YGR255C and YLR201C and YML110C and YOL096C and YOR125C 0.00 1000.00 0.00 +r_0532 2-hexaprenyl-5-hydroxy-6-methoxy-3-methyl-1,4-benzoquinone[m] + H+[m] + S-adenosyl-L-methionine[m] => S-adenosyl-L-homocysteine[m] + ubiquinol-6[m] YDR204W and YGR255C and YLR201C and YML110C and YOL096C and YOR125C 0.00 1000.00 0.00 r_0533 ATP[c] + D-fructose[c] => ADP[c] + D-fructose 6-phosphate[c] + H+[c] YLR446W or YFR053C or YGL253W 0.00 1000.00 0.00 r_0534 ATP[c] + D-glucose[c] => ADP[c] + D-glucose 6-phosphate[c] + H+[c] YLR446W or YCL040W or YFR053C or YGL253W or YDR516C 0.00 1000.00 0.00 r_0535 ATP[c] + D-mannose[c] => ADP[c] + D-mannose 6-phosphate[c] + H+[c] YLR446W or YFR053C or YGL253W 0.00 1000.00 0.00 @@ -661,8 +661,8 @@ r_0818 L-glutamate[m] + N(2)-acetyl-L-ornithine[m] => N-acetyl-L-glutamate[m] + r_0819 2-oxoglutarate[c] + ornithine[c] => L-glutamate[c] + L-glutamic 5-semialdehyde[c] YLR438W 0.00 1000.00 0.00 r_0820 diphosphate[c] + orotidine 5'-(dihydrogen phosphate)[c] <=> orotate[c] + PRPP[c] YML106W or YMR271C -1000.00 1000.00 0.00 r_0821 H+[c] + orotidine 5'-(dihydrogen phosphate)[c] => carbon dioxide[c] + UMP[c] YEL021W 0.00 1000.00 0.00 -r_0831 coenzyme A[m] + S(8)-succinyldihydrolipoamide[m] => dihydrolipoamide[m] + succinyl-CoA[m] YDR148C and YFL018C and YIL125W 0.00 1000.00 0.00 -r_0832 2-oxoglutarate[m] + H+[m] + lipoamide[m] => carbon dioxide[m] + S(8)-succinyldihydrolipoamide[m] YDR148C and YFL018C and YIL125W 0.00 1000.00 0.00 +r_0831 coenzyme A[m] + S(8)-succinyldihydrolipoamide[m] => dihydrolipoamide[m] + succinyl-CoA[m] (YDR148C and YFL018C and YIL125W and YFR049W) or (YDR148C and YFL018C and YIL125W) 0.00 1000.00 0.00 +r_0832 2-oxoglutarate[m] + H+[m] + lipoamide[m] => carbon dioxide[m] + S(8)-succinyldihydrolipoamide[m] (YDR148C and YFL018C and YIL125W and YFR049W) or (YDR148C and YFL018C and YIL125W) 0.00 1000.00 0.00 r_0841 ATP[c] + H+[c] + pantetheine 4'-phosphate[c] => 3'-dephospho-CoA[c] + diphosphate[c] YGR277C 0.00 1000.00 0.00 r_0842 (R)-pantothenate[c] + ATP[c] => (R)-4'-phosphopantothenic acid[c] + ADP[c] + H+[c] YDR531W 0.00 1000.00 0.00 r_0843 (R)-pantoate[c] + ATP[c] + beta-alanine[c] => (R)-pantothenate[c] + AMP[c] + diphosphate[c] + H+[c] YIL145C 0.00 1000.00 0.00 @@ -681,8 +681,8 @@ r_0882 N-acetyl-D-glucosamine 6-phosphate[c] <=> N-acetyl-alpha-D-glucosamine 1- r_0883 3'-phospho-5'-adenylyl sulfate[c] + TRX1[c] => adenosine 3',5'-bismonophosphate[c] + H+[c] + sulphite[c] + TRX1 disulphide[c] (YGR209C and YPR167C) or (YLR043C and YPR167C) 0.00 1000.00 0.00 r_0884 ATP[c] + oxaloacetate[c] => ADP[c] + carbon dioxide[c] + phosphoenolpyruvate[c] YKR097W 0.00 1000.00 0.00 r_0885 CTP[c] + H+[c] + O-phosphoethanolamine[c] => CDP-ethanolamine[c] + diphosphate[c] YGR007W 0.00 1000.00 0.00 -r_0886 ATP[c] + D-fructose 6-phosphate[c] => ADP[c] + D-fructose 1,6-bisphosphate[c] + H+[c] YMR205C or (YGR240C and YMR205C) 0.00 1000.00 0.00 -r_0887 ATP[c] + sedoheptulose 7-phosphate[c] => ADP[c] + H+[c] + sedoheptulose 1,7-bisphosphate[c] YMR205C or (YGR240C and YMR205C) 0.00 1000.00 0.00 +r_0886 ATP[c] + D-fructose 6-phosphate[c] => ADP[c] + D-fructose 1,6-bisphosphate[c] + H+[c] YGR240C and YMR205C 0.00 1000.00 0.00 +r_0887 ATP[c] + sedoheptulose 7-phosphate[c] => ADP[c] + H+[c] + sedoheptulose 1,7-bisphosphate[c] YGR240C and YMR205C 0.00 1000.00 0.00 r_0888 D-glucose 6-phosphate[c] <=> D-glucose 1-phosphate[c] YMR105C or YKL127W -1000.00 1000.00 0.00 r_0889 6-phospho-D-gluconate[c] + NADP(+)[c] => carbon dioxide[c] + D-ribulose 5-phosphate[c] + NADPH[c] YGR256W or YHR183W 0.00 1000.00 0.00 r_0890 alpha-D-glucosamine 1-phosphate[c] <=> alpha-D-glucosamine 6-phosphate[c] YEL058W -1000.00 1000.00 0.00 @@ -693,7 +693,7 @@ r_0902 D-mannose 1-phosphate[c] <=> D-mannose 6-phosphate[c] YFL045C -1000.00 1 r_0903 4-amino-2-methyl-5-phosphomethylpyrimidine[c] + ATP[c] => 4-amino-2-methyl-5-diphosphomethylpyrimidine[c] + ADP[c] YOL055C or YPL258C or YPR121W 0.00 1000.00 0.00 r_0904 (R)-5-phosphomevalonic acid[c] + ATP[c] => (R)-5-diphosphomevalonic acid[c] + ADP[c] YMR220W 0.00 1000.00 0.00 r_0905 (R)-4'-phosphopantothenic acid[c] + CTP[c] + L-cysteine[c] => CMP[c] + diphosphate[c] + H+[c] + N-[(R)-4-phosphonopantothenoyl]-L-cysteine[c] YIL083C 0.00 1000.00 0.00 -r_0906 H+[c] + N-[(R)-4-phosphonopantothenoyl]-L-cysteine[c] => carbon dioxide[c] + pantetheine 4'-phosphate[c] (YKL088W and YKR072C and YOR054C) or (YKL088W and YKR072C) or (YKL088W and YOR054C) or YKL088W 0.00 1000.00 0.00 +r_0906 H+[c] + N-[(R)-4-phosphonopantothenoyl]-L-cysteine[c] => carbon dioxide[c] + pantetheine 4'-phosphate[c] YKL088W and YKR072C and YOR054C 0.00 1000.00 0.00 r_0907 alpha-D-ribose 1-phosphate(2-)[c] <=> ribose-5-phosphate[c] YKL127W or YMR105C or YMR278W -1000.00 1000.00 0.00 r_0908 ATP[c] + L-aspartate[c] + phosphoribosyl-carboxy-aminoimidazole[c] => 5'-phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole[c] + ADP[c] + 2 H+[c] + phosphate[c] YAR015W 0.00 1000.00 0.00 r_0909 1-(5-phosphoribosyl)-5'-AMP[c] + H2O[c] => 1-(5-phospho-D-ribosyl)-5-[(5-phospho-D-ribosylamino)methylideneamino]imidazole-4-carboxamide[c] YCL030C 0.00 1000.00 0.00 @@ -719,7 +719,7 @@ r_0939 NADP(+)[c] + prephenate[c] => 3-(4-hydroxyphenyl)pyruvate[c] + carbon dio r_0940 FAD[m] + L-proline[m] => 1-pyrroline-5-carboxylate[m] + FADH2[m] YLR142W 0.00 1000.00 0.00 r_0941 ATP[c] + L-proline[c] + tRNA(Pro)[c] => AMP[c] + diphosphate[c] + Pro-tRNA(Pro)[c] YHR020W 0.00 1000.00 0.00 r_0942 3 oxygen[m] + 2 protoporphyrinogen[m] => 6 H2O[m] + 2 protoporphyrin[m] YER014W 0.00 1000.00 0.00 -r_0943 nicotinamide riboside[c] + phosphate[c] => alpha-D-ribose 1-phosphate(2-)[c] + H+[c] + nicotinamide[c] YDR400W and YLR017W and YLR209C 0.00 1000.00 0.00 +r_0943 nicotinamide riboside[c] + phosphate[c] => alpha-D-ribose 1-phosphate(2-)[c] + H+[c] + nicotinamide[c] YLR209C 0.00 1000.00 0.00 r_0949 guanosine[c] + phosphate[c] <=> alpha-D-ribose 1-phosphate(2-)[c] + guanine[c] YLR209C -1000.00 1000.00 0.00 r_0950 guanosine[m] + phosphate[m] <=> alpha-D-ribose 1-phosphate(2-)[m] + guanine[m] YLR209C -1000.00 1000.00 0.00 r_0951 inosine[c] + phosphate[c] <=> alpha-D-ribose 1-phosphate(2-)[c] + hypoxanthine[c] YLR209C -1000.00 1000.00 0.00 @@ -733,7 +733,7 @@ r_0959 H+[c] + pyruvate[c] => acetaldehyde[c] + carbon dioxide[c] YGR087C or YL r_0960 acetaldehyde[c] + H+[c] + pyruvate[c] => (R)-acetoin[c] + carbon dioxide[c] YGR087C or YLR044C or YLR134W 0.00 1000.00 0.00 r_0961 coenzyme A[m] + NAD[m] + pyruvate[m] => acetyl-CoA[m] + carbon dioxide[m] + NADH[m] YBR221C and YER178W and YFL018C and YGR193C and YNL071W 0.00 1000.00 0.00 r_0962 ADP[c] + H+[c] + phosphoenolpyruvate[c] => ATP[c] + pyruvate[c] YAL038W or YOR347C 0.00 1000.00 0.00 -r_0963 2-hexaprenyl-6-methoxy-3-methyl-1,4-benzoquinone[m] + H+[m] + NADH[m] + oxygen[m] => 2-hexaprenyl-5-hydroxy-6-methoxy-3-methyl-1,4-benzoquinone[m] + H2O[m] + NAD[m] YDR204W and YGL119W and YGR255C and YLR201C and YML110C and YOL096C and YOR125C 0.00 1000.00 0.00 +r_0963 2-hexaprenyl-6-methoxy-3-methyl-1,4-benzoquinone[m] + H+[m] + NADH[m] + oxygen[m] => 2-hexaprenyl-5-hydroxy-6-methoxy-3-methyl-1,4-benzoquinone[m] + H2O[m] + NAD[m] YDR204W and YGR255C and YLR201C and YML110C and YOL096C and YOR125C 0.00 1000.00 0.00 r_0964 ATP[c] + glutathione[c] + H2O[c] => ADP[c] + glutathione[v] + H+[c] + phosphate[c] YDR135C 0.00 1000.00 0.00 r_0965 ATP[c] + riboflavin[c] => ADP[c] + FMN[c] + H+[c] YDR236C 0.00 1000.00 0.00 r_0966 ATP[m] + riboflavin[m] => ADP[m] + FMN[m] + H+[m] YDR236C 0.00 1000.00 0.00 @@ -753,14 +753,14 @@ r_0979 GDP[n] + H+[n] + TRX1[n] => dGDP[n] + H2O[n] + TRX1 disulphide[n] YER070 r_0982 D-ribulose 5-phosphate[c] <=> ribose-5-phosphate[c] YOR095C -1000.00 1000.00 0.00 r_0983 ATP[c] + nicotinamide riboside[c] => ADP[c] + H+[c] + NMN[c] YNL129W 0.00 1000.00 0.00 r_0984 D-ribulose 5-phosphate[c] <=> D-xylulose 5-phosphate[c] YJL121C -1000.00 1000.00 0.00 -r_0985 3-hexaprenyl-4,5-dihydroxybenzoic acid[m] + S-adenosyl-L-methionine[m] => 3-hexaprenyl-4-hydroxy-5-methoxybenzoic acid[m] + H+[m] + S-adenosyl-L-homocysteine[m] YDR204W and YGL119W and YGR255C and YLR201C and YML110C and YOL096C and YOR125C 0.00 1000.00 0.00 +r_0985 3-hexaprenyl-4,5-dihydroxybenzoic acid[m] + S-adenosyl-L-methionine[m] => 3-hexaprenyl-4-hydroxy-5-methoxybenzoic acid[m] + H+[m] + S-adenosyl-L-homocysteine[m] YDR204W and YGR255C and YLR201C and YML110C and YOL096C and YOR125C 0.00 1000.00 0.00 r_0986 S-adenosyl-L-methionine[c] + zymosterol[c] => fecosterol[c] + H+[c] + S-adenosyl-L-homocysteine[c] YML008C 0.00 1000.00 0.00 r_0987 H2O[c] + S-formylglutathione[c] => formate[c] + glutathione[c] + H+[c] YJL068C 0.00 1000.00 0.00 r_0988 H2O[c] + L-saccharopine[c] + NAD[c] => 2-oxoglutarate[c] + H+[c] + L-lysine[c] + NADH[c] YIR034C 0.00 1000.00 0.00 r_0989 H+[c] + L-allysine[c] + L-glutamate[c] + NADPH[c] => H2O[c] + L-saccharopine[c] + NADP(+)[c] YNR050C 0.00 1000.00 0.00 r_0990 sedoheptulose 1,7-bisphosphate[c] <=> D-erythrose 4-phosphate[c] + dihydroxyacetone phosphate[c] YKL060C -1000.00 1000.00 0.00 -r_0992 acetyl-CoA[c] + L-serine[c] => coenzyme A[c] + O-acetyl-L-serine[c] (YDL040C and YGR147C and YHR013C) or (YDL040C and YGR147C) 0.00 1000.00 0.00 -r_0993 H+[er] + L-serine[er] + palmitoyl-CoA[er] => 3-ketosphinganine[er] + carbon dioxide[er] + coenzyme A[er] (YBR058C-A and YDR062W and YMR296C) or (YDR062W and YMR296C) 0.00 1000.00 0.00 +r_0992 acetyl-CoA[c] + L-serine[c] => coenzyme A[c] + O-acetyl-L-serine[c] YHR013C and YDL040C and YOR253W 0.00 1000.00 0.00 +r_0993 H+[er] + L-serine[er] + palmitoyl-CoA[er] => 3-ketosphinganine[er] + carbon dioxide[er] + coenzyme A[er] YMR296C and YKL212W and YDR062W and YGR038W and YLR350W and YBR058C-A 0.00 1000.00 0.00 r_0995 ATP[c] + L-serine[c] + tRNA(Ser)[c] => AMP[c] + diphosphate[c] + Ser-tRNA(Ser)[c] YDR023W or YHR011W 0.00 1000.00 0.00 r_0996 3-dehydroshikimate[c] + H+[c] + NADPH[c] => NADP(+)[c] + shikimate[c] YDR127W 0.00 1000.00 0.00 r_0997 ATP[c] + shikimate[c] => 3-phosphoshikimic acid[c] + ADP[c] + H+[c] YDR127W 0.00 1000.00 0.00 @@ -835,8 +835,8 @@ r_1081 4 H+[c] + uroporphyrinogen III[c] => 4 carbon dioxide[c] + coproporphyrin r_1082 2 S-adenosyl-L-methionine[c] + uroporphyrinogen III[c] => H+[c] + precorrin-2[c] + 2 S-adenosyl-L-homocysteine[c] YKR069W 0.00 1000.00 0.00 r_1083 preuroporphyrinogen[c] => H2O[c] + uroporphyrinogen III[c] YOR278W 0.00 1000.00 0.00 r_1084 D-glucose 1-phosphate[c] + H+[c] + UTP[c] <=> diphosphate[c] + UDP-D-glucose[c] YHL012W or YKL035W -1000.00 1000.00 0.00 -r_1085 ATP[c] + H+[c] + H2O[c] => ADP[c] + 2 H+[g] + phosphate[c] YBR127C and YDL185W and YEL027W and YEL051W and YGR020C and YHR026W and YHR039C-A and YKL080W and YLR447C and YMR054W and YOR332W and YPL234C and YPR036W 0.00 1000.00 0.00 -r_1086 ATP[c] + H+[c] + H2O[c] => ADP[c] + 2 H+[v] + phosphate[c] YBR127C and YDL185W and YEL027W and YEL051W and YGR020C and YHR026W and YHR039C-A and YKL080W and YLR447C and YOR270C and YOR332W and YPL234C and YPR036W 0.00 1000.00 0.00 +r_1085 ATP[c] + H+[c] + H2O[c] => ADP[c] + 2 H+[g] + phosphate[c] (YPR170W-B and YBR127C and YDL185W and YOR332W and YHR026W and YEL027W and YKL080W and YLR447C and YEL051W and YPL234C and YMR054W and YGR020C and YPR036W and YHR039C-A and YGR106C and YCL005W-A) or (YBR127C and YDL185W and YOR332W and YHR026W and YEL027W and YKL080W and YLR447C and YEL051W and YPL234C and YMR054W and YGR020C and YPR036W and YHR039C-A and YGR106C and YCL005W-A) 0.00 1000.00 0.00 +r_1086 ATP[c] + H+[c] + H2O[c] => ADP[c] + 2 H+[v] + phosphate[c] (YBR127C and YDL185W and YEL027W and YEL051W and YGR020C and YHR026W and YHR039C-A and YKL080W and YLR447C and YOR270C and YOR332W and YPL234C and YPR036W and YPR170W-B and YGR106C and YCL005W-A) or (YBR127C and YDL185W and YEL027W and YEL051W and YGR020C and YHR026W and YHR039C-A and YKL080W and YLR447C and YOR270C and YOR332W and YPL234C and YPR036W and YGR106C and YCL005W-A) 0.00 1000.00 0.00 r_1087 2-oxoglutarate[c] + L-valine[c] <=> 3-methyl-2-oxobutanoate[c] + L-glutamate[c] YJR148W -1000.00 1000.00 0.00 r_1088 2-oxoglutarate[m] + L-valine[m] <=> 3-methyl-2-oxobutanoate[m] + L-glutamate[m] YHR208W -1000.00 1000.00 0.00 r_1089 ATP[c] + L-valine[c] + tRNA(Val)[c] => AMP[c] + diphosphate[c] + Val-tRNA(Val)[c] YGR094W 0.00 1000.00 0.00 @@ -846,7 +846,7 @@ r_1092 NAD[c] + xylitol[c] => D-xylulose[c] + H+[c] + NADH[c] YLR070C 0.00 10 r_1093 D-xylose[c] + H+[c] + NADPH[c] => NADP(+)[c] + xylitol[c] YHR104W 0.00 1000.00 0.00 r_1094 ATP[c] + D-xylulose[c] => ADP[c] + D-xylulose 5-phosphate[c] + H+[c] YGR194C 0.00 1000.00 0.00 r_1095 ribose-5-phosphate[c] + uracil[c] <=> H2O[c] + pseudouridine 5'-phosphate[c] YFL001W or YGL063W or YNL292W or YPL212C -1000.00 1000.00 0.00 -r_1096 (R)-mevalonate[e] <=> (R)-mevalonate[c] -1000.00 1000.00 0.00 +r_1096 (R)-mevalonate[e] <=> (R)-mevalonate[c] YNL065W or YKL217W -1000.00 1000.00 0.00 r_1097 (R,R)-2,3-butanediol[c] <=> (R,R)-2,3-butanediol[e] -1000.00 1000.00 0.00 r_1098 2-methylbutyl acetate[c] => 2-methylbutyl acetate[e] 0.00 1000.00 0.00 r_1099 2-oxoadipic acid[m] + 2-oxoglutarate[c] <=> 2-oxoadipic acid[c] + 2-oxoglutarate[m] YOR222W or YPL134C -1000.00 1000.00 0.00 @@ -857,7 +857,7 @@ r_1103 5-formyltetrahydrofolic acid[e] <=> 5-formyltetrahydrofolic acid[c] -10 r_1104 8-amino-7-oxononanoate[e] + H+[e] <=> 8-amino-7-oxononanoate[c] + H+[c] YNR056C -1000.00 1000.00 0.00 r_1106 acetate[c] <=> acetate[e] YCR010C -1000.00 1000.00 0.00 r_1107 ethyl acetate[c] => ethyl acetate[e] 0.00 1000.00 0.00 -r_1108 adenine[e] + H+[e] => adenine[c] + H+[c] YER056C or YER060W or YER060W-A or YGL186C 0.00 1000.00 0.00 +r_1108 adenine[e] + H+[e] => adenine[c] + H+[c] YER056C or YER060W or YER060W-A 0.00 1000.00 0.00 r_1109 adenosine[e] + H+[e] => adenosine[c] + H+[c] YAL022C 0.00 1000.00 0.00 r_1110 ADP[c] + ATP[m] <=> ADP[m] + ATP[c] YBL030C or YBR085W or YMR056C -1000.00 1000.00 0.00 r_1111 ADP[p] + ATP[c] + H+[p] => ADP[c] + ATP[p] + H+[c] YPR128C 0.00 1000.00 0.00 @@ -883,11 +883,11 @@ r_1131 CMP[m] + CTP[c] + 2 H+[c] => CMP[c] + CTP[m] + 2 H+[m] YBR192W 0.00 10 r_1132 cytidine[e] + H+[e] => cytidine[c] + H+[c] YAL022C 0.00 1000.00 0.00 r_1133 cytosine[e] + H+[e] => cytosine[c] + H+[c] YER056C or YER060W or YER060W-A or YGL186C 0.00 1000.00 0.00 r_1134 D-fructose[e] + H+[e] => D-fructose[c] + H+[c] YDL245C or YDR342C or YDR343C or YDR345C or YEL069C or YFL011W or YHR092C or YHR094C or YHR096C or YJL214W or YJL219W or YJR158W or YMR011W or YNR072W or YOL156W 0.00 1000.00 0.00 -r_1135 D-galactose[e] + H+[e] => D-galactose[c] + H+[c] YDR536W or YFL011W or YJL219W or YLR081W or YNL318C or YOL156W 0.00 1000.00 0.00 +r_1135 D-galactose[e] + H+[e] => D-galactose[c] + H+[c] YFL011W or YJL219W or YLR081W or YNL318C or YOL156W 0.00 1000.00 0.00 r_1136 (R)-lactate[e] + H+[e] <=> (R)-lactate[c] + H+[c] YKL217W -1000.00 1000.00 0.00 r_1137 (R)-lactate[c] + H+[c] => (R)-lactate[m] + H+[m] 0.00 1000.00 0.00 r_1138 (R)-lactate[c] + pyruvate[m] <=> (R)-lactate[m] + pyruvate[c] -1000.00 1000.00 0.00 -r_1139 D-mannose[e] + H+[e] => D-mannose[c] + H+[c] YDL245C or YDR342C or YDR343C or YDR345C or YEL069C or YFL011W or YHR092C or YHR094C or YHR096C or YJL214W or YJL219W or YJR158W or YMR011W or YNR072W or YOL156W 0.00 1000.00 0.00 +r_1139 D-mannose[e] + H+[e] => D-mannose[c] + H+[c] YDL245C or YDR342C or YHR094C or YDR343C or YDR345C or YEL069C or YFL011W or YHR096C or YJL214W or YJL219W or YJR158W or YNR072W or YOL156W 0.00 1000.00 0.00 r_1146 episterol[e] <=> episterol[c] YIL013C or YOR011W -1000.00 1000.00 0.00 r_1147 ergosterol[e] <=> ergosterol[c] YIL013C or YOR011W -1000.00 1000.00 0.00 r_1148 ergosterol[ce] <=> ergosterol[c] YIL013C or YOR011W -1000.00 1000.00 0.00 @@ -907,14 +907,14 @@ r_1172 glycerol[c] => glycerol[e] YFL054C or YLL043W 0.00 1000.00 0.00 r_1173 H+[e] + L-glycine[e] <=> H+[c] + L-glycine[c] YCL025C or YKR039W or YOL020W or YOR348C or YPL265W -1000.00 1000.00 0.00 r_1174 glycogen[c] => glycogen[v] 0.00 1000.00 0.00 r_1175 GDP[m] + GTP[c] + H+[c] => GDP[c] + GTP[m] + H+[m] YDL198C 0.00 1000.00 0.00 -r_1176 guanine[e] + H+[e] <=> guanine[c] + H+[c] YER056C or YER060W or YER060W-A or YGL186C -1000.00 1000.00 0.00 +r_1176 guanine[e] + H+[e] <=> guanine[c] + H+[c] YER056C or YER060W or YER060W-A -1000.00 1000.00 0.00 r_1177 H+[e] + myo-inositol[e] => H+[c] + myo-inositol[c] YDR497C or YOL103W 0.00 1000.00 0.00 r_1178 iron(2+)[e] => iron(2+)[c] YMR319C or YMR058W 0.00 1000.00 0.00 r_1179 iron(2+)[c] => iron(2+)[m] YJL133W or YKR052C 0.00 1000.00 0.00 r_1180 isoamyl acetate[c] => isoamyl acetate[e] 0.00 1000.00 0.00 r_1181 isobutyl acetate[c] => isobutyl acetate[e] 0.00 1000.00 0.00 r_1182 isopentenyl diphosphate[c] <=> isopentenyl diphosphate[m] -1000.00 1000.00 0.00 -r_1183 H+[e] + L-alanine[e] <=> H+[c] + L-alanine[c] YBR068C or YCL025C or YDR046C or YKR039W or YOL020W or YOR348C or YPL265W -1000.00 1000.00 0.00 +r_1183 H+[e] + L-alanine[e] <=> H+[c] + L-alanine[c] YCL025C or YKR039W or YOR348C or YPL265W -1000.00 1000.00 0.00 r_1184 H+[e] + L-arginine[e] <=> H+[c] + L-arginine[c] YEL063C or YKR039W or YNL270C -1000.00 1000.00 0.00 r_1185 H+[v] + L-arginine[c] => H+[c] + L-arginine[v] YOL092W or YBR293W 0.00 1000.00 0.00 r_1186 H+[e] + L-asparagine[e] <=> H+[c] + L-asparagine[c] YCL025C or YDR508C or YKR039W or YPL265W -1000.00 1000.00 0.00 @@ -949,7 +949,7 @@ r_1214 H+[e] + L-methionine[e] <=> H+[c] + L-methionine[c] YBR068C or YCL025C o r_1215 H+[e] + L-phenylalanine[e] <=> H+[c] + L-phenylalanine[c] YBR068C or YCL025C or YDR046C or YKR039W or YOL020W -1000.00 1000.00 0.00 r_1216 H+[e] + L-proline[e] <=> H+[c] + L-proline[c] YKR039W or YOR348C -1000.00 1000.00 0.00 r_1217 H+[e] + L-serine[e] <=> H+[c] + L-serine[c] YCL025C or YDR508C or YFL055W or YKR039W or YPL265W or YDR105C -1000.00 1000.00 0.00 -r_1218 H+[e] + L-threonine[e] <=> H+[c] + L-threonine[c] YBR069C or YCL025C or YDR046C or YDR508C or YKR039W -1000.00 1000.00 0.00 +r_1218 H+[e] + L-threonine[e] <=> H+[c] + L-threonine[c] YCL025C or YDR508C or YKR039W -1000.00 1000.00 0.00 r_1219 H+[e] + L-tryptophan[e] <=> H+[c] + L-tryptophan[c] YBR068C or YBR069C or YDR046C or YKR039W or YOL020W -1000.00 1000.00 0.00 r_1220 L-tyrosine[v] <=> L-tyrosine[c] YCL038C -1000.00 1000.00 0.00 r_1221 H+[v] + L-tyrosine[c] => H+[c] + L-tyrosine[v] YBR293W or YJR001W 0.00 1000.00 0.00 @@ -967,7 +967,7 @@ r_1232 dGMP[m] + NAD[c] => dGMP[c] + NAD[m] YIL006W 0.00 1000.00 0.00 r_1235 nicotinate[e] <=> nicotinate[c] YGR260W -1000.00 1000.00 0.00 r_1236 stearate[c] <=> stearate[p] YKL188C and YPL147W -1000.00 1000.00 0.00 r_1237 H+[c] + ornithine[m] => H+[m] + ornithine[c] YOR130C 0.00 1000.00 0.00 -r_1238 H+[e] + ornithine[e] <=> H+[c] + ornithine[c] YEL063C or YKR039W -1000.00 1000.00 0.00 +r_1238 H+[e] + ornithine[e] <=> H+[c] + ornithine[c] YKR039W -1000.00 1000.00 0.00 r_1239 H+[c] + oxaloacetate[c] => H+[m] + oxaloacetate[m] YKL120W 0.00 1000.00 0.00 r_1241 (R)-pantothenate[e] + H+[e] <=> (R)-pantothenate[c] + H+[c] YCR028C -1000.00 1000.00 0.00 r_1242 pentaprenyl diphosphate[c] <=> pentaprenyl diphosphate[m] -1000.00 1000.00 0.00 @@ -1066,7 +1066,7 @@ r_1580 2-methylbutanol[e] => 0.00 1000.00 0.00 r_1581 2-methylbutyl acetate[e] => 0.00 1000.00 0.00 r_1582 isobutyraldehyde[c] <=> isobutyraldehyde[e] -1000.00 1000.00 0.00 r_1583 isobutyraldehyde[c] <=> isobutyraldehyde[m] -1000.00 1000.00 0.00 -r_1585 2-oxobutanoate[c] <=> 2-oxobutanoate[m] -1000.00 1000.00 0.00 +r_1585 2-oxobutanoate[c] <=> 2-oxobutanoate[m] YNL065W or YKL217W -1000.00 1000.00 0.00 r_1586 2-oxoglutarate[e] => 0.00 1000.00 0.00 r_1587 2-oxoglutarate[c] <=> 2-oxoglutarate[n] -1000.00 1000.00 0.00 r_1588 2-oxoglutarate[e] <=> 2-oxoglutarate[c] -1000.00 1000.00 0.00 @@ -1090,10 +1090,10 @@ r_1609 4-hydroxy-2-oxoglutarate[c] <=> 4-hydroxy-2-oxoglutarate[m] -1000.00 10 r_1610 4-hydroxy-2-oxoglutarate[c] <=> 4-hydroxy-2-oxoglutarate[p] -1000.00 1000.00 0.00 r_1611 4-hydroxybenzoate[c] <=> 4-hydroxybenzoate[m] -1000.00 1000.00 0.00 r_1613 AMP[c] + H2O[c] => adenosine[c] + phosphate[c] 0.00 1000.00 0.00 -r_1614 dAMP[c] + H2O[c] => 2'-deoxyadenosine[c] + phosphate[c] 0.00 1000.00 0.00 -r_1615 dCMP[c] + H2O[c] => deoxycytidine[c] + phosphate[c] 0.00 1000.00 0.00 -r_1616 dGMP[c] + H2O[c] => 2'-deoxyguanosine[c] + phosphate[c] 0.00 1000.00 0.00 -r_1617 dTMP[c] + H2O[c] => phosphate[c] + thymidine[c] 0.00 1000.00 0.00 +r_1614 dAMP[c] + H2O[c] => 2'-deoxyadenosine[c] + phosphate[c] YGL101W or YBR242W 0.00 1000.00 0.00 +r_1615 dCMP[c] + H2O[c] => deoxycytidine[c] + phosphate[c] YGL101W or YBR242W 0.00 1000.00 0.00 +r_1616 dGMP[c] + H2O[c] => 2'-deoxyguanosine[c] + phosphate[c] YGL101W or YBR242W 0.00 1000.00 0.00 +r_1617 dTMP[c] + H2O[c] => phosphate[c] + thymidine[c] YGL101W or YBR242W 0.00 1000.00 0.00 r_1618 dUMP[c] + H2O[c] => 2'-deoxyuridine[c] + phosphate[c] 0.00 1000.00 0.00 r_1619 GMP[c] + H2O[c] => guanosine[c] + phosphate[c] YER037W 0.00 1000.00 0.00 r_1620 H2O[c] + xanthosine-5-phosphate[c] => phosphate[c] + xanthosine[c] 0.00 1000.00 0.00 @@ -1168,8 +1168,8 @@ r_1698 coenzyme A[c] <=> coenzyme A[er] -1000.00 1000.00 0.00 r_1699 coenzyme A[c] <=> coenzyme A[n] -1000.00 1000.00 0.00 r_1700 coenzyme A[p] <=> coenzyme A[c] -1000.00 1000.00 0.00 r_1702 cytidine[e] => 0.00 1000.00 0.00 -r_1703 ATP[c] + CMP[c] => ADP[c] + CDP[c] 0.00 1000.00 0.00 -r_1704 ATP[c] + dCMP[c] <=> ADP[c] + dCDP[c] -1000.00 1000.00 0.00 +r_1703 ATP[c] + CMP[c] => ADP[c] + CDP[c] YKL024C 0.00 1000.00 0.00 +r_1704 ATP[c] + dCMP[c] <=> ADP[c] + dCDP[c] YKL024C -1000.00 1000.00 0.00 r_1705 cytosine[e] => 0.00 1000.00 0.00 r_1706 D-arabinose[e] => 0.00 1000.00 0.00 r_1707 D-arabinose[e] <=> D-arabinose[c] YDR342C or YHR092C -1000.00 1000.00 0.00 @@ -1201,7 +1201,7 @@ r_1732 2'-deoxyguanosine[e] => 2'-deoxyguanosine[c] 0.00 1000.00 0.00 r_1733 2'-deoxyinosine[e] => 2'-deoxyinosine[c] 0.00 1000.00 0.00 r_1734 2'-deoxyuridine[c] + ATP[c] => ADP[c] + dUMP[c] + H+[c] 0.00 1000.00 0.00 r_1735 2'-deoxyuridine[e] => 2'-deoxyuridine[c] YBL042C 0.00 1000.00 0.00 -r_1736 3'-dephospho-CoA[c] + ATP[c] => ADP[c] + coenzyme A[c] + H+[c] 0.00 1000.00 0.00 +r_1736 3'-dephospho-CoA[c] + ATP[c] => ADP[c] + coenzyme A[c] + H+[c] YDR196C 0.00 1000.00 0.00 r_1737 dGDP[c] <=> dGDP[n] -1000.00 1000.00 0.00 r_1738 7,8-dihydroneopterin[c] <=> 7,8-dihydroneopterin[m] -1000.00 1000.00 0.00 r_1739 acetyl-CoA[c] + spermine[c] => coenzyme A[c] + H+[c] + N(1)-acetylspermine[c] YDR071C 0.00 1000.00 0.00 @@ -1226,11 +1226,11 @@ r_1763 ethanol[c] <=> ethanol[m] -1000.00 1000.00 0.00 r_1764 ethanolamine[e] => 0.00 1000.00 0.00 r_1765 ethyl acetate[e] => 0.00 1000.00 0.00 r_1766 farnesyl diphosphate[c] <=> farnesyl diphosphate[m] -1000.00 1000.00 0.00 -r_1770 decanoate[c] <=> decanoate[p] -1000.00 1000.00 0.00 +r_1770 decanoate[c] <=> decanoate[p] YBR041W -1000.00 1000.00 0.00 r_1771 laurate[c] <=> laurate[p] YKL188C and YPL147W -1000.00 1000.00 0.00 r_1772 myristate[c] <=> myristate[p] YKL188C and YPL147W -1000.00 1000.00 0.00 r_1774 palmitate[c] <=> palmitate[p] YKL188C and YPL147W -1000.00 1000.00 0.00 -r_1775 palmitoleate[c] <=> palmitoleate[p] -1000.00 1000.00 0.00 +r_1775 palmitoleate[c] <=> palmitoleate[p] YBR041W -1000.00 1000.00 0.00 r_1776 octanoate[c] <=> octanoate[p] -1000.00 1000.00 0.00 r_1777 myristate[e] <=> myristate[c] -1000.00 1000.00 0.00 r_1788 fecosterol[e] => 0.00 1000.00 0.00 @@ -1247,7 +1247,7 @@ r_1800 gamma-aminobutyrate[e] => 0.00 1000.00 0.00 r_1801 GDP[g] <=> GDP[c] -1000.00 1000.00 0.00 r_1802 GDP[c] <=> GDP[n] -1000.00 1000.00 0.00 r_1803 GDP-alpha-D-mannose[c] <=> GDP-alpha-D-mannose[g] YGL225W -1000.00 1000.00 0.00 -r_1805 D-glucose[c] <=> D-glucose[v] YBR241C or YGL104C -1000.00 1000.00 0.00 +r_1805 D-glucose[c] <=> D-glucose[v] YBR241C -1000.00 1000.00 0.00 r_1806 glutathione disulfide[e] => 0.00 1000.00 0.00 r_1807 glutathione[e] => 0.00 1000.00 0.00 r_1808 glycerol[e] => 0.00 1000.00 0.00 @@ -1276,8 +1276,8 @@ r_1831 H+[c] <=> H+[v] -1000.00 1000.00 0.00 r_1832 H+[e] <=> -1000.00 1000.00 0.00 r_1833 hexacosanoyl-CoA[c] <=> hexacosanoyl-CoA[er] -1000.00 1000.00 0.00 r_1834 hexadecanal[e] => 0.00 1000.00 0.00 -r_1835 palmitate[e] <=> palmitate[c] -1000.00 1000.00 0.00 -r_1836 palmitoleate[e] <=> palmitoleate[c] -1000.00 1000.00 0.00 +r_1835 palmitate[e] <=> palmitate[c] YBR041W -1000.00 1000.00 0.00 +r_1836 palmitoleate[e] <=> palmitoleate[c] YBR041W -1000.00 1000.00 0.00 r_1837 L-histidine[c] => L-histidine[m] YBR147W 0.00 1000.00 0.00 r_1838 2-oxoglutarate[m] + acetyl-CoA[m] + H2O[m] => coenzyme A[m] + H+[m] + homocitrate[m] YDL131W or YDL182W 0.00 1000.00 0.00 r_1839 hydrogen peroxide[c] <=> hydrogen peroxide[n] -1000.00 1000.00 0.00 @@ -1349,7 +1349,7 @@ r_1906 L-serine[e] => 0.00 1000.00 0.00 r_1907 L-serine[c] <=> L-serine[er] YKR039W -1000.00 1000.00 0.00 r_1908 L-glucitol[e] <=> L-glucitol[c] YDL245C or YEL069C or YJR158W or YNR072W -1000.00 1000.00 0.00 r_1909 L-sorbose[e] => 0.00 1000.00 0.00 -r_1910 L-sorbose[e] <=> L-sorbose[c] YDL245C or YDR342C or YDR343C or YDR345C or YEL069C or YFL011W or YHR092C or YHR094C or YHR096C or YJL214W or YJL219W or YJR158W or YMR011W or YNR072W or YOL156W -1000.00 1000.00 0.00 +r_1910 L-sorbose[e] <=> L-sorbose[c] YDL245C or YDR342C or YDR343C or YDR345C or YEL069C or YFL011W or YHR092C or YHR096C or YJL214W or YJL219W or YJR158W or YNR072W or YOL156W -1000.00 1000.00 0.00 r_1911 L-threonine[e] => 0.00 1000.00 0.00 r_1912 L-tryptophan[e] => 0.00 1000.00 0.00 r_1913 L-tyrosine[e] => 0.00 1000.00 0.00 @@ -1400,7 +1400,7 @@ r_1977 oxygen[c] <=> oxygen[er] -1000.00 1000.00 0.00 r_1978 oxygen[c] <=> oxygen[m] -1000.00 1000.00 0.00 r_1979 oxygen[e] <=> oxygen[c] -1000.00 1000.00 0.00 r_1980 oxygen[c] <=> oxygen[p] -1000.00 1000.00 0.00 -r_1981 stearate[e] <=> stearate[c] -1000.00 1000.00 0.00 +r_1981 stearate[e] <=> stearate[c] YBR041W -1000.00 1000.00 0.00 r_1984 octanoate[e] => 0.00 1000.00 0.00 r_1987 ornithine[e] => 0.00 1000.00 0.00 r_1988 oxaloacetate[c] <=> oxaloacetate[e] -1000.00 1000.00 0.00 @@ -1427,7 +1427,7 @@ r_2022 protoporphyrinogen[c] <=> protoporphyrinogen[m] -1000.00 1000.00 0.00 r_2023 PRPP[c] <=> PRPP[m] -1000.00 1000.00 0.00 r_2024 putrescine[e] => 0.00 1000.00 0.00 r_2025 ATP[c] + pyridoxal[c] => ADP[c] + H+[c] + pyridoxal 5'-phosphate[c] YNR027W 0.00 1000.00 0.00 -r_2026 ATP[c] + pyridoxamine[c] => ADP[c] + H+[c] + pyridoxamine 5'-phosphate[c] 0.00 1000.00 0.00 +r_2026 ATP[c] + pyridoxamine[c] => ADP[c] + H+[c] + pyridoxamine 5'-phosphate[c] YNR027W 0.00 1000.00 0.00 r_2027 H2O[c] + pyridoxamine 5'-phosphate[c] => phosphate[c] + pyridoxamine[c] 0.00 1000.00 0.00 r_2028 pyridoxine[e] => 0.00 1000.00 0.00 r_2029 ATP[c] + pyridoxine[c] => ADP[c] + H+[c] + pyridoxine 5'-phosphate[c] YEL029C 0.00 1000.00 0.00 @@ -1565,13 +1565,13 @@ r_2182 H+[erm] + palmitoyl-CoA[erm] + oxygen[erm] + NADH[erm] => 2 H2O[erm] + pa r_2183 H+[erm] + stearoyl-CoA[erm] + oxygen[erm] + NADH[erm] => 2 H2O[erm] + NAD[erm] + oleoyl-CoA[erm] YGL055W 0.00 1000.00 0.00 r_2184 octanoate[e] <=> octanoate[c] -1000.00 1000.00 0.00 r_2185 decanoate[e] <=> decanoate[c] -1000.00 1000.00 0.00 -r_2186 laurate[e] <=> laurate[c] -1000.00 1000.00 0.00 +r_2186 laurate[e] <=> laurate[c] YBR041W -1000.00 1000.00 0.00 r_2187 butyrate[e] => 0.00 1000.00 0.00 r_2188 hexanoate[e] => 0.00 1000.00 0.00 r_2189 oleate[e] => 0.00 1000.00 0.00 r_2190 butyrate[e] <=> butyrate[c] YNL065W -1000.00 1000.00 0.00 r_2191 hexanoate[e] <=> hexanoate[c] YNL065W -1000.00 1000.00 0.00 -r_2192 oleate[e] <=> oleate[c] -1000.00 1000.00 0.00 +r_2192 oleate[e] <=> oleate[c] YBR041W -1000.00 1000.00 0.00 r_2193 myristate[e] => 0.00 1000.00 0.00 r_2194 coenzyme A[erm] + ATP[erm] + laurate[erm] <=> lauroyl-CoA[erm] + AMP[erm] + diphosphate[erm] YOR317W -1000.00 1000.00 0.00 r_2195 coenzyme A[erm] + ATP[erm] + myristate[erm] <=> myristoyl-CoA[erm] + AMP[erm] + diphosphate[erm] YMR246W or YOR317W -1000.00 1000.00 0.00 @@ -2229,14 +2229,14 @@ r_2848 ATP[n] + H+[n] + 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-18:1)[n] => AD r_2849 ATP[n] + H+[n] + 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-18:1)[n] => ADP[n] + 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-16:1, 2-18:1)[n] YNL267W 0.00 1000.00 0.00 r_2850 ATP[n] + H+[n] + 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-18:1)[n] => ADP[n] + 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-18:0, 2-18:1)[n] YNL267W 0.00 1000.00 0.00 r_2851 ATP[n] + H+[n] + 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-18:1)[n] => ADP[n] + 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-18:1, 2-18:1)[n] YNL267W 0.00 1000.00 0.00 -r_2852 H+[vm] + 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-16:1)[vm] + ATP[vm] => ADP[vm] + 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-16:0, 2-16:1)[vm] YBR097W and YLR240W 0.00 1000.00 0.00 -r_2853 H+[vm] + ATP[vm] + 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-16:1)[vm] => ADP[vm] + 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-16:1, 2-16:1)[vm] YBR097W and YLR240W 0.00 1000.00 0.00 -r_2854 H+[vm] + ATP[vm] + 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-16:1)[vm] => ADP[vm] + 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-18:0, 2-16:1)[vm] YBR097W and YLR240W 0.00 1000.00 0.00 -r_2855 H+[vm] + ATP[vm] + 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-16:1)[vm] => ADP[vm] + 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-18:1, 2-16:1)[vm] YBR097W and YLR240W 0.00 1000.00 0.00 -r_2856 H+[vm] + ATP[vm] + 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-18:1)[vm] => ADP[vm] + 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-16:0, 2-18:1)[vm] YBR097W and YLR240W 0.00 1000.00 0.00 -r_2857 H+[vm] + ATP[vm] + 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-18:1)[vm] => ADP[vm] + 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-16:1, 2-18:1)[vm] YBR097W and YLR240W 0.00 1000.00 0.00 -r_2858 H+[vm] + ATP[vm] + 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-18:1)[vm] => ADP[vm] + 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-18:0, 2-18:1)[vm] YBR097W and YLR240W 0.00 1000.00 0.00 -r_2859 H+[vm] + ATP[vm] + 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-18:1)[vm] => ADP[vm] + 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-18:1, 2-18:1)[vm] YBR097W and YLR240W 0.00 1000.00 0.00 +r_2852 H+[vm] + 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-16:1)[vm] + ATP[vm] => ADP[vm] + 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-16:0, 2-16:1)[vm] (YBR097W and YLR240W) or (YBR097W and YLR240W and YPL120W and YLR360W) or (YBR097W and YLR240W and YBR128C and YPL120W and YLR211C) 0.00 1000.00 0.00 +r_2853 H+[vm] + ATP[vm] + 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-16:1)[vm] => ADP[vm] + 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-16:1, 2-16:1)[vm] (YBR097W and YLR240W) or (YBR097W and YLR240W and YPL120W and YLR360W) or (YBR097W and YLR240W and YBR128C and YPL120W and YLR211C) 0.00 1000.00 0.00 +r_2854 H+[vm] + ATP[vm] + 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-16:1)[vm] => ADP[vm] + 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-18:0, 2-16:1)[vm] (YBR097W and YLR240W) or (YBR097W and YLR240W and YPL120W and YLR360W) or (YBR097W and YLR240W and YBR128C and YPL120W and YLR211C) 0.00 1000.00 0.00 +r_2855 H+[vm] + ATP[vm] + 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-16:1)[vm] => ADP[vm] + 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-18:1, 2-16:1)[vm] (YBR097W and YLR240W) or (YBR097W and YLR240W and YPL120W and YLR360W) or (YBR097W and YLR240W and YBR128C and YPL120W and YLR211C) 0.00 1000.00 0.00 +r_2856 H+[vm] + ATP[vm] + 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-18:1)[vm] => ADP[vm] + 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-16:0, 2-18:1)[vm] (YBR097W and YLR240W) or (YBR097W and YLR240W and YPL120W and YLR360W) or (YBR097W and YLR240W and YBR128C and YPL120W and YLR211C) 0.00 1000.00 0.00 +r_2857 H+[vm] + ATP[vm] + 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-18:1)[vm] => ADP[vm] + 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-16:1, 2-18:1)[vm] (YBR097W and YLR240W) or (YBR097W and YLR240W and YPL120W and YLR360W) or (YBR097W and YLR240W and YBR128C and YPL120W and YLR211C) 0.00 1000.00 0.00 +r_2858 H+[vm] + ATP[vm] + 1-phosphatidyl-1D-myo-inositol (1-18:0, 2-18:1)[vm] => ADP[vm] + 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-18:0, 2-18:1)[vm] (YBR097W and YLR240W) or (YBR097W and YLR240W and YPL120W and YLR360W) or (YBR097W and YLR240W and YBR128C and YPL120W and YLR211C) 0.00 1000.00 0.00 +r_2859 H+[vm] + ATP[vm] + 1-phosphatidyl-1D-myo-inositol (1-18:1, 2-18:1)[vm] => ADP[vm] + 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-18:1, 2-18:1)[vm] (YBR097W and YLR240W) or (YBR097W and YLR240W and YPL120W and YLR360W) or (YBR097W and YLR240W and YBR128C and YPL120W and YLR211C) 0.00 1000.00 0.00 r_2860 ATP[n] + H+[n] + 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-16:0, 2-16:1)[n] => ADP[n] + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-16:0, 2-16:1)[n] YDR208W 0.00 1000.00 0.00 r_2861 ATP[n] + H+[n] + 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-16:1, 2-16:1)[n] => ADP[n] + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-16:1, 2-16:1)[n] YDR208W 0.00 1000.00 0.00 r_2862 ATP[n] + H+[n] + 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-18:0, 2-16:1)[n] => ADP[n] + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-18:0, 2-16:1)[n] YDR208W 0.00 1000.00 0.00 @@ -2583,14 +2583,14 @@ r_3212 H2O[erm] + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-16:0, 2-18: r_3213 H2O[erm] + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-16:1, 2-18:1)[erm] => 2 H+[erm] + phosphate[erm] + 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-16:1, 2-18:1)[erm] YOL065C 0.00 1000.00 0.00 r_3214 H2O[erm] + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-18:0, 2-18:1)[erm] => 2 H+[erm] + phosphate[erm] + 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-18:0, 2-18:1)[erm] YOL065C 0.00 1000.00 0.00 r_3215 H2O[erm] + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (1-18:1, 2-18:1)[erm] => 2 H+[erm] + phosphate[erm] + 1-phosphatidyl-1D-myo-inositol 4-phosphate (1-18:1, 2-18:1)[erm] YOL065C 0.00 1000.00 0.00 -r_3216 H2O[vm] + 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-16:0, 2-16:1)[vm] => phosphate[vm] + 2 H+[vm] + 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-16:0, 2-16:1)[vm] YLR386W and YNL325C 0.00 1000.00 0.00 -r_3217 H2O[vm] + 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-16:1, 2-16:1)[vm] => phosphate[vm] + 2 H+[vm] + 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-16:1, 2-16:1)[vm] YLR386W and YNL325C 0.00 1000.00 0.00 -r_3218 H2O[vm] + 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-18:0, 2-16:1)[vm] => phosphate[vm] + 2 H+[vm] + 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-18:0, 2-16:1)[vm] YLR386W and YNL325C 0.00 1000.00 0.00 -r_3219 H2O[vm] + 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-18:1, 2-16:1)[vm] => phosphate[vm] + 2 H+[vm] + 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-18:1, 2-16:1)[vm] YLR386W and YNL325C 0.00 1000.00 0.00 -r_3220 H2O[vm] + 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-16:0, 2-18:1)[vm] => phosphate[vm] + 2 H+[vm] + 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-16:0, 2-18:1)[vm] YLR386W and YNL325C 0.00 1000.00 0.00 -r_3221 H2O[vm] + 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-16:1, 2-18:1)[vm] => phosphate[vm] + 2 H+[vm] + 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-16:1, 2-18:1)[vm] YLR386W and YNL325C 0.00 1000.00 0.00 -r_3222 H2O[vm] + 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-18:0, 2-18:1)[vm] => phosphate[vm] + 2 H+[vm] + 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-18:0, 2-18:1)[vm] YLR386W and YNL325C 0.00 1000.00 0.00 -r_3223 H2O[vm] + 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-18:1, 2-18:1)[vm] => phosphate[vm] + 2 H+[vm] + 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-18:1, 2-18:1)[vm] YLR386W and YNL325C 0.00 1000.00 0.00 +r_3216 H2O[vm] + 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-16:0, 2-16:1)[vm] => phosphate[vm] + 2 H+[vm] + 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-16:0, 2-16:1)[vm] YFR019W and YNL325C and YFR021W and YNL054W and YLR386W 0.00 1000.00 0.00 +r_3217 H2O[vm] + 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-16:1, 2-16:1)[vm] => phosphate[vm] + 2 H+[vm] + 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-16:1, 2-16:1)[vm] YFR019W and YNL325C and YFR021W and YNL054W and YLR386W 0.00 1000.00 0.00 +r_3218 H2O[vm] + 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-18:0, 2-16:1)[vm] => phosphate[vm] + 2 H+[vm] + 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-18:0, 2-16:1)[vm] YFR019W and YNL325C and YFR021W and YNL054W and YLR386W 0.00 1000.00 0.00 +r_3219 H2O[vm] + 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-18:1, 2-16:1)[vm] => phosphate[vm] + 2 H+[vm] + 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-18:1, 2-16:1)[vm] YFR019W and YNL325C and YFR021W and YNL054W and YLR386W 0.00 1000.00 0.00 +r_3220 H2O[vm] + 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-16:0, 2-18:1)[vm] => phosphate[vm] + 2 H+[vm] + 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-16:0, 2-18:1)[vm] YFR019W and YNL325C and YFR021W and YNL054W and YLR386W 0.00 1000.00 0.00 +r_3221 H2O[vm] + 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-16:1, 2-18:1)[vm] => phosphate[vm] + 2 H+[vm] + 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-16:1, 2-18:1)[vm] YFR019W and YNL325C and YFR021W and YNL054W and YLR386W 0.00 1000.00 0.00 +r_3222 H2O[vm] + 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-18:0, 2-18:1)[vm] => phosphate[vm] + 2 H+[vm] + 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-18:0, 2-18:1)[vm] YFR019W and YNL325C and YFR021W and YNL054W and YLR386W 0.00 1000.00 0.00 +r_3223 H2O[vm] + 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (1-18:1, 2-18:1)[vm] => phosphate[vm] + 2 H+[vm] + 1-phosphatidyl-1D-myo-inositol 3-phosphate (1-18:1, 2-18:1)[vm] YFR019W and YNL325C and YFR021W and YNL054W and YLR386W 0.00 1000.00 0.00 r_3224 H2O[vm] + 1,2-diacylglycerol 3-diphosphate (1-16:0, 2-16:1)[vm] => phosphatidate (1-16:0, 2-16:1)[vm] + phosphate[vm] + 2 H+[vm] YDR284C 0.00 1000.00 0.00 r_3225 H2O[vm] + 1,2-diacylglycerol 3-diphosphate (1-16:1, 2-16:1)[vm] => phosphate[vm] + phosphatidate (1-16:1, 2-16:1)[vm] + 2 H+[vm] YDR284C 0.00 1000.00 0.00 r_3226 H2O[vm] + 1,2-diacylglycerol 3-diphosphate (1-18:0, 2-16:1)[vm] => phosphate[vm] + phosphatidate (1-18:0, 2-16:1)[vm] + 2 H+[vm] YDR284C 0.00 1000.00 0.00 @@ -3328,7 +3328,7 @@ r_3957 H+[m] <=> H+[mm] -1000.00 1000.00 0.00 r_3958 glycerol 3-phosphate[m] <=> glycerol 3-phosphate[mm] -1000.00 1000.00 0.00 r_3959 CMP[m] <=> CMP[mm] YBR192W -1000.00 1000.00 0.00 r_3960 CTP[m] <=> CTP[mm] YBR192W -1000.00 1000.00 0.00 -r_3961 phosphate[m] <=> phosphate[mm] YER053C or YJR077C or YLR348C -1000.00 1000.00 0.00 +r_3961 phosphate[m] <=> phosphate[mm] YER053C or YJR077C -1000.00 1000.00 0.00 r_3962 diphosphate[m] <=> diphosphate[mm] -1000.00 1000.00 0.00 r_3963 1-phosphatidyl-1D-myo-inositol (1-16:0, 2-16:1)[c] => 0.80903 1-phosphatidyl-1D-myo-inositol backbone[c] + 0.25643 C16:0 chain[c] + 0.25441 C16:1 chain[c] 0.00 1000.00 0.00 r_3964 1-phosphatidyl-1D-myo-inositol (1-16:1, 2-16:1)[c] => 0.80701 1-phosphatidyl-1D-myo-inositol backbone[c] + 0.50883 C16:1 chain[c] 0.00 1000.00 0.00 @@ -3534,8 +3534,8 @@ r_4164 ATP[p] + coenzyme A[p] + Oxalate[p] <=> AMP[p] + diphosphate[p] + Oxalyl- r_4165 H2O[er] + G00171[er] <=> D-glucose[er] + G00010[er] YBR229C -1000.00 1000.00 0.00 r_4166 H2O[er] + G00010[er] <=> D-glucose[er] + G00011[er] YBR229C -1000.00 1000.00 0.00 r_4167 sodium[v] + potassium[v] + chloride[v] <=> potassium[c] + sodium[c] + chloride[c] YBR235W -1000.00 1000.00 0.00 -r_4168 D-fructose[c] <=> D-fructose[v] YBR241C or YGL104C -1000.00 1000.00 0.00 -r_4169 D-galactose[c] <=> D-galactose[v] YBR241C or YGL104C -1000.00 1000.00 0.00 +r_4168 D-fructose[c] <=> D-fructose[v] YBR241C -1000.00 1000.00 0.00 +r_4169 D-galactose[c] <=> D-galactose[v] YBR241C -1000.00 1000.00 0.00 r_4170 dolichyl phosphate[er] + UDP-N-acetyl-alpha-D-glucosamine[er] <=> N-Acetyl-D-glucosaminyldiphosphodolichol[er] + UMP[er] YBR243C -1000.00 1000.00 0.00 r_4171 glutathione[c] + H2O[c] => L-cysteinylglycine[c] + L-glutamate[c] YBR281C and YNL191W 0.00 1000.00 0.00 r_4172 ATP[c] + H2O[c] + cadmium(2+)[c] => ADP[c] + H+[c] + phosphate[c] + cadmium(2+)[e] YBR295W 0.00 1000.00 0.00 @@ -3595,7 +3595,7 @@ r_4227 H2O[c] + 2-Phenylacetamide[c] <=> ammonium[c] + phenylacetic acid[c] YDR r_4228 H2O[c] + (Indol-3-yl)acetamide[c] => ammonium[c] + indole-3-acetate[c] YDR242W 0.00 1000.00 0.00 r_4230 ammonium[c] + Acrylic acid[c] <=> H2O[c] + Acrylamide[c] YDR242W -1000.00 1000.00 0.00 r_4231 H2O[c] + Benzamide[c] <=> ammonium[c] + Benzoate[c] YDR242W -1000.00 1000.00 0.00 -r_4232 ATP[c] + D-gluconate[c] => 6-phospho-D-gluconate[c] + ADP[c] + H+[c] YDR248C 0.00 1000.00 0.00 +r_4232 ATP[c] + D-gluconate[c] <=> 6-phospho-D-gluconate[c] + ADP[c] + H+[c] YDR248C -1000.00 1000.00 0.00 r_4233 S-adenosyl-L-methionine[c] + Protein C-terminal S-farnesyl-L-cysteine[c] <=> S-adenosyl-L-homocysteine[c] + Protein C-terminal S-farnesyl-L-cysteine methyl ester[c] YDR410C -1000.00 1000.00 0.00 r_4234 UDP-N-acetyl-alpha-D-glucosamine[er] + 1-phosphatidyl-1D-myo-inositol[er] <=> H+[er] + UDP[er] + G00143[er] YDR437W and YGR216C and YNL038W and YPL076W and YPL175W and YPL096C-A -1000.00 1000.00 0.00 r_4236 (R)-lactate[c] + H+[c] <=> H2O[c] + methylglyoxal[c] YDR533C or YMR322C or YOR391C or YPL280W -1000.00 1000.00 0.00 @@ -3730,7 +3730,7 @@ r_4368 H2O[c] + O(4)-phospho-L-tyrosine[c] => L-tyrosine[c] + phosphate[c] 0 r_4369 H+[e] + triphosphate[e] <=> H+[c] + triphosphate[c] -1000.00 1000.00 0.00 r_4370 H2O[c] + cytidine 2'-phosphate[c] => cytidine[c] + phosphate[c] 0.00 1000.00 0.00 r_4371 H+[e] + cytidine 2'-phosphate[e] <=> H+[c] + cytidine 2'-phosphate[c] -1000.00 1000.00 0.00 -r_4372 H2O[c] + 2',3'-cyclic UMP[c] => H+[c] + uridine 2'-phosphate[c] 0.00 1000.00 0.00 +r_4372 H2O[c] + 2',3'-cyclic UMP[c] => H+[c] + uridine 2'-phosphate[c] YGR247W 0.00 1000.00 0.00 r_4373 H+[e] + 2',3'-cyclic UMP[e] <=> H+[c] + 2',3'-cyclic UMP[c] -1000.00 1000.00 0.00 r_4374 H2O[c] + 3-sulfino-L-alanine[c] => H+[c] + L-alanine[c] + sulphite[c] 0.00 1000.00 0.00 r_4375 H+[e] + 3-sulfino-L-alanine[e] <=> H+[c] + 3-sulfino-L-alanine[c] -1000.00 1000.00 0.00 @@ -3746,7 +3746,7 @@ r_4384 H+[c] + NADPH[c] + 5-dehydro-D-gluconate[c] => NADP(+)[c] + D-gluconate[c r_4385 H+[e] + 5-dehydro-D-gluconate[e] <=> H+[c] + 5-dehydro-D-gluconate[c] -1000.00 1000.00 0.00 r_4386 H2O[v] + Ala-Asp[v] => L-aspartate[v] + L-alanine[v] 0.00 1000.00 0.00 r_4387 H+[e] + Ala-Asp[e] <=> H+[c] + Ala-Asp[c] YJR152W or YKR093W -1000.00 1000.00 0.00 -r_4388 H2O[c] + 2',3'-cyclic CMP[c] => H+[c] + cytidine 2'-phosphate[c] 0.00 1000.00 0.00 +r_4388 H2O[c] + 2',3'-cyclic CMP[c] => H+[c] + cytidine 2'-phosphate[c] YGR247W 0.00 1000.00 0.00 r_4389 H+[e] + 2',3'-cyclic CMP[e] <=> H+[c] + 2',3'-cyclic CMP[c] -1000.00 1000.00 0.00 r_4390 H2O[c] + methyl alpha-D-glucopyranoside[c] <=> D-glucose[c] + methanol[c] -1000.00 1000.00 0.00 r_4391 methanol[c] => methanol[e] 0.00 1000.00 0.00 @@ -3758,7 +3758,7 @@ r_4396 ATP[c] + coenzyme A[c] + acetoacetate[c] => acetoacetyl-CoA[c] + AMP[c] + r_4397 H2O[c] + N(alpha)-acetyl-L-methionine[c] <=> acetate[c] + L-methionine[c] -1000.00 1000.00 0.00 r_4398 H+[e] + Ala-Gln[e] <=> H+[c] + Ala-Gln[c] YJR152W or YKR093W -1000.00 1000.00 0.00 r_4399 H+[c] + Ala-Glu[c] <=> H+[v] + Ala-Glu[v] -1000.00 1000.00 0.00 -r_4400 H2O[e] + alpha-maltotriose[e] => D-glucose[e] + maltose[e] 0.00 1000.00 0.00 +r_4400 H2O[e] + alpha-maltotriose[e] => D-glucose[e] + maltose[e] YBR299W or YGR292W 0.00 1000.00 0.00 r_4401 H+[c] + Ala-Thr[c] <=> H+[v] + Ala-Thr[v] -1000.00 1000.00 0.00 r_4402 H+[e] + Ala-Thr[e] <=> H+[c] + Ala-Thr[c] YJR152W or YKR093W -1000.00 1000.00 0.00 r_4403 H2O[c] + triphosphate[c] => diphosphate[c] + phosphate[c] YHR201C or YDR452W 0.00 1000.00 0.00 @@ -3770,7 +3770,7 @@ r_4408 H+[e] + Ala-Glu[e] <=> H+[c] + Ala-Glu[c] YJR152W or YKR093W -1000.00 10 r_4409 H2O[v] + Ala-Glu[v] => L-glutamate[v] + L-alanine[v] 0.00 1000.00 0.00 r_4410 3-oxalomalate(3-)[c] <=> glyoxylate[c] + oxaloacetate[c] -1000.00 1000.00 0.00 r_4411 H2O[c] + L-cysteate[c] => ammonium[c] + H+[c] + pyruvate[c] + sulphite[c] 0.00 1000.00 0.00 -r_4412 H2O[c] + 2',3'-cyclic GMP[c] => H+[c] + guanosine 2'-monophosphate[c] 0.00 1000.00 0.00 +r_4412 H2O[c] + 2',3'-cyclic GMP[c] => H+[c] + guanosine 2'-monophosphate[c] YGR247W 0.00 1000.00 0.00 r_4413 H2O[c] + thymidine 3'-monophosphate[c] => phosphate[c] + thymidine[c] 0.00 1000.00 0.00 r_4414 H2O[v] + Ala-Gln[v] => L-glutamine[v] + L-alanine[v] 0.00 1000.00 0.00 r_4415 H2O[v] + Ala-His[v] => L-histidine[v] + L-alanine[v] 0.00 1000.00 0.00 @@ -3778,7 +3778,7 @@ r_4416 H2O[v] + Ala-Thr[v] => L-alanine[v] + L-threonine[v] 0.00 1000.00 0 r_4417 H2O[v] + Gly-Asn[v] => L-asparagine[v] + L-glycine[v] 0.00 1000.00 0.00 r_4418 H2O[v] + Gly-Gln[v] => L-glutamine[v] + L-glycine[v] 0.00 1000.00 0.00 r_4419 H+[e] + L-cysteate[e] <=> H+[c] + L-cysteate[c] -1000.00 1000.00 0.00 -r_4420 H2O[e] + turanose[e] <=> D-fructose[e] + D-glucose[e] -1000.00 1000.00 0.00 +r_4420 H2O[e] + turanose[e] <=> D-fructose[e] + D-glucose[e] YBR299W or YGR292W -1000.00 1000.00 0.00 r_4421 H+[e] + 2-hydroxyethane-1-sulfonate[e] <=> H+[c] + 2-hydroxyethane-1-sulfonate[c] -1000.00 1000.00 0.00 r_4422 H+[e] + 3-oxalomalate(3-)[e] <=> H+[c] + 3-oxalomalate(3-)[c] -1000.00 1000.00 0.00 r_4423 H+[c] + Gly-Met[c] <=> H+[v] + Gly-Met[v] -1000.00 1000.00 0.00 @@ -3924,25 +3924,19 @@ r_4562 uridine 2'-phosphate[e] => 0.00 1000.00 0.00 r_4563 3'-UMP[e] => 0.00 1000.00 0.00 r_4564 2',3'-cyclic CMP[e] => 0.00 1000.00 0.00 r_4565 2',3'-cyclic UMP[e] => 0.00 1000.00 0.00 -r_4566 6-phospho-D-gluconate[c] + ADP[c] + H+[c] => ATP[c] + D-gluconate[c] 0.00 1000.00 0.00 r_4567 6-phospho-D-gluconate[c] + H2O[c] => phosphate[c] + D-gluconate[c] 0.00 1000.00 0.00 r_4568 H+[c] + phenylacetic acid[c] => 4-hydroxyphenyl acetate[c] 0.00 1000.00 0.00 r_4569 acetate[c] + H+[c] + Hydroquinone[c] => H2O[c] + 4-hydroxyphenyl acetate[c] 0.00 1000.00 0.00 -r_4570 NAD[c] + 2-hydroxyglutarate[c] <=> 2-oxoglutarate[c] + H+[c] + NADH[c] -1000.00 1000.00 0.00 +r_4570 NAD[c] + 2-hydroxyglutarate[c] <=> 2-oxoglutarate[c] + H+[c] + NADH[c] YIL074C or YER081W -1000.00 1000.00 0.00 r_4571 coenzyme A[c] + H+[c] + 2-hydroxyglutarate[c] <=> glyoxylate[c] + H2O[c] + propionyl-CoA[c] -1000.00 1000.00 0.00 r_4572 2-oxoglutarate[c] + beta-alanine[c] <=> L-glutamate[c] + 3-oxopropanoate[c] -1000.00 1000.00 0.00 r_4573 coenzyme A[c] + NAD[c] + 3-oxopropanoate[c] => acetyl-CoA[c] + carbon dioxide[c] + NADH[c] 0.00 1000.00 0.00 r_4574 coenzyme A[c] + NADP(+)[c] + 3-oxopropanoate[c] => acetyl-CoA[c] + carbon dioxide[c] + NADPH[c] 0.00 1000.00 0.00 r_4575 H+[c] + 3-oxopropanoate[c] => acetaldehyde[c] + carbon dioxide[c] 0.00 1000.00 0.00 -r_4576 NADP(+)[c] + (R)-2,3-dihydroxy-3-methylbutanoate[c] <=> H+[c] + NADPH[c] + 3-hydroxy-3-methyl-2-oxobutanoate[c] -1000.00 1000.00 0.00 -r_4577 3-methyl-2-oxobutanoate[c] + H2O[c] => 2,3-dihydroxy-3-methylbutanoate[c] 0.00 1000.00 0.00 -r_4578 H+[c] + NADPH[c] + 2-acetyllactic acid[c] => NADP(+)[c] + (R)-2,3-dihydroxy-3-methylbutanoate[c] 0.00 1000.00 0.00 -r_4579 H+[c] + 2 pyruvate[c] => carbon dioxide[c] + (2S)-2-acetolactate[c] 0.00 1000.00 0.00 -r_4580 NADP(+)[c] + (R)-2,3-dihydroxy-3-methylbutanoate[c] <=> H+[c] + NADPH[c] + (2S)-2-acetolactate[c] -1000.00 1000.00 0.00 r_4581 NAD[c] + (2R,3S)-3-methylmalate[c] => 2-oxobutanoate[c] + carbon dioxide[c] + NADH[c] 0.00 1000.00 0.00 r_4582 glyoxylate[c] + H2O[c] + propionyl-CoA[c] => coenzyme A[c] + H+[c] + (2R,3S)-3-methylmalate[c] 0.00 1000.00 0.00 r_4583 H2O[c] + trans-2,cis-9-octadecadienoyl-CoA[c] => coenzyme A[c] + H+[c] + (9Z,12Z)-octadecadienoate[c] 0.00 1000.00 0.00 -r_4584 ATP[c] + coenzyme A[c] + (9Z,12Z)-octadecadienoate[c] => AMP[c] + diphosphate[c] + trans-2,cis-9-octadecadienoyl-CoA[c] 0.00 1000.00 0.00 +r_4584 ATP[c] + coenzyme A[c] + (9Z,12Z)-octadecadienoate[c] => AMP[c] + diphosphate[c] + trans-2,cis-9-octadecadienoyl-CoA[c] YOR317W or YER015W or YMR246W or YIL009W 0.00 1000.00 0.00 r_4585 H2O[c] + stachyose[c] => D-galactose[c] + raffinose[c] 0.00 1000.00 0.00 r_4586 sucrose[c] + stachyose[c] => 2 raffinose[c] 0.00 1000.00 0.00 r_4587 H+[e] + Ca(2+)[e] <=> H+[c] + Ca(2+)[c] YOL122C -1000.00 1000.00 0.00 @@ -4055,7 +4049,7 @@ r_4693 acetyl-CoA[c] + propanol[c] => coenzyme A[c] + propyl acetate[c] YGR177C r_4694 propyl acetate[c] => propyl acetate[e] 0.00 1000.00 0.00 r_4695 propyl acetate[e] => 0.00 1000.00 0.00 r_4697 ethyl propionate[m] <=> ethyl propionate[c] -1000.00 1000.00 0.00 -r_4698 ethyl propionate[c] => ethyl propionate[e] 0.00 1000.00 0.00 +r_4698 ethyl propionate[c] => ethyl propionate[e] YNL065W or YKL217W 0.00 1000.00 0.00 r_4699 ethyl propionate[e] => 0.00 1000.00 0.00 r_4700 hydrogen sulfide[c] => hydrogen sulfide[e] YIL166C 0.00 1000.00 0.00 r_4701 H2O[m] + L-cysteine[m] <=> ammonium[m] + pyruvate[m] + hydrogen sulfide[m] YFR055W -1000.00 1000.00 0.00 diff --git a/model/yeast-GEM.xlsx b/model/yeast-GEM.xlsx deleted file mode 100644 index b4b0f38f..00000000 Binary files a/model/yeast-GEM.xlsx and /dev/null differ diff --git a/model/yeast-GEM.xml b/model/yeast-GEM.xml old mode 100755 new mode 100644 index 0983c70b..45be28ed --- a/model/yeast-GEM.xml +++ b/model/yeast-GEM.xml @@ -1,6 +1,6 @@ - +

Saccharomyces cerevisiae - strain S288C

@@ -8,7 +8,7 @@ - + @@ -39517,69 +39517,6 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - @@ -39873,21 +39810,6 @@ - - - - - - - - - - - - - - - @@ -40917,11 +40839,17 @@ - - + - + + + + + + + + @@ -41385,7 +41313,6 @@ - @@ -41432,7 +41359,6 @@ - @@ -49509,16 +49435,11 @@ - - - - - - - - - - + + + + + @@ -49556,16 +49477,11 @@ - - - - - - - - - - + + + + + @@ -49601,16 +49517,11 @@ - - - - - - - - - - + + + + + @@ -49648,16 +49559,11 @@ - - - - - - - - - - + + + + + @@ -56499,7 +56405,6 @@ - @@ -65451,11 +65356,19 @@ - - - - - + + + + + + + + + + + + + @@ -65503,11 +65416,19 @@ - - - - - + + + + + + + + + + + + + @@ -66221,13 +66142,10 @@ - + + - - - - - + @@ -66269,13 +66187,10 @@ - + + - - - - - + @@ -66690,22 +66605,11 @@ - - - - - - - - - - - - - - + - + + + @@ -67685,11 +67589,7 @@ - - - - - + @@ -68237,7 +68137,6 @@ - @@ -68998,7 +68897,6 @@ - @@ -69227,17 +69125,11 @@ - - - - - - - - - - - + + + + + @@ -69277,17 +69169,14 @@ - - - - - - - - - - - + + + + + + + + @@ -72106,21 +71995,43 @@ - - - - - - - - - - - - - - - + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + @@ -72157,21 +72068,43 @@ - - - - - - - - - - - - - - - + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + @@ -72525,6 +72458,12 @@ + + + + + + @@ -72842,7 +72781,6 @@ - @@ -73642,7 +73580,6 @@ - @@ -73768,17 +73705,15 @@ + - - - @@ -74420,7 +74355,6 @@ - @@ -74629,11 +74563,8 @@ - - - @@ -75803,9 +75734,7 @@ - - @@ -76382,10 +76311,7 @@ - - - - + @@ -78919,6 +78845,12 @@ + + + + + + @@ -79501,6 +79433,12 @@ + + + + + + @@ -79529,6 +79467,12 @@ + + + + + + @@ -79557,6 +79501,12 @@ + + + + + + @@ -79585,6 +79535,12 @@ + + + + + + @@ -81382,6 +81338,9 @@ + + + @@ -81410,6 +81369,9 @@ + + + @@ -82196,6 +82158,9 @@ + + + @@ -82779,6 +82744,9 @@ + + + @@ -82896,6 +82864,9 @@ + + + @@ -83297,10 +83268,7 @@ - - - - + @@ -83973,6 +83941,9 @@ + + + @@ -83997,6 +83968,9 @@ + + + @@ -85647,12 +85621,10 @@ - - @@ -86813,6 +86785,9 @@ + + + @@ -87416,6 +87391,9 @@ + + + @@ -91353,6 +91331,9 @@ + + + @@ -91481,6 +91462,9 @@ + + + @@ -113336,10 +113320,25 @@ - - - - + + + + + + + + + + + + + + + + + + + @@ -113377,10 +113376,25 @@ - - - - + + + + + + + + + + + + + + + + + + + @@ -113418,10 +113432,25 @@ - - - - + + + + + + + + + + + + + + + + + + + @@ -113459,10 +113488,25 @@ - - - - + + + + + + + + + + + + + + + + + + + @@ -113500,10 +113544,25 @@ - - - - + + + + + + + + + + + + + + + + + + + @@ -113541,10 +113600,25 @@ - - - - + + + + + + + + + + + + + + + + + + + @@ -113582,10 +113656,25 @@ - - - - + + + + + + + + + + + + + + + + + + + @@ -113623,10 +113712,25 @@ - - - - + + + + + + + + + + + + + + + + + + + @@ -125366,8 +125470,11 @@ - + + + + @@ -125401,8 +125508,11 @@ - + + + + @@ -125436,8 +125546,11 @@ - + + + + @@ -125471,8 +125584,11 @@ - + + + + @@ -125506,8 +125622,11 @@ - + + + + @@ -125541,8 +125660,11 @@ - + + + + @@ -125576,8 +125698,11 @@ - + + + + @@ -125611,8 +125736,11 @@ - + + + + @@ -145442,7 +145570,6 @@ - @@ -150748,10 +150875,7 @@ - - - - + @@ -150777,10 +150901,7 @@ - - - - + @@ -152780,7 +152901,7 @@ - +

Confidence Level: 2

@@ -157135,6 +157256,9 @@ + + + @@ -157587,6 +157711,9 @@ + + + @@ -157944,6 +158071,12 @@ + + + + + + @@ -158295,6 +158428,9 @@ + + + @@ -158518,6 +158654,12 @@ + + + + + + @@ -162021,36 +162163,6 @@ - - - -

Confidence Level: 0

-

NOTES: metabolites observed in metabolomics data (PR #156)

- - - - - - - - - - - - - - - - - - - - - - - - - @@ -162168,6 +162280,12 @@ + + + + + + @@ -162324,153 +162442,6 @@ - - - -

Confidence Level: 0

-

NOTES: metabolites observed in metabolomics data (PR #156)

- - - - - - - - - - - - - - - - - - - - - - - - - - - - -

Confidence Level: 0

-

NOTES: metabolites observed in metabolomics data (PR #156) | MetaNetX ID curated (PR #220) | KEGG ID curated (PR #220)

- - - - - - - - - - - - - - - - - - - - - - - - - -

Confidence Level: 0

-

NOTES: metabolites observed in metabolomics data (PR #156) | model.S(2671,3939) curated (PR #222) | model.S(2670,3939) curated (PR #222) | model.S(601,3939) curated (PR #222)

- - - - - - - - - - - - - - - - - - - - - - - - - - -

Confidence Level: 0

-

NOTES: metabolites observed in metabolomics data (PR #156)

- - - - - - - - - - - - - - - - - - - - - - - - - - - - -

Confidence Level: 0

-

NOTES: metabolites observed in metabolomics data (PR #156)

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metaData: - id: "yeastGEM_v8.6.0" + id: "yeastGEM_develop" name: "The Consensus Genome-Scale Metabolic Model of Yeast" - date: "2022-05-18" + date: "2022-06-15" givenName: "Eduard" familyName: "Kerkhoven" email: "eduardk@chalmers.se" @@ -29060,53 +29060,6 @@ - kegg.compound: "C00222" - metanetx.chemical: "MNXM244" - sbo: "SBO:0000247" - - !!omap - - id: "s_4185" - - name: "(R)-2,3-dihydroxy-3-methylbutanoate" - - compartment: "c" - - formula: "C5H9O4" - - charge: -1 - - annotation: !!omap - - bigg.metabolite: "23dhmb" - - chebi: "CHEBI:49072" - - kegg.compound: "C04272" - - metanetx.chemical: "MNXM114097" - - sbo: "SBO:0000247" - - !!omap - - id: "s_4186" - - name: "3-hydroxy-3-methyl-2-oxobutanoate" - - compartment: "c" - - formula: "C5H7O4" - - charge: -1 - - annotation: !!omap - - bigg.metabolite: "3hmoa" - - chebi: "CHEBI:11812" - - kegg.compound: "C04181" - - metanetx.chemical: "MNXM1638" - - sbo: "SBO:0000247" - - !!omap - - id: "s_4187" - - name: "2-acetyllactic acid" - - compartment: "c" - - formula: "C5H7O4" - - charge: -1 - - annotation: !!omap - - chebi: "CHEBI:57774" - - kegg.compound: "C00900" - - metanetx.chemical: "MNXM426" - - sbo: "SBO:0000247" - - !!omap - - id: "s_4188" - - name: "(2S)-2-acetolactate" - - compartment: "c" - - formula: "C5H7O4" - - charge: -1 - - annotation: !!omap - - bigg.metabolite: "alac__S" - - chebi: "CHEBI:58476" - - kegg.compound: "C06010" - - metanetx.chemical: "MNXM114079" - - sbo: "SBO:0000247" - !!omap - id: "s_4189" - name: "(2R,3S)-3-methylmalate" @@ -29322,17 +29275,6 @@ - kegg.compound: "C01157" - metanetx.chemical: "MNXM87584" - sbo: "SBO:0000247" - - !!omap - - id: "s_4208" - - name: "2,3-dihydroxy-3-methylbutanoate" - - compartment: "c" - - formula: "C5H9O4" - - charge: -1 - - annotation: !!omap - - chebi: "CHEBI:11424" - - kegg.compound: "C04039" - - metanetx.chemical: "MNXM734" - - sbo: "SBO:0000247" - !!omap - id: "s_4209" - name: "Ferrocytochrome b5" @@ -29921,6 +29863,7 @@ - "1.1.2.4" - "1.1.99.-" - subsystem: + - "Pyruvate metabolism" - annotation: !!omap - bigg.reaction: "D_LACDcm" - kegg.pathway: @@ -29945,6 +29888,7 @@ - "1.1.2.4" - "1.1.99.-" - subsystem: + - "Pyruvate metabolism" - annotation: !!omap - bigg.reaction: "D_LACDm" - kegg.pathway: @@ -29968,6 +29912,7 @@ - gene_reaction_rule: "YAL060W" - eccodes: "1.1.1.4" - subsystem: + - "Butanoate metabolism" - annotation: !!omap - bigg.reaction: "BTDD_RR" - kegg.pathway: "sce00650" @@ -29988,6 +29933,7 @@ - gene_reaction_rule: "(YEL039C and YML054C) or (YJR048W and YML054C)" - eccodes: "1.1.2.3" - subsystem: + - "Pyruvate metabolism" - annotation: !!omap - bigg.reaction: "L_LACD2cm" - kegg.pathway: @@ -30007,9 +29953,10 @@ - s_1543: -1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "YGR032W or YMR306W or (YLR342W and YCR034W)" + - gene_reaction_rule: "(YPR165W and YLR342W) or (YPR165W and YGR032W) or (YPR165W and YMR306W)" - eccodes: "2.4.1.34" - subsystem: + - "Starch and sucrose metabolism" - annotation: !!omap - kegg.pathway: - "sce00500" @@ -30031,6 +29978,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YGR143W or YPR159W" - subsystem: + - "Starch and sucrose metabolism" - annotation: !!omap - pubmed: "8321211" - sbo: "SBO:0000176" @@ -30046,6 +29994,7 @@ - gene_reaction_rule: "YIL020C" - eccodes: "5.3.1.16" - subsystem: + - "Histidine metabolism" - annotation: !!omap - bigg.reaction: "PRMICI" - kegg.pathway: @@ -30071,6 +30020,7 @@ - gene_reaction_rule: "YHR037W" - eccodes: "1.2.1.88" - subsystem: + - "Alanine, aspartate and glutamate metabolism" - annotation: !!omap - bigg.reaction: "P5CDm" - kegg.pathway: @@ -30098,6 +30048,7 @@ - "1.13.11.54" - "3.1.3.77" - subsystem: + - "Cysteine and methionine metabolism" - annotation: !!omap - kegg.pathway: "sce00270" - pubmed: "14506228" @@ -30119,6 +30070,7 @@ - "3.5.4.26" - "5.4.99.28" - subsystem: + - "Riboflavin metabolism" - annotation: !!omap - bigg.reaction: "DRTPPD" - kegg.pathway: "sce00740" @@ -30141,6 +30093,7 @@ - gene_reaction_rule: "YBR153W" - eccodes: "1.1.1.302" - subsystem: + - "Riboflavin metabolism" - annotation: !!omap - kegg.pathway: "sce00740" - kegg.reaction: "R09376" @@ -30162,6 +30115,7 @@ - gene_reaction_rule: "(YCL009C and YMR108W) or YMR108W" - eccodes: "2.2.1.6" - subsystem: + - "Valine, leucine and isoleucine metabolism" - annotation: !!omap - bigg.reaction: "ACHBSm" - kegg.pathway: @@ -30195,6 +30149,7 @@ - "2.7.6.3" - "4.1.2.25" - subsystem: + - "Folate biosynthesis" - annotation: !!omap - kegg.pathway: "sce00790" - kegg.reaction: "R03503" @@ -30217,6 +30172,7 @@ - "2.6.1.57" - "2.6.1.7" - subsystem: + - "Lysine metabolism" - annotation: !!omap - bigg.reaction: "AATA" - kegg.pathway: @@ -30252,6 +30208,7 @@ - gene_reaction_rule: "YHR063C" - eccodes: "1.1.1.169" - subsystem: + - "Pantothenate and coa biosynthesis" - annotation: !!omap - bigg.reaction: "DPR" - kegg.pathway: @@ -30275,6 +30232,7 @@ - gene_reaction_rule: "YDR035W or YBR249C" - eccodes: "2.5.1.54" - subsystem: + - "Phenylalanine, tyrosine and tryptophan biosynthesis" - annotation: !!omap - bigg.reaction: "DDPAm" - kegg.pathway: @@ -30297,7 +30255,7 @@ - s_1419: -1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "YDR204W and YGL119W and YGR255C and YLR201C and YML110C and YOL096C and YOR125C" + - gene_reaction_rule: "YDR204W and YGR255C and YLR201C and YML110C and YOL096C and YOR125C" - eccodes: - "1.14.13.-" - "2.1.1.114" @@ -30305,6 +30263,7 @@ - "2.1.1.64" - "2.7.-.-" - subsystem: + - "Ubiquinone and other terpenoid-quinone biosynthesis" - annotation: !!omap - bigg.reaction: "2HPMBQMTm" - kegg.pathway: @@ -30325,7 +30284,7 @@ - s_1278: -1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "YDR204W and YGL119W and YGR255C and YLR201C and YML110C and YOL096C and YOR125C" + - gene_reaction_rule: "YDR204W and YGR255C and YLR201C and YML110C and YOL096C and YOR125C" - eccodes: - "1.14.13.-" - "2.1.1.114" @@ -30333,6 +30292,7 @@ - "2.1.1.64" - "2.7.-.-" - subsystem: + - "Ubiquinone and other terpenoid-quinone biosynthesis" - annotation: !!omap - bigg.reaction: "2HP6MPMOm" - kegg.pathway: @@ -30355,6 +30315,7 @@ - gene_reaction_rule: "YGL009C" - eccodes: "4.2.1.33" - subsystem: + - "Valine, leucine and isoleucine metabolism" - annotation: !!omap - bigg.reaction: "IPPMIb" - kegg.pathway: @@ -30382,6 +30343,7 @@ - gene_reaction_rule: "YNL104C or YOR108W" - eccodes: "2.3.3.13" - subsystem: + - "Valine, leucine and isoleucine metabolism" - annotation: !!omap - bigg.reaction: "IPPS" - kegg.pathway: @@ -30410,6 +30372,7 @@ - gene_reaction_rule: "YNL104C" - eccodes: "2.3.3.13" - subsystem: + - "Valine, leucine and isoleucine metabolism" - annotation: !!omap - bigg.reaction: "IPPSm" - kegg.pathway: @@ -30435,6 +30398,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YHR208W or YJR148W or YGL202W or YHR137W" - subsystem: + - "Cysteine and methionine metabolism" - annotation: !!omap - kegg.reaction: "R07396" - metanetx.reaction: "MNXR95923" @@ -30453,6 +30417,7 @@ - gene_reaction_rule: "YDR234W" - eccodes: "4.2.1.36" - subsystem: + - "Lysine metabolism" - annotation: !!omap - kegg.pathway: - "sce00300" @@ -30479,6 +30444,7 @@ - gene_reaction_rule: "YPR001W" - eccodes: "2.3.3.1" - subsystem: + - "Propanoate metabolism" - annotation: !!omap - bigg.reaction: "MCITSm" - kegg.pathway: @@ -30507,6 +30473,7 @@ - gene_reaction_rule: "YJR148W" - eccodes: "2.6.1.42" - subsystem: + - "Valine, leucine and isoleucine metabolism" - annotation: !!omap - bigg.reaction: "OMCDC" - kegg.pathway: @@ -30535,6 +30502,7 @@ - gene_reaction_rule: "YHR208W" - eccodes: "2.6.1.42" - subsystem: + - "Valine, leucine and isoleucine metabolism" - annotation: !!omap - bigg.reaction: "OMCDCm" - kegg.pathway: @@ -30563,6 +30531,7 @@ - gene_reaction_rule: "YOL064C" - eccodes: "3.1.3.7" - subsystem: + - "Sulfur metabolism" - annotation: !!omap - bigg.reaction: "BPNT" - kegg.pathway: @@ -30588,6 +30557,7 @@ - "3.1.4.17" - "3.1.4.53" - subsystem: + - "Purine metabolism" - annotation: !!omap - bigg.reaction: "PDE1" - kegg.pathway: "sce00230" @@ -30608,6 +30578,7 @@ - gene_reaction_rule: "YOR360C" - eccodes: "3.1.4.53" - subsystem: + - "Purine metabolism" - annotation: !!omap - bigg.reaction: "PDE2" - kegg.pathway: "sce00230" @@ -30627,6 +30598,7 @@ - gene_reaction_rule: "YOR360C" - eccodes: "3.1.4.53" - subsystem: + - "Purine metabolism" - annotation: !!omap - bigg.reaction: "PDE3" - kegg.pathway: "sce00230" @@ -30646,6 +30618,7 @@ - gene_reaction_rule: "YOR360C" - eccodes: "3.1.4.53" - subsystem: + - "Purine metabolism" - annotation: !!omap - bigg.reaction: "PDE4" - kegg.pathway: "sce00230" @@ -30666,6 +30639,7 @@ - gene_reaction_rule: "YOR360C" - eccodes: "3.1.4.53" - subsystem: + - "Purine metabolism" - annotation: !!omap - bigg.reaction: "PDE5" - kegg.pathway: "sce00230" @@ -30685,6 +30659,7 @@ - gene_reaction_rule: "YDR487C" - eccodes: "4.1.99.12" - subsystem: + - "Riboflavin metabolism" - annotation: !!omap - bigg.reaction: "DB4PS" - kegg.pathway: @@ -30712,6 +30687,7 @@ - "4.2.1.10" - "4.2.3.4" - subsystem: + - "Phenylalanine, tyrosine and tryptophan biosynthesis" - annotation: !!omap - bigg.reaction: "DHQTi" - kegg.pathway: @@ -30740,6 +30716,7 @@ - "4.2.1.10" - "4.2.3.4" - subsystem: + - "Phenylalanine, tyrosine and tryptophan biosynthesis" - annotation: !!omap - bigg.reaction: "DHQS" - kegg.pathway: @@ -30766,6 +30743,7 @@ - gene_reaction_rule: "YBR265W" - eccodes: "1.1.1.102" - subsystem: + - "Sphingolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00600" - kegg.reaction: "R02978" @@ -30789,6 +30767,7 @@ - gene_reaction_rule: "YBR249C or YDR035W" - eccodes: "2.5.1.54" - subsystem: + - "Phenylalanine, tyrosine and tryptophan biosynthesis" - annotation: !!omap - bigg.reaction: "DDPA" - kegg.pathway: @@ -30812,6 +30791,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YPL252C or YDR376W" - subsystem: + - "Ubiquinone and other terpenoid-quinone biosynthesis" - annotation: !!omap - bigg.reaction: "3OPHB5Hm" - kegg.reaction: "R06865" @@ -30831,6 +30811,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YDR538W and YDR539W" - subsystem: + - "Ubiquinone and other terpenoid-quinone biosynthesis" - annotation: !!omap - kegg.reaction: "R06866" - metanetx.reaction: "MNXR94901" @@ -30851,6 +30832,7 @@ - gene_reaction_rule: "YLR231C" - eccodes: "3.7.1.3" - subsystem: + - "Tryptophan metabolism" - annotation: !!omap - bigg.reaction: "HKYNH" - kegg.pathway: "sce00380" @@ -30874,6 +30856,7 @@ - "1.1.1.n12" - "4.2.1.119" - subsystem: + - "Fatty acid degradation" - annotation: !!omap - bigg.reaction: "HACD6p" - kegg.reaction: "R04739" @@ -30892,6 +30875,7 @@ - gene_reaction_rule: "YJR025C" - eccodes: "1.13.11.6" - subsystem: + - "Tryptophan metabolism" - annotation: !!omap - bigg.reaction: "3HAO" - kegg.pathway: "sce00380" @@ -30913,6 +30897,7 @@ - gene_reaction_rule: "YER175C" - eccodes: "2.1.1.145" - subsystem: + - "Complex alcohol metabolism" - annotation: !!omap - pubmed: "15147181" - sbo: "SBO:0000176" @@ -30929,6 +30914,7 @@ - gene_reaction_rule: "YGL009C" - eccodes: "4.2.1.33" - subsystem: + - "Valine, leucine and isoleucine metabolism" - annotation: !!omap - bigg.reaction: "IPPMIa" - kegg.pathway: @@ -30955,6 +30941,7 @@ - gene_reaction_rule: "YCL018W" - eccodes: "1.1.1.85" - subsystem: + - "Valine, leucine and isoleucine metabolism" - annotation: !!omap - bigg.reaction: "IPMD" - kegg.pathway: @@ -30985,6 +30972,7 @@ - "4.1.1.43" - "4.1.1.74" - subsystem: + - "Complex alcohol metabolism" - annotation: !!omap - bigg.reaction: "3MOBDC" - kegg.pathway: @@ -31009,6 +30997,7 @@ - gene_reaction_rule: "YBR176W" - eccodes: "2.1.2.11" - subsystem: + - "Pantothenate and coa biosynthesis" - annotation: !!omap - bigg.reaction: "MTMOHT" - kegg.pathway: @@ -31035,6 +31024,7 @@ - "4.1.1.43" - "4.1.1.74" - subsystem: + - "Complex alcohol metabolism" - annotation: !!omap - bigg.reaction: "3MOPDC" - kegg.pathway: @@ -31064,6 +31054,7 @@ - "4.2.1.10" - "4.2.3.4" - subsystem: + - "Phenylalanine, tyrosine and tryptophan biosynthesis" - annotation: !!omap - bigg.reaction: "PSCVT" - kegg.pathway: @@ -31089,6 +31080,7 @@ - gene_reaction_rule: "YNR033W" - eccodes: "2.6.1.85" - subsystem: + - "Folate biosynthesis" - annotation: !!omap - bigg.reaction: "ADCS" - kegg.pathway: "sce00790" @@ -31109,6 +31101,7 @@ - gene_reaction_rule: "YMR289W" - eccodes: "4.1.3.38" - subsystem: + - "Folate biosynthesis" - annotation: !!omap - bigg.reaction: "ADCL" - kegg.reaction: "R05553" @@ -31128,6 +31121,7 @@ - gene_reaction_rule: "YGR019W" - eccodes: "2.6.1.19" - subsystem: + - "Alanine, aspartate and glutamate metabolism" - annotation: !!omap - bigg.reaction: "ABTA" - kegg.pathway: @@ -31154,6 +31148,7 @@ - gene_reaction_rule: "YCR053W" - eccodes: "4.2.3.1" - subsystem: + - "Vitamin b6 metabolism" - annotation: !!omap - bigg.reaction: "4HTHRS" - kegg.pathway: @@ -31178,6 +31173,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Ubiquinone and other terpenoid-quinone biosynthesis" - annotation: !!omap - bigg.reaction: "4HBZFm" - kegg.reaction: "R01301" @@ -31198,6 +31194,7 @@ - gene_reaction_rule: "YDL080C" - eccodes: "4.1.1.-" - subsystem: + - "Complex alcohol metabolism" - annotation: !!omap - bigg.reaction: "4MOPDC" - kegg.pathway: @@ -31226,6 +31223,7 @@ - "3.6.1.52" - "3.6.1.60" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.reaction: "R05779" - metanetx.reaction: "MNXR103044" @@ -31246,6 +31244,7 @@ - gene_reaction_rule: "YDR017C" - eccodes: "2.7.4.21" - subsystem: + - "Phosphatidylinositol signaling system" - annotation: !!omap - kegg.pathway: - "sce04070" @@ -31266,6 +31265,7 @@ - gene_reaction_rule: "YLR017W" - eccodes: "2.4.2.28" - subsystem: + - "Cysteine and methionine metabolism" - annotation: !!omap - bigg.reaction: "MTAP" - kegg.pathway: "sce00270" @@ -31287,6 +31287,7 @@ - gene_reaction_rule: "YER037W or YGL224C" - eccodes: "3.1.3.-" - subsystem: + - "Nicotinate and nicotinamide metabolism" - annotation: !!omap - bigg.reaction: "NTD4" - kegg.pathway: "sce00760" @@ -31310,6 +31311,7 @@ - gene_reaction_rule: "YOR155C" - eccodes: "3.1.3.99" - subsystem: + - "Purine metabolism" - annotation: !!omap - bigg.reaction: "NTD11" - kegg.pathway: @@ -31333,6 +31335,7 @@ - gene_reaction_rule: "YER037W or YGL224C" - eccodes: "3.1.3.-" - subsystem: + - "Nicotinate and nicotinamide metabolism" - annotation: !!omap - bigg.reaction: "NTD2" - kegg.pathway: "sce00760" @@ -31361,6 +31364,7 @@ - gene_reaction_rule: "YGR061C" - eccodes: "6.3.5.3" - subsystem: + - "Purine metabolism" - annotation: !!omap - bigg.reaction: "PRFGS" - kegg.pathway: @@ -31385,6 +31389,7 @@ - gene_reaction_rule: "YGL125W or YPL023C" - eccodes: "1.5.1.20" - subsystem: + - "One carbon pool by folate" - annotation: !!omap - bigg.reaction: "MTHFR3" - kegg.pathway: @@ -31410,6 +31415,7 @@ - gene_reaction_rule: "YDR232W" - eccodes: "2.3.1.37" - subsystem: + - "Porphyrin and chlorophyll metabolism" - annotation: !!omap - bigg.reaction: "ALASm" - kegg.pathway: @@ -31436,6 +31442,7 @@ - "3.6.1.52" - "3.6.1.60" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.reaction: "R05779" - metanetx.reaction: "MNXR103044" @@ -31455,6 +31462,7 @@ - gene_reaction_rule: "YDR017C" - eccodes: "2.7.4.21" - subsystem: + - "Phosphatidylinositol signaling system" - annotation: !!omap - kegg.pathway: - "sce04070" @@ -31478,6 +31486,7 @@ - gene_reaction_rule: "YER183C" - eccodes: "6.3.3.2" - subsystem: + - "One carbon pool by folate" - annotation: !!omap - bigg.reaction: "FTHFCL" - kegg.pathway: "sce00670" @@ -31498,6 +31507,7 @@ - gene_reaction_rule: "YER091C" - eccodes: "2.1.1.14" - subsystem: + - "Cysteine and methionine metabolism" - annotation: !!omap - bigg.reaction: "MHPGLUT" - kegg.pathway: @@ -31521,6 +31531,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YJR024C" - subsystem: + - "Cysteine and methionine metabolism" - annotation: !!omap - bigg.reaction: "MDRPD" - kegg.reaction: "R07392" @@ -31538,6 +31549,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YPR118W" - subsystem: + - "Cysteine and methionine metabolism" - annotation: !!omap - bigg.reaction: "MTRI" - kegg.reaction: "R04420" @@ -31561,6 +31573,7 @@ - "2.7.4.21" - "2.7.4.24" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - pubmed: "17412958" - sbo: "SBO:0000176" @@ -31581,6 +31594,7 @@ - "2.7.4.21" - "2.7.4.24" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - pubmed: "17412958" - sbo: "SBO:0000176" @@ -31599,6 +31613,7 @@ - gene_reaction_rule: "YIL107C or YOL136C" - eccodes: "2.7.1.105" - subsystem: + - "Fructose and mannose metabolism" - annotation: !!omap - bigg.reaction: "PFK26" - kegg.pathway: "sce00051" @@ -31618,6 +31633,7 @@ - gene_reaction_rule: "YGR248W or YHR163W" - eccodes: "3.1.1.31" - subsystem: + - "Pentose phosphate pathway" - annotation: !!omap - bigg.reaction: "PGL" - kegg.pathway: @@ -31648,6 +31664,7 @@ - "3.6.1.52" - "3.6.1.60" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.reaction: "R05779" - metanetx.reaction: "MNXR103044" @@ -31668,6 +31685,7 @@ - gene_reaction_rule: "YDR017C" - eccodes: "2.7.4.21" - subsystem: + - "Phosphatidylinositol signaling system" - annotation: !!omap - kegg.pathway: - "sce04070" @@ -31688,6 +31706,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Biotin metabolism" - annotation: !!omap - kegg.reaction: "R03210" - metanetx.reaction: "MNXR95854" @@ -31709,6 +31728,7 @@ - "4.1.1.43" - "4.1.1.74" - subsystem: + - "Butanoate metabolism" - annotation: !!omap - bigg.reaction: "ACALDCD" - kegg.pathway: @@ -31733,6 +31753,7 @@ - gene_reaction_rule: "YLR355C" - eccodes: "1.1.1.86" - subsystem: + - "Valine, leucine and isoleucine metabolism" - annotation: !!omap - kegg.pathway: - "sce00290" @@ -31757,6 +31778,7 @@ - gene_reaction_rule: "(YCL009C and YMR108W) or YMR108W" - eccodes: "2.2.1.6" - subsystem: + - "Valine, leucine and isoleucine metabolism" - annotation: !!omap - kegg.pathway: - "sce00290" @@ -31784,6 +31806,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YKL192C" - subsystem: + - "Fatty acid biosynthesis" - annotation: !!omap - bigg.reaction: "ACOATAm" - kegg.pathway: "sce00190" @@ -31805,6 +31828,7 @@ - gene_reaction_rule: "YIL160C" - eccodes: "2.3.1.16" - subsystem: + - "Fatty acid degradation" - annotation: !!omap - bigg.reaction: "ACACT8p" - kegg.pathway: @@ -31831,6 +31855,7 @@ - gene_reaction_rule: "YIL160C" - eccodes: "2.3.1.16" - subsystem: + - "Fatty acid degradation" - annotation: !!omap - bigg.reaction: "ACACT9p" - kegg.pathway: @@ -31857,6 +31882,7 @@ - gene_reaction_rule: "YIL160C" - eccodes: "2.3.1.16" - subsystem: + - "Fatty acid degradation" - annotation: !!omap - bigg.reaction: "ACACT7p" - kegg.pathway: @@ -31883,6 +31909,7 @@ - gene_reaction_rule: "YPL028W" - eccodes: "2.3.1.9" - subsystem: + - "Fatty acid degradation" - annotation: !!omap - bigg.reaction: "ACACT1r" - kegg.pathway: @@ -31916,6 +31943,7 @@ - gene_reaction_rule: "YPL028W" - eccodes: "2.3.1.9" - subsystem: + - "Fatty acid degradation" - annotation: !!omap - bigg.reaction: "ACACT1m" - kegg.pathway: @@ -31950,6 +31978,7 @@ - gene_reaction_rule: "YIL160C" - eccodes: "2.3.1.16" - subsystem: + - "Fatty acid degradation" - annotation: !!omap - bigg.reaction: "ACACT6p" - kegg.pathway: @@ -31977,6 +32006,7 @@ - gene_reaction_rule: "YIL160C" - eccodes: "2.3.1.16" - subsystem: + - "Fatty acid degradation" - annotation: !!omap - bigg.reaction: "ACACT4p" - kegg.pathway: @@ -32004,6 +32034,7 @@ - gene_reaction_rule: "YIL160C" - eccodes: "2.3.1.16" - subsystem: + - "Fatty acid degradation" - annotation: !!omap - kegg.pathway: - "sce00071" @@ -32035,6 +32066,7 @@ - "6.3.4.14" - "6.4.1.2" - subsystem: + - "Fatty acid biosynthesis" - annotation: !!omap - bigg.reaction: "ACCOACrm" - kegg.pathway: @@ -32064,6 +32096,7 @@ - gene_reaction_rule: "YDL141W and YNR016C" - eccodes: "6.3.4.14" - subsystem: + - "Fatty acid biosynthesis" - annotation: !!omap - bigg.reaction: "ACCOAC" - kegg.pathway: @@ -32091,6 +32124,7 @@ - gene_reaction_rule: "YBL015W" - eccodes: "3.1.2.1" - subsystem: + - "Pyruvate metabolism" - annotation: !!omap - bigg.reaction: "ACOAHim" - kegg.pathway: "sce00620" @@ -32113,6 +32147,7 @@ - gene_reaction_rule: "YAL054C or YLR153C" - eccodes: "6.2.1.1" - subsystem: + - "Pyruvate metabolism" - annotation: !!omap - bigg.reaction: "ACS" - kegg.pathway: @@ -32142,6 +32177,7 @@ - gene_reaction_rule: "YAL054C" - eccodes: "6.2.1.1" - subsystem: + - "Pyruvate metabolism" - annotation: !!omap - bigg.reaction: "ACSm" - kegg.pathway: @@ -32170,6 +32206,7 @@ - gene_reaction_rule: "YLR153C" - eccodes: "6.2.1.1" - subsystem: + - "Pyruvate metabolism" - annotation: !!omap - kegg.pathway: - "sce00010" @@ -32198,6 +32235,7 @@ - "1.2.1.38" - "2.7.2.8" - subsystem: + - "Arginine biosynthesis" - annotation: !!omap - bigg.reaction: "ACGKm" - kegg.pathway: @@ -32223,6 +32261,7 @@ - gene_reaction_rule: "YBR093C or YAR071W or YBR092C or YHR215W" - eccodes: "3.1.3.2" - subsystem: + - "Riboflavin metabolism" - annotation: !!omap - bigg.reaction: "ACP1e" - kegg.pathway: @@ -32245,6 +32284,7 @@ - gene_reaction_rule: "YPR002W" - eccodes: "4.2.1.79" - subsystem: + - "Propanoate metabolism" - annotation: !!omap - bigg.reaction: "ACONT3m" - kegg.pathway: "sce00640" @@ -32265,6 +32305,7 @@ - gene_reaction_rule: "YOL140W" - eccodes: "2.6.1.11" - subsystem: + - "Arginine biosynthesis" - annotation: !!omap - bigg.reaction: "ACOTAim" - kegg.pathway: @@ -32291,6 +32332,7 @@ - gene_reaction_rule: "YPL148C" - eccodes: "2.7.8.7" - subsystem: + - "Pantothenate and coa biosynthesis" - annotation: !!omap - bigg.reaction: "ACPSm" - kegg.reaction: "R10747" @@ -32310,6 +32352,7 @@ - gene_reaction_rule: "YGL205W" - eccodes: "1.3.3.6" - subsystem: + - "Fatty acid degradation" - annotation: !!omap - kegg.pathway: - "sce00071" @@ -32333,6 +32376,7 @@ - gene_reaction_rule: "YGL205W" - eccodes: "1.3.3.6" - subsystem: + - "Fatty acid degradation" - annotation: !!omap - bigg.reaction: "ACOAO5p" - kegg.pathway: @@ -32357,6 +32401,7 @@ - gene_reaction_rule: "YGL205W" - eccodes: "1.3.3.6" - subsystem: + - "Fatty acid degradation" - annotation: !!omap - bigg.reaction: "ACOAO9p" - kegg.pathway: @@ -32381,6 +32426,7 @@ - gene_reaction_rule: "YGL205W" - eccodes: "1.3.3.6" - subsystem: + - "Fatty acid degradation" - annotation: !!omap - bigg.reaction: "ACOAO7p" - kegg.pathway: @@ -32405,6 +32451,7 @@ - gene_reaction_rule: "YGL205W" - eccodes: "1.3.3.6" - subsystem: + - "Fatty acid degradation" - annotation: !!omap - bigg.reaction: "ACOAO8p" - kegg.pathway: @@ -32429,6 +32476,7 @@ - gene_reaction_rule: "YGL205W" - eccodes: "1.3.3.6" - subsystem: + - "Fatty acid degradation" - annotation: !!omap - bigg.reaction: "ACOAO6p" - kegg.pathway: @@ -32453,6 +32501,7 @@ - gene_reaction_rule: "YCR048W" - eccodes: "2.3.1.26" - subsystem: + - "Steroid biosynthesis" - annotation: !!omap - kegg.pathway: "sce00100" - pubmed: "10672016" @@ -32471,6 +32520,7 @@ - gene_reaction_rule: "YCR048W or YNR019W" - eccodes: "2.3.1.26" - subsystem: + - "Steroid biosynthesis" - annotation: !!omap - kegg.pathway: "sce00100" - metanetx.reaction: "MNXR119161" @@ -32490,6 +32540,7 @@ - gene_reaction_rule: "YCR048W" - eccodes: "2.3.1.26" - subsystem: + - "Steroid biosynthesis" - annotation: !!omap - kegg.pathway: "sce00100" - pubmed: "10672016" @@ -32508,6 +32559,7 @@ - gene_reaction_rule: "YCR048W" - eccodes: "2.3.1.26" - subsystem: + - "Steroid biosynthesis" - annotation: !!omap - kegg.pathway: "sce00100" - metanetx.reaction: "MNXR119159" @@ -32527,6 +32579,7 @@ - gene_reaction_rule: "YCR048W" - eccodes: "2.3.1.26" - subsystem: + - "Steroid biosynthesis" - annotation: !!omap - kegg.pathway: "sce00100" - pubmed: "10672016" @@ -32545,6 +32598,7 @@ - gene_reaction_rule: "YCR048W" - eccodes: "2.3.1.26" - subsystem: + - "Steroid biosynthesis" - annotation: !!omap - kegg.pathway: "sce00100" - pubmed: "10672016" @@ -32563,6 +32617,7 @@ - gene_reaction_rule: "YCR048W or YNR019W" - eccodes: "2.3.1.26" - subsystem: + - "Steroid biosynthesis" - annotation: !!omap - kegg.pathway: "sce00100" - pubmed: "10672016" @@ -32581,6 +32636,7 @@ - gene_reaction_rule: "YCR048W" - eccodes: "2.3.1.26" - subsystem: + - "Steroid biosynthesis" - annotation: !!omap - kegg.pathway: "sce00100" - pubmed: "10672016" @@ -32599,6 +32655,7 @@ - gene_reaction_rule: "YCR048W" - eccodes: "2.3.1.26" - subsystem: + - "Steroid biosynthesis" - annotation: !!omap - kegg.pathway: "sce00100" - pubmed: "10672016" @@ -32617,6 +32674,7 @@ - gene_reaction_rule: "YCR048W" - eccodes: "2.3.1.26" - subsystem: + - "Steroid biosynthesis" - annotation: !!omap - kegg.pathway: "sce00100" - pubmed: "10672016" @@ -32635,6 +32693,7 @@ - gene_reaction_rule: "YJL091C" - eccodes: "2.3.-.-" - subsystem: + - "Glycosylphosphatidylinositol (gpi)-anchor biosynthesis" - annotation: !!omap - kegg.pathway: "sce00563" - pubmed: "12714589" @@ -32654,6 +32713,7 @@ - gene_reaction_rule: "YNL141W" - eccodes: "3.5.4.2" - subsystem: + - "Purine metabolism" - annotation: !!omap - bigg.reaction: "ADD" - kegg.pathway: "sce00230" @@ -32674,6 +32734,7 @@ - gene_reaction_rule: "YDR441C or YML022W" - eccodes: "2.4.2.7" - subsystem: + - "Purine metabolism" - annotation: !!omap - bigg.reaction: "ADPT" - kegg.pathway: "sce00230" @@ -32696,6 +32757,7 @@ - gene_reaction_rule: "YNL141W" - eccodes: "3.5.4.2" - subsystem: + - "Purine metabolism" - annotation: !!omap - bigg.reaction: "ADA" - kegg.pathway: "sce00230" @@ -32717,6 +32779,7 @@ - gene_reaction_rule: "YJR105W" - eccodes: "2.7.1.20" - subsystem: + - "Purine metabolism" - annotation: !!omap - bigg.reaction: "ADNK1" - kegg.pathway: "sce00230" @@ -32738,6 +32801,7 @@ - gene_reaction_rule: "YML035C" - eccodes: "3.5.4.6" - subsystem: + - "Purine metabolism" - annotation: !!omap - bigg.reaction: "AMPDA" - kegg.pathway: @@ -32761,6 +32825,7 @@ - gene_reaction_rule: "YER043C" - eccodes: "3.3.1.1" - subsystem: + - "Cysteine and methionine metabolism" - annotation: !!omap - bigg.reaction: "AHCi" - kegg.pathway: "sce00270" @@ -32782,6 +32847,7 @@ - gene_reaction_rule: "YOL052C" - eccodes: "4.1.1.50" - subsystem: + - "Arginine and proline metabolism" - annotation: !!omap - bigg.reaction: "ADMDC" - kegg.pathway: @@ -32805,6 +32871,7 @@ - gene_reaction_rule: "YNR058W" - eccodes: "2.6.1.62" - subsystem: + - "Biotin metabolism" - annotation: !!omap - bigg.reaction: "AMAOTr" - kegg.pathway: "sce00780" @@ -32824,6 +32891,7 @@ - gene_reaction_rule: "YJL005W" - eccodes: "4.6.1.1" - subsystem: + - "Purine metabolism" - annotation: !!omap - bigg.reaction: "ADNCYC" - kegg.pathway: @@ -32846,6 +32914,7 @@ - gene_reaction_rule: "YDL166C or YDR226W" - eccodes: "2.7.4.3" - subsystem: + - "Purine metabolism" - annotation: !!omap - bigg.reaction: "ADK1" - kegg.pathway: @@ -32869,6 +32938,7 @@ - gene_reaction_rule: "YER170W" - eccodes: "2.7.4.10" - subsystem: + - "Purine metabolism" - annotation: !!omap - bigg.reaction: "ADK1m" - kegg.pathway: @@ -32893,6 +32963,7 @@ - gene_reaction_rule: "YER170W" - eccodes: "2.7.4.10" - subsystem: + - "Purine metabolism" - annotation: !!omap - bigg.reaction: "ADK3m" - kegg.pathway: @@ -32915,6 +32986,7 @@ - gene_reaction_rule: "YLR359W" - eccodes: "4.3.2.2" - subsystem: + - "Purine metabolism" - annotation: !!omap - bigg.reaction: "ADSL2r" - kegg.pathway: @@ -32938,6 +33010,7 @@ - gene_reaction_rule: "YLR359W" - eccodes: "4.3.2.2" - subsystem: + - "Purine metabolism" - annotation: !!omap - bigg.reaction: "ADSL1r" - kegg.pathway: @@ -32965,6 +33038,7 @@ - gene_reaction_rule: "YNL220W" - eccodes: "6.3.4.4" - subsystem: + - "Purine metabolism" - annotation: !!omap - bigg.reaction: "ADSS" - kegg.pathway: @@ -32988,6 +33062,7 @@ - gene_reaction_rule: "YKL001C" - eccodes: "2.7.1.25" - subsystem: + - "Sulfur metabolism" - annotation: !!omap - bigg.reaction: "ADSK" - kegg.pathway: @@ -33011,6 +33086,7 @@ - gene_reaction_rule: "YGR247W" - eccodes: "3.1.4.37" - subsystem: + - "Cyclic nucleotide metabolism" - annotation: !!omap - bigg.reaction: "23CAPPD" - metanetx.reaction: "MNXR117324" @@ -33030,6 +33106,7 @@ - gene_reaction_rule: "YFL030W" - eccodes: "2.6.1.44" - subsystem: + - "Alanine, aspartate and glutamate metabolism" - annotation: !!omap - bigg.reaction: "AGTi" - kegg.pathway: @@ -33059,6 +33136,7 @@ - gene_reaction_rule: "YOR335C" - eccodes: "6.1.1.7" - subsystem: + - "tRNA metabolism" - annotation: !!omap - bigg.reaction: "ALATRS" - kegg.pathway: "sce00970" @@ -33080,6 +33158,7 @@ - gene_reaction_rule: "YGR177C or YOR377W" - eccodes: "2.3.1.84" - subsystem: + - "Complex alcohol metabolism" - annotation: !!omap - bigg.reaction: "OHACT3" - metanetx.reaction: "MNXR102165" @@ -33099,6 +33178,7 @@ - gene_reaction_rule: "YGR177C or YOR377W" - eccodes: "2.3.1.84" - subsystem: + - "Complex alcohol metabolism" - annotation: !!omap - metanetx.reaction: "MNXR117501" - pubmed: "12957907" @@ -33117,6 +33197,7 @@ - gene_reaction_rule: "YGR177C or YOR377W" - eccodes: "2.3.1.84" - subsystem: + - "Complex alcohol metabolism" - annotation: !!omap - bigg.reaction: "OHACT2" - metanetx.reaction: "MNXR102164" @@ -33136,6 +33217,7 @@ - gene_reaction_rule: "YGR177C or YOR377W" - eccodes: "2.3.1.84" - subsystem: + - "Complex alcohol metabolism" - annotation: !!omap - bigg.reaction: "OHACT4" - metanetx.reaction: "MNXR102166" @@ -33155,6 +33237,7 @@ - gene_reaction_rule: "YGR177C or YOR377W" - eccodes: "2.3.1.84" - subsystem: + - "Complex alcohol metabolism" - annotation: !!omap - bigg.reaction: "OHACT5" - metanetx.reaction: "MNXR102167" @@ -33175,6 +33258,7 @@ - gene_reaction_rule: "YMR303C" - eccodes: "1.1.1.1" - subsystem: + - "Glycolysis / gluconeogenesis" - annotation: !!omap - bigg.reaction: "ALCD2x" - kegg.pathway: @@ -33204,6 +33288,7 @@ - "1.1.1.-" - "1.1.1.21" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - bigg.reaction: "ALCD19y" - kegg.pathway: "sce00040" @@ -33226,6 +33311,7 @@ - gene_reaction_rule: "YGL256W or YMR083W" - eccodes: "1.1.1.1" - subsystem: + - "Glycolysis / gluconeogenesis" - annotation: !!omap - bigg.reaction: "ALCD2irm" - kegg.pathway: @@ -33256,6 +33342,7 @@ - "1.1.1.1" - "1.1.1.284" - subsystem: + - "Complex alcohol metabolism" - annotation: !!omap - bigg.reaction: "ALCD22xi" - kegg.pathway: @@ -33283,6 +33370,7 @@ - gene_reaction_rule: "YGL256W or YMR083W" - eccodes: "1.1.1.1" - subsystem: + - "Complex alcohol metabolism" - annotation: !!omap - bigg.reaction: "ALCD22xim" - kegg.pathway: @@ -33311,6 +33399,7 @@ - "1.1.1.-" - "1.1.1.2" - subsystem: + - "Complex alcohol metabolism" - annotation: !!omap - bigg.reaction: "ALCD22yi" - kegg.pathway: @@ -33342,6 +33431,7 @@ - "1.1.1.1" - "1.1.1.284" - subsystem: + - "Phenylalanine metabolism" - annotation: !!omap - bigg.reaction: "ALCD25xi" - kegg.pathway: @@ -33370,6 +33460,7 @@ - gene_reaction_rule: "YGL256W or YMR083W" - eccodes: "1.1.1.1" - subsystem: + - "Phenylalanine metabolism" - annotation: !!omap - bigg.reaction: "ALCD25xim" - kegg.pathway: @@ -33397,6 +33488,7 @@ - gene_reaction_rule: "YCR105W or YMR318C" - eccodes: "1.1.1.2" - subsystem: + - "Phenylalanine metabolism" - annotation: !!omap - bigg.reaction: "ALCD25yi" - kegg.pathway: @@ -33426,6 +33518,7 @@ - gene_reaction_rule: "YMR110C or YMR169C or YMR170C" - eccodes: "1.2.1.3" - subsystem: + - "Beta-alanine metabolism" - annotation: !!omap - bigg.reaction: "ALDD22x" - kegg.pathway: @@ -33455,6 +33548,7 @@ - gene_reaction_rule: "YPL061W" - eccodes: "1.2.1.4" - subsystem: + - "Glycolysis / gluconeogenesis" - annotation: !!omap - bigg.reaction: "ALDD2y" - kegg.pathway: @@ -33490,6 +33584,7 @@ - gene_reaction_rule: "YOR374W" - eccodes: "1.2.1.5" - subsystem: + - "Glycolysis / gluconeogenesis" - annotation: !!omap - bigg.reaction: "ALDD2xm" - kegg.pathway: @@ -33525,6 +33620,7 @@ - gene_reaction_rule: "YER073W or YOR374W" - eccodes: "1.2.1.5" - subsystem: + - "Pyruvate metabolism" - annotation: !!omap - bigg.reaction: "ALDD2ym" - kegg.pathway: @@ -33560,6 +33656,7 @@ - gene_reaction_rule: "YOR374W" - eccodes: "1.2.1.5" - subsystem: + - "Tryptophan metabolism" - annotation: !!omap - bigg.reaction: "ALDD20xm" - kegg.pathway: @@ -33594,6 +33691,7 @@ - gene_reaction_rule: "YPL061W" - eccodes: "1.2.1.4" - subsystem: + - "Tryptophan metabolism" - annotation: !!omap - bigg.reaction: "ALDD20y" - kegg.pathway: @@ -33627,6 +33725,7 @@ - gene_reaction_rule: "YER073W or YOR374W" - eccodes: "1.2.1.5" - subsystem: + - "Tryptophan metabolism" - annotation: !!omap - bigg.reaction: "ALDD20ym" - kegg.pathway: @@ -33663,6 +33762,7 @@ - "1.1.1.1" - "1.1.1.284" - subsystem: + - "Complex alcohol metabolism" - annotation: !!omap - bigg.reaction: "ALCD24xi" - kegg.pathway: @@ -33691,6 +33791,7 @@ - gene_reaction_rule: "YGL256W or YMR083W" - eccodes: "1.1.1.1" - subsystem: + - "Complex alcohol metabolism" - annotation: !!omap - bigg.reaction: "ALCD24xim" - kegg.pathway: @@ -33718,6 +33819,7 @@ - gene_reaction_rule: "YCR105W or YMR318C" - eccodes: "1.1.1.2" - subsystem: + - "Complex alcohol metabolism" - annotation: !!omap - bigg.reaction: "ALCD24yi" - kegg.pathway: @@ -33750,6 +33852,7 @@ - "1.1.1.1" - "1.1.1.284" - subsystem: + - "Complex alcohol metabolism" - annotation: !!omap - bigg.reaction: "ALCD23xi" - kegg.pathway: @@ -33777,6 +33880,7 @@ - gene_reaction_rule: "YGL256W or YMR083W" - eccodes: "1.1.1.1" - subsystem: + - "Complex alcohol metabolism" - annotation: !!omap - bigg.reaction: "ALCD23xim" - kegg.pathway: @@ -33803,6 +33907,7 @@ - gene_reaction_rule: "YCR105W or YMR318C" - eccodes: "1.1.1.2" - subsystem: + - "Complex alcohol metabolism" - annotation: !!omap - bigg.reaction: "ALCD23yi" - kegg.pathway: @@ -33832,6 +33937,7 @@ - gene_reaction_rule: "YMR169C or YMR170C" - eccodes: "1.2.1.3" - subsystem: + - "Phenylalanine metabolism" - annotation: !!omap - bigg.reaction: "ALDD19xr" - kegg.pathway: @@ -33863,6 +33969,7 @@ - "1.1.1.1" - "1.1.1.284" - subsystem: + - "Tyrosine metabolism" - annotation: !!omap - bigg.reaction: "ALCD26xi" - kegg.pathway: @@ -33891,6 +33998,7 @@ - gene_reaction_rule: "YGL256W or YMR083W" - eccodes: "1.1.1.1" - subsystem: + - "Tyrosine metabolism" - annotation: !!omap - bigg.reaction: "ALCD26xim" - kegg.pathway: @@ -33921,6 +34029,7 @@ - "3.1.3.54" - "3.1.7.6" - subsystem: + - "Folate biosynthesis" - annotation: !!omap - bigg.reaction: "AKP1" - kegg.pathway: @@ -33943,6 +34052,7 @@ - gene_reaction_rule: "YIR029W" - eccodes: "3.5.3.4" - subsystem: + - "Purine metabolism" - annotation: !!omap - bigg.reaction: "ALLTAHr" - kegg.pathway: "sce00230" @@ -33964,6 +34074,7 @@ - gene_reaction_rule: "YIR027C" - eccodes: "3.5.2.5" - subsystem: + - "Purine metabolism" - annotation: !!omap - bigg.reaction: "ALLTN" - kegg.pathway: "sce00230" @@ -33988,6 +34099,7 @@ - "3.5.1.54" - "6.3.4.6" - subsystem: + - "Arginine biosynthesis" - annotation: !!omap - bigg.reaction: "ALPHNH" - kegg.pathway: @@ -34011,6 +34123,7 @@ - gene_reaction_rule: "YBR199W or YBR205W or YDR483W or YJL139C or YKR061W or YNL029C or YOR099W or YPL053C" - eccodes: "2.4.1.-" - subsystem: + - "N-glycan biosynthesis" - annotation: !!omap - kegg.pathway: - "sce00513" @@ -34036,6 +34149,7 @@ - gene_reaction_rule: "YPR026W or YBR001C" - eccodes: "3.2.1.28" - subsystem: + - "Starch and sucrose metabolism" - annotation: !!omap - bigg.reaction: "TREHv" - kegg.pathway: "sce00500" @@ -34055,6 +34169,7 @@ - gene_reaction_rule: "YDR001C" - eccodes: "3.2.1.28" - subsystem: + - "Starch and sucrose metabolism" - annotation: !!omap - bigg.reaction: "TREH" - kegg.pathway: "sce00500" @@ -34079,6 +34194,7 @@ - "2.4.1.15" - "3.1.3.12" - subsystem: + - "Starch and sucrose metabolism" - annotation: !!omap - bigg.reaction: "TRE6PS" - kegg.pathway: "sce00500" @@ -34101,6 +34217,7 @@ - "3.2.1.10" - "3.2.1.20" - subsystem: + - "Starch and sucrose metabolism" - annotation: !!omap - bigg.reaction: "MALT" - kegg.pathway: @@ -34123,6 +34240,7 @@ - gene_reaction_rule: "YDR242W or YMR293C" - eccodes: "6.3.5.7" - subsystem: + - "Arginine and proline metabolism" - annotation: !!omap - bigg.reaction: "AMID" - kegg.pathway: "sce00970" @@ -34143,6 +34261,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Glycine, serine and threonine metabolism" - annotation: !!omap - bigg.reaction: "AACTOOR" - kegg.reaction: "R02529" @@ -34165,6 +34284,7 @@ - gene_reaction_rule: "YOR374W" - eccodes: "1.2.1.5" - subsystem: + - "Arginine and proline metabolism" - annotation: !!omap - bigg.reaction: "ABUTDm" - kegg.pathway: @@ -34197,6 +34317,7 @@ - gene_reaction_rule: "YDR354W" - eccodes: "2.4.2.18" - subsystem: + - "Phenylalanine, tyrosine and tryptophan biosynthesis" - annotation: !!omap - bigg.reaction: "ANPRT" - kegg.pathway: @@ -34223,6 +34344,7 @@ - gene_reaction_rule: "YER090W and YKL211C" - eccodes: "4.1.3.27" - subsystem: + - "Phenylalanine, tyrosine and tryptophan biosynthesis" - annotation: !!omap - bigg.reaction: "ANS" - kegg.pathway: @@ -34248,6 +34370,7 @@ - gene_reaction_rule: "YDR305C" - eccodes: "3.6.1.29" - subsystem: + - "Purine metabolism" - annotation: !!omap - bigg.reaction: "AP4AH" - kegg.pathway: "sce00230" @@ -34271,6 +34394,7 @@ - "1.1.1.-" - "1.1.1.21" - subsystem: + - "Pentose and glucuronate interconversions" - annotation: !!omap - bigg.reaction: "ARABR" - kegg.pathway: "sce00040" @@ -34291,6 +34415,7 @@ - gene_reaction_rule: "YPL111W" - eccodes: "3.5.3.1" - subsystem: + - "Arginine biosynthesis" - annotation: !!omap - bigg.reaction: "ARGN" - kegg.pathway: @@ -34315,6 +34440,7 @@ - gene_reaction_rule: "YHR018C" - eccodes: "4.3.2.1" - subsystem: + - "Arginine biosynthesis" - annotation: !!omap - bigg.reaction: "ARGSL" - kegg.pathway: @@ -34343,6 +34469,7 @@ - gene_reaction_rule: "YOL058W" - eccodes: "6.3.4.5" - subsystem: + - "Arginine biosynthesis" - annotation: !!omap - bigg.reaction: "ARGSS" - kegg.pathway: @@ -34371,6 +34498,7 @@ - gene_reaction_rule: "YDR341C" - eccodes: "6.1.1.19" - subsystem: + - "tRNA metabolism" - annotation: !!omap - bigg.reaction: "ARGTRS" - kegg.pathway: "sce00970" @@ -34393,6 +34521,7 @@ - gene_reaction_rule: "YHR091C" - eccodes: "6.1.1.19" - subsystem: + - "tRNA metabolism" - annotation: !!omap - bigg.reaction: "ARGTRSm" - kegg.pathway: "sce00970" @@ -34418,6 +34547,7 @@ - gene_reaction_rule: "YGR124W or YPR145W" - eccodes: "6.3.5.4" - subsystem: + - "Alanine, aspartate and glutamate metabolism" - annotation: !!omap - bigg.reaction: "ASNS1" - kegg.pathway: @@ -34443,6 +34573,7 @@ - gene_reaction_rule: "YHR019C" - eccodes: "6.1.1.22" - subsystem: + - "tRNA metabolism" - annotation: !!omap - bigg.reaction: "ASNTRS" - kegg.pathway: "sce00970" @@ -34466,6 +34597,7 @@ - gene_reaction_rule: "YCR024C" - eccodes: "6.1.1.22" - subsystem: + - "tRNA metabolism" - annotation: !!omap - bigg.reaction: "ASNTRSm" - kegg.pathway: "sce00970" @@ -34490,6 +34622,7 @@ - "2.1.3.2" - "6.3.5.5" - subsystem: + - "Pyrimidine metabolism" - annotation: !!omap - bigg.reaction: "ASPCT" - kegg.pathway: @@ -34512,6 +34645,7 @@ - gene_reaction_rule: "YER052C" - eccodes: "2.7.2.4" - subsystem: + - "Glycine, serine and threonine metabolism" - annotation: !!omap - bigg.reaction: "ASPK" - kegg.pathway: @@ -34541,6 +34675,7 @@ - gene_reaction_rule: "YLR027C" - eccodes: "2.6.1.1" - subsystem: + - "Alanine, aspartate and glutamate metabolism" - annotation: !!omap - bigg.reaction: "ASPTA" - kegg.pathway: @@ -34574,6 +34709,7 @@ - gene_reaction_rule: "YKL106W" - eccodes: "2.6.1.1" - subsystem: + - "Alanine, aspartate and glutamate metabolism" - annotation: !!omap - bigg.reaction: "ASPTAm" - kegg.pathway: @@ -34607,6 +34743,7 @@ - gene_reaction_rule: "YLR027C" - eccodes: "2.6.1.1" - subsystem: + - "Alanine, aspartate and glutamate metabolism" - annotation: !!omap - bigg.reaction: "ASPTAp" - kegg.pathway: @@ -34642,6 +34779,7 @@ - gene_reaction_rule: "YDR158W" - eccodes: "1.2.1.11" - subsystem: + - "Glycine, serine and threonine metabolism" - annotation: !!omap - bigg.reaction: "ASAD" - kegg.pathway: @@ -34673,6 +34811,7 @@ - gene_reaction_rule: "YLL018C" - eccodes: "6.1.1.12" - subsystem: + - "tRNA metabolism" - annotation: !!omap - bigg.reaction: "ASPTRS" - kegg.pathway: "sce00970" @@ -34696,6 +34835,7 @@ - gene_reaction_rule: "YPL104W" - eccodes: "6.1.1.12" - subsystem: + - "tRNA metabolism" - annotation: !!omap - bigg.reaction: "ASPTRSm" - kegg.pathway: "sce00970" @@ -34720,6 +34860,7 @@ - "2.7.7.5" - "2.7.7.53" - subsystem: + - "Purine metabolism" - annotation: !!omap - bigg.reaction: "ATPATF1" - kegg.pathway: "sce00230" @@ -34743,6 +34884,7 @@ - "2.7.7.5" - "2.7.7.53" - subsystem: + - "Purine metabolism" - annotation: !!omap - bigg.reaction: "ATPATF2" - kegg.pathway: @@ -34767,6 +34909,7 @@ - "2.7.7.5" - "2.7.7.53" - subsystem: + - "Purine metabolism" - annotation: !!omap - bigg.reaction: "ATPATF3" - kegg.pathway: @@ -34788,6 +34931,7 @@ - gene_reaction_rule: "YER055C" - eccodes: "2.4.2.17" - subsystem: + - "Histidine metabolism" - annotation: !!omap - bigg.reaction: "ATPPRT" - kegg.pathway: @@ -34813,6 +34957,7 @@ - gene_reaction_rule: "(Q0080 and Q0085 and Q0130 and YBL099W and YBR039W and YDL004W and YDR298C and YDR322C-A and YDR377W and YJR121W and YKL016C and YLR295C and YML081C-A and YPL078C and YPL271W) or (Q0080 and Q0085 and Q0130 and YBL099W and YBR039W and YDL004W and YDR298C and YDR377W and YJR121W and YKL016C and YLR295C and YML081C-A and YPL078C and YPL271W and YPR020W) or (Q0080 and Q0085 and Q0130 and YBL099W and YBR039W and YDL004W and YDR298C and YDR322C-A and YDR377W and YJR121W and YKL016C and YLR295C and YML081C-A and YPL078C and YPL271W and YJL180C and YLR393W and YNL315C and YOL077W-A and YCL005W-A)" - eccodes: "3.6.3.14" - subsystem: + - "Oxidative phosphorylation" - annotation: !!omap - bigg.reaction: "ATPS3m" - kegg.pathway: "sce00190" @@ -34838,6 +34983,7 @@ - "3.6.1.5" - "3.6.3.6" - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "ATPS" - kegg.pathway: @@ -34863,6 +35009,7 @@ - gene_reaction_rule: "YBR110W" - eccodes: "2.4.1.142" - subsystem: + - "N-glycan biosynthesis" - annotation: !!omap - kegg.pathway: - "sce00510" @@ -34885,6 +35032,7 @@ - gene_reaction_rule: "YGR286C" - eccodes: "2.8.1.6" - subsystem: + - "Biotin metabolism" - annotation: !!omap - kegg.pathway: "sce00780" - sbo: "SBO:0000176" @@ -34908,6 +35056,7 @@ - "6.3.4.15" - "6.3.4.9" - subsystem: + - "Biotin metabolism" - annotation: !!omap - bigg.reaction: "BACCL" - kegg.pathway: "sce00780" @@ -34930,6 +35079,7 @@ - gene_reaction_rule: "YNL280C" - eccodes: "1.3.1.70" - subsystem: + - "Steroid biosynthesis" - annotation: !!omap - bigg.reaction: "C14STR" - kegg.pathway: @@ -34956,6 +35106,7 @@ - gene_reaction_rule: "YMR015C" - eccodes: "1.14.19.41" - subsystem: + - "Steroid biosynthesis" - annotation: !!omap - bigg.reaction: "C22STDS" - kegg.pathway: @@ -34979,6 +35130,7 @@ - gene_reaction_rule: "YGL001C" - eccodes: "1.1.1.170" - subsystem: + - "Steroid biosynthesis" - annotation: !!omap - kegg.pathway: - "sce00100" @@ -35000,6 +35152,7 @@ - gene_reaction_rule: "YGL001C" - eccodes: "1.1.1.170" - subsystem: + - "Steroid biosynthesis" - annotation: !!omap - kegg.pathway: - "sce00100" @@ -35021,6 +35174,7 @@ - gene_reaction_rule: "YLR100W" - eccodes: "1.1.1.270" - subsystem: + - "Steroid biosynthesis" - annotation: !!omap - kegg.pathway: - "sce00100" @@ -35043,6 +35197,7 @@ - gene_reaction_rule: "YLR100W" - eccodes: "1.1.1.270" - subsystem: + - "Steroid biosynthesis" - annotation: !!omap - bigg.reaction: "HMR_1509" - kegg.pathway: @@ -35067,6 +35222,7 @@ - gene_reaction_rule: "YGR060W" - eccodes: "1.14.13.72" - subsystem: + - "Steroid biosynthesis" - annotation: !!omap - kegg.pathway: - "sce00100" @@ -35090,6 +35246,7 @@ - gene_reaction_rule: "YGR060W" - eccodes: "1.14.13.72" - subsystem: + - "Steroid biosynthesis" - annotation: !!omap - bigg.reaction: "HMR_1503" - kegg.pathway: @@ -35113,6 +35270,7 @@ - gene_reaction_rule: "YGR060W" - eccodes: "1.14.13.72" - subsystem: + - "Steroid biosynthesis" - annotation: !!omap - kegg.pathway: - "sce00100" @@ -35136,6 +35294,7 @@ - gene_reaction_rule: "YGR060W" - eccodes: "1.14.13.72" - subsystem: + - "Steroid biosynthesis" - annotation: !!omap - kegg.pathway: - "sce00100" @@ -35160,6 +35319,7 @@ - gene_reaction_rule: "YLR056W" - eccodes: "1.14.19.20" - subsystem: + - "Steroid biosynthesis" - annotation: !!omap - bigg.reaction: "C5STDS" - kegg.pathway: @@ -35180,6 +35340,7 @@ - gene_reaction_rule: "YMR202W" - eccodes: "5.-.-.-" - subsystem: + - "Steroid biosynthesis" - annotation: !!omap - bigg.reaction: "C8STI" - kegg.pathway: @@ -35203,6 +35364,7 @@ - gene_reaction_rule: "YGL012W" - eccodes: "1.3.1.71" - subsystem: + - "Steroid biosynthesis" - annotation: !!omap - bigg.reaction: "C24STRer" - kegg.pathway: @@ -35225,6 +35387,7 @@ - gene_reaction_rule: "YDL090C and YKL019W" - eccodes: "2.5.1.58" - subsystem: + - "Terpenoid backbone biosynthesis" - annotation: !!omap - kegg.pathway: - "sce00900" @@ -35254,6 +35417,7 @@ - "2.1.3.2" - "6.3.5.5" - subsystem: + - "Pyrimidine metabolism" - annotation: !!omap - bigg.reaction: "CBPS" - kegg.pathway: @@ -35276,6 +35440,7 @@ - gene_reaction_rule: "YAR035W or YER024W" - eccodes: "2.3.1.7" - subsystem: + - "Carnitine metabolism" - annotation: !!omap - bigg.reaction: "CSNATr" - kegg.pathway: "sce04146" @@ -35297,6 +35462,7 @@ - gene_reaction_rule: "YML042W" - eccodes: "2.3.1.7" - subsystem: + - "Carnitine metabolism" - annotation: !!omap - bigg.reaction: "CSNATp" - kegg.pathway: "sce04146" @@ -35317,6 +35483,7 @@ - gene_reaction_rule: "YML042W" - eccodes: "2.3.1.7" - subsystem: + - "Carnitine metabolism" - annotation: !!omap - bigg.reaction: "CSNATm" - kegg.pathway: "sce04146" @@ -35336,6 +35503,7 @@ - gene_reaction_rule: "YGR088W" - eccodes: "1.11.1.6" - subsystem: + - "Glyoxylate and dicarboxylate metabolism" - annotation: !!omap - bigg.reaction: "CAT" - kegg.pathway: @@ -35364,6 +35532,7 @@ - gene_reaction_rule: "YDR256C" - eccodes: "1.11.1.6" - subsystem: + - "Glyoxylate and dicarboxylate metabolism" - annotation: !!omap - bigg.reaction: "CATp" - kegg.pathway: @@ -35396,6 +35565,7 @@ - gene_reaction_rule: "YDR297W" - eccodes: "1.-.-.-" - subsystem: + - "Sphingolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00600" - metanetx.reaction: "MNXR126673" @@ -35420,6 +35590,7 @@ - gene_reaction_rule: "YMR272C" - eccodes: "1.-.-.-" - subsystem: + - "Sphingolipid metabolism" - annotation: !!omap - metanetx.reaction: "MNXR126668" - pubmed: @@ -35443,6 +35614,7 @@ - gene_reaction_rule: "YDR297W" - eccodes: "1.-.-.-" - subsystem: + - "Sphingolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00600" - metanetx.reaction: "MNXR126661" @@ -35467,6 +35639,7 @@ - gene_reaction_rule: "YMR272C" - eccodes: "1.-.-.-" - subsystem: + - "Sphingolipid metabolism" - annotation: !!omap - metanetx.reaction: "MNXR126662" - pubmed: @@ -35485,9 +35658,10 @@ - s_1480: -1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "(YHL003C and YMR298W) or (YKL008C and YMR298W)" + - gene_reaction_rule: "YKL008C and YHL003C and YMR298W" - eccodes: "2.3.1.24" - subsystem: + - "Sphingolipid metabolism" - annotation: !!omap - bigg.reaction: "CERS124er" - kegg.pathway: "sce00600" @@ -35509,9 +35683,10 @@ - s_1445: -1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "(YHL003C and YMR298W) or (YKL008C and YMR298W)" + - gene_reaction_rule: "YKL008C and YHL003C and YMR298W" - eccodes: "2.3.1.24" - subsystem: + - "Sphingolipid metabolism" - annotation: !!omap - bigg.reaction: "CERS126er" - kegg.pathway: "sce00600" @@ -35534,9 +35709,10 @@ - s_1480: -1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "(YHL003C and YMR298W) or (YKL008C and YMR298W)" + - gene_reaction_rule: "YKL008C and YHL003C and YMR298W" - eccodes: "2.3.1.24" - subsystem: + - "Sphingolipid metabolism" - annotation: !!omap - bigg.reaction: "CERS224er" - kegg.pathway: "sce00600" @@ -35558,9 +35734,10 @@ - s_1366: -1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "(YHL003C and YMR298W) or (YKL008C and YMR298W)" + - gene_reaction_rule: "YKL008C and YHL003C and YMR298W" - eccodes: "2.3.1.24" - subsystem: + - "Sphingolipid metabolism" - annotation: !!omap - bigg.reaction: "CERS226er" - kegg.pathway: "sce00600" @@ -35588,6 +35765,7 @@ - gene_reaction_rule: "YMR272C" - eccodes: "1.-.-.-" - subsystem: + - "Sphingolipid metabolism" - annotation: !!omap - metanetx.reaction: "MNXR126670" - pubmed: @@ -35611,6 +35789,7 @@ - gene_reaction_rule: "YMR272C" - eccodes: "1.-.-.-" - subsystem: + - "Sphingolipid metabolism" - annotation: !!omap - metanetx.reaction: "MNXR126669" - pubmed: @@ -35634,6 +35813,7 @@ - gene_reaction_rule: "YMR272C" - eccodes: "1.-.-.-" - subsystem: + - "Sphingolipid metabolism" - annotation: !!omap - metanetx.reaction: "MNXR126672" - pubmed: @@ -35657,6 +35837,7 @@ - gene_reaction_rule: "YMR272C" - eccodes: "1.-.-.-" - subsystem: + - "Sphingolipid metabolism" - annotation: !!omap - metanetx.reaction: "MNXR126671" - pubmed: @@ -35678,6 +35859,7 @@ - gene_reaction_rule: "YLR307W or YLR308W" - eccodes: "3.5.1.41" - subsystem: + - "Amino sugar and nucleotide sugar metabolism" - annotation: !!omap - kegg.pathway: "sce00520" - kegg.reaction: "R02333" @@ -35697,6 +35879,7 @@ - gene_reaction_rule: "YBR023C or YBR038W or YNL192W" - eccodes: "2.4.1.16" - subsystem: + - "Amino sugar and nucleotide sugar metabolism" - annotation: !!omap - kegg.pathway: "sce00520" - kegg.reaction: "R02335" @@ -35718,6 +35901,7 @@ - gene_reaction_rule: "YLR133W" - eccodes: "2.7.1.32" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - bigg.reaction: "CHOLK" - kegg.pathway: "sce00564" @@ -35740,6 +35924,7 @@ - gene_reaction_rule: "YGR202C" - eccodes: "2.7.7.15" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - bigg.reaction: "CHLPCTD" - kegg.pathway: @@ -35760,6 +35945,7 @@ - gene_reaction_rule: "YPR060C" - eccodes: "5.4.99.5" - subsystem: + - "Phenylalanine, tyrosine and tryptophan biosynthesis" - annotation: !!omap - bigg.reaction: "CHORM" - kegg.pathway: @@ -35784,6 +35970,7 @@ - gene_reaction_rule: "YGL148W" - eccodes: "4.2.3.5" - subsystem: + - "Phenylalanine, tyrosine and tryptophan biosynthesis" - annotation: !!omap - bigg.reaction: "CHORS" - kegg.pathway: @@ -35808,6 +35995,7 @@ - gene_reaction_rule: "YLR304C" - eccodes: "4.2.1.3" - subsystem: + - "Citrate cycle (TCA cycle)" - annotation: !!omap - bigg.reaction: "ACN_b_m" - kegg.pathway: @@ -35836,6 +36024,7 @@ - gene_reaction_rule: "YBR002C or YMR101C" - eccodes: "2.5.1.87" - subsystem: + - "Terpenoid backbone biosynthesis" - annotation: !!omap - kegg.pathway: - "sce00900" @@ -35858,6 +36047,7 @@ - gene_reaction_rule: "YBR002C or YMR101C" - eccodes: "2.5.1.87" - subsystem: + - "Terpenoid backbone biosynthesis" - annotation: !!omap - kegg.pathway: - "sce00900" @@ -35880,6 +36070,7 @@ - gene_reaction_rule: "YBR002C or YMR101C" - eccodes: "2.5.1.87" - subsystem: + - "Terpenoid backbone biosynthesis" - annotation: !!omap - kegg.pathway: - "sce00900" @@ -35902,6 +36093,7 @@ - gene_reaction_rule: "YBR002C or YMR101C" - eccodes: "2.5.1.87" - subsystem: + - "Terpenoid backbone biosynthesis" - annotation: !!omap - kegg.pathway: - "sce00900" @@ -35924,6 +36116,7 @@ - gene_reaction_rule: "YBR002C or YMR101C" - eccodes: "2.5.1.87" - subsystem: + - "Terpenoid backbone biosynthesis" - annotation: !!omap - kegg.pathway: - "sce00900" @@ -35946,6 +36139,7 @@ - gene_reaction_rule: "YBR002C or YMR101C" - eccodes: "2.5.1.87" - subsystem: + - "Terpenoid backbone biosynthesis" - annotation: !!omap - kegg.pathway: - "sce00900" @@ -35968,6 +36162,7 @@ - gene_reaction_rule: "YBR002C or YMR101C" - eccodes: "2.5.1.87" - subsystem: + - "Terpenoid backbone biosynthesis" - annotation: !!omap - kegg.pathway: - "sce00900" @@ -35990,6 +36185,7 @@ - gene_reaction_rule: "YBR002C or YMR101C" - eccodes: "2.5.1.87" - subsystem: + - "Terpenoid backbone biosynthesis" - annotation: !!omap - kegg.pathway: - "sce00900" @@ -36011,6 +36207,7 @@ - gene_reaction_rule: "YBR002C or YMR101C" - eccodes: "2.5.1.87" - subsystem: + - "Terpenoid backbone biosynthesis" - annotation: !!omap - kegg.pathway: - "sce00900" @@ -36031,6 +36228,7 @@ - gene_reaction_rule: "YBR002C or YMR101C" - eccodes: "2.5.1.87" - subsystem: + - "Terpenoid backbone biosynthesis" - annotation: !!omap - kegg.pathway: - "sce00900" @@ -36051,6 +36249,7 @@ - gene_reaction_rule: "YBR002C or YMR101C" - eccodes: "2.5.1.87" - subsystem: + - "Terpenoid backbone biosynthesis" - annotation: !!omap - kegg.pathway: - "sce00900" @@ -36071,6 +36270,7 @@ - gene_reaction_rule: "YBR002C or YMR101C" - eccodes: "2.5.1.87" - subsystem: + - "Terpenoid backbone biosynthesis" - annotation: !!omap - kegg.pathway: - "sce00900" @@ -36091,6 +36291,7 @@ - gene_reaction_rule: "YBR002C or YMR101C" - eccodes: "2.5.1.87" - subsystem: + - "Terpenoid backbone biosynthesis" - annotation: !!omap - kegg.pathway: - "sce00900" @@ -36111,6 +36312,7 @@ - gene_reaction_rule: "YBR002C or YMR101C" - eccodes: "2.5.1.87" - subsystem: + - "Terpenoid backbone biosynthesis" - annotation: !!omap - kegg.pathway: - "sce00900" @@ -36131,6 +36333,7 @@ - gene_reaction_rule: "YBR002C or YMR101C" - eccodes: "2.5.1.87" - subsystem: + - "Terpenoid backbone biosynthesis" - annotation: !!omap - kegg.pathway: - "sce00900" @@ -36151,6 +36354,7 @@ - gene_reaction_rule: "YBR002C or YMR101C" - eccodes: "2.5.1.87" - subsystem: + - "Terpenoid backbone biosynthesis" - annotation: !!omap - kegg.pathway: - "sce00900" @@ -36171,6 +36375,7 @@ - gene_reaction_rule: "YBR002C or YMR101C" - eccodes: "2.5.1.87" - subsystem: + - "Terpenoid backbone biosynthesis" - annotation: !!omap - kegg.pathway: - "sce00900" @@ -36191,6 +36396,7 @@ - gene_reaction_rule: "YBR002C or YMR101C" - eccodes: "2.5.1.87" - subsystem: + - "Terpenoid backbone biosynthesis" - annotation: !!omap - kegg.pathway: - "sce00900" @@ -36211,6 +36417,7 @@ - gene_reaction_rule: "YBR002C or YMR101C" - eccodes: "2.5.1.87" - subsystem: + - "Terpenoid backbone biosynthesis" - annotation: !!omap - kegg.pathway: - "sce00900" @@ -36233,6 +36440,7 @@ - gene_reaction_rule: "YNR001C or YPR001W" - eccodes: "2.3.3.1" - subsystem: + - "Citrate cycle (TCA cycle)" - annotation: !!omap - bigg.reaction: "CSm" - kegg.pathway: @@ -36263,6 +36471,7 @@ - gene_reaction_rule: "YCR005C" - eccodes: "2.3.3.16" - subsystem: + - "Citrate cycle (TCA cycle)" - annotation: !!omap - bigg.reaction: "CSp" - kegg.pathway: @@ -36290,6 +36499,7 @@ - gene_reaction_rule: "YLR304C" - eccodes: "4.2.1.3" - subsystem: + - "Citrate cycle (TCA cycle)" - annotation: !!omap - bigg.reaction: "ACN_a_m" - kegg.pathway: @@ -36317,6 +36527,7 @@ - gene_reaction_rule: "YLR304C" - eccodes: "4.2.1.3" - subsystem: + - "Citrate cycle (TCA cycle)" - annotation: !!omap - bigg.reaction: "ACONTa" - kegg.pathway: @@ -36347,6 +36558,7 @@ - gene_reaction_rule: "YDR044W" - eccodes: "1.3.3.3" - subsystem: + - "Porphyrin and chlorophyll metabolism" - annotation: !!omap - bigg.reaction: "CPPPGO" - kegg.pathway: @@ -36374,6 +36586,7 @@ - gene_reaction_rule: "YBL039C or YJR103W" - eccodes: "6.3.4.2" - subsystem: + - "Pyrimidine metabolism" - annotation: !!omap - bigg.reaction: "CTPS2" - kegg.pathway: "sce00240" @@ -36397,6 +36610,7 @@ - gene_reaction_rule: "YBL039C or YJR103W" - eccodes: "6.3.4.2" - subsystem: + - "Pyrimidine metabolism" - annotation: !!omap - bigg.reaction: "CTPS1" - kegg.pathway: "sce00240" @@ -36418,6 +36632,7 @@ - gene_reaction_rule: "YFR055W or YGL184C" - eccodes: "4.4.1.8" - subsystem: + - "Cysteine and methionine metabolism" - annotation: !!omap - bigg.reaction: "CYSTL" - kegg.pathway: @@ -36443,6 +36658,7 @@ - gene_reaction_rule: "YGR155W" - eccodes: "4.2.1.22" - subsystem: + - "Glycine, serine and threonine metabolism" - annotation: !!omap - bigg.reaction: "CYSTS" - kegg.pathway: @@ -36469,6 +36685,7 @@ - gene_reaction_rule: "YAL012W" - eccodes: "4.4.1.1" - subsystem: + - "Cysteine and methionine metabolism" - annotation: !!omap - bigg.reaction: "CYSTGL" - kegg.pathway: @@ -36496,6 +36713,7 @@ - gene_reaction_rule: "YJR130C" - eccodes: "2.5.1.48" - subsystem: + - "Cysteine and methionine metabolism" - annotation: !!omap - bigg.reaction: "METB1" - kegg.pathway: @@ -36525,6 +36743,7 @@ - "2.5.1.47" - "2.5.1.49" - subsystem: + - "Cysteine and methionine metabolism" - annotation: !!omap - bigg.reaction: "CYSS" - kegg.pathway: @@ -36556,6 +36775,7 @@ - gene_reaction_rule: "YNL247W" - eccodes: "6.1.1.16" - subsystem: + - "tRNA metabolism" - annotation: !!omap - bigg.reaction: "CYSTRS" - kegg.pathway: "sce00970" @@ -36578,6 +36798,7 @@ - gene_reaction_rule: "YLR245C" - eccodes: "3.5.4.5" - subsystem: + - "Pyrimidine metabolism" - annotation: !!omap - bigg.reaction: "CYTD" - kegg.pathway: "sce00240" @@ -36599,6 +36820,7 @@ - gene_reaction_rule: "YNR012W" - eccodes: "2.7.1.48" - subsystem: + - "Pyrimidine metabolism" - annotation: !!omap - bigg.reaction: "CYTDK2" - kegg.pathway: "sce00240" @@ -36625,6 +36847,7 @@ - "1.14.13.70" - "1.6.2.4" - subsystem: + - "Steroid biosynthesis" - annotation: !!omap - bigg.reaction: "LNS14DM" - kegg.pathway: @@ -36650,6 +36873,7 @@ - gene_reaction_rule: "YPR062W" - eccodes: "3.5.4.1" - subsystem: + - "Pyrimidine metabolism" - annotation: !!omap - bigg.reaction: "CSND" - kegg.pathway: @@ -36673,6 +36897,7 @@ - gene_reaction_rule: "YML086C" - eccodes: "1.1.3.37" - subsystem: + - "Alternate carbon metabolism" - annotation: !!omap - kegg.reaction: "R02715" - metanetx.reaction: "MNXR107687" @@ -36693,6 +36918,7 @@ - gene_reaction_rule: "YMR041C" - eccodes: "1.1.1.116" - subsystem: + - "Alternate carbon metabolism" - annotation: !!omap - bigg.reaction: "ARAB1D1" - kegg.reaction: "R01574" @@ -36714,6 +36940,7 @@ - gene_reaction_rule: "YBR149W" - eccodes: "1.1.1.117" - subsystem: + - "Alternate carbon metabolism" - annotation: !!omap - bigg.reaction: "ARAB1D2" - kegg.reaction: "R01575" @@ -36732,6 +36959,7 @@ - gene_reaction_rule: "YKL060C" - eccodes: "4.1.2.13" - subsystem: + - "Glycolysis / gluconeogenesis" - annotation: !!omap - bigg.reaction: "FBA2" - kegg.pathway: @@ -36760,6 +36988,7 @@ - gene_reaction_rule: "YDL246C or YJR159W" - eccodes: "1.1.1.14" - subsystem: + - "Fructose and mannose metabolism" - annotation: !!omap - bigg.reaction: "SBTD_D2" - kegg.pathway: @@ -36783,6 +37012,7 @@ - gene_reaction_rule: "YHR144C" - eccodes: "3.5.4.12" - subsystem: + - "Pyrimidine metabolism" - annotation: !!omap - bigg.reaction: "DCMPDA" - kegg.pathway: "sce00240" @@ -36804,6 +37034,7 @@ - gene_reaction_rule: "YHR144C" - eccodes: "3.5.4.12" - subsystem: + - "Pyrimidine metabolism" - annotation: !!omap - bigg.reaction: "DCTPD" - kegg.pathway: "sce00240" @@ -36825,6 +37056,7 @@ - gene_reaction_rule: "YNL141W" - eccodes: "3.5.4.2" - subsystem: + - "Purine metabolism" - annotation: !!omap - bigg.reaction: "DADA" - kegg.pathway: "sce00230" @@ -36846,6 +37078,7 @@ - gene_reaction_rule: "YLR245C" - eccodes: "3.5.4.5" - subsystem: + - "Pyrimidine metabolism" - annotation: !!omap - bigg.reaction: "DCYTD" - kegg.pathway: "sce00240" @@ -36866,6 +37099,7 @@ - gene_reaction_rule: "YDR454C" - eccodes: "2.7.4.8" - subsystem: + - "Purine metabolism" - annotation: !!omap - bigg.reaction: "DGK1" - kegg.pathway: "sce00230" @@ -36888,6 +37122,7 @@ - gene_reaction_rule: "YHR068W" - eccodes: "2.5.1.46" - subsystem: + - "Arginine and proline metabolism" - annotation: !!omap - metanetx.reaction: "MNXR136013" - sbo: "SBO:0000176" @@ -36906,6 +37141,7 @@ - gene_reaction_rule: "YCR036W" - eccodes: "2.7.1.15" - subsystem: + - "Pentose phosphate pathway" - annotation: !!omap - bigg.reaction: "DRBK" - kegg.pathway: "sce00030" @@ -36927,6 +37163,7 @@ - gene_reaction_rule: "YDR196C" - eccodes: "2.7.1.24" - subsystem: + - "Pantothenate and coa biosynthesis" - annotation: !!omap - bigg.reaction: "DPCOAKm" - kegg.pathway: "sce00770" @@ -36950,6 +37187,7 @@ - gene_reaction_rule: "YNR057C" - eccodes: "6.3.3.3" - subsystem: + - "Biotin metabolism" - annotation: !!omap - bigg.reaction: "DBTS" - kegg.pathway: "sce00780" @@ -36970,6 +37208,7 @@ - gene_reaction_rule: "YPL087W" - eccodes: "3.5.1.-" - subsystem: + - "Sphingolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00600" - metanetx.reaction: "MNXR126695" @@ -36991,6 +37230,7 @@ - gene_reaction_rule: "YPL087W" - eccodes: "3.5.1.-" - subsystem: + - "Sphingolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00600" - pubmed: @@ -37011,6 +37251,7 @@ - gene_reaction_rule: "YPL087W" - eccodes: "3.5.1.-" - subsystem: + - "Sphingolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00600" - metanetx.reaction: "MNXR126696" @@ -37032,6 +37273,7 @@ - gene_reaction_rule: "YPL087W" - eccodes: "3.5.1.-" - subsystem: + - "Sphingolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00600" - metanetx.reaction: "MNXR126694" @@ -37054,6 +37296,7 @@ - gene_reaction_rule: "YOR236W" - eccodes: "1.5.1.3" - subsystem: + - "Folate biosynthesis" - annotation: !!omap - bigg.reaction: "DHFR" - kegg.pathway: @@ -37077,6 +37320,7 @@ - gene_reaction_rule: "YOR236W" - eccodes: "1.5.1.3" - subsystem: + - "Folate biosynthesis" - annotation: !!omap - bigg.reaction: "DHFRim" - kegg.pathway: @@ -37102,6 +37346,7 @@ - gene_reaction_rule: "YMR113W" - eccodes: "6.3.2.12" - subsystem: + - "Folate biosynthesis" - annotation: !!omap - bigg.reaction: "DHFS" - kegg.pathway: "sce00790" @@ -37125,6 +37370,7 @@ - "2.7.6.3" - "4.1.2.25" - subsystem: + - "Folate biosynthesis" - annotation: !!omap - kegg.pathway: "sce00790" - kegg.reaction: "R03504" @@ -37144,6 +37390,7 @@ - gene_reaction_rule: "YDL100C" - eccodes: "3.6.-.-" - subsystem: + - "Folate biosynthesis" - annotation: !!omap - bigg.reaction: "DNMPPA" - kegg.reaction: "R04621" @@ -37163,6 +37410,7 @@ - gene_reaction_rule: "YLR420W" - eccodes: "3.5.2.3" - subsystem: + - "Pyrimidine metabolism" - annotation: !!omap - bigg.reaction: "DHORTS" - kegg.pathway: "sce00240" @@ -37187,6 +37435,7 @@ - "2.7.6.3" - "4.1.2.25" - subsystem: + - "Folate biosynthesis" - annotation: !!omap - kegg.pathway: "sce00790" - kegg.reaction: "R03066" @@ -37209,6 +37458,7 @@ - "2.7.6.3" - "4.1.2.25" - subsystem: + - "Folate biosynthesis" - annotation: !!omap - bigg.reaction: "FOLD3m" - kegg.pathway: "sce00790" @@ -37228,6 +37478,7 @@ - gene_reaction_rule: "YJR016C" - eccodes: "4.2.1.9" - subsystem: + - "Valine, leucine and isoleucine metabolism" - annotation: !!omap - bigg.reaction: "DHAD1m" - kegg.pathway: @@ -37254,6 +37505,7 @@ - gene_reaction_rule: "YJR016C" - eccodes: "4.2.1.9" - subsystem: + - "Valine, leucine and isoleucine metabolism" - annotation: !!omap - bigg.reaction: "DHAD2m" - kegg.pathway: @@ -37284,6 +37536,7 @@ - "2.7.1.28" - "2.7.1.29" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - bigg.reaction: "DHAK" - kegg.pathway: @@ -37309,6 +37562,7 @@ - "2.5.1.1" - "2.5.1.10" - subsystem: + - "Terpenoid backbone biosynthesis" - annotation: !!omap - bigg.reaction: "DMATT" - kegg.pathway: @@ -37331,6 +37585,7 @@ - gene_reaction_rule: "YKL152C" - eccodes: "5.4.2.11" - subsystem: + - "Glycolysis / gluconeogenesis" - annotation: !!omap - bigg.reaction: "DPGM" - kegg.pathway: @@ -37361,6 +37616,7 @@ - "3.6.1.52" - "3.6.1.60" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - pubmed: "10419486" - sbo: "SBO:0000176" @@ -37381,6 +37637,7 @@ - gene_reaction_rule: "YDR017C" - eccodes: "2.7.4.21" - subsystem: + - "Phosphatidylinositol signaling system" - annotation: !!omap - kegg.pathway: - "sce04070" @@ -37402,6 +37659,7 @@ - gene_reaction_rule: "YLR172C" - eccodes: "2.1.1.314" - subsystem: + - "Cysteine and methionine metabolism" - annotation: !!omap - bigg.reaction: "DIPS" - kegg.reaction: "R04481" @@ -37423,6 +37681,7 @@ - gene_reaction_rule: "YMR013C" - eccodes: "2.7.1.108" - subsystem: + - "N-glycan biosynthesis" - annotation: !!omap - bigg.reaction: "DOLK" - kegg.pathway: "sce00510" @@ -37444,6 +37703,7 @@ - gene_reaction_rule: "YPR183W" - eccodes: "2.4.1.83" - subsystem: + - "N-glycan biosynthesis" - annotation: !!omap - bigg.reaction: "DOLPMTcer" - kegg.pathway: "sce00510" @@ -37463,6 +37723,7 @@ - gene_reaction_rule: "(YAL023C and YDL095W) or YDL093W or YJR143C or YOR321W" - eccodes: "2.4.1.109" - subsystem: + - "N-glycan biosynthesis" - annotation: !!omap - bigg.reaction: "DOLPMMer" - kegg.pathway: @@ -37484,6 +37745,7 @@ - gene_reaction_rule: "YJR057W" - eccodes: "2.7.4.9" - subsystem: + - "Pyrimidine metabolism" - annotation: !!omap - bigg.reaction: "DTMPK" - kegg.pathway: "sce00240" @@ -37505,6 +37767,7 @@ - gene_reaction_rule: "YJR069C or YBR252W" - eccodes: "3.6.1.23" - subsystem: + - "Pyrimidine metabolism" - annotation: !!omap - bigg.reaction: "DUTPDP" - kegg.pathway: "sce00240" @@ -37524,6 +37787,7 @@ - gene_reaction_rule: "YJR153W" - eccodes: "3.2.1.15" - subsystem: + - "Pentose and glucuronate interconversions" - annotation: !!omap - bigg.reaction: "EPGALURSe" - kegg.pathway: "sce00040" @@ -37542,6 +37806,7 @@ - gene_reaction_rule: "YPL281C or YGR254W or YHR174W or YMR323W or YOR393W" - eccodes: "4.2.1.11" - subsystem: + - "Glycolysis / gluconeogenesis" - annotation: !!omap - bigg.reaction: "ENO" - kegg.pathway: @@ -37572,6 +37837,7 @@ - "2.7.1.32" - "2.7.1.82" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - bigg.reaction: "ETHAK" - kegg.pathway: "sce00564" @@ -37594,6 +37860,7 @@ - gene_reaction_rule: "YOR126C" - eccodes: "3.1.-.-" - subsystem: + - "Complex alcohol metabolism" - annotation: !!omap - metanetx.reaction: "MNXR121010" - pubmed: "10855721" @@ -37613,6 +37880,7 @@ - "3.2.1.58" - "3.2.1.6" - subsystem: + - "Starch and sucrose metabolism" - annotation: !!omap - bigg.reaction: "13BGHe" - kegg.pathway: "sce00500" @@ -37638,6 +37906,7 @@ - "2.5.1.10" - "2.5.1.29" - subsystem: + - "Terpenoid backbone biosynthesis" - annotation: !!omap - bigg.reaction: "FRTT" - kegg.pathway: @@ -37664,6 +37933,7 @@ - gene_reaction_rule: "YER015W" - eccodes: "6.2.1.3" - subsystem: + - "Fatty acid biosynthesis" - annotation: !!omap - kegg.pathway: - "sce00061" @@ -37688,6 +37958,7 @@ - gene_reaction_rule: "YER015W" - eccodes: "6.2.1.3" - subsystem: + - "Fatty acid biosynthesis" - annotation: !!omap - bigg.reaction: "FACOAL120p" - kegg.pathway: @@ -37713,6 +37984,7 @@ - gene_reaction_rule: "YER015W" - eccodes: "6.2.1.3" - subsystem: + - "Fatty acid biosynthesis" - annotation: !!omap - bigg.reaction: "FACOAL160p" - kegg.pathway: @@ -37739,6 +38011,7 @@ - gene_reaction_rule: "YER015W" - eccodes: "6.2.1.3" - subsystem: + - "Fatty acid biosynthesis" - annotation: !!omap - bigg.reaction: "FACOAL80p" - kegg.pathway: @@ -37764,6 +38037,7 @@ - gene_reaction_rule: "YER015W" - eccodes: "6.2.1.3" - subsystem: + - "Fatty acid biosynthesis" - annotation: !!omap - bigg.reaction: "FACOAL140p" - kegg.pathway: @@ -37787,6 +38061,7 @@ - gene_reaction_rule: "YOR176W" - eccodes: "4.99.1.1" - subsystem: + - "Porphyrin and chlorophyll metabolism" - annotation: !!omap - bigg.reaction: "FCLTm" - kegg.pathway: @@ -37809,6 +38084,7 @@ - gene_reaction_rule: "(YEL039C and YKR066C) or (YJR048W and YKR066C)" - eccodes: "1.11.1.5" - subsystem: + - "Oxidative phosphorylation" - annotation: !!omap - bigg.reaction: "CCP2m" - kegg.pathway: "sce00920" @@ -37831,6 +38107,7 @@ - gene_reaction_rule: "(Q0045 and Q0250 and Q0275 and YDL067C and YEL039C and YGL187C and YGL191W and YHR051W and YIL111W and YLR038C and YLR395C and YMR256C) or (Q0045 and Q0250 and Q0275 and YDL067C and YEL039C and YGL187C and YGL191W and YHR051W and YLR038C and YLR395C and YMR256C and YNL052W) or (Q0045 and Q0250 and Q0275 and YDL067C and YGL187C and YGL191W and YHR051W and YIL111W and YJR048W and YLR038C and YLR395C and YMR256C) or (Q0045 and Q0250 and Q0275 and YDL067C and YGL187C and YGL191W and YHR051W and YJR048W and YLR038C and YLR395C and YMR256C and YNL052W) or (Q0045 and Q0250 and Q0275 and YDL067C and YHR116W and YDR231C and YGR062C and YJL003W and YPL132W and YLL018C-A)" - eccodes: "1.9.3.1" - subsystem: + - "Oxidative phosphorylation" - annotation: !!omap - kegg.pathway: - "sce00190" @@ -37855,6 +38132,7 @@ - gene_reaction_rule: "(Q0105 and YBL045C and YDR529C and YEL024W and YEL039C and YFR033C and YGR183C and YHR001W-A and YJL166W and YOR065W and YPR191W) or (Q0105 and YBL045C and YDR529C and YEL024W and YFR033C and YGR183C and YHR001W-A and YJL166W and YJR048W and YOR065W and YPR191W)" - eccodes: "1.10.2.2" - subsystem: + - "Oxidative phosphorylation" - annotation: !!omap - kegg.pathway: - "sce00190" @@ -37875,6 +38153,7 @@ - gene_reaction_rule: "YDL045C" - eccodes: "2.7.7.2" - subsystem: + - "Riboflavin metabolism" - annotation: !!omap - bigg.reaction: "FMNAT" - kegg.pathway: @@ -37898,6 +38177,7 @@ - gene_reaction_rule: "YLR011W" - eccodes: "1.5.1.39" - subsystem: + - "Riboflavin metabolism" - annotation: !!omap - bigg.reaction: "FMNRx" - kegg.reaction: "R05705" @@ -37919,6 +38199,7 @@ - gene_reaction_rule: "YLR011W" - eccodes: "1.5.1.39" - subsystem: + - "Riboflavin metabolism" - annotation: !!omap - bigg.reaction: "FMNRx2" - kegg.reaction: "R05706" @@ -37944,6 +38225,7 @@ - "1.1.1.1" - "1.1.1.284" - subsystem: + - "Tyrosine metabolism" - annotation: !!omap - bigg.reaction: "FALDH" - kegg.pathway: @@ -37969,6 +38251,7 @@ - gene_reaction_rule: "YOR388C" - eccodes: "1.2.1.2" - subsystem: + - "Glyoxylate and dicarboxylate metabolism" - annotation: !!omap - bigg.reaction: "FDH" - kegg.pathway: @@ -37996,6 +38279,7 @@ - "3.5.4.9" - "6.3.4.3" - subsystem: + - "One carbon pool by folate" - annotation: !!omap - bigg.reaction: "FTHFLi" - kegg.pathway: "sce00670" @@ -38025,6 +38309,7 @@ - "3.5.4.9" - "6.3.4.3" - subsystem: + - "One carbon pool by folate" - annotation: !!omap - bigg.reaction: "FTHFLmi" - kegg.pathway: "sce00670" @@ -38049,6 +38334,7 @@ - gene_reaction_rule: "YLR345W or YJL155C" - eccodes: "3.1.3.46" - subsystem: + - "Fructose and mannose metabolism" - annotation: !!omap - bigg.reaction: "FBP26" - kegg.pathway: "sce00051" @@ -38069,6 +38355,7 @@ - gene_reaction_rule: "YLR377C" - eccodes: "3.1.3.11" - subsystem: + - "Glycolysis / gluconeogenesis" - annotation: !!omap - bigg.reaction: "FBP" - kegg.pathway: @@ -38094,6 +38381,7 @@ - gene_reaction_rule: "YKL060C" - eccodes: "4.1.2.13" - subsystem: + - "Glycolysis / gluconeogenesis" - annotation: !!omap - bigg.reaction: "FBA" - kegg.pathway: @@ -38120,6 +38408,7 @@ - gene_reaction_rule: "YPL262W" - eccodes: "4.2.1.2" - subsystem: + - "Citrate cycle (TCA cycle)" - annotation: !!omap - bigg.reaction: "FUMm" - kegg.pathway: @@ -38145,6 +38434,7 @@ - gene_reaction_rule: "YPL262W" - eccodes: "4.2.1.2" - subsystem: + - "Citrate cycle (TCA cycle)" - annotation: !!omap - bigg.reaction: "FUM" - kegg.pathway: @@ -38173,6 +38463,7 @@ - gene_reaction_rule: "YKL216W" - eccodes: "1.3.98.1" - subsystem: + - "Pyrimidine metabolism" - annotation: !!omap - bigg.reaction: "DHORDfum" - kegg.pathway: "sce00240" @@ -38195,6 +38486,7 @@ - gene_reaction_rule: "YEL047C" - eccodes: "1.3.1.6" - subsystem: + - "Citrate cycle (TCA cycle)" - annotation: !!omap - bigg.reaction: "FRDm" - kegg.reaction: "R00408" @@ -38219,6 +38511,7 @@ - gene_reaction_rule: "YEL047C" - eccodes: "1.3.1.6" - subsystem: + - "Cellular response to anaerobic conditions" - annotation: !!omap - bigg.reaction: "FRD" - kegg.reaction: "R00408" @@ -38241,6 +38534,7 @@ - "2.3.2.2" - "3.4.19.13" - subsystem: + - "Glutathione metabolism" - annotation: !!omap - bigg.reaction: "GTMLT" - kegg.pathway: @@ -38263,6 +38557,7 @@ - gene_reaction_rule: "YBR020W" - eccodes: "2.7.1.6" - subsystem: + - "Galactose metabolism" - annotation: !!omap - bigg.reaction: "GALKr" - kegg.pathway: @@ -38286,6 +38581,7 @@ - gene_reaction_rule: "YBR018C" - eccodes: "2.7.7.12" - subsystem: + - "Galactose metabolism" - annotation: !!omap - bigg.reaction: "GALT" - kegg.pathway: @@ -38311,6 +38607,7 @@ - gene_reaction_rule: "YJL101C" - eccodes: "6.3.2.2" - subsystem: + - "Glutathione metabolism" - annotation: !!omap - bigg.reaction: "GLUCYS" - kegg.pathway: @@ -38331,6 +38628,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Ubiquinone and other terpenoid-quinone biosynthesis" - annotation: !!omap - bigg.reaction: "GGTT" - kegg.reaction: "R07475" @@ -38353,6 +38651,7 @@ - "2.5.1.1" - "2.5.1.10" - subsystem: + - "Terpenoid backbone biosynthesis" - annotation: !!omap - bigg.reaction: "GRTT" - kegg.pathway: @@ -38377,6 +38676,7 @@ - "2.4.1.25" - "3.2.1.33" - subsystem: + - "Starch and sucrose metabolism" - annotation: !!omap - bigg.reaction: "GLCGSD" - kegg.pathway: @@ -38398,6 +38698,7 @@ - gene_reaction_rule: "YIL099W" - eccodes: "3.2.1.3" - subsystem: + - "Starch and sucrose metabolism" - annotation: !!omap - bigg.reaction: "GLCGSDv" - kegg.pathway: "sce00500" @@ -38416,6 +38717,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Amino sugar and nucleotide sugar metabolism" - annotation: !!omap - bigg.reaction: "G6PDA" - metanetx.reaction: "MNXR125024" @@ -38436,6 +38738,7 @@ - gene_reaction_rule: "YNL241C" - eccodes: "1.1.1.49" - subsystem: + - "Pentose phosphate pathway" - annotation: !!omap - bigg.reaction: "G6PDH2r" - kegg.pathway: @@ -38460,6 +38763,7 @@ - gene_reaction_rule: "YBR196C" - eccodes: "5.3.1.9" - subsystem: + - "Glycolysis / gluconeogenesis" - annotation: !!omap - bigg.reaction: "PGI" - kegg.pathway: @@ -38488,6 +38792,7 @@ - gene_reaction_rule: "YDR300C" - eccodes: "2.7.2.11" - subsystem: + - "Arginine and proline metabolism" - annotation: !!omap - bigg.reaction: "GLU5K" - kegg.pathway: @@ -38512,6 +38817,7 @@ - gene_reaction_rule: "YMR250W" - eccodes: "4.1.1.15" - subsystem: + - "Alanine, aspartate and glutamate metabolism" - annotation: !!omap - bigg.reaction: "GLUDC" - kegg.pathway: @@ -38541,6 +38847,7 @@ - gene_reaction_rule: "YDL215C" - eccodes: "1.4.1.2" - subsystem: + - "Alanine, aspartate and glutamate metabolism" - annotation: !!omap - bigg.reaction: "GLUDxi" - kegg.pathway: @@ -38569,6 +38876,7 @@ - gene_reaction_rule: "YAL062W or YOR375C" - eccodes: "1.4.1.4" - subsystem: + - "Alanine, aspartate and glutamate metabolism" - annotation: !!omap - bigg.reaction: "GLUDy" - kegg.pathway: @@ -38594,6 +38902,7 @@ - gene_reaction_rule: "YDL171C" - eccodes: "1.4.1.14" - subsystem: + - "Alanine, aspartate and glutamate metabolism" - annotation: !!omap - bigg.reaction: "GLUSx" - kegg.pathway: @@ -38622,6 +38931,7 @@ - gene_reaction_rule: "YOR323C" - eccodes: "1.2.1.41" - subsystem: + - "Arginine and proline metabolism" - annotation: !!omap - bigg.reaction: "G5SD" - kegg.pathway: @@ -38646,6 +38956,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YFL060C or YNL334C" - subsystem: + - "Alanine, aspartate and glutamate metabolism" - annotation: !!omap - bigg.reaction: "GLUN" - kegg.reaction: "R00256" @@ -38669,6 +38980,7 @@ - gene_reaction_rule: "YPR035W" - eccodes: "6.3.1.2" - subsystem: + - "Alanine, aspartate and glutamate metabolism" - annotation: !!omap - bigg.reaction: "GLNS" - kegg.pathway: @@ -38695,6 +39007,7 @@ - gene_reaction_rule: "YMR084W or YKL104C" - eccodes: "2.6.1.16" - subsystem: + - "Alanine, aspartate and glutamate metabolism" - annotation: !!omap - bigg.reaction: "GF6PTA" - kegg.pathway: @@ -38721,6 +39034,7 @@ - gene_reaction_rule: "YOR168W" - eccodes: "6.1.1.18" - subsystem: + - "tRNA metabolism" - annotation: !!omap - bigg.reaction: "GLNTRS" - kegg.pathway: "sce00970" @@ -38744,6 +39058,7 @@ - gene_reaction_rule: "YGL245W" - eccodes: "6.1.1.17" - subsystem: + - "tRNA metabolism" - annotation: !!omap - bigg.reaction: "GLUTRS" - kegg.pathway: @@ -38769,6 +39084,7 @@ - gene_reaction_rule: "YOL033W" - eccodes: "6.1.1.17" - subsystem: + - "tRNA metabolism" - annotation: !!omap - bigg.reaction: "GLUTRSm" - kegg.pathway: @@ -38794,6 +39110,7 @@ - gene_reaction_rule: "(YCL035C and YPL091W) or (YDR098C and YPL091W) or (YDR513W and YPL091W) or (YER174C and YPL091W)" - eccodes: "1.8.1.7" - subsystem: + - "Glutathione metabolism" - annotation: !!omap - bigg.reaction: "GTHOr" - kegg.pathway: "sce00480" @@ -38815,6 +39132,7 @@ - gene_reaction_rule: "YPL059W and YPL091W" - eccodes: "1.8.1.7" - subsystem: + - "Glutathione metabolism" - annotation: !!omap - bigg.reaction: "GTHOm" - kegg.pathway: "sce00480" @@ -38838,6 +39156,7 @@ - "1.11.1.15" - "1.11.1.9" - subsystem: + - "Glutathione metabolism" - annotation: !!omap - bigg.reaction: "GTHPi" - kegg.pathway: "sce00480" @@ -38857,6 +39176,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YPL059W" - subsystem: + - "Glutathione metabolism" - annotation: !!omap - bigg.reaction: "GTHPm" - kegg.reaction: "R00274" @@ -38880,6 +39200,7 @@ - gene_reaction_rule: "YOL049W" - eccodes: "6.3.2.3" - subsystem: + - "Glutathione metabolism" - annotation: !!omap - bigg.reaction: "GTHS" - kegg.pathway: @@ -38904,6 +39225,7 @@ - gene_reaction_rule: "YGR192C or YJL052W or YJR009C" - eccodes: "1.2.1.12" - subsystem: + - "Glycolysis / gluconeogenesis" - annotation: !!omap - bigg.reaction: "GAPD" - kegg.pathway: @@ -38931,6 +39253,7 @@ - gene_reaction_rule: "YOR120W" - eccodes: "1.1.1.156" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - bigg.reaction: "GLYCDy" - kegg.pathway: "sce00561" @@ -38953,6 +39276,7 @@ - gene_reaction_rule: "YHL032C" - eccodes: "2.7.1.30" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - bigg.reaction: "GLYK" - kegg.pathway: "sce00561" @@ -38973,6 +39297,7 @@ - gene_reaction_rule: "YER062C or YIL053W" - eccodes: "3.1.3.21" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - bigg.reaction: "G3PT" - kegg.pathway: "sce00561" @@ -38994,6 +39319,7 @@ - gene_reaction_rule: "YIL155C" - eccodes: "1.1.5.3" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - bigg.reaction: "G3PDm" - kegg.pathway: @@ -39017,6 +39343,7 @@ - gene_reaction_rule: "YDL022W or YOL059W" - eccodes: "1.1.1.8" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - bigg.reaction: "G3PD1ir" - kegg.pathway: @@ -39042,6 +39369,7 @@ - gene_reaction_rule: "YOL059W" - eccodes: "1.1.1.8" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - bigg.reaction: "G3PD1irm" - kegg.pathway: @@ -39066,6 +39394,7 @@ - gene_reaction_rule: "YPL110C" - eccodes: "3.1.4.46" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - bigg.reaction: "GPDDA1" - kegg.pathway: "sce00564" @@ -39088,6 +39417,7 @@ - gene_reaction_rule: "YDR408C" - eccodes: "2.1.2.2" - subsystem: + - "Purine metabolism" - annotation: !!omap - bigg.reaction: "GARFT" - kegg.pathway: @@ -39110,6 +39440,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Glycine, serine and threonine metabolism" - annotation: !!omap - bigg.reaction: "GLYAT" - kegg.reaction: "R00371" @@ -39136,6 +39467,7 @@ - "1.8.1.4" - "2.1.2.10" - subsystem: + - "Glycine, serine and threonine metabolism" - annotation: !!omap - bigg.reaction: "GLYCLm" - kegg.pathway: @@ -39166,6 +39498,7 @@ - gene_reaction_rule: "YLR058C" - eccodes: "2.1.2.1" - subsystem: + - "Glycine, serine and threonine metabolism" - annotation: !!omap - bigg.reaction: "GHMT2r" - kegg.pathway: @@ -39195,6 +39528,7 @@ - gene_reaction_rule: "YBR263W" - eccodes: "2.1.2.1" - subsystem: + - "Glycine, serine and threonine metabolism" - annotation: !!omap - bigg.reaction: "GHMT2rm" - kegg.pathway: @@ -39229,6 +39563,7 @@ - "1.8.1.4" - "2.1.2.10" - subsystem: + - "Glycine, serine and threonine metabolism" - annotation: !!omap - bigg.reaction: "GCC2am" - kegg.pathway: @@ -39265,6 +39600,7 @@ - "2.1.2.10" - "2.3.1.61" - subsystem: + - "Glycine, serine and threonine metabolism" - annotation: !!omap - bigg.reaction: "GCC2cm" - kegg.pathway: @@ -39301,6 +39637,7 @@ - "1.8.1.4" - "2.1.2.10" - subsystem: + - "Glycine, serine and threonine metabolism" - annotation: !!omap - bigg.reaction: "GCCam" - kegg.pathway: @@ -39337,6 +39674,7 @@ - "1.8.1.4" - "2.1.2.10" - subsystem: + - "Glycine, serine and threonine metabolism" - annotation: !!omap - bigg.reaction: "GCCbim" - kegg.pathway: @@ -39372,6 +39710,7 @@ - "1.8.1.4" - "2.1.2.10" - subsystem: + - "Glycine, serine and threonine metabolism" - annotation: !!omap - bigg.reaction: "GCCcm" - kegg.pathway: @@ -39407,6 +39746,7 @@ - "1.8.1.4" - "2.1.2.10" - subsystem: + - "Glycine, serine and threonine metabolism" - annotation: !!omap - bigg.reaction: "GCC2bim" - kegg.pathway: @@ -39438,6 +39778,7 @@ - "2.4.1.11" - "2.4.1.186" - subsystem: + - "Starch and sucrose metabolism" - annotation: !!omap - kegg.pathway: "sce00500" - metanetx.reaction: "MNXR143136" @@ -39456,6 +39797,7 @@ - gene_reaction_rule: "YPR160W" - eccodes: "2.4.1.1" - subsystem: + - "Starch and sucrose metabolism" - annotation: !!omap - bigg.reaction: "GLCP" - kegg.pathway: @@ -39479,6 +39821,7 @@ - gene_reaction_rule: "YBR121C or YPR081C" - eccodes: "6.1.1.14" - subsystem: + - "tRNA metabolism" - annotation: !!omap - bigg.reaction: "GLYTRS" - kegg.pathway: "sce00970" @@ -39505,6 +39848,7 @@ - gene_reaction_rule: "YMR217W" - eccodes: "6.3.5.2" - subsystem: + - "Purine metabolism" - annotation: !!omap - bigg.reaction: "GMPS2" - kegg.pathway: "sce00230" @@ -39526,6 +39870,7 @@ - gene_reaction_rule: "YMR281W" - eccodes: "3.5.1.89" - subsystem: + - "Glycosylphosphatidylinositol (gpi)-anchor biosynthesis" - annotation: !!omap - kegg.pathway: "sce00563" - kegg.reaction: "R05917" @@ -39546,6 +39891,7 @@ - gene_reaction_rule: "YCL052C and YJR013W" - eccodes: "2.4.1.-" - subsystem: + - "Glycosylphosphatidylinositol (gpi)-anchor biosynthesis" - annotation: !!omap - kegg.pathway: "sce00563" - pubmed: "11102867" @@ -39563,6 +39909,7 @@ - gene_reaction_rule: "YKL165C" - eccodes: "2.-.-.-" - subsystem: + - "Glycosylphosphatidylinositol (gpi)-anchor biosynthesis" - annotation: !!omap - kegg.pathway: "sce00563" - pubmed: "11102867" @@ -39581,6 +39928,7 @@ - gene_reaction_rule: "YBR004C" - eccodes: "2.4.1.-" - subsystem: + - "Glycosylphosphatidylinositol (gpi)-anchor biosynthesis" - annotation: !!omap - kegg.pathway: "sce00563" - pubmed: "15623507" @@ -39598,6 +39946,7 @@ - gene_reaction_rule: "YGL142C" - eccodes: "2.4.1.-" - subsystem: + - "Glycosylphosphatidylinositol (gpi)-anchor biosynthesis" - annotation: !!omap - kegg.pathway: "sce00563" - pubmed: "11102867" @@ -39616,6 +39965,7 @@ - gene_reaction_rule: "YDR302W or YLL031C" - eccodes: "2.-.-.-" - subsystem: + - "Glycosylphosphatidylinositol (gpi)-anchor biosynthesis" - annotation: !!omap - kegg.pathway: "sce00563" - pubmed: "10793139" @@ -39635,6 +39985,7 @@ - gene_reaction_rule: "YGR267C" - eccodes: "3.5.4.16" - subsystem: + - "Folate biosynthesis" - annotation: !!omap - bigg.reaction: "GTPCI" - kegg.pathway: "sce00790" @@ -39657,6 +40008,7 @@ - gene_reaction_rule: "YBL033C" - eccodes: "3.5.4.25" - subsystem: + - "Riboflavin metabolism" - annotation: !!omap - bigg.reaction: "GTPCII2" - kegg.pathway: @@ -39681,6 +40033,7 @@ - gene_reaction_rule: "YDL238C" - eccodes: "3.5.4.3" - subsystem: + - "Purine metabolism" - annotation: !!omap - bigg.reaction: "GUAD" - kegg.pathway: "sce00230" @@ -39702,6 +40055,7 @@ - gene_reaction_rule: "YDR399W" - eccodes: "2.4.2.8" - subsystem: + - "Purine metabolism" - annotation: !!omap - bigg.reaction: "GUAPRT" - kegg.pathway: @@ -39724,6 +40078,7 @@ - gene_reaction_rule: "YDR454C" - eccodes: "2.7.4.8" - subsystem: + - "Purine metabolism" - annotation: !!omap - bigg.reaction: "GK1" - kegg.pathway: "sce00230" @@ -39744,6 +40099,7 @@ - gene_reaction_rule: "YDR454C" - eccodes: "2.7.4.8" - subsystem: + - "Purine metabolism" - annotation: !!omap - bigg.reaction: "GK2" - kegg.pathway: "sce00230" @@ -39765,6 +40121,7 @@ - gene_reaction_rule: "YER141W or (YDR376W and YPL252C)" - eccodes: "1.18.1.6" - subsystem: + - "Porphyrin and chlorophyll metabolism" - annotation: !!omap - bigg.reaction: "HEMEOMOm" - metanetx.reaction: "MNXR100595" @@ -39785,6 +40142,7 @@ - gene_reaction_rule: "YPL172C" - eccodes: "2.5.1.-" - subsystem: + - "Porphyrin and chlorophyll metabolism" - annotation: !!omap - bigg.reaction: "HEMEOSm" - kegg.pathway: @@ -39807,7 +40165,7 @@ - s_1535: 1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "YDR204W and YGL119W and YGR255C and YLR201C and YML110C and YOL096C and YOR125C" + - gene_reaction_rule: "YDR204W and YGR255C and YLR201C and YML110C and YOL096C and YOR125C" - eccodes: - "1.14.13.-" - "2.1.1.114" @@ -39815,6 +40173,7 @@ - "2.1.1.64" - "2.7.-.-" - subsystem: + - "Ubiquinone and other terpenoid-quinone biosynthesis" - annotation: !!omap - kegg.pathway: - "sce00130" @@ -39835,6 +40194,7 @@ - gene_reaction_rule: "YLR446W or YFR053C or YGL253W" - eccodes: "2.7.1.1" - subsystem: + - "Glycolysis / gluconeogenesis" - annotation: !!omap - bigg.reaction: "HEX7" - kegg.pathway: @@ -39866,6 +40226,7 @@ - "2.7.1.1" - "2.7.1.2" - subsystem: + - "Glycolysis / gluconeogenesis" - annotation: !!omap - bigg.reaction: "HEX1" - kegg.pathway: @@ -39896,6 +40257,7 @@ - gene_reaction_rule: "YLR446W or YFR053C or YGL253W" - eccodes: "2.7.1.1" - subsystem: + - "Glycolysis / gluconeogenesis" - annotation: !!omap - bigg.reaction: "HEX4" - kegg.pathway: @@ -39929,6 +40291,7 @@ - "3.5.4.19" - "3.6.1.31" - subsystem: + - "Histidine metabolism" - annotation: !!omap - bigg.reaction: "HISTD" - kegg.pathway: @@ -39952,6 +40315,7 @@ - gene_reaction_rule: "YFR025C" - eccodes: "3.1.3.15" - subsystem: + - "Histidine metabolism" - annotation: !!omap - bigg.reaction: "HISTP" - kegg.pathway: @@ -39975,6 +40339,7 @@ - gene_reaction_rule: "YIL116W" - eccodes: "2.6.1.9" - subsystem: + - "Histidine metabolism" - annotation: !!omap - bigg.reaction: "HSTPT" - kegg.pathway: @@ -40004,6 +40369,7 @@ - gene_reaction_rule: "YPR033C" - eccodes: "6.1.1.21" - subsystem: + - "tRNA metabolism" - annotation: !!omap - bigg.reaction: "HISTRS" - kegg.pathway: "sce00970" @@ -40027,6 +40393,7 @@ - gene_reaction_rule: "YPR033C" - eccodes: "6.1.1.21" - subsystem: + - "tRNA metabolism" - annotation: !!omap - bigg.reaction: "HISTRSm" - kegg.pathway: "sce00970" @@ -40049,6 +40416,7 @@ - gene_reaction_rule: "YBR034C" - eccodes: "2.1.1.-" - subsystem: + - "Histidine metabolism" - annotation: !!omap - bigg.reaction: "ARMT" - kegg.reaction: "R01159" @@ -40068,6 +40436,7 @@ - gene_reaction_rule: "YJL200C or YDR234W" - eccodes: "4.2.1.36" - subsystem: + - "Lysine metabolism" - annotation: !!omap - bigg.reaction: "HACNHm" - kegg.pathway: @@ -40095,6 +40464,7 @@ - gene_reaction_rule: "YDL131W or YDL182W" - eccodes: "2.3.3.14" - subsystem: + - "Pyruvate metabolism" - annotation: !!omap - kegg.pathway: - "sce00300" @@ -40120,6 +40490,7 @@ - gene_reaction_rule: "YLL062C or YPL273W" - eccodes: "2.1.1.10" - subsystem: + - "Cysteine and methionine metabolism" - annotation: !!omap - bigg.reaction: "HCYSMT" - kegg.pathway: @@ -40144,6 +40515,7 @@ - gene_reaction_rule: "YIL094C" - eccodes: "1.1.1.87" - subsystem: + - "Lysine metabolism" - annotation: !!omap - kegg.pathway: - "sce00300" @@ -40169,6 +40541,7 @@ - gene_reaction_rule: "YJR139C" - eccodes: "1.1.1.3" - subsystem: + - "Glycine, serine and threonine metabolism" - annotation: !!omap - bigg.reaction: "HSDxi" - kegg.pathway: @@ -40199,6 +40572,7 @@ - gene_reaction_rule: "YJR139C" - eccodes: "1.1.1.3" - subsystem: + - "Glycine, serine and threonine metabolism" - annotation: !!omap - bigg.reaction: "HSDy" - kegg.pathway: @@ -40227,6 +40601,7 @@ - gene_reaction_rule: "YHR025W" - eccodes: "2.7.1.39" - subsystem: + - "Glycine, serine and threonine metabolism" - annotation: !!omap - bigg.reaction: "HSK" - kegg.pathway: @@ -40251,6 +40626,7 @@ - gene_reaction_rule: "YNL277W" - eccodes: "2.3.1.31" - subsystem: + - "Cysteine and methionine metabolism" - annotation: !!omap - bigg.reaction: "HSERTA" - kegg.pathway: @@ -40275,6 +40651,7 @@ - gene_reaction_rule: "(YDR453C and YGR209C) or (YDR453C and YLR043C)" - eccodes: "1.11.1.15" - subsystem: + - "Glutathione metabolism" - annotation: !!omap - bigg.reaction: "THIORDXi" - metanetx.reaction: "MNXR104815" @@ -40295,6 +40672,7 @@ - gene_reaction_rule: "YBL064C and YCR083W" - eccodes: "1.11.1.15" - subsystem: + - "Glutathione metabolism" - annotation: !!omap - bigg.reaction: "THIORDXm" - metanetx.reaction: "MNXR104815" @@ -40315,6 +40693,7 @@ - gene_reaction_rule: "(YGR209C and YLR109W) or (YLR043C and YLR109W)" - eccodes: "1.11.1.15" - subsystem: + - "Glutathione metabolism" - annotation: !!omap - bigg.reaction: "THIORDXp" - kegg.pathway: "sce04122" @@ -40336,6 +40715,7 @@ - gene_reaction_rule: "YDR272W" - eccodes: "3.1.2.6" - subsystem: + - "Pyruvate metabolism" - annotation: !!omap - bigg.reaction: "GLYOX" - kegg.pathway: "sce00620" @@ -40357,6 +40737,7 @@ - gene_reaction_rule: "YOR040W" - eccodes: "3.1.2.6" - subsystem: + - "Pyruvate metabolism" - annotation: !!omap - bigg.reaction: "GLYOXm" - kegg.pathway: "sce00620" @@ -40377,6 +40758,7 @@ - gene_reaction_rule: "YNR041C" - eccodes: "2.5.1.39" - subsystem: + - "Ubiquinone and other terpenoid-quinone biosynthesis" - annotation: !!omap - bigg.reaction: "HBZOPT6m" - kegg.pathway: @@ -40402,6 +40784,7 @@ - "2.5.1.3" - "2.7.1.50" - subsystem: + - "Thiamine metabolism" - annotation: !!omap - bigg.reaction: "HETZK" - kegg.pathway: "sce00730" @@ -40422,6 +40805,7 @@ - gene_reaction_rule: "YDL205C" - eccodes: "2.5.1.61" - subsystem: + - "Porphyrin and chlorophyll metabolism" - annotation: !!omap - bigg.reaction: "HMBS" - kegg.pathway: @@ -40446,6 +40830,7 @@ - gene_reaction_rule: "YLR450W or YML075C" - eccodes: "1.1.1.34" - subsystem: + - "Terpenoid backbone biosynthesis" - annotation: !!omap - bigg.reaction: "HMGCOAR" - kegg.pathway: @@ -40471,6 +40856,7 @@ - gene_reaction_rule: "YML126C" - eccodes: "2.3.3.10" - subsystem: + - "Terpenoid backbone biosynthesis" - annotation: !!omap - bigg.reaction: "HMGCOAS" - kegg.pathway: @@ -40499,6 +40885,7 @@ - gene_reaction_rule: "YML126C" - eccodes: "2.3.3.10" - subsystem: + - "Terpenoid backbone biosynthesis" - annotation: !!omap - bigg.reaction: "HMGCOASm" - kegg.pathway: @@ -40528,6 +40915,7 @@ - "2.7.1.49" - "2.7.4.7" - subsystem: + - "Thiamine metabolism" - annotation: !!omap - bigg.reaction: "HMPK1" - kegg.pathway: "sce00730" @@ -40548,6 +40936,7 @@ - gene_reaction_rule: "YDR399W" - eccodes: "2.4.2.8" - subsystem: + - "Purine metabolism" - annotation: !!omap - bigg.reaction: "HXPRT" - kegg.pathway: @@ -40574,6 +40963,7 @@ - "2.4.2.-" - "4.1.3.-" - subsystem: + - "Histidine metabolism" - annotation: !!omap - bigg.reaction: "IG3PS" - kegg.pathway: @@ -40596,6 +40986,7 @@ - gene_reaction_rule: "YOR202W" - eccodes: "4.2.1.19" - subsystem: + - "Histidine metabolism" - annotation: !!omap - bigg.reaction: "IGPDH" - kegg.pathway: @@ -40621,6 +41012,7 @@ - gene_reaction_rule: "YHR216W or YLR432W or YML056C" - eccodes: "1.1.1.205" - subsystem: + - "Purine metabolism" - annotation: !!omap - bigg.reaction: "IMPD" - kegg.pathway: @@ -40647,6 +41039,7 @@ - "4.1.1.48" - "4.1.3.27" - subsystem: + - "Phenylalanine, tyrosine and tryptophan biosynthesis" - annotation: !!omap - bigg.reaction: "IGPS" - kegg.pathway: @@ -40676,6 +41069,7 @@ - "4.1.1.43" - "4.1.1.74" - subsystem: + - "Tryptophan metabolism" - annotation: !!omap - bigg.reaction: "INDPYRD" - kegg.pathway: @@ -40700,6 +41094,7 @@ - gene_reaction_rule: "YBR011C" - eccodes: "3.6.1.1" - subsystem: + - "Oxidative phosphorylation" - annotation: !!omap - bigg.reaction: "PPA" - kegg.pathway: "sce00190" @@ -40721,6 +41116,7 @@ - gene_reaction_rule: "YMR267W" - eccodes: "3.6.1.1" - subsystem: + - "Oxidative phosphorylation" - annotation: !!omap - bigg.reaction: "PPAm" - kegg.pathway: "sce00190" @@ -40743,6 +41139,7 @@ - "2.1.2.3" - "3.5.4.10" - subsystem: + - "Purine metabolism" - annotation: !!omap - bigg.reaction: "IMPC" - kegg.pathway: @@ -40768,6 +41165,7 @@ - gene_reaction_rule: "YDR315C" - eccodes: "2.7.1.158" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -40791,6 +41189,7 @@ - gene_reaction_rule: "YDR173C" - eccodes: "2.7.1.151" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -40815,6 +41214,7 @@ - gene_reaction_rule: "YDR173C" - eccodes: "2.7.1.151" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -40839,6 +41239,7 @@ - gene_reaction_rule: "YDR173C" - eccodes: "2.7.1.151" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -40863,6 +41264,7 @@ - gene_reaction_rule: "YDR173C" - eccodes: "2.7.1.151" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -40886,6 +41288,7 @@ - gene_reaction_rule: "YER019W" - eccodes: "3.1.4.-" - subsystem: + - "Sphingolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00600" - pubmed: @@ -40906,6 +41309,7 @@ - gene_reaction_rule: "YER019W" - eccodes: "3.1.4.-" - subsystem: + - "Sphingolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00600" - pubmed: @@ -40926,6 +41330,7 @@ - gene_reaction_rule: "YER019W" - eccodes: "3.1.4.-" - subsystem: + - "Sphingolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00600" - pubmed: @@ -40946,6 +41351,7 @@ - gene_reaction_rule: "YER019W" - eccodes: "3.1.4.-" - subsystem: + - "Sphingolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00600" - pubmed: @@ -40966,6 +41372,7 @@ - gene_reaction_rule: "YER019W" - eccodes: "3.1.4.-" - subsystem: + - "Sphingolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00600" - pubmed: @@ -40986,6 +41393,7 @@ - gene_reaction_rule: "YER019W" - eccodes: "3.1.4.-" - subsystem: + - "Sphingolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00600" - pubmed: @@ -41006,6 +41414,7 @@ - gene_reaction_rule: "YER019W" - eccodes: "3.1.4.-" - subsystem: + - "Sphingolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00600" - pubmed: @@ -41026,6 +41435,7 @@ - gene_reaction_rule: "YER019W" - eccodes: "3.1.4.-" - subsystem: + - "Sphingolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00600" - pubmed: @@ -41046,6 +41456,7 @@ - gene_reaction_rule: "YER019W" - eccodes: "3.1.4.-" - subsystem: + - "Sphingolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00600" - pubmed: @@ -41066,6 +41477,7 @@ - gene_reaction_rule: "YER019W" - eccodes: "3.1.4.-" - subsystem: + - "Sphingolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00600" - pubmed: @@ -41086,6 +41498,7 @@ - gene_reaction_rule: "YER019W" - eccodes: "3.1.4.-" - subsystem: + - "Sphingolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00600" - pubmed: @@ -41106,6 +41519,7 @@ - gene_reaction_rule: "YER019W" - eccodes: "3.1.4.-" - subsystem: + - "Sphingolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00600" - pubmed: @@ -41126,6 +41540,7 @@ - gene_reaction_rule: "YER019W" - eccodes: "3.1.4.-" - subsystem: + - "Sphingolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00600" - pubmed: @@ -41146,6 +41561,7 @@ - gene_reaction_rule: "YER019W" - eccodes: "3.1.4.-" - subsystem: + - "Sphingolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00600" - pubmed: @@ -41166,6 +41582,7 @@ - gene_reaction_rule: "YER019W" - eccodes: "3.1.4.-" - subsystem: + - "Sphingolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00600" - pubmed: @@ -41186,6 +41603,7 @@ - gene_reaction_rule: "YER019W" - eccodes: "3.1.4.-" - subsystem: + - "Sphingolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00600" - pubmed: @@ -41206,6 +41624,7 @@ - gene_reaction_rule: "YER019W" - eccodes: "3.1.4.-" - subsystem: + - "Sphingolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00600" - pubmed: @@ -41226,6 +41645,7 @@ - gene_reaction_rule: "YER019W" - eccodes: "3.1.4.-" - subsystem: + - "Sphingolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00600" - pubmed: @@ -41246,6 +41666,7 @@ - gene_reaction_rule: "YER019W" - eccodes: "3.1.4.-" - subsystem: + - "Sphingolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00600" - pubmed: @@ -41266,6 +41687,7 @@ - gene_reaction_rule: "YER019W" - eccodes: "3.1.4.-" - subsystem: + - "Sphingolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00600" - pubmed: @@ -41287,6 +41709,7 @@ - gene_reaction_rule: "YER019W" - eccodes: "3.1.4.-" - subsystem: + - "Sphingolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00600" - pubmed: @@ -41308,6 +41731,7 @@ - gene_reaction_rule: "YER019W" - eccodes: "3.1.4.-" - subsystem: + - "Sphingolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00600" - pubmed: @@ -41329,6 +41753,7 @@ - gene_reaction_rule: "YER019W" - eccodes: "3.1.4.-" - subsystem: + - "Sphingolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00600" - pubmed: @@ -41350,6 +41775,7 @@ - gene_reaction_rule: "YER019W" - eccodes: "3.1.4.-" - subsystem: + - "Sphingolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00600" - pubmed: @@ -41371,6 +41797,7 @@ - gene_reaction_rule: "YER019W" - eccodes: "3.1.4.-" - subsystem: + - "Sphingolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00600" - pubmed: @@ -41392,6 +41819,7 @@ - gene_reaction_rule: "YER019W" - eccodes: "3.1.4.-" - subsystem: + - "Sphingolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00600" - pubmed: @@ -41413,6 +41841,7 @@ - gene_reaction_rule: "YER019W" - eccodes: "3.1.4.-" - subsystem: + - "Sphingolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00600" - pubmed: @@ -41434,6 +41863,7 @@ - gene_reaction_rule: "YER019W" - eccodes: "3.1.4.-" - subsystem: + - "Sphingolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00600" - pubmed: @@ -41455,6 +41885,7 @@ - gene_reaction_rule: "YER019W" - eccodes: "3.1.4.-" - subsystem: + - "Sphingolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00600" - pubmed: @@ -41476,6 +41907,7 @@ - gene_reaction_rule: "YER019W" - eccodes: "3.1.4.-" - subsystem: + - "Sphingolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00600" - pubmed: @@ -41496,6 +41928,7 @@ - gene_reaction_rule: "YER019W" - eccodes: "3.1.4.-" - subsystem: + - "Sphingolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00600" - pubmed: @@ -41516,6 +41949,7 @@ - gene_reaction_rule: "YER019W" - eccodes: "3.1.4.-" - subsystem: + - "Sphingolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00600" - pubmed: @@ -41536,6 +41970,7 @@ - gene_reaction_rule: "YER019W" - eccodes: "3.1.4.-" - subsystem: + - "Sphingolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00600" - pubmed: @@ -41556,6 +41991,7 @@ - gene_reaction_rule: "YER019W" - eccodes: "3.1.4.-" - subsystem: + - "Sphingolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00600" - pubmed: @@ -41576,6 +42012,7 @@ - gene_reaction_rule: "YER019W" - eccodes: "3.1.4.-" - subsystem: + - "Sphingolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00600" - pubmed: @@ -41596,6 +42033,7 @@ - gene_reaction_rule: "YER019W" - eccodes: "3.1.4.-" - subsystem: + - "Sphingolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00600" - pubmed: @@ -41616,6 +42054,7 @@ - gene_reaction_rule: "YER019W" - eccodes: "3.1.4.-" - subsystem: + - "Sphingolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00600" - pubmed: @@ -41636,6 +42075,7 @@ - gene_reaction_rule: "YER019W" - eccodes: "3.1.4.-" - subsystem: + - "Sphingolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00600" - pubmed: @@ -41656,6 +42096,7 @@ - gene_reaction_rule: "YER019W" - eccodes: "3.1.4.-" - subsystem: + - "Sphingolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00600" - pubmed: @@ -41676,6 +42117,7 @@ - gene_reaction_rule: "YER019W" - eccodes: "3.1.4.-" - subsystem: + - "Sphingolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00600" - pubmed: @@ -41696,6 +42138,7 @@ - gene_reaction_rule: "YER019W" - eccodes: "3.1.4.-" - subsystem: + - "Sphingolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00600" - pubmed: @@ -41716,6 +42159,7 @@ - gene_reaction_rule: "YER019W" - eccodes: "3.1.4.-" - subsystem: + - "Sphingolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00600" - pubmed: @@ -41736,6 +42180,7 @@ - gene_reaction_rule: "YER019W" - eccodes: "3.1.4.-" - subsystem: + - "Sphingolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00600" - pubmed: @@ -41756,6 +42201,7 @@ - gene_reaction_rule: "YER019W" - eccodes: "3.1.4.-" - subsystem: + - "Sphingolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00600" - pubmed: @@ -41776,6 +42222,7 @@ - gene_reaction_rule: "YER019W" - eccodes: "3.1.4.-" - subsystem: + - "Sphingolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00600" - pubmed: @@ -41796,6 +42243,7 @@ - gene_reaction_rule: "YER019W" - eccodes: "3.1.4.-" - subsystem: + - "Sphingolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00600" - pubmed: @@ -41816,6 +42264,7 @@ - gene_reaction_rule: "YER019W" - eccodes: "3.1.4.-" - subsystem: + - "Sphingolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00600" - pubmed: @@ -41836,6 +42285,7 @@ - gene_reaction_rule: "YER019W" - eccodes: "3.1.4.-" - subsystem: + - "Sphingolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00600" - pubmed: @@ -41856,6 +42306,7 @@ - gene_reaction_rule: "YER019W" - eccodes: "3.1.4.-" - subsystem: + - "Sphingolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00600" - pubmed: @@ -41876,6 +42327,7 @@ - gene_reaction_rule: "YER019W" - eccodes: "3.1.4.-" - subsystem: + - "Sphingolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00600" - pubmed: @@ -41897,6 +42349,7 @@ - gene_reaction_rule: "YER019W" - eccodes: "3.1.4.-" - subsystem: + - "Sphingolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00600" - pubmed: @@ -41918,6 +42371,7 @@ - gene_reaction_rule: "YER019W" - eccodes: "3.1.4.-" - subsystem: + - "Sphingolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00600" - pubmed: @@ -41939,6 +42393,7 @@ - gene_reaction_rule: "YER019W" - eccodes: "3.1.4.-" - subsystem: + - "Sphingolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00600" - pubmed: @@ -41960,6 +42415,7 @@ - gene_reaction_rule: "YER019W" - eccodes: "3.1.4.-" - subsystem: + - "Sphingolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00600" - pubmed: @@ -41981,6 +42437,7 @@ - gene_reaction_rule: "YER019W" - eccodes: "3.1.4.-" - subsystem: + - "Sphingolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00600" - pubmed: @@ -42002,6 +42459,7 @@ - gene_reaction_rule: "YER019W" - eccodes: "3.1.4.-" - subsystem: + - "Sphingolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00600" - pubmed: @@ -42023,6 +42481,7 @@ - gene_reaction_rule: "YER019W" - eccodes: "3.1.4.-" - subsystem: + - "Sphingolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00600" - pubmed: @@ -42044,6 +42503,7 @@ - gene_reaction_rule: "YER019W" - eccodes: "3.1.4.-" - subsystem: + - "Sphingolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00600" - pubmed: @@ -42065,6 +42525,7 @@ - gene_reaction_rule: "YER019W" - eccodes: "3.1.4.-" - subsystem: + - "Sphingolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00600" - pubmed: @@ -42086,6 +42547,7 @@ - gene_reaction_rule: "YER019W" - eccodes: "3.1.4.-" - subsystem: + - "Sphingolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00600" - pubmed: @@ -42107,6 +42569,7 @@ - gene_reaction_rule: "YOR126C" - eccodes: "3.1.-.-" - subsystem: + - "Complex alcohol metabolism" - annotation: !!omap - bigg.reaction: "ACHLE1" - metanetx.reaction: "MNXR95262" @@ -42127,6 +42590,7 @@ - gene_reaction_rule: "YOR126C" - eccodes: "3.1.-.-" - subsystem: + - "Complex alcohol metabolism" - annotation: !!omap - bigg.reaction: "ACHLE2" - metanetx.reaction: "MNXR95263" @@ -42147,6 +42611,7 @@ - gene_reaction_rule: "YNL037C and YOR136W" - eccodes: "1.1.1.41" - subsystem: + - "Citrate cycle (TCA cycle)" - annotation: !!omap - bigg.reaction: "ICDHxm" - kegg.pathway: @@ -42175,6 +42640,7 @@ - gene_reaction_rule: "YLR174W" - eccodes: "1.1.1.42" - subsystem: + - "Citrate cycle (TCA cycle)" - annotation: !!omap - bigg.reaction: "ICDHyr" - kegg.pathway: @@ -42205,6 +42671,7 @@ - gene_reaction_rule: "YNL009W" - eccodes: "1.1.1.42" - subsystem: + - "Citrate cycle (TCA cycle)" - annotation: !!omap - bigg.reaction: "ICDHyp" - kegg.pathway: @@ -42235,6 +42702,7 @@ - "4.1.3.1" - "4.1.3.30" - subsystem: + - "Glyoxylate and dicarboxylate metabolism" - annotation: !!omap - bigg.reaction: "ICL" - kegg.pathway: @@ -42258,6 +42726,7 @@ - gene_reaction_rule: "YJR148W" - eccodes: "2.6.1.42" - subsystem: + - "Valine, leucine and isoleucine metabolism" - annotation: !!omap - bigg.reaction: "ILETA" - kegg.pathway: @@ -42287,6 +42756,7 @@ - gene_reaction_rule: "YHR208W" - eccodes: "2.6.1.42" - subsystem: + - "Valine, leucine and isoleucine metabolism" - annotation: !!omap - bigg.reaction: "ILETAm" - kegg.pathway: @@ -42318,6 +42788,7 @@ - gene_reaction_rule: "YBL076C" - eccodes: "6.1.1.5" - subsystem: + - "tRNA metabolism" - annotation: !!omap - bigg.reaction: "ILETRS" - kegg.pathway: "sce00970" @@ -42341,6 +42812,7 @@ - gene_reaction_rule: "YPL040C" - eccodes: "6.1.1.5" - subsystem: + - "tRNA metabolism" - annotation: !!omap - bigg.reaction: "ILETRSm" - kegg.pathway: "sce00970" @@ -42360,6 +42832,7 @@ - gene_reaction_rule: "YPL117C" - eccodes: "5.3.3.2" - subsystem: + - "Terpenoid backbone biosynthesis" - annotation: !!omap - bigg.reaction: "IPDDI" - kegg.pathway: @@ -42385,6 +42858,7 @@ - gene_reaction_rule: "YGR244C and YOR142W" - eccodes: "6.2.1.5" - subsystem: + - "C5-branched dibasic acid metabolism" - annotation: !!omap - bigg.reaction: "ITCOALm" - kegg.pathway: @@ -42412,6 +42886,7 @@ - gene_reaction_rule: "YLR355C" - eccodes: "1.1.1.86" - subsystem: + - "Valine, leucine and isoleucine metabolism" - annotation: !!omap - bigg.reaction: "KARA2im" - kegg.pathway: @@ -42439,6 +42914,7 @@ - gene_reaction_rule: "YLR231C" - eccodes: "3.7.1.3" - subsystem: + - "Tryptophan metabolism" - annotation: !!omap - bigg.reaction: "KYN" - kegg.pathway: "sce00380" @@ -42463,6 +42939,7 @@ - gene_reaction_rule: "YBL098W" - eccodes: "1.14.13.9" - subsystem: + - "Tryptophan metabolism" - annotation: !!omap - bigg.reaction: "KYN3OX" - kegg.pathway: "sce00380" @@ -42486,6 +42963,7 @@ - gene_reaction_rule: "YHR037W" - eccodes: "1.2.1.88" - subsystem: + - "Arginine and proline metabolism" - annotation: !!omap - bigg.reaction: "PHCDm" - kegg.pathway: @@ -42510,6 +42988,7 @@ - gene_reaction_rule: "YHR037W" - eccodes: "1.2.1.88" - subsystem: + - "Arginine and proline metabolism" - annotation: !!omap - bigg.reaction: "4HGLSDm" - kegg.pathway: @@ -42532,6 +43011,7 @@ - gene_reaction_rule: "YLR089C" - eccodes: "2.6.1.2" - subsystem: + - "Alanine, aspartate and glutamate metabolism" - annotation: !!omap - bigg.reaction: "ALATA_Lm" - kegg.pathway: @@ -42556,6 +43036,7 @@ - gene_reaction_rule: "YEL046C" - eccodes: "4.1.2.48" - subsystem: + - "Glycine, serine and threonine metabolism" - annotation: !!omap - bigg.reaction: "THRA2" - kegg.pathway: @@ -42582,6 +43063,7 @@ - gene_reaction_rule: "YMR226C" - eccodes: "1.1.1.381" - subsystem: + - "Glycine, serine and threonine metabolism" - annotation: !!omap - bigg.reaction: "ATHRDHr" - kegg.pathway: @@ -42612,6 +43094,7 @@ - "1.2.1.95" - "2.7.8.7" - subsystem: + - "Lysine metabolism" - annotation: !!omap - bigg.reaction: "AASAD1" - kegg.pathway: @@ -42637,6 +43120,7 @@ - gene_reaction_rule: "YDR321W" - eccodes: "3.5.1.1" - subsystem: + - "Alanine, aspartate and glutamate metabolism" - annotation: !!omap - bigg.reaction: "ASNN" - kegg.pathway: @@ -42660,6 +43144,7 @@ - gene_reaction_rule: "YLR155C or YLR157C or YLR158C or YLR160C" - eccodes: "3.5.1.1" - subsystem: + - "Alanine, aspartate and glutamate metabolism" - annotation: !!omap - bigg.reaction: "ASNNe" - kegg.reaction: "R00485" @@ -42680,6 +43165,7 @@ - gene_reaction_rule: "YLR027C" - eccodes: "2.6.1.1" - subsystem: + - "Arginine and proline metabolism" - annotation: !!omap - bigg.reaction: "EHGLAT" - kegg.pathway: @@ -42712,6 +43198,7 @@ - gene_reaction_rule: "YKL106W" - eccodes: "2.6.1.1" - subsystem: + - "Arginine and proline metabolism" - annotation: !!omap - bigg.reaction: "EHGLATm" - kegg.pathway: @@ -42744,6 +43231,7 @@ - gene_reaction_rule: "YLR027C" - eccodes: "2.6.1.1" - subsystem: + - "Arginine and proline metabolism" - annotation: !!omap - bigg.reaction: "EHGLATp" - kegg.pathway: @@ -42777,6 +43265,7 @@ - gene_reaction_rule: "YER023W" - eccodes: "1.5.1.2" - subsystem: + - "Arginine and proline metabolism" - annotation: !!omap - kegg.reaction: "R03293" - metanetx.reaction: "MNXR100699" @@ -42800,6 +43289,7 @@ - "1.1.1.265" - "1.1.1.283" - subsystem: + - "Pyruvate metabolism" - annotation: !!omap - bigg.reaction: "LALDO3" - kegg.pathway: @@ -42826,6 +43316,7 @@ - "4.3.1.17" - "4.3.1.19" - subsystem: + - "Glycine, serine and threonine metabolism" - annotation: !!omap - bigg.reaction: "SERD_L" - kegg.pathway: @@ -42855,6 +43346,7 @@ - gene_reaction_rule: "YMR226C" - eccodes: "1.1.1.381" - subsystem: + - "Glycine, serine and threonine metabolism" - annotation: !!omap - bigg.reaction: "LSERDHr" - kegg.pathway: @@ -42879,6 +43371,7 @@ - gene_reaction_rule: "YJR159W" - eccodes: "1.1.1.14" - subsystem: + - "Fructose and mannose metabolism" - annotation: !!omap - bigg.reaction: "SBTD_L" - kegg.pathway: @@ -42901,6 +43394,7 @@ - "4.3.1.17" - "4.3.1.19" - subsystem: + - "Glycine, serine and threonine metabolism" - annotation: !!omap - bigg.reaction: "THRD_L" - kegg.pathway: @@ -42928,6 +43422,7 @@ - gene_reaction_rule: "YER086W" - eccodes: "4.3.1.19" - subsystem: + - "Glycine, serine and threonine metabolism" - annotation: !!omap - bigg.reaction: "THRD_Lm" - kegg.pathway: @@ -42954,6 +43449,7 @@ - gene_reaction_rule: "YJR078W" - eccodes: "1.13.11.52" - subsystem: + - "Tryptophan metabolism" - annotation: !!omap - bigg.reaction: "TRPO2" - kegg.pathway: "sce00380" @@ -42975,6 +43471,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YDR403W" - subsystem: + - "Tryptophan metabolism" - annotation: !!omap - bigg.reaction: "TYRNFT" - metanetx.reaction: "MNXR104994" @@ -42995,6 +43492,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YOL151W" - subsystem: + - "Pyruvate metabolism" - annotation: !!omap - bigg.reaction: "LCADi" - kegg.reaction: "R01446" @@ -43014,6 +43512,7 @@ - gene_reaction_rule: "YML004C" - eccodes: "4.4.1.5" - subsystem: + - "Pyruvate metabolism" - annotation: !!omap - bigg.reaction: "LGTHL" - kegg.pathway: "sce00620" @@ -43032,6 +43531,7 @@ - gene_reaction_rule: "YHR072W" - eccodes: "5.4.99.7" - subsystem: + - "Steroid biosynthesis" - annotation: !!omap - bigg.reaction: "LNSTLS" - kegg.pathway: @@ -43055,6 +43555,7 @@ - gene_reaction_rule: "YJR148W" - eccodes: "2.6.1.42" - subsystem: + - "Valine, leucine and isoleucine metabolism" - annotation: !!omap - bigg.reaction: "LEUTA" - kegg.pathway: @@ -43084,6 +43585,7 @@ - gene_reaction_rule: "YHR208W" - eccodes: "2.6.1.42" - subsystem: + - "Valine, leucine and isoleucine metabolism" - annotation: !!omap - bigg.reaction: "LEUTAm" - kegg.pathway: @@ -43115,6 +43617,7 @@ - gene_reaction_rule: "YPL160W" - eccodes: "6.1.1.4" - subsystem: + - "tRNA metabolism" - annotation: !!omap - bigg.reaction: "LEUTRS" - kegg.pathway: "sce00970" @@ -43138,6 +43641,7 @@ - gene_reaction_rule: "YLR382C" - eccodes: "6.1.1.4" - subsystem: + - "tRNA metabolism" - annotation: !!omap - bigg.reaction: "LEUTRSm" - kegg.pathway: "sce00970" @@ -43158,6 +43662,7 @@ - gene_reaction_rule: "YNL045W" - eccodes: "3.3.2.6" - subsystem: + - "Arachidonic acid metabolism" - annotation: !!omap - pubmed: "11601994" - sbo: "SBO:0000176" @@ -43174,6 +43679,7 @@ - gene_reaction_rule: "YNL045W" - eccodes: "3.3.2.6" - subsystem: + - "Arachidonic acid metabolism" - annotation: !!omap - pubmed: "11601994" - sbo: "SBO:0000176" @@ -43190,6 +43696,7 @@ - gene_reaction_rule: "YNL045W" - eccodes: "3.3.2.6" - subsystem: + - "Arachidonic acid metabolism" - annotation: !!omap - pubmed: "11601994" - sbo: "SBO:0000176" @@ -43206,6 +43713,7 @@ - gene_reaction_rule: "YNL045W" - eccodes: "3.3.2.6" - subsystem: + - "Arachidonic acid metabolism" - annotation: !!omap - pubmed: "11601994" - sbo: "SBO:0000176" @@ -43222,6 +43730,7 @@ - gene_reaction_rule: "YNL045W" - eccodes: "3.3.2.6" - subsystem: + - "Arachidonic acid metabolism" - annotation: !!omap - bigg.reaction: "LTA4H" - kegg.reaction: "R03057" @@ -43241,6 +43750,7 @@ - gene_reaction_rule: "YNL045W" - eccodes: "3.3.2.6" - subsystem: + - "Arachidonic acid metabolism" - annotation: !!omap - kegg.reaction: "R03057" - metanetx.reaction: "MNXR107919" @@ -43262,6 +43772,7 @@ - gene_reaction_rule: "YDR037W" - eccodes: "6.1.1.6" - subsystem: + - "tRNA metabolism" - annotation: !!omap - bigg.reaction: "LYSTRS" - kegg.pathway: "sce00970" @@ -43285,6 +43796,7 @@ - gene_reaction_rule: "YNL073W" - eccodes: "6.1.1.6" - subsystem: + - "tRNA metabolism" - annotation: !!omap - bigg.reaction: "LYSTRSm" - kegg.pathway: "sce00970" @@ -43307,6 +43819,7 @@ - gene_reaction_rule: "YKL085W" - eccodes: "1.1.1.37" - subsystem: + - "Citrate cycle (TCA cycle)" - annotation: !!omap - bigg.reaction: "MDHm" - kegg.pathway: @@ -43336,6 +43849,7 @@ - gene_reaction_rule: "YOL126C" - eccodes: "1.1.1.37" - subsystem: + - "Citrate cycle (TCA cycle)" - annotation: !!omap - bigg.reaction: "MDH" - kegg.pathway: @@ -43365,6 +43879,7 @@ - gene_reaction_rule: "YDL078C" - eccodes: "1.1.1.37" - subsystem: + - "Citrate cycle (TCA cycle)" - annotation: !!omap - bigg.reaction: "MDHp" - kegg.pathway: @@ -43395,6 +43910,7 @@ - gene_reaction_rule: "YIR031C or YNL117W" - eccodes: "2.3.3.9" - subsystem: + - "Pyruvate metabolism" - annotation: !!omap - bigg.reaction: "MALS" - kegg.pathway: @@ -43421,6 +43937,7 @@ - gene_reaction_rule: "YNL117W" - eccodes: "2.3.3.9" - subsystem: + - "Pyruvate metabolism" - annotation: !!omap - bigg.reaction: "MALSp" - kegg.pathway: @@ -43447,6 +43964,7 @@ - gene_reaction_rule: "YKL029C" - eccodes: "1.1.1.38" - subsystem: + - "Pyruvate metabolism" - annotation: !!omap - bigg.reaction: "ME1m" - kegg.pathway: @@ -43474,6 +43992,7 @@ - gene_reaction_rule: "YKL029C" - eccodes: "1.1.1.38" - subsystem: + - "Pyruvate metabolism" - annotation: !!omap - bigg.reaction: "ME2m" - kegg.pathway: @@ -43500,6 +44019,7 @@ - gene_reaction_rule: "YKL192C and YOR221C" - eccodes: "2.3.1.39" - subsystem: + - "Fatty acid biosynthesis" - annotation: !!omap - bigg.reaction: "MCOATAm" - kegg.pathway: @@ -43526,6 +44046,7 @@ - gene_reaction_rule: "YDL055C" - eccodes: "2.7.7.13" - subsystem: + - "Fructose and mannose metabolism" - annotation: !!omap - bigg.reaction: "MAN1PT" - kegg.pathway: @@ -43547,6 +44068,7 @@ - gene_reaction_rule: "YER003C" - eccodes: "5.3.1.8" - subsystem: + - "Fructose and mannose metabolism" - annotation: !!omap - bigg.reaction: "MAN6PI" - kegg.pathway: @@ -43574,6 +44096,7 @@ - "3.5.4.9" - "6.3.4.3" - subsystem: + - "One carbon pool by folate" - annotation: !!omap - bigg.reaction: "MTHFCm" - kegg.pathway: "sce00670" @@ -43597,6 +44120,7 @@ - "3.5.4.9" - "6.3.4.3" - subsystem: + - "One carbon pool by folate" - annotation: !!omap - bigg.reaction: "MTHFC" - kegg.pathway: "sce00670" @@ -43619,6 +44143,7 @@ - gene_reaction_rule: "YDR502C or YLR180W" - eccodes: "2.5.1.6" - subsystem: + - "Cysteine and methionine metabolism" - annotation: !!omap - bigg.reaction: "METAT" - kegg.pathway: @@ -43643,6 +44168,7 @@ - gene_reaction_rule: "YER091C" - eccodes: "2.1.1.14" - subsystem: + - "Cysteine and methionine metabolism" - annotation: !!omap - bigg.reaction: "METS" - kegg.pathway: @@ -43669,6 +44195,7 @@ - gene_reaction_rule: "YBL013W" - eccodes: "2.1.2.9" - subsystem: + - "tRNA metabolism" - annotation: !!omap - bigg.reaction: "FMETTRSm" - kegg.pathway: @@ -43693,6 +44220,7 @@ - gene_reaction_rule: "YGR264C" - eccodes: "6.1.1.10" - subsystem: + - "tRNA metabolism" - annotation: !!omap - bigg.reaction: "METTRS" - kegg.pathway: @@ -43718,6 +44246,7 @@ - gene_reaction_rule: "YGR171C" - eccodes: "6.1.1.10" - subsystem: + - "tRNA metabolism" - annotation: !!omap - bigg.reaction: "METTRSm" - kegg.pathway: @@ -43741,6 +44270,7 @@ - gene_reaction_rule: "YKR080W" - eccodes: "1.5.1.15" - subsystem: + - "One carbon pool by folate" - annotation: !!omap - bigg.reaction: "MTHFD2i" - kegg.pathway: "sce00670" @@ -43764,6 +44294,7 @@ - "3.5.4.9" - "6.3.4.3" - subsystem: + - "One carbon pool by folate" - annotation: !!omap - bigg.reaction: "MTHFD" - kegg.pathway: "sce00670" @@ -43787,6 +44318,7 @@ - "3.5.4.9" - "6.3.4.3" - subsystem: + - "One carbon pool by folate" - annotation: !!omap - bigg.reaction: "MTHFDm" - kegg.pathway: "sce00670" @@ -43810,6 +44342,7 @@ - gene_reaction_rule: "YPR006C" - eccodes: "4.1.3.30" - subsystem: + - "Propanoate metabolism" - annotation: !!omap - bigg.reaction: "MCITL2m" - kegg.pathway: @@ -43835,6 +44368,7 @@ - gene_reaction_rule: "YMR208W" - eccodes: "2.7.1.36" - subsystem: + - "Terpenoid backbone biosynthesis" - annotation: !!omap - bigg.reaction: "MEVK1" - kegg.pathway: @@ -43860,6 +44394,7 @@ - gene_reaction_rule: "YMR208W" - eccodes: "2.7.1.36" - subsystem: + - "Terpenoid backbone biosynthesis" - annotation: !!omap - bigg.reaction: "MEVK2" - kegg.pathway: @@ -43884,6 +44419,7 @@ - gene_reaction_rule: "YMR208W" - eccodes: "2.7.1.36" - subsystem: + - "Terpenoid backbone biosynthesis" - annotation: !!omap - bigg.reaction: "MEVK3" - kegg.pathway: @@ -43908,6 +44444,7 @@ - gene_reaction_rule: "YMR208W" - eccodes: "2.7.1.36" - subsystem: + - "Terpenoid backbone biosynthesis" - annotation: !!omap - bigg.reaction: "MEVK4" - kegg.pathway: @@ -43933,6 +44470,7 @@ - gene_reaction_rule: "YNR043W" - eccodes: "4.1.1.33" - subsystem: + - "Terpenoid backbone biosynthesis" - annotation: !!omap - bigg.reaction: "DPMVD" - kegg.pathway: @@ -43959,6 +44497,7 @@ - "2.-.-.-" - "2.4.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - metanetx.reaction: "MNXR126697" - pubmed: @@ -43982,6 +44521,7 @@ - "2.-.-.-" - "2.4.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "12954640" @@ -44004,6 +44544,7 @@ - "2.-.-.-" - "2.4.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "12954640" @@ -44026,6 +44567,7 @@ - "2.-.-.-" - "2.4.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "12954640" @@ -44048,6 +44590,7 @@ - "2.-.-.-" - "2.4.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "12954640" @@ -44070,6 +44613,7 @@ - "2.-.-.-" - "2.4.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "12954640" @@ -44092,6 +44636,7 @@ - "2.-.-.-" - "2.4.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "12954640" @@ -44114,6 +44659,7 @@ - "2.-.-.-" - "2.4.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "12954640" @@ -44136,6 +44682,7 @@ - "2.-.-.-" - "2.4.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "12954640" @@ -44158,6 +44705,7 @@ - "2.-.-.-" - "2.4.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "12954640" @@ -44177,6 +44725,7 @@ - gene_reaction_rule: "YDR287W or YHR046C" - eccodes: "3.1.3.25" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - bigg.reaction: "MI1PP" - kegg.pathway: @@ -44198,6 +44747,7 @@ - gene_reaction_rule: "YJL153C" - eccodes: "5.5.1.4" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - bigg.reaction: "MI1PS" - kegg.pathway: @@ -44223,6 +44773,7 @@ - "1.2.1.38" - "2.7.2.8" - subsystem: + - "Arginine biosynthesis" - annotation: !!omap - bigg.reaction: "AGPRim" - kegg.pathway: @@ -44249,6 +44800,7 @@ - gene_reaction_rule: "YFL017C" - eccodes: "2.3.1.4" - subsystem: + - "Amino sugar and nucleotide sugar metabolism" - annotation: !!omap - bigg.reaction: "ACGAM6PS" - kegg.pathway: "sce00520" @@ -44273,6 +44825,7 @@ - "2.3.1.1" - "2.3.1.35" - subsystem: + - "Arginine biosynthesis" - annotation: !!omap - bigg.reaction: "ACGSm" - kegg.pathway: @@ -44299,6 +44852,7 @@ - gene_reaction_rule: "YDR428C" - eccodes: "3.5.1.9" - subsystem: + - "Tryptophan metabolism" - annotation: !!omap - bigg.reaction: "FKYNH" - kegg.pathway: @@ -44323,6 +44877,7 @@ - gene_reaction_rule: "YDR402C and YDR403W" - eccodes: "1.14.14.-" - subsystem: + - "Tryptophan metabolism" - annotation: !!omap - kegg.pathway: - "sce00071" @@ -44345,6 +44900,7 @@ - gene_reaction_rule: "YGL067W" - eccodes: "3.6.1.22" - subsystem: + - "Nicotinate and nicotinamide metabolism" - annotation: !!omap - bigg.reaction: "NADDPp" - kegg.pathway: @@ -44370,6 +44926,7 @@ - "2.7.1.23" - "2.7.1.86" - subsystem: + - "Nicotinate and nicotinamide metabolism" - annotation: !!omap - bigg.reaction: "NADK" - kegg.pathway: "sce00760" @@ -44394,6 +44951,7 @@ - "2.7.1.23" - "2.7.1.86" - subsystem: + - "Nicotinate and nicotinamide metabolism" - annotation: !!omap - bigg.reaction: "NADKm" - kegg.pathway: "sce00760" @@ -44416,6 +44974,7 @@ - gene_reaction_rule: "YDL042C or YDR191W or YOL068C or YOR025W or YPL015C" - eccodes: "3.5.1.-" - subsystem: + - "Nicotinate and nicotinamide metabolism" - annotation: !!omap - kegg.pathway: - "sce00760" @@ -44443,6 +45002,7 @@ - gene_reaction_rule: "YHR074W" - eccodes: "6.3.5.1" - subsystem: + - "Nicotinate and nicotinamide metabolism" - annotation: !!omap - bigg.reaction: "NADS2" - kegg.pathway: "sce00760" @@ -44469,6 +45029,7 @@ - gene_reaction_rule: "YHR074W" - eccodes: "6.3.5.1" - subsystem: + - "Nicotinate and nicotinamide metabolism" - annotation: !!omap - kegg.pathway: "sce00760" - kegg.reaction: "R00257" @@ -44490,6 +45051,7 @@ - gene_reaction_rule: "YDL085W or YMR145C" - eccodes: "1.6.5.9" - subsystem: + - "Oxidative phosphorylation" - annotation: !!omap - bigg.reaction: "NADH2_u6cm" - metanetx.reaction: "MNXR101868" @@ -44512,6 +45074,7 @@ - "2.7.1.23" - "2.7.1.86" - subsystem: + - "Nicotinate and nicotinamide metabolism" - annotation: !!omap - kegg.pathway: "sce00760" - kegg.reaction: "R00105" @@ -44535,6 +45098,7 @@ - "2.7.1.23" - "2.7.1.86" - subsystem: + - "Nicotinate and nicotinamide metabolism" - annotation: !!omap - kegg.pathway: "sce00760" - kegg.reaction: "R00105" @@ -44556,6 +45120,7 @@ - gene_reaction_rule: "YML120C" - eccodes: "1.6.5.9" - subsystem: + - "Oxidative phosphorylation" - annotation: !!omap - bigg.reaction: "NADH2_u6m" - metanetx.reaction: "MNXR101869" @@ -44578,6 +45143,7 @@ - gene_reaction_rule: "YOR209C" - eccodes: "6.3.4.21" - subsystem: + - "Nicotinate and nicotinamide metabolism" - annotation: !!omap - bigg.reaction: "NAPRT" - kegg.pathway: "sce00760" @@ -44602,6 +45168,7 @@ - gene_reaction_rule: "YOR209C" - eccodes: "6.3.4.21" - subsystem: + - "Nicotinate and nicotinamide metabolism" - annotation: !!omap - bigg.reaction: "NAPRTm" - kegg.pathway: "sce00760" @@ -44622,6 +45189,7 @@ - gene_reaction_rule: "YGL037C" - eccodes: "3.5.1.19" - subsystem: + - "Nicotinate and nicotinamide metabolism" - annotation: !!omap - bigg.reaction: "NNAM" - kegg.pathway: @@ -44644,6 +45212,7 @@ - gene_reaction_rule: "YLR285W" - eccodes: "2.1.1.-" - subsystem: + - "Nicotinate and nicotinamide metabolism" - annotation: !!omap - bigg.reaction: "NNMT" - kegg.reaction: "R01269" @@ -44667,6 +45236,7 @@ - "2.7.7.1" - "2.7.7.18" - subsystem: + - "Nicotinate and nicotinamide metabolism" - annotation: !!omap - bigg.reaction: "NMNAT" - kegg.pathway: "sce00760" @@ -44691,6 +45261,7 @@ - "2.7.7.1" - "2.7.7.18" - subsystem: + - "Nicotinate and nicotinamide metabolism" - annotation: !!omap - bigg.reaction: "NMNATn" - kegg.pathway: "sce00760" @@ -44715,6 +45286,7 @@ - "2.7.7.1" - "2.7.7.18" - subsystem: + - "Nicotinate and nicotinamide metabolism" - annotation: !!omap - bigg.reaction: "NNATr" - kegg.pathway: "sce00760" @@ -44738,6 +45310,7 @@ - gene_reaction_rule: "YFR047C" - eccodes: "2.4.2.19" - subsystem: + - "Nicotinate and nicotinamide metabolism" - annotation: !!omap - bigg.reaction: "NNDPR" - kegg.pathway: "sce00760" @@ -44760,6 +45333,7 @@ - gene_reaction_rule: "YFR047C" - eccodes: "2.4.2.19" - subsystem: + - "Nicotinate and nicotinamide metabolism" - annotation: !!omap - bigg.reaction: "NNDPRm" - kegg.pathway: "sce00760" @@ -44781,6 +45355,7 @@ - gene_reaction_rule: "YER005W" - eccodes: "3.6.1.5" - subsystem: + - "Purine metabolism" - annotation: !!omap - bigg.reaction: "NDP1" - kegg.pathway: @@ -44805,6 +45380,7 @@ - gene_reaction_rule: "YER005W" - eccodes: "3.6.1.5" - subsystem: + - "Purine metabolism" - annotation: !!omap - bigg.reaction: "NDP3" - kegg.pathway: @@ -44829,6 +45405,7 @@ - gene_reaction_rule: "YER005W" - eccodes: "3.6.1.5" - subsystem: + - "Pyrimidine metabolism" - annotation: !!omap - bigg.reaction: "NDP7" - kegg.pathway: @@ -44853,6 +45430,7 @@ - gene_reaction_rule: "YEL042W" - eccodes: "3.6.1.42" - subsystem: + - "Pyrimidine metabolism" - annotation: !!omap - bigg.reaction: "NDP7g" - kegg.reaction: "R00155" @@ -44873,6 +45451,7 @@ - gene_reaction_rule: "YER005W" - eccodes: "3.6.1.5" - subsystem: + - "Pyrimidine metabolism" - annotation: !!omap - bigg.reaction: "CDPPH" - kegg.pathway: @@ -44896,6 +45475,7 @@ - gene_reaction_rule: "YER005W" - eccodes: "3.6.1.5" - subsystem: + - "Purine metabolism" - annotation: !!omap - bigg.reaction: "IDPA" - kegg.pathway: @@ -44918,6 +45498,7 @@ - gene_reaction_rule: "YKL067W" - eccodes: "2.7.4.6" - subsystem: + - "Pyrimidine metabolism" - annotation: !!omap - bigg.reaction: "NDPK3" - kegg.pathway: @@ -44942,6 +45523,7 @@ - gene_reaction_rule: "YKL067W" - eccodes: "2.7.4.6" - subsystem: + - "Purine metabolism" - annotation: !!omap - bigg.reaction: "NDPK8" - kegg.pathway: @@ -44966,6 +45548,7 @@ - gene_reaction_rule: "YKL067W" - eccodes: "2.7.4.6" - subsystem: + - "Pyrimidine metabolism" - annotation: !!omap - bigg.reaction: "NDPK7" - kegg.pathway: @@ -44990,6 +45573,7 @@ - gene_reaction_rule: "YKL067W" - eccodes: "2.7.4.6" - subsystem: + - "Purine metabolism" - annotation: !!omap - bigg.reaction: "NDPK5" - kegg.pathway: @@ -45014,6 +45598,7 @@ - gene_reaction_rule: "YKL067W" - eccodes: "2.7.4.6" - subsystem: + - "Pyrimidine metabolism" - annotation: !!omap - bigg.reaction: "NDPK4" - kegg.pathway: @@ -45038,6 +45623,7 @@ - gene_reaction_rule: "YKL067W" - eccodes: "2.7.4.6" - subsystem: + - "Purine metabolism" - annotation: !!omap - bigg.reaction: "NDPK1" - kegg.pathway: @@ -45062,6 +45648,7 @@ - gene_reaction_rule: "YKL067W" - eccodes: "2.7.4.6" - subsystem: + - "Purine metabolism" - annotation: !!omap - bigg.reaction: "NDPK9" - kegg.pathway: @@ -45086,6 +45673,7 @@ - gene_reaction_rule: "YKL067W" - eccodes: "2.7.4.6" - subsystem: + - "Purine metabolism" - annotation: !!omap - bigg.reaction: "NDPK10" - kegg.pathway: @@ -45110,6 +45698,7 @@ - gene_reaction_rule: "YKL067W" - eccodes: "2.7.4.6" - subsystem: + - "Pyrimidine metabolism" - annotation: !!omap - bigg.reaction: "NDPK6" - kegg.pathway: @@ -45135,6 +45724,7 @@ - gene_reaction_rule: "YAL035W or YLL001W or YER005W" - eccodes: "3.6.1.5" - subsystem: + - "Purine metabolism" - annotation: !!omap - bigg.reaction: "NTP3" - kegg.pathway: @@ -45159,6 +45749,7 @@ - gene_reaction_rule: "YER005W" - eccodes: "3.6.1.5" - subsystem: + - "Pyrimidine metabolism" - annotation: !!omap - bigg.reaction: "NTP7" - kegg.pathway: @@ -45183,6 +45774,7 @@ - gene_reaction_rule: "YER005W" - eccodes: "3.6.1.5" - subsystem: + - "Pyrimidine metabolism" - annotation: !!omap - bigg.reaction: "NTP5" - kegg.pathway: @@ -45206,6 +45798,7 @@ - gene_reaction_rule: "YER005W" - eccodes: "3.6.1.5" - subsystem: + - "Purine metabolism" - annotation: !!omap - bigg.reaction: "NTP10" - kegg.pathway: @@ -45229,6 +45822,7 @@ - gene_reaction_rule: "YEL042W" - eccodes: "3.6.1.42" - subsystem: + - "Purine metabolism" - annotation: !!omap - bigg.reaction: "NDP3g" - kegg.reaction: "R00328" @@ -45248,6 +45842,7 @@ - gene_reaction_rule: "YKL067W" - eccodes: "2.7.4.6" - subsystem: + - "Pyrimidine metabolism" - annotation: !!omap - bigg.reaction: "NDPK2" - kegg.pathway: @@ -45275,6 +45870,7 @@ - "2.5.1.47" - "2.5.1.49" - subsystem: + - "Cysteine and methionine metabolism" - annotation: !!omap - bigg.reaction: "AHSERL" - kegg.pathway: @@ -45304,6 +45900,7 @@ - "2.5.1.47" - "2.5.1.49" - subsystem: + - "Cysteine and methionine metabolism" - annotation: !!omap - bigg.reaction: "AHSERL2" - kegg.pathway: @@ -45332,6 +45929,7 @@ - gene_reaction_rule: "YLL058W or YML082W or YAL012W" - eccodes: "4.4.1.1" - subsystem: + - "Cysteine and methionine metabolism" - annotation: !!omap - bigg.reaction: "SHSL1" - kegg.pathway: @@ -45359,6 +45957,7 @@ - gene_reaction_rule: "YJL088W" - eccodes: "2.1.3.3" - subsystem: + - "Arginine biosynthesis" - annotation: !!omap - bigg.reaction: "OCBT" - kegg.pathway: @@ -45383,6 +45982,7 @@ - gene_reaction_rule: "YKL184W" - eccodes: "4.1.1.17" - subsystem: + - "Arginine and proline metabolism" - annotation: !!omap - bigg.reaction: "ORNDC" - kegg.pathway: @@ -45409,6 +46009,7 @@ - "2.3.1.1" - "2.3.1.35" - subsystem: + - "Arginine biosynthesis" - annotation: !!omap - bigg.reaction: "ORNTACim" - kegg.pathway: @@ -45434,6 +46035,7 @@ - gene_reaction_rule: "YLR438W" - eccodes: "2.6.1.13" - subsystem: + - "Arginine and proline metabolism" - annotation: !!omap - bigg.reaction: "ORNTA" - kegg.pathway: @@ -45457,6 +46059,7 @@ - gene_reaction_rule: "YML106W or YMR271C" - eccodes: "2.4.2.10" - subsystem: + - "Pyrimidine metabolism" - annotation: !!omap - bigg.reaction: "ORPT" - kegg.pathway: "sce00240" @@ -45477,6 +46080,7 @@ - gene_reaction_rule: "YEL021W" - eccodes: "4.1.1.23" - subsystem: + - "Pyrimidine metabolism" - annotation: !!omap - bigg.reaction: "OMPDC" - kegg.pathway: "sce00240" @@ -45494,12 +46098,13 @@ - s_1464: 1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "YDR148C and YFL018C and YIL125W" + - gene_reaction_rule: "(YDR148C and YFL018C and YIL125W and YFR049W) or (YDR148C and YFL018C and YIL125W)" - eccodes: - "1.2.4.2" - "1.8.1.4" - "2.3.1.61" - subsystem: + - "Citrate cycle (TCA cycle)" - annotation: !!omap - bigg.reaction: "AKGDbm" - kegg.pathway: @@ -45531,12 +46136,13 @@ - s_1411: 1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "YDR148C and YFL018C and YIL125W" + - gene_reaction_rule: "(YDR148C and YFL018C and YIL125W and YFR049W) or (YDR148C and YFL018C and YIL125W)" - eccodes: - "1.2.4.2" - "1.8.1.4" - "2.3.1.61" - subsystem: + - "Citrate cycle (TCA cycle)" - annotation: !!omap - bigg.reaction: "AKGDam" - kegg.pathway: @@ -45571,6 +46177,7 @@ - gene_reaction_rule: "YGR277C" - eccodes: "2.7.7.3" - subsystem: + - "Pantothenate and coa biosynthesis" - annotation: !!omap - bigg.reaction: "PTPATi" - kegg.pathway: "sce00770" @@ -45593,6 +46200,7 @@ - gene_reaction_rule: "YDR531W" - eccodes: "2.7.1.33" - subsystem: + - "Pantothenate and coa biosynthesis" - annotation: !!omap - bigg.reaction: "PNTK" - kegg.pathway: "sce00770" @@ -45616,6 +46224,7 @@ - gene_reaction_rule: "YIL145C" - eccodes: "6.3.2.1" - subsystem: + - "Pantothenate and coa biosynthesis" - annotation: !!omap - bigg.reaction: "PANTS" - kegg.pathway: @@ -45640,6 +46249,7 @@ - gene_reaction_rule: "YJR019C" - eccodes: "3.1.2.2" - subsystem: + - "Biosynthesis of unsaturated fatty acids" - annotation: !!omap - kegg.pathway: - "sce00062" @@ -45663,6 +46273,7 @@ - gene_reaction_rule: "YJR019C" - eccodes: "3.1.2.2" - subsystem: + - "Biosynthesis of unsaturated fatty acids" - annotation: !!omap - bigg.reaction: "PTE11x" - kegg.pathway: @@ -45687,6 +46298,7 @@ - gene_reaction_rule: "YJR019C" - eccodes: "3.1.2.2" - subsystem: + - "Biosynthesis of unsaturated fatty acids" - annotation: !!omap - bigg.reaction: "PTE2x" - kegg.pathway: @@ -45712,6 +46324,7 @@ - gene_reaction_rule: "YJR019C" - eccodes: "3.1.2.2" - subsystem: + - "Biosynthesis of unsaturated fatty acids" - annotation: !!omap - bigg.reaction: "PTE7x" - kegg.pathway: @@ -45736,6 +46349,7 @@ - gene_reaction_rule: "YJR019C" - eccodes: "3.1.2.2" - subsystem: + - "Biosynthesis of unsaturated fatty acids" - annotation: !!omap - bigg.reaction: "PTE8x" - kegg.pathway: @@ -45761,6 +46375,7 @@ - gene_reaction_rule: "YJR019C" - eccodes: "3.1.2.2" - subsystem: + - "Biosynthesis of unsaturated fatty acids" - annotation: !!omap - bigg.reaction: "PTE9x" - kegg.pathway: @@ -45786,6 +46401,7 @@ - "2.6.1.39" - "2.6.1.57" - subsystem: + - "Phenylalanine, tyrosine and tryptophan biosynthesis" - annotation: !!omap - bigg.reaction: "PHETA1" - kegg.pathway: @@ -45822,6 +46438,7 @@ - gene_reaction_rule: "YFL022C and YLR060W" - eccodes: "6.1.1.20" - subsystem: + - "tRNA metabolism" - annotation: !!omap - bigg.reaction: "PHETRS" - kegg.pathway: "sce00970" @@ -45845,6 +46462,7 @@ - gene_reaction_rule: "YPR047W" - eccodes: "6.1.1.20" - subsystem: + - "tRNA metabolism" - annotation: !!omap - bigg.reaction: "PHETRSm" - kegg.pathway: "sce00970" @@ -45866,6 +46484,7 @@ - gene_reaction_rule: "YDR380W" - eccodes: "4.1.1.43" - subsystem: + - "Phenylalanine metabolism" - annotation: !!omap - bigg.reaction: "PPYRDC" - kegg.pathway: "sce00360" @@ -45891,6 +46510,7 @@ - "6.3.3.1" - "6.3.4.13" - subsystem: + - "Purine metabolism" - annotation: !!omap - bigg.reaction: "PRAIS" - kegg.pathway: @@ -45912,6 +46532,7 @@ - gene_reaction_rule: "YEL058W" - eccodes: "5.4.2.3" - subsystem: + - "Amino sugar and nucleotide sugar metabolism" - annotation: !!omap - kegg.pathway: - "sce00520" @@ -45936,6 +46557,7 @@ - gene_reaction_rule: "(YGR209C and YPR167C) or (YLR043C and YPR167C)" - eccodes: "1.8.4.8" - subsystem: + - "Sulfur metabolism" - annotation: !!omap - bigg.reaction: "PAPSR" - kegg.pathway: "sce00920" @@ -45957,6 +46579,7 @@ - gene_reaction_rule: "YKR097W" - eccodes: "4.1.1.49" - subsystem: + - "Glycolysis / gluconeogenesis" - annotation: !!omap - bigg.reaction: "PPCK" - kegg.pathway: @@ -45984,6 +46607,7 @@ - gene_reaction_rule: "YGR007W" - eccodes: "2.7.7.14" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - bigg.reaction: "PETHCT" - kegg.pathway: @@ -46004,9 +46628,10 @@ - s_0794: 1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "YMR205C or (YGR240C and YMR205C)" + - gene_reaction_rule: "YGR240C and YMR205C" - eccodes: "2.7.1.11" - subsystem: + - "Glycolysis / gluconeogenesis" - annotation: !!omap - bigg.reaction: "PFK" - kegg.pathway: @@ -46035,9 +46660,10 @@ - s_1427: -1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "YMR205C or (YGR240C and YMR205C)" + - gene_reaction_rule: "YGR240C and YMR205C" - eccodes: "2.7.1.11" - subsystem: + - "Glycolysis / gluconeogenesis" - annotation: !!omap - bigg.reaction: "PFK_3" - kegg.pathway: @@ -46065,6 +46691,7 @@ - gene_reaction_rule: "YMR105C or YKL127W" - eccodes: "5.4.2.2" - subsystem: + - "Pentose phosphate pathway" - annotation: !!omap - bigg.reaction: "PGMT" - kegg.pathway: @@ -46097,6 +46724,7 @@ - gene_reaction_rule: "YGR256W or YHR183W" - eccodes: "1.1.1.44" - subsystem: + - "Pentose phosphate pathway" - annotation: !!omap - bigg.reaction: "GND" - kegg.pathway: @@ -46121,6 +46749,7 @@ - gene_reaction_rule: "YEL058W" - eccodes: "5.4.2.3" - subsystem: + - "Amino sugar and nucleotide sugar metabolism" - annotation: !!omap - bigg.reaction: "PGAMT" - kegg.pathway: @@ -46147,6 +46776,7 @@ - "1.1.1.399" - "1.1.1.95" - subsystem: + - "Glycine, serine and threonine metabolism" - annotation: !!omap - bigg.reaction: "PGCD" - kegg.pathway: @@ -46172,6 +46802,7 @@ - gene_reaction_rule: "YCR012W" - eccodes: "2.7.2.3" - subsystem: + - "Glycolysis / gluconeogenesis" - annotation: !!omap - bigg.reaction: "PGK" - kegg.pathway: @@ -46196,6 +46827,7 @@ - gene_reaction_rule: "YOR283W or YKL152C" - eccodes: "5.4.2.11" - subsystem: + - "Glycolysis / gluconeogenesis" - annotation: !!omap - bigg.reaction: "PGM" - kegg.pathway: @@ -46221,6 +46853,7 @@ - gene_reaction_rule: "YFL045C" - eccodes: "5.4.2.8" - subsystem: + - "Fructose and mannose metabolism" - annotation: !!omap - bigg.reaction: "PMANM" - kegg.pathway: @@ -46247,6 +46880,7 @@ - "2.7.1.49" - "2.7.4.7" - subsystem: + - "Thiamine metabolism" - annotation: !!omap - bigg.reaction: "PMPK" - kegg.pathway: "sce00730" @@ -46268,6 +46902,7 @@ - gene_reaction_rule: "YMR220W" - eccodes: "2.7.4.2" - subsystem: + - "Terpenoid backbone biosynthesis" - annotation: !!omap - bigg.reaction: "PMEVK" - kegg.pathway: @@ -46294,6 +46929,7 @@ - gene_reaction_rule: "YIL083C" - eccodes: "6.3.2.5" - subsystem: + - "Pantothenate and coa biosynthesis" - annotation: !!omap - bigg.reaction: "PPNCL2" - kegg.pathway: "sce00770" @@ -46311,9 +46947,10 @@ - s_1307: 1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "(YKL088W and YKR072C and YOR054C) or (YKL088W and YKR072C) or (YKL088W and YOR054C) or YKL088W" + - gene_reaction_rule: "YKL088W and YKR072C and YOR054C" - eccodes: "4.1.1.36" - subsystem: + - "Pantothenate and coa biosynthesis" - annotation: !!omap - bigg.reaction: "PPCDC" - kegg.pathway: "sce00770" @@ -46334,6 +46971,7 @@ - "5.4.2.2" - "5.4.2.7" - subsystem: + - "Pentose phosphate pathway" - annotation: !!omap - bigg.reaction: "PPM" - kegg.pathway: @@ -46364,6 +47002,7 @@ - gene_reaction_rule: "YAR015W" - eccodes: "6.3.2.6" - subsystem: + - "Purine metabolism" - annotation: !!omap - bigg.reaction: "PRASCSi" - kegg.pathway: @@ -46389,6 +47028,7 @@ - "3.5.4.19" - "3.6.1.31" - subsystem: + - "Histidine metabolism" - annotation: !!omap - bigg.reaction: "PRAMPC" - kegg.pathway: @@ -46417,6 +47057,7 @@ - "3.5.4.19" - "3.6.1.31" - subsystem: + - "Histidine metabolism" - annotation: !!omap - bigg.reaction: "PRATPP" - kegg.pathway: @@ -46440,6 +47081,7 @@ - gene_reaction_rule: "YOR128C" - eccodes: "4.1.1.21" - subsystem: + - "Purine metabolism" - annotation: !!omap - kegg.pathway: - "sce00230" @@ -46463,6 +47105,7 @@ - "2.1.2.3" - "3.5.4.10" - subsystem: + - "Purine metabolism" - annotation: !!omap - bigg.reaction: "AICART" - kegg.pathway: @@ -46485,6 +47128,7 @@ - gene_reaction_rule: "YDR007W" - eccodes: "5.3.1.24" - subsystem: + - "Phenylalanine, tyrosine and tryptophan biosynthesis" - annotation: !!omap - bigg.reaction: "PRAIi" - kegg.pathway: @@ -46515,6 +47159,7 @@ - "6.3.3.1" - "6.3.4.13" - subsystem: + - "Purine metabolism" - annotation: !!omap - bigg.reaction: "PRAGSr" - kegg.pathway: @@ -46540,6 +47185,7 @@ - gene_reaction_rule: "YMR300C" - eccodes: "2.4.2.14" - subsystem: + - "Purine metabolism" - annotation: !!omap - bigg.reaction: "GLUPRT" - kegg.pathway: @@ -46565,6 +47211,7 @@ - gene_reaction_rule: "(YKL181W and YER099C) or (YKL181W and YHL011C) or (YKL181W and YBL068W) or (YER099C and YOL061W) or (YBL068W and YOL061W)" - eccodes: "2.7.6.1" - subsystem: + - "Pentose phosphate pathway" - annotation: !!omap - bigg.reaction: "PRPPS" - kegg.pathway: @@ -46591,6 +47238,7 @@ - gene_reaction_rule: "YGR208W" - eccodes: "3.1.3.3" - subsystem: + - "Glycine, serine and threonine metabolism" - annotation: !!omap - bigg.reaction: "PSP_L" - kegg.pathway: @@ -46616,6 +47264,7 @@ - gene_reaction_rule: "YOR184W" - eccodes: "2.6.1.52" - subsystem: + - "Glycine, serine and threonine metabolism" - annotation: !!omap - bigg.reaction: "PSERT" - kegg.pathway: @@ -46642,6 +47291,7 @@ - gene_reaction_rule: "YBR183W" - eccodes: "3.5.1.-" - subsystem: + - "Sphingolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00600" - metanetx.reaction: "MNXR126696" @@ -46663,6 +47313,7 @@ - gene_reaction_rule: "YDR402C" - eccodes: "1.14.14.-" - subsystem: + - "Tryptophan metabolism" - annotation: !!omap - kegg.pathway: - "sce00071" @@ -46683,6 +47334,7 @@ - gene_reaction_rule: "YDR294C" - eccodes: "4.1.2.27" - subsystem: + - "Sphingolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00600" - metanetx.reaction: "MNXR103262" @@ -46707,6 +47359,7 @@ - gene_reaction_rule: "YDR297W" - eccodes: "1.-.-.-" - subsystem: + - "Sphingolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00600" - kegg.reaction: "R06525" @@ -46731,6 +47384,7 @@ - gene_reaction_rule: "YMR020W" - eccodes: "1.5.3.17" - subsystem: + - "Arginine and proline metabolism" - annotation: !!omap - bigg.reaction: "POLYAO" - kegg.pathway: @@ -46753,6 +47407,7 @@ - gene_reaction_rule: "YGL040C" - eccodes: "4.2.1.24" - subsystem: + - "Porphyrin and chlorophyll metabolism" - annotation: !!omap - bigg.reaction: "PPBNGS" - kegg.pathway: @@ -46777,6 +47432,7 @@ - gene_reaction_rule: "YMR020W" - eccodes: "1.5.3.17" - subsystem: + - "Arginine and proline metabolism" - annotation: !!omap - bigg.reaction: "POLYAO2" - kegg.pathway: @@ -46802,6 +47458,7 @@ - gene_reaction_rule: "YMR020W" - eccodes: "1.5.3.17" - subsystem: + - "Arginine and proline metabolism" - annotation: !!omap - bigg.reaction: "POLYAO3" - kegg.pathway: @@ -46826,6 +47483,7 @@ - gene_reaction_rule: "YNL316C" - eccodes: "4.2.1.51" - subsystem: + - "Phenylalanine, tyrosine and tryptophan biosynthesis" - annotation: !!omap - bigg.reaction: "PPNDH" - kegg.pathway: @@ -46852,6 +47510,7 @@ - gene_reaction_rule: "YBR166C" - eccodes: "1.3.1.13" - subsystem: + - "Phenylalanine, tyrosine and tryptophan biosynthesis" - annotation: !!omap - bigg.reaction: "PPND2" - kegg.pathway: @@ -46876,6 +47535,7 @@ - gene_reaction_rule: "YLR142W" - eccodes: "1.5.5.2" - subsystem: + - "Arginine and proline metabolism" - annotation: !!omap - kegg.pathway: - "sce00330" @@ -46900,6 +47560,7 @@ - gene_reaction_rule: "YHR020W" - eccodes: "6.1.1.15" - subsystem: + - "tRNA metabolism" - annotation: !!omap - bigg.reaction: "PROTRS_1" - kegg.pathway: "sce00970" @@ -46920,6 +47581,7 @@ - gene_reaction_rule: "YER014W" - eccodes: "1.3.3.4" - subsystem: + - "Porphyrin and chlorophyll metabolism" - annotation: !!omap - bigg.reaction: "PPPGOm" - kegg.pathway: @@ -46940,12 +47602,13 @@ - s_1322: -1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "YDR400W and YLR017W and YLR209C" + - gene_reaction_rule: "YLR209C" - eccodes: - "2.4.2.1" - "2.4.2.28" - "3.2.2.3" - subsystem: + - "Nicotinate and nicotinamide metabolism" - annotation: !!omap - bigg.reaction: "PNP" - kegg.pathway: @@ -46972,6 +47635,7 @@ - gene_reaction_rule: "YLR209C" - eccodes: "2.4.2.1" - subsystem: + - "Purine metabolism" - annotation: !!omap - bigg.reaction: "PUNP3" - kegg.pathway: @@ -46997,6 +47661,7 @@ - gene_reaction_rule: "YLR209C" - eccodes: "2.4.2.1" - subsystem: + - "Purine metabolism" - annotation: !!omap - bigg.reaction: "PUNP3m" - kegg.pathway: @@ -47022,6 +47687,7 @@ - gene_reaction_rule: "YLR209C" - eccodes: "2.4.2.1" - subsystem: + - "Purine metabolism" - annotation: !!omap - bigg.reaction: "PUNP5" - kegg.pathway: @@ -47049,6 +47715,7 @@ - gene_reaction_rule: "YBR035C" - eccodes: "1.4.3.5" - subsystem: + - "Vitamin b6 metabolism" - annotation: !!omap - bigg.reaction: "PYDXO" - kegg.pathway: "sce00750" @@ -47070,6 +47737,7 @@ - gene_reaction_rule: "YBR035C" - eccodes: "1.4.3.5" - subsystem: + - "Vitamin b6 metabolism" - annotation: !!omap - bigg.reaction: "PYAM5PO" - kegg.pathway: "sce00750" @@ -47090,6 +47758,7 @@ - gene_reaction_rule: "YBR035C" - eccodes: "1.4.3.5" - subsystem: + - "Vitamin b6 metabolism" - annotation: !!omap - bigg.reaction: "PDX5POi" - kegg.pathway: "sce00750" @@ -47110,6 +47779,7 @@ - gene_reaction_rule: "YBR035C" - eccodes: "1.4.3.5" - subsystem: + - "Vitamin b6 metabolism" - annotation: !!omap - bigg.reaction: "PYDXNO" - kegg.pathway: "sce00750" @@ -47131,6 +47801,7 @@ - gene_reaction_rule: "YER023W" - eccodes: "1.5.1.2" - subsystem: + - "Arginine and proline metabolism" - annotation: !!omap - bigg.reaction: "P5CR" - kegg.pathway: @@ -47158,6 +47829,7 @@ - gene_reaction_rule: "YBR218C or YGL062W" - eccodes: "6.4.1.1" - subsystem: + - "Pyruvate metabolism" - annotation: !!omap - bigg.reaction: "PC" - kegg.pathway: @@ -47186,6 +47858,7 @@ - "4.1.1.43" - "4.1.1.74" - subsystem: + - "Glycolysis / gluconeogenesis" - annotation: !!omap - bigg.reaction: "PYRDC" - kegg.pathway: @@ -47214,6 +47887,7 @@ - "4.1.1.43" - "4.1.1.74" - subsystem: + - "Glycolysis / gluconeogenesis" - annotation: !!omap - bigg.reaction: "PYRDC2" - kegg.pathway: @@ -47242,6 +47916,7 @@ - "1.8.1.4" - "2.3.1.12" - subsystem: + - "Glycolysis / gluconeogenesis" - annotation: !!omap - bigg.reaction: "PDHm" - kegg.pathway: @@ -47274,6 +47949,7 @@ - gene_reaction_rule: "YAL038W or YOR347C" - eccodes: "2.7.1.40" - subsystem: + - "Glycolysis / gluconeogenesis" - annotation: !!omap - bigg.reaction: "PYK" - kegg.pathway: @@ -47302,7 +47978,7 @@ - s_1278: -1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "YDR204W and YGL119W and YGR255C and YLR201C and YML110C and YOL096C and YOR125C" + - gene_reaction_rule: "YDR204W and YGR255C and YLR201C and YML110C and YOL096C and YOR125C" - eccodes: - "1.14.13.-" - "2.1.1.114" @@ -47310,6 +47986,7 @@ - "2.1.1.64" - "2.7.-.-" - subsystem: + - "Ubiquinone and other terpenoid-quinone biosynthesis" - annotation: !!omap - kegg.pathway: - "sce00130" @@ -47331,6 +48008,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YDR135C" - subsystem: + - "Transport [c, v]" - annotation: !!omap - metanetx.reaction: "MNXR100447" - pubmed: "9729482" @@ -47350,6 +48028,7 @@ - gene_reaction_rule: "YDR236C" - eccodes: "2.7.1.26" - subsystem: + - "Riboflavin metabolism" - annotation: !!omap - bigg.reaction: "RBFK" - kegg.pathway: @@ -47373,6 +48052,7 @@ - gene_reaction_rule: "YDR236C" - eccodes: "2.7.1.26" - subsystem: + - "Riboflavin metabolism" - annotation: !!omap - bigg.reaction: "RBFKm" - kegg.pathway: @@ -47397,6 +48077,7 @@ - gene_reaction_rule: "YOL143C" - eccodes: "2.5.1.78" - subsystem: + - "Riboflavin metabolism" - annotation: !!omap - bigg.reaction: "RBFSa" - kegg.pathway: @@ -47419,6 +48100,7 @@ - gene_reaction_rule: "YBR256C" - eccodes: "2.5.1.9" - subsystem: + - "Riboflavin metabolism" - annotation: !!omap - bigg.reaction: "RBFSb" - kegg.pathway: @@ -47442,6 +48124,7 @@ - gene_reaction_rule: "YCR036W" - eccodes: "2.7.1.15" - subsystem: + - "Pentose phosphate pathway" - annotation: !!omap - bigg.reaction: "RBK" - kegg.pathway: "sce00030" @@ -47464,6 +48147,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YGR209C" - subsystem: + - "Purine metabolism" - annotation: !!omap - bigg.reaction: "RNTR1" - kegg.reaction: "R02014" @@ -47484,6 +48168,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YGR209C" - subsystem: + - "Pyrimidine metabolism" - annotation: !!omap - bigg.reaction: "RNTR3" - kegg.reaction: "R02022" @@ -47504,6 +48189,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YGR209C" - subsystem: + - "Purine metabolism" - annotation: !!omap - bigg.reaction: "RNTR2" - kegg.reaction: "R02020" @@ -47524,6 +48210,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YGR209C" - subsystem: + - "Pyrimidine metabolism" - annotation: !!omap - bigg.reaction: "RNTR4" - kegg.reaction: "R02023" @@ -47545,6 +48232,7 @@ - gene_reaction_rule: "YER070W or YGR180C or YIL066C or YJL026W" - eccodes: "1.17.4.1" - subsystem: + - "Purine metabolism" - annotation: !!omap - bigg.reaction: "RNDR1" - kegg.pathway: @@ -47570,6 +48258,7 @@ - gene_reaction_rule: "YER070W or YGR180C or YIL066C or YJL026W" - eccodes: "1.17.4.1" - subsystem: + - "Purine metabolism" - annotation: !!omap - bigg.reaction: "RNDR1n" - kegg.pathway: @@ -47595,6 +48284,7 @@ - gene_reaction_rule: "YER070W or YGR180C or YIL066C or YJL026W" - eccodes: "1.17.4.1" - subsystem: + - "Pyrimidine metabolism" - annotation: !!omap - bigg.reaction: "RNDR3" - kegg.pathway: @@ -47620,6 +48310,7 @@ - gene_reaction_rule: "YER070W or YGR180C or YIL066C or YJL026W" - eccodes: "1.17.4.1" - subsystem: + - "Pyrimidine metabolism" - annotation: !!omap - bigg.reaction: "RNDR3n" - kegg.pathway: @@ -47645,6 +48336,7 @@ - gene_reaction_rule: "YER070W or YGR180C or YIL066C or YJL026W" - eccodes: "1.17.4.1" - subsystem: + - "Purine metabolism" - annotation: !!omap - bigg.reaction: "RNDR2" - kegg.pathway: @@ -47670,6 +48362,7 @@ - gene_reaction_rule: "YER070W or YGR180C or YIL066C or YJL026W" - eccodes: "1.17.4.1" - subsystem: + - "Purine metabolism" - annotation: !!omap - bigg.reaction: "RNDR2n" - kegg.pathway: @@ -47691,6 +48384,7 @@ - gene_reaction_rule: "YOR095C" - eccodes: "5.3.1.6" - subsystem: + - "Pentose phosphate pathway" - annotation: !!omap - bigg.reaction: "RPI" - kegg.pathway: @@ -47719,6 +48413,7 @@ - "2.7.1.173" - "2.7.1.22" - subsystem: + - "Nicotinate and nicotinamide metabolism" - annotation: !!omap - bigg.reaction: "RNMK" - kegg.pathway: "sce00760" @@ -47738,6 +48433,7 @@ - gene_reaction_rule: "YJL121C" - eccodes: "5.1.3.1" - subsystem: + - "Pentose phosphate pathway" - annotation: !!omap - bigg.reaction: "RPE" - kegg.pathway: @@ -47763,7 +48459,7 @@ - s_1419: -1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "YDR204W and YGL119W and YGR255C and YLR201C and YML110C and YOL096C and YOR125C" + - gene_reaction_rule: "YDR204W and YGR255C and YLR201C and YML110C and YOL096C and YOR125C" - eccodes: - "1.14.13.-" - "2.1.1.114" @@ -47771,6 +48467,7 @@ - "2.1.1.64" - "2.7.-.-" - subsystem: + - "Ubiquinone and other terpenoid-quinone biosynthesis" - annotation: !!omap - bigg.reaction: "3DH5HPBMTm" - kegg.pathway: @@ -47795,6 +48492,7 @@ - gene_reaction_rule: "YML008C" - eccodes: "2.1.1.41" - subsystem: + - "Steroid biosynthesis" - annotation: !!omap - bigg.reaction: "SAM24MT" - kegg.pathway: @@ -47819,6 +48517,7 @@ - gene_reaction_rule: "YJL068C" - eccodes: "3.1.2.12" - subsystem: + - "Alternate carbon metabolism" - annotation: !!omap - bigg.reaction: "SFGTHi" - kegg.pathway: "sce01200" @@ -47842,6 +48541,7 @@ - gene_reaction_rule: "YIR034C" - eccodes: "1.5.1.7" - subsystem: + - "Lysine metabolism" - annotation: !!omap - bigg.reaction: "SACCD2" - kegg.pathway: @@ -47871,6 +48571,7 @@ - gene_reaction_rule: "YNR050C" - eccodes: "1.5.1.10" - subsystem: + - "Lysine metabolism" - annotation: !!omap - bigg.reaction: "SACCD1" - kegg.pathway: @@ -47896,6 +48597,7 @@ - gene_reaction_rule: "YKL060C" - eccodes: "4.1.2.13" - subsystem: + - "Glycolysis / gluconeogenesis" - annotation: !!omap - bigg.reaction: "FBA3" - kegg.pathway: @@ -47920,8 +48622,9 @@ - s_1234: 1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "(YDL040C and YGR147C and YHR013C) or (YDL040C and YGR147C)" + - gene_reaction_rule: "YHR013C and YDL040C and YOR253W" - subsystem: + - "Cysteine and methionine metabolism" - annotation: !!omap - bigg.reaction: "SERAT" - kegg.reaction: "R00586" @@ -47941,9 +48644,10 @@ - s_1303: -1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "(YBR058C-A and YDR062W and YMR296C) or (YDR062W and YMR296C)" + - gene_reaction_rule: "YMR296C and YKL212W and YDR062W and YGR038W and YLR350W and YBR058C-A" - eccodes: "2.3.1.50" - subsystem: + - "Sphingolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00600" @@ -47972,6 +48676,7 @@ - gene_reaction_rule: "YDR023W or YHR011W" - eccodes: "6.1.1.11" - subsystem: + - "tRNA metabolism" - annotation: !!omap - bigg.reaction: "SERTRS" - kegg.pathway: "sce00970" @@ -47999,6 +48704,7 @@ - "4.2.1.10" - "4.2.3.4" - subsystem: + - "Phenylalanine, tyrosine and tryptophan biosynthesis" - annotation: !!omap - bigg.reaction: "SHK3Dr" - kegg.pathway: @@ -48030,6 +48736,7 @@ - "4.2.1.10" - "4.2.3.4" - subsystem: + - "Phenylalanine, tyrosine and tryptophan biosynthesis" - annotation: !!omap - bigg.reaction: "SHKK" - kegg.pathway: @@ -48058,6 +48765,7 @@ - "1.3.1.76" - "4.99.1.4" - subsystem: + - "Porphyrin and chlorophyll metabolism" - annotation: !!omap - bigg.reaction: "SHCHD2" - kegg.pathway: @@ -48083,6 +48791,7 @@ - "1.3.1.76" - "4.99.1.4" - subsystem: + - "Porphyrin and chlorophyll metabolism" - annotation: !!omap - bigg.reaction: "SHCHF" - kegg.pathway: @@ -48107,6 +48816,7 @@ - gene_reaction_rule: "YEL047C" - eccodes: "1.3.1.6" - subsystem: + - "Cellular response to anaerobic conditions" - annotation: !!omap - kegg.reaction: "R00408" - metanetx.reaction: "MNXR129857" @@ -48129,6 +48839,7 @@ - gene_reaction_rule: "YPR069C" - eccodes: "2.5.1.16" - subsystem: + - "Arginine and proline metabolism" - annotation: !!omap - bigg.reaction: "SPMS" - kegg.pathway: @@ -48154,6 +48865,7 @@ - gene_reaction_rule: "YLR146C" - eccodes: "2.5.1.22" - subsystem: + - "Arginine and proline metabolism" - annotation: !!omap - bigg.reaction: "SPRMS" - kegg.pathway: @@ -48177,6 +48889,7 @@ - gene_reaction_rule: "YDR294C" - eccodes: "4.1.2.27" - subsystem: + - "Sphingolipid metabolism" - annotation: !!omap - bigg.reaction: "SGPL11r" - kegg.pathway: "sce00600" @@ -48200,6 +48913,7 @@ - gene_reaction_rule: "YJL134W or YKR053C" - eccodes: "3.1.3.-" - subsystem: + - "Sphingolipid metabolism" - annotation: !!omap - bigg.reaction: "SBPP2er" - kegg.pathway: "sce00600" @@ -48223,6 +48937,7 @@ - gene_reaction_rule: "YJL134W or YKR053C" - eccodes: "3.1.3.-" - subsystem: + - "Sphingolipid metabolism" - annotation: !!omap - bigg.reaction: "SBPP1er" - kegg.pathway: "sce00600" @@ -48248,6 +48963,7 @@ - gene_reaction_rule: "YLR260W or YOR171C" - eccodes: "2.7.1.91" - subsystem: + - "Sphingolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00600" - metanetx.reaction: "MNXR104440" @@ -48270,6 +48986,7 @@ - gene_reaction_rule: "YLR260W or YOR171C" - eccodes: "2.7.1.91" - subsystem: + - "Sphingolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00600" - kegg.reaction: "R02976" @@ -48288,6 +49005,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "C5-branched dibasic acid metabolism" - annotation: !!omap - kegg.reaction: "R02244" - metanetx.reaction: "MNXR95382" @@ -48303,6 +49021,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "C5-branched dibasic acid metabolism" - annotation: !!omap - bigg.reaction: "ACONIs" - kegg.reaction: "R02244" @@ -48326,6 +49045,7 @@ - gene_reaction_rule: "YGR175C" - eccodes: "1.14.14.17" - subsystem: + - "Steroid biosynthesis" - annotation: !!omap - bigg.reaction: "SQLErx" - kegg.pathway: @@ -48353,6 +49073,7 @@ - gene_reaction_rule: "YGR175C" - eccodes: "1.14.14.17" - subsystem: + - "Steroid biosynthesis" - annotation: !!omap - bigg.reaction: "SQLEr" - kegg.pathway: @@ -48380,6 +49101,7 @@ - gene_reaction_rule: "YHR190W" - eccodes: "2.5.1.21" - subsystem: + - "Steroid biosynthesis" - annotation: !!omap - bigg.reaction: "SQLS" - kegg.pathway: @@ -48404,6 +49126,7 @@ - gene_reaction_rule: "(YDR178W and YJL045W and YKL141W and YLL041C) or (YDR178W and YKL141W and YKL148C and YLL041C) or (YLR164W and YJL045W and YKL141W and YLL041C)" - eccodes: "1.3.5.1" - subsystem: + - "Citrate cycle (TCA cycle)" - annotation: !!omap - bigg.reaction: "SUCD2_u6m" - kegg.pathway: @@ -48431,6 +49154,7 @@ - gene_reaction_rule: "YGR244C and YOR142W" - eccodes: "6.2.1.5" - subsystem: + - "Citrate cycle (TCA cycle)" - annotation: !!omap - bigg.reaction: "SUCOASm" - kegg.pathway: @@ -48459,6 +49183,7 @@ - gene_reaction_rule: "YBR006W" - eccodes: "1.2.1.16" - subsystem: + - "Alanine, aspartate and glutamate metabolism" - annotation: !!omap - bigg.reaction: "SSALy" - kegg.pathway: @@ -48485,6 +49210,7 @@ - gene_reaction_rule: "YIL162W" - eccodes: "3.2.1.26" - subsystem: + - "Starch and sucrose metabolism" - annotation: !!omap - bigg.reaction: "SUCRe" - kegg.pathway: @@ -48508,6 +49234,7 @@ - gene_reaction_rule: "YJR010W" - eccodes: "2.7.7.4" - subsystem: + - "Sulfur metabolism" - annotation: !!omap - bigg.reaction: "SADT" - kegg.pathway: @@ -48537,6 +49264,7 @@ - "2.7.7.5" - "2.7.7.53" - subsystem: + - "Sulfur metabolism" - annotation: !!omap - bigg.reaction: "SLFAT" - kegg.pathway: @@ -48562,6 +49290,7 @@ - gene_reaction_rule: "YFR030W and YJR137C" - eccodes: "1.8.1.2" - subsystem: + - "Sulfur metabolism" - annotation: !!omap - bigg.reaction: "SULR" - kegg.pathway: "sce00920" @@ -48584,6 +49313,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YLL048C" - subsystem: + - "Transport [c, v]" - annotation: !!omap - metanetx.reaction: "MNXR104744" - pubmed: "9182565" @@ -48606,6 +49336,7 @@ - gene_reaction_rule: "YLL057C" - eccodes: "1.14.11.-" - subsystem: + - "Sulfur metabolism" - annotation: !!omap - bigg.reaction: "TAUDO" - kegg.reaction: "R05320" @@ -48629,6 +49360,7 @@ - "1.8.1.4" - "2.1.2.10" - subsystem: + - "One carbon pool by folate" - annotation: !!omap - bigg.reaction: "THFATm" - kegg.pathway: @@ -48663,6 +49395,7 @@ - gene_reaction_rule: "YKL132C or YOR241W" - eccodes: "6.3.2.17" - subsystem: + - "Folate biosynthesis" - annotation: !!omap - bigg.reaction: "THFGLUS" - kegg.pathway: "sce00790" @@ -48687,6 +49420,7 @@ - gene_reaction_rule: "YBR092C" - eccodes: "3.1.3.2" - subsystem: + - "Thiamine metabolism" - annotation: !!omap - bigg.reaction: "THMDPe" - kegg.pathway: @@ -48708,6 +49442,7 @@ - gene_reaction_rule: "YBR092C" - eccodes: "3.1.3.2" - subsystem: + - "Thiamine metabolism" - annotation: !!omap - bigg.reaction: "THMPe" - kegg.pathway: @@ -48731,6 +49466,7 @@ - gene_reaction_rule: "YOR143C" - eccodes: "2.7.6.2" - subsystem: + - "Thiamine metabolism" - annotation: !!omap - bigg.reaction: "TMDPK" - kegg.pathway: "sce00730" @@ -48751,6 +49487,7 @@ - gene_reaction_rule: "YOR143C" - eccodes: "2.7.6.2" - subsystem: + - "Thiamine metabolism" - annotation: !!omap - bigg.reaction: "TMDPPK" - kegg.pathway: "sce00730" @@ -48774,6 +49511,7 @@ - "2.5.1.3" - "2.7.1.50" - subsystem: + - "Thiamine metabolism" - annotation: !!omap - bigg.reaction: "TMPPP" - kegg.pathway: "sce00730" @@ -48795,6 +49533,7 @@ - gene_reaction_rule: "(YGR209C and YIL010W) or (YIL010W and YLR043C)" - eccodes: "1.11.1.15" - subsystem: + - "Glutathione metabolism" - annotation: !!omap - bigg.reaction: "THIORDXni" - metanetx.reaction: "MNXR104815" @@ -48814,6 +49553,7 @@ - gene_reaction_rule: "(YDR353W and YGR209C) or (YDR353W and YLR043C) or YDR353W" - eccodes: "1.8.1.9" - subsystem: + - "Glutathione metabolism" - annotation: !!omap - bigg.reaction: "TRDR" - kegg.pathway: "sce00450" @@ -48836,6 +49576,7 @@ - "1.8.1.7" - "1.8.1.9" - subsystem: + - "Glutathione metabolism" - annotation: !!omap - bigg.reaction: "TRDRm" - kegg.pathway: @@ -48858,6 +49599,7 @@ - gene_reaction_rule: "YEL046C" - eccodes: "4.1.2.48" - subsystem: + - "Glycine, serine and threonine metabolism" - annotation: !!omap - bigg.reaction: "THRA" - kegg.pathway: @@ -48883,6 +49625,7 @@ - gene_reaction_rule: "YCR053W" - eccodes: "4.2.3.1" - subsystem: + - "Glycine, serine and threonine metabolism" - annotation: !!omap - bigg.reaction: "THRS" - kegg.pathway: @@ -48910,6 +49653,7 @@ - gene_reaction_rule: "YIL078W" - eccodes: "6.1.1.3" - subsystem: + - "tRNA metabolism" - annotation: !!omap - bigg.reaction: "THRTRS" - kegg.pathway: "sce00970" @@ -48933,6 +49677,7 @@ - gene_reaction_rule: "YKL194C" - eccodes: "6.1.1.3" - subsystem: + - "tRNA metabolism" - annotation: !!omap - bigg.reaction: "THRTRSm" - kegg.pathway: "sce00970" @@ -48954,6 +49699,7 @@ - gene_reaction_rule: "YOR074C" - eccodes: "2.1.1.45" - subsystem: + - "Pyrimidine metabolism" - annotation: !!omap - bigg.reaction: "TMDS" - kegg.pathway: @@ -48976,6 +49722,7 @@ - gene_reaction_rule: "YER175C" - eccodes: "2.1.1.145" - subsystem: + - "C5-branched dibasic acid metabolism" - annotation: !!omap - bigg.reaction: "ACONMT" - kegg.reaction: "R05763" @@ -48996,6 +49743,7 @@ - gene_reaction_rule: "YBR003W" - eccodes: "2.5.1.-" - subsystem: + - "Terpenoid backbone biosynthesis" - annotation: !!omap - bigg.reaction: "PPTTm" - kegg.pathway: @@ -49019,6 +49767,7 @@ - gene_reaction_rule: "YGR043C or YLR354C" - eccodes: "2.2.1.2" - subsystem: + - "Pentose phosphate pathway" - annotation: !!omap - bigg.reaction: "TALA" - kegg.pathway: @@ -49044,6 +49793,7 @@ - gene_reaction_rule: "YBR117C or YPR074C" - eccodes: "2.2.1.1" - subsystem: + - "Pentose phosphate pathway" - annotation: !!omap - bigg.reaction: "TKT1" - kegg.pathway: @@ -49069,6 +49819,7 @@ - gene_reaction_rule: "YBR117C or YPR074C" - eccodes: "2.2.1.1" - subsystem: + - "Pentose phosphate pathway" - annotation: !!omap - bigg.reaction: "TKT2" - kegg.pathway: @@ -49095,6 +49846,7 @@ - "2.4.1.15" - "3.1.3.12" - subsystem: + - "Starch and sucrose metabolism" - annotation: !!omap - bigg.reaction: "TRE6PP" - kegg.pathway: "sce00500" @@ -49114,6 +49866,7 @@ - gene_reaction_rule: "YDR050C" - eccodes: "5.3.1.1" - subsystem: + - "Glycolysis / gluconeogenesis" - annotation: !!omap - bigg.reaction: "TPI" - kegg.pathway: @@ -49143,6 +49896,7 @@ - gene_reaction_rule: "YGL026C" - eccodes: "4.2.1.20" - subsystem: + - "Phenylalanine, tyrosine and tryptophan biosynthesis" - annotation: !!omap - bigg.reaction: "TRPS1" - kegg.pathway: @@ -49170,6 +49924,7 @@ - "2.6.1.39" - "2.6.1.57" - subsystem: + - "Phenylalanine, tyrosine and tryptophan biosynthesis" - annotation: !!omap - bigg.reaction: "TRPTA" - kegg.pathway: @@ -49206,6 +49961,7 @@ - gene_reaction_rule: "YOL097C" - eccodes: "6.1.1.2" - subsystem: + - "tRNA metabolism" - annotation: !!omap - bigg.reaction: "TRPTRS" - kegg.pathway: "sce00970" @@ -49229,6 +49985,7 @@ - gene_reaction_rule: "YDR268W" - eccodes: "6.1.1.2" - subsystem: + - "tRNA metabolism" - annotation: !!omap - bigg.reaction: "TRPTRSm" - kegg.pathway: "sce00970" @@ -49252,6 +50009,7 @@ - "2.6.1.39" - "2.6.1.57" - subsystem: + - "Tyrosine metabolism" - annotation: !!omap - bigg.reaction: "TYRTA" - kegg.pathway: @@ -49286,6 +50044,7 @@ - gene_reaction_rule: "YLR027C" - eccodes: "2.6.1.1" - subsystem: + - "Tyrosine metabolism" - annotation: !!omap - bigg.reaction: "TYRTAip" - kegg.pathway: @@ -49320,6 +50079,7 @@ - gene_reaction_rule: "YGR185C" - eccodes: "6.1.1.1" - subsystem: + - "tRNA metabolism" - annotation: !!omap - bigg.reaction: "TYRTRS" - kegg.pathway: "sce00970" @@ -49343,6 +50103,7 @@ - gene_reaction_rule: "YPL097W" - eccodes: "6.1.1.1" - subsystem: + - "tRNA metabolism" - annotation: !!omap - bigg.reaction: "TYRTRSm" - kegg.pathway: "sce00970" @@ -49365,6 +50126,7 @@ - gene_reaction_rule: "YLR189C" - eccodes: "2.4.1.173" - subsystem: + - "Steroid biosynthesis" - annotation: !!omap - bigg.reaction: "ERGSTGLCT" - pubmed: "10224056" @@ -49384,6 +50146,7 @@ - gene_reaction_rule: "YDL103C" - eccodes: "2.7.7.23" - subsystem: + - "Amino sugar and nucleotide sugar metabolism" - annotation: !!omap - kegg.pathway: - "sce00520" @@ -49406,6 +50169,7 @@ - "5.1.3.2" - "5.1.3.3" - subsystem: + - "Galactose metabolism" - annotation: !!omap - bigg.reaction: "UDPG4E" - kegg.pathway: @@ -49431,6 +50195,7 @@ - gene_reaction_rule: "YBR018C" - eccodes: "2.7.7.12" - subsystem: + - "Galactose metabolism" - annotation: !!omap - bigg.reaction: "UGLT" - kegg.pathway: @@ -49453,6 +50218,7 @@ - gene_reaction_rule: "YKL024C" - eccodes: "2.7.4.14" - subsystem: + - "Pyrimidine metabolism" - annotation: !!omap - bigg.reaction: "UMPK" - kegg.pathway: "sce00240" @@ -49473,6 +50239,7 @@ - gene_reaction_rule: "YKL024C" - eccodes: "2.7.4.14" - subsystem: + - "Pyrimidine metabolism" - annotation: !!omap - bigg.reaction: "UMPKn" - kegg.pathway: "sce00240" @@ -49493,6 +50260,7 @@ - gene_reaction_rule: "YHR128W" - eccodes: "2.4.2.9" - subsystem: + - "Pyrimidine metabolism" - annotation: !!omap - bigg.reaction: "UPPRT" - kegg.pathway: "sce00240" @@ -49518,6 +50286,7 @@ - "3.5.1.54" - "6.3.4.6" - subsystem: + - "Arginine biosynthesis" - annotation: !!omap - bigg.reaction: "UREASE" - kegg.pathway: @@ -49542,6 +50311,7 @@ - gene_reaction_rule: "YIR032C" - eccodes: "4.3.2.3" - subsystem: + - "Purine metabolism" - annotation: !!omap - bigg.reaction: "UGLYCH" - kegg.pathway: "sce00230" @@ -49564,6 +50334,7 @@ - gene_reaction_rule: "YDR020C or YNR012W" - eccodes: "2.7.1.48" - subsystem: + - "Pyrimidine metabolism" - annotation: !!omap - bigg.reaction: "URIK1" - kegg.pathway: "sce00240" @@ -49585,6 +50356,7 @@ - gene_reaction_rule: "YDR020C or YNR012W" - eccodes: "2.7.1.48" - subsystem: + - "Pyrimidine metabolism" - annotation: !!omap - bigg.reaction: "URIK2" - kegg.pathway: "sce00240" @@ -49605,6 +50377,7 @@ - gene_reaction_rule: "YKL024C" - eccodes: "2.7.4.14" - subsystem: + - "Pyrimidine metabolism" - annotation: !!omap - bigg.reaction: "URIDK2r" - kegg.pathway: "sce00240" @@ -49625,6 +50398,7 @@ - gene_reaction_rule: "YKL024C" - eccodes: "2.7.4.14" - subsystem: + - "Pyrimidine metabolism" - annotation: !!omap - bigg.reaction: "URIDK2rn" - kegg.pathway: "sce00240" @@ -49645,6 +50419,7 @@ - gene_reaction_rule: "YDR047W" - eccodes: "4.1.1.37" - subsystem: + - "Porphyrin and chlorophyll metabolism" - annotation: !!omap - bigg.reaction: "UPPDC1" - kegg.pathway: @@ -49668,6 +50443,7 @@ - gene_reaction_rule: "YKR069W" - eccodes: "2.1.1.107" - subsystem: + - "Porphyrin and chlorophyll metabolism" - annotation: !!omap - bigg.reaction: "UPP3MT" - kegg.pathway: @@ -49689,6 +50465,7 @@ - gene_reaction_rule: "YOR278W" - eccodes: "4.2.1.75" - subsystem: + - "Porphyrin and chlorophyll metabolism" - annotation: !!omap - bigg.reaction: "UPP3S" - kegg.pathway: @@ -49712,6 +50489,7 @@ - gene_reaction_rule: "YHL012W or YKL035W" - eccodes: "2.7.7.9" - subsystem: + - "Galactose metabolism" - annotation: !!omap - bigg.reaction: "GALUi" - kegg.pathway: @@ -49737,11 +50515,12 @@ - s_1322: 1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "YBR127C and YDL185W and YEL027W and YEL051W and YGR020C and YHR026W and YHR039C-A and YKL080W and YLR447C and YMR054W and YOR332W and YPL234C and YPR036W" + - gene_reaction_rule: "(YPR170W-B and YBR127C and YDL185W and YOR332W and YHR026W and YEL027W and YKL080W and YLR447C and YEL051W and YPL234C and YMR054W and YGR020C and YPR036W and YHR039C-A and YGR106C and YCL005W-A) or (YBR127C and YDL185W and YOR332W and YHR026W and YEL027W and YKL080W and YLR447C and YEL051W and YPL234C and YMR054W and YGR020C and YPR036W and YHR039C-A and YGR106C and YCL005W-A)" - eccodes: - "3.1.-.-" - "3.6.3.14" - subsystem: + - "Oxidative phosphorylation" - annotation: !!omap - kegg.pathway: - "sce00190" @@ -49764,11 +50543,12 @@ - s_1322: 1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "YBR127C and YDL185W and YEL027W and YEL051W and YGR020C and YHR026W and YHR039C-A and YKL080W and YLR447C and YOR270C and YOR332W and YPL234C and YPR036W" + - gene_reaction_rule: "(YBR127C and YDL185W and YEL027W and YEL051W and YGR020C and YHR026W and YHR039C-A and YKL080W and YLR447C and YOR270C and YOR332W and YPL234C and YPR036W and YPR170W-B and YGR106C and YCL005W-A) or (YBR127C and YDL185W and YEL027W and YEL051W and YGR020C and YHR026W and YHR039C-A and YKL080W and YLR447C and YOR270C and YOR332W and YPL234C and YPR036W and YGR106C and YCL005W-A)" - eccodes: - "3.1.-.-" - "3.6.3.14" - subsystem: + - "Oxidative phosphorylation" - annotation: !!omap - kegg.pathway: - "sce00190" @@ -49792,6 +50572,7 @@ - gene_reaction_rule: "YJR148W" - eccodes: "2.6.1.42" - subsystem: + - "Valine, leucine and isoleucine metabolism" - annotation: !!omap - bigg.reaction: "VALTA" - kegg.pathway: @@ -49821,6 +50602,7 @@ - gene_reaction_rule: "YHR208W" - eccodes: "2.6.1.42" - subsystem: + - "Valine, leucine and isoleucine metabolism" - annotation: !!omap - bigg.reaction: "VALTAim" - kegg.pathway: @@ -49852,6 +50634,7 @@ - gene_reaction_rule: "YGR094W" - eccodes: "6.1.1.9" - subsystem: + - "tRNA metabolism" - annotation: !!omap - bigg.reaction: "VALTRS" - kegg.pathway: "sce00970" @@ -49875,6 +50658,7 @@ - gene_reaction_rule: "YGR094W" - eccodes: "6.1.1.9" - subsystem: + - "tRNA metabolism" - annotation: !!omap - bigg.reaction: "VALTRSm" - kegg.pathway: "sce00970" @@ -49896,6 +50680,7 @@ - gene_reaction_rule: "YJR133W" - eccodes: "2.4.2.-" - subsystem: + - "Purine metabolism" - annotation: !!omap - bigg.reaction: "XPPT" - kegg.reaction: "R02142" @@ -49916,6 +50701,7 @@ - gene_reaction_rule: "YLR070C" - eccodes: "1.1.1.9" - subsystem: + - "Pentose and glucuronate interconversions" - annotation: !!omap - bigg.reaction: "XYLTD_D" - kegg.pathway: "sce00040" @@ -49939,6 +50725,7 @@ - "1.1.1.-" - "1.1.1.21" - subsystem: + - "Pentose and glucuronate interconversions" - annotation: !!omap - bigg.reaction: "XYLR" - kegg.pathway: "sce00040" @@ -49960,6 +50747,7 @@ - gene_reaction_rule: "YGR194C" - eccodes: "2.7.1.17" - subsystem: + - "Pentose and glucuronate interconversions" - annotation: !!omap - bigg.reaction: "XYLK" - kegg.pathway: "sce00040" @@ -49984,6 +50772,7 @@ - "5.4.99.44" - "5.4.99.45" - subsystem: + - "Pyrimidine metabolism" - annotation: !!omap - sbo: "SBO:0000176" - confidence_score: 2 @@ -49995,7 +50784,9 @@ - s_0029: -1 - lower_bound: -1000 - upper_bound: 1000 + - gene_reaction_rule: "YNL065W or YKL217W" - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "MEV_Rt" - metanetx.reaction: "MNXR105406" @@ -50011,6 +50802,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "BTDt_RR" - metanetx.reaction: "MNXR136615" @@ -50026,6 +50818,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "2MBACt" - metanetx.reaction: "MNXR94808" @@ -50044,6 +50837,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YOR222W or YPL134C" - subsystem: + - "Transport [c, m]" - annotation: !!omap - bigg.reaction: "2OXOADPTm" - metanetx.reaction: "MNXR94819" @@ -50061,6 +50855,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, m]" - annotation: !!omap - bigg.reaction: "3DH5HPBtm" - metanetx.reaction: "MNXR94863" @@ -50079,6 +50874,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YDL210W or YOR348C" - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "ABUTt2r" - metanetx.reaction: "MNXR94994" @@ -50096,6 +50892,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YDL210W" - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "5AOPt2" - metanetx.reaction: "MNXR95061" @@ -50110,6 +50907,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, e]" - annotation: !!omap - metanetx.reaction: "MNXR95074" - pubmed: "8573145" @@ -50127,6 +50925,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YNR056C" - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "8AONNt2" - metanetx.reaction: "MNXR95113" @@ -50143,6 +50942,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YCR010C" - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "ACtr" - metanetx.reaction: "MNXR95431" @@ -50158,6 +50958,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Transport [c, e]" - annotation: !!omap - pubmed: "10653746" - sbo: "SBO:0000655" @@ -50172,8 +50973,9 @@ - s_0796: -1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "YER056C or YER060W or YER060W-A or YGL186C" + - gene_reaction_rule: "YER056C or YER060W or YER060W-A" - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "ADEt2" - metanetx.reaction: "MNXR95446" @@ -50191,6 +50993,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YAL022C" - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "ADNt2" - metanetx.reaction: "MNXR95461" @@ -50209,6 +51012,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YBL030C or YBR085W or YMR056C" - subsystem: + - "Transport [c, m]" - annotation: !!omap - bigg.reaction: "ATPtm" - kegg.reaction: "R00124" @@ -50233,6 +51037,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YPR128C" - subsystem: + - "Transport [c, p]" - annotation: !!omap - bigg.reaction: "ATPtp_H" - metanetx.reaction: "MNXR96139" @@ -50250,6 +51055,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YMR241W" - subsystem: + - "Transport [c, m]" - annotation: !!omap - bigg.reaction: "AKGCITtm" - metanetx.reaction: "MNXR95654" @@ -50266,6 +51072,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YJR152W" - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "ALLTTti" - metanetx.reaction: "MNXR95773" @@ -50281,6 +51088,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YIR028W" - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "ALLTNti" - metanetx.reaction: "MNXR95771" @@ -50296,6 +51104,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YDR384C or YGR121C or YNL142W or YPR138C" - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "NH4t" - metanetx.reaction: "MNXR101950" @@ -50316,6 +51125,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YPR128C" - subsystem: + - "Transport [c, p]" - annotation: !!omap - bigg.reaction: "ATP2tp_H" - metanetx.reaction: "MNXR96125" @@ -50333,6 +51143,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YPR021C" - subsystem: + - "Transport [c, m]" - annotation: !!omap - bigg.reaction: "ASPGLU2m" - metanetx.reaction: "MNXR96083" @@ -50351,6 +51162,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YGR065C" - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "BTNt2i" - metanetx.reaction: "MNXR96334" @@ -50368,6 +51180,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YOR100C" - subsystem: + - "Transport [c, m]" - annotation: !!omap - bigg.reaction: "CRNCARtm" - metanetx.reaction: "MNXR96898" @@ -50382,6 +51195,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [er, g]" - annotation: !!omap - pubmed: "12484746" - sbo: "SBO:0000655" @@ -50395,6 +51209,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [er, g]" - annotation: !!omap - pubmed: "12484746" - sbo: "SBO:0000655" @@ -50408,6 +51223,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [er, g]" - annotation: !!omap - pubmed: "12484746" - sbo: "SBO:0000655" @@ -50421,6 +51237,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [er, g]" - annotation: !!omap - pubmed: "12484746" - sbo: "SBO:0000655" @@ -50437,6 +51254,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YGL077C" - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "CHLt2" - metanetx.reaction: "MNXR96692" @@ -50454,6 +51272,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YBR291C" - subsystem: + - "Transport [c, m]" - annotation: !!omap - bigg.reaction: "CITtam" - metanetx.reaction: "MNXR96753" @@ -50471,6 +51290,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YBR291C" - subsystem: + - "Transport [c, m]" - annotation: !!omap - bigg.reaction: "CITtbm" - metanetx.reaction: "MNXR96754" @@ -50488,6 +51308,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YBR291C" - subsystem: + - "Transport [c, m]" - annotation: !!omap - bigg.reaction: "CITtcm" - metanetx.reaction: "MNXR96755" @@ -50503,6 +51324,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YHR002W" - subsystem: + - "Transport [c, m]" - annotation: !!omap - bigg.reaction: "COAtim" - metanetx.reaction: "MNXR96815" @@ -50523,6 +51345,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YBR192W" - subsystem: + - "Transport [c, m]" - annotation: !!omap - pubmed: "16844075" - sbo: "SBO:0000655" @@ -50541,6 +51364,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YBR192W" - subsystem: + - "Transport [c, m]" - annotation: !!omap - bigg.reaction: "CTPtm" - metanetx.reaction: "MNXR96947" @@ -50559,6 +51383,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YAL022C" - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "CYTDt2" - metanetx.reaction: "MNXR97044" @@ -50577,6 +51402,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YER056C or YER060W or YER060W-A or YGL186C" - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "CSNt2" - metanetx.reaction: "MNXR96929" @@ -50594,6 +51420,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YDL245C or YDR342C or YDR343C or YDR345C or YEL069C or YFL011W or YHR092C or YHR094C or YHR096C or YJL214W or YJL219W or YJR158W or YMR011W or YNR072W or YOL156W" - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "FRUt2" - kegg.pathway: "sce04113" @@ -50610,8 +51437,9 @@ - s_0796: -1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "YDR536W or YFL011W or YJL219W or YLR081W or YNL318C or YOL156W" + - gene_reaction_rule: "YFL011W or YJL219W or YLR081W or YNL318C or YOL156W" - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "GALt2" - kegg.pathway: "sce04113" @@ -50630,6 +51458,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YKL217W" - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "D_LACt2" - metanetx.reaction: "MNXR97838" @@ -50646,6 +51475,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Transport [c, m]" - annotation: !!omap - bigg.reaction: "D_LACtm" - metanetx.reaction: "MNXR97838" @@ -50663,6 +51493,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, m]" - annotation: !!omap - bigg.reaction: "D_LACt2m" - metanetx.reaction: "MNXR97839" @@ -50679,8 +51510,9 @@ - s_0796: -1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "YDL245C or YDR342C or YDR343C or YDR345C or YEL069C or YFL011W or YHR092C or YHR094C or YHR096C or YJL214W or YJL219W or YJR158W or YMR011W or YNR072W or YOL156W" + - gene_reaction_rule: "YDL245C or YDR342C or YHR094C or YDR343C or YDR345C or YEL069C or YFL011W or YHR096C or YJL214W or YJL219W or YJR158W or YNR072W or YOL156W" - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "MANt2" - kegg.pathway: "sce04113" @@ -50697,6 +51529,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YIL013C or YOR011W" - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "EPISTt" - metanetx.reaction: "MNXR97944" @@ -50713,6 +51546,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YIL013C or YOR011W" - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "ERGSTt" - metanetx.reaction: "MNXR97950" @@ -50729,6 +51563,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YIL013C or YOR011W" - subsystem: + - "Transport [c, ce]" - annotation: !!omap - metanetx.reaction: "MNXR97950" - pubmed: "17434796" @@ -50744,6 +51579,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YGL077C" - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "ETHAt" - metanetx.reaction: "MNXR97974" @@ -50760,6 +51596,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YIL134W" - subsystem: + - "Transport [c, m]" - annotation: !!omap - bigg.reaction: "FADH2tm" - metanetx.reaction: "MNXR99212" @@ -50776,6 +51613,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YIL013C or YOR011W" - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "FECOSTt" - metanetx.reaction: "MNXR99529" @@ -50792,6 +51630,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YIL013C or YOR011W" - subsystem: + - "Transport [c, ce]" - annotation: !!omap - metanetx.reaction: "MNXR99529" - pubmed: "17434796" @@ -50806,6 +51645,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "r0963" - metanetx.reaction: "MNXR105408" @@ -50824,6 +51664,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YGL225W" - subsystem: + - "Transport [c, g]" - annotation: !!omap - bigg.reaction: "GDPMANNtg" - metanetx.reaction: "MNXR100090" @@ -50840,6 +51681,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YDL245C or YDL247W or YDR342C or YDR343C or YDR345C or YDR536W or YEL069C or YFL011W or YHR092C or YHR094C or YHR096C or YJL214W or YJL219W or YJR158W or YJR160C or YLR081W or YMR011W or YNR072W or YOL156W or YDR387C" - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "GLCt1" - kegg.pathway: "sce04113" @@ -50857,6 +51699,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YJL212C" - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "GTHRDt2" - metanetx.reaction: "MNXR100449" @@ -50873,6 +51716,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YDR135C or YLL015W" - subsystem: + - "Transport [c, v]" - annotation: !!omap - metanetx.reaction: "MNXR100449" - pubmed: "10790694" @@ -50888,6 +51732,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YCR098C" - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "G3PIt" - metanetx.reaction: "MNXR99888" @@ -50904,6 +51749,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YCR098C" - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "G3PCt" - metanetx.reaction: "MNXR99874" @@ -50922,6 +51768,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YDR536W or YGL084C or YPL189W" - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "GLYCt2" - metanetx.reaction: "MNXR100344" @@ -50940,6 +51787,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YFL054C or YLL043W" - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "GLYCt" - metanetx.reaction: "MNXR100343" @@ -50957,6 +51805,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YCL025C or YKR039W or YOL020W or YOR348C or YPL265W" - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "GLYt2r" - metanetx.reaction: "MNXR100368" @@ -50972,6 +51821,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Transport [c, v]" - annotation: !!omap - bigg.reaction: "GLCNtv" - metanetx.reaction: "MNXR100211" @@ -50992,6 +51842,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YDL198C" - subsystem: + - "Transport [c, m]" - annotation: !!omap - bigg.reaction: "GTPt2m" - metanetx.reaction: "MNXR100461" @@ -51008,8 +51859,9 @@ - s_0796: -1 - lower_bound: -1000 - upper_bound: 1000 - - gene_reaction_rule: "YER056C or YER060W or YER060W-A or YGL186C" + - gene_reaction_rule: "YER056C or YER060W or YER060W-A" - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "GUAt2r" - metanetx.reaction: "MNXR100466" @@ -51027,6 +51879,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YDR497C or YOL103W" - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "INSTt2" - metanetx.reaction: "MNXR100841" @@ -51042,6 +51895,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YMR319C or YMR058W" - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "FE2t" - metanetx.reaction: "MNXR99505" @@ -51058,6 +51912,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YJL133W or YKR052C" - subsystem: + - "Transport [c, m]" - annotation: !!omap - bigg.reaction: "FE2utm" - metanetx.reaction: "MNXR99505" @@ -51073,6 +51928,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "IAMACt" - metanetx.reaction: "MNXR100774" @@ -51088,6 +51944,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "IBUTACt" - metanetx.reaction: "MNXR100779" @@ -51103,6 +51960,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, m]" - annotation: !!omap - bigg.reaction: "IPDPtm" - metanetx.reaction: "MNXR100876" @@ -51119,8 +51977,9 @@ - s_0956: -1 - lower_bound: -1000 - upper_bound: 1000 - - gene_reaction_rule: "YBR068C or YCL025C or YDR046C or YKR039W or YOL020W or YOR348C or YPL265W" + - gene_reaction_rule: "YCL025C or YKR039W or YOR348C or YPL265W" - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "ALAt2r" - metanetx.reaction: "MNXR95704" @@ -51141,6 +52000,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YEL063C or YKR039W or YNL270C" - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "ARGt2r" - metanetx.reaction: "MNXR95953" @@ -51158,6 +52018,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YOL092W or YBR293W" - subsystem: + - "Transport [c, v]" - annotation: !!omap - bigg.reaction: "ARGt6" - metanetx.reaction: "MNXR95954" @@ -51176,6 +52037,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YCL025C or YDR508C or YKR039W or YPL265W" - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "ASNt2r" - metanetx.reaction: "MNXR96066" @@ -51194,6 +52056,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YJR001W" - subsystem: + - "Transport [c, v]" - annotation: !!omap - bigg.reaction: "ASNt6" - metanetx.reaction: "MNXR96067" @@ -51212,6 +52075,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YKL146W or YNL101W" - subsystem: + - "Transport [c, v]" - annotation: !!omap - bigg.reaction: "ASNt7" - kegg.pathway: "sce04138" @@ -51231,6 +52095,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YER119C" - subsystem: + - "Transport [c, v]" - annotation: !!omap - bigg.reaction: "ASPt7" - metanetx.reaction: "MNXR96106" @@ -51249,6 +52114,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YFL055W or YKR039W or YPL265W" - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "ASPt2r" - metanetx.reaction: "MNXR96106" @@ -51264,6 +52130,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YBR132C" - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "CRNt" - metanetx.reaction: "MNXR96906" @@ -51281,6 +52148,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YBR068C or YBR069C or YCL025C or YDR046C or YDR508C or YKR039W or YOL020W" - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "CYSt2r" - metanetx.reaction: "MNXR97027" @@ -51299,6 +52167,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YCR075C" - subsystem: + - "Transport [c, v]" - annotation: !!omap - bigg.reaction: "LCYSTintv" - metanetx.reaction: "MNXR101034" @@ -51315,6 +52184,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YPR021C" - subsystem: + - "Transport [c, m]" - annotation: !!omap - bigg.reaction: "GLUt7m" - metanetx.reaction: "MNXR100301" @@ -51333,6 +52203,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YER119C" - subsystem: + - "Transport [c, v]" - annotation: !!omap - bigg.reaction: "GLUt7" - metanetx.reaction: "MNXR100300" @@ -51351,6 +52222,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YCL025C or YFL055W or YKR039W or YPL265W" - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "GLUt2r" - metanetx.reaction: "MNXR100300" @@ -51368,6 +52240,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YJR001W" - subsystem: + - "Transport [c, v]" - annotation: !!omap - bigg.reaction: "GLNt6" - metanetx.reaction: "MNXR100262" @@ -51386,6 +52259,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YKL146W or YNL101W" - subsystem: + - "Transport [c, v]" - annotation: !!omap - bigg.reaction: "GLNt7" - kegg.pathway: "sce04138" @@ -51405,6 +52279,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YCL025C or YDR508C or YKR039W or YPL265W" - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "GLNt2r" - metanetx.reaction: "MNXR100260" @@ -51422,6 +52297,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YOL092W or YBR293W or YCL069W or YMR088C" - subsystem: + - "Transport [c, v]" - annotation: !!omap - bigg.reaction: "HISt6" - metanetx.reaction: "MNXR100647" @@ -51440,6 +52316,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YBR069C or YGR191W or YKR039W" - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "HISt2r" - metanetx.reaction: "MNXR100645" @@ -51455,6 +52332,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YCL038C" - subsystem: + - "Transport [c, v]" - annotation: !!omap - kegg.pathway: "sce04138" - metanetx.reaction: "MNXR100824" @@ -51473,6 +52351,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YJR001W" - subsystem: + - "Transport [c, v]" - annotation: !!omap - bigg.reaction: "ILEt6" - metanetx.reaction: "MNXR100825" @@ -51491,6 +52370,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YKL146W or YNL101W" - subsystem: + - "Transport [c, v]" - annotation: !!omap - bigg.reaction: "ILEt7" - kegg.pathway: "sce04138" @@ -51510,6 +52390,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YBR068C or YBR069C or YCL025C or YDR046C or YKR039W" - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "ILEt2r" - metanetx.reaction: "MNXR100822" @@ -51525,6 +52406,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YKL217W" - subsystem: + - "Transport [c, m]" - annotation: !!omap - bigg.reaction: "L_LACtcm" - metanetx.reaction: "MNXR100999" @@ -51543,6 +52425,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YKL217W" - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "L_LACt2r" - metanetx.reaction: "MNXR101277" @@ -51559,6 +52442,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YCL038C" - subsystem: + - "Transport [c, v]" - annotation: !!omap - kegg.pathway: "sce04138" - metanetx.reaction: "MNXR101057" @@ -51577,6 +52461,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YJR001W" - subsystem: + - "Transport [c, v]" - annotation: !!omap - bigg.reaction: "LEUt6" - metanetx.reaction: "MNXR101058" @@ -51595,6 +52480,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YKL146W or YNL101W" - subsystem: + - "Transport [c, v]" - annotation: !!omap - bigg.reaction: "LEUt7" - kegg.pathway: "sce04138" @@ -51614,6 +52500,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YBR068C or YBR069C or YCL025C or YDR046C or YDR508C or YKR039W" - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "LEUt2r" - metanetx.reaction: "MNXR101055" @@ -51631,6 +52518,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YOL092W or YBR293W or YCL069W or YMR088C" - subsystem: + - "Transport [c, v]" - annotation: !!omap - bigg.reaction: "LYSt6" - metanetx.reaction: "MNXR101267" @@ -51649,6 +52537,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YKR039W or YNL268W" - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "LYSt2r" - metanetx.reaction: "MNXR101266" @@ -51666,6 +52555,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YBR068C or YCL025C or YDR046C or YDR508C or YGR055W or YHL036W or YKR039W" - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "METt2r" - metanetx.reaction: "MNXR101490" @@ -51683,6 +52573,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YBR068C or YCL025C or YDR046C or YKR039W or YOL020W" - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "PHEt2r" - metanetx.reaction: "MNXR102635" @@ -51700,6 +52591,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YKR039W or YOR348C" - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "PROt2r" - metanetx.reaction: "MNXR103211" @@ -51717,6 +52609,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YCL025C or YDR508C or YFL055W or YKR039W or YPL265W or YDR105C" - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "SERt2r" - metanetx.reaction: "MNXR104352" @@ -51732,8 +52625,9 @@ - s_1046: -1 - lower_bound: -1000 - upper_bound: 1000 - - gene_reaction_rule: "YBR069C or YCL025C or YDR046C or YDR508C or YKR039W" + - gene_reaction_rule: "YCL025C or YDR508C or YKR039W" - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "THRt2r" - metanetx.reaction: "MNXR104850" @@ -51752,6 +52646,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YBR068C or YBR069C or YDR046C or YKR039W or YOL020W" - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "TRPt2r" - metanetx.reaction: "MNXR104950" @@ -51768,6 +52663,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YCL038C" - subsystem: + - "Transport [c, v]" - annotation: !!omap - kegg.pathway: "sce04138" - metanetx.reaction: "MNXR105002" @@ -51786,6 +52682,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YBR293W or YJR001W" - subsystem: + - "Transport [c, v]" - annotation: !!omap - bigg.reaction: "TYRt6" - metanetx.reaction: "MNXR105005" @@ -51804,6 +52701,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YKL146W or YNL101W" - subsystem: + - "Transport [c, v]" - annotation: !!omap - bigg.reaction: "TYRt7" - kegg.pathway: "sce04138" @@ -51823,6 +52721,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YBR068C or YBR069C or YCL025C or YDR046C or YKR039W or YOL020W" - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "TYRt2r" - metanetx.reaction: "MNXR105003" @@ -51840,6 +52739,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YBR068C or YBR069C or YCL025C or YDR046C or YKR039W" - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "VALt2r" - metanetx.reaction: "MNXR105188" @@ -51855,6 +52755,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YIL013C or YOR011W" - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "LANOSTt" - metanetx.reaction: "MNXR101014" @@ -51873,6 +52774,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YLR348C" - subsystem: + - "Transport [c, m]" - annotation: !!omap - bigg.reaction: "MALtm" - metanetx.reaction: "MNXR101374" @@ -51890,6 +52792,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YBR298C or YDL247W or YGR289C or YJR160C" - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "MALTt2" - metanetx.reaction: "MNXR101365" @@ -51906,6 +52809,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YBR180W" - subsystem: + - "Transport [c, e]" - annotation: !!omap - pubmed: "12455697" - sbo: "SBO:0000655" @@ -51920,6 +52824,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YEL006W or YIL006W" - subsystem: + - "Transport [c, m]" - annotation: !!omap - bigg.reaction: "NADtm" - metanetx.reaction: "MNXR101900" @@ -51940,6 +52845,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YIL006W" - subsystem: + - "Transport [c, m]" - annotation: !!omap - pubmed: "16291748" - sbo: "SBO:0000655" @@ -51956,6 +52862,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YIL006W" - subsystem: + - "Transport [c, m]" - annotation: !!omap - pubmed: "16291748" - sbo: "SBO:0000655" @@ -51972,6 +52879,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YIL006W" - subsystem: + - "Transport [c, m]" - annotation: !!omap - pubmed: "16291748" - sbo: "SBO:0000655" @@ -51986,6 +52894,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YGR260W" - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "NACt" - metanetx.reaction: "MNXR101808" @@ -52002,6 +52911,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YKL188C and YPL147W" - subsystem: + - "Transport [c, p]" - annotation: !!omap - metanetx.reaction: "MNXR99109" - pubmed: "8993619" @@ -52019,6 +52929,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YOR130C" - subsystem: + - "Transport [c, m]" - annotation: !!omap - bigg.reaction: "ORNt3m" - metanetx.reaction: "MNXR102225" @@ -52035,8 +52946,9 @@ - s_1267: -1 - lower_bound: -1000 - upper_bound: 1000 - - gene_reaction_rule: "YEL063C or YKR039W" + - gene_reaction_rule: "YKR039W" - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "ORNt2r" - metanetx.reaction: "MNXR102224" @@ -52054,6 +52966,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YKL120W" - subsystem: + - "Transport [c, m]" - annotation: !!omap - bigg.reaction: "OAAt2m" - metanetx.reaction: "MNXR102102" @@ -52071,6 +52984,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YCR028C" - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "PNTOt2" - metanetx.reaction: "MNXR103053" @@ -52085,6 +52999,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, m]" - annotation: !!omap - bigg.reaction: "PENDPtm" - metanetx.reaction: "MNXR102483" @@ -52100,6 +53015,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "PHEACt" - metanetx.reaction: "MNXR102622" @@ -52118,6 +53034,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YBR296C or YCR037C or YJL198W or YML123C or YNR013C" - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "PIt2r" - metanetx.reaction: "MNXR102872" @@ -52135,6 +53052,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YER053C or YJR077C" - subsystem: + - "Transport [c, m]" - annotation: !!omap - bigg.reaction: "PIt2m" - metanetx.reaction: "MNXR102872" @@ -52152,6 +53070,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YDR456W or YJL129C" - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "Kt2r" - pubmed: "3043197" @@ -52167,6 +53086,7 @@ - upper_bound: 0 - gene_reaction_rule: "YKL174C" - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "PTRCtex2" - metanetx.reaction: "MNXR103339" @@ -52185,6 +53105,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YLL028W or YOR273C" - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "PTRCt3i" - metanetx.reaction: "MNXR103341" @@ -52203,6 +53124,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YLL028W or YOR273C" - subsystem: + - "Transport [c, v]" - annotation: !!omap - metanetx.reaction: "MNXR103341" - pubmed: "11171066" @@ -52220,6 +53142,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YGL186C" - subsystem: + - "Transport [c, e]" - annotation: !!omap - pubmed: "12649274" - sbo: "SBO:0000655" @@ -52236,6 +53159,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YKL217W" - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "PYRt2" - metanetx.reaction: "MNXR103385" @@ -52253,6 +53177,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YPL274W" - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "AMETt2" - metanetx.reaction: "MNXR95810" @@ -52268,6 +53193,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YNL003C" - subsystem: + - "Transport [c, m]" - annotation: !!omap - bigg.reaction: "AMETtm" - metanetx.reaction: "MNXR95809" @@ -52286,6 +53212,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YLL061W" - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "MMETt2" - metanetx.reaction: "MNXR101658" @@ -52303,6 +53230,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YDR456W or YLR138W" - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "NAt3_1" - sbo: "SBO:0000655" @@ -52317,6 +53245,7 @@ - upper_bound: 0 - gene_reaction_rule: "YKL174C" - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "SPMDtex2" - metanetx.reaction: "MNXR104495" @@ -52335,6 +53264,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YBR132C or YHL016C or YKR039W or YLL028W or YOR273C or YPL274W" - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "SPMDt3i" - metanetx.reaction: "MNXR104497" @@ -52355,6 +53285,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YLL028W or YOR273C" - subsystem: + - "Transport [c, v]" - annotation: !!omap - metanetx.reaction: "MNXR104497" - pubmed: "11171066" @@ -52372,6 +53303,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YGR138C or YLL028W or YOR273C or YPR156C" - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "SPRMt2i" - metanetx.reaction: "MNXR104501" @@ -52390,6 +53322,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YGR138C or YLL028W or YOR273C or YPR156C" - subsystem: + - "Transport [c, v]" - annotation: !!omap - metanetx.reaction: "MNXR104501" - pubmed: "11171066" @@ -52407,6 +53340,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YLR348C" - subsystem: + - "Transport [c, m]" - annotation: !!omap - bigg.reaction: "SUCCtm" - metanetx.reaction: "MNXR104626" @@ -52424,6 +53358,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YJR095W" - subsystem: + - "Transport [c, m]" - annotation: !!omap - bigg.reaction: "SUCFUMtm" - metanetx.reaction: "MNXR104633" @@ -52440,6 +53375,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YBR294W or YLR092W" - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "SO4ti" - metanetx.reaction: "MNXR104469" @@ -52455,6 +53391,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YPL092W" - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "SO3ti" - metanetx.reaction: "MNXR104460" @@ -52470,6 +53407,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "TAURt" - metanetx.reaction: "MNXR104733" @@ -52486,6 +53424,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YGR096W" - subsystem: + - "Transport [c, m]" - annotation: !!omap - bigg.reaction: "THMPPt2m" - metanetx.reaction: "MNXR104824" @@ -52504,6 +53443,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YLR237W or YOR071C or YOR192C" - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "THMt2" - metanetx.reaction: "MNXR138863" @@ -52519,6 +53459,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YPL244C" - subsystem: + - "Transport [c, g]" - annotation: !!omap - bigg.reaction: "UDPGALt2g" - metanetx.reaction: "MNXR105061" @@ -52537,6 +53478,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YBR021W" - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "URAt2" - metanetx.reaction: "MNXR105148" @@ -52554,6 +53496,7 @@ - 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annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -52743,6 +53697,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -52757,6 +53712,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -52771,6 +53727,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -52785,6 +53742,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -52799,6 +53757,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -52813,6 +53772,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -52827,6 +53787,7 @@ - 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"SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -52925,6 +53892,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -52939,6 +53907,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -52953,6 +53922,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -52967,6 +53937,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -52981,6 +53952,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -52995,6 +53967,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - 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metanetx.reaction: "MNXR94810" @@ -53373,6 +54376,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_2mbald_e" - sbo: "SBO:0000627" @@ -53385,6 +54389,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "2MBALDt" - metanetx.reaction: "MNXR94809" @@ -53399,6 +54404,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, m]" - annotation: !!omap - bigg.reaction: "2MBALDtm" - metanetx.reaction: "MNXR94809" @@ -53412,6 +54418,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_2mbtoh_e" - sbo: "SBO:0000627" @@ -53423,6 +54430,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_2mbac_e" - sbo: "SBO:0000627" @@ -53435,6 +54443,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, e]" - 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sbo: "SBO:0000655" @@ -53513,6 +54528,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_2phetoh_e" - sbo: "SBO:0000627" @@ -53525,6 +54541,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "2PHETOHt" - metanetx.reaction: "MNXR94828" @@ -53539,6 +54556,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, m]" - annotation: !!omap - bigg.reaction: "2PHETOHtm" - metanetx.reaction: "MNXR94828" @@ -53553,6 +54571,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, m]" - annotation: !!omap - bigg.reaction: "3C4MOPtm" - metanetx.reaction: "MNXR94859" @@ -53567,6 +54586,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, m]" - annotation: !!omap - bigg.reaction: "3MOPtm" - metanetx.reaction: "MNXR94926" @@ -53581,6 +54601,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "3MOPt" - metanetx.reaction: "MNXR94926" @@ -53594,6 +54615,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_3mbald_e" - sbo: "SBO:0000627" @@ -53606,6 +54628,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "3MBALDt" - metanetx.reaction: "MNXR137944" @@ -53620,6 +54643,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, m]" - annotation: !!omap - bigg.reaction: "3MBALDtm" - metanetx.reaction: "MNXR137944" @@ -53634,6 +54658,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, m]" - annotation: !!omap - bigg.reaction: "3OPHB_5tm" - metanetx.reaction: "MNXR94966" @@ -53652,6 +54677,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YFL058W" - subsystem: + - "Thiamine metabolism" - annotation: !!omap - bigg.reaction: "AHMMPS" - metanetx.reaction: "MNXR95632" @@ -53665,6 +54691,7 @@ - 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metanetx.reaction: "MNXR95001" @@ -53747,6 +54779,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, p]" - annotation: !!omap - bigg.reaction: "4H2OGLTtp" - metanetx.reaction: "MNXR95001" @@ -53761,6 +54794,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, m]" - annotation: !!omap - bigg.reaction: "4HBZtm" - metanetx.reaction: "MNXR95013" @@ -53777,6 +54811,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Purine metabolism" - annotation: !!omap - bigg.reaction: "NTD7" - kegg.reaction: "R00183" @@ -53793,7 +54828,9 @@ - s_1322: 1 - lower_bound: 0 - upper_bound: 1000 + - gene_reaction_rule: "YGL101W or YBR242W" - subsystem: + - "Purine metabolism" - annotation: !!omap - bigg.reaction: "NTD6" - kegg.reaction: "R02088" @@ -53810,7 +54847,9 @@ - s_1322: 1 - lower_bound: 0 - upper_bound: 1000 + - gene_reaction_rule: "YGL101W or YBR242W" - subsystem: + - "Pyrimidine metabolism" - annotation: !!omap - bigg.reaction: "NTD3" - kegg.reaction: "R01664" @@ -53827,7 +54866,9 @@ - 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sbo: "SBO:0000627" @@ -53999,6 +55051,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, e]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -54010,6 +55063,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_8aonn_e" - sbo: "SBO:0000627" @@ -54021,6 +55075,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_xan_e" - sbo: "SBO:0000627" @@ -54032,6 +55087,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_acald_e" - sbo: "SBO:0000627" @@ -54044,6 +55100,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, m]" - annotation: !!omap - bigg.reaction: "ACALDtm" - metanetx.reaction: "MNXR95212" @@ -54058,6 +55115,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "ACALDt" - 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sbo: "SBO:0000627" @@ -54998,6 +56126,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_sbt__D_e" - sbo: "SBO:0000627" @@ -55010,6 +56139,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "GAM6Pt" - sbo: "SBO:0000655" @@ -55022,6 +56152,7 @@ - lower_bound: -1 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_glc__D_e" - metanetx.reaction: "MNXR138465" @@ -55034,6 +56165,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_man_e" - sbo: "SBO:0000627" @@ -55045,6 +56177,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_rib__D_e" - sbo: "SBO:0000627" @@ -55058,6 +56191,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YDL245C or YEL069C or YJR158W or YNR072W" - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "SBT_Dt" - metanetx.reaction: "MNXR104288" @@ -55071,6 +56205,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_xyl__D_e" - sbo: "SBO:0000627" @@ -55084,6 +56219,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YHR092C" - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "XYLt" - sbo: "SBO:0000655" @@ -55097,6 +56233,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, n]" - annotation: !!omap - bigg.reaction: "DADPtn" - metanetx.reaction: "MNXR97082" @@ -55111,6 +56248,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, n]" - annotation: !!omap - bigg.reaction: "DCDPtn" - metanetx.reaction: "MNXR97182" @@ -55128,6 +56266,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Purine metabolism" - annotation: !!omap - bigg.reaction: "ATPHs" - kegg.reaction: "R00088" @@ -55146,6 +56285,7 @@ - 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kegg.reaction: "R02099" @@ -55321,6 +56472,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YBL042C" - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "DURIt" - metanetx.reaction: "MNXR97819" @@ -55337,7 +56489,9 @@ - s_0794: 1 - lower_bound: 0 - upper_bound: 1000 + - gene_reaction_rule: "YDR196C" - subsystem: + - "Pantothenate and coa biosynthesis" - annotation: !!omap - bigg.reaction: "DPCOAK" - kegg.reaction: "R00130" @@ -55353,6 +56507,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, n]" - annotation: !!omap - bigg.reaction: "DGDPtn" - metanetx.reaction: "MNXR97314" @@ -55367,6 +56522,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, m]" - annotation: !!omap - bigg.reaction: "DHNPTtm" - sbo: "SBO:0000655" @@ -55384,6 +56540,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YDR071C" - subsystem: + - "Arginine and proline metabolism" - annotation: !!omap - bigg.reaction: "DIAT" - metanetx.reaction: "MNXR97455" @@ -55398,6 +56555,7 @@ - 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sbo: "SBO:0000655" @@ -55485,6 +56648,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_dttp_e" - sbo: "SBO:0000627" @@ -55497,6 +56661,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "DTTPt" - metanetx.reaction: "MNXR97810" @@ -55511,6 +56676,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, n]" - annotation: !!omap - bigg.reaction: "DUDPtn" - metanetx.reaction: "MNXR97812" @@ -55525,6 +56691,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, n]" - annotation: !!omap - bigg.reaction: "DUMPtn" - metanetx.reaction: "MNXR97813" @@ -55538,6 +56705,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_epist_e" - sbo: "SBO:0000627" @@ -55550,6 +56718,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, er]" - 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subsystem: + - "Transport [c, g]" - annotation: !!omap - bigg.reaction: "GDPtg" - metanetx.reaction: "MNXR100096" @@ -55934,6 +57133,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, n]" - annotation: !!omap - bigg.reaction: "GDPtn" - metanetx.reaction: "MNXR100096" @@ -55949,6 +57149,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YGL225W" - subsystem: + - "Transport [c, g]" - annotation: !!omap - metanetx.reaction: "MNXR131177" - sbo: "SBO:0000655" @@ -55961,8 +57162,9 @@ - s_0566: 1 - lower_bound: -1000 - upper_bound: 1000 - - gene_reaction_rule: "YBR241C or YGL104C" + - gene_reaction_rule: "YBR241C" - subsystem: + - "Transport [c, v]" - annotation: !!omap - bigg.reaction: "GLCtv" - metanetx.reaction: "MNXR100188" @@ -55976,6 +57178,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_gthox_e" - sbo: "SBO:0000627" @@ -55987,6 +57190,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_gthrd_e" - sbo: "SBO:0000627" @@ -55998,6 +57202,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_glyc_e" - sbo: "SBO:0000627" @@ -56010,6 +57215,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, m]" - annotation: !!omap - bigg.reaction: "GLYC3Ptm" - metanetx.reaction: "MNXR100308" @@ -56024,6 +57230,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_gly_e" - sbo: "SBO:0000627" @@ -56037,6 +57244,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YPR058W" - subsystem: + - "Transport [c, m]" - annotation: !!omap - bigg.reaction: "GLYtm" - metanetx.reaction: "MNXR100371" @@ -56051,6 +57259,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, m]" - annotation: !!omap - bigg.reaction: "GCALDtm" - metanetx.reaction: "MNXR100061" @@ -56065,6 +57274,7 @@ - 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sbo: "SBO:0000627" @@ -56141,6 +57356,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, m]" - annotation: !!omap - bigg.reaction: "GUAtm" - metanetx.reaction: "MNXR100465" @@ -56154,6 +57370,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_gsn_e" - sbo: "SBO:0000627" @@ -56169,6 +57386,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Purine metabolism" - annotation: !!omap - bigg.reaction: "GSNK" - kegg.reaction: "R01228" @@ -56184,6 +57402,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Transport [c, m]" - annotation: !!omap - bigg.reaction: "GSNtm" - metanetx.reaction: "MNXR100433" @@ -56198,6 +57417,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "GSNt" - metanetx.reaction: "MNXR100433" @@ -56212,6 +57432,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "Ht" - metanetx.reaction: "MNXR100765" @@ -56226,6 +57447,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, er]" - annotation: !!omap - bigg.reaction: "Htr" - metanetx.reaction: "MNXR100765" @@ -56240,6 +57462,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, g]" - annotation: !!omap - bigg.reaction: "Htg" - metanetx.reaction: "MNXR100765" @@ -56254,6 +57477,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, lp]" - annotation: !!omap - metanetx.reaction: "MNXR100765" - sbo: "SBO:0000655" @@ -56267,6 +57491,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, n]" - annotation: !!omap - bigg.reaction: "HMR_1095" - metanetx.reaction: "MNXR100765" @@ -56281,6 +57506,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, p]" - annotation: !!omap - bigg.reaction: "Htx" - metanetx.reaction: "MNXR100765" @@ -56295,6 +57521,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, v]" - annotation: !!omap - metanetx.reaction: "MNXR100765" - sbo: "SBO:0000655" @@ -56307,6 +57534,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_h_e" - sbo: "SBO:0000627" @@ -56319,6 +57547,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, er]" - annotation: !!omap - metanetx.reaction: "MNXR124347" - sbo: "SBO:0000655" @@ -56331,6 +57560,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - sbo: "SBO:0000627" - !!omap @@ -56341,7 +57571,9 @@ - s_1288: -1 - lower_bound: -1000 - upper_bound: 1000 + - gene_reaction_rule: "YBR041W" - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "HDCAt" - metanetx.reaction: "MNXR99101" @@ -56355,7 +57587,9 @@ - s_1295: -1 - lower_bound: -1000 - upper_bound: 1000 + - gene_reaction_rule: "YBR041W" - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "HDCEAt" - sbo: "SBO:0000655" @@ -56370,6 +57604,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YBR147W" - subsystem: + - "Transport [c, m]" - annotation: !!omap - metanetx.reaction: "MNXR100649" - sbo: "SBO:0000655" @@ -56389,6 +57624,7 @@ - gene_reaction_rule: "YDL131W or YDL182W" - eccodes: "2.3.3.14" - subsystem: + - "Pyruvate metabolism" - annotation: !!omap - kegg.pathway: - "sce00300" @@ -56409,6 +57645,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, n]" - annotation: !!omap - bigg.reaction: "H2O2tn" - metanetx.reaction: "MNXR98640" @@ -56423,6 +57660,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, m]" - annotation: !!omap - bigg.reaction: "HMGCOAtm" - metanetx.reaction: "MNXR100661" @@ -56436,6 +57674,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_hxan_e" - sbo: "SBO:0000627" @@ -56448,6 +57687,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "HYXNt" - metanetx.reaction: "MNXR100749" @@ -56461,6 +57701,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_id3acald_e" - sbo: "SBO:0000627" @@ -56473,6 +57714,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, m]" - annotation: !!omap - bigg.reaction: "ID3ACALDtm" - metanetx.reaction: "MNXR100791" @@ -56487,6 +57729,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "ID3ACALDt" - metanetx.reaction: "MNXR100791" @@ -56501,6 +57744,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, m]" - annotation: !!omap - bigg.reaction: "IND3ACtm" - metanetx.reaction: "MNXR100833" @@ -56514,6 +57758,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_ins_e" - sbo: "SBO:0000627" @@ -56526,6 +57771,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "INSt" - metanetx.reaction: "MNXR100849" @@ -56540,6 +57786,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, n]" - annotation: !!omap - bigg.reaction: "MINOHPtn" - metanetx.reaction: "MNXR101585" @@ -56557,6 +57804,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Purine metabolism" - annotation: !!omap - bigg.reaction: "INSK" - kegg.reaction: "R01131" @@ -56572,6 +57820,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [er, g]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -56584,6 +57833,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [er, g]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -56596,6 +57846,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [er, g]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -56608,6 +57859,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [er, g]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -56620,6 +57872,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [er, g]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -56632,6 +57885,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [er, g]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -56644,6 +57898,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [er, g]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -56656,6 +57911,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [er, g]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -56668,6 +57924,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [er, g]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -56680,6 +57937,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [er, g]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -56691,6 +57949,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_fe2_e" - sbo: "SBO:0000627" @@ -56702,6 +57961,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_iamac_e" - sbo: "SBO:0000627" @@ -56714,6 +57974,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "IAMOHt" - metanetx.reaction: "MNXR100775" @@ -56728,6 +57989,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, m]" - annotation: !!omap - bigg.reaction: "IAMOHtm" - metanetx.reaction: "MNXR100775" @@ -56741,6 +58003,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_iamoh_e" - sbo: "SBO:0000627" @@ -56752,6 +58015,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_ibutoh_e" - sbo: "SBO:0000627" @@ -56763,6 +58027,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_ibutac_e" - sbo: "SBO:0000627" @@ -56775,6 +58040,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "IBUTOHt" - metanetx.reaction: "MNXR100780" @@ -56789,6 +58055,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, m]" - annotation: !!omap - bigg.reaction: "IBUTOHtm" - metanetx.reaction: "MNXR100780" @@ -56802,6 +58069,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_2mppal_e" - sbo: "SBO:0000627" @@ -56816,6 +58084,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Arginine and proline metabolism" - annotation: !!omap - bigg.reaction: "PHCHGSm" - sbo: "SBO:0000176" @@ -56831,6 +58100,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Glycine, serine and threonine metabolism" - annotation: !!omap - bigg.reaction: "AOBUTDs" - kegg.reaction: "R03758" @@ -56845,6 +58115,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_ala__L_e" - sbo: "SBO:0000627" @@ -56857,6 +58128,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Transport [c, m]" - annotation: !!omap - bigg.reaction: "ALAtmi" - metanetx.reaction: "MNXR95706" @@ -56870,6 +58142,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_abt_e" - sbo: "SBO:0000627" @@ -56882,6 +58155,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "ABTt" - metanetx.reaction: "MNXR95190" @@ -56897,6 +58171,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YDR342C or YHR092C" - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "ARAB_Lt" - metanetx.reaction: "MNXR135734" @@ -56910,6 +58185,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_arab__L_e" - sbo: "SBO:0000627" @@ -56921,6 +58197,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_arg__L_e" - sbo: "SBO:0000627" @@ -56932,6 +58209,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_asn__L_e" - sbo: "SBO:0000627" @@ -56943,6 +58221,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_asp__L_e" - sbo: "SBO:0000627" @@ -56956,6 +58235,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YOR100C" - subsystem: + - "Transport [c, m]" - annotation: !!omap - bigg.reaction: "CRNtim" - 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lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [er, g]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -57447,6 +58766,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [er, g]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -57459,6 +58779,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [er, g]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -57471,6 +58792,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [er, g]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -57483,6 +58805,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [er, g]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -57497,6 +58820,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, p]" - annotation: !!omap - bigg.reaction: "MALOAAtp" - metanetx.reaction: "MNXR101346" @@ -57510,6 +58834,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_malt_e" - metanetx.reaction: "MNXR123950" @@ -57523,6 +58848,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, er]" - annotation: !!omap - bigg.reaction: "MANNANter" - metanetx.reaction: "MNXR101396" @@ -57538,6 +58864,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YDR508C" - subsystem: + - "Transport [c, m]" - annotation: !!omap - bigg.reaction: "METtm" - metanetx.reaction: "MNXR101493" @@ -57553,6 +58880,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Propanoate metabolism" - annotation: !!omap - bigg.reaction: "MGSA" - kegg.reaction: "R01016" @@ -57568,6 +58896,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [er, g]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -57580,6 +58909,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [er, g]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -57592,6 +58922,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [er, g]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -57604,6 +58935,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [er, g]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -57616,6 +58948,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [er, g]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -57628,6 +58961,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [er, g]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -57640,6 +58974,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [er, g]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -57652,6 +58987,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [er, g]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -57664,6 +59000,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [er, g]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -57676,6 +59013,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [er, g]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -57687,6 +59025,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_inost_e" - sbo: "SBO:0000627" @@ -57698,6 +59037,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - sbo: "SBO:0000627" - !!omap @@ -57709,6 +59049,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, er]" - annotation: !!omap - bigg.reaction: "NADPtru" - metanetx.reaction: "MNXR101896" @@ -57723,6 +59064,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, er]" - annotation: !!omap - bigg.reaction: "NADPHtru" - metanetx.reaction: "MNXR101894" @@ -57737,6 +59079,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, m]" - annotation: !!omap - bigg.reaction: "NH4tm" - metanetx.reaction: "MNXR101950" @@ -57751,6 +59094,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, n]" - annotation: !!omap - metanetx.reaction: "MNXR101918" - sbo: "SBO:0000655" @@ -57763,6 +59107,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_nac_e" - sbo: "SBO:0000627" @@ -57774,6 +59119,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_nmn_e" - sbo: "SBO:0000627" @@ -57786,6 +59132,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, n]" - annotation: !!omap - bigg.reaction: "NMNtn" - metanetx.reaction: "MNXR101972" @@ -57800,6 +59147,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, p]" - annotation: !!omap - metanetx.reaction: "MNXR101972" - sbo: "SBO:0000655" @@ -57813,6 +59161,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "NMNP" - metanetx.reaction: "MNXR101972" @@ -57830,6 +59179,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Purine metabolism" - annotation: !!omap - bigg.reaction: "NDP4" - metanetx.reaction: "MNXR101929" @@ -57847,6 +59197,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Purine metabolism" - annotation: !!omap - bigg.reaction: "NTP4" - metanetx.reaction: "MNXR102044" @@ -57862,6 +59213,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YOR100C" - subsystem: + - "Transport [c, m]" - annotation: !!omap - bigg.reaction: "ACRNtm" - metanetx.reaction: "MNXR95412" @@ -57876,6 +59228,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, er]" - annotation: !!omap - bigg.reaction: "O2ter" - metanetx.reaction: "MNXR102090" @@ -57890,6 +59243,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, m]" - annotation: !!omap - bigg.reaction: "O2tm" - metanetx.reaction: "MNXR102090" @@ -57904,6 +59258,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "O2t" - metanetx.reaction: "MNXR102090" @@ -57918,6 +59273,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, p]" - annotation: !!omap - bigg.reaction: "O2tp" - metanetx.reaction: "MNXR102090" @@ -57931,7 +59287,9 @@ - s_1450: -1 - lower_bound: -1000 - upper_bound: 1000 + - gene_reaction_rule: "YBR041W" - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "OCDCAt" - metanetx.reaction: "MNXR99109" @@ -57945,6 +59303,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_octa_e" - sbo: "SBO:0000627" @@ -57956,6 +59315,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_orn_e" - sbo: "SBO:0000627" @@ -57968,6 +59328,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "OAAt" - metanetx.reaction: "MNXR102100" @@ -57981,6 +59342,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_oaa_e" - kegg.reaction: "R00363" @@ -57996,6 +59358,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YJL212C" - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "GTHOXti" - metanetx.reaction: "MNXR100443" @@ -58010,6 +59373,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, p]" - annotation: !!omap - bigg.reaction: "TRDOXtp" - metanetx.reaction: "MNXR104921" @@ -58023,6 +59387,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_o2_e" - sbo: "SBO:0000627" @@ -58034,6 +59399,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_hdca_e" - sbo: "SBO:0000627" @@ -58045,6 +59411,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_hdcea_e" - sbo: "SBO:0000627" @@ -58057,6 +59424,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, er]" - annotation: !!omap - bigg.reaction: "PMTCOAFABP1tc" - metanetx.reaction: "MNXR103046" @@ -58071,6 +59439,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, m]" - annotation: !!omap - bigg.reaction: "PAN4Ptm" - metanetx.reaction: "MNXR102344" @@ -58088,6 +59457,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Pantothenate and coa biosynthesis" - annotation: !!omap - bigg.reaction: "PTPATim" - kegg.reaction: "R03035" @@ -58103,6 +59473,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "PAPt" - metanetx.reaction: "MNXR102382" @@ -58116,6 +59487,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_pectin_e" - sbo: "SBO:0000627" @@ -58127,6 +59499,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_pheac_e" - sbo: "SBO:0000627" @@ -58138,6 +59511,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_pacald_e" - sbo: "SBO:0000627" @@ -58150,6 +59524,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "PACALDt" - metanetx.reaction: "MNXR102312" @@ -58164,6 +59539,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, m]" - annotation: !!omap - bigg.reaction: "PACALDtm" - metanetx.reaction: "MNXR102312" @@ -58178,6 +59554,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Transport [c, m]" - annotation: !!omap - metanetx.reaction: "MNXR102637" - sbo: "SBO:0000655" @@ -58190,6 +59567,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_pi_e" - sbo: "SBO:0000627" @@ -58203,6 +59581,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YNR013C" - subsystem: + - "Transport [c, v]" - annotation: !!omap - metanetx.reaction: "MNXR102871" - sbo: "SBO:0000655" @@ -58215,6 +59594,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_k_e" - sbo: "SBO:0000627" @@ -58227,6 +59607,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, m]" - annotation: !!omap - bigg.reaction: "PPPG9tm" - metanetx.reaction: "MNXR103127" @@ -58241,6 +59622,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, m]" - annotation: !!omap - bigg.reaction: "PRPPtm" - metanetx.reaction: "MNXR103216" @@ -58254,6 +59636,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_ptrc_e" - sbo: "SBO:0000627" @@ -58270,6 +59653,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YNR027W" - subsystem: + - "Vitamin b6 metabolism" - annotation: !!omap - bigg.reaction: "PYDXK" - kegg.reaction: "R00174" @@ -58287,7 +59671,9 @@ - s_1395: 1 - lower_bound: 0 - upper_bound: 1000 + - gene_reaction_rule: "YNR027W" - subsystem: + - "Vitamin b6 metabolism" - annotation: !!omap - bigg.reaction: "PYDAMK" - kegg.reaction: "R02493" @@ -58305,6 +59691,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Vitamin b6 metabolism" - annotation: !!omap - bigg.reaction: "HYPOE" - kegg.reaction: "R02494" @@ -58319,6 +59706,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_pydxn_e" - sbo: "SBO:0000627" @@ -58336,6 +59724,7 @@ - gene_reaction_rule: "YEL029C" - eccodes: "2.7.1.35" - subsystem: + - "Vitamin b6 metabolism" - annotation: !!omap - bigg.reaction: "PYDXNK" - kegg.pathway: "sce00750" @@ -58354,6 +59743,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Riboflavin metabolism" - annotation: !!omap - bigg.reaction: "PMDPHT" - kegg.reaction: "R07280" @@ -58371,6 +59761,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Pyrimidine metabolism" - annotation: !!omap - bigg.reaction: "PYNP2r" - kegg.reaction: "R01876" @@ -58386,6 +59777,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, m]" - annotation: !!omap - bigg.reaction: "PPItm" - metanetx.reaction: "MNXR103112" @@ -58399,6 +59791,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_pyr_e" - sbo: "SBO:0000627" @@ -58414,6 +59807,7 @@ - upper_bound: 1000 - gene_reaction_rule: "(YGL080W and YGR243W) or (YGL080W and YHR162W)" - subsystem: + - "Transport [c, m]" - annotation: !!omap - bigg.reaction: "PYRt2m" - metanetx.reaction: "MNXR103385" @@ -58429,6 +59823,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, m]" - 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lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, m]" - annotation: !!omap - bigg.reaction: "AHCYStm" - metanetx.reaction: "MNXR95626" @@ -58524,6 +59925,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_amet_e" - sbo: "SBO:0000627" @@ -58535,6 +59937,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_mmet_e" - sbo: "SBO:0000627" @@ -58548,6 +59951,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YDR508C" - subsystem: + - "Transport [c, m]" - annotation: !!omap - bigg.reaction: "r1435" - metanetx.reaction: "MNXR104354" @@ -58561,6 +59965,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_g3pc_e" - sbo: "SBO:0000627" @@ -58572,6 +59977,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_na1_e" - 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lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_thmmp_e" - sbo: "SBO:0000627" @@ -58816,6 +60240,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Thiamine metabolism" - annotation: !!omap - bigg.reaction: "TMPK" - kegg.reaction: "R00617" @@ -58841,6 +60266,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Thiamine metabolism" - annotation: !!omap - bigg.reaction: "THZPSN2_SC" - metanetx.reaction: "MNXR104860" @@ -58865,6 +60291,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Thiamine metabolism" - annotation: !!omap - bigg.reaction: "THZPSN1_SC" - metanetx.reaction: "MNXR104859" @@ -58880,6 +60307,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YDR508C" - subsystem: + - "Transport [c, m]" - annotation: !!omap - bigg.reaction: "thr_mt" - metanetx.reaction: "MNXR104852" @@ -58893,6 +60321,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_thymd_e" - sbo: "SBO:0000627" @@ -58908,6 +60337,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Pyrimidine metabolism" - annotation: !!omap - bigg.reaction: "TMDK1" - kegg.reaction: "R01567" @@ -58923,6 +60353,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "THYMDt1" - metanetx.reaction: "MNXR104821" @@ -58940,6 +60371,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YGR289C" - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "TREt2" - metanetx.reaction: "MNXR104932" @@ -58955,6 +60387,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, v]" - annotation: !!omap - metanetx.reaction: "MNXR104933" - sbo: "SBO:0000655" @@ -58968,6 +60401,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Transport [c, m]" - annotation: !!omap - metanetx.reaction: "MNXR104949" - sbo: "SBO:0000655" @@ -58980,6 +60414,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_ind3eth_e" - sbo: "SBO:0000627" @@ -58992,6 +60427,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "IND3ETHt" - metanetx.reaction: "MNXR100834" @@ -59006,6 +60442,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, m]" - annotation: !!omap - bigg.reaction: "IND3ETHtm" - metanetx.reaction: "MNXR100834" @@ -59020,6 +60457,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Transport [c, m]" - annotation: !!omap - bigg.reaction: "r1078" - metanetx.reaction: "MNXR105002" @@ -59034,6 +60472,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, p]" - annotation: !!omap - metanetx.reaction: "MNXR105002" - sbo: "SBO:0000655" @@ -59047,6 +60486,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, n]" - annotation: !!omap - bigg.reaction: "UMPtn" - metanetx.reaction: "MNXR105127" @@ -59060,6 +60500,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_ura_e" - sbo: "SBO:0000627" @@ -59071,6 +60512,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_urea_e" - sbo: "SBO:0000627" @@ -59082,6 +60524,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_uri_e" - sbo: "SBO:0000627" @@ -59094,6 +60537,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, m]" - annotation: !!omap - bigg.reaction: "VALt5m" - metanetx.reaction: "MNXR105190" @@ -59109,6 +60553,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YLL052C or YPR192W" - subsystem: + - "Transport [c, er]" - annotation: !!omap - bigg.reaction: "H2Oter" - metanetx.reaction: "MNXR98641" @@ -59123,6 +60568,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, g]" - annotation: !!omap - bigg.reaction: "H2Otg" - metanetx.reaction: "MNXR98641" @@ -59137,6 +60583,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, m]" - annotation: !!omap - bigg.reaction: "H2Otm" - metanetx.reaction: "MNXR98641" @@ -59151,6 +60598,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, n]" - annotation: !!omap - bigg.reaction: "H2Otn" - metanetx.reaction: "MNXR98641" @@ -59165,6 +60613,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, p]" - annotation: !!omap - bigg.reaction: "H2Otp" - metanetx.reaction: "MNXR98641" @@ -59179,6 +60628,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, v]" - annotation: !!omap - bigg.reaction: "H2Otv" - metanetx.reaction: "MNXR98641" @@ -59192,6 +60642,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_h2o_e" - sbo: "SBO:0000627" @@ -59204,6 +60655,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "XANt" - metanetx.reaction: "MNXR105226" @@ -59217,6 +60669,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_xtsn_e" - sbo: "SBO:0000627" @@ -59229,6 +60682,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "XTSNtr" - metanetx.reaction: "MNXR105247" @@ -59242,6 +60696,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_xylt_e" - sbo: "SBO:0000627" @@ -59255,6 +60710,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YDL245C or YLL043W" - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "XYLTt" - metanetx.reaction: "MNXR105264" @@ -59268,6 +60724,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_zymst_e" - sbo: "SBO:0000627" @@ -59281,6 +60738,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YIL013C or YOR011W" - subsystem: + - "Transport [c, ce]" - annotation: !!omap - metanetx.reaction: "MNXR105285" - sbo: "SBO:0000655" @@ -59295,6 +60753,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Growth" - annotation: !!omap - pubmed: "18687109" - sbo: "SBO:0000395" @@ -59308,6 +60767,7 @@ - upper_bound: 1000 - objective_coefficient: 1 - subsystem: + - "Exchange reaction" - annotation: !!omap - metanetx.reaction: "MNXR137261" - sbo: "SBO:0000632" @@ -59326,6 +60786,7 @@ - gene_reaction_rule: "YJL060W" - eccodes: "2.6.1.7" - subsystem: + - "Tryptophan metabolism" - annotation: !!omap - kegg.pathway: "sce00380" - kegg.reaction: "R01959" @@ -59346,6 +60807,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Tryptophan metabolism" - annotation: !!omap - kegg.reaction: "R03687" - metanetx.reaction: "MNXR108341" @@ -59363,6 +60825,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Tryptophan metabolism" - annotation: !!omap - kegg.reaction: "R04293" - metanetx.reaction: "MNXR103396" @@ -59383,6 +60846,7 @@ - gene_reaction_rule: "YBR145W or YOL086C" - eccodes: "1.1.1.1" - subsystem: + - "Glycolysis / gluconeogenesis" - annotation: !!omap - bigg.reaction: "ALCD2ir" - kegg.pathway: @@ -59411,6 +60875,7 @@ - gene_reaction_rule: "YMR110C or YMR170C or YER073W or YOR374W" - eccodes: "1.2.1.3" - subsystem: + - "Glycolysis / gluconeogenesis" - annotation: !!omap - kegg.pathway: - "sce00010" @@ -59438,6 +60903,7 @@ - "2.6.1.58" - "2.6.1.7" - subsystem: + - "Phenylalanine, tyrosine and tryptophan biosynthesis" - annotation: !!omap - kegg.pathway: - "sce00350" @@ -59467,6 +60933,7 @@ - "2.6.1.57" - "2.6.1.7" - subsystem: + - "Phenylalanine, tyrosine and tryptophan biosynthesis" - annotation: !!omap - bigg.reaction: "araphe3" - kegg.pathway: @@ -59497,6 +60964,7 @@ - "2.6.1.57" - "2.6.1.7" - subsystem: + - "Phenylalanine, tyrosine and tryptophan biosynthesis" - annotation: !!omap - kegg.pathway: - "sce00350" @@ -59520,6 +60988,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, lp]" - annotation: !!omap - kegg.reaction: "R00197" - metanetx.reaction: "MNXR138960" @@ -59539,6 +61008,7 @@ - gene_reaction_rule: "YKR043C" - eccodes: "3.1.3.37" - subsystem: + - "Glycolysis / gluconeogenesis" - annotation: !!omap - kegg.pathway: - "sce00010" @@ -59563,6 +61033,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Transport [c, m]" - annotation: !!omap - bigg.reaction: "Htm" - metanetx.reaction: "MNXR100765" @@ -59583,6 +61054,7 @@ - gene_reaction_rule: "YDL066W" - eccodes: "1.1.1.42" - subsystem: + - "Citrate cycle (TCA cycle)" - annotation: !!omap - bigg.reaction: "ICDHym" - kegg.pathway: @@ -59613,6 +61085,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YOR222W or YPL134C" - subsystem: + - "Transport [c, m]" - annotation: !!omap - bigg.reaction: "AKGMALtm" - metanetx.reaction: "MNXR95659" @@ -59627,6 +61100,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - sbo: "SBO:0000627" - !!omap @@ -59638,6 +61112,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, e]" - annotation: !!omap - metanetx.reaction: "MNXR137169" - sbo: "SBO:0000655" @@ -59650,6 +61125,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - sbo: "SBO:0000627" - !!omap @@ -59661,6 +61137,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, e]" - annotation: !!omap - metanetx.reaction: "MNXR97951" - sbo: "SBO:0000655" @@ -59683,6 +61160,7 @@ - gene_reaction_rule: "YKL182W and YPL231W" - eccodes: "2.3.1.86" - subsystem: + - "Fatty acid biosynthesis" - annotation: !!omap - kegg.pathway: - "sce00061" @@ -59708,6 +61186,7 @@ - gene_reaction_rule: "YKL182W and YPL231W" - eccodes: "2.3.1.86" - subsystem: + - "Fatty acid biosynthesis" - annotation: !!omap - kegg.pathway: - "sce00061" @@ -59730,6 +61209,7 @@ - gene_reaction_rule: "YER061C and YKL192C" - eccodes: "2.3.1.41" - subsystem: + - "Fatty acid biosynthesis" - annotation: !!omap - bigg.reaction: "3OAS40_m" - kegg.pathway: @@ -59755,6 +61235,7 @@ - gene_reaction_rule: "YER061C and YKL192C" - eccodes: "2.3.1.41" - subsystem: + - "Fatty acid biosynthesis" - annotation: !!omap - kegg.pathway: - "sce00061" @@ -59779,6 +61260,7 @@ - gene_reaction_rule: "YER061C and YKL192C" - eccodes: "2.3.1.41" - subsystem: + - "Fatty acid biosynthesis" - annotation: !!omap - kegg.pathway: - "sce00061" @@ -59802,6 +61284,7 @@ - gene_reaction_rule: "YKL055C" - eccodes: "1.1.1.100" - subsystem: + - "Fatty acid biosynthesis" - annotation: !!omap - bigg.reaction: "3OAR40_m" - kegg.pathway: @@ -59827,6 +61310,7 @@ - gene_reaction_rule: "YKL055C" - eccodes: "1.1.1.100" - subsystem: + - "Fatty acid biosynthesis" - annotation: !!omap - bigg.reaction: "3OAR60_m" - kegg.pathway: @@ -59852,6 +61336,7 @@ - gene_reaction_rule: "YKL055C" - eccodes: "1.1.1.100" - subsystem: + - "Fatty acid biosynthesis" - annotation: !!omap - kegg.pathway: - "sce00061" @@ -59875,6 +61360,7 @@ - gene_reaction_rule: "YHR067W" - eccodes: "4.2.1.-" - subsystem: + - "Fatty acid biosynthesis" - annotation: !!omap - pubmed: "15387819" - sbo: "SBO:0000176" @@ -59891,6 +61377,7 @@ - gene_reaction_rule: "YHR067W" - eccodes: "4.2.1.-" - subsystem: + - "Fatty acid biosynthesis" - annotation: !!omap - bigg.reaction: "3HAD61_m" - pubmed: "15387819" @@ -59908,6 +61395,7 @@ - gene_reaction_rule: "YHR067W" - eccodes: "4.2.1.-" - subsystem: + - "Fatty acid biosynthesis" - annotation: !!omap - metanetx.reaction: "MNXR137214" - pubmed: "15387819" @@ -59927,6 +61415,7 @@ - gene_reaction_rule: "YBR026C" - eccodes: "1.3.1.104" - subsystem: + - "Biosynthesis of unsaturated fatty acids" - annotation: !!omap - kegg.pathway: - "sce00062" @@ -59948,6 +61437,7 @@ - gene_reaction_rule: "YBR026C" - eccodes: "1.3.1.104" - subsystem: + - "Biosynthesis of unsaturated fatty acids" - annotation: !!omap - kegg.pathway: - "sce00062" @@ -59969,6 +61459,7 @@ - gene_reaction_rule: "YBR026C" - eccodes: "1.3.1.104" - subsystem: + - "Biosynthesis of unsaturated fatty acids" - annotation: !!omap - kegg.pathway: - "sce00062" @@ -59991,6 +61482,7 @@ - gene_reaction_rule: "YJL196C" - eccodes: "2.3.1.199" - subsystem: + - "Biosynthesis of unsaturated fatty acids" - annotation: !!omap - kegg.pathway: - "sce00062" @@ -60016,6 +61508,7 @@ - gene_reaction_rule: "YJL196C" - eccodes: "2.3.1.199" - subsystem: + - "Biosynthesis of unsaturated fatty acids" - annotation: !!omap - kegg.pathway: - "sce00062" @@ -60041,6 +61534,7 @@ - gene_reaction_rule: "YCR034W" - eccodes: "2.3.1.199" - subsystem: + - "Biosynthesis of unsaturated fatty acids" - annotation: !!omap - kegg.pathway: - "sce00062" @@ -60067,6 +61561,7 @@ - gene_reaction_rule: "YCR034W or YLR372W" - eccodes: "2.3.1.199" - subsystem: + - "Biosynthesis of unsaturated fatty acids" - annotation: !!omap - kegg.pathway: - "sce00062" @@ -60092,6 +61587,7 @@ - gene_reaction_rule: "YCR034W or YLR372W" - eccodes: "2.3.1.199" - subsystem: + - "Biosynthesis of unsaturated fatty acids" - annotation: !!omap - kegg.pathway: - "sce00062" @@ -60116,6 +61612,7 @@ - gene_reaction_rule: "YCR034W or YLR372W" - eccodes: "2.3.1.199" - subsystem: + - "Biosynthesis of unsaturated fatty acids" - annotation: !!omap - kegg.pathway: - "sce00062" @@ -60140,6 +61637,7 @@ - gene_reaction_rule: "YLR372W" - eccodes: "2.3.1.199" - subsystem: + - "Biosynthesis of unsaturated fatty acids" - annotation: !!omap - kegg.pathway: - "sce00062" @@ -60164,6 +61662,7 @@ - gene_reaction_rule: "YBR159W" - eccodes: "1.1.1.330" - subsystem: + - "Biosynthesis of unsaturated fatty acids" - annotation: !!omap - kegg.pathway: - "sce00062" @@ -60187,6 +61686,7 @@ - gene_reaction_rule: "YBR159W" - eccodes: "1.1.1.330" - subsystem: + - "Biosynthesis of unsaturated fatty acids" - annotation: !!omap - kegg.pathway: - "sce00062" @@ -60210,6 +61710,7 @@ - gene_reaction_rule: "YBR159W" - eccodes: "1.1.1.330" - subsystem: + - "Biosynthesis of unsaturated fatty acids" - annotation: !!omap - kegg.pathway: - "sce00062" @@ -60235,6 +61736,7 @@ - gene_reaction_rule: "YBR159W" - eccodes: "1.1.1.330" - subsystem: + - "Biosynthesis of unsaturated fatty acids" - annotation: !!omap - kegg.pathway: - "sce00062" @@ -60259,6 +61761,7 @@ - gene_reaction_rule: "YBR159W" - eccodes: "1.1.1.330" - subsystem: + - "Biosynthesis of unsaturated fatty acids" - annotation: !!omap - kegg.pathway: - "sce00062" @@ -60283,6 +61786,7 @@ - gene_reaction_rule: "YBR159W" - eccodes: "1.1.1.330" - subsystem: + - "Biosynthesis of unsaturated fatty acids" - annotation: !!omap - kegg.pathway: - "sce00062" @@ -60307,6 +61811,7 @@ - gene_reaction_rule: "YBR159W" - eccodes: "1.1.1.330" - subsystem: + - "Biosynthesis of unsaturated fatty acids" - annotation: !!omap - kegg.pathway: - "sce00062" @@ -60328,6 +61833,7 @@ - gene_reaction_rule: "YJL097W" - eccodes: "4.2.1.134" - subsystem: + - "Biosynthesis of unsaturated fatty acids" - annotation: !!omap - kegg.pathway: - "sce00062" @@ -60351,6 +61857,7 @@ - gene_reaction_rule: "YJL097W" - eccodes: "4.2.1.134" - subsystem: + - "Biosynthesis of unsaturated fatty acids" - annotation: !!omap - kegg.pathway: - "sce00062" @@ -60372,6 +61879,7 @@ - gene_reaction_rule: "YJL097W" - eccodes: "4.2.1.134" - subsystem: + - "Biosynthesis of unsaturated fatty acids" - annotation: !!omap - kegg.pathway: - "sce00062" @@ -60395,6 +61903,7 @@ - gene_reaction_rule: "YJL097W" - eccodes: "4.2.1.134" - subsystem: + - "Biosynthesis of unsaturated fatty acids" - annotation: !!omap - kegg.pathway: - "sce00062" @@ -60416,6 +61925,7 @@ - gene_reaction_rule: "YJL097W" - eccodes: "4.2.1.134" - subsystem: + - "Biosynthesis of unsaturated fatty acids" - annotation: !!omap - kegg.pathway: - "sce00062" @@ -60437,6 +61947,7 @@ - gene_reaction_rule: "YJL097W" - eccodes: "4.2.1.134" - subsystem: + - "Biosynthesis of unsaturated fatty acids" - annotation: !!omap - kegg.pathway: - "sce00062" @@ -60459,6 +61970,7 @@ - gene_reaction_rule: "YJL097W" - eccodes: "4.2.1.134" - subsystem: + - "Biosynthesis of unsaturated fatty acids" - annotation: !!omap - kegg.pathway: - "sce00062" @@ -60482,6 +61994,7 @@ - gene_reaction_rule: "YDL015C" - eccodes: "1.3.1.93" - subsystem: + - "Biosynthesis of unsaturated fatty acids" - annotation: !!omap - kegg.pathway: - "sce00062" @@ -60507,6 +62020,7 @@ - gene_reaction_rule: "YDL015C" - eccodes: "1.3.1.93" - subsystem: + - "Biosynthesis of unsaturated fatty acids" - annotation: !!omap - kegg.pathway: - "sce00062" @@ -60530,6 +62044,7 @@ - gene_reaction_rule: "YDL015C" - eccodes: "1.3.1.93" - subsystem: + - "Biosynthesis of unsaturated fatty acids" - annotation: !!omap - kegg.pathway: - "sce00062" @@ -60555,6 +62070,7 @@ - gene_reaction_rule: "YDL015C" - eccodes: "1.3.1.93" - subsystem: + - "Biosynthesis of unsaturated fatty acids" - annotation: !!omap - kegg.pathway: - "sce00062" @@ -60578,6 +62094,7 @@ - gene_reaction_rule: "YDL015C" - eccodes: "1.3.1.93" - subsystem: + - "Biosynthesis of unsaturated fatty acids" - annotation: !!omap - kegg.pathway: - "sce00062" @@ -60601,6 +62118,7 @@ - gene_reaction_rule: "YDL015C" - eccodes: "1.3.1.93" - subsystem: + - "Biosynthesis of unsaturated fatty acids" - annotation: !!omap - kegg.pathway: - "sce00062" @@ -60624,6 +62142,7 @@ - gene_reaction_rule: "YDL015C" - eccodes: "1.3.1.93" - subsystem: + - "Biosynthesis of unsaturated fatty acids" - annotation: !!omap - kegg.pathway: - "sce00062" @@ -60650,6 +62169,7 @@ - gene_reaction_rule: "YGL055W" - eccodes: "1.14.19.1" - subsystem: + - "Biosynthesis of unsaturated fatty acids" - annotation: !!omap - kegg.pathway: - "sce01040" @@ -60673,6 +62193,7 @@ - gene_reaction_rule: "YGL055W" - eccodes: "1.14.19.1" - subsystem: + - "Biosynthesis of unsaturated fatty acids" - annotation: !!omap - kegg.pathway: - "sce01040" @@ -60689,6 +62210,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "OCTAt" - metanetx.reaction: "MNXR99126" @@ -60703,6 +62225,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "DCATDc" - metanetx.reaction: "MNXR135772" @@ -60716,7 +62239,9 @@ - s_1067: -1 - lower_bound: -1000 - upper_bound: 1000 + - gene_reaction_rule: "YBR041W" - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "r2444" - metanetx.reaction: "MNXR135773" @@ -60730,6 +62255,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_but_e" - sbo: "SBO:0000627" @@ -60741,6 +62267,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_hxa_e" - sbo: "SBO:0000627" @@ -60752,6 +62279,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_ocdcea_e" - sbo: "SBO:0000627" @@ -60765,6 +62293,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YNL065W" - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "BUTt" - sbo: "SBO:0000655" @@ -60779,6 +62308,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YNL065W" - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "HXAt3" - metanetx.reaction: "MNXR100750" @@ -60792,7 +62322,9 @@ - s_2826: -1 - lower_bound: -1000 - upper_bound: 1000 + - gene_reaction_rule: "YBR041W" - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "OCDCEAt" - metanetx.reaction: "MNXR99110" @@ -60806,6 +62338,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_ttdca_e" - sbo: "SBO:0000627" @@ -60824,6 +62357,7 @@ - gene_reaction_rule: "YOR317W" - eccodes: "6.2.1.3" - subsystem: + - "Fatty acid biosynthesis" - annotation: !!omap - kegg.pathway: - "sce00061" @@ -60849,6 +62383,7 @@ - gene_reaction_rule: "YMR246W or YOR317W" - eccodes: "6.2.1.3" - subsystem: + - "Fatty acid biosynthesis" - annotation: !!omap - kegg.pathway: - "sce00061" @@ -60874,6 +62409,7 @@ - gene_reaction_rule: "YMR246W or YOR317W" - eccodes: "6.2.1.3" - subsystem: + - "Fatty acid biosynthesis" - annotation: !!omap - kegg.pathway: - "sce00061" @@ -60900,6 +62436,7 @@ - gene_reaction_rule: "YMR246W or YOR317W" - eccodes: "6.2.1.3" - subsystem: + - "Fatty acid biosynthesis" - annotation: !!omap - kegg.pathway: - "sce00061" @@ -60925,6 +62462,7 @@ - gene_reaction_rule: "YMR246W or YOR317W" - eccodes: "6.2.1.3" - subsystem: + - "Fatty acid biosynthesis" - annotation: !!omap - kegg.pathway: - "sce00061" @@ -60950,6 +62488,7 @@ - gene_reaction_rule: "YMR246W or YOR317W" - eccodes: "6.2.1.3" - subsystem: + - "Fatty acid biosynthesis" - annotation: !!omap - kegg.pathway: - "sce00061" @@ -60975,6 +62514,7 @@ - gene_reaction_rule: "YOR317W" - eccodes: "6.2.1.3" - subsystem: + - "Fatty acid biosynthesis" - annotation: !!omap - kegg.pathway: - "sce00061" @@ -61000,6 +62540,7 @@ - gene_reaction_rule: "YMR246W or YOR317W" - eccodes: "6.2.1.3" - subsystem: + - "Fatty acid biosynthesis" - annotation: !!omap - kegg.pathway: - "sce00061" @@ -61025,6 +62566,7 @@ - gene_reaction_rule: "YMR246W or YOR317W" - eccodes: "6.2.1.3" - subsystem: + - "Fatty acid biosynthesis" - annotation: !!omap - kegg.pathway: - "sce00061" @@ -61051,6 +62593,7 @@ - gene_reaction_rule: "YMR246W or YOR317W" - eccodes: "6.2.1.3" - subsystem: + - "Fatty acid biosynthesis" - annotation: !!omap - kegg.pathway: - "sce00061" @@ -61076,6 +62619,7 @@ - gene_reaction_rule: "YMR246W or YOR317W" - eccodes: "6.2.1.3" - subsystem: + - "Fatty acid biosynthesis" - annotation: !!omap - kegg.pathway: - "sce00061" @@ -61101,6 +62645,7 @@ - gene_reaction_rule: "YMR246W or YOR317W" - eccodes: "6.2.1.3" - subsystem: + - "Fatty acid biosynthesis" - annotation: !!omap - kegg.pathway: - "sce00061" @@ -61126,6 +62671,7 @@ - gene_reaction_rule: "YER015W" - eccodes: "6.2.1.3" - subsystem: + - "Fatty acid biosynthesis" - annotation: !!omap - bigg.reaction: "FACOAL161p" - kegg.pathway: @@ -61152,6 +62698,7 @@ - gene_reaction_rule: "YER015W" - eccodes: "6.2.1.3" - subsystem: + - "Fatty acid biosynthesis" - annotation: !!omap - kegg.pathway: - "sce00061" @@ -61177,6 +62724,7 @@ - gene_reaction_rule: "YER015W" - eccodes: "6.2.1.3" - subsystem: + - "Fatty acid biosynthesis" - annotation: !!omap - kegg.pathway: - "sce00061" @@ -61202,6 +62750,7 @@ - gene_reaction_rule: "YIL009W" - eccodes: "6.2.1.3" - subsystem: + - "Fatty acid biosynthesis" - annotation: !!omap - kegg.pathway: - "sce00061" @@ -61226,6 +62775,7 @@ - gene_reaction_rule: "YIL009W" - eccodes: "6.2.1.3" - subsystem: + - "Fatty acid biosynthesis" - annotation: !!omap - kegg.pathway: - "sce00061" @@ -61250,6 +62800,7 @@ - gene_reaction_rule: "YIL009W" - eccodes: "6.2.1.3" - subsystem: + - "Fatty acid biosynthesis" - annotation: !!omap - kegg.pathway: - "sce00061" @@ -61275,6 +62826,7 @@ - gene_reaction_rule: "YIL009W" - eccodes: "6.2.1.3" - subsystem: + - "Fatty acid biosynthesis" - annotation: !!omap - kegg.pathway: - "sce00061" @@ -61299,6 +62851,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YBR041W" - subsystem: + - "Fatty acid biosynthesis" - annotation: !!omap - pubmed: "22345606" - sbo: "SBO:0000176" @@ -61317,6 +62870,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YBR041W" - subsystem: + - "Fatty acid biosynthesis" - annotation: !!omap - metanetx.reaction: "MNXR126665" - pubmed: "22345606" @@ -61336,6 +62890,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YBR041W" - subsystem: + - "Fatty acid biosynthesis" - annotation: !!omap - metanetx.reaction: "MNXR128076" - pubmed: "22345606" @@ -61355,6 +62910,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YBR041W" - subsystem: + - "Fatty acid biosynthesis" - annotation: !!omap - pubmed: "22345606" - sbo: "SBO:0000176" @@ -61373,6 +62929,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YBR041W" - subsystem: + - "Fatty acid biosynthesis" - annotation: !!omap - metanetx.reaction: "MNXR126665" - pubmed: "22345606" @@ -61392,6 +62949,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YBR041W" - subsystem: + - "Fatty acid biosynthesis" - annotation: !!omap - metanetx.reaction: "MNXR128076" - pubmed: "22345606" @@ -61412,6 +62970,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YKL188C and YPL147W" - subsystem: + - "Transport [c, p]" - annotation: !!omap - kegg.pathway: - "sce02010" @@ -61434,6 +62993,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YKL188C and YPL147W" - subsystem: + - "Transport [c, p]" - annotation: !!omap - kegg.pathway: - "sce02010" @@ -61456,6 +63016,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YKL188C and YPL147W" - subsystem: + - "Transport [c, p]" - annotation: !!omap - bigg.reaction: "FA160COAabcp_1" - kegg.pathway: @@ -61480,6 +63041,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YKL188C and YPL147W" - subsystem: + - "Transport [c, p]" - annotation: !!omap - kegg.pathway: - "sce02010" @@ -61502,6 +63064,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YKL188C and YPL147W" - subsystem: + - "Transport [c, p]" - annotation: !!omap - bigg.reaction: "STCOATxc" - kegg.pathway: @@ -61526,6 +63089,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YKL188C and YPL147W" - subsystem: + - "Transport [c, p]" - annotation: !!omap - kegg.pathway: - "sce02010" @@ -61548,6 +63112,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YKL188C and YPL147W" - subsystem: + - "Transport [c, p]" - annotation: !!omap - kegg.pathway: - "sce02010" @@ -61570,6 +63135,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YKL188C and YPL147W" - subsystem: + - "Transport [c, p]" - annotation: !!omap - bigg.reaction: "DOCOSCOAtxc" - kegg.pathway: @@ -61593,6 +63159,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YKL188C and YPL147W" - subsystem: + - "Transport [c, p]" - annotation: !!omap - bigg.reaction: "LGNCCOAtcx_1" - kegg.pathway: @@ -61616,6 +63183,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YKL188C and YPL147W" - subsystem: + - "Transport [c, p]" - annotation: !!omap - kegg.pathway: - "sce02010" @@ -61632,6 +63200,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, p]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -61644,6 +63213,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, p]" - annotation: !!omap - bigg.reaction: "HXAt2" - metanetx.reaction: "MNXR100750" @@ -61659,6 +63229,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YKL188C and YPL147W" - subsystem: + - "Transport [c, p]" - annotation: !!omap - metanetx.reaction: "MNXR99110" - sbo: "SBO:0000655" @@ -61677,6 +63248,7 @@ - gene_reaction_rule: "YJR019C" - eccodes: "3.1.2.2" - subsystem: + - "Biosynthesis of unsaturated fatty acids" - annotation: !!omap - kegg.pathway: - "sce00062" @@ -61699,6 +63271,7 @@ - gene_reaction_rule: "YJR019C" - eccodes: "3.1.2.2" - subsystem: + - "Biosynthesis of unsaturated fatty acids" - annotation: !!omap - bigg.reaction: "HXCOAx" - kegg.pathway: @@ -61723,6 +63296,7 @@ - gene_reaction_rule: "YJR019C" - eccodes: "3.1.2.2" - subsystem: + - "Biosynthesis of unsaturated fatty acids" - annotation: !!omap - kegg.pathway: - "sce00062" @@ -61746,6 +63320,7 @@ - gene_reaction_rule: "YJR019C" - eccodes: "3.1.2.2" - subsystem: + - "Biosynthesis of unsaturated fatty acids" - annotation: !!omap - kegg.pathway: - "sce00062" @@ -61769,6 +63344,7 @@ - gene_reaction_rule: "YGL205W" - eccodes: "1.3.3.6" - subsystem: + - "Fatty acid degradation" - annotation: !!omap - bigg.reaction: "HMR_3102" - kegg.pathway: @@ -61794,6 +63370,7 @@ - gene_reaction_rule: "YGL205W" - eccodes: "1.3.3.6" - subsystem: + - "Fatty acid degradation" - annotation: !!omap - bigg.reaction: "HMR_3098" - kegg.pathway: @@ -61819,6 +63396,7 @@ - gene_reaction_rule: "YGL205W" - eccodes: "1.3.3.6" - subsystem: + - "Fatty acid degradation" - annotation: !!omap - kegg.pathway: - "sce00071" @@ -61842,6 +63420,7 @@ - gene_reaction_rule: "YGL205W" - eccodes: "1.3.3.6" - subsystem: + - "Fatty acid degradation" - annotation: !!omap - kegg.pathway: - "sce00071" @@ -61865,6 +63444,7 @@ - gene_reaction_rule: "YGL205W" - eccodes: "1.3.3.6" - subsystem: + - "Fatty acid degradation" - annotation: !!omap - kegg.pathway: - "sce00071" @@ -61888,6 +63468,7 @@ - gene_reaction_rule: "YGL205W" - eccodes: "1.3.3.6" - subsystem: + - "Fatty acid degradation" - annotation: !!omap - bigg.reaction: "HMR_3062" - kegg.pathway: @@ -61914,6 +63495,7 @@ - gene_reaction_rule: "YGL205W" - eccodes: "1.3.3.6" - subsystem: + - "Fatty acid degradation" - annotation: !!omap - kegg.pathway: - "sce00071" @@ -61937,6 +63519,7 @@ - gene_reaction_rule: "YGL205W" - eccodes: "1.3.3.6" - subsystem: + - "Fatty acid degradation" - annotation: !!omap - kegg.pathway: - "sce00071" @@ -61960,6 +63543,7 @@ - gene_reaction_rule: "YGL205W" - eccodes: "1.3.3.6" - subsystem: + - "Fatty acid degradation" - annotation: !!omap - kegg.pathway: - "sce00071" @@ -61983,6 +63567,7 @@ - gene_reaction_rule: "YGL205W" - eccodes: "1.3.3.6" - subsystem: + - "Fatty acid degradation" - annotation: !!omap - kegg.pathway: - "sce00071" @@ -62006,6 +63591,7 @@ - gene_reaction_rule: "YGL205W" - eccodes: "1.3.3.6" - subsystem: + - "Fatty acid degradation" - annotation: !!omap - kegg.pathway: - "sce00071" @@ -62029,6 +63615,7 @@ - gene_reaction_rule: "YGL205W" - eccodes: "1.3.3.6" - subsystem: + - "Fatty acid degradation" - annotation: !!omap - kegg.pathway: - "sce00071" @@ -62053,6 +63640,7 @@ - "1.1.1.n12" - "4.2.1.119" - subsystem: + - "Fatty acid degradation" - annotation: !!omap - bigg.reaction: "ECOAH4p" - kegg.reaction: "R04744" @@ -62074,6 +63662,7 @@ - "1.1.1.n12" - "4.2.1.119" - subsystem: + - "Fatty acid degradation" - annotation: !!omap - bigg.reaction: "ECOAH5p" - kegg.reaction: "R04170" @@ -62095,6 +63684,7 @@ - "1.1.1.n12" - "4.2.1.119" - subsystem: + - "Fatty acid degradation" - annotation: !!omap - bigg.reaction: "ECOAH6p" - kegg.reaction: "R04740" @@ -62116,6 +63706,7 @@ - "1.1.1.n12" - "4.2.1.119" - subsystem: + - "Fatty acid degradation" - annotation: !!omap - bigg.reaction: "ECOAH7p" - kegg.reaction: "R04738" @@ -62137,6 +63728,7 @@ - "1.1.1.n12" - "4.2.1.119" - subsystem: + - "Fatty acid degradation" - annotation: !!omap - bigg.reaction: "HMR_3075" - kegg.reaction: "R07760" @@ -62158,6 +63750,7 @@ - "1.1.1.n12" - "4.2.1.119" - subsystem: + - "Fatty acid degradation" - annotation: !!omap - pubmed: "12697341" - sbo: "SBO:0000176" @@ -62177,6 +63770,7 @@ - "1.1.1.n12" - "4.2.1.119" - subsystem: + - "Fatty acid degradation" - annotation: !!omap - pubmed: "12697341" - sbo: "SBO:0000176" @@ -62195,6 +63789,7 @@ - "1.1.1.n12" - "4.2.1.119" - subsystem: + - "Fatty acid degradation" - annotation: !!omap - pubmed: "12697341" - sbo: "SBO:0000176" @@ -62214,6 +63809,7 @@ - "1.1.1.n12" - "4.2.1.119" - subsystem: + - "Fatty acid degradation" - annotation: !!omap - metanetx.reaction: "MNXR118594" - pubmed: "12697341" @@ -62233,6 +63829,7 @@ - "1.1.1.n12" - "4.2.1.119" - subsystem: + - "Fatty acid degradation" - annotation: !!omap - pubmed: "12697341" - sbo: "SBO:0000176" @@ -62251,6 +63848,7 @@ - "1.1.1.n12" - "4.2.1.119" - subsystem: + - "Fatty acid degradation" - annotation: !!omap - pubmed: "12697341" - sbo: "SBO:0000176" @@ -62269,6 +63867,7 @@ - "1.1.1.n12" - "4.2.1.119" - subsystem: + - "Fatty acid degradation" - annotation: !!omap - metanetx.reaction: "MNXR118009" - pubmed: "12697341" @@ -62288,6 +63887,7 @@ - "1.1.1.n12" - "4.2.1.119" - subsystem: + - "Fatty acid degradation" - annotation: !!omap - pubmed: "12697341" - sbo: "SBO:0000176" @@ -62306,6 +63906,7 @@ - "1.1.1.n12" - "4.2.1.119" - subsystem: + - "Fatty acid degradation" - annotation: !!omap - pubmed: "12697341" - sbo: "SBO:0000176" @@ -62324,6 +63925,7 @@ - "1.1.1.n12" - "4.2.1.119" - subsystem: + - "Fatty acid degradation" - annotation: !!omap - pubmed: "12697341" - sbo: "SBO:0000176" @@ -62343,6 +63945,7 @@ - "1.1.1.n12" - "4.2.1.119" - subsystem: + - "Fatty acid degradation" - annotation: !!omap - pubmed: "12697341" - sbo: "SBO:0000176" @@ -62361,6 +63964,7 @@ - "1.1.1.n12" - "4.2.1.119" - subsystem: + - "Fatty acid degradation" - annotation: !!omap - pubmed: "12697341" - sbo: "SBO:0000176" @@ -62379,6 +63983,7 @@ - "1.1.1.n12" - "4.2.1.119" - subsystem: + - "Fatty acid degradation" - annotation: !!omap - pubmed: "12697341" - sbo: "SBO:0000176" @@ -62399,6 +64004,7 @@ - "1.1.1.n12" - "4.2.1.119" - subsystem: + - "Fatty acid degradation" - annotation: !!omap - bigg.reaction: "HACD4p" - kegg.reaction: "R04743" @@ -62422,6 +64028,7 @@ - "1.1.1.n12" - "4.2.1.119" - subsystem: + - "Fatty acid degradation" - annotation: !!omap - bigg.reaction: "HACD5p" - kegg.reaction: "R04741" @@ -62445,6 +64052,7 @@ - "1.1.1.n12" - "4.2.1.119" - subsystem: + - "Fatty acid degradation" - annotation: !!omap - bigg.reaction: "HACD7p" - kegg.reaction: "R04737" @@ -62468,6 +64076,7 @@ - "1.1.1.n12" - "4.2.1.119" - subsystem: + - "Fatty acid degradation" - annotation: !!omap - bigg.reaction: "HMR_3076" - metanetx.reaction: "MNXR126787" @@ -62490,6 +64099,7 @@ - "1.1.1.n12" - "4.2.1.119" - subsystem: + - "Fatty acid degradation" - annotation: !!omap - pubmed: "12697341" - sbo: "SBO:0000176" @@ -62510,6 +64120,7 @@ - "1.1.1.n12" - "4.2.1.119" - subsystem: + - "Fatty acid degradation" - annotation: !!omap - pubmed: "12697341" - sbo: "SBO:0000176" @@ -62530,6 +64141,7 @@ - "1.1.1.n12" - "4.2.1.119" - subsystem: + - "Fatty acid degradation" - annotation: !!omap - pubmed: "12697341" - sbo: "SBO:0000176" @@ -62550,6 +64162,7 @@ - "1.1.1.n12" - "4.2.1.119" - subsystem: + - "Fatty acid degradation" - annotation: !!omap - pubmed: "12697341" - sbo: "SBO:0000176" @@ -62570,6 +64183,7 @@ - "1.1.1.n12" - "4.2.1.119" - subsystem: + - "Fatty acid degradation" - annotation: !!omap - pubmed: "12697341" - sbo: "SBO:0000176" @@ -62590,6 +64204,7 @@ - "1.1.1.n12" - "4.2.1.119" - subsystem: + - "Fatty acid degradation" - annotation: !!omap - pubmed: "12697341" - sbo: "SBO:0000176" @@ -62610,6 +64225,7 @@ - "1.1.1.n12" - "4.2.1.119" - subsystem: + - "Fatty acid degradation" - annotation: !!omap - pubmed: "12697341" - sbo: "SBO:0000176" @@ -62630,6 +64246,7 @@ - "1.1.1.n12" - "4.2.1.119" - subsystem: + - "Fatty acid degradation" - annotation: !!omap - pubmed: "12697341" - sbo: "SBO:0000176" @@ -62650,6 +64267,7 @@ - "1.1.1.n12" - "4.2.1.119" - subsystem: + - "Fatty acid degradation" - annotation: !!omap - pubmed: "12697341" - sbo: "SBO:0000176" @@ -62670,6 +64288,7 @@ - "1.1.1.n12" - "4.2.1.119" - subsystem: + - "Fatty acid degradation" - annotation: !!omap - pubmed: "12697341" - sbo: "SBO:0000176" @@ -62690,6 +64309,7 @@ - "1.1.1.n12" - "4.2.1.119" - subsystem: + - "Fatty acid degradation" - annotation: !!omap - pubmed: "12697341" - sbo: "SBO:0000176" @@ -62710,6 +64330,7 @@ - "1.1.1.n12" - "4.2.1.119" - subsystem: + - "Fatty acid degradation" - annotation: !!omap - pubmed: "12697341" - sbo: "SBO:0000176" @@ -62730,6 +64351,7 @@ - "1.1.1.n12" - "4.2.1.119" - subsystem: + - "Fatty acid degradation" - annotation: !!omap - pubmed: "12697341" - sbo: "SBO:0000176" @@ -62746,6 +64368,7 @@ - gene_reaction_rule: "YIL160C" - eccodes: "2.3.1.16" - subsystem: + - "Fatty acid degradation" - annotation: !!omap - bigg.reaction: "ACACT1x" - kegg.pathway: @@ -62774,6 +64397,7 @@ - gene_reaction_rule: "YIL160C" - eccodes: "2.3.1.16" - subsystem: + - "Fatty acid degradation" - annotation: !!omap - bigg.reaction: "ACACT2" - kegg.pathway: @@ -62800,6 +64424,7 @@ - gene_reaction_rule: "YIL160C" - eccodes: "2.3.1.16" - subsystem: + - "Fatty acid degradation" - annotation: !!omap - bigg.reaction: "ACACT3" - kegg.pathway: @@ -62826,6 +64451,7 @@ - gene_reaction_rule: "YIL160C" - eccodes: "2.3.1.16" - subsystem: + - "Fatty acid degradation" - annotation: !!omap - bigg.reaction: "HMR_3073" - kegg.pathway: @@ -62852,6 +64478,7 @@ - gene_reaction_rule: "YIL160C" - eccodes: "2.3.1.16" - subsystem: + - "Fatty acid degradation" - annotation: !!omap - bigg.reaction: "HMR_3069" - kegg.pathway: @@ -62878,6 +64505,7 @@ - gene_reaction_rule: "YIL160C" - eccodes: "2.3.1.16" - subsystem: + - "Fatty acid degradation" - annotation: !!omap - bigg.reaction: "HMR_3065" - kegg.pathway: @@ -62904,6 +64532,7 @@ - gene_reaction_rule: "YIL160C" - eccodes: "2.3.1.16" - subsystem: + - "Fatty acid degradation" - annotation: !!omap - kegg.pathway: - "sce00071" @@ -62929,6 +64558,7 @@ - gene_reaction_rule: "YIL160C" - eccodes: "2.3.1.16" - subsystem: + - "Fatty acid degradation" - annotation: !!omap - kegg.pathway: - "sce00071" @@ -62954,6 +64584,7 @@ - gene_reaction_rule: "YIL160C" - eccodes: "2.3.1.16" - subsystem: + - "Fatty acid degradation" - annotation: !!omap - kegg.pathway: - "sce00071" @@ -62979,6 +64610,7 @@ - gene_reaction_rule: "YIL160C" - eccodes: "2.3.1.16" - subsystem: + - "Fatty acid degradation" - annotation: !!omap - kegg.pathway: - "sce00071" @@ -63004,6 +64636,7 @@ - gene_reaction_rule: "YIL160C" - eccodes: "2.3.1.16" - subsystem: + - "Fatty acid degradation" - annotation: !!omap - kegg.pathway: - "sce00071" @@ -63029,6 +64662,7 @@ - gene_reaction_rule: "YIL160C" - eccodes: "2.3.1.16" - subsystem: + - "Fatty acid degradation" - annotation: !!omap - kegg.pathway: - "sce00071" @@ -63053,6 +64687,7 @@ - gene_reaction_rule: "YLR284C" - eccodes: "5.3.3.8" - subsystem: + - "Fatty acid degradation" - annotation: !!omap - kegg.pathway: - "sce00071" @@ -63071,6 +64706,7 @@ - gene_reaction_rule: "YLR284C" - eccodes: "5.3.3.8" - subsystem: + - "Fatty acid degradation" - annotation: !!omap - kegg.pathway: - "sce00071" @@ -63090,6 +64726,7 @@ - gene_reaction_rule: "YLR284C" - eccodes: "5.3.3.8" - subsystem: + - "Fatty acid degradation" - annotation: !!omap - bigg.reaction: "FAOXC121x" - kegg.pathway: @@ -63110,6 +64747,7 @@ - gene_reaction_rule: "YLR284C" - eccodes: "5.3.3.8" - subsystem: + - "Fatty acid degradation" - annotation: !!omap - kegg.pathway: - "sce00071" @@ -63128,6 +64766,7 @@ - gene_reaction_rule: "YLR284C" - eccodes: "5.3.3.8" - subsystem: + - "Fatty acid degradation" - annotation: !!omap - kegg.pathway: - "sce00071" @@ -63147,6 +64786,7 @@ - gene_reaction_rule: "YLR284C" - eccodes: "5.3.3.8" - subsystem: + - "Fatty acid degradation" - annotation: !!omap - kegg.pathway: - "sce00071" @@ -63165,6 +64805,7 @@ - gene_reaction_rule: "YOR180C" - eccodes: "5.3.3.-" - subsystem: + - "Fatty acid degradation" - annotation: !!omap - pubmed: "12697341" - sbo: "SBO:0000176" @@ -63180,6 +64821,7 @@ - gene_reaction_rule: "YOR180C" - eccodes: "5.3.3.-" - subsystem: + - "Fatty acid degradation" - annotation: !!omap - pubmed: "12697341" - sbo: "SBO:0000176" @@ -63198,6 +64840,7 @@ - gene_reaction_rule: "YNL202W" - eccodes: "1.3.1.34" - subsystem: + - "Ascospore biosynthesis" - annotation: !!omap - kegg.pathway: "sce04146" - pubmed: "12697341" @@ -63217,6 +64860,7 @@ - gene_reaction_rule: "YNL202W" - eccodes: "1.3.1.34" - subsystem: + - "Ascospore biosynthesis" - annotation: !!omap - kegg.pathway: "sce04146" - pubmed: "12697341" @@ -63234,6 +64878,7 @@ - gene_reaction_rule: "YLR304C" - eccodes: "4.2.1.3" - subsystem: + - "Citrate cycle (TCA cycle)" - annotation: !!omap - bigg.reaction: "ACONTb" - kegg.pathway: @@ -63265,6 +64910,7 @@ - "2.3.1.15" - "2.3.1.42" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00561" @@ -63289,6 +64935,7 @@ - "2.3.1.15" - "2.3.1.42" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00561" @@ -63313,6 +64960,7 @@ - "2.3.1.15" - "2.3.1.42" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00561" @@ -63337,6 +64985,7 @@ - "2.3.1.15" - "2.3.1.42" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00561" @@ -63361,6 +65010,7 @@ - "2.3.1.15" - "2.3.1.42" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00561" @@ -63385,6 +65035,7 @@ - "2.3.1.15" - "2.3.1.42" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00561" @@ -63409,6 +65060,7 @@ - "2.3.1.15" - "2.3.1.42" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00561" @@ -63433,6 +65085,7 @@ - "2.3.1.15" - "2.3.1.42" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00561" @@ -63457,6 +65110,7 @@ - "2.3.1.15" - "2.3.1.42" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00561" @@ -63481,6 +65135,7 @@ - "2.3.1.15" - "2.3.1.42" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00561" @@ -63505,6 +65160,7 @@ - "2.3.1.15" - "2.3.1.42" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00561" @@ -63529,6 +65185,7 @@ - "2.3.1.15" - "2.3.1.42" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00561" @@ -63553,6 +65210,7 @@ - "2.3.1.15" - "2.3.1.42" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00561" @@ -63577,6 +65235,7 @@ - "2.3.1.15" - "2.3.1.42" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00561" @@ -63601,6 +65260,7 @@ - "2.3.1.15" - "2.3.1.42" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00561" @@ -63625,6 +65285,7 @@ - "2.3.1.15" - "2.3.1.42" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00561" @@ -63647,6 +65308,7 @@ - gene_reaction_rule: "YIL124W" - eccodes: "1.1.1.101" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -63666,6 +65328,7 @@ - gene_reaction_rule: "YIL124W" - eccodes: "1.1.1.101" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -63685,6 +65348,7 @@ - gene_reaction_rule: "YIL124W" - eccodes: "1.1.1.101" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -63704,6 +65368,7 @@ - gene_reaction_rule: "YIL124W" - eccodes: "1.1.1.101" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -63723,6 +65388,7 @@ - gene_reaction_rule: "YIL124W" - eccodes: "1.1.1.101" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -63742,6 +65408,7 @@ - gene_reaction_rule: "YIL124W" - eccodes: "1.1.1.101" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -63761,6 +65428,7 @@ - gene_reaction_rule: "YIL124W" - eccodes: "1.1.1.101" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -63780,6 +65448,7 @@ - gene_reaction_rule: "YIL124W" - eccodes: "1.1.1.101" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -63800,6 +65469,7 @@ - "2.3.1.23" - "2.3.1.51" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00561" @@ -63823,6 +65493,7 @@ - "2.3.1.23" - "2.3.1.51" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00561" @@ -63846,6 +65517,7 @@ - "2.3.1.23" - "2.3.1.51" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00561" @@ -63869,6 +65541,7 @@ - "2.3.1.23" - "2.3.1.51" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00561" @@ -63892,6 +65565,7 @@ - "2.3.1.23" - "2.3.1.51" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00561" @@ -63915,6 +65589,7 @@ - "2.3.1.23" - "2.3.1.51" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00561" @@ -63938,6 +65613,7 @@ - "2.3.1.23" - "2.3.1.51" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00561" @@ -63961,6 +65637,7 @@ - "2.3.1.23" - "2.3.1.51" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00561" @@ -63984,6 +65661,7 @@ - "2.3.1.51" - "3.1.1.3" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00100" @@ -64008,6 +65686,7 @@ - "2.3.1.51" - "3.1.1.3" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00100" @@ -64032,6 +65711,7 @@ - "2.3.1.51" - "3.1.1.3" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00100" @@ -64056,6 +65736,7 @@ - "2.3.1.51" - "3.1.1.3" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00100" @@ -64079,6 +65760,7 @@ - gene_reaction_rule: "YMR165C" - eccodes: "3.1.3.4" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00561" @@ -64101,6 +65783,7 @@ - gene_reaction_rule: "YMR165C" - eccodes: "3.1.3.4" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00561" @@ -64123,6 +65806,7 @@ - gene_reaction_rule: "YMR165C" - eccodes: "3.1.3.4" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00561" @@ -64145,6 +65829,7 @@ - gene_reaction_rule: "YMR165C" - eccodes: "3.1.3.4" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00561" @@ -64167,6 +65852,7 @@ - gene_reaction_rule: "YMR165C" - eccodes: "3.1.3.4" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00561" @@ -64189,6 +65875,7 @@ - gene_reaction_rule: "YMR165C" - eccodes: "3.1.3.4" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00561" @@ -64211,6 +65898,7 @@ - gene_reaction_rule: "YMR165C" - eccodes: "3.1.3.4" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00561" @@ -64233,6 +65921,7 @@ - gene_reaction_rule: "YMR165C" - eccodes: "3.1.3.4" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00561" @@ -64257,6 +65946,7 @@ - "3.1.3.4" - "3.1.3.81" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00561" @@ -64281,6 +65971,7 @@ - "3.1.3.4" - "3.1.3.81" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00561" @@ -64305,6 +65996,7 @@ - "3.1.3.4" - "3.1.3.81" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00561" @@ -64329,6 +66021,7 @@ - "3.1.3.4" - "3.1.3.81" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00561" @@ -64353,6 +66046,7 @@ - "3.1.3.4" - "3.1.3.81" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00561" @@ -64377,6 +66071,7 @@ - "3.1.3.4" - "3.1.3.81" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00561" @@ -64401,6 +66096,7 @@ - "3.1.3.4" - "3.1.3.81" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00561" @@ -64425,6 +66121,7 @@ - "3.1.3.4" - "3.1.3.81" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00561" @@ -64449,6 +66146,7 @@ - "3.1.3.-" - "3.1.3.4" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - pubmed: "22345606" - sbo: "SBO:0000176" @@ -64469,6 +66167,7 @@ - "3.1.3.-" - "3.1.3.4" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - pubmed: "22345606" - sbo: "SBO:0000176" @@ -64489,6 +66188,7 @@ - "3.1.3.-" - "3.1.3.4" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - pubmed: "22345606" - sbo: "SBO:0000176" @@ -64509,6 +66209,7 @@ - "3.1.3.-" - "3.1.3.4" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - pubmed: "22345606" - sbo: "SBO:0000176" @@ -64529,6 +66230,7 @@ - "3.1.3.-" - "3.1.3.4" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - pubmed: "22345606" - sbo: "SBO:0000176" @@ -64549,6 +66251,7 @@ - "3.1.3.-" - "3.1.3.4" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - pubmed: "22345606" - sbo: "SBO:0000176" @@ -64569,6 +66272,7 @@ - "3.1.3.-" - "3.1.3.4" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - pubmed: "22345606" - sbo: "SBO:0000176" @@ -64589,6 +66293,7 @@ - "3.1.3.-" - "3.1.3.4" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - pubmed: "22345606" - sbo: "SBO:0000176" @@ -64609,6 +66314,7 @@ - "2.3.1.22" - "2.3.1.26" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00100" @@ -64632,6 +66338,7 @@ - "2.3.1.22" - "2.3.1.26" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00100" @@ -64655,6 +66362,7 @@ - "2.3.1.22" - "2.3.1.26" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00100" @@ -64678,6 +66386,7 @@ - "2.3.1.22" - "2.3.1.26" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00100" @@ -64701,6 +66410,7 @@ - "2.3.1.22" - "2.3.1.26" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00100" @@ -64724,6 +66434,7 @@ - "2.3.1.22" - "2.3.1.26" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00100" @@ -64747,6 +66458,7 @@ - "2.3.1.22" - "2.3.1.26" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00100" @@ -64770,6 +66482,7 @@ - "2.3.1.22" - "2.3.1.26" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00100" @@ -64793,6 +66506,7 @@ - "2.3.1.22" - "2.3.1.26" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00100" @@ -64816,6 +66530,7 @@ - "2.3.1.22" - "2.3.1.26" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00100" @@ -64839,6 +66554,7 @@ - "2.3.1.22" - "2.3.1.26" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00100" @@ -64862,6 +66578,7 @@ - "2.3.1.22" - "2.3.1.26" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00100" @@ -64885,6 +66602,7 @@ - "2.3.1.22" - "2.3.1.26" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00100" @@ -64908,6 +66626,7 @@ - "2.3.1.22" - "2.3.1.26" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00100" @@ -64931,6 +66650,7 @@ - "2.3.1.22" - "2.3.1.26" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00100" @@ -64954,6 +66674,7 @@ - "2.3.1.22" - "2.3.1.26" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00100" @@ -64977,6 +66698,7 @@ - "2.3.1.22" - "2.3.1.26" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00100" @@ -65000,6 +66722,7 @@ - "2.3.1.22" - "2.3.1.26" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00100" @@ -65023,6 +66746,7 @@ - "2.3.1.22" - "2.3.1.26" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00100" @@ -65046,6 +66770,7 @@ - "2.3.1.22" - "2.3.1.26" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00100" @@ -65069,6 +66794,7 @@ - "2.3.1.22" - "2.3.1.26" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00100" @@ -65092,6 +66818,7 @@ - "2.3.1.22" - "2.3.1.26" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00100" @@ -65115,6 +66842,7 @@ - "2.3.1.22" - "2.3.1.26" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00100" @@ -65138,6 +66866,7 @@ - "2.3.1.22" - "2.3.1.26" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00100" @@ -65161,6 +66890,7 @@ - "2.3.1.22" - "2.3.1.26" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00100" @@ -65184,6 +66914,7 @@ - "2.3.1.22" - "2.3.1.26" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00100" @@ -65207,6 +66938,7 @@ - "2.3.1.22" - "2.3.1.26" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00100" @@ -65230,6 +66962,7 @@ - "2.3.1.22" - "2.3.1.26" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00100" @@ -65253,6 +66986,7 @@ - "2.3.1.22" - "2.3.1.26" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00100" @@ -65276,6 +67010,7 @@ - "2.3.1.22" - "2.3.1.26" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00100" @@ -65299,6 +67034,7 @@ - "2.3.1.22" - "2.3.1.26" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00100" @@ -65322,6 +67058,7 @@ - "2.3.1.22" - "2.3.1.26" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00100" @@ -65344,6 +67081,7 @@ - "2.3.1.20" - "2.3.1.22" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -65364,6 +67102,7 @@ - "2.3.1.20" - "2.3.1.22" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -65384,6 +67123,7 @@ - "2.3.1.20" - "2.3.1.22" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -65404,6 +67144,7 @@ - "2.3.1.20" - "2.3.1.22" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -65424,6 +67165,7 @@ - "2.3.1.20" - "2.3.1.22" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -65444,6 +67186,7 @@ - "2.3.1.20" - "2.3.1.22" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -65464,6 +67207,7 @@ - "2.3.1.20" - "2.3.1.22" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -65484,6 +67228,7 @@ - "2.3.1.20" - "2.3.1.22" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -65504,6 +67249,7 @@ - "2.3.1.20" - "2.3.1.22" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -65524,6 +67270,7 @@ - "2.3.1.20" - "2.3.1.22" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -65544,6 +67291,7 @@ - "2.3.1.20" - "2.3.1.22" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -65564,6 +67312,7 @@ - "2.3.1.20" - "2.3.1.22" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -65584,6 +67333,7 @@ - "2.3.1.20" - "2.3.1.22" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -65604,6 +67354,7 @@ - "2.3.1.20" - "2.3.1.22" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -65624,6 +67375,7 @@ - "2.3.1.20" - "2.3.1.22" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -65644,6 +67396,7 @@ - "2.3.1.20" - "2.3.1.22" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -65664,6 +67417,7 @@ - "2.3.1.20" - "2.3.1.22" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -65684,6 +67438,7 @@ - "2.3.1.20" - "2.3.1.22" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -65704,6 +67459,7 @@ - "2.3.1.20" - "2.3.1.22" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -65724,6 +67480,7 @@ - "2.3.1.20" - "2.3.1.22" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -65744,6 +67501,7 @@ - "2.3.1.20" - "2.3.1.22" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -65764,6 +67522,7 @@ - "2.3.1.20" - "2.3.1.22" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -65784,6 +67543,7 @@ - "2.3.1.20" - "2.3.1.22" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -65804,6 +67564,7 @@ - "2.3.1.20" - "2.3.1.22" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -65824,6 +67585,7 @@ - "2.3.1.20" - "2.3.1.22" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -65844,6 +67606,7 @@ - "2.3.1.20" - "2.3.1.22" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -65864,6 +67627,7 @@ - "2.3.1.20" - "2.3.1.22" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -65884,6 +67648,7 @@ - "2.3.1.20" - "2.3.1.22" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -65904,6 +67669,7 @@ - "2.3.1.20" - "2.3.1.22" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -65924,6 +67690,7 @@ - "2.3.1.20" - "2.3.1.22" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -65944,6 +67711,7 @@ - "2.3.1.20" - "2.3.1.22" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -65964,6 +67732,7 @@ - "2.3.1.20" - "2.3.1.22" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -65983,6 +67752,7 @@ - gene_reaction_rule: "YBR029C" - eccodes: "2.7.7.41" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00564" @@ -66005,6 +67775,7 @@ - gene_reaction_rule: "YBR029C" - eccodes: "2.7.7.41" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00564" @@ -66027,6 +67798,7 @@ - gene_reaction_rule: "YBR029C" - eccodes: "2.7.7.41" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00564" @@ -66049,6 +67821,7 @@ - gene_reaction_rule: "YBR029C" - eccodes: "2.7.7.41" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00564" @@ -66071,6 +67844,7 @@ - gene_reaction_rule: "YBR029C" - eccodes: "2.7.7.41" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00564" @@ -66093,6 +67867,7 @@ - gene_reaction_rule: "YBR029C" - eccodes: "2.7.7.41" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00564" @@ -66115,6 +67890,7 @@ - gene_reaction_rule: "YBR029C" - eccodes: "2.7.7.41" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00564" @@ -66137,6 +67913,7 @@ - gene_reaction_rule: "YBR029C" - eccodes: "2.7.7.41" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00564" @@ -66159,6 +67936,7 @@ - gene_reaction_rule: "YBR029C" - eccodes: "2.7.7.41" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00564" @@ -66181,6 +67959,7 @@ - gene_reaction_rule: "YBR029C" - eccodes: "2.7.7.41" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00564" @@ -66203,6 +67982,7 @@ - gene_reaction_rule: "YBR029C" - eccodes: "2.7.7.41" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00564" @@ -66225,6 +68005,7 @@ - gene_reaction_rule: "YBR029C" - eccodes: "2.7.7.41" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00564" @@ -66247,6 +68028,7 @@ - gene_reaction_rule: "YBR029C" - eccodes: "2.7.7.41" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00564" @@ -66269,6 +68051,7 @@ - gene_reaction_rule: "YBR029C" - eccodes: "2.7.7.41" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00564" @@ -66291,6 +68074,7 @@ - gene_reaction_rule: "YER026C" - eccodes: "2.7.8.8" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00260" @@ -66313,6 +68097,7 @@ - gene_reaction_rule: "YER026C" - eccodes: "2.7.8.8" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00260" @@ -66335,6 +68120,7 @@ - gene_reaction_rule: "YER026C" - eccodes: "2.7.8.8" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00260" @@ -66357,6 +68143,7 @@ - gene_reaction_rule: "YER026C" - eccodes: "2.7.8.8" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00260" @@ -66379,6 +68166,7 @@ - gene_reaction_rule: "YER026C" - eccodes: "2.7.8.8" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00260" @@ -66401,6 +68189,7 @@ - gene_reaction_rule: "YER026C" - eccodes: "2.7.8.8" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00260" @@ -66423,6 +68212,7 @@ - gene_reaction_rule: "YER026C" - eccodes: "2.7.8.8" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00260" @@ -66445,6 +68235,7 @@ - gene_reaction_rule: "YER026C" - eccodes: "2.7.8.8" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00260" @@ -66467,6 +68258,7 @@ - gene_reaction_rule: "YPR113W" - eccodes: "2.7.8.11" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -66489,6 +68281,7 @@ - gene_reaction_rule: "YPR113W" - eccodes: "2.7.8.11" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -66511,6 +68304,7 @@ - gene_reaction_rule: "YPR113W" - eccodes: "2.7.8.11" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -66533,6 +68327,7 @@ - gene_reaction_rule: "YPR113W" - eccodes: "2.7.8.11" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -66555,6 +68350,7 @@ - gene_reaction_rule: "YPR113W" - eccodes: "2.7.8.11" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -66577,6 +68373,7 @@ - gene_reaction_rule: "YPR113W" - eccodes: "2.7.8.11" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -66599,6 +68396,7 @@ - gene_reaction_rule: "YPR113W" - eccodes: "2.7.8.11" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -66621,6 +68419,7 @@ - gene_reaction_rule: "YPR113W" - eccodes: "2.7.8.11" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -66642,6 +68441,7 @@ - gene_reaction_rule: "YBR042C" - eccodes: "2.3.-.-" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - pubmed: "22345606" - sbo: "SBO:0000176" @@ -66659,6 +68459,7 @@ - gene_reaction_rule: "YBR042C" - eccodes: "2.3.-.-" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - pubmed: "22345606" - sbo: "SBO:0000176" @@ -66675,6 +68476,7 @@ - gene_reaction_rule: "YNL169C" - eccodes: "4.1.1.65" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00564" @@ -66694,6 +68496,7 @@ - gene_reaction_rule: "YNL169C" - eccodes: "4.1.1.65" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00564" @@ -66713,6 +68516,7 @@ - gene_reaction_rule: "YNL169C" - eccodes: "4.1.1.65" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00564" @@ -66732,6 +68536,7 @@ - gene_reaction_rule: "YNL169C" - eccodes: "4.1.1.65" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00564" @@ -66751,6 +68556,7 @@ - gene_reaction_rule: "YNL169C" - eccodes: "4.1.1.65" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00564" @@ -66770,6 +68576,7 @@ - gene_reaction_rule: "YNL169C" - eccodes: "4.1.1.65" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00564" @@ -66789,6 +68596,7 @@ - gene_reaction_rule: "YNL169C" - eccodes: "4.1.1.65" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00564" @@ -66808,6 +68616,7 @@ - gene_reaction_rule: "YNL169C" - eccodes: "4.1.1.65" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00564" @@ -66827,6 +68636,7 @@ - gene_reaction_rule: "YGR170W" - eccodes: "4.1.1.65" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00564" @@ -66846,6 +68656,7 @@ - gene_reaction_rule: "YGR170W" - eccodes: "4.1.1.65" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00564" @@ -66865,6 +68676,7 @@ - gene_reaction_rule: "YGR170W" - eccodes: "4.1.1.65" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00564" @@ -66884,6 +68696,7 @@ - gene_reaction_rule: "YGR170W" - eccodes: "4.1.1.65" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00564" @@ -66903,6 +68716,7 @@ - gene_reaction_rule: "YGR170W" - eccodes: "4.1.1.65" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00564" @@ -66922,6 +68736,7 @@ - gene_reaction_rule: "YGR170W" - eccodes: "4.1.1.65" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00564" @@ -66941,6 +68756,7 @@ - gene_reaction_rule: "YGR170W" - eccodes: "4.1.1.65" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00564" @@ -66960,6 +68776,7 @@ - gene_reaction_rule: "YGR170W" - eccodes: "4.1.1.65" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00564" @@ -66979,6 +68796,7 @@ - gene_reaction_rule: "YGR170W" - eccodes: "4.1.1.65" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00564" @@ -66998,6 +68816,7 @@ - gene_reaction_rule: "YGR170W" - eccodes: "4.1.1.65" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00564" @@ -67017,6 +68836,7 @@ - gene_reaction_rule: "YGR170W" - eccodes: "4.1.1.65" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00564" @@ -67036,6 +68856,7 @@ - gene_reaction_rule: "YGR170W" - eccodes: "4.1.1.65" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00564" @@ -67055,6 +68876,7 @@ - gene_reaction_rule: "YGR170W" - eccodes: "4.1.1.65" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00564" @@ -67074,6 +68896,7 @@ - gene_reaction_rule: "YGR170W" - eccodes: "4.1.1.65" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00564" @@ -67093,6 +68916,7 @@ - gene_reaction_rule: "YGR170W" - eccodes: "4.1.1.65" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00564" @@ -67112,6 +68936,7 @@ - gene_reaction_rule: "YGR170W" - eccodes: "4.1.1.65" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00564" @@ -67135,6 +68960,7 @@ - "2.1.1.17" - "2.1.1.71" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00564" @@ -67158,6 +68984,7 @@ - "2.1.1.17" - "2.1.1.71" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00564" @@ -67181,6 +69008,7 @@ - "2.1.1.17" - "2.1.1.71" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00564" @@ -67204,6 +69032,7 @@ - "2.1.1.17" - "2.1.1.71" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00564" @@ -67227,6 +69056,7 @@ - "2.1.1.17" - "2.1.1.71" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00564" @@ -67250,6 +69080,7 @@ - "2.1.1.17" - "2.1.1.71" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00564" @@ -67273,6 +69104,7 @@ - "2.1.1.17" - "2.1.1.71" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00564" @@ -67296,6 +69128,7 @@ - "2.1.1.17" - "2.1.1.71" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00564" @@ -67319,6 +69152,7 @@ - "2.1.1.17" - "2.1.1.71" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00564" @@ -67342,6 +69176,7 @@ - "2.1.1.17" - "2.1.1.71" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00564" @@ -67365,6 +69200,7 @@ - "2.1.1.17" - "2.1.1.71" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00564" @@ -67388,6 +69224,7 @@ - "2.1.1.17" - "2.1.1.71" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00564" @@ -67411,6 +69248,7 @@ - "2.1.1.17" - "2.1.1.71" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00564" @@ -67434,6 +69272,7 @@ - "2.1.1.17" - "2.1.1.71" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00564" @@ -67457,6 +69296,7 @@ - "2.1.1.17" - "2.1.1.71" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00564" @@ -67480,6 +69320,7 @@ - "2.1.1.17" - "2.1.1.71" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00564" @@ -67503,6 +69344,7 @@ - "2.1.1.17" - "2.1.1.71" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00564" @@ -67526,6 +69368,7 @@ - "2.1.1.17" - "2.1.1.71" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00564" @@ -67549,6 +69392,7 @@ - "2.1.1.17" - "2.1.1.71" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00564" @@ -67572,6 +69416,7 @@ - "2.1.1.17" - "2.1.1.71" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00564" @@ -67595,6 +69440,7 @@ - "2.1.1.17" - "2.1.1.71" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00564" @@ -67618,6 +69464,7 @@ - "2.1.1.17" - "2.1.1.71" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00564" @@ -67641,6 +69488,7 @@ - "2.1.1.17" - "2.1.1.71" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00564" @@ -67664,6 +69512,7 @@ - "2.1.1.17" - "2.1.1.71" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00564" @@ -67685,6 +69534,7 @@ - gene_reaction_rule: "YOR311C" - eccodes: "2.7.1.174" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00564" @@ -67706,6 +69556,7 @@ - gene_reaction_rule: "YOR311C" - eccodes: "2.7.1.174" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00564" @@ -67727,6 +69578,7 @@ - gene_reaction_rule: "YOR311C" - eccodes: "2.7.1.174" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00564" @@ -67748,6 +69600,7 @@ - gene_reaction_rule: "YOR311C" - eccodes: "2.7.1.174" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00564" @@ -67769,6 +69622,7 @@ - gene_reaction_rule: "YOR311C" - eccodes: "2.7.1.174" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00564" @@ -67790,6 +69644,7 @@ - gene_reaction_rule: "YOR311C" - eccodes: "2.7.1.174" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00564" @@ -67811,6 +69666,7 @@ - gene_reaction_rule: "YOR311C" - eccodes: "2.7.1.174" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00564" @@ -67832,6 +69688,7 @@ - gene_reaction_rule: "YOR311C" - eccodes: "2.7.1.174" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00564" @@ -67855,6 +69712,7 @@ - "2.7.8.1" - "2.7.8.2" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00440" @@ -67879,6 +69737,7 @@ - "2.7.8.1" - "2.7.8.2" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00440" @@ -67903,6 +69762,7 @@ - "2.7.8.1" - "2.7.8.2" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00440" @@ -67927,6 +69787,7 @@ - "2.7.8.1" - "2.7.8.2" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00440" @@ -67951,6 +69812,7 @@ - "2.7.8.1" - "2.7.8.2" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00440" @@ -67975,6 +69837,7 @@ - "2.7.8.1" - "2.7.8.2" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00440" @@ -67999,6 +69862,7 @@ - "2.7.8.1" - "2.7.8.2" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00440" @@ -68023,6 +69887,7 @@ - "2.7.8.1" - "2.7.8.2" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00440" @@ -68047,6 +69912,7 @@ - "2.7.8.1" - "2.7.8.2" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00440" @@ -68071,6 +69937,7 @@ - "2.7.8.1" - "2.7.8.2" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00440" @@ -68095,6 +69962,7 @@ - "2.7.8.1" - "2.7.8.2" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00440" @@ -68119,6 +69987,7 @@ - "2.7.8.1" - "2.7.8.2" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00440" @@ -68143,6 +70012,7 @@ - "2.7.8.1" - "2.7.8.2" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00440" @@ -68167,6 +70037,7 @@ - "2.7.8.1" - "2.7.8.2" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00440" @@ -68191,6 +70062,7 @@ - "2.7.8.1" - "2.7.8.2" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00440" @@ -68215,6 +70087,7 @@ - "2.7.8.1" - "2.7.8.2" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00440" @@ -68236,6 +70109,7 @@ - gene_reaction_rule: "YCL004W" - eccodes: "2.7.8.5" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -68254,6 +70128,7 @@ - gene_reaction_rule: "YCL004W" - eccodes: "2.7.8.5" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -68272,6 +70147,7 @@ - gene_reaction_rule: "YCL004W" - eccodes: "2.7.8.5" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -68290,6 +70166,7 @@ - gene_reaction_rule: "YCL004W" - eccodes: "2.7.8.5" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -68308,6 +70185,7 @@ - gene_reaction_rule: "YCL004W" - eccodes: "2.7.8.5" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -68326,6 +70204,7 @@ - gene_reaction_rule: "YCL004W" - eccodes: "2.7.8.5" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -68345,6 +70224,7 @@ - gene_reaction_rule: "YHR100C" - eccodes: "3.1.3.27" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -68364,6 +70244,7 @@ - gene_reaction_rule: "YHR100C" - eccodes: "3.1.3.27" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -68383,6 +70264,7 @@ - gene_reaction_rule: "YHR100C" - eccodes: "3.1.3.27" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -68402,6 +70284,7 @@ - gene_reaction_rule: "YHR100C" - eccodes: "3.1.3.27" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -68421,6 +70304,7 @@ - gene_reaction_rule: "YHR100C" - eccodes: "3.1.3.27" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -68440,6 +70324,7 @@ - gene_reaction_rule: "YHR100C" - eccodes: "3.1.3.27" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -68459,6 +70344,7 @@ - gene_reaction_rule: "YDL142C" - eccodes: "2.7.8.41" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -68478,6 +70364,7 @@ - gene_reaction_rule: "YDL142C" - eccodes: "2.7.8.41" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -68497,6 +70384,7 @@ - gene_reaction_rule: "YDL142C" - eccodes: "2.7.8.41" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -68516,6 +70404,7 @@ - gene_reaction_rule: "YDL142C" - eccodes: "2.7.8.41" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -68535,6 +70424,7 @@ - gene_reaction_rule: "YDL142C" - eccodes: "2.7.8.41" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -68554,6 +70444,7 @@ - gene_reaction_rule: "YDL142C" - eccodes: "2.7.8.41" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -68573,6 +70464,7 @@ - gene_reaction_rule: "YDL142C" - eccodes: "2.7.8.41" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -68592,6 +70484,7 @@ - gene_reaction_rule: "YDL142C" - eccodes: "2.7.8.41" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -68611,6 +70504,7 @@ - gene_reaction_rule: "YDL142C" - eccodes: "2.7.8.41" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -68630,6 +70524,7 @@ - gene_reaction_rule: "YDL142C" - eccodes: "2.7.8.41" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -68649,6 +70544,7 @@ - gene_reaction_rule: "YDL142C" - eccodes: "2.7.8.41" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -68668,6 +70564,7 @@ - gene_reaction_rule: "YDL142C" - eccodes: "2.7.8.41" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -68687,6 +70584,7 @@ - gene_reaction_rule: "YDL142C" - eccodes: "2.7.8.41" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -68706,6 +70604,7 @@ - gene_reaction_rule: "YDL142C" - eccodes: "2.7.8.41" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -68725,6 +70624,7 @@ - gene_reaction_rule: "YDL142C" - eccodes: "2.7.8.41" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -68744,6 +70644,7 @@ - gene_reaction_rule: "YDL142C" - eccodes: "2.7.8.41" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -68763,6 +70664,7 @@ - gene_reaction_rule: "YDL142C" - eccodes: "2.7.8.41" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -68782,6 +70684,7 @@ - gene_reaction_rule: "YDL142C" - eccodes: "2.7.8.41" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -68801,6 +70704,7 @@ - gene_reaction_rule: "YDL142C" - eccodes: "2.7.8.41" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -68820,6 +70724,7 @@ - gene_reaction_rule: "YDL142C" - eccodes: "2.7.8.41" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -68839,6 +70744,7 @@ - gene_reaction_rule: "YDL142C" - eccodes: "2.7.8.41" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -68858,6 +70764,7 @@ - gene_reaction_rule: "YDL142C" - eccodes: "2.7.8.41" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -68877,6 +70784,7 @@ - gene_reaction_rule: "YDL142C" - eccodes: "2.7.8.41" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -68896,6 +70804,7 @@ - gene_reaction_rule: "YDL142C" - eccodes: "2.7.8.41" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -68915,6 +70824,7 @@ - gene_reaction_rule: "YDL142C" - eccodes: "2.7.8.41" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -68934,6 +70844,7 @@ - gene_reaction_rule: "YDL142C" - eccodes: "2.7.8.41" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -68953,6 +70864,7 @@ - gene_reaction_rule: "YDL142C" - eccodes: "2.7.8.41" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -68972,6 +70884,7 @@ - gene_reaction_rule: "YDL142C" - eccodes: "2.7.8.41" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -68991,6 +70904,7 @@ - gene_reaction_rule: "YDL142C" - eccodes: "2.7.8.41" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -69010,6 +70924,7 @@ - gene_reaction_rule: "YDL142C" - eccodes: "2.7.8.41" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -69029,6 +70944,7 @@ - gene_reaction_rule: "YDL142C" - eccodes: "2.7.8.41" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -69048,6 +70964,7 @@ - gene_reaction_rule: "YDL142C" - eccodes: "2.7.8.41" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -69067,6 +70984,7 @@ - gene_reaction_rule: "YDL142C" - eccodes: "2.7.8.41" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -69086,6 +71004,7 @@ - gene_reaction_rule: "YDL142C" - eccodes: "2.7.8.41" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -69105,6 +71024,7 @@ - gene_reaction_rule: "YDL142C" - eccodes: "2.7.8.41" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -69124,6 +71044,7 @@ - gene_reaction_rule: "YDL142C" - eccodes: "2.7.8.41" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -69143,6 +71064,7 @@ - gene_reaction_rule: "YGR110W" - eccodes: "3.5.1.-" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -69162,6 +71084,7 @@ - gene_reaction_rule: "YGR110W" - eccodes: "3.5.1.-" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -69181,6 +71104,7 @@ - gene_reaction_rule: "YGR110W" - eccodes: "3.5.1.-" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -69200,6 +71124,7 @@ - gene_reaction_rule: "YGR110W" - eccodes: "3.5.1.-" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -69219,6 +71144,7 @@ - gene_reaction_rule: "YGR110W" - eccodes: "3.5.1.-" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -69238,6 +71164,7 @@ - gene_reaction_rule: "YGR110W" - eccodes: "3.5.1.-" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -69257,6 +71184,7 @@ - gene_reaction_rule: "YGR110W" - eccodes: "3.5.1.-" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -69276,6 +71204,7 @@ - gene_reaction_rule: "YGR110W" - eccodes: "3.5.1.-" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -69295,6 +71224,7 @@ - gene_reaction_rule: "YGR110W" - eccodes: "3.5.1.-" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -69314,6 +71244,7 @@ - gene_reaction_rule: "YGR110W" - eccodes: "3.5.1.-" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -69333,6 +71264,7 @@ - gene_reaction_rule: "YGR110W" - eccodes: "3.5.1.-" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -69352,6 +71284,7 @@ - gene_reaction_rule: "YGR110W" - eccodes: "3.5.1.-" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -69371,6 +71304,7 @@ - gene_reaction_rule: "YGR110W" - eccodes: "3.5.1.-" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -69390,6 +71324,7 @@ - gene_reaction_rule: "YGR110W" - eccodes: "3.5.1.-" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -69409,6 +71344,7 @@ - gene_reaction_rule: "YGR110W" - eccodes: "3.5.1.-" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -69428,6 +71364,7 @@ - gene_reaction_rule: "YGR110W" - eccodes: "3.5.1.-" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -69447,6 +71384,7 @@ - gene_reaction_rule: "YGR110W" - eccodes: "3.5.1.-" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -69466,6 +71404,7 @@ - gene_reaction_rule: "YGR110W" - eccodes: "3.5.1.-" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -69485,6 +71424,7 @@ - gene_reaction_rule: "YGR110W" - eccodes: "3.5.1.-" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -69504,6 +71444,7 @@ - gene_reaction_rule: "YGR110W" - eccodes: "3.5.1.-" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -69523,6 +71464,7 @@ - gene_reaction_rule: "YGR110W" - eccodes: "3.5.1.-" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -69542,6 +71484,7 @@ - gene_reaction_rule: "YGR110W" - eccodes: "3.5.1.-" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -69561,6 +71504,7 @@ - gene_reaction_rule: "YGR110W" - eccodes: "3.5.1.-" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -69580,6 +71524,7 @@ - gene_reaction_rule: "YGR110W" - eccodes: "3.5.1.-" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -69599,6 +71544,7 @@ - gene_reaction_rule: "YGR110W" - eccodes: "3.5.1.-" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -69618,6 +71564,7 @@ - gene_reaction_rule: "YGR110W" - eccodes: "3.5.1.-" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -69637,6 +71584,7 @@ - gene_reaction_rule: "YGR110W" - eccodes: "3.5.1.-" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -69656,6 +71604,7 @@ - gene_reaction_rule: "YGR110W" - eccodes: "3.5.1.-" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -69675,6 +71624,7 @@ - gene_reaction_rule: "YGR110W" - eccodes: "3.5.1.-" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -69694,6 +71644,7 @@ - gene_reaction_rule: "YGR110W" - eccodes: "3.5.1.-" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -69713,6 +71664,7 @@ - gene_reaction_rule: "YGR110W" - eccodes: "3.5.1.-" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -69732,6 +71684,7 @@ - gene_reaction_rule: "YGR110W" - eccodes: "3.5.1.-" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -69751,6 +71704,7 @@ - gene_reaction_rule: "YGR110W" - eccodes: "3.5.1.-" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -69770,6 +71724,7 @@ - gene_reaction_rule: "YGR110W" - eccodes: "3.5.1.-" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -69789,6 +71744,7 @@ - gene_reaction_rule: "YGR110W" - eccodes: "3.5.1.-" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -69808,6 +71764,7 @@ - gene_reaction_rule: "YGR110W" - eccodes: "3.5.1.-" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -69826,6 +71783,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -69844,6 +71802,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -69862,6 +71821,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -69880,6 +71840,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -69898,6 +71859,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -69916,6 +71878,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -69934,6 +71897,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -69952,6 +71916,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -69970,6 +71935,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -69988,6 +71954,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -70006,6 +71973,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -70024,6 +71992,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -70042,6 +72011,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -70060,6 +72030,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -70078,6 +72049,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -70096,6 +72068,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -70114,6 +72087,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -70132,6 +72106,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -70150,6 +72125,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -70168,6 +72144,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -70186,6 +72163,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -70204,6 +72182,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -70222,6 +72201,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -70240,6 +72220,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -70258,6 +72239,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -70276,6 +72258,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -70294,6 +72277,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -70312,6 +72296,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -70330,6 +72315,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -70348,6 +72334,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -70366,6 +72353,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -70384,6 +72372,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -70402,6 +72391,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -70420,6 +72410,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -70438,6 +72429,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -70456,6 +72448,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -70474,6 +72467,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -70492,6 +72486,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -70510,6 +72505,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -70528,6 +72524,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -70546,6 +72543,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -70564,6 +72562,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -70582,6 +72581,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -70600,6 +72600,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -70618,6 +72619,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -70636,6 +72638,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -70654,6 +72657,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -70672,6 +72676,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -70690,6 +72695,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -70708,6 +72714,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -70726,6 +72733,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -70744,6 +72752,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -70762,6 +72771,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -70780,6 +72790,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -70798,6 +72809,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -70816,6 +72828,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -70834,6 +72847,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -70852,6 +72866,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -70870,6 +72885,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -70888,6 +72904,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -70906,6 +72923,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -70924,6 +72942,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -70942,6 +72961,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -70960,6 +72980,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -70978,6 +72999,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -70996,6 +73018,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -71014,6 +73037,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -71032,6 +73056,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -71050,6 +73075,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -71068,6 +73094,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -71086,6 +73113,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -71104,6 +73132,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -71122,6 +73151,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -71140,6 +73170,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -71158,6 +73189,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -71176,6 +73208,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -71194,6 +73227,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -71212,6 +73246,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -71230,6 +73265,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -71248,6 +73284,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -71266,6 +73303,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -71284,6 +73322,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -71302,6 +73341,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -71320,6 +73360,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -71338,6 +73379,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -71356,6 +73398,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -71374,6 +73417,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -71392,6 +73436,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -71410,6 +73455,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -71428,6 +73474,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -71446,6 +73493,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -71464,6 +73512,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -71482,6 +73531,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -71500,6 +73550,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -71518,6 +73569,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -71536,6 +73588,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -71554,6 +73607,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -71572,6 +73626,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -71590,6 +73645,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -71608,6 +73664,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -71626,6 +73683,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -71644,6 +73702,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -71662,6 +73721,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -71680,6 +73740,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -71698,6 +73759,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -71716,6 +73778,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -71734,6 +73797,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -71752,6 +73816,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -71770,6 +73835,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -71788,6 +73854,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -71806,6 +73873,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -71824,6 +73892,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -71842,6 +73911,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -71860,6 +73930,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -71878,6 +73949,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -71896,6 +73968,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -71914,6 +73987,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -71932,6 +74006,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -71950,6 +74025,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -71968,6 +74044,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -71986,6 +74063,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -72004,6 +74082,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -72022,6 +74101,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -72040,6 +74120,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -72058,6 +74139,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -72076,6 +74158,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -72094,6 +74177,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -72112,6 +74196,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -72130,6 +74215,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -72148,6 +74234,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -72166,6 +74253,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -72184,6 +74272,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -72202,6 +74291,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -72220,6 +74310,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -72238,6 +74329,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -72256,6 +74348,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -72274,6 +74367,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -72292,6 +74386,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -72310,6 +74405,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -72328,6 +74424,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -72346,6 +74443,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -72364,6 +74462,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -72382,6 +74481,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -72400,6 +74500,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -72418,6 +74519,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -72436,6 +74538,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -72454,6 +74557,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -72472,6 +74576,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -72490,6 +74595,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -72508,6 +74614,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -72526,6 +74633,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -72544,6 +74652,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -72562,6 +74671,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -72580,6 +74690,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -72598,6 +74709,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -72616,6 +74728,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -72634,6 +74747,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -72652,6 +74766,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -72670,6 +74785,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -72688,6 +74804,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -72706,6 +74823,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -72724,6 +74842,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -72742,6 +74861,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -72760,6 +74880,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -72778,6 +74899,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -72796,6 +74918,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -72814,6 +74937,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -72832,6 +74956,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -72850,6 +74975,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -72868,6 +74994,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -72886,6 +75013,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -72904,6 +75032,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -72922,6 +75051,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -72940,6 +75070,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -72958,6 +75089,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -72976,6 +75108,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -72994,6 +75127,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -73012,6 +75146,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -73030,6 +75165,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -73048,6 +75184,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -73066,6 +75203,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -73084,6 +75222,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -73102,6 +75241,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -73120,6 +75260,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -73138,6 +75279,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -73156,6 +75298,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -73174,6 +75317,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -73192,6 +75336,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -73210,6 +75355,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -73228,6 +75374,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -73246,6 +75393,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -73264,6 +75412,7 @@ - gene_reaction_rule: "YPR140W" - eccodes: "2.3.1.23" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -73280,6 +75429,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - sbo: "SBO:0000176" - confidence_score: 0 @@ -73294,6 +75444,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - sbo: "SBO:0000176" - confidence_score: 0 @@ -73308,6 +75459,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - sbo: "SBO:0000176" - confidence_score: 0 @@ -73322,6 +75474,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - sbo: "SBO:0000176" - confidence_score: 0 @@ -73336,6 +75489,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - sbo: "SBO:0000176" - confidence_score: 0 @@ -73350,6 +75504,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - sbo: "SBO:0000176" - confidence_score: 0 @@ -73364,6 +75519,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - sbo: "SBO:0000176" - confidence_score: 0 @@ -73378,6 +75534,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - sbo: "SBO:0000176" - confidence_score: 0 @@ -73395,6 +75552,7 @@ - gene_reaction_rule: "YJL100W or YLR305C" - eccodes: "2.7.1.67" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -73417,6 +75575,7 @@ - gene_reaction_rule: "YJL100W or YLR305C" - eccodes: "2.7.1.67" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -73439,6 +75598,7 @@ - gene_reaction_rule: "YJL100W or YLR305C" - eccodes: "2.7.1.67" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -73461,6 +75621,7 @@ - gene_reaction_rule: "YJL100W or YLR305C" - eccodes: "2.7.1.67" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -73483,6 +75644,7 @@ - gene_reaction_rule: "YJL100W or YLR305C" - eccodes: "2.7.1.67" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -73505,6 +75667,7 @@ - gene_reaction_rule: "YJL100W or YLR305C" - eccodes: "2.7.1.67" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -73527,6 +75690,7 @@ - gene_reaction_rule: "YJL100W or YLR305C" - eccodes: "2.7.1.67" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -73549,6 +75713,7 @@ - gene_reaction_rule: "YJL100W or YLR305C" - eccodes: "2.7.1.67" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -73571,6 +75736,7 @@ - gene_reaction_rule: "YJL100W" - eccodes: "2.7.1.67" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -73592,6 +75758,7 @@ - gene_reaction_rule: "YJL100W" - eccodes: "2.7.1.67" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -73613,6 +75780,7 @@ - gene_reaction_rule: "YJL100W" - eccodes: "2.7.1.67" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -73634,6 +75802,7 @@ - gene_reaction_rule: "YJL100W" - eccodes: "2.7.1.67" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -73655,6 +75824,7 @@ - gene_reaction_rule: "YJL100W" - eccodes: "2.7.1.67" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -73676,6 +75846,7 @@ - gene_reaction_rule: "YJL100W" - eccodes: "2.7.1.67" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -73697,6 +75868,7 @@ - gene_reaction_rule: "YJL100W" - eccodes: "2.7.1.67" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -73718,6 +75890,7 @@ - gene_reaction_rule: "YJL100W" - eccodes: "2.7.1.67" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -73739,6 +75912,7 @@ - gene_reaction_rule: "YDR373W and YNL267W" - eccodes: "2.7.1.67" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -73760,6 +75934,7 @@ - gene_reaction_rule: "YDR373W and YNL267W" - eccodes: "2.7.1.67" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -73781,6 +75956,7 @@ - gene_reaction_rule: "YDR373W and YNL267W" - eccodes: "2.7.1.67" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -73802,6 +75978,7 @@ - gene_reaction_rule: "YDR373W and YNL267W" - eccodes: "2.7.1.67" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -73823,6 +76000,7 @@ - gene_reaction_rule: "YDR373W and YNL267W" - eccodes: "2.7.1.67" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -73844,6 +76022,7 @@ - gene_reaction_rule: "YDR373W and YNL267W" - eccodes: "2.7.1.67" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -73865,6 +76044,7 @@ - gene_reaction_rule: "YDR373W and YNL267W" - eccodes: "2.7.1.67" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -73886,6 +76066,7 @@ - gene_reaction_rule: "YDR373W and YNL267W" - eccodes: "2.7.1.67" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -73907,6 +76088,7 @@ - gene_reaction_rule: "YNL267W" - eccodes: "2.7.1.67" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -73928,6 +76110,7 @@ - gene_reaction_rule: "YNL267W" - eccodes: "2.7.1.67" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -73949,6 +76132,7 @@ - gene_reaction_rule: "YNL267W" - eccodes: "2.7.1.67" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -73970,6 +76154,7 @@ - gene_reaction_rule: "YNL267W" - eccodes: "2.7.1.67" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -73991,6 +76176,7 @@ - gene_reaction_rule: "YNL267W" - eccodes: "2.7.1.67" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -74012,6 +76198,7 @@ - gene_reaction_rule: "YNL267W" - eccodes: "2.7.1.67" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -74033,6 +76220,7 @@ - gene_reaction_rule: "YNL267W" - eccodes: "2.7.1.67" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -74054,6 +76242,7 @@ - gene_reaction_rule: "YNL267W" - eccodes: "2.7.1.67" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -74072,11 +76261,12 @@ - s_3392: 1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "YBR097W and YLR240W" + - gene_reaction_rule: "(YBR097W and YLR240W) or (YBR097W and YLR240W and YPL120W and YLR360W) or (YBR097W and YLR240W and YBR128C and YPL120W and YLR211C)" - eccodes: - "2.7.1.137" - "2.7.11.1" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -74098,11 +76288,12 @@ - s_3393: 1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "YBR097W and YLR240W" + - gene_reaction_rule: "(YBR097W and YLR240W) or (YBR097W and YLR240W and YPL120W and YLR360W) or (YBR097W and YLR240W and YBR128C and YPL120W and YLR211C)" - eccodes: - "2.7.1.137" - "2.7.11.1" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -74124,11 +76315,12 @@ - s_3394: 1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "YBR097W and YLR240W" + - gene_reaction_rule: "(YBR097W and YLR240W) or (YBR097W and YLR240W and YPL120W and YLR360W) or (YBR097W and YLR240W and YBR128C and YPL120W and YLR211C)" - eccodes: - "2.7.1.137" - "2.7.11.1" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -74150,11 +76342,12 @@ - s_3395: 1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "YBR097W and YLR240W" + - gene_reaction_rule: "(YBR097W and YLR240W) or (YBR097W and YLR240W and YPL120W and YLR360W) or (YBR097W and YLR240W and YBR128C and YPL120W and YLR211C)" - eccodes: - "2.7.1.137" - "2.7.11.1" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -74176,11 +76369,12 @@ - s_3396: 1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "YBR097W and YLR240W" + - gene_reaction_rule: "(YBR097W and YLR240W) or (YBR097W and YLR240W and YPL120W and YLR360W) or (YBR097W and YLR240W and YBR128C and YPL120W and YLR211C)" - eccodes: - "2.7.1.137" - "2.7.11.1" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -74202,11 +76396,12 @@ - s_3397: 1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "YBR097W and YLR240W" + - gene_reaction_rule: "(YBR097W and YLR240W) or (YBR097W and YLR240W and YPL120W and YLR360W) or (YBR097W and YLR240W and YBR128C and YPL120W and YLR211C)" - eccodes: - "2.7.1.137" - "2.7.11.1" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -74228,11 +76423,12 @@ - s_3398: 1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "YBR097W and YLR240W" + - gene_reaction_rule: "(YBR097W and YLR240W) or (YBR097W and YLR240W and YPL120W and YLR360W) or (YBR097W and YLR240W and YBR128C and YPL120W and YLR211C)" - eccodes: - "2.7.1.137" - "2.7.11.1" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -74254,11 +76450,12 @@ - s_3399: 1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "YBR097W and YLR240W" + - gene_reaction_rule: "(YBR097W and YLR240W) or (YBR097W and YLR240W and YPL120W and YLR360W) or (YBR097W and YLR240W and YBR128C and YPL120W and YLR211C)" - eccodes: - "2.7.1.137" - "2.7.11.1" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -74283,6 +76480,7 @@ - gene_reaction_rule: "YDR208W" - eccodes: "2.7.1.68" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -74307,6 +76505,7 @@ - gene_reaction_rule: "YDR208W" - eccodes: "2.7.1.68" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -74331,6 +76530,7 @@ - gene_reaction_rule: "YDR208W" - eccodes: "2.7.1.68" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -74355,6 +76555,7 @@ - gene_reaction_rule: "YDR208W" - eccodes: "2.7.1.68" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -74379,6 +76580,7 @@ - gene_reaction_rule: "YDR208W" - eccodes: "2.7.1.68" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -74403,6 +76605,7 @@ - gene_reaction_rule: "YDR208W" - eccodes: "2.7.1.68" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -74427,6 +76630,7 @@ - gene_reaction_rule: "YDR208W" - eccodes: "2.7.1.68" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -74451,6 +76655,7 @@ - gene_reaction_rule: "YDR208W" - eccodes: "2.7.1.68" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -74475,6 +76680,7 @@ - gene_reaction_rule: "YDR208W" - eccodes: "2.7.1.68" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -74499,6 +76705,7 @@ - gene_reaction_rule: "YDR208W" - eccodes: "2.7.1.68" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -74523,6 +76730,7 @@ - gene_reaction_rule: "YDR208W" - eccodes: "2.7.1.68" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -74547,6 +76755,7 @@ - gene_reaction_rule: "YDR208W" - eccodes: "2.7.1.68" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -74571,6 +76780,7 @@ - gene_reaction_rule: "YDR208W" - eccodes: "2.7.1.68" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -74595,6 +76805,7 @@ - gene_reaction_rule: "YDR208W" - eccodes: "2.7.1.68" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -74619,6 +76830,7 @@ - gene_reaction_rule: "YDR208W" - eccodes: "2.7.1.68" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -74643,6 +76855,7 @@ - gene_reaction_rule: "YDR208W" - eccodes: "2.7.1.68" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -74667,6 +76880,7 @@ - gene_reaction_rule: "YFR019W" - eccodes: "2.7.1.150" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -74689,6 +76903,7 @@ - gene_reaction_rule: "YFR019W" - eccodes: "2.7.1.150" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -74711,6 +76926,7 @@ - gene_reaction_rule: "YFR019W" - eccodes: "2.7.1.150" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -74733,6 +76949,7 @@ - gene_reaction_rule: "YFR019W" - eccodes: "2.7.1.150" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -74755,6 +76972,7 @@ - gene_reaction_rule: "YFR019W" - eccodes: "2.7.1.150" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -74777,6 +76995,7 @@ - gene_reaction_rule: "YFR019W" - eccodes: "2.7.1.150" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -74799,6 +77018,7 @@ - gene_reaction_rule: "YFR019W" - eccodes: "2.7.1.150" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -74821,6 +77041,7 @@ - gene_reaction_rule: "YFR019W" - eccodes: "2.7.1.150" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -74842,6 +77063,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -74860,6 +77082,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -74878,6 +77101,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -74896,6 +77120,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -74914,6 +77139,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -74932,6 +77158,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -74950,6 +77177,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -74968,6 +77196,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -74986,6 +77215,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -75004,6 +77234,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -75022,6 +77253,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -75040,6 +77272,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -75058,6 +77291,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -75076,6 +77310,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -75094,6 +77329,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -75112,6 +77348,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -75130,6 +77367,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -75148,6 +77386,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -75166,6 +77405,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -75184,6 +77424,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -75202,6 +77443,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -75220,6 +77462,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -75238,6 +77481,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -75256,6 +77500,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -75274,6 +77519,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -75292,6 +77538,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -75310,6 +77557,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -75328,6 +77576,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -75346,6 +77595,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -75364,6 +77614,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -75382,6 +77633,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -75400,6 +77652,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -75418,6 +77671,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -75436,6 +77690,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -75454,6 +77709,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -75472,6 +77728,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -75490,6 +77747,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -75508,6 +77766,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -75526,6 +77785,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -75544,6 +77804,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -75562,6 +77823,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -75580,6 +77842,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -75598,6 +77861,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -75616,6 +77880,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -75634,6 +77899,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -75652,6 +77918,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -75670,6 +77937,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -75688,6 +77956,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -75706,6 +77975,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -75724,6 +77994,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -75742,6 +78013,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -75760,6 +78032,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -75778,6 +78051,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -75796,6 +78070,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -75814,6 +78089,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -75832,6 +78108,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -75850,6 +78127,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -75868,6 +78146,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -75886,6 +78165,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -75904,6 +78184,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -75922,6 +78203,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -75940,6 +78222,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -75958,6 +78241,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -75976,6 +78260,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -75994,6 +78279,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -76012,6 +78298,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -76030,6 +78317,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -76048,6 +78336,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -76066,6 +78355,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -76084,6 +78374,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -76102,6 +78393,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -76120,6 +78412,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -76138,6 +78431,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -76156,6 +78450,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -76174,6 +78469,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -76192,6 +78488,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -76210,6 +78507,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -76228,6 +78526,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -76246,6 +78545,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -76264,6 +78564,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -76282,6 +78583,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -76300,6 +78602,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -76318,6 +78621,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -76336,6 +78640,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -76354,6 +78659,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -76372,6 +78678,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -76390,6 +78697,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -76408,6 +78716,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -76426,6 +78735,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -76444,6 +78754,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -76462,6 +78773,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -76480,6 +78792,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -76498,6 +78811,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -76516,6 +78830,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -76534,6 +78849,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -76552,6 +78868,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -76570,6 +78887,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -76588,6 +78906,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -76606,6 +78925,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -76624,6 +78944,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -76642,6 +78963,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -76660,6 +78982,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -76678,6 +79001,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -76696,6 +79020,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -76714,6 +79039,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -76732,6 +79058,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -76750,6 +79077,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -76768,6 +79096,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -76786,6 +79115,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -76804,6 +79134,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -76822,6 +79153,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -76840,6 +79172,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -76858,6 +79191,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -76876,6 +79210,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -76894,6 +79229,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -76912,6 +79248,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -76930,6 +79267,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -76948,6 +79286,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -76966,6 +79305,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -76984,6 +79324,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -77002,6 +79343,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -77020,6 +79362,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -77038,6 +79381,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -77056,6 +79400,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -77074,6 +79419,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -77092,6 +79438,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -77110,6 +79457,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -77128,6 +79476,7 @@ - gene_reaction_rule: "YNR008W" - eccodes: "2.3.1.158" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -77147,6 +79496,7 @@ - gene_reaction_rule: "YML059C" - eccodes: "3.1.1.5" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -77166,6 +79516,7 @@ - gene_reaction_rule: "YML059C" - eccodes: "3.1.1.5" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -77185,6 +79536,7 @@ - gene_reaction_rule: "YML059C" - eccodes: "3.1.1.5" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -77204,6 +79556,7 @@ - gene_reaction_rule: "YML059C" - eccodes: "3.1.1.5" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -77223,6 +79576,7 @@ - gene_reaction_rule: "YML059C" - eccodes: "3.1.1.5" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -77242,6 +79596,7 @@ - gene_reaction_rule: "YML059C" - eccodes: "3.1.1.5" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -77261,6 +79616,7 @@ - gene_reaction_rule: "YML059C" - eccodes: "3.1.1.5" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -77280,6 +79636,7 @@ - gene_reaction_rule: "YML059C" - eccodes: "3.1.1.5" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -77299,6 +79656,7 @@ - gene_reaction_rule: "YML059C" - eccodes: "3.1.1.5" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -77318,6 +79676,7 @@ - gene_reaction_rule: "YML059C" - eccodes: "3.1.1.5" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -77337,6 +79696,7 @@ - gene_reaction_rule: "YML059C" - eccodes: "3.1.1.5" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -77356,6 +79716,7 @@ - gene_reaction_rule: "YML059C" - eccodes: "3.1.1.5" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -77375,6 +79736,7 @@ - gene_reaction_rule: "YMR008C" - eccodes: "3.1.1.5" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -77394,6 +79756,7 @@ - gene_reaction_rule: "YMR008C" - eccodes: "3.1.1.5" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -77413,6 +79776,7 @@ - gene_reaction_rule: "YMR008C" - eccodes: "3.1.1.5" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -77432,6 +79796,7 @@ - gene_reaction_rule: "YMR008C" - eccodes: "3.1.1.5" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -77451,6 +79816,7 @@ - gene_reaction_rule: "YMR008C" - eccodes: "3.1.1.5" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -77470,6 +79836,7 @@ - gene_reaction_rule: "YMR008C" - eccodes: "3.1.1.5" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -77489,6 +79856,7 @@ - gene_reaction_rule: "YMR008C" - eccodes: "3.1.1.5" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -77508,6 +79876,7 @@ - gene_reaction_rule: "YMR008C" - eccodes: "3.1.1.5" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -77527,6 +79896,7 @@ - gene_reaction_rule: "YMR008C" - eccodes: "3.1.1.5" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -77546,6 +79916,7 @@ - gene_reaction_rule: "YMR008C" - eccodes: "3.1.1.5" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -77565,6 +79936,7 @@ - gene_reaction_rule: "YMR008C" - eccodes: "3.1.1.5" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -77584,6 +79956,7 @@ - gene_reaction_rule: "YMR008C" - eccodes: "3.1.1.5" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -77603,6 +79976,7 @@ - gene_reaction_rule: "YMR006C or YMR008C" - eccodes: "3.1.1.5" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -77622,6 +79996,7 @@ - gene_reaction_rule: "YMR006C or YMR008C" - eccodes: "3.1.1.5" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -77641,6 +80016,7 @@ - gene_reaction_rule: "YMR006C or YMR008C" - eccodes: "3.1.1.5" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -77660,6 +80036,7 @@ - gene_reaction_rule: "YMR006C or YMR008C" - eccodes: "3.1.1.5" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -77679,6 +80056,7 @@ - gene_reaction_rule: "YMR006C or YMR008C" - eccodes: "3.1.1.5" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -77698,6 +80076,7 @@ - gene_reaction_rule: "YMR006C or YMR008C" - eccodes: "3.1.1.5" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -77717,6 +80096,7 @@ - gene_reaction_rule: "YMR006C or YMR008C" - eccodes: "3.1.1.5" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -77736,6 +80116,7 @@ - gene_reaction_rule: "YMR006C or YMR008C" - eccodes: "3.1.1.5" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -77755,6 +80136,7 @@ - gene_reaction_rule: "YMR006C or YMR008C" - eccodes: "3.1.1.5" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -77774,6 +80156,7 @@ - gene_reaction_rule: "YMR006C or YMR008C" - eccodes: "3.1.1.5" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -77793,6 +80176,7 @@ - gene_reaction_rule: "YMR006C or YMR008C" - eccodes: "3.1.1.5" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -77812,6 +80196,7 @@ - gene_reaction_rule: "YMR006C or YMR008C" - eccodes: "3.1.1.5" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -77831,6 +80216,7 @@ - gene_reaction_rule: "YMR006C or YOL011W" - eccodes: "3.1.1.5" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -77850,6 +80236,7 @@ - gene_reaction_rule: "YMR006C or YOL011W" - eccodes: "3.1.1.5" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -77869,6 +80256,7 @@ - gene_reaction_rule: "YMR006C or YOL011W" - eccodes: "3.1.1.5" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -77888,6 +80276,7 @@ - gene_reaction_rule: "YMR006C or YOL011W" - eccodes: "3.1.1.5" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -77907,6 +80296,7 @@ - gene_reaction_rule: "YMR006C or YOL011W" - eccodes: "3.1.1.5" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -77926,6 +80316,7 @@ - gene_reaction_rule: "YMR006C or YOL011W" - eccodes: "3.1.1.5" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -77945,6 +80336,7 @@ - gene_reaction_rule: "YMR006C or YOL011W" - eccodes: "3.1.1.5" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -77964,6 +80356,7 @@ - gene_reaction_rule: "YMR006C or YOL011W" - eccodes: "3.1.1.5" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -77983,6 +80376,7 @@ - gene_reaction_rule: "YMR006C or YOL011W" - eccodes: "3.1.1.5" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -78002,6 +80396,7 @@ - gene_reaction_rule: "YMR006C or YOL011W" - eccodes: "3.1.1.5" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -78021,6 +80416,7 @@ - gene_reaction_rule: "YMR006C or YOL011W" - eccodes: "3.1.1.5" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -78040,6 +80436,7 @@ - gene_reaction_rule: "YMR006C or YOL011W" - eccodes: "3.1.1.5" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -78059,6 +80456,7 @@ - gene_reaction_rule: "YOL011W" - eccodes: "3.1.1.5" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -78078,6 +80476,7 @@ - gene_reaction_rule: "YOL011W" - eccodes: "3.1.1.5" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -78097,6 +80496,7 @@ - gene_reaction_rule: "YOL011W" - eccodes: "3.1.1.5" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -78116,6 +80516,7 @@ - gene_reaction_rule: "YOL011W" - eccodes: "3.1.1.5" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -78135,6 +80536,7 @@ - gene_reaction_rule: "YOL011W" - eccodes: "3.1.1.5" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -78154,6 +80556,7 @@ - gene_reaction_rule: "YOL011W" - eccodes: "3.1.1.5" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -78173,6 +80576,7 @@ - gene_reaction_rule: "YOL011W" - eccodes: "3.1.1.5" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -78192,6 +80596,7 @@ - gene_reaction_rule: "YOL011W" - eccodes: "3.1.1.5" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -78211,6 +80616,7 @@ - gene_reaction_rule: "YOL011W" - eccodes: "3.1.1.5" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -78230,6 +80636,7 @@ - gene_reaction_rule: "YOL011W" - eccodes: "3.1.1.5" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -78249,6 +80656,7 @@ - gene_reaction_rule: "YOL011W" - eccodes: "3.1.1.5" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -78268,6 +80676,7 @@ - gene_reaction_rule: "YOL011W" - eccodes: "3.1.1.5" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -78287,6 +80696,7 @@ - gene_reaction_rule: "YPL268W" - eccodes: "3.1.4.11" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -78309,6 +80719,7 @@ - gene_reaction_rule: "YPL268W" - eccodes: "3.1.4.11" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -78331,6 +80742,7 @@ - gene_reaction_rule: "YPL268W" - eccodes: "3.1.4.11" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -78353,6 +80765,7 @@ - gene_reaction_rule: "YPL268W" - eccodes: "3.1.4.11" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -78375,6 +80788,7 @@ - gene_reaction_rule: "YPL268W" - eccodes: "3.1.4.11" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -78397,6 +80811,7 @@ - gene_reaction_rule: "YPL268W" - eccodes: "3.1.4.11" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -78419,6 +80834,7 @@ - gene_reaction_rule: "YPL268W" - eccodes: "3.1.4.11" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -78441,6 +80857,7 @@ - gene_reaction_rule: "YPL268W" - eccodes: "3.1.4.11" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -78463,6 +80880,7 @@ - gene_reaction_rule: "YPL268W" - eccodes: "3.1.4.11" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -78485,6 +80903,7 @@ - gene_reaction_rule: "YPL268W" - eccodes: "3.1.4.11" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -78507,6 +80926,7 @@ - gene_reaction_rule: "YPL268W" - eccodes: "3.1.4.11" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -78529,6 +80949,7 @@ - gene_reaction_rule: "YPL268W" - eccodes: "3.1.4.11" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -78551,6 +80972,7 @@ - gene_reaction_rule: "YPL268W" - eccodes: "3.1.4.11" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -78573,6 +80995,7 @@ - gene_reaction_rule: "YPL268W" - eccodes: "3.1.4.11" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -78595,6 +81018,7 @@ - gene_reaction_rule: "YPL268W" - eccodes: "3.1.4.11" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -78617,6 +81041,7 @@ - gene_reaction_rule: "YPL268W" - eccodes: "3.1.4.11" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -78639,6 +81064,7 @@ - gene_reaction_rule: "YPL206C" - eccodes: "3.1.4.-" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -78658,6 +81084,7 @@ - gene_reaction_rule: "YPL206C" - eccodes: "3.1.4.-" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -78677,6 +81104,7 @@ - gene_reaction_rule: "YPL206C" - eccodes: "3.1.4.-" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -78696,6 +81124,7 @@ - gene_reaction_rule: "YPL206C" - eccodes: "3.1.4.-" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -78715,6 +81144,7 @@ - gene_reaction_rule: "YPL206C" - eccodes: "3.1.4.-" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -78734,6 +81164,7 @@ - gene_reaction_rule: "YPL206C" - eccodes: "3.1.4.-" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: "sce00564" - pubmed: "22345606" @@ -78753,6 +81184,7 @@ - gene_reaction_rule: "YKR031C" - eccodes: "3.1.4.4" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00564" @@ -78775,6 +81207,7 @@ - gene_reaction_rule: "YKR031C" - eccodes: "3.1.4.4" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00564" @@ -78797,6 +81230,7 @@ - gene_reaction_rule: "YKR031C" - eccodes: "3.1.4.4" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00564" @@ -78819,6 +81253,7 @@ - gene_reaction_rule: "YKR031C" - eccodes: "3.1.4.4" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00564" @@ -78841,6 +81276,7 @@ - gene_reaction_rule: "YKR031C" - eccodes: "3.1.4.4" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00564" @@ -78863,6 +81299,7 @@ - gene_reaction_rule: "YKR031C" - eccodes: "3.1.4.4" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00564" @@ -78885,6 +81322,7 @@ - gene_reaction_rule: "YKR031C" - eccodes: "3.1.4.4" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00564" @@ -78907,6 +81345,7 @@ - gene_reaction_rule: "YKR031C" - eccodes: "3.1.4.4" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00564" @@ -78931,6 +81370,7 @@ - "3.1.3.-" - "3.1.3.36" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -78954,6 +81394,7 @@ - "3.1.3.-" - "3.1.3.36" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -78977,6 +81418,7 @@ - "3.1.3.-" - "3.1.3.36" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -79000,6 +81442,7 @@ - "3.1.3.-" - "3.1.3.36" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -79023,6 +81466,7 @@ - "3.1.3.-" - "3.1.3.36" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -79046,6 +81490,7 @@ - "3.1.3.-" - "3.1.3.36" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -79069,6 +81514,7 @@ - "3.1.3.-" - "3.1.3.36" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -79092,6 +81538,7 @@ - "3.1.3.-" - "3.1.3.36" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -79116,6 +81563,7 @@ - "3.1.3.36" - "3.1.3.64" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -79141,6 +81589,7 @@ - "3.1.3.36" - "3.1.3.64" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - bigg.reaction: "PIP3P_HDE_HDE_c" - kegg.pathway: @@ -79167,6 +81616,7 @@ - "3.1.3.36" - "3.1.3.64" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -79192,6 +81642,7 @@ - "3.1.3.36" - "3.1.3.64" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -79217,6 +81668,7 @@ - "3.1.3.36" - "3.1.3.64" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -79242,6 +81694,7 @@ - "3.1.3.36" - "3.1.3.64" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -79267,6 +81720,7 @@ - "3.1.3.36" - "3.1.3.64" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -79292,6 +81746,7 @@ - "3.1.3.36" - "3.1.3.64" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -79314,6 +81769,7 @@ - gene_reaction_rule: "YKL212W" - eccodes: "3.1.3.-" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -79335,6 +81791,7 @@ - gene_reaction_rule: "YKL212W" - eccodes: "3.1.3.-" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -79356,6 +81813,7 @@ - gene_reaction_rule: "YKL212W" - eccodes: "3.1.3.-" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -79377,6 +81835,7 @@ - gene_reaction_rule: "YKL212W" - eccodes: "3.1.3.-" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -79398,6 +81857,7 @@ - gene_reaction_rule: "YKL212W" - eccodes: "3.1.3.-" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -79419,6 +81879,7 @@ - gene_reaction_rule: "YKL212W" - eccodes: "3.1.3.-" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -79440,6 +81901,7 @@ - gene_reaction_rule: "YKL212W" - eccodes: "3.1.3.-" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -79461,6 +81923,7 @@ - gene_reaction_rule: "YKL212W" - eccodes: "3.1.3.-" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -79482,6 +81945,7 @@ - gene_reaction_rule: "YKL212W" - eccodes: "3.1.3.-" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -79503,6 +81967,7 @@ - gene_reaction_rule: "YKL212W" - eccodes: "3.1.3.-" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -79524,6 +81989,7 @@ - gene_reaction_rule: "YKL212W" - eccodes: "3.1.3.-" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -79545,6 +82011,7 @@ - gene_reaction_rule: "YKL212W" - eccodes: "3.1.3.-" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -79566,6 +82033,7 @@ - gene_reaction_rule: "YKL212W" - eccodes: "3.1.3.-" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -79587,6 +82055,7 @@ - gene_reaction_rule: "YKL212W" - eccodes: "3.1.3.-" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -79608,6 +82077,7 @@ - gene_reaction_rule: "YKL212W" - eccodes: "3.1.3.-" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -79629,6 +82099,7 @@ - gene_reaction_rule: "YKL212W" - eccodes: "3.1.3.-" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -79652,6 +82123,7 @@ - "3.1.3.-" - "3.1.3.36" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -79675,6 +82147,7 @@ - "3.1.3.-" - "3.1.3.36" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -79698,6 +82171,7 @@ - "3.1.3.-" - "3.1.3.36" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -79721,6 +82195,7 @@ - "3.1.3.-" - "3.1.3.36" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -79744,6 +82219,7 @@ - "3.1.3.-" - "3.1.3.36" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -79767,6 +82243,7 @@ - "3.1.3.-" - "3.1.3.36" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -79790,6 +82267,7 @@ - "3.1.3.-" - "3.1.3.36" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -79813,6 +82291,7 @@ - "3.1.3.-" - "3.1.3.36" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -79836,6 +82315,7 @@ - "3.1.3.-" - "3.1.3.36" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -79859,6 +82339,7 @@ - "3.1.3.-" - "3.1.3.36" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -79882,6 +82363,7 @@ - "3.1.3.-" - "3.1.3.36" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -79905,6 +82387,7 @@ - "3.1.3.-" - "3.1.3.36" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -79928,6 +82411,7 @@ - "3.1.3.-" - "3.1.3.36" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -79951,6 +82435,7 @@ - "3.1.3.-" - "3.1.3.36" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -79974,6 +82459,7 @@ - "3.1.3.-" - "3.1.3.36" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -79997,6 +82483,7 @@ - "3.1.3.-" - "3.1.3.36" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -80018,6 +82505,7 @@ - gene_reaction_rule: "YKL212W" - eccodes: "3.1.3.-" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -80039,6 +82527,7 @@ - gene_reaction_rule: "YKL212W" - eccodes: "3.1.3.-" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -80060,6 +82549,7 @@ - gene_reaction_rule: "YKL212W" - eccodes: "3.1.3.-" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -80081,6 +82571,7 @@ - gene_reaction_rule: "YKL212W" - eccodes: "3.1.3.-" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -80102,6 +82593,7 @@ - gene_reaction_rule: "YKL212W" - eccodes: "3.1.3.-" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -80123,6 +82615,7 @@ - gene_reaction_rule: "YKL212W" - eccodes: "3.1.3.-" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -80144,6 +82637,7 @@ - gene_reaction_rule: "YKL212W" - eccodes: "3.1.3.-" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -80165,6 +82659,7 @@ - gene_reaction_rule: "YKL212W" - eccodes: "3.1.3.-" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -80186,6 +82681,7 @@ - gene_reaction_rule: "YKL212W" - eccodes: "3.1.3.-" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -80207,6 +82703,7 @@ - gene_reaction_rule: "YKL212W" - eccodes: "3.1.3.-" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -80228,6 +82725,7 @@ - gene_reaction_rule: "YKL212W" - eccodes: "3.1.3.-" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -80249,6 +82747,7 @@ - gene_reaction_rule: "YKL212W" - eccodes: "3.1.3.-" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -80270,6 +82769,7 @@ - gene_reaction_rule: "YKL212W" - eccodes: "3.1.3.-" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -80291,6 +82791,7 @@ - gene_reaction_rule: "YKL212W" - eccodes: "3.1.3.-" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -80312,6 +82813,7 @@ - gene_reaction_rule: "YKL212W" - eccodes: "3.1.3.-" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -80333,6 +82835,7 @@ - gene_reaction_rule: "YKL212W" - eccodes: "3.1.3.-" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -80356,6 +82859,7 @@ - "3.1.3.-" - "3.1.3.36" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -80379,6 +82883,7 @@ - "3.1.3.-" - "3.1.3.36" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -80402,6 +82907,7 @@ - "3.1.3.-" - "3.1.3.36" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -80425,6 +82931,7 @@ - "3.1.3.-" - "3.1.3.36" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -80448,6 +82955,7 @@ - "3.1.3.-" - "3.1.3.36" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -80471,6 +82979,7 @@ - "3.1.3.-" - "3.1.3.36" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -80494,6 +83003,7 @@ - "3.1.3.-" - "3.1.3.36" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -80517,6 +83027,7 @@ - "3.1.3.-" - "3.1.3.36" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -80540,6 +83051,7 @@ - "3.1.3.-" - "3.1.3.36" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -80563,6 +83075,7 @@ - "3.1.3.-" - "3.1.3.36" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -80586,6 +83099,7 @@ - "3.1.3.-" - "3.1.3.36" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -80609,6 +83123,7 @@ - "3.1.3.-" - "3.1.3.36" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -80632,6 +83147,7 @@ - "3.1.3.-" - "3.1.3.36" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -80655,6 +83171,7 @@ - "3.1.3.-" - "3.1.3.36" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -80678,6 +83195,7 @@ - "3.1.3.-" - "3.1.3.36" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -80701,6 +83219,7 @@ - "3.1.3.-" - "3.1.3.36" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -80724,6 +83243,7 @@ - "3.1.3.-" - "3.1.3.36" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -80747,6 +83267,7 @@ - "3.1.3.-" - "3.1.3.36" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -80770,6 +83291,7 @@ - "3.1.3.-" - "3.1.3.36" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -80793,6 +83315,7 @@ - "3.1.3.-" - "3.1.3.36" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -80816,6 +83339,7 @@ - "3.1.3.-" - "3.1.3.36" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -80839,6 +83363,7 @@ - "3.1.3.-" - "3.1.3.36" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -80862,6 +83387,7 @@ - "3.1.3.-" - "3.1.3.36" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -80885,6 +83411,7 @@ - "3.1.3.-" - "3.1.3.36" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -80908,6 +83435,7 @@ - "3.1.3.-" - "3.1.3.36" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -80931,6 +83459,7 @@ - "3.1.3.-" - "3.1.3.36" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -80954,6 +83483,7 @@ - "3.1.3.-" - "3.1.3.36" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -80977,6 +83507,7 @@ - "3.1.3.-" - "3.1.3.36" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -81000,6 +83531,7 @@ - "3.1.3.-" - "3.1.3.36" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -81023,6 +83555,7 @@ - "3.1.3.-" - "3.1.3.36" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -81046,6 +83579,7 @@ - "3.1.3.-" - "3.1.3.36" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -81069,6 +83603,7 @@ - "3.1.3.-" - "3.1.3.36" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -81090,6 +83625,7 @@ - gene_reaction_rule: "YOL065C" - eccodes: "3.1.3.36" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -81111,6 +83647,7 @@ - gene_reaction_rule: "YOL065C" - eccodes: "3.1.3.36" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -81132,6 +83669,7 @@ - gene_reaction_rule: "YOL065C" - eccodes: "3.1.3.36" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -81153,6 +83691,7 @@ - gene_reaction_rule: "YOL065C" - eccodes: "3.1.3.36" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -81174,6 +83713,7 @@ - gene_reaction_rule: "YOL065C" - eccodes: "3.1.3.36" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -81195,6 +83735,7 @@ - gene_reaction_rule: "YOL065C" - eccodes: "3.1.3.36" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -81216,6 +83757,7 @@ - gene_reaction_rule: "YOL065C" - eccodes: "3.1.3.36" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -81237,6 +83779,7 @@ - gene_reaction_rule: "YOL065C" - eccodes: "3.1.3.36" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - kegg.pathway: - "sce00562" @@ -81255,9 +83798,10 @@ - s_3416: -1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "YLR386W and YNL325C" + - gene_reaction_rule: "YFR019W and YNL325C and YFR021W and YNL054W and YLR386W" - eccodes: "3.1.3.-" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - pubmed: "22345606" - sbo: "SBO:0000176" @@ -81273,9 +83817,10 @@ - s_3417: -1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "YLR386W and YNL325C" + - gene_reaction_rule: "YFR019W and YNL325C and YFR021W and YNL054W and YLR386W" - eccodes: "3.1.3.-" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - pubmed: "22345606" - sbo: "SBO:0000176" @@ -81291,9 +83836,10 @@ - s_3418: -1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "YLR386W and YNL325C" + - gene_reaction_rule: "YFR019W and YNL325C and YFR021W and YNL054W and YLR386W" - eccodes: "3.1.3.-" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - pubmed: "22345606" - sbo: "SBO:0000176" @@ -81309,9 +83855,10 @@ - s_3419: -1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "YLR386W and YNL325C" + - gene_reaction_rule: "YFR019W and YNL325C and YFR021W and YNL054W and YLR386W" - eccodes: "3.1.3.-" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - pubmed: "22345606" - sbo: "SBO:0000176" @@ -81327,9 +83874,10 @@ - s_3420: -1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "YLR386W and YNL325C" + - gene_reaction_rule: "YFR019W and YNL325C and YFR021W and YNL054W and YLR386W" - eccodes: "3.1.3.-" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - pubmed: "22345606" - sbo: "SBO:0000176" @@ -81345,9 +83893,10 @@ - s_3421: -1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "YLR386W and YNL325C" + - gene_reaction_rule: "YFR019W and YNL325C and YFR021W and YNL054W and YLR386W" - eccodes: "3.1.3.-" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - pubmed: "22345606" - sbo: "SBO:0000176" @@ -81363,9 +83912,10 @@ - s_3422: -1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "YLR386W and YNL325C" + - gene_reaction_rule: "YFR019W and YNL325C and YFR021W and YNL054W and YLR386W" - eccodes: "3.1.3.-" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - pubmed: "22345606" - sbo: "SBO:0000176" @@ -81381,9 +83931,10 @@ - s_3423: -1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "YLR386W and YNL325C" + - gene_reaction_rule: "YFR019W and YNL325C and YFR021W and YNL054W and YLR386W" - eccodes: "3.1.3.-" - subsystem: + - "Inositol phosphate metabolism" - annotation: !!omap - pubmed: "22345606" - sbo: "SBO:0000176" @@ -81404,6 +83955,7 @@ - "3.1.3.4" - "3.1.3.81" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00561" @@ -81428,6 +83980,7 @@ - "3.1.3.4" - "3.1.3.81" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00561" @@ -81452,6 +84005,7 @@ - "3.1.3.4" - "3.1.3.81" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00561" @@ -81476,6 +84030,7 @@ - "3.1.3.4" - "3.1.3.81" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00561" @@ -81500,6 +84055,7 @@ - "3.1.3.4" - "3.1.3.81" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00561" @@ -81524,6 +84080,7 @@ - "3.1.3.4" - "3.1.3.81" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00561" @@ -81548,6 +84105,7 @@ - "3.1.3.4" - "3.1.3.81" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00561" @@ -81572,6 +84130,7 @@ - "3.1.3.4" - "3.1.3.81" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00561" @@ -81596,6 +84155,7 @@ - "3.1.3.-" - "3.1.3.4" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - pubmed: "22345606" - sbo: "SBO:0000176" @@ -81616,6 +84176,7 @@ - "3.1.3.-" - "3.1.3.4" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - pubmed: "22345606" - sbo: "SBO:0000176" @@ -81636,6 +84197,7 @@ - "3.1.3.-" - "3.1.3.4" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - pubmed: "22345606" - sbo: "SBO:0000176" @@ -81656,6 +84218,7 @@ - "3.1.3.-" - "3.1.3.4" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - pubmed: "22345606" - sbo: "SBO:0000176" @@ -81676,6 +84239,7 @@ - "3.1.3.-" - "3.1.3.4" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - pubmed: "22345606" - sbo: "SBO:0000176" @@ -81696,6 +84260,7 @@ - "3.1.3.-" - "3.1.3.4" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - pubmed: "22345606" - sbo: "SBO:0000176" @@ -81716,6 +84281,7 @@ - "3.1.3.-" - "3.1.3.4" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - pubmed: "22345606" - sbo: "SBO:0000176" @@ -81736,6 +84302,7 @@ - "3.1.3.-" - "3.1.3.4" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - pubmed: "22345606" - sbo: "SBO:0000176" @@ -81753,6 +84320,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YER037W" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - pubmed: "22345606" - sbo: "SBO:0000176" @@ -81770,6 +84338,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YER037W" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - pubmed: "22345606" - sbo: "SBO:0000176" @@ -81787,6 +84356,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YER037W" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - pubmed: "22345606" - sbo: "SBO:0000176" @@ -81804,6 +84374,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YER037W" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - pubmed: "22345606" - sbo: "SBO:0000176" @@ -81824,6 +84395,7 @@ - "3.1.3.4" - "3.1.3.81" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00561" @@ -81848,6 +84420,7 @@ - "3.1.3.4" - "3.1.3.81" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00561" @@ -81872,6 +84445,7 @@ - "3.1.3.4" - "3.1.3.81" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00561" @@ -81896,6 +84470,7 @@ - "3.1.3.4" - "3.1.3.81" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00561" @@ -81920,6 +84495,7 @@ - "3.1.3.-" - "3.1.3.4" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - pubmed: "22345606" - sbo: "SBO:0000176" @@ -81940,6 +84516,7 @@ - "3.1.3.-" - "3.1.3.4" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - pubmed: "22345606" - sbo: "SBO:0000176" @@ -81960,6 +84537,7 @@ - "3.1.3.-" - "3.1.3.4" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - pubmed: "22345606" - sbo: "SBO:0000176" @@ -81980,6 +84558,7 @@ - "3.1.3.-" - "3.1.3.4" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - pubmed: "22345606" - sbo: "SBO:0000176" @@ -81998,6 +84577,7 @@ - gene_reaction_rule: "YKL140W or YLL012W" - eccodes: "3.1.1.13" - subsystem: + - "Steroid biosynthesis" - annotation: !!omap - kegg.pathway: "sce00100" - pubmed: @@ -82019,6 +84599,7 @@ - gene_reaction_rule: "YKL140W or YLL012W" - eccodes: "3.1.1.13" - subsystem: + - "Steroid biosynthesis" - annotation: !!omap - kegg.pathway: "sce00100" - metanetx.reaction: "MNXR119162" @@ -82041,6 +84622,7 @@ - gene_reaction_rule: "YLL012W" - eccodes: "3.1.1.13" - subsystem: + - "Steroid biosynthesis" - annotation: !!omap - pubmed: "16835446" - sbo: "SBO:0000176" @@ -82059,6 +84641,7 @@ - gene_reaction_rule: "YLL012W" - eccodes: "3.1.1.13" - subsystem: + - "Steroid biosynthesis" - annotation: !!omap - pubmed: "16835446" - sbo: "SBO:0000176" @@ -82077,6 +84660,7 @@ - gene_reaction_rule: "YLL012W" - eccodes: "3.1.1.13" - subsystem: + - "Steroid biosynthesis" - annotation: !!omap - pubmed: "16835446" - sbo: "SBO:0000176" @@ -82095,6 +84679,7 @@ - gene_reaction_rule: "YLL012W" - eccodes: "3.1.1.13" - subsystem: + - "Steroid biosynthesis" - annotation: !!omap - pubmed: "16835446" - sbo: "SBO:0000176" @@ -82113,6 +84698,7 @@ - gene_reaction_rule: "YLL012W" - eccodes: "3.1.1.13" - subsystem: + - "Steroid biosynthesis" - annotation: !!omap - pubmed: "16835446" - sbo: "SBO:0000176" @@ -82131,6 +84717,7 @@ - gene_reaction_rule: "YLL012W" - eccodes: "3.1.1.13" - subsystem: + - "Steroid biosynthesis" - annotation: !!omap - metanetx.reaction: "MNXR119160" - pubmed: "16835446" @@ -82150,6 +84737,7 @@ - gene_reaction_rule: "YLL012W" - eccodes: "3.1.1.13" - subsystem: + - "Steroid biosynthesis" - annotation: !!omap - pubmed: "16835446" - sbo: "SBO:0000176" @@ -82168,6 +84756,7 @@ - gene_reaction_rule: "YLL012W" - eccodes: "3.1.1.13" - subsystem: + - "Steroid biosynthesis" - annotation: !!omap - pubmed: "16835446" - sbo: "SBO:0000176" @@ -82186,6 +84775,7 @@ - gene_reaction_rule: "YLR020C" - eccodes: "3.1.1.13" - subsystem: + - "Steroid biosynthesis" - annotation: !!omap - pubmed: "15632184" - sbo: "SBO:0000176" @@ -82204,6 +84794,7 @@ - gene_reaction_rule: "YLR020C" - eccodes: "3.1.1.13" - subsystem: + - "Steroid biosynthesis" - annotation: !!omap - pubmed: "15632184" - sbo: "SBO:0000176" @@ -82224,6 +84815,7 @@ - "3.1.1.-" - "3.1.1.3" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00100" @@ -82249,6 +84841,7 @@ - "3.1.1.-" - "3.1.1.3" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00100" @@ -82274,6 +84867,7 @@ - "3.1.1.-" - "3.1.1.3" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00100" @@ -82299,6 +84893,7 @@ - "3.1.1.-" - "3.1.1.3" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00100" @@ -82324,6 +84919,7 @@ - "3.1.1.-" - "3.1.1.3" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00100" @@ -82349,6 +84945,7 @@ - "3.1.1.-" - "3.1.1.3" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00100" @@ -82374,6 +84971,7 @@ - "3.1.1.-" - "3.1.1.3" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00100" @@ -82399,6 +84997,7 @@ - "3.1.1.-" - "3.1.1.3" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00100" @@ -82424,6 +85023,7 @@ - "3.1.1.-" - "3.1.1.3" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00100" @@ -82449,6 +85049,7 @@ - "3.1.1.-" - "3.1.1.3" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00100" @@ -82474,6 +85075,7 @@ - "3.1.1.-" - "3.1.1.3" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00100" @@ -82499,6 +85101,7 @@ - "3.1.1.-" - "3.1.1.3" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00100" @@ -82524,6 +85127,7 @@ - "3.1.1.-" - "3.1.1.3" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00100" @@ -82549,6 +85153,7 @@ - "3.1.1.-" - "3.1.1.3" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00100" @@ -82574,6 +85179,7 @@ - "3.1.1.-" - "3.1.1.3" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00100" @@ -82599,6 +85205,7 @@ - "3.1.1.-" - "3.1.1.3" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00100" @@ -82624,6 +85231,7 @@ - "3.1.1.-" - "3.1.1.3" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00100" @@ -82649,6 +85257,7 @@ - "3.1.1.-" - "3.1.1.3" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00100" @@ -82674,6 +85283,7 @@ - "3.1.1.-" - "3.1.1.3" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00100" @@ -82699,6 +85309,7 @@ - "3.1.1.-" - "3.1.1.3" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00100" @@ -82724,6 +85335,7 @@ - "3.1.1.-" - "3.1.1.3" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00100" @@ -82749,6 +85361,7 @@ - "3.1.1.-" - "3.1.1.3" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00100" @@ -82774,6 +85387,7 @@ - "3.1.1.-" - "3.1.1.3" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00100" @@ -82799,6 +85413,7 @@ - "3.1.1.-" - "3.1.1.3" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00100" @@ -82824,6 +85439,7 @@ - "3.1.1.-" - "3.1.1.3" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00100" @@ -82849,6 +85465,7 @@ - "3.1.1.-" - "3.1.1.3" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00100" @@ -82874,6 +85491,7 @@ - "3.1.1.-" - "3.1.1.3" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00100" @@ -82899,6 +85517,7 @@ - "3.1.1.-" - "3.1.1.3" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00100" @@ -82924,6 +85543,7 @@ - "3.1.1.-" - "3.1.1.3" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00100" @@ -82949,6 +85569,7 @@ - "3.1.1.-" - "3.1.1.3" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00100" @@ -82974,6 +85595,7 @@ - "3.1.1.-" - "3.1.1.3" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00100" @@ -82999,6 +85621,7 @@ - "3.1.1.-" - "3.1.1.3" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00100" @@ -83022,6 +85645,7 @@ - gene_reaction_rule: "YMR313C" - eccodes: "3.1.1.3" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -83041,6 +85665,7 @@ - gene_reaction_rule: "YCR068W or YMR313C" - eccodes: "3.1.1.3" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -83060,6 +85685,7 @@ - gene_reaction_rule: "YMR313C" - eccodes: "3.1.1.3" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -83079,6 +85705,7 @@ - gene_reaction_rule: "YMR313C" - eccodes: "3.1.1.3" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -83098,6 +85725,7 @@ - gene_reaction_rule: "YMR313C" - eccodes: "3.1.1.3" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -83117,6 +85745,7 @@ - gene_reaction_rule: "YMR313C" - eccodes: "3.1.1.3" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -83136,6 +85765,7 @@ - gene_reaction_rule: "YMR313C" - eccodes: "3.1.1.3" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -83155,6 +85785,7 @@ - gene_reaction_rule: "YMR313C" - eccodes: "3.1.1.3" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -83174,6 +85805,7 @@ - gene_reaction_rule: "YDR058C" - eccodes: "3.1.1.3" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -83193,6 +85825,7 @@ - gene_reaction_rule: "YDR058C" - eccodes: "3.1.1.3" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -83212,6 +85845,7 @@ - gene_reaction_rule: "YDR058C" - eccodes: "3.1.1.3" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -83231,6 +85865,7 @@ - gene_reaction_rule: "YDR058C" - eccodes: "3.1.1.3" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -83250,6 +85885,7 @@ - gene_reaction_rule: "YKL094W" - eccodes: "3.1.1.23" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -83269,6 +85905,7 @@ - gene_reaction_rule: "YKL094W" - eccodes: "3.1.1.23" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -83288,6 +85925,7 @@ - gene_reaction_rule: "YKL094W" - eccodes: "3.1.1.23" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -83307,6 +85945,7 @@ - gene_reaction_rule: "YKL094W" - eccodes: "3.1.1.23" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "22345606" @@ -83325,6 +85964,7 @@ - gene_reaction_rule: "YMR313C" - eccodes: "3.1.1.3" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "20016004" @@ -83343,6 +85983,7 @@ - gene_reaction_rule: "YMR313C" - eccodes: "3.1.1.3" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "20016004" @@ -83361,6 +86002,7 @@ - gene_reaction_rule: "YMR313C" - eccodes: "3.1.1.3" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "20016004" @@ -83379,6 +86021,7 @@ - gene_reaction_rule: "YMR313C" - eccodes: "3.1.1.3" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: "sce00561" - pubmed: "20016004" @@ -83398,6 +86041,7 @@ - gene_reaction_rule: "YKR089C" - eccodes: "3.1.1.3" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00100" @@ -83421,6 +86065,7 @@ - gene_reaction_rule: "YKR089C" - eccodes: "3.1.1.3" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00100" @@ -83444,6 +86089,7 @@ - gene_reaction_rule: "YKR089C" - eccodes: "3.1.1.3" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00100" @@ -83467,6 +86113,7 @@ - gene_reaction_rule: "YKR089C" - eccodes: "3.1.1.3" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00100" @@ -83490,6 +86137,7 @@ - gene_reaction_rule: "YKR089C" - eccodes: "3.1.1.3" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00100" @@ -83513,6 +86161,7 @@ - gene_reaction_rule: "YKR089C" - eccodes: "3.1.1.3" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00100" @@ -83536,6 +86185,7 @@ - gene_reaction_rule: "YKR089C" - eccodes: "3.1.1.3" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00100" @@ -83559,6 +86209,7 @@ - gene_reaction_rule: "YKR089C" - eccodes: "3.1.1.3" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00100" @@ -83582,6 +86233,7 @@ - gene_reaction_rule: "YKR089C" - eccodes: "3.1.1.3" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00100" @@ -83605,6 +86257,7 @@ - gene_reaction_rule: "YKR089C" - eccodes: "3.1.1.3" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00100" @@ -83628,6 +86281,7 @@ - gene_reaction_rule: "YKR089C" - eccodes: "3.1.1.3" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00100" @@ -83651,6 +86305,7 @@ - gene_reaction_rule: "YKR089C" - eccodes: "3.1.1.3" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00100" @@ -83674,6 +86329,7 @@ - gene_reaction_rule: "YKR089C" - eccodes: "3.1.1.3" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00100" @@ -83697,6 +86353,7 @@ - gene_reaction_rule: "YKR089C" - eccodes: "3.1.1.3" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00100" @@ -83720,6 +86377,7 @@ - gene_reaction_rule: "YKR089C" - eccodes: "3.1.1.3" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00100" @@ -83743,6 +86401,7 @@ - gene_reaction_rule: "YKR089C" - eccodes: "3.1.1.3" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.pathway: - "sce00100" @@ -83764,6 +86423,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - sbo: "SBO:0000176" - confidence_score: 0 @@ -83779,6 +86439,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - sbo: "SBO:0000176" - confidence_score: 0 @@ -83794,6 +86455,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - sbo: "SBO:0000176" - confidence_score: 0 @@ -83809,6 +86471,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - sbo: "SBO:0000176" - confidence_score: 0 @@ -83824,6 +86487,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - sbo: "SBO:0000176" - confidence_score: 0 @@ -83839,6 +86503,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - sbo: "SBO:0000176" - confidence_score: 0 @@ -83854,6 +86519,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - sbo: "SBO:0000176" - confidence_score: 0 @@ -83869,6 +86535,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - sbo: "SBO:0000176" - confidence_score: 0 @@ -83884,6 +86551,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - sbo: "SBO:0000176" - confidence_score: 0 @@ -83899,6 +86567,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - sbo: "SBO:0000176" - confidence_score: 0 @@ -83914,6 +86583,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - sbo: "SBO:0000176" - confidence_score: 0 @@ -83929,6 +86599,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - sbo: "SBO:0000176" - confidence_score: 0 @@ -83944,6 +86615,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - sbo: "SBO:0000176" - confidence_score: 0 @@ -83959,6 +86631,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - sbo: "SBO:0000176" - confidence_score: 0 @@ -83974,6 +86647,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - sbo: "SBO:0000176" - confidence_score: 0 @@ -83989,6 +86663,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - sbo: "SBO:0000176" - confidence_score: 0 @@ -84005,6 +86680,7 @@ - gene_reaction_rule: "YDR072C" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -84024,6 +86700,7 @@ - gene_reaction_rule: "YDR072C" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -84043,6 +86720,7 @@ - gene_reaction_rule: "YDR072C" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -84062,6 +86740,7 @@ - gene_reaction_rule: "YDR072C" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -84081,6 +86760,7 @@ - gene_reaction_rule: "YDR072C" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -84100,6 +86780,7 @@ - gene_reaction_rule: "YDR072C" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -84119,6 +86800,7 @@ - gene_reaction_rule: "YDR072C" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -84138,6 +86820,7 @@ - gene_reaction_rule: "YDR072C" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -84157,6 +86840,7 @@ - gene_reaction_rule: "YDR072C" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -84176,6 +86860,7 @@ - gene_reaction_rule: "YDR072C" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -84195,6 +86880,7 @@ - gene_reaction_rule: "YDR072C" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -84214,6 +86900,7 @@ - gene_reaction_rule: "YDR072C" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -84233,6 +86920,7 @@ - gene_reaction_rule: "YDR072C" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -84252,6 +86940,7 @@ - gene_reaction_rule: "YDR072C" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -84271,6 +86960,7 @@ - gene_reaction_rule: "YDR072C" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -84290,6 +86980,7 @@ - gene_reaction_rule: "YDR072C" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -84309,6 +87000,7 @@ - gene_reaction_rule: "YDR072C" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -84328,6 +87020,7 @@ - gene_reaction_rule: "YDR072C" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -84347,6 +87040,7 @@ - gene_reaction_rule: "YDR072C" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -84366,6 +87060,7 @@ - gene_reaction_rule: "YDR072C" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -84385,6 +87080,7 @@ - gene_reaction_rule: "YDR072C" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -84404,6 +87100,7 @@ - gene_reaction_rule: "YDR072C" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -84423,6 +87120,7 @@ - gene_reaction_rule: "YDR072C" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -84442,6 +87140,7 @@ - gene_reaction_rule: "YDR072C" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -84461,6 +87160,7 @@ - gene_reaction_rule: "YDR072C" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -84480,6 +87180,7 @@ - gene_reaction_rule: "YDR072C" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -84499,6 +87200,7 @@ - gene_reaction_rule: "YDR072C" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -84518,6 +87220,7 @@ - gene_reaction_rule: "YDR072C" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -84537,6 +87240,7 @@ - gene_reaction_rule: "YDR072C" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -84556,6 +87260,7 @@ - gene_reaction_rule: "YDR072C" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -84575,6 +87280,7 @@ - gene_reaction_rule: "YDR072C" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -84594,6 +87300,7 @@ - gene_reaction_rule: "YDR072C" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -84613,6 +87320,7 @@ - gene_reaction_rule: "YDR072C" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -84632,6 +87340,7 @@ - gene_reaction_rule: "YDR072C" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -84651,6 +87360,7 @@ - gene_reaction_rule: "YDR072C" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -84670,6 +87380,7 @@ - gene_reaction_rule: "YDR072C" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -84689,6 +87400,7 @@ - gene_reaction_rule: "YDR072C" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -84708,6 +87420,7 @@ - gene_reaction_rule: "YDR072C" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -84727,6 +87440,7 @@ - gene_reaction_rule: "YDR072C" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -84746,6 +87460,7 @@ - gene_reaction_rule: "YDR072C" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -84765,6 +87480,7 @@ - gene_reaction_rule: "YDR072C" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -84784,6 +87500,7 @@ - gene_reaction_rule: "YDR072C" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -84803,6 +87520,7 @@ - gene_reaction_rule: "YDR072C" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -84822,6 +87540,7 @@ - gene_reaction_rule: "YDR072C" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -84841,6 +87560,7 @@ - gene_reaction_rule: "YDR072C" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -84860,6 +87580,7 @@ - gene_reaction_rule: "YDR072C" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -84879,6 +87600,7 @@ - gene_reaction_rule: "YDR072C" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -84898,6 +87620,7 @@ - gene_reaction_rule: "YDR072C" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -84917,6 +87640,7 @@ - gene_reaction_rule: "YDR072C" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -84936,6 +87660,7 @@ - gene_reaction_rule: "YDR072C" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -84955,6 +87680,7 @@ - gene_reaction_rule: "YDR072C" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -84974,6 +87700,7 @@ - gene_reaction_rule: "YDR072C" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -84993,6 +87720,7 @@ - gene_reaction_rule: "YDR072C" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -85012,6 +87740,7 @@ - gene_reaction_rule: "YDR072C" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -85031,6 +87760,7 @@ - gene_reaction_rule: "YDR072C" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -85050,6 +87780,7 @@ - gene_reaction_rule: "YDR072C" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -85069,6 +87800,7 @@ - gene_reaction_rule: "YDR072C" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -85088,6 +87820,7 @@ - gene_reaction_rule: "YDR072C" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -85107,6 +87840,7 @@ - gene_reaction_rule: "YDR072C" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -85126,6 +87860,7 @@ - gene_reaction_rule: "YDR072C" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -85145,6 +87880,7 @@ - gene_reaction_rule: "YDR072C" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -85164,6 +87900,7 @@ - gene_reaction_rule: "YDR072C" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -85183,6 +87920,7 @@ - gene_reaction_rule: "YDR072C" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -85202,6 +87940,7 @@ - gene_reaction_rule: "YDR072C" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -85221,6 +87960,7 @@ - gene_reaction_rule: "YDR072C" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -85240,6 +87980,7 @@ - gene_reaction_rule: "YDR072C" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -85259,6 +88000,7 @@ - gene_reaction_rule: "YDR072C" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -85278,6 +88020,7 @@ - gene_reaction_rule: "YDR072C" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -85297,6 +88040,7 @@ - gene_reaction_rule: "YDR072C" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -85316,6 +88060,7 @@ - gene_reaction_rule: "YDR072C" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -85335,6 +88080,7 @@ - gene_reaction_rule: "YDR072C" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -85354,6 +88100,7 @@ - gene_reaction_rule: "YDR072C" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -85373,6 +88120,7 @@ - gene_reaction_rule: "YDR072C" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -85392,6 +88140,7 @@ - gene_reaction_rule: "YDR072C" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -85411,6 +88160,7 @@ - gene_reaction_rule: "YDR072C" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -85430,6 +88180,7 @@ - gene_reaction_rule: "YDR072C" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -85449,6 +88200,7 @@ - gene_reaction_rule: "YDR072C" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -85468,6 +88220,7 @@ - gene_reaction_rule: "YDR072C" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -85487,6 +88240,7 @@ - gene_reaction_rule: "YDR072C" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -85506,6 +88260,7 @@ - gene_reaction_rule: "YDR072C" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -85525,6 +88280,7 @@ - gene_reaction_rule: "YDR367W and YKL004W" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -85544,6 +88300,7 @@ - gene_reaction_rule: "YDR367W and YKL004W" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -85563,6 +88320,7 @@ - gene_reaction_rule: "YDR367W and YKL004W" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -85582,6 +88340,7 @@ - gene_reaction_rule: "YDR367W and YKL004W" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -85601,6 +88360,7 @@ - gene_reaction_rule: "YDR367W and YKL004W" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -85620,6 +88380,7 @@ - gene_reaction_rule: "YDR367W and YKL004W" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -85639,6 +88400,7 @@ - gene_reaction_rule: "YDR367W and YKL004W" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -85658,6 +88420,7 @@ - gene_reaction_rule: "YDR367W and YKL004W" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -85677,6 +88440,7 @@ - gene_reaction_rule: "YDR367W and YKL004W" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -85696,6 +88460,7 @@ - gene_reaction_rule: "YDR367W and YKL004W" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -85715,6 +88480,7 @@ - gene_reaction_rule: "YDR367W and YKL004W" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -85734,6 +88500,7 @@ - gene_reaction_rule: "YDR367W and YKL004W" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -85753,6 +88520,7 @@ - gene_reaction_rule: "YDR367W and YKL004W" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -85772,6 +88540,7 @@ - gene_reaction_rule: "YDR367W and YKL004W" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -85791,6 +88560,7 @@ - gene_reaction_rule: "YDR367W and YKL004W" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -85810,6 +88580,7 @@ - gene_reaction_rule: "YDR367W and YKL004W" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -85829,6 +88600,7 @@ - gene_reaction_rule: "YDR367W and YKL004W" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -85848,6 +88620,7 @@ - gene_reaction_rule: "YDR367W and YKL004W" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -85867,6 +88640,7 @@ - gene_reaction_rule: "YDR367W and YKL004W" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -85886,6 +88660,7 @@ - gene_reaction_rule: "YDR367W and YKL004W" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -85905,6 +88680,7 @@ - gene_reaction_rule: "YDR367W and YKL004W" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -85924,6 +88700,7 @@ - gene_reaction_rule: "YDR367W and YKL004W" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -85943,6 +88720,7 @@ - gene_reaction_rule: "YDR367W and YKL004W" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -85962,6 +88740,7 @@ - gene_reaction_rule: "YDR367W and YKL004W" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -85981,6 +88760,7 @@ - gene_reaction_rule: "YDR367W and YKL004W" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -86000,6 +88780,7 @@ - gene_reaction_rule: "YDR367W and YKL004W" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -86019,6 +88800,7 @@ - gene_reaction_rule: "YDR367W and YKL004W" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -86038,6 +88820,7 @@ - gene_reaction_rule: "YDR367W and YKL004W" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -86057,6 +88840,7 @@ - gene_reaction_rule: "YDR367W and YKL004W" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -86076,6 +88860,7 @@ - gene_reaction_rule: "YDR367W and YKL004W" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -86095,6 +88880,7 @@ - gene_reaction_rule: "YDR367W and YKL004W" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -86114,6 +88900,7 @@ - gene_reaction_rule: "YDR367W and YKL004W" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -86133,6 +88920,7 @@ - gene_reaction_rule: "YDR367W and YKL004W" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -86152,6 +88940,7 @@ - gene_reaction_rule: "YDR367W and YKL004W" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -86171,6 +88960,7 @@ - gene_reaction_rule: "YDR367W and YKL004W" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -86190,6 +88980,7 @@ - gene_reaction_rule: "YDR367W and YKL004W" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -86209,6 +89000,7 @@ - gene_reaction_rule: "YDR367W and YKL004W" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -86228,6 +89020,7 @@ - gene_reaction_rule: "YDR367W and YKL004W" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -86247,6 +89040,7 @@ - gene_reaction_rule: "YDR367W and YKL004W" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -86266,6 +89060,7 @@ - gene_reaction_rule: "YDR367W and YKL004W" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -86285,6 +89080,7 @@ - gene_reaction_rule: "YDR367W and YKL004W" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -86304,6 +89100,7 @@ - gene_reaction_rule: "YDR367W and YKL004W" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -86323,6 +89120,7 @@ - gene_reaction_rule: "YDR367W and YKL004W" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -86342,6 +89140,7 @@ - gene_reaction_rule: "YDR367W and YKL004W" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -86361,6 +89160,7 @@ - gene_reaction_rule: "YDR367W and YKL004W" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -86380,6 +89180,7 @@ - gene_reaction_rule: "YDR367W and YKL004W" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -86399,6 +89200,7 @@ - gene_reaction_rule: "YDR367W and YKL004W" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -86418,6 +89220,7 @@ - gene_reaction_rule: "YDR367W and YKL004W" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -86437,6 +89240,7 @@ - gene_reaction_rule: "YDR367W and YKL004W" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -86456,6 +89260,7 @@ - gene_reaction_rule: "YDR367W and YKL004W" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -86475,6 +89280,7 @@ - gene_reaction_rule: "YDR367W and YKL004W" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -86494,6 +89300,7 @@ - gene_reaction_rule: "YDR367W and YKL004W" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -86513,6 +89320,7 @@ - gene_reaction_rule: "YDR367W and YKL004W" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -86532,6 +89340,7 @@ - gene_reaction_rule: "YDR367W and YKL004W" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -86551,6 +89360,7 @@ - gene_reaction_rule: "YDR367W and YKL004W" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -86570,6 +89380,7 @@ - gene_reaction_rule: "YDR367W and YKL004W" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -86589,6 +89400,7 @@ - gene_reaction_rule: "YDR367W and YKL004W" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -86608,6 +89420,7 @@ - gene_reaction_rule: "YDR367W and YKL004W" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -86627,6 +89440,7 @@ - gene_reaction_rule: "YDR367W and YKL004W" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -86646,6 +89460,7 @@ - gene_reaction_rule: "YDR367W and YKL004W" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -86665,6 +89480,7 @@ - gene_reaction_rule: "YDR367W and YKL004W" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -86684,6 +89500,7 @@ - gene_reaction_rule: "YDR367W and YKL004W" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -86703,6 +89520,7 @@ - gene_reaction_rule: "YDR367W and YKL004W" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -86722,6 +89540,7 @@ - gene_reaction_rule: "YDR367W and YKL004W" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -86741,6 +89560,7 @@ - gene_reaction_rule: "YDR367W and YKL004W" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -86760,6 +89580,7 @@ - gene_reaction_rule: "YDR367W and YKL004W" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -86779,6 +89600,7 @@ - gene_reaction_rule: "YDR367W and YKL004W" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -86798,6 +89620,7 @@ - gene_reaction_rule: "YDR367W and YKL004W" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -86817,6 +89640,7 @@ - gene_reaction_rule: "YDR367W and YKL004W" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -86836,6 +89660,7 @@ - gene_reaction_rule: "YDR367W and YKL004W" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -86855,6 +89680,7 @@ - gene_reaction_rule: "YDR367W and YKL004W" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -86874,6 +89700,7 @@ - gene_reaction_rule: "YDR367W and YKL004W" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -86893,6 +89720,7 @@ - gene_reaction_rule: "YDR367W and YKL004W" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -86912,6 +89740,7 @@ - gene_reaction_rule: "YDR367W and YKL004W" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -86931,6 +89760,7 @@ - gene_reaction_rule: "YDR367W and YKL004W" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -86950,6 +89780,7 @@ - gene_reaction_rule: "YDR367W and YKL004W" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -86969,6 +89800,7 @@ - gene_reaction_rule: "YDR367W and YKL004W" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -86988,6 +89820,7 @@ - gene_reaction_rule: "YDR367W and YKL004W" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -87007,6 +89840,7 @@ - gene_reaction_rule: "YDR367W and YKL004W" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -87026,6 +89860,7 @@ - gene_reaction_rule: "YDR367W and YKL004W" - eccodes: "2.-.-.-" - subsystem: + - "Sphingoglycolipid metabolism" - annotation: !!omap - pubmed: - "18296751" @@ -87041,6 +89876,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, erm]" - annotation: !!omap - metanetx.reaction: "MNXR135773" - sbo: "SBO:0000655" @@ -87054,6 +89890,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, erm]" - annotation: !!omap - metanetx.reaction: "MNXR128297" - sbo: "SBO:0000655" @@ -87067,6 +89904,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, erm]" - annotation: !!omap - metanetx.reaction: "MNXR99101" - sbo: "SBO:0000655" @@ -87080,6 +89918,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, erm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -87092,6 +89931,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, erm]" - annotation: !!omap - metanetx.reaction: "MNXR99109" - sbo: "SBO:0000655" @@ -87105,6 +89945,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, erm]" - annotation: !!omap - metanetx.reaction: "MNXR99110" - sbo: "SBO:0000655" @@ -87118,6 +89959,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, erm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -87130,6 +89972,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, erm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -87142,6 +89985,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, erm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -87154,6 +89998,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, erm]" - annotation: !!omap - metanetx.reaction: "MNXR103046" - sbo: "SBO:0000655" @@ -87167,6 +90012,7 @@ - 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"Transport [c, erm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -87693,6 +90579,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, erm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -87705,6 +90592,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, erm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -87717,6 +90605,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, erm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -87729,6 +90618,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, erm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -87741,6 +90631,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, erm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -87753,6 +90644,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, erm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -87765,6 +90657,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, erm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -87777,6 +90670,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, erm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -87789,6 +90683,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, erm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -87801,6 +90696,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, erm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -87813,6 +90709,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, erm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -87825,6 +90722,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - 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sbo: "SBO:0000655" @@ -88055,6 +90970,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, lp]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -88067,6 +90983,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, lp]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -88079,6 +90996,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, lp]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -88091,6 +91009,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, lp]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -88103,6 +91022,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, lp]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -88115,6 +91035,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, lp]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -88127,6 +91048,7 @@ - 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"Transport [c, ce]" - annotation: !!omap - metanetx.reaction: "MNXR102871" - sbo: "SBO:0000655" @@ -88283,6 +91216,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YCR098C" - subsystem: + - "Transport [c, ce]" - annotation: !!omap - metanetx.reaction: "MNXR99874" - sbo: "SBO:0000655" @@ -88297,6 +91231,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YCR098C" - subsystem: + - "Transport [c, ce]" - annotation: !!omap - metanetx.reaction: "MNXR99888" - sbo: "SBO:0000655" @@ -88310,6 +91245,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, ce]" - annotation: !!omap - metanetx.reaction: "MNXR99101" - sbo: "SBO:0000655" @@ -88323,6 +91259,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, ce]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -88335,6 +91272,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, ce]" - annotation: !!omap - metanetx.reaction: "MNXR99109" - sbo: "SBO:0000655" @@ -88348,6 +91286,7 @@ - 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lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, ce]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -88435,6 +91380,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, ce]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -88447,6 +91393,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, ce]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -88459,6 +91406,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, ce]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -88471,6 +91419,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, ce]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -88483,6 +91432,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, ce]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -88495,6 +91445,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, ce]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -88507,6 +91458,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, ce]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -88519,6 +91471,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, ce]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -88531,6 +91484,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, ce]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -88543,6 +91497,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, ce]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -88555,6 +91510,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, ce]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -88567,6 +91523,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, ce]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -88579,6 +91536,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, ce]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -88591,6 +91549,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, ce]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -88603,6 +91562,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, n]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -88615,6 +91575,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, n]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -88627,6 +91588,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, n]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -88639,6 +91601,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, n]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -88651,6 +91614,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, n]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -88663,6 +91627,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, n]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -88675,6 +91640,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, n]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -88687,6 +91653,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, n]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -88699,6 +91666,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, n]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -88711,6 +91679,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, n]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -88723,6 +91692,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, n]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -88735,6 +91705,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, n]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -88747,6 +91718,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, n]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -88759,6 +91731,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, n]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -88771,6 +91744,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, n]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -88783,6 +91757,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, n]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -88795,6 +91770,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, vm]" - annotation: !!omap - metanetx.reaction: "MNXR98641" - sbo: "SBO:0000655" @@ -88809,6 +91785,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YNR013C" - subsystem: + - "Transport [c, vm]" - annotation: !!omap - metanetx.reaction: "MNXR102871" - sbo: "SBO:0000655" @@ -88822,6 +91799,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, vm]" - annotation: !!omap - metanetx.reaction: "MNXR100765" - sbo: "SBO:0000655" @@ -88835,6 +91813,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, vm]" - annotation: !!omap - metanetx.reaction: "MNXR96140" - sbo: "SBO:0000655" @@ -88848,6 +91827,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, vm]" - annotation: !!omap - metanetx.reaction: "MNXR95484" - sbo: "SBO:0000655" @@ -88861,6 +91841,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, vm]" - annotation: !!omap - metanetx.reaction: "MNXR96810" - sbo: "SBO:0000655" @@ -88874,6 +91855,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, vm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -88886,6 +91868,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, vm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -88898,6 +91881,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, vm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -88910,6 +91894,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, vm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -88922,6 +91907,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, vm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -88934,6 +91920,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, vm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -88946,6 +91933,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, vm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -88958,6 +91946,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, vm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -88970,6 +91959,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, gm]" - annotation: !!omap - metanetx.reaction: "MNXR98641" - sbo: "SBO:0000655" @@ -88983,6 +91973,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, gm]" - annotation: !!omap - metanetx.reaction: "MNXR102871" - sbo: "SBO:0000655" @@ -88996,6 +91987,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, gm]" - annotation: !!omap - metanetx.reaction: "MNXR100765" - sbo: "SBO:0000655" @@ -89009,6 +92001,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, gm]" - annotation: !!omap - metanetx.reaction: "MNXR96810" - sbo: "SBO:0000655" @@ -89022,6 +92015,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, gm]" - annotation: !!omap - metanetx.reaction: "MNXR96140" - sbo: "SBO:0000655" @@ -89035,6 +92029,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, gm]" - annotation: !!omap - metanetx.reaction: "MNXR95484" - sbo: "SBO:0000655" @@ -89048,6 +92043,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, mm]" - annotation: !!omap - metanetx.reaction: "MNXR98641" - sbo: "SBO:0000655" @@ -89061,6 +92057,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, mm]" - annotation: !!omap - metanetx.reaction: "MNXR96810" - sbo: "SBO:0000655" @@ -89074,6 +92071,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, mm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -89086,6 +92084,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, mm]" - annotation: !!omap - metanetx.reaction: "MNXR128426" - sbo: "SBO:0000655" @@ -89099,6 +92098,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, mm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -89111,6 +92111,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, mm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -89123,6 +92124,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, mm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -89135,6 +92137,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, mm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -89147,6 +92150,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, mm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -89159,6 +92163,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, mm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -89171,6 +92176,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, mm]" - annotation: !!omap - metanetx.reaction: "MNXR99101" - sbo: "SBO:0000655" @@ -89184,6 +92190,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, mm]" - annotation: !!omap - metanetx.reaction: "MNXR99109" - sbo: "SBO:0000655" @@ -89198,6 +92205,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YHR002W" - subsystem: + - "Transport [c, mm]" - annotation: !!omap - metanetx.reaction: "MNXR96815" - sbo: "SBO:0000655" @@ -89211,6 +92219,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, lp]" - annotation: !!omap - metanetx.reaction: "MNXR135773" - sbo: "SBO:0000655" @@ -89224,6 +92233,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, lp]" - annotation: !!omap - metanetx.reaction: "MNXR128297" - sbo: "SBO:0000655" @@ -89237,6 +92247,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, lp]" - annotation: !!omap - metanetx.reaction: "MNXR128298" - sbo: "SBO:0000655" @@ -89250,6 +92261,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, lp]" - annotation: !!omap - metanetx.reaction: "MNXR136128" - sbo: "SBO:0000655" @@ -89263,6 +92275,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, lp]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -89275,6 +92288,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, lp]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -89287,6 +92301,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, lp]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -89299,6 +92314,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, lp]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -89311,6 +92327,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, lp]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -89323,6 +92340,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, lp]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -89335,6 +92353,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, lp]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -89347,6 +92366,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, lp]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -89359,6 +92379,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, lp]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -89371,6 +92392,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, lp]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -89383,6 +92405,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, lp]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -89395,6 +92418,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, lp]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -89407,6 +92431,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, lp]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -89419,6 +92444,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, lp]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -89431,6 +92457,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, lp]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -89443,6 +92470,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, lp]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -89455,6 +92483,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, lp]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -89467,6 +92496,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, lp]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -89479,6 +92509,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, lp]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -89491,6 +92522,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, lp]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -89503,6 +92535,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, lp]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -89515,6 +92548,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, lp]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -89527,6 +92561,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, lp]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -89539,6 +92574,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, lp]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -89551,6 +92587,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, lp]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -89563,6 +92600,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, lp]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -89575,6 +92613,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, lp]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -89587,6 +92626,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, lp]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -89599,6 +92639,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, lp]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -89611,6 +92652,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, lp]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -89623,6 +92665,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, lp]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -89635,6 +92678,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, lp]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -89647,6 +92691,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, lp]" - annotation: !!omap - metanetx.reaction: "MNXR97944" - sbo: "SBO:0000655" @@ -89660,6 +92705,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, lp]" - annotation: !!omap - metanetx.reaction: "MNXR99529" - sbo: "SBO:0000655" @@ -89673,6 +92719,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, lp]" - annotation: !!omap - metanetx.reaction: "MNXR101014" - sbo: "SBO:0000655" @@ -89686,6 +92733,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, lp]" - annotation: !!omap - metanetx.reaction: "MNXR105285" - sbo: "SBO:0000655" @@ -89699,6 +92747,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, lp]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -89711,6 +92760,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, lp]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -89723,6 +92773,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, lp]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -89735,6 +92786,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, lp]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -89747,6 +92799,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, lp]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -89759,6 +92812,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, lp]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -89771,6 +92825,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, lp]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -89783,6 +92838,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, lp]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -89795,6 +92851,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, lp]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -89807,6 +92864,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, lp]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -89819,6 +92877,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, lp]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -89831,6 +92890,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, lp]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -89843,6 +92903,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, lp]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -89855,6 +92916,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, lp]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -89867,6 +92929,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, lp]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -89879,6 +92942,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, lp]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -89891,6 +92955,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, lp]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -89903,6 +92968,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, lp]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -89915,6 +92981,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, lp]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -89927,6 +92994,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, lp]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -89939,6 +93007,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, lp]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -89951,6 +93020,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, lp]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -89963,6 +93033,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, lp]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -89975,6 +93046,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, lp]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -89987,6 +93059,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, lp]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -89999,6 +93072,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, lp]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -90011,6 +93085,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, lp]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -90023,6 +93098,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, lp]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -90035,6 +93111,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, lp]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -90047,6 +93124,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, lp]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -90059,6 +93137,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, lp]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -90071,6 +93150,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, lp]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -90083,6 +93163,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, lp]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -90095,6 +93176,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, lp]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -90107,6 +93189,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, lp]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -90119,6 +93202,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, lp]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -90131,6 +93215,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, lp]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -90143,6 +93228,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, lp]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -90155,6 +93241,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, mm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -90167,6 +93254,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, mm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -90179,6 +93267,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, mm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -90191,6 +93280,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, mm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -90203,6 +93293,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, mm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -90215,6 +93306,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, mm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -90227,6 +93319,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, mm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -90239,6 +93332,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, mm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -90251,6 +93345,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, mm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -90263,6 +93358,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, mm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -90275,6 +93371,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, mm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -90287,6 +93384,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, mm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -90299,6 +93397,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, mm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -90311,6 +93410,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, mm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -90323,6 +93423,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, mm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -90335,6 +93436,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, mm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -90347,6 +93449,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, mm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -90359,6 +93462,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, mm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -90371,6 +93475,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, mm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -90383,6 +93488,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, mm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -90395,6 +93501,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, mm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -90407,6 +93514,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, mm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -90419,6 +93527,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, mm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -90431,6 +93540,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, mm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -90443,6 +93553,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, mm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -90455,6 +93566,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, mm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -90467,6 +93579,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, mm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -90479,6 +93592,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, mm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -90491,6 +93605,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, mm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -90503,6 +93618,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, mm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -90515,6 +93631,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, gm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -90527,6 +93644,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, gm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -90539,6 +93657,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, gm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -90551,6 +93670,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, gm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -90563,6 +93683,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, gm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -90575,6 +93696,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, gm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -90587,6 +93709,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, gm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -90599,6 +93722,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, gm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -90611,6 +93735,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, gm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -90623,6 +93748,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, gm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -90635,6 +93761,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, gm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -90647,6 +93774,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, gm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -90659,6 +93787,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, gm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -90671,6 +93800,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, gm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -90683,6 +93813,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, gm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -90695,6 +93826,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, gm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -90707,6 +93839,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, gm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -90719,6 +93852,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, gm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -90731,6 +93865,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, gm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -90743,6 +93878,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, gm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -90755,6 +93891,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, gm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -90767,6 +93904,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, gm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -90779,6 +93917,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, gm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -90791,6 +93930,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, gm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -90804,6 +93944,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YIL048W or YMR162C" - subsystem: + - "Transport [erm, gm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 2 @@ -90817,6 +93958,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YIL048W or YMR162C" - subsystem: + - "Transport [erm, gm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 2 @@ -90830,6 +93972,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YIL048W or YMR162C" - subsystem: + - "Transport [erm, gm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 2 @@ -90843,6 +93986,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YIL048W or YMR162C" - subsystem: + - "Transport [erm, gm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 2 @@ -90856,6 +94000,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YIL048W or YMR162C" - subsystem: + - "Transport [erm, gm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 2 @@ -90869,6 +94014,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YIL048W or YMR162C" - subsystem: + - "Transport [erm, gm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 2 @@ -90882,6 +94028,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YIL048W or YMR162C" - subsystem: + - "Transport [erm, gm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 2 @@ -90895,6 +94042,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YIL048W or YMR162C" - subsystem: + - "Transport [erm, gm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 2 @@ -90908,6 +94056,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YAL026C" - subsystem: + - "Transport [erm, gm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 2 @@ -90921,6 +94070,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YAL026C" - subsystem: + - "Transport [erm, gm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 2 @@ -90934,6 +94084,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YAL026C" - subsystem: + - "Transport [erm, gm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 2 @@ -90947,6 +94098,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YAL026C" - subsystem: + - "Transport [erm, gm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 2 @@ -90960,6 +94112,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YAL026C" - subsystem: + - "Transport [erm, gm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 2 @@ -90973,6 +94126,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YAL026C" - subsystem: + - "Transport [erm, gm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 2 @@ -90986,6 +94140,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YAL026C" - subsystem: + - "Transport [erm, gm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 2 @@ -90999,6 +94154,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YAL026C" - subsystem: + - "Transport [erm, gm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 2 @@ -91011,6 +94167,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, vm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -91023,6 +94180,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, vm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -91035,6 +94193,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, vm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -91047,6 +94206,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, vm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -91059,6 +94219,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, vm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -91071,6 +94232,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, vm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -91083,6 +94245,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, vm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -91095,6 +94258,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, vm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -91107,6 +94271,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, vm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -91119,6 +94284,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, vm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -91131,6 +94297,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, vm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -91143,6 +94310,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, vm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -91155,6 +94323,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, vm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -91167,6 +94336,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, vm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -91179,6 +94349,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, vm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -91191,6 +94362,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, vm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -91203,6 +94375,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, vm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -91215,6 +94388,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, vm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -91227,6 +94401,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, vm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -91239,6 +94414,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, vm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -91251,6 +94427,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, vm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -91263,6 +94440,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, vm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -91275,6 +94453,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, vm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -91287,6 +94466,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, vm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -91299,6 +94479,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, vm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -91311,6 +94492,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, vm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -91323,6 +94505,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, vm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -91335,6 +94518,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, vm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -91347,6 +94531,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, vm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -91359,6 +94544,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, vm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -91371,6 +94557,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, vm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -91383,6 +94570,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, vm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -91395,6 +94583,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, vm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -91407,6 +94596,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, vm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -91419,6 +94609,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, vm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -91431,6 +94622,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, vm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -91443,6 +94635,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, vm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -91455,6 +94648,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, vm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -91467,6 +94661,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, vm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -91479,6 +94674,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, vm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -91491,6 +94687,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [ce, erm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -91503,6 +94700,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [ce, erm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -91515,6 +94713,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [ce, erm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -91527,6 +94726,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [ce, erm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -91539,6 +94739,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [ce, erm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -91551,6 +94752,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [ce, erm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -91563,6 +94765,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [ce, erm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -91575,6 +94778,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [ce, erm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -91587,6 +94791,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [ce, erm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -91599,6 +94804,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [ce, erm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -91611,6 +94817,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [ce, erm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -91623,6 +94830,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [ce, erm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -91635,6 +94843,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [ce, erm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -91647,6 +94856,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [ce, erm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -91659,6 +94869,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [ce, erm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -91671,6 +94882,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [ce, erm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -91684,6 +94896,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YAL026C" - subsystem: + - "Transport [ce, erm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 2 @@ -91697,6 +94910,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YAL026C" - subsystem: + - "Transport [ce, erm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 2 @@ -91710,6 +94924,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YAL026C" - subsystem: + - "Transport [ce, erm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 2 @@ -91723,6 +94938,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YAL026C" - subsystem: + - "Transport [ce, erm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 2 @@ -91736,6 +94952,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YAL026C" - subsystem: + - "Transport [ce, erm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 2 @@ -91749,6 +94966,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YAL026C" - subsystem: + - "Transport [ce, erm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 2 @@ -91762,6 +94980,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YAL026C" - subsystem: + - "Transport [ce, erm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 2 @@ -91775,6 +94994,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YAL026C" - subsystem: + - "Transport [ce, erm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 2 @@ -91788,6 +95008,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YIL048W" - subsystem: + - "Transport [ce, erm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 2 @@ -91801,6 +95022,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YIL048W" - subsystem: + - "Transport [ce, erm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 2 @@ -91814,6 +95036,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YIL048W" - subsystem: + - "Transport [ce, erm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 2 @@ -91827,6 +95050,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YIL048W" - subsystem: + - "Transport [ce, erm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 2 @@ -91840,6 +95064,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YIL048W" - subsystem: + - "Transport [ce, erm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 2 @@ -91853,6 +95078,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YIL048W" - subsystem: + - "Transport [ce, erm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 2 @@ -91866,6 +95092,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YIL048W" - subsystem: + - "Transport [ce, erm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 2 @@ -91879,6 +95106,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YIL048W" - subsystem: + - "Transport [ce, erm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 2 @@ -91891,6 +95119,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [ce, erm]" - annotation: !!omap - metanetx.reaction: "MNXR128298" - sbo: "SBO:0000655" @@ -91904,6 +95133,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [ce, erm]" - annotation: !!omap - metanetx.reaction: "MNXR136128" - sbo: "SBO:0000655" @@ -91917,6 +95147,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [ce, erm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -91929,6 +95160,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [ce, erm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -91941,6 +95173,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [ce, erm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -91953,6 +95186,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [ce, erm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -91965,6 +95199,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [ce, erm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -91977,6 +95212,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [ce, erm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -91989,6 +95225,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [ce, erm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -92001,6 +95238,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [ce, erm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -92013,6 +95251,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [ce, erm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -92025,6 +95264,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [ce, erm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -92037,6 +95277,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [ce, erm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -92049,6 +95290,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [ce, erm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -92061,6 +95303,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [ce, erm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -92073,6 +95316,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [ce, erm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -92085,6 +95329,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [ce, erm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -92097,6 +95342,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [ce, erm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -92109,6 +95355,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [ce, erm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -92121,6 +95368,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [ce, erm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -92133,6 +95381,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [ce, erm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -92145,6 +95394,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [ce, erm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -92157,6 +95407,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [ce, erm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -92169,6 +95420,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [ce, erm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -92181,6 +95433,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [ce, erm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -92193,6 +95446,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [ce, erm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -92205,6 +95459,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [ce, erm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -92217,6 +95472,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [ce, erm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -92229,6 +95485,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, n]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -92241,6 +95498,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, n]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -92253,6 +95511,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, n]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -92265,6 +95524,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, n]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -92277,6 +95537,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, n]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -92289,6 +95550,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, n]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -92301,6 +95563,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, n]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -92313,6 +95576,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, n]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -92325,6 +95589,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, er]" - annotation: !!omap - metanetx.reaction: "MNXR128298" - sbo: "SBO:0000655" @@ -92338,6 +95603,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, er]" - annotation: !!omap - metanetx.reaction: "MNXR136128" - sbo: "SBO:0000655" @@ -92351,6 +95617,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [erm, er]" - annotation: !!omap - metanetx.reaction: "MNXR97950" - sbo: "SBO:0000655" @@ -92364,6 +95631,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Transport [erm, er]" - annotation: !!omap - metanetx.reaction: "MNXR102871" - sbo: "SBO:0000655" @@ -92377,6 +95645,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [vm, gm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -92389,6 +95658,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [vm, gm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -92401,6 +95671,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [vm, gm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -92413,6 +95684,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [vm, gm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -92425,6 +95697,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [vm, gm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -92437,6 +95710,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [vm, gm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -92449,6 +95723,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [vm, gm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -92461,6 +95736,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [vm, gm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -92473,6 +95749,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [vm, ce]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -92485,6 +95762,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [vm, ce]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -92497,6 +95775,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [vm, ce]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -92509,6 +95788,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [vm, ce]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -92521,6 +95801,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [vm, ce]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -92533,6 +95814,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [vm, ce]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -92545,6 +95827,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [vm, ce]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -92557,6 +95840,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [vm, ce]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -92569,6 +95853,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [m, mm]" - annotation: !!omap - metanetx.reaction: "MNXR100765" - sbo: "SBO:0000655" @@ -92582,6 +95867,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [m, mm]" - annotation: !!omap - metanetx.reaction: "MNXR100308" - sbo: "SBO:0000655" @@ -92596,6 +95882,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YBR192W" - subsystem: + - "Transport [m, mm]" - annotation: !!omap - metanetx.reaction: "MNXR96806" - sbo: "SBO:0000655" @@ -92610,6 +95897,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YBR192W" - subsystem: + - "Transport [m, mm]" - annotation: !!omap - metanetx.reaction: "MNXR96946" - sbo: "SBO:0000655" @@ -92622,8 +95910,9 @@ - s_3228: 1 - lower_bound: -1000 - upper_bound: 1000 - - gene_reaction_rule: "YER053C or YJR077C or YLR348C" + - gene_reaction_rule: "YER053C or YJR077C" - subsystem: + - "Transport [m, mm]" - annotation: !!omap - metanetx.reaction: "MNXR102871" - sbo: "SBO:0000655" @@ -92637,6 +95926,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [m, mm]" - annotation: !!omap - metanetx.reaction: "MNXR103112" - sbo: "SBO:0000655" @@ -92652,6 +95942,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -92665,6 +95956,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -92679,6 +95971,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -92693,6 +95986,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -92707,6 +96001,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -92721,6 +96016,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -92735,6 +96031,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -92748,6 +96045,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -92761,6 +96059,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -92774,6 +96073,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -92786,6 +96086,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, erm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 1 @@ -92799,6 +96100,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -92812,6 +96114,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -92825,6 +96128,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -92838,6 +96142,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -92852,6 +96157,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -92865,6 +96171,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -92879,6 +96186,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -92893,6 +96201,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -92907,6 +96216,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -92921,6 +96231,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -92935,6 +96246,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -92948,6 +96260,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -92960,6 +96273,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, erm]" - annotation: !!omap - metanetx.reaction: "MNXR103315" - sbo: "SBO:0000655" @@ -92975,6 +96289,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -92988,6 +96303,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -93002,6 +96318,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -93016,6 +96333,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -93030,6 +96348,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -93044,6 +96363,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -93058,6 +96378,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -93071,6 +96392,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -93083,6 +96405,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, erm]" - annotation: !!omap - metanetx.reaction: "MNXR102406" - sbo: "SBO:0000655" @@ -93098,6 +96421,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -93111,6 +96435,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -93125,6 +96450,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -93139,6 +96465,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -93153,6 +96480,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -93167,6 +96495,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -93181,6 +96510,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -93194,6 +96524,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -93206,6 +96537,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, erm]" - annotation: !!omap - metanetx.reaction: "MNXR102505" - sbo: "SBO:0000655" @@ -93221,6 +96553,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -93235,6 +96568,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -93249,6 +96583,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -93264,6 +96599,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -93279,6 +96615,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -93294,6 +96631,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -93309,6 +96647,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -93323,6 +96662,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -93337,6 +96677,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -93352,6 +96693,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -93365,6 +96707,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -93379,6 +96722,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -93393,6 +96737,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -93408,6 +96753,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -93422,6 +96768,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -93436,6 +96783,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -93451,6 +96799,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -93466,6 +96815,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -93480,6 +96830,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -93495,6 +96846,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -93509,6 +96861,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -93523,6 +96876,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -93538,6 +96892,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -93552,6 +96907,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -93567,6 +96923,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -93581,6 +96938,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -93595,6 +96953,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -93609,6 +96968,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -93624,6 +96984,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -93638,6 +96999,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -93652,6 +97014,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -93665,6 +97028,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -93677,6 +97041,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, erm]" - annotation: !!omap - metanetx.reaction: "MNXR104713" - sbo: "SBO:0000655" @@ -93694,6 +97059,7 @@ - gene_reaction_rule: "YBL015W" - eccodes: "3.1.2.1" - subsystem: + - "Pyruvate metabolism" - annotation: !!omap - kegg.pathway: "sce00620" - kegg.reaction: "R10343" @@ -93710,6 +97076,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, m]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 0 @@ -93733,6 +97100,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Growth" - annotation: !!omap - sbo: "SBO:0000629" - confidence_score: 1 @@ -93747,6 +97115,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Histidine metabolism" - annotation: !!omap - kegg.reaction: "R02410" - metanetx.reaction: "MNXR103420" @@ -93761,6 +97130,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_raffin_e" - sbo: "SBO:0000627" @@ -93772,6 +97142,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_melib_e" - sbo: "SBO:0000627" @@ -93788,6 +97159,7 @@ - gene_reaction_rule: "YDR400W" - eccodes: "3.2.2.3" - subsystem: + - "Pyrimidine metabolism" - annotation: !!omap - bigg.reaction: "URIH" - kegg.pathway: @@ -93810,6 +97182,7 @@ - lower_bound: 0.7 - upper_bound: 0.7 - subsystem: + - "Growth" - annotation: !!omap - bigg.reaction: "ATPM" - sbo: "SBO:0000630" @@ -93862,6 +97235,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Growth" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -93878,6 +97252,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Growth" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -93893,6 +97268,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Growth" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -93908,6 +97284,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Growth" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -93920,6 +97297,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Transport [c, g]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 1 @@ -93932,6 +97310,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Transport [c, g]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 1 @@ -93944,6 +97323,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Transport [c, g]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 1 @@ -93956,6 +97336,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Transport [c, g]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 1 @@ -93968,6 +97349,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Transport [c, er]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 1 @@ -93980,6 +97362,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Transport [c, er]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 1 @@ -93992,6 +97375,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Transport [c, erm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 1 @@ -94004,6 +97388,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Transport [c, erm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 1 @@ -94016,6 +97401,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Transport [c, erm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 1 @@ -94028,6 +97414,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Transport [c, mm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 1 @@ -94040,6 +97427,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Transport [c, mm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 1 @@ -94051,6 +97439,7 @@ - lower_bound: 0 - upper_bound: 0 - subsystem: + - "Exchange reaction" - annotation: !!omap - sbo: "SBO:0000632" - !!omap @@ -94069,6 +97458,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -94080,6 +97470,7 @@ - lower_bound: 0 - upper_bound: 0 - subsystem: + - "Exchange reaction" - annotation: !!omap - sbo: "SBO:0000632" - !!omap @@ -94094,6 +97485,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -94108,6 +97500,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -94122,6 +97515,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -94136,6 +97530,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -94150,6 +97545,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -94164,6 +97560,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -94178,6 +97575,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -94192,6 +97590,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -94206,6 +97605,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -94220,6 +97620,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -94234,6 +97635,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -94247,6 +97649,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -94260,6 +97663,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -94273,6 +97677,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -94286,6 +97691,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -94300,6 +97706,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -94314,6 +97721,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -94327,6 +97735,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -94341,6 +97750,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -94355,6 +97765,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -94369,6 +97780,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -94383,6 +97795,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -94396,6 +97809,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -94410,6 +97824,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -94424,6 +97839,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -94437,6 +97853,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -94451,6 +97868,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -94465,6 +97883,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -94479,6 +97898,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -94493,6 +97913,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "SLIME reaction" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -94506,6 +97927,7 @@ - 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eccodes: "3.4.11.22" - subsystem: + - "Dipeptidases" - annotation: !!omap - sbo: "SBO:0000176" - confidence_score: 2 @@ -96233,6 +99762,7 @@ - gene_reaction_rule: "YKL103C" - eccodes: "3.4.11.22" - subsystem: + - "Dipeptidases" - annotation: !!omap - sbo: "SBO:0000176" - confidence_score: 2 @@ -96252,6 +99782,7 @@ - gene_reaction_rule: "YKL215C" - eccodes: "3.5.2.9" - subsystem: + - "Glutathione metabolism" - annotation: !!omap - bigg.reaction: "OPAH" - kegg.reaction: "R00251" @@ -96270,6 +99801,7 @@ - gene_reaction_rule: "YKL218C" - eccodes: "4.3.1.16" - subsystem: + - "Alanine, aspartate and glutamate metabolism" - annotation: !!omap - kegg.reaction: "R05758" - metanetx.reaction: "MNXR109814" @@ -96288,6 +99820,7 @@ - gene_reaction_rule: "YGR154C" - eccodes: "2.5.1.18" - subsystem: + - "Glutathione metabolism" - annotation: !!omap - kegg.reaction: "R03522" - metanetx.reaction: "MNXR125877" @@ -96308,6 +99841,7 @@ - "2.5.1.18" - "1.8.5.1" - subsystem: + - "Glutathione metabolism" - annotation: !!omap - bigg.reaction: "GTHDH" - kegg.reaction: "R01108" @@ -96329,6 +99863,7 @@ - "2.5.1.18" - "1.8.5.1" - subsystem: + - "Glutathione metabolism" - annotation: !!omap - kegg.reaction: "R01108" - metanetx.reaction: "MNXR138490" @@ -96346,6 +99881,7 @@ - gene_reaction_rule: "YFL061W or YNL335W" - eccodes: "4.2.1.69" - subsystem: + - "Alternate carbon metabolism" - annotation: !!omap - kegg.reaction: "R00778" - metanetx.reaction: "MNXR106683" @@ -96370,6 +99906,7 @@ - "4.3.3.6" - "3.5.1.2" - subsystem: + - "Vitamin b6 metabolism" - annotation: !!omap - kegg.reaction: "R10089" - metanetx.reaction: "MNXR140225" @@ -96394,6 +99931,7 @@ - "4.3.3.6" - "3.5.1.2" - subsystem: + - "Vitamin b6 metabolism" - annotation: !!omap - bigg.reaction: "PYDXS" - kegg.reaction: "R07456" @@ -96413,6 +99951,7 @@ - gene_reaction_rule: "YFR044C" - eccodes: "3.4.13.-" - subsystem: + - "Glutathione metabolism" - annotation: !!omap - bigg.reaction: "AMPTASECG" - kegg.reaction: "R00899" @@ -96432,6 +99971,7 @@ - gene_reaction_rule: "YFR044C" - eccodes: "3.4.13.-" - subsystem: + - "Glutathione metabolism" - annotation: !!omap - kegg.reaction: "R04951" - metanetx.reaction: "MNXR109244" @@ -96450,6 +99990,7 @@ - gene_reaction_rule: "YDL024C" - eccodes: "3.1.3.2" - subsystem: + - "Riboflavin metabolism" - annotation: !!omap - bigg.reaction: "ACP1_FMN" - kegg.reaction: "R00548" @@ -96470,6 +100011,7 @@ - gene_reaction_rule: "YDL120W" - eccodes: "1.16.3.1" - subsystem: + - "Porphyrin and chlorophyll metabolism" - annotation: !!omap - kegg.reaction: "R00078" - metanetx.reaction: "MNXR99561" @@ -96491,6 +100033,7 @@ - "3.1.1.96" - "3.1.1.-" - subsystem: + - "tRNA metabolism" - annotation: !!omap - sbo: "SBO:0000176" - confidence_score: 2 @@ -96510,6 +100053,7 @@ - "3.1.1.96" - "3.1.1.-" - subsystem: + - "tRNA metabolism" - annotation: !!omap - sbo: "SBO:0000176" - confidence_score: 2 @@ -96527,6 +100071,7 @@ - gene_reaction_rule: "YDL236W" - eccodes: "3.1.3.41" - subsystem: + - "Alternate carbon metabolism" - annotation: !!omap - kegg.reaction: "R03024" - metanetx.reaction: "MNXR107896" @@ -96546,6 +100091,7 @@ - gene_reaction_rule: "YDL246C" - eccodes: "1.1.1.14" - subsystem: + - "Pentose and glucuronate interconversions" - annotation: !!omap - bigg.reaction: "RE1317C" - kegg.reaction: "R02896" @@ -96565,6 +100111,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YDR009W" - subsystem: + - "Galactose metabolism" - annotation: !!omap - bigg.reaction: "GALK2" - kegg.reaction: "R01092" @@ -96585,6 +100132,7 @@ - gene_reaction_rule: "YDR036C" - eccodes: "3.1.2.4" - subsystem: + - "Valine, leucine and isoleucine metabolism" - annotation: !!omap - kegg.reaction: "R03352" - metanetx.reaction: "MNXR108112" @@ -96606,6 +100154,7 @@ - gene_reaction_rule: "YDR038C or YDR039C or YDR040C" - eccodes: "3.6.3.7" - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "NAabcO" - sbo: "SBO:0000655" @@ -96626,6 +100175,7 @@ - gene_reaction_rule: "YDR051C or YOL075C" - eccodes: "3.1.3.-" - subsystem: + - "Transport [c, e]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 2 @@ -96642,6 +100192,7 @@ - gene_reaction_rule: "YDR111C" - eccodes: "2.6.1.2" - subsystem: + - "Alanine, aspartate and glutamate metabolism" - annotation: !!omap - bigg.reaction: "ALATA_L" - kegg.reaction: "R00258" @@ -96661,6 +100212,7 @@ - gene_reaction_rule: "YDR242W" - eccodes: "3.5.1.4" - subsystem: + - "Phenylalanine metabolism" - annotation: !!omap - bigg.reaction: "AMID2" - kegg.reaction: "R02540" @@ -96680,6 +100232,7 @@ - gene_reaction_rule: "YDR242W" - eccodes: "3.5.1.4" - subsystem: + - "Tryptophan metabolism" - annotation: !!omap - bigg.reaction: "AMID3" - kegg.reaction: "R03096" @@ -96699,6 +100252,7 @@ - gene_reaction_rule: "YDR242W" - eccodes: "3.5.1.4" - subsystem: + - "Alternate carbon metabolism" - annotation: !!omap - bigg.reaction: "AMID5" - kegg.reaction: "R05551" @@ -96718,6 +100272,7 @@ - gene_reaction_rule: "YDR242W" - eccodes: "3.5.1.4" - subsystem: + - "Other" - annotation: !!omap - sbo: "SBO:0000176" - confidence_score: 2 @@ -96730,11 +100285,12 @@ - s_0434: -1 - s_0794: 1 - s_3875: -1 - - lower_bound: 0 + - lower_bound: -1000 - upper_bound: 1000 - gene_reaction_rule: "YDR248C" - eccodes: "2.7.1.12" - subsystem: + - "Pentose phosphate pathway" - annotation: !!omap - bigg.reaction: "GNK" - kegg.reaction: "R01737" @@ -96754,6 +100310,7 @@ - gene_reaction_rule: "YDR410C" - eccodes: "2.1.1.100" - subsystem: + - "Terpenoid backbone biosynthesis" - annotation: !!omap - kegg.reaction: "R04496" - metanetx.reaction: "MNXR108926" @@ -96773,6 +100330,7 @@ - gene_reaction_rule: "YDR437W and YGR216C and YNL038W and YPL076W and YPL175W and YPL096C-A" - eccodes: "2.4.1.198" - subsystem: + - "Glycosylphosphatidylinositol (gpi)-anchor biosynthesis" - annotation: !!omap - kegg.reaction: "R05916" - metanetx.reaction: "MNXR109940" @@ -96791,6 +100349,7 @@ - gene_reaction_rule: "YDR533C or YMR322C or YOR391C or YPL280W" - eccodes: "4.2.1.130" - subsystem: + - "Pyruvate metabolism" - annotation: !!omap - bigg.reaction: "GLYOX3" - kegg.reaction: "R09796" @@ -96813,6 +100372,7 @@ - gene_reaction_rule: "YGL006W" - eccodes: "3.6.3.8" - subsystem: + - "Transport [c, v]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 2 @@ -96832,6 +100392,7 @@ - gene_reaction_rule: "YGL167C" - eccodes: "3.6.3.8" - subsystem: + - "Transport [c, g]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 2 @@ -96849,6 +100410,7 @@ - gene_reaction_rule: "YGL017W" - eccodes: "2.3.2.8" - subsystem: + - "tRNA metabolism" - annotation: !!omap - kegg.reaction: "R03862" - metanetx.reaction: "MNXR108483" @@ -96868,6 +100430,7 @@ - gene_reaction_rule: "YGL022W" - eccodes: "2.4.99.18" - subsystem: + - "N-glycan biosynthesis" - annotation: !!omap - kegg.reaction: "R05976" - metanetx.reaction: "MNXR109968" @@ -96886,6 +100449,7 @@ - gene_reaction_rule: "YGL027C" - eccodes: "3.2.1.106" - subsystem: + - "N-glycan biosynthesis" - annotation: !!omap - kegg.reaction: "R05979" - metanetx.reaction: "MNXR109970" @@ -96905,6 +100469,7 @@ - gene_reaction_rule: "YGL038C" - eccodes: "2.4.1.232" - subsystem: + - "N-glycan biosynthesis" - annotation: !!omap - kegg.reaction: "R08599" - metanetx.reaction: "MNXR112120" @@ -96926,6 +100491,7 @@ - "2.4.1.132" - "2.4.1.257" - subsystem: + - "N-glycan biosynthesis" - annotation: !!omap - kegg.reaction: "R05973" - metanetx.reaction: "MNXR109280" @@ -96947,6 +100513,7 @@ - "2.4.1.132" - "2.4.1.257" - subsystem: + - "N-glycan biosynthesis" - annotation: !!omap - kegg.reaction: "R06238" - metanetx.reaction: "MNXR110084" @@ -96965,6 +100532,7 @@ - gene_reaction_rule: "YGL156W" - eccodes: "3.2.1.24" - subsystem: + - "Fructose and mannose metabolism" - annotation: !!omap - kegg.reaction: "R09645" - metanetx.reaction: "MNXR101397" @@ -96983,6 +100551,7 @@ - gene_reaction_rule: "YGL156W" - eccodes: "3.2.1.24" - subsystem: + - "Fructose and mannose metabolism" - annotation: !!omap - sbo: "SBO:0000176" - confidence_score: 2 @@ -97001,6 +100570,7 @@ - gene_reaction_rule: "YGL169W" - eccodes: "2.7.7.87" - subsystem: + - "Threonylcarbamoyladenosine metabolism" - annotation: !!omap - kegg.reaction: "R10463" - metanetx.reaction: "MNXR113802" @@ -97018,6 +100588,7 @@ - gene_reaction_rule: "YGL196W" - eccodes: "4.3.1.18" - subsystem: + - "Glycine, serine and threonine metabolism" - annotation: !!omap - bigg.reaction: "SERD_D" - kegg.reaction: "R00221" @@ -97037,6 +100608,7 @@ - gene_reaction_rule: "YGR012W" - eccodes: "2.5.1.47" - subsystem: + - "Cysteine and methionine metabolism" - annotation: !!omap - bigg.reaction: "CYSS_m" - kegg.reaction: "R00897" @@ -97057,6 +100629,7 @@ - gene_reaction_rule: "YGR036C" - eccodes: "3.6.1.43" - subsystem: + - "N-glycan biosynthesis" - annotation: !!omap - kegg.reaction: "R01004" - metanetx.reaction: "MNXR106783" @@ -97076,6 +100649,7 @@ - gene_reaction_rule: "YGR046W" - eccodes: "2.7.7.41" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - kegg.reaction: "R01799" - metanetx.reaction: "MNXR107177" @@ -97095,6 +100669,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YGR144W" - subsystem: + - "Thiamine metabolism" - annotation: !!omap - kegg.reaction: "R10685" - metanetx.reaction: "MNXR139808" @@ -97114,6 +100689,7 @@ - gene_reaction_rule: "YGR227W" - eccodes: "2.4.1.256" - subsystem: + - "N-glycan biosynthesis" - annotation: !!omap - kegg.reaction: "R06264" - metanetx.reaction: "MNXR110098" @@ -97134,6 +100710,7 @@ - gene_reaction_rule: "YGR234W" - eccodes: "1.14.12.17" - subsystem: + - "Nitrogen metabolism" - annotation: !!omap - bigg.reaction: "NODOx" - kegg.reaction: "R05724" @@ -97155,6 +100732,7 @@ - gene_reaction_rule: "YGR234W" - eccodes: "1.14.12.17" - subsystem: + - "Nitrogen metabolism" - annotation: !!omap - bigg.reaction: "NODOy" - kegg.reaction: "R05725" @@ -97175,6 +100753,7 @@ - gene_reaction_rule: "YJL046W" - eccodes: "6.3.1.20" - subsystem: + - "Lipoic acid metabolism" - annotation: !!omap - kegg.reaction: "R07770" - metanetx.reaction: "MNXR101081" @@ -97195,6 +100774,7 @@ - gene_reaction_rule: "YJL046W" - eccodes: "6.3.1.20" - subsystem: + - "Lipoic acid metabolism" - annotation: !!omap - kegg.reaction: "R11143" - metanetx.reaction: "MNXR114442" @@ -97213,6 +100793,7 @@ - gene_reaction_rule: "YJL126W" - eccodes: "3.5.1.-" - subsystem: + - "Glutathione metabolism" - annotation: !!omap - kegg.reaction: "R12024" - sbo: "SBO:0000176" @@ -97230,6 +100811,7 @@ - gene_reaction_rule: "YJL126W" - eccodes: "3.5.1.-" - subsystem: + - "Glutathione metabolism" - annotation: !!omap - kegg.reaction: "R12024" - sbo: "SBO:0000176" @@ -97245,6 +100827,7 @@ - gene_reaction_rule: "YJL200C" - eccodes: "4.2.1.-" - subsystem: + - "Lysine metabolism" - annotation: !!omap - bigg.reaction: "ACONTm" - kegg.reaction: "R01324" @@ -97261,6 +100844,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YJR040W" - subsystem: + - "Transport [c, g]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 2 @@ -97278,6 +100862,7 @@ - gene_reaction_rule: "YJR051W" - eccodes: "1.3.1.6" - subsystem: + - "Cellular response to anaerobic conditions" - annotation: !!omap - kegg.reaction: "R00402" - metanetx.reaction: "MNXR106516" @@ -97297,6 +100882,7 @@ - gene_reaction_rule: "YJR069C" - eccodes: "3.6.1.9" - subsystem: + - "Purine metabolism" - annotation: !!omap - kegg.reaction: "R01532" - metanetx.reaction: "MNXR107043" @@ -97316,6 +100902,7 @@ - gene_reaction_rule: "YJR069C" - eccodes: "3.6.1.9" - subsystem: + - "Purine metabolism" - annotation: !!omap - bigg.reaction: "NTPP5" - sbo: "SBO:0000176" @@ -97334,6 +100921,7 @@ - gene_reaction_rule: "YJR069C" - eccodes: "3.6.1.9" - subsystem: + - "Purine metabolism" - annotation: !!omap - bigg.reaction: "NTPP1" - kegg.reaction: "R01855" @@ -97354,6 +100942,7 @@ - gene_reaction_rule: "YJR069C" - eccodes: "3.6.1.9" - subsystem: + - "Purine metabolism" - annotation: !!omap - bigg.reaction: "NTPP7" - kegg.reaction: "R11323" @@ -97374,6 +100963,7 @@ - gene_reaction_rule: "YJR069C" - eccodes: "3.6.1.9" - subsystem: + - "Purine metabolism" - annotation: !!omap - sbo: "SBO:0000176" - confidence_score: 2 @@ -97390,6 +100980,7 @@ - gene_reaction_rule: "YJR104C" - eccodes: "1.15.1.1" - subsystem: + - "Superoxide metabolism" - annotation: !!omap - bigg.reaction: "SPODM" - kegg.reaction: "R00275" @@ -97411,6 +101002,7 @@ - "3.2.1.113" - "3.2.1.-" - subsystem: + - "N-glycan biosynthesis" - annotation: !!omap - kegg.reaction: "R05982" - metanetx.reaction: "MNXR109973" @@ -97431,6 +101023,7 @@ - "3.2.1.113" - "3.2.1.-" - subsystem: + - "N-glycan biosynthesis" - annotation: !!omap - kegg.reaction: "R06722" - metanetx.reaction: "MNXR110483" @@ -97453,6 +101046,7 @@ - gene_reaction_rule: "YJR149W" - eccodes: "1.13.12.16" - subsystem: + - "Nitrogen metabolism" - annotation: !!omap - kegg.reaction: "R00025" - metanetx.reaction: "MNXR106342" @@ -97473,6 +101067,7 @@ - gene_reaction_rule: "YLL058W or YML082W" - eccodes: "2.5.1.48" - subsystem: + - "Cysteine and methionine metabolism" - annotation: !!omap - bigg.reaction: "SHSL4r" - kegg.reaction: "R00999" @@ -97493,6 +101088,7 @@ - gene_reaction_rule: "YLR047C or YKL220C or YLR214W or YNR060W or YOL152W or YOR381W or YOR384W" - eccodes: "1.16.1.7" - subsystem: + - "Porphyrin and chlorophyll metabolism" - annotation: !!omap - kegg.reaction: "R09541" - metanetx.reaction: "MNXR112960" @@ -97512,6 +101108,7 @@ - gene_reaction_rule: "YLL051C" - eccodes: "1.16.1.7" - subsystem: + - "Porphyrin and chlorophyll metabolism" - annotation: !!omap - kegg.reaction: "R09541" - metanetx.reaction: "MNXR112960" @@ -97530,6 +101127,7 @@ - gene_reaction_rule: "YLR099C or YPR139C" - eccodes: "2.3.1.51" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - kegg.reaction: "R00851" - metanetx.reaction: "MNXR106715" @@ -97551,6 +101149,7 @@ - gene_reaction_rule: "YLR143W" - eccodes: "6.3.1.14" - subsystem: + - "Peptidyl-diphthamide biosynthetic process" - annotation: !!omap - kegg.reaction: "R03613" - metanetx.reaction: "MNXR108295" @@ -97570,6 +101169,7 @@ - gene_reaction_rule: "YLR151C" - eccodes: "3.6.1.55" - subsystem: + - "DNA repair" - annotation: !!omap - kegg.reaction: "R09832" - metanetx.reaction: "MNXR113234" @@ -97588,6 +101188,7 @@ - gene_reaction_rule: "YLR239C" - eccodes: "2.3.1.181" - subsystem: + - "Lipoic acid metabolism" - annotation: !!omap - kegg.reaction: "R07766" - metanetx.reaction: "MNXR111354" @@ -97606,6 +101207,7 @@ - gene_reaction_rule: "YLR239C" - eccodes: "2.3.1.181" - subsystem: + - "Lipoic acid metabolism" - annotation: !!omap - kegg.reaction: "R07769" - metanetx.reaction: "MNXR111357" @@ -97627,6 +101229,7 @@ - "2.7.1.105" - "3.1.3.46" - subsystem: + - "Fructose and mannose metabolism" - annotation: !!omap - bigg.reaction: "PFK26_1" - kegg.reaction: "R02732" @@ -97647,6 +101250,7 @@ - gene_reaction_rule: "YLR446W" - eccodes: "2.7.1.1" - subsystem: + - "Glycolysis / gluconeogenesis" - annotation: !!omap - kegg.reaction: "R00867" - metanetx.reaction: "MNXR100614" @@ -97666,6 +101270,7 @@ - gene_reaction_rule: "YLR446W" - eccodes: "2.7.1.1" - subsystem: + - "Glycolysis / gluconeogenesis" - annotation: !!omap - bigg.reaction: "GLUK_syn" - kegg.reaction: "R01600" @@ -97686,6 +101291,7 @@ - gene_reaction_rule: "YLR446W" - eccodes: "2.7.1.1" - subsystem: + - "Glycolysis / gluconeogenesis" - annotation: !!omap - bigg.reaction: "GLUKA" - kegg.reaction: "R01786" @@ -97706,6 +101312,7 @@ - gene_reaction_rule: "YLR446W" - eccodes: "2.7.1.1" - subsystem: + - "Glycolysis / gluconeogenesis" - annotation: !!omap - bigg.reaction: "HEX10" - kegg.reaction: "R01961" @@ -97726,6 +101333,7 @@ - gene_reaction_rule: "YLR446W" - eccodes: "2.7.1.1" - subsystem: + - "Glycolysis / gluconeogenesis" - annotation: !!omap - bigg.reaction: "ABFPT" - kegg.reaction: "R03920" @@ -97743,6 +101351,7 @@ - gene_reaction_rule: "YMR099C" - eccodes: "5.1.3.15" - subsystem: + - "Glycolysis / gluconeogenesis" - annotation: !!omap - bigg.reaction: "G6PI_1" - kegg.reaction: "R02739" @@ -97764,6 +101373,7 @@ - gene_reaction_rule: "YMR110C" - eccodes: "1.2.1.3" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - bigg.reaction: "GLYALDDr" - kegg.reaction: "R01752" @@ -97785,6 +101395,7 @@ - gene_reaction_rule: "YMR110C" - eccodes: "1.2.1.3" - subsystem: + - "Arginine and proline metabolism" - annotation: !!omap - bigg.reaction: "4ABUTD" - kegg.reaction: "R01986" @@ -97806,6 +101417,7 @@ - gene_reaction_rule: "YMR110C" - eccodes: "1.2.1.3" - subsystem: + - "Arginine and proline metabolism" - annotation: !!omap - bigg.reaction: "ABUTD" - kegg.reaction: "R02549" @@ -97827,6 +101439,7 @@ - gene_reaction_rule: "YMR110C" - eccodes: "1.2.1.3" - subsystem: + - "Tryptophan metabolism" - annotation: !!omap - bigg.reaction: "ALDD20x" - kegg.reaction: "R02678" @@ -97848,6 +101461,7 @@ - gene_reaction_rule: "YMR110C" - eccodes: "1.2.1.3" - subsystem: + - "Sphingolipid metabolism" - annotation: !!omap - kegg.reaction: "R02940" - metanetx.reaction: "MNXR107839" @@ -97868,6 +101482,7 @@ - gene_reaction_rule: "YMR110C" - eccodes: "1.2.1.3" - subsystem: + - "Ascorbate and aldarate metabolism" - annotation: !!omap - bigg.reaction: "ALDD32" - kegg.reaction: "R02957" @@ -97889,6 +101504,7 @@ - gene_reaction_rule: "YMR110C" - eccodes: "1.2.1.3" - subsystem: + - "Ascorbate and aldarate metabolism" - annotation: !!omap - kegg.reaction: "R03283" - metanetx.reaction: "MNXR108074" @@ -97909,6 +101525,7 @@ - gene_reaction_rule: "YMR110C" - eccodes: "1.2.1.3" - subsystem: + - "Valine, leucine and isoleucine metabolism" - annotation: !!omap - kegg.reaction: "R03869" - metanetx.reaction: "MNXR95762" @@ -97929,6 +101546,7 @@ - gene_reaction_rule: "YMR110C" - eccodes: "1.2.1.3" - subsystem: + - "Histidine metabolism" - annotation: !!omap - kegg.reaction: "R04065" - metanetx.reaction: "MNXR95745" @@ -97949,6 +101567,7 @@ - gene_reaction_rule: "YMR110C" - eccodes: "1.2.1.3" - subsystem: + - "Sphingolipid metabolism" - annotation: !!omap - bigg.reaction: "r0688" - kegg.reaction: "R04506" @@ -97970,6 +101589,7 @@ - gene_reaction_rule: "YMR110C" - eccodes: "1.2.1.3" - subsystem: + - "Tryptophan metabolism" - annotation: !!omap - kegg.reaction: "R04903" - metanetx.reaction: "MNXR109205" @@ -97990,6 +101610,7 @@ - gene_reaction_rule: "YMR110C" - eccodes: "1.2.1.3" - subsystem: + - "Arginine and proline metabolism" - annotation: !!omap - bigg.reaction: "NABTNO" - kegg.reaction: "R05050" @@ -98011,6 +101632,7 @@ - gene_reaction_rule: "YMR110C" - eccodes: "1.2.1.3" - subsystem: + - "Alternate carbon metabolism" - annotation: !!omap - kegg.reaction: "R05237" - metanetx.reaction: "MNXR109413" @@ -98031,6 +101653,7 @@ - gene_reaction_rule: "YMR110C" - eccodes: "1.2.1.3" - subsystem: + - "Alternate carbon metabolism" - annotation: !!omap - kegg.reaction: "R05238" - metanetx.reaction: "MNXR109414" @@ -98051,6 +101674,7 @@ - gene_reaction_rule: "YMR110C" - eccodes: "1.2.1.3" - subsystem: + - "Alternate carbon metabolism" - annotation: !!omap - kegg.reaction: "R05286" - metanetx.reaction: "MNXR109457" @@ -98071,6 +101695,7 @@ - gene_reaction_rule: "YMR110C" - eccodes: "1.2.1.3" - subsystem: + - "Alternate carbon metabolism" - annotation: !!omap - kegg.reaction: "R06366" - metanetx.reaction: "MNXR110183" @@ -98091,6 +101716,7 @@ - gene_reaction_rule: "YMR110C" - eccodes: "1.2.1.3" - subsystem: + - "Insect hormone biosynthesis" - annotation: !!omap - kegg.reaction: "R08146" - metanetx.reaction: "MNXR111724" @@ -98112,6 +101738,7 @@ - gene_reaction_rule: "YMR162C" - eccodes: "3.6.3.1" - subsystem: + - "Transport [erm, gm]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 2 @@ -98129,6 +101756,7 @@ - gene_reaction_rule: "YMR210W" - eccodes: "3.1.1.-" - subsystem: + - "Glycerophospholipid metabolism" - annotation: !!omap - sbo: "SBO:0000176" - confidence_score: 2 @@ -98146,6 +101774,7 @@ - gene_reaction_rule: "YNL048W" - eccodes: "2.4.1.131" - subsystem: + - "N-glycan biosynthesis" - annotation: !!omap - kegg.reaction: "R06127" - metanetx.reaction: "MNXR110030" @@ -98165,6 +101794,7 @@ - gene_reaction_rule: "YNL048W" - eccodes: "2.4.1.131" - subsystem: + - "N-glycan biosynthesis" - annotation: !!omap - kegg.reaction: "R06128" - metanetx.reaction: "MNXR110031" @@ -98184,6 +101814,7 @@ - gene_reaction_rule: "YNL092W" - eccodes: "2.1.1.22" - subsystem: + - "Histidine metabolism" - annotation: !!omap - kegg.reaction: "R02144" - metanetx.reaction: "MNXR107333" @@ -98204,6 +101835,7 @@ - "2.4.1.259" - "2.4.1.261" - subsystem: + - "N-glycan biosynthesis" - annotation: !!omap - kegg.reaction: "R06259" - metanetx.reaction: "MNXR110093" @@ -98224,6 +101856,7 @@ - "2.4.1.259" - "2.4.1.261" - subsystem: + - "N-glycan biosynthesis" - annotation: !!omap - kegg.reaction: "R06261" - metanetx.reaction: "MNXR110095" @@ -98243,6 +101876,7 @@ - gene_reaction_rule: "YNL274C" - eccodes: "1.1.1.26" - subsystem: + - "Glyoxylate and dicarboxylate metabolism" - annotation: !!omap - bigg.reaction: "GLYCLTDx" - kegg.reaction: "R00717" @@ -98262,6 +101896,7 @@ - gene_reaction_rule: "YNR030W" - eccodes: "2.4.1.260" - subsystem: + - "N-glycan biosynthesis" - annotation: !!omap - kegg.reaction: "R06260" - metanetx.reaction: "MNXR110094" @@ -98280,6 +101915,7 @@ - gene_reaction_rule: "YOL157C" - eccodes: "3.2.1.10" - subsystem: + - "Starch and sucrose metabolism" - annotation: !!omap - bigg.reaction: "SUCR" - kegg.reaction: "R00801" @@ -98299,6 +101935,7 @@ - gene_reaction_rule: "YOL157C" - eccodes: "3.2.1.10" - subsystem: + - "Starch and sucrose metabolism" - annotation: !!omap - kegg.reaction: "R01718" - metanetx.reaction: "MNXR107140" @@ -98316,6 +101953,7 @@ - gene_reaction_rule: "YOL157C" - eccodes: "3.2.1.10" - subsystem: + - "Starch and sucrose metabolism" - annotation: !!omap - kegg.reaction: "R01791" - metanetx.reaction: "MNXR107171" @@ -98335,6 +101973,7 @@ - gene_reaction_rule: "YOR002W" - eccodes: "2.4.1.267" - subsystem: + - "N-glycan biosynthesis" - annotation: !!omap - kegg.reaction: "R06262" - metanetx.reaction: "MNXR110096" @@ -98354,6 +101993,7 @@ - gene_reaction_rule: "YOR067C" - eccodes: "2.4.1.265" - subsystem: + - "N-glycan biosynthesis" - annotation: !!omap - kegg.reaction: "R06263" - metanetx.reaction: "MNXR110097" @@ -98373,6 +102013,7 @@ - gene_reaction_rule: "YOR149C" - eccodes: "2.4.1.-" - subsystem: + - "Glycosylphosphatidylinositol (gpi)-anchor biosynthesis" - annotation: !!omap - kegg.reaction: "R07129" - metanetx.reaction: "MNXR110833" @@ -98393,6 +102034,7 @@ - gene_reaction_rule: "YOR196C" - eccodes: "2.8.1.8" - subsystem: + - "Lipoic acid metabolism" - annotation: !!omap - kegg.reaction: "R07767" - metanetx.reaction: "MNXR111355" @@ -98413,6 +102055,7 @@ - gene_reaction_rule: "YOR196C" - eccodes: "2.8.1.8" - subsystem: + - "Lipoic acid metabolism" - annotation: !!omap - kegg.reaction: "R07768" - metanetx.reaction: "MNXR111356" @@ -98429,6 +102072,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YOR226C or YPL135W" - subsystem: + - "Cysteine and methionine metabolism" - annotation: !!omap - sbo: "SBO:0000176" - confidence_score: 2 @@ -98448,6 +102092,7 @@ - "2.8.1.1" - "2.8.1.-" - subsystem: + - "Sulfur metabolism" - annotation: !!omap - bigg.reaction: "CYANSTm" - kegg.reaction: "R01931" @@ -98464,6 +102109,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YOR334W or YPL060W" - subsystem: + - "Transport [c, m]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 2 @@ -98481,6 +102127,7 @@ - gene_reaction_rule: "YPL227C" - eccodes: "2.4.1.117" - subsystem: + - "N-glycan biosynthesis" - annotation: !!omap - kegg.reaction: "R01005" - metanetx.reaction: "MNXR143462" @@ -98496,6 +102143,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YPR003C" - subsystem: + - "Transport [c, er]" - annotation: !!omap - bigg.reaction: "HMR_9626" - sbo: "SBO:0000655" @@ -98514,6 +102162,7 @@ - gene_reaction_rule: "YPR127W" - eccodes: "1.1.1.65" - subsystem: + - "Vitamin b6 metabolism" - annotation: !!omap - bigg.reaction: "PYDXOR" - kegg.reaction: "R01708" @@ -98532,6 +102181,7 @@ - gene_reaction_rule: "YDR371W or YLR286C" - eccodes: "3.2.1.14" - subsystem: + - "Amino sugar and nucleotide sugar metabolism" - annotation: !!omap - kegg.reaction: "R01206" - metanetx.reaction: "MNXR106866" @@ -98547,6 +102197,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YOR161C" - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "CHOLtu" - sbo: "SBO:0000655" @@ -98567,6 +102218,7 @@ - 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kegg.reaction: "R06199" - metanetx.reaction: "MNXR110064" @@ -98676,6 +102333,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YEL004W" - subsystem: + - "Transport [er, g]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 2 @@ -98695,6 +102353,7 @@ - "2.3.1.36" - "2.3.1.48" - subsystem: + - "Phenylalanine metabolism" - annotation: !!omap - sbo: "SBO:0000176" - confidence_score: 2 @@ -98707,6 +102366,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, e]" - annotation: !!omap - metanetx.reaction: "MNXR100319" - sbo: "SBO:0000655" @@ -98723,6 +102383,7 @@ - upper_bound: 1000 - eccodes: "3.1.3.19" - subsystem: + - "Glycerolipid metabolism" - annotation: !!omap - bigg.reaction: "G2PP" - kegg.reaction: "R01043" @@ -98740,6 +102401,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, e]" - annotation: !!omap - metanetx.reaction: "MNXR136678" - sbo: "SBO:0000655" @@ -98756,6 +102418,7 @@ - upper_bound: 1000 - eccodes: "3.1.3.-" - subsystem: + - "Glycine, serine and threonine metabolism" - annotation: !!omap - metanetx.reaction: "MNXR103332" - sbo: "SBO:0000176" @@ -98772,6 +102435,7 @@ - upper_bound: 1000 - eccodes: "3.1.3.-" - subsystem: + - "Purine metabolism" - annotation: !!omap - metanetx.reaction: "MNXR118732" - sbo: "SBO:0000176" @@ -98787,6 +102451,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, e]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 1 @@ -98802,6 +102467,7 @@ - upper_bound: 1000 - eccodes: "3.1.3.6" - subsystem: + - "Purine metabolism" - annotation: !!omap - bigg.reaction: "3NUCLE4" - kegg.reaction: "R02148" @@ -98819,6 +102485,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "3GMPt6" - sbo: "SBO:0000655" @@ -98834,6 +102501,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "2PGLYCt6" - metanetx.reaction: "MNXR94822" @@ -98851,6 +102519,7 @@ - upper_bound: 1000 - eccodes: "3.1.3.18" - subsystem: + - "Glyoxylate and dicarboxylate metabolism" - annotation: !!omap - bigg.reaction: "PGLYCP" - kegg.reaction: "R01334" @@ -98869,6 +102538,7 @@ - upper_bound: 1000 - eccodes: "3.1.3.-" - subsystem: + - "Taurine and hypotaurine metabolism" - annotation: !!omap - metanetx.reaction: "MNXR118734" - sbo: "SBO:0000176" @@ -98882,6 +102552,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, e]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 1 @@ -98897,6 +102568,7 @@ - upper_bound: 1000 - eccodes: "1.13.11.19" - subsystem: + - "Taurine and hypotaurine metabolism" - annotation: !!omap - kegg.reaction: "R02467" - metanetx.reaction: "MNXR107528" @@ -98916,6 +102588,7 @@ - upper_bound: 1000 - eccodes: "1.8.1.3" - subsystem: + - "Sulfur metabolism" - annotation: !!omap - kegg.reaction: "R01681" - metanetx.reaction: "MNXR107116" @@ -98933,6 +102606,7 @@ - upper_bound: 1000 - eccodes: "2.6.1.42" - subsystem: + - "Cysteine and methionine metabolism" - annotation: !!omap - bigg.reaction: "RE2034C" - kegg.reaction: "R10991" @@ -98950,6 +102624,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, e]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 1 @@ -98965,6 +102640,7 @@ - upper_bound: 1000 - eccodes: "3.1.3.-" - subsystem: + - "Pyrimidine metabolism" - annotation: !!omap - metanetx.reaction: "MNXR118730" - sbo: "SBO:0000176" @@ -98980,6 +102656,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, e]" - annotation: !!omap - metanetx.reaction: "MNXR136675" - sbo: "SBO:0000655" @@ -98996,6 +102673,7 @@ - upper_bound: 1000 - eccodes: "3.1.3.6" - subsystem: + - "Pyrimidine metabolism" - annotation: !!omap - bigg.reaction: "3NUCLE2" - kegg.reaction: "R01877" @@ -99013,6 +102691,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "3UMPt6" - metanetx.reaction: "MNXR94982" @@ -99030,6 +102709,7 @@ - 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bigg.reaction: "ARGKr" - kegg.reaction: "R00554" @@ -99123,6 +102808,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "ARGPt6" - metanetx.reaction: "MNXR95947" @@ -99139,6 +102825,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Tyrosine metabolism" - annotation: !!omap - metanetx.reaction: "MNXR104998" - sbo: "SBO:0000176" @@ -99154,6 +102841,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, e]" - annotation: !!omap - metanetx.reaction: "MNXR135003" - sbo: "SBO:0000655" @@ -99170,6 +102858,7 @@ - upper_bound: 1000 - eccodes: "3.1.3.-" - subsystem: + - "Pyrimidine metabolism" - annotation: !!omap - metanetx.reaction: "MNXR118731" - sbo: "SBO:0000176" @@ -99185,6 +102874,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, e]" - annotation: !!omap - metanetx.reaction: "MNXR135010" - sbo: "SBO:0000655" @@ -99199,8 +102889,10 @@ - s_4102: -1 - lower_bound: 0 - upper_bound: 1000 + - gene_reaction_rule: "YGR247W" - eccodes: "3.1.4.37" - subsystem: + - "Cyclic nucleotide metabolism" - annotation: !!omap - metanetx.reaction: "MNXR117327" - sbo: "SBO:0000176" @@ -99216,6 +102908,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, e]" - annotation: !!omap - metanetx.reaction: "MNXR136674" - sbo: "SBO:0000655" @@ -99233,6 +102926,7 @@ - upper_bound: 1000 - eccodes: "3.13.1.-" - subsystem: + - "Cysteine and methionine metabolism" - annotation: !!omap - kegg.reaction: "R00863" - metanetx.reaction: "MNXR123155" @@ -99249,6 +102943,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, e]" - annotation: !!omap - metanetx.reaction: "MNXR137086" - sbo: "SBO:0000655" @@ -99265,6 +102960,7 @@ - upper_bound: 1000 - eccodes: "3.1.3.6" - subsystem: + - "Purine metabolism" - annotation: !!omap - bigg.reaction: "3NUCLE1" - kegg.reaction: "R01562" @@ -99280,6 +102976,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, e]" - annotation: !!omap - metanetx.reaction: "MNXR94857" - sbo: "SBO:0000655" @@ -99296,6 +102993,7 @@ - upper_bound: 1000 - eccodes: "3.2.1.20" - subsystem: + - "Starch and sucrose metabolism" - annotation: !!omap - metanetx.reaction: "MNXR130717" - sbo: "SBO:0000176" @@ -99311,6 +103009,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, e]" - annotation: !!omap - bigg.reaction: "PALAt2" - metanetx.reaction: "MNXR102339" @@ -99328,6 +103027,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Cysteine and methionine metabolism" - annotation: !!omap - metanetx.reaction: "MNXR103637" - sbo: "SBO:0000176" @@ -99343,6 +103043,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, e]" - annotation: !!omap - metanetx.reaction: "MNXR137052" - sbo: "SBO:0000655" @@ -99359,6 +103060,7 @@ - upper_bound: 1000 - eccodes: "1.8.2.2" - subsystem: + - "Oxidative phosphorylation" - annotation: !!omap - kegg.reaction: "R00029" - 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annotation: !!omap - sbo: "SBO:0000176" - confidence_score: 1 @@ -101049,6 +104864,7 @@ - upper_bound: 1000 - eccodes: "1.1.1.11" - subsystem: + - "Pentose and glucuronate interconversions" - annotation: !!omap - bigg.reaction: "ABTDG" - kegg.reaction: "R05604" @@ -101065,6 +104881,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YNL065W" - subsystem: + - "Transport [c, e]" - annotation: !!omap - metanetx.reaction: "MNXR95208" - sbo: "SBO:0000655" @@ -101077,6 +104894,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_meoh_e" - metanetx.reaction: "MNXR101464" @@ -101093,6 +104911,7 @@ - upper_bound: 1000 - eccodes: "3.1.3.-" - subsystem: + - "Purine metabolism" - annotation: !!omap - metanetx.reaction: "MNXR118733" - sbo: "SBO:0000176" @@ -101105,6 +104924,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_L_alagly_e" - sbo: "SBO:0000627" @@ -101116,6 +104936,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - sbo: "SBO:0000627" - !!omap @@ -101126,6 +104947,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_pala_e" - sbo: "SBO:0000627" @@ -101137,6 +104959,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_5dglcn_e" - sbo: "SBO:0000627" @@ -101148,6 +104971,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_tag__D_e" - sbo: "SBO:0000627" @@ -101159,6 +104983,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - sbo: "SBO:0000627" - !!omap @@ -101169,6 +104994,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_g6p_e" - sbo: "SBO:0000627" @@ -101180,6 +105006,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_malttr_e" - sbo: "SBO:0000627" @@ -101191,6 +105018,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_g1p_e" - sbo: "SBO:0000627" @@ -101202,6 +105030,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_madg_e" - sbo: "SBO:0000627" @@ -101213,6 +105042,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_gam_e" - sbo: "SBO:0000627" @@ -101224,6 +105054,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_dha_e" - sbo: "SBO:0000627" @@ -101235,6 +105066,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_ala_L_gln__L_e" - sbo: "SBO:0000627" @@ -101246,6 +105078,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - sbo: "SBO:0000627" - !!omap @@ -101256,6 +105089,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_gly_gln__L_e" - sbo: "SBO:0000627" @@ -101267,6 +105101,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_ala_L_his__L_e" - sbo: "SBO:0000627" @@ -101278,6 +105113,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_gly_asn__L_e" - sbo: "SBO:0000627" @@ -101289,6 +105125,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_LalaLglu_e" - sbo: "SBO:0000627" @@ -101300,6 +105137,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_gly_met__L_e" - sbo: "SBO:0000627" @@ -101311,6 +105149,7 @@ - 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sbo: "SBO:0000627" @@ -101377,6 +105221,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_cholp_e" - sbo: "SBO:0000627" @@ -101388,6 +105233,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - sbo: "SBO:0000627" - !!omap @@ -101398,6 +105244,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_2pg_e" - sbo: "SBO:0000627" @@ -101409,6 +105256,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_gmp_e" - sbo: "SBO:0000627" @@ -101420,6 +105268,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_pser__L_e" - sbo: "SBO:0000627" @@ -101431,6 +105280,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_pser__D_e" - sbo: "SBO:0000627" @@ -101442,6 +105292,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_ppi_e" - sbo: "SBO:0000627" @@ -101453,6 +105304,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - sbo: "SBO:0000627" - !!omap @@ -101463,6 +105315,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_pep_e" - sbo: "SBO:0000627" @@ -101474,6 +105327,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_argp_e" - sbo: "SBO:0000627" @@ -101485,6 +105339,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - sbo: "SBO:0000627" - !!omap @@ -101495,6 +105350,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_ethamp_e" - sbo: "SBO:0000627" @@ -101506,6 +105362,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - sbo: "SBO:0000627" - !!omap @@ -101516,6 +105373,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - sbo: "SBO:0000627" - !!omap @@ -101526,6 +105384,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_glyc2p_e" - sbo: "SBO:0000627" @@ -101537,6 +105396,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_3gmp_e" - sbo: "SBO:0000627" @@ -101548,6 +105408,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_2pglyc_e" - sbo: "SBO:0000627" @@ -101559,6 +105420,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_6pgc_e" - sbo: "SBO:0000627" @@ -101570,6 +105432,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_man6p_e" - sbo: "SBO:0000627" @@ -101581,6 +105444,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_23cgmp_e" - sbo: "SBO:0000627" @@ -101592,6 +105456,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_tyrp_e" - sbo: "SBO:0000627" @@ -101603,6 +105468,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_thrp_e" - sbo: "SBO:0000627" @@ -101614,6 +105480,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_3pg_e" - sbo: "SBO:0000627" @@ -101625,6 +105492,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - sbo: "SBO:0000627" - !!omap @@ -101635,6 +105503,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_3amp_e" - sbo: "SBO:0000627" @@ -101646,6 +105515,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_23camp_e" - sbo: "SBO:0000627" @@ -101657,6 +105527,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_man1p_e" - sbo: "SBO:0000627" @@ -101668,6 +105539,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_amp_e" - sbo: "SBO:0000627" @@ -101679,6 +105551,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_C02712_e" - sbo: "SBO:0000627" @@ -101690,6 +105563,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_metsox_S__L_e" - sbo: "SBO:0000627" @@ -101701,6 +105575,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - sbo: "SBO:0000627" - !!omap @@ -101711,6 +105586,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_CE1310_e" - sbo: "SBO:0000627" @@ -101722,6 +105598,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_Lcyst_e" - sbo: "SBO:0000627" @@ -101733,6 +105610,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_isetac_e" - sbo: "SBO:0000627" @@ -101744,6 +105622,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_acac_e" - sbo: "SBO:0000627" @@ -101755,6 +105634,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_acglu_e" - sbo: "SBO:0000627" @@ -101766,6 +105646,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_ump_e" - sbo: "SBO:0000627" @@ -101777,6 +105658,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_cmp_e" - sbo: "SBO:0000627" @@ -101788,6 +105670,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - sbo: "SBO:0000627" - !!omap @@ -101798,6 +105681,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - sbo: "SBO:0000627" - !!omap @@ -101808,6 +105692,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - sbo: "SBO:0000627" - !!omap @@ -101818,6 +105703,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - sbo: "SBO:0000627" - !!omap @@ -101828,6 +105714,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_3ump_e" - sbo: "SBO:0000627" @@ -101839,6 +105726,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_23ccmp_e" - sbo: "SBO:0000627" @@ -101850,27 +105738,10 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_23cump_e" - sbo: "SBO:0000627" - - !!omap - - id: "r_4566" - - name: "ATP:D-Gluconate 6-phosphotransferase" - - metabolites: !!omap - - s_0340: -1 - - s_0394: -1 - - s_0434: 1 - - s_0794: -1 - - s_3875: 1 - - lower_bound: 0 - - upper_bound: 1000 - - eccodes: "2.7.1.12" - - subsystem: - - annotation: !!omap - - kegg.reaction: "R01737" - - metanetx.reaction: "MNXR100390" - - sbo: "SBO:0000176" - - confidence_score: 0 - !!omap - id: "r_4567" - name: "6-phosphogluconate phosphatase" @@ -101886,6 +105757,7 @@ - "3.1.3.2" - "3.1.3.29" - subsystem: + - "Pentose phosphate pathway" - annotation: !!omap - metanetx.reaction: "MNXR123213" - sbo: "SBO:0000176" @@ -101900,6 +105772,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Phenylalanine metabolism" - annotation: !!omap - kegg.reaction: "R06790" - metanetx.reaction: "MNXR139469" @@ -101920,6 +105793,7 @@ - "3.1.1.-" - "3.1.1.2" - subsystem: + - "Alternate carbon metabolism" - annotation: !!omap - kegg.reaction: "R06893" - metanetx.reaction: "MNXR110621" @@ -101936,8 +105810,10 @@ - s_4182: -1 - lower_bound: -1000 - upper_bound: 1000 + - gene_reaction_rule: "YIL074C or YER081W" - eccodes: "1.1.1.95" - subsystem: + - "Glycine, serine and threonine metabolism" - annotation: !!omap - kegg.reaction: "R08198" - metanetx.reaction: "MNXR111769" @@ -101956,6 +105832,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Glyoxylate and dicarboxylate metabolism" - annotation: !!omap - metanetx.reaction: "MNXR134240" - sbo: "SBO:0000176" @@ -101974,6 +105851,7 @@ - "2.6.1.19" - "2.6.1.55" - subsystem: + - "Beta-alanine metabolism" - annotation: !!omap - kegg.reaction: "R00908" - metanetx.reaction: "MNXR95862" @@ -101996,6 +105874,7 @@ - "1.2.1.18" - "1.2.1.27" - subsystem: + - "Beta-alanine metabolism" - annotation: !!omap - bigg.reaction: "MMSAD3" - kegg.reaction: "R00705" @@ -102018,6 +105897,7 @@ - "1.2.1.-" - "1.2.1.18" - subsystem: + - "Beta-alanine metabolism" - annotation: !!omap - kegg.reaction: "R00706" - metanetx.reaction: "MNXR106650" @@ -102037,99 +105917,12 @@ - "4.1.1.-" - "4.2.1.155" - subsystem: + - "Alternate carbon metabolism" - annotation: !!omap - kegg.reaction: "R06973" - metanetx.reaction: "MNXR110693" - sbo: "SBO:0000176" - confidence_score: 0 - - !!omap - - id: "r_4576" - - name: "(R)-2,3-Dihydroxy-3-methylbutanoate:NADP+ oxidoreductase (isomerizing)" - - metabolites: !!omap - - s_0794: 1 - - s_1207: -1 - - s_1212: 1 - - s_4185: -1 - - s_4186: 1 - - lower_bound: -1000 - - upper_bound: 1000 - - eccodes: "1.1.1.86" - - subsystem: - - annotation: !!omap - - kegg.reaction: "R04440" - - metanetx.reaction: "MNXR100904" - - sbo: "SBO:0000176" - - confidence_score: 0 - - !!omap - - id: "r_4577" - - name: "Dihydroxy-acid dehydratase, mitochondrial" - - metabolites: !!omap - - s_0232: -1 - - s_0803: -1 - - s_4208: 1 - - lower_bound: 0 - - upper_bound: 1000 - - subsystem: - - annotation: !!omap - - kegg.reaction: "R01209" - - metanetx.reaction: "MNXR106867" - - sbo: "SBO:0000176" - - confidence_score: 0 - - !!omap - - id: "r_4578" - - name: "Ketol-acid reductoisomerase, mitochondrial" - - metabolites: !!omap - - s_0794: -1 - - s_1207: 1 - - s_1212: -1 - - s_4185: 1 - - s_4187: -1 - - lower_bound: 0 - - upper_bound: 1000 - - subsystem: - - annotation: !!omap - - metanetx.reaction: "MNXR137279" - - sbo: "SBO:0000176" - - confidence_score: 0 - - !!omap - - id: "r_4579" - - name: "pyruvate:pyruvate acetaldehydetransferase (decarboxylating); (S)-2-acetolactate pyruvate-lyase (carboxylating)" - - metabolites: !!omap - - s_0456: 1 - - s_0794: -1 - - s_1399: -2 - - s_4188: 1 - - lower_bound: 0 - - upper_bound: 1000 - - eccodes: "2.2.1.6" - - subsystem: - - annotation: !!omap - - bigg.reaction: "ACLS" - - kegg.reaction: "R00226" - - metanetx.reaction: "MNXR95271" - - sbo: "SBO:0000176" - - confidence_score: 0 - - !!omap - - id: "r_4580" - - name: "(R)-2,3-dihydroxy-3-methylbutanoate:NADP+ oxidoreductase (isomerizing)" - - metabolites: !!omap - - s_0794: 1 - - s_1207: -1 - - s_1212: 1 - - s_4185: -1 - - s_4188: 1 - - lower_bound: -1000 - - upper_bound: 1000 - - eccodes: - - "1.1.1.383" - - "1.1.1.86" - - subsystem: - - annotation: !!omap - - bigg.reaction: "KARA1" - - kegg.reaction: "R04439" - - metanetx.reaction: "MNXR97523" - - sbo: "SBO:0000176" - - confidence_score: 0 - !!omap - id: "r_4581" - name: "(2R,3S)-3-methylmalate:NAD+ oxidoreductase" @@ -102145,6 +105938,7 @@ - "1.1.1.-" - "1.1.1.85" - subsystem: + - "Valine, leucine and isoleucine metabolism" - annotation: !!omap - bigg.reaction: "ERTHMMOR" - kegg.reaction: "R00994" @@ -102165,6 +105959,7 @@ - upper_bound: 1000 - eccodes: "2.3.3.-" - subsystem: + - "Glyoxylate and dicarboxylate metabolism" - annotation: !!omap - metanetx.reaction: "MNXR121603" - sbo: "SBO:0000176" @@ -102184,6 +105979,7 @@ - "3.1.2.-" - "3.1.2.2" - subsystem: + - "Biosynthesis of unsaturated fatty acids" - annotation: !!omap - bigg.reaction: "FACOAE1829Z12Z" - kegg.reaction: "R08177" @@ -102202,8 +105998,10 @@ - s_4191: -1 - lower_bound: 0 - upper_bound: 1000 + - gene_reaction_rule: "YOR317W or YER015W or YMR246W or YIL009W" - eccodes: "6.2.1.3" - subsystem: + - "Fatty acid biosynthesis" - annotation: !!omap - bigg.reaction: "FACOAL1821" - metanetx.reaction: "MNXR99175" @@ -102221,6 +106019,7 @@ - upper_bound: 1000 - eccodes: "3.2.1.22" - subsystem: + - "Galactose metabolism" - annotation: !!omap - bigg.reaction: "STACHGALACT" - kegg.reaction: "R03634" @@ -102238,6 +106037,7 @@ - upper_bound: 1000 - eccodes: "2.4.1.-" - subsystem: + - "Galactose metabolism" - annotation: !!omap - metanetx.reaction: "MNXR122225" - sbo: "SBO:0000176" @@ -102254,6 +106054,7 @@ - upper_bound: 1000 - gene_reaction_rule: "YOL122C" - 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subsystem: + - "Growth" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -102433,6 +106245,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Growth" - annotation: !!omap - sbo: "SBO:0000395" - confidence_score: 1 @@ -102444,6 +106257,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - bigg.reaction: "EX_ca2_e" - sbo: "SBO:0000627" @@ -102458,6 +106272,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, p]" - annotation: !!omap - metanetx.reaction: "MNXR94845" - sbo: "SBO:0000655" @@ -102471,6 +106286,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, er]" - annotation: !!omap - metanetx.reaction: "MNXR95431" - sbo: "SBO:0000655" @@ -102484,6 +106300,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, n]" - annotation: !!omap - bigg.reaction: "ADPRIBt" - metanetx.reaction: "MNXR95481" @@ -102498,6 +106315,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, lp]" - annotation: !!omap - metanetx.reaction: "MNXR99646" - sbo: "SBO:0000655" @@ -102513,6 +106331,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, m]" - annotation: !!omap - metanetx.reaction: "MNXR101858" - sbo: "SBO:0000655" @@ -102528,6 +106347,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, er]" - annotation: !!omap - metanetx.reaction: "MNXR135002" - sbo: "SBO:0000655" @@ -102541,6 +106361,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, g]" - annotation: !!omap - bigg.reaction: "PItg" - metanetx.reaction: "MNXR102871" @@ -102560,6 +106381,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Transport [c, m]" - annotation: !!omap - bigg.reaction: "r2499" - metanetx.reaction: "MNXR106312" @@ -102574,6 +106396,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, g]" - annotation: !!omap - bigg.reaction: "UDPtg" - metanetx.reaction: "MNXR105076" @@ -102588,6 +106411,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, n]" - annotation: !!omap - bigg.reaction: "UDPtg" - metanetx.reaction: "MNXR105076" @@ -102602,6 +106426,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, g]" - annotation: !!omap - metanetx.reaction: "MNXR105127" - sbo: "SBO:0000655" @@ -102615,6 +106440,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, n]" - annotation: !!omap - metanetx.reaction: "MNXR104921" - sbo: "SBO:0000655" @@ -102628,6 +106454,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, m]" - annotation: !!omap - metanetx.reaction: "MNXR99110" - sbo: "SBO:0000655" @@ -102643,6 +106470,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, n]" - annotation: !!omap - bigg.reaction: "ACTNt2r" - metanetx.reaction: "MNXR95426" @@ -102657,6 +106485,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, m]" - annotation: !!omap - bigg.reaction: "GLNtm" - metanetx.reaction: "MNXR100259" @@ -102671,6 +106500,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, er]" - annotation: !!omap - metanetx.reaction: "MNXR105127" - sbo: "SBO:0000655" @@ -102684,6 +106514,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, n]" - annotation: !!omap - bigg.reaction: "AMETtn" - metanetx.reaction: "MNXR95809" @@ -102698,6 +106529,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, er]" - annotation: !!omap - metanetx.reaction: "MNXR100449" - sbo: "SBO:0000655" @@ -102714,6 +106546,7 @@ - upper_bound: 1000 - eccodes: "2.7.4.6" - subsystem: + - "Transport [c, v]" - annotation: !!omap - metanetx.reaction: "MNXR96123" - sbo: "SBO:0000655" @@ -102727,6 +106560,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, v]" - annotation: !!omap - metanetx.reaction: "MNXR101385" - sbo: "SBO:0000655" @@ -102740,6 +106574,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, m]" - annotation: !!omap - bigg.reaction: "ACSERtmi" - metanetx.reaction: "MNXR95416" @@ -102754,6 +106589,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, m]" - annotation: !!omap - metanetx.reaction: "MNXR100494" - sbo: "SBO:0000655" @@ -102769,6 +106605,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, m]" - annotation: !!omap - metanetx.reaction: "MNXR97002" - sbo: "SBO:0000655" @@ -102785,6 +106622,7 @@ - upper_bound: 1000 - eccodes: "2.7.4.6" - subsystem: + - "Transport [c, erm]" - annotation: !!omap - metanetx.reaction: "MNXR96123" - sbo: "SBO:0000655" @@ -102798,6 +106636,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, m]" - annotation: !!omap - metanetx.reaction: "MNXR104966" - sbo: "SBO:0000655" @@ -102811,6 +106650,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, m]" - annotation: !!omap - metanetx.reaction: "MNXR104460" - sbo: "SBO:0000655" @@ -102824,6 +106664,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, er]" - annotation: !!omap - metanetx.reaction: "MNXR105071" - sbo: "SBO:0000655" @@ -102837,6 +106678,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, g]" - annotation: !!omap - metanetx.reaction: "MNXR105021" - sbo: "SBO:0000655" @@ -102854,6 +106696,7 @@ - gene_reaction_rule: "YBR177C or YPL095C" - eccodes: "2.3.1.84" - subsystem: + - "Fatty acid ester pathway" - annotation: !!omap - kegg.reaction: "R00627" - sbo: "SBO:0000176" @@ -102871,6 +106714,7 @@ - gene_reaction_rule: "YBR177C or YPL095C" - eccodes: "2.3.1.84" - subsystem: + - "Fatty acid ester pathway" - annotation: !!omap - kegg.reaction: "R00627" - sbo: "SBO:0000176" @@ -102888,6 +106732,7 @@ - gene_reaction_rule: "YBR177C or YPL095C" - eccodes: "2.3.1.84" - subsystem: + - "Fatty acid ester pathway" - annotation: !!omap - kegg.reaction: "R00627" - sbo: "SBO:0000176" @@ -102905,6 +106750,7 @@ - gene_reaction_rule: "YGR177C or YOR377W or YGR015C" - eccodes: "2.3.1.84" - subsystem: + - "Fatty acid ester pathway" - annotation: !!omap - kegg.reaction: "R00627" - sbo: "SBO:0000176" @@ -102922,6 +106768,7 @@ - gene_reaction_rule: "YBR177C or YPL095C" - eccodes: "2.3.1.84" - subsystem: + - "Fatty acid ester pathway" - annotation: !!omap - kegg.reaction: "R00627" - sbo: "SBO:0000176" @@ -102935,6 +106782,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, m]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 2 @@ -102947,6 +106795,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, m]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 2 @@ -102959,6 +106808,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, m]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 2 @@ -102971,6 +106821,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Transport [c, m]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 2 @@ -102983,6 +106834,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Transport [c, m]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 2 @@ -102995,6 +106847,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, e]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 2 @@ -103007,6 +106860,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, e]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 2 @@ -103019,6 +106873,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, e]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 2 @@ -103031,6 +106886,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Transport [c, e]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 2 @@ -103043,6 +106899,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Transport [c, e]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 2 @@ -103054,6 +106911,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - sbo: "SBO:0000627" - confidence_score: 2 @@ -103065,6 +106923,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - sbo: "SBO:0000627" - confidence_score: 2 @@ -103076,6 +106935,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - sbo: "SBO:0000627" - confidence_score: 2 @@ -103087,6 +106947,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - sbo: "SBO:0000627" - confidence_score: 2 @@ -103098,6 +106959,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - sbo: "SBO:0000627" - confidence_score: 2 @@ -103114,6 +106976,7 @@ - gene_reaction_rule: "YGR015C" - eccodes: "2.3.1.268" - subsystem: + - "Fatty acid ester pathway" - annotation: !!omap - kegg.reaction: "R11957" - sbo: "SBO:0000176" @@ -103127,6 +106990,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Transport [c, m]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 2 @@ -103143,6 +107007,7 @@ - gene_reaction_rule: "YGR087C or YLR044C or YLR134W" - eccodes: "4.1.1.1" - subsystem: + - "Fatty acid ester pathway" - annotation: !!omap - kegg.reaction: "R00636" - sbo: "SBO:0000176" @@ -103164,6 +107029,7 @@ - "1.1.1.1" - "1.1.1.284" - subsystem: + - "Fatty acid ester pathway" - annotation: !!omap - kegg.pathway: - "sce00010" @@ -103188,6 +107054,7 @@ - gene_reaction_rule: "YGL256W or YMR083W" - eccodes: "1.1.1.1" - subsystem: + - "Fatty acid ester pathway" - annotation: !!omap - kegg.pathway: - "sce00010" @@ -103213,6 +107080,7 @@ - "1.1.1.-" - "1.1.1.2" - subsystem: + - "Fatty acid ester pathway" - annotation: !!omap - kegg.pathway: - "sce00010" @@ -103231,6 +107099,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, m]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 2 @@ -103243,6 +107112,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, e]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 2 @@ -103255,6 +107125,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, e]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 2 @@ -103266,6 +107137,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - sbo: "SBO:0000627" - confidence_score: 2 @@ -103277,6 +107149,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - sbo: "SBO:0000627" - confidence_score: 2 @@ -103293,6 +107166,7 @@ - gene_reaction_rule: "YHR137W" - eccodes: "4.1.1.1" - subsystem: + - "Fatty acid ester pathway" - annotation: !!omap - kegg.reaction: "R00636" - sbo: "SBO:0000176" @@ -103314,6 +107188,7 @@ - "1.1.1.1" - "1.1.1.284" - subsystem: + - "Fatty acid ester pathway" - annotation: !!omap - kegg.pathway: - "sce00010" @@ -103338,6 +107213,7 @@ - gene_reaction_rule: "YGL256W or YMR083W" - eccodes: "1.1.1.1" - subsystem: + - "Fatty acid ester pathway" - annotation: !!omap - kegg.pathway: - "sce00010" @@ -103363,6 +107239,7 @@ - "1.1.1.-" - "1.1.1.2" - subsystem: + - "Fatty acid ester pathway" - annotation: !!omap - kegg.pathway: - "sce00010" @@ -103381,6 +107258,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, m]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 2 @@ -103393,6 +107271,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, e]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 2 @@ -103405,6 +107284,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, e]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 2 @@ -103416,6 +107296,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - sbo: "SBO:0000627" - confidence_score: 2 @@ -103427,6 +107308,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - sbo: "SBO:0000627" - confidence_score: 2 @@ -103443,6 +107325,7 @@ - gene_reaction_rule: "YGR087C or YLR044C or YLR134W" - eccodes: "4.1.1.1" - subsystem: + - "Fatty acid ester pathway" - annotation: !!omap - sbo: "SBO:0000176" - confidence_score: 2 @@ -103463,6 +107346,7 @@ - "1.1.1.1" - "1.1.1.284" - subsystem: + - "Fatty acid ester pathway" - annotation: !!omap - kegg.pathway: - "sce00010" @@ -103486,6 +107370,7 @@ - gene_reaction_rule: "YGL256W or YMR083W" - eccodes: "1.1.1.1" - subsystem: + - "Fatty acid ester pathway" - annotation: !!omap - kegg.pathway: - "sce00010" @@ -103511,6 +107396,7 @@ - "1.1.1.-" - "1.1.1.2" - subsystem: + - "Fatty acid ester pathway" - annotation: !!omap - kegg.pathway: - "sce00010" @@ -103529,6 +107415,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, m]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 2 @@ -103541,6 +107428,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, e]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 2 @@ -103553,6 +107441,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, e]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 2 @@ -103564,6 +107453,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - sbo: "SBO:0000627" - confidence_score: 2 @@ -103575,6 +107465,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - sbo: "SBO:0000627" - confidence_score: 2 @@ -103593,6 +107484,7 @@ - gene_reaction_rule: "YMR170C or YMR169C or YOR374W" - eccodes: "1.2.1.5" - subsystem: + - "Fatty acid ester pathway" - annotation: !!omap - kegg.pathway: - "sce00010" @@ -103617,6 +107509,7 @@ - gene_reaction_rule: "YOR317W or YER015W or YIL009W or YMR246W" - eccodes: "6.2.1.3" - subsystem: + - "Fatty acid ester pathway" - annotation: !!omap - kegg.pathway: - "sce00061" @@ -103638,6 +107531,7 @@ - gene_reaction_rule: "YBR177C or YPL095C" - eccodes: "2.3.1.84" - subsystem: + - "Fatty acid ester pathway" - annotation: !!omap - sbo: "SBO:0000176" - confidence_score: 2 @@ -103650,6 +107544,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [p, m]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 2 @@ -103662,6 +107557,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [p, m]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 2 @@ -103674,6 +107570,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [p, m]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 2 @@ -103686,6 +107583,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [p, m]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 2 @@ -103698,6 +107596,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [p, m]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 2 @@ -103710,6 +107609,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, p]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 2 @@ -103726,6 +107626,7 @@ - gene_reaction_rule: "YGR177C or YOR377W or YGR015C" - eccodes: "2.3.1.84" - subsystem: + - "Fatty acid ester pathway" - annotation: !!omap - sbo: "SBO:0000176" - confidence_score: 2 @@ -103738,6 +107639,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Transport [c, e]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 2 @@ -103749,6 +107651,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - sbo: "SBO:0000627" - confidence_score: 2 @@ -103765,6 +107668,7 @@ - gene_reaction_rule: "YGR177C or YOR377W or YGR015C" - eccodes: "2.3.1.84" - subsystem: + - "Fatty acid ester pathway" - annotation: !!omap - sbo: "SBO:0000176" - confidence_score: 2 @@ -103777,6 +107681,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Transport [c, e]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 2 @@ -103788,6 +107693,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - sbo: "SBO:0000627" - confidence_score: 2 @@ -103804,6 +107710,7 @@ - gene_reaction_rule: "YGR177C or YOR377W or YGR015C" - eccodes: "2.3.1.84" - subsystem: + - "Fatty acid ester pathway" - annotation: !!omap - sbo: "SBO:0000176" - confidence_score: 2 @@ -103816,6 +107723,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Transport [c, e]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 2 @@ -103827,6 +107735,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - sbo: "SBO:0000627" - confidence_score: 2 @@ -103839,6 +107748,7 @@ - lower_bound: -1000 - upper_bound: 1000 - subsystem: + - "Transport [c, m]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 2 @@ -103850,7 +107760,9 @@ - s_4262: 1 - lower_bound: 0 - upper_bound: 1000 + - gene_reaction_rule: "YNL065W or YKL217W" - subsystem: + - "Transport [c, e]" - annotation: !!omap - sbo: "SBO:0000655" - confidence_score: 2 @@ -103862,6 +107774,7 @@ - lower_bound: 0 - upper_bound: 1000 - subsystem: + - "Exchange reaction" - annotation: !!omap - sbo: "SBO:0000627" - confidence_score: 2 @@ -104262,6 +108175,15 @@ - !!omap - id: "YBR127C" - name: "VMA2" + - !!omap + - id: "YBR128C" + - name: "ATG14" + - annotation: !!omap + - kegg.genes: "sce:YBR128C" + - ncbigene: "852425" + - ncbiprotein: "NP_009686 " + - refseq: "NM_001178476" + - uniprot: "P38270" - !!omap - id: "YBR132C" - name: "AGP2" @@ -104337,6 +108259,14 @@ - !!omap - id: "YBR241C" - name: "YBR241C" + - !!omap + - id: "YBR242W" + - annotation: !!omap + - kegg.genes: "sce:YBR242W" + - ncbigene: "852544" + - ncbiprotein: "NP_009801" + - refseq: "NM_001178590" + - uniprot: "P38331" - !!omap - id: "YBR243C" - name: "ALG7" @@ -105156,6 +109086,15 @@ - !!omap - id: "YFR019W" - name: "FAB1" + - !!omap + - id: "YFR021W" + - name: "ATG18" + - annotation: !!omap + - kegg.genes: "sce:YFR021W" + - ncbigene: "850577" + - ncbiprotein: "NP_444297" + - refseq: "NM_001179986" + - uniprot: "P43601" - !!omap - id: "YFR025C" - name: "HIS2" @@ -105171,6 +109110,15 @@ - !!omap - id: "YFR047C" - name: "BNA6" + - !!omap + - id: "YFR049W" + - name: "YMR31" + - annotation: !!omap + - kegg.genes: "sce:YFR049W" + - ncbigene: "850610" + - ncbiprotein: "NP_116707" + - refseq: "NM_001180014" + - uniprot: "P19955" - !!omap - id: "YFR053C" - name: "HXK1" @@ -105241,11 +109189,14 @@ - id: "YGL084C" - name: "GUP1" - !!omap - - id: "YGL104C" - - name: "VPS73" - - !!omap - - id: "YGL119W" - - name: "COQ8" + - id: "YGL101W" + - name: "YGK1" + - annotation: !!omap + - kegg.genes: "sce:YGL101W" + - ncbigene: "852777" + - ncbiprotein: "NP_011414" + - refseq: "NM_001180966" + - uniprot: "P53144" - !!omap - id: "YGL125W" - name: "MET13" @@ -105336,6 +109287,15 @@ - !!omap - id: "YGR036C" - name: "CAX4" + - !!omap + - id: "YGR038W" + - name: "ORM1" + - annotation: !!omap + - kegg.genes: "sce:YGR038W" + - ncbigene: "852926" + - ncbiprotein: "NP_011552 " + - refseq: "NM_001181167" + - uniprot: "P53224" - !!omap - id: "YGR043C" - name: "NQM1" @@ -105369,6 +109329,15 @@ - !!omap - id: "YGR096W" - name: "TPC1" + - !!omap + - id: "YGR106C" + - name: "VOA1" + - annotation: !!omap + - kegg.genes: "sce:YGR106C" + - ncbigene: "852998" + - ncbiprotein: "NP_011620" + - refseq: "NM_001181235" + - uniprot: "P53262" - !!omap - id: "YGR110W" - name: "CLD1" @@ -105387,9 +109356,6 @@ - !!omap - id: "YGR144W" - name: "THI4" - - !!omap - - id: "YGR147C" - - name: "NAT2" - !!omap - id: "YGR154C" - name: "GTO1" @@ -105744,6 +109710,12 @@ - !!omap - id: "YIL166C" - name: "SOA1" + - annotation: !!omap + - kegg.genes: "sce:YIL166C" + - ncbigene: "854640" + - ncbiprotein: "NP_012100" + - refseq: "NM_001179514" + - uniprot: "P40445" - !!omap - id: "YIL172C" - name: "IMA3" @@ -106356,6 +110328,15 @@ - !!omap - id: "YLR209C" - name: "PNP1" + - !!omap + - id: "YLR211C" + - name: "ATG38" + - annotation: !!omap + - kegg.genes: "sce:YLR211C" + - ncbigene: "850908" + - ncbiprotein: "NP_013312 " + - refseq: "NM_001182098" + - uniprot: "Q05789" - !!omap - id: "YLR214W" - name: "FRE1" @@ -106428,6 +110409,15 @@ - !!omap - id: "YLR348C" - name: "DIC1" + - !!omap + - id: "YLR350W" + - name: "ORM2" + - annotation: !!omap + - kegg.genes: "sce:YLR350W" + - ncbigene: "851064" + - ncbiprotein: "NP_013454 " + - refseq: "NM_001182239" + - uniprot: "Q06144" - !!omap - id: "YLR351C" - name: "NIT3" @@ -106440,6 +110430,15 @@ - !!omap - id: "YLR359W" - name: "ADE13" + - !!omap + - id: "YLR360W" + - name: "VPS38" + - annotation: !!omap + - kegg.genes: "sce:YLR360W" + - ncbigene: "851074" + - ncbiprotein: "NP_013464" + - refseq: "NM_001182249" + - uniprot: "Q05919" - !!omap - id: "YLR372W" - name: "ELO3" @@ -106752,6 +110751,15 @@ - !!omap - id: "YNL052W" - name: "COX5A" + - !!omap + - id: "YNL054W" + - name: "VAC7" + - annotation: !!omap + - kegg.genes: "sce:YNL054W" + - ncbigene: "855673" + - ncbiprotein: "NP_014344" + - refseq: "NM_001182893" + - uniprot: "P53950" - !!omap - id: "YNL065W" - name: "AQR1" @@ -107151,6 +111159,16 @@ - !!omap - id: "YOR251C" - name: "TUM1" + - !!omap + - id: "YOR253W" + - name: "NAT5" + - annotation: !!omap + - ecogene: "2.3.1.258" + - kegg.genes: "sce:YOR253W" + - ncbigene: "854427" + - ncbiprotein: "NP_014896 " + - refseq: "NM_001183672" + - uniprot: "Q08689" - !!omap - id: "YOR270C" - name: "VPH1" @@ -107304,6 +111322,15 @@ - !!omap - id: "YPL117C" - name: "IDI1" + - !!omap + - id: "YPL120W" + - name: "VPS30" + - annotation: !!omap + - kegg.genes: "sce:YPL120W" + - ncbigene: "855983" + - ncbiprotein: "NP_015205" + - refseq: "NM_001183934" + - uniprot: "Q02948" - !!omap - id: "YPL132W" - name: "COX11" @@ -107475,9 +111502,26 @@ - !!omap - id: "YPR160W" - name: "GPH1" + - !!omap + - id: "YPR165W" + - name: "RHO1" + - annotation: !!omap + - kegg.genes: "sce:YPR165W" + - ncbigene: "856294" + - ncbiprotein: "NP_015491" + - refseq: "NM_001184262" + - uniprot: "P06780" - !!omap - id: "YPR167C" - name: "MET16" + - !!omap + - id: "YPR170W-B" + - annotation: !!omap + - kegg.genes: "sce:YPR170W-B" + - ncbigene: "5848745" + - ncbiprotein: "NP_001106949" + - refseq: "NM_001184525" + - uniprot: "P0C5R9" - !!omap - id: "YPR183W" - name: "DPM1" diff --git a/version.txt b/version.txt deleted file mode 100644 index 1acea15a..00000000 --- a/version.txt +++ /dev/null @@ -1 +0,0 @@ -8.6.0 \ No newline at end of file