diff --git a/ComplementaryData/databases/TransRxnGeneAnnotation.tsv b/ComplementaryData/databases/TransRxnGeneAnnotation.tsv new file mode 100644 index 00000000..7ee3ed02 --- /dev/null +++ b/ComplementaryData/databases/TransRxnGeneAnnotation.tsv @@ -0,0 +1,178 @@ +gene rxnID formula annotation_uniprot main_met_mnx other_met annotation_SGD ec_SGD protein_name_SGD ec_uniprot protein_name_uniprot Annotation_score reaction_uniprot annotation_kegg ec_kegg annotation_biocyc annotation_reactome TC_number annotation_TCDB subunit +YGL077C r_1149 ethanolamine[e] <=> ethanolamine[c] Sole choline transporter in yeast. MNXM218 none "Plasma membrane transporter for choline, ethanolamine, and carnitine; involved in the uptake of nitrogen mustard and the uptake of glycine betaine during hypersaline stress; co-regulated with phospholipid biosynthetic genes and negatively regulated by choline and myo-inositol" NA Plasma membrane transporter for choline, ethanolamine, and carnitine NA Choline transport protein 5 out of 5 NA "HNM1, CTR1; Hnm1p" NA Hyper-resistance to Nitrogen Mustard NA 2.A.3.4.1 Choline transport protein - Saccharomyces cerevisiae (Baker's yeast). FALSE +YJL133W r_1179 iron(2+)[c] => iron(2+)[m] MRS3 suppresses a mitochondrial splice defect in the first intron of the COB gene. It may act as a carrier, exerting its suppressor activity via modulation of solute concentrations in the mitochondrion (possibly of cations). MNXM111 none "Iron transporter, mediates Fe2+ transport across inner mito membrane; mitochondrial carrier family member; active under low-iron conditions; may transport other cations; MRS3 has a paralog, MRS4, that arose from the whole genome duplication" NA Iron transporter, mediates Fe2+ transport across inner mito membrane NA Mitochondrial RNA-splicing protein MRS3 4 out of 5 NA "MRS3; Fe(2+) transporter" NA Mitochondrial RNA Splicing MRS3/4 Transports Iron Across the Mitochondrial Inner Membrane 2.A.29.5.1 Mitochondrial RNA-splicing protein MRS3 OS=Saccharomyces cerevisiae GN=MRS3 PE=1 SV=4 FALSE +YKR052C r_1179 iron(2+)[c] => iron(2+)[m] MRS4 suppresses a mitochondrial splice defect in the first intron of the COB gene. It may act as a carrier, exerting its suppressor activity via modulation of solute concentrations in the mitochondrion (possibly of cations). Not essential. MNXM111 none "Iron transporter of the mitochondrial carrier family; mediates Fe2+ transport across the inner mitochondrial membrane; active under low-iron conditions; may transport other cations; protein abundance increases in response to DNA replication stress; MRS4 has a paralog, MRS3, that arose from the whole genome duplication" NA Iron transporter of the mitochondrial carrier family NA Mitochondrial RNA-splicing protein MRS4 4 out of 5 NA "MRS4; Fe(2+) transporter" NA Mitochondrial RNA Splicing MRS3/4 Transports Iron Across the Mitochondrial Inner Membrane 2.A.29.5.2 Mitochondrial RNA splicing protein MRS4 - Saccharomyces cerevisiae (Baker's yeast). FALSE +YKL188C r_1236 stearate[c] <=> stearate[p] Involved in the import of activated long-chain fatty acids from the cytosol to the peroxisomal matrix. {ECO:0000269|PubMed:8670886}. MNXM236 none "Subunit of heterodimeric peroxisomal ABC transport complex, with Pxa1p; required for import of long-chain fatty acids into peroxisomes; similar to human adrenoleukodystrophy transportesr ABCD1 and ABCD2, and ALD-related proteins; mutations in ABCD1 cause X-linked adrenoleukodystrophy (X-ALD), a peroxisomal disorder; human ABCD1 and ABCD2 can each partially complement yeast pxa1 pxa2 double null mutant" NA Subunit of heterodimeric peroxisomal ABC transport complex, with Pxa1p NA Peroxisomal long-chain fatty acid import protein 1 (Peroxisomal ABC transporter 2) 5 out of 5 NA "PXA2, PAT1; ATP-binding cassette long-chain fatty acid transporter PXA2" NA PeroXisomal ABC-transporter NA 3.A.1.203.2 Peroxisomal long-chain fatty acid import protein 1 (Peroxisomal ABC transporter 2) - Saccharomyces cerevisiae (Baker's yeast). TRUE +YPL147W r_1236 stearate[c] <=> stearate[p] Involved in the import of activated long-chain fatty acids from the cytosol to the peroxisomal matrix. {ECO:0000269|PubMed:8670886}. MNXM236 none "Subunit of heterodimeric peroxisomal ABC transport complex, with Pxa2p; required for import of long-chain fatty acids into peroxisomes; similar to human adrenoleukodystrophy transporters ABCD1and ABCD2, and ALD-related proteins; mutations in ABCD1 cause X-linked adrenoleukodystrophy (X-ALD), a peroxisomal disorder; human ABCD1 and ABCD2 can each partially complement yeast pxa1 pxa2 double null mutant" NA Subunit of heterodimeric peroxisomal ABC transport complex, with Pxa2p NA Peroxisomal long-chain fatty acid import protein 2 (Peroxisomal ABC transporter 1) 5 out of 5 NA "PXA1, LPI1, PAL1, PAT2, SSH2; ATP-binding cassette long-chain fatty acid transporter PXA1" NA PeroXisomal ABC-transporter "Translocation of tetracosahexaenoyl-CoA to peroxisomes;Translocation of tetracosapentaenoyl-CoA to peroxisomes;ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix;ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix;ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix;Peroxisomal uptake of very long-chain fatty acyl CoA;ABCD4 may transport Cbl from lysosomal lumen to cytosol" 3.A.1.203.6 "Peroxisomal long-chain fatty acid import protein 1 (Peroxisomal ABC transporter 2) - Saccharomyces cerevisiae (Baker's yeast).;Peroxisomal long-chain fatty acid import protein 2 OS=Saccharomyces cerevisiae GN=PXA1 PE=1 SV=2" TRUE +YKL120W r_1574 2-isopropylmalate[c] <=> 2-isopropylmalate[m] Transports oxaloacetate and sulfate. MNXM164143 none "Mitochondrial inner membrane transporter; transports oxaloacetate, sulfate, thiosulfate, and isopropylmalate; member of the mitochondrial carrier family" NA Mitochondrial inner membrane transporter NA Mitochondrial oxaloacetate transport protein (Mitochondrial carrier protein PMT) 5 out of 5 NA "OAC1; Oac1p" NA OxaloAcetate Carrier NA 2.A.29.15.1 MITOCHONDRIAL CARRIER PROTEIN PMT - Saccharomyces cerevisiae (Baker's yeast). FALSE +YPR011C r_1642 adenosine 3',5'-bismonophosphate[c] <=> adenosine 3',5'-bismonophosphate[m] NA MNXM45 none "Mitochondrial transporter; major substrates are adenosine 5'-phosphosulfate (APS) and 3'-phospho-adenosine 5'-phosphosulfate (PAPS); member of the mitochondrial carrier family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" NA Mitochondrial transporter NA Uncharacterized mitochondrial carrier YPR011C 3 out of 5 NA hypothetical protein NA YPR011C NA 2.A.29.23.9 Uncharacterized mitochondrial carrier YPR011C OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=YPR011C PE=1 SV=1 FALSE +YBR147W r_1657 H+[c] + L-arginine[c] => H+[m] + L-arginine[m] May function as an amino acid transporter mediating the export of cationic amino acids from the vacuole. Required for optimal growth in synthetic medium. {ECO:0000269|PubMed:17986253, ECO:0000269|PubMed:23169667}. MNXM70 h+ "Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; positive regulation by Lys14p suggests that lysine may be the primary substrate; member of the PQ-loop family, with seven transmembrane domains; similar to mammalian PQLC2 vacuolar transporter; RTC2 has a paralog, YPQ1, that arose from the whole genome duplication" NA Putative vacuolar membrane transporter for cationic amino acids NA Probable vacuolar amino acid transporter YPQ3 (PQ-loop repeat-containing protein 3) (Protein RTC2) (Restriction of telomere capping protein 2) 4 out of 5 NA "RTC2, RRT11, YPQ3; cationic amino acid transporter" NA Restriction of Telomere Capping PQLC2 transports L-Arg,L-His,L-Lys from lysosomal lumen to cytosol 2.A.43.2.7 Protein RTC2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RTC2 PE=1 SV=1 FALSE +YDR508C r_1658 L-asparagine[c] => L-asparagine[m] High affinity transport of glutamine. Also transport Leu, Ser, Thr, Cys, Met and Asn. {ECO:0000269|PubMed:10467005, ECO:0000269|PubMed:10654085, ECO:0000269|PubMed:8660458}. MNXM147 none "High-affinity glutamine permease; also transports Leu, Ser, Thr, Cys, Met and Asn; expression is fully dependent on Grr1p and modulated by the Ssy1p-Ptr3p-Ssy5p (SPS) sensor of extracellular amino acids; GNP1 has a paralog, AGP1, that arose from the whole genome duplication" NA High-affinity glutamine permease NA High-affinity glutamine permease 4 out of 5 NA "GNP1; glutamine permease GNP1" NA GlutamiNe Permease NA 2.A.3.10.5 High-affinity glutamine permease - Saccharomyces cerevisiae (Baker's yeast). FALSE +YGL077C r_1684 choline[ce] <=> choline[c] Sole choline transporter in yeast. MNXM90 none "Plasma membrane transporter for choline, ethanolamine, and carnitine; involved in the uptake of nitrogen mustard and the uptake of glycine betaine during hypersaline stress; co-regulated with phospholipid biosynthetic genes and negatively regulated by choline and myo-inositol" NA Plasma membrane transporter for choline, ethanolamine, and carnitine NA Choline transport protein 5 out of 5 NA "HNM1, CTR1; Hnm1p" NA Hyper-resistance to Nitrogen Mustard NA 2.A.3.4.1 Choline transport protein - Saccharomyces cerevisiae (Baker's yeast). FALSE +YOR161C r_1684 choline[ce] <=> choline[c] Probably involved in transport through the plasma membrane. {ECO:0000250}. MNXM90 none "Protein of unknown function; has similarity to Torpedo californica tCTL1p, which is postulated to be a choline transporter, neither null mutation nor overexpression affects choline transport" NA Protein of unknown function NA Protein PNS1 (pH nine-sensitive protein 1) 2 out of 5 NA "PNS1; Pns1p" NA pH Nine Sensitive "Cho transports from the extracellular space to the cytosol;Cho transports from the extracellular space to the cytosol;Cho transports from the extracellular space to the cytosol;Cho transports from the extracellular space to the cytosol;Cho transports from the extracellular space to the cytosol;SLC44A1 transports Cho from cytosol to mitochondrial matrix;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins" 2.A.92.1.8 Protein PNS1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PNS1 PE=1 SV=1 FALSE +YDR342C r_1707 D-arabinose[e] <=> D-arabinose[c] High-affinity glucose transporter. MNXM48397 none "High-affinity glucose transporter; member of the major facilitator superfamily, nearly identical to Hxt6p, expressed at high basal levels relative to other HXTs, expression repressed by high glucose levels; HXT7 has a paralog, HXT4, that arose from the whole genome duplication" NA High-affinity glucose transporter NA High-affinity hexose transporter HXT7 5 out of 5 NA "HXT7; hexose transporter HXT7" NA HeXose Transporter NA 2.A.1.1.31 High-affinity hexose transporter HXT6 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HXT7 PE=1 SV=1 FALSE +YHR092C r_1707 D-arabinose[e] <=> D-arabinose[c] Low-affinity glucose transporter. Can also transport xylose. {ECO:0000269|PubMed:17180689}. MNXM48397 none "High-affinity glucose transporter; member of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose; HXT4 has a paralog, HXT7, that arose from the whole genome duplication" NA High-affinity glucose transporter NA Low-affinity glucose transporter HXT4 (Low-affinity glucose transporter LGT1) 5 out of 5 NA "HXT4, LGT1, RAG1; hexose transporter HXT4" NA HeXose Transporter NA 2.A.1.1.30 Low-affinity glucose transporter HXT4 (Low-affinity glucose transporter LGT1) - Saccharomyces cerevisiae (Baker's yeast). FALSE +YDL245C r_1717 D-glucitol[e] <=> D-glucitol[c] Probable glucose transporter. MNXM469 none "Putative transmembrane polyol transporter; supports growth on and uptake of mannitol, sorbitol and xylitol with moderate affinity when overexpressed in a strain deleted for hexose family members; minor hexose transport activity when overexpressed in a similar strain; similarity to hexose transporters; expression is induced by low levels of glucose and repressed by high levels of glucose" NA Putative transmembrane polyol transporter NA Hexose transporter HXT15 5 out of 5 NA "HXT15, HLT2; hexose transporter HXT15" NA HeXose Transporter NA 2.A.1.1.107 Hexose transporter HXT15 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HXT15 PE=1 SV=1 FALSE +YEL069C r_1717 D-glucitol[e] <=> D-glucitol[c] Probable glucose transporter. MNXM469 none "Putative transmembrane polyol transporter; supports growth on and uptake of mannitol and sorbitol with moderate affinity when overexpressed in a strain deleted for hexose family members; minor hexose transport activity when overexpressed in a similar strain; induced by non-fermentable carbon sources; induced in low glucose, repressed in high glucose; HXT13 has a paralog, HXT17, that arose from a segmental duplication" NA Putative transmembrane polyol transporter NA Hexose transporter HXT13 4 out of 5 NA "HXT13, HLT1; hexose transporter HXT13" NA HeXose Transporter NA 2.A.1.1.110 Hexose transporter HXT13 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HXT13 PE=1 SV=1 FALSE +YJR158W r_1717 D-glucitol[e] <=> D-glucitol[c] Probable glucose transporter. MNXM469 none "Putative transmembrane polyol transporter; supports growth on and uptake of sorbitol with moderate affinity and mannitol with lower affinity when overexpressed in a strain deleted for hexose family members; minor hexose transport activity when overexpressed in a similar strain; similarity to hexose transporters; expression is repressed by high levels of glucose" NA Putative transmembrane polyol transporter NA Hexose transporter HXT16 4 out of 5 NA "HXT16, HLT3; hexose transporter HXT16" NA HeXose Transporter NA NA NA FALSE +YNR072W r_1717 D-glucitol[e] <=> D-glucitol[c] Probable glucose transporter. MNXM469 none "Putative transmembrane polyol transporter; supports growth on and uptake of mannitol and sorbitol with moderate affinity when overexpressed in a strain deleted for hexose family members; minor hexose transport activity when overexpressed in a similar strain; induced by raffinose and galactose at pH 7.7 versus pH 4.7, repressed by high levels of glucose; HXT17 has a paralog, HXT13, that arose from a segmental duplication" NA Putative transmembrane polyol transporter NA Hexose transporter HXT17 4 out of 5 NA "HXT17, HLT4; hexose transporter HXT17" NA HeXose Transporter NA NA NA FALSE +YHR092C r_1719 D-xylose[e] <=> D-xylose[c] Low-affinity glucose transporter. Can also transport xylose. {ECO:0000269|PubMed:17180689}. MNXM90941 none "High-affinity glucose transporter; member of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose; HXT4 has a paralog, HXT7, that arose from the whole genome duplication" NA High-affinity glucose transporter NA Low-affinity glucose transporter HXT4 (Low-affinity glucose transporter LGT1) 5 out of 5 NA "HXT4, LGT1, RAG1; hexose transporter HXT4" NA HeXose Transporter NA 2.A.1.1.30 Low-affinity glucose transporter HXT4 (Low-affinity glucose transporter LGT1) - Saccharomyces cerevisiae (Baker's yeast). FALSE +YBL042C r_1735 2'-deoxyuridine[e] => 2'-deoxyuridine[c] High-affinity transport of uridine. MNXM492 none "High affinity uridine permease, localizes to the plasma membrane; also mediates low but significant transport of the cytotoxic nucleoside analog 5-fluorouridine; not involved in uracil transport; relative distribution to the vacuole increases upon DNA replication stress" NA High affinity uridine permease, localizes to the plasma membrane NA Uridine permease 4 out of 5 NA "FUI1; uridine permease" NA 5-FlUorourIdine resistance NA 2.A.39.3.3 URIDINE PERMEASE - Saccharomyces cerevisiae (Baker's yeast). FALSE +YIL013C r_1760 ergosterol[c] <=> ergosterol[ce] Transporter involved in the uptake of sterol. {ECO:0000269|PubMed:12077145}. MNXM922 none "ATP-binding cassette (ABC) transporter; multidrug transporter involved in multiple drug resistance; mediates sterol uptake when sterol biosynthesis is compromised; regulated by Pdr1p; required for anaerobic growth; PDR11 has a paralog, AUS1, that arose from the whole genome duplication" NA ATP-binding cassette (ABC) transporter NA ATP-dependent permease PDR11 4 out of 5 NA "PDR11; ATP-binding cassette multidrug transporter PDR11" NA Pleiotropic Drug Resistance NA 3.A.1.205.8 ATP-dependent permease PDR11 - Saccharomyces cerevisiae (Baker's yeast). FALSE +YOR011W r_1760 ergosterol[c] <=> ergosterol[ce] Transporter involved in the uptake of sterol. {ECO:0000269|PubMed:12077145}. MNXM922 none "Plasma membrane sterol transporter of the ATP-binding cassette family; required, along with Pdr11p, for uptake of exogenous sterols and their incorporation into the plasma membrane; activity is stimulated by phosphatidylserine; sterol uptake is required for anaerobic growth because sterol biosynthesis requires oxygen; AUS1 has a paralog, PDR11, that arose from the whole genome duplication" NA Plasma membrane sterol transporter of the ATP-binding cassette family NA ATP-dependent permease AUS1 3 out of 5 NA "AUS1; ATP-binding cassette sterol transporter AUS1" NA ABC protein involved in Uptake of Sterols NA 3.A.1.205.15 ATP-dependent permease AUS1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=AUS1 PE=1 SV=1 FALSE +YKL188C r_1771 laurate[c] <=> laurate[p] Involved in the import of activated long-chain fatty acids from the cytosol to the peroxisomal matrix. {ECO:0000269|PubMed:8670886}. MNXM402 none "Subunit of heterodimeric peroxisomal ABC transport complex, with Pxa1p; required for import of long-chain fatty acids into peroxisomes; similar to human adrenoleukodystrophy transportesr ABCD1 and ABCD2, and ALD-related proteins; mutations in ABCD1 cause X-linked adrenoleukodystrophy (X-ALD), a peroxisomal disorder; human ABCD1 and ABCD2 can each partially complement yeast pxa1 pxa2 double null mutant" NA Subunit of heterodimeric peroxisomal ABC transport complex, with Pxa1p NA Peroxisomal long-chain fatty acid import protein 1 (Peroxisomal ABC transporter 2) 5 out of 5 NA "PXA2, PAT1; ATP-binding cassette long-chain fatty acid transporter PXA2" NA PeroXisomal ABC-transporter NA 3.A.1.203.2 Peroxisomal long-chain fatty acid import protein 1 (Peroxisomal ABC transporter 2) - Saccharomyces cerevisiae (Baker's yeast). TRUE +YPL147W r_1771 laurate[c] <=> laurate[p] Involved in the import of activated long-chain fatty acids from the cytosol to the peroxisomal matrix. {ECO:0000269|PubMed:8670886}. MNXM402 none "Subunit of heterodimeric peroxisomal ABC transport complex, with Pxa2p; required for import of long-chain fatty acids into peroxisomes; similar to human adrenoleukodystrophy transporters ABCD1and ABCD2, and ALD-related proteins; mutations in ABCD1 cause X-linked adrenoleukodystrophy (X-ALD), a peroxisomal disorder; human ABCD1 and ABCD2 can each partially complement yeast pxa1 pxa2 double null mutant" NA Subunit of heterodimeric peroxisomal ABC transport complex, with Pxa2p NA Peroxisomal long-chain fatty acid import protein 2 (Peroxisomal ABC transporter 1) 5 out of 5 NA "PXA1, LPI1, PAL1, PAT2, SSH2; ATP-binding cassette long-chain fatty acid transporter PXA1" NA PeroXisomal ABC-transporter "Translocation of tetracosahexaenoyl-CoA to peroxisomes;Translocation of tetracosapentaenoyl-CoA to peroxisomes;ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix;ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix;ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix;Peroxisomal uptake of very long-chain fatty acyl CoA;ABCD4 may transport Cbl from lysosomal lumen to cytosol" 3.A.1.203.6 "Peroxisomal long-chain fatty acid import protein 1 (Peroxisomal ABC transporter 2) - Saccharomyces cerevisiae (Baker's yeast).;Peroxisomal long-chain fatty acid import protein 2 OS=Saccharomyces cerevisiae GN=PXA1 PE=1 SV=2" TRUE +YKL188C r_1772 myristate[c] <=> myristate[p] Involved in the import of activated long-chain fatty acids from the cytosol to the peroxisomal matrix. {ECO:0000269|PubMed:8670886}. MNXM314 none "Subunit of heterodimeric peroxisomal ABC transport complex, with Pxa1p; required for import of long-chain fatty acids into peroxisomes; similar to human adrenoleukodystrophy transportesr ABCD1 and ABCD2, and ALD-related proteins; mutations in ABCD1 cause X-linked adrenoleukodystrophy (X-ALD), a peroxisomal disorder; human ABCD1 and ABCD2 can each partially complement yeast pxa1 pxa2 double null mutant" NA Subunit of heterodimeric peroxisomal ABC transport complex, with Pxa1p NA Peroxisomal long-chain fatty acid import protein 1 (Peroxisomal ABC transporter 2) 5 out of 5 NA "PXA2, PAT1; ATP-binding cassette long-chain fatty acid transporter PXA2" NA PeroXisomal ABC-transporter NA 3.A.1.203.2 Peroxisomal long-chain fatty acid import protein 1 (Peroxisomal ABC transporter 2) - Saccharomyces cerevisiae (Baker's yeast). TRUE +YPL147W r_1772 myristate[c] <=> myristate[p] Involved in the import of activated long-chain fatty acids from the cytosol to the peroxisomal matrix. {ECO:0000269|PubMed:8670886}. MNXM314 none "Subunit of heterodimeric peroxisomal ABC transport complex, with Pxa2p; required for import of long-chain fatty acids into peroxisomes; similar to human adrenoleukodystrophy transporters ABCD1and ABCD2, and ALD-related proteins; mutations in ABCD1 cause X-linked adrenoleukodystrophy (X-ALD), a peroxisomal disorder; human ABCD1 and ABCD2 can each partially complement yeast pxa1 pxa2 double null mutant" NA Subunit of heterodimeric peroxisomal ABC transport complex, with Pxa2p NA Peroxisomal long-chain fatty acid import protein 2 (Peroxisomal ABC transporter 1) 5 out of 5 NA "PXA1, LPI1, PAL1, PAT2, SSH2; ATP-binding cassette long-chain fatty acid transporter PXA1" NA PeroXisomal ABC-transporter "Translocation of tetracosahexaenoyl-CoA to peroxisomes;Translocation of tetracosapentaenoyl-CoA to peroxisomes;ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix;ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix;ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix;Peroxisomal uptake of very long-chain fatty acyl CoA;ABCD4 may transport Cbl from lysosomal lumen to cytosol" 3.A.1.203.6 "Peroxisomal long-chain fatty acid import protein 1 (Peroxisomal ABC transporter 2) - Saccharomyces cerevisiae (Baker's yeast).;Peroxisomal long-chain fatty acid import protein 2 OS=Saccharomyces cerevisiae GN=PXA1 PE=1 SV=2" TRUE +YKL188C r_1774 palmitate[c] <=> palmitate[p] Involved in the import of activated long-chain fatty acids from the cytosol to the peroxisomal matrix. {ECO:0000269|PubMed:8670886}. MNXM108 none "Subunit of heterodimeric peroxisomal ABC transport complex, with Pxa1p; required for import of long-chain fatty acids into peroxisomes; similar to human adrenoleukodystrophy transportesr ABCD1 and ABCD2, and ALD-related proteins; mutations in ABCD1 cause X-linked adrenoleukodystrophy (X-ALD), a peroxisomal disorder; human ABCD1 and ABCD2 can each partially complement yeast pxa1 pxa2 double null mutant" NA Subunit of heterodimeric peroxisomal ABC transport complex, with Pxa1p NA Peroxisomal long-chain fatty acid import protein 1 (Peroxisomal ABC transporter 2) 5 out of 5 NA "PXA2, PAT1; ATP-binding cassette long-chain fatty acid transporter PXA2" NA PeroXisomal ABC-transporter NA 3.A.1.203.2 Peroxisomal long-chain fatty acid import protein 1 (Peroxisomal ABC transporter 2) - Saccharomyces cerevisiae (Baker's yeast). TRUE +YPL147W r_1774 palmitate[c] <=> palmitate[p] Involved in the import of activated long-chain fatty acids from the cytosol to the peroxisomal matrix. {ECO:0000269|PubMed:8670886}. MNXM108 none "Subunit of heterodimeric peroxisomal ABC transport complex, with Pxa2p; required for import of long-chain fatty acids into peroxisomes; similar to human adrenoleukodystrophy transporters ABCD1and ABCD2, and ALD-related proteins; mutations in ABCD1 cause X-linked adrenoleukodystrophy (X-ALD), a peroxisomal disorder; human ABCD1 and ABCD2 can each partially complement yeast pxa1 pxa2 double null mutant" NA Subunit of heterodimeric peroxisomal ABC transport complex, with Pxa2p NA Peroxisomal long-chain fatty acid import protein 2 (Peroxisomal ABC transporter 1) 5 out of 5 NA "PXA1, LPI1, PAL1, PAT2, SSH2; ATP-binding cassette long-chain fatty acid transporter PXA1" NA PeroXisomal ABC-transporter "Translocation of tetracosahexaenoyl-CoA to peroxisomes;Translocation of tetracosapentaenoyl-CoA to peroxisomes;ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix;ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix;ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix;Peroxisomal uptake of very long-chain fatty acyl CoA;ABCD4 may transport Cbl from lysosomal lumen to cytosol" 3.A.1.203.6 "Peroxisomal long-chain fatty acid import protein 1 (Peroxisomal ABC transporter 2) - Saccharomyces cerevisiae (Baker's yeast).;Peroxisomal long-chain fatty acid import protein 2 OS=Saccharomyces cerevisiae GN=PXA1 PE=1 SV=2" TRUE +YNL065W r_1795 formate[e] <=> formate[c] Probable transporter that confers resistance to short-chain monocarboxylic acids and quinidine. {ECO:0000269|PubMed:11922628}. MNXM39 none "Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; confers resistance to short-chain monocarboxylic acids and quinidine; involved in the excretion of excess amino acids; AQR1 has a paralog, QDR1, that arose from the whole genome duplication; relocalizes from plasma membrane to cytoplasm upon DNA replication stress" NA Plasma membrane transporter of the major facilitator superfamily NA Probable transporter AQR1 4 out of 5 NA "AQR1; Aqr1p" NA Acids Quinidine Resistance NA 2.A.1.2.36 Probable transporter AQR1 - Saccharomyces cerevisiae (Baker's yeast). FALSE +YGL225W r_1803 GDP-alpha-D-mannose[c] <=> GDP-alpha-D-mannose[g] Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen. Defective copy causes severe glycosylation defect and abnormal retention of soluble endoplasmic reticulum proteins. Involved in vanadate sensitivity. {ECO:0000269|PubMed:10570930, ECO:0000269|PubMed:11067855, ECO:0000269|PubMed:12478588, ECO:0000269|PubMed:15494368, ECO:0000269|PubMed:2014241, ECO:0000269|PubMed:2137555, ECO:0000269|PubMed:7672592, ECO:0000269|PubMed:7877969, ECO:0000269|PubMed:8632002, ECO:0000269|PubMed:9184829, ECO:0000269|PubMed:9335583, ECO:0000269|PubMed:9395539}. MNXM82 none "Golgi GDP-mannose transporter; regulates Golgi function and glycosylation in Golgi; VRG4 has a paralog, HVG1, that arose from the whole genome duplication" NA Golgi GDP-mannose transporter NA GDP-mannose transporter 1 (GMT 1) (Low dye-binding protein 3) (Morphogenesis checkpoint-dependent protein 3) (Vanadate resistance glycosylation protein 4) 5 out of 5 NA "VRG4, GOG5, LDB3, VAN2, VIG4; GDP-mannose transporter" NA Vandate Resistance Glycosylation NA 2.A.7.13.1 Vanadate resistance protein GOG5/VRG4/VAN2 - Saccharomyces cerevisiae (Baker's yeast). FALSE +YPR058W r_1811 L-glycine[c] <=> L-glycine[m] NA MNXM29 none "Secondary mitochondrial inner membrane glycine transporter; required with HEM25 for the transport of glycine into mitochondria for the initiation of heme biosynthesis; proposed role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; localizes to the vacuole in response to H2O2; YMC1 has a paralog, YMC2, that arose from the whole genome duplication" NA Secondary mitochondrial inner membrane glycine transporter NA Carrier protein YMC1, mitochondrial 3 out of 5 NA "YMC1; organic acid transporter" NA Yeast Mitochondrial Carrier NA 2.A.29.8.12 Carrier protein YMC1, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=YMC1 PE=1 SV=2 FALSE +YNL065W r_1816 glyoxylate[c] <=> glyoxylate[e] Probable transporter that confers resistance to short-chain monocarboxylic acids and quinidine. {ECO:0000269|PubMed:11922628}. MNXM69 none "Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; confers resistance to short-chain monocarboxylic acids and quinidine; involved in the excretion of excess amino acids; AQR1 has a paralog, QDR1, that arose from the whole genome duplication; relocalizes from plasma membrane to cytoplasm upon DNA replication stress" NA Plasma membrane transporter of the major facilitator superfamily NA Probable transporter AQR1 4 out of 5 NA "AQR1; Aqr1p" NA Acids Quinidine Resistance NA 2.A.1.2.36 Probable transporter AQR1 - Saccharomyces cerevisiae (Baker's yeast). FALSE +YBR147W r_1837 L-histidine[c] => L-histidine[m] May function as an amino acid transporter mediating the export of cationic amino acids from the vacuole. Required for optimal growth in synthetic medium. {ECO:0000269|PubMed:17986253, ECO:0000269|PubMed:23169667}. MNXM134 none "Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; positive regulation by Lys14p suggests that lysine may be the primary substrate; member of the PQ-loop family, with seven transmembrane domains; similar to mammalian PQLC2 vacuolar transporter; RTC2 has a paralog, YPQ1, that arose from the whole genome duplication" NA Putative vacuolar membrane transporter for cationic amino acids NA Probable vacuolar amino acid transporter YPQ3 (PQ-loop repeat-containing protein 3) (Protein RTC2) (Restriction of telomere capping protein 2) 4 out of 5 NA "RTC2, RRT11, YPQ3; cationic amino acid transporter" NA Restriction of Telomere Capping PQLC2 transports L-Arg,L-His,L-Lys from lysosomal lumen to cytosol 2.A.43.2.7 Protein RTC2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RTC2 PE=1 SV=1 FALSE +YDR342C r_1877 L-arabinose[e] <=> L-arabinose[c] High-affinity glucose transporter. MNXM461 none "High-affinity glucose transporter; member of the major facilitator superfamily, nearly identical to Hxt6p, expressed at high basal levels relative to other HXTs, expression repressed by high glucose levels; HXT7 has a paralog, HXT4, that arose from the whole genome duplication" NA High-affinity glucose transporter NA High-affinity hexose transporter HXT7 5 out of 5 NA "HXT7; hexose transporter HXT7" NA HeXose Transporter NA 2.A.1.1.31 High-affinity hexose transporter HXT6 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HXT7 PE=1 SV=1 FALSE +YHR092C r_1877 L-arabinose[e] <=> L-arabinose[c] Low-affinity glucose transporter. Can also transport xylose. {ECO:0000269|PubMed:17180689}. MNXM461 none "High-affinity glucose transporter; member of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose; HXT4 has a paralog, HXT7, that arose from the whole genome duplication" NA High-affinity glucose transporter NA Low-affinity glucose transporter HXT4 (Low-affinity glucose transporter LGT1) 5 out of 5 NA "HXT4, LGT1, RAG1; hexose transporter HXT4" NA HeXose Transporter NA 2.A.1.1.30 Low-affinity glucose transporter HXT4 (Low-affinity glucose transporter LGT1) - Saccharomyces cerevisiae (Baker's yeast). FALSE +YOR100C r_1882 (R)-carnitine[m] => (R)-carnitine[c] Transports carnitine, acetylcarnitine, propionylcarnitine and to a much lower extent medium- and long-chain acylcarnitines. {ECO:0000269|PubMed:10545096, ECO:0000269|PubMed:10622748}. MNXM173 none "Mitochondrial inner membrane carnitine transporter; required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation; human homolog SLC25A20 complements yeast null mutant" NA Mitochondrial inner membrane carnitine transporter NA Mitochondrial carnitine carrier 3 out of 5 NA "CRC1; carnitine:acyl carnitine antiporter" NA CaRnitine Carrier "Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane;SLC25A29 transports basic amino acids from cytosol to mitochondrial matrix" 2.A.29.8.4 Mitochondrial carnitine carrier - Saccharomyces cerevisiae (Baker's yeast). FALSE +YKR039W r_1907 L-serine[c] <=> L-serine[er] General amino-acid permease involved in the uptake of all the naturally occurring L-amino-acids, related compounds such as ornithine and citrulline, some D-amino acids, toxic amino acid analogs such as azetidine-2-carboxylate, and the polyamines putrescine and spermidine (PubMed:5474888, PubMed:10467005, PubMed:10373490, PubMed:10953083, PubMed:14968425, PubMed:15707981). Senses its transport substrates to set an appropriate level of transporter activity at the cell surface (PubMed:21471002). Required for FLO11 expression and invasive growth (PubMed:22844449). {ECO:0000269|PubMed:10373490, ECO:0000269|PubMed:10467005, ECO:0000269|PubMed:10953083, ECO:0000269|PubMed:14968425, ECO:0000269|PubMed:15707981, ECO:0000269|PubMed:21471002, ECO:0000269|PubMed:22844449, ECO:0000269|PubMed:5474888}. MNXM53 none "General amino acid permease; Gap1p senses the presence of amino acid substrates to regulate localization to the plasma membrane when needed; essential for invasive growth" NA General amino acid permease NA General amino-acid permease GAP1 5 out of 5 NA "GAP1; amino acid permease GAP1" NA General Amino acid Permease NA 2.A.3.10.2 General amino-acid permease GAP1 - Saccharomyces cerevisiae (Baker's yeast). FALSE +YDL245C r_1908 L-glucitol[e] <=> L-glucitol[c] Probable glucose transporter. MNXM4638 none "Putative transmembrane polyol transporter; supports growth on and uptake of mannitol, sorbitol and xylitol with moderate affinity when overexpressed in a strain deleted for hexose family members; minor hexose transport activity when overexpressed in a similar strain; similarity to hexose transporters; expression is induced by low levels of glucose and repressed by high levels of glucose" NA Putative transmembrane polyol transporter NA Hexose transporter HXT15 5 out of 5 NA "HXT15, HLT2; hexose transporter HXT15" NA HeXose Transporter NA 2.A.1.1.107 Hexose transporter HXT15 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HXT15 PE=1 SV=1 FALSE +YEL069C r_1908 L-glucitol[e] <=> L-glucitol[c] Probable glucose transporter. MNXM4638 none "Putative transmembrane polyol transporter; supports growth on and uptake of mannitol and sorbitol with moderate affinity when overexpressed in a strain deleted for hexose family members; minor hexose transport activity when overexpressed in a similar strain; induced by non-fermentable carbon sources; induced in low glucose, repressed in high glucose; HXT13 has a paralog, HXT17, that arose from a segmental duplication" NA Putative transmembrane polyol transporter NA Hexose transporter HXT13 4 out of 5 NA "HXT13, HLT1; hexose transporter HXT13" NA HeXose Transporter NA 2.A.1.1.110 Hexose transporter HXT13 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HXT13 PE=1 SV=1 FALSE +YJR158W r_1908 L-glucitol[e] <=> L-glucitol[c] Probable glucose transporter. MNXM4638 none "Putative transmembrane polyol transporter; supports growth on and uptake of sorbitol with moderate affinity and mannitol with lower affinity when overexpressed in a strain deleted for hexose family members; minor hexose transport activity when overexpressed in a similar strain; similarity to hexose transporters; expression is repressed by high levels of glucose" NA Putative transmembrane polyol transporter NA Hexose transporter HXT16 4 out of 5 NA "HXT16, HLT3; hexose transporter HXT16" NA HeXose Transporter NA NA NA FALSE +YNR072W r_1908 L-glucitol[e] <=> L-glucitol[c] Probable glucose transporter. MNXM4638 none "Putative transmembrane polyol transporter; supports growth on and uptake of mannitol and sorbitol with moderate affinity when overexpressed in a strain deleted for hexose family members; minor hexose transport activity when overexpressed in a similar strain; induced by raffinose and galactose at pH 7.7 versus pH 4.7, repressed by high levels of glucose; HXT17 has a paralog, HXT13, that arose from a segmental duplication" NA Putative transmembrane polyol transporter NA Hexose transporter HXT17 4 out of 5 NA "HXT17, HLT4; hexose transporter HXT17" NA HeXose Transporter NA NA NA FALSE +YDL245C r_1910 L-sorbose[e] <=> L-sorbose[c] Probable glucose transporter. MNXM588 none "Putative transmembrane polyol transporter; supports growth on and uptake of mannitol, sorbitol and xylitol with moderate affinity when overexpressed in a strain deleted for hexose family members; minor hexose transport activity when overexpressed in a similar strain; similarity to hexose transporters; expression is induced by low levels of glucose and repressed by high levels of glucose" NA Putative transmembrane polyol transporter NA Hexose transporter HXT15 5 out of 5 NA "HXT15, HLT2; hexose transporter HXT15" NA HeXose Transporter NA 2.A.1.1.107 Hexose transporter HXT15 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HXT15 PE=1 SV=1 FALSE +YDR342C r_1910 L-sorbose[e] <=> L-sorbose[c] High-affinity glucose transporter. MNXM588 none "High-affinity glucose transporter; member of the major facilitator superfamily, nearly identical to Hxt6p, expressed at high basal levels relative to other HXTs, expression repressed by high glucose levels; HXT7 has a paralog, HXT4, that arose from the whole genome duplication" NA High-affinity glucose transporter NA High-affinity hexose transporter HXT7 5 out of 5 NA "HXT7; hexose transporter HXT7" NA HeXose Transporter NA 2.A.1.1.31 High-affinity hexose transporter HXT6 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HXT7 PE=1 SV=1 FALSE +YDR343C r_1910 L-sorbose[e] <=> L-sorbose[c] High-affinity glucose transporter. MNXM588 none "High-affinity glucose transporter; member of the major facilitator superfamily, nearly identical to Hxt7p, expressed at high basal levels relative to other HXTs, repression of expression by high glucose requires SNF3; HXT6 has a paralog, HXT1, that arose from the whole genome duplication" NA High-affinity glucose transporter NA High-affinity hexose transporter HXT6 4 out of 5 NA "HXT6; hexose transporter HXT6" NA HeXose Transporter NA NA NA FALSE +YDR345C r_1910 L-sorbose[e] <=> L-sorbose[c] Low-affinity glucose transporter. MNXM588 none "Low affinity glucose transporter of the major facilitator superfamily; expression is induced in low or high glucose conditions; HXT3 has a paralog, HXT5, that arose from the whole genome duplication" NA Low affinity glucose transporter of the major facilitator superfamily NA Low-affinity glucose transporter HXT3 5 out of 5 NA "HXT3; hexose transporter HXT3" NA HeXose Transporter NA NA NA FALSE +YEL069C r_1910 L-sorbose[e] <=> L-sorbose[c] Probable glucose transporter. MNXM588 none "Putative transmembrane polyol transporter; supports growth on and uptake of mannitol and sorbitol with moderate affinity when overexpressed in a strain deleted for hexose family members; minor hexose transport activity when overexpressed in a similar strain; induced by non-fermentable carbon sources; induced in low glucose, repressed in high glucose; HXT13 has a paralog, HXT17, that arose from a segmental duplication" NA Putative transmembrane polyol transporter NA Hexose transporter HXT13 4 out of 5 NA "HXT13, HLT1; hexose transporter HXT13" NA HeXose Transporter NA 2.A.1.1.110 Hexose transporter HXT13 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HXT13 PE=1 SV=1 FALSE +YFL011W r_1910 L-sorbose[e] <=> L-sorbose[c] Probable glucose transporter. MNXM588 none "Putative hexose transporter; expressed at low levels and expression is repressed by glucose" NA Putative hexose transporter NA Hexose transporter HXT10 4 out of 5 NA "HXT10; hexose transporter HXT10" NA HeXose Transporter NA 2.A.1.1.5 Hexose transporter HXT10 - Saccharomyces cerevisiae (Baker's yeast). FALSE +YHR092C r_1910 L-sorbose[e] <=> L-sorbose[c] Low-affinity glucose transporter. Can also transport xylose. {ECO:0000269|PubMed:17180689}. MNXM588 none "High-affinity glucose transporter; member of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose; HXT4 has a paralog, HXT7, that arose from the whole genome duplication" NA High-affinity glucose transporter NA Low-affinity glucose transporter HXT4 (Low-affinity glucose transporter LGT1) 5 out of 5 NA "HXT4, LGT1, RAG1; hexose transporter HXT4" NA HeXose Transporter NA 2.A.1.1.30 Low-affinity glucose transporter HXT4 (Low-affinity glucose transporter LGT1) - Saccharomyces cerevisiae (Baker's yeast). FALSE +YHR094C r_1910 L-sorbose[e] <=> L-sorbose[c] Low-affinity glucose transporter. HXT1 is as well involved in the transport of mannose. MNXM588 none "Low-affinity glucose transporter of the major facilitator superfamily; expression is induced by Hxk2p in the presence of glucose and repressed by Rgt1p when glucose is limiting; HXT1 has a paralog, HXT6, what arose from the whole genome duplication" NA Low-affinity glucose transporter of the major facilitator superfamily NA Low-affinity glucose transporter HXT1 5 out of 5 NA "HXT1, HOR4; hexose transporter HXT1" NA HeXose Transporter NA 2.A.1.1.108 Low-affinity glucose transporter HXT1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HXT1 PE=1 SV=1 FALSE +YHR096C r_1910 L-sorbose[e] <=> L-sorbose[c] Probable glucose transporter. MNXM588 none "Hexose transporter with moderate affinity for glucose; induced in the presence of non-fermentable carbon sources, induced by a decrease in growth rate, contains an extended N-terminal domain relative to other HXTs; HXT5 has a paralog, HXT3, that arose from the whole genome duplication" NA Hexose transporter with moderate affinity for glucose NA Probable glucose transporter HXT5 4 out of 5 NA "HXT5; hexose transporter HXT5" NA HeXose Transporter NA NA NA FALSE +YJL214W r_1910 L-sorbose[e] <=> L-sorbose[c] Probable glucose transporter. MNXM588 none "Protein of unknown function with similarity to hexose transporters; expression is induced by low levels of glucose and repressed by high levels of glucose" NA Protein of unknown function with similarity to hexose transporters NA Hexose transporter HXT8 4 out of 5 NA "HXT8; hexose transporter HXT8" NA HeXose Transporter NA NA NA FALSE +YJL219W r_1910 L-sorbose[e] <=> L-sorbose[c] Probable glucose transporter. MNXM588 none "Putative hexose transporter that is nearly identical to Hxt11p; has similarity to major facilitator superfamily (MFS) transporters, expression of HXT9 is regulated by transcription factors Pdr1p and Pdr3p" NA Putative hexose transporter that is nearly identical to Hxt11p NA Hexose transporter HXT9 4 out of 5 NA "HXT9; hexose transporter HXT9" NA HeXose Transporter NA NA NA FALSE +YJR158W r_1910 L-sorbose[e] <=> L-sorbose[c] Probable glucose transporter. MNXM588 none "Putative transmembrane polyol transporter; supports growth on and uptake of sorbitol with moderate affinity and mannitol with lower affinity when overexpressed in a strain deleted for hexose family members; minor hexose transport activity when overexpressed in a similar strain; similarity to hexose transporters; expression is repressed by high levels of glucose" NA Putative transmembrane polyol transporter NA Hexose transporter HXT16 4 out of 5 NA "HXT16, HLT3; hexose transporter HXT16" NA HeXose Transporter NA NA NA FALSE +YMR011W r_1910 L-sorbose[e] <=> L-sorbose[c] High-affinity glucose transporter. Is only indispensable for growth on low glucose-containing media, because S.cerevisiae possesses other sugar transporters. MNXM588 none "High-affinity glucose transporter of the major facilitator superfamily; expression is induced by low levels of glucose and repressed by high levels of glucose" NA High-affinity glucose transporter of the major facilitator superfamily NA High-affinity glucose transporter HXT2 4 out of 5 NA "HXT2; hexose transporter HXT2" NA HeXose Transporter NA 2.A.1.1.111 High-affinity glucose transporter HXT2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HXT2 PE=1 SV=1 FALSE +YNR072W r_1910 L-sorbose[e] <=> L-sorbose[c] Probable glucose transporter. MNXM588 none "Putative transmembrane polyol transporter; supports growth on and uptake of mannitol and sorbitol with moderate affinity when overexpressed in a strain deleted for hexose family members; minor hexose transport activity when overexpressed in a similar strain; induced by raffinose and galactose at pH 7.7 versus pH 4.7, repressed by high levels of glucose; HXT17 has a paralog, HXT13, that arose from a segmental duplication" NA Putative transmembrane polyol transporter NA Hexose transporter HXT17 4 out of 5 NA "HXT17, HLT4; hexose transporter HXT17" NA HeXose Transporter NA NA NA FALSE +YOL156W r_1910 L-sorbose[e] <=> L-sorbose[c] Probable glucose transporter. MNXM588 none "Hexose transporter; capable of transporting a broad range of substrates including: glucose, fructose, mannose and galactose; polyol transporter that supports the growth on and uptake of xylitol with low affinity when overexpressed in a strain deleted for hexose family members; nearly identical in sequence to Hxt9p; has similarity to major facilitator superfamily (MFS) transporters; involved in pleiotropic drug resistance" NA Hexose transporter NA Hexose transporter HXT11 (Low-affinity glucose transporter LGT3) 4 out of 5 NA "HXT11, LGT3; hexose transporter HXT11" NA HeXose Transporter NA 2.A.1.1.105 Hexose transporter HXT11 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HXT11 PE=1 SV=1 FALSE +YBR147W r_1919 L-lysine[c] => L-lysine[m] May function as an amino acid transporter mediating the export of cationic amino acids from the vacuole. Required for optimal growth in synthetic medium. {ECO:0000269|PubMed:17986253, ECO:0000269|PubMed:23169667}. MNXM78 none "Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; positive regulation by Lys14p suggests that lysine may be the primary substrate; member of the PQ-loop family, with seven transmembrane domains; similar to mammalian PQLC2 vacuolar transporter; RTC2 has a paralog, YPQ1, that arose from the whole genome duplication" NA Putative vacuolar membrane transporter for cationic amino acids NA Probable vacuolar amino acid transporter YPQ3 (PQ-loop repeat-containing protein 3) (Protein RTC2) (Restriction of telomere capping protein 2) 4 out of 5 NA "RTC2, RRT11, YPQ3; cationic amino acid transporter" NA Restriction of Telomere Capping PQLC2 transports L-Arg,L-His,L-Lys from lysosomal lumen to cytosol 2.A.43.2.7 Protein RTC2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RTC2 PE=1 SV=1 FALSE +YDR508C r_1935 L-methionine[m] => L-methionine[c] High affinity transport of glutamine. Also transport Leu, Ser, Thr, Cys, Met and Asn. {ECO:0000269|PubMed:10467005, ECO:0000269|PubMed:10654085, ECO:0000269|PubMed:8660458}. MNXM61 none "High-affinity glutamine permease; also transports Leu, Ser, Thr, Cys, Met and Asn; expression is fully dependent on Grr1p and modulated by the Ssy1p-Ptr3p-Ssy5p (SPS) sensor of extracellular amino acids; GNP1 has a paralog, AGP1, that arose from the whole genome duplication" NA High-affinity glutamine permease NA High-affinity glutamine permease 4 out of 5 NA "GNP1; glutamine permease GNP1" NA GlutamiNe Permease NA 2.A.3.10.5 High-affinity glutamine permease - Saccharomyces cerevisiae (Baker's yeast). FALSE +YOR100C r_1976 O-acetylcarnitine[c] => O-acetylcarnitine[m] Transports carnitine, acetylcarnitine, propionylcarnitine and to a much lower extent medium- and long-chain acylcarnitines. {ECO:0000269|PubMed:10545096, ECO:0000269|PubMed:10622748}. MNXM1028 none "Mitochondrial inner membrane carnitine transporter; required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation; human homolog SLC25A20 complements yeast null mutant" NA Mitochondrial inner membrane carnitine transporter NA Mitochondrial carnitine carrier 3 out of 5 NA "CRC1; carnitine:acyl carnitine antiporter" NA CaRnitine Carrier "Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane;SLC25A29 transports basic amino acids from cytosol to mitochondrial matrix" 2.A.29.8.4 Mitochondrial carnitine carrier - Saccharomyces cerevisiae (Baker's yeast). FALSE +YJL212C r_1990 glutathione disulfide[e] => glutathione disulfide[c] High affinity transporter for glutathione. Also transports tetra- and pentapeptides like the opioids leucine enkephalin (Tyr-Gly-Gly-Phe-Leu) and methionine enkephalin (Tyr-Gly-Gly_Phe-Met) across the cell membrane. {ECO:0000269|PubMed:10652283, ECO:0000269|PubMed:10788431}. MNXM151 none "Proton-coupled oligopeptide transporter of the plasma membrane; also transports glutathione and phytochelatin; member of the OPT family" NA Proton-coupled oligopeptide transporter of the plasma membrane NA Oligopeptide transporter 1 (High affinity glutathione transporter 1) 4 out of 5 NA "OPT1, GSH11, HGT1; oligopeptide transporter OPT1" NA OligoPeptide Transporter NA 2.A.67.1.3 HYPOTHETICAL 91.6 KDA PROTEIN IN HXT8-CRT1 INTERGENIC REGION - Saccharomyces cerevisiae (Baker's yeast). FALSE +YNR013C r_2008 phosphate[c] <=> phosphate[v] Vacuolar phosphate transporter that probably exports phosphate from the vacuolar lumen to the cytosol. {ECO:0000269|PubMed:11779791, ECO:0000269|PubMed:17804816, ECO:0000269|PubMed:20133652}. MNXM9 none "Low-affinity vacuolar phosphate transporter; exports phosphate from the vacuolar lumen to the cytosol; regulates phosphate and polyphosphate metabolism; acts upstream of Pho81p in regulation of the PHO pathway; localizes to sites of contact between the vacuole and mitochondria (vCLAMPs); deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth" NA Low-affinity vacuolar phosphate transporter NA Low-affinity phosphate transporter PHO91 5 out of 5 NA "PHO91; Pho91p" NA PHOsphate metabolism NA 2.A.47.2.2 Uncharacterized transporter YNR013C - Saccharomyces cerevisiae (Baker's yeast). FALSE +YOR306C r_2040 riboflavin[e] => riboflavin[c] Riboflavin transporter involved in riboflavin (vitamin B2) uptake. Does not act in the transport of monocarboxylic acids across the plasma membrane. {ECO:0000269|PubMed:16204239}. MNXM270 none "Plasma membrane riboflavin transporter; facilitates the uptake of vitamin B2; required for FAD-dependent processes; sequence similarity to mammalian monocarboxylate permeases, however mutants are not deficient in monocarboxylate transport" NA Plasma membrane riboflavin transporter NA Riboflavin transporter MCH5 3 out of 5 NA "MCH5; Mch5p" NA MonoCarboxylate transporter Homologue NA 2.A.1.13.4 S.cerevisiae chromosome XV reading frame ORF YOR306c - Saccharomyces cerevisiae (Baker's yeast). FALSE +YDR342C r_2041 D-ribose[e] => D-ribose[c] High-affinity glucose transporter. MNXM242 none "High-affinity glucose transporter; member of the major facilitator superfamily, nearly identical to Hxt6p, expressed at high basal levels relative to other HXTs, expression repressed by high glucose levels; HXT7 has a paralog, HXT4, that arose from the whole genome duplication" NA High-affinity glucose transporter NA High-affinity hexose transporter HXT7 5 out of 5 NA "HXT7; hexose transporter HXT7" NA HeXose Transporter NA 2.A.1.1.31 High-affinity hexose transporter HXT6 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HXT7 PE=1 SV=1 FALSE +YHR092C r_2041 D-ribose[e] => D-ribose[c] Low-affinity glucose transporter. Can also transport xylose. {ECO:0000269|PubMed:17180689}. MNXM242 none "High-affinity glucose transporter; member of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose; HXT4 has a paralog, HXT7, that arose from the whole genome duplication" NA High-affinity glucose transporter NA Low-affinity glucose transporter HXT4 (Low-affinity glucose transporter LGT1) 5 out of 5 NA "HXT4, LGT1, RAG1; hexose transporter HXT4" NA HeXose Transporter NA 2.A.1.1.30 Low-affinity glucose transporter HXT4 (Low-affinity glucose transporter LGT1) - Saccharomyces cerevisiae (Baker's yeast). FALSE +YDR508C r_2045 L-serine[c] <=> L-serine[m] High affinity transport of glutamine. Also transport Leu, Ser, Thr, Cys, Met and Asn. {ECO:0000269|PubMed:10467005, ECO:0000269|PubMed:10654085, ECO:0000269|PubMed:8660458}. MNXM53 none "High-affinity glutamine permease; also transports Leu, Ser, Thr, Cys, Met and Asn; expression is fully dependent on Grr1p and modulated by the Ssy1p-Ptr3p-Ssy5p (SPS) sensor of extracellular amino acids; GNP1 has a paralog, AGP1, that arose from the whole genome duplication" NA High-affinity glutamine permease NA High-affinity glutamine permease 4 out of 5 NA "GNP1; glutamine permease GNP1" NA GlutamiNe Permease NA 2.A.3.10.5 High-affinity glutamine permease - Saccharomyces cerevisiae (Baker's yeast). FALSE +YDR508C r_2072 L-threonine[c] => L-threonine[m] High affinity transport of glutamine. Also transport Leu, Ser, Thr, Cys, Met and Asn. {ECO:0000269|PubMed:10467005, ECO:0000269|PubMed:10654085, ECO:0000269|PubMed:8660458}. MNXM142 none "High-affinity glutamine permease; also transports Leu, Ser, Thr, Cys, Met and Asn; expression is fully dependent on Grr1p and modulated by the Ssy1p-Ptr3p-Ssy5p (SPS) sensor of extracellular amino acids; GNP1 has a paralog, AGP1, that arose from the whole genome duplication" NA High-affinity glutamine permease NA High-affinity glutamine permease 4 out of 5 NA "GNP1; glutamine permease GNP1" NA GlutamiNe Permease NA 2.A.3.10.5 High-affinity glutamine permease - Saccharomyces cerevisiae (Baker's yeast). FALSE +YLL052C r_2094 H2O[c] <=> H2O[er] Water channel required to facilitate the transport of water across membranes. Involved in freeze tolerance, osmotolerance and cell flocculation in liquid cultures (By similarity). Is non-functional in most laboratory strains. {ECO:0000250}. MNXM2 none "Water channel that mediates water transport across cell membranes; only expressed in proliferating cells; controlled by osmotic signals; may be involved in freeze tolerance; disrupted by a stop codon in many S. cerevisiae strains" NA Water channel that mediates water transport across cell membranes NA Aquaporin-like protein 2 (Truncated aquaporin-2) 4 out of 5 NA "AQY2; Aqy2p" NA AQuaporin of Yeast "AQP1 passively tranlocates carbon dioxide from the extracellular region to the cytosol;AQP1 passively translocates carbon dioxide from the cytosol to the extracellular region;Aquaporin-1 passively transports water into cell;Aquaporin-6 passively transports anions out of vesicles;Aquaporin-1 passively transports water out of cell;p-S256-Aquaporin-2 passively transports water into cell;Aquaporin-4 passively transports water out of cell;Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA);Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA);Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells" NA NA FALSE +YPR192W r_2094 H2O[c] <=> H2O[er] Water channel required to facilitate the transport of water across membranes. Involved in sporulation, freeze tolerance and osmotolerance (By similarity). Is non-functional in most laboratory strains. {ECO:0000250, ECO:0000269|PubMed:10092523, ECO:0000269|PubMed:10870101, ECO:0000269|PubMed:9765289}. MNXM2 none "Spore-specific water channel; mediates the transport of water across cell membranes, developmentally controlled; may play a role in spore maturation, probably by allowing water outflow, may be involved in freeze tolerance" NA Spore-specific water channel NA Aquaporin-1 5 out of 5 NA "AQY1; Aqy1p" NA AQuaporin of Yeast "AQP1 passively tranlocates carbon dioxide from the extracellular region to the cytosol;AQP1 passively translocates carbon dioxide from the cytosol to the extracellular region;Aquaporin-1 passively transports water into cell;Aquaporin-6 passively transports anions out of vesicles;Aquaporin-1 passively transports water out of cell;p-S256-Aquaporin-2 passively transports water into cell;Aquaporin-4 passively transports water out of cell;Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA);Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA);Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells" NA NA FALSE +YDL245C r_2105 xylitol[e] <=> xylitol[c] Probable glucose transporter. MNXM510 none "Putative transmembrane polyol transporter; supports growth on and uptake of mannitol, sorbitol and xylitol with moderate affinity when overexpressed in a strain deleted for hexose family members; minor hexose transport activity when overexpressed in a similar strain; similarity to hexose transporters; expression is induced by low levels of glucose and repressed by high levels of glucose" NA Putative transmembrane polyol transporter NA Hexose transporter HXT15 5 out of 5 NA "HXT15, HLT2; hexose transporter HXT15" NA HeXose Transporter NA 2.A.1.1.107 Hexose transporter HXT15 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HXT15 PE=1 SV=1 FALSE +YLL043W r_2105 xylitol[e] <=> xylitol[c] Channel protein for glycerol. Has a role in both glycerol influx and efflux. Plays a role in osmoregulation: under osmotic stress the channel is apparently closed to allow accumulation of glycerol in the cell under hyperosmotic conditions. MNXM510 none "Aquaglyceroporin, plasma membrane channel; involved in efflux of glycerol and xylitol, and in uptake of acetic acid, arsenite, and antimonite; key factor in maintaining redox balance by mediating passive diffusion of glycerol; phosphorylated by Hog1p MAPK under acetate stress; deletion improves xylose fermentation; regulated by Rgc1p and Ask10p, which are regulated by Hog1p phosphorylation under osmotic stress; phosphorylation by Ypk1p required to maintain an open state" NA Aquaglyceroporin, plasma membrane channel NA Glycerol uptake/efflux facilitator protein 5 out of 5 NA "FPS1; Fps1p" NA fdp1 Suppressor NA 1.A.8.5.1 GLYCEROL UPTAKE/EFFLUX FACILITATOR PROTEIN - Saccharomyces cerevisiae (Baker's yeast). FALSE +YIL013C r_2107 zymosterol[ce] <=> zymosterol[c] Transporter involved in the uptake of sterol. {ECO:0000269|PubMed:12077145}. MNXM574 none "ATP-binding cassette (ABC) transporter; multidrug transporter involved in multiple drug resistance; mediates sterol uptake when sterol biosynthesis is compromised; regulated by Pdr1p; required for anaerobic growth; PDR11 has a paralog, AUS1, that arose from the whole genome duplication" NA ATP-binding cassette (ABC) transporter NA ATP-dependent permease PDR11 4 out of 5 NA "PDR11; ATP-binding cassette multidrug transporter PDR11" NA Pleiotropic Drug Resistance NA 3.A.1.205.8 ATP-dependent permease PDR11 - Saccharomyces cerevisiae (Baker's yeast). FALSE +YOR011W r_2107 zymosterol[ce] <=> zymosterol[c] Transporter involved in the uptake of sterol. {ECO:0000269|PubMed:12077145}. MNXM574 none "Plasma membrane sterol transporter of the ATP-binding cassette family; required, along with Pdr11p, for uptake of exogenous sterols and their incorporation into the plasma membrane; activity is stimulated by phosphatidylserine; sterol uptake is required for anaerobic growth because sterol biosynthesis requires oxygen; AUS1 has a paralog, PDR11, that arose from the whole genome duplication" NA Plasma membrane sterol transporter of the ATP-binding cassette family NA ATP-dependent permease AUS1 3 out of 5 NA "AUS1; ATP-binding cassette sterol transporter AUS1" NA ABC protein involved in Uptake of Sterols NA 3.A.1.205.15 ATP-dependent permease AUS1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=AUS1 PE=1 SV=1 FALSE +YNL065W r_2190 butyrate[e] <=> butyrate[c] Probable transporter that confers resistance to short-chain monocarboxylic acids and quinidine. {ECO:0000269|PubMed:11922628}. MNXM458 none "Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; confers resistance to short-chain monocarboxylic acids and quinidine; involved in the excretion of excess amino acids; AQR1 has a paralog, QDR1, that arose from the whole genome duplication; relocalizes from plasma membrane to cytoplasm upon DNA replication stress" NA Plasma membrane transporter of the major facilitator superfamily NA Probable transporter AQR1 4 out of 5 NA "AQR1; Aqr1p" NA Acids Quinidine Resistance NA 2.A.1.2.36 Probable transporter AQR1 - Saccharomyces cerevisiae (Baker's yeast). FALSE +YNL065W r_2191 hexanoate[e] <=> hexanoate[c] Probable transporter that confers resistance to short-chain monocarboxylic acids and quinidine. {ECO:0000269|PubMed:11922628}. MNXM1653 none "Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; confers resistance to short-chain monocarboxylic acids and quinidine; involved in the excretion of excess amino acids; AQR1 has a paralog, QDR1, that arose from the whole genome duplication; relocalizes from plasma membrane to cytoplasm upon DNA replication stress" NA Plasma membrane transporter of the major facilitator superfamily NA Probable transporter AQR1 4 out of 5 NA "AQR1; Aqr1p" NA Acids Quinidine Resistance NA 2.A.1.2.36 Probable transporter AQR1 - Saccharomyces cerevisiae (Baker's yeast). FALSE +YKL188C r_2231 oleate[c] <=> oleate[p] Involved in the import of activated long-chain fatty acids from the cytosol to the peroxisomal matrix. {ECO:0000269|PubMed:8670886}. MNXM306 none "Subunit of heterodimeric peroxisomal ABC transport complex, with Pxa1p; required for import of long-chain fatty acids into peroxisomes; similar to human adrenoleukodystrophy transportesr ABCD1 and ABCD2, and ALD-related proteins; mutations in ABCD1 cause X-linked adrenoleukodystrophy (X-ALD), a peroxisomal disorder; human ABCD1 and ABCD2 can each partially complement yeast pxa1 pxa2 double null mutant" NA Subunit of heterodimeric peroxisomal ABC transport complex, with Pxa1p NA Peroxisomal long-chain fatty acid import protein 1 (Peroxisomal ABC transporter 2) 5 out of 5 NA "PXA2, PAT1; ATP-binding cassette long-chain fatty acid transporter PXA2" NA PeroXisomal ABC-transporter NA 3.A.1.203.2 Peroxisomal long-chain fatty acid import protein 1 (Peroxisomal ABC transporter 2) - Saccharomyces cerevisiae (Baker's yeast). TRUE +YPL147W r_2231 oleate[c] <=> oleate[p] Involved in the import of activated long-chain fatty acids from the cytosol to the peroxisomal matrix. {ECO:0000269|PubMed:8670886}. MNXM306 none "Subunit of heterodimeric peroxisomal ABC transport complex, with Pxa2p; required for import of long-chain fatty acids into peroxisomes; similar to human adrenoleukodystrophy transporters ABCD1and ABCD2, and ALD-related proteins; mutations in ABCD1 cause X-linked adrenoleukodystrophy (X-ALD), a peroxisomal disorder; human ABCD1 and ABCD2 can each partially complement yeast pxa1 pxa2 double null mutant" NA Subunit of heterodimeric peroxisomal ABC transport complex, with Pxa2p NA Peroxisomal long-chain fatty acid import protein 2 (Peroxisomal ABC transporter 1) 5 out of 5 NA "PXA1, LPI1, PAL1, PAT2, SSH2; ATP-binding cassette long-chain fatty acid transporter PXA1" NA PeroXisomal ABC-transporter "Translocation of tetracosahexaenoyl-CoA to peroxisomes;Translocation of tetracosapentaenoyl-CoA to peroxisomes;ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix;ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix;ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix;Peroxisomal uptake of very long-chain fatty acyl CoA;ABCD4 may transport Cbl from lysosomal lumen to cytosol" 3.A.1.203.6 "Peroxisomal long-chain fatty acid import protein 1 (Peroxisomal ABC transporter 2) - Saccharomyces cerevisiae (Baker's yeast).;Peroxisomal long-chain fatty acid import protein 2 OS=Saccharomyces cerevisiae GN=PXA1 PE=1 SV=2" TRUE +YLL052C r_3526 H2O[c] <=> H2O[erm] Water channel required to facilitate the transport of water across membranes. Involved in freeze tolerance, osmotolerance and cell flocculation in liquid cultures (By similarity). Is non-functional in most laboratory strains. {ECO:0000250}. MNXM2 none "Water channel that mediates water transport across cell membranes; only expressed in proliferating cells; controlled by osmotic signals; may be involved in freeze tolerance; disrupted by a stop codon in many S. cerevisiae strains" NA Water channel that mediates water transport across cell membranes NA Aquaporin-like protein 2 (Truncated aquaporin-2) 4 out of 5 NA "AQY2; Aqy2p" NA AQuaporin of Yeast "AQP1 passively tranlocates carbon dioxide from the extracellular region to the cytosol;AQP1 passively translocates carbon dioxide from the cytosol to the extracellular region;Aquaporin-1 passively transports water into cell;Aquaporin-6 passively transports anions out of vesicles;Aquaporin-1 passively transports water out of cell;p-S256-Aquaporin-2 passively transports water into cell;Aquaporin-4 passively transports water out of cell;Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA);Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA);Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells" NA NA FALSE +YPR192W r_3526 H2O[c] <=> H2O[erm] Water channel required to facilitate the transport of water across membranes. Involved in sporulation, freeze tolerance and osmotolerance (By similarity). Is non-functional in most laboratory strains. {ECO:0000250, ECO:0000269|PubMed:10092523, ECO:0000269|PubMed:10870101, ECO:0000269|PubMed:9765289}. MNXM2 none "Spore-specific water channel; mediates the transport of water across cell membranes, developmentally controlled; may play a role in spore maturation, probably by allowing water outflow, may be involved in freeze tolerance" NA Spore-specific water channel NA Aquaporin-1 5 out of 5 NA "AQY1; Aqy1p" NA AQuaporin of Yeast "AQP1 passively tranlocates carbon dioxide from the extracellular region to the cytosol;AQP1 passively translocates carbon dioxide from the cytosol to the extracellular region;Aquaporin-1 passively transports water into cell;Aquaporin-6 passively transports anions out of vesicles;Aquaporin-1 passively transports water out of cell;p-S256-Aquaporin-2 passively transports water into cell;Aquaporin-4 passively transports water out of cell;Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA);Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA);Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells" NA NA FALSE +YKR039W r_3545 L-serine[c] <=> L-serine[erm] General amino-acid permease involved in the uptake of all the naturally occurring L-amino-acids, related compounds such as ornithine and citrulline, some D-amino acids, toxic amino acid analogs such as azetidine-2-carboxylate, and the polyamines putrescine and spermidine (PubMed:5474888, PubMed:10467005, PubMed:10373490, PubMed:10953083, PubMed:14968425, PubMed:15707981). Senses its transport substrates to set an appropriate level of transporter activity at the cell surface (PubMed:21471002). Required for FLO11 expression and invasive growth (PubMed:22844449). {ECO:0000269|PubMed:10373490, ECO:0000269|PubMed:10467005, ECO:0000269|PubMed:10953083, ECO:0000269|PubMed:14968425, ECO:0000269|PubMed:15707981, ECO:0000269|PubMed:21471002, ECO:0000269|PubMed:22844449, ECO:0000269|PubMed:5474888}. MNXM53 none "General amino acid permease; Gap1p senses the presence of amino acid substrates to regulate localization to the plasma membrane when needed; essential for invasive growth" NA General amino acid permease NA General amino-acid permease GAP1 5 out of 5 NA "GAP1; amino acid permease GAP1" NA General Amino acid Permease NA 2.A.3.10.2 General amino-acid permease GAP1 - Saccharomyces cerevisiae (Baker's yeast). FALSE +YLL052C r_3604 H2O[c] <=> H2O[ce] Water channel required to facilitate the transport of water across membranes. Involved in freeze tolerance, osmotolerance and cell flocculation in liquid cultures (By similarity). Is non-functional in most laboratory strains. {ECO:0000250}. MNXM2 none "Water channel that mediates water transport across cell membranes; only expressed in proliferating cells; controlled by osmotic signals; may be involved in freeze tolerance; disrupted by a stop codon in many S. cerevisiae strains" NA Water channel that mediates water transport across cell membranes NA Aquaporin-like protein 2 (Truncated aquaporin-2) 4 out of 5 NA "AQY2; Aqy2p" NA AQuaporin of Yeast "AQP1 passively tranlocates carbon dioxide from the extracellular region to the cytosol;AQP1 passively translocates carbon dioxide from the cytosol to the extracellular region;Aquaporin-1 passively transports water into cell;Aquaporin-6 passively transports anions out of vesicles;Aquaporin-1 passively transports water out of cell;p-S256-Aquaporin-2 passively transports water into cell;Aquaporin-4 passively transports water out of cell;Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA);Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA);Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells" NA NA FALSE +YLL053C r_3604 H2O[c] <=> H2O[ce] NA MNXM2 none "Putative protein; in the Sigma 1278B strain background YLL053C is contiguous with AQY2 which encodes an aquaporin" NA Putative protein NA Putative uncharacterized protein YLL053C 2 out of 5 NA hypothetical protein NA YLL053C "AQP1 passively tranlocates carbon dioxide from the extracellular region to the cytosol;AQP1 passively translocates carbon dioxide from the cytosol to the extracellular region;Aquaporin-1 passively transports water into cell;Aquaporin-6 passively transports anions out of vesicles;Aquaporin-1 passively transports water out of cell;p-S256-Aquaporin-2 passively transports water into cell;Aquaporin-4 passively transports water out of cell;Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA);Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA);Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells" NA NA FALSE +YPR192W r_3604 H2O[c] <=> H2O[ce] Water channel required to facilitate the transport of water across membranes. Involved in sporulation, freeze tolerance and osmotolerance (By similarity). Is non-functional in most laboratory strains. {ECO:0000250, ECO:0000269|PubMed:10092523, ECO:0000269|PubMed:10870101, ECO:0000269|PubMed:9765289}. MNXM2 none "Spore-specific water channel; mediates the transport of water across cell membranes, developmentally controlled; may play a role in spore maturation, probably by allowing water outflow, may be involved in freeze tolerance" NA Spore-specific water channel NA Aquaporin-1 5 out of 5 NA "AQY1; Aqy1p" NA AQuaporin of Yeast "AQP1 passively tranlocates carbon dioxide from the extracellular region to the cytosol;AQP1 passively translocates carbon dioxide from the cytosol to the extracellular region;Aquaporin-1 passively transports water into cell;Aquaporin-6 passively transports anions out of vesicles;Aquaporin-1 passively transports water out of cell;p-S256-Aquaporin-2 passively transports water into cell;Aquaporin-4 passively transports water out of cell;Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA);Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA);Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water into cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells;Aquaporins passively transport water out of cells" NA NA FALSE +YCR037C r_3605 phosphate[c] <=> phosphate[ce] Involved in the uptake of inorganic phosphate. MNXM9 none "Low-affinity inorganic phosphate (Pi) transporter; acts upstream of Pho81p in regulation of the PHO pathway; expression is independent of Pi concentration and Pho4p activity; contains 12 membrane-spanning segments; PHO87 has a paralog, PHO90, that arose from the whole genome duplication" NA Low-affinity inorganic phosphate (Pi) transporter NA Inorganic phosphate transporter PHO87 4 out of 5 NA "PHO87; SPX domain-containing inorganic phosphate transporter" NA PHOsphate metabolism NA 2.A.47.2.1 INORGANIC PHOSPHATE TRANSPORTER PHO87 - Saccharomyces cerevisiae (Baker's yeast). FALSE +YJL198W r_3605 phosphate[c] <=> phosphate[ce] Low-affinity phosphate transporter involved in the control of cellular phosphate levels. {ECO:0000269|PubMed:11779791, ECO:0000269|PubMed:20133652}. MNXM9 none "Low-affinity phosphate transporter; acts upstream of Pho81p in regulation of the PHO pathway; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth; PHO90 has a paralog, PHO87, that arose from the whole genome duplication" NA Low-affinity phosphate transporter NA Low-affinity phosphate transporter PHO90 4 out of 5 NA "PHO90; SPX domain-containing inorganic phosphate transporter" NA PHOsphate metabolism NA 2.A.47.2.3 Low-affinity phosphate transporter PHO90 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PHO90 PE=1 SV=1 FALSE +YML123C r_3605 phosphate[c] <=> phosphate[ce] High-affinity transporter for external inorganic phosphate. Is not an essential protein, since a constitutive, low affinity pI transporter exists in yeast. MNXM9 none "High-affinity inorganic phosphate (Pi) transporter; also low-affinity manganese transporter; regulated by Pho4p and Spt7p; mutation confers resistance to arsenate; exit from the ER during maturation requires Pho86p; cells overexpressing Pho84p accumulate heavy metals but do not develop symptoms of metal toxicity" NA High-affinity inorganic phosphate (Pi) transporter NA Inorganic phosphate transporter PHO84 5 out of 5 NA "PHO84; phosphate transporter PHO84" NA PHOsphate metabolism NA 2.A.1.9.1 Inorganic phosphate transporter PHO84 - Saccharomyces cerevisiae (Baker's yeast). FALSE +YCR098C r_3606 sn-glycero-3-phosphocholine[ce] <=> sn-glycero-3-phosphocholine[c] Glycerophosphodiester transporter that mediates uptake of both glycerophosphoinositol (GroPIns) and glycerophosphocholine (GroPCho) as sources of the nutrients inositol and phosphate (PubMed:9691030, PubMed:12912892, PubMed:16141200). {ECO:0000269|PubMed:12912892, ECO:0000269|PubMed:16141200, ECO:0000269|PubMed:9691030}. MNXM367 none "Plasma membrane permease; mediates uptake of glycerophosphoinositol and glycerophosphocholine as sources of the nutrients inositol and phosphate; expression and transport rate are regulated by phosphate and inositol availability" NA Plasma membrane permease NA Glycerophosphoinositol transporter 1 4 out of 5 NA "GIT1; Git1p" NA GlycerophosphoInosiTol NA 2.A.1.9.7 Probable metabolite transport protein GIT1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=GIT1 PE=1 SV=1 FALSE +YCR098C r_3607 1-(sn-glycero-3-phospho)-1D-myo-inositol[ce] <=> 1-(sn-glycero-3-phospho)-1D-myo-inositol[c] Glycerophosphodiester transporter that mediates uptake of both glycerophosphoinositol (GroPIns) and glycerophosphocholine (GroPCho) as sources of the nutrients inositol and phosphate (PubMed:9691030, PubMed:12912892, PubMed:16141200). {ECO:0000269|PubMed:12912892, ECO:0000269|PubMed:16141200, ECO:0000269|PubMed:9691030}. MNXM1517 none "Plasma membrane permease; mediates uptake of glycerophosphoinositol and glycerophosphocholine as sources of the nutrients inositol and phosphate; expression and transport rate are regulated by phosphate and inositol availability" NA Plasma membrane permease NA Glycerophosphoinositol transporter 1 4 out of 5 NA "GIT1; Git1p" NA GlycerophosphoInosiTol NA 2.A.1.9.7 Probable metabolite transport protein GIT1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=GIT1 PE=1 SV=1 FALSE +YNR013C r_3649 phosphate[c] <=> phosphate[vm] Vacuolar phosphate transporter that probably exports phosphate from the vacuolar lumen to the cytosol. {ECO:0000269|PubMed:11779791, ECO:0000269|PubMed:17804816, ECO:0000269|PubMed:20133652}. MNXM9 none "Low-affinity vacuolar phosphate transporter; exports phosphate from the vacuolar lumen to the cytosol; regulates phosphate and polyphosphate metabolism; acts upstream of Pho81p in regulation of the PHO pathway; localizes to sites of contact between the vacuole and mitochondria (vCLAMPs); deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth" NA Low-affinity vacuolar phosphate transporter NA Low-affinity phosphate transporter PHO91 5 out of 5 NA "PHO91; Pho91p" NA PHOsphate metabolism NA 2.A.47.2.2 Uncharacterized transporter YNR013C - Saccharomyces cerevisiae (Baker's yeast). FALSE +YHR002W r_3680 coenzyme A[mm] <=> coenzyme A[c] Required for the accumulation of coenzyme A in the mitochondrial matrix. {ECO:0000269|PubMed:11158296}. MNXM12 none "Mitochondrial carrier protein; involved in the accumulation of CoA in the mitochondrial matrix; homolog of human Graves disease protein SLC25A16, which complements yeast null mutant; does not encode an isozyme of Leu4p, as first hypothesized" NA Mitochondrial carrier protein NA Mitochondrial carrier protein LEU5 3 out of 5 NA "LEU5; coenzyme A transporter" NA LEUcine biosynthesis SLC25A16 transports cytosolic CoA-SH to mitichondrial matrix 2.A.29.12.4 Mitochondrial carrier protein LEU5 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=LEU5 PE=2 SV=1 FALSE +YIL048W r_3813 phosphatidyl-L-serine (1-16:0, 2-16:1)[erm] <=> phosphatidyl-L-serine (1-16:0, 2-16:1)[gm] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Leads to neomycin-resistance when overexpressed. Required for traffic between late Golgi and early endosomes. {ECO:0000269|PubMed:15314152, ECO:0000305}. MNXM78605 none "Phospholipid translocase (flippase), role in phospholipid asymmetry of plasma membrane; involved in endocytosis, vacuolar biogenesis and Golgi to ER vesicle-mediated transport; localizes to endosomes and the Golgi apparatus" 3.6.3.1 Phospholipid translocase (flippase), role in phospholipid asymmetry o 3.6.3.1 Probable phospholipid-transporting ATPase NEO1 (EC 3.6.3.1) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "NEO1; putative aminophospholipid-translocating P4-type ATPase NEO1" 3.6.3.1 NEOmycin-resistance NA 3.A.3.8.18 Probable phospholipid-transporting ATPase NEO1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NEO1 PE=1 SV=1 FALSE +YMR162C r_3813 phosphatidyl-L-serine (1-16:0, 2-16:1)[erm] <=> phosphatidyl-L-serine (1-16:0, 2-16:1)[gm] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Probable). Forms a heteromeric phospholipid translocase (PLT) DNF3-CRF1, implicated in the translocation of phospholipids from the outer to the inner leaflet of membrane bilayers. Shares an essential function for cell growth with PLTs DRS2-CDC50 and DNF1/2-LEM3. May be involved in transport from early endosomes to the trans-Golgi network (TGN) (Probable). {ECO:0000305, ECO:0000305|PubMed:17093059}. MNXM78605 none "Trans-golgi network aminophospholipid translocase (flippase); type 4 P-type ATPase; involved in phospholipid translocation, contributing to the maintenance of membrane lipid asymmetry in post-Golgi secretory vesicles; role in protein trafficking between the Golgi and endosomal system; localizes to the trans-Golgi network; localizes to the shmoo tip where it has a redundant role in the cellular response to mating pheromone" 3.6.3.1 Trans-golgi network aminophospholipid translocase (flippase) 3.6.3.1 Probable phospholipid-transporting ATPase DNF3 (EC 3.6.3.1) (Aminophospholipid translocase) (APT) (Phospholipid translocase) (PLT) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "DNF3; aminophospholipid-translocating P4-type ATPase DNF3" 3.6.3.1 Drs2 Neo1 Family NA 3.A.3.8.20 Probable phospholipid-transporting ATPase DNF3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=DNF3 PE=1 SV=1 FALSE +YIL048W r_3814 phosphatidyl-L-serine (1-16:1, 2-16:1)[erm] <=> phosphatidyl-L-serine (1-16:1, 2-16:1)[gm] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Leads to neomycin-resistance when overexpressed. Required for traffic between late Golgi and early endosomes. {ECO:0000269|PubMed:15314152, ECO:0000305}. NA none "Phospholipid translocase (flippase), role in phospholipid asymmetry of plasma membrane; involved in endocytosis, vacuolar biogenesis and Golgi to ER vesicle-mediated transport; localizes to endosomes and the Golgi apparatus" 3.6.3.1 Phospholipid translocase (flippase), role in phospholipid asymmetry o 3.6.3.1 Probable phospholipid-transporting ATPase NEO1 (EC 3.6.3.1) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "NEO1; putative aminophospholipid-translocating P4-type ATPase NEO1" 3.6.3.1 NEOmycin-resistance NA 3.A.3.8.18 Probable phospholipid-transporting ATPase NEO1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NEO1 PE=1 SV=1 FALSE +YMR162C r_3814 phosphatidyl-L-serine (1-16:1, 2-16:1)[erm] <=> phosphatidyl-L-serine (1-16:1, 2-16:1)[gm] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Probable). Forms a heteromeric phospholipid translocase (PLT) DNF3-CRF1, implicated in the translocation of phospholipids from the outer to the inner leaflet of membrane bilayers. Shares an essential function for cell growth with PLTs DRS2-CDC50 and DNF1/2-LEM3. May be involved in transport from early endosomes to the trans-Golgi network (TGN) (Probable). {ECO:0000305, ECO:0000305|PubMed:17093059}. NA none "Trans-golgi network aminophospholipid translocase (flippase); type 4 P-type ATPase; involved in phospholipid translocation, contributing to the maintenance of membrane lipid asymmetry in post-Golgi secretory vesicles; role in protein trafficking between the Golgi and endosomal system; localizes to the trans-Golgi network; localizes to the shmoo tip where it has a redundant role in the cellular response to mating pheromone" 3.6.3.1 Trans-golgi network aminophospholipid translocase (flippase) 3.6.3.1 Probable phospholipid-transporting ATPase DNF3 (EC 3.6.3.1) (Aminophospholipid translocase) (APT) (Phospholipid translocase) (PLT) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "DNF3; aminophospholipid-translocating P4-type ATPase DNF3" 3.6.3.1 Drs2 Neo1 Family NA 3.A.3.8.20 Probable phospholipid-transporting ATPase DNF3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=DNF3 PE=1 SV=1 FALSE +YIL048W r_3815 phosphatidyl-L-serine (1-18:0, 2-16:1)[erm] <=> phosphatidyl-L-serine (1-18:0, 2-16:1)[gm] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Leads to neomycin-resistance when overexpressed. Required for traffic between late Golgi and early endosomes. {ECO:0000269|PubMed:15314152, ECO:0000305}. MNXM78765 none "Phospholipid translocase (flippase), role in phospholipid asymmetry of plasma membrane; involved in endocytosis, vacuolar biogenesis and Golgi to ER vesicle-mediated transport; localizes to endosomes and the Golgi apparatus" 3.6.3.1 Phospholipid translocase (flippase), role in phospholipid asymmetry o 3.6.3.1 Probable phospholipid-transporting ATPase NEO1 (EC 3.6.3.1) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "NEO1; putative aminophospholipid-translocating P4-type ATPase NEO1" 3.6.3.1 NEOmycin-resistance NA 3.A.3.8.18 Probable phospholipid-transporting ATPase NEO1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NEO1 PE=1 SV=1 FALSE +YMR162C r_3815 phosphatidyl-L-serine (1-18:0, 2-16:1)[erm] <=> phosphatidyl-L-serine (1-18:0, 2-16:1)[gm] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Probable). Forms a heteromeric phospholipid translocase (PLT) DNF3-CRF1, implicated in the translocation of phospholipids from the outer to the inner leaflet of membrane bilayers. Shares an essential function for cell growth with PLTs DRS2-CDC50 and DNF1/2-LEM3. May be involved in transport from early endosomes to the trans-Golgi network (TGN) (Probable). {ECO:0000305, ECO:0000305|PubMed:17093059}. MNXM78765 none "Trans-golgi network aminophospholipid translocase (flippase); type 4 P-type ATPase; involved in phospholipid translocation, contributing to the maintenance of membrane lipid asymmetry in post-Golgi secretory vesicles; role in protein trafficking between the Golgi and endosomal system; localizes to the trans-Golgi network; localizes to the shmoo tip where it has a redundant role in the cellular response to mating pheromone" 3.6.3.1 Trans-golgi network aminophospholipid translocase (flippase) 3.6.3.1 Probable phospholipid-transporting ATPase DNF3 (EC 3.6.3.1) (Aminophospholipid translocase) (APT) (Phospholipid translocase) (PLT) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "DNF3; aminophospholipid-translocating P4-type ATPase DNF3" 3.6.3.1 Drs2 Neo1 Family NA 3.A.3.8.20 Probable phospholipid-transporting ATPase DNF3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=DNF3 PE=1 SV=1 FALSE +YIL048W r_3816 phosphatidyl-L-serine (1-18:1, 2-16:1)[erm] <=> phosphatidyl-L-serine (1-18:1, 2-16:1)[gm] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Leads to neomycin-resistance when overexpressed. Required for traffic between late Golgi and early endosomes. {ECO:0000269|PubMed:15314152, ECO:0000305}. MNXM78797 none "Phospholipid translocase (flippase), role in phospholipid asymmetry of plasma membrane; involved in endocytosis, vacuolar biogenesis and Golgi to ER vesicle-mediated transport; localizes to endosomes and the Golgi apparatus" 3.6.3.1 Phospholipid translocase (flippase), role in phospholipid asymmetry o 3.6.3.1 Probable phospholipid-transporting ATPase NEO1 (EC 3.6.3.1) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "NEO1; putative aminophospholipid-translocating P4-type ATPase NEO1" 3.6.3.1 NEOmycin-resistance NA 3.A.3.8.18 Probable phospholipid-transporting ATPase NEO1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NEO1 PE=1 SV=1 FALSE +YMR162C r_3816 phosphatidyl-L-serine (1-18:1, 2-16:1)[erm] <=> phosphatidyl-L-serine (1-18:1, 2-16:1)[gm] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Probable). Forms a heteromeric phospholipid translocase (PLT) DNF3-CRF1, implicated in the translocation of phospholipids from the outer to the inner leaflet of membrane bilayers. Shares an essential function for cell growth with PLTs DRS2-CDC50 and DNF1/2-LEM3. May be involved in transport from early endosomes to the trans-Golgi network (TGN) (Probable). {ECO:0000305, ECO:0000305|PubMed:17093059}. MNXM78797 none "Trans-golgi network aminophospholipid translocase (flippase); type 4 P-type ATPase; involved in phospholipid translocation, contributing to the maintenance of membrane lipid asymmetry in post-Golgi secretory vesicles; role in protein trafficking between the Golgi and endosomal system; localizes to the trans-Golgi network; localizes to the shmoo tip where it has a redundant role in the cellular response to mating pheromone" 3.6.3.1 Trans-golgi network aminophospholipid translocase (flippase) 3.6.3.1 Probable phospholipid-transporting ATPase DNF3 (EC 3.6.3.1) (Aminophospholipid translocase) (APT) (Phospholipid translocase) (PLT) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "DNF3; aminophospholipid-translocating P4-type ATPase DNF3" 3.6.3.1 Drs2 Neo1 Family NA 3.A.3.8.20 Probable phospholipid-transporting ATPase DNF3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=DNF3 PE=1 SV=1 FALSE +YIL048W r_3817 phosphatidyl-L-serine (1-16:0, 2-18:1)[erm] <=> phosphatidyl-L-serine (1-16:0, 2-18:1)[gm] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Leads to neomycin-resistance when overexpressed. Required for traffic between late Golgi and early endosomes. {ECO:0000269|PubMed:15314152, ECO:0000305}. MNXM680894 none "Phospholipid translocase (flippase), role in phospholipid asymmetry of plasma membrane; involved in endocytosis, vacuolar biogenesis and Golgi to ER vesicle-mediated transport; localizes to endosomes and the Golgi apparatus" 3.6.3.1 Phospholipid translocase (flippase), role in phospholipid asymmetry o 3.6.3.1 Probable phospholipid-transporting ATPase NEO1 (EC 3.6.3.1) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "NEO1; putative aminophospholipid-translocating P4-type ATPase NEO1" 3.6.3.1 NEOmycin-resistance NA 3.A.3.8.18 Probable phospholipid-transporting ATPase NEO1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NEO1 PE=1 SV=1 FALSE +YMR162C r_3817 phosphatidyl-L-serine (1-16:0, 2-18:1)[erm] <=> phosphatidyl-L-serine (1-16:0, 2-18:1)[gm] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Probable). Forms a heteromeric phospholipid translocase (PLT) DNF3-CRF1, implicated in the translocation of phospholipids from the outer to the inner leaflet of membrane bilayers. Shares an essential function for cell growth with PLTs DRS2-CDC50 and DNF1/2-LEM3. May be involved in transport from early endosomes to the trans-Golgi network (TGN) (Probable). {ECO:0000305, ECO:0000305|PubMed:17093059}. MNXM680894 none "Trans-golgi network aminophospholipid translocase (flippase); type 4 P-type ATPase; involved in phospholipid translocation, contributing to the maintenance of membrane lipid asymmetry in post-Golgi secretory vesicles; role in protein trafficking between the Golgi and endosomal system; localizes to the trans-Golgi network; localizes to the shmoo tip where it has a redundant role in the cellular response to mating pheromone" 3.6.3.1 Trans-golgi network aminophospholipid translocase (flippase) 3.6.3.1 Probable phospholipid-transporting ATPase DNF3 (EC 3.6.3.1) (Aminophospholipid translocase) (APT) (Phospholipid translocase) (PLT) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "DNF3; aminophospholipid-translocating P4-type ATPase DNF3" 3.6.3.1 Drs2 Neo1 Family NA 3.A.3.8.20 Probable phospholipid-transporting ATPase DNF3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=DNF3 PE=1 SV=1 FALSE +YIL048W r_3818 phosphatidyl-L-serine (1-16:1, 2-18:1)[erm] <=> phosphatidyl-L-serine (1-16:1, 2-18:1)[gm] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Leads to neomycin-resistance when overexpressed. Required for traffic between late Golgi and early endosomes. {ECO:0000269|PubMed:15314152, ECO:0000305}. MNXM78642 none "Phospholipid translocase (flippase), role in phospholipid asymmetry of plasma membrane; involved in endocytosis, vacuolar biogenesis and Golgi to ER vesicle-mediated transport; localizes to endosomes and the Golgi apparatus" 3.6.3.1 Phospholipid translocase (flippase), role in phospholipid asymmetry o 3.6.3.1 Probable phospholipid-transporting ATPase NEO1 (EC 3.6.3.1) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "NEO1; putative aminophospholipid-translocating P4-type ATPase NEO1" 3.6.3.1 NEOmycin-resistance NA 3.A.3.8.18 Probable phospholipid-transporting ATPase NEO1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NEO1 PE=1 SV=1 FALSE +YMR162C r_3818 phosphatidyl-L-serine (1-16:1, 2-18:1)[erm] <=> phosphatidyl-L-serine (1-16:1, 2-18:1)[gm] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Probable). Forms a heteromeric phospholipid translocase (PLT) DNF3-CRF1, implicated in the translocation of phospholipids from the outer to the inner leaflet of membrane bilayers. Shares an essential function for cell growth with PLTs DRS2-CDC50 and DNF1/2-LEM3. May be involved in transport from early endosomes to the trans-Golgi network (TGN) (Probable). {ECO:0000305, ECO:0000305|PubMed:17093059}. MNXM78642 none "Trans-golgi network aminophospholipid translocase (flippase); type 4 P-type ATPase; involved in phospholipid translocation, contributing to the maintenance of membrane lipid asymmetry in post-Golgi secretory vesicles; role in protein trafficking between the Golgi and endosomal system; localizes to the trans-Golgi network; localizes to the shmoo tip where it has a redundant role in the cellular response to mating pheromone" 3.6.3.1 Trans-golgi network aminophospholipid translocase (flippase) 3.6.3.1 Probable phospholipid-transporting ATPase DNF3 (EC 3.6.3.1) (Aminophospholipid translocase) (APT) (Phospholipid translocase) (PLT) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "DNF3; aminophospholipid-translocating P4-type ATPase DNF3" 3.6.3.1 Drs2 Neo1 Family NA 3.A.3.8.20 Probable phospholipid-transporting ATPase DNF3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=DNF3 PE=1 SV=1 FALSE +YIL048W r_3819 phosphatidyl-L-serine (1-18:0, 2-18:1)[erm] <=> phosphatidyl-L-serine (1-18:0, 2-18:1)[gm] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Leads to neomycin-resistance when overexpressed. Required for traffic between late Golgi and early endosomes. {ECO:0000269|PubMed:15314152, ECO:0000305}. MNXM680500 none "Phospholipid translocase (flippase), role in phospholipid asymmetry of plasma membrane; involved in endocytosis, vacuolar biogenesis and Golgi to ER vesicle-mediated transport; localizes to endosomes and the Golgi apparatus" 3.6.3.1 Phospholipid translocase (flippase), role in phospholipid asymmetry o 3.6.3.1 Probable phospholipid-transporting ATPase NEO1 (EC 3.6.3.1) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "NEO1; putative aminophospholipid-translocating P4-type ATPase NEO1" 3.6.3.1 NEOmycin-resistance NA 3.A.3.8.18 Probable phospholipid-transporting ATPase NEO1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NEO1 PE=1 SV=1 FALSE +YMR162C r_3819 phosphatidyl-L-serine (1-18:0, 2-18:1)[erm] <=> phosphatidyl-L-serine (1-18:0, 2-18:1)[gm] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Probable). Forms a heteromeric phospholipid translocase (PLT) DNF3-CRF1, implicated in the translocation of phospholipids from the outer to the inner leaflet of membrane bilayers. Shares an essential function for cell growth with PLTs DRS2-CDC50 and DNF1/2-LEM3. May be involved in transport from early endosomes to the trans-Golgi network (TGN) (Probable). {ECO:0000305, ECO:0000305|PubMed:17093059}. MNXM680500 none "Trans-golgi network aminophospholipid translocase (flippase); type 4 P-type ATPase; involved in phospholipid translocation, contributing to the maintenance of membrane lipid asymmetry in post-Golgi secretory vesicles; role in protein trafficking between the Golgi and endosomal system; localizes to the trans-Golgi network; localizes to the shmoo tip where it has a redundant role in the cellular response to mating pheromone" 3.6.3.1 Trans-golgi network aminophospholipid translocase (flippase) 3.6.3.1 Probable phospholipid-transporting ATPase DNF3 (EC 3.6.3.1) (Aminophospholipid translocase) (APT) (Phospholipid translocase) (PLT) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "DNF3; aminophospholipid-translocating P4-type ATPase DNF3" 3.6.3.1 Drs2 Neo1 Family NA 3.A.3.8.20 Probable phospholipid-transporting ATPase DNF3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=DNF3 PE=1 SV=1 FALSE +YIL048W r_3820 phosphatidyl-L-serine (1-18:1, 2-18:1)[erm] <=> phosphatidyl-L-serine (1-18:1, 2-18:1)[gm] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Leads to neomycin-resistance when overexpressed. Required for traffic between late Golgi and early endosomes. {ECO:0000269|PubMed:15314152, ECO:0000305}. MNXM32173 none "Phospholipid translocase (flippase), role in phospholipid asymmetry of plasma membrane; involved in endocytosis, vacuolar biogenesis and Golgi to ER vesicle-mediated transport; localizes to endosomes and the Golgi apparatus" 3.6.3.1 Phospholipid translocase (flippase), role in phospholipid asymmetry o 3.6.3.1 Probable phospholipid-transporting ATPase NEO1 (EC 3.6.3.1) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "NEO1; putative aminophospholipid-translocating P4-type ATPase NEO1" 3.6.3.1 NEOmycin-resistance NA 3.A.3.8.18 Probable phospholipid-transporting ATPase NEO1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NEO1 PE=1 SV=1 FALSE +YMR162C r_3820 phosphatidyl-L-serine (1-18:1, 2-18:1)[erm] <=> phosphatidyl-L-serine (1-18:1, 2-18:1)[gm] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Probable). Forms a heteromeric phospholipid translocase (PLT) DNF3-CRF1, implicated in the translocation of phospholipids from the outer to the inner leaflet of membrane bilayers. Shares an essential function for cell growth with PLTs DRS2-CDC50 and DNF1/2-LEM3. May be involved in transport from early endosomes to the trans-Golgi network (TGN) (Probable). {ECO:0000305, ECO:0000305|PubMed:17093059}. MNXM32173 none "Trans-golgi network aminophospholipid translocase (flippase); type 4 P-type ATPase; involved in phospholipid translocation, contributing to the maintenance of membrane lipid asymmetry in post-Golgi secretory vesicles; role in protein trafficking between the Golgi and endosomal system; localizes to the trans-Golgi network; localizes to the shmoo tip where it has a redundant role in the cellular response to mating pheromone" 3.6.3.1 Trans-golgi network aminophospholipid translocase (flippase) 3.6.3.1 Probable phospholipid-transporting ATPase DNF3 (EC 3.6.3.1) (Aminophospholipid translocase) (APT) (Phospholipid translocase) (PLT) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "DNF3; aminophospholipid-translocating P4-type ATPase DNF3" 3.6.3.1 Drs2 Neo1 Family NA 3.A.3.8.20 Probable phospholipid-transporting ATPase DNF3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=DNF3 PE=1 SV=1 FALSE +YAL026C r_3821 phosphatidylethanolamine (1-16:0, 2-16:1)[gm] <=> phosphatidylethanolamine (1-16:0, 2-16:1)[erm] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Seems to be involved in ribosome assembly. {ECO:0000305}. MNXM588855 none "Trans-golgi network aminophospholipid translocase (flippase); maintains membrane lipid asymmetry in post-Golgi secretory vesicles; contributes to clathrin-coated vesicle formation, endocytosis, protein trafficking between the Golgi and endosomal system and the cellular response to mating pheromone; autoinhibited by its C-terminal tail; localizes to the trans-Golgi network; mutations in human homolog ATP8B1 result in liver disease" 3.6.3.1 Trans-golgi network aminophospholipid translocase (flippase) 3.6.3.1 Probable phospholipid-transporting ATPase DRS2 (EC 3.6.3.1) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "DRS2, FUN38, SWA3; aminophospholipid-translocating P4-type ATPase DRS2" 3.6.3.1 Deficiency of Ribosomal Subunits "Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane" 3.A.3.8.2 POTENTIAL PHOSPHOLIPID-TRANSPORTING ATPASE 1 (EC 3.6.3.13) - Saccharomyces cerevisiae (Baker's yeast). FALSE +YAL026C r_3822 phosphatidylethanolamine (1-16:1, 2-16:1)[gm] <=> phosphatidylethanolamine (1-16:1, 2-16:1)[erm] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Seems to be involved in ribosome assembly. {ECO:0000305}. NA none "Trans-golgi network aminophospholipid translocase (flippase); maintains membrane lipid asymmetry in post-Golgi secretory vesicles; contributes to clathrin-coated vesicle formation, endocytosis, protein trafficking between the Golgi and endosomal system and the cellular response to mating pheromone; autoinhibited by its C-terminal tail; localizes to the trans-Golgi network; mutations in human homolog ATP8B1 result in liver disease" 3.6.3.1 Trans-golgi network aminophospholipid translocase (flippase) 3.6.3.1 Probable phospholipid-transporting ATPase DRS2 (EC 3.6.3.1) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "DRS2, FUN38, SWA3; aminophospholipid-translocating P4-type ATPase DRS2" 3.6.3.1 Deficiency of Ribosomal Subunits "Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane" 3.A.3.8.2 POTENTIAL PHOSPHOLIPID-TRANSPORTING ATPASE 1 (EC 3.6.3.13) - Saccharomyces cerevisiae (Baker's yeast). FALSE +YAL026C r_3823 phosphatidylethanolamine (1-18:0, 2-16:1)[gm] <=> phosphatidylethanolamine (1-18:0, 2-16:1)[erm] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Seems to be involved in ribosome assembly. {ECO:0000305}. MNXM588866 none "Trans-golgi network aminophospholipid translocase (flippase); maintains membrane lipid asymmetry in post-Golgi secretory vesicles; contributes to clathrin-coated vesicle formation, endocytosis, protein trafficking between the Golgi and endosomal system and the cellular response to mating pheromone; autoinhibited by its C-terminal tail; localizes to the trans-Golgi network; mutations in human homolog ATP8B1 result in liver disease" 3.6.3.1 Trans-golgi network aminophospholipid translocase (flippase) 3.6.3.1 Probable phospholipid-transporting ATPase DRS2 (EC 3.6.3.1) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "DRS2, FUN38, SWA3; aminophospholipid-translocating P4-type ATPase DRS2" 3.6.3.1 Deficiency of Ribosomal Subunits "Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane" 3.A.3.8.2 POTENTIAL PHOSPHOLIPID-TRANSPORTING ATPASE 1 (EC 3.6.3.13) - Saccharomyces cerevisiae (Baker's yeast). FALSE +YAL026C r_3824 phosphatidylethanolamine (1-18:1, 2-16:1)[gm] <=> phosphatidylethanolamine (1-18:1, 2-16:1)[erm] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Seems to be involved in ribosome assembly. {ECO:0000305}. MNXM71684 none "Trans-golgi network aminophospholipid translocase (flippase); maintains membrane lipid asymmetry in post-Golgi secretory vesicles; contributes to clathrin-coated vesicle formation, endocytosis, protein trafficking between the Golgi and endosomal system and the cellular response to mating pheromone; autoinhibited by its C-terminal tail; localizes to the trans-Golgi network; mutations in human homolog ATP8B1 result in liver disease" 3.6.3.1 Trans-golgi network aminophospholipid translocase (flippase) 3.6.3.1 Probable phospholipid-transporting ATPase DRS2 (EC 3.6.3.1) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "DRS2, FUN38, SWA3; aminophospholipid-translocating P4-type ATPase DRS2" 3.6.3.1 Deficiency of Ribosomal Subunits "Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane" 3.A.3.8.2 POTENTIAL PHOSPHOLIPID-TRANSPORTING ATPASE 1 (EC 3.6.3.13) - Saccharomyces cerevisiae (Baker's yeast). FALSE +YAL026C r_3825 phosphatidylethanolamine (1-16:0, 2-18:1)[gm] <=> phosphatidylethanolamine (1-16:0, 2-18:1)[erm] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Seems to be involved in ribosome assembly. {ECO:0000305}. MNXM588857 none "Trans-golgi network aminophospholipid translocase (flippase); maintains membrane lipid asymmetry in post-Golgi secretory vesicles; contributes to clathrin-coated vesicle formation, endocytosis, protein trafficking between the Golgi and endosomal system and the cellular response to mating pheromone; autoinhibited by its C-terminal tail; localizes to the trans-Golgi network; mutations in human homolog ATP8B1 result in liver disease" 3.6.3.1 Trans-golgi network aminophospholipid translocase (flippase) 3.6.3.1 Probable phospholipid-transporting ATPase DRS2 (EC 3.6.3.1) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "DRS2, FUN38, SWA3; aminophospholipid-translocating P4-type ATPase DRS2" 3.6.3.1 Deficiency of Ribosomal Subunits "Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane" 3.A.3.8.2 POTENTIAL PHOSPHOLIPID-TRANSPORTING ATPASE 1 (EC 3.6.3.13) - Saccharomyces cerevisiae (Baker's yeast). FALSE +YAL026C r_3826 phosphatidylethanolamine (1-16:1, 2-18:1)[gm] <=> phosphatidylethanolamine (1-16:1, 2-18:1)[erm] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Seems to be involved in ribosome assembly. {ECO:0000305}. MNXM611809 none "Trans-golgi network aminophospholipid translocase (flippase); maintains membrane lipid asymmetry in post-Golgi secretory vesicles; contributes to clathrin-coated vesicle formation, endocytosis, protein trafficking between the Golgi and endosomal system and the cellular response to mating pheromone; autoinhibited by its C-terminal tail; localizes to the trans-Golgi network; mutations in human homolog ATP8B1 result in liver disease" 3.6.3.1 Trans-golgi network aminophospholipid translocase (flippase) 3.6.3.1 Probable phospholipid-transporting ATPase DRS2 (EC 3.6.3.1) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "DRS2, FUN38, SWA3; aminophospholipid-translocating P4-type ATPase DRS2" 3.6.3.1 Deficiency of Ribosomal Subunits "Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane" 3.A.3.8.2 POTENTIAL PHOSPHOLIPID-TRANSPORTING ATPASE 1 (EC 3.6.3.13) - Saccharomyces cerevisiae (Baker's yeast). FALSE +YAL026C r_3827 phosphatidylethanolamine (1-18:0, 2-18:1)[gm] <=> phosphatidylethanolamine (1-18:0, 2-18:1)[erm] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Seems to be involved in ribosome assembly. {ECO:0000305}. MNXM588872 none "Trans-golgi network aminophospholipid translocase (flippase); maintains membrane lipid asymmetry in post-Golgi secretory vesicles; contributes to clathrin-coated vesicle formation, endocytosis, protein trafficking between the Golgi and endosomal system and the cellular response to mating pheromone; autoinhibited by its C-terminal tail; localizes to the trans-Golgi network; mutations in human homolog ATP8B1 result in liver disease" 3.6.3.1 Trans-golgi network aminophospholipid translocase (flippase) 3.6.3.1 Probable phospholipid-transporting ATPase DRS2 (EC 3.6.3.1) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "DRS2, FUN38, SWA3; aminophospholipid-translocating P4-type ATPase DRS2" 3.6.3.1 Deficiency of Ribosomal Subunits "Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane" 3.A.3.8.2 POTENTIAL PHOSPHOLIPID-TRANSPORTING ATPASE 1 (EC 3.6.3.13) - Saccharomyces cerevisiae (Baker's yeast). FALSE +YAL026C r_3828 phosphatidylethanolamine (1-18:1, 2-18:1)[gm] <=> phosphatidylethanolamine (1-18:1, 2-18:1)[erm] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Seems to be involved in ribosome assembly. {ECO:0000305}. MNXM588883 none "Trans-golgi network aminophospholipid translocase (flippase); maintains membrane lipid asymmetry in post-Golgi secretory vesicles; contributes to clathrin-coated vesicle formation, endocytosis, protein trafficking between the Golgi and endosomal system and the cellular response to mating pheromone; autoinhibited by its C-terminal tail; localizes to the trans-Golgi network; mutations in human homolog ATP8B1 result in liver disease" 3.6.3.1 Trans-golgi network aminophospholipid translocase (flippase) 3.6.3.1 Probable phospholipid-transporting ATPase DRS2 (EC 3.6.3.1) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "DRS2, FUN38, SWA3; aminophospholipid-translocating P4-type ATPase DRS2" 3.6.3.1 Deficiency of Ribosomal Subunits "Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane" 3.A.3.8.2 POTENTIAL PHOSPHOLIPID-TRANSPORTING ATPASE 1 (EC 3.6.3.13) - Saccharomyces cerevisiae (Baker's yeast). FALSE +YAL026C r_3885 phosphatidylethanolamine (1-16:0, 2-16:1)[erm] <=> phosphatidylethanolamine (1-16:0, 2-16:1)[ce] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Seems to be involved in ribosome assembly. {ECO:0000305}. MNXM588855 none "Trans-golgi network aminophospholipid translocase (flippase); maintains membrane lipid asymmetry in post-Golgi secretory vesicles; contributes to clathrin-coated vesicle formation, endocytosis, protein trafficking between the Golgi and endosomal system and the cellular response to mating pheromone; autoinhibited by its C-terminal tail; localizes to the trans-Golgi network; mutations in human homolog ATP8B1 result in liver disease" 3.6.3.1 Trans-golgi network aminophospholipid translocase (flippase) 3.6.3.1 Probable phospholipid-transporting ATPase DRS2 (EC 3.6.3.1) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "DRS2, FUN38, SWA3; aminophospholipid-translocating P4-type ATPase DRS2" 3.6.3.1 Deficiency of Ribosomal Subunits "Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane" 3.A.3.8.2 POTENTIAL PHOSPHOLIPID-TRANSPORTING ATPASE 1 (EC 3.6.3.13) - Saccharomyces cerevisiae (Baker's yeast). FALSE +YAL026C r_3886 phosphatidylethanolamine (1-16:1, 2-16:1)[erm] <=> phosphatidylethanolamine (1-16:1, 2-16:1)[ce] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Seems to be involved in ribosome assembly. {ECO:0000305}. NA none "Trans-golgi network aminophospholipid translocase (flippase); maintains membrane lipid asymmetry in post-Golgi secretory vesicles; contributes to clathrin-coated vesicle formation, endocytosis, protein trafficking between the Golgi and endosomal system and the cellular response to mating pheromone; autoinhibited by its C-terminal tail; localizes to the trans-Golgi network; mutations in human homolog ATP8B1 result in liver disease" 3.6.3.1 Trans-golgi network aminophospholipid translocase (flippase) 3.6.3.1 Probable phospholipid-transporting ATPase DRS2 (EC 3.6.3.1) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "DRS2, FUN38, SWA3; aminophospholipid-translocating P4-type ATPase DRS2" 3.6.3.1 Deficiency of Ribosomal Subunits "Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane" 3.A.3.8.2 POTENTIAL PHOSPHOLIPID-TRANSPORTING ATPASE 1 (EC 3.6.3.13) - Saccharomyces cerevisiae (Baker's yeast). FALSE +YAL026C r_3887 phosphatidylethanolamine (1-18:0, 2-16:1)[erm] <=> phosphatidylethanolamine (1-18:0, 2-16:1)[ce] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Seems to be involved in ribosome assembly. {ECO:0000305}. MNXM588866 none "Trans-golgi network aminophospholipid translocase (flippase); maintains membrane lipid asymmetry in post-Golgi secretory vesicles; contributes to clathrin-coated vesicle formation, endocytosis, protein trafficking between the Golgi and endosomal system and the cellular response to mating pheromone; autoinhibited by its C-terminal tail; localizes to the trans-Golgi network; mutations in human homolog ATP8B1 result in liver disease" 3.6.3.1 Trans-golgi network aminophospholipid translocase (flippase) 3.6.3.1 Probable phospholipid-transporting ATPase DRS2 (EC 3.6.3.1) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "DRS2, FUN38, SWA3; aminophospholipid-translocating P4-type ATPase DRS2" 3.6.3.1 Deficiency of Ribosomal Subunits "Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane" 3.A.3.8.2 POTENTIAL PHOSPHOLIPID-TRANSPORTING ATPASE 1 (EC 3.6.3.13) - Saccharomyces cerevisiae (Baker's yeast). FALSE +YAL026C r_3888 phosphatidylethanolamine (1-18:1, 2-16:1)[erm] <=> phosphatidylethanolamine (1-18:1, 2-16:1)[ce] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Seems to be involved in ribosome assembly. {ECO:0000305}. MNXM71684 none "Trans-golgi network aminophospholipid translocase (flippase); maintains membrane lipid asymmetry in post-Golgi secretory vesicles; contributes to clathrin-coated vesicle formation, endocytosis, protein trafficking between the Golgi and endosomal system and the cellular response to mating pheromone; autoinhibited by its C-terminal tail; localizes to the trans-Golgi network; mutations in human homolog ATP8B1 result in liver disease" 3.6.3.1 Trans-golgi network aminophospholipid translocase (flippase) 3.6.3.1 Probable phospholipid-transporting ATPase DRS2 (EC 3.6.3.1) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "DRS2, FUN38, SWA3; aminophospholipid-translocating P4-type ATPase DRS2" 3.6.3.1 Deficiency of Ribosomal Subunits "Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane" 3.A.3.8.2 POTENTIAL PHOSPHOLIPID-TRANSPORTING ATPASE 1 (EC 3.6.3.13) - Saccharomyces cerevisiae (Baker's yeast). FALSE +YAL026C r_3889 phosphatidylethanolamine (1-16:0, 2-18:1)[erm] <=> phosphatidylethanolamine (1-16:0, 2-18:1)[ce] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Seems to be involved in ribosome assembly. {ECO:0000305}. MNXM588857 none "Trans-golgi network aminophospholipid translocase (flippase); maintains membrane lipid asymmetry in post-Golgi secretory vesicles; contributes to clathrin-coated vesicle formation, endocytosis, protein trafficking between the Golgi and endosomal system and the cellular response to mating pheromone; autoinhibited by its C-terminal tail; localizes to the trans-Golgi network; mutations in human homolog ATP8B1 result in liver disease" 3.6.3.1 Trans-golgi network aminophospholipid translocase (flippase) 3.6.3.1 Probable phospholipid-transporting ATPase DRS2 (EC 3.6.3.1) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "DRS2, FUN38, SWA3; aminophospholipid-translocating P4-type ATPase DRS2" 3.6.3.1 Deficiency of Ribosomal Subunits "Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane" 3.A.3.8.2 POTENTIAL PHOSPHOLIPID-TRANSPORTING ATPASE 1 (EC 3.6.3.13) - Saccharomyces cerevisiae (Baker's yeast). FALSE +YAL026C r_3890 phosphatidylethanolamine (1-16:1, 2-18:1)[erm] <=> phosphatidylethanolamine (1-16:1, 2-18:1)[ce] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Seems to be involved in ribosome assembly. {ECO:0000305}. MNXM611809 none "Trans-golgi network aminophospholipid translocase (flippase); maintains membrane lipid asymmetry in post-Golgi secretory vesicles; contributes to clathrin-coated vesicle formation, endocytosis, protein trafficking between the Golgi and endosomal system and the cellular response to mating pheromone; autoinhibited by its C-terminal tail; localizes to the trans-Golgi network; mutations in human homolog ATP8B1 result in liver disease" 3.6.3.1 Trans-golgi network aminophospholipid translocase (flippase) 3.6.3.1 Probable phospholipid-transporting ATPase DRS2 (EC 3.6.3.1) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "DRS2, FUN38, SWA3; aminophospholipid-translocating P4-type ATPase DRS2" 3.6.3.1 Deficiency of Ribosomal Subunits "Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane" 3.A.3.8.2 POTENTIAL PHOSPHOLIPID-TRANSPORTING ATPASE 1 (EC 3.6.3.13) - Saccharomyces cerevisiae (Baker's yeast). FALSE +YAL026C r_3891 phosphatidylethanolamine (1-18:0, 2-18:1)[erm] <=> phosphatidylethanolamine (1-18:0, 2-18:1)[ce] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Seems to be involved in ribosome assembly. {ECO:0000305}. MNXM588872 none "Trans-golgi network aminophospholipid translocase (flippase); maintains membrane lipid asymmetry in post-Golgi secretory vesicles; contributes to clathrin-coated vesicle formation, endocytosis, protein trafficking between the Golgi and endosomal system and the cellular response to mating pheromone; autoinhibited by its C-terminal tail; localizes to the trans-Golgi network; mutations in human homolog ATP8B1 result in liver disease" 3.6.3.1 Trans-golgi network aminophospholipid translocase (flippase) 3.6.3.1 Probable phospholipid-transporting ATPase DRS2 (EC 3.6.3.1) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "DRS2, FUN38, SWA3; aminophospholipid-translocating P4-type ATPase DRS2" 3.6.3.1 Deficiency of Ribosomal Subunits "Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane" 3.A.3.8.2 POTENTIAL PHOSPHOLIPID-TRANSPORTING ATPASE 1 (EC 3.6.3.13) - Saccharomyces cerevisiae (Baker's yeast). FALSE +YAL026C r_3892 phosphatidylethanolamine (1-18:1, 2-18:1)[erm] <=> phosphatidylethanolamine (1-18:1, 2-18:1)[ce] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Seems to be involved in ribosome assembly. {ECO:0000305}. MNXM588883 none "Trans-golgi network aminophospholipid translocase (flippase); maintains membrane lipid asymmetry in post-Golgi secretory vesicles; contributes to clathrin-coated vesicle formation, endocytosis, protein trafficking between the Golgi and endosomal system and the cellular response to mating pheromone; autoinhibited by its C-terminal tail; localizes to the trans-Golgi network; mutations in human homolog ATP8B1 result in liver disease" 3.6.3.1 Trans-golgi network aminophospholipid translocase (flippase) 3.6.3.1 Probable phospholipid-transporting ATPase DRS2 (EC 3.6.3.1) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "DRS2, FUN38, SWA3; aminophospholipid-translocating P4-type ATPase DRS2" 3.6.3.1 Deficiency of Ribosomal Subunits "Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of azurophil granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of tertiary granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane" 3.A.3.8.2 POTENTIAL PHOSPHOLIPID-TRANSPORTING ATPASE 1 (EC 3.6.3.13) - Saccharomyces cerevisiae (Baker's yeast). FALSE +YIL048W r_3893 phosphatidyl-L-serine (1-16:0, 2-16:1)[erm] <=> phosphatidyl-L-serine (1-16:0, 2-16:1)[ce] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Leads to neomycin-resistance when overexpressed. Required for traffic between late Golgi and early endosomes. {ECO:0000269|PubMed:15314152, ECO:0000305}. MNXM78605 none "Phospholipid translocase (flippase), role in phospholipid asymmetry of plasma membrane; involved in endocytosis, vacuolar biogenesis and Golgi to ER vesicle-mediated transport; localizes to endosomes and the Golgi apparatus" 3.6.3.1 Phospholipid translocase (flippase), role in phospholipid asymmetry o 3.6.3.1 Probable phospholipid-transporting ATPase NEO1 (EC 3.6.3.1) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "NEO1; putative aminophospholipid-translocating P4-type ATPase NEO1" 3.6.3.1 NEOmycin-resistance NA 3.A.3.8.18 Probable phospholipid-transporting ATPase NEO1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NEO1 PE=1 SV=1 FALSE +YIL048W r_3894 phosphatidyl-L-serine (1-16:1, 2-16:1)[erm] <=> phosphatidyl-L-serine (1-16:1, 2-16:1)[ce] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Leads to neomycin-resistance when overexpressed. Required for traffic between late Golgi and early endosomes. {ECO:0000269|PubMed:15314152, ECO:0000305}. NA none "Phospholipid translocase (flippase), role in phospholipid asymmetry of plasma membrane; involved in endocytosis, vacuolar biogenesis and Golgi to ER vesicle-mediated transport; localizes to endosomes and the Golgi apparatus" 3.6.3.1 Phospholipid translocase (flippase), role in phospholipid asymmetry o 3.6.3.1 Probable phospholipid-transporting ATPase NEO1 (EC 3.6.3.1) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "NEO1; putative aminophospholipid-translocating P4-type ATPase NEO1" 3.6.3.1 NEOmycin-resistance NA 3.A.3.8.18 Probable phospholipid-transporting ATPase NEO1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NEO1 PE=1 SV=1 FALSE +YIL048W r_3895 phosphatidyl-L-serine (1-18:0, 2-16:1)[erm] <=> phosphatidyl-L-serine (1-18:0, 2-16:1)[ce] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Leads to neomycin-resistance when overexpressed. Required for traffic between late Golgi and early endosomes. {ECO:0000269|PubMed:15314152, ECO:0000305}. MNXM78765 none "Phospholipid translocase (flippase), role in phospholipid asymmetry of plasma membrane; involved in endocytosis, vacuolar biogenesis and Golgi to ER vesicle-mediated transport; localizes to endosomes and the Golgi apparatus" 3.6.3.1 Phospholipid translocase (flippase), role in phospholipid asymmetry o 3.6.3.1 Probable phospholipid-transporting ATPase NEO1 (EC 3.6.3.1) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "NEO1; putative aminophospholipid-translocating P4-type ATPase NEO1" 3.6.3.1 NEOmycin-resistance NA 3.A.3.8.18 Probable phospholipid-transporting ATPase NEO1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NEO1 PE=1 SV=1 FALSE +YIL048W r_3896 phosphatidyl-L-serine (1-18:1, 2-16:1)[erm] <=> phosphatidyl-L-serine (1-18:1, 2-16:1)[ce] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Leads to neomycin-resistance when overexpressed. Required for traffic between late Golgi and early endosomes. {ECO:0000269|PubMed:15314152, ECO:0000305}. MNXM78797 none "Phospholipid translocase (flippase), role in phospholipid asymmetry of plasma membrane; involved in endocytosis, vacuolar biogenesis and Golgi to ER vesicle-mediated transport; localizes to endosomes and the Golgi apparatus" 3.6.3.1 Phospholipid translocase (flippase), role in phospholipid asymmetry o 3.6.3.1 Probable phospholipid-transporting ATPase NEO1 (EC 3.6.3.1) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "NEO1; putative aminophospholipid-translocating P4-type ATPase NEO1" 3.6.3.1 NEOmycin-resistance NA 3.A.3.8.18 Probable phospholipid-transporting ATPase NEO1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NEO1 PE=1 SV=1 FALSE +YIL048W r_3897 phosphatidyl-L-serine (1-16:0, 2-18:1)[erm] <=> phosphatidyl-L-serine (1-16:0, 2-18:1)[ce] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Leads to neomycin-resistance when overexpressed. Required for traffic between late Golgi and early endosomes. {ECO:0000269|PubMed:15314152, ECO:0000305}. MNXM680894 none "Phospholipid translocase (flippase), role in phospholipid asymmetry of plasma membrane; involved in endocytosis, vacuolar biogenesis and Golgi to ER vesicle-mediated transport; localizes to endosomes and the Golgi apparatus" 3.6.3.1 Phospholipid translocase (flippase), role in phospholipid asymmetry o 3.6.3.1 Probable phospholipid-transporting ATPase NEO1 (EC 3.6.3.1) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "NEO1; putative aminophospholipid-translocating P4-type ATPase NEO1" 3.6.3.1 NEOmycin-resistance NA 3.A.3.8.18 Probable phospholipid-transporting ATPase NEO1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NEO1 PE=1 SV=1 FALSE +YIL048W r_3898 phosphatidyl-L-serine (1-16:1, 2-18:1)[erm] <=> phosphatidyl-L-serine (1-16:1, 2-18:1)[ce] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Leads to neomycin-resistance when overexpressed. Required for traffic between late Golgi and early endosomes. {ECO:0000269|PubMed:15314152, ECO:0000305}. MNXM78642 none "Phospholipid translocase (flippase), role in phospholipid asymmetry of plasma membrane; involved in endocytosis, vacuolar biogenesis and Golgi to ER vesicle-mediated transport; localizes to endosomes and the Golgi apparatus" 3.6.3.1 Phospholipid translocase (flippase), role in phospholipid asymmetry o 3.6.3.1 Probable phospholipid-transporting ATPase NEO1 (EC 3.6.3.1) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "NEO1; putative aminophospholipid-translocating P4-type ATPase NEO1" 3.6.3.1 NEOmycin-resistance NA 3.A.3.8.18 Probable phospholipid-transporting ATPase NEO1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NEO1 PE=1 SV=1 FALSE +YIL048W r_3899 phosphatidyl-L-serine (1-18:0, 2-18:1)[erm] <=> phosphatidyl-L-serine (1-18:0, 2-18:1)[ce] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Leads to neomycin-resistance when overexpressed. Required for traffic between late Golgi and early endosomes. {ECO:0000269|PubMed:15314152, ECO:0000305}. MNXM680500 none "Phospholipid translocase (flippase), role in phospholipid asymmetry of plasma membrane; involved in endocytosis, vacuolar biogenesis and Golgi to ER vesicle-mediated transport; localizes to endosomes and the Golgi apparatus" 3.6.3.1 Phospholipid translocase (flippase), role in phospholipid asymmetry o 3.6.3.1 Probable phospholipid-transporting ATPase NEO1 (EC 3.6.3.1) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "NEO1; putative aminophospholipid-translocating P4-type ATPase NEO1" 3.6.3.1 NEOmycin-resistance NA 3.A.3.8.18 Probable phospholipid-transporting ATPase NEO1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NEO1 PE=1 SV=1 FALSE +YIL048W r_3900 phosphatidyl-L-serine (1-18:1, 2-18:1)[erm] <=> phosphatidyl-L-serine (1-18:1, 2-18:1)[ce] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Leads to neomycin-resistance when overexpressed. Required for traffic between late Golgi and early endosomes. {ECO:0000269|PubMed:15314152, ECO:0000305}. MNXM32173 none "Phospholipid translocase (flippase), role in phospholipid asymmetry of plasma membrane; involved in endocytosis, vacuolar biogenesis and Golgi to ER vesicle-mediated transport; localizes to endosomes and the Golgi apparatus" 3.6.3.1 Phospholipid translocase (flippase), role in phospholipid asymmetry o 3.6.3.1 Probable phospholipid-transporting ATPase NEO1 (EC 3.6.3.1) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "NEO1; putative aminophospholipid-translocating P4-type ATPase NEO1" 3.6.3.1 NEOmycin-resistance NA 3.A.3.8.18 Probable phospholipid-transporting ATPase NEO1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NEO1 PE=1 SV=1 FALSE +YBR192W r_3959 CMP[m] <=> CMP[mm] NA MNXM31 none "Mitochondrial pyrimidine nucleotide transporter; imports pyrimidine nucleoside triphosphates and exports pyrimidine nucleoside monophosphates; member of the mitochondrial carrier family" NA Mitochondrial pyrimidine nucleotide transporter NA Mitochondrial carrier protein RIM2 4 out of 5 NA "RIM2, PYT1; Rim2p" NA Replication In Mitochondria NA 2.A.29.10.4 2.A.29.10.4 Mitochondrial carrier protein RIM2 FALSE +YBR192W r_3960 CTP[m] <=> CTP[mm] NA MNXM63 none "Mitochondrial pyrimidine nucleotide transporter; imports pyrimidine nucleoside triphosphates and exports pyrimidine nucleoside monophosphates; member of the mitochondrial carrier family" NA Mitochondrial pyrimidine nucleotide transporter NA Mitochondrial carrier protein RIM2 4 out of 5 NA "RIM2, PYT1; Rim2p" NA Replication In Mitochondria NA 2.A.29.10.4 2.A.29.10.4 Mitochondrial carrier protein RIM2 FALSE +YER053C r_3961 phosphate[m] <=> phosphate[mm] Transport of phosphate groups from the cytosol to the mitochondrial matrix. {ECO:0000269|PubMed:11328608, ECO:0000269|PubMed:14756774}. MNXM9 none "Mitochondrial copper and phosphate carrier; imports copper and inorganic phosphate into mitochondria; functionally redundant with Mir1p but less abundant than Mir1p under normal conditions; expression is induced at high temperature" NA Mitochondrial copper and phosphate carrier NA Mitochondrial phosphate carrier protein 2 (Phosphate transport protein 2) (PTP 2) (Pi carrier isoform 2) (mPic 2) 5 out of 5 NA "PIC2; Cu/Pi carrier" NA PI Carrier NA 2.A.29.4.4 Mitochondrial phosphate carrier protein 2 OS=Saccharomyces cerevisiae GN=PIC2 PE=1 SV=1 FALSE +YJR077C r_3961 phosphate[m] <=> phosphate[mm] Transport of phosphate groups from the cytosol to the mitochondrial matrix. MNXM9 none "Mitochondrial phosphate carrier; imports inorganic phosphate into mitochondria; functionally redundant with Pic2p but more abundant than Pic2p under normal conditions; phosphorylated" NA Mitochondrial phosphate carrier NA Mitochondrial phosphate carrier protein (Mitochondrial import receptor) (Phosphate transport protein) (PTP) (mPic 1) (p32) [Cleaved into: Mitochondrial phosphate carrier protein, N-terminally processed] 5 out of 5 NA "MIR1; Mir1p" NA MIR1 "TIM22 complex inserts proteins into inner membrane;TIM22 complex inserts proteins into inner membrane" 2.A.29.4.3 Mitochondrial phosphate carrier protein OS=Saccharomyces cerevisiae GN=MIR1 PE=1 SV=1 FALSE +YLR348C r_3961 phosphate[m] <=> phosphate[mm] Mitochondrial dicarboxylic transporter catalyzing the exchange of dicarboxylic acids like malate and succinate for inorganic phosphate. Required for growth on ethanol and acetate. {ECO:0000269|PubMed:10027973, ECO:0000269|PubMed:8831951, ECO:0000269|PubMed:9020177, ECO:0000269|PubMed:9559855}. MNXM9 none "Mitochondrial dicarboxylate carrier; integral membrane protein, catalyzes a dicarboxylate-phosphate exchange across the inner mitochondrial membrane, transports cytoplasmic dicarboxylates into the mitochondrial matrix" NA Mitochondrial dicarboxylate carrier NA Mitochondrial dicarboxylate transporter (DTP) (Dicarboxylate carrier 1) 5 out of 5 NA "DIC1; Dic1p" NA DIcarboxylate Carrier "Sulfate is exported to the cytosol in exchange for dicarboxylate;FA anion flip-flops to the opposite surface;FA anion flip-flops to the opposite surface;FA anion flip-flops to the opposite surface;FA anion flip-flops to the opposite surface;FA anion flip-flops to the opposite surface;FA anion diffuses laterally to UCP;FA anion diffuses laterally to UCP;FA anion diffuses laterally to UCP;FA anion diffuses laterally to UCP;FA anion diffuses laterally to UCP;The FA anion diffuses away laterally from UCP;The FA anion diffuses away laterally from UCP;The FA anion diffuses away laterally from UCP;The FA anion diffuses away laterally from UCP;The FA anion diffuses away laterally from UCP;Protons are translocated from the intermembrane space to the matrix;Protons are translocated from the intermembrane space to the matrix;Protons are translocated from the intermembrane space to the matrix;Protons are translocated from the intermembrane space to the matrix;Protons are translocated from the intermembrane space to the matrix;malate [mitochondrial matrix] + alpha-ketoglutarate [cytosol] <=> malate [cytosol] + alpha-ketoglutarate [mitochondrial matrix];malate [mitochondrial matrix] + orthophosphate [cytosol] <=> malate [cytosol] + orthophosphate [mitochondrial matrix];Exchange of alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane" 2.A.29.2.3 BELONGS TO THE MITOCHONDRIAL CARRIER FAMILY - Saccharomyces cerevisiae (Baker's yeast). FALSE +YJR152W r_4361 H+[e] + Gly-Met[e] <=> H+[c] + Gly-Met[c] Component of the allantoate transport system. MNXM55287 h+ "Allantoate permease; ureidosuccinate permease; also transports dipeptides, though with lower affinity than for allantoate and ureidosuccinate; expression is constitutive but sensitive to nitrogen catabolite repression" NA Allantoate permease NA Allantoate permease 4 out of 5 NA "DAL5, UREP1; allantoate permease" NA Degradation of Allantoin NA 2.A.1.14.4 Allantoate permease - Saccharomyces cerevisiae (Baker's yeast). FALSE +YKR093W r_4361 H+[e] + Gly-Met[e] <=> H+[c] + Gly-Met[c] Uptake of small peptides. MNXM55287 h+ "Integral membrane peptide transporter; mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p" NA Integral membrane peptide transporter NA Peptide transporter PTR2 (Peptide permease PTR2) 4 out of 5 NA "PTR2; Ptr2p" NA Peptide TRansport "Proton-coupled di- and tri-peptide cotransport;Proton-coupled di- and tri-peptide cotransport;Proton-coupled histidine and di-peptide cotransport;Proton-coupled histidine and di-peptide cotransport;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins" 2.A.17.2.2 PEPTIDE TRANSPORTER PTR2 (PEPTIDE PERMEASE PTR2) - Saccharomyces cerevisiae (Baker's yeast). FALSE +YJR152W r_4387 H+[e] + Ala-Asp[e] <=> H+[c] + Ala-Asp[c] Component of the allantoate transport system. MNXM40494 h+ "Allantoate permease; ureidosuccinate permease; also transports dipeptides, though with lower affinity than for allantoate and ureidosuccinate; expression is constitutive but sensitive to nitrogen catabolite repression" NA Allantoate permease NA Allantoate permease 4 out of 5 NA "DAL5, UREP1; allantoate permease" NA Degradation of Allantoin NA 2.A.1.14.4 Allantoate permease - Saccharomyces cerevisiae (Baker's yeast). FALSE +YKR093W r_4387 H+[e] + Ala-Asp[e] <=> H+[c] + Ala-Asp[c] Uptake of small peptides. MNXM40494 h+ "Integral membrane peptide transporter; mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p" NA Integral membrane peptide transporter NA Peptide transporter PTR2 (Peptide permease PTR2) 4 out of 5 NA "PTR2; Ptr2p" NA Peptide TRansport "Proton-coupled di- and tri-peptide cotransport;Proton-coupled di- and tri-peptide cotransport;Proton-coupled histidine and di-peptide cotransport;Proton-coupled histidine and di-peptide cotransport;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins" 2.A.17.2.2 PEPTIDE TRANSPORTER PTR2 (PEPTIDE PERMEASE PTR2) - Saccharomyces cerevisiae (Baker's yeast). FALSE +YDL245C r_4395 D-tagatose[e] <=> D-tagatose[c] Probable glucose transporter. MNXM92401 none "Putative transmembrane polyol transporter; supports growth on and uptake of mannitol, sorbitol and xylitol with moderate affinity when overexpressed in a strain deleted for hexose family members; minor hexose transport activity when overexpressed in a similar strain; similarity to hexose transporters; expression is induced by low levels of glucose and repressed by high levels of glucose" NA Putative transmembrane polyol transporter NA Hexose transporter HXT15 5 out of 5 NA "HXT15, HLT2; hexose transporter HXT15" NA HeXose Transporter NA 2.A.1.1.107 Hexose transporter HXT15 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HXT15 PE=1 SV=1 FALSE +YDR342C r_4395 D-tagatose[e] <=> D-tagatose[c] High-affinity glucose transporter. MNXM92401 none "High-affinity glucose transporter; member of the major facilitator superfamily, nearly identical to Hxt6p, expressed at high basal levels relative to other HXTs, expression repressed by high glucose levels; HXT7 has a paralog, HXT4, that arose from the whole genome duplication" NA High-affinity glucose transporter NA High-affinity hexose transporter HXT7 5 out of 5 NA "HXT7; hexose transporter HXT7" NA HeXose Transporter NA 2.A.1.1.31 High-affinity hexose transporter HXT6 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HXT7 PE=1 SV=1 FALSE +YDR343C r_4395 D-tagatose[e] <=> D-tagatose[c] High-affinity glucose transporter. MNXM92401 none "High-affinity glucose transporter; member of the major facilitator superfamily, nearly identical to Hxt7p, expressed at high basal levels relative to other HXTs, repression of expression by high glucose requires SNF3; HXT6 has a paralog, HXT1, that arose from the whole genome duplication" NA High-affinity glucose transporter NA High-affinity hexose transporter HXT6 4 out of 5 NA "HXT6; hexose transporter HXT6" NA HeXose Transporter NA NA NA FALSE +YDR345C r_4395 D-tagatose[e] <=> D-tagatose[c] Low-affinity glucose transporter. MNXM92401 none "Low affinity glucose transporter of the major facilitator superfamily; expression is induced in low or high glucose conditions; HXT3 has a paralog, HXT5, that arose from the whole genome duplication" NA Low affinity glucose transporter of the major facilitator superfamily NA Low-affinity glucose transporter HXT3 5 out of 5 NA "HXT3; hexose transporter HXT3" NA HeXose Transporter NA NA NA FALSE +YEL069C r_4395 D-tagatose[e] <=> D-tagatose[c] Probable glucose transporter. MNXM92401 none "Putative transmembrane polyol transporter; supports growth on and uptake of mannitol and sorbitol with moderate affinity when overexpressed in a strain deleted for hexose family members; minor hexose transport activity when overexpressed in a similar strain; induced by non-fermentable carbon sources; induced in low glucose, repressed in high glucose; HXT13 has a paralog, HXT17, that arose from a segmental duplication" NA Putative transmembrane polyol transporter NA Hexose transporter HXT13 4 out of 5 NA "HXT13, HLT1; hexose transporter HXT13" NA HeXose Transporter NA 2.A.1.1.110 Hexose transporter HXT13 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HXT13 PE=1 SV=1 FALSE +YFL011W r_4395 D-tagatose[e] <=> D-tagatose[c] Probable glucose transporter. MNXM92401 none "Putative hexose transporter; expressed at low levels and expression is repressed by glucose" NA Putative hexose transporter NA Hexose transporter HXT10 4 out of 5 NA "HXT10; hexose transporter HXT10" NA HeXose Transporter NA 2.A.1.1.5 Hexose transporter HXT10 - Saccharomyces cerevisiae (Baker's yeast). FALSE +YHR092C r_4395 D-tagatose[e] <=> D-tagatose[c] Low-affinity glucose transporter. Can also transport xylose. {ECO:0000269|PubMed:17180689}. MNXM92401 none "High-affinity glucose transporter; member of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose; HXT4 has a paralog, HXT7, that arose from the whole genome duplication" NA High-affinity glucose transporter NA Low-affinity glucose transporter HXT4 (Low-affinity glucose transporter LGT1) 5 out of 5 NA "HXT4, LGT1, RAG1; hexose transporter HXT4" NA HeXose Transporter NA 2.A.1.1.30 Low-affinity glucose transporter HXT4 (Low-affinity glucose transporter LGT1) - Saccharomyces cerevisiae (Baker's yeast). FALSE +YHR094C r_4395 D-tagatose[e] <=> D-tagatose[c] Low-affinity glucose transporter. HXT1 is as well involved in the transport of mannose. MNXM92401 none "Low-affinity glucose transporter of the major facilitator superfamily; expression is induced by Hxk2p in the presence of glucose and repressed by Rgt1p when glucose is limiting; HXT1 has a paralog, HXT6, what arose from the whole genome duplication" NA Low-affinity glucose transporter of the major facilitator superfamily NA Low-affinity glucose transporter HXT1 5 out of 5 NA "HXT1, HOR4; hexose transporter HXT1" NA HeXose Transporter NA 2.A.1.1.108 Low-affinity glucose transporter HXT1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HXT1 PE=1 SV=1 FALSE +YHR096C r_4395 D-tagatose[e] <=> D-tagatose[c] Probable glucose transporter. MNXM92401 none "Hexose transporter with moderate affinity for glucose; induced in the presence of non-fermentable carbon sources, induced by a decrease in growth rate, contains an extended N-terminal domain relative to other HXTs; HXT5 has a paralog, HXT3, that arose from the whole genome duplication" NA Hexose transporter with moderate affinity for glucose NA Probable glucose transporter HXT5 4 out of 5 NA "HXT5; hexose transporter HXT5" NA HeXose Transporter NA NA NA FALSE +YJL214W r_4395 D-tagatose[e] <=> D-tagatose[c] Probable glucose transporter. MNXM92401 none "Protein of unknown function with similarity to hexose transporters; expression is induced by low levels of glucose and repressed by high levels of glucose" NA Protein of unknown function with similarity to hexose transporters NA Hexose transporter HXT8 4 out of 5 NA "HXT8; hexose transporter HXT8" NA HeXose Transporter NA NA NA FALSE +YJL219W r_4395 D-tagatose[e] <=> D-tagatose[c] Probable glucose transporter. MNXM92401 none "Putative hexose transporter that is nearly identical to Hxt11p; has similarity to major facilitator superfamily (MFS) transporters, expression of HXT9 is regulated by transcription factors Pdr1p and Pdr3p" NA Putative hexose transporter that is nearly identical to Hxt11p NA Hexose transporter HXT9 4 out of 5 NA "HXT9; hexose transporter HXT9" NA HeXose Transporter NA NA NA FALSE +YJR158W r_4395 D-tagatose[e] <=> D-tagatose[c] Probable glucose transporter. MNXM92401 none "Putative transmembrane polyol transporter; supports growth on and uptake of sorbitol with moderate affinity and mannitol with lower affinity when overexpressed in a strain deleted for hexose family members; minor hexose transport activity when overexpressed in a similar strain; similarity to hexose transporters; expression is repressed by high levels of glucose" NA Putative transmembrane polyol transporter NA Hexose transporter HXT16 4 out of 5 NA "HXT16, HLT3; hexose transporter HXT16" NA HeXose Transporter NA NA NA FALSE +YMR011W r_4395 D-tagatose[e] <=> D-tagatose[c] High-affinity glucose transporter. Is only indispensable for growth on low glucose-containing media, because S.cerevisiae possesses other sugar transporters. MNXM92401 none "High-affinity glucose transporter of the major facilitator superfamily; expression is induced by low levels of glucose and repressed by high levels of glucose" NA High-affinity glucose transporter of the major facilitator superfamily NA High-affinity glucose transporter HXT2 4 out of 5 NA "HXT2; hexose transporter HXT2" NA HeXose Transporter NA 2.A.1.1.111 High-affinity glucose transporter HXT2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HXT2 PE=1 SV=1 FALSE +YNR072W r_4395 D-tagatose[e] <=> D-tagatose[c] Probable glucose transporter. MNXM92401 none "Putative transmembrane polyol transporter; supports growth on and uptake of mannitol and sorbitol with moderate affinity when overexpressed in a strain deleted for hexose family members; minor hexose transport activity when overexpressed in a similar strain; induced by raffinose and galactose at pH 7.7 versus pH 4.7, repressed by high levels of glucose; HXT17 has a paralog, HXT13, that arose from a segmental duplication" NA Putative transmembrane polyol transporter NA Hexose transporter HXT17 4 out of 5 NA "HXT17, HLT4; hexose transporter HXT17" NA HeXose Transporter NA NA NA FALSE +YOL156W r_4395 D-tagatose[e] <=> D-tagatose[c] Probable glucose transporter. MNXM92401 none "Hexose transporter; capable of transporting a broad range of substrates including: glucose, fructose, mannose and galactose; polyol transporter that supports the growth on and uptake of xylitol with low affinity when overexpressed in a strain deleted for hexose family members; nearly identical in sequence to Hxt9p; has similarity to major facilitator superfamily (MFS) transporters; involved in pleiotropic drug resistance" NA Hexose transporter NA Hexose transporter HXT11 (Low-affinity glucose transporter LGT3) 4 out of 5 NA "HXT11, LGT3; hexose transporter HXT11" NA HeXose Transporter NA 2.A.1.1.105 Hexose transporter HXT11 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HXT11 PE=1 SV=1 FALSE +YJR152W r_4398 H+[e] + Ala-Gln[e] <=> H+[c] + Ala-Gln[c] Component of the allantoate transport system. MNXM40495 h+ "Allantoate permease; ureidosuccinate permease; also transports dipeptides, though with lower affinity than for allantoate and ureidosuccinate; expression is constitutive but sensitive to nitrogen catabolite repression" NA Allantoate permease NA Allantoate permease 4 out of 5 NA "DAL5, UREP1; allantoate permease" NA Degradation of Allantoin NA 2.A.1.14.4 Allantoate permease - Saccharomyces cerevisiae (Baker's yeast). FALSE +YKR093W r_4398 H+[e] + Ala-Gln[e] <=> H+[c] + Ala-Gln[c] Uptake of small peptides. MNXM40495 h+ "Integral membrane peptide transporter; mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p" NA Integral membrane peptide transporter NA Peptide transporter PTR2 (Peptide permease PTR2) 4 out of 5 NA "PTR2; Ptr2p" NA Peptide TRansport "Proton-coupled di- and tri-peptide cotransport;Proton-coupled di- and tri-peptide cotransport;Proton-coupled histidine and di-peptide cotransport;Proton-coupled histidine and di-peptide cotransport;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins" 2.A.17.2.2 PEPTIDE TRANSPORTER PTR2 (PEPTIDE PERMEASE PTR2) - Saccharomyces cerevisiae (Baker's yeast). FALSE +YJR152W r_4402 H+[e] + Ala-Thr[e] <=> H+[c] + Ala-Thr[c] Component of the allantoate transport system. MNXM40497 h+ "Allantoate permease; ureidosuccinate permease; also transports dipeptides, though with lower affinity than for allantoate and ureidosuccinate; expression is constitutive but sensitive to nitrogen catabolite repression" NA Allantoate permease NA Allantoate permease 4 out of 5 NA "DAL5, UREP1; allantoate permease" NA Degradation of Allantoin NA 2.A.1.14.4 Allantoate permease - Saccharomyces cerevisiae (Baker's yeast). FALSE +YKR093W r_4402 H+[e] + Ala-Thr[e] <=> H+[c] + Ala-Thr[c] Uptake of small peptides. MNXM40497 h+ "Integral membrane peptide transporter; mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p" NA Integral membrane peptide transporter NA Peptide transporter PTR2 (Peptide permease PTR2) 4 out of 5 NA "PTR2; Ptr2p" NA Peptide TRansport "Proton-coupled di- and tri-peptide cotransport;Proton-coupled di- and tri-peptide cotransport;Proton-coupled histidine and di-peptide cotransport;Proton-coupled histidine and di-peptide cotransport;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins" 2.A.17.2.2 PEPTIDE TRANSPORTER PTR2 (PEPTIDE PERMEASE PTR2) - Saccharomyces cerevisiae (Baker's yeast). FALSE +YJR152W r_4404 H+[e] + Gly-Asn[e] <=> H+[c] + Gly-Asn[c] Component of the allantoate transport system. MNXM55268 h+ "Allantoate permease; ureidosuccinate permease; also transports dipeptides, though with lower affinity than for allantoate and ureidosuccinate; expression is constitutive but sensitive to nitrogen catabolite repression" NA Allantoate permease NA Allantoate permease 4 out of 5 NA "DAL5, UREP1; allantoate permease" NA Degradation of Allantoin NA 2.A.1.14.4 Allantoate permease - Saccharomyces cerevisiae (Baker's yeast). FALSE +YKR093W r_4404 H+[e] + Gly-Asn[e] <=> H+[c] + Gly-Asn[c] Uptake of small peptides. MNXM55268 h+ "Integral membrane peptide transporter; mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p" NA Integral membrane peptide transporter NA Peptide transporter PTR2 (Peptide permease PTR2) 4 out of 5 NA "PTR2; Ptr2p" NA Peptide TRansport "Proton-coupled di- and tri-peptide cotransport;Proton-coupled di- and tri-peptide cotransport;Proton-coupled histidine and di-peptide cotransport;Proton-coupled histidine and di-peptide cotransport;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins" 2.A.17.2.2 PEPTIDE TRANSPORTER PTR2 (PEPTIDE PERMEASE PTR2) - Saccharomyces cerevisiae (Baker's yeast). FALSE +YJR152W r_4408 H+[e] + Ala-Glu[e] <=> H+[c] + Ala-Glu[c] Component of the allantoate transport system. MNXM4026 h+ "Allantoate permease; ureidosuccinate permease; also transports dipeptides, though with lower affinity than for allantoate and ureidosuccinate; expression is constitutive but sensitive to nitrogen catabolite repression" NA Allantoate permease NA Allantoate permease 4 out of 5 NA "DAL5, UREP1; allantoate permease" NA Degradation of Allantoin NA 2.A.1.14.4 Allantoate permease - Saccharomyces cerevisiae (Baker's yeast). FALSE +YKR093W r_4408 H+[e] + Ala-Glu[e] <=> H+[c] + Ala-Glu[c] Uptake of small peptides. MNXM4026 h+ "Integral membrane peptide transporter; mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p" NA Integral membrane peptide transporter NA Peptide transporter PTR2 (Peptide permease PTR2) 4 out of 5 NA "PTR2; Ptr2p" NA Peptide TRansport "Proton-coupled di- and tri-peptide cotransport;Proton-coupled di- and tri-peptide cotransport;Proton-coupled histidine and di-peptide cotransport;Proton-coupled histidine and di-peptide cotransport;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins" 2.A.17.2.2 PEPTIDE TRANSPORTER PTR2 (PEPTIDE PERMEASE PTR2) - Saccharomyces cerevisiae (Baker's yeast). FALSE +YJR152W r_4424 H+[e] + Gly-Gln[e] <=> H+[c] + Gly-Gln[c] Component of the allantoate transport system. MNXM55276 h+ "Allantoate permease; ureidosuccinate permease; also transports dipeptides, though with lower affinity than for allantoate and ureidosuccinate; expression is constitutive but sensitive to nitrogen catabolite repression" NA Allantoate permease NA Allantoate permease 4 out of 5 NA "DAL5, UREP1; allantoate permease" NA Degradation of Allantoin NA 2.A.1.14.4 Allantoate permease - Saccharomyces cerevisiae (Baker's yeast). FALSE +YKR093W r_4424 H+[e] + Gly-Gln[e] <=> H+[c] + Gly-Gln[c] Uptake of small peptides. MNXM55276 h+ "Integral membrane peptide transporter; mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p" NA Integral membrane peptide transporter NA Peptide transporter PTR2 (Peptide permease PTR2) 4 out of 5 NA "PTR2; Ptr2p" NA Peptide TRansport "Proton-coupled di- and tri-peptide cotransport;Proton-coupled di- and tri-peptide cotransport;Proton-coupled histidine and di-peptide cotransport;Proton-coupled histidine and di-peptide cotransport;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins" 2.A.17.2.2 PEPTIDE TRANSPORTER PTR2 (PEPTIDE PERMEASE PTR2) - Saccharomyces cerevisiae (Baker's yeast). FALSE +YJR152W r_4429 H+[e] + Ala-His[e] <=> H+[c] + Ala-His[c] Component of the allantoate transport system. MNXM40496 h+ "Allantoate permease; ureidosuccinate permease; also transports dipeptides, though with lower affinity than for allantoate and ureidosuccinate; expression is constitutive but sensitive to nitrogen catabolite repression" NA Allantoate permease NA Allantoate permease 4 out of 5 NA "DAL5, UREP1; allantoate permease" NA Degradation of Allantoin NA 2.A.1.14.4 Allantoate permease - Saccharomyces cerevisiae (Baker's yeast). FALSE +YKR093W r_4429 H+[e] + Ala-His[e] <=> H+[c] + Ala-His[c] Uptake of small peptides. MNXM40496 h+ "Integral membrane peptide transporter; mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p" NA Integral membrane peptide transporter NA Peptide transporter PTR2 (Peptide permease PTR2) 4 out of 5 NA "PTR2; Ptr2p" NA Peptide TRansport "Proton-coupled di- and tri-peptide cotransport;Proton-coupled di- and tri-peptide cotransport;Proton-coupled histidine and di-peptide cotransport;Proton-coupled histidine and di-peptide cotransport;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins" 2.A.17.2.2 PEPTIDE TRANSPORTER PTR2 (PEPTIDE PERMEASE PTR2) - Saccharomyces cerevisiae (Baker's yeast). FALSE +YJR152W r_4437 H+[e] + Gly-Glu[e] <=> H+[c] + Gly-Glu[c] Component of the allantoate transport system. MNXM55454 h+ "Allantoate permease; ureidosuccinate permease; also transports dipeptides, though with lower affinity than for allantoate and ureidosuccinate; expression is constitutive but sensitive to nitrogen catabolite repression" NA Allantoate permease NA Allantoate permease 4 out of 5 NA "DAL5, UREP1; allantoate permease" NA Degradation of Allantoin NA 2.A.1.14.4 Allantoate permease - Saccharomyces cerevisiae (Baker's yeast). FALSE +YKR093W r_4437 H+[e] + Gly-Glu[e] <=> H+[c] + Gly-Glu[c] Uptake of small peptides. MNXM55454 h+ "Integral membrane peptide transporter; mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p" NA Integral membrane peptide transporter NA Peptide transporter PTR2 (Peptide permease PTR2) 4 out of 5 NA "PTR2; Ptr2p" NA Peptide TRansport "Proton-coupled di- and tri-peptide cotransport;Proton-coupled di- and tri-peptide cotransport;Proton-coupled histidine and di-peptide cotransport;Proton-coupled histidine and di-peptide cotransport;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins" 2.A.17.2.2 PEPTIDE TRANSPORTER PTR2 (PEPTIDE PERMEASE PTR2) - Saccharomyces cerevisiae (Baker's yeast). FALSE +YJR152W r_4448 H+[e] + Met-Ala[e] <=> H+[c] + Met-Ala[c] Component of the allantoate transport system. MNXM61647 h+ "Allantoate permease; ureidosuccinate permease; also transports dipeptides, though with lower affinity than for allantoate and ureidosuccinate; expression is constitutive but sensitive to nitrogen catabolite repression" NA Allantoate permease NA Allantoate permease 4 out of 5 NA "DAL5, UREP1; allantoate permease" NA Degradation of Allantoin NA 2.A.1.14.4 Allantoate permease - Saccharomyces cerevisiae (Baker's yeast). FALSE +YKR093W r_4448 H+[e] + Met-Ala[e] <=> H+[c] + Met-Ala[c] Uptake of small peptides. MNXM61647 h+ "Integral membrane peptide transporter; mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p" NA Integral membrane peptide transporter NA Peptide transporter PTR2 (Peptide permease PTR2) 4 out of 5 NA "PTR2; Ptr2p" NA Peptide TRansport "Proton-coupled di- and tri-peptide cotransport;Proton-coupled di- and tri-peptide cotransport;Proton-coupled histidine and di-peptide cotransport;Proton-coupled histidine and di-peptide cotransport;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins" 2.A.17.2.2 PEPTIDE TRANSPORTER PTR2 (PEPTIDE PERMEASE PTR2) - Saccharomyces cerevisiae (Baker's yeast). FALSE +YDR093W r_4457 H+[e] + O-phosphoethanolamine[e] <=> H+[c] + O-phosphoethanolamine[c] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids. Required for protein transport from Golgi to vacuoles. {ECO:0000269|PubMed:12221123}. MNXM187 h+ "Aminophospholipid translocase (flippase); type 4 P-type ATPase; involved in phospholipid translocation, contributing to endocytosis, protein transport, and cellular polarization; localizes primarily to the plasma membrane; localizes to the shmoo tip where it has a redundant role in the cellular response to mating pheromone; DNF2 has a paralog, DNF1, that arose from the whole genome duplication" 3.6.3.1 Aminophospholipid translocase (flippase) 3.6.3.1 Phospholipid-transporting ATPase DNF2 (EC 3.6.3.1) (Flippase DNF2) 5 out of 5 ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). "DNF2; aminophospholipid-translocating P4-type ATPase DNF2" 3.6.3.1 Drs2 Neo1 Family "P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane;P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane" 3.A.3.8.5 Probable phospholipid-transporting ATPase DNF2 (EC 3.6.3.1) - Saccharomyces cerevisiae (Baker's yeast) FALSE +YDR342C r_4468 2-deoxy-D-ribose[e] <=> 2-deoxy-D-ribose[c] High-affinity glucose transporter. MNXM2474 none "High-affinity glucose transporter; member of the major facilitator superfamily, nearly identical to Hxt6p, expressed at high basal levels relative to other HXTs, expression repressed by high glucose levels; HXT7 has a paralog, HXT4, that arose from the whole genome duplication" NA High-affinity glucose transporter NA High-affinity hexose transporter HXT7 5 out of 5 NA "HXT7; hexose transporter HXT7" NA HeXose Transporter NA 2.A.1.1.31 High-affinity hexose transporter HXT6 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HXT7 PE=1 SV=1 FALSE +YHR092C r_4468 2-deoxy-D-ribose[e] <=> 2-deoxy-D-ribose[c] Low-affinity glucose transporter. Can also transport xylose. {ECO:0000269|PubMed:17180689}. MNXM2474 none "High-affinity glucose transporter; member of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose; HXT4 has a paralog, HXT7, that arose from the whole genome duplication" NA High-affinity glucose transporter NA Low-affinity glucose transporter HXT4 (Low-affinity glucose transporter LGT1) 5 out of 5 NA "HXT4, LGT1, RAG1; hexose transporter HXT4" NA HeXose Transporter NA 2.A.1.1.30 Low-affinity glucose transporter HXT4 (Low-affinity glucose transporter LGT1) - Saccharomyces cerevisiae (Baker's yeast). FALSE +YKR039W r_4469 H+[e] + L-citrulline[e] <=> H+[c] + L-citrulline[c] General amino-acid permease involved in the uptake of all the naturally occurring L-amino-acids, related compounds such as ornithine and citrulline, some D-amino acids, toxic amino acid analogs such as azetidine-2-carboxylate, and the polyamines putrescine and spermidine (PubMed:5474888, PubMed:10467005, PubMed:10373490, PubMed:10953083, PubMed:14968425, PubMed:15707981). Senses its transport substrates to set an appropriate level of transporter activity at the cell surface (PubMed:21471002). Required for FLO11 expression and invasive growth (PubMed:22844449). {ECO:0000269|PubMed:10373490, ECO:0000269|PubMed:10467005, ECO:0000269|PubMed:10953083, ECO:0000269|PubMed:14968425, ECO:0000269|PubMed:15707981, ECO:0000269|PubMed:21471002, ECO:0000269|PubMed:22844449, ECO:0000269|PubMed:5474888}. MNXM211 h+ "General amino acid permease; Gap1p senses the presence of amino acid substrates to regulate localization to the plasma membrane when needed; essential for invasive growth" NA General amino acid permease NA General amino-acid permease GAP1 5 out of 5 NA "GAP1; amino acid permease GAP1" NA General Amino acid Permease NA 2.A.3.10.2 General amino-acid permease GAP1 - Saccharomyces cerevisiae (Baker's yeast). FALSE +YJR152W r_4471 H+[e] + Ala-Leu[e] <=> H+[c] + Ala-Leu[c] Component of the allantoate transport system. MNXM15786 h+ "Allantoate permease; ureidosuccinate permease; also transports dipeptides, though with lower affinity than for allantoate and ureidosuccinate; expression is constitutive but sensitive to nitrogen catabolite repression" NA Allantoate permease NA Allantoate permease 4 out of 5 NA "DAL5, UREP1; allantoate permease" NA Degradation of Allantoin NA 2.A.1.14.4 Allantoate permease - Saccharomyces cerevisiae (Baker's yeast). FALSE +YKR093W r_4471 H+[e] + Ala-Leu[e] <=> H+[c] + Ala-Leu[c] Uptake of small peptides. MNXM15786 h+ "Integral membrane peptide transporter; mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p" NA Integral membrane peptide transporter NA Peptide transporter PTR2 (Peptide permease PTR2) 4 out of 5 NA "PTR2; Ptr2p" NA Peptide TRansport "Proton-coupled di- and tri-peptide cotransport;Proton-coupled di- and tri-peptide cotransport;Proton-coupled histidine and di-peptide cotransport;Proton-coupled histidine and di-peptide cotransport;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins" 2.A.17.2.2 PEPTIDE TRANSPORTER PTR2 (PEPTIDE PERMEASE PTR2) - Saccharomyces cerevisiae (Baker's yeast). FALSE +YJR152W r_4473 H+[e] + Ala-Gly[e] <=> H+[c] + Ala-Gly[c] Component of the allantoate transport system. MNXM15783 h+ "Allantoate permease; ureidosuccinate permease; also transports dipeptides, though with lower affinity than for allantoate and ureidosuccinate; expression is constitutive but sensitive to nitrogen catabolite repression" NA Allantoate permease NA Allantoate permease 4 out of 5 NA "DAL5, UREP1; allantoate permease" NA Degradation of Allantoin NA 2.A.1.14.4 Allantoate permease - Saccharomyces cerevisiae (Baker's yeast). FALSE +YKR093W r_4473 H+[e] + Ala-Gly[e] <=> H+[c] + Ala-Gly[c] Uptake of small peptides. MNXM15783 h+ "Integral membrane peptide transporter; mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p" NA Integral membrane peptide transporter NA Peptide transporter PTR2 (Peptide permease PTR2) 4 out of 5 NA "PTR2; Ptr2p" NA Peptide TRansport "Proton-coupled di- and tri-peptide cotransport;Proton-coupled di- and tri-peptide cotransport;Proton-coupled histidine and di-peptide cotransport;Proton-coupled histidine and di-peptide cotransport;Exocytosis of specific granule membrane proteins;Exocytosis of specific granule membrane proteins" 2.A.17.2.2 PEPTIDE TRANSPORTER PTR2 (PEPTIDE PERMEASE PTR2) - Saccharomyces cerevisiae (Baker's yeast). FALSE +YNL065W r_4493 acetoacetate[e] <=> acetoacetate[c] Probable transporter that confers resistance to short-chain monocarboxylic acids and quinidine. {ECO:0000269|PubMed:11922628}. MNXM154 none "Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; confers resistance to short-chain monocarboxylic acids and quinidine; involved in the excretion of excess amino acids; AQR1 has a paralog, QDR1, that arose from the whole genome duplication; relocalizes from plasma membrane to cytoplasm upon DNA replication stress" NA Plasma membrane transporter of the major facilitator superfamily NA Probable transporter AQR1 4 out of 5 NA "AQR1; Aqr1p" NA Acids Quinidine Resistance NA 2.A.1.2.36 Probable transporter AQR1 - Saccharomyces cerevisiae (Baker's yeast). FALSE \ No newline at end of file diff --git a/ComplementaryData/modelCuration/TransRxnNewGPR.tsv b/ComplementaryData/modelCuration/TransRxnNewGPR.tsv new file mode 100644 index 00000000..3e05d1c4 --- /dev/null +++ b/ComplementaryData/modelCuration/TransRxnNewGPR.tsv @@ -0,0 +1,102 @@ +rxnID new_gpr +r_4468 ( YDR342C or YHR092C ) +r_1735 YBL042C +r_4493 YNL065W +r_4387 ( YJR152W or YKR093W ) +r_4398 ( YJR152W or YKR093W ) +r_4408 ( YJR152W or YKR093W ) +r_4473 ( YJR152W or YKR093W ) +r_4429 ( YJR152W or YKR093W ) +r_4471 ( YJR152W or YKR093W ) +r_4402 ( YJR152W or YKR093W ) +r_2190 YNL065W +r_1707 ( YDR342C or YHR092C ) +r_1717 ( YDL245C or YEL069C or YJR158W or YNR072W ) +r_2041 ( YDR342C or YHR092C ) +r_4395 ( YDL245C or YDR342C or YDR343C or YDR345C or YEL069C or YFL011W or YHR092C or YHR094C or YHR096C or YJL214W or YJL219W or YJR158W or YMR011W or YNR072W or YOL156W ) +r_1719 YHR092C +r_1149 YGL077C +r_1795 YNL065W +r_1990 YJL212C +r_4404 ( YJR152W or YKR093W ) +r_4424 ( YJR152W or YKR093W ) +r_4437 ( YJR152W or YKR093W ) +r_4361 ( YJR152W or YKR093W ) +r_1816 YNL065W +r_2191 YNL065W +r_1877 ( YDR342C or YHR092C ) +r_4469 YKR039W +r_1908 ( YDL245C or YEL069C or YJR158W or YNR072W ) +r_1910 ( YDL245C or YDR342C or YDR343C or YDR345C or YEL069C or YFL011W or YHR092C or YHR094C or YHR096C or YJL214W or YJL219W or YJR158W or YMR011W or YNR072W or YOL156W ) +r_4448 ( YJR152W or YKR093W ) +r_4457 YDR093W +r_2040 YOR306C +r_2105 ( YDL245C or YLL043W ) +r_1882 YOR100C +r_3607 YCR098C +r_1574 YKL120W +r_1642 YPR011C +r_1684 ( YGL077C or YOR161C ) +r_3959 YBR192W +r_3680 YHR002W +r_3960 YBR192W +r_1760 ( YIL013C or YOR011W ) +r_1803 YGL225W +r_2094 ( YLL052C or YPR192W ) +r_3526 ( YLL052C or YPR192W ) +r_3604 ( YLL052C or YLL053C or YPR192W ) +r_1179 ( YJL133W or YKR052C ) +r_1657 YBR147W +r_1658 YDR508C +r_1811 YPR058W +r_1837 YBR147W +r_1919 YBR147W +r_1935 YDR508C +r_1907 YKR039W +r_2045 YDR508C +r_3545 YKR039W +r_2072 YDR508C +r_1771 ( YKL188C and YPL147W ) +r_1772 ( YKL188C and YPL147W ) +r_1976 YOR100C +r_2231 ( YKL188C and YPL147W ) +r_1774 ( YKL188C and YPL147W ) +r_3961 ( YER053C or YJR077C or YLR348C ) +r_2008 YNR013C +r_3605 ( YCR037C or YJL198W or YML123C ) +r_3649 YNR013C +r_3893 YIL048W +r_3813 ( YIL048W or YMR162C ) +r_3897 YIL048W +r_3817 ( YIL048W or YMR162C ) +r_3894 YIL048W +r_3814 ( YIL048W or YMR162C ) +r_3898 YIL048W +r_3818 ( YIL048W or YMR162C ) +r_3895 YIL048W +r_3815 ( YIL048W or YMR162C ) +r_3899 YIL048W +r_3819 ( YIL048W or YMR162C ) +r_3896 YIL048W +r_3816 ( YIL048W or YMR162C ) +r_3900 YIL048W +r_3820 ( YIL048W or YMR162C ) +r_3821 YAL026C +r_3885 YAL026C +r_3825 YAL026C +r_3889 YAL026C +r_3822 YAL026C +r_3886 YAL026C +r_3826 YAL026C +r_3890 YAL026C +r_3823 YAL026C +r_3887 YAL026C +r_3827 YAL026C +r_3891 YAL026C +r_3824 YAL026C +r_3888 YAL026C +r_3828 YAL026C +r_3892 YAL026C +r_3606 YCR098C +r_1236 ( YKL188C and YPL147W ) +r_2107 ( YIL013C or YOR011W ) diff --git a/ComplementaryScripts/missingFields/addConfidenceScores.m b/ComplementaryScripts/missingFields/addConfidenceScores.m index 62455bf1..76ca9d3c 100644 --- a/ComplementaryScripts/missingFields/addConfidenceScores.m +++ b/ComplementaryScripts/missingFields/addConfidenceScores.m @@ -23,9 +23,10 @@ end else rxnName = model.rxnNames{i}; + rxnNotes = model.rxnNotes{i}; if contains(rxnName,'exchange') rxnConfidenceScores(i) = NaN; - elseif contains(rxnName,'SLIME rxn') || contains(rxnName,'pseudoreaction') + elseif contains(rxnName,'SLIME rxn') || contains(rxnName,'pseudoreaction') || contains(rxnNotes,'Biolog update') || contains(rxnNotes,'BiomassUpdate') rxnConfidenceScores(i) = 1; else metNames = model.metNames(model.S(:,i) ~= 0); diff --git a/ComplementaryScripts/modelCuration/addTransNewGPR.m b/ComplementaryScripts/modelCuration/addTransNewGPR.m new file mode 100644 index 00000000..8158069c --- /dev/null +++ b/ComplementaryScripts/modelCuration/addTransNewGPR.m @@ -0,0 +1,51 @@ +%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% +% addTransNewGPR +% Add changes from the database new anootation for new genes + manual curation on those changes +% Input: model, databasenewGPR.tsv,SGDgeneNames.tsv. +% As for the reference of new GPR, please find detailed information in: +% ComplementaryData/databases/DBnewGeneAnnotation.tsv +% NOTE: changeGeneAssociation.m is a function from cobra +% +% Feiran Li & Hongzhong Lu +%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% + +% Load model +cd .. +model = loadYeastModel; + +% Change GPR relations +fid = fopen('../ComplementaryData/modelCuration/TransRxnNewGPR.tsv'); +changegpr = textscan(fid,'%s %s','Delimiter','\t','HeaderLines',1); +newGPR.ID = changegpr{1}; +newGPR.GPR = changegpr{2}; +fclose(fid); +for i = 1:length(newGPR.ID) + rxnIndex = find(strcmp(model.rxns, newGPR.ID(i))); + model = changeGeneAssociation(model, model.rxns{rxnIndex}, newGPR.GPR{i}); +end + +% Delete unused genes (if any) +model = removeUnusedGenes(model); + +% Add gene standard name for new genes +fid = fopen('../ComplementaryData/databases/SGDgeneNames.tsv'); +yeast_gene_annotation = textscan(fid,'%s %s','Delimiter','\t','HeaderLines',1); +fclose(fid); +for i = 1: length(model.genes) + geneIndex = strcmp(yeast_gene_annotation{1}, model.genes{i}); + if sum(geneIndex) == 1 && ~isempty(yeast_gene_annotation{2}{geneIndex}) + model.geneNames{i} = yeast_gene_annotation{2}{geneIndex}; + else + model.geneNames{i} = model.genes{i}; + end +end + +% Add protein name for genes +for i = 1:length(model.genes) + model.proteins{i} = strcat('COBRAProtein',num2str(i)); +end + +% Save model: +model = rmfield(model,'grRules'); +saveYeastModel(model) +cd modelCuration diff --git a/ModelFiles/dependencies.txt b/ModelFiles/dependencies.txt index a9ac44bb..94f39789 100644 --- a/ModelFiles/dependencies.txt +++ b/ModelFiles/dependencies.txt @@ -1,4 +1,4 @@ -MATLAB 9.5.0.944444 (R2018b) +MATLAB 9.1.0.441655 (R2016b) libSBML 5.17.0 RAVEN_toolbox 2.1.0 COBRA_toolbox 3.0.3 diff --git a/ModelFiles/txt/yeastGEM.txt b/ModelFiles/txt/yeastGEM.txt index 33cb9e2d..0dc07e0e 100644 --- a/ModelFiles/txt/yeastGEM.txt +++ b/ModelFiles/txt/yeastGEM.txt @@ -2056,7 +2056,7 @@ r_1139 s_0572[e] + s_0796[e] -> s_0571[c] + s_0794[c] ( YDL245C or YDR342C or r_1146 s_0659[e] <=> s_0657[c] ( YIL013C or YOR011W ) -1000.00 1000.00 0.00 r_1147 s_0668[e] <=> s_0666[c] ( YIL013C or YOR011W ) -1000.00 1000.00 0.00 r_1148 s_0665[ce] <=> s_0666[c] ( YIL013C or YOR011W ) -1000.00 1000.00 0.00 -r_1149 s_0684[e] <=> s_0683[c] -1000.00 1000.00 0.00 +r_1149 s_0684[e] <=> s_0683[c] YGL077C -1000.00 1000.00 0.00 r_1151 s_0690[m] -> s_0689[c] YIL134W 0.00 1000.00 0.00 r_1161 s_0702[e] <=> s_0700[c] ( YIL013C or YOR011W ) -1000.00 1000.00 0.00 r_1162 s_0699[ce] <=> s_0700[c] ( YIL013C or YOR011W ) -1000.00 1000.00 0.00 @@ -2075,7 +2075,7 @@ r_1175 s_0741[m] + s_0785[c] + s_0794[c] -> s_0739[c] + s_0786[m] + s_0799[m] r_1176 s_0788[e] + s_0796[e] <=> s_0787[c] + s_0794[c] ( YER056C or YER060W or YER060W-A or YGL186C ) -1000.00 1000.00 0.00 r_1177 s_0796[e] + s_1154[e] -> s_0794[c] + s_1153[c] ( YDR497C or YOL103W ) 0.00 1000.00 0.00 r_1178 s_0925[e] -> s_0924[c] ( YMR319C or YMR058W ) 0.00 1000.00 0.00 -r_1179 s_0924[c] -> s_0926[m] 0.00 1000.00 0.00 +r_1179 s_0924[c] -> s_0926[m] ( YJL133W or YKR052C ) 0.00 1000.00 0.00 r_1180 s_0927[c] -> s_0928[e] 0.00 1000.00 0.00 r_1181 s_0935[c] -> s_0936[e] 0.00 1000.00 0.00 r_1182 s_0943[c] <=> s_0945[m] -1000.00 1000.00 0.00 @@ -2130,7 +2130,7 @@ r_1230 s_0585[m] + s_1198[c] -> s_0584[c] + s_1200[m] YIL006W 0.00 1000.00 r_1231 s_0424[m] + s_1198[c] -> s_0423[c] + s_1200[m] YIL006W 0.00 1000.00 0.00 r_1232 s_0616[m] + s_1198[c] -> s_0615[c] + s_1200[m] YIL006W 0.00 1000.00 0.00 r_1235 s_1220[e] <=> s_1219[c] YGR260W -1000.00 1000.00 0.00 -r_1236 s_1449[c] <=> s_1451[p] -1000.00 1000.00 0.00 +r_1236 s_1449[c] <=> s_1451[p] ( YKL188C and YPL147W ) -1000.00 1000.00 0.00 r_1237 s_0794[c] + s_1268[m] -> s_0799[m] + s_1266[c] YOR130C 0.00 1000.00 0.00 r_1238 s_0796[e] + s_1267[e] <=> s_0794[c] + s_1266[c] ( YEL063C or YKR039W ) -1000.00 1000.00 0.00 r_1239 s_0794[c] + s_1271[c] -> s_0799[m] + s_1273[m] YKL120W 0.00 1000.00 0.00 @@ -2169,7 +2169,7 @@ r_1275 s_0716[m] + s_0794[c] + s_1547[m] + s_1559[c] -> s_0714[c] + s_0799[m] + r_1276 2 s_0794[c] + s_1547[m] + s_1559[c] -> 2 s_0799[m] + s_1545[c] + s_1560[m] YBR192W 0.00 1000.00 0.00 r_1277 s_0805[e] <=> s_0803[c] ( YLL052C or YPR192W ) -1000.00 1000.00 0.00 r_1278 s_1571[e] <=> s_1568[ce] ( YIL013C or YOR011W ) -1000.00 1000.00 0.00 -r_1657 s_0794[c] + s_0965[c] -> s_0799[m] + s_0967[m] 0.00 1000.00 0.00 +r_1657 s_0794[c] + s_0965[c] -> s_0799[m] + s_0967[m] YBR147W 0.00 1000.00 0.00 r_2034 s_0794[c] + s_1399[c] -> s_0799[m] + s_1401[m] (( YGL080W and YGR243W ) or ( YGL080W and YHR162W )) 0.00 1000.00 0.00 r_2079 s_0794[c] + s_1520[c] <=> s_0796[e] + s_1521[e] YGR289C -1000.00 1000.00 0.00 r_2132 s_0066[c] + s_0182[m] -> s_0068[m] + s_0180[c] ( YOR222W or YPL134C ) 0.00 1000.00 0.00 @@ -2465,7 +2465,7 @@ r_1567 s_0349[c] <=> s_0350[m] -1000.00 1000.00 0.00 r_1568 s_0149[c] <=> s_0150[m] -1000.00 1000.00 0.00 r_1572 s_0163[e] -> 0.00 1000.00 0.00 r_1573 s_0162[c] <=> s_0163[e] -1000.00 1000.00 0.00 -r_1574 s_0162[c] <=> s_0164[m] -1000.00 1000.00 0.00 +r_1574 s_0162[c] <=> s_0164[m] YKL120W -1000.00 1000.00 0.00 r_1575 s_0169[c] <=> s_0170[e] -1000.00 1000.00 0.00 r_1576 s_0169[c] <=> s_0171[m] -1000.00 1000.00 0.00 r_1577 s_0167[e] -> 0.00 1000.00 0.00 @@ -2524,7 +2524,7 @@ r_1638 s_1237[p] -> s_1235[c] 0.00 1000.00 0.00 r_1639 s_0384[e] -> 0.00 1000.00 0.00 r_1640 s_0383[c] <=> s_0385[m] -1000.00 1000.00 0.00 r_1641 s_0391[e] -> 0.00 1000.00 0.00 -r_1642 s_0390[c] <=> s_0392[m] -1000.00 1000.00 0.00 +r_1642 s_0390[c] <=> s_0392[m] YPR011C -1000.00 1000.00 0.00 r_1643 s_0387[e] -> 0.00 1000.00 0.00 r_1644 s_0394[c] <=> s_0398[n] -1000.00 1000.00 0.00 r_1645 s_0394[c] <=> s_0395[er] -1000.00 1000.00 0.00 @@ -2536,7 +2536,7 @@ r_1651 s_0413[e] -> 0.00 1000.00 0.00 r_1652 s_0067[e] + s_0180[c] <=> s_0066[c] + s_0181[e] -1000.00 1000.00 0.00 r_1654 s_0420[e] <=> -1000.00 1000.00 0.00 r_1656 s_0425[n] <=> s_0423[c] -1000.00 1000.00 0.00 -r_1658 s_0969[c] -> s_0971[m] 0.00 1000.00 0.00 +r_1658 s_0969[c] -> s_0971[m] YDR508C 0.00 1000.00 0.00 r_1659 s_0973[c] + s_0995[p] <=> s_0976[p] + s_0991[c] -1000.00 1000.00 0.00 r_1660 s_0434[c] <=> s_0438[n] -1000.00 1000.00 0.00 r_1661 s_0434[c] <=> s_0435[er] -1000.00 1000.00 0.00 @@ -2559,7 +2559,7 @@ r_1680 s_0485[g] <=> s_0484[er] -1000.00 1000.00 0.00 r_1681 s_0503[g] <=> s_0502[er] -1000.00 1000.00 0.00 r_1682 s_1275[c] + s_1416[c] + s_1569[c] -> s_0662[c] + s_0794[c] + 2 s_0803[c] + s_1413[c] 0.00 1000.00 0.00 r_1683 s_0513[e] -> 0.00 1000.00 0.00 -r_1684 s_0511[ce] <=> s_0512[c] -1000.00 1000.00 0.00 +r_1684 s_0511[ce] <=> s_0512[c] ( YGL077C or YOR161C ) -1000.00 1000.00 0.00 r_1685 s_0515[c] -> s_0286[c] + s_1399[c] 0.00 1000.00 0.00 r_1686 s_0523[e] <=> s_0522[c] -1000.00 1000.00 0.00 r_1687 s_0523[e] -> 0.00 1000.00 0.00 @@ -2579,7 +2579,7 @@ r_1703 s_0434[c] + s_0526[c] -> s_0394[c] + s_0467[c] 0.00 1000.00 0.00 r_1704 s_0434[c] + s_0589[c] <=> s_0394[c] + s_0587[c] -1000.00 1000.00 0.00 r_1705 s_0546[e] -> 0.00 1000.00 0.00 r_1706 s_0549[e] -> 0.00 1000.00 0.00 -r_1707 s_0549[e] <=> s_0548[c] -1000.00 1000.00 0.00 +r_1707 s_0549[e] <=> s_0548[c] ( YDR342C or YHR092C ) -1000.00 1000.00 0.00 r_1708 s_0551[c] <=> s_0552[m] -1000.00 1000.00 0.00 r_1709 s_0554[e] -> 0.00 1000.00 0.00 r_1710 s_0559[e] -> 0.00 1000.00 0.00 @@ -2589,9 +2589,9 @@ r_1713 s_0413[e] <=> s_0412[c] -1000.00 1000.00 0.00 r_1714 s_0565[e] <=> -1.00 1000.00 0.00 r_1715 s_0572[e] -> 0.00 1000.00 0.00 r_1716 s_0576[e] -> 0.00 1000.00 0.00 -r_1717 s_0562[e] <=> s_0561[c] -1000.00 1000.00 0.00 +r_1717 s_0562[e] <=> s_0561[c] ( YDL245C or YEL069C or YJR158W or YNR072W ) -1000.00 1000.00 0.00 r_1718 s_0579[e] -> 0.00 1000.00 0.00 -r_1719 s_0579[e] <=> s_0578[c] -1000.00 1000.00 0.00 +r_1719 s_0579[e] <=> s_0578[c] YHR092C -1000.00 1000.00 0.00 r_1720 s_0582[c] <=> s_0583[n] -1000.00 1000.00 0.00 r_1721 s_0587[c] <=> s_0588[n] -1000.00 1000.00 0.00 r_1722 s_0434[c] + s_0794[c] + s_0803[c] -> s_0419[c] + s_0950[c] 0.00 1000.00 0.00 @@ -2607,7 +2607,7 @@ r_1731 s_0611[e] -> s_0610[c] 0.00 1000.00 0.00 r_1732 s_0135[e] -> s_0134[c] 0.00 1000.00 0.00 r_1733 s_0137[e] -> s_0136[c] 0.00 1000.00 0.00 r_1734 s_0138[c] + s_0434[c] -> s_0394[c] + s_0654[c] + s_0794[c] 0.00 1000.00 0.00 -r_1735 s_0139[e] -> s_0138[c] 0.00 1000.00 0.00 +r_1735 s_0139[e] -> s_0138[c] YBL042C 0.00 1000.00 0.00 r_1736 s_0197[c] + s_0434[c] -> s_0394[c] + s_0529[c] + s_0794[c] 0.00 1000.00 0.00 r_1737 s_0613[c] <=> s_0614[n] -1000.00 1000.00 0.00 r_1738 s_0343[c] <=> s_0344[m] -1000.00 1000.00 0.00 @@ -2627,7 +2627,7 @@ r_1754 s_0662[c] <=> s_0663[er] -1000.00 1000.00 0.00 r_1757 s_0668[e] -> 0.00 1000.00 0.00 r_1758 s_0667[er] <=> s_0666[c] -1000.00 1000.00 0.00 r_1759 s_0666[c] <=> s_0669[lp] -1000.00 1000.00 0.00 -r_1760 s_0666[c] <=> s_0665[ce] -1000.00 1000.00 0.00 +r_1760 s_0666[c] <=> s_0665[ce] ( YIL013C or YOR011W ) -1000.00 1000.00 0.00 r_1761 s_0681[e] -> 0.00 1000.00 0.00 r_1762 s_0680[c] <=> s_0681[e] -1000.00 1000.00 0.00 r_1763 s_0680[c] <=> s_0682[m] -1000.00 1000.00 0.00 @@ -2635,9 +2635,9 @@ r_1764 s_0684[e] -> 0.00 1000.00 0.00 r_1765 s_0686[e] -> 0.00 1000.00 0.00 r_1766 s_0190[c] <=> s_0191[m] -1000.00 1000.00 0.00 r_1770 s_0595[c] <=> s_0600[p] -1000.00 1000.00 0.00 -r_1771 s_1065[c] <=> s_1070[p] -1000.00 1000.00 0.00 -r_1772 s_1161[c] <=> s_1166[p] -1000.00 1000.00 0.00 -r_1774 s_1286[c] <=> s_1291[p] -1000.00 1000.00 0.00 +r_1771 s_1065[c] <=> s_1070[p] ( YKL188C and YPL147W ) -1000.00 1000.00 0.00 +r_1772 s_1161[c] <=> s_1166[p] ( YKL188C and YPL147W ) -1000.00 1000.00 0.00 +r_1774 s_1286[c] <=> s_1291[p] ( YKL188C and YPL147W ) -1000.00 1000.00 0.00 r_1775 s_1293[c] <=> s_1298[p] -1000.00 1000.00 0.00 r_1776 s_1248[c] <=> s_1253[p] -1000.00 1000.00 0.00 r_1777 s_1163[e] <=> s_1161[c] -1000.00 1000.00 0.00 @@ -2647,26 +2647,26 @@ r_1791 s_0715[e] -> 0.00 1000.00 0.00 r_1792 s_0720[e] -> 0.00 1000.00 0.00 r_1793 s_0723[e] -> 0.00 1000.00 0.00 r_1794 s_0724[m] -> s_0722[c] 0.00 1000.00 0.00 -r_1795 s_0723[e] <=> s_0722[c] -1000.00 1000.00 0.00 +r_1795 s_0723[e] <=> s_0722[c] YNL065W -1000.00 1000.00 0.00 r_1796 s_0726[e] <=> s_0725[c] -1000.00 1000.00 0.00 r_1797 s_0434[c] + s_0556[c] -> s_0394[c] + s_0555[c] + s_0794[c] 0.00 1000.00 0.00 r_1798 s_0726[e] -> 0.00 1000.00 0.00 r_1800 s_0736[e] -> 0.00 1000.00 0.00 r_1801 s_0740[g] <=> s_0739[c] -1000.00 1000.00 0.00 r_1802 s_0739[c] <=> s_0742[n] -1000.00 1000.00 0.00 -r_1803 s_0743[c] <=> s_0744[g] -1000.00 1000.00 0.00 +r_1803 s_0743[c] <=> s_0744[g] YGL225W -1000.00 1000.00 0.00 r_1805 s_0563[c] <=> s_0566[v] ( YBR241C or YGL104C ) -1000.00 1000.00 0.00 r_1806 s_0755[e] -> 0.00 1000.00 0.00 r_1807 s_0751[e] -> 0.00 1000.00 0.00 r_1808 s_0766[e] -> 0.00 1000.00 0.00 r_1809 s_0767[c] <=> s_0770[m] -1000.00 1000.00 0.00 r_1810 s_1004[e] -> 0.00 1000.00 0.00 -r_1811 s_1003[c] <=> s_1005[m] -1000.00 1000.00 0.00 +r_1811 s_1003[c] <=> s_1005[m] YPR058W -1000.00 1000.00 0.00 r_1812 s_0775[c] <=> s_0777[m] -1000.00 1000.00 0.00 r_1813 s_0776[e] <=> s_0775[c] -1000.00 1000.00 0.00 r_1814 s_0776[e] -> 0.00 1000.00 0.00 r_1815 s_0780[e] -> 0.00 1000.00 0.00 -r_1816 s_0779[c] <=> s_0780[e] -1000.00 1000.00 0.00 +r_1816 s_0779[c] <=> s_0780[e] YNL065W -1000.00 1000.00 0.00 r_1817 s_0779[c] <=> s_0781[p] -1000.00 1000.00 0.00 r_1818 s_0788[e] -> 0.00 1000.00 0.00 r_1819 s_0787[c] <=> s_0789[m] -1000.00 1000.00 0.00 @@ -2686,7 +2686,7 @@ r_1833 s_0816[c] <=> s_0817[er] -1000.00 1000.00 0.00 r_1834 s_0826[e] -> 0.00 1000.00 0.00 r_1835 s_1288[e] <=> s_1286[c] -1000.00 1000.00 0.00 r_1836 s_1295[e] <=> s_1293[c] -1000.00 1000.00 0.00 -r_1837 s_1006[c] -> s_1008[m] 0.00 1000.00 0.00 +r_1837 s_1006[c] -> s_1008[m] YBR147W 0.00 1000.00 0.00 r_1839 s_0837[c] <=> s_0839[n] -1000.00 1000.00 0.00 r_1840 s_0218[c] <=> s_0221[m] -1000.00 1000.00 0.00 r_1841 s_0844[e] -> 0.00 1000.00 0.00 @@ -2725,12 +2725,12 @@ r_1873 s_0956[e] -> 0.00 1000.00 0.00 r_1874 s_0957[m] -> s_0955[c] 0.00 1000.00 0.00 r_1875 s_0962[e] -> 0.00 1000.00 0.00 r_1876 s_0962[e] <=> s_0961[c] -1000.00 1000.00 0.00 -r_1877 s_0964[e] <=> s_0963[c] -1000.00 1000.00 0.00 +r_1877 s_0964[e] <=> s_0963[c] ( YDR342C or YHR092C ) -1000.00 1000.00 0.00 r_1878 s_0964[e] -> 0.00 1000.00 0.00 r_1879 s_0966[e] -> 0.00 1000.00 0.00 r_1880 s_0970[e] -> 0.00 1000.00 0.00 r_1881 s_0974[e] -> 0.00 1000.00 0.00 -r_1882 s_0023[m] -> s_0021[c] 0.00 1000.00 0.00 +r_1882 s_0023[m] -> s_0021[c] YOR100C 0.00 1000.00 0.00 r_1883 s_0982[e] -> 0.00 1000.00 0.00 r_1884 s_0677[c] <=> s_0678[m] -1000.00 1000.00 0.00 r_1885 s_0677[c] <=> s_0679[p] -1000.00 1000.00 0.00 @@ -2753,17 +2753,17 @@ r_1903 s_1033[e] -> 0.00 1000.00 0.00 r_1904 s_1036[e] -> 0.00 1000.00 0.00 r_1905 s_1035[c] <=> s_1037[m] -1000.00 1000.00 0.00 r_1906 s_1041[e] -> 0.00 1000.00 0.00 -r_1907 s_1039[c] <=> s_1040[er] -1000.00 1000.00 0.00 -r_1908 s_0990[e] <=> s_0989[c] -1000.00 1000.00 0.00 +r_1907 s_1039[c] <=> s_1040[er] YKR039W -1000.00 1000.00 0.00 +r_1908 s_0990[e] <=> s_0989[c] ( YDL245C or YEL069C or YJR158W or YNR072W ) -1000.00 1000.00 0.00 r_1909 s_1044[e] -> 0.00 1000.00 0.00 -r_1910 s_1044[e] <=> s_1043[c] -1000.00 1000.00 0.00 +r_1910 s_1044[e] <=> s_1043[c] ( YDL245C or YDR342C or YDR343C or YDR345C or YEL069C or YFL011W or YHR092C or YHR094C or YHR096C or YJL214W or YJL219W or YJR158W or YMR011W or YNR072W or YOL156W ) -1000.00 1000.00 0.00 r_1911 s_1046[e] -> 0.00 1000.00 0.00 r_1912 s_1049[e] -> 0.00 1000.00 0.00 r_1913 s_1052[e] -> 0.00 1000.00 0.00 r_1914 s_1057[e] -> 0.00 1000.00 0.00 r_1915 s_1061[e] -> 0.00 1000.00 0.00 r_1916 s_1067[e] -> 0.00 1000.00 0.00 -r_1919 s_1025[c] -> s_1027[m] 0.00 1000.00 0.00 +r_1919 s_1025[c] -> s_1027[m] YBR147W 0.00 1000.00 0.00 r_1920 s_0862[g] <=> s_0861[er] -1000.00 1000.00 0.00 r_1921 s_0868[g] <=> s_0867[er] -1000.00 1000.00 0.00 r_1922 s_0874[g] <=> s_0873[er] -1000.00 1000.00 0.00 @@ -2777,7 +2777,7 @@ r_1929 s_0889[g] <=> s_0888[er] -1000.00 1000.00 0.00 r_1930 s_0069[p] + s_1271[c] <=> s_0066[c] + s_1274[p] -1000.00 1000.00 0.00 r_1931 s_1106[e] -> 0.00 1000.00 0.00 r_1932 s_1107[c] <=> s_1108[er] -1000.00 1000.00 0.00 -r_1935 s_1031[m] -> s_1029[c] 0.00 1000.00 0.00 +r_1935 s_1031[m] -> s_1029[c] YDR508C 0.00 1000.00 0.00 r_1936 s_0629[c] -> s_1151[c] + s_1322[c] 0.00 1000.00 0.00 r_1937 s_1117[g] <=> s_1116[er] -1000.00 1000.00 0.00 r_1938 s_1123[g] <=> s_1122[er] -1000.00 1000.00 0.00 @@ -2802,7 +2802,7 @@ r_1971 s_1224[c] <=> s_1228[p] -1000.00 1000.00 0.00 r_1972 s_1225[e] -> s_1224[c] 0.00 1000.00 0.00 r_1974 s_0613[c] + s_0803[c] -> s_0615[c] + s_0794[c] + s_1322[c] 0.00 1000.00 0.00 r_1975 s_0617[c] + s_0803[c] -> s_0613[c] + s_0794[c] + s_1322[c] 0.00 1000.00 0.00 -r_1976 s_1235[c] -> s_1236[m] 0.00 1000.00 0.00 +r_1976 s_1235[c] -> s_1236[m] YOR100C 0.00 1000.00 0.00 r_1977 s_1275[c] <=> s_1276[er] -1000.00 1000.00 0.00 r_1978 s_1275[c] <=> s_1278[m] -1000.00 1000.00 0.00 r_1979 s_1277[e] <=> s_1275[c] -1000.00 1000.00 0.00 @@ -2812,7 +2812,7 @@ r_1984 s_1250[e] -> 0.00 1000.00 0.00 r_1987 s_1267[e] -> 0.00 1000.00 0.00 r_1988 s_1271[c] <=> s_1272[e] -1000.00 1000.00 0.00 r_1989 s_1272[e] -> 0.00 1000.00 0.00 -r_1990 s_0755[e] -> s_0754[c] 0.00 1000.00 0.00 +r_1990 s_0755[e] -> s_0754[c] YJL212C 0.00 1000.00 0.00 r_1991 s_1620[c] <=> s_1623[p] -1000.00 1000.00 0.00 r_1992 s_1277[e] <=> -1000.00 1000.00 0.00 r_1993 s_1288[e] -> 0.00 1000.00 0.00 @@ -2828,7 +2828,7 @@ r_2002 s_1318[c] <=> s_1319[e] -1000.00 1000.00 0.00 r_2003 s_1318[c] <=> s_1320[m] -1000.00 1000.00 0.00 r_2004 s_1032[c] -> s_1034[m] 0.00 1000.00 0.00 r_2005 s_1324[e] <=> -1000.00 1000.00 0.00 -r_2008 s_1322[c] <=> s_1329[v] -1000.00 1000.00 0.00 +r_2008 s_1322[c] <=> s_1329[v] YNR013C -1000.00 1000.00 0.00 r_2020 s_1374[e] <=> -1000.00 1000.00 0.00 r_2022 s_1384[c] <=> s_1385[m] -1000.00 1000.00 0.00 r_2023 s_1386[c] <=> s_1387[m] -1000.00 1000.00 0.00 @@ -2845,12 +2845,12 @@ r_2036 s_1403[c] <=> s_1404[m] -1000.00 1000.00 0.00 r_2037 s_1616[c] <=> s_1619[p] -1000.00 1000.00 0.00 r_2038 s_1406[e] -> 0.00 1000.00 0.00 r_2039 s_1405[c] -> s_1407[m] 0.00 1000.00 0.00 -r_2040 s_1406[e] -> s_1405[c] 0.00 1000.00 0.00 -r_2041 s_0576[e] -> s_0575[c] 0.00 1000.00 0.00 +r_2040 s_1406[e] -> s_1405[c] YOR306C 0.00 1000.00 0.00 +r_2041 s_0576[e] -> s_0575[c] ( YDR342C or YHR092C ) 0.00 1000.00 0.00 r_2042 s_1413[c] <=> s_1415[m] -1000.00 1000.00 0.00 r_2043 s_1418[e] -> 0.00 1000.00 0.00 r_2044 s_1425[e] -> 0.00 1000.00 0.00 -r_2045 s_1039[c] <=> s_1042[m] -1000.00 1000.00 0.00 +r_2045 s_1039[c] <=> s_1042[m] YDR508C -1000.00 1000.00 0.00 r_2046 s_1435[e] -> 0.00 1000.00 0.00 r_2049 s_1438[e] <=> -1000.00 1000.00 0.00 r_2050 s_0373[c] + s_1439[c] -> s_0529[c] + s_0794[c] + s_1180[c] 0.00 1000.00 0.00 @@ -2874,7 +2874,7 @@ r_2068 s_1498[e] -> 0.00 1000.00 0.00 r_2069 s_0434[c] + s_1497[c] -> s_0394[c] + s_1475[c] 0.00 1000.00 0.00 r_2070 s_0794[c] + s_0981[c] + s_1003[c] + s_1233[c] + s_1408[c] -> s_0293[c] + s_0362[c] + s_0419[c] + s_0456[c] + s_0734[c] + 3 s_0803[c] + s_1399[c] 0.00 1000.00 0.00 r_2071 s_0581[c] + s_0794[c] + s_0981[c] + s_1003[c] + s_1233[c] -> s_0293[c] + s_0362[c] + s_0419[c] + s_0456[c] + s_0734[c] + 3 s_0803[c] + s_1399[c] 0.00 1000.00 0.00 -r_2072 s_1045[c] -> s_1047[m] 0.00 1000.00 0.00 +r_2072 s_1045[c] -> s_1047[m] YDR508C 0.00 1000.00 0.00 r_2073 s_1494[e] -> 0.00 1000.00 0.00 r_2074 s_0434[c] + s_1493[c] -> s_0394[c] + s_0649[c] + s_0794[c] 0.00 1000.00 0.00 r_2075 s_1494[e] <=> s_1493[c] -1000.00 1000.00 0.00 @@ -2890,7 +2890,7 @@ r_2090 s_1551[e] -> 0.00 1000.00 0.00 r_2091 s_1553[e] -> 0.00 1000.00 0.00 r_2092 s_1557[e] -> 0.00 1000.00 0.00 r_2093 s_1056[c] <=> s_1058[m] -1000.00 1000.00 0.00 -r_2094 s_0803[c] <=> s_0804[er] -1000.00 1000.00 0.00 +r_2094 s_0803[c] <=> s_0804[er] ( YLL052C or YPR192W ) -1000.00 1000.00 0.00 r_2095 s_0803[c] <=> s_0806[g] -1000.00 1000.00 0.00 r_2096 s_0803[c] <=> s_0807[m] -1000.00 1000.00 0.00 r_2097 s_0803[c] <=> s_0808[n] -1000.00 1000.00 0.00 @@ -2901,9 +2901,9 @@ r_2101 s_0358[e] <=> s_0357[c] -1000.00 1000.00 0.00 r_2102 s_1564[e] -> 0.00 1000.00 0.00 r_2103 s_1564[e] -> s_1563[c] 0.00 1000.00 0.00 r_2104 s_1567[e] -> 0.00 1000.00 0.00 -r_2105 s_1567[e] <=> s_1566[c] -1000.00 1000.00 0.00 +r_2105 s_1567[e] <=> s_1566[c] ( YDL245C or YLL043W ) -1000.00 1000.00 0.00 r_2106 s_1571[e] -> 0.00 1000.00 0.00 -r_2107 s_1568[ce] <=> s_1569[c] -1000.00 1000.00 0.00 +r_2107 s_1568[ce] <=> s_1569[c] ( YIL013C or YOR011W ) -1000.00 1000.00 0.00 r_2108 s_3746[c] + s_3747[c] -> s_1096[c] 0.00 1000.00 0.00 r_2111 s_0450[c] -> 0.00 1000.00 1.00 r_2125 s_0529[c] <=> s_0531[lp] -1000.00 1000.00 0.00 @@ -2918,13 +2918,13 @@ r_2186 s_1067[e] <=> s_1065[c] -1000.00 1000.00 0.00 r_2187 s_2822[e] -> 0.00 1000.00 0.00 r_2188 s_2824[e] -> 0.00 1000.00 0.00 r_2189 s_2826[e] -> 0.00 1000.00 0.00 -r_2190 s_2822[e] <=> s_2828[c] -1000.00 1000.00 0.00 -r_2191 s_2824[e] <=> s_2829[c] -1000.00 1000.00 0.00 +r_2190 s_2822[e] <=> s_2828[c] YNL065W -1000.00 1000.00 0.00 +r_2191 s_2824[e] <=> s_2829[c] YNL065W -1000.00 1000.00 0.00 r_2192 s_2826[e] <=> s_1260[c] -1000.00 1000.00 0.00 r_2193 s_1163[e] -> 0.00 1000.00 0.00 r_2229 s_2828[c] <=> s_2882[p] -1000.00 1000.00 0.00 r_2230 s_2829[c] <=> s_2883[p] -1000.00 1000.00 0.00 -r_2231 s_1260[c] <=> s_2855[p] -1000.00 1000.00 0.00 +r_2231 s_1260[c] <=> s_2855[p] ( YKL188C and YPL147W ) -1000.00 1000.00 0.00 r_2812 s_3297[mm] + s_3320[mm] -> s_3296[mm] + s_3321[mm] 0.00 1000.00 0.00 r_2813 s_3297[mm] + s_3322[mm] -> s_3304[mm] + s_3321[mm] 0.00 1000.00 0.00 r_2814 s_3299[mm] + s_3320[mm] -> s_3298[mm] + s_3321[mm] 0.00 1000.00 0.00 @@ -2967,7 +2967,7 @@ r_3522 s_2880[c] <=> s_2795[erm] -1000.00 1000.00 0.00 r_3523 s_1479[c] <=> s_2797[erm] -1000.00 1000.00 0.00 r_3524 s_0816[c] <=> s_2816[erm] -1000.00 1000.00 0.00 r_3525 s_0794[c] <=> s_2783[erm] -1000.00 1000.00 0.00 -r_3526 s_0803[c] <=> s_2808[erm] -1000.00 1000.00 0.00 +r_3526 s_0803[c] <=> s_2808[erm] ( YLL052C or YPR192W ) -1000.00 1000.00 0.00 r_3527 s_0456[c] <=> s_2784[erm] -1000.00 1000.00 0.00 r_3528 s_0529[c] <=> s_2785[erm] -1000.00 1000.00 0.00 r_3529 s_1212[c] <=> s_2799[erm] -1000.00 1000.00 0.00 @@ -2986,7 +2986,7 @@ r_3541 s_0474[c] <=> s_3216[erm] -1000.00 1000.00 0.00 r_3542 s_0469[c] <=> s_3217[erm] -1000.00 1000.00 0.00 r_3543 s_0434[c] <=> s_2831[erm] -1000.00 1000.00 0.00 r_3544 s_0423[c] <=> s_2833[erm] -1000.00 1000.00 0.00 -r_3545 s_1039[c] <=> s_3107[erm] -1000.00 1000.00 0.00 +r_3545 s_1039[c] <=> s_3107[erm] YKR039W -1000.00 1000.00 0.00 r_3546 s_1153[c] <=> s_3117[erm] -1000.00 1000.00 0.00 r_3547 s_1416[c] <=> s_3182[erm] -1000.00 1000.00 0.00 r_3548 s_1413[c] <=> s_3183[erm] -1000.00 1000.00 0.00 @@ -3045,10 +3045,10 @@ r_3600 s_2876[lp] <=> s_0816[c] -1000.00 1000.00 0.00 r_3601 s_0434[c] <=> s_2856[ce] -1000.00 1000.00 0.00 r_3602 s_0394[c] <=> s_3324[ce] -1000.00 1000.00 0.00 r_3603 s_0794[c] <=> s_0793[ce] -1000.00 1000.00 0.00 -r_3604 s_0803[c] <=> s_3449[ce] -1000.00 1000.00 0.00 -r_3605 s_1322[c] <=> s_3536[ce] -1000.00 1000.00 0.00 -r_3606 s_1432[ce] <=> s_1433[c] -1000.00 1000.00 0.00 -r_3607 s_3495[ce] <=> s_0079[c] -1000.00 1000.00 0.00 +r_3604 s_0803[c] <=> s_3449[ce] ( YLL052C or YLL053C or YPR192W ) -1000.00 1000.00 0.00 +r_3605 s_1322[c] <=> s_3536[ce] ( YCR037C or YJL198W or YML123C ) -1000.00 1000.00 0.00 +r_3606 s_1432[ce] <=> s_1433[c] YCR098C -1000.00 1000.00 0.00 +r_3607 s_3495[ce] <=> s_0079[c] YCR098C -1000.00 1000.00 0.00 r_3608 s_3463[ce] <=> s_1286[c] -1000.00 1000.00 0.00 r_3609 s_3451[ce] <=> s_1293[c] -1000.00 1000.00 0.00 r_3610 s_3464[ce] <=> s_1449[c] -1000.00 1000.00 0.00 @@ -3090,7 +3090,7 @@ r_3645 s_3518[n] <=> s_3508[c] -1000.00 1000.00 0.00 r_3646 s_3519[n] <=> s_3510[c] -1000.00 1000.00 0.00 r_3647 s_3520[n] <=> s_3512[c] -1000.00 1000.00 0.00 r_3648 s_0803[c] <=> s_2976[vm] -1000.00 1000.00 0.00 -r_3649 s_1322[c] <=> s_2977[vm] -1000.00 1000.00 0.00 +r_3649 s_1322[c] <=> s_2977[vm] YNR013C -1000.00 1000.00 0.00 r_3650 s_0794[c] <=> s_3164[vm] -1000.00 1000.00 0.00 r_3651 s_0434[c] <=> s_3341[vm] -1000.00 1000.00 0.00 r_3652 s_0394[c] <=> s_3342[vm] -1000.00 1000.00 0.00 @@ -3121,7 +3121,7 @@ r_3676 s_3525[mm] <=> s_3506[c] -1000.00 1000.00 0.00 r_3677 s_3526[mm] <=> s_3508[c] -1000.00 1000.00 0.00 r_3678 s_3271[mm] <=> s_1286[c] -1000.00 1000.00 0.00 r_3679 s_3277[mm] <=> s_1449[c] -1000.00 1000.00 0.00 -r_3680 s_3321[mm] <=> s_0529[c] -1000.00 1000.00 0.00 +r_3680 s_3321[mm] <=> s_0529[c] YHR002W -1000.00 1000.00 0.00 r_3681 s_2832[erm] <=> s_2841[lp] -1000.00 1000.00 0.00 r_3682 s_2835[erm] <=> s_2844[lp] -1000.00 1000.00 0.00 r_3683 s_2869[erm] <=> s_2873[lp] -1000.00 1000.00 0.00 @@ -3254,22 +3254,22 @@ r_3809 s_3122[erm] <=> s_3368[gm] -1000.00 1000.00 0.00 r_3810 s_3123[erm] <=> s_3370[gm] -1000.00 1000.00 0.00 r_3811 s_3124[erm] <=> s_3372[gm] -1000.00 1000.00 0.00 r_3812 s_3125[erm] <=> s_3374[gm] -1000.00 1000.00 0.00 -r_3813 s_3109[erm] <=> s_3145[gm] -1000.00 1000.00 0.00 -r_3814 s_3110[erm] <=> s_3149[gm] -1000.00 1000.00 0.00 -r_3815 s_3111[erm] <=> s_3151[gm] -1000.00 1000.00 0.00 -r_3816 s_3112[erm] <=> s_3153[gm] -1000.00 1000.00 0.00 -r_3817 s_3113[erm] <=> s_3155[gm] -1000.00 1000.00 0.00 -r_3818 s_3114[erm] <=> s_3157[gm] -1000.00 1000.00 0.00 -r_3819 s_3115[erm] <=> s_3159[gm] -1000.00 1000.00 0.00 -r_3820 s_3116[erm] <=> s_3161[gm] -1000.00 1000.00 0.00 -r_3821 s_3148[gm] <=> s_3181[erm] -1000.00 1000.00 0.00 -r_3822 s_3150[gm] <=> s_3185[erm] -1000.00 1000.00 0.00 -r_3823 s_3152[gm] <=> s_3187[erm] -1000.00 1000.00 0.00 -r_3824 s_3154[gm] <=> s_3189[erm] -1000.00 1000.00 0.00 -r_3825 s_3156[gm] <=> s_3191[erm] -1000.00 1000.00 0.00 -r_3826 s_3158[gm] <=> s_3193[erm] -1000.00 1000.00 0.00 -r_3827 s_3160[gm] <=> s_3195[erm] -1000.00 1000.00 0.00 -r_3828 s_3162[gm] <=> s_3197[erm] -1000.00 1000.00 0.00 +r_3813 s_3109[erm] <=> s_3145[gm] ( YIL048W or YMR162C ) -1000.00 1000.00 0.00 +r_3814 s_3110[erm] <=> s_3149[gm] ( YIL048W or YMR162C ) -1000.00 1000.00 0.00 +r_3815 s_3111[erm] <=> s_3151[gm] ( YIL048W or YMR162C ) -1000.00 1000.00 0.00 +r_3816 s_3112[erm] <=> s_3153[gm] ( YIL048W or YMR162C ) -1000.00 1000.00 0.00 +r_3817 s_3113[erm] <=> s_3155[gm] ( YIL048W or YMR162C ) -1000.00 1000.00 0.00 +r_3818 s_3114[erm] <=> s_3157[gm] ( YIL048W or YMR162C ) -1000.00 1000.00 0.00 +r_3819 s_3115[erm] <=> s_3159[gm] ( YIL048W or YMR162C ) -1000.00 1000.00 0.00 +r_3820 s_3116[erm] <=> s_3161[gm] ( YIL048W or YMR162C ) -1000.00 1000.00 0.00 +r_3821 s_3148[gm] <=> s_3181[erm] YAL026C -1000.00 1000.00 0.00 +r_3822 s_3150[gm] <=> s_3185[erm] YAL026C -1000.00 1000.00 0.00 +r_3823 s_3152[gm] <=> s_3187[erm] YAL026C -1000.00 1000.00 0.00 +r_3824 s_3154[gm] <=> s_3189[erm] YAL026C -1000.00 1000.00 0.00 +r_3825 s_3156[gm] <=> s_3191[erm] YAL026C -1000.00 1000.00 0.00 +r_3826 s_3158[gm] <=> s_3193[erm] YAL026C -1000.00 1000.00 0.00 +r_3827 s_3160[gm] <=> s_3195[erm] YAL026C -1000.00 1000.00 0.00 +r_3828 s_3162[gm] <=> s_3197[erm] YAL026C -1000.00 1000.00 0.00 r_3829 s_2954[erm] <=> s_2975[vm] -1000.00 1000.00 0.00 r_3830 s_2956[erm] <=> s_2981[vm] -1000.00 1000.00 0.00 r_3831 s_2958[erm] <=> s_2985[vm] -1000.00 1000.00 0.00 @@ -3326,22 +3326,22 @@ r_3881 s_3211[erm] <=> s_3458[ce] -1000.00 1000.00 0.00 r_3882 s_3212[erm] <=> s_3460[ce] -1000.00 1000.00 0.00 r_3883 s_3213[erm] <=> s_3461[ce] -1000.00 1000.00 0.00 r_3884 s_3214[erm] <=> s_3462[ce] -1000.00 1000.00 0.00 -r_3885 s_3181[erm] <=> s_3465[ce] -1000.00 1000.00 0.00 -r_3886 s_3185[erm] <=> s_3467[ce] -1000.00 1000.00 0.00 -r_3887 s_3187[erm] <=> s_3469[ce] -1000.00 1000.00 0.00 -r_3888 s_3189[erm] <=> s_3471[ce] -1000.00 1000.00 0.00 -r_3889 s_3191[erm] <=> s_3473[ce] -1000.00 1000.00 0.00 -r_3890 s_3193[erm] <=> s_3474[ce] -1000.00 1000.00 0.00 -r_3891 s_3195[erm] <=> s_3475[ce] -1000.00 1000.00 0.00 -r_3892 s_3197[erm] <=> s_3476[ce] -1000.00 1000.00 0.00 -r_3893 s_3109[erm] <=> s_3478[ce] -1000.00 1000.00 0.00 -r_3894 s_3110[erm] <=> s_3480[ce] -1000.00 1000.00 0.00 -r_3895 s_3111[erm] <=> s_3482[ce] -1000.00 1000.00 0.00 -r_3896 s_3112[erm] <=> s_3484[ce] -1000.00 1000.00 0.00 -r_3897 s_3113[erm] <=> s_3486[ce] -1000.00 1000.00 0.00 -r_3898 s_3114[erm] <=> s_3487[ce] -1000.00 1000.00 0.00 -r_3899 s_3115[erm] <=> s_3488[ce] -1000.00 1000.00 0.00 -r_3900 s_3116[erm] <=> s_3489[ce] -1000.00 1000.00 0.00 +r_3885 s_3181[erm] <=> s_3465[ce] YAL026C -1000.00 1000.00 0.00 +r_3886 s_3185[erm] <=> s_3467[ce] YAL026C -1000.00 1000.00 0.00 +r_3887 s_3187[erm] <=> s_3469[ce] YAL026C -1000.00 1000.00 0.00 +r_3888 s_3189[erm] <=> s_3471[ce] YAL026C -1000.00 1000.00 0.00 +r_3889 s_3191[erm] <=> s_3473[ce] YAL026C -1000.00 1000.00 0.00 +r_3890 s_3193[erm] <=> s_3474[ce] YAL026C -1000.00 1000.00 0.00 +r_3891 s_3195[erm] <=> s_3475[ce] YAL026C -1000.00 1000.00 0.00 +r_3892 s_3197[erm] <=> s_3476[ce] YAL026C -1000.00 1000.00 0.00 +r_3893 s_3109[erm] <=> s_3478[ce] YIL048W -1000.00 1000.00 0.00 +r_3894 s_3110[erm] <=> s_3480[ce] YIL048W -1000.00 1000.00 0.00 +r_3895 s_3111[erm] <=> s_3482[ce] YIL048W -1000.00 1000.00 0.00 +r_3896 s_3112[erm] <=> s_3484[ce] YIL048W -1000.00 1000.00 0.00 +r_3897 s_3113[erm] <=> s_3486[ce] YIL048W -1000.00 1000.00 0.00 +r_3898 s_3114[erm] <=> s_3487[ce] YIL048W -1000.00 1000.00 0.00 +r_3899 s_3115[erm] <=> s_3488[ce] YIL048W -1000.00 1000.00 0.00 +r_3900 s_3116[erm] <=> s_3489[ce] YIL048W -1000.00 1000.00 0.00 r_3901 s_2864[ce] <=> s_2869[erm] -1000.00 1000.00 0.00 r_3902 s_2866[ce] <=> s_2870[erm] -1000.00 1000.00 0.00 r_3903 s_3527[ce] <=> s_2954[erm] -1000.00 1000.00 0.00 @@ -3400,9 +3400,9 @@ r_3955 s_3422[vm] <=> s_3598[ce] -1000.00 1000.00 0.00 r_3956 s_3423[vm] <=> s_3599[ce] -1000.00 1000.00 0.00 r_3957 s_0799[m] <=> s_3094[mm] -1000.00 1000.00 0.00 r_3958 s_0770[m] <=> s_3218[mm] -1000.00 1000.00 0.00 -r_3959 s_0528[m] <=> s_3219[mm] -1000.00 1000.00 0.00 -r_3960 s_0541[m] <=> s_3093[mm] -1000.00 1000.00 0.00 -r_3961 s_1326[m] <=> s_3228[mm] -1000.00 1000.00 0.00 +r_3959 s_0528[m] <=> s_3219[mm] YBR192W -1000.00 1000.00 0.00 +r_3960 s_0541[m] <=> s_3093[mm] YBR192W -1000.00 1000.00 0.00 +r_3961 s_1326[m] <=> s_3228[mm] ( YER053C or YJR077C or YLR348C ) -1000.00 1000.00 0.00 r_3962 s_0636[m] <=> s_3095[mm] -1000.00 1000.00 0.00 r_3973 s_3709[erm] <=> s_0672[c] -1000.00 1000.00 0.00 r_3987 s_3710[erm] <=> s_1337[c] -1000.00 1000.00 0.00 @@ -3722,7 +3722,7 @@ r_4357 s_0803[c] + s_4081[c] -> s_1322[c] + s_1556[c] 0.00 1000.00 0.00 r_4358 s_0796[e] + s_4082[e] <=> s_0794[c] + s_4081[c] -1000.00 1000.00 0.00 r_4359 s_0803[c] + s_4083[c] -> s_1322[c] + s_1556[c] 0.00 1000.00 0.00 r_4360 s_0796[e] + s_4084[e] <=> s_0794[c] + s_4083[c] -1000.00 1000.00 0.00 -r_4361 s_0796[e] + s_4085[e] <=> s_0794[c] + s_4086[c] -1000.00 1000.00 0.00 +r_4361 s_0796[e] + s_4085[e] <=> s_0794[c] + s_4086[c] ( YJR152W or YKR093W ) -1000.00 1000.00 0.00 r_4362 s_0810[v] + s_4087[v] -> s_3758[v] + s_3839[v] 0.00 1000.00 0.00 r_4363 s_4088[c] -> s_1322[c] + s_4089[c] 0.00 1000.00 0.00 r_4364 s_0796[e] + s_4090[e] <=> s_0794[c] + s_4088[c] -1000.00 1000.00 0.00 @@ -3748,7 +3748,7 @@ r_4383 s_4114[e] <=> s_4112[c] -1000.00 1000.00 0.00 r_4384 s_0794[c] + s_1212[c] + s_4117[c] -> s_1207[c] + s_3875[c] 0.00 1000.00 0.00 r_4385 s_0796[e] + s_4118[e] <=> s_0794[c] + s_4117[c] -1000.00 1000.00 0.00 r_4386 s_0810[v] + s_4121[v] -> s_0977[v] + s_3759[v] 0.00 1000.00 0.00 -r_4387 s_0796[e] + s_4119[e] <=> s_0794[c] + s_4120[c] -1000.00 1000.00 0.00 +r_4387 s_0796[e] + s_4119[e] <=> s_0794[c] + s_4120[c] ( YJR152W or YKR093W ) -1000.00 1000.00 0.00 r_4388 s_0803[c] + s_4126[c] -> s_0794[c] + s_4100[c] 0.00 1000.00 0.00 r_4389 s_0796[e] + s_4127[e] <=> s_0794[c] + s_4126[c] -1000.00 1000.00 0.00 r_4390 s_0803[c] + s_4122[c] <=> s_0563[c] + s_4123[c] -1000.00 1000.00 0.00 @@ -3756,20 +3756,20 @@ r_4391 s_4123[c] -> s_4124[e] 0.00 1000.00 0.00 r_4392 s_0796[e] + s_4125[e] <=> s_0794[c] + s_4122[c] -1000.00 1000.00 0.00 r_4393 s_0434[c] + s_4128[c] -> s_0394[c] + s_0794[c] + s_4129[c] 0.00 1000.00 0.00 r_4394 s_4129[c] <=> s_0557[c] -1000.00 1000.00 0.00 -r_4395 s_4130[e] <=> s_4128[c] -1000.00 1000.00 0.00 +r_4395 s_4130[e] <=> s_4128[c] ( YDL245C or YDR342C or YDR343C or YDR345C or YEL069C or YFL011W or YHR092C or YHR094C or YHR096C or YJL214W or YJL219W or YJR158W or YMR011W or YNR072W or YOL156W ) -1000.00 1000.00 0.00 r_4396 s_0434[c] + s_0529[c] + s_4132[c] -> s_0367[c] + s_0423[c] + s_0633[c] 0.00 1000.00 0.00 r_4397 s_0803[c] + s_4134[c] <=> s_0362[c] + s_1029[c] -1000.00 1000.00 0.00 -r_4398 s_0796[e] + s_4034[e] <=> s_0794[c] + s_4035[c] -1000.00 1000.00 0.00 +r_4398 s_0796[e] + s_4034[e] <=> s_0794[c] + s_4035[c] ( YJR152W or YKR093W ) -1000.00 1000.00 0.00 r_4399 s_0794[c] + s_4038[c] <=> s_0802[v] + s_4039[v] -1000.00 1000.00 0.00 r_4400 s_0805[e] + s_4140[e] -> s_0565[e] + s_1106[e] 0.00 1000.00 0.00 r_4401 s_0794[c] + s_4041[c] <=> s_0802[v] + s_4042[v] -1000.00 1000.00 0.00 -r_4402 s_0796[e] + s_4040[e] <=> s_0794[c] + s_4041[c] -1000.00 1000.00 0.00 +r_4402 s_0796[e] + s_4040[e] <=> s_0794[c] + s_4041[c] ( YJR152W or YKR093W ) -1000.00 1000.00 0.00 r_4403 s_0803[c] + s_4098[c] -> s_0633[c] + s_1322[c] ( YHR201C or YDR452W ) 0.00 1000.00 0.00 -r_4404 s_0796[e] + s_4053[e] <=> s_0794[c] + s_4054[c] -1000.00 1000.00 0.00 +r_4404 s_0796[e] + s_4053[e] <=> s_0794[c] + s_4054[c] ( YJR152W or YKR093W ) -1000.00 1000.00 0.00 r_4405 s_4049[e] <=> s_4048[c] -1000.00 1000.00 0.00 r_4406 s_0796[e] + s_4078[e] <=> s_0794[c] + s_4077[c] -1000.00 1000.00 0.00 r_4407 s_0803[c] + s_4077[c] <=> s_1322[c] + s_3904[c] -1000.00 1000.00 0.00 -r_4408 s_0796[e] + s_4037[e] <=> s_0794[c] + s_4038[c] -1000.00 1000.00 0.00 +r_4408 s_0796[e] + s_4037[e] <=> s_0794[c] + s_4038[c] ( YJR152W or YKR093W ) -1000.00 1000.00 0.00 r_4409 s_0810[v] + s_4039[v] -> s_0996[v] + s_3759[v] 0.00 1000.00 0.00 r_4410 s_4136[c] <=> s_0779[c] + s_1271[c] -1000.00 1000.00 0.00 r_4411 s_0803[c] + s_4138[c] -> s_0419[c] + s_1399[c] + s_1469[c] 0.00 1000.00 0.00 @@ -3785,12 +3785,12 @@ r_4420 s_0805[e] + s_4131[e] <=> s_0554[e] + s_0565[e] -1000.00 1000.00 0.0 r_4421 s_0796[e] + s_4116[e] <=> s_0794[c] + s_4115[c] -1000.00 1000.00 0.00 r_4422 s_0796[e] + s_4137[e] <=> s_0794[c] + s_4136[c] -1000.00 1000.00 0.00 r_4423 s_0794[c] + s_4086[c] <=> s_0802[v] + s_4087[v] -1000.00 1000.00 0.00 -r_4424 s_0796[e] + s_4056[e] <=> s_0794[c] + s_4057[c] -1000.00 1000.00 0.00 +r_4424 s_0796[e] + s_4056[e] <=> s_0794[c] + s_4057[c] ( YJR152W or YKR093W ) -1000.00 1000.00 0.00 r_4425 s_0794[c] + s_4057[c] <=> s_0802[v] + s_4058[v] -1000.00 1000.00 0.00 r_4426 s_0794[c] + s_4035[c] <=> s_0802[v] + s_4036[v] -1000.00 1000.00 0.00 r_4427 s_0796[e] + s_4135[e] <=> s_0794[c] + s_4134[c] -1000.00 1000.00 0.00 r_4428 s_0796[e] + s_4097[e] <=> s_0794[c] + s_4096[c] -1000.00 1000.00 0.00 -r_4429 s_0796[e] + s_4050[e] <=> s_0794[c] + s_4051[c] -1000.00 1000.00 0.00 +r_4429 s_0796[e] + s_4050[e] <=> s_0794[c] + s_4051[c] ( YJR152W or YKR093W ) -1000.00 1000.00 0.00 r_4430 s_0794[c] + s_4051[c] <=> s_0802[v] + s_4052[v] -1000.00 1000.00 0.00 r_4431 s_0794[c] + s_4120[c] <=> s_0802[v] + s_4121[v] -1000.00 1000.00 0.00 r_4432 s_0717[c] + s_1275[c] + s_4115[c] -> s_0714[c] + s_0775[c] + s_0794[c] + s_0803[c] + s_1469[c] 0.00 1000.00 0.00 @@ -3798,7 +3798,7 @@ r_4433 s_4045[e] <=> s_4044[c] -1000.00 1000.00 0.00 r_4434 s_4047[e] <=> s_4046[c] -1000.00 1000.00 0.00 r_4435 s_0803[c] + s_4048[c] -> s_0765[c] + s_1322[c] ( YIL053W or YER062C ) 0.00 1000.00 0.00 r_4436 s_0803[c] + s_4046[c] -> s_1322[c] + s_1493[c] 0.00 1000.00 0.00 -r_4437 s_0796[e] + s_4059[e] <=> s_0794[c] + s_4060[c] -1000.00 1000.00 0.00 +r_4437 s_0796[e] + s_4059[e] <=> s_0794[c] + s_4060[c] ( YJR152W or YKR093W ) -1000.00 1000.00 0.00 r_4438 s_0794[c] + s_4060[c] <=> s_0802[v] + s_4061[v] -1000.00 1000.00 0.00 r_4439 s_0810[v] + s_4061[v] -> s_0996[v] + s_3839[v] 0.00 1000.00 0.00 r_4440 s_1029[c] <=> s_3758[v] -1000.00 1000.00 0.00 @@ -3809,7 +3809,7 @@ r_4444 s_0796[e] + s_4141[e] <=> s_0188[c] + s_0794[c] -1000.00 1000.00 0.0 r_4445 s_0796[e] + s_4142[e] <=> s_0260[c] + s_0794[c] -1000.00 1000.00 0.00 r_4446 s_4145[e] <=> s_0567[c] -1000.00 1000.00 0.00 r_4447 s_4146[e] <=> s_0455[c] -1000.00 1000.00 0.00 -r_4448 s_0796[e] + s_4143[e] <=> s_0794[c] + s_4144[c] -1000.00 1000.00 0.00 +r_4448 s_0796[e] + s_4143[e] <=> s_0794[c] + s_4144[c] ( YJR152W or YKR093W ) -1000.00 1000.00 0.00 r_4449 s_0794[c] + s_4144[c] <=> s_0802[v] + s_3757[v] -1000.00 1000.00 0.00 r_4450 s_0796[e] + s_4147[e] <=> s_0259[c] + s_0794[c] -1000.00 1000.00 0.00 r_4451 s_0796[e] + s_4148[e] <=> s_0782[c] + s_0794[c] -1000.00 1000.00 0.00 @@ -3818,7 +3818,7 @@ r_4453 s_4150[e] <=> s_0568[c] -1000.00 1000.00 0.00 r_4454 s_4151[e] <=> s_1545[c] -1000.00 1000.00 0.00 r_4455 s_0796[e] + s_4152[e] <=> s_0794[c] + s_1360[c] -1000.00 1000.00 0.00 r_4456 s_4153[e] <=> s_0574[c] -1000.00 1000.00 0.00 -r_4457 s_0796[e] + s_4154[e] <=> s_0794[c] + s_1239[c] -1000.00 1000.00 0.00 +r_4457 s_0796[e] + s_4154[e] <=> s_0794[c] + s_1239[c] YDR093W -1000.00 1000.00 0.00 r_4458 s_0796[e] + s_4155[e] <=> s_0340[c] + s_0794[c] -1000.00 1000.00 0.00 r_4459 s_0796[e] + s_4156[e] <=> s_0573[c] + s_0794[c] -1000.00 1000.00 0.00 r_4460 2 s_0796[e] + s_4157[e] <=> s_0633[c] + 2 s_0794[c] -1000.00 1000.00 0.00 @@ -3829,12 +3829,12 @@ r_4464 s_4161[e] <=> s_0131[c] -1000.00 1000.00 0.00 r_4465 s_0796[e] + s_4162[e] <=> s_0389[c] + s_0794[c] -1000.00 1000.00 0.00 r_4466 s_0796[e] + s_4163[e] <=> s_0526[c] + s_0794[c] -1000.00 1000.00 0.00 r_4467 s_4164[e] <=> s_3953[c] -1000.00 1000.00 0.00 -r_4468 s_4165[e] <=> s_0152[c] -1000.00 1000.00 0.00 -r_4469 s_0796[e] + s_4166[e] <=> s_0794[c] + s_0979[c] -1000.00 1000.00 0.00 +r_4468 s_4165[e] <=> s_0152[c] ( YDR342C or YHR092C ) -1000.00 1000.00 0.00 +r_4469 s_0796[e] + s_4166[e] <=> s_0794[c] + s_0979[c] YKR039W -1000.00 1000.00 0.00 r_4470 s_4167[e] <=> s_0771[c] -1000.00 1000.00 0.00 -r_4471 s_0796[e] + s_4168[e] <=> s_0794[c] + s_4169[c] -1000.00 1000.00 0.00 +r_4471 s_0796[e] + s_4168[e] <=> s_0794[c] + s_4169[c] ( YJR152W or YKR093W ) -1000.00 1000.00 0.00 r_4472 s_0794[c] + s_4169[c] <=> s_0802[v] + s_3840[v] -1000.00 1000.00 0.00 -r_4473 s_0796[e] + s_4170[e] <=> s_0794[c] + s_4171[c] -1000.00 1000.00 0.00 +r_4473 s_0796[e] + s_4170[e] <=> s_0794[c] + s_4171[c] ( YJR152W or YKR093W ) -1000.00 1000.00 0.00 r_4474 s_0794[c] + s_4171[c] <=> s_0802[v] + s_3838[v] -1000.00 1000.00 0.00 r_4475 s_4172[e] <=> s_4173[c] -1000.00 1000.00 0.00 r_4476 s_4173[c] <=> s_1192[m] -1000.00 1000.00 0.00 @@ -3854,7 +3854,7 @@ r_4489 s_0961[c] + s_1198[c] -> s_0794[c] + s_1203[c] + s_4180[c] 0.00 1000 r_4490 s_0794[c] + s_1212[c] + s_4180[c] <=> s_1207[c] + s_1566[c] -1000.00 1000.00 0.00 r_4491 s_0548[c] + s_0794[c] + s_1212[c] -> s_1207[c] + s_4181[c] 0.00 1000.00 0.00 r_4492 s_1198[c] + s_4181[c] -> s_0580[c] + s_0794[c] + s_1203[c] 0.00 1000.00 0.00 -r_4493 s_4133[e] <=> s_4132[c] -1000.00 1000.00 0.00 +r_4493 s_4133[e] <=> s_4132[c] YNL065W -1000.00 1000.00 0.00 r_4494 s_4124[e] -> 0.00 1000.00 0.00 r_4495 s_0389[c] + s_0803[c] -> s_0386[c] + s_1322[c] 0.00 1000.00 0.00 r_4496 s_4170[e] -> 0.00 1000.00 0.00 diff --git a/ModelFiles/xml/yeastGEM.xml b/ModelFiles/xml/yeastGEM.xml index 3acc245d..107ce6e4 100644 --- a/ModelFiles/xml/yeastGEM.xml +++ b/ModelFiles/xml/yeastGEM.xml @@ -67593,7 +67593,7 @@ -

Confidence Level: 0

+

Confidence Level: 3

 @@ -136037,7 +136037,7 @@ -

Confidence Level: 0

+

Confidence Level: 3

 @@ -136067,6 +136067,9 @@ + + + @@ -136785,7 +136788,7 @@ -

Confidence Level: 0

+

Confidence Level: 3

 @@ -136815,6 +136818,12 @@ + + + + + + @@ -138942,7 +138951,7 @@ -

Confidence Level: 0

+

Confidence Level: 3

 @@ -138972,6 +138981,12 @@ + + + + + + @@ -140399,7 +140414,7 @@ -

Confidence Level: 0

+

Confidence Level: 3

 @@ -140431,6 +140446,9 @@ + + + @@ -150812,7 +150830,7 @@ -

Confidence Level: 0

+

Confidence Level: 2

 @@ -150832,6 +150850,9 @@ + + + @@ -152422,7 +152443,7 @@ -

Confidence Level: 0

+

Confidence Level: 2

 @@ -152447,6 +152468,9 @@ + + + @@ -152734,7 +152758,7 @@ -

Confidence Level: 0

+

Confidence Level: 2

 @@ -152759,6 +152783,9 @@ + + + @@ -152940,7 +152967,7 @@ -

Confidence Level: 0

+

Confidence Level: 2

 @@ -153384,7 +153411,7 @@ -

Confidence Level: 0

+

Confidence Level: 2

 @@ -153409,6 +153436,12 @@ + + + + + + @@ -153947,7 +153980,7 @@ -

Confidence Level: 0

+

Confidence Level: 2

 @@ -153967,6 +154000,12 @@ + + + + + + @@ -154187,7 +154226,7 @@ -

Confidence Level: 0

+

Confidence Level: 2

 @@ -154212,6 +154251,14 @@ + + + + + + + + @@ -154238,7 +154285,7 @@ -

Confidence Level: 0

+

Confidence Level: 2

 @@ -154258,6 +154305,9 @@ + + + @@ -154523,7 +154573,7 @@ -

Confidence Level: 0

+

Confidence Level: 2

 @@ -154697,7 +154747,7 @@ -

Confidence Level: 0

+

Confidence Level: 2

 @@ -154722,6 +154772,9 @@ + + + @@ -155260,7 +155313,7 @@ -

Confidence Level: 0

+

Confidence Level: 2

 @@ -155285,6 +155338,12 @@ + + + + + + @@ -155469,7 +155528,7 @@ -

Confidence Level: 0

+

Confidence Level: 2

 @@ -155494,11 +155553,17 @@ + + + + + + -

Confidence Level: 0

+

Confidence Level: 2

 @@ -155523,11 +155588,17 @@ + + + + + + -

Confidence Level: 0

+

Confidence Level: 2

 @@ -155552,6 +155623,12 @@ + + + + + + @@ -155787,7 +155864,7 @@ -

Confidence Level: 0

+

Confidence Level: 2

 @@ -155812,6 +155889,9 @@ + + + @@ -155974,7 +156054,7 @@ -

Confidence Level: 0

+

Confidence Level: 2

 @@ -155999,11 +156079,14 @@ + + + -

Confidence Level: 0

+

Confidence Level: 2

 @@ -156164,7 +156247,7 @@ -

Confidence Level: 0

+

Confidence Level: 2

 @@ -156189,6 +156272,9 @@ + + + @@ -156294,7 +156380,7 @@ -

Confidence Level: 0

+

Confidence Level: 2

 @@ -156319,6 +156405,9 @@ + + + @@ -156842,7 +156931,7 @@ -

Confidence Level: 0

+

Confidence Level: 2

 @@ -156867,6 +156956,9 @@ + + + @@ -157840,7 +157932,7 @@ -

Confidence Level: 0

+

Confidence Level: 2

 @@ -157865,6 +157957,12 @@ + + + + + + @@ -157957,7 +158055,7 @@ -

Confidence Level: 0

+

Confidence Level: 2

 @@ -157982,6 +158080,9 @@ + + + @@ -158532,7 +158633,7 @@ -

Confidence Level: 0

+

Confidence Level: 2

 @@ -158557,11 +158658,14 @@ + + + -

Confidence Level: 0

+

Confidence Level: 2

 @@ -158586,6 +158690,14 @@ + + + + + + + + @@ -158611,7 +158723,7 @@ -

Confidence Level: 0

+

Confidence Level: 2

 @@ -158636,6 +158748,25 @@ + + + + + + + + + + + + + + + + + + + @@ -158770,7 +158901,7 @@ -

Confidence Level: 0

+

Confidence Level: 2

 @@ -158795,6 +158926,9 @@ + + + @@ -159126,7 +159260,7 @@ -

Confidence Level: 0

+

Confidence Level: 2

 @@ -159151,6 +159285,9 @@ + + + @@ -159776,7 +159913,7 @@ -

Confidence Level: 0

+

Confidence Level: 2

 @@ -159801,6 +159938,9 @@ + + + @@ -160048,7 +160188,7 @@ -

Confidence Level: 0

+

Confidence Level: 2

 @@ -160073,6 +160213,9 @@ + + + @@ -160460,7 +160603,7 @@ -

Confidence Level: 0

+

Confidence Level: 2

 @@ -160485,6 +160628,9 @@ + + + @@ -160589,7 +160735,7 @@ -

Confidence Level: 0

+

Confidence Level: 2

 @@ -160924,7 +161070,7 @@ -

Confidence Level: 0

+

Confidence Level: 2

 @@ -160949,11 +161095,14 @@ + + + -

Confidence Level: 0

+

Confidence Level: 2

 @@ -160978,6 +161127,12 @@ + + + + + + @@ -161053,7 +161208,7 @@ -

Confidence Level: 0

+

Confidence Level: 2

 @@ -161078,6 +161233,9 @@ + + + @@ -161448,7 +161606,7 @@ -

Confidence Level: 0

+

Confidence Level: 2

 @@ -161686,7 +161844,7 @@ -

Confidence Level: 0

+

Confidence Level: 2

 @@ -161711,6 +161869,9 @@ + + + @@ -162114,7 +162275,7 @@ -

Confidence Level: 0

+

Confidence Level: 2

 @@ -162139,6 +162300,12 @@ + + + + + + @@ -162410,7 +162577,7 @@ -

Confidence Level: 0

+

Confidence Level: 2

 @@ -162435,6 +162602,12 @@ + + + + + + @@ -162460,7 +162633,7 @@ -

Confidence Level: 0

+

Confidence Level: 2

 @@ -162485,6 +162658,12 @@ + + + + + + @@ -162865,7 +163044,7 @@ -

Confidence Level: 0

+

Confidence Level: 2

 @@ -162885,11 +163064,14 @@ + + + -

Confidence Level: 0

+

Confidence Level: 2

 @@ -162914,6 +163096,9 @@ + + + @@ -163021,7 +163206,7 @@ -

Confidence Level: 0

+

Confidence Level: 2

 @@ -163046,6 +163231,12 @@ + + + + + + @@ -164161,7 +164352,7 @@ -

Confidence Level: 0

+

Confidence Level: 2

 @@ -164186,6 +164377,12 @@ + + + + + + @@ -164707,7 +164904,7 @@ -

Confidence Level: 0

+

Confidence Level: 2

 @@ -164732,6 +164929,9 @@ + + + @@ -166273,7 +166473,7 @@ -

Confidence Level: 0

+

Confidence Level: 2

 @@ -166298,11 +166498,18 @@ + + + + + + + -

Confidence Level: 0

+

Confidence Level: 2

 @@ -166327,11 +166534,18 @@ + + + + + + + -

Confidence Level: 0

+

Confidence Level: 2

 @@ -166356,11 +166570,14 @@ + + + -

Confidence Level: 0

+

Confidence Level: 2

 @@ -166385,6 +166602,9 @@ + + + @@ -167403,7 +167623,7 @@ -

Confidence Level: 0

+

Confidence Level: 2

 @@ -167428,6 +167648,9 @@ + + + @@ -168227,7 +168450,7 @@ -

Confidence Level: 0

+

Confidence Level: 2

 @@ -168252,6 +168475,9 @@ + + + @@ -171464,7 +171690,7 @@ -

Confidence Level: 0

+

Confidence Level: 2

 @@ -171484,11 +171710,17 @@ + + + + + + -

Confidence Level: 0

+

Confidence Level: 2

 @@ -171508,11 +171740,17 @@ + + + + + + -

Confidence Level: 0

+

Confidence Level: 2

 @@ -171532,11 +171770,17 @@ + + + + + + -

Confidence Level: 0

+

Confidence Level: 2

 @@ -171556,11 +171800,17 @@ + + + + + + -

Confidence Level: 0

+

Confidence Level: 2

 @@ -171580,11 +171830,17 @@ + + + + + + -

Confidence Level: 0

+

Confidence Level: 2

 @@ -171604,11 +171860,17 @@ + + + + + + -

Confidence Level: 0

+

Confidence Level: 2

 @@ -171628,11 +171890,17 @@ + + + + + + -

Confidence Level: 0

+

Confidence Level: 2

 @@ -171652,11 +171920,17 @@ + + + + + + -

Confidence Level: 0

+

Confidence Level: 2

 @@ -171676,11 +171950,14 @@ + + + -

Confidence Level: 0

+

Confidence Level: 2

 @@ -171700,11 +171977,14 @@ + + + -

Confidence Level: 0

+

Confidence Level: 2

 @@ -171724,11 +172004,14 @@ + + + -

Confidence Level: 0

+

Confidence Level: 2

 @@ -171748,11 +172031,14 @@ + + + -

Confidence Level: 0

+

Confidence Level: 2

 @@ -171772,11 +172058,14 @@ + + + -

Confidence Level: 0

+

Confidence Level: 2

 @@ -171796,11 +172085,14 @@ + + + -

Confidence Level: 0

+

Confidence Level: 2

 @@ -171820,11 +172112,14 @@ + + + -

Confidence Level: 0

+

Confidence Level: 2

 @@ -171844,6 +172139,9 @@ + + + @@ -173192,7 +173490,7 @@ -

Confidence Level: 0

+

Confidence Level: 2

 @@ -173212,11 +173510,14 @@ + + + -

Confidence Level: 0

+

Confidence Level: 2

 @@ -173236,11 +173537,14 @@ + + + -

Confidence Level: 0

+

Confidence Level: 2

 @@ -173260,11 +173564,14 @@ + + + -

Confidence Level: 0

+

Confidence Level: 2

 @@ -173284,11 +173591,14 @@ + + + -

Confidence Level: 0

+

Confidence Level: 2

 @@ -173308,11 +173618,14 @@ + + + -

Confidence Level: 0

+

Confidence Level: 2

 @@ -173332,11 +173645,14 @@ + + + -

Confidence Level: 0

+

Confidence Level: 2

 @@ -173356,11 +173672,14 @@ + + + -

Confidence Level: 0

+

Confidence Level: 2

 @@ -173380,11 +173699,14 @@ + + + -

Confidence Level: 0

+

Confidence Level: 2

 @@ -173404,11 +173726,14 @@ + + + -

Confidence Level: 0

+

Confidence Level: 2

 @@ -173428,11 +173753,14 @@ + + + -

Confidence Level: 0

+

Confidence Level: 2

 @@ -173452,11 +173780,14 @@ + + + -

Confidence Level: 0

+

Confidence Level: 2

 @@ -173476,11 +173807,14 @@ + + + -

Confidence Level: 0

+

Confidence Level: 2

 @@ -173500,11 +173834,14 @@ + + + -

Confidence Level: 0

+

Confidence Level: 2

 @@ -173524,11 +173861,14 @@ + + + -

Confidence Level: 0

+

Confidence Level: 2

 @@ -173548,11 +173888,14 @@ + + + -

Confidence Level: 0

+

Confidence Level: 2

 @@ -173572,6 +173915,9 @@ + + + @@ -175008,7 +175354,7 @@ -

Confidence Level: 0

+

Confidence Level: 2

 @@ -175033,11 +175379,14 @@ + + + -

Confidence Level: 0

+

Confidence Level: 2

 @@ -175062,11 +175411,14 @@ + + + -

Confidence Level: 0

+

Confidence Level: 2

 @@ -175091,6 +175443,13 @@ + + + + + + + @@ -185802,7 +186161,7 @@ -

Confidence Level: 1

+

Confidence Level: 2

NOTES: added after the Biolog update (PR #149); seed:rxn12552;Gly-Met_N Source

 @@ -185830,6 +186189,12 @@ + + + + + + @@ -186638,7 +187003,7 @@ -

Confidence Level: 1

+

Confidence Level: 2

NOTES: added after the Biolog update (PR #149); seed:rxn12628;Ala-Asp_N Source

 @@ -186666,6 +187031,12 @@ + + + + + + @@ -186889,7 +187260,7 @@ -

Confidence Level: 1

+

Confidence Level: 2

NOTES: added after the Biolog update (PR #149); bigg:TAGAT_Dt;D-tagatose_C Source

 @@ -186915,6 +187286,25 @@ + + + + + + + + + + + + + + + + + + + @@ -186988,7 +187378,7 @@ -

Confidence Level: 1

+

Confidence Level: 2

NOTES: added after the Biolog update (PR #149); seed:rxn12568;Ala-Gln_N Source

 @@ -187016,6 +187406,12 @@ + + + + + + @@ -187112,7 +187508,7 @@ -

Confidence Level: 1

+

Confidence Level: 2

NOTES: added after the Biolog update (PR #149); Ala-Thr_N Source

 @@ -187135,11 +187531,17 @@ + + + + + + -

Confidence Level: 1

+

Confidence Level: 2

NOTES: added after the Biolog update (PR #149); rhea:14157;triphosphate_P Source

 @@ -187179,7 +187581,7 @@ -

Confidence Level: 1

+

Confidence Level: 2

NOTES: added after the Biolog update (PR #149); Gly-Asn_N Source

 @@ -187202,6 +187604,12 @@ + + + + + + @@ -187297,7 +187705,7 @@ -

Confidence Level: 1

+

Confidence Level: 2

NOTES: added after the Biolog update (PR #149); rhea:35131;Ala-Glu_N Source

 @@ -187325,6 +187733,12 @@ + + + + + + @@ -187822,7 +188236,7 @@ -

Confidence Level: 1

+

Confidence Level: 2

NOTES: added after the Biolog update (PR #149); seed:rxn12555;Gly-Gln_N Source

 @@ -187850,6 +188264,12 @@ + + + + + + @@ -187982,7 +188402,7 @@ -

Confidence Level: 1

+

Confidence Level: 2

NOTES: added after the Biolog update (PR #149); seed:rxn12594;Ala-His_N Source

 @@ -188010,6 +188430,12 @@ + + + + + + @@ -188165,7 +188591,7 @@ -

Confidence Level: 1

+

Confidence Level: 2

NOTES: added after the Biolog update (PR #149); glycerol 1-phosphate_P Source

 @@ -188231,7 +188657,7 @@ -

Confidence Level: 1

+

Confidence Level: 2

NOTES: added after the Biolog update (PR #149); Gly-Glu_N Source

 @@ -188254,6 +188680,12 @@ + + + + + + @@ -188368,7 +188800,7 @@ -

Confidence Level: 1

+

Confidence Level: NaN

NOTES: added after the Biolog update (PR #149); cysteamine S-phosphate_P Source

 @@ -188544,7 +188976,7 @@ -

Confidence Level: 1

+

Confidence Level: 2

NOTES: added after the Biolog update (PR #149); Met-Ala_N Source

 @@ -188567,6 +188999,12 @@ + + + + + + @@ -188814,7 +189252,7 @@ -

Confidence Level: 1

+

Confidence Level: 2

NOTES: added after the Biolog update (PR #149); seed:rxn05716;O-phosphoethanolamine_P Source

 @@ -188842,6 +189280,9 @@ + + + @@ -189158,7 +189599,7 @@ -

Confidence Level: 1

+

Confidence Level: 2

NOTES: added after the Biolog update (PR #149); 2-deoxy-D-ribose_C Source

 @@ -189179,11 +189620,17 @@ + + + + + + -

Confidence Level: 1

+

Confidence Level: 2

NOTES: added after the Biolog update (PR #149); seed:rxn05674;L-citrulline_N Source

 @@ -189211,6 +189658,9 @@ + + + @@ -189245,7 +189695,7 @@ -

Confidence Level: 1

+

Confidence Level: 2

NOTES: added after the Biolog update (PR #149); Ala-Leu_N Source

 @@ -189268,6 +189718,12 @@ + + + + + + @@ -189299,7 +189755,7 @@ -

Confidence Level: 1

+

Confidence Level: 2

NOTES: added after the Biolog update (PR #149); seed:rxn12625;Ala-Gly_N Source

 @@ -189327,6 +189783,12 @@ + + + + + + @@ -189625,7 +190087,7 @@ -

Confidence Level: 1

+

Confidence Level: 2

NOTES: added after the Biolog update (PR #149); rhea:27826;L-methionine_N Source

 @@ -189935,7 +190397,7 @@ -

Confidence Level: 1

+

Confidence Level: 2

NOTES: added after the Biolog update (PR #149); rhea:29751;acetoacetate_C Source

 @@ -189961,11 +190423,14 @@ + + + -

Confidence Level: 1

+

Confidence Level: NaN

NOTES: added after the Biolog update (PR #149); bigg:EX_meoh_e;methyl alpha-D-glucopyranoside_C Source

 @@ -193846,6 +194311,17 @@ + + + + + + + + + + + diff --git a/ModelFiles/yml/yeastGEM.yml b/ModelFiles/yml/yeastGEM.yml index 66e65ad7..b66c1962 100644 --- a/ModelFiles/yml/yeastGEM.yml +++ b/ModelFiles/yml/yeastGEM.yml @@ -35294,7 +35294,7 @@ - metanetx.reaction: MNXR100030 - pmid: 3309138 - sbo: SBO:0000176 - - confidence_score: 0 + - confidence_score: 3 - !!omap - id: r_0476 - name: glutamine synthetase @@ -46394,11 +46394,12 @@ - s_0684: -1 - lower_bound: -1000 - upper_bound: 1000 + - gene_reaction_rule: YGL077C - annotation: !!omap - metanetx.reaction: MNXR97974 - pmid: 15201274 - sbo: SBO:0000655 - - confidence_score: 0 + - confidence_score: 3 - !!omap - id: r_1151 - name: fadH2 transport @@ -46671,11 +46672,12 @@ - s_0926: 1 - lower_bound: 0 - upper_bound: 1000 + - gene_reaction_rule: YJL133W or YKR052C - annotation: !!omap - metanetx.reaction: MNXR99505 - pmid: 9660806 - sbo: SBO:0000655 - - confidence_score: 0 + - confidence_score: 3 - !!omap - id: r_1180 - name: isoamyl acetate transport @@ -47511,11 +47513,12 @@ - s_1451: 1 - lower_bound: -1000 - upper_bound: 1000 + - gene_reaction_rule: YKL188C and YPL147W - annotation: !!omap - metanetx.reaction: MNXR99109 - pmid: 8993619 - sbo: SBO:0000655 - - confidence_score: 0 + - confidence_score: 3 - !!omap - id: r_1237 - name: ornithine transport @@ -48699,9 +48702,10 @@ - s_0164: 1 - lower_bound: -1000 - upper_bound: 1000 + - gene_reaction_rule: YKL120W - annotation: !!omap - sbo: SBO:0000655 - - confidence_score: 0 + - confidence_score: 2 - !!omap - id: r_1575 - name: 2-methyl-1-butanol transport @@ -49401,10 +49405,11 @@ - s_0392: 1 - lower_bound: -1000 - upper_bound: 1000 + - gene_reaction_rule: YPR011C - annotation: !!omap - metanetx.reaction: MNXR102382 - sbo: SBO:0000655 - - confidence_score: 0 + - confidence_score: 2 - !!omap - id: r_1643 - name: adenosine exchange @@ -49532,11 +49537,12 @@ - s_0967: 1 - lower_bound: 0 - upper_bound: 1000 + - gene_reaction_rule: YBR147W - annotation: !!omap - metanetx.reaction: MNXR95953 - pmid: 9874237 - sbo: SBO:0000655 - - confidence_score: 0 + - confidence_score: 3 - !!omap - id: r_1658 - name: asparagine transport @@ -49545,10 +49551,11 @@ - s_0971: 1 - lower_bound: 0 - upper_bound: 1000 + - gene_reaction_rule: YDR508C - annotation: !!omap - metanetx.reaction: MNXR96069 - sbo: SBO:0000655 - - confidence_score: 0 + - confidence_score: 2 - !!omap - id: r_1659 - name: aspartate-glutamate transporter @@ -49639,7 +49646,7 @@ - annotation: !!omap - metanetx.reaction: MNXR100482 - sbo: SBO:0000176 - - confidence_score: 0 + - confidence_score: 2 - !!omap - id: r_1668 - name: bicarbonate formation @@ -49826,10 +49833,11 @@ - s_0512: 1 - lower_bound: -1000 - upper_bound: 1000 + - gene_reaction_rule: YGL077C or YOR161C - annotation: !!omap - metanetx.reaction: MNXR96693 - sbo: SBO:0000655 - - confidence_score: 0 + - confidence_score: 2 - !!omap - id: r_1685 - name: chorismate pyruvate lyase @@ -50065,9 +50073,10 @@ - s_0549: -1 - lower_bound: -1000 - upper_bound: 1000 + - gene_reaction_rule: YDR342C or YHR092C - annotation: !!omap - sbo: SBO:0000655 - - confidence_score: 0 + - confidence_score: 2 - !!omap - id: r_1708 - name: D-erythrose 4-phosphate transport @@ -50164,10 +50173,11 @@ - s_0562: -1 - lower_bound: -1000 - upper_bound: 1000 + - gene_reaction_rule: YDL245C or YEL069C or YJR158W or YNR072W - annotation: !!omap - metanetx.reaction: MNXR104288 - sbo: SBO:0000655 - - confidence_score: 0 + - confidence_score: 2 - !!omap - id: r_1718 - name: D-xylose exchange @@ -50185,9 +50195,10 @@ - s_0579: -1 - lower_bound: -1000 - upper_bound: 1000 + - gene_reaction_rule: YHR092C - annotation: !!omap - sbo: SBO:0000655 - - confidence_score: 0 + - confidence_score: 2 - !!omap - id: r_1720 - name: dADP transport @@ -50318,7 +50329,7 @@ - annotation: !!omap - metanetx.reaction: MNXR96117 - sbo: SBO:0000176 - - confidence_score: 0 + - confidence_score: 2 - !!omap - id: r_1730 - name: deoxycytidine exchange @@ -50387,10 +50398,11 @@ - s_0139: -1 - lower_bound: 0 - upper_bound: 1000 + - gene_reaction_rule: YBL042C - annotation: !!omap - metanetx.reaction: MNXR97819 - sbo: SBO:0000655 - - confidence_score: 0 + - confidence_score: 2 - !!omap - id: r_1736 - name: dephospho-CoA kinase @@ -50627,10 +50639,11 @@ - s_0666: -1 - lower_bound: -1000 - upper_bound: 1000 + - gene_reaction_rule: YIL013C or YOR011W - annotation: !!omap - metanetx.reaction: MNXR97950 - sbo: SBO:0000655 - - confidence_score: 0 + - confidence_score: 2 - !!omap - id: r_1761 - name: ethanol exchange @@ -50714,10 +50727,11 @@ - s_1070: 1 - lower_bound: -1000 - upper_bound: 1000 + - gene_reaction_rule: YKL188C and YPL147W - annotation: !!omap - metanetx.reaction: MNXR135773 - sbo: SBO:0000655 - - confidence_score: 0 + - confidence_score: 2 - !!omap - id: r_1772 - name: fatty acid transport @@ -50726,10 +50740,11 @@ - s_1166: 1 - lower_bound: -1000 - upper_bound: 1000 + - gene_reaction_rule: YKL188C and YPL147W - annotation: !!omap - metanetx.reaction: MNXR128297 - sbo: SBO:0000655 - - confidence_score: 0 + - confidence_score: 2 - !!omap - id: r_1774 - name: fatty acid transport @@ -50738,10 +50753,11 @@ - s_1291: 1 - lower_bound: -1000 - upper_bound: 1000 + - gene_reaction_rule: YKL188C and YPL147W - annotation: !!omap - metanetx.reaction: MNXR99101 - sbo: SBO:0000655 - - confidence_score: 0 + - confidence_score: 2 - !!omap - id: r_1775 - name: fatty acid transport @@ -50849,10 +50865,11 @@ - s_0723: -1 - lower_bound: -1000 - upper_bound: 1000 + - gene_reaction_rule: YNL065W - annotation: !!omap - metanetx.reaction: MNXR99620 - sbo: SBO:0000655 - - confidence_score: 0 + - confidence_score: 2 - !!omap - id: r_1796 - name: formate transport @@ -50929,10 +50946,11 @@ - s_0744: 1 - lower_bound: -1000 - upper_bound: 1000 + - gene_reaction_rule: YGL225W - annotation: !!omap - metanetx.reaction: MNXR131177 - sbo: SBO:0000655 - - confidence_score: 0 + - confidence_score: 2 - !!omap - id: r_1805 - name: glucose transport, vacuolar @@ -50945,7 +50963,7 @@ - annotation: !!omap - metanetx.reaction: MNXR100188 - sbo: SBO:0000655 - - confidence_score: 0 + - confidence_score: 2 - !!omap - id: r_1806 - name: glutathione disulfide exchange @@ -51004,10 +51022,11 @@ - s_1005: 1 - lower_bound: -1000 - upper_bound: 1000 + - gene_reaction_rule: YPR058W - annotation: !!omap - metanetx.reaction: MNXR100371 - sbo: SBO:0000655 - - confidence_score: 0 + - confidence_score: 2 - !!omap - id: r_1812 - name: glycoaldehyde transport @@ -51058,10 +51077,11 @@ - s_0780: 1 - lower_bound: -1000 - upper_bound: 1000 + - gene_reaction_rule: YNL065W - annotation: !!omap - metanetx.reaction: MNXR100306 - sbo: SBO:0000655 - - confidence_score: 0 + - confidence_score: 2 - !!omap - id: r_1817 - name: glyoxylate transport @@ -51288,10 +51308,11 @@ - s_1008: 1 - lower_bound: 0 - upper_bound: 1000 + - gene_reaction_rule: YBR147W - annotation: !!omap - metanetx.reaction: MNXR100649 - sbo: SBO:0000655 - - confidence_score: 0 + - confidence_score: 2 - !!omap - id: r_1838 - name: homocitrate synthase @@ -51743,10 +51764,11 @@ - s_0964: -1 - lower_bound: -1000 - upper_bound: 1000 + - gene_reaction_rule: YDR342C or YHR092C - annotation: !!omap - metanetx.reaction: MNXR135734 - sbo: SBO:0000655 - - confidence_score: 0 + - confidence_score: 2 - !!omap - id: r_1878 - name: L-arabinose exchange @@ -51791,10 +51813,11 @@ - s_0023: -1 - lower_bound: 0 - upper_bound: 1000 + - gene_reaction_rule: YOR100C - annotation: !!omap - metanetx.reaction: MNXR96906 - sbo: SBO:0000655 - - confidence_score: 0 + - confidence_score: 2 - !!omap - id: r_1883 - name: L-cysteine exchange @@ -52030,10 +52053,11 @@ - s_1040: 1 - lower_bound: -1000 - upper_bound: 1000 + - gene_reaction_rule: YKR039W - annotation: !!omap - metanetx.reaction: MNXR104354 - sbo: SBO:0000655 - - confidence_score: 0 + - confidence_score: 2 - !!omap - id: r_1908 - name: L-sorbitol transport @@ -52042,10 +52066,11 @@ - s_0990: -1 - lower_bound: -1000 - upper_bound: 1000 + - gene_reaction_rule: YDL245C or YEL069C or YJR158W or YNR072W - annotation: !!omap - metanetx.reaction: MNXR104289 - sbo: SBO:0000655 - - confidence_score: 0 + - confidence_score: 2 - !!omap - id: r_1909 - name: L-sorbose exchange @@ -52063,10 +52088,11 @@ - s_1044: -1 - lower_bound: -1000 - upper_bound: 1000 + - gene_reaction_rule: YDL245C or YDR342C or YDR343C or YDR345C or YEL069C or YFL011W or YHR092C or YHR094C or YHR096C or YJL214W or YJL219W or YJR158W or YMR011W or YNR072W or YOL156W - annotation: !!omap - metanetx.reaction: MNXR104533 - sbo: SBO:0000655 - - confidence_score: 0 + - confidence_score: 2 - !!omap - id: r_1911 - name: L-threonine exchange @@ -52129,10 +52155,11 @@ - s_1027: 1 - lower_bound: 0 - upper_bound: 1000 + - gene_reaction_rule: YBR147W - annotation: !!omap - metanetx.reaction: MNXR101269 - sbo: SBO:0000655 - - confidence_score: 0 + - confidence_score: 2 - !!omap - id: r_1920 - name: M(IP)2C transport @@ -52287,10 +52314,11 @@ - s_1031: -1 - lower_bound: 0 - upper_bound: 1000 + - gene_reaction_rule: YDR508C - annotation: !!omap - metanetx.reaction: MNXR101493 - sbo: SBO:0000655 - - confidence_score: 0 + - confidence_score: 2 - !!omap - id: r_1936 - name: methylglyoxal synthase @@ -52572,10 +52600,11 @@ - s_1236: 1 - lower_bound: 0 - upper_bound: 1000 + - gene_reaction_rule: YOR100C - annotation: !!omap - metanetx.reaction: MNXR95412 - sbo: SBO:0000655 - - confidence_score: 0 + - confidence_score: 2 - !!omap - id: r_1977 - name: O2 transport @@ -52684,10 +52713,11 @@ - s_0755: -1 - lower_bound: 0 - upper_bound: 1000 + - gene_reaction_rule: YJL212C - annotation: !!omap - metanetx.reaction: MNXR100443 - sbo: SBO:0000655 - - confidence_score: 0 + - confidence_score: 2 - !!omap - id: r_1991 - name: oxidized thioredoxin transport @@ -52858,10 +52888,11 @@ - s_1329: 1 - lower_bound: -1000 - upper_bound: 1000 + - gene_reaction_rule: YNR013C - annotation: !!omap - metanetx.reaction: MNXR102871 - sbo: SBO:0000655 - - confidence_score: 0 + - confidence_score: 2 - !!omap - id: r_2020 - name: potassium exchange @@ -52919,7 +52950,7 @@ - annotation: !!omap - metanetx.reaction: MNXR103361 - sbo: SBO:0000176 - - confidence_score: 0 + - confidence_score: 2 - !!omap - id: r_2026 - name: pyridoxamine kinase @@ -53093,10 +53124,11 @@ - s_1406: -1 - lower_bound: 0 - upper_bound: 1000 + - gene_reaction_rule: YOR306C - annotation: !!omap - metanetx.reaction: MNXR104033 - sbo: SBO:0000655 - - confidence_score: 0 + - confidence_score: 2 - !!omap - id: r_2041 - name: ribose transporter @@ -53105,10 +53137,11 @@ - s_0576: -1 - lower_bound: 0 - upper_bound: 1000 + - gene_reaction_rule: YDR342C or YHR092C - annotation: !!omap - metanetx.reaction: MNXR104036 - sbo: SBO:0000655 - - confidence_score: 0 + - confidence_score: 2 - !!omap - id: r_2042 - name: S-adenosyl-L-homocysteine transport @@ -53147,10 +53180,11 @@ - s_1042: 1 - lower_bound: -1000 - upper_bound: 1000 + - gene_reaction_rule: YDR508C - annotation: !!omap - metanetx.reaction: MNXR104354 - sbo: SBO:0000655 - - confidence_score: 0 + - confidence_score: 2 - !!omap - id: r_2046 - name: sn-glycero-3-phosphocholine exchange @@ -53319,7 +53353,7 @@ - annotation: !!omap - metanetx.reaction: MNXR104823 - sbo: SBO:0000176 - - confidence_score: 0 + - confidence_score: 2 - !!omap - id: r_2065 - name: thiaminase @@ -53428,10 +53462,11 @@ - s_1047: 1 - lower_bound: 0 - upper_bound: 1000 + - gene_reaction_rule: YDR508C - annotation: !!omap - metanetx.reaction: MNXR104852 - sbo: SBO:0000655 - - confidence_score: 0 + - confidence_score: 2 - !!omap - id: r_2073 - name: thymidine exchange @@ -53624,10 +53659,11 @@ - s_0804: 1 - lower_bound: -1000 - upper_bound: 1000 + - gene_reaction_rule: YLL052C or YPR192W - annotation: !!omap - metanetx.reaction: MNXR98641 - sbo: SBO:0000655 - - confidence_score: 0 + - confidence_score: 2 - !!omap - id: r_2095 - name: water diffusion @@ -53747,10 +53783,11 @@ - s_1567: -1 - lower_bound: -1000 - upper_bound: 1000 + - gene_reaction_rule: YDL245C or YLL043W - annotation: !!omap - metanetx.reaction: MNXR105264 - sbo: SBO:0000655 - - confidence_score: 0 + - confidence_score: 2 - !!omap - id: r_2106 - name: zymosterol exchange @@ -53768,10 +53805,11 @@ - s_1569: 1 - lower_bound: -1000 - upper_bound: 1000 + - gene_reaction_rule: YIL013C or YOR011W - annotation: !!omap - metanetx.reaction: MNXR105285 - sbo: SBO:0000655 - - confidence_score: 0 + - confidence_score: 2 - !!omap - id: r_2108 - name: lipid pseudoreaction - merge @@ -55149,9 +55187,10 @@ - s_2828: 1 - lower_bound: -1000 - upper_bound: 1000 + - gene_reaction_rule: YNL065W - annotation: !!omap - sbo: SBO:0000655 - - confidence_score: 0 + - confidence_score: 2 - !!omap - id: r_2191 - name: hexanoate (n-C6:0) transport @@ -55160,10 +55199,11 @@ - s_2829: 1 - lower_bound: -1000 - upper_bound: 1000 + - gene_reaction_rule: YNL065W - annotation: !!omap - metanetx.reaction: MNXR100750 - sbo: SBO:0000655 - - confidence_score: 0 + - confidence_score: 2 - !!omap - id: r_2192 - name: octadecenoate (n-C18:1) transport @@ -55988,10 +56028,11 @@ - s_2855: 1 - lower_bound: -1000 - upper_bound: 1000 + - gene_reaction_rule: YKL188C and YPL147W - annotation: !!omap - metanetx.reaction: MNXR99110 - sbo: SBO:0000655 - - confidence_score: 0 + - confidence_score: 2 - !!omap - id: r_2232 - name: peroxisomal acyl-CoA thioesterase (4:0) @@ -80112,10 +80153,11 @@ - s_2808: 1 - lower_bound: -1000 - upper_bound: 1000 + - gene_reaction_rule: YLL052C or YPR192W - annotation: !!omap - metanetx.reaction: MNXR98641 - sbo: SBO:0000655 - - confidence_score: 0 + - confidence_score: 2 - !!omap - id: r_3527 - name: CO2 transport, cytoplasm-ER membrane @@ -80339,10 +80381,11 @@ - s_3107: 1 - lower_bound: -1000 - upper_bound: 1000 + - gene_reaction_rule: YKR039W - annotation: !!omap - metanetx.reaction: MNXR104354 - sbo: SBO:0000655 - - confidence_score: 0 + - confidence_score: 2 - !!omap - id: r_3546 - name: myo-inositol transport, cytoplasm-ER membrane @@ -81018,10 +81061,11 @@ - s_3449: 1 - lower_bound: -1000 - upper_bound: 1000 + - gene_reaction_rule: YLL052C or YLL053C or YPR192W - annotation: !!omap - metanetx.reaction: MNXR98641 - sbo: SBO:0000655 - - confidence_score: 0 + - confidence_score: 2 - !!omap - id: r_3605 - name: phosphate transport, cytoplasm-cell envelope @@ -81030,10 +81074,11 @@ - s_3536: 1 - lower_bound: -1000 - upper_bound: 1000 + - gene_reaction_rule: YCR037C or YJL198W or YML123C - annotation: !!omap - metanetx.reaction: MNXR102871 - sbo: SBO:0000655 - - confidence_score: 0 + - confidence_score: 2 - !!omap - id: r_3606 - name: sn-glycero-3-phosphocholine transport, cell envelope-cytoplasm @@ -81042,10 +81087,11 @@ - s_1433: 1 - lower_bound: -1000 - upper_bound: 1000 + - gene_reaction_rule: YCR098C - annotation: !!omap - metanetx.reaction: MNXR99874 - sbo: SBO:0000655 - - confidence_score: 0 + - confidence_score: 2 - !!omap - id: r_3607 - name: 1-(sn-glycero-3-phospho)-1D-myo-inositol transport, cell envelope-cytoplasm @@ -81054,10 +81100,11 @@ - s_3495: -1 - lower_bound: -1000 - upper_bound: 1000 + - gene_reaction_rule: YCR098C - annotation: !!omap - metanetx.reaction: MNXR99888 - sbo: SBO:0000655 - - confidence_score: 0 + - confidence_score: 2 - !!omap - id: r_3608 - name: palmitate transport, cell envelope-cytoplasm @@ -81523,10 +81570,11 @@ - s_2977: 1 - lower_bound: -1000 - upper_bound: 1000 + - gene_reaction_rule: YNR013C - annotation: !!omap - metanetx.reaction: MNXR102871 - sbo: SBO:0000655 - - confidence_score: 0 + - confidence_score: 2 - !!omap - id: r_3650 - name: H+ transport, cytoplasm-vacuolar membrane @@ -81880,10 +81928,11 @@ - s_3321: -1 - lower_bound: -1000 - upper_bound: 1000 + - gene_reaction_rule: YHR002W - annotation: !!omap - metanetx.reaction: MNXR96815 - sbo: SBO:0000655 - - confidence_score: 0 + - confidence_score: 2 - !!omap - id: r_3681 - name: laurate transport, ER membrane-lipid particle @@ -83352,9 +83401,10 @@ - s_3145: 1 - lower_bound: -1000 - upper_bound: 1000 + - gene_reaction_rule: YIL048W or YMR162C - annotation: !!omap - sbo: SBO:0000655 - - confidence_score: 0 + - confidence_score: 2 - !!omap - id: r_3814 - name: phosphatidyl-L-serine (1-16:1, 2-16:1) transport, ER membrane-Golgi membrane @@ -83363,9 +83413,10 @@ - s_3149: 1 - lower_bound: -1000 - upper_bound: 1000 + - gene_reaction_rule: YIL048W or YMR162C - annotation: !!omap - sbo: SBO:0000655 - - confidence_score: 0 + - confidence_score: 2 - !!omap - id: r_3815 - name: phosphatidyl-L-serine (1-18:0, 2-16:1) transport, ER membrane-Golgi membrane @@ -83374,9 +83425,10 @@ - s_3151: 1 - lower_bound: -1000 - upper_bound: 1000 + - gene_reaction_rule: YIL048W or YMR162C - annotation: !!omap - sbo: SBO:0000655 - - confidence_score: 0 + - confidence_score: 2 - !!omap - id: r_3816 - name: phosphatidyl-L-serine (1-18:1, 2-16:1) transport, ER membrane-Golgi membrane @@ -83385,9 +83437,10 @@ - s_3153: 1 - lower_bound: -1000 - upper_bound: 1000 + - gene_reaction_rule: YIL048W or YMR162C - annotation: !!omap - sbo: SBO:0000655 - - confidence_score: 0 + - confidence_score: 2 - !!omap - id: r_3817 - name: phosphatidyl-L-serine (1-16:0, 2-18:1) transport, ER membrane-Golgi membrane @@ -83396,9 +83449,10 @@ - s_3155: 1 - lower_bound: -1000 - upper_bound: 1000 + - gene_reaction_rule: YIL048W or YMR162C - annotation: !!omap - sbo: SBO:0000655 - - confidence_score: 0 + - confidence_score: 2 - !!omap - id: r_3818 - name: phosphatidyl-L-serine (1-16:1, 2-18:1) transport, ER membrane-Golgi membrane @@ -83407,9 +83461,10 @@ - s_3157: 1 - lower_bound: -1000 - upper_bound: 1000 + - gene_reaction_rule: YIL048W or YMR162C - annotation: !!omap - sbo: SBO:0000655 - - confidence_score: 0 + - confidence_score: 2 - !!omap - id: r_3819 - name: phosphatidyl-L-serine (1-18:0, 2-18:1) transport, ER membrane-Golgi membrane @@ -83418,9 +83473,10 @@ - s_3159: 1 - lower_bound: -1000 - upper_bound: 1000 + - gene_reaction_rule: YIL048W or YMR162C - annotation: !!omap - sbo: SBO:0000655 - - confidence_score: 0 + - confidence_score: 2 - !!omap - id: r_3820 - name: phosphatidyl-L-serine (1-18:1, 2-18:1) transport, ER membrane-Golgi membrane @@ -83429,9 +83485,10 @@ - s_3161: 1 - lower_bound: -1000 - upper_bound: 1000 + - gene_reaction_rule: YIL048W or YMR162C - annotation: !!omap - sbo: SBO:0000655 - - confidence_score: 0 + - confidence_score: 2 - !!omap - id: r_3821 - name: phosphatidylethanolamine (1-16:0, 2-16:1) transport, Golgi membrane-ER membrane @@ -83440,9 +83497,10 @@ - s_3181: 1 - lower_bound: -1000 - upper_bound: 1000 + - gene_reaction_rule: YAL026C - annotation: !!omap - sbo: SBO:0000655 - - confidence_score: 0 + - confidence_score: 2 - !!omap - id: r_3822 - name: phosphatidylethanolamine (1-16:1, 2-16:1) transport, Golgi membrane-ER membrane @@ -83451,9 +83509,10 @@ - s_3185: 1 - lower_bound: -1000 - upper_bound: 1000 + - gene_reaction_rule: YAL026C - annotation: !!omap - sbo: SBO:0000655 - - confidence_score: 0 + - confidence_score: 2 - !!omap - id: r_3823 - name: phosphatidylethanolamine (1-18:0, 2-16:1) transport, Golgi membrane-ER membrane @@ -83462,9 +83521,10 @@ - s_3187: 1 - lower_bound: -1000 - upper_bound: 1000 + - gene_reaction_rule: YAL026C - annotation: !!omap - sbo: SBO:0000655 - - confidence_score: 0 + - confidence_score: 2 - !!omap - id: r_3824 - name: phosphatidylethanolamine (1-18:1, 2-16:1) transport, Golgi membrane-ER membrane @@ -83473,9 +83533,10 @@ - s_3189: 1 - lower_bound: -1000 - upper_bound: 1000 + - gene_reaction_rule: YAL026C - annotation: !!omap - sbo: SBO:0000655 - - confidence_score: 0 + - confidence_score: 2 - !!omap - id: r_3825 - name: phosphatidylethanolamine (1-16:0, 2-18:1) transport, Golgi membrane-ER membrane @@ -83484,9 +83545,10 @@ - s_3191: 1 - lower_bound: -1000 - upper_bound: 1000 + - gene_reaction_rule: YAL026C - annotation: !!omap - sbo: SBO:0000655 - - confidence_score: 0 + - confidence_score: 2 - !!omap - id: r_3826 - name: phosphatidylethanolamine (1-16:1, 2-18:1) transport, Golgi membrane-ER membrane @@ -83495,9 +83557,10 @@ - s_3193: 1 - lower_bound: -1000 - upper_bound: 1000 + - gene_reaction_rule: YAL026C - annotation: !!omap - sbo: SBO:0000655 - - confidence_score: 0 + - confidence_score: 2 - !!omap - id: r_3827 - name: phosphatidylethanolamine (1-18:0, 2-18:1) transport, Golgi membrane-ER membrane @@ -83506,9 +83569,10 @@ - s_3195: 1 - lower_bound: -1000 - upper_bound: 1000 + - gene_reaction_rule: YAL026C - annotation: !!omap - sbo: SBO:0000655 - - confidence_score: 0 + - confidence_score: 2 - !!omap - id: r_3828 - name: phosphatidylethanolamine (1-18:1, 2-18:1) transport, Golgi membrane-ER membrane @@ -83517,9 +83581,10 @@ - s_3197: 1 - lower_bound: -1000 - upper_bound: 1000 + - gene_reaction_rule: YAL026C - annotation: !!omap - sbo: SBO:0000655 - - confidence_score: 0 + - confidence_score: 2 - !!omap - id: r_3829 - name: phosphatidate (1-16:0, 2-16:1) transport, ER membrane-vacuolar membrane @@ -84144,9 +84209,10 @@ - s_3465: 1 - lower_bound: -1000 - upper_bound: 1000 + - gene_reaction_rule: YAL026C - annotation: !!omap - sbo: SBO:0000655 - - confidence_score: 0 + - confidence_score: 2 - !!omap - id: r_3886 - name: phosphatidylethanolamine (1-16:1, 2-16:1) transport, ER membrane-cell envelope @@ -84155,9 +84221,10 @@ - s_3467: 1 - lower_bound: -1000 - upper_bound: 1000 + - gene_reaction_rule: YAL026C - annotation: !!omap - sbo: SBO:0000655 - - confidence_score: 0 + - confidence_score: 2 - !!omap - id: r_3887 - name: phosphatidylethanolamine (1-18:0, 2-16:1) transport, ER membrane-cell envelope @@ -84166,9 +84233,10 @@ - s_3469: 1 - lower_bound: -1000 - upper_bound: 1000 + - gene_reaction_rule: YAL026C - annotation: !!omap - sbo: SBO:0000655 - - confidence_score: 0 + - confidence_score: 2 - !!omap - id: r_3888 - name: phosphatidylethanolamine (1-18:1, 2-16:1) transport, ER membrane-cell envelope @@ -84177,9 +84245,10 @@ - s_3471: 1 - lower_bound: -1000 - upper_bound: 1000 + - gene_reaction_rule: YAL026C - annotation: !!omap - sbo: SBO:0000655 - - confidence_score: 0 + - confidence_score: 2 - !!omap - id: r_3889 - name: phosphatidylethanolamine (1-16:0, 2-18:1) transport, ER membrane-cell envelope @@ -84188,9 +84257,10 @@ - s_3473: 1 - lower_bound: -1000 - upper_bound: 1000 + - gene_reaction_rule: YAL026C - annotation: !!omap - sbo: SBO:0000655 - - confidence_score: 0 + - confidence_score: 2 - !!omap - id: r_3890 - name: phosphatidylethanolamine (1-16:1, 2-18:1) transport, ER membrane-cell envelope @@ -84199,9 +84269,10 @@ - s_3474: 1 - lower_bound: -1000 - upper_bound: 1000 + - gene_reaction_rule: YAL026C - annotation: !!omap - sbo: SBO:0000655 - - confidence_score: 0 + - confidence_score: 2 - !!omap - id: r_3891 - name: phosphatidylethanolamine (1-18:0, 2-18:1) transport, ER membrane-cell envelope @@ -84210,9 +84281,10 @@ - s_3475: 1 - lower_bound: -1000 - upper_bound: 1000 + - gene_reaction_rule: YAL026C - annotation: !!omap - sbo: SBO:0000655 - - confidence_score: 0 + - confidence_score: 2 - !!omap - id: r_3892 - name: phosphatidylethanolamine (1-18:1, 2-18:1) transport, ER membrane-cell envelope @@ -84221,9 +84293,10 @@ - s_3476: 1 - lower_bound: -1000 - upper_bound: 1000 + - gene_reaction_rule: YAL026C - annotation: !!omap - sbo: SBO:0000655 - - confidence_score: 0 + - confidence_score: 2 - !!omap - id: r_3893 - name: phosphatidyl-L-serine (1-16:0, 2-16:1) transport, ER membrane-cell envelope @@ -84232,9 +84305,10 @@ - s_3478: 1 - lower_bound: -1000 - upper_bound: 1000 + - gene_reaction_rule: YIL048W - annotation: !!omap - sbo: SBO:0000655 - - confidence_score: 0 + - confidence_score: 2 - !!omap - id: r_3894 - name: phosphatidyl-L-serine (1-16:1, 2-16:1) transport, ER membrane-cell envelope @@ -84243,9 +84317,10 @@ - s_3480: 1 - lower_bound: -1000 - upper_bound: 1000 + - gene_reaction_rule: YIL048W - annotation: !!omap - sbo: SBO:0000655 - - confidence_score: 0 + - confidence_score: 2 - !!omap - id: r_3895 - name: phosphatidyl-L-serine (1-18:0, 2-16:1) transport, ER membrane-cell envelope @@ -84254,9 +84329,10 @@ - s_3482: 1 - lower_bound: -1000 - upper_bound: 1000 + - gene_reaction_rule: YIL048W - annotation: !!omap - sbo: SBO:0000655 - - confidence_score: 0 + - confidence_score: 2 - !!omap - id: r_3896 - name: phosphatidyl-L-serine (1-18:1, 2-16:1) transport, ER membrane-cell envelope @@ -84265,9 +84341,10 @@ - s_3484: 1 - lower_bound: -1000 - upper_bound: 1000 + - gene_reaction_rule: YIL048W - annotation: !!omap - sbo: SBO:0000655 - - confidence_score: 0 + - confidence_score: 2 - !!omap - id: r_3897 - name: phosphatidyl-L-serine (1-16:0, 2-18:1) transport, ER membrane-cell envelope @@ -84276,9 +84353,10 @@ - s_3486: 1 - lower_bound: -1000 - upper_bound: 1000 + - gene_reaction_rule: YIL048W - annotation: !!omap - sbo: SBO:0000655 - - confidence_score: 0 + - confidence_score: 2 - !!omap - id: r_3898 - name: phosphatidyl-L-serine (1-16:1, 2-18:1) transport, ER membrane-cell envelope @@ -84287,9 +84365,10 @@ - s_3487: 1 - lower_bound: -1000 - upper_bound: 1000 + - gene_reaction_rule: YIL048W - annotation: !!omap - sbo: SBO:0000655 - - confidence_score: 0 + - confidence_score: 2 - !!omap - id: r_3899 - name: phosphatidyl-L-serine (1-18:0, 2-18:1) transport, ER membrane-cell envelope @@ -84298,9 +84377,10 @@ - s_3488: 1 - lower_bound: -1000 - upper_bound: 1000 + - gene_reaction_rule: YIL048W - annotation: !!omap - sbo: SBO:0000655 - - confidence_score: 0 + - confidence_score: 2 - !!omap - id: r_3900 - name: phosphatidyl-L-serine (1-18:1, 2-18:1) transport, ER membrane-cell envelope @@ -84309,9 +84389,10 @@ - s_3489: 1 - lower_bound: -1000 - upper_bound: 1000 + - gene_reaction_rule: YIL048W - annotation: !!omap - sbo: SBO:0000655 - - confidence_score: 0 + - confidence_score: 2 - !!omap - id: r_3901 - name: lignoceric acid transport, cell envelope-ER membrane @@ -84966,10 +85047,11 @@ - s_3219: 1 - lower_bound: -1000 - upper_bound: 1000 + - gene_reaction_rule: YBR192W - annotation: !!omap - metanetx.reaction: MNXR96806 - sbo: SBO:0000655 - - confidence_score: 0 + - confidence_score: 2 - !!omap - id: r_3960 - name: CTP transport, mitochondrion-mitochondrial membrane @@ -84978,10 +85060,11 @@ - s_3093: 1 - lower_bound: -1000 - upper_bound: 1000 + - gene_reaction_rule: YBR192W - annotation: !!omap - metanetx.reaction: MNXR96946 - sbo: SBO:0000655 - - confidence_score: 0 + - confidence_score: 2 - !!omap - id: r_3961 - name: phosphate transport, mitochondrion-mitochondrial membrane @@ -84990,10 +85073,11 @@ - s_3228: 1 - lower_bound: -1000 - upper_bound: 1000 + - gene_reaction_rule: YER053C or YJR077C or YLR348C - annotation: !!omap - metanetx.reaction: MNXR102871 - sbo: SBO:0000655 - - confidence_score: 0 + - confidence_score: 2 - !!omap - id: r_3962 - name: diphosphate transport, mitochondrion-mitochondrial membrane @@ -90962,10 +91046,11 @@ - s_4086: 1 - lower_bound: -1000 - upper_bound: 1000 + - gene_reaction_rule: YJR152W or YKR093W - annotation: !!omap - metanetx.reaction: MNXR137072 - sbo: SBO:0000655 - - confidence_score: 1 + - confidence_score: 2 - !!omap - id: r_4362 - name: dipeptidase @@ -91339,10 +91424,11 @@ - s_4120: 1 - lower_bound: -1000 - upper_bound: 1000 + - gene_reaction_rule: YJR152W or YKR093W - annotation: !!omap - metanetx.reaction: MNXR137135 - sbo: SBO:0000655 - - confidence_score: 1 + - confidence_score: 2 - !!omap - id: r_4388 - name: cyclic phosphodiesterase @@ -91448,10 +91534,11 @@ - s_4130: -1 - lower_bound: -1000 - upper_bound: 1000 + - gene_reaction_rule: YDL245C or YDR342C or YDR343C or YDR345C or YEL069C or YFL011W or YHR092C or YHR094C or YHR096C or YJL214W or YJL219W or YJR158W or YMR011W or YNR072W or YOL156W - annotation: !!omap - metanetx.reaction: MNXR104707 - sbo: SBO:0000655 - - confidence_score: 1 + - confidence_score: 2 - !!omap - id: r_4396 - name: Acetoacetate:CoA ligase (AMP-forming) @@ -91495,10 +91582,11 @@ - s_4035: 1 - lower_bound: -1000 - upper_bound: 1000 + - gene_reaction_rule: YJR152W or YKR093W - annotation: !!omap - metanetx.reaction: MNXR137087 - sbo: SBO:0000655 - - confidence_score: 1 + - confidence_score: 2 - !!omap - id: r_4399 - name: L-alanyl-L-glutamate transport in via proton symport @@ -91551,9 +91639,10 @@ - s_4041: 1 - lower_bound: -1000 - upper_bound: 1000 + - gene_reaction_rule: YJR152W or YKR093W - annotation: !!omap - sbo: SBO:0000655 - - confidence_score: 1 + - confidence_score: 2 - !!omap - id: r_4403 - name: Triphosphate phosphohydrolase @@ -91570,7 +91659,7 @@ - kegg.reaction: R00138 - metanetx.reaction: MNXR103069 - sbo: SBO:0000176 - - confidence_score: 1 + - confidence_score: 2 - !!omap - id: r_4404 - name: Gly-Asn transport via proton symport (extracellular to cytosol) @@ -91581,9 +91670,10 @@ - s_4054: 1 - lower_bound: -1000 - upper_bound: 1000 + - gene_reaction_rule: YJR152W or YKR093W - annotation: !!omap - sbo: SBO:0000655 - - confidence_score: 1 + - confidence_score: 2 - !!omap - id: r_4405 - name: glycerol 1-phosphate transport @@ -91635,10 +91725,11 @@ - s_4038: 1 - lower_bound: -1000 - upper_bound: 1000 + - gene_reaction_rule: YJR152W or YKR093W - annotation: !!omap - metanetx.reaction: MNXR101006 - sbo: SBO:0000655 - - confidence_score: 1 + - confidence_score: 2 - !!omap - id: r_4409 - name: L-alanyl-gamma-L-glutamate peptidase @@ -91872,10 +91963,11 @@ - s_4057: 1 - lower_bound: -1000 - upper_bound: 1000 + - gene_reaction_rule: YJR152W or YKR093W - annotation: !!omap - metanetx.reaction: MNXR137074 - sbo: SBO:0000655 - - confidence_score: 1 + - confidence_score: 2 - !!omap - id: r_4425 - name: Gly-Gln transport via proton symport @@ -91942,10 +92034,11 @@ - s_4051: 1 - lower_bound: -1000 - upper_bound: 1000 + - gene_reaction_rule: YJR152W or YKR093W - annotation: !!omap - metanetx.reaction: MNXR137107 - sbo: SBO:0000655 - - confidence_score: 1 + - confidence_score: 2 - !!omap - id: r_4430 - name: Ala-His transport via proton symport @@ -92030,7 +92123,7 @@ - kegg.reaction: R08658 - metanetx.reaction: MNXR112173 - sbo: SBO:0000176 - - confidence_score: 1 + - confidence_score: 2 - !!omap - id: r_4436 - name: nucleotide-specific phosphatase (thymidine 5'-monophosphate) @@ -92054,9 +92147,10 @@ - s_4060: 1 - lower_bound: -1000 - upper_bound: 1000 + - gene_reaction_rule: YJR152W or YKR093W - annotation: !!omap - sbo: SBO:0000655 - - confidence_score: 1 + - confidence_score: 2 - !!omap - id: r_4438 - name: Gly-Glu transport via proton symport (cytosol to vacuole) @@ -92116,7 +92210,6 @@ - upper_bound: 1000 - annotation: !!omap - sbo: SBO:0000627 - - confidence_score: 1 - !!omap - id: r_4443 - name: 23cGMP transport via diffusion (extracellular to periplasm) @@ -92191,9 +92284,10 @@ - s_4144: 1 - lower_bound: -1000 - upper_bound: 1000 + - gene_reaction_rule: YJR152W or YKR093W - annotation: !!omap - sbo: SBO:0000655 - - confidence_score: 1 + - confidence_score: 2 - !!omap - id: r_4449 - name: Met-Ala transport via proton symport (cytosol to vacuole) @@ -92307,10 +92401,11 @@ - s_4154: -1 - lower_bound: -1000 - upper_bound: 1000 + - gene_reaction_rule: YDR093W - annotation: !!omap - metanetx.reaction: MNXR135002 - sbo: SBO:0000655 - - confidence_score: 1 + - confidence_score: 2 - !!omap - id: r_4458 - name: 6-Phospho-D-gluconate transport in/out via proton symport @@ -92451,9 +92546,10 @@ - s_4165: -1 - lower_bound: -1000 - upper_bound: 1000 + - gene_reaction_rule: YDR342C or YHR092C - annotation: !!omap - sbo: SBO:0000655 - - confidence_score: 1 + - confidence_score: 2 - !!omap - id: r_4469 - name: L-Citrulline transport in via proton symport @@ -92464,10 +92560,11 @@ - s_4166: -1 - lower_bound: -1000 - upper_bound: 1000 + - gene_reaction_rule: YKR039W - annotation: !!omap - metanetx.reaction: MNXR96737 - sbo: SBO:0000655 - - confidence_score: 1 + - confidence_score: 2 - !!omap - id: r_4470 - name: Dihydroxyacetone transport via facilitated diffusion @@ -92490,9 +92587,10 @@ - s_4169: 1 - lower_bound: -1000 - upper_bound: 1000 + - gene_reaction_rule: YJR152W or YKR093W - annotation: !!omap - sbo: SBO:0000655 - - confidence_score: 1 + - confidence_score: 2 - !!omap - id: r_4472 - name: Ala-Leu transport via proton symport (cytosol to vacuole) @@ -92516,10 +92614,11 @@ - s_4171: 1 - lower_bound: -1000 - upper_bound: 1000 + - gene_reaction_rule: YJR152W or YKR093W - annotation: !!omap - metanetx.reaction: MNXR137133 - sbo: SBO:0000655 - - confidence_score: 1 + - confidence_score: 2 - !!omap - id: r_4474 - name: L-alanylglycine transport via proton antiport @@ -92668,7 +92767,7 @@ - kegg.reaction: R01288 - metanetx.reaction: MNXR104382 - sbo: SBO:0000176 - - confidence_score: 1 + - confidence_score: 2 - !!omap - id: r_4485 - name: 4-Hydroxyphenylpyruvate:oxygen oxidoreductase (hydroxylating,decarboxylating) @@ -92805,10 +92904,11 @@ - s_4133: -1 - lower_bound: -1000 - upper_bound: 1000 + - gene_reaction_rule: YNL065W - annotation: !!omap - metanetx.reaction: MNXR95208 - sbo: SBO:0000655 - - confidence_score: 1 + - confidence_score: 2 - !!omap - id: r_4494 - name: methanol exchange @@ -92819,7 +92919,6 @@ - annotation: !!omap - metanetx.reaction: MNXR98748 - sbo: SBO:0000627 - - confidence_score: 1 - !!omap - id: r_4495 - name: alkaline phosphatase @@ -93820,7 +93919,7 @@ - confidence_score: 0 - !!omap - id: r_4587 - - name: Ca(2+) transport + - name: Ca(2+) transport - metabolites: !!omap - s_0794: 1 - s_0796: -1 @@ -94034,6 +94133,9 @@ - !!omap - id: YAL023C - name: PMT2 + - !!omap + - id: YAL026C + - name: DRS2 - !!omap - id: YAL035W - name: FUN12 @@ -94640,6 +94742,9 @@ - !!omap - id: YDR074W - name: TPS2 + - !!omap + - id: YDR093W + - name: DNF2 - !!omap - id: YDR098C - name: GRX3 @@ -95648,6 +95753,9 @@ - !!omap - id: YIL043C - name: CBR1 + - !!omap + - id: YIL048W + - name: NEO1 - !!omap - id: YIL053W - name: GPP1 @@ -95783,6 +95891,9 @@ - !!omap - id: YJL130C - name: URA2 + - !!omap + - id: YJL133W + - name: MRS3 - !!omap - id: YJL134W - name: LCB3 @@ -96095,6 +96206,9 @@ - !!omap - id: YKR043C - name: SHB17 + - !!omap + - id: YKR052C + - name: MRS4 - !!omap - id: YKR053C - name: YSR3 @@ -96125,6 +96239,9 @@ - !!omap - id: YKR089C - name: TGL4 + - !!omap + - id: YKR093W + - name: PTR2 - !!omap - id: YKR097W - name: PCK1 @@ -96164,6 +96281,9 @@ - !!omap - id: YLL052C - name: AQY2 + - !!omap + - id: YLL053C + - name: YLL053C - !!omap - id: YLL057C - name: JLP1 @@ -96695,6 +96815,9 @@ - !!omap - id: YNL052W - name: COX5A + - !!omap + - id: YNL065W + - name: AQR1 - !!omap - id: YNL071W - name: LAT1 @@ -97112,6 +97235,9 @@ - !!omap - id: YOR303W - name: CPA1 + - !!omap + - id: YOR306C + - name: MCH5 - !!omap - id: YOR311C - name: DGK1 @@ -97331,6 +97457,9 @@ - !!omap - id: YPR006C - name: ICL2 + - !!omap + - id: YPR011C + - name: YPR011C - !!omap - id: YPR020W - name: ATP20 @@ -97352,6 +97481,9 @@ - !!omap - id: YPR047W - name: MSF1 + - !!omap + - id: YPR058W + - name: YMC1 - !!omap - id: YPR060C - name: ARO7 diff --git a/README.md b/README.md index 4356db24..9f4b579f 100644 --- a/README.md +++ b/README.md @@ -16,7 +16,7 @@ This repository contains the current consensus genome-scale metabolic model of _ |Taxonomy | Template Model | Reactions | Metabolites| Genes | |:-------:|:--------------:|:---------:|:----------:|:-----:| -|_Saccharomyces cerevisiae_|[Yeast 7.6](https://sourceforge.net/projects/yeast/)|3963|2691|1139| +|_Saccharomyces cerevisiae_|[Yeast 7.6](https://sourceforge.net/projects/yeast/)|3963|2691|1150| This repository is administered by Benjamín J. Sánchez ([@BenjaSanchez](https://github.com/benjasanchez)), Division of Systems and Synthetic Biology, Department of Biology and Biological Engineering, Chalmers University of Technology. @@ -59,7 +59,7 @@ Make sure to load/save the model with the corresponding wrapper functions! The model is available in `.xml`, `.txt`, `.yml`, `.mat` and `.xlsx` (the last 2 extensions only in `master`). Additionally, the following 2 files are available: * `dependencies.txt`: Tracks versions of toolboxes & SBML used for saving the model. -* `boundaryMets.txt`: Contains a list of all boundary metabolites in model, listing the id and name. +* `boundaryMets.txt`: Contains a list of all boundary metabolites in model, listing the id and name. ### Complementary Scripts @@ -88,7 +88,7 @@ The model is available in `.xml`, `.txt`, `.yml`, `.mat` and `.xlsx` (the last 2 ## Contributing Contributions are always welcome! Please read the [contributions guideline](https://github.com/SysBioChalmers/yeast-GEM/blob/master/.github/CONTRIBUTING.md) to get started. - + ## Contributors * [Mihail Anton](https://www.chalmers.se/en/staff/Pages/mihail-anton.aspx) ([@mihai-sysbio](https://github.com/mihai-sysbio)), Chalmers University of Technology, Sweden