diff --git a/data/deprecatedIdentifiers/deprecatedReactions.tsv b/data/deprecatedIdentifiers/deprecatedReactions.tsv
index 96e470b5..71108f9c 100644
--- a/data/deprecatedIdentifiers/deprecatedReactions.tsv
+++ b/data/deprecatedIdentifiers/deprecatedReactions.tsv
@@ -108,6 +108,37 @@ rxns	rxnKEGGID	rxnBiGGID	rxnEHMNID	rxnHepatoNET1ID	rxnREACTOMEID	rxnRecon3DID	rx
 "MAR00562"	""	"ETF"	""	""	""	"ETF"	"MNXR97965"	""	""	""	0	""	""	"ETF"
 "MAR00563"	""	"ETFQO"	""	""	""	"ETFQO"	"MNXR97966"	""	""	""	0	""	""	"ETFQO"
 "MAR05434"	""	"FAOXC3DC"	""	""	""	"FAOXC3DC"	""	""	""	""	0	""	""	"FAOXC3DC"
+"MAR02185"	""	""	""	""	""	"r0701"	""	""	""	""	0	""	""	"r0701"
+"MAR11649"	""	""	""	""	""	"PAIL_hs_t1e"	""	""	""	""	0	""	""	"PAIL_hs_t1e"
+"MAR11729"	""	""	""	""	""	"2HXIC_Lt2e"	""	""	""	""	0	""	""	"2HXIC_Lt2e"
+"MAR10469"	""	""	""	""	""	"3HCINNMsec"	""	""	""	""	0	""	""	"3HCINNMsec"
+"MAR10467"	""	""	""	""	""	"PCSup"	""	""	""	""	0	""	""	"PCSup"
+"MAR10471"	""	""	""	""	""	"3HPPAsec"	""	""	""	""	0	""	""	"3HPPAsec"
+"MAR01823"	""	"VITD3tm3"	""	""	""	"VITD3tm3"	"MNXR105203"	""	""	""	0	""	""	"VITD3tm3"
+"MAR11988"	""	""	""	""	""	"HC00005t1e"	""	""	""	""	0	""	""	"HC00005t1e"
+"MAR11991"	""	""	""	""	""	"HC00006t1e"	""	""	""	""	0	""	""	"HC00006t1e"
+"MAR11994"	""	""	""	""	""	"HC00007t1e"	""	""	""	""	0	""	""	"HC00007t1e"
+"MAR11997"	""	""	""	""	""	"HC00008t1e"	""	""	""	""	0	""	""	"HC00008t1e"
+"MAR12000"	""	""	""	""	""	"HC00009t1e"	""	""	""	""	0	""	""	"HC00009t1e"
+"MAR11652"	""	""	""	""	""	"PAILSTE_HSt1e"	""	""	""	""	0	""	""	"PAILSTE_HSt1e"
+"MAR11650"	""	""	""	""	""	"PAILR_HSt1e"	""	""	""	""	0	""	""	"PAILR_HSt1e"
+"MAR11725"	""	""	""	""	""	"SPHMYLN1824_hs_t1"	""	""	""	""	0	""	""	"SPHMYLN1824_hs_t1"
+"MAR11697"	""	""	""	""	""	"SPHMYLN180241_hs_t1"	""	""	""	""	0	""	""	"SPHMYLN180241_hs_t1"
+"MAR11727"	""	""	""	""	""	"SPHMYLN1825_hs_t1"	""	""	""	""	0	""	""	"SPHMYLN1825_hs_t1"
+"MAR11699"	""	""	""	""	""	"SPHMYLN18114_hs_t1"	""	""	""	""	0	""	""	"SPHMYLN18114_hs_t1"
+"MAR11701"	""	""	""	""	""	"SPHMYLN18115_hs_t1"	""	""	""	""	0	""	""	"SPHMYLN18115_hs_t1"
+"MAR11703"	""	""	""	""	""	"SPHMYLN18116_hs_t1"	""	""	""	""	0	""	""	"SPHMYLN18116_hs_t1"
+"MAR11705"	""	""	""	""	""	"SPHMYLN181161_hs_t1"	""	""	""	""	0	""	""	"SPHMYLN181161_hs_t1"
+"MAR11707"	""	""	""	""	""	"SPHMYLN18117_hs_t1"	""	""	""	""	0	""	""	"SPHMYLN18117_hs_t1"
+"MAR11709"	""	""	""	""	""	"SPHMYLN18118_hs_t1"	""	""	""	""	0	""	""	"SPHMYLN18118_hs_t1"
+"MAR11711"	""	""	""	""	""	"SPHMYLN181181_hs_t1"	""	""	""	""	0	""	""	"SPHMYLN181181_hs_t1"
+"MAR11713"	""	""	""	""	""	"SPHMYLN18120_hs_t1"	""	""	""	""	0	""	""	"SPHMYLN18120_hs_t1"
+"MAR11715"	""	""	""	""	""	"SPHMYLN181201_hs_t1"	""	""	""	""	0	""	""	"SPHMYLN181201_hs_t1"
+"MAR11717"	""	""	""	""	""	"SPHMYLN18121_hs_t1"	""	""	""	""	0	""	""	"SPHMYLN18121_hs_t1"
+"MAR11719"	""	""	""	""	""	"SPHMYLN18122_hs_t1"	""	""	""	""	0	""	""	"SPHMYLN18122_hs_t1"
+"MAR11721"	""	""	""	""	""	"SPHMYLN181221_hs_t1"	""	""	""	""	0	""	""	"SPHMYLN181221_hs_t1"
+"MAR11723"	""	""	""	""	""	"SPHMYLN18123_hs_t1"	""	""	""	""	0	""	""	"SPHMYLN18123_hs_t1"
+"MAR11651"	""	""	""	""	""	"PAILPALM_HSt1e"	""	""	""	""	0	""	""	"PAILPALM_HSt1e"
 "MAR20015"	"R02549"	"ABUTD;ABUTDm;R_ABUTD;R_ABUTDm"	""	""	""	""	"MNXR95191"	""	""	""	0	"RHEA:19105"	""	""
 "MAR20014"	"R03283"	"R_TMABADH;TMABADH"	""	""	""	""	"MNXR104876"	""	""	""	0	"RHEA:17985"	""	""
 "MAR20052"	""	"ALDD21;RE3076X;R_ALDD21;R_RE3076X"	""	""	""	""	"MNXR95747"	""	""	""	0	"RHEA:44016"	""	""
diff --git a/model/Human-GEM.yml b/model/Human-GEM.yml
index b2c7fa08..88682ac7 100644
--- a/model/Human-GEM.yml
+++ b/model/Human-GEM.yml
@@ -98333,7 +98333,7 @@
           - MAM02130c: 1
           - MAM02554c: 1
           - MAM02555c: -1
-      - lower_bound: 0
+      - lower_bound: -1000
       - upper_bound: 1000
       - gene_reaction_rule: "ENSG00000169710"
       - rxnNotes: ""
@@ -228080,23 +228080,7 @@
       - metabolites: !!omap
           - MAM03142c: 1
           - MAM03142m: -1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: ""
-      - rxnNotes: ""
-      - rxnFrom: "Recon3D"
-      - eccodes: ""
-      - references: ""
-      - subsystem:
-          - "Transport reactions"
-      - confidence_score: 0
-    - !!omap
-      - id: "MAR01823"
-      - name: "Vitamin D3 Transport in Mitochondria"
-      - metabolites: !!omap
-          - MAM03142c: -1
-          - MAM03142m: 1
-      - lower_bound: 0
+      - lower_bound: -1000
       - upper_bound: 1000
       - gene_reaction_rule: ""
       - rxnNotes: ""
@@ -229066,25 +229050,6 @@
       - subsystem:
           - "Bile acid biosynthesis"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR02185"
-      - name: " (3R)-3-Hydroxytetradecanoyl-[Acyl-Carrier-Protein]:NADP+ Oxidoreductase Fatty Acid Biosynthesis"
-      - metabolites: !!omap
-          - MAM00905c: 1
-          - MAM02039c: 1
-          - MAM02130c: -1
-          - MAM02554c: -1
-          - MAM02555c: 1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000169710"
-      - rxnNotes: ""
-      - rxnFrom: "Recon3D"
-      - eccodes: "2.3.1.85"
-      - references: "PMID:11750882;PMID:4452359;PMID:6137188;PMID:7567999;PMID:7834997;PMID:8962082"
-      - subsystem:
-          - "Fatty acid biosynthesis"
-      - confidence_score: 0
     - !!omap
       - id: "MAR02186"
       - name: "2-Amino-4-Hydroxy-6- (Erythro-1, 2, 3-Trihydroxypropyl) Dihydropteridine Triphosphate Phosphohydrolase (Alkaline Optimum)"
@@ -257748,23 +257713,7 @@
       - metabolites: !!omap
           - MAM03837c: -1
           - MAM03837e: 1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: ""
-      - rxnNotes: ""
-      - rxnFrom: "Recon3D"
-      - eccodes: ""
-      - references: "PMID:21343587"
-      - subsystem:
-          - "Transport reactions"
-      - confidence_score: 0
-    - !!omap
-      - id: "MAR10467"
-      - name: "Uptake of P-Cresol Sulfate"
-      - metabolites: !!omap
-          - MAM03837c: 1
-          - MAM03837e: -1
-      - lower_bound: 0
+      - lower_bound: -1000
       - upper_bound: 1000
       - gene_reaction_rule: ""
       - rxnNotes: ""
@@ -257780,29 +257729,13 @@
       - metabolites: !!omap
           - MAM03215c: 1
           - MAM03215e: -1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: ""
-      - rxnNotes: ""
-      - rxnFrom: "Recon3D"
-      - eccodes: ""
-      - references: "PMID:12904817"
-      - subsystem:
-          - "Transport reactions"
-      - confidence_score: 0
-    - !!omap
-      - id: "MAR10469"
-      - name: "3-Hydroxycinanmic Acid Secretion"
-      - metabolites: !!omap
-          - MAM03215c: -1
-          - MAM03215e: 1
-      - lower_bound: 0
+      - lower_bound: -1000
       - upper_bound: 1000
       - gene_reaction_rule: ""
       - rxnNotes: ""
       - rxnFrom: "Recon3D"
       - eccodes: ""
-      - references: "PMID:12904817"
+      - references: "PMID:12904817;PMID:12663291"
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
@@ -257812,23 +257745,7 @@
       - metabolites: !!omap
           - MAM03231c: 1
           - MAM03231e: -1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: ""
-      - rxnNotes: ""
-      - rxnFrom: "Recon3D"
-      - eccodes: ""
-      - references: "PMID:12904817;PMID:12663291"
-      - subsystem:
-          - "Transport reactions"
-      - confidence_score: 0
-    - !!omap
-      - id: "MAR10471"
-      - name: "3-Hydroxyphenylpropionic Acid Secretion"
-      - metabolites: !!omap
-          - MAM03231c: -1
-          - MAM03231e: 1
-      - lower_bound: 0
+      - lower_bound: -1000
       - upper_bound: 1000
       - gene_reaction_rule: ""
       - rxnNotes: ""
@@ -276666,13 +276583,13 @@
       - metabolites: !!omap
           - MAM02750c: -1
           - MAM02750e: 1
-      - lower_bound: 0
+      - lower_bound: -1000
       - upper_bound: 1000
       - gene_reaction_rule: ""
       - rxnNotes: ""
       - rxnFrom: "Recon3D"
-      - eccodes: ""
-      - references: "PMID:8145081"
+      - eccodes: "3.6.3.44;3.6.3.1"
+      - references: "PMID:8145081;PMID:10856719"
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
@@ -276682,13 +276599,13 @@
       - metabolites: !!omap
           - MAM03803c: -1
           - MAM03803e: 1
-      - lower_bound: 0
+      - lower_bound: -1000
       - upper_bound: 1000
       - gene_reaction_rule: ""
       - rxnNotes: ""
       - rxnFrom: "Recon3D"
       - eccodes: ""
-      - references: "PMID:8145081"
+      - references: "PMID:8145081;PMID:10856719"
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
@@ -276698,13 +276615,13 @@
       - metabolites: !!omap
           - MAM03802c: -1
           - MAM03802e: 1
-      - lower_bound: 0
+      - lower_bound: -1000
       - upper_bound: 1000
       - gene_reaction_rule: ""
       - rxnNotes: ""
       - rxnFrom: "Recon3D"
       - eccodes: ""
-      - references: "PMID:8145081"
+      - references: "PMID:8145081;PMID:10856719"
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
@@ -276714,13 +276631,13 @@
       - metabolites: !!omap
           - MAM03804c: -1
           - MAM03804e: 1
-      - lower_bound: 0
+      - lower_bound: -1000
       - upper_bound: 1000
       - gene_reaction_rule: ""
       - rxnNotes: ""
       - rxnFrom: "Recon3D"
       - eccodes: ""
-      - references: "PMID:8145081"
+      - references: "PMID:8145081;PMID:10856719"
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
@@ -277628,13 +277545,13 @@
       - metabolites: !!omap
           - MAM03936c: -1
           - MAM03936e: 1
-      - lower_bound: 0
+      - lower_bound: -1000
       - upper_bound: 1000
       - gene_reaction_rule: ""
       - rxnNotes: ""
       - rxnFrom: "Recon3D"
-      - eccodes: ""
-      - references: ""
+      - eccodes: "3.6.3.1"
+      - references: "PMID:11581500;PMID:10856719"
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
@@ -277644,13 +277561,13 @@
       - metabolites: !!omap
           - MAM03937c: -1
           - MAM03937e: 1
-      - lower_bound: 0
+      - lower_bound: -1000
       - upper_bound: 1000
       - gene_reaction_rule: ""
       - rxnNotes: ""
       - rxnFrom: "Recon3D"
-      - eccodes: ""
-      - references: ""
+      - eccodes: "3.6.3.1"
+      - references: "PMID:11581500;PMID:10856719"
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
@@ -277660,13 +277577,13 @@
       - metabolites: !!omap
           - MAM03938c: -1
           - MAM03938e: 1
-      - lower_bound: 0
+      - lower_bound: -1000
       - upper_bound: 1000
       - gene_reaction_rule: ""
       - rxnNotes: ""
       - rxnFrom: "Recon3D"
-      - eccodes: ""
-      - references: ""
+      - eccodes: "3.6.3.1"
+      - references: "PMID:11581500;PMID:10856719"
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
@@ -277676,13 +277593,13 @@
       - metabolites: !!omap
           - MAM03940c: -1
           - MAM03940e: 1
-      - lower_bound: 0
+      - lower_bound: -1000
       - upper_bound: 1000
       - gene_reaction_rule: ""
       - rxnNotes: ""
       - rxnFrom: "Recon3D"
-      - eccodes: ""
-      - references: ""
+      - eccodes: "3.6.3.1"
+      - references: "PMID:11581500;PMID:10856719"
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
@@ -277692,13 +277609,13 @@
       - metabolites: !!omap
           - MAM03939c: -1
           - MAM03939e: 1
-      - lower_bound: 0
+      - lower_bound: -1000
       - upper_bound: 1000
       - gene_reaction_rule: ""
       - rxnNotes: ""
       - rxnFrom: "Recon3D"
-      - eccodes: ""
-      - references: ""
+      - eccodes: "3.6.3.1"
+      - references: "PMID:11581500;PMID:10856719"
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
@@ -277708,13 +277625,13 @@
       - metabolites: !!omap
           - MAM03941c: -1
           - MAM03941e: 1
-      - lower_bound: 0
+      - lower_bound: -1000
       - upper_bound: 1000
       - gene_reaction_rule: ""
       - rxnNotes: ""
       - rxnFrom: "Recon3D"
-      - eccodes: "2.3.1.13"
-      - references: ""
+      - eccodes: "2.3.1.13;3.6.3.1"
+      - references: "PMID:11581500;PMID:10856719"
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
@@ -277724,13 +277641,13 @@
       - metabolites: !!omap
           - MAM03943c: -1
           - MAM03943e: 1
-      - lower_bound: 0
+      - lower_bound: -1000
       - upper_bound: 1000
       - gene_reaction_rule: ""
       - rxnNotes: ""
       - rxnFrom: "Recon3D"
       - eccodes: ""
-      - references: ""
+      - references: "PMID:11581500;PMID:10856719"
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
@@ -277740,13 +277657,13 @@
       - metabolites: !!omap
           - MAM03942c: -1
           - MAM03942e: 1
-      - lower_bound: 0
+      - lower_bound: -1000
       - upper_bound: 1000
       - gene_reaction_rule: ""
       - rxnNotes: ""
       - rxnFrom: "Recon3D"
       - eccodes: ""
-      - references: ""
+      - references: "PMID:11581500;PMID:10856719"
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
@@ -277756,13 +277673,13 @@
       - metabolites: !!omap
           - MAM03945c: -1
           - MAM03945e: 1
-      - lower_bound: 0
+      - lower_bound: -1000
       - upper_bound: 1000
       - gene_reaction_rule: ""
       - rxnNotes: ""
       - rxnFrom: "Recon3D"
       - eccodes: ""
-      - references: ""
+      - references: "PMID:11581500;PMID:10856719"
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
@@ -277772,13 +277689,13 @@
       - metabolites: !!omap
           - MAM03944c: -1
           - MAM03944e: 1
-      - lower_bound: 0
+      - lower_bound: -1000
       - upper_bound: 1000
       - gene_reaction_rule: ""
       - rxnNotes: ""
       - rxnFrom: "Recon3D"
       - eccodes: ""
-      - references: ""
+      - references: "PMID:11581500;PMID:10856719"
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
@@ -277788,13 +277705,13 @@
       - metabolites: !!omap
           - MAM03946c: -1
           - MAM03946e: 1
-      - lower_bound: 0
+      - lower_bound: -1000
       - upper_bound: 1000
       - gene_reaction_rule: ""
       - rxnNotes: ""
       - rxnFrom: "Recon3D"
       - eccodes: ""
-      - references: ""
+      - references: "PMID:11581500;PMID:10856719"
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
@@ -277804,13 +277721,13 @@
       - metabolites: !!omap
           - MAM03948c: -1
           - MAM03948e: 1
-      - lower_bound: 0
+      - lower_bound: -1000
       - upper_bound: 1000
       - gene_reaction_rule: ""
       - rxnNotes: ""
       - rxnFrom: "Recon3D"
       - eccodes: ""
-      - references: ""
+      - references: "PMID:11581500;PMID:10856719"
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
@@ -277820,13 +277737,13 @@
       - metabolites: !!omap
           - MAM03947c: -1
           - MAM03947e: 1
-      - lower_bound: 0
+      - lower_bound: -1000
       - upper_bound: 1000
       - gene_reaction_rule: ""
       - rxnNotes: ""
       - rxnFrom: "Recon3D"
       - eccodes: "2.3.1.13"
-      - references: ""
+      - references: "PMID:11581500;PMID:10856719"
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
@@ -277836,13 +277753,13 @@
       - metabolites: !!omap
           - MAM03949c: -1
           - MAM03949e: 1
-      - lower_bound: 0
+      - lower_bound: -1000
       - upper_bound: 1000
       - gene_reaction_rule: ""
       - rxnNotes: ""
       - rxnFrom: "Recon3D"
       - eccodes: ""
-      - references: ""
+      - references: "PMID:11581500;PMID:10856719"
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
@@ -277852,13 +277769,13 @@
       - metabolites: !!omap
           - MAM03950c: -1
           - MAM03950e: 1
-      - lower_bound: 0
+      - lower_bound: -1000
       - upper_bound: 1000
       - gene_reaction_rule: ""
       - rxnNotes: ""
       - rxnFrom: "Recon3D"
       - eccodes: ""
-      - references: ""
+      - references: "PMID:11581500;PMID:10856719"
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
@@ -277868,13 +277785,13 @@
       - metabolites: !!omap
           - MAM03951c: -1
           - MAM03951e: 1
-      - lower_bound: 0
+      - lower_bound: -1000
       - upper_bound: 1000
       - gene_reaction_rule: ""
       - rxnNotes: ""
       - rxnFrom: "Recon3D"
       - eccodes: ""
-      - references: ""
+      - references: "PMID:11581500;PMID:10856719"
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
@@ -277935,70 +277852,6 @@
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR11649"
-      - name: "Transport of 1-Phosphatidyl-1D-Myo-Inositol, Vescicular"
-      - metabolites: !!omap
-          - MAM02750c: 1
-          - MAM02750e: -1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: ""
-      - rxnNotes: ""
-      - rxnFrom: "Recon3D"
-      - eccodes: "3.6.3.44;3.6.3.1"
-      - references: "PMID:10856719"
-      - subsystem:
-          - "Transport reactions"
-      - confidence_score: 0
-    - !!omap
-      - id: "MAR11650"
-      - name: "Transport of 1-Arachidonoylglycerophosphoinositol, Vescicular"
-      - metabolites: !!omap
-          - MAM03802c: 1
-          - MAM03802e: -1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: ""
-      - rxnNotes: ""
-      - rxnFrom: "Recon3D"
-      - eccodes: ""
-      - references: "PMID:10856719"
-      - subsystem:
-          - "Transport reactions"
-      - confidence_score: 0
-    - !!omap
-      - id: "MAR11651"
-      - name: "Transport of 1-Palmitoylglycerophosphoinositol, Vescicular"
-      - metabolites: !!omap
-          - MAM03803c: 1
-          - MAM03803e: -1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: ""
-      - rxnNotes: ""
-      - rxnFrom: "Recon3D"
-      - eccodes: ""
-      - references: "PMID:10856719"
-      - subsystem:
-          - "Transport reactions"
-      - confidence_score: 0
-    - !!omap
-      - id: "MAR11652"
-      - name: "Transport of 1-Stearoylglycerophosphoinositol, Vescicular"
-      - metabolites: !!omap
-          - MAM03804c: 1
-          - MAM03804e: -1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: ""
-      - rxnNotes: ""
-      - rxnFrom: "Recon3D"
-      - eccodes: ""
-      - references: "PMID:10856719"
-      - subsystem:
-          - "Transport reactions"
-      - confidence_score: 0
     - !!omap
       - id: "MAR11653"
       - name: "Transport of 2-Linoleoylglycerophosphocholine, Vescicular"
@@ -278713,22 +278566,6 @@
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR11697"
-      - name: "Transport of Sphingomyelin (D18:0/24:1) Vescicular Transport"
-      - metabolites: !!omap
-          - MAM03936c: 1
-          - MAM03936e: -1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: ""
-      - rxnNotes: ""
-      - rxnFrom: "Recon3D"
-      - eccodes: "3.6.3.1"
-      - references: "PMID:11581500;PMID:10856719"
-      - subsystem:
-          - "Transport reactions"
-      - confidence_score: 0
     - !!omap
       - id: "MAR11698"
       - name: "Transport of Sphingomyelin (D18:1/14:0), Active Transport"
@@ -278750,22 +278587,6 @@
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR11699"
-      - name: "Transport of Sphingomyelin (D18:1/14:0), Vescicular Transport"
-      - metabolites: !!omap
-          - MAM03937c: 1
-          - MAM03937e: -1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: ""
-      - rxnNotes: ""
-      - rxnFrom: "Recon3D"
-      - eccodes: "3.6.3.1"
-      - references: "PMID:11581500;PMID:10856719"
-      - subsystem:
-          - "Transport reactions"
-      - confidence_score: 0
     - !!omap
       - id: "MAR11700"
       - name: "Transport of Sphingomyelin (D18:1/15:0), Active Transport"
@@ -278787,22 +278608,6 @@
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR11701"
-      - name: "Transport of Sphingomyelin (D18:1/15:0), Vescicular Transport"
-      - metabolites: !!omap
-          - MAM03938c: 1
-          - MAM03938e: -1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: ""
-      - rxnNotes: ""
-      - rxnFrom: "Recon3D"
-      - eccodes: "3.6.3.1"
-      - references: "PMID:11581500;PMID:10856719"
-      - subsystem:
-          - "Transport reactions"
-      - confidence_score: 0
     - !!omap
       - id: "MAR11702"
       - name: "Transport of Sphingomyelin (D18:1/16:0), Active Transport"
@@ -278824,22 +278629,6 @@
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR11703"
-      - name: "Transport of Sphingomyelin (D18:1/16:0), Vescicular Transport"
-      - metabolites: !!omap
-          - MAM03940c: 1
-          - MAM03940e: -1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: ""
-      - rxnNotes: ""
-      - rxnFrom: "Recon3D"
-      - eccodes: "3.6.3.1"
-      - references: "PMID:11581500;PMID:10856719"
-      - subsystem:
-          - "Transport reactions"
-      - confidence_score: 0
     - !!omap
       - id: "MAR11704"
       - name: "Transport of Sphingomyelin (D18:1/16:1), Active Transport"
@@ -278861,22 +278650,6 @@
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR11705"
-      - name: "Transport of Sphingomyelin (D18:1/16:1), Vescicular Transport"
-      - metabolites: !!omap
-          - MAM03939c: 1
-          - MAM03939e: -1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: ""
-      - rxnNotes: ""
-      - rxnFrom: "Recon3D"
-      - eccodes: "3.6.3.1"
-      - references: "PMID:11581500;PMID:10856719"
-      - subsystem:
-          - "Transport reactions"
-      - confidence_score: 0
     - !!omap
       - id: "MAR11706"
       - name: "Transport of Sphingomyelin (D18:1/17:0), Active"
@@ -278898,22 +278671,6 @@
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR11707"
-      - name: "Transport of Sphingomyelin (D18:1/17:0), Vescicular"
-      - metabolites: !!omap
-          - MAM03941c: 1
-          - MAM03941e: -1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: ""
-      - rxnNotes: ""
-      - rxnFrom: "Recon3D"
-      - eccodes: "3.6.3.1"
-      - references: "PMID:11581500;PMID:10856719"
-      - subsystem:
-          - "Transport reactions"
-      - confidence_score: 0
     - !!omap
       - id: "MAR11708"
       - name: "Transport of Sphingomyelin (D18:1/18:0), Active"
@@ -278935,22 +278692,6 @@
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR11709"
-      - name: "Transport of Sphingomyelin (D18:1/18:0), Vescicular"
-      - metabolites: !!omap
-          - MAM03943c: 1
-          - MAM03943e: -1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: ""
-      - rxnNotes: ""
-      - rxnFrom: "Recon3D"
-      - eccodes: ""
-      - references: "PMID:11581500;PMID:10856719"
-      - subsystem:
-          - "Transport reactions"
-      - confidence_score: 0
     - !!omap
       - id: "MAR11710"
       - name: "Transport of Sphingomyelin (D18:1/18:1), Active"
@@ -278972,22 +278713,6 @@
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR11711"
-      - name: "Transport of Sphingomyelin (D18:1/18:1), Vescicular"
-      - metabolites: !!omap
-          - MAM03942c: 1
-          - MAM03942e: -1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: ""
-      - rxnNotes: ""
-      - rxnFrom: "Recon3D"
-      - eccodes: ""
-      - references: "PMID:11581500;PMID:10856719"
-      - subsystem:
-          - "Transport reactions"
-      - confidence_score: 0
     - !!omap
       - id: "MAR11712"
       - name: "Transport of Sphingomyelin (D18:1/20:0), Active"
@@ -279009,22 +278734,6 @@
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR11713"
-      - name: "Transport of Sphingomyelin (D18:1/20:0), Vescicular"
-      - metabolites: !!omap
-          - MAM03945c: 1
-          - MAM03945e: -1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: ""
-      - rxnNotes: ""
-      - rxnFrom: "Recon3D"
-      - eccodes: ""
-      - references: "PMID:11581500;PMID:10856719"
-      - subsystem:
-          - "Transport reactions"
-      - confidence_score: 0
     - !!omap
       - id: "MAR11714"
       - name: "Transport of Sphingomyelin (D18:1/20:1), Active"
@@ -279046,22 +278755,6 @@
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR11715"
-      - name: "Transport of Sphingomyelin (D18:1/20:1), Vescicular"
-      - metabolites: !!omap
-          - MAM03944c: 1
-          - MAM03944e: -1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: ""
-      - rxnNotes: ""
-      - rxnFrom: "Recon3D"
-      - eccodes: ""
-      - references: "PMID:11581500;PMID:10856719"
-      - subsystem:
-          - "Transport reactions"
-      - confidence_score: 0
     - !!omap
       - id: "MAR11716"
       - name: "Transport of Sphingomyelin (D18:1/21:0), Active"
@@ -279083,22 +278776,6 @@
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR11717"
-      - name: "Transport of Sphingomyelin (D18:1/21:0), Vescicular"
-      - metabolites: !!omap
-          - MAM03946c: 1
-          - MAM03946e: -1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: ""
-      - rxnNotes: ""
-      - rxnFrom: "Recon3D"
-      - eccodes: ""
-      - references: "PMID:11581500;PMID:10856719"
-      - subsystem:
-          - "Transport reactions"
-      - confidence_score: 0
     - !!omap
       - id: "MAR11718"
       - name: "Transport of Sphingomyelin (D18:1/22:0), Active Transport"
@@ -279120,22 +278797,6 @@
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR11719"
-      - name: "Transport of Sphingomyelin (D18:1/22:0), Vescicular Transport"
-      - metabolites: !!omap
-          - MAM03948c: 1
-          - MAM03948e: -1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: ""
-      - rxnNotes: ""
-      - rxnFrom: "Recon3D"
-      - eccodes: ""
-      - references: "PMID:11581500;PMID:10856719"
-      - subsystem:
-          - "Transport reactions"
-      - confidence_score: 0
     - !!omap
       - id: "MAR11720"
       - name: "Transport of Sphingomyelin (D18:1/22:1), Active"
@@ -279157,22 +278818,6 @@
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR11721"
-      - name: "Transport of Sphingomyelin (D18:1/22:1), Vescicular"
-      - metabolites: !!omap
-          - MAM03947c: 1
-          - MAM03947e: -1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: ""
-      - rxnNotes: ""
-      - rxnFrom: "Recon3D"
-      - eccodes: ""
-      - references: "PMID:11581500;PMID:10856719"
-      - subsystem:
-          - "Transport reactions"
-      - confidence_score: 0
     - !!omap
       - id: "MAR11722"
       - name: "Transport of Sphingomyelin (D18:1/23:0), Active"
@@ -279194,22 +278839,6 @@
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR11723"
-      - name: "Transport of Sphingomyelin (D18:1/23:0), Vescicular"
-      - metabolites: !!omap
-          - MAM03949c: 1
-          - MAM03949e: -1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: ""
-      - rxnNotes: ""
-      - rxnFrom: "Recon3D"
-      - eccodes: ""
-      - references: "PMID:11581500;PMID:10856719"
-      - subsystem:
-          - "Transport reactions"
-      - confidence_score: 0
     - !!omap
       - id: "MAR11724"
       - name: "Transport of Sphingomyelin (D18:0/24:0), Active Transport"
@@ -279231,22 +278860,6 @@
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR11725"
-      - name: "Transport of Sphingomyelin (D18:0/24:0), Vescicular Transport"
-      - metabolites: !!omap
-          - MAM03950c: 1
-          - MAM03950e: -1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: ""
-      - rxnNotes: ""
-      - rxnFrom: "Recon3D"
-      - eccodes: ""
-      - references: "PMID:11581500;PMID:10856719"
-      - subsystem:
-          - "Transport reactions"
-      - confidence_score: 0
     - !!omap
       - id: "MAR11726"
       - name: "Transport of Sphingomyelin (D18:0/25:0), Active Transport"
@@ -279268,29 +278881,13 @@
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR11727"
-      - name: "Transport of Sphingomyelin (D18:0/25:0), Vescicular Transport"
-      - metabolites: !!omap
-          - MAM03951c: 1
-          - MAM03951e: -1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: ""
-      - rxnNotes: ""
-      - rxnFrom: "Recon3D"
-      - eccodes: ""
-      - references: "PMID:11581500;PMID:10856719"
-      - subsystem:
-          - "Transport reactions"
-      - confidence_score: 0
     - !!omap
       - id: "MAR11728"
       - name: "Transport of 2-Hydroxy-Isocaproate, Extracellular, Uptake"
       - metabolites: !!omap
           - MAM03187c: 1
           - MAM03187e: -1
-      - lower_bound: 0
+      - lower_bound: -1000
       - upper_bound: 1000
       - gene_reaction_rule: ""
       - rxnNotes: ""
@@ -279300,22 +278897,6 @@
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR11729"
-      - name: "Transport of 2-Hydroxy-Isocaproate, Extracellular, Secretion"
-      - metabolites: !!omap
-          - MAM03187c: -1
-          - MAM03187e: 1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: ""
-      - rxnNotes: ""
-      - rxnFrom: "Recon3D"
-      - eccodes: ""
-      - references: ""
-      - subsystem:
-          - "Transport reactions"
-      - confidence_score: 0
     - !!omap
       - id: "MAR11730"
       - name: "Exchange of 2-Hydroxy-Isocaproate"
@@ -283641,7 +283222,7 @@
       - metabolites: !!omap
           - MAM01351c: -1
           - MAM01351e: 1
-      - lower_bound: 0
+      - lower_bound: -1000
       - upper_bound: 1000
       - gene_reaction_rule: ""
       - rxnNotes: ""
@@ -283666,29 +283247,13 @@
       - subsystem:
           - "Exchange/demand reactions"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR11988"
-      - name: "Transport of Apo B, Extracellular"
-      - metabolites: !!omap
-          - MAM01351c: 1
-          - MAM01351e: -1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: ""
-      - rxnNotes: ""
-      - rxnFrom: "Recon3D"
-      - eccodes: ""
-      - references: ""
-      - subsystem:
-          - "Transport reactions"
-      - confidence_score: 0
     - !!omap
       - id: "MAR11989"
       - name: "Transport of Apo C1, Extracellular"
       - metabolites: !!omap
           - MAM01353c: -1
           - MAM01353e: 1
-      - lower_bound: 0
+      - lower_bound: -1000
       - upper_bound: 1000
       - gene_reaction_rule: ""
       - rxnNotes: ""
@@ -283713,29 +283278,13 @@
       - subsystem:
           - "Exchange/demand reactions"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR11991"
-      - name: "Transport of Apo C1, Extracellular"
-      - metabolites: !!omap
-          - MAM01353c: 1
-          - MAM01353e: -1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: ""
-      - rxnNotes: ""
-      - rxnFrom: "Recon3D"
-      - eccodes: ""
-      - references: ""
-      - subsystem:
-          - "Transport reactions"
-      - confidence_score: 0
     - !!omap
       - id: "MAR11992"
       - name: "Transport of Apo C2, Extracellular"
       - metabolites: !!omap
           - MAM01354c: -1
           - MAM01354e: 1
-      - lower_bound: 0
+      - lower_bound: -1000
       - upper_bound: 1000
       - gene_reaction_rule: ""
       - rxnNotes: ""
@@ -283760,29 +283309,13 @@
       - subsystem:
           - "Exchange/demand reactions"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR11994"
-      - name: "Transport of Apo C2, Extracellular"
-      - metabolites: !!omap
-          - MAM01354c: 1
-          - MAM01354e: -1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: ""
-      - rxnNotes: ""
-      - rxnFrom: "Recon3D"
-      - eccodes: ""
-      - references: ""
-      - subsystem:
-          - "Transport reactions"
-      - confidence_score: 0
     - !!omap
       - id: "MAR11995"
       - name: "Transport of Apo C3, Extracellular"
       - metabolites: !!omap
           - MAM01355c: -1
           - MAM01355e: 1
-      - lower_bound: 0
+      - lower_bound: -1000
       - upper_bound: 1000
       - gene_reaction_rule: ""
       - rxnNotes: ""
@@ -283807,29 +283340,13 @@
       - subsystem:
           - "Exchange/demand reactions"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR11997"
-      - name: "Transport of Apo C3, Extracellular"
-      - metabolites: !!omap
-          - MAM01355c: 1
-          - MAM01355e: -1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: ""
-      - rxnNotes: ""
-      - rxnFrom: "Recon3D"
-      - eccodes: ""
-      - references: ""
-      - subsystem:
-          - "Transport reactions"
-      - confidence_score: 0
     - !!omap
       - id: "MAR11998"
       - name: "Transport of Apo E, Extracellular"
       - metabolites: !!omap
           - MAM01359c: -1
           - MAM01359e: 1
-      - lower_bound: 0
+      - lower_bound: -1000
       - upper_bound: 1000
       - gene_reaction_rule: ""
       - rxnNotes: ""
@@ -283854,22 +283371,6 @@
       - subsystem:
           - "Exchange/demand reactions"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR12000"
-      - name: "Transport of Apo E, Extracellular"
-      - metabolites: !!omap
-          - MAM01359c: 1
-          - MAM01359e: -1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: ""
-      - rxnNotes: ""
-      - rxnFrom: "Recon3D"
-      - eccodes: ""
-      - references: ""
-      - subsystem:
-          - "Transport reactions"
-      - confidence_score: 0
     - !!omap
       - id: "MAR12001"
       - name: "Dopamine 4-O-Sulfotransferase"
diff --git a/model/reactions.tsv b/model/reactions.tsv
index dc2c1b61..af0d5802 100644
--- a/model/reactions.tsv
+++ b/model/reactions.tsv
@@ -8582,7 +8582,6 @@ rxns	rxnKEGGID	rxnBiGGID	rxnEHMNID	rxnHepatoNET1ID	rxnREACTOMEID	rxnRecon3DID	rx
 "MAR01820"	""	"UGT1A10r"	""	""	""	"UGT1A10r"	"MNXR96258"	""	""	""	0	""	""	"UGT1A10r"
 "MAR01821"	""	"VALt5m"	""	""	""	"VALt5m"	"MNXR105190"	""	""	""	0	""	""	"VALt5m"
 "MAR01822"	""	"VITD3tm"	""	""	""	"VITD3tm"	"MNXR105203"	""	""	""	0	""	""	"VITD3tm"
-"MAR01823"	""	"VITD3tm3"	""	""	""	"VITD3tm3"	"MNXR105203"	""	""	""	0	""	""	"VITD3tm3"
 "MAR01824"	""	"XOL27OHtm"	""	""	""	"XOL27OHtm"	"MNXR105232"	""	""	""	0	""	""	"XOL27OHtm"
 "MAR01825"	""	"XOL7AH2tr"	""	""	""	"XOL7AH2tr"	"MNXR105233"	""	""	""	0	""	""	"XOL7AH2tr"
 "MAR01826"	""	"XOLDIOLONEtm"	""	""	""	"XOLDIOLONEtm"	"MNXR105235"	""	""	""	0	""	""	"XOLDIOLONEtm"
@@ -8640,7 +8639,6 @@ rxns	rxnKEGGID	rxnBiGGID	rxnEHMNID	rxnHepatoNET1ID	rxnREACTOMEID	rxnRecon3DID	rx
 "MAR02149"	""	"ACOAR5m"	""	""	""	"r0638"	"MNXR95373"	""	""	""	0	""	""	"r0638"
 "MAR02183"	""	"r0652"	""	""	""	"r0652"	"MNXR105364"	""	""	""	0	""	""	"r0652"
 "MAR02184"	""	"r0672"	""	""	""	"r0672"	"MNXR105366"	""	""	""	0	""	""	"r0672"
-"MAR02185"	""	""	""	""	""	"r0701"	""	""	""	""	0	""	""	"r0701"
 "MAR02186"	""	"r0707"	""	""	""	"r0707"	"MNXR95665"	""	""	""	0	""	""	"r0707"
 "MAR02187"	""	"ACOAR4m"	""	""	""	"r0735"	"MNXR95372"	""	""	""	0	"RHEA:44963"	"RHEA:44960"	"r0735"
 "MAR02188"	""	"r0752"	""	""	""	"r0752"	"MNXR94840"	""	""	""	0	""	""	"r0752"
@@ -10253,12 +10251,9 @@ rxns	rxnKEGGID	rxnBiGGID	rxnEHMNID	rxnHepatoNET1ID	rxnREACTOMEID	rxnRecon3DID	rx
 "MAR10463"	""	""	""	""	""	"INDOLEup"	""	""	""	""	0	""	""	"INDOLEup"
 "MAR10464"	""	""	""	""	""	"INDSt"	""	""	""	""	0	""	""	"INDSt"
 "MAR10465"	""	"PCRESOLup"	""	""	""	"PCRESOLup"	""	""	""	""	0	""	""	"PCRESOLup"
-"MAR10466"	""	"PCSsec"	""	""	""	"PCSsec"	""	""	""	""	0	""	""	"PCSsec"
-"MAR10467"	""	""	""	""	""	"PCSup"	""	""	""	""	0	""	""	"PCSup"
-"MAR10468"	""	""	""	""	""	"3HCINNMup"	""	""	""	""	0	""	""	"3HCINNMup"
-"MAR10469"	""	""	""	""	""	"3HCINNMsec"	""	""	""	""	0	""	""	"3HCINNMsec"
-"MAR10470"	""	""	""	""	""	"3HPPAup"	""	""	""	""	0	""	""	"3HPPAup"
-"MAR10471"	""	""	""	""	""	"3HPPAsec"	""	""	""	""	0	""	""	"3HPPAsec"
+"MAR10466"	""	"PCSsec"	""	""	""	"PCSsec;PCSup"	""	""	""	""	0	""	""	"PCSsec;PCSup"
+"MAR10468"	""	""	""	""	""	"3HCINNMup;3HCINNMsec"	""	""	""	""	0	""	""	"3HCINNMup;3HCINNMsec"
+"MAR10470"	""	""	""	""	""	"3HPPAup;3HPPAsec"	""	""	""	""	0	""	""	"3HPPAup;3HPPAsec"
 "MAR10472"	""	""	""	""	""	"EX_3hcinnm[e]"	""	""	""	""	0	""	""	"EX_3hcinnm[e]"
 "MAR10473"	""	""	""	""	""	"EX_3hppa[e]"	""	""	""	""	0	""	""	"EX_3hppa[e]"
 "MAR10474"	""	"EX_bgly_e"	""	""	""	"EX_bgly[e]"	""	""	""	""	0	""	""	"EX_bgly[e]"
@@ -11365,10 +11360,10 @@ rxns	rxnKEGGID	rxnBiGGID	rxnEHMNID	rxnHepatoNET1ID	rxnREACTOMEID	rxnRecon3DID	rx
 "MAR11580"	""	"CE7172UPKt"	""	""	""	"CE7172UPKt"	""	""	""	""	0	""	""	"CE7172UPKt"
 "MAR11581"	""	"NRVNCABCt"	""	""	""	"NRVNCABCt"	""	""	""	""	0	""	""	"NRVNCABCt"
 "MAR11582"	""	"PAFABCt"	""	""	""	"PAFABCt"	""	""	""	""	0	""	""	"PAFABCt"
-"MAR11583"	""	"PAIL_hs_SECt"	""	""	""	"PAIL_hs_SECt"	""	""	""	""	0	""	""	"PAIL_hs_SECt"
-"MAR11584"	""	"PAILPALM_HSSECt"	""	""	""	"PAILPALM_HSSECt"	""	""	""	""	0	""	""	"PAILPALM_HSSECt"
-"MAR11585"	""	"PAILR_HSSECt"	""	""	""	"PAILR_HSSECt"	""	""	""	""	0	""	""	"PAILR_HSSECt"
-"MAR11586"	""	""	""	""	""	"PAILSTE_HSSECt"	""	""	""	""	0	""	""	"PAILSTE_HSSECt"
+"MAR11583"	""	"PAIL_hs_SECt"	""	""	""	"PAIL_hs_SECt;PAIL_hs_t1e"	""	""	""	""	0	""	""	"PAIL_hs_SECt;PAIL_hs_t1e"
+"MAR11584"	""	"PAILPALM_HSSECt"	""	""	""	"PAILPALM_HSSECt;PAILPALM_HSt1e"	""	""	""	""	0	""	""	"PAILPALM_HSSECt;PAILPALM_HSt1e"
+"MAR11585"	""	"PAILR_HSSECt"	""	""	""	"PAILR_HSSECt;PAILR_HSt1e"	""	""	""	""	0	""	""	"PAILR_HSSECt;PAILR_HSt1e"
+"MAR11586"	""	""	""	""	""	"PAILSTE_HSSECt;PAILSTE_HSt1e"	""	""	""	""	0	""	""	"PAILSTE_HSSECt;PAILSTE_HSt1e"
 "MAR11587"	""	"PCHLN225_HSABCt"	""	""	""	"PCHLN225_HSABCt"	""	""	""	""	0	""	""	"PCHLN225_HSABCt"
 "MAR11588"	""	"PCHOL2LINL_HSABCt"	""	""	""	"PCHOL2LINL_HSABCt"	""	""	""	""	0	""	""	"PCHOL2LINL_HSABCt"
 "MAR11589"	""	"PCHOL2OLE_HSABCt"	""	""	""	"PCHOL2OLE_HSABCt"	""	""	""	""	0	""	""	"PCHOL2OLE_HSABCt"
@@ -11412,29 +11407,25 @@ rxns	rxnKEGGID	rxnBiGGID	rxnEHMNID	rxnHepatoNET1ID	rxnREACTOMEID	rxnRecon3DID	rx
 "MAR11627"	""	"PEPALM_HSASBCt"	""	""	""	"PEPALM_HSASBCt"	""	""	""	""	0	""	""	"PEPALM_HSASBCt"
 "MAR11628"	""	"PESTE_HSABCt"	""	""	""	"PESTE_HSABCt"	""	""	""	""	0	""	""	"PESTE_HSABCt"
 "MAR11629"	""	"SPHMYLN_HsSECt"	""	""	""	"SPHMYLN_HsSECt"	""	""	""	""	0	""	""	"SPHMYLN_HsSECt"
-"MAR11630"	""	"SPHMYLN180241_hs_SECt"	""	""	""	"SPHMYLN180241_hs_SECt"	""	""	""	""	0	""	""	"SPHMYLN180241_hs_SECt"
-"MAR11631"	""	"SPHMYLN18114_hs_SECt"	""	""	""	"SPHMYLN18114_hs_SECt"	""	""	""	""	0	""	""	"SPHMYLN18114_hs_SECt"
-"MAR11632"	""	"SPHMYLN18115_hs_SECt"	""	""	""	"SPHMYLN18115_hs_SECt"	""	""	""	""	0	""	""	"SPHMYLN18115_hs_SECt"
-"MAR11633"	""	"SPHMYLN18116_hs_SECt"	""	""	""	"SPHMYLN18116_hs_SECt"	""	""	""	""	0	""	""	"SPHMYLN18116_hs_SECt"
-"MAR11634"	""	"SPHMYLN181161_hs_SECt"	""	""	""	"SPHMYLN181161_hs_SECt"	""	""	""	""	0	""	""	"SPHMYLN181161_hs_SECt"
-"MAR11635"	""	"SPHMYLN18117_hs_SECt"	""	""	""	"SPHMYLN18117_hs_SECt"	""	""	""	""	0	""	""	"SPHMYLN18117_hs_SECt"
-"MAR11636"	""	"SPHMYLN18118_hs_SECt"	""	""	""	"SPHMYLN18118_hs_SECt"	""	""	""	""	0	""	""	"SPHMYLN18118_hs_SECt"
-"MAR11637"	""	"SPHMYLN181181_hs_SECt"	""	""	""	"SPHMYLN181181_hs_SECt"	""	""	""	""	0	""	""	"SPHMYLN181181_hs_SECt"
-"MAR11638"	""	"SPHMYLN18120_hs_SECt"	""	""	""	"SPHMYLN18120_hs_SECt"	""	""	""	""	0	""	""	"SPHMYLN18120_hs_SECt"
-"MAR11639"	""	"SPHMYLN181201_hs_SECt"	""	""	""	"SPHMYLN181201_hs_SECt"	""	""	""	""	0	""	""	"SPHMYLN181201_hs_SECt"
-"MAR11640"	""	"SPHMYLN18121_hs_SECt"	""	""	""	"SPHMYLN18121_hs_SECt"	""	""	""	""	0	""	""	"SPHMYLN18121_hs_SECt"
-"MAR11641"	""	"SPHMYLN18122_hs_SECt"	""	""	""	"SPHMYLN18122_hs_SECt"	""	""	""	""	0	""	""	"SPHMYLN18122_hs_SECt"
-"MAR11642"	""	"SPHMYLN181221_hs_SECt"	""	""	""	"SPHMYLN181221_hs_SECt"	""	""	""	""	0	""	""	"SPHMYLN181221_hs_SECt"
-"MAR11643"	""	"SPHMYLN18123_hs_SECt"	""	""	""	"SPHMYLN18123_hs_SECt"	""	""	""	""	0	""	""	"SPHMYLN18123_hs_SECt"
-"MAR11644"	""	"SPHMYLN1824_hs_SECt"	""	""	""	"SPHMYLN1824_hs_SECt"	""	""	""	""	0	""	""	"SPHMYLN1824_hs_SECt"
-"MAR11645"	""	"SPHMYLN1825_hs_SECt"	""	""	""	"SPHMYLN1825_hs_SECt"	""	""	""	""	0	""	""	"SPHMYLN1825_hs_SECt"
+"MAR11630"	""	"SPHMYLN180241_hs_SECt"	""	""	""	"SPHMYLN180241_hs_SECt;SPHMYLN180241_hs_t1"	""	""	""	""	0	""	""	"SPHMYLN180241_hs_SECt;SPHMYLN180241_hs_t1"
+"MAR11631"	""	"SPHMYLN18114_hs_SECt"	""	""	""	"SPHMYLN18114_hs_SECt;SPHMYLN18114_hs_t1"	""	""	""	""	0	""	""	"SPHMYLN18114_hs_SECt;SPHMYLN18114_hs_t1"
+"MAR11632"	""	"SPHMYLN18115_hs_SECt"	""	""	""	"SPHMYLN18115_hs_SECt;SPHMYLN18115_hs_t1"	""	""	""	""	0	""	""	"SPHMYLN18115_hs_SECt;SPHMYLN18115_hs_t1"
+"MAR11633"	""	"SPHMYLN18116_hs_SECt"	""	""	""	"SPHMYLN18116_hs_SECt;SPHMYLN18116_hs_t1"	""	""	""	""	0	""	""	"SPHMYLN18116_hs_SECt;SPHMYLN18116_hs_t1"
+"MAR11634"	""	"SPHMYLN181161_hs_SECt"	""	""	""	"SPHMYLN181161_hs_SECt;SPHMYLN181161_hs_t1"	""	""	""	""	0	""	""	"SPHMYLN181161_hs_SECt;SPHMYLN181161_hs_t1"
+"MAR11635"	""	"SPHMYLN18117_hs_SECt"	""	""	""	"SPHMYLN18117_hs_SECt;SPHMYLN18117_hs_t1"	""	""	""	""	0	""	""	"SPHMYLN18117_hs_SECt;SPHMYLN18117_hs_t1"
+"MAR11636"	""	"SPHMYLN18118_hs_SECt"	""	""	""	"SPHMYLN18118_hs_SECt;SPHMYLN18118_hs_t1"	""	""	""	""	0	""	""	"SPHMYLN18118_hs_SECt;SPHMYLN18118_hs_t1"
+"MAR11637"	""	"SPHMYLN181181_hs_SECt"	""	""	""	"SPHMYLN181181_hs_SECt;SPHMYLN181181_hs_t1"	""	""	""	""	0	""	""	"SPHMYLN181181_hs_SECt;SPHMYLN181181_hs_t1"
+"MAR11638"	""	"SPHMYLN18120_hs_SECt"	""	""	""	"SPHMYLN18120_hs_SECt;SPHMYLN18120_hs_t1"	""	""	""	""	0	""	""	"SPHMYLN18120_hs_SECt;SPHMYLN18120_hs_t1"
+"MAR11639"	""	"SPHMYLN181201_hs_SECt"	""	""	""	"SPHMYLN181201_hs_SECt;SPHMYLN181201_hs_t1"	""	""	""	""	0	""	""	"SPHMYLN181201_hs_SECt;SPHMYLN181201_hs_t1"
+"MAR11640"	""	"SPHMYLN18121_hs_SECt"	""	""	""	"SPHMYLN18121_hs_SECt;SPHMYLN18121_hs_t1"	""	""	""	""	0	""	""	"SPHMYLN18121_hs_SECt;SPHMYLN18121_hs_t1"
+"MAR11641"	""	"SPHMYLN18122_hs_SECt"	""	""	""	"SPHMYLN18122_hs_SECt;SPHMYLN18122_hs_t1"	""	""	""	""	0	""	""	"SPHMYLN18122_hs_SECt;SPHMYLN18122_hs_t1"
+"MAR11642"	""	"SPHMYLN181221_hs_SECt"	""	""	""	"SPHMYLN181221_hs_SECt;SPHMYLN181221_hs_t1"	""	""	""	""	0	""	""	"SPHMYLN181221_hs_SECt;SPHMYLN181221_hs_t1"
+"MAR11643"	""	"SPHMYLN18123_hs_SECt"	""	""	""	"SPHMYLN18123_hs_SECt;SPHMYLN18123_hs_t1"	""	""	""	""	0	""	""	"SPHMYLN18123_hs_SECt;SPHMYLN18123_hs_t1"
+"MAR11644"	""	"SPHMYLN1824_hs_SECt"	""	""	""	"SPHMYLN1824_hs_SECt;SPHMYLN1824_hs_t1"	""	""	""	""	0	""	""	"SPHMYLN1824_hs_SECt;SPHMYLN1824_hs_t1"
+"MAR11645"	""	"SPHMYLN1825_hs_SECt"	""	""	""	"SPHMYLN1825_hs_SECt;SPHMYLN1825_hs_t1"	""	""	""	""	0	""	""	"SPHMYLN1825_hs_SECt;SPHMYLN1825_hs_t1"
 "MAR11646"	""	"3AIBt1"	""	""	""	"3AIBt1"	""	""	""	""	0	""	""	"3AIBt1"
 "MAR11647"	""	"APRGSTRNt1e"	""	""	""	"APRGSTRNt1e"	""	""	""	""	0	""	""	"APRGSTRNt1e"
 "MAR11648"	""	"DIGALSGALSIDEATPte"	""	""	""	"DIGALSGALSIDEATPte"	""	""	""	""	0	""	""	"DIGALSGALSIDEATPte"
-"MAR11649"	""	""	""	""	""	"PAIL_hs_t1e"	""	""	""	""	0	""	""	"PAIL_hs_t1e"
-"MAR11650"	""	""	""	""	""	"PAILR_HSt1e"	""	""	""	""	0	""	""	"PAILR_HSt1e"
-"MAR11651"	""	""	""	""	""	"PAILPALM_HSt1e"	""	""	""	""	0	""	""	"PAILPALM_HSt1e"
-"MAR11652"	""	""	""	""	""	"PAILSTE_HSt1e"	""	""	""	""	0	""	""	"PAILSTE_HSt1e"
 "MAR11653"	""	"PCHOL2LINL_HSt1e"	""	""	""	"PCHOL2LINL_HSt1e"	""	""	""	""	0	""	""	"PCHOL2LINL_HSt1e"
 "MAR11654"	""	"PCHOL2OLE_HSt1e"	""	""	""	"PCHOL2OLE_HSt1e"	""	""	""	""	0	""	""	"PCHOL2OLE_HSt1e"
 "MAR11655"	""	"PCHOL2STE_HSt1e"	""	""	""	"PCHOL2STE_HSt1e"	""	""	""	""	0	""	""	"PCHOL2STE_HSt1e"
@@ -11479,39 +11470,22 @@ rxns	rxnKEGGID	rxnBiGGID	rxnEHMNID	rxnHepatoNET1ID	rxnREACTOMEID	rxnRecon3DID	rx
 "MAR11694"	""	"PESTE_HSt1e"	""	""	""	"PESTE_HSt1e"	""	""	""	""	0	""	""	"PESTE_HSt1e"
 "MAR11695"	""	"SPHMYLN_HsATPte"	""	""	""	"SPHMYLN_HsATPte"	""	""	""	""	0	""	""	"SPHMYLN_HsATPte"
 "MAR11696"	""	"SPHMYLN180241_hs_ATPt"	""	""	""	"SPHMYLN180241_hs_ATPt"	""	""	""	""	0	""	""	"SPHMYLN180241_hs_ATPt"
-"MAR11697"	""	""	""	""	""	"SPHMYLN180241_hs_t1"	""	""	""	""	0	""	""	"SPHMYLN180241_hs_t1"
 "MAR11698"	""	"SPHMYLN18114_hs_ATPt"	""	""	""	"SPHMYLN18114_hs_ATPt"	""	""	""	""	0	""	""	"SPHMYLN18114_hs_ATPt"
-"MAR11699"	""	""	""	""	""	"SPHMYLN18114_hs_t1"	""	""	""	""	0	""	""	"SPHMYLN18114_hs_t1"
 "MAR11700"	""	"SPHMYLN18115_hs_ATPt"	""	""	""	"SPHMYLN18115_hs_ATPt"	""	""	""	""	0	""	""	"SPHMYLN18115_hs_ATPt"
-"MAR11701"	""	""	""	""	""	"SPHMYLN18115_hs_t1"	""	""	""	""	0	""	""	"SPHMYLN18115_hs_t1"
 "MAR11702"	""	"SPHMYLN18116_hs_ATPt"	""	""	""	"SPHMYLN18116_hs_ATPt"	""	""	""	""	0	""	""	"SPHMYLN18116_hs_ATPt"
-"MAR11703"	""	""	""	""	""	"SPHMYLN18116_hs_t1"	""	""	""	""	0	""	""	"SPHMYLN18116_hs_t1"
 "MAR11704"	""	"SPHMYLN181161_hs_ATPt"	""	""	""	"SPHMYLN181161_hs_ATPt"	""	""	""	""	0	""	""	"SPHMYLN181161_hs_ATPt"
-"MAR11705"	""	""	""	""	""	"SPHMYLN181161_hs_t1"	""	""	""	""	0	""	""	"SPHMYLN181161_hs_t1"
 "MAR11706"	""	"SPHMYLN18117_hs_ATPt"	""	""	""	"SPHMYLN18117_hs_ATPt"	""	""	""	""	0	""	""	"SPHMYLN18117_hs_ATPt"
-"MAR11707"	""	""	""	""	""	"SPHMYLN18117_hs_t1"	""	""	""	""	0	""	""	"SPHMYLN18117_hs_t1"
 "MAR11708"	""	"SPHMYLN18118_hs_ATPt"	""	""	""	"SPHMYLN18118_hs_ATPt"	""	""	""	""	0	""	""	"SPHMYLN18118_hs_ATPt"
-"MAR11709"	""	""	""	""	""	"SPHMYLN18118_hs_t1"	""	""	""	""	0	""	""	"SPHMYLN18118_hs_t1"
 "MAR11710"	""	"SPHMYLN181181_hs_ATPt"	""	""	""	"SPHMYLN181181_hs_ATPt"	""	""	""	""	0	""	""	"SPHMYLN181181_hs_ATPt"
-"MAR11711"	""	""	""	""	""	"SPHMYLN181181_hs_t1"	""	""	""	""	0	""	""	"SPHMYLN181181_hs_t1"
 "MAR11712"	""	"SPHMYLN18120_hs_ATPt"	""	""	""	"SPHMYLN18120_hs_ATPt"	""	""	""	""	0	""	""	"SPHMYLN18120_hs_ATPt"
-"MAR11713"	""	""	""	""	""	"SPHMYLN18120_hs_t1"	""	""	""	""	0	""	""	"SPHMYLN18120_hs_t1"
 "MAR11714"	""	"SPHMYLN181201_hs_ATPt"	""	""	""	"SPHMYLN181201_hs_ATPt"	""	""	""	""	0	""	""	"SPHMYLN181201_hs_ATPt"
-"MAR11715"	""	""	""	""	""	"SPHMYLN181201_hs_t1"	""	""	""	""	0	""	""	"SPHMYLN181201_hs_t1"
 "MAR11716"	""	"SPHMYLN18121_hs_ATPt"	""	""	""	"SPHMYLN18121_hs_ATPt"	""	""	""	""	0	""	""	"SPHMYLN18121_hs_ATPt"
-"MAR11717"	""	""	""	""	""	"SPHMYLN18121_hs_t1"	""	""	""	""	0	""	""	"SPHMYLN18121_hs_t1"
 "MAR11718"	""	"SPHMYLN18122_hs_ATPt"	""	""	""	"SPHMYLN18122_hs_ATPt"	""	""	""	""	0	""	""	"SPHMYLN18122_hs_ATPt"
-"MAR11719"	""	""	""	""	""	"SPHMYLN18122_hs_t1"	""	""	""	""	0	""	""	"SPHMYLN18122_hs_t1"
 "MAR11720"	""	"SPHMYLN181221_hs_ATPt"	""	""	""	"SPHMYLN181221_hs_ATPt"	""	""	""	""	0	""	""	"SPHMYLN181221_hs_ATPt"
-"MAR11721"	""	""	""	""	""	"SPHMYLN181221_hs_t1"	""	""	""	""	0	""	""	"SPHMYLN181221_hs_t1"
 "MAR11722"	""	"SPHMYLN18123_hs_ATPt"	""	""	""	"SPHMYLN18123_hs_ATPt"	""	""	""	""	0	""	""	"SPHMYLN18123_hs_ATPt"
-"MAR11723"	""	""	""	""	""	"SPHMYLN18123_hs_t1"	""	""	""	""	0	""	""	"SPHMYLN18123_hs_t1"
 "MAR11724"	""	"SPHMYLN1824_hs_ATPt"	""	""	""	"SPHMYLN1824_hs_ATPt"	""	""	""	""	0	""	""	"SPHMYLN1824_hs_ATPt"
-"MAR11725"	""	""	""	""	""	"SPHMYLN1824_hs_t1"	""	""	""	""	0	""	""	"SPHMYLN1824_hs_t1"
 "MAR11726"	""	"SPHMYLN1825_hs_ATPt"	""	""	""	"SPHMYLN1825_hs_ATPt"	""	""	""	""	0	""	""	"SPHMYLN1825_hs_ATPt"
-"MAR11727"	""	""	""	""	""	"SPHMYLN1825_hs_t1"	""	""	""	""	0	""	""	"SPHMYLN1825_hs_t1"
-"MAR11728"	""	""	""	""	""	"2HXIC_Lt1e"	""	""	""	""	0	""	""	"2HXIC_Lt1e"
-"MAR11729"	""	""	""	""	""	"2HXIC_Lt2e"	""	""	""	""	0	""	""	"2HXIC_Lt2e"
+"MAR11728"	""	""	""	""	""	"2HXIC_Lt1e;2HXIC_Lt2e"	""	""	""	""	0	""	""	"2HXIC_Lt1e;2HXIC_Lt2e"
 "MAR11730"	""	""	""	""	""	"EX_2hxic_L[e]"	""	""	""	""	0	""	""	"EX_2hxic_L[e]"
 "MAR11731"	""	"2HYDOGOAT3t"	""	""	""	"2HYDOGOAT3t"	""	""	""	""	0	""	""	"2HYDOGOAT3t"
 "MAR11732"	""	""	""	""	""	"EX_2hydog[e]"	""	""	""	""	0	""	""	"EX_2hydog[e]"
@@ -11768,21 +11742,16 @@ rxns	rxnKEGGID	rxnBiGGID	rxnEHMNID	rxnHepatoNET1ID	rxnREACTOMEID	rxnRecon3DID	rx
 "MAR11983"	""	"EX_idl_hs_e"	""	""	""	"EX_idl_hs[e]"	""	""	""	""	0	""	""	"EX_idl_hs[e]"
 "MAR11984"	""	"EX_ldl_hs_e"	""	""	""	"EX_ldl_hs[e]"	""	""	""	""	0	""	""	"EX_ldl_hs[e]"
 "MAR11985"	""	"EX_hdl_hs_e"	""	""	""	"EX_hdl_hs[e]"	""	""	""	""	0	""	""	"EX_hdl_hs[e]"
-"MAR11986"	""	""	""	""	""	"HC00005te"	""	""	""	""	0	""	""	"HC00005te"
+"MAR11986"	""	""	""	""	""	"HC00005te;HC00005t1e"	""	""	""	""	0	""	""	"HC00005te;HC00005t1e"
 "MAR11987"	""	"EX_HC00005_e"	""	""	""	"EX_HC00005[e]"	""	""	""	""	0	""	""	"EX_HC00005[e]"
-"MAR11988"	""	""	""	""	""	"HC00005t1e"	""	""	""	""	0	""	""	"HC00005t1e"
-"MAR11989"	""	""	""	""	""	"HC00006te"	""	""	""	""	0	""	""	"HC00006te"
+"MAR11989"	""	""	""	""	""	"HC00006te;HC00006t1e"	""	""	""	""	0	""	""	"HC00006te;HC00006t1e"
 "MAR11990"	""	"EX_HC00006_e"	""	""	""	"EX_HC00006[e]"	""	""	""	""	0	""	""	"EX_HC00006[e]"
-"MAR11991"	""	""	""	""	""	"HC00006t1e"	""	""	""	""	0	""	""	"HC00006t1e"
-"MAR11992"	""	""	""	""	""	"HC00007te"	""	""	""	""	0	""	""	"HC00007te"
+"MAR11992"	""	""	""	""	""	"HC00007te;HC00007t1e"	""	""	""	""	0	""	""	"HC00007te;HC00007t1e"
 "MAR11993"	""	"EX_HC00007_e"	""	""	""	"EX_HC00007[e]"	""	""	""	""	0	""	""	"EX_HC00007[e]"
-"MAR11994"	""	""	""	""	""	"HC00007t1e"	""	""	""	""	0	""	""	"HC00007t1e"
-"MAR11995"	""	""	""	""	""	"HC00008te"	""	""	""	""	0	""	""	"HC00008te"
+"MAR11995"	""	""	""	""	""	"HC00008te;HC00008t1e"	""	""	""	""	0	""	""	"HC00008te;HC00008t1e"
 "MAR11996"	""	"EX_HC00008_e"	""	""	""	"EX_HC00008[e]"	""	""	""	""	0	""	""	"EX_HC00008[e]"
-"MAR11997"	""	""	""	""	""	"HC00008t1e"	""	""	""	""	0	""	""	"HC00008t1e"
-"MAR11998"	""	""	""	""	""	"HC00009te"	""	""	""	""	0	""	""	"HC00009te"
+"MAR11998"	""	""	""	""	""	"HC00009te;HC00009t1e"	""	""	""	""	0	""	""	"HC00009te;HC00009t1e"
 "MAR11999"	""	"EX_HC00009_e"	""	""	""	"EX_HC00009[e]"	""	""	""	""	0	""	""	"EX_HC00009[e]"
-"MAR12000"	""	""	""	""	""	"HC00009t1e"	""	""	""	""	0	""	""	"HC00009t1e"
 "MAR12001"	""	"DOPASULT4"	""	""	""	"DOPASULT4"	""	""	""	""	0	""	""	"DOPASULT4"
 "MAR12002"	""	"UDPG4DOPA"	""	""	""	"UDPG4DOPA"	""	""	""	""	0	""	""	"UDPG4DOPA"
 "MAR12003"	""	"UDPG3DOPA"	""	""	""	"UDPG3DOPA"	""	""	""	""	0	""	""	"UDPG3DOPA"