GPR curation for Transport reactions (8)

[JHL-452b]

Current behavior:

45 genes are discovered to be uncorrelated with their corresponding reactions in Transport reactions.

Gene	UniProtID	Reaction	GPR	Correlation	Manually check
ENSG00000103064	Q92536	MAR05958: histidine + serine --> histidine + serine	ENSG00000021488 and ENSG00000103064 and ENSG00000138079	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103064 encodes a protein that functions as an antiporter, which exchanges cationic amino acids (like L-arginine) with neutral amino acids (such as L-leucine, L-glutamine) and sodium ions. It has specific catalytic activities involving the transport of L-arginine with various amino acids such as L-lysine, L-leucine, L-glutamine, and others. However, the provided reaction (histidine + serine --> histidine + serine) does not involve L-arginine or the specific amino acid exchanges facilitated by this antiporter. Therefore, the gene is not relevant to the reaction provided.	Yes No
ENSG00000103064	Q92536	MAR05959: histidine + methionine --> histidine + methionine	ENSG00000021488 and ENSG00000103064 and ENSG00000138079	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103064 encodes a heterodimer with SLC3A2 that functions as an antiporter for amino acids such as L-arginine and exchanges them with other amino acids like L-leucine, L-glutamine, and L-lysine, often in a sodium-dependent or sodium-independent manner. The reactions catalyzed by this gene involve the exchange of specific amino acids. However, the provided reaction, histidine + methionine --> histidine + methionine, does not involve L-arginine or any of the other amino acids mentioned in the gene's function, thus making the gene irrelevant to the given reaction.	Yes No
ENSG00000021488	P82251	MAR05962: histidine + tyrosine --> histidine + tyrosine	ENSG00000021488 and ENSG00000103064 and ENSG00000138079	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000021488 is involved in the formation of a functional transporter complex that mediates the exchange between cationic amino acids and neutral amino acids. It specifically catalyzes reactions involving amino acids such as L-arginine, L-leucine, L-histidine, L-phenylalanine, L-cysteine, L-cystine, and L-lysine. The provided reaction, "histidine + tyrosine --> histidine + tyrosine," does not involve the amino acids that this gene's transporter complex specifically exchanges and is not aligned with the catalytic activities described in the gene's annotation. Thus, the gene is not relevant to the provided reaction.	Yes
ENSG00000103064	Q92536	MAR05962: histidine + tyrosine --> histidine + tyrosine	ENSG00000021488 and ENSG00000103064 and ENSG00000138079	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000103064 primarily functions in the transport and exchange of amino acids such as L-arginine, L-lysine, L-leucine, and others in an antiporter mechanism, and is involved in nitric oxide synthesis and related physiological processes. In contrast, the reaction provided involves the transformation of histidine and tyrosine, which is not related to the functions and catalytic activities associated with the gene according to the provided annotations. Therefore, the gene and the reaction are not related.	Yes No
ENSG00000021488	P82251	MAR05966: asparagine + histidine --> asparagine + histidine	ENSG00000021488 and ENSG00000103064 and ENSG00000138079	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000021488, according to its annotation, is involved in the electrogenic exchange of cationic and neutral amino acids with specific catalytic activities involving L-arginine, L-leucine, L-histidine, L-phenylalanine, L-cysteine, L-cystine, and L-lysine. The provided reaction involves asparagine and histidine, which are not substrates specified in the gene's known catalytic activities. Therefore, the gene is not related to the provided reaction.	Yes
ENSG00000103064	Q92536	MAR05966: asparagine + histidine --> asparagine + histidine	ENSG00000021488 and ENSG00000103064 and ENSG00000138079	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000103064 is involved in the transport and exchange of amino acids such as L-arginine, L-lysine, L-leucine, L-glutamine, L-histidine, L-cysteine, and L-methionine. It does not facilitate a reaction between asparagine and histidine as described in the reaction: asparagine + histidine --> asparagine + histidine. Therefore, the gene and the specified reaction are not related.	Yes No
ENSG00000021488	P82251	MAR05967: histidine + valine --> histidine + valine	ENSG00000021488 and ENSG00000103064 and ENSG00000138079	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000021488 encodes a transporter involved in the exchange of cationic amino acids and neutral amino acids, such as L-arginine, L-leucine, L-histidine, L-phenylalanine, L-cysteine, L-cystine, and L-lysine. The catalytic activities listed involve specific exchanges of these amino acids. The provided reaction, "histidine + valine --> histidine + valine," does not involve the catalytic exchange mechanisms described for ENSG00000021488, making the gene irrelevant to the reaction.	Yes
ENSG00000103064	Q92536	MAR05968: histidine + threonine --> histidine + threonine	ENSG00000021488 and ENSG00000103064 and ENSG00000138079	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103064 encodes a protein that functions as an antiporter involved in the exchange of cationic and neutral amino acids, such as L-arginine, L-leucine, L-glutamine, and others, often in a sodium-dependent or sodium-independent manner. The functional annotations of the gene extensively describe its role in the transport of these specific amino acids but do not mention any involvement in reactions involving histidine and threonine. The provided reaction, which is histidine + threonine --> histidine + threonine, does not align with the gene's annotated catalytic activities or transport functions, indicating no relevance between them.	Yes No
ENSG00000021488	P82251	MAR05969: histidine + homoserine --> histidine + homoserine	ENSG00000021488 and ENSG00000103064 and ENSG00000138079	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000021488 encodes a protein that functions as part of a transporter complex mediating the exchange of cationic and neutral amino acids. Specifically, it catalyzes reactions involving the exchange of L-arginine with amino acids such as L-leucine, L-histidine, L-phenylalanine, L-cysteine, L-cystine, and L-lysine. The described reaction, histidine + homoserine --> histidine + homoserine, does not involve L-arginine or the amino acid exchanges facilitated by the gene's protein product, indicating no direct relevance.	Yes
ENSG00000103064	Q92536	MAR05969: histidine + homoserine --> histidine + homoserine	ENSG00000021488 and ENSG00000103064 and ENSG00000138079	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103064 encodes a protein that functions as an antiporter, exchanging cationic amino acids like L-arginine for neutral amino acids such as L-leucine and L-glutamine, and sodium ions. This antiporter activity does not align with the provided reaction, which is a transformation between histidine and homoserine. Therefore, the functions described for ENSG00000103064 do not correlate with the chemical transformation involving histidine and homoserine.	Yes No
ENSG00000103064	Q92536	MAR05972: alanine + citrulline --> alanine + citrulline	ENSG00000021488 and ENSG00000103064 and ENSG00000138079	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103064 encodes a protein that functions primarily as an antiporter, exchanging cationic amino acids like L-arginine with neutral amino acids such as L-leucine, L-glutamine, and sodium ions, or with L-lysine in a sodium-independent manner. The reactions catalyzed by this gene involve L-arginine, L-lysine, L-leucine, L-glutamine, sodium ions, L-histidine, L-cysteine, and L-methionine. However, the provided reaction, which involves the conversion of alanine and citrulline to alanine and citrulline, does not relate to the substrates or the catalytic activities described for the gene product. Therefore, the gene ENSG00000103064 is not relevant to the reaction involving alanine and citrulline.	No
ENSG00000021488	P82251	MAR05976: citrulline + tryptophan --> citrulline + tryptophan	ENSG00000021488 and ENSG00000103064 and ENSG00000138079	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000021488 encodes for a protein that mediates the electrogenic exchange between cationic amino acids and neutral amino acids, specifically involving L-arginine with various other amino acids such as L-leucine, L-histidine, L-phenylalanine, L-cysteine, L-cystine, and L-lysine. However, the reaction provided in the annotation involves citrulline and tryptophan, which are not specified as substrates or products in any of the catalytic activities of the gene's product. Therefore, the gene is not relevant to the reaction citrulline + tryptophan --> citrulline + tryptophan.	No
ENSG00000021488	P82251	MAR05978: citrulline + tyrosine --> citrulline + tyrosine	ENSG00000021488 and ENSG00000103064 and ENSG00000138079	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000021488 is involved in the exchange of cationic amino acids and neutral amino acids, such as L-arginine, L-leucine, L-histidine, L-phenylalanine, L-cysteine, L-cystine, and L-lysine, as indicated by multiple catalytic activities. The reaction provided, however, involves the exchange of citrulline and tyrosine, which are not mentioned as substrates in the gene's described activities. Therefore, the gene is not relevant to the reaction provided.	No
ENSG00000103064	Q92536	MAR05978: citrulline + tyrosine --> citrulline + tyrosine	ENSG00000021488 and ENSG00000103064 and ENSG00000138079	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103064 codes for a protein that functions as an antiporter, specifically exchanging cationic and neutral amino acids across the cellular membrane. This includes the exchange of L-arginine with various other amino acids and sodium ions. However, the provided reaction "citrulline + tyrosine --> citrulline + tyrosine" does not involve any amino acid exchange process related to the gene's function. Therefore, based on the annotation of the gene, the reaction is not related to the activities of the gene product.	No
ENSG00000021488	P82251	MAR05980: citrulline + leucine --> citrulline + leucine	ENSG00000021488 and ENSG00000103064 and ENSG00000138079	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000021488 encodes for a protein that functions as a transporter complex, mediating the electrogenic exchange between cationic amino acids and neutral amino acids. It specifically catalyzes reactions involving the exchange of L-arginine with other amino acids such as L-leucine, L-histidine, L-phenylalanine, L-cysteine, L-cystine, and L-lysine. However, the provided reaction, "citrulline + leucine --> citrulline + leucine," does not involve any amino acid exchange process or the specific amino acids mentioned in the catalytic activities of the gene encode. Hence, the gene is not relevant to the reaction provided.	No
ENSG00000021488	P82251	MAR05981: citrulline + proline --> citrulline + proline	ENSG00000021488 and ENSG00000103064 and ENSG00000138079	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000021488 encodes a protein that functions as a transporter for electrogenic exchange between cationic and neutral amino acids, specifically including reactions involving L-arginine and various other amino acids (e.g., L-leucine, L-histidine, L-phenylalanine, L-cysteine, L-cystine, L-lysine). However, the provided reaction involves citrulline and proline, which are not substrates specified in the function or catalytic activities of the encoded transporter. Thus, there is no direct relationship between the gene's annotated function and the given reaction.	No
ENSG00000103064	Q92536	MAR05981: citrulline + proline --> citrulline + proline	ENSG00000021488 and ENSG00000103064 and ENSG00000138079	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000103064 encodes a protein that functions primarily as an antiporter involved in the exchange of cationic and neutral amino acids such as L-arginine, L-lysine, L-leucine, L-glutamine, and others, often in a sodium-dependent or -independent manner. However, the reaction provided involves the conversion between citrulline and proline, which does not include any of the specified amino acids that the gene product transports. Thus, the activities and functions of the gene product do not intersect with the described reaction.	No
ENSG00000021488	P82251	MAR05982: asparagine + citrulline --> asparagine + citrulline	ENSG00000021488 and ENSG00000103064 and ENSG00000138079	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000021488 is associated with forming a functional transporter complex involved in the exchange of cationic and neutral amino acids such as L-arginine, L-leucine, L-histidine, L-phenylalanine, L-cysteine, L-cystine, and L-lysine. However, the reaction provided involves asparagine and citrulline, which are not mentioned as substrates or products in the transport activities catalyzed by the gene. Therefore, the gene is not related to the reaction provided.	No
ENSG00000103064	Q92536	MAR05982: asparagine + citrulline --> asparagine + citrulline	ENSG00000021488 and ENSG00000103064 and ENSG00000138079	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103064 encodes a protein that functions as an antiporter, primarily involved in the exchange of amino acids such as L-arginine with other neutral or cationic amino acids like L-leucine, L-glutamine, L-lysine, among others. The gene's annotated functions and catalytic activities do not include any involvement with the reaction asparagine + citrulline --> asparagine + citrulline, indicating a lack of relevance to this reaction.	No
ENSG00000021488	P82251	MAR05983: citrulline + valine --> citrulline + valine	ENSG00000021488 and ENSG00000103064 and ENSG00000138079	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000021488 is involved in the electrogenic exchange of amino acids, specifically facilitating the transport of L-arginine and other amino acids across membranes. The catalytic activities described involve exchanges such as L-arginine with L-leucine, L-histidine, L-phenylalanine, L-cysteine, L-cystine, and L-lysine. However, the reaction "citrulline + valine --> citrulline + valine" does not correspond to any of the gene's characterized activities or substrates. Therefore, based on the gene's annotation, there is no relationship between the gene ENSG00000021488 and the specified reaction.	No
ENSG00000103064	Q92536	MAR05983: citrulline + valine --> citrulline + valine	ENSG00000021488 and ENSG00000103064 and ENSG00000138079	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103064 encodes a protein that functions as an antiporter involved in the exchange of cationic and neutral amino acids, such as L-arginine, L-leucine, and L-glutamine, often in the presence of sodium ions. However, the reaction provided involves the exchange of citrulline and valine, which is not mentioned in the catalytic activities or functions of the gene. Therefore, the gene's annotated functions and the reaction are not related.	No
ENSG00000021488	P82251	MAR05985: citrulline + homoserine --> citrulline + homoserine	ENSG00000021488 and ENSG00000103064 and ENSG00000138079	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000021488 encodes a protein that functions as a transporter complex mediating the exchange of cationic and neutral amino acids. Specifically, it facilitates the exchange of L-arginine with various amino acids such as L-leucine, L-histidine, L-phenylalanine, L-cysteine, L-cystine, and L-lysine. The described reaction involves citrulline and homoserine, which are neither directly mentioned nor involved in the transporter-mediated exchanges annotated for this gene. Therefore, the gene and the reaction are not related.	No
ENSG00000103064	Q92536	MAR05989: H+ + zinc --> H+ + zinc	ENSG00000103064 or ENSG00000104635 or ENSG00000110911 or ENSG00000138821 or ENSG00000139540 or ENSG00000141424 or ENSG00000141873 or ENSG00000143570 or ENSG00000147804 or ENSG00000165794 or ENSG00000196950	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103064 is associated with the transport of amino acids, particularly the exchange of L-arginine with other amino acids such as L-lysine, L-leucine, L-glutamine, and others, often in a sodium-dependent manner. However, the reaction provided involves the interaction between H+ and zinc, which is unrelated to the transport functions of the gene. Therefore, the gene is not relevant to the reaction.	No
ENSG00000103064	Q92536	MAR05996: citrate + 3.0 Na+ --> citrate + 3.0 Na+	ENSG00000103064 or ENSG00000158296	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103064 encodes a transporter protein that primarily functions as an antiporter for cationic and neutral amino acids such as L-arginine, L-leucine, L-glutamine, isoleucine, and others, often in exchange with sodium ions. The reactions catalyzed by the protein involve specific amino acid exchanges and do not include the transport or transformation of citrate. The provided reaction involving citrate and sodium ions does not align with any of the known catalytic activities of the gene product, which pertain solely to amino acid transport. Therefore, there is no functional relevance between the gene and the provided reaction.	No
ENSG00000100156	O95907	MAR06000: acetoacetate + pyruvate <=> acetoacetate + pyruvate	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000100156 is annotated as a probable retinal pigment epithelium-specific proton-coupled L-lactate transporter, which suggests it is involved in the transport of lactate and hydrogen ions (H+) across cell membranes to maintain pH and ion homeostasis in the outer retina. The catalytic activity mentioned for this gene involves the transport of (S)-lactate and H+ ions across membranes. However, the reaction provided involves the interconversion of acetoacetate and pyruvate, which does not involve lactate or the transport of ions. Therefore, the gene's annotated function does not align with the specific reaction of acetoacetate and pyruvate, indicating no relevance between the gene and the reaction.	No
ENSG00000108932	O15403	MAR06000: acetoacetate + pyruvate <=> acetoacetate + pyruvate	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000108932 encodes a monocarboxylate transporter selective for taurine, facilitating taurine efflux or influx across the plasma membrane. It is involved in the transport of taurine, as indicated by its functional annotation and catalytic activity. However, the reaction described involves acetoacetate and pyruvate, which are not related to taurine transport. Therefore, the gene and the reaction are not related.	No
ENSG00000100156	O95907	MAR06001: acetate + acetoacetate <=> acetate + acetoacetate	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000100156 encodes a probable retinal pigment epithelium-specific proton-coupled L-lactate transporter, facilitating the transport of lactate and H(+) out of the retina. Its catalytic activity involves the transport of (S)-lactate and H(+). The provided reaction, which involves acetate and acetoacetate, is unrelated to the gene's function or catalytic activity.	No
ENSG00000141526	O15427	MAR06001: acetate + acetoacetate <=> acetate + acetoacetate	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000141526 functions as a proton-dependent transporter of monocarboxylates such as L-lactate and pyruvate, playing a predominant role in their efflux from highly glycolytic cells. The catalytic activities described involve the transport of L-lactate and pyruvate across membranes, mediated by protons. In contrast, the provided reaction involves acetate and acetoacetate, which are not substrates or products associated with the gene's transporter activity, thereby making the gene irrelevant to the given reaction.	No
ENSG00000155380	P53985	MAR06002: acetoacetate + formate <=> acetoacetate + formate	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000155380 codes for a bidirectional proton-coupled monocarboxylate transporter involved in the transport of monocarboxylates such as lactate, pyruvate, acetate, and ketone bodies across the plasma membrane. The provided reaction involves acetoacetate and formate, which do not directly relate to the gene¡¯s function of monocarboxylate transport. Therefore, the gene is not relevant to this reaction.	No
ENSG00000100156	O95907	MAR06002: acetoacetate + formate <=> acetoacetate + formate	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000100156 is described to have a function related to the transport of L-lactate and protons, specifically facilitating the movement of lactate and H(+) ions out of the retina, thus playing a role in pH and ion homeostasis. The catalytic activity involves the specific transport of (S)-lactate and protons across membranes. However, the reaction provided involves acetoacetate and formate, which are unrelated to the lactate and proton transport function of the annotated gene. Therefore, the gene is not relevant to the reaction involving acetoacetate and formate.	No
ENSG00000108932	O15403	MAR06002: acetoacetate + formate <=> acetoacetate + formate	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000108932 encodes a monocarboxylate transporter selective for taurine, facilitating its efflux or influx across the plasma membrane. The reactions it is involved in are specifically the transport of taurine, as indicated by the catalytic activity descriptions. However, the reaction in question (acetoacetate + formate <=> acetoacetate + formate) does not involve taurine and thus does not fall within the functional scope of the monocarboxylate transporter described by this gene.	No
ENSG00000141526	O15427	MAR06002: acetoacetate + formate <=> acetoacetate + formate	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000141526 encodes for a proton-dependent transporter involved in the transport of monocarboxylates such as L-lactate and pyruvate. The described catalytic activities involve the exchange of lactate and pyruvate with protons across a membrane. However, the given reaction involves acetoacetate and formate, which are not substrates or products associated with the function of the transporter encoded by this gene. Thus, there is no relevance between the gene's function and the provided reaction.	No
ENSG00000118596	O60669	MAR06002: acetoacetate + formate <=> acetoacetate + formate	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000118596 is a proton-coupled monocarboxylate symporter that facilitates the transport of monocarboxylates such as L-lactate, pyruvate, and ketone bodies across the plasma membrane. The given reaction involves the interconversion of acetoacetate and formate, which does not align with any of the catalytic activities specified for the gene. Therefore, the gene is not related to the reaction provided.	No
ENSG00000108932	O15403	MAR06003: acetoacetate + propanoate <=> acetoacetate + propanoate	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000108932 encodes for a monocarboxylate transporter selective for taurine, facilitating its efflux or influx across the plasma membrane. It is involved in taurine transport that is pH- and sodium-independent. However, the provided reaction involves acetoacetate and propanoate, which are different substrates and not related to taurine transport, thus making the gene irrelevant to the described reaction.	No
ENSG00000108932	O15403	MAR06005: acetoacetate + retinoate <=> acetoacetate + retinoate	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000108932 encodes a monocarboxylate transporter selective for taurine, and it mediates the efflux or influx of taurine across the plasma membrane, which is a pH- and sodium-independent process specific to the transport of taurine. The reaction provided, however, involves the interconversion between acetoacetate and retinoate, which is unrelated to taurine transport and does not involve the functionality described for the gene ENSG00000108932. Therefore, there is no connection between the gene's function and the provided reaction.	No
ENSG00000141526	O15427	MAR06005: acetoacetate + retinoate <=> acetoacetate + retinoate	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000141526 encodes a proton-dependent transporter of monocarboxylates such as L-lactate and pyruvate, and is involved in catalyzing reactions related to the transport of (S)-lactate and pyruvate across membranes. The provided reaction, acetoacetate + retinoate <=> acetoacetate + retinoate, does not involve any monocarboxylates or the types of substrates that the gene's protein product is known to transport, indicating no relevant connection.	No
ENSG00000118596	O60669	MAR06005: acetoacetate + retinoate <=> acetoacetate + retinoate	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000118596 encodes a proton-coupled monocarboxylate symporter that transports monocarboxylates such as L-lactate, pyruvate, and ketone bodies across the plasma membrane. The reactions described for this gene involve the transport of various substrates including pyruvate, (S)-lactate, acetoacetate, and others across cellular membranes. The provided reaction, "acetoacetate + retinoate <=> acetoacetate + retinoate," does not align with the catalytic activities of the gene, as it does not involve the transport of monocarboxylates or protons across the membrane. Instead, the reaction appears to involve a non-transmembrane exchange or transformation involving retinoate, which is not within the described functions of this gene. Therefore, the gene and the provided reaction are not related.	No
ENSG00000108932	O15403	MAR06006: 2-hydroxybutyrate + acetoacetate <=> 2-hydroxybutyrate + acetoacetate	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000108932 encodes a monocarboxylate transporter that specifically facilitates the transport of taurine across the plasma membrane. The described reaction involves the transport of taurine and is not related to the reaction provided, which involves the interconversion of 2-hydroxybutyrate and acetoacetate. Therefore, the gene's function in taurine transport does not pertain to the provided chemical reaction.	No
ENSG00000100156	O95907	MAR06008: 2-hydroxybutyrate + acetate <=> 2-hydroxybutyrate + acetate	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000100156 encodes for a probable retinal pigment epithelium-specific proton-coupled L-lactate transporter involved in the transport of lactate and protons across the retina, playing a role in pH and ion homeostasis. The catalytic activity mentioned is the transport of L-lactate coupled with protons. The reaction provided, however, involves the interconversion of 2-hydroxybutyrate and acetate, which is unrelated to the transportation of lactate or protons. Thus, the gene's function does not align with the reaction specified.	No
ENSG00000141526	O15427	MAR06008: 2-hydroxybutyrate + acetate <=> 2-hydroxybutyrate + acetate	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000141526 encodes for a proton-dependent transporter of monocarboxylates such as L-lactate and pyruvate, facilitating their transport across the cell membrane. However, the provided reaction, "2-hydroxybutyrate + acetate <=> 2-hydroxybutyrate + acetate," does not involve the transport of L-lactate or pyruvate but rather a simple chemical equilibrium of 2-hydroxybutyrate and acetate. Thus, the gene's function and catalytic activities are not relevant to the reaction provided.	No
ENSG00000108932	O15403	MAR06009: 2-hydroxybutyrate + formate <=> 2-hydroxybutyrate + formate	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000108932 is annotated to facilitate the transport of taurine across the plasma membrane, specifically involving the reaction of taurine(out) = taurine(in). The provided reaction, 2-hydroxybutyrate + formate <=> 2-hydroxybutyrate + formate, does not involve taurine and instead deals with a different set of compounds. Therefore, the gene's function as a monocarboxylate transporter for taurine is not pertinent to this reaction.	No
ENSG00000141526	O15427	MAR06009: 2-hydroxybutyrate + formate <=> 2-hydroxybutyrate + formate	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000141526 encodes a proton-dependent transporter involved in the transport of monocarboxylates such as L-lactate and pyruvate. It catalyzes reactions involving L-lactate and pyruvate, facilitating their movement across the cell membrane with associated proton transfer. However, the reaction provided involves the interconversion of 2-hydroxybutyrate and formate, which are not substrates of the transporter encoded by this gene. Therefore, the gene is not relevant to the specified reaction.	No
ENSG00000100156	O95907	MAR06010: 2-hydroxybutyrate + propanoate <=> 2-hydroxybutyrate + propanoate	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000100156 encodes a protein involved in the proton-coupled transport of L-lactate, which facilitates the transport of lactate and H(+) out of the retina for pH and ion homeostasis. The annotated catalytic activity describes a reaction involving L-lactate and H(+). However, the provided reaction involves 2-hydroxybutyrate and propanoate, which are not substrates or products associated with the gene's annotated function. Therefore, the gene and the reaction are not related.	No
ENSG00000155380	P53985	MAR06012: 2-hydroxybutyrate + butyrate <=> 2-hydroxybutyrate + butyrate	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000155380 encodes for a bidirectional proton-coupled monocarboxylate transporter, which specifically catalyzes the transport of various monocarboxylates such as lactate, pyruvate, acetate, acetoacetate, beta-hydroxybutyrate, succinate, and other similar compounds across the plasma membrane. The annotated catalytic activities of this transporter involve the exchange of these monocarboxylates coupled with protons. However, the described reaction "2-hydroxybutyrate + butyrate <=> 2-hydroxybutyrate + butyrate" does not involve the transport of monocarboxylates across a membrane or the coupling with protons. Therefore, based on the function and catalytic activities annotated for the gene, it is not relevant to the provided reaction.	No
ENSG00000108932	O15403	MAR06012: 2-hydroxybutyrate + butyrate <=> 2-hydroxybutyrate + butyrate	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000108932 encodes a monocarboxylate transporter that is selective for taurine, facilitating the efflux or influx of taurine across the plasma membrane. The provided reaction involves the interconversion of 2-hydroxybutyrate and butyrate, which does not involve taurine transport. Therefore, the gene's function and the provided reaction are unrelated.	No

[hhl-24]

Remove ENSG00000103064 for MAR05958: histidine + serine --> histidine + serine, MAR05959: histidine + methionine --> histidine + methionine, MAR05962: histidine + tyrosine --> histidine + tyrosine, MAR05966: asparagine + histidine --> asparagine + histidine, MAR05968: histidine + threonine --> histidine + threonine, MAR05969: histidine + homoserine --> histidine + homoserine, all of these reaactions seem to be in a sodium-dependent manner.