GPR curation for Carnitine shuttle (3)

[JHL-452b]

Current behavior:

30 genes are discovered to be uncorrelated with their corresponding reactions in Carnitine shuttle.

Gene	UniProtID	Reaction	GPR	Correlation	Manually check
ENSG00000149742	Q8IVM8	MAR02703: docosanoylcarnitine + L-carnitine <=> docosanoylcarnitine + L-carnitine	ENSG00000149742 or ENSG00000175003 or ENSG00000178537 or ENSG00000197119 or ENSG00000197208	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000149742 encodes a sodium-independent organic anion transporter specifically involved in the exchange of sulfated organic components and short-chain fatty acids such as butanoate, propanoate, and pentanoate. The reactions it catalyzes mainly involve estrone 3-sulfate and dehydroepiandrosterone sulfate. However, the provided reaction involves docosanoylcarnitine and L-carnitine, which are not related to the substrates or catalytic activities described for the gene ENSG00000149742. Therefore, there is no functional relevance between the gene and the provided reaction.	No
ENSG00000197119	Q8N8R3	MAR02703: docosanoylcarnitine + L-carnitine <=> docosanoylcarnitine + L-carnitine	ENSG00000149742 or ENSG00000175003 or ENSG00000178537 or ENSG00000197119 or ENSG00000197208	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000197119 functions as a mitochondrial transporter for basic amino acids such as arginine, lysine, homoarginine, methylarginine, ornithine, and histidine. The catalytic activities listed involve the exchange or uniport of these amino acids. However, the reaction provided involves docosanoylcarnitine and L-carnitine. According to the gene function and catalytic activities, this gene does not transport carnitine nor acylcarnitines, indicating that it does not play any role in the provided reaction.	No
ENSG00000149742	Q8IVM8	MAR02706: docosenoylcarnitine + L-carnitine <=> docosenoylcarnitine + L-carnitine	ENSG00000149742 or ENSG00000175003 or ENSG00000178537 or ENSG00000197119 or ENSG00000197208	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: Based on the annotation of the gene ENSG00000149742, this gene encodes a sodium-independent organic anion transporter with specificity for sulfated conjugates of xenobiotics and steroid hormones such as estrone 3-sulfate and dehydroepiandrosterone sulfate. It can transport these molecules in exchange for short-chain fatty acids like butanoate, propanoate, and pentanoate. The provided reaction involves docosenoylcarnitine and L-carnitine, which are not mentioned within the gene's specific substrate profile. Thus, the gene ENSG00000149742 is not relevant to this reaction.	No
ENSG00000197119	Q8N8R3	MAR02706: docosenoylcarnitine + L-carnitine <=> docosenoylcarnitine + L-carnitine	ENSG00000149742 or ENSG00000175003 or ENSG00000178537 or ENSG00000197119 or ENSG00000197208	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000197119 encodes a mitochondrial transporter that specifically transports arginine, lysine, homoarginine, methylarginine, and to a lesser extent ornithine and histidine. It does not transport carnitine or acylcarnitines. Therefore, it is not related to the reaction involving docosenoylcarnitine and L-carnitine.	No
ENSG00000149742	Q8IVM8	MAR02709: docosenoylcarnitine(11) + L-carnitine <=> docosenoylcarnitine(11) + L-carnitine	ENSG00000149742 or ENSG00000175003 or ENSG00000178537 or ENSG00000197119 or ENSG00000197208	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000149742 encodes a sodium-independent organic anion transporter that is specific for sulfated conjugates of xenobiotics and steroid hormones, such as estrone 3-sulfate and dehydroepiandrosterone sulfate. The catalytic activities related to this gene involve the transport and exchange of these sulfated organic components against short-chain fatty acids like butanoate, propanoate, and pentanoate. In contrast, the reaction provided involves docosenoylcarnitine and L-carnitine, which are not related to the substrates and transport functions associated with the gene's encoded protein. Thus, there is no connection between the gene and the reaction.	No
ENSG00000197119	Q8N8R3	MAR02709: docosenoylcarnitine(11) + L-carnitine <=> docosenoylcarnitine(11) + L-carnitine	ENSG00000149742 or ENSG00000175003 or ENSG00000178537 or ENSG00000197119 or ENSG00000197208	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000197119 encodes a mitochondrial transporter that specifically transports arginine, lysine, homoarginine, methylarginine, and to a lesser extent, ornithine and histidine, but does not transport carnitine or acylcarnitines. The provided reaction involves docosenoylcarnitine and L-carnitine, which are not substrates for the mitochondrial transporter encoded by this gene. Therefore, the gene is not related to the reaction involving docosenoylcarnitine and L-carnitine.	No
ENSG00000149742	Q8IVM8	MAR02712: L-carnitine + octadecatrienoylcarnitine <=> L-carnitine + octadecatrienoylcarnitine	ENSG00000149742 or ENSG00000175003 or ENSG00000178537 or ENSG00000197119 or ENSG00000197208	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000149742 functions as a sodium-independent organic anion transporter with specificity for sulfated conjugates of xenobiotics and steroid hormones, and its catalytic activities involve the transport of compounds such as estrone 3-sulfate and dehydroepiandrosterone sulfate in exchange for short-chain fatty acids like butanoate, propanoate, and pentanoate. However, the provided reaction involves L-carnitine and octadecatrienoylcarnitine, which are not related to the substrates transported by the gene product. Therefore, the gene and the reaction are not related.	No
ENSG00000197119	Q8N8R3	MAR02712: L-carnitine + octadecatrienoylcarnitine <=> L-carnitine + octadecatrienoylcarnitine	ENSG00000149742 or ENSG00000175003 or ENSG00000178537 or ENSG00000197119 or ENSG00000197208	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000197119 encodes for a mitochondrial transporter responsible for the transport of basic amino acids such as arginine, lysine, homoarginine, methylarginine, ornithine, and histidine. The gene's associated reactions involve the exchange or transport of these specific amino acids across the mitochondrial membrane. However, the provided reaction involves the transport of L-carnitine and octadecatrienoylcarnitine, which the gene's product does not transport, as it explicitly states that the transporter does not carry carnitine or acylcarnitines. Therefore, the gene is not related to the given reaction.	No
ENSG00000197119	Q8N8R3	MAR02715: (6Z,9Z,12Z,15Z)-octadecatetraenoylcarnitine + L-carnitine <=> (6Z,9Z,12Z,15Z)-octadecatetraenoylcarnitine + L-carnitine	ENSG00000149742 or ENSG00000175003 or ENSG00000178537 or ENSG00000197119 or ENSG00000197208	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000197119 encodes a mitochondrial transporter that is involved in the transport of basic amino acids such as arginine, lysine, homoarginine, methylarginine, ornithine, and histidine. The catalytic activities mentioned involve exchanges and uniport mechanisms specific to these amino acids. However, the provided reaction involves (6Z,9Z,12Z,15Z)-octadecatetraenoylcarnitine and L-carnitine, which this gene does not transport according to the provided functional annotation and evidence from PubMed studies.	No
ENSG00000149742	Q8IVM8	MAR02718: (8Z,11Z,14Z,17Z)-eicosatetraenoylcarnitine + L-carnitine <=> (8Z,11Z,14Z,17Z)-eicosatetraenoylcarnitine + L-carnitine	ENSG00000149742 or ENSG00000175003 or ENSG00000178537 or ENSG00000197119 or ENSG00000197208	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000149742 encodes a sodium-independent organic anion transporter that is specifically involved in the transport of sulfated conjugates of xenobiotics and steroid hormones, such as estrone 3-sulfate and dehydroepiandrosterone sulfate, in exchange for short-chain fatty acids. The detailed catalytic activities indicate exchange reactions involving butanoate, propanoate, and pentanoate with these steroid sulfates. However, the reaction provided involves (8Z,11Z,14Z,17Z)-eicosatetraenoylcarnitine and L-carnitine, which are not substrates or products associated with the known function and transport specificity of the gene's encoded protein. Therefore, the gene is not relevant to the provided reaction.	No
ENSG00000197119	Q8N8R3	MAR02718: (8Z,11Z,14Z,17Z)-eicosatetraenoylcarnitine + L-carnitine <=> (8Z,11Z,14Z,17Z)-eicosatetraenoylcarnitine + L-carnitine	ENSG00000149742 or ENSG00000175003 or ENSG00000178537 or ENSG00000197119 or ENSG00000197208	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000197119 encodes for a mitochondrial transporter responsible for the transport of arginine, lysine, homoarginine, methylarginine, ornithine, and histidine, but not carnitine or acylcarnitines as evidenced by multiple PubMed references. The gene's catalytic activities involve various amino acid exchanges, none of which include interactions with carnitine or acylcarnitines. Therefore, the reaction involving (8Z,11Z,14Z,17Z)-eicosatetraenoylcarnitine and L-carnitine is not related to the gene product of ENSG00000197119.	No
ENSG00000197119	Q8N8R3	MAR02727: (7Z,10Z,13Z,16Z,19Z)-docosapentaenoylcarnitine + L-carnitine <=> (7Z,10Z,13Z,16Z,19Z)-docosapentaenoylcarnitine + L-carnitine	ENSG00000149742 or ENSG00000175003 or ENSG00000178537 or ENSG00000197119 or ENSG00000197208	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000197119 encodes a mitochondrial transporter involved in the transport of basic amino acids such as arginine, lysine, homoarginine, methylarginine, and to a lesser extent, ornithine and histidine. It does not transport carnitine or acylcarnitines. The provided reaction involves the exchange of docosapentaenoylcarnitine and L-carnitine, substances the gene product does not transport according to its annotated functions. Thus, the gene is not related to the given reaction.	No
ENSG00000149742	Q8IVM8	MAR02731: docosahexaenoylcarnitine + L-carnitine <=> docosahexaenoylcarnitine + L-carnitine	ENSG00000149742 or ENSG00000175003 or ENSG00000178537 or ENSG00000197119 or ENSG00000197208	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000149742 encodes a sodium-independent organic anion transporter that specifically facilitates the exchange of sulfated conjugates and short-chain fatty acids, such as butanoate, propanoate, and pentanoate, for compounds like estrone 3-sulfate and dehydroepiandrosterone sulfate. The annotated catalytic activities involve the transport of these molecules, which differ from the provided reaction that involves the compounds docosahexaenoylcarnitine and L-carnitine. Thus, the function and catalytic activities of the gene's product do not align with the provided reaction.	No
ENSG00000197119	Q8N8R3	MAR02731: docosahexaenoylcarnitine + L-carnitine <=> docosahexaenoylcarnitine + L-carnitine	ENSG00000149742 or ENSG00000175003 or ENSG00000178537 or ENSG00000197119 or ENSG00000197208	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000197119 encodes a mitochondrial transporter involved in the transport of basic amino acids (such as arginine, lysine, homoarginine, methylarginine, ornithine, and histidine) across the mitochondrial membrane. The reactions it catalyzes involve the exchange of these amino acids between the inside and outside of the mitochondria. However, the provided reaction involves the exchange of docosahexaenoylcarnitine and L-carnitine, which are not substrates transported by the protein encoded by this gene. Additionally, it is explicitly stated that the gene does not transport carnitine or acylcarnitines. Hence, the gene and the reaction are not related.	No
ENSG00000197208	Q9H015	MAR02734: (11Z,14Z,17Z)-eicosatrienoylcarnitine + L-carnitine <=> (11Z,14Z,17Z)-eicosatrienoylcarnitine + L-carnitine	ENSG00000149742 or ENSG00000175003 or ENSG00000178537 or ENSG00000197119 or ENSG00000197208	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000197208 encodes a transporter protein that mediates the transport of endogenous and microbial zwitterions and organic cations, such as ergothioneine, acetylcholine, L-carnitine, and glycine betaine. However, the reaction specified is (11Z,14Z,17Z)-eicosatrienoylcarnitine with L-carnitine, which is not mentioned among the transport or catalytic activities associated with this gene. Therefore, based on the provided gene function, it does not appear to be relevant to this specific reaction.	No Yes
ENSG00000149742	Q8IVM8	MAR02734: (11Z,14Z,17Z)-eicosatrienoylcarnitine + L-carnitine <=> (11Z,14Z,17Z)-eicosatrienoylcarnitine + L-carnitine	ENSG00000149742 or ENSG00000175003 or ENSG00000178537 or ENSG00000197119 or ENSG00000197208	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000149742 encodes a sodium-independent organic anion transporter that specifically transports sulfated conjugates of xenobiotics and steroid hormones (such as estrone 3-sulfate and dehydroepiandrosterone sulfate) and can facilitate the transport of short-chain fatty acids. The described reaction involves the transport of (11Z,14Z,17Z)-eicosatrienoylcarnitine and L-carnitine, which are not substrates mentioned in the gene¡¯s function. Therefore, the gene's annotated function does not align with the reaction involving (11Z,14Z,17Z)-eicosatrienoylcarnitine and L-carnitine.	No
ENSG00000175003	O15245	MAR02734: (11Z,14Z,17Z)-eicosatrienoylcarnitine + L-carnitine <=> (11Z,14Z,17Z)-eicosatrienoylcarnitine + L-carnitine	ENSG00000149742 or ENSG00000175003 or ENSG00000178537 or ENSG00000197119 or ENSG00000197208	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000175003 encodes a transporter involved in the bidirectional transport of a variety of organic cations such as bioactive amines, neurotransmitters, cationic drugs, and xenobiotics across cell membranes. The specific catalytic activities listed for this gene include the transport of compounds like dopamine, serotonin, adrenaline, histamine, acetylcholine, thiamine, and others, but there is no mention of involvement in the reaction involving (11Z,14Z,17Z)-eicosatrienoylcarnitine and L-carnitine. Therefore, based on the gene¡¯s function and associated catalytic activities, it is not related to the given reaction.	No
ENSG00000197119	Q8N8R3	MAR02734: (11Z,14Z,17Z)-eicosatrienoylcarnitine + L-carnitine <=> (11Z,14Z,17Z)-eicosatrienoylcarnitine + L-carnitine	ENSG00000149742 or ENSG00000175003 or ENSG00000178537 or ENSG00000197119 or ENSG00000197208	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000197119 encodes a mitochondrial transporter involved in the transport of basic amino acids such as arginine, lysine, homoarginine, methylarginine, ornithine, and histidine, and does not transport carnitine nor acylcarnitines based on the literature cited. The reaction provided involves the exchange of eicosatrienoylcarnitine and L-carnitine, which are not substrates that the encoded transporter moves according to its described functions and annotated catalytic activities. Therefore, there is no relevance between the gene's encoded transporter and the provided reaction.	No
ENSG00000149742	Q8IVM8	MAR02737: 13,16,19-docosatrienoylcarnitine + L-carnitine <=> 13,16,19-docosatrienoylcarnitine + L-carnitine	ENSG00000149742 or ENSG00000175003 or ENSG00000178537 or ENSG00000197119 or ENSG00000197208	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000149742 encodes a sodium-independent organic anion transporter that specifically facilitates the transport of sulfated conjugates of xenobiotics and steroid hormones, such as estrone 3-sulfate and dehydroepiandrosterone sulfate, in exchange for short-chain fatty acids like butanoate, propanoate, and pentanoate. The reactions supported by this transporter involve these substrates. However, the provided reaction involves an exchange between 13,16,19-docosatrienoylcarnitine and L-carnitine, which are not substrates mentioned in the function or catalytic activity of the encoded protein. Therefore, the gene and the reaction are not related.	No
ENSG00000197119	Q8N8R3	MAR02737: 13,16,19-docosatrienoylcarnitine + L-carnitine <=> 13,16,19-docosatrienoylcarnitine + L-carnitine	ENSG00000149742 or ENSG00000175003 or ENSG00000178537 or ENSG00000197119 or ENSG00000197208	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000197119 codes for a mitochondrial transporter protein involved in the import and exchange of basic amino acids such as arginine, lysine, homoarginine, methylarginine, ornithine, and histidine, as supported by its annotated functions and catalytic activities. The provided reaction, however, involves the exchange of 13,16,19-docosatrienoylcarnitine and L-carnitine, which are not substrates or products associated with the gene's functions. Therefore, based on the gene's annotation, there is no relevance between the gene and the provided reaction.	No
ENSG00000197119	Q8N8R3	MAR02740: 10,13,16,19-docosatetraenoylcarnitine + L-carnitine <=> 10,13,16,19-docosatetraenoylcarnitine + L-carnitine	ENSG00000149742 or ENSG00000175003 or ENSG00000178537 or ENSG00000197119 or ENSG00000197208	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. Based on the provided annotation, the gene ENSG00000197119 encodes a mitochondrial transporter involved in the transport of arginine, lysine, homoarginine, methylarginine, histidine, and to a lesser extent, ornithine. It does not transport carnitine nor acylcarnitines. The reaction provided involves 10,13,16,19-docosatetraenoylcarnitine and L-carnitine, which are not substrates or products mentioned in the gene's function or catalytic activities. Therefore, the gene is not relevant to the reaction provided.	No
ENSG00000197119	Q8N8R3	MAR02744: L-carnitine + linoleic-carnitine <=> L-carnitine + linoleic-carnitine	ENSG00000149742 or ENSG00000175003 or ENSG00000178537 or ENSG00000197119 or ENSG00000197208	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000197119 functions as a mitochondrial transporter of basic amino acids such as arginine, lysine, homoarginine, methylarginine, ornithine, and histidine. It explicitly does not transport carnitine or acylcarnitines, as supported by multiple studies (PubMed:19287344, PubMed:24652292). The provided reaction involves L-carnitine and linoleic-carnitine, which are not substrates of the transporter encoded by this gene. Therefore, the gene is unrelated to this reaction.	No
ENSG00000149742	Q8IVM8	MAR02748: gamma-linolenoylcarnitine + L-carnitine <=> gamma-linolenoylcarnitine + L-carnitine	ENSG00000149742 or ENSG00000175003 or ENSG00000178537 or ENSG00000197119 or ENSG00000197208	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000149742 encodes for a sodium-independent organic anion transporter, which is involved in the transport of sulfated conjugates of xenobiotics and steroid hormones, such as estrone 3-sulfate (E1S) and dehydroepiandrosterone sulfate (DHEAS), as well as short-chain fatty acids (SCFAs) like butanoate, propanoate, and pentanoate. It functions by exchanging these organic anions against SCFAs at the sinusoidal membrane of hepatocytes. However, the provided reaction involving "gamma-linolenoylcarnitine + L-carnitine <=> gamma-linolenoylcarnitine + L-carnitine" does not involve any of the substrates or products associated with the function or catalytic activities cited in the gene's annotation. Therefore, the gene does not relate to this specific reaction.	No
ENSG00000197119	Q8N8R3	MAR02748: gamma-linolenoylcarnitine + L-carnitine <=> gamma-linolenoylcarnitine + L-carnitine	ENSG00000149742 or ENSG00000175003 or ENSG00000178537 or ENSG00000197119 or ENSG00000197208	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000197119 encodes for a mitochondrial transporter that primarily facilitates the transport of basic amino acids such as arginine, lysine, homoarginine, methylarginine, ornithine, and histidine, but does not transport carnitine or acylcarnitines, as indicated by multiple sources (PubMed:19287344, PubMed:24652292). The provided reaction involves gamma-linolenoylcarnitine and L-carnitine, which are substances the gene product specifically does not transport according to the text. Therefore, the gene and the reaction are not related.	No
ENSG00000149742	Q8IVM8	MAR02753: eicosatrienoylcarnitine + L-carnitine <=> eicosatrienoylcarnitine + L-carnitine	ENSG00000149742 or ENSG00000175003 or ENSG00000178537 or ENSG00000197119 or ENSG00000197208	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000149742 is annotated as a sodium-independent organic anion transporter specifically involved in the transport of sulfated conjugates of xenobiotics and steroid hormones such as estrone 3-sulfate and dehydroepiandrosterone sulfate. It operates through exchanging these sulfated organic components against short-chain fatty acids such as butanoate, propanoate, and pentanoate. However, the provided reaction involves the exchange of eicosatrienoylcarnitine and L-carnitine, which are not relevant to the substrates and activities associated with this gene. Therefore, the gene does not relate to the provided reaction.	No
ENSG00000197119	Q8N8R3	MAR02753: eicosatrienoylcarnitine + L-carnitine <=> eicosatrienoylcarnitine + L-carnitine	ENSG00000149742 or ENSG00000175003 or ENSG00000178537 or ENSG00000197119 or ENSG00000197208	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000197119 encodes a mitochondrial transporter responsible for the transport of specific basic amino acids such as arginine, lysine, homoarginine, methylarginine, ornithine, and histidine, utilizing counter-exchange and uniport mechanisms. The annotated catalytic activities of this transporter involve the exchange or transport of these amino acids. However, the reaction provided involves the exchange between eicosatrienoylcarnitine and L-carnitine. The gene's function explicitly states that it does not transport carnitine nor acylcarnitines, which are the substrates in the given reaction. Therefore, the gene and the reaction are not related.	No
ENSG00000149742	Q8IVM8	MAR02757: arachidonyl-carnitine + L-carnitine <=> arachidonyl-carnitine + L-carnitine	ENSG00000149742 or ENSG00000175003 or ENSG00000178537 or ENSG00000197119 or ENSG00000197208	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000149742 encodes a sodium-independent organic anion transporter with a high specificity for sulfated conjugates of xenobiotics and steroid hormones, such as estrone 3-sulfate and dehydroepiandrosterone sulfate. It facilitates the exchange of sulfated organic compounds with short-chain fatty acids, specifically butanoate, propanoate, and pentanoate. The gene's annotated catalytic activities do not include any reactions involving arachidonyl-carnitine and L-carnitine. Therefore, it is unrelated to the reaction involving arachidonyl-carnitine and L-carnitine.	No
ENSG00000149742	Q8IVM8	MAR02760: L-carnitine + ocosatetraenoylcarnitine <=> L-carnitine + ocosatetraenoylcarnitine	ENSG00000149742 or ENSG00000175003 or ENSG00000178537 or ENSG00000197119 or ENSG00000197208	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The annotation of gene ENSG00000149742 indicates that it functions as a sodium-independent organic anion transporter with specificity for sulfated conjugates of xenobiotics and steroid hormones such as estrone 3-sulfate and dehydroepiandrosterone sulfate. Its catalytic activities include the transport of these sulfated compounds and short-chain fatty acids like butanoate, propanoate, and pentanoate across hepatocyte membranes. However, the reaction provided¡ªL-carnitine + ocosatetraenoylcarnitine <=> L-carnitine + ocosatetraenoylcarnitine¡ªdoes not involve any sulfated conjugates, xenobiotics, or fatty acids, nor does it pertain to the exchange activities described for the gene. Thus, the gene and the reaction are not related.	No
ENSG00000197119	Q8N8R3	MAR02760: L-carnitine + ocosatetraenoylcarnitine <=> L-carnitine + ocosatetraenoylcarnitine	ENSG00000149742 or ENSG00000175003 or ENSG00000178537 or ENSG00000197119 or ENSG00000197208	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000197119 is involved in the mitochondrial transport of specific amino acids such as arginine, lysine, homoarginine, methylarginine, ornithine, and histidine. It does not transport carnitine or acylcarnitines, as confirmed by PubMed:24652292. The reaction provided involves L-carnitine and ocosatetraenoylcarnitine, which are not substrates for the transporter encoded by this gene. Therefore, there is no relation between the gene and the reaction provided.	No
ENSG00000197119	Q8N8R3	MAR02764: (4Z,7Z,10Z,13Z,16Z)-docosapentaenoylcarnitine + L-carnitine <=> (4Z,7Z,10Z,13Z,16Z)-docosapentaenoylcarnitine + L-carnitine	ENSG00000149742 or ENSG00000175003 or ENSG00000178537 or ENSG00000197119 or ENSG00000197208	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000197119 encodes a mitochondrial transporter specific for several basic amino acids including arginine, lysine, homoarginine, methylarginine, ornithine, and histidine. It does not transport carnitine or acylcarnitines. The described reaction involves the exchange of (4Z,7Z,10Z,13Z,16Z)-docosapentaenoylcarnitine and L-carnitine, which are not substrates for the transporter encoded by ENSG00000197119. Therefore, the gene is not relevant to the reaction.	No

[feiranl]

Please Retain ENSG00000197208 for MAR02734, as it may function as a low-affinity, Na+-dependent transporter of L-carnitine across the mitochondrial membrane, thereby supporting intracellular carnitine homeostasis (PubMed:10215651, PubMed:15107849, PubMed:16729965).

LGTM! This issue is the same with last one, since three genes (ENSG00000197119 ENSG00000149742 ENSG00000175003) cannot transport L-carnitine.

[JHL-452b]

Fixed by #923