diff --git a/README.md b/README.md
index 552eabda..b2e6f9ee 100644
--- a/README.md
+++ b/README.md
@@ -27,7 +27,7 @@ This repository contains the latest version of Human-GEM, a human genome-scale m
|Taxonomy | Template Model | Reactions | Metabolites| Genes |
| ------------- |:-------------:|:-------------:|:-------------:|:-----:|
-|_Homo sapiens_ | HMR2, Recon3D, iHsa| 13101| 8400| 3626|
+|_Homo sapiens_ | HMR2, Recon3D, iHsa| 13082| 8378| 3625|
### Administration
diff --git a/model/Human-GEM.mat b/model/Human-GEM.mat
index b7ad8b84..eff0511a 100644
Binary files a/model/Human-GEM.mat and b/model/Human-GEM.mat differ
diff --git a/model/Human-GEM.txt b/model/Human-GEM.txt
index 9445b531..aa2ae9d9 100644
--- a/model/Human-GEM.txt
+++ b/model/Human-GEM.txt
@@ -5,7 +5,7 @@ HMR_4097 m01252c + m01371c + m01597c -> m01261c + m01334c + m02759c ENSG000001
HMR_4099 m01252m + m01371m + m01597m -> m01261m + m01334m + m02759m ENSG00000111058 or ENSG00000154930 0.00 1000.00 0.00
HMR_4108 m01257c + m01597c -> m01261c + m01334c + m02039c ENSG00000131069 0.00 1000.00 0.00
HMR_4133 m01252c + m01371c + m02039c -> m01257c + m02759c ENSG00000131069 0.00 1000.00 0.00
-HMR_4137 m01597m + m02552m + m02819m -> m01261m + m01596m + m02553m ENSG00000091140 and ENSG00000110435 and ENSG00000131828 and ENSG00000150768 and ENSG00000163114 and ENSG00000168291 0.00 1000.00 0.00
+HMR_4137 m01597m + m02552m + m02819m -> m01261m + m01596m + m02553m ENSG00000091140 and ENSG00000110435 and ( ENSG00000131828 or ENSG00000163114 ) and ENSG00000150768 and ENSG00000168291 0.00 1000.00 0.00
HMR_4281 m02039p + m02553p + m02819p <=> m02403p + m02552p ENSG00000111716 or ENSG00000134333 or ENSG00000151116 or ENSG00000166796 or ENSG00000166800 or ENSG00000171989 -1000.00 1000.00 0.00
HMR_4388 m02039c + m02553c + m02819c <=> m02403c + m02552c ENSG00000111716 or ENSG00000134333 or ENSG00000151116 or ENSG00000166796 or ENSG00000166800 or ENSG00000171989 -1000.00 1000.00 0.00
HMR_4283 m01249c + m02040c + m02554c -> m01252c + 2 m02039c + m02555c ENSG00000006534 or ENSG00000108602 or ENSG00000132746 or ENSG00000184254 0.00 1000.00 0.00
@@ -574,8 +574,8 @@ HMR_4423 m02040s + m02630s + m02812s -> m00969s + m02039s + m02041s + m02578s
HMR_4424 m01303m + m02040m -> m02812m + m03121m ENSG00000116771 0.00 1000.00 0.00
HMR_4583 m01619c + m02039c + m02871c <=> m02036c + m02877c ENSG00000130005 -1000.00 1000.00 0.00
HMR_4605 m00969m + m02040m + m02554m -> m00970m + 2 m02039m + m02555m ENSG00000072210 or ENSG00000111275 or ENSG00000137124 or ENSG00000143149 or ENSG00000164904 0.00 1000.00 0.00
-HMR_4606 m00970c + m01371c + m02125c -> m01334c + 2 m02039c + m02132c + m02759c ENSG00000172508 0.00 1000.00 0.00
-HMR_4607 m02039c + m02040c + m02132c -> m00970c + m02125c ENSG00000133313 or ENSG00000150656 0.00 1000.00 0.00
+HMR_4606 m00970c + m01371c + m02125c -> m01334c + m02039c + m02132c + m02759c ENSG00000172508 0.00 1000.00 0.00
+HMR_4607 m02040c + m02132c -> m00970c + m02125c ENSG00000133313 or ENSG00000150656 0.00 1000.00 0.00
HMR_4776 m01306c + m02630c + m02770c -> m01596c + m02943c + m03037c ENSG00000072682 or ENSG00000122884 or ENSG00000149380 0.00 1000.00 0.00
HMR_4777 m01306m + m02630m + m02770m -> m01596m + m02943m + m03037m ENSG00000072682 or ENSG00000122884 or ENSG00000149380 0.00 1000.00 0.00
HMR_4778 m02552c + m03037c -> 2 m02039c + m02320c + m02553c ENSG00000104524 or ENSG00000143811 or ENSG00000183010 or ENSG00000243709 0.00 1000.00 0.00
@@ -731,7 +731,7 @@ HMR_4667 m02040m + m02552m + m02868m -> m00631m + m01974m + m02039m + m02553m
HMR_4668 m02040m + m02554m + m02868m -> m00631m + m01974m + m02039m + m02555m ENSG00000008311 0.00 1000.00 0.00
HMR_4737 m00631c + m02040c + m02552c -> 2 m02039c + m02322c + m02553c ENSG00000164904 0.00 1000.00 0.00
HMR_4739 m00631m + m02040m + m02552m -> 2 m02039m + m02322m + m02553m ENSG00000164904 0.00 1000.00 0.00
-HMR_4740 m00556c + m02039c + m02040c <=> m00631c ENSG00000079931 or ENSG00000123454 -1000.00 1000.00 0.00
+HMR_4740 m00556c + m02039c + m02040c <=> m00631c -1000.00 1000.00 0.00
HMR_6415 m01597m + m02899m -> m01701m + m01977m ENSG00000119689 0.00 1000.00 0.00
HMR_6974 m00196c + m02426c -> m00204c + m02040c 0.00 1000.00 0.00
HMR_6975 m00204c + m02877c -> m00213c + m02039c + m02871c ( ENSG00000055609 and ENSG00000272333 ) or ( ENSG00000055609 and ENSG00000167548 ) or ENSG00000005483 or ENSG00000099381 or ENSG00000101945 or ENSG00000104885 or ENSG00000109685 or ENSG00000110066 or ENSG00000116539 or ENSG00000118058 or ENSG00000133247 or ENSG00000136169 or ENSG00000139718 or ENSG00000143379 or ENSG00000145391 or ENSG00000147548 or ENSG00000152455 or ENSG00000165671 or ENSG00000170364 or ENSG00000181090 or ENSG00000181555 or ENSG00000183955 or ENSG00000185420 or ENSG00000204371 0.00 1000.00 0.00
@@ -977,7 +977,7 @@ HMR_7756 m00673c + m02040c -> m02039c + m02578c + m02720c ENSG00000165591 0.
HMR_8539 m02630c + m02724c + m02978c -> m00965c + m03101c ENSG00000171759 0.00 1000.00 0.00
HMR_8794 m01371c + m01597c + m02720c -> m01334c + m02721c + m02759c 0.00 1000.00 0.00
HMR_8795 m01975c + m02721c -> m01597c + m02722c 0.00 1000.00 0.00
-HMR_8796 m01986c + m02721c -> m01597c + m02723c ENSG00000149124 0.00 1000.00 0.00
+HMR_8796 m01986c + m02721c -> m01597c + m02039c + m02723c ENSG00000149124 0.00 1000.00 0.00
HMR_3875 m01371c + m02040c + m02471c -> m02751c + m02759c + m02877c ENSG00000038274 or ENSG00000151224 or ENSG00000168906 0.00 1000.00 0.00
HMR_3877 m02040c + m02871c -> m01280c + m02133c ENSG00000101444 or ENSG00000158467 or ENSG00000168710 0.00 1000.00 0.00
HMR_3879 m02133c + m02896c -> m02040c + m02349c ENSG00000160200 0.00 1000.00 0.00
@@ -8151,7 +8151,6 @@ vitaminE m00766c + m01924c -> m03143c 0.00 1000.00 0.00
xenobiotics m00030c + m00031c + m00033c + m00244c + m00246c + m00251c + m00539c + m00540c + m00541c + m00542c + m00543c + m00544c + m00567c + m00571c + m00637c + m00724c + m00917c + m00927c + m00928c + m00930c + m00944c + m00972c + m01156c + m01175c + m01195c + m01242c + m01297c + m01299c + m01301c + m01302c + m01376c + m01691c + m01929c + 2 m02143c + m02144c + m02589c + m02607c + m02608c + m02850c + m02853c + m02855c + m03038c + m03042c -> m10002s 0.00 1000.00 0.00
arachidonates m00005c + m00013c + m00014p + m00029c + m00254c + m00254m + m00254p + m00270c + m00270r + m00274c + m00274r + m00276c + m00277c + m00278c + m00280c + m00282c + m00284c + m00284m + m00284r + m00293c + m00297c + m00298c + m00304c + m00306c + m00308c + m00318c + m00318r + m00319c + m00320c + m00321c + m00322c + m00323c + m00323r + m00324r + m00327c + m00327r + m00328c + m00328r + m00333r + m00334c + m00336c + m00338c + m00340c + m00352r + m00354c + m00364c + m00366r + m00376c + m00378c + m00382c + m00383c + m00384c + m00386c + m00386p + m00386r + m00387c + m00387p + m00387r + m00388c + m00388p + m00388r + m00389c + m00389p + m00389r + m00392c + m00395c + m00396c + m00398p + m00414c + m00424m + m00425p + m00426c + m00428r + m00430c + m00590c + m00595c + m00595r + m00598c + m00598r + m00602c + m00687m + m00687p + m01038n + m01039p + m01041n + m01046c + m01047c + m01049c + m01050c + m01051c + m01054r + m01055c + m01120c + m01120r + m01122c + m01122r + m01150c + m01150m + m01150p + m01153c + m01153m + m01153p + m01153r + m01167c + m01168r + m01171c + m01171m + m01171p + m01172c + m01172m + m01172p + m01190c + m01202c + m01208c + m01209r + m01210c + m01213c + m01239c + m02097c + m02097p + m02368c + m02395n + m02395p + m02395r + m02396p + m02396r + m02441c + m02538c + m02538n + m02649m + m02649p + m02786r + m02787n + m02793r + m02796r + m02797c + m02798c + m02799c + m02851c + m02852c + m02862c + m02863c + m02864c + m03055c + m03055p + m03055r + m03056c -> m10003s 0.00 1000.00 0.00
steroids m00400c + m00400r + m00432r + m00604c + m00624c + m00641c + m00641m + m00641p + m00641r + m00642c + m00642m + m00642p + m00642r + m00644c + m00645c + m00649l + m00649r + m00651c + m00651m + m00651p + m00651r + m00652c + m00652m + m00652p + m00652r + m00659c + m00660c + m00660r + m00747r + m00759c + m00828r + m00830c + m00925c + m00927c + m00945c + m00947c + m00949c + m00987c + m00987m + m00987p + m00987r + m00988c + m01001c + m01001m + m01001p + m01001r + m01011c + m01012c + m01792r + m01794r + m02469c -> m10001s 0.00 1000.00 0.00
-others m00231c + m00232c + m00512c + m00527c + m00535c + m00558c + m00677c + m00684c + m00719c + m00719r + m00727c + m00732c + m00732r + m00735c + m00952c + m01059c + m01061c + m01062c + m01073p + m01101p + m01112c + m01136c + m01170n + m01179r + m01180m + m01221c + m01250c + m01250p + m01281c + m01372c + m01749c + m02025c + m02166c + m02166m + m02478c + m02484m + m02500c + m02520c + m02591c + m02681l + m02698r + m02714c + m02749c + m02865c + m02890c + m02892c + m02920c + m02920p + m02920s + m02924c + m02924p + m02964c + m02964p + m03112g + m03122c -> m10000s 0.00 1000.00 0.00
10FTHFtm m00266c <=> m00266m -1000.00 1000.00 0.00
13DAMPPOX m00248c + m02040c + m02630c -> m00760c + m02041c + m02579c ENSG00000002726 or ENSG00000131471 or ENSG00000131480 0.00 1000.00 0.00
34HPLFM m01005m + m02039m + m02553m -> m02552m + m01004m 0.00 1000.00 0.00
@@ -8882,7 +8881,7 @@ RE1527C m02552c + m00082c <=> m02039c + m02553c + m00883c -1000.00 1000.00
RE1711M m02554m + m01110m <=> m02039m + m02555m + m01102m ENSG00000147576 -1000.00 1000.00 0.00
RE1796C m02552c + m01183c <=> m01182c + m02039c + m02553c -1000.00 1000.00 0.00
RE1796M m02552m + m00592m <=> m02039m + m02553m + m01182m ENSG00000203857 or ENSG00000203859 -1000.00 1000.00 0.00
-RE1804C m02552c + CE0233_c <=> m00756c + m02039c + m02553c -1000.00 1000.00 0.00
+RE1804C m02552c + m01094c <=> m00756c + m02039c + m02553c -1000.00 1000.00 0.00
RE1804M m01093m + m02552m <=> m00756m + m02039m + m02553m ENSG00000135929 -1000.00 1000.00 0.00
RE1806C m01078c + m02039c + m02555c + m02630c -> m02040c + m02554c + m01089c 0.00 1000.00 0.00
RE1807C m00756c + m02040c + m02554c <=> m00758c + 2 m02039c + m02555c -1000.00 1000.00 0.00
@@ -8891,8 +8890,7 @@ RE1809C m02039c + m02555c + m02630c + m01089c -> m02040c + m02554c + m01085c
RE1810M m01095m + 2 m02554m <=> 2 m02039m + 2 m02555m + m01182m -1000.00 1000.00 0.00
RE1811C m02039c + m02555c + m02630c + m01089c -> m02040c + m02554c + m01086c 0.00 1000.00 0.00
RE1812C m02039c + m02555c + m02630c + m01089c -> m02040c + m02554c + m01088c 0.00 1000.00 0.00
-RE1826C m01095c + m02039c + m02555c + m02630c -> m02040c + m02554c + CE0233_c 0.00 1000.00 0.00
-RE1826M m01095m + m02039m + m02555m + m02630m -> m02040m + m02554m + CE0233_m ENSG00000135929 0.00 1000.00 0.00
+RE1826C m01095c + m02039c + m02555c + m02630c -> m02040c + m02554c + m01094c 0.00 1000.00 0.00
RE1827C m00623c + m02554c <=> m02039c + m02555c + m00763c -1000.00 1000.00 0.00
RE1828C m02039c + m02555c + m02630c + m00764c -> m02040c + m02554c + m00761c 0.00 1000.00 0.00
RE1829C m02554c + m00761c <=> m02039c + m02555c + m01180c -1000.00 1000.00 0.00
@@ -8915,8 +8913,6 @@ RE2078M m02786m <=> m02040m + m02777m -1000.00 1000.00 0.00
RE2146C m03109c + CE2953_c -> m02826c + m03106c ENSG00000241635 0.00 1000.00 0.00
RE2152C m02040c + 2 m02552c + CE1162_c <=> 3 m02039c + 2 m02553c + CE2955_c -1000.00 1000.00 0.00
RE2155R m02039r + m02553r + m02630r + m01314r -> m02040r + m02552r + m00604r ENSG00000231852 0.00 1000.00 0.00
-RE2202C m02624c <=> CE5775_c -1000.00 1000.00 0.00
-RE2203C m02624c <=> CE5776_c -1000.00 1000.00 0.00
RE2221C m02039c + m02553c + m02630c + CE1297_c -> m02040c + m02552c + CE1294_c 0.00 1000.00 0.00
RE2221M m02039m + m02553m + m02630m + CE1297_m -> m02040m + m02552m + CE1294_m ENSG00000135929 0.00 1000.00 0.00
RE2250C CE5932_c <=> CE5013_c -1000.00 1000.00 0.00
@@ -9236,7 +9232,6 @@ EX_HC02194[e] m03129s <=> -1000.00 1000.00 0.00
EX_HC02197[e] m02951s <=> -1000.00 1000.00 0.00
EX_HC02198[e] m02952s <=> -1000.00 1000.00 0.00
EX_HC02187[e] m02839s <=> -1000.00 1000.00 0.00
-EX_HC02180[e] m02995s <=> -1000.00 1000.00 0.00
EX_HC02202[e] m02776s <=> -1000.00 1000.00 0.00
EX_HC02203[e] m02777s <=> -1000.00 1000.00 0.00
EX_HC02204[e] m02778s <=> -1000.00 1000.00 0.00
@@ -9258,14 +9253,14 @@ EX_CE1940[e] m02922s <=> -1000.00 1000.00 0.00
EX_CE1943[e] m02920s <=> -1000.00 1000.00 0.00
EX_CE2011[e] m02158s <=> -1000.00 1000.00 0.00
EX_CE1939[e] m02921s <=> -1000.00 1000.00 0.00
-EX_maltpt[e] maltpt_s <=> -1000.00 1000.00 0.00
+EX_maltpt[e] m02449s <=> -1000.00 1000.00 0.00
EX_CE2915[e] m01387s <=> -1000.00 1000.00 0.00
EX_CE4722[e] m01386s <=> -1000.00 1000.00 0.00
EX_CE2916[e] m02563s <=> -1000.00 1000.00 0.00
EX_CE4723[e] m02562s <=> -1000.00 1000.00 0.00
EX_CE2917[e] m01348s <=> -1000.00 1000.00 0.00
EX_CE4724[e] m01347s <=> -1000.00 1000.00 0.00
-EX_malthp[e] malthp_s <=> -1000.00 1000.00 0.00
+EX_malthp[e] m02446s <=> -1000.00 1000.00 0.00
EX_CE2838[e] m02448s <=> -1000.00 1000.00 0.00
EX_CE1950[e] CE1950_s <=> -1000.00 1000.00 0.00
EX_cynt[e] cynt_s <=> -1000.00 1000.00 0.00
@@ -9627,8 +9622,8 @@ TETDECE1CRNe tetdece1crn_c -> tetdece1crn_s 0.00 1000.00 0.00
TIGCRNe c51crn_c -> c51crn_s 0.00 1000.00 0.00
34DHPHELAT1tc m02354s + m02360c -> m02354c + m02360s ENSG00000103257 and ENSG00000168003 0.00 1000.00 0.00
4OHPROIMINOtc m01442s + 2 m02519s + m03037s -> m01442c + 2 m02519c + m03037c ENSG00000147003 and ENSG00000163817 0.00 1000.00 0.00
-ALAALACNc m02040c + alaala_c <=> 2 m01307c ENSG00000133313 or ENSG00000150656 -1000.00 1000.00 0.00
-ALAALAPEPT1tc m02039s + alaala_s -> m02039c + alaala_c ENSG00000088386 0.00 1000.00 0.00
+ALAALACNc m02040c + m03164c <=> 2 m01307c ENSG00000133313 or ENSG00000150656 -1000.00 1000.00 0.00
+ALAALAPEPT1tc m02039s + m03164s -> m02039c + m03164c ENSG00000088386 0.00 1000.00 0.00
ALAyLATthc m01307s + m01365c + m02039s -> m01307c + m01365s + m02039c ( ENSG00000103064 and ENSG00000168003 ) or ( ENSG00000155465 and ENSG00000168003 ) 0.00 1000.00 0.00
ASCBSVCTtc m01368s + m01371c + m02040c + 2 m02519s -> m01285c + m01368c + m02039c + 2 m02519c + m02751c ENSG00000089057 or ENSG00000170482 0.00 1000.00 0.00
ASNATB0tc m01369s + m01442s + 2 m02519s -> m01369c + m01442c + 2 m02519c ENSG00000268104 0.00 1000.00 0.00
@@ -9719,7 +9714,7 @@ DTMPKm m01371m + m01752m -> m01285m + m01747m ENSG00000168393 0.00 1000.00
DTTPtm m01753c -> m01753m 0.00 1000.00 0.00
EX_4hpro[e] m03037s <=> -1000.00 1000.00 0.00
EX_adpcbl[e] m01600s <=> -1000.00 1000.00 0.00
-EX_alaala[e] alaala_s <=> -1000.00 1000.00 0.00
+EX_alaala[e] m03164s <=> -1000.00 1000.00 0.00
EX_bglc[e] bglc_s <=> -1000.00 1000.00 0.00
EX_carn[e] m01423s <=> -1000.00 1000.00 0.00
EX_dchac[e] m00745s <=> -1000.00 1000.00 0.00
@@ -9942,7 +9937,6 @@ ADPOHc m00670c + m02039c + m02553c <=> m02552c + adpoh_c -1000.00 1000.00 0
PHLAC m02552c + phlac_c <=> m02039c + m02553c + m02725c -1000.00 1000.00 0.00
AND19ONEc m00971c + m02039c + m02555c + m02630c -> m02040c + m02554c + and19one_c ENSG00000100197 0.00 1000.00 0.00
DESAT14_9 m02039c + m02495c + m02553c + m02630c -> 2 m02040c + m02552c + ttdceacoa_c ENSG00000134824 0.00 1000.00 0.00
-21HPRGNLONE m02039c + m02555c + m02630c + m02763c -> m02040c + m02554c + 21hprgnlone_c ENSG00000231852 0.00 1000.00 0.00
3MHISc m02125c + m02877c <=> m02039c + m02871c + 3mhis_c -1000.00 1000.00 0.00
HMCRNc m01420c + m02426c <=> m02039c + m02751c + hmcr_c -1000.00 1000.00 0.00
PHACGLYc m01986c + m02721c -> m01597c + m02039c + phacgly_c 0.00 1000.00 0.00
@@ -9957,7 +9951,6 @@ HXCOAc m02040c + m02122c <=> m01597c + m02039c + hxa_c -1000.00 1000.00 0.0
TETDECA511ACc m02040c + tetdec2coa_c -> m01597c + m02039c + tetdeca511ac_c 0.00 1000.00 0.00
GPDDACHOL m02040c + m02912c -> m01513c + m02039c + glyc2p_c ENSG00000125772 0.00 1000.00 0.00
ACLYSHYc m02040c + aclys_c <=> m01252c + m02426c -1000.00 1000.00 0.00
-HMCARNc m00970c + m01371c + m02125c <=> m01334c + m02039c + m02759c + hmcarn_c -1000.00 1000.00 0.00
METTRANSc m02471c + m02819c <=> m01307c + 4mtob_c -1000.00 1000.00 0.00
METDECARc m02039c + 4mtob_c -> m01596c + 3mtp_c 0.00 1000.00 0.00
3MTPte 3mtp_c -> 3mtp_s 0.00 1000.00 0.00
@@ -9970,8 +9963,8 @@ TTDCRNNAt m02519c + m02974c <=> m02519s + m02974s -1000.00 1000.00 0.00
12HPETATP m00309c + m01371c + m02040c -> m00309s + m01285c + m02039c + m02751c 0.00 1000.00 0.00
15HPETATP m00380c + m01371c + m02040c -> m01285c + m02039c + m02751c + m00380s 0.00 1000.00 0.00
15KPROSTGF2t m02403s + 15kprostgf2_c <=> m02403c + 15kprostgf2_s -1000.00 1000.00 0.00
-21HPRGNLONEt1 m01371c + m02040c + 21hprgnlone_c -> m01285c + m02039c + m02751c + 21hprgnlone_s 0.00 1000.00 0.00
-21HPRGNLONEt2 21hprgnlone_c <=> 21hprgnlone_s -1000.00 1000.00 0.00
+21HPRGNLONEt1 m00605c + m01371c + m02040c -> m01285c + m02039c + m02751c + m00605s 0.00 1000.00 0.00
+21HPRGNLONEt2 m00605c <=> m00605s -1000.00 1000.00 0.00
2OXOADPt m00670c + m01306s <=> m01306c + m00670s -1000.00 1000.00 0.00
34HPLte m01004c + m02039c <=> m02039s + m01004s -1000.00 1000.00 0.00
3HMPtd m00784c <=> m00784s -1000.00 1000.00 0.00
@@ -10078,7 +10071,7 @@ ELAIDCRNtd m00126c <=> m00126s -1000.00 1000.00 0.00
EX_12HPET[e] m00309s <=> -1000.00 1000.00 0.00
EX_15HPET[e] m00380s <=> -1000.00 1000.00 0.00
EX_15kprostgf2[e] 15kprostgf2_s <=> -1000.00 1000.00 0.00
-EX_21hprgnlone[e] 21hprgnlone_s <=> -1000.00 1000.00 0.00
+EX_21hprgnlone[e] m00605s <=> -1000.00 1000.00 0.00
EX_2oxoadp[e] m00670s <=> -1000.00 1000.00 0.00
EX_34hpl[e] m01004s <=> -1000.00 1000.00 0.00
EX_3hmp[e] m00784s <=> -1000.00 1000.00 0.00
@@ -10144,7 +10137,7 @@ EX_hepdeceth[e] hepdeceth_s <=> -1000.00 1000.00 0.00
EX_hexdeceeth[e] hexdeceeth_s <=> -1000.00 1000.00 0.00
EX_hexdiac[e] hexdiac_s <=> -1000.00 1000.00 0.00
EX_hgentis[e] m02135s <=> -1000.00 1000.00 0.00
-EX_hmcarn[e] hmcarn_s <=> -1000.00 1000.00 0.00
+EX_hmcarn[e] m02132s <=> -1000.00 1000.00 0.00
EX_hmcr[e] hmcr_s <=> -1000.00 1000.00 0.00
EX_hxcoa[e] m02122s <=> -1000.00 1000.00 0.00
EX_leuktrB4wcooh[e] m00585s <=> -1000.00 1000.00 0.00
@@ -10242,7 +10235,7 @@ EX_thrnt[e] m02992s <=> -1000.00 1000.00 0.00
EX_tmlys[e] m02517s <=> -1000.00 1000.00 0.00
EX_trideceth[e] trideceth_s <=> -1000.00 1000.00 0.00
EX_ttdcrn[e] m02974s <=> -1000.00 1000.00 0.00
-EX_txb2[e] txb2_s <=> -1000.00 1000.00 0.00
+EX_txb2[e] m02995s <=> -1000.00 1000.00 0.00
EX_urcan[e] m03124s <=> -1000.00 1000.00 0.00
EX_wharachd[e] m00270s <=> -1000.00 1000.00 0.00
EX_xolest181_hs[e] xolest181_hs_s <=> -1000.00 1000.00 0.00
@@ -10267,7 +10260,7 @@ HC02149td m02657c <=> m02657s -1000.00 1000.00 0.00
HEXDIACATP m01371c + m02040c + hexdiac_c -> m01285c + m02039c + m02751c + hexdiac_s 0.00 1000.00 0.00
HEXDIACtd hexdiac_c <=> hexdiac_s -1000.00 1000.00 0.00
HGENTISt m02135c <=> m02135s -1000.00 1000.00 0.00
-HMCARNt m01413c + m02039s + hmcarn_c <=> m01413s + m02039c + hmcarn_s -1000.00 1000.00 0.00
+HMCARNt m01413c + m02039s + m02132c <=> m01413s + m02039c + m02132s -1000.00 1000.00 0.00
HMCRNt hmcr_c <=> hmcr_s -1000.00 1000.00 0.00
HPPPNte m02039s + 3hpppn_s <=> m02039c + 3hpppn_c -1000.00 1000.00 0.00
HXCOAm m02040m + m02122m -> m01597m + m02039m + hxa_m 0.00 1000.00 0.00
@@ -10302,8 +10295,8 @@ TETDECA511ACtd tetdeca511ac_c <=> tetdeca511ac_s -1000.00 1000.00 0.00
THRACm m01261m + m02993m -> m01597m + m02039m + acthr_L_m 0.00 1000.00 0.00
THRNTt m01371c + m02040c + m02992c -> m01285c + m02039c + m02751c + m02992s 0.00 1000.00 0.00
TMLYStd m02517c <=> m02517s -1000.00 1000.00 0.00
-TXB2c m02040c + m02994c <=> txb2_c -1000.00 1000.00 0.00
-TXB2t m01371c + m02040c + txb2_c -> m01285c + m02039c + m02751c + txb2_s 0.00 1000.00 0.00
+TXB2c m02040c + m02994c <=> m02995c -1000.00 1000.00 0.00
+TXB2t m01371c + m02040c + m02995c -> m01285c + m02039c + m02751c + m02995s 0.00 1000.00 0.00
URCANt m03124c <=> m03124s -1000.00 1000.00 0.00
WHARACHDt m00270c + m01371c + m02040c -> m01285c + m02039c + m02751c + m00270s 0.00 1000.00 0.00
WHARACHDtd m00270c <=> m00270s -1000.00 1000.00 0.00
@@ -10355,8 +10348,7 @@ XOL27OHtmc m00623m <=> m00623c -1000.00 1000.00 0.00
ALPA_HStc alpa_hs_p <=> alpa_hs_c -1000.00 1000.00 0.00
BZCOAFm m01371m + m01597m + m01380m -> m01334m + m02759m + bzcoa_m 0.00 1000.00 0.00
BGLYFm m01986m + bzcoa_m -> m01597m + m02039m + m02123m 0.00 1000.00 0.00
-GLYNATm m01986m + m02721m <=> m01597m + m02039m + pheacgly_m ENSG00000149124 -1000.00 1000.00 0.00
-PHEACGLYsec pheacgly_c -> pheacgly_s 0.00 1000.00 0.00
+GLYNATm m01986m + m02721m <=> m01597m + m02039m + m02723m ENSG00000149124 -1000.00 1000.00 0.00
PCSF m02682c + pcresol_c -> m02681c + pcs_c ENSG00000196502 0.00 1000.00 0.00
INDOXYLF m02040c + m02554c + indole_c -> 2 m02039c + m02555c + indoxyl_c ENSG00000130649 0.00 1000.00 0.00
INDSF m02682c + indoxyl_c -> m02681c + inds_c ENSG00000196502 0.00 1000.00 0.00
@@ -10372,7 +10364,6 @@ PCSup pcs_s -> pcs_c 0.00 1000.00 0.00
EX_3hcinnm[e] 3hcinnm_s <=> -1000.00 1000.00 0.00
EX_3hppa[e] 3hppa_s <=> -1000.00 1000.00 0.00
EX_bgly[e] m02123s <=> -1000.00 1000.00 0.00
-EX_pheacgly[e] pheacgly_s <=> -1000.00 1000.00 0.00
EX_bz[e] m01380s <=> -1000.00 1000.00 0.00
EX_pcresol[e] pcresol_s <=> -1000.00 1000.00 0.00
EX_pcs[e] pcs_s <=> -1000.00 1000.00 0.00
@@ -10382,7 +10373,7 @@ MEPIt m02407s <=> m02407c -1000.00 1000.00 0.00
TREt m03039s <=> m03039c -1000.00 1000.00 0.00
C05300t m00400c <=> m00400s -1000.00 1000.00 0.00
RETINALt m02832c <=> m02832s -1000.00 1000.00 0.00
-MALTTTRt maltttr_s <=> maltttr_c -1000.00 1000.00 0.00
+MALTTTRt m02451s <=> m02451c -1000.00 1000.00 0.00
LEULEUt leuleu_c <=> leuleu_s -1000.00 1000.00 0.00
GLYPROt glypro_c <=> glypro_s -1000.00 1000.00 0.00
PROGLyt progly_c <=> progly_s -1000.00 1000.00 0.00
@@ -10391,7 +10382,7 @@ THBPTt m02978c <=> m02978s -1000.00 1000.00 0.00
EX_normete_L[e] m02622s <=> -1000.00 1000.00 0.00
EX_C05300[e] m00400s <=> -1000.00 1000.00 0.00
EX_retinal[e] m02832s <=> -1000.00 1000.00 0.00
-EX_maltttr[e] maltttr_s <=> -1000.00 1000.00 0.00
+EX_maltttr[e] m02451s <=> -1000.00 1000.00 0.00
EX_progly[e] progly_s <=> -1000.00 1000.00 0.00
EX_dhbpt[e] m01698s <=> -1000.00 1000.00 0.00
EX_thbpt[e] m02978s <=> -1000.00 1000.00 0.00
@@ -10885,7 +10876,7 @@ ALAASNLEUr 2 m02040c + alaasnleu_c <=> m01307c + m01369c + m02360c -1000.00 1
ALAGLYLYSr 2 m02040c + alaglylys_c <=> m01307c + m01986c + m02426c -1000.00 1000.00 0.00
ALAHISALAr 2 m02040c + alahisala_c <=> 2 m01307c + m02125c -1000.00 1000.00 0.00
ALALYSTHRr 2 m02040c + alalysthr_c <=> m01307c + m02426c + m02993c -1000.00 1000.00 0.00
-ARGALAALAr m01365c + alaala_c <=> m02040c + argalaala_c -1000.00 1000.00 0.00
+ARGALAALAr m01365c + m03164c <=> m02040c + argalaala_c -1000.00 1000.00 0.00
ARGALAPHEr 2 m02040c + argalaphe_c <=> m01307c + m01365c + m02724c -1000.00 1000.00 0.00
ARGALATHRr 2 m02040c + argalathr_c <=> m01307c + m01365c + m02993c -1000.00 1000.00 0.00
ARGARGr m02040c + argarg_c <=> 2 m01365c -1000.00 1000.00 0.00
@@ -11187,7 +11178,7 @@ XOLEST205tl xolest205_hs_c <=> xolest205_hs_l -1000.00 1000.00 0.00
XOLEST204tl xolest204_hs_c <=> xolest204_hs_l -1000.00 1000.00 0.00
XOLEST226tl xolest226_hs_c <=> xolest226_hs_l -1000.00 1000.00 0.00
BGLYtm m02123m <=> m02123c -1000.00 1000.00 0.00
-PHEACGLYtm pheacgly_m <=> pheacgly_c -1000.00 1000.00 0.00
+PHEACGLYtm m02723m <=> m02723c -1000.00 1000.00 0.00
HXAt1 hxa_m <=> hxa_c -1000.00 1000.00 0.00
HXAt2 hxa_p <=> hxa_c -1000.00 1000.00 0.00
HXAt3 hxa_c <=> hxa_s -1000.00 1000.00 0.00
@@ -11210,8 +11201,6 @@ ACNAMt2 m02039s + m02543s -> m02039c + m02543c 0.00 1000.00 0.00
BANDMT m02877c + band_c <=> m02039c + m02871c + bandmt_c -1000.00 1000.00 0.00
C181CPT2rbc m01597c + m02639c <=> m02348c + m02647c -1000.00 1000.00 0.00
CA2t m01413s <=> m01413c -1000.00 1000.00 0.00
-DKMPPD2 m02630c + dhmtp_c -> m01016c + m01833c + m02039c 0.00 1000.00 0.00
-DKMPPD3 m00572c + m02040c -> m02039c + m02751c + dhmtp_c 0.00 1000.00 0.00
GTHOXti2 m01371c + m02027c + m02040c -> m01285c + m02027s + m02039c + m02751c 0.00 1000.00 0.00
HCYSte m02133s <=> m02133c -1000.00 1000.00 0.00
NORMETEVESSte 2 m01371c + 2 m02040c + 3 m02622c -> 2 m01285c + 2 m02039c + 2 m02751c + 3 m02622s 0.00 1000.00 0.00
@@ -11325,7 +11314,7 @@ CITL m01587c -> m01252c + m02633c ENSG00000125246 0.00 1000.00 0.00
EX_galt[e] m01909s <=> -1000.00 1000.00 0.00
EX_glcr[e] m01681s <=> -1000.00 1000.00 0.00
EX_glcur[e] m01973s <=> -1000.00 1000.00 0.00
-EX_malthx[e] malthx_s <=> -1000.00 1000.00 0.00
+EX_malthx[e] m02447s <=> -1000.00 1000.00 0.00
EX_ptrc[e] m02812s <=> -1000.00 1000.00 0.00
EX_spmd[e] m02923s <=> -1000.00 1000.00 0.00
EX_xan[e] m03148s <=> -1000.00 1000.00 0.00
@@ -11924,7 +11913,7 @@ NADPQNOXR m02039c + m02555c + 23dh1i56dio_c -> m02361c + m02554c ENSG000001810
NADQNOXR m02039c + m02553c + 23dh1i56dio_c -> m02361c + m02552c ENSG00000181019 0.00 1000.00 0.00
DACT 23dh1i56dio_c <=> m01739c -1000.00 1000.00 0.00
DACGST m02026c + 23dh1i56dio_c <=> 4glu56dihdind_c ENSG00000213366 -1000.00 1000.00 0.00
-TYRDHINDOX 2 m01739c + m02630c -> 2 m02040c + 2 ind56qn_c ENSG00000077498 0.00 1000.00 0.00
+TYRDHINDOX 2 m01739c + m02630c -> 2 m02040c + 2 m03163c ENSG00000077498 0.00 1000.00 0.00
4GLU56DIHDINDt m01371c + m02040c + 4glu56dihdind_c -> m01285c + m02039c + m02751c + 4glu56dihdind_s 0.00 1000.00 0.00
EX_4glu56dihdind[e] 4glu56dihdind_s <=> -1000.00 1000.00 0.00
5CYSDOPAt 5cysdopa_c <=> 5cysdopa_s -1000.00 1000.00 0.00
@@ -11981,14 +11970,13 @@ NEU38n m02040n + m01941n -> m02543n + gm1_hs_n ENSG00000162139 or ENSG00000204
NEU39e m02040s + m02010s -> m02543s + m01904s ENSG00000162139 0.00 1000.00 0.00
SMS21e m02684s + m01430s -> m02908s + m00235s ENSG00000164023 0.00 1000.00 0.00
SMSn m01430n + m02684n -> m02908n + m00235n 0.00 1000.00 0.00
-SPHK11 m01371c + phsphings_c -> m01285c + m02039c + phsph1p_c ENSG00000176170 0.00 1000.00 0.00
+SPHK11 m01371c + m02749c -> m01285c + m02039c + phsph1p_c ENSG00000176170 0.00 1000.00 0.00
SPHK21n m01371n + m02929n -> m01285n + m02039n + m02930n ENSG00000063176 0.00 1000.00 0.00
SPHK22n m01371n + m02927n -> m01285n + m02039n + m02928n ENSG00000063176 0.00 1000.00 0.00
SPHMYLNte m02908g -> m02908s 0.00 1000.00 0.00
SPHMYLNtl2 m01371l + m02040l + m02908s -> m01285l + m02039l + m02751l + m02908l 0.00 1000.00 0.00
SPMD3n m02040n + m02908n -> m02039n + m01430n + m02738n ENSG00000103056 0.00 1000.00 0.00
ST8SIA13e m02015s + m01592s -> m01590s + m02039s + m01947s ENSG00000113532 0.00 1000.00 0.00
-RE3477C1 m02552c + txb2_c -> m00293c + m02039c + m02553c 0.00 1000.00 0.00
NO2te m02039s + m02588s <=> m02039c + m02588c -1000.00 1000.00 0.00
NH4tr m02579c <=> m02579r -1000.00 1000.00 0.00
WHTSTSTERONEtr m00432c <=> m00432r -1000.00 1000.00 0.00
@@ -12010,8 +11998,8 @@ EX_gd2_hs[e] m01946s <=> -1000.00 1000.00 0.00
EX_gd1a_hs[e] m01941s <=> -1000.00 1000.00 0.00
DHCRMtg m01699c -> m01699g 0.00 1000.00 0.00
DHCRMter m01699c -> m01699r 0.00 1000.00 0.00
-PHSPHINGStg phsphings_g -> phsphings_c 0.00 1000.00 0.00
-PHSPHINGStr phsphings_r -> phsphings_c 0.00 1000.00 0.00
+PHSPHINGStg m02749g -> m02749c 0.00 1000.00 0.00
+PHSPHINGStr m02749r -> m02749c 0.00 1000.00 0.00
PHSGPL11c phsph1p_c -> m01798c + hhxdcal_c 0.00 1000.00 0.00
LCYSTtm m02350c -> m02350m 0.00 1000.00 0.00
34DHPEt 34dhpe_s <=> 34dhpe_c -1000.00 1000.00 0.00
@@ -12590,7 +12578,6 @@ EX_mdzglc[e] mdzglc_s <=> -1000.00 1000.00 0.00
EX_meracmp[e] meracmp_s <=> -1000.00 1000.00 0.00
EX_mhglz[e] mhglz_s <=> -1000.00 1000.00 0.00
EX_ndersv[e] ndersv_s <=> -1000.00 1000.00 0.00
-EX_nfd[e] nfd_s <=> -1000.00 1000.00 0.00
EX_nfdac[e] nfdac_s <=> -1000.00 1000.00 0.00
EX_nfdlac[e] nfdlac_s <=> -1000.00 1000.00 0.00
EX_nfdnpy[e] nfdnpy_s <=> -1000.00 1000.00 0.00
@@ -12703,8 +12690,7 @@ NFDLAChc m02039c + nfdoh_c <=> m02040c + nfdlac_c -1000.00 1000.00 0.00
NFDLACtep nfdlac_c <=> nfdlac_s -1000.00 1000.00 0.00
NFDNPYtep nfdnpy_c <=> nfdnpy_s -1000.00 1000.00 0.00
NFDOHtep nfdoh_c <=> nfdoh_s -1000.00 1000.00 0.00
-NFDOXDhc m02554c + nfd_c -> m02039c + m02555c + nfdnpy_c 0.00 1000.00 0.00
-NFDtd nfd_s <=> nfd_c -1000.00 1000.00 0.00
+NFDOXDhc m02554c + m02587c -> m02039c + m02555c + nfdnpy_c 0.00 1000.00 0.00
OXYP1CONJ oxyp_c + udprib_c -> m02039c + m03106c + oxy1rb_c 0.00 1000.00 0.00
OXYP2CONJ oxyp_c + udprib_c -> m02039c + m03106c + oxy7rb_c 0.00 1000.00 0.00
OXYPR1tehv oxy1rb_c <=> oxy1rb_s -1000.00 1000.00 0.00
@@ -12970,10 +12956,6 @@ EX_M03153[e] m03153s <=> -1000.00 1000.00 0.00
EX_M01268[e] m01268s <=> -1000.00 1000.00 0.00
EX_HC02080[e] m01395s <=> -1000.00 1000.00 0.00
EX_h2co3[e] m01421s <=> -1000.00 1000.00 0.00
-EX_M02446[e] m02446s <=> -1000.00 1000.00 0.00
-EX_M02447[e] m02447s <=> -1000.00 1000.00 0.00
-EX_M02449[e] m02449s <=> -1000.00 1000.00 0.00
-EX_M02451[e] m02451s <=> -1000.00 1000.00 0.00
EX_M02837[e] m02837s <=> -1000.00 1000.00 0.00
EX_M02382[e] m02382s <=> -1000.00 1000.00 0.00
EX_M02035[e] m02035s <=> -1000.00 1000.00 0.00
@@ -12998,7 +12980,6 @@ HMR_10028 chylo_hs_s <=> -1000.00 1000.00 0.00
HMR_10029 m10001s <=> -1000.00 1000.00 0.00
HMR_10030 m10002s <=> -1000.00 1000.00 0.00
HMR_10031 m10003s <=> -1000.00 1000.00 0.00
-HMR_10032 m10000s <=> -1000.00 1000.00 0.00
HMR_10033 m10005c <=> 0.0004 m00003c + 0.0004 m00008c + 0.0004 m00010c + 0.0004 m00017c + 0.0004 m00019c + 0.0004 m00021c + 0.0038 m00094c + 0.0004 m00104c + 0.0004 m00111c + 0.0004 m00114c + 0.0004 m00115c + 0.0004 m00117c + 0.0004 m00128c + 0.0004 m00132c + 0.0004 m00135c + 0.0004 m00260c + 0.0004 m00265c + 0.0004 m00315c + 0.0004 m00341c + 0.0004 m01197c + 0.0004 m01207c + 0.0004 m01235c + 0.0004 m01238c + 0.0014 m01291c + 0.1083 m01362c + 0.0004 m01373c + 0.0004 m01432c + 0.0004 m01582c + 0.0004 m01583c + 0.0004 m01584c + 0.025 m01585c + 0.0278 m01689c + 0.0215 m01696c + 0.0059 m01741c + 0.0004 m01771c + 0.0004 m01778c + 0.0116 m01784c + 0.0029 m01932c + 0.0004 m02053c + 0.0004 m02344c + 0.0004 m02385c + 0.1915 m02387c + 0.0084 m02389c + 0.0004 m02456c + 0.0004 m02457c + 0.0133 m02494c + 0.0004 m02564c + 0.0004 m02613c + 0.1545 m02646c + 0.0115 m02648c + 0.222 m02674c + 0.0219 m02675c + 0.0004 m02690c + 0.0004 m02745c + 0.1498 m02938c + 0.0025 m02939c + 0.0004 m03045c + 0.0004 m03051c + 0.0004 m03153c -1000.00 1000.00 0.00
HMR_10034 m10005r <=> 0.0004 m00003r + 0.0004 m00008r + 0.0004 m00010r + 0.0004 m00017r + 0.0004 m00019r + 0.0004 m00021r + 0.0038 m00094r + 0.0004 m00104r + 0.0004 m00111r + 0.0004 m00114r + 0.0004 m00115r + 0.0004 m00117r + 0.0004 m00128r + 0.0004 m00132r + 0.0004 m00135r + 0.0004 m00260r + 0.0004 m00265r + 0.0004 m00315r + 0.0004 m00341r + 0.0004 m01197r + 0.0004 m01207r + 0.0004 m01235r + 0.0004 m01238r + 0.0014 m01291r + 0.1083 m01362r + 0.0004 m01373r + 0.0004 m01432r + 0.0004 m01582r + 0.0004 m01583r + 0.0004 m01584r + 0.025 m01585r + 0.0278 m01689r + 0.0215 m01696r + 0.0059 m01741r + 0.0004 m01771r + 0.0004 m01778r + 0.0116 m01784r + 0.0029 m01932r + 0.0004 m02053r + 0.0004 m02344r + 0.0004 m02385r + 0.1915 m02387r + 0.0084 m02389r + 0.0004 m02456r + 0.0004 m02457r + 0.0133 m02494r + 0.0004 m02564r + 0.0004 m02613r + 0.1545 m02646r + 0.0115 m02648r + 0.222 m02674r + 0.0219 m02675r + 0.0004 m02690r + 0.0004 m02745r + 0.1498 m02938r + 0.0025 m02939r + 0.0004 m03045r + 0.0004 m03051r + 0.0004 m03153r -1000.00 1000.00 0.00
HMR_10035 m10006c <=> 0.0004 m00436c + 0.0004 m00437c + 0.0004 m00438c + 0.0004 m00439c + 0.0004 m00440c + 0.0004 m00441c + 0.0004 m00442c + 0.0004 m00443c + 0.0004 m00444c + 0.0004 m00445c + 0.0004 m00446c + 0.0004 m00447c + 0.0004 m00448c + 0.0004 m00449c + 0.0278 m00450c + 0.0038 m00451c + 0.0116 m00452c + 0.0004 m00453c + 0.0004 m00454c + 0.0004 m00455c + 0.0004 m00456c + 0.0025 m00457c + 0.0004 m00458c + 0.0059 m00459c + 0.0014 m00460c + 0.0004 m00461c + 0.0004 m00462c + 0.0004 m00463c + 0.0115 m00464c + 0.0004 m00465c + 0.0004 m00466c + 0.0004 m00467c + 0.0004 m00468c + 0.0004 m00469c + 0.0004 m00470c + 0.0004 m00471c + 0.1083 m00472c + 0.025 m00474c + 0.0215 m00476c + 0.0004 m00477c + 0.0004 m00478c + 0.0029 m00479c + 0.0004 m00480c + 0.0004 m00481c + 0.0004 m00482c + 0.0004 m00483c + 0.0004 m00484c + 0.1915 m00491c + 0.0084 m00492c + 0.0133 m00493c + 0.0004 m00494c + 0.1545 m00495c + 0.222 m00496c + 0.0219 m00497c + 0.0004 m00498c + 0.1498 m00499c + 0.0004 m00500c + 0.0004 m00501c + 0.0004 m00502c -1000.00 1000.00 0.00
diff --git a/model/Human-GEM.xlsx b/model/Human-GEM.xlsx
index 78bab1b3..b8f02ab1 100644
Binary files a/model/Human-GEM.xlsx and b/model/Human-GEM.xlsx differ
diff --git a/model/Human-GEM.xml b/model/Human-GEM.xml
index a3197ba0..6cb4347b 100644
--- a/model/Human-GEM.xml
+++ b/model/Human-GEM.xml
@@ -13,10 +13,10 @@
- 2020-10-17T18:13:32Z
+ 2021-01-25T12:41:39Z
- 2020-10-17T18:13:32Z
+ 2021-01-25T12:41:39Z
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