diff --git a/code/modelCuration/reportPeroxGenesFromBetaoxidationGPRsInMito.py b/code/modelCuration/reportPeroxGenesFromBetaoxidationGPRsInMito.py new file mode 100644 index 00000000..20c47843 --- /dev/null +++ b/code/modelCuration/reportPeroxGenesFromBetaoxidationGPRsInMito.py @@ -0,0 +1,26 @@ +# 1. read gene compartment from genes.tsv and load model +# 2. get the reactions in fatty acid oxidation subsystem and mitochondria compartment +# 3. go through the reactions and check the compartment of each genes in the GPR +# 4. report the genes that are only expressed in peroxisome +import csv +import cobra +import pandas as pd + +# load genes.tsv and read info into a dict for genes and their compartments +with open("../../model/genes.tsv", 'r') as file: + reader = csv.reader(file, delimiter='\t') + geneCompDict = {row[0]: row[8] for row in reader} + +# load model +model = cobra.io.load_yaml_model('../../model/Human-GEM.yml') + +# collect reactions from "Fatty acid oxidation" subsystem and in [m] compartment +subsys = 'Fatty acid oxidation' +targetComp = {'m'} +for r in model.reactions: + if subsys in r.subsystem and targetComp == r.compartments: + # go through collected reactions find genes that exist only in peroxisome + for g in r.genes: + if geneCompDict[g.id] == 'Peroxisome': + print(f'{r.id} | {g.id} | {r.build_reaction_string(True)} | {r.gene_reaction_rule} | {r.gene_name_reaction_rule}') + diff --git a/data/deprecatedIdentifiers/deprecatedMetabolites.tsv b/data/deprecatedIdentifiers/deprecatedMetabolites.tsv index 6f646a4c..d935bba1 100644 --- a/data/deprecatedIdentifiers/deprecatedMetabolites.tsv +++ b/data/deprecatedIdentifiers/deprecatedMetabolites.tsv @@ -2258,3 +2258,8 @@ mets metsNoComp metBiGGID metKEGGID metHMDBID metChEBIID metPubChemID metLipidMa "MAM03684m" "MAM03684" "hxa" "" "" "" "" "" "" "" "hxa" "MNXM1653" "" "hxa_m" "MAM03684e" "MAM03684" "hxa" "" "" "" "" "" "" "" "hxa" "MNXM1653" "" "hxa_s" "MAM03684x" "MAM03684" "hxa" "" "" "" "" "" "" "" "hxa" "MNXM1653" "" "hxa_p" +"MAM02986n" "MAM02986" "tcynt" "C01755" "HMDB0001453" "CHEBI:18022" "9322" "" "" "" "tcynt" "MNXM762" "" "m02986n" +"MAM02158m" "MAM02158" "" "" "" "" "124985" "" "CE2011" "" "CE2011" "MNXM57006" "" "m02158m" +"MAM02158n" "MAM02158" "" "" "" "" "124985" "" "CE2011" "" "CE2011" "MNXM57006" "" "m02158n" +"MAM00678c" "MAM00678" "" "" "" "" "22833562" "" "CE2435" "" "dec24dicoa" "MNXM1601" "" "m00678c" +"MAM03035c" "MAM03035" "" "" "" "" "16019966" "" "CE5121" "" "dece3coa" "MNXM90096" "" "m03035c" diff --git a/data/deprecatedIdentifiers/deprecatedReactions.tsv b/data/deprecatedIdentifiers/deprecatedReactions.tsv index 8c912b7b..c21654f1 100644 --- a/data/deprecatedIdentifiers/deprecatedReactions.tsv +++ b/data/deprecatedIdentifiers/deprecatedReactions.tsv @@ -262,7 +262,24 @@ rxns rxnKEGGID rxnBiGGID rxnEHMNID rxnHepatoNET1ID rxnREACTOMEID rxnRecon3DID rx "MAR04239" "R01933" "2OXOADOXm" "R01933M" "r0448" "" "2OXOADOXm" "MNXR94818" "HMR_4239" "RCR11332" "" 0 "RHEA:30796" "RHEA:30795" "HMR_4239" "MAR04940" "" "" "" "r0885" "" "r0885" "MNXR105402" "HMR_4940" "RCR20265" "2.A.29.2.7" 0 "" "" "HMR_4940" "MAR06391" "" "" "" "r2520" "" "r2520" "MNXR106328" "HMR_6391" "RCR20063" "" 0 "" "" "HMR_6391" +"MAR06329" "" "FAOXC8C6m" "" "" "" "FAOXC8C6m" "" "" "" "" 0 "" "" "FAOXC8C6m" +"MAR06283" "" "FAOXC6C4m" "" "" "" "FAOXC6C4m" "" "" "" "" 0 "" "" "FAOXC6C4m" +"MAR06279" "" "FAOXC61C4m" "" "" "" "FAOXC61C4m" "" "" "" "" 0 "" "" "FAOXC61C4m" +"MAR05449" "" "FAOXC4020m" "" "" "" "FAOXC4C2m" "MNXR99368" "" "" "" 0 "" "" "FAOXC4C2m" +"MAR01009" "" "FAOXC80" "" "" "" "FAOXC80" "MNXR99373" "" "" "" 0 "" "" "FAOXC80" +"MAR02532" "" "RE0702M" "" "" "" "RE0702M" "MNXR103471" "" "" "" 0 "" "" "RE0702M" +"MAR02534" "" "RE0702N" "" "" "" "RE0702N" "MNXR103471" "" "" "" 0 "" "" "RE0702N" +"MAR03748" "R01210" "OIVD2m" "R03171M" "r0600" "" "OIVD2m" "MNXR102173;MNXR107999" "HMR_3748" "RCR14420" "" 0 "" "RHEA:13997" "HMR_3748" +"MAR03780" "R03171" "OIVD3m" "R03171M" "r0602" "" "OIVD3m" "MNXR102174;MNXR107999" "HMR_3780" "RCR10345" "" 0 "" "RHEA:30907" "HMR_3780" "MAR03422" "" "" "" "" "" "HMR_3422" "" "HMR_3422" "RCR12667" "" 0 "" "" "HMR_3422" "MAR03748" "R01210" "OIVD2m" "R03171M" "r0600" "" "OIVD2m" "MNXR102173;MNXR107999" "HMR_3748" "RCR14420" "" 0 "" "RHEA:13997" "HMR_3748" "MAR03780" "R03171" "OIVD3m" "R03171M" "r0602" "" "OIVD3m" "MNXR102174;MNXR107999" "HMR_3780" "RCR10345" "" 0 "" "RHEA:30907" "HMR_3780" +"MAR00789" "" "FAOXC183803m" "" "" "" "FAOXC183803m" "MNXR99325" "" "" "" 0 "" "" "FAOXC183803m" +"MAR03426" "" "HMR_3426" "" "" "" "HMR_3426" "" "HMR_3426" "RCR12671" "" 0 "" "" "HMR_3426" +"MAR05019" "" "FAOXC10C10OHm" "" "" "" "FAOXC10C10OHm" "" "" "" "" 0 "" "" "FAOXC10C10OHm" +"MAR04967" "" "FAOXC101C8m" "" "" "" "FAOXC101C8m" "" "" "" "" 0 "" "" "FAOXC101C8m" +"MAR05024" "" "FAOXC10080m" "" "" "" "FAOXC10C8m" "MNXR99262" "" "" "" 0 "" "" "FAOXC10C8m" +"MAR03322" "" "" "RE3627X" "" "" "HMR_3322" "MNXR124610" "HMR_3322" "RCR14521" "" 0 "" "" "HMR_3322" +"MAR03296" "" "" "RE3627M" "" "R-HSA-109343" "HMR_3296" "MNXR124610" "HMR_3296" "RCR12779" "" 0 "" "" "HMR_3296" +"MAR04005" "" "" "" "" "" "RE3627C" "" "" "" "" 0 "" "" "RE3627C" "MAR00965" "" "FAOXC2252053m" "" "" "" "FAOXC2252053m" "MNXR99352" "" "" "" 0 "" "" "FAOXC2252053m" diff --git a/model/Human-GEM.yml b/model/Human-GEM.yml index a91612c5..97715655 100644 --- a/model/Human-GEM.yml +++ b/model/Human-GEM.yml @@ -46217,30 +46217,6 @@ - charge: 0 - inchis: "InChI=1S/CHNOS/c2-1-4-3/h3H" - metFrom: "Recon3D" - - !!omap - - id: "MAM02158m" - - name: "hypothiocyanite" - - compartment: "m" - - formula: "CHNOS" - - charge: 0 - - inchis: "InChI=1S/CHNOS/c2-1-4-3/h3H" - - metFrom: "Recon3D" - - !!omap - - id: "MAM02986n" - - name: "thiocyanate" - - compartment: "n" - - formula: "CNS" - - charge: -1 - - inchis: "" - - metFrom: "Recon3D" - - !!omap - - id: "MAM02158n" - - name: "hypothiocyanite" - - compartment: "n" - - formula: "CHNOS" - - charge: 0 - - inchis: "InChI=1S/CHNOS/c2-1-4-3/h3H" - - metFrom: "Recon3D" - !!omap - id: "MAM02946g" - name: "sulfate" @@ -49153,22 +49129,6 @@ - charge: -4 - inchis: "" - metFrom: "Recon3D" - - !!omap - - id: "MAM00678c" - - name: "2-trans-4-cis-decadienoyl-CoA" - - compartment: "c" - - formula: "C31H46N7O17P3S" - - charge: -4 - - inchis: "" - - metFrom: "Recon3D" - - !!omap - - id: "MAM03035c" - - name: "trans-3-decenoyl-CoA" - - compartment: "c" - - formula: "C31H48N7O17P3S" - - charge: -4 - - inchis: "" - - metFrom: "Recon3D" - !!omap - id: "MAM02891r" - name: "selenomethionine" @@ -82409,7 +82369,7 @@ - MAM02856m: 1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000083123 and ENSG00000142046 and ENSG00000248098" + - gene_reaction_rule: "ENSG00000083123 and ENSG00000137992 and ENSG00000248098" - rxnNotes: "" - rxnFrom: "HMRdatabase" - eccodes: "1.2.4.4" @@ -82446,7 +82406,7 @@ - MAM02858m: 1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000083123 and ENSG00000142046 and ENSG00000248098" + - gene_reaction_rule: "ENSG00000083123 and ENSG00000137992 and ENSG00000248098" - rxnNotes: "" - rxnFrom: "HMRdatabase" - eccodes: "1.2.4.4" @@ -86138,11 +86098,11 @@ - MAM02986c: -1 - lower_bound: -1000 - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000117592 or ENSG00000121053 or ENSG00000130508 or ENSG00000142046 or ENSG00000167419" + - gene_reaction_rule: "ENSG00000121053 or ENSG00000167419" - rxnNotes: "" - rxnFrom: "HMRdatabase" - eccodes: "1.11.1.7;1.2.4.4;1.8.1.4" - - references: "" + - references: "PMID:11013238;PMID:31989833" - subsystem: - "Cysteine and methionine metabolism" - confidence_score: 0 @@ -87514,7 +87474,7 @@ - MAM02857m: 1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000083123 and ENSG00000142046 and ENSG00000248098" + - gene_reaction_rule: "ENSG00000083123 and ENSG00000137992 and ENSG00000248098" - rxnNotes: "" - rxnFrom: "HMRdatabase" - eccodes: "1.2.4.4" @@ -102679,7 +102639,7 @@ - MAM03034m: 1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000104325 or ENSG00000242612" + - gene_reaction_rule: "ENSG00000104325" - rxnNotes: "" - rxnFrom: "HMRdatabase" - eccodes: "1.3.1.34" @@ -102858,7 +102818,7 @@ - MAM02555m: -1 - lower_bound: -1000 - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000104325 or ENSG00000242612" + - gene_reaction_rule: "ENSG00000104325" - rxnNotes: "" - rxnFrom: "HMRdatabase" - eccodes: "1.3.1.34" @@ -102927,7 +102887,7 @@ - MAM03034x: 1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000104325 or ENSG00000242612" + - gene_reaction_rule: "ENSG00000242612" - rxnNotes: "" - rxnFrom: "HMRdatabase" - eccodes: "1.3.1.34" @@ -103088,7 +103048,7 @@ - MAM02555x: -1 - lower_bound: -1000 - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000104325 or ENSG00000242612" + - gene_reaction_rule: "ENSG00000242612" - rxnNotes: "" - rxnFrom: "HMRdatabase" - eccodes: "1.3.1.34" @@ -108370,7 +108330,7 @@ - MAM02555x: 1 - lower_bound: -1000 - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000104325 or ENSG00000242612" + - gene_reaction_rule: "ENSG00000242612" - rxnNotes: "" - rxnFrom: "HMRdatabase" - eccodes: "1.3.1.34" @@ -118201,25 +118161,6 @@ - subsystem: - "Beta oxidation of di-unsaturated fatty acids (n-6) (peroxisomal)" - confidence_score: 0 - - !!omap - - id: "MAR03322" - - name: "" - - metabolites: !!omap - - MAM00678x: -1 - - MAM02039x: -1 - - MAM02552x: 1 - - MAM02553x: -1 - - MAM03035x: 1 - - lower_bound: 0 - - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000104325 or ENSG00000242612" - - rxnNotes: "" - - rxnFrom: "HMRdatabase" - - eccodes: "1.3.1.34" - - references: "PMID:7775433;PMID:11356164" - - subsystem: - - "Beta oxidation of di-unsaturated fatty acids (n-6) (peroxisomal)" - - confidence_score: 0 - !!omap - id: "MAR03323" - name: "" @@ -119183,29 +119124,6 @@ - subsystem: - "Beta oxidation of even-chain fatty acids (mitochondrial)" - confidence_score: 0 - - !!omap - - id: "MAR03426" - - name: "" - - metabolites: !!omap - - MAM01261m: 9 - - MAM01597m: -8 - - MAM01802m: -5 - - MAM01803m: 5 - - MAM02039m: 8 - - MAM02040m: -8 - - MAM02390m: -1 - - MAM02552m: -8 - - MAM02553m: 8 - - lower_bound: 0 - - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000060971 or ENSG00000072506 or ENSG00000072778 or ENSG00000084754 or ENSG00000115361 or ENSG00000117054 or ENSG00000127884 or ENSG00000138029 or ENSG00000138796 or ENSG00000167315 or ENSG00000177646" - - rxnNotes: "" - - rxnFrom: "HMRdatabase" - - eccodes: "4.2.1.17;1.1.1.35;1.1.1.211;1.3.8.7;1.3.8.8;1.3.8.9;2.3.1.16" - - references: "" - - subsystem: - - "Beta oxidation of even-chain fatty acids (mitochondrial)" - - confidence_score: 0 - !!omap - id: "MAR09719" - name: "" @@ -121214,25 +121132,6 @@ - subsystem: - "Beta oxidation of di-unsaturated fatty acids (n-6) (mitochondrial)" - confidence_score: 0 - - !!omap - - id: "MAR03296" - - name: "" - - metabolites: !!omap - - MAM00678m: -1 - - MAM02039m: -1 - - MAM02552m: 1 - - MAM02553m: -1 - - MAM03035m: 1 - - lower_bound: 0 - - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000104325 or ENSG00000242612" - - rxnNotes: "" - - rxnFrom: "HMRdatabase" - - eccodes: "1.3.1.34" - - references: "PMID:7775433;PMID:11356164" - - subsystem: - - "Beta oxidation of di-unsaturated fatty acids (n-6) (mitochondrial)" - - confidence_score: 0 - !!omap - id: "MAR03298" - name: "" @@ -121296,7 +121195,7 @@ - MAM02555m: -1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000104325 or ENSG00000242612" + - gene_reaction_rule: "ENSG00000104325" - rxnNotes: "" - rxnFrom: "HMRdatabase" - eccodes: "1.3.1.34" @@ -121387,7 +121286,7 @@ - MAM02555m: -1 - lower_bound: -1000 - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000104325 or ENSG00000242612" + - gene_reaction_rule: "ENSG00000104325" - rxnNotes: "" - rxnFrom: "HMRdatabase" - eccodes: "1.3.1.34" @@ -121496,7 +121395,7 @@ - MAM02555m: -1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000104325 or ENSG00000242612" + - gene_reaction_rule: "ENSG00000104325" - rxnNotes: "" - rxnFrom: "HMRdatabase" - eccodes: "1.3.1.34" @@ -121569,7 +121468,7 @@ - MAM02555m: -1 - lower_bound: -1000 - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000104325 or ENSG00000242612" + - gene_reaction_rule: "ENSG00000104325" - rxnNotes: "" - rxnFrom: "HMRdatabase" - eccodes: "1.3.1.34" @@ -221778,30 +221677,6 @@ - subsystem: - "Fatty acid oxidation" - confidence_score: 0 - - !!omap - - id: "MAR00789" - - name: "Beta Oxidation of Fatty Acid" - - metabolites: !!omap - - MAM01261m: 5 - - MAM01597m: -5 - - MAM01802m: -2 - - MAM01803m: 2 - - MAM02039m: 5 - - MAM02040m: -5 - - MAM02390m: -1 - - MAM02552m: -5 - - MAM02553m: 5 - - MAM02644m: 1 - - lower_bound: 0 - - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000117054 or ENSG00000122971" - - rxnNotes: "" - - rxnFrom: "Recon3D" - - eccodes: "4.2.1.74" - - references: "" - - subsystem: - - "Fatty acid oxidation" - - confidence_score: 0 - !!omap - id: "MAR00799" - name: "Beta Oxidation of Fatty Acid" @@ -222345,29 +222220,6 @@ - subsystem: - "Fatty acid oxidation" - confidence_score: 0 - - !!omap - - id: "MAR01009" - - name: "Beta Oxidation of Med/Long Chain Fatty Acid" - - metabolites: !!omap - - MAM01261m: 4 - - MAM01597m: -3 - - MAM01802m: -3 - - MAM01803m: 3 - - MAM02039m: 3 - - MAM02040m: -3 - - MAM02552m: -3 - - MAM02553m: 3 - - MAM02644m: -1 - - lower_bound: 0 - - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000117054 or ENSG00000122971" - - rxnNotes: "" - - rxnFrom: "Recon3D" - - eccodes: "1.3.99.3" - - references: "PMID:2565344;PMID:3035565" - - subsystem: - - "Fatty acid oxidation" - - confidence_score: 0 - !!omap - id: "MAR01012" - name: "Fatty Acyl Coenzyme A Synthase (N-C10:0CoA)" @@ -226714,7 +226566,7 @@ - MAM02678m: -1 - lower_bound: -1000 - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000115425 or ENSG00000116353" + - gene_reaction_rule: "ENSG00000116353" - rxnNotes: "" - rxnFrom: "Recon3D" - eccodes: "1.3.1.38" @@ -226945,7 +226797,7 @@ - MAM02644m: -1 - lower_bound: -1000 - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000115425 or ENSG00000116353" + - gene_reaction_rule: "ENSG00000116353" - rxnNotes: "" - rxnFrom: "Recon3D" - eccodes: "1.3.1.38" @@ -226964,7 +226816,7 @@ - MAM02555m: 1 - lower_bound: -1000 - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000115425 or ENSG00000116353" + - gene_reaction_rule: "ENSG00000116353" - rxnNotes: "" - rxnFrom: "Recon3D" - eccodes: "1.3.1.38" @@ -226983,7 +226835,7 @@ - MAM02555m: 1 - lower_bound: -1000 - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000115425 or ENSG00000116353" + - gene_reaction_rule: "ENSG00000116353" - rxnNotes: "" - rxnFrom: "Recon3D" - eccodes: "1.3.1.38" @@ -227040,7 +226892,7 @@ - MAM02555m: 1 - lower_bound: -1000 - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000115425 or ENSG00000116353" + - gene_reaction_rule: "ENSG00000116353" - rxnNotes: "" - rxnFrom: "Recon3D" - eccodes: "1.3.1.38" @@ -227238,7 +227090,7 @@ - MAM02555m: -1 - lower_bound: -1000 - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000115425 or ENSG00000116353" + - gene_reaction_rule: "ENSG00000116353" - rxnNotes: "" - rxnFrom: "Recon3D" - eccodes: "1.3.1.38" @@ -228286,7 +228138,7 @@ - MAM02677m: 1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "(ENSG00000138029 and ENSG00000167315) or (ENSG00000060971 and ENSG00000138029)" + - gene_reaction_rule: "ENSG00000138029 or ENSG00000167315" - rxnNotes: "" - rxnFrom: "Recon3D" - eccodes: "2.3.1.86" @@ -229246,44 +229098,6 @@ - subsystem: - "Miscellaneous" - confidence_score: 0 - - !!omap - - id: "MAR02532" - - name: "Dihydrolipoyl Dehydrogenase" - - metabolites: !!omap - - MAM02039m: -1 - - MAM02040m: 1 - - MAM02041m: -1 - - MAM02158m: 1 - - MAM02986m: -1 - - lower_bound: -1000 - - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000083123 or ENSG00000091140 or ENSG00000248098" - - rxnNotes: "" - - rxnFrom: "Recon3D" - - eccodes: "1.8.1.4" - - references: "PMID:11013238;PMID:9665099" - - subsystem: - - "Miscellaneous" - - confidence_score: 0 - - !!omap - - id: "MAR02534" - - name: "Dihydrolipoyl Dehydrogenase" - - metabolites: !!omap - - MAM02039n: -1 - - MAM02040n: 1 - - MAM02041n: -1 - - MAM02158n: 1 - - MAM02986n: -1 - - lower_bound: -1000 - - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000005381" - - rxnNotes: "" - - rxnFrom: "Recon3D" - - eccodes: "1.8.1.4" - - references: "PMID:11013238;PMID:9665099" - - subsystem: - - "Miscellaneous" - - confidence_score: 0 - !!omap - id: "MAR02536" - name: "Steryl-Sulfatase" @@ -232138,7 +231952,7 @@ - MAM03334m: 1 - lower_bound: -1000 - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000084754 or ENSG00000113790 or ENSG00000127884 or ENSG00000138029" + - gene_reaction_rule: "ENSG00000084754 or ENSG00000127884 or ENSG00000138029" - rxnNotes: "" - rxnFrom: "Recon3D" - eccodes: "4.2.1.17" @@ -232359,7 +232173,7 @@ - MAM03358m: 1 - lower_bound: -1000 - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000113790 or ENSG00000167969 or ENSG00000198721" + - gene_reaction_rule: "ENSG00000167969 or ENSG00000198721" - rxnNotes: "" - rxnFrom: "Recon3D" - eccodes: "5.3.3.8" @@ -232410,7 +232224,7 @@ - MAM03361m: -1 - lower_bound: -1000 - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000113790 or ENSG00000167969 or ENSG00000198721" + - gene_reaction_rule: "ENSG00000167969 or ENSG00000198721" - rxnNotes: "" - rxnFrom: "Recon3D" - eccodes: "5.3.3.8" @@ -232427,7 +232241,7 @@ - MAM03361m: -1 - lower_bound: -1000 - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000084754 or ENSG00000113790 or ENSG00000127884 or ENSG00000138029" + - gene_reaction_rule: "ENSG00000084754 or ENSG00000127884 or ENSG00000138029" - rxnNotes: "" - rxnFrom: "Recon3D" - eccodes: "4.2.1.17" @@ -235625,25 +235439,6 @@ - subsystem: - "Fatty acid oxidation" - confidence_score: 0 - - !!omap - - id: "MAR04005" - - name: "3-Hydroxyacyl Coenzyme A Dehydrogenase" - - metabolites: !!omap - - MAM00678c: -1 - - MAM02039c: -1 - - MAM02554c: 1 - - MAM02555c: -1 - - MAM03035c: 1 - - lower_bound: -1000 - - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000072506" - - rxnNotes: "" - - rxnFrom: "Recon3D" - - eccodes: "1.1.1.35" - - references: "PMID:11356164;PMID:7775433" - - subsystem: - - "Fatty acid oxidation" - - confidence_score: 0 - !!omap - id: "MAR04007" - name: "" @@ -239082,28 +238877,6 @@ - subsystem: - "Exchange/demand reactions" - confidence_score: 0 - - !!omap - - id: "MAR04967" - - name: "Fatty Acid Beta Oxidation (C10:1->C8), Mitochondrial" - - metabolites: !!omap - - MAM00039m: -1 - - MAM01261m: 1 - - MAM01597m: -1 - - MAM02039m: 1 - - MAM02040m: -1 - - MAM02552m: -1 - - MAM02553m: 1 - - MAM02644m: 1 - - lower_bound: 0 - - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000127884 and ENSG00000138796 and ENSG00000167315" - - rxnNotes: "" - - rxnFrom: "Recon3D" - - eccodes: "" - - references: "PMID:20195903;PMID:20490924;PMID:17143551" - - subsystem: - - "Fatty acid oxidation" - - confidence_score: 0 - !!omap - id: "MAR04968" - name: "Fatty Acid Beta Oxidation (C10:1->C8:0), Peroxisomal" @@ -239314,49 +239087,6 @@ - subsystem: - "Fatty acid oxidation" - confidence_score: 0 - - !!omap - - id: "MAR05019" - - name: "Fatty Acid Beta Oxidation (C10->Ohc10), Mitochondrial" - - metabolites: !!omap - - MAM00181m: 1 - - MAM01650m: -1 - - MAM01802m: -1 - - MAM01803m: 1 - - MAM02040m: -1 - - lower_bound: 0 - - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000117054 and ENSG00000127884" - - rxnNotes: "" - - rxnFrom: "Recon3D" - - eccodes: "" - - references: "PMID:1730577;PMID:1912723 ;PMID:7318031" - - subsystem: - - "Fatty acid oxidation" - - confidence_score: 0 - - !!omap - - id: "MAR05024" - - name: "Fatty Acid Beta Oxidation (C10->C8), Mitochondrial" - - metabolites: !!omap - - MAM01261m: 1 - - MAM01597m: -1 - - MAM01650m: -1 - - MAM01802m: -1 - - MAM01803m: 1 - - MAM02039m: 1 - - MAM02040m: -1 - - MAM02552m: -1 - - MAM02553m: 1 - - MAM02644m: 1 - - lower_bound: 0 - - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000117054 and ENSG00000127884 and ENSG00000138796 and ENSG00000167315" - - rxnNotes: "" - - rxnFrom: "Recon3D" - - eccodes: "" - - references: "PMID:20195903;PMID:20490924;PMID:17143551" - - subsystem: - - "Fatty acid oxidation" - - confidence_score: 0 - !!omap - id: "MAR05025" - name: "Fatty Acid Beta Oxidation (C10->C8), Peroxisomal" @@ -241606,29 +241336,6 @@ - subsystem: - "Fatty acid oxidation" - confidence_score: 0 - - !!omap - - id: "MAR05449" - - name: "Fatty Acid Beta Oxidation (C4->C2), Mitochondrial" - - metabolites: !!omap - - MAM01261m: 2 - - MAM01412m: -1 - - MAM01597m: -1 - - MAM01802m: -1 - - MAM01803m: 1 - - MAM02039m: 1 - - MAM02040m: -1 - - MAM02552m: -1 - - MAM02553m: 1 - - lower_bound: 0 - - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000122971 and ENSG00000127884 and ENSG00000138796 and ENSG00000167315" - - rxnNotes: "" - - rxnFrom: "Recon3D" - - eccodes: "" - - references: "PMID:20195903;PMID:20490924;PMID:17143551" - - subsystem: - - "Fatty acid oxidation" - - confidence_score: 0 - !!omap - id: "MAR05456" - name: "Succ->C4Dcc" @@ -241725,28 +241432,6 @@ - subsystem: - "Fatty acid oxidation" - confidence_score: 0 - - !!omap - - id: "MAR06279" - - name: "Fatty Acid Beta Oxidation (C6:1->C4:0), Mitochondrial" - - metabolites: !!omap - - MAM00053m: -1 - - MAM01261m: 1 - - MAM01412m: 1 - - MAM01597m: -1 - - MAM02039m: 1 - - MAM02040m: -1 - - MAM02552m: -1 - - MAM02553m: 1 - - lower_bound: 0 - - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000127884 and ENSG00000138796 and ENSG00000167315" - - rxnNotes: "" - - rxnFrom: "Recon3D" - - eccodes: "" - - references: "PMID:20195903;PMID:20490924;PMID:17143551" - - subsystem: - - "Fatty acid oxidation" - - confidence_score: 0 - !!omap - id: "MAR06280" - name: "Fatty Acid Beta Oxidation (C6:1->C4:0), Peroxisomal" @@ -241801,30 +241486,6 @@ - subsystem: - "Fatty acid oxidation" - confidence_score: 0 - - !!omap - - id: "MAR06283" - - name: "Fatty Acid Beta Oxidation (C6->C4), Mitochondrial" - - metabolites: !!omap - - MAM01261m: 1 - - MAM01412m: 1 - - MAM01597m: -1 - - MAM01802m: -1 - - MAM01803m: 1 - - MAM02039m: 1 - - MAM02040m: -1 - - MAM02122m: -1 - - MAM02552m: -1 - - MAM02553m: 1 - - lower_bound: 0 - - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000117054 and ENSG00000127884 and ENSG00000138796 and ENSG00000167315" - - rxnNotes: "" - - rxnFrom: "Recon3D" - - eccodes: "" - - references: "PMID:20195903;PMID:20490924;PMID:17143551" - - subsystem: - - "Fatty acid oxidation" - - confidence_score: 0 - !!omap - id: "MAR06284" - name: "Fatty Acid Beta Oxidation (C6->C4), Peroxisomal" @@ -241945,30 +241606,6 @@ - subsystem: - "Fatty acid oxidation" - confidence_score: 0 - - !!omap - - id: "MAR06329" - - name: "Fatty Acid Beta Oxidation (C8->C6), Mitochondrial" - - metabolites: !!omap - - MAM01261m: 1 - - MAM01597m: -1 - - MAM01802m: -1 - - MAM01803m: 1 - - MAM02039m: 1 - - MAM02040m: -1 - - MAM02122m: 1 - - MAM02552m: -1 - - MAM02553m: 1 - - MAM02644m: -1 - - lower_bound: 0 - - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000117054 and ENSG00000127884 and ENSG00000138796 and ENSG00000167315" - - rxnNotes: "" - - rxnFrom: "Recon3D" - - eccodes: "" - - references: "PMID:20195903;PMID:20490924;PMID:17143551" - - subsystem: - - "Fatty acid oxidation" - - confidence_score: 0 - !!omap - id: "MAR06344" - name: "Fatty Acid Beta Oxidation (C8->C6), Peroxisomal" @@ -309575,9 +309212,6 @@ - !!omap - id: "ENSG00000141959" - name: "PFKL" - - !!omap - - id: "ENSG00000142046" - - name: "TMEM91" - !!omap - id: "ENSG00000142082" - name: "SIRT3" diff --git a/model/genes.tsv b/model/genes.tsv index cdd14823..8ed13e63 100644 --- a/model/genes.tsv +++ b/model/genes.tsv @@ -1465,7 +1465,6 @@ genes geneENSTID geneENSPID geneUniProtID geneSymbols geneEntrezID geneNames gen "ENSG00000141873" "ENST00000545664;ENST00000269740;ENST00000589363;ENST00000589166;ENST00000455372;ENST00000590875" "ENSP00000445345;ENSP00000269740;ENSP00000465383;ENSP00000466969;ENSP00000393715" "Q9BRY0" "SLC39A3" "29985" "solute carrier family 39 member 3" "ZIP3" "Cell membrane;Golgi apparatus" "DeepLoc2" "ENSG00000141934" "ENST00000327790;ENST00000434325;ENST00000269812;ENST00000621795;ENST00000633125;ENST00000586998;ENST00000591572;ENST00000589672" "ENSP00000329697;ENSP00000388565;ENSP00000269812;ENSP00000488312;ENSP00000466947;ENSP00000466545" "O43688" "PLPP2" "8612" "phospholipid phosphatase 2" "LPP2;PAP-2c;PPAP2C" "Endoplasmic reticulum" "SwissProt" "ENSG00000141959" "ENST00000397961;ENST00000349048;ENST00000496824;ENST00000466134;ENST00000628044;ENST00000491298;ENST00000474114;ENST00000498841;ENST00000460020;ENST00000467315;ENST00000460521;ENST00000495274" "ENSP00000381052;ENSP00000269848;ENSP00000486076" "P17858" "PFKL" "5211" "phosphofructokinase, liver type" "" "Mitochondria;Nucleus;Cytosol" "SwissProt;CellAtlas" -"ENSG00000142046" "ENST00000539627;ENST00000604123;ENST00000413014;ENST00000392002;ENST00000436170;ENST00000447302;ENST00000544232;ENST00000542945;ENST00000537354;ENST00000342187;ENST00000356385;ENST00000546050;ENST00000546362;ENST00000535712" "ENSP00000441900;ENSP00000474871;ENSP00000413192;ENSP00000375859;ENSP00000407003;ENSP00000405647;ENSP00000437779;ENSP00000440225;ENSP00000437868;ENSP00000345589;ENSP00000348750;ENSP00000440752;ENSP00000441729;ENSP00000443375" "Q6ZNR0" "TMEM91" "641649" "transmembrane protein 91" "DSPC3;FLJ27310;IFITMD6" "Cell membrane" "DeepLoc2" "ENSG00000142082" "ENST00000382743;ENST00000529937;ENST00000532837;ENST00000525319;ENST00000524564;ENST00000532956;ENST00000529382;ENST00000531753;ENST00000526854;ENST00000529055;ENST00000528702;ENST00000534381;ENST00000530067;ENST00000528469;ENST00000525776;ENST00000525237" "ENSP00000372191;ENSP00000434747;ENSP00000433899;ENSP00000435464;ENSP00000432937;ENSP00000433077;ENSP00000437216;ENSP00000435505;ENSP00000437179;ENSP00000435014;ENSP00000432857;ENSP00000433132;ENSP00000436085" "Q9NTG7" "SIRT3" "23410" "sirtuin 3" "SIR2L3" "Mitochondria" "SwissProt" "ENSG00000142102" "ENST00000409548;ENST00000474221;ENST00000409655;ENST00000529087;ENST00000409479;ENST00000482937;ENST00000476372;ENST00000397660" "ENSP00000387185;ENSP00000386297;ENSP00000387099;ENSP00000431881;ENSP00000380780" "Q32M88" "PGGHG" "80162" "protein-glucosylgalactosylhydroxylysine glucosidase" "ATHL1;FLJ22635" "Cytosol" "CellAtlas" "ENSG00000142168" "ENST00000270142;ENST00000389995;ENST00000476106;ENST00000470944" "ENSP00000270142;ENSP00000374645" "P00441" "SOD1" "6647" "superoxide dismutase 1" "ALS;ALS1;IPOA" "Mitochondria;Nucleus;Cytosol" "SwissProt;CellAtlas" diff --git a/model/metabolites.tsv b/model/metabolites.tsv index 6e52173c..ffb1efa6 100644 --- a/model/metabolites.tsv +++ b/model/metabolites.tsv @@ -5775,9 +5775,6 @@ mets metsNoComp metBiGGID metKEGGID metHMDBID metChEBIID metPubChemID metLipidMa "MAM02158e" "MAM02158" "" "" "" "" "124985" "" "CE2011" "" "CE2011" "MNXM57006" "" "m02158s" "MAM02986l" "MAM02986" "tcynt" "C01755" "HMDB0001453" "CHEBI:18022" "9322" "" "" "" "tcynt" "MNXM762" "" "m02986l" "MAM02158l" "MAM02158" "" "" "" "" "124985" "" "CE2011" "" "CE2011" "MNXM57006" "" "m02158l" -"MAM02158m" "MAM02158" "" "" "" "" "124985" "" "CE2011" "" "CE2011" "MNXM57006" "" "m02158m" -"MAM02986n" "MAM02986" "tcynt" "C01755" "HMDB0001453" "CHEBI:18022" "9322" "" "" "" "tcynt" "MNXM762" "" "m02986n" -"MAM02158n" "MAM02158" "" "" "" "" "124985" "" "CE2011" "" "CE2011" "MNXM57006" "" "m02158n" "MAM02946g" "MAM02946" "so4" "C00059" "HMDB0001448" "CHEBI:16189" "1117" "" "" "HC00062" "so4" "MNXM58" "" "m02946g" "MAM00721g" "MAM00721" "" "" "" "" "" "" "CE2870" "" "CE2870" "MNXM164192" "" "m00721g" "MAM00720g" "MAM00720" "" "" "" "" "107564" "" "CE2866" "" "CE2866" "MNXM1986" "" "m00720g" @@ -6142,8 +6139,6 @@ mets metsNoComp metBiGGID metKEGGID metHMDBID metChEBIID metPubChemID metLipidMa "MAM00329x" "MAM00329" "" "" "" "" "53481457" "" "CE5525" "" "CE5525" "MNXM33276" "" "m00329p" "MAM00328x" "MAM00328" "" "" "" "" "53481456" "" "CE5976" "" "CE5976" "MNXM33275" "" "m00328p" "MAM03352x" "MAM03352" "" "" "" "" "" "" "CE4794" "" "CE4794" "" "" "CE4794_p" -"MAM00678c" "MAM00678" "" "" "" "" "22833562" "" "CE2435" "" "dec24dicoa" "MNXM1601" "" "m00678c" -"MAM03035c" "MAM03035" "" "" "" "" "16019966" "" "CE5121" "" "dece3coa" "MNXM90096" "" "m03035c" "MAM02891r" "MAM02891" "selmeth" "C05335" "HMDB0003966" "CHEBI:27585" "15103" "" "" "" "selmeth" "MNXM1676" "" "m02891r" "MAM02892r" "MAM02892" "" "C05708" "" "" "17754089" "" "" "" "C05708" "MNXM81813" "" "m02892r" "MAM01115n" "MAM01115" "5mthf" "C00440" "HMDB0001396" "CHEBI:15641" "439234" "" "" "HC00358" "5mthf" "MNXM318" "" "m01115n" diff --git a/model/reactions.tsv b/model/reactions.tsv index 8eb9d439..86b32a6f 100644 --- a/model/reactions.tsv +++ b/model/reactions.tsv @@ -178,7 +178,7 @@ rxns rxnKEGGID rxnBiGGID rxnEHMNID rxnHepatoNET1ID rxnREACTOMEID rxnRecon3DID rx "MAR00719" "R08198" "" "" "" "" "HMR_0719" "MNXR111769" "HMR_0719" "RCR11097" "" 0 "" "RHEA:13449" "HMR_0719" "MAR01434" "R00238" "ACACT1r" "R00238M" "r0069" "" "ACACT1r" "MNXR95194" "HMR_1434" "RCR10465" "" 0 "RHEA:21039" "RHEA:21036" "HMR_1434" "MAR01436" "R01357" "AACOAT" "R01357M" "r0320" "" "AACOAT" "MNXR95136" "HMR_1436" "RCR10466" "" 0 "RHEA:16118" "RHEA:16117" "HMR_1436" -"MAR03163" "R01175" "ACOAD1fm" "" "" "R-HSA-77319" "ACOAD1fm;HMR_3422" "MNXR95302" "HMR_3163;HMR_3422" "RCR11098;RCR12667" "" 0 "" "RHEA:24004" "HMR_3163;HMR_3422;MAR03422" +"MAR03163" "R01175" "ACOAD1fm;FAOXC4020m;FAOXC80;HMR_3426" "" "" "R-HSA-77319" "ACOAD1fm;FAOXC4C2m;FAOXC80;HMR_3422;HMR_3426" "MNXR95302" "HMR_3163;HMR_3422;HMR_3426" "RCR11098;RCR12667;RCR12671" "" 0 "" "RHEA:24004" "HMR_3163;FAOXC4C2m;MAR05449;FAOXC80;MAR01009;HMR_3422;MAR03422;HMR_3426;MAR03426" "MAR04461" "R01361" "BDHm" "R01361C" "r0323" "" "BDHm" "MNXR96232" "HMR_4461" "RCR10467" "" 0 "RHEA:20524" "RHEA:20521" "HMR_4461" "MAR04604" "R01978" "" "R01978C" "r0463" "" "r0463" "MNXR100660;MNXR107257" "HMR_4604" "RCR11099" "" 0 "" "RHEA:10188" "HMR_4604" "MAR05351" "R01000" "" "" "" "" "2HBO" "MNXR94796" "HMR_5351" "RCR10152" "" 0 "" "RHEA:36371" "HMR_5351" @@ -740,9 +740,9 @@ rxns rxnKEGGID rxnBiGGID rxnEHMNID rxnHepatoNET1ID rxnREACTOMEID rxnRecon3DID rx "MAR08026" "" "LYSMTF2n" "" "" "" "LYSMTF2n" "MNXR101260" "HMR_8026" "RCR11349" "" 0 "" "" "HMR_8026" "MAR08027" "R04867" "LYSMTF3n" "" "" "" "LYSMTF3n" "MNXR101261" "HMR_8027" "RCR11350" "" 0 "" "RHEA:54200" "HMR_8027" "MAR08029" "" "PLYSPSer" "" "" "" "PLYSPSer" "MNXR103039" "HMR_8029" "RCR14338" "" 0 "" "" "HMR_8029" -"MAR03164" "R03026" "ECOAH1m" "R03026M" "r0588" "" "ECOAH1m;HMR_3422" "MNXR97883" "HMR_3164;HMR_3422" "RCR11351;RCR12667" "" 0 "" "RHEA:26558" "HMR_3164;HMR_3422;MAR03422" -"MAR03166" "R01975" "HACD1m" "R01975M" "r0460" "" "HACD1m;HMR_3422" "MNXR100541" "HMR_3166;HMR_3422" "RCR11352;RCR12667" "" 0 "" "RHEA:30799" "HMR_3166;HMR_3422;MAR03422" -"MAR03885" "R00238" "ACACT1m" "R00238M" "r0070" "" "ACACT1rm;HMR_3422" "MNXR95194" "HMR_3885;HMR_3422" "RCR10247;RCR12667" "" 0 "RHEA:21039" "RHEA:21036" "HMR_3885;HMR_3422;MAR03422" +"MAR03164" "R03026" "ECOAH1m;FAOXC4020m;FAOXC80;HMR_3426" "R03026M" "r0588" "" "ECOAH1m;FAOXC4C2m;FAOXC80;HMR_3422;HMR_3426" "MNXR97883" "HMR_3164;HMR_3422;HMR_3426" "RCR11351;RCR12667;RCR12671" "" 0 "" "RHEA:26558" "HMR_3164;FAOXC4C2m;MAR05449;FAOXC80;MAR01009;HMR_3422;MAR03422;HMR_3426;MAR03426" +"MAR03166" "R01975" "HACD1m;FAOXC4020m;FAOXC80;HMR_3426" "R01975M" "r0460" "" "HACD1m;FAOXC4C2m;FAOXC80;HMR_3422;HMR_3426" "MNXR100541" "HMR_3166;HMR_3422;HMR_3426" "RCR11352;RCR12667;RCR12671" "" 0 "" "RHEA:30799" "HMR_3166;FAOXC4C2m;MAR05449;FAOXC80;MAR01009;HMR_3422;MAR03422;HMR_3426;MAR03426" +"MAR03885" "R00238" "ACACT1m;FAOXC4020m;FAOXC80;HMR_3426" "R00238M" "r0070" "" "ACACT1rm;FAOXC4C2m;FAOXC80;HMR_3422;HMR_3426" "MNXR95194" "HMR_3885;HMR_3422;HMR_3426" "RCR10247;RCR12667;RCR12671" "" 0 "RHEA:21039" "RHEA:21036" "HMR_3885;FAOXC4C2m;MAR05449;FAOXC80;MAR01009;HMR_3422;MAR03422;HMR_3426;MAR03426" "MAR04250" "R04293" "QUILSYN" "" "r0675" "" "QUILSYN" "MNXR103396" "HMR_4250" "RCR11353" "" 1 "" "RHEA:25147" "HMR_4250" "MAR08091" "" "3HXKYNDCL" "" "" "" "3HXKYNDCL" "MNXR94906" "HMR_8091" "RCR11354" "" 0 "" "" "HMR_8091" "MAR08092" "R04907" "3HXKYNOXDA" "" "" "" "3HXKYNOXDA" "MNXR94907" "HMR_8092" "RCR11355" "" 0 "" "" "HMR_8092" @@ -2617,7 +2617,6 @@ rxns rxnKEGGID rxnBiGGID rxnEHMNID rxnHepatoNET1ID rxnREACTOMEID rxnRecon3DID rx "MAR03319" "" "" "RE1527X" "" "" "RE1527X" "" "HMR_3319" "RCR12618" "" 0 "" "" "HMR_3319" "MAR03320" "" "" "RE1534X" "" "" "RE1534X" "" "HMR_3320" "RCR12619" "" 0 "" "" "HMR_3320" "MAR03321" "" "" "RE1519X" "" "" "HMR_3321" "" "HMR_3321" "RCR12620" "" 0 "" "" "HMR_3321" -"MAR03322" "" "" "RE3627X" "" "" "HMR_3322" "MNXR124610" "HMR_3322" "RCR14521" "" 0 "" "" "HMR_3322" "MAR03323" "" "" "" "" "" "FAOXC101x" "" "HMR_3323" "RCR14522" "" 0 "" "" "HMR_3323" "MAR03107" "" "" "" "" "" "HMR_3107" "" "HMR_3107" "RCR12621" "" 0 "" "" "HMR_3107" "MAR03108" "" "" "" "" "" "HMR_3108" "" "HMR_3108" "RCR12622" "" 0 "" "" "HMR_3108" @@ -2643,18 +2642,18 @@ rxns rxnKEGGID rxnBiGGID rxnEHMNID rxnHepatoNET1ID rxnREACTOMEID rxnRecon3DID rx "MAR03136" "R04170" "r1446" "R04170X" "r0660" "" "r0660;r1446" "MNXR97890" "HMR_3136" "RCR12642" "" 0 "" "RHEA:31075" "HMR_3136;r1446;MAR02366" "MAR03137" "R04741" "" "R04741X" "r0722" "" "r0722" "MNXR100546" "HMR_3137" "RCR12643" "" 0 "" "RHEA:31179" "HMR_3137" "MAR03139" "R04742" "" "R04742X" "r0724" "" "r0724" "MNXR95199;MNXR95200" "HMR_3139" "RCR12644" "" 0 "RHEA:31185" "RHEA:31183" "HMR_3139" -"MAR03142" "R04754" "r1451" "" "" "R-HSA-77345" "HMR_3142;r1451" "MNXR109095" "HMR_3142" "RCR12645" "" 0 "" "RHEA:28354" "HMR_3142;r1451;MAR02373" -"MAR03143" "R04744" "" "R04744X" "r0728" "" "r0728;HMR_3422" "MNXR97889" "HMR_3143;HMR_3422" "RCR12646;RCR12667" "" 0 "" "RHEA:31191" "HMR_3143;HMR_3422;MAR03422" -"MAR03144" "R04743" "" "R04743X" "r0726" "" "r0726;HMR_3422" "MNXR100545" "HMR_3144;HMR_3422" "RCR12647;RCR12667" "" 0 "" "RHEA:31187" "HMR_3144;HMR_3422;MAR03422" -"MAR03146" "R03778" "" "R03778X" "r0634" "" "r0634;HMR_3422" "MNXR95198" "HMR_3146;HMR_3422" "RCR12648;RCR12667" "" 0 "RHEA:31089" "RHEA:31087" "HMR_3146;HMR_3422;MAR03422" -"MAR03149" "R03777" "r1448" "" "" "R-HSA-77338" "HMR_3149;r1448;HMR_3422" "MNXR95304" "HMR_3149;HMR_3422" "RCR12649;RCR12667" "" 0 "" "RHEA:30943" "HMR_3149;r1448;MAR02369;HMR_3422;MAR03422" -"MAR03150" "R04746" "" "R04746M" "r0731" "" "r0731;HMR_3422" "MNXR97888" "HMR_3150;HMR_3422" "RCR12650;RCR12667" "" 0 "" "RHEA:31199" "HMR_3150;HMR_3422;MAR03422" -"MAR03151" "R04745" "" "R04745M" "r0730" "" "r0730;HMR_3422" "MNXR100544" "HMR_3151;HMR_3422" "RCR12651;RCR12667" "" 0 "" "RHEA:31195" "HMR_3151;HMR_3422;MAR03422" -"MAR03153" "R04747" "" "R04747M" "r0732" "" "r0732;HMR_3422" "MNXR109092" "HMR_3153;HMR_3422" "RCR12652;RCR12667" "" 0 "RHEA:31205" "RHEA:31203" "HMR_3153;HMR_3422;MAR03422" -"MAR03156" "R04751" "r1450" "" "" "R-HSA-77327" "HMR_3156;r1450;HMR_3422" "MNXR109093" "HMR_3156;HMR_3422" "RCR12653;RCR12667" "" 0 "" "RHEA:31207" "HMR_3156;r1450;MAR02372;HMR_3422;MAR03422" -"MAR03157" "R04749" "" "R04749M" "r0734" "" "r0734;HMR_3422" "MNXR97886" "HMR_3157;HMR_3422" "RCR12654;RCR12667" "" 0 "" "RHEA:30547" "HMR_3157;HMR_3422;MAR03422" -"MAR03158" "R04748" "" "R04748M" "r0733" "R-HSA-77323" "r0733;HMR_3422" "MNXR100543" "HMR_3158;HMR_3422" "RCR12655;RCR12667" "" 0 "" "RHEA:31143" "HMR_3158;HMR_3422;MAR03422" -"MAR03160" "R01177" "" "R01177M" "r0287" "R-HSA-77321" "r0287;HMR_3422" "MNXR95196" "HMR_3160;HMR_3422" "RCR12656;RCR12667" "" 0 "" "RHEA:31111" "HMR_3160;HMR_3422;MAR03422" +"MAR03142" "R04754" "r1451;FAOXC10C10OHm;FAOXC10080m" "" "" "R-HSA-77345" "HMR_3142;r1451;FAOXC10C10OHm;FAOXC10C8m" "MNXR109095" "HMR_3142" "RCR12645" "" 0 "" "RHEA:28354" "HMR_3142;r1451;MAR02373;FAOXC10C10OHm;MAR05019;FAOXC10C8m;MAR05024" +"MAR03143" "R04744" "FAOXC10C10OHm;FAOXC101C8m;FAOXC10080m" "R04744X" "r0728" "" "r0728;HMR_3422;FAOXC10C10OHm;FAOXC101C8m;FAOXC10C8m" "MNXR97889" "HMR_3143;HMR_3422" "RCR12646;RCR12667" "" 0 "" "RHEA:31191" "HMR_3143;HMR_3422;MAR03422;FAOXC10C10OHm;MAR05019;FAOXC101C8m;MAR04967;FAOXC10C8m;MAR05024" +"MAR03144" "R04743" "FAOXC101C8m;FAOXC10080m" "R04743X" "r0726" "" "r0726;HMR_3422;FAOXC101C8m;FAOXC10C8m" "MNXR100545" "HMR_3144;HMR_3422" "RCR12647;RCR12667" "" 0 "" "RHEA:31187" "HMR_3144;HMR_3422;MAR03422;FAOXC101C8m;MAR04967;FAOXC10C8m;MAR05024" +"MAR03146" "R03778" "FAOXC101C8m;FAOXC10080m" "R03778X" "r0634" "" "r0634;HMR_3422;FAOXC101C8m;FAOXC10C8m" "MNXR95198" "HMR_3146;HMR_3422" "RCR12648;RCR12667" "" 0 "RHEA:31089" "RHEA:31087" "HMR_3146;HMR_3422;MAR03422;FAOXC101C8m;MAR04967;FAOXC10C8m;MAR05024" +"MAR03149" "R03777" "r1448;FAOXC8C6m;FAOXC80" "" "" "R-HSA-77338" "HMR_3149;r1448;FAOXC6C8m;FAOXC80;HMR_3422" "MNXR95304" "HMR_3149;HMR_3422" "RCR12649;RCR12667" "" 0 "" "RHEA:30943" "HMR_3149;r1448;MAR02369;FAOXC8C6m;MAR06329;FAOXC80;MAR01009;HMR_3422;MAR03422" +"MAR03150" "R04746" "FAOXC8C6m;FAOXC80" "R04746M" "r0731" "" "r0731;FAOXC8C6m;FAOXC80;HMR_3422" "MNXR97888" "HMR_3150;HMR_3422" "RCR12650;RCR12667" "" 0 "" "RHEA:31199" "HMR_3150;FAOXC6C8m;MAR06329;FAOXC80;MAR01009;HMR_3422;MAR03422" +"MAR03151" "R04745" "FAOXC8C6m;FAOXC80" "R04745M" "r0730" "" "r0730;FAOXC8C6m;FAOXC80;HMR_3422" "MNXR100544" "HMR_3151;HMR_3422" "RCR12651;RCR12667" "" 0 "" "RHEA:31195" "HMR_3151;FAOXC8C6m;MAR06329;FAOXC80;MAR01009;HMR_3422;MAR03422" +"MAR03153" "R04747" "FAOXC8C6m;FAOXC80" "R04747M" "r0732" "" "r0732;FAOXC8C6m;FAOXC80;HMR_3422" "MNXR109092" "HMR_3153;HMR_3422" "RCR12652;RCR12667" "" 0 "RHEA:31205" "RHEA:31203" "HMR_3153;FAOXC8C6m;MAR06329;FAOXC80;MAR01009;HMR_3422;MAR03422" +"MAR03156" "R04751" "r1450;FAOXC6C4m;FAOXC80" "" "" "R-HSA-77327" "HMR_3156;r1450;FAOXC6C4m;FAOXC80;HMR_3422" "MNXR109093" "HMR_3156;HMR_3422" "RCR12653;RCR12667" "" 0 "" "RHEA:31207" "HMR_3156;r1450;MAR02372;FAOXC6C4m;MAR06283;FAOXC80;MAR01009;HMR_3422;MAR03422" +"MAR03157" "R04749" "FAOXC6C4m;FAOXC61C4m;FAOXC80;HMR_3426" "R04749M" "r0734" "" "r0734;FAOXC6C4m;FAOXC61C4m;FAOXC80;HMR_3422;HMR_3426" "MNXR97886" "HMR_3157;HMR_3422;HMR_3426" "RCR12654;RCR12667;RCR12671" "" 0 "" "RHEA:30547" "HMR_3157;FAOXC6C4m;MAR06283;FAOXC61C4m;MAR06279;FAOXC80;MAR01009;HMR_3422;MAR03422;HMR_3426;MAR03426" +"MAR03158" "R04748" "FAOXC6C4m;FAOXC61C4m;FAOXC80;HMR_3426" "R04748M" "r0733" "R-HSA-77323" "r0733;FAOXC6C4m;FAOXC61C4m;FAOXC80;HMR_3422;HMR_3426" "MNXR100543" "HMR_3158;HMR_3422;HMR_3426" "RCR12655;RCR12667;RCR12671" "" 0 "" "RHEA:31143" "HMR_3158;FAOXC6C4m;MAR06283;FAOXC61C4m;MAR06279;FAOXC80;MAR01009;HMR_3422;MAR03422;HMR_3426;MAR03426" +"MAR03160" "R01177" "FAOXC6C4m;FAOXC61C4m;FAOXC80;HMR_3426" "R01177M" "r0287" "R-HSA-77321" "r0287;FAOXC6C4m;FAOXC61C4m;FAOXC80;HMR_3422;HMR_3426" "MNXR95196" "HMR_3160;HMR_3422;HMR_3426" "RCR12656;RCR12667;RCR12671" "" 0 "" "RHEA:31111" "HMR_3160;FAOXC6C4m;MAR06283;FAOXC61C4m;MAR06279;FAOXC80;MAR01009;HMR_3422;MAR03422;HMR_3426;MAR03426" "MAR03398" "" "HMR_3398" "" "" "" "HMR_3398" "" "HMR_3398" "RCR12657" "" 0 "" "" "HMR_3398" "MAR03406" "" "HMR_3406" "" "" "" "HMR_3406" "" "HMR_3406" "RCR12658" "" 0 "" "" "HMR_3406" "MAR03407" "" "" "" "" "" "HMR_3407" "" "HMR_3407" "RCR12659" "" 0 "" "" "HMR_3407" @@ -2668,7 +2667,6 @@ rxns rxnKEGGID rxnBiGGID rxnEHMNID rxnHepatoNET1ID rxnREACTOMEID rxnRecon3DID rx "MAR03423" "" "HMR_3423" "" "" "" "HMR_3423" "" "HMR_3423" "RCR12668" "" 0 "" "" "HMR_3423" "MAR03424" "" "" "" "" "" "HMR_3424" "" "HMR_3424" "RCR12669" "" 0 "" "" "HMR_3424" "MAR03425" "" "" "" "" "" "HMR_3425" "" "HMR_3425" "RCR12670" "" 0 "" "" "HMR_3425" -"MAR03426" "" "HMR_3426" "" "" "" "HMR_3426" "" "HMR_3426" "RCR12671" "" 0 "" "" "HMR_3426" "MAR09719" "" "" "" "" "" "HMR_9719" "" "HMR_9719" "RCR12672" "" 0 "" "" "HMR_9719" "MAR03427" "" "" "" "" "" "HMR_3427" "" "HMR_3427" "RCR12673" "" 0 "" "" "HMR_3427" "MAR03428" "" "" "" "" "" "HMR_3428" "" "HMR_3428" "RCR12674" "" 0 "" "" "HMR_3428" @@ -2778,7 +2776,6 @@ rxns rxnKEGGID rxnBiGGID rxnEHMNID rxnHepatoNET1ID rxnREACTOMEID rxnRecon3DID rx "MAR03292" "" "" "RE1527M" "" "" "RE1527M" "" "HMR_3292" "RCR12776" "" 0 "" "" "HMR_3292" "MAR03293" "" "" "RE1534M" "" "" "RE1534M" "" "HMR_3293" "RCR12777" "" 0 "" "" "HMR_3293" "MAR03294" "" "" "RE1519M" "" "" "FAOXC101C102m;HMR_3422" "" "HMR_3294;HMR_3422" "RCR12778;RCR12667" "" 0 "" "" "HMR_3294;HMR_3422;MAR03422" -"MAR03296" "" "" "RE3627M" "" "R-HSA-109343" "HMR_3296" "MNXR124610" "HMR_3296" "RCR12779" "" 0 "" "" "HMR_3296" "MAR03298" "" "" "RE3628M" "" "R-HSA-109998" "RE3628M;FAOXC101m;HMR_3422" "MNXR118942" "HMR_3298;HMR_3422" "RCR12780;RCR12667" "" 0 "RHEA:45753" "RHEA:45752" "HMR_3298;HMR_3422;MAR03422" "MAR01174" "" "" "RE3383M" "" "" "RE3383M" "" "HMR_1174" "RCR12781" "" 0 "" "" "HMR_1174" "MAR01175" "" "" "RE3385M" "" "" "RE3385M" "" "HMR_1175" "RCR12782" "" 0 "" "" "HMR_1175" @@ -8263,7 +8260,6 @@ rxns rxnKEGGID rxnBiGGID rxnEHMNID rxnHepatoNET1ID rxnREACTOMEID rxnRecon3DID rx "MAR00784" "" "FAOXC1811603m" "" "" "" "FAOXC1811603m" "MNXR99317" "" "" "" 0 "" "" "FAOXC1811603m" "MAR00785" "" "FAOXC182806m" "" "" "" "FAOXC182806m" "MNXR99321" "" "" "" 0 "" "" "FAOXC182806m" "MAR00788" "" "FAOXC18280m" "" "" "" "FAOXC18280m" "MNXR99322" "" "" "" 0 "" "" "FAOXC18280m" -"MAR00789" "" "FAOXC183803m" "" "" "" "FAOXC183803m" "MNXR99325" "" "" "" 0 "" "" "FAOXC183803m" "MAR00799" "" "FAOXC183806m" "" "" "" "FAOXC183806m" "MNXR99326" "" "" "" 0 "" "" "FAOXC183806m" "MAR00800" "" "FAOXC183806x" "" "" "" "FAOXC183806x" "MNXR99326" "" "" "" 0 "" "" "FAOXC183806x" "MAR00818" "" "FAOXC18480m" "" "" "" "FAOXC18480m" "MNXR99330" "" "" "" 0 "" "" "FAOXC18480m" @@ -8287,7 +8283,6 @@ rxns rxnKEGGID rxnBiGGID rxnEHMNID rxnHepatoNET1ID rxnREACTOMEID rxnRecon3DID rx "MAR00982" "" "FAOXC2452256x" "" "" "" "FAOXC2452256x" "MNXR99365" "" "" "" 0 "" "" "FAOXC2452256x" "MAR01001" "" "FAOXC246226x" "" "" "" "FAOXC246226x" "MNXR99366" "" "" "" 0 "" "" "FAOXC246226x" "MAR01005" "" "FAOXC260240x" "" "" "" "FAOXC260240x" "MNXR99367" "" "" "" 0 "" "" "FAOXC260240x" -"MAR01009" "" "FAOXC80" "" "" "" "FAOXC80" "MNXR99373" "" "" "" 0 "" "" "FAOXC80" "MAR01012" "" "FAS100COA" "" "" "" "FAS100COA" "MNXR99385" "" "" "" 0 "" "" "FAS100COA" "MAR01019" "" "FAS120COA" "" "" "" "FAS120COA" "MNXR99389" "" "" "" 0 "" "" "FAS120COA" "MAR01024" "" "FAS140COA" "" "" "" "FAS140COA" "MNXR99393" "" "" "" 0 "" "" "FAS140COA" @@ -8672,8 +8667,6 @@ rxns rxnKEGGID rxnBiGGID rxnEHMNID rxnHepatoNET1ID rxnREACTOMEID rxnRecon3DID rx "MAR02527" "" "RE0691C" "" "" "" "RE0691C" "MNXR103470" "" "" "" 0 "RHEA:22591" "RHEA:22588" "RE0691C" "MAR02529" "" "RE0702E" "" "" "" "RE0702E" "MNXR103471" "" "" "" 0 "" "" "RE0702E" "MAR02531" "" "RE0702L" "" "" "" "RE0702L" "MNXR103471" "" "" "" 0 "" "" "RE0702L" -"MAR02532" "" "RE0702M" "" "" "" "RE0702M" "MNXR103471" "" "" "" 0 "" "" "RE0702M" -"MAR02534" "" "RE0702N" "" "" "" "RE0702N" "MNXR103471" "" "" "" 0 "" "" "RE0702N" "MAR02536" "" "" "" "" "" "RE0908G" "" "" "" "" 0 "" "" "RE0908G" "MAR02538" "" "" "" "" "" "RE0908R" "" "" "" "" 0 "" "" "RE0908R" "MAR02539" "" "" "" "" "" "RE0916G" "" "" "" "" 0 "" "" "RE0916G" @@ -9012,7 +9005,6 @@ rxns rxnKEGGID rxnBiGGID rxnEHMNID rxnHepatoNET1ID rxnREACTOMEID rxnRecon3DID rx "MAR03997" "" "RE3624M" "" "" "" "RE3624M" "" "" "" "" 0 "" "" "RE3624M" "MAR04001" "" "" "" "" "" "RE3624X" "" "" "" "" 0 "" "" "RE3624X" "MAR04003" "" "RE3626M" "" "" "" "RE3626M" "" "" "" "" 0 "" "" "RE3626M" -"MAR04005" "" "" "" "" "" "RE3627C" "" "" "" "" 0 "" "" "RE3627C" "MAR04007" "" "RE3636C" "" "" "" "RE3636C" "MNXR103991" "" "" "" 0 "" "" "RE3636C" "MAR04009" "" "RN0001R" "" "" "" "RN0001R" "MNXR104044" "" "" "" 0 "" "" "RN0001R" "MAR04011" "" "RN0002N" "" "" "" "RN0002N" "MNXR104045" "" "" "" 0 "" "" "RN0002N" @@ -9222,20 +9214,17 @@ rxns rxnKEGGID rxnBiGGID rxnEHMNID rxnHepatoNET1ID rxnREACTOMEID rxnRecon3DID rx "MAR04943" "" "EX_ivcrn_e" "" "" "" "EX_ivcrn[e]" "MNXR98685" "" "" "" 0 "" "" "EX_ivcrn[e]" "MAR04950" "" "EX_tetdec2crn_e" "" "" "" "EX_tetdec2crn[e]" "" "" "" "" 0 "" "" "EX_tetdec2crn[e]" "MAR04965" "" "EX_tetdece1crn_e" "" "" "" "EX_tetdece1crn[e]" "" "" "" "" 0 "" "" "EX_tetdece1crn[e]" -"MAR04967" "" "FAOXC101C8m" "" "" "" "FAOXC101C8m" "" "" "" "" 0 "" "" "FAOXC101C8m" "MAR04968" "" "FAOXC101C8x" "" "" "" "FAOXC101C8x" "" "" "" "" 0 "" "" "FAOXC101C8x" -"MAR04970" "" "FAOXC102C101m" "" "" "" "FAOXC102C101m;HMR_3422" "" "HMR_3422" "RCR12667" "" 0 "" "" "FAOXC102C101m;HMR_3422;MAR03422" -"MAR04974" "" "FAOXC102C101x" "" "" "" "FAOXC102C101x" "" "" "" "" 0 "" "" "FAOXC102C101x" -"MAR04978" "" "FAOXC102C103m" "" "" "" "FAOXC102C103m" "" "" "" "" 0 "" "" "FAOXC102C103m" +"MAR04970" "" "FAOXC102C101m" "" "" "" "FAOXC102C101m;HMR_3422" "" "HMR_3422" "RCR12667" "" 0 "" "" "FAOXC102C101m;HMR_3422;MAR03422;MAR03296" +"MAR04974" "" "FAOXC102C101x" "" "" "" "FAOXC102C101x" "" "" "" "" 0 "" "" "FAOXC102C101x;MAR03322" +"MAR04978" "" "FAOXC102C103m;HMR_3426" "" "" "" "FAOXC102C103m;HMR_3426" "" "HMR_3426" "RCR12671" "" 0 "" "" "FAOXC102C103m;HMR_3426;MAR03426" "MAR04981" "" "FAOXC102C103x" "" "" "" "FAOXC102C103x" "" "" "" "" 0 "" "" "FAOXC102C103x" -"MAR04984" "" "FAOXC102C81m" "" "" "" "FAOXC102C81m" "" "" "" "" 0 "" "" "FAOXC102C81m" +"MAR04984" "" "FAOXC102C81m;HMR_3426" "" "" "" "FAOXC102C81m;HMR_3426" "" "HMR_3426" "RCR12671" "" 0 "" "" "FAOXC102C81m;HMR_3426;MAR03426" "MAR04987" "" "FAOXC102C81x" "" "" "" "FAOXC102C81x" "" "" "" "" 0 "" "" "FAOXC102C81x" -"MAR04988" "" "FAOXC102m" "" "" "" "FAOXC102m" "" "" "" "" 0 "" "" "FAOXC102m" +"MAR04988" "" "FAOXC102m;HMR_3426" "" "" "" "FAOXC102m;HMR_3426" "" "HMR_3426" "RCR12671" "" 0 "" "" "FAOXC102m;HMR_3426;MAR03426" "MAR04991" "" "FAOXC102x" "" "" "" "FAOXC102x" "" "" "" "" 0 "" "" "FAOXC102x" -"MAR05001" "" "FAOXC103C102m" "" "" "" "FAOXC103C102m" "" "" "" "" 0 "" "" "FAOXC103C102m" +"MAR05001" "" "FAOXC103C102m;HMR_3426" "" "" "" "FAOXC103C102m;HMR_3426" "" "HMR_3426" "RCR12671" "" 0 "" "" "FAOXC103C102m;HMR_3426;MAR03426" "MAR05017" "" "FAOXC103C102x" "" "" "" "FAOXC103C102x" "" "" "" "" 0 "" "" "FAOXC103C102x" -"MAR05019" "" "FAOXC10C10OHm" "" "" "" "FAOXC10C10OHm" "" "" "" "" 0 "" "" "FAOXC10C10OHm" -"MAR05024" "" "FAOXC10080m" "" "" "" "FAOXC10C8m" "MNXR99262" "" "" "" 0 "" "" "FAOXC10C8m" "MAR05025" "" "FAOXC10080x" "" "" "" "FAOXC10C8x" "MNXR99263" "" "" "" 0 "" "" "FAOXC10C8x" "MAR05026" "" "FAOXC10DCC8DCx" "" "" "" "FAOXC10DCC8DCx" "" "" "" "" 0 "" "" "FAOXC10DCC8DCx" "MAR05028" "" "FAOXC11BRC9BRx" "" "" "" "FAOXC11BRC9BRx" "" "" "" "" 0 "" "" "FAOXC11BRC9BRx" @@ -9245,9 +9234,9 @@ rxns rxnKEGGID rxnBiGGID rxnEHMNID rxnHepatoNET1ID rxnREACTOMEID rxnRecon3DID rx "MAR05072" "" "FAOXC122C101m" "" "" "" "FAOXC122C101m;HMR_3422" "" "HMR_3422" "RCR12667" "" 0 "" "" "FAOXC122C101m;HMR_3422;MAR03422" "MAR05075" "" "FAOXC122m" "" "" "" "FAOXC122m;HMR_3422" "" "HMR_3422" "RCR12667" "" 0 "" "" "FAOXC122m;HMR_3422;MAR03422" "MAR05081" "" "FAOXC122x" "" "" "" "FAOXC122x" "" "" "" "" 0 "" "" "FAOXC122x" -"MAR05083" "" "FAOXC123C102m" "" "" "" "FAOXC123C102m" "" "" "" "" 0 "" "" "FAOXC123C102m" +"MAR05083" "" "FAOXC123C102m;HMR_3426" "" "" "" "FAOXC123C102;HMR_3426m" "" "HMR_3426" "RCR12671" "" 0 "" "" "FAOXC123C102m;HMR_3426;MAR03426" "MAR05086" "" "FAOXC123C102x" "" "" "" "FAOXC123C102x" "" "" "" "" 0 "" "" "FAOXC123C102x" -"MAR05090" "" "FAOXC123m" "" "" "" "FAOXC123m" "" "" "" "" 0 "" "" "FAOXC123m" +"MAR05090" "" "FAOXC123m;HMR_3426" "" "" "" "FAOXC123m;HMR_3426" "" "HMR_3426" "RCR12671" "" 0 "" "" "FAOXC123m;HMR_3426;MAR03426" "MAR05093" "" "FAOXC123x" "" "" "" "FAOXC123x" "" "" "" "" 0 "" "" "FAOXC123x" "MAR05095" "" "FAOXC120100m" "" "" "" "FAOXC12C10m" "MNXR99273" "" "" "" 0 "" "" "FAOXC12C10m" "MAR05097" "" "FAOXC120100x" "" "" "" "FAOXC12C10x" "MNXR99274" "" "" "" 0 "" "" "FAOXC12C10x" @@ -9264,7 +9253,7 @@ rxns rxnKEGGID rxnBiGGID rxnEHMNID rxnHepatoNET1ID rxnREACTOMEID rxnRecon3DID rx "MAR05123" "" "FAOXC142C122m" "" "" "" "FAOXC142C122m;HMR_3422" "" "HMR_3422" "RCR12667" "" 0 "" "" "FAOXC142C122m;HMR_3422;MAR03422" "MAR05175" "" "FAOXC142C122x" "" "" "" "FAOXC142C122x" "" "" "" "" 0 "" "" "FAOXC142C122x" "MAR05176" "" "FAOXC142C142OHm" "" "" "" "FAOXC142C142OHm" "" "" "" "" 0 "" "" "FAOXC142C142OHm" -"MAR05177" "" "FAOXC143C123m" "" "" "" "FAOXC143C123m" "" "" "" "" 0 "" "" "FAOXC143C123m" +"MAR05177" "" "FAOXC143C123m;HMR_3426" "" "" "" "FAOXC143C123m;HMR_3426" "" "HMR_3426" "RCR12671" "" 0 "" "" "FAOXC143C123m;HMR_3426;MAR03426" "MAR05178" "" "FAOXC143C123x" "" "" "" "FAOXC143C123x" "" "" "" "" 0 "" "" "FAOXC143C123x" "MAR05179" "" "FAOXC140120m" "" "" "" "FAOXC14C12m" "MNXR99282" "" "" "" 0 "" "" "FAOXC14C12m" "MAR05180" "" "FAOXC140120x" "" "" "" "FAOXC14C12x" "MNXR99283" "" "" "" 0 "" "" "FAOXC14C12x" @@ -9281,7 +9270,7 @@ rxns rxnKEGGID rxnBiGGID rxnEHMNID rxnHepatoNET1ID rxnREACTOMEID rxnRecon3DID rx "MAR05191" "" "FAOXC162C142m" "" "" "" "FAOXC162C142m" "" "" "" "" 0 "" "" "FAOXC162C142m" "MAR05192" "" "FAOXC162C162OHm" "" "" "" "FAOXC162C162OHm" "" "" "" "" 0 "" "" "FAOXC162C162OHm" "MAR05193" "" "FAOXC163C142x" "" "" "" "FAOXC163C142x" "" "" "" "" 0 "" "" "FAOXC163C142x" -"MAR05194" "" "FAOXC163C143m" "" "" "" "FAOXC163C143m" "" "" "" "" 0 "" "" "FAOXC163C143m" +"MAR05194" "" "FAOXC163C143m;HMR_3426" "" "" "" "FAOXC163C143m;HMR_3426" "" "HMR_3426" "RCR12671" "" 0 "" "" "FAOXC163C143m;HMR_3426;MAR03426" "MAR05195" "" "FAOXC163C164Gm" "" "" "" "FAOXC163C164Gm;HMR_3422" "" "HMR_3422" "RCR12667" "" 0 "" "" "FAOXC163C164Gm;HMR_3422;MAR03422" "MAR05196" "" "FAOXC163C164x" "" "" "" "FAOXC163C164x" "" "" "" "" 0 "" "" "FAOXC163C164x" "MAR05208" "" "FAOXC163GC142m" "" "" "" "FAOXC163GC142m;HMR_3422" "" "HMR_3422" "RCR12667" "" 0 "" "" "FAOXC163GC142m;HMR_3422;MAR03422" @@ -9310,7 +9299,7 @@ rxns rxnKEGGID rxnBiGGID rxnEHMNID rxnHepatoNET1ID rxnREACTOMEID rxnRecon3DID rx "MAR05356" "" "FAOXC182C162m" "" "" "" "FAOXC182C162m" "" "" "" "" 0 "" "" "FAOXC182C162m" "MAR05357" "" "FAOXC182C182OHm" "" "" "" "FAOXC182C182OHm" "" "" "" "" 0 "" "" "FAOXC182C182OHm" "MAR05358" "" "FAOXC183C163Gm" "" "" "" "FAOXC183C163Gm" "" "" "" "" 0 "" "" "FAOXC183C163Gm" -"MAR05359" "" "FAOXC183C163m" "" "" "" "FAOXC183C163m" "" "" "" "" 0 "" "" "FAOXC183C163m" +"MAR05359" "" "FAOXC183C163m;HMR_3426" "" "" "" "FAOXC183C163m;HMR_3426" "" "HMR_3426" "RCR12671" "" 0 "" "" "FAOXC183C163m;HMR_3426;MAR03426" "MAR05360" "" "FAOXC184C163m" "" "" "" "FAOXC184C163m;HMR_3422" "" "HMR_3422" "RCR12667" "" 0 "" "" "FAOXC184C163m;HMR_3422;MAR03422" "MAR05364" "" "FAOXC184C163x" "" "" "" "FAOXC184C163x" "" "" "" "" 0 "" "" "FAOXC184C163x" "MAR05365" "" "FAOXC184C164m" "" "" "" "FAOXC184C164m" "" "" "" "" 0 "" "" "FAOXC184C164m" @@ -9343,23 +9332,19 @@ rxns rxnKEGGID rxnBiGGID rxnEHMNID rxnHepatoNET1ID rxnREACTOMEID rxnRecon3DID rx "MAR05427" "" "FAOXC22OHC22r" "" "" "" "FAOXC22OHC22r" "" "" "" "" 0 "" "" "FAOXC22OHC22r" "MAR05428" "" "FAOXC241C221x" "" "" "" "FAOXC241C221x" "" "" "" "" 0 "" "" "FAOXC241C221x" "MAR05431" "" "FAOXC24C22x" "" "" "" "FAOXC24C22x" "" "" "" "" 0 "" "" "FAOXC24C22x" -"MAR05449" "" "FAOXC4020m" "" "" "" "FAOXC4C2m" "MNXR99368" "" "" "" 0 "" "" "FAOXC4C2m" "MAR05456" "" "FAOXC4C4DCc" "" "" "" "FAOXC4C4DCc" "" "" "" "" 0 "" "" "FAOXC4C4DCc" "MAR05988" "" "FAOXC5C3x" "" "" "" "FAOXC5C3x" "" "" "" "" 0 "" "" "FAOXC5C3x" "MAR05991" "" "FAOXC5C5DCc" "" "" "" "FAOXC5C5DCc" "" "" "" "" 0 "" "" "FAOXC5C5DCc" "MAR05999" "" "FAOXC5C5OHm" "" "" "" "FAOXC5C5OHm" "" "" "" "" 0 "RHEA:31081" "RHEA:31079" "FAOXC5C5OHm" "MAR06278" "" "FAOXC5OHc" "" "" "" "FAOXC5OHc" "" "" "" "" 0 "" "" "FAOXC5OHc" -"MAR06279" "" "FAOXC61C4m" "" "" "" "FAOXC61C4m" "" "" "" "" 0 "" "" "FAOXC61C4m" "MAR06280" "" "FAOXC61C4x" "" "" "" "FAOXC61C4x" "" "" "" "" 0 "" "" "FAOXC61C4x" -"MAR06281" "" "FAOXC61m" "" "" "" "FAOXC61m" "" "" "" "" 0 "" "" "FAOXC61m" +"MAR06281" "" "FAOXC61m;HMR_3426" "" "" "" "FAOXC61m;HMR_3426" "" "HMR_3426" "RCR12671" "" 0 "" "" "FAOXC61m;HMR_3426;MAR03426" "MAR06282" "" "FAOXC61x" "" "" "" "FAOXC61x" "" "" "" "" 0 "" "" "FAOXC61x" -"MAR06283" "" "FAOXC6C4m" "" "" "" "FAOXC6C4m" "" "" "" "" 0 "" "" "FAOXC6C4m" "MAR06284" "" "FAOXC6C4x" "" "" "" "FAOXC6C4x" "" "" "" "" 0 "" "" "FAOXC6C4x" "MAR06285" "" "FAOXC6DCC4DCx" "" "" "" "FAOXC6DCC4DCx" "" "" "" "" 0 "" "" "FAOXC6DCC4DCx" "MAR06319" "" "FAOXC7C5m" "" "" "" "FAOXC7C5m" "" "" "" "" 0 "" "" "FAOXC7C5m" -"MAR06320" "" "FAOXC81C61m" "" "" "" "FAOXC81C61m" "" "" "" "" 0 "" "" "FAOXC81C61m" +"MAR06320" "" "FAOXC81C61m;HMR_3426" "" "" "" "FAOXC81C61m;HMR_3426" "" "HMR_3426" "RCR12671" "" 0 "" "" "FAOXC81C61m;HMR_3426;MAR03426" "MAR06322" "" "FAOXC81C61x" "" "" "" "FAOXC81C61x" "" "" "" "" 0 "" "" "FAOXC81C61x" -"MAR06329" "" "FAOXC8C6m" "" "" "" "FAOXC8C6m" "" "" "" "" 0 "" "" "FAOXC8C6m" "MAR06344" "" "FAOXC8C6x" "" "" "" "FAOXC8C6x" "" "" "" "" 0 "" "" "FAOXC8C6x" "MAR06345" "" "FAOXC8DCC6DCx" "" "" "" "FAOXC8DCC6DCx" "" "" "" "" 0 "" "" "FAOXC8DCC6DCx" "MAR06346" "" "" "" "" "" "FAOXC9BRC7BRm" "" "" "" "" 0 "" "" "FAOXC9BRC7BRm"