diff --git a/model/Human-GEM.yml b/model/Human-GEM.yml
index a43481da..1a313d79 100644
--- a/model/Human-GEM.yml
+++ b/model/Human-GEM.yml
@@ -74296,9 +74296,9 @@
       - name: "(S)-dihydroorotate:NAD+ oxidoreductase"
       - metabolites: !!omap
           - MAM00180c: -1
+          - MAM01828c: -1
           - MAM02659c: 1
-          - MAM03102m: 1
-          - MAM03103m: -1
+          - MAM20019c: 1
       - lower_bound: -1000
       - upper_bound: 1000
       - gene_reaction_rule: "ENSG00000102967"
@@ -305329,6 +305329,24 @@
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
+    - !!omap
+      - id: "MAR20167"
+      - name: "MAR20167"
+      - metabolites: !!omap
+          - MAM01828c: 1
+          - MAM03102m: 1
+          - MAM03103m: -1
+          - MAM20019c: -1
+      - lower_bound: -1000
+      - upper_bound: 1000
+      - gene_reaction_rule: "ENSG00000102967"
+      - rxnNotes: ""
+      - rxnFrom: ""
+      - eccodes: ""
+      - references: "PMID:34428349"
+      - subsystem:
+          - "Miscellaneous"
+      - confidence_score: 0
 - genes:
     - !!omap
       - id: "ENSG00000000419"
diff --git a/model/reactions.tsv b/model/reactions.tsv
index 5de1d8ae..01a33724 100644
--- a/model/reactions.tsv
+++ b/model/reactions.tsv
@@ -12997,3 +12997,4 @@ rxns	rxnKEGGID	rxnBiGGID	rxnEHMNID	rxnHepatoNET1ID	rxnREACTOMEID	rxnRecon3DID	rx
 "MAR20164"	""	""	""	""	""	""	""	""	""	""	0	""	""	""
 "MAR20165"	""	""	""	""	""	""	""	""	""	""	0	""	""	""
 "MAR20166"	""	""	""	""	""	""	""	""	""	""	0	""	""	""
+"MAR20167"	""	""	""	""	""	""	""	""	""	""	0	""	""	""