diff --git a/.github/workflows/commentsFromTests.md b/.github/workflows/commentsFromTests.md
deleted file mode 100644
index dd2ba900..00000000
--- a/.github/workflows/commentsFromTests.md
+++ /dev/null
@@ -1,7 +0,0 @@
-This PR has been [automatically tested with GH Actions](https://github.com/SysBioChalmers/Human-GEM/actions/runs/{GH_ACTION_RUN}). Here is the output of the gene essentiality test:
-
-<pre>
-{TEST_RESULTS}
-</pre>
-
-> _Note: In the case of multiple test runs, this post will be edited._
diff --git a/model/Human-GEM.yml b/model/Human-GEM.yml
index e6e2ecff..568b3f1d 100644
--- a/model/Human-GEM.yml
+++ b/model/Human-GEM.yml
@@ -68303,7 +68303,7 @@
           - MAM02450e: -1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000092529 or ENSG00000171298 or ENSG00000214013 or ENSG00000257335"
+      - gene_reaction_rule: "ENSG00000171298 or ENSG00000214013 or ENSG00000257335"
       - rxnNotes: ""
       - rxnFrom: "HMRdatabase"
       - eccodes: "3.2.1.20"
@@ -68340,7 +68340,7 @@
           - MAM03039e: -1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000118094 or ENSG00000142102"
+      - gene_reaction_rule: "ENSG00000118094"
       - rxnNotes: ""
       - rxnFrom: "HMRdatabase"
       - eccodes: "3.2.1.28"
@@ -68500,7 +68500,7 @@
           - MAM02448c: 1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000120563 or ENSG00000174876 or ENSG00000187733 or ENSG00000237763 or ENSG00000240038 or ENSG00000243480"
+      - gene_reaction_rule: "ENSG00000120563 or ENSG00000240038 or ENSG00000243480"
       - rxnNotes: ""
       - rxnFrom: "HMRdatabase"
       - eccodes: "3.2.1.1"
@@ -68572,7 +68572,7 @@
           - MAM02447c: 1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000120563 or ENSG00000174876 or ENSG00000187733 or ENSG00000237763 or ENSG00000240038 or ENSG00000243480"
+      - gene_reaction_rule: "ENSG00000120563 or ENSG00000240038 or ENSG00000243480"
       - rxnNotes: ""
       - rxnFrom: "HMRdatabase"
       - eccodes: "3.2.1.1"
@@ -68608,7 +68608,7 @@
           - MAM02449c: 1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000120563 or ENSG00000174876 or ENSG00000187733 or ENSG00000237763 or ENSG00000240038 or ENSG00000243480"
+      - gene_reaction_rule: "ENSG00000120563 or ENSG00000240038 or ENSG00000243480"
       - rxnNotes: ""
       - rxnFrom: "HMRdatabase"
       - eccodes: "3.2.1.1"
@@ -68644,7 +68644,7 @@
           - MAM02451c: 1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000120563 or ENSG00000174876 or ENSG00000187733 or ENSG00000237763 or ENSG00000240038 or ENSG00000243480"
+      - gene_reaction_rule: "ENSG00000120563 or ENSG00000240038 or ENSG00000243480"
       - rxnNotes: ""
       - rxnFrom: "HMRdatabase"
       - eccodes: "3.2.1.1"
@@ -68680,7 +68680,7 @@
           - MAM02452c: 1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000120563 or ENSG00000174876 or ENSG00000187733 or ENSG00000237763 or ENSG00000240038 or ENSG00000243480"
+      - gene_reaction_rule: "ENSG00000120563 or ENSG00000240038 or ENSG00000243480"
       - rxnNotes: ""
       - rxnFrom: "HMRdatabase"
       - eccodes: "3.2.1.1"
@@ -68770,7 +68770,7 @@
           - MAM02452c: -1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000120563 or ENSG00000174876 or ENSG00000187733 or ENSG00000237763 or ENSG00000240038 or ENSG00000243480"
+      - gene_reaction_rule: "ENSG00000120563 or ENSG00000240038 or ENSG00000243480"
       - rxnNotes: ""
       - rxnFrom: "HMRdatabase"
       - eccodes: "3.2.1.1"
@@ -68787,7 +68787,7 @@
           - MAM02450c: -1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000120563 or ENSG00000174876 or ENSG00000187733 or ENSG00000237763 or ENSG00000240038 or ENSG00000243480"
+      - gene_reaction_rule: "ENSG00000120563 or ENSG00000240038 or ENSG00000243480"
       - rxnNotes: ""
       - rxnFrom: "HMRdatabase"
       - eccodes: "3.2.1.1"
@@ -77405,7 +77405,7 @@
           - MAM02943m: 1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000134333"
+      - gene_reaction_rule: ""
       - rxnNotes: ""
       - rxnFrom: "HMRdatabase"
       - eccodes: "1.2.1.16"
@@ -80744,7 +80744,7 @@
           - MAM03124c: -1
       - lower_bound: -1000
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000006695 or ENSG00000054267 or ENSG00000117682 or ENSG00000120942 or ENSG00000183665"
+      - gene_reaction_rule: "ENSG00000054267 or ENSG00000117682 or ENSG00000120942 or ENSG00000183665"
       - rxnNotes: ""
       - rxnFrom: "HMRdatabase"
       - eccodes: "2.5.1.-"
@@ -85711,7 +85711,7 @@
           - MAM02555c: -1
       - lower_bound: -1000
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000181652 or ENSG00000184470 or ENSG00000197763 or ENSG00000198431"
+      - gene_reaction_rule: "ENSG00000184470 or ENSG00000197763 or ENSG00000198431"
       - rxnNotes: ""
       - rxnFrom: "HMRdatabase"
       - eccodes: "1.8.1.9"
@@ -86410,7 +86410,7 @@
           - MAM02041e: -1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000116157 or ENSG00000117450 or ENSG00000117592 or ENSG00000126432 or ENSG00000164294 or ENSG00000165672 or ENSG00000167468 or ENSG00000167815 or ENSG00000176153 or ENSG00000198704 or ENSG00000211445 or ENSG00000224586 or ENSG00000233276"
+      - gene_reaction_rule: "ENSG00000116157 or ENSG00000117450 or ENSG00000117592 or ENSG00000126432 or ENSG00000164294 or ENSG00000167468 or ENSG00000167815 or ENSG00000176153 or ENSG00000198704 or ENSG00000211445 or ENSG00000224586 or ENSG00000233276"
       - rxnNotes: ""
       - rxnFrom: "HMRdatabase"
       - eccodes: "1.11.1.9;1.11.1.15"
@@ -86668,7 +86668,7 @@
           - MAM02039c: -1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000128683 or ENSG00000136750"
+      - gene_reaction_rule: "ENSG00000136750"
       - rxnNotes: ""
       - rxnFrom: "HMRdatabase"
       - eccodes: "4.1.1.11;4.1.1.15"
@@ -86882,7 +86882,7 @@
           - MAM02885c: -1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000138801 or ENSG00000198682"
+      - gene_reaction_rule: ""
       - rxnNotes: ""
       - rxnFrom: "HMRdatabase"
       - eccodes: "2.7.7.4"
@@ -88067,7 +88067,7 @@
           - MAM02527c: 1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000111261 or ENSG00000133048 or ENSG00000133063 or ENSG00000134216"
+      - gene_reaction_rule: "ENSG00000111261 or ENSG00000133063 or ENSG00000134216"
       - rxnNotes: ""
       - rxnFrom: "HMRdatabase"
       - eccodes: "3.2.1.14"
@@ -93247,7 +93247,7 @@
           - MAM03135c: 28
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000165996 or ENSG00000206527"
+      - gene_reaction_rule: ""
       - rxnNotes: ""
       - rxnFrom: "HMRdatabase"
       - eccodes: "4.2.1.134"
@@ -93535,7 +93535,7 @@
           - MAM02751c: 1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000104331 or ENSG00000162813"
+      - gene_reaction_rule: "ENSG00000162813"
       - rxnNotes: ""
       - rxnFrom: "HMRdatabase"
       - eccodes: "3.1.3.7"
@@ -93611,7 +93611,7 @@
           - MAM02877c: -1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000006534 or ENSG00000108602 or ENSG00000132746 or ENSG00000184254"
+      - gene_reaction_rule: "ENSG00000006534 or ENSG00000132746 or ENSG00000184254"
       - rxnNotes: ""
       - rxnFrom: "HMRdatabase"
       - eccodes: "1.2.1.5"
@@ -140094,7 +140094,7 @@
           - MAM02946l: 1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000049860 or ENSG00000068001 or ENSG00000106302 or ENSG00000106304 or ENSG00000114378 or ENSG00000169660 or ENSG00000186792 or ENSG00000213614"
+      - gene_reaction_rule: "ENSG00000049860 or ENSG00000068001 or ENSG00000106302 or ENSG00000114378 or ENSG00000169660 or ENSG00000186792 or ENSG00000213614"
       - rxnNotes: ""
       - rxnFrom: "HMRdatabase"
       - eccodes: "3.2.1.35;3.2.1.52"
@@ -140337,7 +140337,7 @@
           - MAM02946l: 1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000064601 and ENSG00000141012 and ENSG00000170266 and ENSG00000204386"
+      - gene_reaction_rule: "ENSG00000064601 and ENSG00000141012 and ENSG00000170266"
       - rxnNotes: ""
       - rxnFrom: "HMRdatabase"
       - eccodes: "3.1.6.4;3.2.1.18;3.2.1.23;3.4.16.5"
@@ -140412,7 +140412,7 @@
           - MAM02946l: 1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000064601 and ENSG00000141012 and ENSG00000170266 and ENSG00000204386"
+      - gene_reaction_rule: "ENSG00000064601 and ENSG00000141012 and ENSG00000170266"
       - rxnNotes: ""
       - rxnFrom: "HMRdatabase"
       - eccodes: "3.1.6.4;3.2.1.18;3.2.1.23;3.4.16.5"
@@ -140508,7 +140508,7 @@
           - MAM02946l: 1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000064601 and ENSG00000141012 and ENSG00000170266 and ENSG00000204386"
+      - gene_reaction_rule: "ENSG00000064601 and ENSG00000141012 and ENSG00000170266"
       - rxnNotes: ""
       - rxnFrom: "HMRdatabase"
       - eccodes: "3.1.6.4;3.2.1.18;3.2.1.23;3.4.16.5"
@@ -140602,7 +140602,7 @@
           - MAM02946l: 1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000064601 and ENSG00000141012 and ENSG00000170266 and ENSG00000204386"
+      - gene_reaction_rule: "ENSG00000064601 and ENSG00000141012 and ENSG00000170266"
       - rxnNotes: ""
       - rxnFrom: "HMRdatabase"
       - eccodes: "3.1.6.4;3.2.1.18;3.2.1.23;3.4.16.5"
@@ -140735,7 +140735,7 @@
           - MAM02946l: 1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000064601 and ENSG00000141012 and ENSG00000170266 and ENSG00000204386"
+      - gene_reaction_rule: "ENSG00000064601 and ENSG00000141012 and ENSG00000170266"
       - rxnNotes: ""
       - rxnFrom: "HMRdatabase"
       - eccodes: "3.1.6.4;3.2.1.18;3.2.1.23;3.4.16.5"
@@ -142090,7 +142090,7 @@
           - MAM02682g: -1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000135702 or ENSG00000140835 or ENSG00000175040 or ENSG00000183196"
+      - gene_reaction_rule: "ENSG00000140835 or ENSG00000175040 or ENSG00000183196"
       - rxnNotes: ""
       - rxnFrom: "HMRdatabase"
       - eccodes: "2.8.2.-"
@@ -159340,7 +159340,7 @@
           - MAM02630c: -1
       - lower_bound: -1000
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000021461 or ENSG00000106258 or ENSG00000108242 or ENSG00000138061 or ENSG00000138109 or ENSG00000138115 or ENSG00000140465 or ENSG00000160868 or ENSG00000160870 or ENSG00000165841"
+      - gene_reaction_rule: "ENSG00000021461 or ENSG00000106258 or ENSG00000138061 or ENSG00000138109 or ENSG00000138115 or ENSG00000140465 or ENSG00000160868 or ENSG00000160870 or ENSG00000165841"
       - rxnNotes: ""
       - rxnFrom: "HMRdatabase"
       - eccodes: "1.14.14.1"
@@ -159382,7 +159382,7 @@
           - MAM02630c: -1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000021461 or ENSG00000106258 or ENSG00000108242 or ENSG00000138061 or ENSG00000138109 or ENSG00000138115 or ENSG00000140465 or ENSG00000160868 or ENSG00000160870 or ENSG00000165841"
+      - gene_reaction_rule: "ENSG00000021461 or ENSG00000106258 or ENSG00000138061 or ENSG00000138109 or ENSG00000138115 or ENSG00000140465 or ENSG00000160868 or ENSG00000160870 or ENSG00000165841"
       - rxnNotes: ""
       - rxnFrom: "HMRdatabase"
       - eccodes: "1.14.14.1"
@@ -159695,7 +159695,7 @@
           - MAM03043c: 1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000147576 or ENSG00000172955 or ENSG00000187758 or ENSG00000196344 or ENSG00000196616 or ENSG00000197894 or ENSG00000198099 or ENSG00000248144"
+      - gene_reaction_rule: "ENSG00000172955 or ENSG00000187758 or ENSG00000196344 or ENSG00000197894 or ENSG00000198099 or ENSG00000248144"
       - rxnNotes: ""
       - rxnFrom: "HMRdatabase"
       - eccodes: "1.1.1.1"
@@ -159971,7 +159971,7 @@
           - MAM02630c: -1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000021461 or ENSG00000106258 or ENSG00000108242 or ENSG00000138061 or ENSG00000138109 or ENSG00000138115 or ENSG00000140465 or ENSG00000160868 or ENSG00000160870 or ENSG00000165841"
+      - gene_reaction_rule: "ENSG00000021461 or ENSG00000106258 or ENSG00000138061 or ENSG00000138109 or ENSG00000138115 or ENSG00000140465 or ENSG00000160868 or ENSG00000160870 or ENSG00000165841"
       - rxnNotes: ""
       - rxnFrom: "HMRdatabase"
       - eccodes: "1.14.14.1"
@@ -160084,7 +160084,7 @@
           - MAM02555c: -1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000104808 or ENSG00000117594 or ENSG00000151632 or ENSG00000159228 or ENSG00000159231 or ENSG00000187134 or ENSG00000196139 or ENSG00000198610"
+      - gene_reaction_rule: "ENSG00000104808 or ENSG00000151632 or ENSG00000159228 or ENSG00000159231 or ENSG00000187134 or ENSG00000196139 or ENSG00000198610"
       - rxnNotes: ""
       - rxnFrom: "HMRdatabase"
       - eccodes: "1.1.1.146;1.1.1.184;1.3.1.20"
@@ -160786,7 +160786,7 @@
           - MAM02630c: -1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000021461 or ENSG00000106258 or ENSG00000108242 or ENSG00000138061 or ENSG00000138109 or ENSG00000138115 or ENSG00000140465 or ENSG00000160868 or ENSG00000160870 or ENSG00000165841"
+      - gene_reaction_rule: "ENSG00000021461 or ENSG00000106258 or ENSG00000138061 or ENSG00000138109 or ENSG00000138115 or ENSG00000140465 or ENSG00000160868 or ENSG00000160870 or ENSG00000165841"
       - rxnNotes: ""
       - rxnFrom: "HMRdatabase"
       - eccodes: "1.14.14.1"
@@ -161269,7 +161269,7 @@
           - MAM02156c: -1
       - lower_bound: -1000
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000117592 or ENSG00000121053 or ENSG00000130508 or ENSG00000167419"
+      - gene_reaction_rule: "ENSG00000117592 or ENSG00000121053 or ENSG00000167419"
       - rxnNotes: ""
       - rxnFrom: "HMRdatabase"
       - eccodes: "1.11.1.7"
@@ -161288,7 +161288,7 @@
           - MAM02591c: 1
       - lower_bound: -1000
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000117592 or ENSG00000121053 or ENSG00000130508 or ENSG00000167419"
+      - gene_reaction_rule: "ENSG00000121053 or ENSG00000130508 or ENSG00000167419"
       - rxnNotes: ""
       - rxnFrom: "HMRdatabase"
       - eccodes: "1.11.1.7"
@@ -161306,7 +161306,7 @@
           - MAM02754e: 1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000006534 or ENSG00000014257 or ENSG00000102575 or ENSG00000134575 or ENSG00000142513 or ENSG00000155893 or ENSG00000162551 or ENSG00000162836 or ENSG00000163283 or ENSG00000163286 or ENSG00000163295 or ENSG00000184254"
+      - gene_reaction_rule: "ENSG00000014257 or ENSG00000102575 or ENSG00000134575 or ENSG00000142513 or ENSG00000155893 or ENSG00000162551 or ENSG00000162836 or ENSG00000163283 or ENSG00000163286 or ENSG00000163295"
       - rxnNotes: ""
       - rxnFrom: "HMRdatabase"
       - eccodes: "3.1.3.1;3.1.3.2;3.1.3.41"
@@ -218065,7 +218065,7 @@
           - MAM03622e: 1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "(ENSG00000021488 and ENSG00000138079) or ENSG00000168003 or ENSG00000174876 or ENSG00000187733 or ENSG00000237763 or ENSG00000240038 or ENSG00000243480"
+      - gene_reaction_rule: "ENSG00000168003 or ENSG00000174876 or ENSG00000187733 or ENSG00000237763 or ENSG00000240038 or ENSG00000243480"
       - rxnNotes: ""
       - rxnFrom: "Recon3D"
       - eccodes: "3.2.1.1"
@@ -218356,7 +218356,7 @@
           - MAM02553m: 1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000111275 or ENSG00000137124 or ENSG00000159423"
+      - gene_reaction_rule: "ENSG00000111275 or ENSG00000137124"
       - rxnNotes: ""
       - rxnFrom: "Recon3D"
       - eccodes: "1.5.1.12"
@@ -235455,7 +235455,7 @@
           - MAM03381r: 1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000021461 or ENSG00000100197 or ENSG00000106258 or ENSG00000108242 or ENSG00000130649 or ENSG00000134716 or ENSG00000137869 or ENSG00000138061 or ENSG00000138109 or ENSG00000138115 or ENSG00000140465 or ENSG00000140505 or ENSG00000142973 or ENSG00000160868 or ENSG00000160870 or ENSG00000167600 or ENSG00000171903 or ENSG00000186160 or ENSG00000186204 or ENSG00000186377 or ENSG00000186526 or ENSG00000197408 or ENSG00000197446 or ENSG00000197838 or ENSG00000198077 or ENSG00000255974"
+      - gene_reaction_rule: "ENSG00000021461 or ENSG00000100197 or ENSG00000106258 or ENSG00000108242 or ENSG00000130649 or ENSG00000134716 or ENSG00000138061 or ENSG00000138109 or ENSG00000138115 or ENSG00000140465 or ENSG00000140505 or ENSG00000142973 or ENSG00000160868 or ENSG00000160870 or ENSG00000167600 or ENSG00000171903 or ENSG00000186160 or ENSG00000186204 or ENSG00000186526 or ENSG00000197408 or ENSG00000197446 or ENSG00000197838 or ENSG00000198077 or ENSG00000255974"
       - rxnNotes: ""
       - rxnFrom: "Recon3D"
       - eccodes: "1.14.14.1"
@@ -235656,7 +235656,7 @@
           - MAM03386r: 1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000021461 or ENSG00000100197 or ENSG00000106258 or ENSG00000108242 or ENSG00000130649 or ENSG00000134716 or ENSG00000137869 or ENSG00000138061 or ENSG00000138109 or ENSG00000138115 or ENSG00000140465 or ENSG00000140505 or ENSG00000142973 or ENSG00000160868 or ENSG00000160870 or ENSG00000167600 or ENSG00000171903 or ENSG00000186160 or ENSG00000186204 or ENSG00000186377 or ENSG00000186526 or ENSG00000197408 or ENSG00000197446 or ENSG00000197838 or ENSG00000198077 or ENSG00000255974"
+      - gene_reaction_rule: "ENSG00000021461 or ENSG00000100197 or ENSG00000106258 or ENSG00000108242 or ENSG00000130649 or ENSG00000134716 or ENSG00000137869 or ENSG00000138061 or ENSG00000138109 or ENSG00000138115 or ENSG00000140465 or ENSG00000140505 or ENSG00000142973 or ENSG00000160868 or ENSG00000160870 or ENSG00000167600 or ENSG00000171903 or ENSG00000186204 or ENSG00000186526 or ENSG00000197408 or ENSG00000197446 or ENSG00000197838 or ENSG00000198077 or ENSG00000255974"
       - rxnNotes: ""
       - rxnFrom: "Recon3D"
       - eccodes: "1.14.14.1"
@@ -235749,7 +235749,7 @@
           - MAM03388r: 1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000021461 or ENSG00000100197 or ENSG00000106258 or ENSG00000108242 or ENSG00000130649 or ENSG00000134716 or ENSG00000137869 or ENSG00000138061 or ENSG00000138109 or ENSG00000138115 or ENSG00000140465 or ENSG00000140505 or ENSG00000142973 or ENSG00000160868 or ENSG00000160870 or ENSG00000167600 or ENSG00000171903 or ENSG00000186160 or ENSG00000186204 or ENSG00000186377 or ENSG00000186526 or ENSG00000197408 or ENSG00000197446 or ENSG00000197838 or ENSG00000198077 or ENSG00000255974"
+      - gene_reaction_rule: "ENSG00000021461 or ENSG00000100197 or ENSG00000106258 or ENSG00000130649 or ENSG00000134716 or ENSG00000137869 or ENSG00000138061 or ENSG00000138109 or ENSG00000138115 or ENSG00000140465 or ENSG00000140505 or ENSG00000142973 or ENSG00000160868 or ENSG00000160870 or ENSG00000167600 or ENSG00000171903 or ENSG00000186160 or ENSG00000186204 or ENSG00000186377 or ENSG00000186526 or ENSG00000197408 or ENSG00000197446 or ENSG00000197838 or ENSG00000198077 or ENSG00000255974"
       - rxnNotes: ""
       - rxnFrom: "Recon3D"
       - eccodes: "1.14.14.1"
@@ -305798,9 +305798,6 @@
     - !!omap
       - id: "ENSG00000092295"
       - name: "TGM1"
-    - !!omap
-      - id: "ENSG00000092529"
-      - name: "CAPN3"
     - !!omap
       - id: "ENSG00000092621"
       - name: "PHGDH"
@@ -311900,9 +311897,6 @@
     - !!omap
       - id: "ENSG00000181555"
       - name: "SETD2"
-    - !!omap
-      - id: "ENSG00000181652"
-      - name: "ATG9B"
     - !!omap
       - id: "ENSG00000181788"
       - name: "SIAH2"
diff --git a/model/genes.tsv b/model/genes.tsv
index 763bde13..73213a76 100644
--- a/model/genes.tsv
+++ b/model/genes.tsv
@@ -389,7 +389,6 @@ ENSG00000092068	"ENST00000339733;ENST00000316902;ENST00000397310;ENST00000422941
 ENSG00000092098	"ENST00000560875;ENST00000559308;ENST00000558634;ENST00000557878;ENST00000559533;ENST00000557991;ENST00000559438;ENST00000560071;ENST00000559275;ENST00000324103;ENST00000559882;ENST00000559260;ENST00000560342;ENST00000558907;ENST00000560787;ENST00000559583;ENST00000491351;ENST00000559071;ENST00000560754;ENST00000558452;ENST00000559449;ENST00000483895;ENST00000559719;ENST00000559491;ENST00000560631"	"ENSP00000454032;ENSP00000453471;ENSP00000454048;ENSP00000453423;ENSP00000453948;ENSP00000453574;ENSP00000315112;ENSP00000453645;ENSP00000453601;ENSP00000452972;ENSP00000499015;ENSP00000453595;ENSP00000454140;ENSP00000453672;ENSP00000452820"	Q96EP0	RNF31	55072	ring finger protein 31	"FLJ10111;FLJ23501;HOIP;Paul;ZIBRA"	Cytosol	"SwissProt;CellAtlas"
 ENSG00000092148	"ENST00000554882;ENST00000399332;ENST00000555843;ENST00000611816;ENST00000553700;ENST00000556281;ENST00000557695;ENST00000555311;ENST00000553957;ENST00000557321;ENST00000554027;ENST00000555915;ENST00000556004;ENST00000557369;ENST00000554850;ENST00000556224;ENST00000554471;ENST00000553616;ENST00000556474"	"ENSP00000451260;ENSP00000382269;ENSP00000484981;ENSP00000450697;ENSP00000451860;ENSP00000450920;ENSP00000452233;ENSP00000452015;ENSP00000479695"	Q9ULT8	HECTD1	25831	HECT domain E3 ubiquitin protein ligase 1	KIAA1131	Nucleus	CellAtlas
 ENSG00000092295	"ENST00000206765;ENST00000544573;ENST00000559669;ENST00000559136;ENST00000558074;ENST00000560443;ENST00000560478;ENST00000560226;ENST00000561067"	"ENSP00000206765;ENSP00000439446;ENSP00000453701;ENSP00000453337;ENSP00000453840;ENSP00000452822;ENSP00000453234;ENSP00000454070;ENSP00000452690"	P22735	TGM1	7051	transglutaminase 1	"ICR2;LI;LI1;TGASE;TGK"	Cytosol	DeepLoc2
-ENSG00000092529	"ENST00000349748;ENST00000397163;ENST00000357568;ENST00000638141;ENST00000673705;ENST00000673658;ENST00000673813;ENST00000397200;ENST00000569827;ENST00000673646;ENST00000567071;ENST00000673854;ENST00000674093;ENST00000569136;ENST00000673936;ENST00000673890;ENST00000674149;ENST00000673771;ENST00000337571;ENST00000673743;ENST00000673939;ENST00000674146;ENST00000674119;ENST00000674064;ENST00000673692;ENST00000565173;ENST00000674052;ENST00000561817;ENST00000674018;ENST00000397204;ENST00000673886;ENST00000674139;ENST00000673851;ENST00000673839;ENST00000673978;ENST00000673987;ENST00000673928;ENST00000674041;ENST00000565559;ENST00000673750;ENST00000674011;ENST00000674135;ENST00000674012;ENST00000565274;ENST00000674140;ENST00000564503;ENST00000673774;ENST00000673950;ENST00000466222;ENST00000673687;ENST00000674027;ENST00000674130;ENST00000562199;ENST00000673893;ENST00000673684;ENST00000568153;ENST00000567817;ENST00000356316;ENST00000318023"	"ENSP00000183936;ENSP00000380349;ENSP00000350181;ENSP00000501021;ENSP00000380384;ENSP00000454379;ENSP00000501007;ENSP00000456607;ENSP00000501303;ENSP00000455254;ENSP00000501189;ENSP00000501293;ENSP00000501112;ENSP00000501023;ENSP00000336840;ENSP00000500989;ENSP00000501129;ENSP00000501175;ENSP00000501217;ENSP00000501138;ENSP00000501057;ENSP00000456575;ENSP00000501271;ENSP00000380387;ENSP00000501155;ENSP00000501054;ENSP00000501142;ENSP00000501188;ENSP00000500976;ENSP00000501231;ENSP00000501099;ENSP00000500956;ENSP00000457878;ENSP00000501173;ENSP00000501171;ENSP00000501178;ENSP00000457759;ENSP00000457898;ENSP00000501034;ENSP00000500987;ENSP00000454937;ENSP00000456514;ENSP00000348667;ENSP00000326281"	P20807	CAPN3	825	calpain 3	"CANP3;LGMD2;LGMD2A;nCL-1;p94"	"Cytosol;Nucleus"	SwissProt
 ENSG00000092621	"ENST00000641597;ENST00000493622;ENST00000641720;ENST00000642041;ENST00000641947;ENST00000641213;ENST00000641074;ENST00000496756;ENST00000641115;ENST00000642021;ENST00000641491;ENST00000369409;ENST00000641023;ENST00000641513;ENST00000641573;ENST00000641587;ENST00000641570;ENST00000641891;ENST00000641375;ENST00000462324;ENST00000641371;ENST00000641272;ENST00000641247;ENST00000641756;ENST00000641711;ENST00000641927;ENST00000641314;ENST00000369407;ENST00000641811;ENST00000641847;ENST00000641455;ENST00000469443;ENST00000641939;ENST00000482968"	"ENSP00000493382;ENSP00000493433;ENSP00000492948;ENSP00000493415;ENSP00000492994;ENSP00000493079;ENSP00000493446;ENSP00000493264;ENSP00000493187;ENSP00000358417;ENSP00000493175;ENSP00000493398;ENSP00000493453;ENSP00000493213;ENSP00000493288;ENSP00000493089;ENSP00000493305;ENSP00000493432;ENSP00000492955;ENSP00000493147;ENSP00000493296"	O43175	PHGDH	26227	phosphoglycerate dehydrogenase	"PDG;PGDH;SERA"	"Cytosol;Nucleus"	CellAtlas
 ENSG00000092964	"ENST00000521913;ENST00000493789;ENST00000311151;ENST00000523027;ENST00000523690;ENST00000523093;ENST00000521983;ENST00000474808"	"ENSP00000427985;ENSP00000427954;ENSP00000309539;ENSP00000431117"	Q16555	DPYSL2	1808	dihydropyrimidinase like 2	"CRMP2;DHPRP2;DRP-2;DRP2"	Cytosol	"SwissProt;CellAtlas"
 ENSG00000093000	"ENST00000347635;ENST00000407019;ENST00000424634;ENST00000417702;ENST00000497960;ENST00000461437;ENST00000434760;ENST00000430547;ENST00000484186;ENST00000445721;ENST00000493456;ENST00000396096;ENST00000461194;ENST00000432340;ENST00000419387;ENST00000422489;ENST00000486184;ENST00000491860;ENST00000469163"	"ENSP00000345895;ENSP00000385555;ENSP00000415062;ENSP00000394450;ENSP00000388426;ENSP00000397960;ENSP00000398297;ENSP00000379403;ENSP00000400465;ENSP00000391987;ENSP00000416264"	Q9UKX7	NUP50	10762	nucleoporin 50	NPAP60L	Nucleus	"SwissProt;CellAtlas"
@@ -2407,7 +2406,6 @@ ENSG00000181192	"ENST00000263035;ENST00000437298;ENST00000465617;ENST00000415935
 ENSG00000181222	"ENST00000674977;ENST00000617998;ENST00000572844;ENST00000576952;ENST00000575547;ENST00000576114;ENST00000576718;ENST00000574158;ENST00000573603;ENST00000576553"	ENSP00000502190	A0A6Q8PGB0	POLR2A	5430	RNA polymerase II subunit A	"POLR2;POLRA;RPB1"	"Cytosol;Nucleus"	CellAtlas
 ENSG00000181523	"ENST00000575484;ENST00000571156;ENST00000572257;ENST00000326317;ENST00000575282;ENST00000573150;ENST00000576856;ENST00000570923;ENST00000576941;ENST00000574505;ENST00000572208;ENST00000571051;ENST00000576707;ENST00000570427;ENST00000571675;ENST00000575188;ENST00000571075"	"ENSP00000461827;ENSP00000314606;ENSP00000459280;ENSP00000460720;ENSP00000458200;ENSP00000461160;ENSP00000459708;ENSP00000461128;ENSP00000459765"	P51688	SGSH	6448	N-sulfoglucosamine sulfohydrolase	"HSS;MPS3A;SFMD"	Lysosome	SwissProt
 ENSG00000181555	"ENST00000431180;ENST00000330022;ENST00000409792;ENST00000445387;ENST00000479832;ENST00000492397;ENST00000638947;ENST00000484689;ENST00000412450"	"ENSP00000388349;ENSP00000332415;ENSP00000386759;ENSP00000411901;ENSP00000491413;ENSP00000416401"	Q9BYW2	SETD2	29072	SET domain containing 2, histone lysine methyltransferase	"FLJ23184;HIF-1;HYPB;KIAA1732;KMT3A"	"Nucleus;Cytosol"	"SwissProt;CellAtlas"
-ENSG00000181652	"ENST00000498521;ENST00000605952;ENST00000639579;ENST00000617967;ENST00000404733;ENST00000476282;ENST00000471797;ENST00000611177;ENST00000469530;ENST00000473409;ENST00000473134;ENST00000466157"	"ENSP00000475737;ENSP00000491504;ENSP00000479879"	Q674R7	ATG9B	285973	autophagy related 9B	"APG9L2;FLJ14885;NOS3AS;SONE"	Cytosol	SwissProt
 ENSG00000181788	"ENST00000312960;ENST00000482706;ENST00000472885"	"ENSP00000322457;ENSP00000417619"	O43255	SIAH2	6478	siah E3 ubiquitin protein ligase 2		"Nucleus;Cytosol"	"SwissProt;CellAtlas"
 ENSG00000181789	"ENST00000314797;ENST00000513965;ENST00000515725;ENST00000504350;ENST00000509208;ENST00000504547;ENST00000513410;ENST00000509889;ENST00000514478;ENST00000512034"	"ENSP00000325002;ENSP00000426457;ENSP00000422478;ENSP00000420916"	Q9Y678	COPG1	22820	COPI coat complex subunit gamma 1	COPG	"Golgi apparatus;Nucleus;Cytosol"	"SwissProt;CellAtlas"
 ENSG00000181804	"ENST00000316549;ENST00000483124;ENST00000474727;ENST00000474151;ENST00000498717"	"ENSP00000320246;ENSP00000419090;ENSP00000418627"	Q8IVB4	SLC9A9	285195	solute carrier family 9 member A9	"FLJ35613;NHE9"	"Cell membrane;Lysosome"	DeepLoc2