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reatine\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"grdp_c\",\n\"name\":\"geranyl_diphosphate\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"orot_c\",\n\"name\":\"orotate\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"2pg_c\",\n\"name\":\"2_phospho_D_glycerate\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"butACP_c\",\n\"name\":\"butyryl__acyl_carrier_protein_\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"4ampm_c\",\n\"name\":\"hydroxymethylpyrimidine_phosphate\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"dpcoa_c\",\n\"name\":\"dephospho_CoA\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"dhrdpin_c\",\n\"name\":\"3_4_dehydrorhodopin\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"2agpe180_c\",\n\"name\":\"2_octadecanoyl_sn_glycero_3_phosphoethanolamine\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"3ochd9ecoa_c\",\n\"name\":\"3_oxo_cis_hexadec_9_enoyl_CoA\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"23dhdp_c\",\n\"name\":\"dihydrodipicolinate\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"pmcoa_c\",\n\"name\":\"6_carboxyhexanoyl_CoA\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"valtrna_c\",\n\"name\":\"L_valyl_tRNA_Val_\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"succoa_c\",\n\"name\":\"succinyl_CoA\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"trnahis_c\",\n\"name\":\"tRNA_His_\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"polypi_c\",\n\"name\":\"polyphosphate\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"thf6glu_c\",\n\"name\":\"tetrahydropteroyl__gamma_Glu_6\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"focytc_c\",\n\"name\":\"reduced_cytochrome_c\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"dhpt_c\",\n\"name\":\"7_8_dihydropteroate\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"sorbnl_L_c\",\n\"name\":\"L_sorbosone_2_6_lactone\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"3dhq_c\",\n\"name\":\"3_dehydroquinate\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"fadh2_c\",\n\"name\":\"FADH2\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"3psme_c\",\n\"name\":\"5_enolpyruvylshikimate_3_phosphate\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"phe_L_c\",\n\"name\":\"L_phenylalanine\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"R_3hhdccoa_c\",\n\"name\":\"3R__3_hydroxyhexadecanoyl_CoA\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"pg161_c\",\n\"name\":\"phosphatidylglycerol_dihexadec_9_enoyl_\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"damp_c\",\n\"name\":\"dAMP\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"dadp_c\",\n\"name\":\"dADP\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"lys_L_c\",\n\"name\":\"L_lysine\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"udpgal_c\",\n\"name\":\"UDP_galactose\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"12ppd_S_e\",\n\"name\":\"1_2_propanediol\",\n\"compartment\":\"e\"\n},\n{\n\"id\":\"gcald_c\",\n\"name\":\"glycolaldehyde\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"clac_c\",\n\"name\":\"chloroacetate\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"pmtcoa_c\",\n\"name\":\"hexadecanoyl_CoA\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"uAgla_c\",\n\"name\":\"UDP_N_acetylmuramoyl_L_alanyl_D_glutamyl_L_lysyl_D_alanyl_D_alanine\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"hneuropn_c\",\n\"name\":\"hydroxyneurosporene\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"12ppd_S_p\",\n\"name\":\"1_2_propanediol\",\n\"compartment\":\"p\"\n},\n{\n\"id\":\"3hcdd5ecoa_c\",\n\"name\":\"3S__3_hydroxy_cis_dodec_5_enoyl_CoA\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"R_3hchd9ecoa_c\",\n\"name\":\"3R__3_hydroxy_cis_hexadec_9_enoyl_CoA\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"ttdca_c\",\n\"name\":\"tetradecanoate\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"trnatyr_c\",\n\"name\":\"tRNA_Tyr_\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"3ocpalm9eACP_c\",\n\"name\":\"3_oxo_cis_hexadec_9_enoyl__acyl_carrier_protein_\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"btcoa_c\",\n\"name\":\"butyryl_CoA\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"protrna_c\",\n\"name\":\"L_prolyl_tRNA_Pro_\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"dcamp_c\",\n\"name\":\"adenylo_succinate\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"ps180_c\",\n\"name\":\"phosphatidyl_L_serine_dioctadecanoyl_\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"dmtsphedn_c\",\n\"name\":\"demethylspheroidene\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"prbamp_c\",\n\"name\":\"phosphoribosyl_AMP\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"toctd2eACP_c\",\n\"name\":\"trans_octadec_2_enoyl__acyl_carrier_protein_\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"so3_c\",\n\"name\":\"HSO3_\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"glutrna_c\",\n\"name\":\"L_glutamyl_tRNA_Glu_\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"prpp_c\",\n\"name\":\"5_phosphoribosyl_1_pyrophosphate\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"mlthf_c\",\n\"name\":\"5_10_methylenetetrahydrofolate\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"imacp_c\",\n\"name\":\"imidazol_acetol_phosphate\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"mg2_c\",\n\"name\":\"Mg2_\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"mg2_e\",\n\"name\":\"Mg2_\",\n\"compartment\":\"e\"\n},\n{\n\"id\":\"apoACP_c\",\n\"name\":\"apo__acyl_carrier_protein_\",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id\":\"pyr_c\",\n\"name\":\"pyruvate\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"uaccg_c\",\n\"name\":\"UDP_N_acetyl_3_O__1_carboxyvinyl__D_glucosamine\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"icit_c\",\n\"name\":\"threo_D_isocitrate\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"2Rethmalcoa_c\",\n\"name\":\"2R__ethylmalonyl_CoA\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"fad_c\",\n\"name\":\"FAD\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"N1aspmd_c\",\n\"name\":\"N_acetylspermidine\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"mmcoa_R_c\",\n\"name\":\"R__methylmalonyl_CoA\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"spmd_c\",\n\"name\":\"spermidine\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"R_3hoctdc_c\",\n\"name\":\"3R__3_hydroxyoctadecanoate\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"btn_c\",\n\"name\":\"biotin\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"2ippa_c\",\n\"name\":\"2S__2_isopropylmalate\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"arog_c\",\n\"name\":\"L_arogenate\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"thdp_c\",\n\"name\":\"tetrahydrodipicolinate\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"val_L_c\",\n\"name\":\"L_valine\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"hdceap_c\",\n\"name\":\"hexadec_9_enoyl_phosphate\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"etha_e\",\n\"name\":\"ethanolamine\",\n\"compartment\":\"e\"\n},\n{\n\"id\":\"fald_p\",\n\"name\":\"formaldehyde\",\n\"compartment\":\"p\"\n},\n{\n\"id\":\"fdp_c\",\n\"name\":\"D_fructose_1_6_bisphosphate\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"adocblp_c\",\n\"name\":\"adenosylcobalamin_5__phosphate\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"meoh_p\",\n\"name\":\"methanol\",\n\"compartment\":\"p\"\n},\n{\n\"id\":\"hpyr_c\",\n\"name\":\"hydroxypyruvate\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"trnagln_c\",\n\"name\":\"tRNA_Gln_\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"etha_p\",\n\"name\":\"ethanolamine\",\n\"compartment\":\"p\"\n},\n{\n\"id\":\"r5p_c\",\n\"name\":\"D_ribose_5_phosphate\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"3hoctACP_c\",\n\"name\":\"3R__3_hydroxyoctanoyl__acyl_carrier_protein_\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"his_L_c\",\n\"name\":\"L_histidine\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"meoh_e\",\n\"name\":\"methanol\",\n\"compartment\":\"e\"\n},\n{\n\"id\":\"mlthf6glu_c\",\n\"name\":\"methylene_tetrahydropteroyl__gamma_Glu_6\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"fald_e\",\n\"name\":\"formaldehyde\",\n\"compartment\":\"e\"\n},\n{\n\"id\":\"fald_c\",\n\"name\":\"formaldehyde\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"mptamp_c\",\n\"name\":\"molybdopterin_AMP\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"hemeO_c\",\n\"name\":\"heme_o\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"dhnpt_c\",\n\"name\":\"7_8_dihydro_D_neopterin\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"h2mpt_c\",\n\"name\":\"7_8_dihydromethanopterin\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"ru5p_D_c\",\n\"name\":\"D_ribulose_5_phosphate\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"23dpg_c\",\n\"name\":\"2_3_bisphospho_D_glycerate\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"t3c7mrseACP_c\",\n\"name\":\"trans_3_cis_7_tetradecenoyl__acyl_carrier_protein_\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"3oocoa_c\",\n\"name\":\"3_oxooctanoyl_CoA\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"1agpe181_c\",\n\"name\":\"1_octadec_9_enoyl_sn_glycero_3_phosphoethanolamine\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"ser_D_c\",\n\"name\":\"D_serine\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"xtsn_c\",\n\"name\":\"xanthosine\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"mlh4mpt_c\",\n\"name\":\"5_10_methylenetetrahydromethanopterin\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"suchms_c\",\n\"name\":\"O_succinyl_L_homoserine\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"uamag_c\",\n\"name\":\"UDP_N_acetylmuramoyl_L_alanyl_D_glutamate\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"cl_c\",\n\"name\":\"Cl_\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"alaLgluD_c\",\n\"name\":\"L_Ala_D_Glu\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"mpe160_c\",\n\"name\":\"phosphatidyl_N_methylethanolamine_dihexadecanoyl_\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"gudac_c\",\n\"name\":\"guanidinoacetate\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"cl_e\",\n\"name\":\"Cl_\",\n\"compartment\":\"e\"\n},\n{\n\"id\":\"lyxnt_e\",\n\"name\":\"L_lyxonate\",\n\"compartment\":\"e\"\n},\n{\n\"id\":\"k_p\",\n\"name\":\"K_\",\n\"compartment\":\"p\"\n},\n{\n\"id\":\"23dh3oxanth_c\",\n\"name\":\"2_3_dihydro_3_oxo_anthranilate\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"6hmhptpp_c\",\n\"name\":\"6_hydroxymethyl_dihydropterin_diphosphate\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"dc2coa_c\",\n\"name\":\"trans_dec_2_enoyl_CoA\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"ump_c\",\n\"name\":\"UMP\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"2ommbl_c\",\n\"name\":\"2_octaprenyl_3_methyl_6_methoxy_1_4_benzoquinol\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"cl_p\",\n\"name\":\"Cl_\",\n\"compartment\":\"p\"\n},\n{\n\"id\":\"lyxnt_p\",\n\"name\":\"L_lyx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n\"id\":\"thilps_c\",\n\"name\":\"thiI_persulfide\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"3hcmrs7eACP_c\",\n\"name\":\"3R__3_hydroxy_cis_tetradec_7_enoyl__acyl_carrier_protein_\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"ala_B_c\",\n\"name\":\"b_alanine\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"dca_e\",\n\"name\":\"decanoate\",\n\"compartment\":\"e\"\n},\n{\n\"id\":\"3hocoa_c\",\n\"name\":\"3S__3_hydroxyoctanoyl_CoA\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"dca_c\",\n\"name\":\"decanoate\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"acetmurpentpeptdpdcp_c\",\n\"name\":\"N_acetylmuramoyl_pentapeptide_diphosphoundecaprenol\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"R_3hmrscoa_c\",\n\"name\":\"3R__3_hydroxytetradecanoyl_CoA\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"fpram_c\",\n\"name\":\"5_phosphoribosyl_N_formylglycineamidine\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"lgt_S_c\",\n\"name\":\"S_lactoylglutathione\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"dahetbclphd_c\",\n\"name\":\"2_desacetyl_2_hydroxyethyl_bacteriochlorophyllidea\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"udp_c\",\n\"name\":\"UDP\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"metmetacc_c\",\n\"name\":\"methylated_methyl_acceptor\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"pser_L_c\",\n\"name\":\"3_phospho_L_serine\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"dmetmetacc_c\",\n\"name\":\"demethylated_methyl_acceptor\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"cyan_c\",\n\"name\":\"cyanide\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"hdca_c\",\n\"name\":\"hexadecanoate\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"mtoxneuropn_c\",\n\"name\":\"methoxyneurosporene\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"ppap_c\",\n\"name\":\"propionylphosphate\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"dgtp_c\",\n\"name\":\"dGTP\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"sucorn_c\",\n\"name\":\"N2_succinyl_L_ornithine\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"mma_e\",\n\"name\":\"methylamine\",\n\"compartment\":\"e\"\n},\n{\n\"id\":\"3hbcoa_c\",\n\"name\":\"S__3_hydroxybutanoyl_CoA\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"akg_c\",\n\"name\":\"2_oxoglutarate\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"lyx_L_p\",\n\"name\":\"L_lyxose\",\n\"compartment\":\"p\"\n},\n{\n\"id\":\"mma_c\",\n\"name\":\"methylamine\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"uSsact_c\",\n\"name\":\"unsulfurated_sulfur_acceptor\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"lipidX_c\",\n\"name\":\"2_3_bis_3_hydroxymyristoyl__b_D_glucosaminyl_1_phosphate\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"akg_e\",\n\"name\":\"2_oxoglutarate\",\n\"compartment\":\"e\"\n},\n{\n\"id\":\"lyx_L_e\",\n\"name\":\"L_lyxose\",\n\"compartment\":\"e\"\n},\n{\n\"id\":\"akg_p\",\n\"name\":\"2_oxoglutarate\",\n\"compartment\":\"p\"\n},\n{\n\"id\":\"ddca_c\",\n\"name\":\"dodecanoate\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"t3cdd5ecoa_c\",\n\"name\":\"trans_3_cis_5_dodecenoyl_CoA\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"malACP_c\",\n\"name\":\"malonyl__acyl_carrier_protein_\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"5mthf_c\",\n\"name\":\"5_methyltetrahydrofolate\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"1pyr5c_c\",\n\"name\":\"S__1_pyrroline_5_carboxylate\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"udpg_c\",\n\"name\":\"UDP_glucose\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"2me4p_c\",\n\"name\":\"2_C_methyl_D_erythritol_4_phosphate\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"no_c\",\n\"name\":\"NO\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"lipidAds_c\",\n\"name\":\"lipid_A_disaccharide\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"gthrd_c\",\n\"name\":\"glutathione\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"pro_L_c\",\n\"name\":\"L_proline\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"pnto_R_c\",\n\"name\":\"R__pantothenate\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"3hdcoa_c\",\n\"name\":\"3S__3_hydroxydecanoyl_CoA\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"mqn8_c\",\n\"name\":\"menaquinone_8\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"air_c\",\n\"name\":\"5_aminoimidazole_ribonucleotide\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"mfr_b__c\",\n\"name\":\"methanofuran\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"but_c\",\n\"name\":\"butyrate\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"3ocmrs7eACP_c\",\n\"name\":\"3_oxo_cis_tetradec_7_enoyl__acyl_carrier_protein_\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"dhpmp_c\",\n\"name\":\"dihydroneopterin_phosphate\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"glu5p_c\",\n\"name\":\"L_glutamate_5_phosphate\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"dgdp_c\",\n\"name\":\"dGDP\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"pg160_c\",\n\"name\":\"phosphatidylglycerol_dihexadecanoyl_\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"ctp_c\",\n\"name\":\"CTP\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"pre6a_c\",\n\"name\":\"precorrin_6A\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"alaala_c\",\n\"name\":\"D_alanyl_D_alanine\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"alagDgluDAPDala_c\",\n\"name\":\"L_Ala_gamma_D_Glu_DAP_D_Ala\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"thisamp_c\",\n\"name\":\"adenylated_thiS\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"3hcoctd11ecoa_c\",\n\"name\":\"3S__3_hydroxy_cis_octadec_11_enoyl_CoA\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"dgmp_c\",\n\"name\":\"dGMP\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"3pg_c\",\n\"name\":\"3_phospho_D_glycerate\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"bmmalcoa_c\",\n\"name\":\"erythro_b_methylmalyl_CoA\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"imgly_c\",\n\"name\":\"iminoglycine\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"ps181_c\",\n\"name\":\"phosphatidyl_L_serine_dioctadec_9_enoyl_\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"r1p_c\",\n\"name\":\"alpha_D_ribose_1_phosphate\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"octa_c\",\n\"name\":\"octanoate\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"2cpr5p_c\",\n\"name\":\"1__2_carboxyphenylamino__1_deoxy_D_ribulose_5_phosphate\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"acg5sa_c\",\n\"name\":\"N_acetyl_L_glutamate_5_semialdehyde\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"dtdp_c\",\n\"name\":\"dTDP\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"1agpc181_c\",\n\"name\":\"1_octadec_9_enoyl_sn_glycero_3_phosphocholine\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"dcmp_c\",\n\"name\":\"dCMP\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"ddcacoa_c\",\n\"name\":\"dodecanoyl_CoA\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"glutrna_gln__c\",\n\"name\":\"L_glutamyl_tRNA_Gln_\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"na1_c\",\n\"name\":\"Na_\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"na1_e\",\n\"name\":\"Na_\",\n\"compartment\":\"e\"\n},\n{\n\"id\":\"na1_p\",\n\"name\":\"Na_\",\n\"compartment\":\"p\"\n},\n{\n\"id\":\"dhap_c\",\n\"name\":\"glycerone_phosphate\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"25drapp_c\",\n\"name\":\"2_5_diamino_6__ribosylamino__4__3H__pyrimidinone_5__phosphate\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"zcar_e\",\n\"name\":\"zeta_carotene\",\n\"compartment\":\"e\"\n},\n{\n\"id\":\"thisthilads_c\",\n\"name\":\"thiS_thiI_acyl_disulfide\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"zcar_c\",\n\"name\":\"zeta_carotene\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"3ocvac11eACP_c\",\n\"name\":\"3_oxo_cis_octadec_11_enoyl__acyl_carrier_protein_\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"3ooctACP_c\",\n\"name\":\"3_oxooctanoyl__acyl_carrier_protein_\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"fmn_c\",\n\"name\":\"FMN\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"sucsal_c\",\n\"name\":\"succinate_semialdehyde\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"tyrtrna_c\",\n\"name\":\"L_tyrosyl_tRNA_Tyr_\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"dcdp_c\",\n\"name\":\"dCDP\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"thf5glu_c\",\n\"name\":\"tetrahydropteroyl__gamma_Glu_5\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"tdec2eACP_c\",\n\"name\":\"trans_dec_2_enoyl__acyl_carrier_protein_\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"GlcNacanhMurNac_c\",\n\"name\":\"GlcNAc_1_6_anhMurNAc\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"datp_c\",\n\"name\":\"dATP\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"etha_c\",\n\"name\":\"ethanolamine\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"etgly_c\",\n\"name\":\"N_ethylglycine\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"ala_L_c\",\n\"name\":\"L_alanine\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"gmp_c\",\n\"name\":\"GMP\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"clpnd160_c\",\n\"name\":\"cardiolipin_dihexadecanoyl_\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"trnacys_c\",\n\"name\":\"tRNA_Cys_\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"ahdt_c\",\n\"name\":\"7_8_dihydroneopterin_triphosphate\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"pgp161_c\",\n\"name\":\"phosphatidylglycerolphosphate_dihexadec_9_enoyl_\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"3hpalmACP_c\",\n\"name\":\"3R__3_hydroxyhexadecanoyl__acyl_carrier_protein_\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"nh4_p\",\n\"name\":\"NH3\",\n\"compartment\":\"p\"\n},\n{\n\"id\":\"chor_c\",\n\"name\":\"chorismate\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"phyflun_c\",\n\"name\":\"phytofluene\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"but2eACP_c\",\n\"name\":\"crotonyl__acyl_carrier_protein_\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"phyflun_e\",\n\"name\":\"phytofluene\",\n\"compartment\":\"e\"\n},\n{\n\"id\":\"asptrna_asn_c\",\n\"name\":\"L_aspartyl_tRNA_Asn_\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"nh4_e\",\n\"name\":\"NH3\",\n\"compartment\":\"e\"\n},\n{\n\"id\":\"4ahmmp_c\",\n\"name\":\"hydroxymethylpyrimidine\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"acg5p_c\",\n\"name\":\"N_acetylglutamyl_phosphate\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"nh4_c\",\n\"name\":\"NH3\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"dtpcoctpp_c\",\n\"name\":\"di_trans_poly_cis_octaprenyl_diphosphate\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"2mahmp_c\",\n\"name\":\"4_amino_5_hydroxymethyl_2_methylpyrimidine_pyrophosphate\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"4ppcys_c\",\n\"name\":\"R__4__phosphopantothenoyl_L_cysteine\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"acgam_c\",\n\"name\":\"N_acetyl_D_glucosamine\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"3dhsk_c\",\n\"name\":\"3_dehydroshikimate\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"hepdp_c\",\n\"name\":\"all_trans_heptaprenyl_diphosphate\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"pre8_c\",\n\"name\":\"precorrin_8x\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"fmettrna_c\",\n\"name\":\"N_formylmethionyl_tRNA_fMet_\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"t3chd9ecoa_c\",\n\"name\":\"trans_3_cis_9_hexadecenoyl_CoA\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"t2cdd5ecoa_c\",\n\"name\":\"trans_2_cis_5_dodecenoyl_CoA\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"ala_D_c\",\n\"name\":\"D_alanine\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"3php_c\",\n\"name\":\"3_phospho_hydroxypyruvate\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"hspmd_c\",\n\"name\":\"sym_homospermidine\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"araba_e\",\n\"name\":\"L_arabinonate\",\n\"compartment\":\"e\"\n},\n{\n\"id\":\"ncam_c\",\n\"name\":\"nicotinamide\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"rETF_c\",\n\"name\":\"reduced_ETF\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"R_3hoctdccoa_c\",\n\"name\":\"3R__3_hydroxyoctadecanoyl_CoA\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"ps160_c\",\n\"name\":\"phosphatidyl_L_serine_dihexadecanoyl_\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"man6p_c\",\n\"name\":\"D_mannose_6_phosphate\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"glx_c\",\n\"name\":\"glyoxylate\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"araba_p\",\n\"name\":\"L_arabinonate\",\n\"compartment\":\"p\"\n},\n{\n\"id\":\"5apru_c\",\n\"name\":\"5_amino_6__5__phosphoribosylamino_uracil\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"moco_c\",\n\"name\":\"molybdenum_cofactor\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"3oddcoa_c\",\n\"name\":\"3_oxododecanoyl_CoA\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"bclphd_c\",\n\"name\":\"bacteriochlorophyllidea\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"ppi_c\",\n\"name\":\"diphosphate\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"mpe161_c\",\n\"name\":\"phosphatidyl_N_methylethanolamine_dihexadec_9_enoyl_\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"cyst_L_c\",\n\"name\":\"L_cystathionine\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"2kdrib_e\",\n\"name\":\"2_deoxy_D_ribose\",\n\"compartment\":\"e\"\n},\n{\n\"id\":\"pendp_c\",\n\"name\":\"geranylfarnesyl_diphosphate\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"ACP_c\",\n\"name\":\"acyl_carrier_protein_\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"4mop_c\",\n\"name\":\"4_methyl_2_oxopentanoate\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"od2coa_c\",\n\"name\":\"trans_octadec_2_enoyl_CoA\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"cbp_c\",\n\"name\":\"carbamoyl_phosphate\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"1hdecg3p_c\",\n\"name\":\"1_hexadecanoyl_sn_glycerol_3_phosphate\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"3ohdcoa_c\",\n\"name\":\"3_oxohexadecanoyl_CoA\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"cobya_c\",\n\"name\":\"cobyrinate\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"dad_2_c\",\n\"name\":\"5__deoxyadenosine\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"co2_c\",\n\"name\":\"CO2\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"cmp_c\",\n\"name\":\"CMP\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"co2_e\",\n\"name\":\"CO2\",\n\"compartment\":\"e\"\n},\n{\n\"id\":\"2h3oppan_c\",\n\"name\":\"tartronate_semialdehyde\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"dpundcpGlcNacMurNacpentpept_c\",\n\"name\":\"diphosphoundecaprenyl__GlcNAc_MurNAc_pentapeptide\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"xmp_c\",\n\"name\":\"XMP\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"ethlam_c\",\n\"name\":\"ethylamine\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"adcobdam_c\",\n\"name\":\"adenosyl_cobyrinate_a_c_diamide\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"amp_c\",\n\"name\":\"AMP\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"nigos_c\",\n\"name\":\"nigerose\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"sucgsa_c\",\n\"name\":\"N2_succinyl_L_glutamate_5_semialdehyde\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"phpyr_c\",\n\"name\":\"phenylpyruvate\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"pre5_c\",\n\"name\":\"precorrin_5\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"34thsplxanth_c\",\n\"name\":\"3_4_3__4__tetrahydrospirilloxanthin\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"hx2coa_c\",\n\"name\":\"trans_hex_2_enoyl_CoA\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"glyclt_e\",\n\"name\":\"glycolate\",\n\"compartment\":\"e\"\n},\n{\n\"id\":\"db4p_c\",\n\"name\":\"L_3_4_dihydroxybutan_2_one_4_phosphate\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"b2coa_c\",\n\"name\":\"crotonyl_CoA\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"3a2op_c\",\n\"name\":\"1_amino_propan_2_one_3_phosphate\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"glyclt_c\",\n\"name\":\"glycolate\",\n\"compartment\":\"c\"\n},\n{\n\"id\":\"gthox_c\",\n\"name\":\"glutathione_disulfide\",\n\"compartment\":\"c\"\n}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5 phosphate reductoisomerase\",\n\"metabolites\":{\n\"2me4p_c\":1.0,\n\"dxyl5p_c\":-1.0,\n\"h_c\":-1.0,\n\"nadp_c\":1.0,\n\"nadph_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_00455\"\n},\n{\n\"id\":\"PC11M\",\n\"name\":\"precorrin 4 C 11  methyltransferase\",\n\"metabolites\":{\n\"ahcys_c\":1.0,\n\"amet_c\":-1.0,\n\"h_c\":1.0,\n\"pre4_c\":-1.0,\n\"pre5_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_09620\"\n},\n{\n\"id\":\"PSERTr\",\n\"name\":\"phosphoserine aminotransferase\",\n\"metabolites\":{\n\"3php_c\":-1.0,\n\"akg_c\":1.0,\n\"glu_L_c\":-1.0,\n\"pser_L_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_10840\"\n},\n{\n\"id\":\"CAT\",\n\"name\":\"hydroperoxidase\",\n\"metabolites\":{\n\"h2o2_c\":-2.0,\n\"h2o_c\":2.0,\n\"o2_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_09835 or CQW49_06035\"\n},\n{\n\"id\":\"CYO_2p\",\n\"name\":\"cytochrome c oxidase\",\n\"metabolites\":{\n\"ficytc_c\":2.0,\n\"focytc_c\":-2.0,\n\"h2o_c\":1.0,\n\"h_c\":-4.0,\n\"h_p\":2.0,\n\"o2_c\":-0.5\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"((CQW49_10040 and CQW49_10020) or CQW49_13005) and (CQW49_10045 or CQW49_13000)\"\n},\n{\n\"id\":\"UAMAS\",\n\"name\":\"UDP N acetylmuramate alanine ligase\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"ala_L_c\":-1.0,\n\"atp_c\":-1.0,\n\"h_c\":1.0,\n\"pi_c\":1.0,\n\"uama_c\":1.0,\n\"uamr_c\":-1.0\n},\n\"lower_bound\":0,\n\"upper_bound\":1000,\n\"gene_reaction_rule\":\"CQW49_11235\"\n},\n{\n\"id\":\"MNEUROPNDH3\",\n\"name\":\"methoxyneurosporene dehydrogenase 3\",\n\"metabolites\":{\n\"hxysplxanth_c\":1.0,\n\"oxEA_c\":-1.0,\n\"rdEA_c\":1.0,\n\"rdvbin_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"META1_2923\"\n},\n{\n\"id\":\"EX_DM_trnathr\",\n\"name\":\"exchange flux   tRNA Thr \",\n\"metabolites\":{\n\"trnathr_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"MNEUROPNDH2\",\n\"name\":\"methoxyneurosporene dehydrogenase 2\",\n\"metabolites\":{\n\"dhrdpin_c\":1.0,\n\"oxEA_c\":-1.0,\n\"rdEA_c\":1.0,\n\"rdpin_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"META1_2923\"\n},\n{\n\"id\":\"2AGPEAT161acp\",\n\"name\":\"2 acylglycerophosphoethanolamine acyltransferase  n 16 1 \",\n\"metabolites\":{\n\"2agpe161_c\":-1.0,\n\"ACP_c\":1.0,\n\"hdeACP_c\":-1.0,\n\"pe161_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_12415\"\n},\n{\n\"id\":\"PEPGLYCANGT\",\n\"name\":\"peptidoglycan glycosyltransferase\",\n\"metabolites\":{\n\"dpundcpGlcNacMurNacpentpept_c\":1.0,\n\"dtpcudcpp_c\":1.0,\n\"h_c\":-1.0,\n\"uaagmda_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"META1_2497\"\n},\n{\n\"id\":\"MTHFC\",\n\"name\":\"methenyltetrahydrofolate cyclohydrolase\",\n\"metabolites\":{\n\"10fthf_c\":-1.0,\n\"h2o_c\":1.0,\n\"h_c\":-1.0,\n\"methf_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_12215\"\n},\n{\n\"id\":\"MTHFD\",\n\"name\":\"methylenetetrahydrofolate dehydrogenase\",\n\"metabolites\":{\n\"methf_c\":-1.0,\n\"mlthf_c\":1.0,\n\"nadp_c\":1.0,\n\"nadph_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_12210\"\n},\n{\n\"id\":\"THRD_L\",\n\"name\":\"threonine deaminase\",\n\"metabolites\":{\n\"2obut_c\":1.0,\n\"nh4_c\":1.0,\n\"thr_L_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"META1_3241\"\n},\n{\n\"id\":\"EAR60y\",\n\"name\":\"enoyl  acyl carrier protein  reductase  n 6 0 \",\n\"metabolites\":{\n\"h_c\":-1.0,\n\"hexACP_c\":1.0,\n\"nadp_c\":1.0,\n\"nadph_c\":-1.0,\n\"thex2eACP_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_09320 or CQW49_16835\"\n},\n{\n\"id\":\"CDPMEK\",\n\"name\":\"4 diphosphocytidyl 2 C methyl D erythritol kinase\",\n\"metabolites\":{\n\"2p4c2me_c\":1.0,\n\"4c2me_c\":-1.0,\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"h_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_19125\"\n},\n{\n\"id\":\"PGMT\",\n\"name\":\"phosphoglucomutase\",\n\"metabolites\":{\n\"g1p_c\":-1.0,\n\"g6p_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_16590\"\n},\n{\n\"id\":\"PGSA181\",\n\"name\":\"phosphatidylglycerophosphate synthetase  n 18 1 \",\n\"metabolites\":{\n\"cdpdodec11eg_c\":-1.0,\n\"cmp_c\":1.0,\n\"glyc3p_c\":-1.0,\n\"h_c\":1.0,\n\"pgp181_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_03695\"\n},\n{\n\"id\":\"PItex\",\n\"name\":\"phosphate transport via diffusion  extracellular to periplasm \",\n\"metabolites\":{\n\"pi_e\":-1.0,\n\"pi_p\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"ASPCTr\",\n\"name\":\"aspartate carbamoyltransferase\",\n\"metabolites\":{\n\"asp_L_c\":-1.0,\n\"cbasp_c\":1.0,\n\"cbp_c\":-1.0,\n\"h_c\":1.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_10330\"\n},\n{\n\"id\":\"MALtex\",\n\"name\":\"malate transport via diffusion  extracellular to periplasm \",\n\"metabolites\":{\n\"mal_L_e\":-1.0,\n\"mal_L_p\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"CYTK1\",\n\"name\":\"cytidylate kinase\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"cdp_c\":1.0,\n\"cmp_c\":-1.0\n},\n\"lower_bound\":0,\n\"upper_bound\":1000,\n\"gene_reaction_rule\":\"CQW49_09920\"\n},\n{\n\"id\":\"SUCCOAH\",\n\"name\":\"succinyl CoA hydrolase\",\n\"metabolites\":{\n\"coa_c\":1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"succ_c\":1.0,\n\"succoa_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"HNEUROPNMT2\",\n\"name\":\"hydroxyneurosporene methyltransferase 2\",\n\"metabolites\":{\n\"ahcys_c\":1.0,\n\"amet_c\":-1.0,\n\"h_c\":1.0,\n\"hneuropn_c\":-1.0,\n\"mtoxneuropn_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_13335\"\n},\n{\n\"id\":\"2AGPEAT180acp\",\n\"name\":\"2 acylglycerophosphoethanolamine acyltransferase  n 18 0 \",\n\"metabolites\":{\n\"2agpe180_c\":-1.0,\n\"ACP_c\":1.0,\n\"ocdcaACP_c\":-1.0,\n\"pe180_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_12415\"\n},\n{\n\"id\":\"HNEUROPNMT3\",\n\"name\":\"hydroxyneurosporene methyltransferase 3\",\n\"metabolites\":{\n\"ahcys_c\":1.0,\n\"amet_c\":-1.0,\n\"dhanrdvbin_c\":1.0,\n\"h_c\":1.0,\n\"rdpin_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_13335\"\n},\n{\n\"id\":\"HNEUROPNMT4\",\n\"name\":\"hydroxyneurosporene methyltransferase 4\",\n\"metabolites\":{\n\"34thsplxanth_c\":1.0,\n\"ahcys_c\":1.0,\n\"amet_c\":-1.0,\n\"dhrdvbin_c\":-1.0,\n\"h_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_13335\"\n},\n{\n\"id\":\"DHPPDA2\",\n\"name\":\"diaminohydroxyphosphoribosylaminopyrimidine deaminase\",\n\"metabolites\":{\n\"25drapp_c\":-1.0,\n\"5apru_c\":1.0,\n\"h2o_c\":-1.0,\n\"h_c\":-1.0,\n\"nh4_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_19520\"\n},\n{\n\"id\":\"PGSA180\",\n\"name\":\"phosphatidylglycerophosphate synthetase  n 18 0 \",\n\"metabolites\":{\n\"cdpdodecg_c\":-1.0,\n\"cmp_c\":1.0,\n\"glyc3p_c\":-1.0,\n\"h_c\":1.0,\n\"pgp180_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_03695\"\n},\n{\n\"id\":\"CITtex\",\n\"name\":\"citrate transport via diffusion  extracellular to periplasm \",\n\"metabolites\":{\n\"cit_e\":-1.0,\n\"cit_p\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"PHYNDH_e\",\n\"name\":\"phytoene dehydrogenase 1  extracellular \",\n\"metabolites\":{\n\"h2o_e\":2.0,\n\"o2_e\":-1.0,\n\"oxEA_e\":1.0,\n\"phyflun_e\":1.0,\n\"phyn_e\":-1.0,\n\"rdEA_e\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_08235\"\n},\n{\n\"id\":\"HNEUROPNMT6\",\n\"name\":\"hydroxyneurosporene methyltransferase 6\",\n\"metabolites\":{\n\"ahcys_c\":1.0,\n\"amet_c\":-1.0,\n\"h_c\":1.0,\n\"hxysplxanth_c\":-1.0,\n\"splxanth_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_13335\"\n},\n{\n\"id\":\"HNEUROPNMT5\",\n\"name\":\"hydroxyneurosporene methyltransferase 5\",\n\"metabolites\":{\n\"ahcys_c\":1.0,\n\"amet_c\":-1.0,\n\"anrdvbin_c\":1.0,\n\"dhrdpin_c\":-1.0,\n\"h_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_13335\"\n},\n{\n\"id\":\"GLYCL_3\",\n\"name\":\"H protein aminomethyltransferase\",\n\"metabolites\":{\n\"Gcvpdhll_c\":1.0,\n\"h_c\":-1.0,\n\"mlthf_c\":1.0,\n\"nh4_c\":1.0,\n\"pSamdhll_c\":-1.0,\n\"thf_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_13365 or CQW49_20495\"\n},\n{\n\"id\":\"EX_ac_e\",\n\"name\":\"exchange flux   acetate\",\n\"metabolites\":{\n\"ac_e\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":0.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"EX_etma_e\",\n\"name\":\"exchange flux   ethylamine\",\n\"metabolites\":{\n\"etma_e\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":0.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"EDTXS1\",\n\"name\":\"lauroyl acyltransferase\",\n\"metabolites\":{\n\"ACP_c\":1.0,\n\"ddcaACP_c\":-1.0,\n\"kdo2lipid4L_c\":1.0,\n\"kdo2lipid4_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"META1_3702\"\n},\n{\n\"id\":\"PRE3BS\",\n\"name\":\"precorrin 3B synthase\",\n\"metabolites\":{\n\"h2o_c\":1.0,\n\"h_c\":-2.0,\n\"nad_c\":1.0,\n\"nadh_c\":-1.0,\n\"o2_c\":-1.0,\n\"pre3a_c\":-1.0,\n\"pre3b_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"META1_1327\"\n},\n{\n\"id\":\"HACD1\",\n\"name\":\"3 hydroxyacyl CoA dehydrogenase  n 4 0 \",\n\"metabolites\":{\n\"3hbcoa_c\":-1.0,\n\"aacoa_c\":1.0,\n\"h_c\":1.0,\n\"nad_c\":-1.0,\n\"nadh_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_15495 and CQW49_15500\"\n},\n{\n\"id\":\"HACD2\",\n\"name\":\"3 hydroxyacyl CoA dehydrogenase  n 6 0 \",\n\"metabolites\":{\n\"3hhcoa_c\":-1.0,\n\"3ohcoa_c\":1.0,\n\"h_c\":1.0,\n\"nad_c\":-1.0,\n\"nadh_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_15495 and CQW49_15500\"\n},\n{\n\"id\":\"HACD5\",\n\"name\":\"3 hydroxyacyl CoA dehydrogenase  n 12 0 \",\n\"metabolites\":{\n\"3hddcoa_c\":-1.0,\n\"3oddcoa_c\":1.0,\n\"h_c\":1.0,\n\"nad_c\":-1.0,\n\"nadh_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_15495 and CQW49_15500\"\n},\n{\n\"id\":\"HACD6\",\n\"name\":\"3 hydroxyacyl CoA dehydrogenase  n 14 0 \",\n\"metabolites\":{\n\"3htdcoa_c\":-1.0,\n\"3otdcoa_c\":1.0,\n\"h_c\":1.0,\n\"nad_c\":-1.0,\n\"nadh_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_15495 and CQW49_15500\"\n},\n{\n\"id\":\"HACD3\",\n\"name\":\"3 hydroxyacyl CoA dehydrogenase  n 8 0 \",\n\"metabolites\":{\n\"3hocoa_c\":-1.0,\n\"3oocoa_c\":1.0,\n\"h_c\":1.0,\n\"nad_c\":-1.0,\n\"nadh_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_15495 and CQW49_15500\"\n},\n{\n\"id\":\"MTRI2\",\n\"name\":\"5 methylthioribose 1 phosphate isomerase\",\n\"metabolites\":{\n\"5mdr1p_c\":-1.0,\n\"5mdr1p_iso_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_05580\"\n},\n{\n\"id\":\"HACD4\",\n\"name\":\"3 hydroxyacyl CoA dehydrogenase  n 10 0 \",\n\"metabolites\":{\n\"3hdcoa_c\":-1.0,\n\"3odcoa_c\":1.0,\n\"h_c\":1.0,\n\"nad_c\":-1.0,\n\"nadh_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_15495 and CQW49_15500\"\n},\n{\n\"id\":\"ARGTRS\",\n\"name\":\"arginyl tRNA synthetase\",\n\"metabolites\":{\n\"amp_c\":1.0,\n\"arg_L_c\":-1.0,\n\"argtrna_c\":1.0,\n\"atp_c\":-1.0,\n\"ppi_c\":1.0,\n\"trnaarg_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_06210\"\n},\n{\n\"id\":\"AACPS3\",\n\"name\":\"acyl acyl carrier protein synthetase  n 16 0 \",\n\"metabolites\":{\n\"ACP_c\":-1.0,\n\"amp_c\":1.0,\n\"atp_c\":-1.0,\n\"hdca_c\":-1.0,\n\"palmACP_c\":1.0,\n\"ppi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_12415\"\n},\n{\n\"id\":\"AACPS4\",\n\"name\":\"acyl acyl carrier protein synthetase  n 16 1 \",\n\"metabolites\":{\n\"ACP_c\":-1.0,\n\"amp_c\":1.0,\n\"atp_c\":-1.0,\n\"hdcea_c\":-1.0,\n\"hdeACP_c\":1.0,\n\"ppi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_12415\"\n},\n{\n\"id\":\"SHK3Dr\",\n\"name\":\"shikimate 5 dehydrogenase\",\n\"metabolites\":{\n\"3dhsk_c\":1.0,\n\"h_c\":1.0,\n\"nadp_c\":-1.0,\n\"nadph_c\":1.0,\n\"skm_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_06455\"\n},\n{\n\"id\":\"AACPS5\",\n\"name\":\"acyl acyl carrier protein synthetase  n 18 1 \",\n\"metabolites\":{\n\"ACP_c\":-1.0,\n\"amp_c\":1.0,\n\"atp_c\":-1.0,\n\"ocdcea_c\":-1.0,\n\"octeACP_c\":1.0,\n\"ppi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_12415\"\n},\n{\n\"id\":\"AACPS6\",\n\"name\":\"acyl acyl carrier protein synthetase  n 18 0 \",\n\"metabolites\":{\n\"ACP_c\":-1.0,\n\"amp_c\":1.0,\n\"atp_c\":-1.0,\n\"ocdcaACP_c\":1.0,\n\"ocdca_c\":-1.0,\n\"ppi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_12415\"\n},\n{\n\"id\":\"IGPS\",\n\"name\":\"indole 3 glycerol phosphate synthase\",\n\"metabolites\":{\n\"2cpr5p_c\":-1.0,\n\"3ig3p_c\":1.0,\n\"co2_c\":1.0,\n\"h2o_c\":1.0,\n\"h_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_20175\"\n},\n{\n\"id\":\"EX_h2o_e\",\n\"name\":\"exchange flux   H2O\",\n\"metabolites\":{\n\"h2o_e\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"GLYCLTDx\",\n\"name\":\"glyoxylate reductase\",\n\"metabolites\":{\n\"glx_c\":-1.0,\n\"glyclt_c\":1.0,\n\"h_c\":-1.0,\n\"nad_c\":1.0,\n\"nadh_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_04355 and CQW49_04350 and CQW49_04360 and CQW49_06750\"\n},\n{\n\"id\":\"SULabcpp\",\n\"name\":\"sulfate ABC transporter\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"pi_c\":1.0,\n\"so4_c\":1.0,\n\"so4_p\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"META1_0390 and CQW49_18480 and CQW49_18485 and CQW49_18470 and CQW49_18475\"\n},\n{\n\"id\":\"HACD7\",\n\"name\":\"3 hydroxyacyl CoA dehydrogenase  n 16 0 \",\n\"metabolites\":{\n\"3hhdcoa_c\":-1.0,\n\"3ohdcoa_c\":1.0,\n\"h_c\":1.0,\n\"nad_c\":-1.0,\n\"nadh_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_15495 and CQW49_15500\"\n},\n{\n\"id\":\"SHCHD2\",\n\"name\":\"precorrin 2 dehydrogenase\",\n\"metabolites\":{\n\"dscl_c\":-1.0,\n\"h_c\":1.0,\n\"nad_c\":-1.0,\n\"nadh_c\":1.0,\n\"scl_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_21195\"\n},\n{\n\"id\":\"RIBONAtex\",\n\"name\":\"D ribonate transport via diffusion  extracellular to periplasm \",\n\"metabolites\":{\n\"ribona_e\":-1.0,\n\"ribona_p\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"ADK1\",\n\"name\":\"adenylate kinase\",\n\"metabolites\":{\n\"adp_c\":2.0,\n\"amp_c\":-1.0,\n\"atp_c\":-1.0\n},\n\"lower_bound\":0,\n\"upper_bound\":1000,\n\"gene_reaction_rule\":\"CQW49_10390\"\n},\n{\n\"id\":\"PC6YM\",\n\"name\":\"precorrin 6Y C 5 15  methyltransferase\",\n\"metabolites\":{\n\"ahcys_c\":2.0,\n\"amet_c\":-2.0,\n\"co2_c\":1.0,\n\"h_c\":2.0,\n\"pre6b_c\":-1.0,\n\"pre8_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"META1_0799\"\n},\n{\n\"id\":\"EX_pyr_e\",\n\"name\":\"exchange flux   pyruvate\",\n\"metabolites\":{\n\"pyr_e\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":0.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"SALMMT\",\n\"name\":\"methylation\",\n\"metabolites\":{\n\"ahcys_c\":1.0,\n\"amet_c\":-1.0,\n\"dmetmetacc_c\":-1.0,\n\"h_c\":1.0,\n\"metmetacc_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"GFUCS\",\n\"name\":\"GDP L fucose synthase\",\n\"metabolites\":{\n\"gdpddman_c\":-1.0,\n\"gdpfuc_c\":1.0,\n\"h_c\":-1.0,\n\"nadp_c\":1.0,\n\"nadph_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_14215\"\n},\n{\n\"id\":\"GMPS\",\n\"name\":\"GMP synthetase  ammonia dependent \",\n\"metabolites\":{\n\"amp_c\":1.0,\n\"atp_c\":-1.0,\n\"gmp_c\":1.0,\n\"h_c\":2.0,\n\"nh4_c\":-1.0,\n\"ppi_c\":1.0,\n\"xmp_c\":-1.0\n},\n\"lower_bound\":-1000,\n\"upper_bound\":0,\n\"gene_reaction_rule\":\"CQW49_20775\"\n},\n{\n\"id\":\"POLYPIP\",\n\"name\":\"exopolyphosphatase\",\n\"metabolites\":{\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"pi_c\":1.0,\n\"polypi_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_09430\"\n},\n{\n\"id\":\"DNTPPA\",\n\"name\":\"dihydroneopterin triphosphate pyrophosphohydrolase\",\n\"metabolites\":{\n\"ahdt_c\":-1.0,\n\"dhpmp_c\":1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"ppi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"MALTATr\",\n\"name\":\"maltose acetyltransferase\",\n\"metabolites\":{\n\"accoa_c\":-1.0,\n\"acmalt_c\":1.0,\n\"coa_c\":1.0,\n\"malt_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_03890\"\n},\n{\n\"id\":\"ACACt2pp\",\n\"name\":\"acetoacetate symport  periplasm to cytoplasm \",\n\"metabolites\":{\n\"acac_c\":1.0,\n\"acac_p\":-1.0,\n\"h_c\":1.0,\n\"h_p\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"PYRtex\",\n\"name\":\"pyruvate transport via diffusion  extracellular to periplasm \",\n\"metabolites\":{\n\"pyr_e\":-1.0,\n\"pyr_p\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"GLUTRS\",\n\"name\":\"glutamyl tRNA synthetase\",\n\"metabolites\":{\n\"amp_c\":1.0,\n\"atp_c\":-1.0,\n\"glu_L_c\":-1.0,\n\"glutrna_c\":1.0,\n\"ppi_c\":1.0,\n\"trnaglu_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_09915 or CQW49_09015 or CQW49_04745\"\n},\n{\n\"id\":\"ATPM\",\n\"name\":\"ATP maintenance requirement\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":3.5,\n\"upper_bound\":3.5,\n\"gene_reaction_rule\":\"SP0001\"\n},\n{\n\"id\":\"FE2tex\",\n\"name\":\"iron transport via diffusion  extracellular to periplasm \",\n\"metabolites\":{\n\"fe2_e\":-1.0,\n\"fe2_p\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_11000 or CQW49_10865\"\n},\n{\n\"id\":\"GLXDH\",\n\"name\":\"glyoxylate dehydrogenase\",\n\"metabolites\":{\n\"coa_c\":-1.0,\n\"glx_c\":-1.0,\n\"h_c\":1.0,\n\"nadp_c\":-1.0,\n\"nadph_c\":1.0,\n\"oxalcoa_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"MOBDMPTL\",\n\"name\":\"molybdenum  molybdopterin ligase\",\n\"metabolites\":{\n\"amp_c\":1.0,\n\"h2o_c\":1.0,\n\"h_c\":-1.0,\n\"mobd_c\":-1.0,\n\"moco_c\":1.0,\n\"mptamp_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_20165\"\n},\n{\n\"id\":\"HACYLCOAEPI100\",\n\"name\":\"3 hydroxyacyl CoA epimerase  n 10 0 \",\n\"metabolites\":{\n\"3hdcoa_c\":-1.0,\n\"R_3hdcoa_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_15495 and CQW49_15500\"\n},\n{\n\"id\":\"DB4PS\",\n\"name\":\"3 4 dihydroxy 2 butanone 4 phoshate synthase\",\n\"metabolites\":{\n\"db4p_c\":1.0,\n\"for_c\":1.0,\n\"h_c\":1.0,\n\"ru5p_D_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_18090\"\n},\n{\n\"id\":\"LEUTRS\",\n\"name\":\"leucine tRNA synthetase\",\n\"metabolites\":{\n\"amp_c\":1.0,\n\"atp_c\":-1.0,\n\"leu_L_c\":-1.0,\n\"leutrna_c\":1.0,\n\"ppi_c\":1.0,\n\"trnaleu_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_10935\"\n},\n{\n\"id\":\"GLUPRT\",\n\"name\":\"amidophosphoribosyltransferase  PRPP amidotransferase \",\n\"metabolites\":{\n\"gln_L_c\":-1.0,\n\"glu_L_c\":1.0,\n\"h2o_c\":-1.0,\n\"ppi_c\":1.0,\n\"pram_c\":1.0,\n\"prpp_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_03760\"\n},\n{\n\"id\":\"HNEUROPNMT\",\n\"name\":\"hydroxyneurosporene methyltransferase 1\",\n\"metabolites\":{\n\"ahcys_c\":1.0,\n\"amet_c\":-1.0,\n\"dmtsphedn_c\":-1.0,\n\"h_c\":1.0,\n\"sphedn_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_13335\"\n},\n{\n\"id\":\"PTPAT\",\n\"name\":\"pantetheine phosphate adenylyltransferase\",\n\"metabolites\":{\n\"atp_c\":-1.0,\n\"dpcoa_c\":1.0,\n\"h_c\":-1.0,\n\"pan4p_c\":-1.0,\n\"ppi_c\":1.0\n},\n\"lower_bound\":0,\n\"upper_bound\":1000,\n\"gene_reaction_rule\":\"CQW49_01480\"\n},\n{\n\"id\":\"DDPA\",\n\"name\":\"2 dehydro 3 deoxyphosphoheptonate aldolase\",\n\"metabolites\":{\n\"2dda7p_c\":1.0,\n\"e4p_c\":-1.0,\n\"h2o_c\":-1.0,\n\"pep_c\":-1.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_09090\"\n},\n{\n\"id\":\"ASPtex\",\n\"name\":\"aspartate transport via diffusion  extracellular to periplasm \",\n\"metabolites\":{\n\"asp_L_e\":-1.0,\n\"asp_L_p\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"FBA\",\n\"name\":\"fructose bisphosphate aldolase\",\n\"metabolites\":{\n\"dhap_c\":-1.0,\n\"fdp_c\":1.0,\n\"g3p_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_18395\"\n},\n{\n\"id\":\"HEXTT\",\n\"name\":\"octaprenyl diphosphate synthase 3\",\n\"metabolites\":{\n\"hepdp_c\":1.0,\n\"hexdp_c\":-1.0,\n\"ipdp_c\":-1.0,\n\"ppi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_18820\"\n},\n{\n\"id\":\"RIBtex\",\n\"name\":\"D ribose transport via diffusion  extracellular to periplasm \",\n\"metabolites\":{\n\"rib_D_e\":-1.0,\n\"rib_D_p\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"AKGDH\",\n\"name\":\"2 oxoglutarate dehydrogenase\",\n\"metabolites\":{\n\"akg_c\":-1.0,\n\"co2_c\":1.0,\n\"coa_c\":-1.0,\n\"nad_c\":-1.0,\n\"nadh_c\":1.0,\n\"succoa_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_16390 and CQW49_16395\"\n},\n{\n\"id\":\"LYXtex\",\n\"name\":\"L lyxose transport via diffusion  extracellular to periplasm \",\n\"metabolites\":{\n\"lyx_L_e\":-1.0,\n\"lyx_L_p\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"EAR181y\",\n\"name\":\"enoyl  acyl carrier protein  reductase  n 18 1 \",\n\"metabolites\":{\n\"h_c\":-1.0,\n\"nadp_c\":1.0,\n\"nadph_c\":-1.0,\n\"octeACP_c\":1.0,\n\"t3c11vaceACP_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_09320 or CQW49_16835\"\n},\n{\n\"id\":\"2KDRIBtex\",\n\"name\":\"2 deoxy D ribose transport via diffusion  extracellular to periplasm \",\n\"metabolites\":{\n\"2kdrib_e\":-1.0,\n\"2kdrib_p\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"ALATRS\",\n\"name\":\"alanyl tRNA synthetase\",\n\"metabolites\":{\n\"ala_L_c\":-1.0,\n\"alatrna_c\":1.0,\n\"amp_c\":1.0,\n\"atp_c\":-1.0,\n\"ppi_c\":1.0,\n\"trnaala_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_11105\"\n},\n{\n\"id\":\"PC17M\",\n\"name\":\"precorrin 3B C 17  methyltransferase\",\n\"metabolites\":{\n\"ahcys_c\":1.0,\n\"amet_c\":-1.0,\n\"h_c\":3.0,\n\"pre3b_c\":-1.0,\n\"pre4_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_09600\"\n},\n{\n\"id\":\"HSERTA\",\n\"name\":\"homoserine O acetyltransferase\",\n\"metabolites\":{\n\"accoa_c\":-1.0,\n\"achms_c\":1.0,\n\"coa_c\":1.0,\n\"hom_L_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_17015 or CQW49_22065\"\n},\n{\n\"id\":\"TKT1\",\n\"name\":\"transketolase\",\n\"metabolites\":{\n\"g3p_c\":-1.0,\n\"r5p_c\":1.0,\n\"s7p_c\":-1.0,\n\"xu5p_D_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_18400\"\n},\n{\n\"id\":\"LPLIPAL2C161\",\n\"name\":\"lysophospholipase C2  n 16 1 \",\n\"metabolites\":{\n\"2agpc161_c\":-1.0,\n\"g3pc_c\":1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"hdcea_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_20340\"\n},\n{\n\"id\":\"CCR\",\n\"name\":\"crotonyl CoA reductase\",\n\"metabolites\":{\n\"b2coa_c\":-1.0,\n\"btcoa_c\":1.0,\n\"h_c\":-1.0,\n\"nadp_c\":1.0,\n\"nadph_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_03790\"\n},\n{\n\"id\":\"PHETRS\",\n\"name\":\"phenylalanine tRNA synthetase\",\n\"metabolites\":{\n\"amp_c\":1.0,\n\"atp_c\":-1.0,\n\"phe_L_c\":-1.0,\n\"phetrna_c\":1.0,\n\"ppi_c\":1.0,\n\"trnaphe_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_15750 and CQW49_15760\"\n},\n{\n\"id\":\"P5CR\",\n\"name\":\"pyrroline 5 carboxylate reductase\",\n\"metabolites\":{\n\"1pyr5c_c\":-1.0,\n\"h_c\":-2.0,\n\"nadp_c\":1.0,\n\"nadph_c\":-1.0,\n\"pro_L_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_02875\"\n},\n{\n\"id\":\"EX_5dglcn_e\",\n\"name\":\"exchange flux   5 dehydro D gluconate\",\n\"metabolites\":{\n\"5dglcn_e\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":0.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"ACACT7r\",\n\"name\":\"3 ketoacyl CoA thiolase  n 16 0 \",\n\"metabolites\":{\n\"3ohdcoa_c\":-1.0,\n\"accoa_c\":1.0,\n\"coa_c\":-1.0,\n\"tdcoa_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_15495 and CQW49_15500\"\n},\n{\n\"id\":\"ACACT5r\",\n\"name\":\"3 ketoacyl CoA thiolase  n 12 0 \",\n\"metabolites\":{\n\"3oddcoa_c\":-1.0,\n\"accoa_c\":1.0,\n\"coa_c\":-1.0,\n\"dcacoa_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_15495 and CQW49_15500\"\n},\n{\n\"id\":\"P5CD\",\n\"name\":\"1 pyrroline 5 carboxylate dehydrogenase\",\n\"metabolites\":{\n\"1pyr5c_c\":-1.0,\n\"glu_L_c\":1.0,\n\"h2o_c\":-2.0,\n\"h_c\":1.0,\n\"nad_c\":-1.0,\n\"nadh_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_12965\"\n},\n{\n\"id\":\"ETFDH\",\n\"name\":\"ETF dehydrogenase\",\n\"metabolites\":{\n\"oxETF_c\":1.0,\n\"q_c\":-1.0,\n\"qh2_c\":1.0,\n\"rETF_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_05975 or (CQW49_20235 and CQW49_20230)\"\n},\n{\n\"id\":\"PYAM5POr\",\n\"name\":\"pyridoxamine 5  phosphate oxidase\",\n\"metabolites\":{\n\"h2o2_c\":1.0,\n\"h2o_c\":-1.0,\n\"nh4_c\":1.0,\n\"o2_c\":-1.0,\n\"pyam5p_c\":-1.0,\n\"pydx5p_c\":1.0\n},\n\"lower_bound\":0,\n\"upper_bound\":1000,\n\"gene_reaction_rule\":\"CQW49_11530\"\n},\n{\n\"id\":\"LYSTRS\",\n\"name\":\"lysyl tRNA synthetase\",\n\"metabolites\":{\n\"amp_c\":1.0,\n\"atp_c\":-1.0,\n\"lys_L_c\":-1.0,\n\"lystrna_c\":1.0,\n\"ppi_c\":1.0,\n\"trnalys_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"META1_3184\"\n},\n{\n\"id\":\"EAR141y\",\n\"name\":\"enoyl  acyl carrier protein  reductase  n 14 1 \",\n\"metabolites\":{\n\"h_c\":-1.0,\n\"nadp_c\":1.0,\n\"nadph_c\":-1.0,\n\"t3c7mrseACP_c\":-1.0,\n\"tdeACP_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_09320 or CQW49_16835\"\n},\n{\n\"id\":\"UDPGLCUREPI\",\n\"name\":\"UDP glucuronate 5  epimerase\",\n\"metabolites\":{\n\"udpglcur_c\":-1.0,\n\"udpidour_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_09690\"\n},\n{\n\"id\":\"PC8XM\",\n\"name\":\"precorrin 8X methylmutase\",\n\"metabolites\":{\n\"h_c\":-1.0,\n\"hgbyr_c\":1.0,\n\"pre8_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_09590\"\n},\n{\n\"id\":\"ACACT6r\",\n\"name\":\"3 ketoacyl CoA thiolase  n 14 0 \",\n\"metabolites\":{\n\"3otdcoa_c\":-1.0,\n\"accoa_c\":1.0,\n\"coa_c\":-1.0,\n\"ddcacoa_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_15495 and CQW49_15500\"\n},\n{\n\"id\":\"FBP\",\n\"name\":\"fructose 1 6 bisphosphatase\",\n\"metabolites\":{\n\"f6p_c\":1.0,\n\"fdp_c\":-1.0,\n\"h2o_c\":-1.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_20760\"\n},\n{\n\"id\":\"DALAOX\",\n\"name\":\"glycine oxidase 2\",\n\"metabolites\":{\n\"ala_D_c\":-1.0,\n\"h2o2_c\":1.0,\n\"h2o_c\":-1.0,\n\"nh4_c\":1.0,\n\"o2_c\":-1.0,\n\"pyr_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_14270\"\n},\n{\n\"id\":\"EX_for_e\",\n\"name\":\"exchange flux   formate\",\n\"metabolites\":{\n\"for_e\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":0.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"KAT8\",\n\"name\":\"3 ketoacyl CoA thiolase  n 18 0 \",\n\"metabolites\":{\n\"3oodcoa_c\":-1.0,\n\"accoa_c\":1.0,\n\"coa_c\":-1.0,\n\"pmtcoa_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_15495 and CQW49_15500\"\n},\n{\n\"id\":\"DHAtpp\",\n\"name\":\"glycerone transport via diffusion  periplasm to cytoplasm \",\n\"metabolites\":{\n\"dha_c\":1.0,\n\"dha_p\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"EAR140y\",\n\"name\":\"enoyl  acyl carrier protein  reductase  n 14 0 \",\n\"metabolites\":{\n\"h_c\":-1.0,\n\"myrsACP_c\":1.0,\n\"nadp_c\":1.0,\n\"nadph_c\":-1.0,\n\"tmrs2eACP_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_09320 or CQW49_16835\"\n},\n{\n\"id\":\"ADCPS2\",\n\"name\":\"adenosylcobinamide phosphate synthase\",\n\"metabolites\":{\n\"adcobhex_c\":-1.0,\n\"adocbip_c\":1.0,\n\"adp_c\":1.0,\n\"applp_c\":-1.0,\n\"atp_c\":-1.0,\n\"h_c\":1.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_02445\"\n},\n{\n\"id\":\"LPLIPAL2C181\",\n\"name\":\"lysophospholipase C2  n 18 1 \",\n\"metabolites\":{\n\"2agpc181_c\":-1.0,\n\"g3pc_c\":1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"ocdcea_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_20340\"\n},\n{\n\"id\":\"EAR80y\",\n\"name\":\"enoyl  acyl carrier protein  reductase  n 8 0 \",\n\"metabolites\":{\n\"h_c\":-1.0,\n\"nadp_c\":1.0,\n\"nadph_c\":-1.0,\n\"ocACP_c\":1.0,\n\"toct2eACP_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_09320 or CQW49_16835\"\n},\n{\n\"id\":\"LPLIPAL2C180\",\n\"name\":\"lysophospholipase C2  n 18 0 \",\n\"metabolites\":{\n\"2agpc180_c\":-1.0,\n\"g3pc_c\":1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"ocdca_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_20340\"\n},\n{\n\"id\":\"EX_h_e\",\n\"name\":\"exchange flux   proton\",\n\"metabolites\":{\n\"h_e\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"MOBDabcpp\",\n\"name\":\"molybdate ABC transporter\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"mobd_c\":1.0,\n\"mobd_p\":-1.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_16790 and CQW49_10670 and CQW49_16795\"\n},\n{\n\"id\":\"DHORD\",\n\"name\":\"dihydroorotate dehydrogenase\",\n\"metabolites\":{\n\"dhor_S_c\":-1.0,\n\"h2o2_c\":1.0,\n\"o2_c\":-1.0,\n\"orot_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_09285\"\n},\n{\n\"id\":\"EAR160y\",\n\"name\":\"enoyl  acyl carrier protein  reductase  n 16 0 \",\n\"metabolites\":{\n\"h_c\":-1.0,\n\"nadp_c\":1.0,\n\"nadph_c\":-1.0,\n\"palmACP_c\":1.0,\n\"tpalm2eACP_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_09320 or CQW49_16835\"\n},\n{\n\"id\":\"PEMT181\",\n\"name\":\"phosphatidylethanolamine N methyltransferase  n 18 1 \",\n\"metabolites\":{\n\"ahcys_c\":1.0,\n\"amet_c\":-1.0,\n\"h_c\":1.0,\n\"mpe181_c\":1.0,\n\"pe181_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_06905 or CQW49_20555\"\n},\n{\n\"id\":\"PEMT180\",\n\"name\":\"phosphatidylethanolamine N methyltransferase  n 18 0 \",\n\"metabolites\":{\n\"ahcys_c\":1.0,\n\"amet_c\":-1.0,\n\"h_c\":1.0,\n\"mpe180_c\":1.0,\n\"pe180_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_06905 or CQW49_20555\"\n},\n{\n\"id\":\"SOTA\",\n\"name\":\"succinylornithine transaminase\",\n\"metabolites\":{\n\"akg_c\":-1.0,\n\"glu_L_c\":1.0,\n\"sucgsa_c\":1.0,\n\"sucorn_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_13060\"\n},\n{\n\"id\":\"APRAUR\",\n\"name\":\"5 amino 6  5 phosphoribosylamino uracil reductase\",\n\"metabolites\":{\n\"5aprbu_c\":1.0,\n\"5apru_c\":-1.0,\n\"h_c\":-1.0,\n\"nadp_c\":1.0,\n\"nadph_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_19520\"\n},\n{\n\"id\":\"CA2tex\",\n\"name\":\"calcium transport via diffusion  extracellular to periplasm \",\n\"metabolites\":{\n\"ca2_e\":-1.0,\n\"ca2_p\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"ACACT4r\",\n\"name\":\"3 ketoacyl CoA thiolase  n 10 0 \",\n\"metabolites\":{\n\"3odcoa_c\":-1.0,\n\"accoa_c\":1.0,\n\"coa_c\":-1.0,\n\"occoa_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_15495 and CQW49_15500\"\n},\n{\n\"id\":\"AICART\",\n\"name\":\"phosphoribosylaminoimidazolecarboxamide formyltransferase\",\n\"metabolites\":{\n\"10fthf_c\":-1.0,\n\"aicar_c\":-1.0,\n\"fprica_c\":1.0,\n\"thf_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_01745\"\n},\n{\n\"id\":\"NADS1\",\n\"name\":\"NH3 dependent NAD    synthetase\",\n\"metabolites\":{\n\"amp_c\":1.0,\n\"atp_c\":-1.0,\n\"dnad_c\":-1.0,\n\"h_c\":1.0,\n\"nad_c\":1.0,\n\"nh4_c\":-1.0,\n\"ppi_c\":1.0\n},\n\"lower_bound\":-1000,\n\"upper_bound\":0,\n\"gene_reaction_rule\":\"CQW49_00090\"\n},\n{\n\"id\":\"HACYLCOAEPI140\",\n\"name\":\"3 hydroxyacyl CoA epimerase  n 14 0 \",\n\"metabolites\":{\n\"3htdcoa_c\":-1.0,\n\"R_3hmrscoa_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_15495 and CQW49_15500\"\n},\n{\n\"id\":\"NADS2\",\n\"name\":\"glutamine dependent NAD    synthetase\",\n\"metabolites\":{\n\"amp_c\":1.0,\n\"atp_c\":-1.0,\n\"dnad_c\":-1.0,\n\"gln_L_c\":-1.0,\n\"glu_L_c\":1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"nad_c\":1.0,\n\"ppi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_00090\"\n},\n{\n\"id\":\"HPPK2\",\n\"name\":\"2 amino 4 hydroxy 6 hydroxymethyldihydropteridine pyrophosphokinase\",\n\"metabolites\":{\n\"6hmhpt_c\":-1.0,\n\"6hmhptpp_c\":1.0,\n\"amp_c\":1.0,\n\"atp_c\":-1.0,\n\"h_c\":1.0\n},\n\"lower_bound\":0,\n\"upper_bound\":1000,\n\"gene_reaction_rule\":\"CQW49_10265\"\n},\n{\n\"id\":\"COBALT2tpp\",\n\"name\":\"Cobalt transporter  periplasm to cytoplasm \",\n\"metabolites\":{\n\"cobalt2_c\":1.0,\n\"cobalt2_p\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"META1_1333 and META1_1332\"\n},\n{\n\"id\":\"RNDR3\",\n\"name\":\"CDP reductase\",\n\"metabolites\":{\n\"cdp_c\":-1.0,\n\"dcdp_c\":1.0,\n\"h2o_c\":1.0,\n\"h_c\":-2.0,\n\"trdox_c\":1.0,\n\"trdrd_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_05140 and META2_0021\"\n},\n{\n\"id\":\"ENCOAI81\",\n\"name\":\"enoyl CoA isomerase  n 8 0 \",\n\"metabolites\":{\n\"coct3ecoa_c\":1.0,\n\"oc2coa_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_15495 and CQW49_15500\"\n},\n{\n\"id\":\"RNDR2\",\n\"name\":\"GDP reductase\",\n\"metabolites\":{\n\"dgdp_c\":1.0,\n\"gdp_c\":-1.0,\n\"h2o_c\":1.0,\n\"h_c\":-2.0,\n\"trdox_c\":1.0,\n\"trdrd_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_05140 and META2_0021\"\n},\n{\n\"id\":\"UAGDP\",\n\"name\":\"N acetylglucosamine 1 phosphate uridyltransferase\",\n\"metabolites\":{\n\"acgam1p_c\":-1.0,\n\"h_c\":-1.0,\n\"ppi_c\":1.0,\n\"uacgam_c\":1.0,\n\"utp_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_09125\"\n},\n{\n\"id\":\"PDX5PS2\",\n\"name\":\"pyridoxine 5  phosphate synthase\",\n\"metabolites\":{\n\"3a2op_c\":-1.0,\n\"dxyl5p_c\":-1.0,\n\"h2o_c\":2.0,\n\"h_c\":1.0,\n\"pdx5p_c\":1.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_13430\"\n},\n{\n\"id\":\"RNDR1\",\n\"name\":\"ADP reductase\",\n\"metabolites\":{\n\"adp_c\":-1.0,\n\"dadp_c\":1.0,\n\"h2o_c\":1.0,\n\"h_c\":-2.0,\n\"trdox_c\":1.0,\n\"trdrd_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_05140 and META2_0021\"\n},\n{\n\"id\":\"AKGtex\",\n\"name\":\"a ketoglutarate transport via diffusion  extracellular to periplasm \",\n\"metabolites\":{\n\"akg_e\":-1.0,\n\"akg_p\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"PUNP8\",\n\"name\":\"adenosine phosphorylase\",\n\"metabolites\":{\n\"ade_c\":1.0,\n\"adn_c\":-1.0,\n\"pi_c\":-1.0,\n\"r1p_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"L_LALDtex\",\n\"name\":\"L lactaldehyde transport via diffusion  extracellular to periplasm \",\n\"metabolites\":{\n\"lald_L_e\":-1.0,\n\"lald_L_p\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"PUNP9\",\n\"name\":\"5  deoxyadenosine phosphorylase\",\n\"metabolites\":{\n\"5dr1p_c\":1.0,\n\"ade_c\":1.0,\n\"dad_2_c\":-1.0,\n\"pi_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_00280\"\n},\n{\n\"id\":\"L_LACt2rpp\",\n\"name\":\" S  lactate transport  periplasm to cytoplasm \",\n\"metabolites\":{\n\"h_c\":1.0,\n\"h_p\":-1.0,\n\"lac_L_c\":1.0,\n\"lac_L_p\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"EAR40y\",\n\"name\":\"enoyl  acyl carrier protein  reductase  n 4 0 \",\n\"metabolites\":{\n\"but2eACP_c\":-1.0,\n\"butACP_c\":1.0,\n\"h_c\":-1.0,\n\"nadp_c\":1.0,\n\"nadph_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_09320 or CQW49_16835\"\n},\n{\n\"id\":\"ALAGLUEPI\",\n\"name\":\"L Ala D L Glu epimerase\",\n\"metabolites\":{\n\"alaLgluD_c\":-1.0,\n\"alaglu_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_03145\"\n},\n{\n\"id\":\"GPDDA1\",\n\"name\":\"sn Glycero 3 phosphocholine glycerophosphohydrolase\",\n\"metabolites\":{\n\"chol_c\":1.0,\n\"g3pc_c\":-1.0,\n\"glyc3p_c\":1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_04170\"\n},\n{\n\"id\":\"GPDDA2\",\n\"name\":\"sn Glycero 3 phosphoethanolamine glycerophosphohydrolase\",\n\"metabolites\":{\n\"etha_c\":1.0,\n\"g3pe_c\":-1.0,\n\"glyc3p_c\":1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_04170\"\n},\n{\n\"id\":\"DAHETBCLPHDDH\",\n\"name\":\"2 desacetyl 2 hydroxyethyl bacteriochlorophyllide a dehydrogenase\",\n\"metabolites\":{\n\"bclphd_c\":1.0,\n\"dahetbclphd_c\":-1.0,\n\"h_c\":2.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_22180\"\n},\n{\n\"id\":\"PUNP7\",\n\"name\":\"xanthosine phosphorylase\",\n\"metabolites\":{\n\"pi_c\":-1.0,\n\"r1p_c\":1.0,\n\"xan_c\":1.0,\n\"xtsn_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_15640\"\n},\n{\n\"id\":\"EX_DM_trnaala\",\n\"name\":\"exchange flux   tRNA Ala \",\n\"metabolites\":{\n\"trnaala_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"GLNTRAT\",\n\"name\":\"glutamyl tRNA amidotransferase\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"gln_L_c\":-1.0,\n\"glntrna_c\":1.0,\n\"glu_L_c\":1.0,\n\"glutrna_gln__c\":-1.0,\n\"h2o_c\":-1.0,\n\"h_c\":2.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"(CQW49_01110 and CQW49_01100 and CQW49_01095) or (CQW49_00575 and CQW49_11960 and CQW49_01095)\"\n},\n{\n\"id\":\"ACACT3r\",\n\"name\":\"3 ketoacyl CoA thiolase  n 8 0 \",\n\"metabolites\":{\n\"3oocoa_c\":-1.0,\n\"accoa_c\":1.0,\n\"coa_c\":-1.0,\n\"hxcoa_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_15495 and CQW49_15500\"\n},\n{\n\"id\":\"EX_DM_trnaile\",\n\"name\":\"exchange flux   tRNA Ile \",\n\"metabolites\":{\n\"trnaile_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"EX_photon_e\",\n\"name\":\"exchange flux   light\",\n\"metabolites\":{\n\"photon_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":0.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"DCAtex\",\n\"name\":\"decanoate transport via diffusion  extracellular to periplasm \",\n\"metabolites\":{\n\"dca_e\":-1.0,\n\"dca_p\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"3HBCDH\",\n\"name\":\"3 hydroxybutyryl CoA dehydrogenase\",\n\"metabolites\":{\n\"3hbcoa_c\":-1.0,\n\"aacoa_c\":1.0,\n\"h_c\":1.0,\n\"nadp_c\":-1.0,\n\"nadph_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_20240\"\n},\n{\n\"id\":\"GCALDDr\",\n\"name\":\"glycolaldehyde dehydrogenase\",\n\"metabolites\":{\n\"gcald_c\":-1.0,\n\"glyclt_c\":1.0,\n\"h2o_c\":-1.0,\n\"h_c\":2.0,\n\"nad_c\":-1.0,\n\"nadh_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_11425\"\n},\n{\n\"id\":\"ACACT2r\",\n\"name\":\"3 ketoacyl CoA thiolase  n 6 0 \",\n\"metabolites\":{\n\"3ohcoa_c\":-1.0,\n\"accoa_c\":1.0,\n\"btcoa_c\":1.0,\n\"coa_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_15495 and CQW49_15500\"\n},\n{\n\"id\":\"PPNDH\",\n\"name\":\"prephenate dehydratase\",\n\"metabolites\":{\n\"co2_c\":1.0,\n\"h2o_c\":1.0,\n\"h_c\":-1.0,\n\"phpyr_c\":1.0,\n\"pphn_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_04590\"\n},\n{\n\"id\":\"EX_xylnt_D_e\",\n\"name\":\"exchange flux   D xylonate\",\n\"metabolites\":{\n\"xylnt_D_e\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":0.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"FPGS8\",\n\"name\":\"folylpolyglutamate synthase 2\",\n\"metabolites\":{\n\"10fthf5glu_c\":-1.0,\n\"10fthf6glu_c\":1.0,\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"glu_L_c\":-1.0,\n\"h_c\":1.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_15430\"\n},\n{\n\"id\":\"ACtex\",\n\"name\":\"acetate transport via diffusion  extracellular to periplasm \",\n\"metabolites\":{\n\"ac_e\":-1.0,\n\"ac_p\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"AHC\",\n\"name\":\"S adenosylhomocysteine hydrolase\",\n\"metabolites\":{\n\"adn_c\":1.0,\n\"ahcys_c\":-1.0,\n\"h2o_c\":-1.0,\n\"hcys_L_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_14290\"\n},\n{\n\"id\":\"ALATA_D\",\n\"name\":\"D alanine aminotransferase\",\n\"metabolites\":{\n\"akg_c\":1.0,\n\"ala_D_c\":1.0,\n\"glu_D_c\":-1.0,\n\"pyr_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"META1_0774\"\n},\n{\n\"id\":\"ZCARDS2\",\n\"name\":\"zeta carotene desaturase 2\",\n\"metabolites\":{\n\"h2o_c\":2.0,\n\"neuropn_c\":-1.0,\n\"o2_c\":-1.0,\n\"oxEA_c\":1.0,\n\"rdEA_c\":-1.0,\n\"tlycopn_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"META1_3670\"\n},\n{\n\"id\":\"ADSK\",\n\"name\":\"adenylylsulfate kinase\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"aps_c\":-1.0,\n\"atp_c\":-1.0,\n\"h_c\":1.0,\n\"paps_c\":1.0\n},\n\"lower_bound\":0,\n\"upper_bound\":1000,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"GTPCII2\",\n\"name\":\"GTP cyclohydrolase II\",\n\"metabolites\":{\n\"25drapp_c\":1.0,\n\"for_c\":1.0,\n\"gtp_c\":-1.0,\n\"h2o_c\":-3.0,\n\"h_c\":3.0,\n\"ppi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_18090\"\n},\n{\n\"id\":\"HACYLCOAEPI120\",\n\"name\":\"3 hydroxyacyl CoA epimerase  n 12 0 \",\n\"metabolites\":{\n\"3hddcoa_c\":-1.0,\n\"R_3hddcoa_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_15495 and CQW49_15500\"\n},\n{\n\"id\":\"LYXNTtex\",\n\"name\":\"L lyxonate transport via diffusion  extracellular to periplasm \",\n\"metabolites\":{\n\"lyxnt_e\":-1.0,\n\"lyxnt_p\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"ENCOAI61\",\n\"name\":\"enoyl CoA isomerase  n 6 0 \",\n\"metabolites\":{\n\"ch3ecoa_c\":1.0,\n\"hx2coa_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_15495 and CQW49_15500\"\n},\n{\n\"id\":\"TDSK\",\n\"name\":\"tetraacyldisaccharide 4  kinase\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"h_c\":1.0,\n\"lipidA_c\":1.0,\n\"lipidAds_c\":-1.0\n},\n\"lower_bound\":0,\n\"upper_bound\":1000,\n\"gene_reaction_rule\":\"CQW49_17610\"\n},\n{\n\"id\":\"APG3PAT160\",\n\"name\":\"glycerol 3 phosphate synthetase  n 16 0 \",\n\"metabolites\":{\n\"1hdecg3p_c\":1.0,\n\"glyc3p_c\":-1.0,\n\"hdcap_c\":-1.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_01070\"\n},\n{\n\"id\":\"ACALDtpp\",\n\"name\":\"acetaldehyde transport via diffusion  periplasm to cytoplasm \",\n\"metabolites\":{\n\"acald_c\":1.0,\n\"acald_p\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"APG3PAT161\",\n\"name\":\"glycerol 3 phosphate synthetase  n 16 1 \",\n\"metabolites\":{\n\"1hdec9eg3p_c\":1.0,\n\"glyc3p_c\":-1.0,\n\"hdceap_c\":-1.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_01070\"\n},\n{\n\"id\":\"ADSS\",\n\"name\":\"adenylosuccinate synthetase\",\n\"metabolites\":{\n\"asp_L_c\":-1.0,\n\"dcamp_c\":1.0,\n\"gdp_c\":1.0,\n\"gtp_c\":-1.0,\n\"h_c\":2.0,\n\"imp_c\":-1.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_06970\"\n},\n{\n\"id\":\"FACOAL60\",\n\"name\":\"fatty acyl CoA synthetase  n 6 0 \",\n\"metabolites\":{\n\"amp_c\":1.0,\n\"atp_c\":-1.0,\n\"coa_c\":-1.0,\n\"hxa_c\":-1.0,\n\"hxcoa_c\":1.0,\n\"ppi_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_01835\"\n},\n{\n\"id\":\"EX_DM_AMOB\",\n\"name\":\"exchange flux   S  adenosyl 4 methylthio 2 oxobutanoate\",\n\"metabolites\":{\n\"amob_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"ACACT1r\",\n\"name\":\"acetyl CoA C acetyltransferase\",\n\"metabolites\":{\n\"aacoa_c\":1.0,\n\"accoa_c\":-2.0,\n\"coa_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_15495 or CQW49_17750\"\n},\n{\n\"id\":\"GLUTRS_Gln_\",\n\"name\":\"nondiscriminating glutamyl tRNA synthetase\",\n\"metabolites\":{\n\"amp_c\":1.0,\n\"atp_c\":-1.0,\n\"glu_L_c\":-1.0,\n\"glutrna_gln__c\":1.0,\n\"h_c\":-1.0,\n\"ppi_c\":1.0,\n\"trnagln_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_09015\"\n},\n{\n\"id\":\"CYOO_4p\",\n\"name\":\"cytochrome o ubiquinol oxidase\",\n\"metabolites\":{\n\"h2o_c\":1.0,\n\"h_c\":-4.0,\n\"h_p\":4.0,\n\"o2_c\":-0.5,\n\"q_c\":1.0,\n\"qh2_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_05685 and CQW49_05690 and CQW49_05695 and CQW49_05700\"\n},\n{\n\"id\":\"MEOHDH\",\n\"name\":\"methanol dehydrogenase\",\n\"metabolites\":{\n\"fald_p\":1.0,\n\"ficytc_c\":-2.0,\n\"focytc_c\":2.0,\n\"h_p\":2.0,\n\"meoh_p\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"(CQW49_14425 and CQW49_14440) or CQW49_14395\"\n},\n{\n\"id\":\"PHYNS\",\n\"name\":\"phytoene synthase 1\",\n\"metabolites\":{\n\"ggdp_c\":-2.0,\n\"ppi_c\":1.0,\n\"prephyn_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_11740 or CQW49_03025\"\n},\n{\n\"id\":\"CDPGD\",\n\"name\":\"cdp glucose 4 6 dehydratase\",\n\"metabolites\":{\n\"cdpddglc_c\":1.0,\n\"cdpglc_c\":-1.0,\n\"h2o_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_16725\"\n},\n{\n\"id\":\"G2PP\",\n\"name\":\"glycerol 2 phosphatase\",\n\"metabolites\":{\n\"glyc2p_c\":-1.0,\n\"glyc_c\":1.0,\n\"h2o_c\":-1.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_01155\"\n},\n{\n\"id\":\"TRPS1r\",\n\"name\":\"tryptophan synthase\",\n\"metabolites\":{\n\"3ig3p_c\":-1.0,\n\"g3p_c\":1.0,\n\"h2o_c\":1.0,\n\"ser_L_c\":-1.0,\n\"trp_L_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_17140 and CQW49_15420\"\n},\n{\n\"id\":\"OPHBDC\",\n\"name\":\"3 octaprenyl 4 hydroxybenzoate carboxy lyase\",\n\"metabolites\":{\n\"2oph_c\":1.0,\n\"3ophb_c\":-1.0,\n\"co2_c\":1.0,\n\"h_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"ENCOAI41\",\n\"name\":\"enoyl CoA isomerase  n 4 0 \",\n\"metabolites\":{\n\"b2coa_c\":-1.0,\n\"vnaccoa_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_15495 and CQW49_15500\"\n},\n{\n\"id\":\"TSULtex\",\n\"name\":\"thiosulfate transport via diffusion  extracellular to periplasm \",\n\"metabolites\":{\n\"tsul_e\":-1.0,\n\"tsul_p\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"SORBNLDH\",\n\"name\":\"L sorbosone dehydrogenase\",\n\"metabolites\":{\n\"2dhguln_c\":1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"oxEA_c\":-1.0,\n\"rdEA_c\":1.0,\n\"sorbnl_L_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_09445\"\n},\n{\n\"id\":\"APG3PAT180\",\n\"name\":\"glycerol 3 phosphate synthetase  n 18 0 \",\n\"metabolites\":{\n\"1odecg3p_c\":1.0,\n\"glyc3p_c\":-1.0,\n\"ocdcap_c\":-1.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_01070\"\n},\n{\n\"id\":\"APG3PAT181\",\n\"name\":\"glycerol 3 phosphate synthetase  n 18 1 \",\n\"metabolites\":{\n\"1odec11eg3p_c\":1.0,\n\"glyc3p_c\":-1.0,\n\"ocdceap_c\":-1.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_01070\"\n},\n{\n\"id\":\"APH181\",\n\"name\":\"acylphosphatase  n 18 1 \",\n\"metabolites\":{\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"ocdcea_c\":1.0,\n\"ocdceap_c\":-1.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_04625\"\n},\n{\n\"id\":\"ACPpds\",\n\"name\":\"acyl carrier protein phosphodiesterase\",\n\"metabolites\":{\n\"ACP_c\":-1.0,\n\"apoACP_c\":1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"pan4p_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"EX_rib_D_e\",\n\"name\":\"exchange flux   D ribose\",\n\"metabolites\":{\n\"rib_D_e\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":0.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"CHORS\",\n\"name\":\"chorismate synthase\",\n\"metabolites\":{\n\"3psme_c\":-1.0,\n\"chor_c\":1.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_19465\"\n},\n{\n\"id\":\"APH180\",\n\"name\":\"acylphosphatase  n 18 0 \",\n\"metabolites\":{\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"ocdca_c\":1.0,\n\"ocdcap_c\":-1.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_04625\"\n},\n{\n\"id\":\"CHORM\",\n\"name\":\"chorismate mutase\",\n\"metabolites\":{\n\"chor_c\":-1.0,\n\"pphn_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"META1_0478\"\n},\n{\n\"id\":\"SUCOAS\",\n\"name\":\"succinyl CoA synthetase\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"coa_c\":-1.0,\n\"pi_c\":1.0,\n\"succ_c\":-1.0,\n\"succoa_c\":1.0\n},\n\"lower_bound\":0,\n\"upper_bound\":1000,\n\"gene_reaction_rule\":\"(CQW49_16385 or CQW49_18950) or (CQW49_12225 and CQW49_12220)\"\n},\n{\n\"id\":\"FACOAL80\",\n\"name\":\"fatty acyl CoA synthetase  n 8 0 \",\n\"metabolites\":{\n\"amp_c\":1.0,\n\"atp_c\":-1.0,\n\"coa_c\":-1.0,\n\"occoa_c\":1.0,\n\"octa_c\":-1.0,\n\"ppi_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_01835\"\n},\n{\n\"id\":\"5DGLCNR\",\n\"name\":\"5 keto D gluconate 5 reductase  inferred from physiology \",\n\"metabolites\":{\n\"5dglcn_c\":-1.0,\n\"glcn_c\":1.0,\n\"h_c\":-1.0,\n\"nadp_c\":1.0,\n\"nadph_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"PPDK\",\n\"name\":\"pyruvate phosphate dikinase\",\n\"metabolites\":{\n\"amp_c\":1.0,\n\"atp_c\":-1.0,\n\"h_c\":1.0,\n\"pep_c\":1.0,\n\"pi_c\":-1.0,\n\"ppi_c\":1.0,\n\"pyr_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_04520\"\n},\n{\n\"id\":\"BTCAL\",\n\"name\":\"fatty acyl CoA synthetase  n 4 0 \",\n\"metabolites\":{\n\"amp_c\":1.0,\n\"atp_c\":-1.0,\n\"btcoa_c\":1.0,\n\"but_c\":-1.0,\n\"coa_c\":-1.0,\n\"ppi_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_01835\"\n},\n{\n\"id\":\"H2MB4PRD\",\n\"name\":\"1 hydroxy 2 methyl 2  E  butenyl 4 diphosphate reductase 1\",\n\"metabolites\":{\n\"dmpp_c\":1.0,\n\"h2mb4p_c\":-1.0,\n\"h2o_c\":1.0,\n\"h_c\":-1.0,\n\"nadp_c\":1.0,\n\"nadph_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_17525\"\n},\n{\n\"id\":\"GTHS\",\n\"name\":\"glutathione synthetase\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"glucys_c\":-1.0,\n\"gly_c\":-1.0,\n\"gthrd_c\":1.0,\n\"h_c\":1.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":0,\n\"upper_bound\":1000,\n\"gene_reaction_rule\":\"CQW49_19395\"\n},\n{\n\"id\":\"XYLNTtex\",\n\"name\":\"D xylonate transport via diffusion  extracellular to periplasm \",\n\"metabolites\":{\n\"xylnt_D_e\":-1.0,\n\"xylnt_D_p\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"APH161\",\n\"name\":\"acylphosphatase  n 16 1 \",\n\"metabolites\":{\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"hdcea_c\":1.0,\n\"hdceap_c\":-1.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_04625\"\n},\n{\n\"id\":\"TRPS3r\",\n\"name\":\"tryptophan synthase A\",\n\"metabolites\":{\n\"3ig3p_c\":-1.0,\n\"g3p_c\":1.0,\n\"indole_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_15420\"\n},\n{\n\"id\":\"ADPT\",\n\"name\":\"adenine phosphoribosyltransferase\",\n\"metabolites\":{\n\"ade_c\":-1.0,\n\"amp_c\":1.0,\n\"ppi_c\":1.0,\n\"prpp_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_00270\"\n},\n{\n\"id\":\"EX_DM_trnatrp\",\n\"name\":\"exchange flux   tRNA Trp \",\n\"metabolites\":{\n\"trnatrp_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"CATetoh\",\n\"name\":\"catalase\",\n\"metabolites\":{\n\"acald_c\":1.0,\n\"etoh_c\":-1.0,\n\"h2o2_c\":-1.0,\n\"h2o_c\":2.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_09835\"\n},\n{\n\"id\":\"ACS\",\n\"name\":\"acetyl CoA synthetase\",\n\"metabolites\":{\n\"ac_c\":-1.0,\n\"accoa_c\":1.0,\n\"amp_c\":1.0,\n\"atp_c\":-1.0,\n\"coa_c\":-1.0,\n\"ppi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_20795 or CQW49_13835\"\n},\n{\n\"id\":\"MREDR\",\n\"name\":\"NADH azoreductase\",\n\"metabolites\":{\n\"Nndmetphenda_c\":1.0,\n\"anth_c\":1.0,\n\"h_c\":-2.0,\n\"mred_c\":-1.0,\n\"nad_c\":2.0,\n\"nadh_c\":-2.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_14780\"\n},\n{\n\"id\":\"PPPGO\",\n\"name\":\"protoporphyrinogen IX oxidase\",\n\"metabolites\":{\n\"h2o_c\":3.0,\n\"o2_c\":-1.5,\n\"ppp9_c\":1.0,\n\"pppg9_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"USHD\",\n\"name\":\"UDP 2 3 diacylglucosamine hydrolase\",\n\"metabolites\":{\n\"h2o_c\":-1.0,\n\"h_c\":2.0,\n\"lipidX_c\":1.0,\n\"u23ga_c\":-1.0,\n\"ump_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"ZCARDS\",\n\"name\":\"zeta carotene desaturase 1\",\n\"metabolites\":{\n\"h2o_c\":2.0,\n\"neuropn_c\":1.0,\n\"o2_c\":-1.0,\n\"oxEA_c\":1.0,\n\"rdEA_c\":-1.0,\n\"zcar_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"META1_3670\"\n},\n{\n\"id\":\"EX_ca2_e\",\n\"name\":\"exchange flux   calcium\",\n\"metabolites\":{\n\"ca2_e\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"APH160\",\n\"name\":\"acylphosphatase  n 16 0 \",\n\"metabolites\":{\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"hdca_c\":1.0,\n\"hdcap_c\":-1.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_04625\"\n},\n{\n\"id\":\"UAGAAT\",\n\"name\":\"UDP N acetylglucosamine acyltransferase\",\n\"metabolites\":{\n\"3hmrsACP_c\":-1.0,\n\"ACP_c\":1.0,\n\"u3aga_c\":1.0,\n\"uacgam_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_00480\"\n},\n{\n\"id\":\"CA2abctpp\",\n\"name\":\"calcium ABC transporter\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"ca2_c\":1.0,\n\"ca2_p\":-1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_03300\"\n},\n{\n\"id\":\"HSTPTr\",\n\"name\":\"histidinol phosphate aminotransferase\",\n\"metabolites\":{\n\"akg_c\":1.0,\n\"glu_L_c\":-1.0,\n\"hisp_c\":1.0,\n\"imacp_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_07145 or CQW49_08850\"\n},\n{\n\"id\":\"ZCARDS2_e\",\n\"name\":\"zeta carotene desaturase 2  extracellular \",\n\"metabolites\":{\n\"h2o_e\":2.0,\n\"neuropn_e\":-1.0,\n\"o2_e\":-1.0,\n\"oxEA_e\":1.0,\n\"rdEA_e\":-1.0,\n\"tlycopn_e\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_08235\"\n},\n{\n\"id\":\"EX_lald_L_e_\",\n\"name\":\"L lactaldehyde exchange\",\n\"metabolites\":{\n\"lald_L_e\":-1\n},\n\"lower_bound\":-1000,\n\"upper_bound\":1000,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"TRPTRS\",\n\"name\":\"tryptophanyl tRNA synthetase\",\n\"metabolites\":{\n\"amp_c\":1.0,\n\"atp_c\":-1.0,\n\"ppi_c\":1.0,\n\"trnatrp_c\":-1.0,\n\"trp_L_c\":-1.0,\n\"trptrna_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_04340\"\n},\n{\n\"id\":\"PROD2\",\n\"name\":\"proline dehydrogenase\",\n\"metabolites\":{\n\"1pyr5c_c\":1.0,\n\"fad_c\":-1.0,\n\"fadh2_c\":1.0,\n\"h_c\":1.0,\n\"pro_L_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_12965\"\n},\n{\n\"id\":\"DHORTS\",\n\"name\":\"dihydroorotase\",\n\"metabolites\":{\n\"cbasp_c\":-1.0,\n\"dhor_S_c\":1.0,\n\"h2o_c\":1.0,\n\"h_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_20500 or CQW49_02145\"\n},\n{\n\"id\":\"MOGDS\",\n\"name\":\"molybdopterin guanine dinucleotide synthase\",\n\"metabolites\":{\n\"gtp_c\":-1.0,\n\"h_c\":-1.0,\n\"moco_c\":-1.0,\n\"mocogdp_c\":1.0,\n\"ppi_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_12160 or CQW49_00915\"\n},\n{\n\"id\":\"EAR161y\",\n\"name\":\"enoyl  acyl carrier protein  reductase  n 16 1 \",\n\"metabolites\":{\n\"h_c\":-1.0,\n\"hdeACP_c\":1.0,\n\"nadp_c\":1.0,\n\"nadph_c\":-1.0,\n\"t3c9palmeACP_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_09320 or CQW49_16835\"\n},\n{\n\"id\":\"CYSTRS\",\n\"name\":\"cysteine tRNA synthetase\",\n\"metabolites\":{\n\"amp_c\":1.0,\n\"atp_c\":-1.0,\n\"cys_L_c\":-1.0,\n\"cystrna_c\":1.0,\n\"ppi_c\":1.0,\n\"trnacys_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_16420\"\n},\n{\n\"id\":\"3HAD121\",\n\"name\":\"3 hydroxyacyl  acyl carrier protein  dehydratase  n 12 1 \",\n\"metabolites\":{\n\"3hcddec5eACP_c\":-1.0,\n\"h2o_c\":1.0,\n\"t3c5ddeceACP_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_00475\"\n},\n{\n\"id\":\"3HAD120\",\n\"name\":\"3 hydroxyacyl  acyl carrier protein  dehydratase  n 12 0 \",\n\"metabolites\":{\n\"3hddecACP_c\":-1.0,\n\"h2o_c\":1.0,\n\"tddec2eACP_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_00475\"\n},\n{\n\"id\":\"IPMD2r\",\n\"name\":\"3 isopropylmalate dehydrogenase\",\n\"metabolites\":{\n\"3c3hmp_c\":-1.0,\n\"3c4mop_c\":1.0,\n\"h_c\":1.0,\n\"nad_c\":-1.0,\n\"nadh_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_18925\"\n},\n{\n\"id\":\"FCLPA\",\n\"name\":\"L fuculose 1 phosphate aldolase\",\n\"metabolites\":{\n\"dhap_c\":1.0,\n\"fc1p_c\":-1.0,\n\"lald_L_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_04400\"\n},\n{\n\"id\":\"EX_dca_e\",\n\"name\":\"exchange flux   decanoate\",\n\"metabolites\":{\n\"dca_e\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":0.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"COCHL\",\n\"name\":\"cobaltochelatase\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"co2dam_c\":1.0,\n\"cobalt2_c\":-1.0,\n\"h2o_c\":-1.0,\n\"h_c\":2.0,\n\"hgbam_c\":-1.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_09040 and CQW49_10210\"\n},\n{\n\"id\":\"CPPPGO\",\n\"name\":\"coproporphyrinogen III oxidase\",\n\"metabolites\":{\n\"co2_c\":2.0,\n\"cpppg3_c\":-1.0,\n\"h2o_c\":2.0,\n\"h_c\":4.0,\n\"o2_c\":-1.0,\n\"pppg9_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"META1_0498\"\n},\n{\n\"id\":\"EX_galcDarab_e\",\n\"name\":\"exchange flux   3 O b D galactopyranosyl D arabinose\",\n\"metabolites\":{\n\"galcDarab_e\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":0.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"HISTDADH\",\n\"name\":\"histidinal dehydrogenase\",\n\"metabolites\":{\n\"h2o_c\":-1.0,\n\"h_c\":2.0,\n\"his_L_c\":1.0,\n\"histda_c\":-1.0,\n\"nad_c\":-1.0,\n\"nadh_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_00600\"\n},\n{\n\"id\":\"EX_tsul_e\",\n\"name\":\"exchange flux   thiosulfate\",\n\"metabolites\":{\n\"tsul_e\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":0.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"ASPTA\",\n\"name\":\"aspartate aminotransferase\",\n\"metabolites\":{\n\"akg_c\":-1.0,\n\"asp_L_c\":-1.0,\n\"glu_L_c\":1.0,\n\"oaa_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_01260 or CQW49_14410\"\n},\n{\n\"id\":\"KAT141\",\n\"name\":\"3 ketoacyl CoA thiolase  n 14 1 \",\n\"metabolites\":{\n\"3octd7ecoa_c\":-1.0,\n\"accoa_c\":1.0,\n\"cdd5ecoa_c\":1.0,\n\"coa_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_15495 and CQW49_15500\"\n},\n{\n\"id\":\"TARTRtex\",\n\"name\":\"L tartrate transport via diffusion  extracellular to periplasm \",\n\"metabolites\":{\n\"tartr_L_e\":-1.0,\n\"tartr_L_p\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"PSD161\",\n\"name\":\"phosphatidylserine decarboxylase  n 16 1 \",\n\"metabolites\":{\n\"co2_c\":1.0,\n\"h_c\":-1.0,\n\"pe161_c\":1.0,\n\"ps161_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_03325\"\n},\n{\n\"id\":\"GLU5K\",\n\"name\":\"gamma glutamyl kinase\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"glu5p_c\":1.0,\n\"glu_L_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"(CQW49_02220 and CQW49_15675) or CQW49_02220\"\n},\n{\n\"id\":\"PSD160\",\n\"name\":\"phosphatidylserine decarboxylase  n 16 0 \",\n\"metabolites\":{\n\"co2_c\":1.0,\n\"h_c\":-1.0,\n\"pe160_c\":1.0,\n\"ps160_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_03325\"\n},\n{\n\"id\":\"TARTR_Ltpp\",\n\"name\":\"L tartrate transporter\",\n\"metabolites\":{\n\"h_c\":1.0,\n\"h_p\":-1.0,\n\"tartr_L_c\":1.0,\n\"tartr_L_p\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_12725\"\n},\n{\n\"id\":\"DXPS\",\n\"name\":\"1 deoxy D xylulose 5 phosphate synthase\",\n\"metabolites\":{\n\"co2_c\":1.0,\n\"dxyl5p_c\":1.0,\n\"g3p_c\":-1.0,\n\"h_c\":-1.0,\n\"pyr_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_09220\"\n},\n{\n\"id\":\"FACOAL121\",\n\"name\":\"fatty acyl CoA synthetase  n 12 1 \",\n\"metabolites\":{\n\"amp_c\":1.0,\n\"atp_c\":-1.0,\n\"cdd5ecoa_c\":1.0,\n\"coa_c\":-1.0,\n\"ddc5e_c\":-1.0,\n\"ppi_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_01835\"\n},\n{\n\"id\":\"FACOAL120\",\n\"name\":\"fatty acyl CoA synthetase  n 12 0 \",\n\"metabolites\":{\n\"amp_c\":1.0,\n\"atp_c\":-1.0,\n\"coa_c\":-1.0,\n\"ddca_c\":-1.0,\n\"ddcacoa_c\":1.0,\n\"ppi_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_01835\"\n},\n{\n\"id\":\"VALTRS\",\n\"name\":\"valine tRNA synthetase\",\n\"metabolites\":{\n\"amp_c\":1.0,\n\"atp_c\":-1.0,\n\"ppi_c\":1.0,\n\"val_L_c\":-1.0,\n\"valtrna_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_08630\"\n},\n{\n\"id\":\"EX_D_araba_e\",\n\"name\":\"exchange flux   D arabinonate\",\n\"metabolites\":{\n\"D_araba_e\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":0.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"PHAS\",\n\"name\":\"poly 3 hydroxyalkanoate  polymerase\",\n\"metabolites\":{\n\"coa_c\":1.0,\n\"pbhb_c\":1.0,\n\"r3hbcoa_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_10945\"\n},\n{\n\"id\":\"EX_mg2_e\",\n\"name\":\"exchange flux   magnesium\",\n\"metabolites\":{\n\"mg2_e\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"SUCCD1\",\n\"name\":\"succinate dehydrogenase\",\n\"metabolites\":{\n\"fum_c\":1.0,\n\"q_c\":-1.0,\n\"qh2_c\":1.0,\n\"succ_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"(CQW49_10805 or CQW49_22885) and CQW49_10810 and (CQW49_10825 or CQW49_22875) and CQW49_10800\"\n},\n{\n\"id\":\"MEPCT\",\n\"name\":\"4 diphosphocytidyl 2C  methyl D erythritol synthase\",\n\"metabolites\":{\n\"2me4p_c\":-1.0,\n\"4c2me_c\":1.0,\n\"ctp_c\":-1.0,\n\"h_c\":-1.0,\n\"ppi_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_01675\"\n},\n{\n\"id\":\"EX_lac_L_e\",\n\"name\":\"exchange flux    S  lactate\",\n\"metabolites\":{\n\"lac_L_e\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":0.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"METAT\",\n\"name\":\"methionine adenosyltransferase\",\n\"metabolites\":{\n\"amet_c\":1.0,\n\"atp_c\":-1.0,\n\"h2o_c\":-1.0,\n\"met_L_c\":-1.0,\n\"pi_c\":1.0,\n\"ppi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_04845\"\n},\n{\n\"id\":\"ETOHtex\",\n\"name\":\"ethanol transport via diffusion  extracellular to periplasm \",\n\"metabolites\":{\n\"etoh_e\":-1.0,\n\"etoh_p\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"3HAD100\",\n\"name\":\"B hydroxydecanoyl thioester dehydrase\",\n\"metabolites\":{\n\"3hdecACP_c\":-1.0,\n\"h2o_c\":1.0,\n\"tdec2eACP_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_00475 or CQW49_09310\"\n},\n{\n\"id\":\"FRDOr\",\n\"name\":\"NADPH ferredoxin oxidoreductase 1\",\n\"metabolites\":{\n\"fdxox_c\":-2.0,\n\"fdxrd_c\":2.0,\n\"h_c\":1.0,\n\"nadp_c\":1.0,\n\"nadph_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"META1_2334\"\n},\n{\n\"id\":\"THRTRS\",\n\"name\":\"threonine tRNA synthetase\",\n\"metabolites\":{\n\"amp_c\":1.0,\n\"atp_c\":-1.0,\n\"ppi_c\":1.0,\n\"thr_L_c\":-1.0,\n\"thrtrna_c\":1.0,\n\"trnathr_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_15975\"\n},\n{\n\"id\":\"EX_co2_e\",\n\"name\":\"exchange flux   CO2\",\n\"metabolites\":{\n\"co2_e\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"TMPPP\",\n\"name\":\"thiamine phosphate synthase\",\n\"metabolites\":{\n\"2mahmp_c\":-1.0,\n\"4mpetz_c\":-1.0,\n\"h_c\":-1.0,\n\"ppi_c\":1.0,\n\"thmmp_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_14255\"\n},\n{\n\"id\":\"KAT121\",\n\"name\":\"3 ketoacyl CoA thiolase  n 12 1 \",\n\"metabolites\":{\n\"3ocdd5ecoa_c\":-1.0,\n\"accoa_c\":1.0,\n\"cd3ecoa_c\":1.0,\n\"coa_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_15495 and CQW49_15500\"\n},\n{\n\"id\":\"HACDHG\",\n\"name\":\"haloacid dehalogenase\",\n\"metabolites\":{\n\"clac_c\":-1.0,\n\"glyclt_c\":1.0,\n\"h2o_c\":-1.0,\n\"hcl_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_00570\"\n},\n{\n\"id\":\"PRMICI\",\n\"name\":\"N  5  phospho L ribosyl formimino  5 amino 1  5  phosphoribosyl  4 imidazolecarboxamide isomerase\",\n\"metabolites\":{\n\"prfp_c\":-1.0,\n\"prlp_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_07615 or CQW49_13470\"\n},\n{\n\"id\":\"EX_araba_e\",\n\"name\":\"exchange flux   L arabinonate\",\n\"metabolites\":{\n\"araba_e\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":0.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"VALTA\",\n\"name\":\"amino acid transferase  valine \",\n\"metabolites\":{\n\"3mob_c\":-1.0,\n\"akg_c\":1.0,\n\"glu_L_c\":-1.0,\n\"val_L_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_02780\"\n},\n{\n\"id\":\"FCLT\",\n\"name\":\"ferrochelatase\",\n\"metabolites\":{\n\"fe2_c\":-1.0,\n\"h_c\":2.0,\n\"pheme_c\":1.0,\n\"ppp9_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_13530\"\n},\n{\n\"id\":\"PRFGS\",\n\"name\":\"phosphoribosylformylglycinamide synthetase\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"fgam_c\":-1.0,\n\"fpram_c\":1.0,\n\"gln_L_c\":-1.0,\n\"glu_L_c\":1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_11400 or CQW49_11920\"\n},\n{\n\"id\":\"MFPGS5\",\n\"name\":\"folylpolyglutamate synthase 1\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"glu_L_c\":-1.0,\n\"h_c\":1.0,\n\"mlthf5glu_c\":-1.0,\n\"mlthf6glu_c\":1.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_15430\"\n},\n{\n\"id\":\"TYRTA\",\n\"name\":\"aromatic amino acid transaminase  TYR \",\n\"metabolites\":{\n\"34hpp_c\":-1.0,\n\"akg_c\":1.0,\n\"glu_L_c\":-1.0,\n\"tyr_L_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_08850\"\n},\n{\n\"id\":\"T2DECAI\",\n\"name\":\"trans 2 decenoyl ACP isomerase\",\n\"metabolites\":{\n\"cdec3eACP_c\":1.0,\n\"tdec2eACP_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_09310\"\n},\n{\n\"id\":\"THMBIOS2\",\n\"name\":\"thiamin biosynthesis 2\",\n\"metabolites\":{\n\"ala_L_c\":1.0,\n\"cys_L_c\":-1.0,\n\"thil_c\":-1.0,\n\"thilps_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_01415\"\n},\n{\n\"id\":\"THMBIOS3\",\n\"name\":\"thiamin biosynthesis 3\",\n\"metabolites\":{\n\"amp_c\":1.0,\n\"thilps_c\":-1.0,\n\"thisamp_c\":-1.0,\n\"thisthilads_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"THMBIOS4\",\n\"name\":\"thiamin biosynthesis 4\",\n\"metabolites\":{\n\"thif_c\":-1.0,\n\"thil_c\":1.0,\n\"thisthifads_c\":1.0,\n\"thisthilads_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"PPCDC\",\n\"name\":\"phosphopantothenoylcysteine decarboxylase\",\n\"metabolites\":{\n\"4ppcys_c\":-1.0,\n\"co2_c\":1.0,\n\"h_c\":-1.0,\n\"pan4p_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_21235\"\n},\n{\n\"id\":\"FACOAL100\",\n\"name\":\"fatty acyl CoA synthetase  n 10 0 \",\n\"metabolites\":{\n\"amp_c\":1.0,\n\"atp_c\":-1.0,\n\"coa_c\":-1.0,\n\"dca_c\":-1.0,\n\"dcacoa_c\":1.0,\n\"ppi_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_01835\"\n},\n{\n\"id\":\"PPA2\",\n\"name\":\"triphosphate phosphohydrolase  inferred from gap \",\n\"metabolites\":{\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"pi_c\":1.0,\n\"ppi_c\":1.0,\n\"pppi_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"RPI\",\n\"name\":\"ribose 5 phosphate isomerase\",\n\"metabolites\":{\n\"r5p_c\":-1.0,\n\"ru5p_D_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_14240\"\n},\n{\n\"id\":\"DHXANTI\",\n\"name\":\"trans 2 3 dihydro 3 hydroxy anthranilate isomerase\",\n\"metabolites\":{\n\"23dh3hxanth_c\":1.0,\n\"t23dh3hxanth_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_06785\"\n},\n{\n\"id\":\"EX_DM_trnaphe\",\n\"name\":\"exchange flux   tRNA Phe \",\n\"metabolites\":{\n\"trnaphe_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"ORPT\",\n\"name\":\"orotate phosphoribosyltransferase\",\n\"metabolites\":{\n\"orot5p_c\":1.0,\n\"orot_c\":-1.0,\n\"ppi_c\":1.0,\n\"prpp_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_16180\"\n},\n{\n\"id\":\"DHXANTH\",\n\"name\":\"2 amino 2 deoxyisochorismate hydrolase\",\n\"metabolites\":{\n\"2ichor_c\":-1.0,\n\"h2o_c\":-1.0,\n\"pyr_c\":1.0,\n\"t23dh3hxanth_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"GMPS2\",\n\"name\":\"GMP synthetase\",\n\"metabolites\":{\n\"amp_c\":1.0,\n\"atp_c\":-1.0,\n\"gln_L_c\":-1.0,\n\"glu_L_c\":1.0,\n\"gmp_c\":1.0,\n\"h2o_c\":-1.0,\n\"h_c\":2.0,\n\"ppi_c\":1.0,\n\"xmp_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_20775\"\n},\n{\n\"id\":\"PYK\",\n\"name\":\"pyruvate kinase\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"h_c\":1.0,\n\"pep_c\":1.0,\n\"pyr_c\":-1.0\n},\n\"lower_bound\":-1000,\n\"upper_bound\":1000,\n\"gene_reaction_rule\":\"CQW49_01145\"\n},\n{\n\"id\":\"RPE\",\n\"name\":\"D ribulose 5 phosphate 3 epimerase\",\n\"metabolites\":{\n\"ru5p_D_c\":-1.0,\n\"xu5p_D_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_18385\"\n},\n{\n\"id\":\"PTA2\",\n\"name\":\"phosphate acetyltransferase 2\",\n\"metabolites\":{\n\"coa_c\":1.0,\n\"pi_c\":-1.0,\n\"ppap_c\":1.0,\n\"ppcoa_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_15770\"\n},\n{\n\"id\":\"ASAD\",\n\"name\":\"aspartate semialdehyde dehydrogenase\",\n\"metabolites\":{\n\"4pasp_c\":-1.0,\n\"aspsa_c\":1.0,\n\"h_c\":-1.0,\n\"nadp_c\":1.0,\n\"nadph_c\":-1.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_17770\"\n},\n{\n\"id\":\"ACPS1\",\n\"name\":\"holo  acyl carrier protein  synthase\",\n\"metabolites\":{\n\"ACP_c\":1.0,\n\"apoACP_c\":-1.0,\n\"coa_c\":-1.0,\n\"h_c\":1.0,\n\"pap_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_13435\"\n},\n{\n\"id\":\"FMNRx2\",\n\"name\":\"NADPH dependent FMN reductase\",\n\"metabolites\":{\n\"fmn_c\":1.0,\n\"fmnh2_c\":-1.0,\n\"h_c\":1.0,\n\"nadp_c\":-1.0,\n\"nadph_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"META2_0363 or META1_1214 or META1_4236 or (META1_2232 and META1_2233) or META1_3632 or META1_2380\"\n},\n{\n\"id\":\"HACOAEPI141\",\n\"name\":\"3 hydroxyacyl CoA epimerase  n 14 1 \",\n\"metabolites\":{\n\"3hctd7ecoa_c\":-1.0,\n\"R_3hctd7ecoa_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_15495 and CQW49_15500\"\n},\n{\n\"id\":\"BMMALCOAL\",\n\"name\":\"b methylmalyl CoA lyase\",\n\"metabolites\":{\n\"bmmalcoa_c\":-1.0,\n\"glx_c\":1.0,\n\"ppcoa_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_12235\"\n},\n{\n\"id\":\"EX_DM_thif\",\n\"name\":\"exchange flux   thiF\",\n\"metabolites\":{\n\"thif_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"PRAMPC\",\n\"name\":\"phosphoribosyl AMP cyclohydrolase\",\n\"metabolites\":{\n\"h2o_c\":-1.0,\n\"prbamp_c\":-1.0,\n\"prfp_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_20115\"\n},\n{\n\"id\":\"FUM\",\n\"name\":\"fumarate hydratase\",\n\"metabolites\":{\n\"fum_c\":-1.0,\n\"h2o_c\":-1.0,\n\"mal_L_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_13245\"\n},\n{\n\"id\":\"EX_fe2_e\",\n\"name\":\"exchange flux   Fe2 \",\n\"metabolites\":{\n\"fe2_e\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"EX_acac_e\",\n\"name\":\"exchange flux   acetoacetate\",\n\"metabolites\":{\n\"acac_e\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":0.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"EX_DM_thil\",\n\"name\":\"exchange flux   thiI\",\n\"metabolites\":{\n\"thil_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"KAT181\",\n\"name\":\"3 ketoacyl CoA thiolase  n 18 1 \",\n\"metabolites\":{\n\"3ococtd11ecoa_c\":-1.0,\n\"accoa_c\":1.0,\n\"coa_c\":-1.0,\n\"hdcoa_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_15495 and CQW49_15500\"\n},\n{\n\"id\":\"HGBAMS\",\n\"name\":\"hydrogenobyrinate a c diamide synthase\",\n\"metabolites\":{\n\"adp_c\":2.0,\n\"atp_c\":-2.0,\n\"gln_L_c\":-2.0,\n\"glu_L_c\":2.0,\n\"h2o_c\":-2.0,\n\"h_c\":3.0,\n\"hgbam_c\":1.0,\n\"hgbyr_c\":-1.0,\n\"pi_c\":2.0\n},\n\"lower_bound\":0,\n\"upper_bound\":1000,\n\"gene_reaction_rule\":\"CQW49_09625\"\n},\n{\n\"id\":\"DHDPRy\",\n\"name\":\"dihydrodipicolinate reductase\",\n\"metabolites\":{\n\"23dhdp_c\":-1.0,\n\"h_c\":-1.0,\n\"nadp_c\":1.0,\n\"nadph_c\":-1.0,\n\"thdp_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_21220\"\n},\n{\n\"id\":\"EX_DM_trnagln\",\n\"name\":\"exchange flux   tRNA Gln \",\n\"metabolites\":{\n\"trnagln_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"BRFAPS\",\n\"name\":\"4  b D ribofuranosyl aminobenzene 5  phosphate synthase\",\n\"metabolites\":{\n\"4abz_c\":-1.0,\n\"Brfap_c\":1.0,\n\"co2_c\":1.0,\n\"h_c\":-1.0,\n\"ppi_c\":1.0,\n\"prpp_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_10280\"\n},\n{\n\"id\":\"EX_DM_this\",\n\"name\":\"exchange flux   thiS\",\n\"metabolites\":{\n\"this_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"EX_ppa_e\",\n\"name\":\"exchange flux   propanoate\",\n\"metabolites\":{\n\"ppa_e\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":0.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"LPLIPAL1E181\",\n\"name\":\"lysophospholipase E1  n 18 1 \",\n\"metabolites\":{\n\"1agpe181_c\":-1.0,\n\"g3pe_c\":1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"ocdcea_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_20340\"\n},\n{\n\"id\":\"LEUTAi\",\n\"name\":\"amino acid transferase  leucine \",\n\"metabolites\":{\n\"4mop_c\":-1.0,\n\"akg_c\":1.0,\n\"glu_L_c\":-1.0,\n\"leu_L_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_02780\"\n},\n{\n\"id\":\"EX_DM_trnaglu\",\n\"name\":\"exchange flux   tRNA Glu \",\n\"metabolites\":{\n\"trnaglu_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"ACONT\",\n\"name\":\"aconitate hydratase\",\n\"metabolites\":{\n\"cit_c\":-1.0,\n\"icit_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_13135\"\n},\n{\n\"id\":\"EX_DM_trnagly\",\n\"name\":\"exchange flux   tRNA Gly \",\n\"metabolites\":{\n\"trnagly_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"FPGS10\",\n\"name\":\"folylpolyglutamate synthase 3\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"glu_L_c\":-1.0,\n\"h_c\":1.0,\n\"pi_c\":1.0,\n\"thf5glu_c\":-1.0,\n\"thf6glu_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_15430\"\n},\n{\n\"id\":\"ENCOAI162\",\n\"name\":\"enoyl CoA isomerase  n 16 1 \",\n\"metabolites\":{\n\"3chd9ecoa_c\":1.0,\n\"t2chd9ecoa_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_15495 and CQW49_15500\"\n},\n{\n\"id\":\"FACOAL161\",\n\"name\":\"fatty acyl CoA synthetase  n 16 1 \",\n\"metabolites\":{\n\"amp_c\":1.0,\n\"atp_c\":-1.0,\n\"coa_c\":-1.0,\n\"hdcea_c\":-1.0,\n\"hdcoa_c\":1.0,\n\"ppi_c\":1.0\n},\n\"lower_bound\":0,\n\"upper_bound\":1000,\n\"gene_reaction_rule\":\"CQW49_01835\"\n},\n{\n\"id\":\"ENCOAI161\",\n\"name\":\"enoyl CoA isomerase  n 16 0 \",\n\"metabolites\":{\n\"chd3ecoa_c\":1.0,\n\"hdd2coa_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_15495 and CQW49_15500\"\n},\n{\n\"id\":\"FACOAL160\",\n\"name\":\"fatty acyl CoA synthetase  n 16 0 \",\n\"metabolites\":{\n\"amp_c\":1.0,\n\"atp_c\":-1.0,\n\"coa_c\":-1.0,\n\"hdca_c\":-1.0,\n\"pmtcoa_c\":1.0,\n\"ppi_c\":1.0\n},\n\"lower_bound\":0,\n\"upper_bound\":1000,\n\"gene_reaction_rule\":\"CQW49_01835\"\n},\n{\n\"id\":\"NNDMBRT\",\n\"name\":\"nicotinate nucleotide  dimethylbenzimidazole phosphoribosyltransferase\",\n\"metabolites\":{\n\"5prdmbz_c\":1.0,\n\"dmbzid_c\":-1.0,\n\"h_c\":1.0,\n\"nac_c\":1.0,\n\"nicrnt_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_02435\"\n},\n{\n\"id\":\"ALAR\",\n\"name\":\"alanine racemase\",\n\"metabolites\":{\n\"ala_D_c\":1.0,\n\"ala_L_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_10790 or CQW49_10530\"\n},\n{\n\"id\":\"ALAS\",\n\"name\":\"5 aminolevulinate synthase\",\n\"metabolites\":{\n\"5aop_c\":1.0,\n\"co2_c\":1.0,\n\"coa_c\":1.0,\n\"gly_c\":-1.0,\n\"h_c\":-1.0,\n\"succoa_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_19185\"\n},\n{\n\"id\":\"ORNDC\",\n\"name\":\"ornithine decarboxylase\",\n\"metabolites\":{\n\"co2_c\":1.0,\n\"h_c\":-1.0,\n\"orn_c\":-1.0,\n\"ptrc_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_06695\"\n},\n{\n\"id\":\"NADK\",\n\"name\":\"NAD kinase\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"h_c\":1.0,\n\"nad_c\":-1.0,\n\"nadp_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_09060\"\n},\n{\n\"id\":\"EX_cu2_e\",\n\"name\":\"exchange flux   copper\",\n\"metabolites\":{\n\"cu2_e\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"DBTSr\",\n\"name\":\"dethiobiotin synthetase\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"co2_c\":-1.0,\n\"dann_c\":-1.0,\n\"dtbt_c\":1.0,\n\"h_c\":3.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_01850\"\n},\n{\n\"id\":\"GLUtex\",\n\"name\":\"glutamate transport via diffusion  extracellular to periplasm \",\n\"metabolites\":{\n\"glu_L_e\":-1.0,\n\"glu_L_p\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"HACOAEPI121\",\n\"name\":\"3 hydroxyacyl CoA epimerase  n 12 1 \",\n\"metabolites\":{\n\"3hcdd5ecoa_c\":-1.0,\n\"R_3hcdd5ecoa_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_15495 and CQW49_15500\"\n},\n{\n\"id\":\"GAPD\",\n\"name\":\"glyceraldehyde 3 phosphate dehydrogenase\",\n\"metabolites\":{\n\"13dpg_c\":1.0,\n\"g3p_c\":-1.0,\n\"h_c\":1.0,\n\"nad_c\":-1.0,\n\"nadh_c\":1.0,\n\"pi_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_11885\"\n},\n{\n\"id\":\"CU2abcpp\",\n\"name\":\"copper exporting ATPase\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"cu2_c\":-1.0,\n\"cu2_p\":1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_04960\"\n},\n{\n\"id\":\"KDOPS\",\n\"name\":\"3 deoxy 8 phosphooctulonate synthase\",\n\"metabolites\":{\n\"ara5p_c\":-1.0,\n\"h2o_c\":-1.0,\n\"kdo8p_c\":1.0,\n\"pep_c\":-1.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_11725\"\n},\n{\n\"id\":\"GLYAMDTRc\",\n\"name\":\"glycine amidinotransferase\",\n\"metabolites\":{\n\"arg_L_c\":-1.0,\n\"gly_c\":-1.0,\n\"gudac_c\":1.0,\n\"orn_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_05080\"\n},\n{\n\"id\":\"UPP3S\",\n\"name\":\"uroporphyrinogen III synthase\",\n\"metabolites\":{\n\"h2o_c\":1.0,\n\"hmbil_c\":-1.0,\n\"uppg3_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_06510\"\n},\n{\n\"id\":\"UPP3MT\",\n\"name\":\"uroporphyrin III C methyltransferase 1\",\n\"metabolites\":{\n\"ahcys_c\":1.0,\n\"amet_c\":-1.0,\n\"h_c\":1.0,\n\"pre1_c\":1.0,\n\"uppg3_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_21195\"\n},\n{\n\"id\":\"KDOPP\",\n\"name\":\"3 deoxy D manno octulosonate 8 phosphate phosphatase\",\n\"metabolites\":{\n\"h2o_c\":-1.0,\n\"kdo8p_c\":-1.0,\n\"kdo_c\":1.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"THD2pp\",\n\"name\":\"NAD P  transhydrogenase\",\n\"metabolites\":{\n\"h_c\":1.0,\n\"h_p\":-1.0,\n\"nad_c\":1.0,\n\"nadh_c\":-1.0,\n\"nadp_c\":-1.0,\n\"nadph_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"(CQW49_13075 or CQW49_13080) and CQW49_13070\"\n},\n{\n\"id\":\"EX_so4_e\",\n\"name\":\"exchange flux   SO42 \",\n\"metabolites\":{\n\"so4_e\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"ETHMALCOAM\",\n\"name\":\"ethylmalonyl CoA mutase\",\n\"metabolites\":{\n\"2Rethmalcoa_c\":-1.0,\n\"2Smsucccoa_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_20150\"\n},\n{\n\"id\":\"LPLIPAL1E160\",\n\"name\":\"lysophospholipase E1  n 16 0 \",\n\"metabolites\":{\n\"1agpe160_c\":-1.0,\n\"g3pe_c\":1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"hdca_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_20340\"\n},\n{\n\"id\":\"LPLIPAL1E161\",\n\"name\":\"lysophospholipase E1  n 16 1 \",\n\"metabolites\":{\n\"1agpe161_c\":-1.0,\n\"g3pe_c\":1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"hdcea_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_20340\"\n},\n{\n\"id\":\"KAT161\",\n\"name\":\"3 ketoacyl CoA thiolase  n 16 1 \",\n\"metabolites\":{\n\"3ochd9ecoa_c\":-1.0,\n\"accoa_c\":1.0,\n\"coa_c\":-1.0,\n\"tdecoa_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_15495 and CQW49_15500\"\n},\n{\n\"id\":\"HSK\",\n\"name\":\"homoserine kinase\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"h_c\":1.0,\n\"hom_L_c\":-1.0,\n\"phom_c\":1.0\n},\n\"lower_bound\":0,\n\"upper_bound\":1000,\n\"gene_reaction_rule\":\"CQW49_17520\"\n},\n{\n\"id\":\"EX_glyclt_e\",\n\"name\":\"exchange flux   glycolate\",\n\"metabolites\":{\n\"glyclt_e\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":0.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"MLMPTDHy\",\n\"name\":\"methylenetetrahydromethanopterin dehydrogenase 1\",\n\"metabolites\":{\n\"meh4mpt_c\":1.0,\n\"mlh4mpt_c\":-1.0,\n\"nadp_c\":-1.0,\n\"nadph_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_13850 or CQW49_12210\"\n},\n{\n\"id\":\"PHBD2\",\n\"name\":\"poly 3 hydroxyalkanoate  depolymerase\",\n\"metabolites\":{\n\"bhb_c\":1.0,\n\"h2o_c\":-1.0,\n\"pbhb_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_06220 or CQW49_16675\"\n},\n{\n\"id\":\"ENCOAI182\",\n\"name\":\"enoyl CoA isomerase  n 18 1 \",\n\"metabolites\":{\n\"3coctd11ecoa_c\":1.0,\n\"t2coctd11ecoa_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_15495 and CQW49_15500\"\n},\n{\n\"id\":\"FACOAL141\",\n\"name\":\"fatty acyl CoA synthetase  n 14 1 \",\n\"metabolites\":{\n\"amp_c\":1.0,\n\"atp_c\":-1.0,\n\"coa_c\":-1.0,\n\"ppi_c\":1.0,\n\"tdecoa_c\":1.0,\n\"ttdcea_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_01835\"\n},\n{\n\"id\":\"ENCOAI181\",\n\"name\":\"enoyl CoA isomerase  n 18 0 \",\n\"metabolites\":{\n\"coctd3ecoa_c\":1.0,\n\"od2coa_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_15495 and CQW49_15500\"\n},\n{\n\"id\":\"FRTT\",\n\"name\":\"geranylgeranyl pyrophosphate synthase\",\n\"metabolites\":{\n\"frdp_c\":-1.0,\n\"ggdp_c\":1.0,\n\"ipdp_c\":-1.0,\n\"ppi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_18820\"\n},\n{\n\"id\":\"FACOAL140\",\n\"name\":\"fatty acyl CoA synthetase  n 14 0 \",\n\"metabolites\":{\n\"amp_c\":1.0,\n\"atp_c\":-1.0,\n\"coa_c\":-1.0,\n\"ppi_c\":1.0,\n\"tdcoa_c\":1.0,\n\"ttdca_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_01835\"\n},\n{\n\"id\":\"ASP1DC\",\n\"name\":\"aspartate 1 decarboxylase\",\n\"metabolites\":{\n\"ala_B_c\":1.0,\n\"asp_L_c\":-1.0,\n\"co2_c\":1.0,\n\"h_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"DHQS\",\n\"name\":\"3 dehydroquinate synthase\",\n\"metabolites\":{\n\"2dda7p_c\":-1.0,\n\"3dhq_c\":1.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_06775\"\n},\n{\n\"id\":\"CBPS\",\n\"name\":\"carbamoyl phosphate synthetase\",\n\"metabolites\":{\n\"adp_c\":2.0,\n\"atp_c\":-2.0,\n\"cbp_c\":1.0,\n\"gln_L_c\":-1.0,\n\"glu_L_c\":1.0,\n\"h2o_c\":-1.0,\n\"h_c\":2.0,\n\"hco3_c\":-1.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":0,\n\"upper_bound\":1000,\n\"gene_reaction_rule\":\"CQW49_11955 and CQW49_10590\"\n},\n{\n\"id\":\"LDH_L\",\n\"name\":\"S lactate dehydrogenase\",\n\"metabolites\":{\n\"h_c\":1.0,\n\"lac_L_c\":-1.0,\n\"nad_c\":-1.0,\n\"nadh_c\":1.0,\n\"pyr_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"ETHAtex\",\n\"name\":\"ethanolamine transport via diffusion  extracellular to periplasm \",\n\"metabolites\":{\n\"etha_e\":-1.0,\n\"etha_p\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"THZS\",\n\"name\":\"thiazole synthase 1\",\n\"metabolites\":{\n\"4mpetz_c\":1.0,\n\"imgly_c\":-1.0,\n\"thif_c\":1.0,\n\"this_c\":1.0,\n\"thisthifads_c\":-1.0,\n\"tyr_L_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_14260\"\n},\n{\n\"id\":\"DNMPPA\",\n\"name\":\"dihydroneopterin monophosphate dephosphorylase\",\n\"metabolites\":{\n\"dhnpt_c\":1.0,\n\"dhpmp_c\":-1.0,\n\"h2o_c\":-1.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"EX_mobd_e\",\n\"name\":\"exchange flux   molybdate\",\n\"metabolites\":{\n\"mobd_e\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"DHQD\",\n\"name\":\"3 dehydroquinate dehydratase\",\n\"metabolites\":{\n\"3dhq_c\":-1.0,\n\"3dhsk_c\":1.0,\n\"h2o_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_05025\"\n},\n{\n\"id\":\"CLt4\",\n\"name\":\"chloride channel\",\n\"metabolites\":{\n\"cl_c\":1.0,\n\"cl_p\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_13815\"\n},\n{\n\"id\":\"GLYTRS\",\n\"name\":\"glycine tRNA synthetase\",\n\"metabolites\":{\n\"amp_c\":1.0,\n\"atp_c\":-1.0,\n\"gly_c\":-1.0,\n\"glytrna_c\":1.0,\n\"ppi_c\":1.0,\n\"trnagly_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_10565 and CQW49_20945\"\n},\n{\n\"id\":\"Kabcpp\",\n\"name\":\"potassium transporting ATPase\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"k_c\":1.0,\n\"k_p\":-1.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_10620 and CQW49_10625 and CQW49_10630\"\n},\n{\n\"id\":\"PPAt7\",\n\"name\":\"propanoate symport  periplasm to cytoplasm \",\n\"metabolites\":{\n\"h_c\":1.0,\n\"h_p\":-1.0,\n\"ppa_c\":1.0,\n\"ppa_p\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"MALDHDC\",\n\"name\":\"malate dehydrogenase  decarboxylating \",\n\"metabolites\":{\n\"co2_c\":1.0,\n\"mal_L_c\":-1.0,\n\"nad_c\":-1.0,\n\"nadh_c\":1.0,\n\"pyr_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_10910\"\n},\n{\n\"id\":\"HNEUROPNS2\",\n\"name\":\"hydroxyneurosporene synthase 2\",\n\"metabolites\":{\n\"anrdvbin_c\":-1.0,\n\"h2o_c\":-1.0,\n\"rdvbin_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"META1_2922\"\n},\n{\n\"id\":\"EX_dha_e\",\n\"name\":\"exchange flux   glycerone\",\n\"metabolites\":{\n\"dha_e\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":0.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"HNEUROPNS1\",\n\"name\":\"hydroxyneurosporene synthase 1\",\n\"metabolites\":{\n\"h2o_c\":-1.0,\n\"rdpin_c\":1.0,\n\"tlycopn_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"META1_2922\"\n},\n{\n\"id\":\"ACPPAT181\",\n\"name\":\"acyl phosphate synthase  n 18 1 \",\n\"metabolites\":{\n\"ACP_c\":1.0,\n\"ocdceap_c\":1.0,\n\"octeACP_c\":-1.0,\n\"pi_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_03725\"\n},\n{\n\"id\":\"UAAGDS\",\n\"name\":\"UDP N acetylmuramoylalanyl D glutamate 2 6 diaminopimelate ligase\",\n\"metabolites\":{\n\"26dap_M_c\":-1.0,\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"h_c\":1.0,\n\"pi_c\":1.0,\n\"uamag_c\":-1.0,\n\"ugmd_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_11205\"\n},\n{\n\"id\":\"SDPDS\",\n\"name\":\"N succinyl L diaminopimelate desuccinylase\",\n\"metabolites\":{\n\"26dap_LL_c\":1.0,\n\"h2o_c\":-1.0,\n\"sl26da_c\":-1.0,\n\"succ_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_09480\"\n},\n{\n\"id\":\"HACOAEPI181\",\n\"name\":\"3 hydroxyacyl CoA epimerase  n 18 1 \",\n\"metabolites\":{\n\"3hcoctd11ecoa_c\":-1.0,\n\"R_3hcoctd11ecoa_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_15495 and CQW49_15500\"\n},\n{\n\"id\":\"MCPST\",\n\"name\":\"3 mercaptopyruvate sulfurtransferase\",\n\"metabolites\":{\n\"cyan_c\":-1.0,\n\"h_c\":1.0,\n\"mercppyr_c\":-1.0,\n\"pyr_c\":1.0,\n\"tcynt_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_20680\"\n},\n{\n\"id\":\"ACPPAT180\",\n\"name\":\"acyl phosphate synthase  n 18 0 \",\n\"metabolites\":{\n\"ACP_c\":1.0,\n\"ocdcaACP_c\":-1.0,\n\"ocdcap_c\":1.0,\n\"pi_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_03725\"\n},\n{\n\"id\":\"AIRCr\",\n\"name\":\"phosphoribosylaminoimidazole carboxylase\",\n\"metabolites\":{\n\"5aizc_c\":1.0,\n\"air_c\":-1.0,\n\"co2_c\":-1.0,\n\"h_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_20925 and CQW49_20930\"\n},\n{\n\"id\":\"IG3PS\",\n\"name\":\"imidazole glycerol phosphate synthase\",\n\"metabolites\":{\n\"aicar_c\":1.0,\n\"eig3p_c\":1.0,\n\"gln_L_c\":-1.0,\n\"glu_L_c\":1.0,\n\"h_c\":1.0,\n\"prlp_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_07610 and CQW49_07630\"\n},\n{\n\"id\":\"MOBDtex\",\n\"name\":\"molybdate transport via diffusion  extracellular to periplasm \",\n\"metabolites\":{\n\"mobd_e\":-1.0,\n\"mobd_p\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"GLYCLTtex\",\n\"name\":\"glycolate transport via diffusion  extracellular to periplasm \",\n\"metabolites\":{\n\"glyclt_e\":-1.0,\n\"glyclt_p\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"ACOTA\",\n\"name\":\"acetylornithine aminotransferase\",\n\"metabolites\":{\n\"acg5sa_c\":1.0,\n\"acorn_c\":-1.0,\n\"akg_c\":-1.0,\n\"glu_L_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_13060\"\n},\n{\n\"id\":\"TMDS\",\n\"name\":\"thymidylate synthetase\",\n\"metabolites\":{\n\"dhf_c\":1.0,\n\"dtmp_c\":1.0,\n\"dump_c\":-1.0,\n\"mlthf_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"META1_2853\"\n},\n{\n\"id\":\"PRAIS\",\n\"name\":\"phosphoribosylaminoimidazole synthetase\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"air_c\":1.0,\n\"atp_c\":-1.0,\n\"fpram_c\":-1.0,\n\"h_c\":2.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_01375\"\n},\n{\n\"id\":\"ANACMURLALAA\",\n\"name\":\"anhydro N acetylmuramoyl L alanine amidase\",\n\"metabolites\":{\n\"GlcNacanhMurNacAlagGlucDAPAla_c\":-1.0,\n\"GlcNacanhMurNac_c\":1.0,\n\"alagDgluDAPDala_c\":1.0,\n\"h2o_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_11775\"\n},\n{\n\"id\":\"UPPDC1\",\n\"name\":\"uroporphyrinogen decarboxylase\",\n\"metabolites\":{\n\"co2_c\":4.0,\n\"cpppg3_c\":1.0,\n\"h_c\":-4.0,\n\"uppg3_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_12785\"\n},\n{\n\"id\":\"ARABA_Dtex\",\n\"name\":\"D arabinonate transport via diffusion  extracellular to periplasm \",\n\"metabolites\":{\n\"D_araba_e\":-1.0,\n\"D_araba_p\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"EX_arab_D_e\",\n\"name\":\"exchange flux   D arabinose\",\n\"metabolites\":{\n\"arab_D_e\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":0.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"SPOTN\",\n\"name\":\"1 amino propan 2 one 3 phosphate synthesis\",\n\"metabolites\":{\n\"3a2op_c\":1.0,\n\"ao4pob_c\":-1.0,\n\"co2_c\":1.0,\n\"h_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"SP0001\"\n},\n{\n\"id\":\"3OAR40\",\n\"name\":\"3 oxoacyl  acyl carrier protein  reductase  n 4 0 \",\n\"metabolites\":{\n\"R_3hbacp_c\":1.0,\n\"actACP_c\":-1.0,\n\"h_c\":-1.0,\n\"nadp_c\":1.0,\n\"nadph_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_16140 or CQW49_17680\"\n},\n{\n\"id\":\"XYLtex\",\n\"name\":\"D xylose transport via diffusion  extracellular to periplasm \",\n\"metabolites\":{\n\"xyl_D_e\":-1.0,\n\"xyl_D_p\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"SSALyr\",\n\"name\":\"succinate semialdehyde dehydrogenase\",\n\"metabolites\":{\n\"h2o_c\":-1.0,\n\"h_c\":2.0,\n\"nadp_c\":-1.0,\n\"nadph_c\":1.0,\n\"succ_c\":1.0,\n\"sucsal_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_06105\"\n},\n{\n\"id\":\"UDPGDr\",\n\"name\":\"UDP glucose 6 dehydrogenase\",\n\"metabolites\":{\n\"h2o_c\":-1.0,\n\"h_c\":3.0,\n\"nad_c\":-2.0,\n\"nadh_c\":2.0,\n\"udpg_c\":-1.0,\n\"udpglcur_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_11720\"\n},\n{\n\"id\":\"DTPCUDCPPP\",\n\"name\":\"undecaprenyl pyrophosphate phosphatase\",\n\"metabolites\":{\n\"dtpcudcpp_c\":-1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"pi_c\":1.0,\n\"udcpp_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_04285\"\n},\n{\n\"id\":\"PPC\",\n\"name\":\"phosphoenolpyruvate carboxylase\",\n\"metabolites\":{\n\"co2_c\":-1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"oaa_c\":1.0,\n\"pep_c\":-1.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_05095 or CQW49_12230\"\n},\n{\n\"id\":\"PPA\",\n\"name\":\"inorganic pyrophosphatase\",\n\"metabolites\":{\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"pi_c\":2.0,\n\"ppi_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_04295\"\n},\n{\n\"id\":\"BTCOAC\",\n\"name\":\"butyryl CoA carboxylase\",\n\"metabolites\":{\n\"2Sethmalcoa_c\":1.0,\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"btcoa_c\":-1.0,\n\"h_c\":1.0,\n\"hco3_c\":-1.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_20805 and CQW49_16085\"\n},\n{\n\"id\":\"3HAD181\",\n\"name\":\"3 hydroxyacyl  acyl carrier protein  dehydratase  n 18 1 \",\n\"metabolites\":{\n\"3hcvac11eACP_c\":-1.0,\n\"h2o_c\":1.0,\n\"t3c11vaceACP_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_00475\"\n},\n{\n\"id\":\"PPDODH\",\n\"name\":\"1 2 propanediol dehydrogenase\",\n\"metabolites\":{\n\"12ppd_S_p\":-1.0,\n\"ficytc_c\":-4.0,\n\"focytc_c\":4.0,\n\"h_p\":2.0,\n\"lald_L_p\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_14425 and CQW49_14440\"\n},\n{\n\"id\":\"3HAD180\",\n\"name\":\"3 hydroxyacyl  acyl carrier protein  dehydratase  n 18 0 \",\n\"metabolites\":{\n\"3hoctaACP_c\":-1.0,\n\"h2o_c\":1.0,\n\"toctd2eACP_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_00475\"\n},\n{\n\"id\":\"ACPPAT161\",\n\"name\":\"acyl phosphate synthase  n 16 1 \",\n\"metabolites\":{\n\"ACP_c\":1.0,\n\"hdceap_c\":1.0,\n\"hdeACP_c\":-1.0,\n\"pi_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_03725\"\n},\n{\n\"id\":\"ACPPAT160\",\n\"name\":\"acyl phosphate synthase  n 16 0 \",\n\"metabolites\":{\n\"ACP_c\":1.0,\n\"hdcap_c\":1.0,\n\"palmACP_c\":-1.0,\n\"pi_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_03725\"\n},\n{\n\"id\":\"HACOAEPI161\",\n\"name\":\"3 hydroxyacyl CoA epimerase  n 16 1 \",\n\"metabolites\":{\n\"3hchd9ecoa_c\":-1.0,\n\"R_3hchd9ecoa_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_15495 and CQW49_15500\"\n},\n{\n\"id\":\"MLMPTDH\",\n\"name\":\"methylenetetrahydromethanopterin dehydrogenase 2\",\n\"metabolites\":{\n\"meh4mpt_c\":1.0,\n\"mlh4mpt_c\":-1.0,\n\"nad_c\":-1.0,\n\"nadh_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_13850 or CQW49_12210\"\n},\n{\n\"id\":\"PRAI\",\n\"name\":\"phosphoribosylanthranilate isomerase\",\n\"metabolites\":{\n\"2cpr5p_c\":1.0,\n\"pran_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_17130\"\n},\n{\n\"id\":\"CBLAT\",\n\"name\":\"cobalamin adenosyltransferase\",\n\"metabolites\":{\n\"adocbl_c\":1.0,\n\"atp_c\":-1.0,\n\"cbl1_c\":-1.0,\n\"h_c\":-1.0,\n\"pppi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_17855\"\n},\n{\n\"id\":\"DPCOAK\",\n\"name\":\"dephospho CoA kinase\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"coa_c\":1.0,\n\"dpcoa_c\":-1.0,\n\"h_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_12795\"\n},\n{\n\"id\":\"FTHFL\",\n\"name\":\"formate tetrahydrofolate ligase\",\n\"metabolites\":{\n\"10fthf_c\":1.0,\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"for_c\":-1.0,\n\"pi_c\":1.0,\n\"thf_c\":-1.0\n},\n\"lower_bound\":0,\n\"upper_bound\":1000,\n\"gene_reaction_rule\":\"CQW49_12195\"\n},\n{\n\"id\":\"EX_akg_e\",\n\"name\":\"exchange flux   2 oxoglutarate\",\n\"metabolites\":{\n\"akg_e\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":0.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"ILETRS\",\n\"name\":\"isoleucine tRNA synthetase\",\n\"metabolites\":{\n\"amp_c\":1.0,\n\"atp_c\":-1.0,\n\"ile_L_c\":-1.0,\n\"iletrna_c\":1.0,\n\"ppi_c\":1.0,\n\"trnaile_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_20420\"\n},\n{\n\"id\":\"ASPO6\",\n\"name\":\"L aspartate oxidase\",\n\"metabolites\":{\n\"asp_L_c\":-1.0,\n\"h2o2_c\":1.0,\n\"h_c\":1.0,\n\"iasp_c\":1.0,\n\"o2_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_10310\"\n},\n{\n\"id\":\"PRE5MT\",\n\"name\":\"precorrin 5  C1  methyltransferase\",\n\"metabolites\":{\n\"ac_c\":1.0,\n\"ahcys_c\":1.0,\n\"amet_c\":-1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"pre5_c\":-1.0,\n\"pre6a_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_09630\"\n},\n{\n\"id\":\"FACOAL180\",\n\"name\":\"fatty acyl CoA synthetase  n 18 0 \",\n\"metabolites\":{\n\"amp_c\":1.0,\n\"atp_c\":-1.0,\n\"coa_c\":-1.0,\n\"ocdca_c\":-1.0,\n\"ppi_c\":1.0,\n\"stcoa_c\":1.0\n},\n\"lower_bound\":0,\n\"upper_bound\":1000,\n\"gene_reaction_rule\":\"CQW49_01835\"\n},\n{\n\"id\":\"FACOAL181\",\n\"name\":\"fatty acyl CoA synthetase  n 18 1 \",\n\"metabolites\":{\n\"amp_c\":1.0,\n\"atp_c\":-1.0,\n\"coa_c\":-1.0,\n\"ocdcea_c\":-1.0,\n\"odecoa_c\":1.0,\n\"ppi_c\":1.0\n},\n\"lower_bound\":0,\n\"upper_bound\":1000,\n\"gene_reaction_rule\":\"CQW49_01835\"\n},\n{\n\"id\":\"FALDHp\",\n\"name\":\"formaldehyde dehydrogenase\",\n\"metabolites\":{\n\"fald_p\":-1.0,\n\"ficytc_c\":-2.0,\n\"focytc_c\":2.0,\n\"for_p\":1.0,\n\"h2o_p\":-1.0,\n\"h_p\":3.0\n},\n\"lower_bound\":0,\n\"upper_bound\":0,\n\"gene_reaction_rule\":\"CQW49_14395\"\n},\n{\n\"id\":\"TRSARr\",\n\"name\":\"2 hydroxy 3 oxopropionate reductase  NAD \",\n\"metabolites\":{\n\"2h3oppan_c\":1.0,\n\"glyc_R_c\":-1.0,\n\"h_c\":1.0,\n\"nad_c\":-1.0,\n\"nadh_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_20380\"\n},\n{\n\"id\":\"DHOANTC\",\n\"name\":\"2 3 dihydro 3 oxo anthranilate condensation  hypothetical \",\n\"metabolites\":{\n\"23dh3oxanth_c\":-2.0,\n\"co2_c\":1.0,\n\"h_c\":7.0,\n\"o2_c\":1.0,\n\"phez1c_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"PRBK\",\n\"name\":\"phosphoribulokinase\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"h_c\":1.0,\n\"rb15bp_c\":1.0,\n\"ru5p_D_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_18405\"\n},\n{\n\"id\":\"LPLIP2AGPC160\",\n\"name\":\"lysophospholipase C2  n 16 0 \",\n\"metabolites\":{\n\"2agpc160_c\":-1.0,\n\"g3pc_c\":1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"hdca_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_20340\"\n},\n{\n\"id\":\"DHFS\",\n\"name\":\"dihydrofolate synthetase 1\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"dhf_c\":1.0,\n\"dhpt_c\":-1.0,\n\"glu_L_c\":-1.0,\n\"h_c\":1.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_15430\"\n},\n{\n\"id\":\"PGPP160\",\n\"name\":\"phosphatidylglycerophosphatase  n 16 0 \",\n\"metabolites\":{\n\"h2o_c\":-1.0,\n\"pg160_c\":1.0,\n\"pgp160_c\":-1.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"DHFR\",\n\"name\":\"dihydrofolate reductase\",\n\"metabolites\":{\n\"dhf_c\":-1.0,\n\"h_c\":-1.0,\n\"nadp_c\":1.0,\n\"nadph_c\":-1.0,\n\"thf_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_20290\"\n},\n{\n\"id\":\"EX_meoh_e\",\n\"name\":\"exchange flux   methanol\",\n\"metabolites\":{\n\"meoh_e\":-1.0\n},\n\"lower_bound\":0,\n\"upper_bound\":0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"PGPP161\",\n\"name\":\"phosphatidylglycerophosphatase  n 16 1 \",\n\"metabolites\":{\n\"h2o_c\":-1.0,\n\"pg161_c\":1.0,\n\"pgp161_c\":-1.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"3HAD160\",\n\"name\":\"3 hydroxyacyl  acyl carrier protein  dehydratase  n 16 0 \",\n\"metabolites\":{\n\"3hpalmACP_c\":-1.0,\n\"h2o_c\":1.0,\n\"tpalm2eACP_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_00475\"\n},\n{\n\"id\":\"3HAD161\",\n\"name\":\"3 hydroxyacyl  acyl carrier protein  dehydratase  n 16 1 \",\n\"metabolites\":{\n\"3hcpalm9eACP_c\":-1.0,\n\"h2o_c\":1.0,\n\"t3c9palmeACP_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_00475\"\n},\n{\n\"id\":\"LGTHL\",\n\"name\":\"lactoylglutathione 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oxoacyl  acyl carrier protein  reductase  n 8 0 \",\n\"metabolites\":{\n\"3hoctACP_c\":1.0,\n\"3ooctACP_c\":-1.0,\n\"h_c\":-1.0,\n\"nadp_c\":1.0,\n\"nadph_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_16140 or CQW49_17680\"\n},\n{\n\"id\":\"METTRS\",\n\"name\":\"methionyl tRNA synthetase\",\n\"metabolites\":{\n\"amp_c\":1.0,\n\"atp_c\":-1.0,\n\"met_L_c\":-1.0,\n\"mettrna_c\":1.0,\n\"ppi_c\":1.0,\n\"trnamet_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"META1_4578\"\n},\n{\n\"id\":\"TRPS2\",\n\"name\":\"tryptophan synthase B\",\n\"metabolites\":{\n\"h2o_c\":1.0,\n\"indole_c\":-1.0,\n\"ser_L_c\":-1.0,\n\"trp_L_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_17140\"\n},\n{\n\"id\":\"AMAOTr\",\n\"name\":\"7 8 diaminopelargonic acid 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reductase\",\n\"metabolites\":{\n\"h2mpt_c\":-1.0,\n\"h4mpt_c\":1.0,\n\"h_c\":-1.0,\n\"nadp_c\":1.0,\n\"nadph_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"META1_4312\"\n},\n{\n\"id\":\"PRATPP\",\n\"name\":\"phosphoribosyl ATP pyrophosphatase\",\n\"metabolites\":{\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"ppi_c\":1.0,\n\"prbamp_c\":1.0,\n\"prbatp_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_07635\"\n},\n{\n\"id\":\"OMMBZH2\",\n\"name\":\"2 octaprenyl 3 methyl 6 methoxy 1 4 benzoquinone hydroxylase\",\n\"metabolites\":{\n\"2ommbl_c\":-1.0,\n\"dmuqh2_c\":1.0,\n\"h2o_c\":1.0,\n\"h_c\":-2.0,\n\"o2_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"ADMDCr\",\n\"name\":\"S adenosylmethionine decarboxylase\",\n\"metabolites\":{\n\"amet_c\":-1.0,\n\"ametam_c\":1.0,\n\"co2_c\":1.0,\n\"h_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"PGPP180\",\n\"name\":\"phosphatidylglycerophosphatase  n 18 0 \",\n\"metabolites\":{\n\"h2o_c\":-1.0,\n\"pg180_c\":1.0,\n\"pgp180_c\":-1.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"EX_DM_5dr1p\",\n\"name\":\"exchange flux    5  deoxyribose 1 phosphate\",\n\"metabolites\":{\n\"5dr1p_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"3HAD140\",\n\"name\":\"3 hydroxyacyl  acyl carrier protein  dehydratase  n 14 0 \",\n\"metabolites\":{\n\"3hmrsACP_c\":-1.0,\n\"h2o_c\":1.0,\n\"tmrs2eACP_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_00475\"\n},\n{\n\"id\":\"PGPP181\",\n\"name\":\"phosphatidylglycerophosphatase  n 18 1 \",\n\"metabolites\":{\n\"h2o_c\":-1.0,\n\"pg181_c\":1.0,\n\"pgp181_c\":-1.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"TMPKr\",\n\"name\":\"thiamine monophosphate kinase\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"thmmp_c\":-1.0,\n\"thmpp_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_19500\"\n},\n{\n\"id\":\"3HAD141\",\n\"name\":\"3 hydroxyacyl  acyl carrier protein  dehydratase  n 14 1 \",\n\"metabolites\":{\n\"3hcmrs7eACP_c\":-1.0,\n\"h2o_c\":1.0,\n\"t3c7mrseACP_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_00475\"\n},\n{\n\"id\":\"EX_h2o2_e\",\n\"name\":\"exchange flux   H2O2\",\n\"metabolites\":{\n\"h2o2_e\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":0.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"EX_asp_L_e\",\n\"name\":\"exchange flux   L aspartate\",\n\"metabolites\":{\n\"asp_L_e\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":0.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"EX_DM_trnaleu\",\n\"name\":\"exchange flux   tRNA Leu \",\n\"metabolites\":{\n\"trnaleu_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"DUTPDP\",\n\"name\":\"deoxyuridine 5  triphosphate nucleotidohydrolase\",\n\"metabolites\":{\n\"dump_c\":1.0,\n\"dutp_c\":-1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"ppi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_21240\"\n},\n{\n\"id\":\"3PSMES\",\n\"name\":\"5 enolpyruvylshikimate 3 phosphate synthetase\",\n\"metabolites\":{\n\"3psme_c\":1.0,\n\"pep_c\":-1.0,\n\"pi_c\":1.0,\n\"skm3p_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_09925\"\n},\n{\n\"id\":\"FMETTRS\",\n\"name\":\"10 formyltetrahydrofolate L methionyl tRNA fMet  N formyltransferase\",\n\"metabolites\":{\n\"10fthf_c\":-1.0,\n\"fmettrna_c\":1.0,\n\"h_c\":1.0,\n\"mettrna_c\":-1.0,\n\"thf_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_19135\"\n},\n{\n\"id\":\"NAtex\",\n\"name\":\"sodium transport via diffusion  extracellular to periplasm \",\n\"metabolites\":{\n\"na1_e\":-1.0,\n\"na1_p\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"MI3PP\",\n\"name\":\"inositol monophosphatase\",\n\"metabolites\":{\n\"h2o_c\":-1.0,\n\"inost_c\":1.0,\n\"mi3p_D_c\":-1.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_01155\"\n},\n{\n\"id\":\"2AGPEAT160acp\",\n\"name\":\"2 acylglycerophosphoethanolamine acyltransferase  n 16 0 \",\n\"metabolites\":{\n\"2agpe160_c\":-1.0,\n\"ACP_c\":1.0,\n\"palmACP_c\":-1.0,\n\"pe160_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_12415\"\n},\n{\n\"id\":\"OCOAT1r\",\n\"name\":\"succinyl CoA 3 oxo acid CoA transferase\",\n\"metabolites\":{\n\"aacoa_c\":1.0,\n\"acac_c\":-1.0,\n\"succ_c\":1.0,\n\"succoa_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_18630\"\n},\n{\n\"id\":\"ADCMS2\",\n\"name\":\"2 amino 2 deoxyisochorismate synthase\",\n\"metabolites\":{\n\"2ichor_c\":1.0,\n\"chor_c\":-1.0,\n\"gln_L_c\":-1.0,\n\"glu_L_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"PSD181\",\n\"name\":\"phosphatidylserine decarboxylase  n 18 1 \",\n\"metabolites\":{\n\"co2_c\":1.0,\n\"h_c\":-1.0,\n\"pe181_c\":1.0,\n\"ps181_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_03325\"\n},\n{\n\"id\":\"PSD180\",\n\"name\":\"phosphatidylserine decarboxylase  n 18 0 \",\n\"metabolites\":{\n\"co2_c\":1.0,\n\"h_c\":-1.0,\n\"pe180_c\":1.0,\n\"ps180_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_03325\"\n},\n{\n\"id\":\"3OAR60\",\n\"name\":\"3 oxoacyl  acyl carrier protein  reductase  n 6 0 \",\n\"metabolites\":{\n\"3hhexACP_c\":1.0,\n\"3ohexACP_c\":-1.0,\n\"h_c\":-1.0,\n\"nadp_c\":1.0,\n\"nadph_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_16140 or CQW49_17680\"\n},\n{\n\"id\":\"ADOCBIK\",\n\"name\":\"cobinamide kinase\",\n\"metabolites\":{\n\"adocbi_c\":-1.0,\n\"adocbip_c\":1.0,\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"h_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_02455\"\n},\n{\n\"id\":\"PERD\",\n\"name\":\"erythronate 4 phosphate dehydrogenase\",\n\"metabolites\":{\n\"4per_c\":-1.0,\n\"h_c\":1.0,\n\"nad_c\":-1.0,\n\"nadh_c\":1.0,\n\"ohpb_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"H2MB4P\",\n\"name\":\"1 hydroxy 2 methyl 2  E  butenyl 4 diphosphate synthase\",\n\"metabolites\":{\n\"2mecdp_c\":-1.0,\n\"fdxox_c\":2.0,\n\"fdxrd_c\":-2.0,\n\"h2mb4p_c\":1.0,\n\"h2o_c\":1.0,\n\"h_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_12305\"\n},\n{\n\"id\":\"UDPACGAM\",\n\"name\":\"UDP N acetylglucosamine  N acetylmuramyl  pentapeptide  pyrophosphoryl undecaprenol N acetylglucosamine transferase 1\",\n\"metabolites\":{\n\"acetmurpentpeptdpdcp_c\":-1.0,\n\"acgluacetmurpentpeptdpdcp_c\":1.0,\n\"uacgam_c\":-1.0,\n\"udp_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"HACOADH121\",\n\"name\":\"3 hydroxyacyl CoA dehydrogenase  n 12 1 \",\n\"metabolites\":{\n\"3hcdd5ecoa_c\":-1.0,\n\"3ocdd5ecoa_c\":1.0,\n\"h_c\":1.0,\n\"nad_c\":-1.0,\n\"nadh_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_15495 and CQW49_15500\"\n},\n{\n\"id\":\"E4PD\",\n\"name\":\"erythrose 4 phosphate dehydrogenase\",\n\"metabolites\":{\n\"4per_c\":1.0,\n\"e4p_c\":-1.0,\n\"h2o_c\":-1.0,\n\"h_c\":2.0,\n\"nad_c\":-1.0,\n\"nadh_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"CLtex\",\n\"name\":\"chloride transport via diffusion  extracellular to periplasm \",\n\"metabolites\":{\n\"cl_e\":-1.0,\n\"cl_p\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"KDOCT\",\n\"name\":\"3 deoxy D manno octulosonate cytidylyltransferase\",\n\"metabolites\":{\n\"cmpkdo_c\":1.0,\n\"ctp_c\":-1.0,\n\"kdo_c\":-1.0,\n\"ppi_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_04775\"\n},\n{\n\"id\":\"3OAR160\",\n\"name\":\"3 oxoacyl  acyl carrier protein  reductase  n 16 0 \",\n\"metabolites\":{\n\"3hpalmACP_c\":1.0,\n\"3opalmACP_c\":-1.0,\n\"h_c\":-1.0,\n\"nadp_c\":1.0,\n\"nadph_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_16140 or CQW49_17680\"\n},\n{\n\"id\":\"ADSL1r\",\n\"name\":\"adenylosuccinate lyase\",\n\"metabolites\":{\n\"amp_c\":1.0,\n\"dcamp_c\":-1.0,\n\"fum_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_16800\"\n},\n{\n\"id\":\"3OAR161\",\n\"name\":\"3 oxoacyl  acyl carrier protein  reductase  n 16 1 \",\n\"metabolites\":{\n\"3hcpalm9eACP_c\":1.0,\n\"3ocpalm9eACP_c\":-1.0,\n\"h_c\":-1.0,\n\"nadp_c\":1.0,\n\"nadph_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_16140 or CQW49_17680\"\n},\n{\n\"id\":\"PHYNS2\",\n\"name\":\"phytoene synthase 2\",\n\"metabolites\":{\n\"phyn_c\":1.0,\n\"ppi_c\":1.0,\n\"prephyn_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_11740 or CQW49_03025\"\n},\n{\n\"id\":\"PGI\",\n\"name\":\"phosphoglucose isomerase\",\n\"metabolites\":{\n\"f6p_c\":-1.0,\n\"g6p_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_09940\"\n},\n{\n\"id\":\"HFACOAE60\",\n\"name\":\"acyl CoA thioesterase II  n h6 0 \",\n\"metabolites\":{\n\"R_3hhc_c\":1.0,\n\"R_3hhcoa_c\":-1.0,\n\"coa_c\":1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_00725 or CQW49_04870 or CQW49_01990\"\n},\n{\n\"id\":\"PGK\",\n\"name\":\"phosphoglycerate kinase\",\n\"metabolites\":{\n\"13dpg_c\":1.0,\n\"3pg_c\":-1.0,\n\"adp_c\":1.0,\n\"atp_c\":-1.0\n},\n\"lower_bound\":-1000,\n\"upper_bound\":1000,\n\"gene_reaction_rule\":\"CQW49_11875\"\n},\n{\n\"id\":\"GF6PTAr\",\n\"name\":\"L glutamine D fructose 6 phosphate aminotransferase\",\n\"metabolites\":{\n\"f6p_c\":-1.0,\n\"gam6p_c\":1.0,\n\"gln_L_c\":-1.0,\n\"glu_L_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_17215 or CQW49_06600\"\n},\n{\n\"id\":\"UAMAGS\",\n\"name\":\"UDP N acetylmuramoylalanine  D glutamate ligase\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"glu_D_c\":-1.0,\n\"h_c\":1.0,\n\"pi_c\":1.0,\n\"uama_c\":-1.0,\n\"uamag_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_11220\"\n},\n{\n\"id\":\"PGM\",\n\"name\":\"phosphoglyceromutase\",\n\"metabolites\":{\n\"2pg_c\":-1.0,\n\"3pg_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_16905\"\n},\n{\n\"id\":\"MMPTC\",\n\"name\":\"methenyltetrahydrometanopterin cyclohydrolase\",\n\"metabolites\":{\n\"5fh4mpt_c\":1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"meh4mpt_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_13495\"\n},\n{\n\"id\":\"MG2tex\",\n\"name\":\"magnesium transport via diffusion  extracellular to periplasm \",\n\"metabolites\":{\n\"mg2_e\":-1.0,\n\"mg2_p\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"MPTAT\",\n\"name\":\"molybdopterin adenylyltransferase\",\n\"metabolites\":{\n\"atp_c\":-1.0,\n\"h_c\":-1.0,\n\"mpt_c\":-1.0,\n\"mptamp_c\":1.0,\n\"ppi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"FUMtex\",\n\"name\":\"fumarate transport via diffusion  extracellular to periplasm \",\n\"metabolites\":{\n\"fum_e\":-1.0,\n\"fum_p\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"EX_cl_e\",\n\"name\":\"exchange flux   chloride\",\n\"metabolites\":{\n\"cl_e\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"LPLIP1AGPC160\",\n\"name\":\"lysophospholipase C1  n 16 0 \",\n\"metabolites\":{\n\"1agpc160_c\":-1.0,\n\"g3pc_c\":1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"hdca_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_20340\"\n},\n{\n\"id\":\"PPBNGS\",\n\"name\":\"porphobilinogen synthase\",\n\"metabolites\":{\n\"5aop_c\":-2.0,\n\"h2o_c\":2.0,\n\"h_c\":1.0,\n\"ppbng_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_01135\"\n},\n{\n\"id\":\"PAPR\",\n\"name\":\"phosphoadenosine phosphosulfate reductase\",\n\"metabolites\":{\n\"pap_c\":1.0,\n\"paps_c\":-1.0,\n\"so3_c\":1.0,\n\"trdox_c\":1.0,\n\"trdrd_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_00345\"\n},\n{\n\"id\":\"PYRt2rpp\",\n\"name\":\"pyruvate symport  periplasm to cytoplasm \",\n\"metabolites\":{\n\"h_c\":1.0,\n\"h_p\":-1.0,\n\"pyr_c\":1.0,\n\"pyr_p\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"PSP_D\",\n\"name\":\"phosphoserine phosphatase  D \",\n\"metabolites\":{\n\"h2o_c\":-1.0,\n\"pi_c\":1.0,\n\"pser_D_c\":-1.0,\n\"ser_D_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_18580\"\n},\n{\n\"id\":\"MALCOATE\",\n\"name\":\"malyl CoA thioesterase\",\n\"metabolites\":{\n\"coa_c\":1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"malScoa_c\":-1.0,\n\"mal_L_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_12840\"\n},\n{\n\"id\":\"OCMPH2\",\n\"name\":\"2 octaprenyl 6 methoxyphenol hydroxylase\",\n\"metabolites\":{\n\"2ombzl_c\":1.0,\n\"2omph_c\":-1.0,\n\"h2o_c\":1.0,\n\"h_c\":-2.0,\n\"o2_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_20445\"\n},\n{\n\"id\":\"PIt2rpp\",\n\"name\":\"PiT phosphate transporter\",\n\"metabolites\":{\n\"h_c\":1.0,\n\"h_p\":-1.0,\n\"pi_c\":1.0,\n\"pi_p\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_10890\"\n},\n{\n\"id\":\"PSP_L\",\n\"name\":\"phosphoserine phosphatase\",\n\"metabolites\":{\n\"h2o_c\":-1.0,\n\"pi_c\":1.0,\n\"pser_L_c\":-1.0,\n\"ser_L_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_18580\"\n},\n{\n\"id\":\"SPMS\",\n\"name\":\"spermidine synthase\",\n\"metabolites\":{\n\"5mta_c\":1.0,\n\"ametam_c\":-1.0,\n\"h_c\":1.0,\n\"ptrc_c\":-1.0,\n\"spmd_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_11805\"\n},\n{\n\"id\":\"FACOAE180\",\n\"name\":\"acyl CoA thioesterase II  n 18 0 \",\n\"metabolites\":{\n\"coa_c\":1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"ocdca_c\":1.0,\n\"stcoa_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_00725 or CQW49_04870 or CQW49_01990\"\n},\n{\n\"id\":\"EX_pi_e\",\n\"name\":\"exchange flux   phosphate\",\n\"metabolites\":{\n\"pi_e\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"UGMDDS\",\n\"name\":\"UDP N acetylmuramoylalanyl D glutamyl 2 6 diaminopimelate D alanyl D alanine ligase\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"alaala_c\":-1.0,\n\"atp_c\":-1.0,\n\"h_c\":1.0,\n\"pi_c\":1.0,\n\"ugmd_c\":-1.0,\n\"ugmda_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_11210\"\n},\n{\n\"id\":\"OCBT\",\n\"name\":\"ornithine carbamoyltransferase\",\n\"metabolites\":{\n\"cbp_c\":-1.0,\n\"citr_L_c\":1.0,\n\"h_c\":1.0,\n\"orn_c\":-1.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_13055\"\n},\n{\n\"id\":\"MNtex\",\n\"name\":\"manganese transport via diffusion  extracellular to periplasm \",\n\"metabolites\":{\n\"mn2_e\":-1.0,\n\"mn2_p\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"HEMEOS\",\n\"name\":\"heme O synthase\",\n\"metabolites\":{\n\"frdp_c\":-1.0,\n\"h2o_c\":-1.0,\n\"hemeO_c\":1.0,\n\"pheme_c\":-1.0,\n\"ppi_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_10035\"\n},\n{\n\"id\":\"BDH\",\n\"name\":\"D beta hydroxybutyrate dehydrogenase\",\n\"metabolites\":{\n\"acac_c\":1.0,\n\"bhb_c\":-1.0,\n\"h_c\":1.0,\n\"nad_c\":-1.0,\n\"nadh_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_03370\"\n},\n{\n\"id\":\"G5SD\",\n\"name\":\"glutamate 5 semialdehyde dehydrogenase\",\n\"metabolites\":{\n\"glu5p_c\":-1.0,\n\"glu5sa_c\":1.0,\n\"h_c\":-1.0,\n\"nadp_c\":1.0,\n\"nadph_c\":-1.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"(CQW49_02220 and CQW49_15675) or CQW49_15675\"\n},\n{\n\"id\":\"AGPR\",\n\"name\":\"N acetylglutamylphosphate reductase\",\n\"metabolites\":{\n\"acg5p_c\":-1.0,\n\"acg5sa_c\":1.0,\n\"h_c\":-1.0,\n\"nadp_c\":1.0,\n\"nadph_c\":-1.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_20035\"\n},\n{\n\"id\":\"3OAR140\",\n\"name\":\"3 oxoacyl  acyl carrier protein  reductase  n 14 0 \",\n\"metabolites\":{\n\"3hmrsACP_c\":1.0,\n\"3omrsACP_c\":-1.0,\n\"h_c\":-1.0,\n\"nadp_c\":1.0,\n\"nadph_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_16140 or CQW49_17680\"\n},\n{\n\"id\":\"3OAR141\",\n\"name\":\"3 oxoacyl  acyl carrier protein  reductase  n 14 1 \",\n\"metabolites\":{\n\"3hcmrs7eACP_c\":1.0,\n\"3ocmrs7eACP_c\":-1.0,\n\"h_c\":-1.0,\n\"nadp_c\":1.0,\n\"nadph_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_16140 or CQW49_17680\"\n},\n{\n\"id\":\"EX_ribona_e\",\n\"name\":\"exchange flux   D ribonate\",\n\"metabolites\":{\n\"ribona_e\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":0.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"OHPHM\",\n\"name\":\"2 octaprenyl 6 hydroxyphenol methylase\",\n\"metabolites\":{\n\"2ohph_c\":-1.0,\n\"2omph_c\":1.0,\n\"ahcys_c\":1.0,\n\"amet_c\":-1.0,\n\"h_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_02235\"\n},\n{\n\"id\":\"GALCDARABtex\",\n\"name\":\"3 O b D galactopyranosyl D arabinose transport via diffusion  extracellular to periplasm \",\n\"metabolites\":{\n\"galcDarab_e\":-1.0,\n\"galcDarab_p\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"O2tex\",\n\"name\":\"O2 transport via diffusion  extracellular to periplasm \",\n\"metabolites\":{\n\"o2_e\":-1.0,\n\"o2_p\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"ARABAtex\",\n\"name\":\"L arabinonate transport via diffusion  extracellular to periplasm \",\n\"metabolites\":{\n\"araba_e\":-1.0,\n\"araba_p\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"MAN1PT\",\n\"name\":\"mannose 1 phosphate guanylyltransferase\",\n\"metabolites\":{\n\"gdpmann_c\":1.0,\n\"gtp_c\":-1.0,\n\"h_c\":-1.0,\n\"man1p_c\":-1.0,\n\"ppi_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_21100\"\n},\n{\n\"id\":\"ADSL2r\",\n\"name\":\"5  phosphoribosyl 4  N succinocarboxamide  5 aminoimidazole lyase\",\n\"metabolites\":{\n\"25aics_c\":-1.0,\n\"aicar_c\":1.0,\n\"fum_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_16800\"\n},\n{\n\"id\":\"TALA\",\n\"name\":\"transaldolase\",\n\"metabolites\":{\n\"e4p_c\":1.0,\n\"f6p_c\":1.0,\n\"g3p_c\":-1.0,\n\"s7p_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"META1_1862 or META1_4950\"\n},\n{\n\"id\":\"AGPAT161\",\n\"name\":\"lysophosphatidic acid acyltransferase  n 16 1 \",\n\"metabolites\":{\n\"1hdec9eg3p_c\":-1.0,\n\"ACP_c\":1.0,\n\"hdeACP_c\":-1.0,\n\"pa161_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_01980 or CQW49_09950\"\n},\n{\n\"id\":\"3HAD60\",\n\"name\":\"3 hydroxyacyl  acyl carrier protein  dehydratase  n 6 0 \",\n\"metabolites\":{\n\"3hhexACP_c\":-1.0,\n\"h2o_c\":1.0,\n\"thex2eACP_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_00475\"\n},\n{\n\"id\":\"PGCDr\",\n\"name\":\"D 3 phosphoglycerate dehydrogenase\",\n\"metabolites\":{\n\"3pg_c\":-1.0,\n\"3php_c\":1.0,\n\"h_c\":1.0,\n\"nad_c\":-1.0,\n\"nadh_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_10845\"\n},\n{\n\"id\":\"AGPAT160\",\n\"name\":\"lysophosphatidic acid acyltransferase  n 16 0 \",\n\"metabolites\":{\n\"1hdecg3p_c\":-1.0,\n\"ACP_c\":1.0,\n\"pa160_c\":1.0,\n\"palmACP_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_01980 or CQW49_09950\"\n},\n{\n\"id\":\"GTHPp\",\n\"name\":\"glutathione peroxidase  periplasmic \",\n\"metabolites\":{\n\"gthox_c\":1.0,\n\"gthrd_c\":-2.0,\n\"h2o2_p\":-1.0,\n\"h2o_p\":2.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_06010 or CQW49_06015\"\n},\n{\n\"id\":\"FACOAE160\",\n\"name\":\"acyl CoA thioesterase II  n 16 0 \",\n\"metabolites\":{\n\"coa_c\":1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"hdca_c\":1.0,\n\"pmtcoa_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_00725 or CQW49_04870 or CQW49_01990\"\n},\n{\n\"id\":\"PDH\",\n\"name\":\"pyruvate dehydrogenase\",\n\"metabolites\":{\n\"accoab_c\":1,\n\"co2_c\":1,\n\"coa_c\":-1,\n\"nad_c\":-1,\n\"nadh_c\":1,\n\"pyr_c\":-1\n},\n\"lower_bound\":0,\n\"upper_bound\":1000,\n\"gene_reaction_rule\":\"CQW49_01940 and CQW49_01945 and CQW49_01950 and CQW49_06860 and CQW49_06730 and CQW49_06735\"\n},\n{\n\"id\":\"3OAR120\",\n\"name\":\"3 oxoacyl  acyl carrier protein  reductase  n 12 0 \",\n\"metabolites\":{\n\"3hddecACP_c\":1.0,\n\"3oddecACP_c\":-1.0,\n\"h_c\":-1.0,\n\"nadp_c\":1.0,\n\"nadph_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_16140 or CQW49_17680\"\n},\n{\n\"id\":\"ILETA\",\n\"name\":\"amino acid transferase  isoleucine \",\n\"metabolites\":{\n\"3mop_c\":-1.0,\n\"akg_c\":1.0,\n\"glu_L_c\":-1.0,\n\"ile_L_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_02780\"\n},\n{\n\"id\":\"3OAR121\",\n\"name\":\"3 oxoacyl  acyl carrier protein  reductase  n 12 1 \",\n\"metabolites\":{\n\"3hcddec5eACP_c\":1.0,\n\"3ocddec5eACP_c\":-1.0,\n\"h_c\":-1.0,\n\"nadp_c\":1.0,\n\"nadph_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_16140 or CQW49_17680\"\n},\n{\n\"id\":\"MTAP\",\n\"name\":\"5  methylthioadenosine phosphorylase\",\n\"metabolites\":{\n\"5mdr1p_c\":1.0,\n\"5mta_c\":-1.0,\n\"ade_c\":1.0,\n\"pi_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_00280\"\n},\n{\n\"id\":\"EX_k_e\",\n\"name\":\"exchange flux   potassium\",\n\"metabolites\":{\n\"k_e\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"H2Otex\",\n\"name\":\"H2O transport via diffusion  extracellular to periplasm \",\n\"metabolites\":{\n\"h2o_e\":-1.0,\n\"h2o_p\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"DAPE\",\n\"name\":\"diaminopimelate epimerase\",\n\"metabolites\":{\n\"26dap_LL_c\":-1.0,\n\"26dap_M_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_00230\"\n},\n{\n\"id\":\"ASPK\",\n\"name\":\"aspartokinase\",\n\"metabolites\":{\n\"4pasp_c\":1.0,\n\"adp_c\":1.0,\n\"asp_L_c\":-1.0,\n\"atp_c\":-1.0\n},\n\"lower_bound\":0,\n\"upper_bound\":1000,\n\"gene_reaction_rule\":\"CQW49_02240\"\n},\n{\n\"id\":\"EX_DM_h2mpt\",\n\"name\":\"exchange flux    7 8 dihydromethanopterin\",\n\"metabolites\":{\n\"h2mpt_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"NO3tex\",\n\"name\":\"nitrate transport via diffusion  extracellular to periplasm \",\n\"metabolites\":{\n\"no3_e\":-1.0,\n\"no3_p\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"EX_xyl_D_e\",\n\"name\":\"exchange flux   D xylose\",\n\"metabolites\":{\n\"xyl_D_e\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":0.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"HMPK1\",\n\"name\":\"hydroxymethylpyrimidine kinase\",\n\"metabolites\":{\n\"4ahmmp_c\":-1.0,\n\"4ampm_c\":1.0,\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"h_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_13110\"\n},\n{\n\"id\":\"Htex\",\n\"name\":\"H  transport via diffusion  extracellular to periplasm \",\n\"metabolites\":{\n\"h_e\":-1.0,\n\"h_p\":1.0\n},\n\"lower_bound\":0,\n\"upper_bound\":1000,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"PDX5PO\",\n\"name\":\"pyridoxine 5  phosphate oxidase\",\n\"metabolites\":{\n\"h2o2_c\":1.0,\n\"o2_c\":-1.0,\n\"pdx5p_c\":-1.0,\n\"pydx5p_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_12905 or CQW49_11530\"\n},\n{\n\"id\":\"UPP3MT2\",\n\"name\":\"uroporphyrin III C methyltransferase 2\",\n\"metabolites\":{\n\"ahcys_c\":1.0,\n\"amet_c\":-1.0,\n\"dscl_c\":1.0,\n\"pre1_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_21195\"\n},\n{\n\"id\":\"FORtex\",\n\"name\":\"formate transport via diffusion  extracellular to periplasm \",\n\"metabolites\":{\n\"for_e\":-1.0,\n\"for_p\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"GTHOr\",\n\"name\":\"glutathione reductase\",\n\"metabolites\":{\n\"gthox_c\":-1.0,\n\"gthrd_c\":2.0,\n\"h_c\":-1.0,\n\"nadp_c\":1.0,\n\"nadph_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_14250\"\n},\n{\n\"id\":\"ACS2\",\n\"name\":\"propionyl CoA synthetase\",\n\"metabolites\":{\n\"amp_c\":1.0,\n\"atp_c\":-1.0,\n\"coa_c\":-1.0,\n\"ppa_c\":-1.0,\n\"ppcoa_c\":1.0,\n\"ppi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_13835\"\n},\n{\n\"id\":\"AGPAT180\",\n\"name\":\"lysophosphatidic acid acyltransferase  n 18 0 \",\n\"metabolites\":{\n\"1odecg3p_c\":-1.0,\n\"ACP_c\":1.0,\n\"ocdcaACP_c\":-1.0,\n\"pa180_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_01980 or CQW49_09950\"\n},\n{\n\"id\":\"G5SADr\",\n\"name\":\"L glutamate gamma semialdehyde  cyclase dehydratase \",\n\"metabolites\":{\n\"1pyr5c_c\":1.0,\n\"glu5sa_c\":-1.0,\n\"h2o_c\":1.0,\n\"h_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"SP0001\"\n},\n{\n\"id\":\"AGPAT181\",\n\"name\":\"lysophosphatidic acid acyltransferase  n 18 1 \",\n\"metabolites\":{\n\"1odec11eg3p_c\":-1.0,\n\"ACP_c\":1.0,\n\"octeACP_c\":-1.0,\n\"pa181_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_01980 or CQW49_09950\"\n},\n{\n\"id\":\"EX_etoh_e\",\n\"name\":\"exchange flux   ethanol\",\n\"metabolites\":{\n\"etoh_e\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":0.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"UAPGR\",\n\"name\":\"UDP N acetylenolpyruvoylglucosamine reductase\",\n\"metabolites\":{\n\"h_c\":-1.0,\n\"nadp_c\":1.0,\n\"nadph_c\":-1.0,\n\"uaccg_c\":-1.0,\n\"uamr_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_11240\"\n},\n{\n\"id\":\"NDPK8\",\n\"name\":\"dADP kinase\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"dadp_c\":-1.0,\n\"datp_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"META1_1990\"\n},\n{\n\"id\":\"NDPK7\",\n\"name\":\"dCDP kinase\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"dcdp_c\":-1.0,\n\"dctp_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"META1_1990\"\n},\n{\n\"id\":\"ATPS4rpp\",\n\"name\":\"ATP synthase\",\n\"metabolites\":{\n\"adp_c\":-1.0,\n\"atp_c\":1.0,\n\"h2o_c\":1.0,\n\"h_c\":3.0,\n\"h_p\":-4.0,\n\"pi_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_19220 and CQW49_00300 and CQW49_19240 and CQW49_19235 and CQW49_00305 and CQW49_19230 and CQW49_19225 and CQW49_00310 and CQW49_00290 and CQW49_00295 and CQW49_00515 and CQW49_00550\"\n},\n{\n\"id\":\"3HAD80\",\n\"name\":\"3 hydroxyacyl  acyl carrier protein  dehydratase  n 8 0 \",\n\"metabolites\":{\n\"3hoctACP_c\":-1.0,\n\"h2o_c\":1.0,\n\"toct2eACP_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_00475\"\n},\n{\n\"id\":\"NDPK5\",\n\"name\":\"dGDP kinase\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"dgdp_c\":-1.0,\n\"dgtp_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"META1_1990\"\n},\n{\n\"id\":\"NDPK4\",\n\"name\":\"dTDP kinase\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"dtdp_c\":-1.0,\n\"dttp_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"META1_1990\"\n},\n{\n\"id\":\"NDPK3\",\n\"name\":\"CDP kinase\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"cdp_c\":-1.0,\n\"ctp_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"META1_1990\"\n},\n{\n\"id\":\"FACOAE140\",\n\"name\":\"acyl CoA thioesterase II  n 14 0 \",\n\"metabolites\":{\n\"coa_c\":1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"tdcoa_c\":-1.0,\n\"ttdca_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_00725 or CQW49_04870 or CQW49_01990\"\n},\n{\n\"id\":\"NDPK2\",\n\"name\":\"UDP kinase\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"udp_c\":-1.0,\n\"utp_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"META1_1990\"\n},\n{\n\"id\":\"NDPK1\",\n\"name\":\"GDP kinase\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"gdp_c\":-1.0,\n\"gtp_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"META1_1990\"\n},\n{\n\"id\":\"CA2NAtpp\",\n\"name\":\"sodium calcium exchanger\",\n\"metabolites\":{\n\"ca2_c\":-1.0,\n\"ca2_e\":1.0,\n\"na1_c\":1.0,\n\"na1_p\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"META1_2668\"\n},\n{\n\"id\":\"METACH\",\n\"name\":\"O acetylhomoserine sulfhydrylase\",\n\"metabolites\":{\n\"ac_c\":1.0,\n\"achms_c\":-1.0,\n\"h2s_c\":-1.0,\n\"h_c\":1.0,\n\"hcys_L_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"META1_2508 and META1_5055 and CQW49_03805 and META1_3362\"\n},\n{\n\"id\":\"GGTT\",\n\"name\":\"R geranylgeranyltranstransferase\",\n\"metabolites\":{\n\"ggdp_c\":-1.0,\n\"ipdp_c\":-1.0,\n\"pendp_c\":1.0,\n\"ppi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_18820\"\n},\n{\n\"id\":\"ANPRT\",\n\"name\":\"anthranilate phosphoribosyltransferase\",\n\"metabolites\":{\n\"anth_c\":-1.0,\n\"ppi_c\":1.0,\n\"pran_c\":1.0,\n\"prpp_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_20180\"\n},\n{\n\"id\":\"AKGt2rpp\",\n\"name\":\"a ketoglutarate MFS transporter\",\n\"metabolites\":{\n\"akg_c\":1.0,\n\"akg_p\":-1.0,\n\"h_c\":1.0,\n\"h_p\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_11045\"\n},\n{\n\"id\":\"EX_12ppd_S_e\",\n\"name\":\"exchange flux   1 2 propanediol\",\n\"metabolites\":{\n\"12ppd_S_e\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":0.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"HFACOAE80\",\n\"name\":\"acyl CoA thioesterase II  n h8 0 \",\n\"metabolites\":{\n\"R_3hocoa_c\":-1.0,\n\"R_3hoct_c\":1.0,\n\"coa_c\":1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_00725 or CQW49_04870 or CQW49_01990\"\n},\n{\n\"id\":\"3OAR100\",\n\"name\":\"3 oxoacyl  acyl carrier protein  reductase  n 10 0 \",\n\"metabolites\":{\n\"3hdecACP_c\":1.0,\n\"3odecACP_c\":-1.0,\n\"h_c\":-1.0,\n\"nadp_c\":1.0,\n\"nadph_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_16140 or CQW49_17680\"\n},\n{\n\"id\":\"MECDPS\",\n\"name\":\"2C methyl D erythritol 2 4 cyclodiphosphate synthase\",\n\"metabolites\":{\n\"2mecdp_c\":1.0,\n\"2p4c2me_c\":-1.0,\n\"cmp_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_01675\"\n},\n{\n\"id\":\"GLNS\",\n\"name\":\"glutamine synthetase\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"gln_L_c\":1.0,\n\"glu_L_c\":-1.0,\n\"h_c\":1.0,\n\"nh4_c\":-1.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_20675 or CQW49_20665\"\n},\n{\n\"id\":\"F6PPKL\",\n\"name\":\"D fructose 6 phosphate phosphoketolase\",\n\"metabolites\":{\n\"actp_c\":1.0,\n\"e4p_c\":1.0,\n\"f6p_c\":-1.0,\n\"h2o_c\":1.0,\n\"pi_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"META1_3806 or META1_0387\"\n},\n{\n\"id\":\"Zn2tex\",\n\"name\":\"zinc transport via diffusion  extracellular to periplasm \",\n\"metabolites\":{\n\"zn2_e\":-1.0,\n\"zn2_p\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"MG2uabcpp\",\n\"name\":\"magnesium ABC transporter\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"mg2_c\":1.0,\n\"mg2_p\":-1.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_12745 or CQW49_17395\"\n},\n{\n\"id\":\"ACOATA\",\n\"name\":\"acetyl CoA ACP transacylase\",\n\"metabolites\":{\n\"ACP_c\":-1.0,\n\"acACP_c\":1.0,\n\"accoa_c\":-1.0,\n\"coa_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_03730\"\n},\n{\n\"id\":\"EX_fald_e\",\n\"name\":\"exchange flux   formaldehyde\",\n\"metabolites\":{\n\"fald_e\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":0.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"EX_nh4_e\",\n\"name\":\"exchange flux   nitrogen\",\n\"metabolites\":{\n\"nh4_e\":-1.0\n},\n\"lower_bound\":0,\n\"upper_bound\":0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"MOHMT\",\n\"name\":\"3 methyl 2 oxobutanoate hydroxymethyltransferase\",\n\"metabolites\":{\n\"2dhp_c\":1.0,\n\"3mob_c\":-1.0,\n\"h2o_c\":-1.0,\n\"mlthf_c\":-1.0,\n\"thf_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_13525\"\n},\n{\n\"id\":\"CMBLD2\",\n\"name\":\"dienelactone hydrolase  trans \",\n\"metabolites\":{\n\"2mac_c\":1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"tcmbo_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_13755\"\n},\n{\n\"id\":\"5DGLCNtex\",\n\"name\":\"5 dehydro D gluconate transport via diffusion  extracellular to periplasm \",\n\"metabolites\":{\n\"5dglcn_e\":-1.0,\n\"5dglcn_p\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"AGDC_r\",\n\"name\":\"N acetylglucosamine 6 phosphate deacetylase\",\n\"metabolites\":{\n\"ac_c\":1.0,\n\"acgam6p_c\":-1.0,\n\"gam6p_c\":1.0,\n\"h2o_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_17210\"\n},\n{\n\"id\":\"HCO3E\",\n\"name\":\"carbonic anhydrase\",\n\"metabolites\":{\n\"co2_c\":-1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"hco3_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_10875 or CQW49_20715 or CQW49_12845 or CQW49_20215\"\n},\n{\n\"id\":\"CMBLD4\",\n\"name\":\"dienelactone hydrolase  cis \",\n\"metabolites\":{\n\"2mac_c\":1.0,\n\"c4cmbo_c\":-1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_13755\"\n},\n{\n\"id\":\"CMBLD3\",\n\"name\":\"carboxymethylenebutenolidase\",\n\"metabolites\":{\n\"2chmac_c\":1.0,\n\"c2ch4cmo_c\":-1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_13755\"\n},\n{\n\"id\":\"OXAFORtpp\",\n\"name\":\"oxalate formate antiporter  periplasm to cytoplasm \",\n\"metabolites\":{\n\"for_c\":-1.0,\n\"for_p\":1.0,\n\"oxa_c\":1.0,\n\"oxa_p\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_16745\"\n},\n{\n\"id\":\"EX_na1_e\",\n\"name\":\"exchange flux   Na \",\n\"metabolites\":{\n\"na1_e\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"EX_oxa_e\",\n\"name\":\"exchange flux   oxalate\",\n\"metabolites\":{\n\"oxa_e\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":0.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"PHYNDH2\",\n\"name\":\"phytoene dehydrogenase 2\",\n\"metabolites\":{\n\"h2o_c\":2.0,\n\"o2_c\":-1.0,\n\"oxEA_c\":1.0,\n\"phyflun_c\":-1.0,\n\"rdEA_c\":-1.0,\n\"zcar_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"META1_3219 or META1_3670\"\n},\n{\n\"id\":\"QULNS\",\n\"name\":\"quinolinate synthetase\",\n\"metabolites\":{\n\"dhap_c\":-1.0,\n\"h2o_c\":2.0,\n\"iasp_c\":-1.0,\n\"pi_c\":1.0,\n\"quln_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_10320\"\n},\n{\n\"id\":\"GLUCYS\",\n\"name\":\"gamma glutamylcysteine synthetase\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"cys_L_c\":-1.0,\n\"glu_L_c\":-1.0,\n\"glucys_c\":1.0,\n\"h_c\":1.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":0,\n\"upper_bound\":1000,\n\"gene_reaction_rule\":\"CQW49_17545\"\n},\n{\n\"id\":\"EX_glc_e\",\n\"name\":\"exchange flux   D glucose\",\n\"metabolites\":{\n\"glc_D_e\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":0.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"IGPDH\",\n\"name\":\"imidazoleglycerol phosphate dehydratase\",\n\"metabolites\":{\n\"eig3p_c\":-1.0,\n\"h2o_c\":1.0,\n\"imacp_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_07600\"\n},\n{\n\"id\":\"ICDHyr\",\n\"name\":\"isocitrate dehydrogenase\",\n\"metabolites\":{\n\"akg_c\":1.0,\n\"co2_c\":1.0,\n\"icit_c\":-1.0,\n\"nadp_c\":-1.0,\n\"nadph_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_01450\"\n},\n{\n\"id\":\"MACACI\",\n\"name\":\"maleylacetoacetate isomerase\",\n\"metabolites\":{\n\"4fumacac_c\":1.0,\n\"4mlacac_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_05650\"\n},\n{\n\"id\":\"FORMMFRHD\",\n\"name\":\"formyl MFS hydrolysis\",\n\"metabolites\":{\n\"for_c\":1.0,\n\"formmfr_b__c\":-1.0,\n\"h2o_c\":-1.0,\n\"mfr_b__c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_03825 and CQW49_03830 and CQW49_03840\"\n},\n{\n\"id\":\"R3HAD40\",\n\"name\":\"3 hydroxyacyl  acyl carrier protein  dehydratase  n 4 0 \",\n\"metabolites\":{\n\"R_3hbacp_c\":-1.0,\n\"but2eACP_c\":1.0,\n\"h2o_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_00475\"\n},\n{\n\"id\":\"ENCOAI141\",\n\"name\":\"enoyl CoA isomerase  n 14 0 \",\n\"metabolites\":{\n\"ctd3ecoa_c\":1.0,\n\"td2coa_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_15495 and CQW49_15500\"\n},\n{\n\"id\":\"ENCOAI142\",\n\"name\":\"enoyl CoA isomerase  n 14 1 \",\n\"metabolites\":{\n\"3ctd7ecoa_c\":1.0,\n\"t2ctd7ecoa_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_15495 and CQW49_15500\"\n},\n{\n\"id\":\"ACGLCAM\",\n\"name\":\"beta N acetyl glucosaminidase\",\n\"metabolites\":{\n\"GlcNacanhMurNac_c\":-1.0,\n\"acgam_c\":1.0,\n\"anhMurNAc_c\":1.0,\n\"h2o_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_06200\"\n},\n{\n\"id\":\"ARGSSr\",\n\"name\":\"argininosuccinate synthase\",\n\"metabolites\":{\n\"amp_c\":1.0,\n\"argsuc_c\":1.0,\n\"asp_L_c\":-1.0,\n\"atp_c\":-1.0,\n\"citr_L_c\":-1.0,\n\"h_c\":1.0,\n\"ppi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_15625\"\n},\n{\n\"id\":\"FACOAE60\",\n\"name\":\"acyl CoA thioesterase II  n 6 0 \",\n\"metabolites\":{\n\"coa_c\":1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"hxa_c\":1.0,\n\"hxcoa_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_00725 or CQW49_04870 or CQW49_01990\"\n},\n{\n\"id\":\"ACOAD161\",\n\"name\":\"acyl CoA dehydrogenase  n 16 1 \",\n\"metabolites\":{\n\"fad_c\":-1.0,\n\"fadh2_c\":1.0,\n\"hdcoa_c\":-1.0,\n\"t3chd9ecoa_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_15490 or CQW49_03065 or CQW49_11850\"\n},\n{\n\"id\":\"UMPK\",\n\"name\":\"uridylate kinase\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"udp_c\":1.0,\n\"ump_c\":-1.0\n},\n\"lower_bound\":0,\n\"upper_bound\":1000,\n\"gene_reaction_rule\":\"CQW49_03815\"\n},\n{\n\"id\":\"PRASCS\",\n\"name\":\"phosphoribosylaminoimidazole succinocarboxamide 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isomerase\",\n\"metabolites\":{\n\"dhap_c\":1.0,\n\"g3p_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_01355\"\n},\n{\n\"id\":\"PSSA181\",\n\"name\":\"phosphatidylserine synthase  n 18 1 \",\n\"metabolites\":{\n\"cdpdodec11eg_c\":-1.0,\n\"cmp_c\":1.0,\n\"h_c\":1.0,\n\"ps181_c\":1.0,\n\"ser_L_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_03330\"\n},\n{\n\"id\":\"PSSA180\",\n\"name\":\"phosphatidylserine synthase  n 18 0 \",\n\"metabolites\":{\n\"cdpdodecg_c\":-1.0,\n\"cmp_c\":1.0,\n\"h_c\":1.0,\n\"ps180_c\":1.0,\n\"ser_L_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_03330\"\n},\n{\n\"id\":\"NH4tpp\",\n\"name\":\"NH3 transport  periplasm to cytoplasm \",\n\"metabolites\":{\n\"h_c\":1.0,\n\"h_p\":-1.0,\n\"nh4_c\":1.0,\n\"nh4_p\":-1.0\n},\n\"lower_bound\":0,\n\"upper_bound\":1000,\n\"gene_reaction_rule\":\"CQW49_04880\"\n},\n{\n\"id\":\"TRE6PP\",\n\"name\":\"trehalose 6 phosphate phosphatase\",\n\"metabolites\":{\n\"h2o_c\":-1.0,\n\"pi_c\":1.0,\n\"tre6p_c\":-1.0,\n\"tre_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_03340 or CQW49_12970\"\n},\n{\n\"id\":\"TRE6PS\",\n\"name\":\"trehalose 6 phosphate synthase\",\n\"metabolites\":{\n\"g6p_c\":-1.0,\n\"h_c\":1.0,\n\"tre6p_c\":1.0,\n\"udp_c\":1.0,\n\"udpg_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_12980\"\n},\n{\n\"id\":\"THRPD\",\n\"name\":\"L threonine O 3 phosphate decarboxylase\",\n\"metabolites\":{\n\"applp_c\":1.0,\n\"co2_c\":1.0,\n\"h_c\":-1.0,\n\"thrp_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_02450\"\n},\n{\n\"id\":\"ACBIPGT\",\n\"name\":\"cobinamide phosphate guanylyltransferase\",\n\"metabolites\":{\n\"adocbip_c\":-1.0,\n\"agdpcbi_c\":1.0,\n\"gtp_c\":-1.0,\n\"h_c\":-1.0,\n\"ppi_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_02455\"\n},\n{\n\"id\":\"MAN6PI\",\n\"name\":\"mannose 6 phosphate isomerase\",\n\"metabolites\":{\n\"f6p_c\":-1.0,\n\"man6p_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_21100\"\n},\n{\n\"id\":\"THRPS\",\n\"name\":\"L threonine kinase\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"h_c\":1.0,\n\"thr_L_c\":-1.0,\n\"thrp_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"MESACOAH\",\n\"name\":\"mesaconyl CoA hydratase\",\n\"metabolites\":{\n\"bmmalcoa_c\":1.0,\n\"h2o_c\":-1.0,\n\"mesaccoa_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_03910\"\n},\n{\n\"id\":\"LPLIPAL1C180\",\n\"name\":\"lysophospholipase C1  n 18 0 \",\n\"metabolites\":{\n\"1agpc180_c\":-1.0,\n\"g3pc_c\":1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"ocdca_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_20340\"\n},\n{\n\"id\":\"ADCYRS\",\n\"name\":\"adenosyl cobyric acid synthase\",\n\"metabolites\":{\n\"adcobdam_c\":-1.0,\n\"adcobhex_c\":1.0,\n\"adp_c\":4.0,\n\"atp_c\":-4.0,\n\"gln_L_c\":-4.0,\n\"glu_L_c\":4.0,\n\"h2o_c\":-4.0,\n\"h_c\":4.0,\n\"pi_c\":4.0\n},\n\"lower_bound\":0,\n\"upper_bound\":1000,\n\"gene_reaction_rule\":\"CQW49_02440\"\n},\n{\n\"id\":\"LPLIPAL1C181\",\n\"name\":\"lysophospholipase C1  n 18 1 \",\n\"metabolites\":{\n\"1agpc181_c\":-1.0,\n\"g3pc_c\":1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"ocdcea_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_20340\"\n},\n{\n\"id\":\"EX_DM_trnacys\",\n\"name\":\"exchange flux   tRNA Cys \",\n\"metabolites\":{\n\"trnacys_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"EX_no3_e\",\n\"name\":\"exchange flux   nitrate\",\n\"metabolites\":{\n\"no3_e\":-1.0\n},\n\"lower_bound\":-1000,\n\"upper_bound\":0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"ETOHDH\",\n\"name\":\"quinoprotein ethanol dehydrogenase\",\n\"metabolites\":{\n\"acald_p\":1.0,\n\"etoh_p\":-1.0,\n\"ficytc_c\":-2.0,\n\"focytc_c\":2.0,\n\"h_p\":2.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_14425 and CQW49_14440\"\n},\n{\n\"id\":\"ARGSL\",\n\"name\":\"argininosuccinate lyase\",\n\"metabolites\":{\n\"arg_L_c\":1.0,\n\"argsuc_c\":-1.0,\n\"fum_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_11950\"\n},\n{\n\"id\":\"PTHPS\",\n\"name\":\"6 pyruvoyl tetrahydrobiopterin synthase\",\n\"metabolites\":{\n\"6pthp_c\":1.0,\n\"ahdt_c\":-1.0,\n\"pppi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_17765\"\n},\n{\n\"id\":\"ENCOAI121\",\n\"name\":\"enoyl CoA isomerase  n 12 0 \",\n\"metabolites\":{\n\"cdd3ecoa_c\":1.0,\n\"dd2coa_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_15495 and CQW49_15500\"\n},\n{\n\"id\":\"ASPTRNAAMT\",\n\"name\":\"aspartyl tRNA amidotransferase\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"asntrna_c\":1.0,\n\"asptrna_asn_c\":-1.0,\n\"atp_c\":-1.0,\n\"gln_L_c\":-1.0,\n\"glu_L_c\":1.0,\n\"h2o_c\":-1.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"(CQW49_01110 and CQW49_01100 and CQW49_01095) or (CQW49_00575 and CQW49_11960 and CQW49_01095)\"\n},\n{\n\"id\":\"EX_o2_e\",\n\"name\":\"exchange flux   oxygen\",\n\"metabolites\":{\n\"o2_e\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"ACODA\",\n\"name\":\"acetylornithine deacetylase\",\n\"metabolites\":{\n\"ac_c\":1.0,\n\"acorn_c\":-1.0,\n\"h2o_c\":-1.0,\n\"orn_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_02995\"\n},\n{\n\"id\":\"ENCOAI122\",\n\"name\":\"enoyl CoA isomerase  n 12 1 \",\n\"metabolites\":{\n\"3cdd5ecoa_c\":1.0,\n\"t2cdd5ecoa_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_15495 and CQW49_15500\"\n},\n{\n\"id\":\"RZ5PP\",\n\"name\":\"a ribazole 5  phosphate phosphatase\",\n\"metabolites\":{\n\"5prdmbz_c\":-1.0,\n\"h2o_c\":-1.0,\n\"pi_c\":1.0,\n\"rdmbzi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"ASPTRS\",\n\"name\":\"aspartate tRNA synthetase\",\n\"metabolites\":{\n\"amp_c\":1.0,\n\"asp_L_c\":-1.0,\n\"asptrna_c\":1.0,\n\"atp_c\":-1.0,\n\"ppi_c\":1.0,\n\"trnaasp_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_19795\"\n},\n{\n\"id\":\"NNAMr\",\n\"name\":\"nicotinamidase\",\n\"metabolites\":{\n\"h2o_c\":-1.0,\n\"nac_c\":1.0,\n\"ncam_c\":-1.0,\n\"nh4_c\":1.0\n},\n\"lower_bound\":0,\n\"upper_bound\":1000,\n\"gene_reaction_rule\":\"CQW49_12045\"\n},\n{\n\"id\":\"UDPG4E\",\n\"name\":\"UDP glucose 4 epimerase\",\n\"metabolites\":{\n\"udpg_c\":-1.0,\n\"udpgal_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_16595\"\n},\n{\n\"id\":\"ACGS\",\n\"name\":\"N acetylglutamate synthase\",\n\"metabolites\":{\n\"accoa_c\":-1.0,\n\"acglu_c\":1.0,\n\"coa_c\":1.0,\n\"glu_L_c\":-1.0,\n\"h_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_12715\"\n},\n{\n\"id\":\"ACOAD181\",\n\"name\":\"acyl CoA dehydrogenase  n 18 1 \",\n\"metabolites\":{\n\"fad_c\":-1.0,\n\"fadh2_c\":1.0,\n\"odecoa_c\":-1.0,\n\"t3coctd11ecoa_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_15490 or CQW49_03065 or CQW49_11850\"\n},\n{\n\"id\":\"Ktex\",\n\"name\":\"potassium transport via diffusion  extracellular to periplasm \",\n\"metabolites\":{\n\"k_e\":-1.0,\n\"k_p\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"HACOADH181\",\n\"name\":\"3 hydroxyacyl CoA dehydrogenase  n 18 1 \",\n\"metabolites\":{\n\"3hcoctd11ecoa_c\":-1.0,\n\"3ococtd11ecoa_c\":1.0,\n\"h_c\":1.0,\n\"nad_c\":-1.0,\n\"nadh_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_15495 and CQW49_15500\"\n},\n{\n\"id\":\"HACOADH180\",\n\"name\":\"3 hydroxyacyl CoA epimerase  n 18 0 \",\n\"metabolites\":{\n\"3hodcoa_c\":-1.0,\n\"R_3hoctdccoa_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_15495 and CQW49_15500\"\n},\n{\n\"id\":\"HTHRPD\",\n\"name\":\"4 hydroxy L threonine phosphate dehydrogenase  NAD dependent\",\n\"metabolites\":{\n\"ao4pob_c\":1.0,\n\"h_c\":1.0,\n\"nad_c\":-1.0,\n\"nadh_c\":1.0,\n\"phthr_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_11310\"\n},\n{\n\"id\":\"ACGK\",\n\"name\":\"acetylglutamate kinase\",\n\"metabolites\":{\n\"acg5p_c\":1.0,\n\"acglu_c\":-1.0,\n\"adp_c\":1.0,\n\"atp_c\":-1.0\n},\n\"lower_bound\":0,\n\"upper_bound\":1000,\n\"gene_reaction_rule\":\"CQW49_08615\"\n},\n{\n\"id\":\"FACOAE80\",\n\"name\":\"acyl CoA thioesterase II  n 8 0 \",\n\"metabolites\":{\n\"coa_c\":1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"occoa_c\":-1.0,\n\"octa_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_00725 or CQW49_04870 or CQW49_01990\"\n},\n{\n\"id\":\"CMPKDOT2\",\n\"name\":\"3 deoxy D manno octulosonic acid transferase 2\",\n\"metabolites\":{\n\"cmp_c\":1.0,\n\"cmpkdo_c\":-1.0,\n\"h_c\":1.0,\n\"kdolipid4_c\":1.0,\n\"lipidA_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_17605\"\n},\n{\n\"id\":\"CMPKDOT1\",\n\"name\":\"3 deoxy D manno octulosonic acid transferase 1\",\n\"metabolites\":{\n\"cmp_c\":1.0,\n\"cmpkdo_c\":-1.0,\n\"h_c\":1.0,\n\"kdo2lipid4_c\":1.0,\n\"kdolipid4_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_17605\"\n},\n{\n\"id\":\"HEMEDS2\",\n\"name\":\"heme d synthase\",\n\"metabolites\":{\n\"h2o2_c\":-1.0,\n\"h_c\":2.0,\n\"hemeD_c\":1.0,\n\"pheme_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"META1_3421\"\n},\n{\n\"id\":\"SPODM\",\n\"name\":\"superoxide dismutase\",\n\"metabolites\":{\n\"h2o2_c\":1.0,\n\"h_c\":-2.0,\n\"o2_c\":1.0,\n\"o2s_c\":-2.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_01280\"\n},\n{\n\"id\":\"PSSA161\",\n\"name\":\"phosphatidylserine synthase  n 16 1 \",\n\"metabolites\":{\n\"cdpdhdec9eg_c\":-1.0,\n\"cmp_c\":1.0,\n\"h_c\":1.0,\n\"ps161_c\":1.0,\n\"ser_L_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_03330\"\n},\n{\n\"id\":\"PSSA160\",\n\"name\":\"phosphatidylserine synthase  n 16 0 \",\n\"metabolites\":{\n\"cdpdhdecg_c\":-1.0,\n\"cmp_c\":1.0,\n\"h_c\":1.0,\n\"ps160_c\":1.0,\n\"ser_L_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_03330\"\n},\n{\n\"id\":\"GLYCOX3\",\n\"name\":\"glycine oxidase 3\",\n\"metabolites\":{\n\"glx_c\":1.0,\n\"h2o2_c\":1.0,\n\"h2o_c\":-1.0,\n\"mma_c\":1.0,\n\"o2_c\":-1.0,\n\"sarcs_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_14270\"\n},\n{\n\"id\":\"GLYCOX4\",\n\"name\":\"glycine oxidase 4\",\n\"metabolites\":{\n\"etgly_c\":-1.0,\n\"ethlam_c\":1.0,\n\"glx_c\":1.0,\n\"h2o2_c\":1.0,\n\"h2o_c\":-1.0,\n\"o2_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_14270\"\n},\n{\n\"id\":\"OXAtex\",\n\"name\":\"oxalate transport via diffusion  extracellular to periplasm \",\n\"metabolites\":{\n\"oxa_e\":-1.0,\n\"oxa_p\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"PPNCL2\",\n\"name\":\"phosphopantothenoylcysteine synthetase\",\n\"metabolites\":{\n\"4ppan_c\":-1.0,\n\"4ppcys_c\":1.0,\n\"cmp_c\":1.0,\n\"ctp_c\":-1.0,\n\"cys_L_c\":-1.0,\n\"h_c\":1.0,\n\"ppi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_21235\"\n},\n{\n\"id\":\"GLYCOX5\",\n\"name\":\"glycine oxidase 5\",\n\"metabolites\":{\n\"gly_c\":-1.0,\n\"h2o2_c\":1.0,\n\"imgly_c\":1.0,\n\"o2_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_14270\"\n},\n{\n\"id\":\"UHGADA\",\n\"name\":\"UDP 3 O acyl N acetylglucosamine deacetylase\",\n\"metabolites\":{\n\"ac_c\":1.0,\n\"h2o_c\":-1.0,\n\"u3aga_c\":-1.0,\n\"u3hga_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_11275\"\n},\n{\n\"id\":\"THRS\",\n\"name\":\"threonine synthase\",\n\"metabolites\":{\n\"h2o_c\":-1.0,\n\"phom_c\":-1.0,\n\"pi_c\":1.0,\n\"thr_L_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_10000\"\n},\n{\n\"id\":\"BB_RMN\",\n\"name\":\"Biomass flux   L rhamnose\",\n\"metabolites\":{\n\"dtdp_c\":1.0,\n\"dtdprmn_c\":-1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"rmn_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"METSr\",\n\"name\":\"methionine synthase reversible\",\n\"metabolites\":{\n\"5mthf_c\":-1.0,\n\"h_c\":1.0,\n\"hcys_L_c\":-1.0,\n\"met_L_c\":1.0,\n\"thf_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_19055\"\n},\n{\n\"id\":\"EX_DM_trnahis\",\n\"name\":\"exchange flux   tRNA His \",\n\"metabolites\":{\n\"trnahis_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"THRA\",\n\"name\":\"L threonine aldolase\",\n\"metabolites\":{\n\"acald_c\":1.0,\n\"gly_c\":1.0,\n\"thr_L_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"META1_3334\"\n},\n{\n\"id\":\"LPLIPAL1C161\",\n\"name\":\"lysophospholipase C1  n 16 1 \",\n\"metabolites\":{\n\"1agpc161_c\":-1.0,\n\"g3pc_c\":1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"hdcea_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_20340\"\n},\n{\n\"id\":\"HMBS\",\n\"name\":\"porphobilinogen deaminase\",\n\"metabolites\":{\n\"h2o_c\":-1.0,\n\"hmbil_c\":1.0,\n\"nh4_c\":4.0,\n\"ppbng_c\":-4.0\n},\n\"lower_bound\":0,\n\"upper_bound\":1000,\n\"gene_reaction_rule\":\"CQW49_06515\"\n},\n{\n\"id\":\"CYSTL\",\n\"name\":\"cystathionine beta lyase\",\n\"metabolites\":{\n\"cyst_L_c\":-1.0,\n\"h2o_c\":-1.0,\n\"hcys_L_c\":1.0,\n\"nh4_c\":1.0,\n\"pyr_c\":1.0\n},\n\"lower_bound\":0,\n\"upper_bound\":1000,\n\"gene_reaction_rule\":\"CQW49_00185\"\n},\n{\n\"id\":\"CYSSr\",\n\"name\":\"cysteine synthase\",\n\"metabolites\":{\n\"ac_c\":1.0,\n\"acser_c\":-1.0,\n\"cys_L_c\":1.0,\n\"h2s_c\":-1.0,\n\"h_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"(CQW49_00250 and CQW49_10340) or CQW49_00920 or CQW49_10340\"\n},\n{\n\"id\":\"ACOAD121\",\n\"name\":\"acyl CoA dehydrogenase  n 12 1 \",\n\"metabolites\":{\n\"cdd5ecoa_c\":-1.0,\n\"fad_c\":-1.0,\n\"fadh2_c\":1.0,\n\"t3cdd5ecoa_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_15490 or CQW49_03065 or CQW49_11850\"\n},\n{\n\"id\":\"CBIAT\",\n\"name\":\"cob I alamin adenosyltransferase\",\n\"metabolites\":{\n\"adocbi_c\":1.0,\n\"atp_c\":-1.0,\n\"cbi_c\":-1.0,\n\"h_c\":-1.0,\n\"pppi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_17855 or CQW49_06565\"\n},\n{\n\"id\":\"FMNAT\",\n\"name\":\"FMN adenylyltransferase\",\n\"metabolites\":{\n\"atp_c\":-1.0,\n\"fad_c\":1.0,\n\"fmn_c\":-1.0,\n\"h_c\":-1.0,\n\"ppi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_12610\"\n},\n{\n\"id\":\"ENCOAI101\",\n\"name\":\"enoyl CoA isomerase  n 10 0 \",\n\"metabolites\":{\n\"cd2ecoa_c\":1.0,\n\"dc2coa_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_15495 and CQW49_15500\"\n},\n{\n\"id\":\"PGLYCP\",\n\"name\":\"phosphoglycolate phosphatase\",\n\"metabolites\":{\n\"2pglyc_c\":-1.0,\n\"glyclt_c\":1.0,\n\"h2o_c\":-1.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_14220\"\n},\n{\n\"id\":\"KARA2\",\n\"name\":\"2 aceto 2 hydroxy butyrate reductoisomerase\",\n\"metabolites\":{\n\"23dhmp_c\":1.0,\n\"2ahbut_c\":-1.0,\n\"h_c\":-1.0,\n\"nadp_c\":1.0,\n\"nadph_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_06800\"\n},\n{\n\"id\":\"HACOADH160\",\n\"name\":\"3 hydroxyacyl CoA epimerase  n 16 0 \",\n\"metabolites\":{\n\"3hhdcoa_c\":-1.0,\n\"R_3hhdccoa_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_15495 and CQW49_15500\"\n},\n{\n\"id\":\"HACOADH161\",\n\"name\":\"3 hydroxyacyl CoA dehydrogenase  n 16 1 \",\n\"metabolites\":{\n\"3hchd9ecoa_c\":-1.0,\n\"3ochd9ecoa_c\":1.0,\n\"h_c\":1.0,\n\"nad_c\":-1.0,\n\"nadh_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_15495 and CQW49_15500\"\n},\n{\n\"id\":\"DHPS2\",\n\"name\":\"dihydropteroate synthase\",\n\"metabolites\":{\n\"4abz_c\":-1.0,\n\"6hmhptpp_c\":-1.0,\n\"dhpt_c\":1.0,\n\"ppi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_10270\"\n},\n{\n\"id\":\"SADT\",\n\"name\":\"sulfate adenylyltransferase\",\n\"metabolites\":{\n\"aps_c\":1.0,\n\"atp_c\":-1.0,\n\"h_c\":-1.0,\n\"ppi_c\":1.0,\n\"so4_c\":-1.0\n},\n\"lower_bound\":0,\n\"upper_bound\":1000,\n\"gene_reaction_rule\":\"CQW49_00355 and CQW49_00350\"\n},\n{\n\"id\":\"PC20M\",\n\"name\":\"precorrin 2 C 20  methyltransferase\",\n\"metabolites\":{\n\"ahcys_c\":1.0,\n\"amet_c\":-1.0,\n\"dscl_c\":-1.0,\n\"h_c\":1.0,\n\"pre3a_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"META1_1325\"\n},\n{\n\"id\":\"KARA1\",\n\"name\":\"2 acetolactate reductoisomerase\",\n\"metabolites\":{\n\"23dhmb_c\":1.0,\n\"alac_S_c\":-1.0,\n\"h_c\":-1.0,\n\"nadp_c\":1.0,\n\"nadph_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_06800\"\n},\n{\n\"id\":\"2DRIBOAtex\",\n\"name\":\"2 deoxy D ribonate transport via diffusion  extracellular to periplasm \",\n\"metabolites\":{\n\"2driboa_e\":-1.0,\n\"2driboa_p\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"IPPMIb\",\n\"name\":\"3 isopropylmalate isomerase\",\n\"metabolites\":{\n\"2ippa_c\":-1.0,\n\"3c3hmp_c\":1.0,\n\"h2o_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_06800 or (CQW49_15985 and CQW49_13290)\"\n},\n{\n\"id\":\"G1PTT\",\n\"name\":\"glucose 1 phosphate thymidylyltransferase\",\n\"metabolites\":{\n\"dtdpglu_c\":1.0,\n\"dttp_c\":-1.0,\n\"g1p_c\":-1.0,\n\"h_c\":-1.0,\n\"ppi_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_06230\"\n},\n{\n\"id\":\"SKMK\",\n\"name\":\"shikimate kinase\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"h_c\":1.0,\n\"skm3p_c\":1.0,\n\"skm_c\":-1.0\n},\n\"lower_bound\":0,\n\"upper_bound\":1000,\n\"gene_reaction_rule\":\"CQW49_06775\"\n},\n{\n\"id\":\"EX_fum_e\",\n\"name\":\"exchange flux   fumarate\",\n\"metabolites\":{\n\"fum_e\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":0.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"PC6AR\",\n\"name\":\"precorrin 6A reductase\",\n\"metabolites\":{\n\"h_c\":-1.0,\n\"nadp_c\":1.0,\n\"nadph_c\":-1.0,\n\"pre6a_c\":-1.0,\n\"pre6b_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_09605\"\n},\n{\n\"id\":\"3OAR181\",\n\"name\":\"3 oxoacyl  acyl carrier protein  reductase  n 18 1 \",\n\"metabolites\":{\n\"3hcvac11eACP_c\":1.0,\n\"3ocvac11eACP_c\":-1.0,\n\"h_c\":-1.0,\n\"nadp_c\":1.0,\n\"nadph_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_16140 or CQW49_17680\"\n},\n{\n\"id\":\"GLYCK2\",\n\"name\":\"glycerate kinase\",\n\"metabolites\":{\n\"2pg_c\":1.0,\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"glyc_R_c\":-1.0,\n\"h_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_12245\"\n},\n{\n\"id\":\"H2O2tpp\",\n\"name\":\"H2O2 transport via diffusion  periplasm to cytoplasm \",\n\"metabolites\":{\n\"h2o2_c\":1.0,\n\"h2o2_p\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"H2MB4PRD2\",\n\"name\":\"1 hydroxy 2 methyl 2  E  butenyl 4 diphosphate reductase 2\",\n\"metabolites\":{\n\"h2mb4p_c\":-1.0,\n\"h2o_c\":1.0,\n\"h_c\":-1.0,\n\"ipdp_c\":1.0,\n\"nadp_c\":1.0,\n\"nadph_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_17525\"\n},\n{\n\"id\":\"EX_DM_trnapro\",\n\"name\":\"exchange flux   tRNA Pro \",\n\"metabolites\":{\n\"trnapro_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"U23GAAT\",\n\"name\":\"UDP 3 O  3 hydroxymyristoyl glucosamine N acetyltransferase\",\n\"metabolites\":{\n\"3hmrsACP_c\":-1.0,\n\"ACP_c\":1.0,\n\"h_c\":1.0,\n\"u23ga_c\":1.0,\n\"u3hga_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_00470\"\n},\n{\n\"id\":\"THMBTHIC\",\n\"name\":\"thiamine biosynthesis protein thiC\",\n\"metabolites\":{\n\"4ampm_c\":1.0,\n\"air_c\":-1.0,\n\"amet_c\":-1.0,\n\"dad_2_c\":1.0,\n\"met_L_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_04940\"\n},\n{\n\"id\":\"ACOAD141\",\n\"name\":\"acyl CoA dehydrogenase  n 14 1 \",\n\"metabolites\":{\n\"fad_c\":-1.0,\n\"fadh2_c\":1.0,\n\"t3ctd7ecoa_c\":1.0,\n\"tdecoa_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_15490 or CQW49_03065 or CQW49_11850\"\n},\n{\n\"id\":\"DPR\",\n\"name\":\"2 dehydropantoate 2 reductase\",\n\"metabolites\":{\n\"2dhp_c\":-1.0,\n\"h_c\":-1.0,\n\"nadp_c\":1.0,\n\"nadph_c\":-1.0,\n\"pant_R_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_01170\"\n},\n{\n\"id\":\"SERGLXAT\",\n\"name\":\"L serine glyoxylate aminotransferase\",\n\"metabolites\":{\n\"glx_c\":-1.0,\n\"gly_c\":1.0,\n\"hpyr_c\":1.0,\n\"ser_L_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_12200\"\n},\n{\n\"id\":\"EX_2kdrib_e\",\n\"name\":\"exchange flux   2 deoxy D ribose\",\n\"metabolites\":{\n\"2kdrib_e\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":0.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"3OAR180\",\n\"name\":\"3 oxoacyl  acyl carrier protein  reductase  n 18 0 \",\n\"metabolites\":{\n\"3hoctaACP_c\":1.0,\n\"3ooctdACP_c\":-1.0,\n\"h_c\":-1.0,\n\"nadp_c\":1.0,\n\"nadph_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_16140 or CQW49_17680\"\n},\n{\n\"id\":\"HACOADH141\",\n\"name\":\"3 hydroxyacyl CoA dehydrogenase  n 14 1 \",\n\"metabolites\":{\n\"3hctd7ecoa_c\":-1.0,\n\"3octd7ecoa_c\":1.0,\n\"h_c\":1.0,\n\"nad_c\":-1.0,\n\"nadh_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_15495 and CQW49_15500\"\n},\n{\n\"id\":\"5DGLCNt2rpp\",\n\"name\":\"5 dehydro D gluconate transporter  inferred from physiology \",\n\"metabolites\":{\n\"5dglcn_c\":1.0,\n\"5dglcn_p\":-1.0,\n\"h_c\":1.0,\n\"h_p\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"MPTFALDA\",\n\"name\":\"H4MPT dependent formaldehyde activating\",\n\"metabolites\":{\n\"fald_c\":-1.0,\n\"h2o_c\":1.0,\n\"h4mpt_c\":-1.0,\n\"mlh4mpt_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_13480\"\n},\n{\n\"id\":\"3HBCD\",\n\"name\":\" R  3 hydroxybutyryl CoA dehydratase\",\n\"metabolites\":{\n\"b2coa_c\":1.0,\n\"h2o_c\":1.0,\n\"r3hbcoa_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_12855\"\n},\n{\n\"id\":\"PMDPHT\",\n\"name\":\"pyrimidine phosphatase\",\n\"metabolites\":{\n\"4r5au_c\":1.0,\n\"5aprbu_c\":-1.0,\n\"h2o_c\":-1.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"CO2tex\",\n\"name\":\"CO2 transport via diffusion  extracellular to periplasm \",\n\"metabolites\":{\n\"co2_e\":-1.0,\n\"co2_p\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"NTD10\",\n\"name\":\"5  nucleotidase  XMP \",\n\"metabolites\":{\n\"h2o_c\":-1.0,\n\"pi_c\":1.0,\n\"xmp_c\":-1.0,\n\"xtsn_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_02190\"\n},\n{\n\"id\":\"NTD11\",\n\"name\":\"5  nucleotidase  IMP \",\n\"metabolites\":{\n\"h2o_c\":-1.0,\n\"imp_c\":-1.0,\n\"ins_c\":1.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_02190\"\n},\n{\n\"id\":\"EX_lyxnt_e\",\n\"name\":\"exchange flux   L lyxonate\",\n\"metabolites\":{\n\"lyxnt_e\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":0.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"ACKr\",\n\"name\":\"acetate kinase\",\n\"metabolites\":{\n\"ac_c\":-1.0,\n\"actp_c\":1.0,\n\"adp_c\":1.0,\n\"atp_c\":-1.0\n},\n\"lower_bound\":0,\n\"upper_bound\":1000,\n\"gene_reaction_rule\":\"CQW49_15765\"\n},\n{\n\"id\":\"ACLS\",\n\"name\":\"acetolactate synthase\",\n\"metabolites\":{\n\"alac_S_c\":1.0,\n\"co2_c\":1.0,\n\"h_c\":-1.0,\n\"pyr_c\":-2.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_06820 and CQW49_06815\"\n},\n{\n\"id\":\"FALDtpp\",\n\"name\":\"formaldehyde transport via diffusion  periplasm to cytoplasm \",\n\"metabolites\":{\n\"fald_c\":1.0,\n\"fald_p\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"HSDyi\",\n\"name\":\"homoserine dehydrogenase\",\n\"metabolites\":{\n\"aspsa_c\":-1.0,\n\"h_c\":-1.0,\n\"hom_L_c\":1.0,\n\"nadp_c\":1.0,\n\"nadph_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_20755\"\n},\n{\n\"id\":\"ATPPRTr\",\n\"name\":\"ATP phosphoribosyltransferase\",\n\"metabolites\":{\n\"atp_c\":-1.0,\n\"ppi_c\":1.0,\n\"prbatp_c\":1.0,\n\"prpp_c\":-1.0\n},\n\"lower_bound\":0,\n\"upper_bound\":1000,\n\"gene_reaction_rule\":\"CQW49_02680\"\n},\n{\n\"id\":\"NNDPR\",\n\"name\":\"quinolinate phosphoribosyltransferase\",\n\"metabolites\":{\n\"co2_c\":1.0,\n\"h_c\":-2.0,\n\"nicrnt_c\":1.0,\n\"ppi_c\":1.0,\n\"prpp_c\":-1.0,\n\"quln_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_10305\"\n},\n{\n\"id\":\"NO3Ras\",\n\"name\":\"nitrate reductase assimilatory\",\n\"metabolites\":{\n\"h2o_c\":1.0,\n\"h_c\":-1.0,\n\"nadp_c\":1.0,\n\"nadph_c\":-1.0,\n\"no2_c\":1.0,\n\"no3_c\":-1.0\n},\n\"lower_bound\":0,\n\"upper_bound\":0,\n\"gene_reaction_rule\":\"CQW49_19300 or CQW49_17890\"\n},\n{\n\"id\":\"EX_DM_trnaarg\",\n\"name\":\"exchange flux   tRNA Arg \",\n\"metabolites\":{\n\"trnaarg_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"PPTT\",\n\"name\":\"octaprenyl diphosphate synthase 2\",\n\"metabolites\":{\n\"hexdp_c\":1.0,\n\"ipdp_c\":-1.0,\n\"pendp_c\":-1.0,\n\"ppi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_18820\"\n},\n{\n\"id\":\"PTRCtex\",\n\"name\":\"putrescine transport via diffusion  extracellular to periplasm \",\n\"metabolites\":{\n\"ptrc_e\":-1.0,\n\"ptrc_p\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"GLUSy\",\n\"name\":\"glutamate synthase 2\",\n\"metabolites\":{\n\"akg_c\":-1.0,\n\"gln_L_c\":-1.0,\n\"glu_L_c\":2.0,\n\"h_c\":-1.0,\n\"nadp_c\":1.0,\n\"nadph_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_02655 and CQW49_02775\"\n},\n{\n\"id\":\"LPLIPAL2E180\",\n\"name\":\"lysophospholipase E1  n 18 0 \",\n\"metabolites\":{\n\"1agpe180_c\":-1.0,\n\"g3pe_c\":1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"ocdca_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_20340\"\n},\n{\n\"id\":\"EX_succ_e\",\n\"name\":\"exchange flux   succinate\",\n\"metabolites\":{\n\"succ_e\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":0.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"LPLIPAL2E181\",\n\"name\":\"lysophospholipase E2  n 18 1 \",\n\"metabolites\":{\n\"2agpe181_c\":-1.0,\n\"g3pe_c\":1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"ocdcea_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_20340\"\n},\n{\n\"id\":\"PIuabcpp\",\n\"name\":\"phosphate ABC transporter\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"pi_c\":2.0,\n\"pi_p\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_15945 and CQW49_15930 and CQW49_15935 and CQW49_15940\"\n},\n{\n\"id\":\"THMBIOS\",\n\"name\":\"thiamin biosynthesis 1\",\n\"metabolites\":{\n\"atp_c\":-1.0,\n\"h_c\":-1.0,\n\"ppi_c\":1.0,\n\"this_c\":-1.0,\n\"thisamp_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_14265\"\n},\n{\n\"id\":\"FE2t2pp\",\n\"name\":\"iron proton symport\",\n\"metabolites\":{\n\"fe2_c\":1.0,\n\"fe2_p\":-1.0,\n\"h_c\":1.0,\n\"h_p\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_10860 or CQW49_08305\"\n},\n{\n\"id\":\"NNATr\",\n\"name\":\"nicotinate nucleotide adenylyltransferase\",\n\"metabolites\":{\n\"atp_c\":-1.0,\n\"dnad_c\":1.0,\n\"h_c\":-1.0,\n\"nicrnt_c\":-1.0,\n\"ppi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_15690\"\n},\n{\n\"id\":\"EX_DM_trnalys\",\n\"name\":\"exchange flux   tRNA Lys \",\n\"metabolites\":{\n\"trnalys_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"ARAB_Dtex\",\n\"name\":\"D arabinose transport via diffusion  extracellular to periplasm \",\n\"metabolites\":{\n\"arab_D_e\":-1.0,\n\"arab_D_p\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"ALDD2y\",\n\"name\":\"acetyldehyde dehydrogenase\",\n\"metabolites\":{\n\"ac_c\":1.0,\n\"acald_c\":-1.0,\n\"h2o_c\":-1.0,\n\"h_c\":2.0,\n\"nadp_c\":-1.0,\n\"nadph_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_11425\"\n},\n{\n\"id\":\"HPTRED\",\n\"name\":\"dihydropteridine reductase\",\n\"metabolites\":{\n\"h2pt_c\":1.0,\n\"h4pt_c\":-1.0,\n\"h_c\":1.0,\n\"nadp_c\":-1.0,\n\"nadph_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_12455\"\n},\n{\n\"id\":\"PHYNDH2_e\",\n\"name\":\"phytoene dehydrogenase 2  extracellular \",\n\"metabolites\":{\n\"h2o_e\":2.0,\n\"o2_e\":-1.0,\n\"oxEA_e\":1.0,\n\"phyflun_e\":-1.0,\n\"rdEA_e\":-1.0,\n\"zcar_e\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_08235\"\n},\n{\n\"id\":\"MPTSA\",\n\"name\":\"molybdopterin synthase activations\",\n\"metabolites\":{\n\"Ssact_c\":-1.0,\n\"h_c\":2.0,\n\"mptS_c\":-1.0,\n\"mptSs_c\":1.0,\n\"uSsact_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"TRDR\",\n\"name\":\"thioredoxin reductase\",\n\"metabolites\":{\n\"h_c\":1.0,\n\"nadp_c\":1.0,\n\"nadph_c\":-1.0,\n\"trdox_c\":-1.0,\n\"trdrd_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_10575\"\n},\n{\n\"id\":\"FE2abcpp\",\n\"name\":\"iron ABC transporter\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"fe2_c\":1.0,\n\"fe2_p\":-1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"(CQW49_17840 and CQW49_17860 and CQW49_17835) or (CQW49_09670 and CQW49_09665 and CQW49_09660)\"\n},\n{\n\"id\":\"ZCARDS_e\",\n\"name\":\"zeta carotene desaturase 1  extracullular \",\n\"metabolites\":{\n\"h2o_e\":2.0,\n\"neuropn_e\":1.0,\n\"o2_e\":-1.0,\n\"oxEA_e\":1.0,\n\"rdEA_e\":-1.0,\n\"zcar_e\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_08235\"\n},\n{\n\"id\":\"3OAS100\",\n\"name\":\"3 oxoacyl  acyl carrier protein  synthase  n 10 0 \",\n\"metabolites\":{\n\"3odecACP_c\":1.0,\n\"ACP_c\":1.0,\n\"co2_c\":1.0,\n\"h_c\":-1.0,\n\"malACP_c\":-1.0,\n\"ocACP_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_03730 or CQW49_17690 or CQW49_09315\"\n},\n{\n\"id\":\"PGAMT\",\n\"name\":\"phosphoglucosamine mutase\",\n\"metabolites\":{\n\"gam1p_c\":-1.0,\n\"gam6p_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_20395\"\n},\n{\n\"id\":\"OMBZLM\",\n\"name\":\"2 octaprenyl 6 methoxy 1 4 benzoquinone methylase\",\n\"metabolites\":{\n\"2ombzl_c\":-1.0,\n\"2ommbl_c\":1.0,\n\"ahcys_c\":1.0,\n\"amet_c\":-1.0,\n\"h_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_18430\"\n},\n{\n\"id\":\"ETHMALCOAEPM\",\n\"name\":\"ethylmalonyl CoA epimerase\",\n\"metabolites\":{\n\"2Rethmalcoa_c\":1.0,\n\"2Sethmalcoa_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_05270\"\n},\n{\n\"id\":\"RBFK\",\n\"name\":\"riboflavin kinase\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"fmn_c\":1.0,\n\"h_c\":1.0,\n\"ribflv_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_12610\"\n},\n{\n\"id\":\"MNt2pp\",\n\"name\":\"manganese proton symport\",\n\"metabolites\":{\n\"h_c\":1.0,\n\"h_p\":-1.0,\n\"mn2_c\":1.0,\n\"mn2_p\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_10860 or CQW49_08305\"\n},\n{\n\"id\":\"HBZOPT\",\n\"name\":\"4 hydroxybenzoate octaprenyltransferase\",\n\"metabolites\":{\n\"3ophb_c\":1.0,\n\"4hbz_c\":-1.0,\n\"octdp_c\":-1.0,\n\"ppi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_17580\"\n},\n{\n\"id\":\"LPLIPAL2E160\",\n\"name\":\"lysophospholipase E2  n 16 0 \",\n\"metabolites\":{\n\"2agpe160_c\":-1.0,\n\"g3pe_c\":1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"hdca_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_20340\"\n},\n{\n\"id\":\"DHNPA2\",\n\"name\":\"dihydroneopterin aldolase\",\n\"metabolites\":{\n\"6hmhpt_c\":1.0,\n\"dhnpt_c\":-1.0,\n\"gcald_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"META1_1744\"\n},\n{\n\"id\":\"LPLIPAL2E161\",\n\"name\":\"lysophospholipase E2  n 16 1 \",\n\"metabolites\":{\n\"2agpe161_c\":-1.0,\n\"g3pe_c\":1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"hdcea_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_20340\"\n},\n{\n\"id\":\"PHYNDH\",\n\"name\":\"phytoene dehydrogenase 1\",\n\"metabolites\":{\n\"h2o_c\":2.0,\n\"o2_c\":-1.0,\n\"oxEA_c\":1.0,\n\"phyflun_c\":1.0,\n\"phyn_c\":-1.0,\n\"rdEA_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"META1_3219 or META1_3670\"\n},\n{\n\"id\":\"EX_DM_trnatyr\",\n\"name\":\"exchange flux   tRNA Tyr \",\n\"metabolites\":{\n\"trnatyr_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"EX_lyx_L_e\",\n\"name\":\"exchange flux   L lyxose\",\n\"metabolites\":{\n\"lyx_L_e\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":0.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"CHRPL\",\n\"name\":\"chorismate lyase\",\n\"metabolites\":{\n\"4hbz_c\":1.0,\n\"chor_c\":-1.0,\n\"pyr_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"SERAT\",\n\"name\":\"serine acetyltransferase\",\n\"metabolites\":{\n\"accoa_c\":-1.0,\n\"acser_c\":1.0,\n\"coa_c\":1.0,\n\"ser_L_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_00250 or CQW49_08660 or (CQW49_00250 and CQW49_10340)\"\n},\n{\n\"id\":\"PPCOAC\",\n\"name\":\"propionyl CoA carboxylase 1\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"h_c\":1.0,\n\"hco3_c\":-1.0,\n\"mmcoa_S_c\":1.0,\n\"pi_c\":1.0,\n\"ppcoa_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_20805 and CQW49_16085\"\n},\n{\n\"id\":\"H2O2syn\",\n\"name\":\"NADPH oxidoreductase  OYE \",\n\"metabolites\":{\n\"h2o2_c\":1.0,\n\"h_c\":-1.0,\n\"nadp_c\":1.0,\n\"nadph_c\":-1.0,\n\"o2_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_02410\"\n},\n{\n\"id\":\"TYRTRS\",\n\"name\":\"tyrosine tRNA synthetase\",\n\"metabolites\":{\n\"amp_c\":1.0,\n\"atp_c\":-1.0,\n\"ppi_c\":1.0,\n\"trnatyr_c\":-1.0,\n\"tyr_L_c\":-1.0,\n\"tyrtrna_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_02255\"\n},\n{\n\"id\":\"2AGPEAT181acp\",\n\"name\":\"2 acylglycerophosphoethanolamine acyltransferase  n 18 1 \",\n\"metabolites\":{\n\"2agpe181_c\":-1.0,\n\"ACP_c\":1.0,\n\"octeACP_c\":-1.0,\n\"pe181_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_12415\"\n},\n{\n\"id\":\"PMANM\",\n\"name\":\"phosphomannomutase\",\n\"metabolites\":{\n\"man1p_c\":-1.0,\n\"man6p_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_16590\"\n},\n{\n\"id\":\"NTD9\",\n\"name\":\"5  nucleotidase  GMP \",\n\"metabolites\":{\n\"gmp_c\":-1.0,\n\"gsn_c\":1.0,\n\"h2o_c\":-1.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_02190\"\n},\n{\n\"id\":\"HFACOAE180\",\n\"name\":\"acyl CoA thioesterase II  n h18 0 \",\n\"metabolites\":{\n\"R_3hoctdc_c\":1.0,\n\"R_3hoctdccoa_c\":-1.0,\n\"coa_c\":1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_00725 or CQW49_04870 or CQW49_01990\"\n},\n{\n\"id\":\"NTD7\",\n\"name\":\"5  nucleotidase  AMP \",\n\"metabolites\":{\n\"adn_c\":1.0,\n\"amp_c\":-1.0,\n\"h2o_c\":-1.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_02190\"\n},\n{\n\"id\":\"EX_DM_rbrdxOX\",\n\"name\":\"exchange flux   oxidized rubredoxin\",\n\"metabolites\":{\n\"rbrdxOX_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"L_LACtex\",\n\"name\":\" S  lactate transport via diffusion  extracellular to periplasm \",\n\"metabolites\":{\n\"lac_L_e\":-1.0,\n\"lac_L_p\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"UDPDPS5\",\n\"name\":\"undecaprenyl diphosphate synthase 5\",\n\"metabolites\":{\n\"dtpchptpp_c\":-1.0,\n\"dtpcoctpp_c\":1.0,\n\"ipdp_c\":-1.0,\n\"ppi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_00445\"\n},\n{\n\"id\":\"UDPDPS6\",\n\"name\":\"undecaprenyl diphosphate synthase 6\",\n\"metabolites\":{\n\"dtpcnonpp_c\":1.0,\n\"dtpcoctpp_c\":-1.0,\n\"ipdp_c\":-1.0,\n\"ppi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_00445\"\n},\n{\n\"id\":\"UDPDPS3\",\n\"name\":\"undecaprenyl diphosphate synthase 3\",\n\"metabolites\":{\n\"dtpchxapp_c\":1.0,\n\"dtpcpentpp_c\":-1.0,\n\"ipdp_c\":-1.0,\n\"ppi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_00445\"\n},\n{\n\"id\":\"ENO\",\n\"name\":\"enolase\",\n\"metabolites\":{\n\"2pg_c\":-1.0,\n\"h2o_c\":1.0,\n\"pep_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_08625\"\n},\n{\n\"id\":\"UDPDPS4\",\n\"name\":\"undecaprenyl diphosphate synthase 4\",\n\"metabolites\":{\n\"dtpchptpp_c\":1.0,\n\"dtpchxapp_c\":-1.0,\n\"ipdp_c\":-1.0,\n\"ppi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_00445\"\n},\n{\n\"id\":\"MME\",\n\"name\":\"methylmalonyl CoA epimerase\",\n\"metabolites\":{\n\"mmcoa_R_c\":1.0,\n\"mmcoa_S_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_05270\"\n},\n{\n\"id\":\"CYRDAAT\",\n\"name\":\"cob I yrinic acid a c diamide adenosyltransferase\",\n\"metabolites\":{\n\"adcobdam_c\":1.0,\n\"atp_c\":-1.0,\n\"co1dam_c\":-1.0,\n\"h_c\":-1.0,\n\"pppi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_17855\"\n},\n{\n\"id\":\"H2Otpp\",\n\"name\":\"H2O transport via aquaporin\",\n\"metabolites\":{\n\"h2o_c\":1.0,\n\"h2o_p\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"META1_3809\"\n},\n{\n\"id\":\"UDPDPS9\",\n\"name\":\"undecaprenyl diphosphate synthase 8\",\n\"metabolites\":{\n\"dtpcdcpp_c\":-1.0,\n\"dtpcudcpp_c\":1.0,\n\"ipdp_c\":-1.0,\n\"ppi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_00445\"\n},\n{\n\"id\":\"UDPDPS7\",\n\"name\":\"undecaprenyl diphosphate synthase 7\",\n\"metabolites\":{\n\"dtpcdcpp_c\":1.0,\n\"dtpcnonpp_c\":-1.0,\n\"ipdp_c\":-1.0,\n\"ppi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_00445\"\n},\n{\n\"id\":\"GHMT2r\",\n\"name\":\"serine hydroxymethyltransferase\",\n\"metabolites\":{\n\"gly_c\":-1.0,\n\"h2o_c\":-1.0,\n\"mlthf_c\":-1.0,\n\"ser_L_c\":1.0,\n\"thf_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_06365\"\n},\n{\n\"id\":\"UDPDPS8\",\n\"name\":\"undecaprenyl diphosphate synthase 2\",\n\"metabolites\":{\n\"dtpcpentpp_c\":1.0,\n\"ipdp_c\":-1.0,\n\"ppi_c\":1.0,\n\"ttc_ggdp_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_00445\"\n},\n{\n\"id\":\"3OAS121\",\n\"name\":\"3 oxoacyl  acyl carrier protein  synthase  n 12 1 \",\n\"metabolites\":{\n\"3ocddec5eACP_c\":1.0,\n\"ACP_c\":1.0,\n\"cdec3eACP_c\":-1.0,\n\"co2_c\":1.0,\n\"h_c\":-1.0,\n\"malACP_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_03730 or CQW49_17690 or CQW49_09315\"\n},\n{\n\"id\":\"3OAS120\",\n\"name\":\"3 oxoacyl  acyl carrier protein  synthase  n 12 0 \",\n\"metabolites\":{\n\"3oddecACP_c\":1.0,\n\"ACP_c\":1.0,\n\"co2_c\":1.0,\n\"dcaACP_c\":-1.0,\n\"h_c\":-1.0,\n\"malACP_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_03730 or CQW49_17690 or CQW49_09315\"\n},\n{\n\"id\":\"MMM2r\",\n\"name\":\"methylmalonyl CoA mutase\",\n\"metabolites\":{\n\"mmcoa_R_c\":-1.0,\n\"succoa_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_12550 or CQW49_17450\"\n},\n{\n\"id\":\"AACOAR\",\n\"name\":\"acetoacetyl CoA reductase 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CQW49_15500\"\n},\n{\n\"id\":\"BB_ACGAM\",\n\"name\":\"Biomass flux   N acetyl D glucosamine\",\n\"metabolites\":{\n\"acgam_c\":1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"uacgam_c\":-1.0,\n\"udp_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"ECOAH3\",\n\"name\":\"enoyl CoA hydratase  n 8 0 \",\n\"metabolites\":{\n\"3hocoa_c\":1.0,\n\"h2o_c\":-1.0,\n\"oc2coa_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_15495 and CQW49_15500\"\n},\n{\n\"id\":\"ECOAH4\",\n\"name\":\"enoyl CoA hydratase  n 10 0 \",\n\"metabolites\":{\n\"3hdcoa_c\":1.0,\n\"dc2coa_c\":-1.0,\n\"h2o_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_15495 and CQW49_15500\"\n},\n{\n\"id\":\"AOXSr\",\n\"name\":\"7 keto 8 aminopelargonic acid synthetase\",\n\"metabolites\":{\n\"8aonn_c\":1.0,\n\"ala_L_c\":-1.0,\n\"co2_c\":1.0,\n\"coa_c\":1.0,\n\"h_c\":-1.0,\n\"pmcoa_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_01855\"\n},\n{\n\"id\":\"GARFT\",\n\"name\":\"phosphoribosylglycinamide formyltransferase\",\n\"metabolites\":{\n\"10fthf_c\":-1.0,\n\"fgam_c\":1.0,\n\"gar_c\":-1.0,\n\"h_c\":1.0,\n\"thf_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_01370\"\n},\n{\n\"id\":\"ECOAH7\",\n\"name\":\"enoyl CoA hydratase  n 16 0 \",\n\"metabolites\":{\n\"3hhdcoa_c\":1.0,\n\"h2o_c\":-1.0,\n\"hdd2coa_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_15495 and CQW49_15500\"\n},\n{\n\"id\":\"COBS2\",\n\"name\":\"cobalamin synthase\",\n\"metabolites\":{\n\"adocbl_c\":1.0,\n\"agdpcbi_c\":-1.0,\n\"gmp_c\":1.0,\n\"h_c\":1.0,\n\"rdmbzi_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_08875\"\n},\n{\n\"id\":\"ECOAH8\",\n\"name\":\"enoyl CoA hydratase  n 18 0 \",\n\"metabolites\":{\n\"3hodcoa_c\":1.0,\n\"h2o_c\":-1.0,\n\"od2coa_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_15495 and CQW49_15500\"\n},\n{\n\"id\":\"EX_DM_trnaasn\",\n\"name\":\"exchange flux   tRNA Asn \",\n\"metabolites\":{\n\"trnaasn_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"ECOAH1\",\n\"name\":\"3 hydroxybutyryl CoA dehydratase\",\n\"metabolites\":{\n\"3hbcoa_c\":-1.0,\n\"b2coa_c\":1.0,\n\"h2o_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"(CQW49_15495 and CQW49_15500) or CQW49_11715\"\n},\n{\n\"id\":\"ECOAH2\",\n\"name\":\"enoyl CoA hydratase  n 6 0 \",\n\"metabolites\":{\n\"3hhcoa_c\":1.0,\n\"h2o_c\":-1.0,\n\"hx2coa_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_15495 and CQW49_15500\"\n},\n{\n\"id\":\"EX_DM_trnaasp\",\n\"name\":\"exchange flux   tRNA Asp \",\n\"metabolites\":{\n\"trnaasp_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"CO2tpp\",\n\"name\":\"CO2 transport via diffusion  periplasm to cytoplasm \",\n\"metabolites\":{\n\"co2_c\":1.0,\n\"co2_p\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"FMNDESTRUC\",\n\"name\":\"flavin destructase\",\n\"metabolites\":{\n\"dmbzid_c\":2.0,\n\"e4p_c\":1.0,\n\"fmnh2_c\":-1.0,\n\"h2o_c\":1.0,\n\"o2_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"TDPGDH\",\n\"name\":\"dTDP glucose 4 6 dehydratase\",\n\"metabolites\":{\n\"dtdp4d6dg_c\":1.0,\n\"dtdpglu_c\":-1.0,\n\"h2o_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_06245\"\n},\n{\n\"id\":\"PHETA1\",\n\"name\":\"aromatic amino acid transaminase  PHE \",\n\"metabolites\":{\n\"akg_c\":1.0,\n\"glu_L_c\":-1.0,\n\"phe_L_c\":1.0,\n\"phpyr_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_08850\"\n},\n{\n\"id\":\"HISTP\",\n\"name\":\"histidinol phosphatase\",\n\"metabolites\":{\n\"h2o_c\":-1.0,\n\"hisp_c\":-1.0,\n\"histd_c\":1.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"META1_4121\"\n},\n{\n\"id\":\"ADCS\",\n\"name\":\"aminodeoxychorismate synthase\",\n\"metabolites\":{\n\"4adcho_c\":1.0,\n\"chor_c\":-1.0,\n\"gln_L_c\":-1.0,\n\"glu_L_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"META1_4284 and META1_4283\"\n},\n{\n\"id\":\"GALU\",\n\"name\":\"glucose 1 phosphate uridylyltransferase\",\n\"metabolites\":{\n\"g1p_c\":-1.0,\n\"h_c\":-1.0,\n\"ppi_c\":1.0,\n\"udpg_c\":1.0,\n\"utp_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_16600\"\n},\n{\n\"id\":\"CCRC\",\n\"name\":\"crotonyl CoA reductase carboxylase\",\n\"metabolites\":{\n\"2Sethmalcoa_c\":1.0,\n\"b2coa_c\":-1.0,\n\"co2_c\":-1.0,\n\"nadp_c\":1.0,\n\"nadph_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_03790\"\n},\n{\n\"id\":\"IPPS2\",\n\"name\":\"2 isopropylmalate synthase\",\n\"metabolites\":{\n\"2ippa_c\":1.0,\n\"3mob_c\":-1.0,\n\"accoa_c\":-1.0,\n\"coa_c\":1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_13130\"\n},\n{\n\"id\":\"HISTRS\",\n\"name\":\"histidyl tRNA synthetase\",\n\"metabolites\":{\n\"amp_c\":1.0,\n\"atp_c\":-1.0,\n\"his_L_c\":-1.0,\n\"histrna_c\":1.0,\n\"ppi_c\":1.0,\n\"trnahis_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_13045 or CQW49_02675\"\n},\n{\n\"id\":\"ACOAD2f\",\n\"name\":\"acyl CoA dehydrogenase  n 6 0 \",\n\"metabolites\":{\n\"fad_c\":-1.0,\n\"fadh2_c\":1.0,\n\"hx2coa_c\":1.0,\n\"hxcoa_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_15490 or CQW49_03065 or CQW49_11850\"\n},\n{\n\"id\":\"CU2abctpp\",\n\"name\":\"copper ABC transporter\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"cu2_c\":1.0,\n\"cu2_p\":-1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_05965\"\n},\n{\n\"id\":\"MMAtex\",\n\"name\":\"methylamine transport via diffusion  extracellular to periplasm \",\n\"metabolites\":{\n\"mma_e\":-1.0,\n\"mma_p\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"PEMT160\",\n\"name\":\"phosphatidylethanolamine N methyltransferase  n 16 0 \",\n\"metabolites\":{\n\"ahcys_c\":1.0,\n\"amet_c\":-1.0,\n\"h_c\":1.0,\n\"mpe160_c\":1.0,\n\"pe160_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_06905 or CQW49_20555\"\n},\n{\n\"id\":\"HACYLCOAEPI80\",\n\"name\":\"3 hydroxyacyl CoA epimerase  n 8 0 \",\n\"metabolites\":{\n\"3hocoa_c\":-1.0,\n\"R_3hocoa_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_15495 and CQW49_15500\"\n},\n{\n\"id\":\"ADCL\",\n\"name\":\"aminodeoxychorismate lyase\",\n\"metabolites\":{\n\"4abz_c\":1.0,\n\"4adcho_c\":-1.0,\n\"h_c\":1.0,\n\"pyr_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"PEMT161\",\n\"name\":\"phosphatidylethanolamine N methyltransferase  n 16 1 \",\n\"metabolites\":{\n\"ahcys_c\":1.0,\n\"amet_c\":-1.0,\n\"h_c\":1.0,\n\"mpe161_c\":1.0,\n\"pe161_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_06905 or CQW49_20555\"\n},\n{\n\"id\":\"EX_etha_e\",\n\"name\":\"exchange flux   ethanolamine\",\n\"metabolites\":{\n\"etha_e\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":0.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"CTPS2\",\n\"name\":\"CTP synthetase\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"ctp_c\":1.0,\n\"gln_L_c\":-1.0,\n\"glu_L_c\":1.0,\n\"h2o_c\":-1.0,\n\"h_c\":2.0,\n\"pi_c\":1.0,\n\"utp_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_18940\"\n},\n{\n\"id\":\"ACHBS\",\n\"name\":\"2 aceto 2 hydroxy butyrate synthase\",\n\"metabolites\":{\n\"2ahbut_c\":1.0,\n\"2obut_c\":-1.0,\n\"co2_c\":1.0,\n\"h_c\":-1.0,\n\"pyr_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_06820 and CQW49_06815\"\n},\n{\n\"id\":\"ORNTAC\",\n\"name\":\"glutamate N acetyltransferase\",\n\"metabolites\":{\n\"acglu_c\":1.0,\n\"acorn_c\":-1.0,\n\"glu_L_c\":-1.0,\n\"orn_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_12715\"\n},\n{\n\"id\":\"EX_ptrc_e\",\n\"name\":\"exchange flux   putrescine\",\n\"metabolites\":{\n\"ptrc_e\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":0.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"ACOAD3f\",\n\"name\":\"acyl CoA dehydrogenase  n 8 0 \",\n\"metabolites\":{\n\"fad_c\":-1.0,\n\"fadh2_c\":1.0,\n\"oc2coa_c\":1.0,\n\"occoa_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_15490 or CQW49_03065 or CQW49_11850\"\n},\n{\n\"id\":\"DMATT\",\n\"name\":\"geranyl diphosphate synthase\",\n\"metabolites\":{\n\"dmpp_c\":-1.0,\n\"grdp_c\":1.0,\n\"ipdp_c\":-1.0,\n\"ppi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_16515\"\n},\n{\n\"id\":\"FDHr\",\n\"name\":\"formate dehydrogenase\",\n\"metabolites\":{\n\"co2_c\":1.0,\n\"for_c\":-1.0,\n\"nad_c\":-1.0,\n\"nadh_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_16615 and CQW49_16630 and (CQW49_16625 or CQW49_16125) and CQW49_16635\"\n},\n{\n\"id\":\"ETMAt_e\",\n\"name\":\"ethylamine transport via diffusion  extracellular to periplasm \",\n\"metabolites\":{\n\"etma_e\":-1.0,\n\"etma_p\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"AROGDH\",\n\"name\":\"cyclohexadienyl dehydrogenase\",\n\"metabolites\":{\n\"arog_c\":-1.0,\n\"co2_c\":1.0,\n\"nad_c\":-1.0,\n\"nadh_c\":1.0,\n\"tyr_L_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_08845\"\n},\n{\n\"id\":\"GTPCI\",\n\"name\":\"GTP cyclohydrolase I\",\n\"metabolites\":{\n\"ahdt_c\":1.0,\n\"for_c\":1.0,\n\"gtp_c\":-1.0,\n\"h2o_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_20120 or CQW49_16285\"\n},\n{\n\"id\":\"SO4tex\",\n\"name\":\"sulfate transport via diffusion  extracellular to periplasm \",\n\"metabolites\":{\n\"so4_e\":-1.0,\n\"so4_p\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"LDH_D3\",\n\"name\":\"D lactate dehydrogenase  cytochrome \",\n\"metabolites\":{\n\"ficytc_c\":-2.0,\n\"focytc_c\":2.0,\n\"h_c\":2.0,\n\"lac_D_c\":-1.0,\n\"pyr_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_17075 or CQW49_10060\"\n},\n{\n\"id\":\"HSPMDS\",\n\"name\":\"homospermidine synthase 1\",\n\"metabolites\":{\n\"13dampp_c\":1.0,\n\"hspmd_c\":1.0,\n\"ptrc_c\":-1.0,\n\"spmd_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_06000\"\n},\n{\n\"id\":\"HSPMS\",\n\"name\":\"homospermidine synthase 2\",\n\"metabolites\":{\n\"hspmd_c\":1.0,\n\"nh4_c\":1.0,\n\"ptrc_c\":-2.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_06000\"\n},\n{\n\"id\":\"DCTPD\",\n\"name\":\"dCTP deaminase\",\n\"metabolites\":{\n\"dctp_c\":-1.0,\n\"dutp_c\":1.0,\n\"h2o_c\":-1.0,\n\"h_c\":-1.0,\n\"nh4_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_20305\"\n},\n{\n\"id\":\"BIOTINS\",\n\"name\":\"biotin biosynthesis hypothetical reaction\",\n\"metabolites\":{\n\"adp_c\":-1.0,\n\"atp_c\":1.0,\n\"coa_c\":1.0,\n\"h_c\":2.0,\n\"hco3_c\":1.0,\n\"malcoa_c\":-2.0,\n\"pi_c\":-1.0,\n\"pmcoa_c\":1.0\n},\n\"lower_bound\":-1000,\n\"upper_bound\":1000,\n\"gene_reaction_rule\":\"SP0001\"\n},\n{\n\"id\":\"PAPPT3\",\n\"name\":\"phospho N acetylmuramoyl pentapeptide transferase 1\",\n\"metabolites\":{\n\"uagmda_c\":1.0,\n\"udcpp_c\":-1.0,\n\"ugmda_c\":-1.0,\n\"ump_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_11215\"\n},\n{\n\"id\":\"COBALT2tex\",\n\"name\":\"Co2  transport via diffusion  extracellular to periplasm \",\n\"metabolites\":{\n\"cobalt2_e\":-1.0,\n\"cobalt2_p\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"PAPPT1\",\n\"name\":\"phospho N acetylmuramoyl pentapeptide transferase 2\",\n\"metabolites\":{\n\"uAgla_c\":-1.0,\n\"uaAgla_c\":1.0,\n\"udcpp_c\":-1.0,\n\"ump_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_11215\"\n},\n{\n\"id\":\"HISTD\",\n\"name\":\"histidinol dehydrogenase\",\n\"metabolites\":{\n\"h_c\":1.0,\n\"histd_c\":-1.0,\n\"histda_c\":1.0,\n\"nad_c\":-1.0,\n\"nadh_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_00600\"\n},\n{\n\"id\":\"DVPCLPHVR\",\n\"name\":\"3 8 divinyl protochlorophyllide 8 vinyl reductase\",\n\"metabolites\":{\n\"dvpclphd_c\":-1.0,\n\"h_c\":-1.0,\n\"mvpclphd_c\":1.0,\n\"nadp_c\":1.0,\n\"nadph_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"UQCYOR_2p\",\n\"name\":\"ubiquinol cytochrome c reductase\",\n\"metabolites\":{\n\"ficytc_c\":-2.0,\n\"focytc_c\":2.0,\n\"h_p\":2.0,\n\"q_c\":1.0,\n\"qh2_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_00050 and CQW49_00055 and CQW49_00060\"\n},\n{\n\"id\":\"EX_galcDaraba_e\",\n\"name\":\"exchange flux   3 O b D galactopyranosyl D arabinonate\",\n\"metabolites\":{\n\"galcDaraba_e\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":0.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"EX_arab_L_e\",\n\"name\":\"exchange flux   L arabinose\",\n\"metabolites\":{\n\"arab_L_e\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":0.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"ACOAD1f\",\n\"name\":\"acyl CoA dehydrogenase  n 4 0 \",\n\"metabolites\":{\n\"b2coa_c\":1.0,\n\"btcoa_c\":-1.0,\n\"fad_c\":-1.0,\n\"fadh2_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_15490 or CQW49_03065 or CQW49_11850\"\n},\n{\n\"id\":\"SULR\",\n\"name\":\"sulfite reductase  NADPH \",\n\"metabolites\":{\n\"h2o_c\":3.0,\n\"h2s_c\":1.0,\n\"h_c\":-5.0,\n\"nadp_c\":3.0,\n\"nadph_c\":-3.0,\n\"so3_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_00335\"\n},\n{\n\"id\":\"G1PACT\",\n\"name\":\"glucosamine 1 phosphate acetyltransferase\",\n\"metabolites\":{\n\"accoa_c\":-1.0,\n\"acgam1p_c\":1.0,\n\"coa_c\":1.0,\n\"gam1p_c\":-1.0,\n\"h_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_09125\"\n},\n{\n\"id\":\"DMQMT2\",\n\"name\":\"3 demethylubiquinone 8 3 O methyltransferase\",\n\"metabolites\":{\n\"ahcys_c\":1,\n\"amet_c\":-1,\n\"dmuqh2_c\":-1,\n\"h_c\":1,\n\"qh2_c\":1\n},\n\"lower_bound\":0,\n\"upper_bound\":1000,\n\"gene_reaction_rule\":\"CQW49_02235\"\n},\n{\n\"id\":\"ANS\",\n\"name\":\"anthranilate synthase\",\n\"metabolites\":{\n\"anth_c\":1.0,\n\"chor_c\":-1.0,\n\"gln_L_c\":-1.0,\n\"glu_L_c\":1.0,\n\"h_c\":1.0,\n\"pyr_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_20185 and CQW49_20270\"\n},\n{\n\"id\":\"MSUCCCOADH\",\n\"name\":\"methylsuccinyl CoA dehydrogenase\",\n\"metabolites\":{\n\"2Smsucccoa_c\":-1.0,\n\"mesaccoa_c\":1.0,\n\"oxETF_c\":-1.0,\n\"rETF_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_16350\"\n},\n{\n\"id\":\"NTPP7\",\n\"name\":\"deoxynucleoside triphosphate pyrophosphohydrolase  dTTP \",\n\"metabolites\":{\n\"dtmp_c\":1.0,\n\"dttp_c\":-1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"ppi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_11120\"\n},\n{\n\"id\":\"NIGOSH\",\n\"name\":\"nigerose hydrolase\",\n\"metabolites\":{\n\"glc_D_c\":2.0,\n\"h2o_c\":-1.0,\n\"nigos_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_10645\"\n},\n{\n\"id\":\"NTPP8\",\n\"name\":\"nucleoside triphosphate pyrophosphohydrolase  UTP \",\n\"metabolites\":{\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"ppi_c\":1.0,\n\"ump_c\":1.0,\n\"utp_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_01615 or CQW49_18780\"\n},\n{\n\"id\":\"ACOAD6f\",\n\"name\":\"acyl CoA dehydrogenase  n 14 0 \",\n\"metabolites\":{\n\"fad_c\":-1.0,\n\"fadh2_c\":1.0,\n\"td2coa_c\":1.0,\n\"tdcoa_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_15490 or CQW49_03065 or CQW49_11850\"\n},\n{\n\"id\":\"NTPP3\",\n\"name\":\"deoxynucleoside triphosphate pyrophosphohydrolase  dCTP \",\n\"metabolites\":{\n\"dcmp_c\":1.0,\n\"dctp_c\":-1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"ppi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_11120\"\n},\n{\n\"id\":\"NTPP4\",\n\"name\":\"nucleoside triphosphate pyrophosphohydrolase  CTP \",\n\"metabolites\":{\n\"cmp_c\":1.0,\n\"ctp_c\":-1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"ppi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_01615 or CQW49_11120\"\n},\n{\n\"id\":\"UAGCVT\",\n\"name\":\"UDP N acetylglucosamine 1 carboxyvinyltransferase\",\n\"metabolites\":{\n\"pep_c\":-1.0,\n\"pi_c\":1.0,\n\"uaccg_c\":1.0,\n\"uacgam_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_09360\"\n},\n{\n\"id\":\"CU2tex\",\n\"name\":\"copper transport via diffusion  extracellular to periplasm \",\n\"metabolites\":{\n\"cu2_e\":-1.0,\n\"cu2_p\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"NTPP5\",\n\"name\":\"deoxynucleoside triphosphate pyrophosphohydrolase  dATP \",\n\"metabolites\":{\n\"damp_c\":1.0,\n\"datp_c\":-1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"ppi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_11120\"\n},\n{\n\"id\":\"NTPP6\",\n\"name\":\"nucleoside triphosphate pyrophosphohydrolase  ATP \",\n\"metabolites\":{\n\"amp_c\":1.0,\n\"atp_c\":-1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"ppi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_01615 or CQW49_11120\"\n},\n{\n\"id\":\"HFACOAE120\",\n\"name\":\"acyl CoA thioesterase II  n h12 0 \",\n\"metabolites\":{\n\"R_3hddc_c\":1.0,\n\"R_3hddcoa_c\":-1.0,\n\"coa_c\":1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_00725 or CQW49_04870 or CQW49_01990\"\n},\n{\n\"id\":\"EAR121y\",\n\"name\":\"enoyl  acyl carrier protein  reductase  n 12 1 \",\n\"metabolites\":{\n\"cddec5eACP_c\":1.0,\n\"h_c\":-1.0,\n\"nadp_c\":1.0,\n\"nadph_c\":-1.0,\n\"t3c5ddeceACP_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_09320 or CQW49_16835\"\n},\n{\n\"id\":\"ALAALAr\",\n\"name\":\"D alanine D alanine ligase B\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"ala_D_c\":-2.0,\n\"alaala_c\":1.0,\n\"atp_c\":-1.0,\n\"h_c\":1.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":0,\n\"upper_bound\":1000,\n\"gene_reaction_rule\":\"CQW49_11255\"\n},\n{\n\"id\":\"FALDtex\",\n\"name\":\"formaldehyde transport via diffusion  extracellular to periplasm \",\n\"metabolites\":{\n\"fald_e\":-1.0,\n\"fald_p\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"ECOAH181\",\n\"name\":\"enoyl CoA hydratase  n 18 1 \",\n\"metabolites\":{\n\"3hcoctd11ecoa_c\":1.0,\n\"h2o_c\":-1.0,\n\"t3coctd11ecoa_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_15495 and CQW49_15500\"\n},\n{\n\"id\":\"GLYKr\",\n\"name\":\"glycerol kinase\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"glyc3p_c\":1.0,\n\"glyc_c\":-1.0,\n\"h_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_12325\"\n},\n{\n\"id\":\"EX_mn2_e\",\n\"name\":\"exchange flux   manganese\",\n\"metabolites\":{\n\"mn2_e\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"DGK1\",\n\"name\":\"deoxyguanylate kinase\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"dgdp_c\":1.0,\n\"dgmp_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_17705\"\n},\n{\n\"id\":\"ACOAD7f\",\n\"name\":\"acyl CoA dehydrogenase  n 16 0 \",\n\"metabolites\":{\n\"fad_c\":-1.0,\n\"fadh2_c\":1.0,\n\"hdd2coa_c\":1.0,\n\"pmtcoa_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_15490 or CQW49_03065 or CQW49_11850\"\n},\n{\n\"id\":\"3OAS180\",\n\"name\":\"3 oxoacyl  acyl carrier protein  synthase  n 18 0 \",\n\"metabolites\":{\n\"3ooctdACP_c\":1.0,\n\"ACP_c\":1.0,\n\"co2_c\":1.0,\n\"h_c\":-1.0,\n\"malACP_c\":-1.0,\n\"palmACP_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_17690 or CQW49_09315\"\n},\n{\n\"id\":\"3OAS181\",\n\"name\":\"3 oxoacyl  acyl carrier protein  synthase  n 18 1 \",\n\"metabolites\":{\n\"3ocvac11eACP_c\":1.0,\n\"ACP_c\":1.0,\n\"co2_c\":1.0,\n\"h_c\":-1.0,\n\"hdeACP_c\":-1.0,\n\"malACP_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_17690 or CQW49_09315\"\n},\n{\n\"id\":\"NAPRTr\",\n\"name\":\"nicotinate phosphoribosyltransferase\",\n\"metabolites\":{\n\"h_c\":1.0,\n\"nac_c\":1.0,\n\"nicrnt_c\":-1.0,\n\"ppi_c\":-1.0,\n\"prpp_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_12035\"\n},\n{\n\"id\":\"NADH11\",\n\"name\":\"NADH ubiquinone oxidoreductase I\",\n\"metabolites\":{\n\"h_c\":-5.0,\n\"h_p\":4.0,\n\"nad_c\":1.0,\n\"nadh_c\":-1.0,\n\"q_c\":-1.0,\n\"qh2_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_05325 and CQW49_05330 and CQW49_18615 and CQW49_05310 and CQW49_05315 and CQW49_05300 and CQW49_05305 and CQW49_05290 and CQW49_05335 and CQW49_05295 and CQW49_05340 and CQW49_05345 and CQW49_05285 and CQW49_05350 and CQW49_05320 and CQW49_03485\"\n},\n{\n\"id\":\"HACYLCOAEPI40\",\n\"name\":\"3 hydroxyacyl CoA epimerase  n 4 0 \",\n\"metabolites\":{\n\"3hbcoa_c\":-1.0,\n\"r3hbcoa_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_15495 and CQW49_15500\"\n},\n{\n\"id\":\"FACOAE120\",\n\"name\":\"acyl CoA thioesterase II  n 12 0 \",\n\"metabolites\":{\n\"coa_c\":1.0,\n\"ddca_c\":1.0,\n\"ddcacoa_c\":-1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_00725 or CQW49_04870 or CQW49_01990\"\n},\n{\n\"id\":\"DHAtex\",\n\"name\":\"glycerone transport via diffusion  extracellular to periplasm \",\n\"metabolites\":{\n\"dha_e\":-1.0,\n\"dha_p\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"PNTK\",\n\"name\":\"pantothenate kinase\",\n\"metabolites\":{\n\"4ppan_c\":1.0,\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"h_c\":1.0,\n\"pnto_R_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_07640\"\n},\n{\n\"id\":\"PHOTOSYS1C\",\n\"name\":\"photosystem I cyclic\",\n\"metabolites\":{\n\"fdxox_c\":2.0,\n\"fdxrd_c\":-2.0,\n\"h_c\":-2.0,\n\"q_c\":-1.0,\n\"qh2_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"OMPDC\",\n\"name\":\"orotidine 5  phosphate decarboxylase\",\n\"metabolites\":{\n\"co2_c\":1.0,\n\"h_c\":-1.0,\n\"orot5p_c\":-1.0,\n\"ump_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_20550\"\n},\n{\n\"id\":\"H2O2tex\",\n\"name\":\"H2O2 transport via diffusion  extracellular to periplasm \",\n\"metabolites\":{\n\"h2o2_e\":-1.0,\n\"h2o2_p\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"SERTRS\",\n\"name\":\"serine tRNA synthetase\",\n\"metabolites\":{\n\"amp_c\":1.0,\n\"atp_c\":-1.0,\n\"ppi_c\":1.0,\n\"ser_L_c\":-1.0,\n\"sertrna_c\":1.0,\n\"trnaser_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_02195\"\n},\n{\n\"id\":\"Kt3pp\",\n\"name\":\"potassium proton antiporter\",\n\"metabolites\":{\n\"h_c\":1.0,\n\"h_p\":-1.0,\n\"k_c\":-1.0,\n\"k_p\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_09385\"\n},\n{\n\"id\":\"ACOAD4f\",\n\"name\":\"acyl CoA dehydrogenase  n 10 0 \",\n\"metabolites\":{\n\"dc2coa_c\":1.0,\n\"dcacoa_c\":-1.0,\n\"fad_c\":-1.0,\n\"fadh2_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_15490 or CQW49_03065 or CQW49_11850\"\n},\n{\n\"id\":\"CO2DAMR\",\n\"name\":\"cob II yrinate a c diamide reductase\",\n\"metabolites\":{\n\"co1dam_c\":1.0,\n\"co2dam_c\":-1.0,\n\"fmn_c\":1.0,\n\"fmnh2_c\":-1.0,\n\"h_c\":2.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_01800\"\n},\n{\n\"id\":\"AMMQT8_2\",\n\"name\":\" S  adenosylmethionine 2 DMK methyltransferase\",\n\"metabolites\":{\n\"2dmmq8_c\":-1.0,\n\"ahcys_c\":1.0,\n\"amet_c\":-1.0,\n\"h_c\":1.0,\n\"mqn8_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_18430\"\n},\n{\n\"id\":\"CO2DAMS\",\n\"name\":\"cobyrinic acid a c diamide synthase\",\n\"metabolites\":{\n\"adp_c\":2.0,\n\"atp_c\":-2.0,\n\"co2dam_c\":1.0,\n\"cobya_c\":-1.0,\n\"gln_L_c\":-2.0,\n\"glu_L_c\":2.0,\n\"h2o_c\":-2.0,\n\"h_c\":2.0,\n\"pi_c\":2.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_09625\"\n},\n{\n\"id\":\"CYOD\",\n\"name\":\"cytochrome bd ubiquinol oxidase\",\n\"metabolites\":{\n\"h2o_c\":2.0,\n\"h_c\":-4.0,\n\"h_p\":4.0,\n\"o2_c\":-1.0,\n\"q_c\":2.0,\n\"qh2_c\":-2.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_11625 and CQW49_11630\"\n},\n{\n\"id\":\"EX_glu_L_e\",\n\"name\":\"exchange flux   L glutamate\",\n\"metabolites\":{\n\"glu_L_e\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":0.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"HFACOAE100\",\n\"name\":\"acyl CoA thioesterase II  n h10 0 \",\n\"metabolites\":{\n\"R_3hdc_c\":1.0,\n\"R_3hdcoa_c\":-1.0,\n\"coa_c\":1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_00725 or CQW49_04870 or CQW49_01990\"\n},\n{\n\"id\":\"EX_DM_oxEA\",\n\"name\":\"exchange flux   oxidized electron acceptor\",\n\"metabolites\":{\n\"oxEA_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"GRTT\",\n\"name\":\"farnesyl diphosphate synthase\",\n\"metabolites\":{\n\"frdp_c\":1.0,\n\"grdp_c\":-1.0,\n\"ipdp_c\":-1.0,\n\"ppi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_16515\"\n},\n{\n\"id\":\"THDPS\",\n\"name\":\"2 3 4 5 tetrahydropyridine 2 carboxylate N succinyltransferase\",\n\"metabolites\":{\n\"coa_c\":1.0,\n\"h2o_c\":-1.0,\n\"sl2a6o_c\":1.0,\n\"succoa_c\":-1.0,\n\"thdp_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_16565\"\n},\n{\n\"id\":\"PRPPS\",\n\"name\":\"phosphoribosylpyrophosphate synthetase\",\n\"metabolites\":{\n\"amp_c\":1.0,\n\"atp_c\":-1.0,\n\"h_c\":1.0,\n\"prpp_c\":1.0,\n\"r5p_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_06925\"\n},\n{\n\"id\":\"EAR180y\",\n\"name\":\"enoyl  acyl carrier protein  reductase  n 18 0 \",\n\"metabolites\":{\n\"h_c\":-1.0,\n\"nadp_c\":1.0,\n\"nadph_c\":-1.0,\n\"ocdcaACP_c\":1.0,\n\"toctd2eACP_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_09320 or CQW49_16835\"\n},\n{\n\"id\":\"DAPDC\",\n\"name\":\"diaminopimelate decarboxylase\",\n\"metabolites\":{\n\"26dap_M_c\":-1.0,\n\"co2_c\":1.0,\n\"h_c\":-1.0,\n\"lys_L_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_10715\"\n},\n{\n\"id\":\"CREAH\",\n\"name\":\"creatininase\",\n\"metabolites\":{\n\"creat_c\":1.0,\n\"crtn_c\":-1.0,\n\"h2o_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_06535\"\n},\n{\n\"id\":\"EX_zn2_e\",\n\"name\":\"exchange flux   zinc\",\n\"metabolites\":{\n\"zn2_e\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"A5PISO\",\n\"name\":\"D arabinose 5 phosphate isomerase\",\n\"metabolites\":{\n\"ara5p_c\":-1.0,\n\"ru5p_D_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"META1_3866\"\n},\n{\n\"id\":\"KAS14\",\n\"name\":\"3 oxoacyl  acyl carrier protein  synthase  n 4 0 \",\n\"metabolites\":{\n\"ACP_c\":1.0,\n\"acACP_c\":-1.0,\n\"actACP_c\":1.0,\n\"co2_c\":1.0,\n\"h_c\":-1.0,\n\"malACP_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_03730 or CQW49_17690 or CQW49_09315\"\n},\n{\n\"id\":\"SHCHF\",\n\"name\":\"sirohydrochlorin ferrochelatase\",\n\"metabolites\":{\n\"fe2_c\":-1.0,\n\"h_c\":3.0,\n\"scl_c\":-1.0,\n\"sheme_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_21195\"\n},\n{\n\"id\":\"ACOAD5f\",\n\"name\":\"acyl CoA dehydrogenase  n 12 0 \",\n\"metabolites\":{\n\"dd2coa_c\":1.0,\n\"ddcacoa_c\":-1.0,\n\"fad_c\":-1.0,\n\"fadh2_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_15490 or CQW49_03065 or CQW49_11850\"\n},\n{\n\"id\":\"CS\",\n\"name\":\"citrate synthase\",\n\"metabolites\":{\n\"accoa_c\":-1.0,\n\"cit_c\":1.0,\n\"coa_c\":1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"oaa_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_04750\"\n},\n{\n\"id\":\"MDH\",\n\"name\":\"malate dehydrogenase\",\n\"metabolites\":{\n\"h_c\":1.0,\n\"mal_L_c\":-1.0,\n\"nad_c\":-1.0,\n\"nadh_c\":1.0,\n\"oaa_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_18955\"\n},\n{\n\"id\":\"PROTRS\",\n\"name\":\"proline tRNA ligase\",\n\"metabolites\":{\n\"amp_c\":1.0,\n\"atp_c\":-1.0,\n\"ppi_c\":1.0,\n\"pro_L_c\":-1.0,\n\"protrna_c\":1.0,\n\"trnapro_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_16645\"\n},\n{\n\"id\":\"BPNT\",\n\"name\":\"adenosine 3  2   5  bisphosphate nucleotidase\",\n\"metabolites\":{\n\"amp_c\":1.0,\n\"h2o_c\":-1.0,\n\"pap_c\":-1.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_04630\"\n},\n{\n\"id\":\"HACYLCOAEPI60\",\n\"name\":\"3 hydroxyacyl CoA epimerase  n 6 0 \",\n\"metabolites\":{\n\"3hhcoa_c\":-1.0,\n\"R_3hhcoa_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_15495 and CQW49_15500\"\n},\n{\n\"id\":\"3OAS60\",\n\"name\":\"3 oxoacyl  acyl carrier protein  synthase  n 6 0 \",\n\"metabolites\":{\n\"3ohexACP_c\":1.0,\n\"ACP_c\":1.0,\n\"butACP_c\":-1.0,\n\"co2_c\":1.0,\n\"h_c\":-1.0,\n\"malACP_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_03730 or CQW49_17690 or CQW49_09315\"\n},\n{\n\"id\":\"ECOAH161\",\n\"name\":\"enoyl CoA hydratase  n 16 1 \",\n\"metabolites\":{\n\"3hchd9ecoa_c\":1.0,\n\"h2o_c\":-1.0,\n\"t3chd9ecoa_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_15495 and CQW49_15500\"\n},\n{\n\"id\":\"FACOAE100\",\n\"name\":\"acyl CoA thioesterase II  n 10 0 \",\n\"metabolites\":{\n\"coa_c\":1.0,\n\"dca_c\":1.0,\n\"dcacoa_c\":-1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_00725 or CQW49_04870 or CQW49_01990\"\n},\n{\n\"id\":\"NFORGLUAH\",\n\"name\":\"N formylglutamate amidohydrolase\",\n\"metabolites\":{\n\"Nforglu_c\":-1.0,\n\"for_c\":1.0,\n\"glu_L_c\":1.0,\n\"h2o_c\":-1.0,\n\"h_c\":2.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_00950\"\n},\n{\n\"id\":\"TDPDRR\",\n\"name\":\"dTDP 4 dehydrorhamnose reductase\",\n\"metabolites\":{\n\"dtdp4d6dm_c\":-1.0,\n\"dtdprmn_c\":1.0,\n\"h_c\":-1.0,\n\"nadp_c\":1.0,\n\"nadph_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_06235\"\n},\n{\n\"id\":\"EX_mal_L_e\",\n\"name\":\"exchange flux    S  malate\",\n\"metabolites\":{\n\"mal_L_e\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":0.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"HFACOAE160\",\n\"name\":\"acyl CoA thioesterase II  n h16 0 \",\n\"metabolites\":{\n\"R_3hhdc_c\":1.0,\n\"R_3hhdccoa_c\":-1.0,\n\"coa_c\":1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_00725 or CQW49_04870 or CQW49_01990\"\n},\n{\n\"id\":\"ACACtex\",\n\"name\":\"acetoacetate transport via diffusion  extracellular to periplasm \",\n\"metabolites\":{\n\"acac_e\":-1.0,\n\"acac_p\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"TDPDRE\",\n\"name\":\"dTDP 4 dehydrorhamnose 3 5 epimerase\",\n\"metabolites\":{\n\"dtdp4d6dg_c\":-1.0,\n\"dtdp4d6dm_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_06240\"\n},\n{\n\"id\":\"ARBtex\",\n\"name\":\"L arabinose transport via diffusion  extracellular to periplasm \",\n\"metabolites\":{\n\"arab_L_e\":-1.0,\n\"arab_L_p\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"MTHFR3\",\n\"name\":\"5 10 methylenetetrahydrofolate reductase\",\n\"metabolites\":{\n\"5mthf_c\":1.0,\n\"h_c\":-2.0,\n\"mlthf_c\":-1.0,\n\"nadp_c\":1.0,\n\"nadph_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_19060\"\n},\n{\n\"id\":\"OMCDC\",\n\"name\":\"2 isopropyl 3 oxosuccinate decarboxylase\",\n\"metabolites\":{\n\"3c4mop_c\":-1.0,\n\"4mop_c\":1.0,\n\"co2_c\":1.0,\n\"h_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"SP0001\"\n},\n{\n\"id\":\"EX_cit_e\",\n\"name\":\"exchange flux   citrate\",\n\"metabolites\":{\n\"cit_e\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":0.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"DPGM\",\n\"name\":\"bisphosphoglycerate mutase\",\n\"metabolites\":{\n\"13dpg_c\":-1.0,\n\"23dpg_c\":1.0,\n\"h_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_04780 or CQW49_21215\"\n},\n{\n\"id\":\"GLYD\",\n\"name\":\"hydroxypyruvate reductase\",\n\"metabolites\":{\n\"glyc_R_c\":1.0,\n\"h_c\":-1.0,\n\"hpyr_c\":-1.0,\n\"nad_c\":1.0,\n\"nadh_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_10845 or CQW49_06750 or CQW49_12205\"\n},\n{\n\"id\":\"O2tpp\",\n\"name\":\"O2 transport via diffusion  periplasm to cytoplasm \",\n\"metabolites\":{\n\"o2_c\":1.0,\n\"o2_p\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"MEOHtex\",\n\"name\":\"methanol transport via diffusion  extracellular to periplasm \",\n\"metabolites\":{\n\"meoh_e\":-1.0,\n\"meoh_p\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"ACCOACr\",\n\"name\":\"acetyl CoA carboxylase\",\n\"metabolites\":{\n\"accoa_c\":-1.0,\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"h_c\":1.0,\n\"hco3_c\":-1.0,\n\"malcoa_c\":1.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_05020 and CQW49_05015 and CQW49_15425 and CQW49_04275\"\n},\n{\n\"id\":\"EX_glcn_e\",\n\"name\":\"exchange flux   D gluconate\",\n\"metabolites\":{\n\"glcn_e\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":0.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"DHAD2\",\n\"name\":\"2 3 dihydroxy 3 methylvalerate dehydratase\",\n\"metabolites\":{\n\"23dhmp_c\":-1.0,\n\"3mop_c\":1.0,\n\"h2o_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_03905\"\n},\n{\n\"id\":\"GLYOX\",\n\"name\":\"S lactoylglutathione hydrolase\",\n\"metabolites\":{\n\"gthrd_c\":1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"lac_D_c\":1.0,\n\"lgt_S_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_21005\"\n},\n{\n\"id\":\"DHAD1\",\n\"name\":\"2 3 dihydroxy isovalerate dehydratase\",\n\"metabolites\":{\n\"23dhmb_c\":-1.0,\n\"3mob_c\":1.0,\n\"h2o_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_03905\"\n},\n{\n\"id\":\"DASYN160\",\n\"name\":\"CDP diacylglycerol synthetase  n 16 0 \",\n\"metabolites\":{\n\"cdpdhdecg_c\":1.0,\n\"ctp_c\":-1.0,\n\"h_c\":-1.0,\n\"pa160_c\":-1.0,\n\"ppi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_00450\"\n},\n{\n\"id\":\"3OAS140\",\n\"name\":\"3 oxoacyl  acyl carrier protein  synthase  n 14 0 \",\n\"metabolites\":{\n\"3omrsACP_c\":1.0,\n\"ACP_c\":1.0,\n\"co2_c\":1.0,\n\"ddcaACP_c\":-1.0,\n\"h_c\":-1.0,\n\"malACP_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_03730 or CQW49_17690 or CQW49_09315\"\n},\n{\n\"id\":\"BTS6\",\n\"name\":\"biotin synthase\",\n\"metabolites\":{\n\"Ssact_c\":-1.0,\n\"amet_c\":-2.0,\n\"btn_c\":1.0,\n\"dad_2_c\":2.0,\n\"dtbt_c\":-1.0,\n\"h_c\":2.0,\n\"met_L_c\":2.0,\n\"uSsact_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_05065\"\n},\n{\n\"id\":\"3OAS141\",\n\"name\":\"3 oxoacyl  acyl carrier protein  synthase  n 14 1 \",\n\"metabolites\":{\n\"3ocmrs7eACP_c\":1.0,\n\"ACP_c\":1.0,\n\"cddec5eACP_c\":-1.0,\n\"co2_c\":1.0,\n\"h_c\":-1.0,\n\"malACP_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_03730 or CQW49_17690 or CQW49_09315\"\n},\n{\n\"id\":\"DASYN161\",\n\"name\":\"CDP diacylglycerol synthetase  n 16 1 \",\n\"metabolites\":{\n\"cdpdhdec9eg_c\":1.0,\n\"ctp_c\":-1.0,\n\"h_c\":-1.0,\n\"pa161_c\":-1.0,\n\"ppi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_00450\"\n},\n{\n\"id\":\"NH4tex\",\n\"name\":\"NH3 transport via diffusion  extracellular to periplasm \",\n\"metabolites\":{\n\"nh4_e\":-1.0,\n\"nh4_p\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"MALCOAL\",\n\"name\":\"malyl CoA lyase\",\n\"metabolites\":{\n\"accoaa_c\":1,\n\"glx_c\":1,\n\"malScoa_c\":-1\n},\n\"lower_bound\":-1000,\n\"upper_bound\":1000,\n\"gene_reaction_rule\":\"CQW49_12235\"\n},\n{\n\"id\":\"ECOAH141\",\n\"name\":\"enoyl CoA hydratase  n 14 1 \",\n\"metabolites\":{\n\"3hctd7ecoa_c\":1.0,\n\"h2o_c\":-1.0,\n\"t3ctd7ecoa_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_15495 and CQW49_15500\"\n},\n{\n\"id\":\"SULFOX2\",\n\"name\":\"sulfite oxidase\",\n\"metabolites\":{\n\"h2o2_c\":1.0,\n\"h2o_c\":-1.0,\n\"o2_c\":-1.0,\n\"so3_c\":-1.0,\n\"so4_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_11645\"\n},\n{\n\"id\":\"3OAS80\",\n\"name\":\"3 oxoacyl  acyl carrier protein  synthase  n 8 0 \",\n\"metabolites\":{\n\"3ooctACP_c\":1.0,\n\"ACP_c\":1.0,\n\"co2_c\":1.0,\n\"h_c\":-1.0,\n\"hexACP_c\":-1.0,\n\"malACP_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_03730 or CQW49_17690 or CQW49_09315\"\n},\n{\n\"id\":\"EX_tartr_L_e\",\n\"name\":\"exchange flux   L tartrate\",\n\"metabolites\":{\n\"tartr_L_e\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":0.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"MALCOAS\",\n\"name\":\"malyl CoA synthetase\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"coa_c\":-1.0,\n\"malScoa_c\":1.0,\n\"mal_L_c\":-1.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_12225 and CQW49_12220\"\n},\n{\n\"id\":\"EX_2driboa_e\",\n\"name\":\"exchange flux   2 deoxy D ribonate\",\n\"metabolites\":{\n\"2driboa_e\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":0.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"OCTDPS2\",\n\"name\":\"octaprenyl diphosphate synthase 4\",\n\"metabolites\":{\n\"hepdp_c\":-1.0,\n\"ipdp_c\":-1.0,\n\"octdp_c\":1.0,\n\"ppi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_18820\"\n},\n{\n\"id\":\"PRAGSr\",\n\"name\":\"phosphoribosylglycinamide synthetase\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"gar_c\":1.0,\n\"gly_c\":-1.0,\n\"h_c\":1.0,\n\"pi_c\":1.0,\n\"pram_c\":-1.0\n},\n\"lower_bound\":0,\n\"upper_bound\":1000,\n\"gene_reaction_rule\":\"CQW49_04980\"\n},\n{\n\"id\":\"MPTSS\",\n\"name\":\"molybdopterin synthase sulfurylase\",\n\"metabolites\":{\n\"mptS_c\":2.0,\n\"mptSs_c\":-2.0,\n\"mpt_c\":1.0,\n\"precZ_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_16065 or (CQW49_03700 and CQW49_03705)\"\n},\n{\n\"id\":\"MPTSP\",\n\"name\":\"molybderin biosynthesis protein\",\n\"metabolites\":{\n\"gtp_c\":-1.0,\n\"h2o_c\":-1.0,\n\"h_c\":2.0,\n\"ppi_c\":1.0,\n\"precZ_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_12160 and META1_0772\"\n},\n{\n\"id\":\"HFACOAE140\",\n\"name\":\"acyl CoA thioesterase II  n h14 0 \",\n\"metabolites\":{\n\"R_3hmrscoa_c\":-1.0,\n\"R_3htdc_c\":1.0,\n\"coa_c\":1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_00725 or CQW49_04870 or CQW49_01990\"\n},\n{\n\"id\":\"UDPGCGT\",\n\"name\":\"ceramide glucosyltransferase\",\n\"metabolites\":{\n\"crm_c\":-1.0,\n\"glccrm_c\":1.0,\n\"h_c\":1.0,\n\"udp_c\":1.0,\n\"udpg_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_09025\"\n},\n{\n\"id\":\"EX_DM_trnaser\",\n\"name\":\"exchange flux   tRNA Ser \",\n\"metabolites\":{\n\"trnaser_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"UAGPT3\",\n\"name\":\"UDP N acetylglucosamine  N acetylmuramyl  pentapeptide  pyrophosphoryl undecaprenol N acetylglucosamine transferase 2\",\n\"metabolites\":{\n\"h_c\":1.0,\n\"uaagmda_c\":1.0,\n\"uacgam_c\":-1.0,\n\"uagmda_c\":-1.0,\n\"udp_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_11230\"\n},\n{\n\"id\":\"FT\",\n\"name\":\"undecaprenyl diphosphate synthase 1\",\n\"metabolites\":{\n\"frdp_c\":-1.0,\n\"ipdp_c\":-1.0,\n\"ppi_c\":1.0,\n\"ttc_ggdp_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_00445\"\n},\n{\n\"id\":\"ACOAD8f\",\n\"name\":\"acyl CoA dehydrogenase  n 18 0 \",\n\"metabolites\":{\n\"fad_c\":-1.0,\n\"fadh2_c\":1.0,\n\"od2coa_c\":1.0,\n\"stcoa_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_15490 or CQW49_03065 or CQW49_11850\"\n},\n{\n\"id\":\"EX_cobalt2_e\",\n\"name\":\"exchange flux   Co2 \",\n\"metabolites\":{\n\"cobalt2_e\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"LPADSS\",\n\"name\":\"lipid A disaccharide synthase\",\n\"metabolites\":{\n\"h_c\":1.0,\n\"lipidAds_c\":1.0,\n\"lipidX_c\":-1.0,\n\"u23ga_c\":-1.0,\n\"udp_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_00485\"\n},\n{\n\"id\":\"GLYO1\",\n\"name\":\"glycine oxidase 1\",\n\"metabolites\":{\n\"glx_c\":1.0,\n\"gly_c\":-1.0,\n\"h2o2_c\":1.0,\n\"h2o_c\":-1.0,\n\"nh4_c\":1.0,\n\"o2_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_14270\"\n},\n{\n\"id\":\"DHDPS\",\n\"name\":\"dihydrodipicolinate synthase\",\n\"metabolites\":{\n\"23dhdp_c\":1.0,\n\"aspsa_c\":-1.0,\n\"h2o_c\":2.0,\n\"h_c\":1.0,\n\"pyr_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_15395 or CQW49_13400\"\n},\n{\n\"id\":\"GLCNtex\",\n\"name\":\"D gluconate transport via diffusion  extracellular to periplasm \",\n\"metabolites\":{\n\"glcn_e\":-1.0,\n\"glcn_p\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"GLUR\",\n\"name\":\"glutamate racemase\",\n\"metabolites\":{\n\"glu_D_c\":1.0,\n\"glu_L_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_11180\"\n},\n{\n\"id\":\"GK1\",\n\"name\":\"guanylate kinase\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"gdp_c\":1.0,\n\"gmp_c\":-1.0\n},\n\"lower_bound\":0,\n\"upper_bound\":1000,\n\"gene_reaction_rule\":\"CQW49_17705\"\n},\n{\n\"id\":\"MCOATA\",\n\"name\":\"malonyl CoA  acyl carrier protein  transacylase\",\n\"metabolites\":{\n\"ACP_c\":-1.0,\n\"coa_c\":1.0,\n\"malACP_c\":1.0,\n\"malcoa_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_11930 or CQW49_17670\"\n},\n{\n\"id\":\"CELLS\",\n\"name\":\"cellulose synthase\",\n\"metabolites\":{\n\"14bglu_c\":0.1,\n\"udp_c\":1.0,\n\"udpg_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"META1_0940 or META1_0898 or META1_1167\"\n},\n{\n\"id\":\"EX_mma_e\",\n\"name\":\"exchange flux   methylamine\",\n\"metabolites\":{\n\"mma_e\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":0.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"EAR120y\",\n\"name\":\"enoyl  acyl carrier protein  reductase  n 12 0 \",\n\"metabolites\":{\n\"ddcaACP_c\":1.0,\n\"h_c\":-1.0,\n\"nadp_c\":1.0,\n\"nadph_c\":-1.0,\n\"tddec2eACP_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_09320 or CQW49_16835\"\n},\n{\n\"id\":\"ASPTRS_tASN\",\n\"name\":\"nondiscriminating aspartate tRNA synthetase\",\n\"metabolites\":{\n\"amp_c\":1.0,\n\"asp_L_c\":-1.0,\n\"asptrna_asn_c\":1.0,\n\"atp_c\":-1.0,\n\"ppi_c\":1.0,\n\"trnaasn_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_19795\"\n},\n{\n\"id\":\"SDACT\",\n\"name\":\"sulfur donor activation\",\n\"metabolites\":{\n\"Ssact_c\":1.0,\n\"h2s_c\":-1.0,\n\"uSsact_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"SPMDAT1\",\n\"name\":\"spermidine acetyltransferase\",\n\"metabolites\":{\n\"N1aspmd_c\":1.0,\n\"accoa_c\":-1.0,\n\"coa_c\":1.0,\n\"h_c\":1.0,\n\"spmd_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_06915\"\n},\n{\n\"id\":\"SUCCtex\",\n\"name\":\"succinate transport via diffusion  extracellular to periplasm \",\n\"metabolites\":{\n\"succ_e\":-1.0,\n\"succ_p\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"EX_DM_trnamet\",\n\"name\":\"exchange flux   tRNA Met \",\n\"metabolites\":{\n\"trnamet_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"OHPBAT\",\n\"name\":\"phosphohydroxythreonine aminotransferase\",\n\"metabolites\":{\n\"akg_c\":1.0,\n\"glu_L_c\":-1.0,\n\"ohpb_c\":-1.0,\n\"phthr_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_10840\"\n},\n{\n\"id\":\"DASYN180\",\n\"name\":\"CDP diacylglycerol synthetase  n 18 0 \",\n\"metabolites\":{\n\"cdpdodecg_c\":1.0,\n\"ctp_c\":-1.0,\n\"h_c\":-1.0,\n\"pa180_c\":-1.0,\n\"ppi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_00450\"\n},\n{\n\"id\":\"ZNabcpp\",\n\"name\":\"zinc ABC transporter\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"pi_c\":1.0,\n\"zn2_c\":1.0,\n\"zn2_p\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"NTPP1\",\n\"name\":\"deoxynucleoside triphosphate pyrophosphohydrolase  dGTP \",\n\"metabolites\":{\n\"dgmp_c\":1.0,\n\"dgtp_c\":-1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"ppi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_11120\"\n},\n{\n\"id\":\"NTPP2\",\n\"name\":\"nucleoside triphosphate pyrophosphohydrolase  GTP \",\n\"metabolites\":{\n\"gmp_c\":1.0,\n\"gtp_c\":-1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"ppi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_01615 or CQW49_11120\"\n},\n{\n\"id\":\"DASYN181\",\n\"name\":\"CDP diacylglycerol synthetase  n 18 1 \",\n\"metabolites\":{\n\"cdpdodec11eg_c\":1.0,\n\"ctp_c\":-1.0,\n\"h_c\":-1.0,\n\"pa181_c\":-1.0,\n\"ppi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_00450\"\n},\n{\n\"id\":\"GALCDARABAtex\",\n\"name\":\"3 O b D galactopyranosyl D arabinonate transport via diffusion  extracellular to periplasm \",\n\"metabolites\":{\n\"galcDaraba_e\":-1.0,\n\"galcDaraba_p\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"RBFSa\",\n\"name\":\"6 7 dimethyl 8 ribityllumazine synthase\",\n\"metabolites\":{\n\"4r5au_c\":-1.0,\n\"db4p_c\":-1.0,\n\"dmlz_c\":1.0,\n\"h2o_c\":2.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_19510 and CQW49_19515\"\n},\n{\n\"id\":\"3OAS160\",\n\"name\":\"3 oxoacyl  acyl carrier protein  synthase  n 16 0 \",\n\"metabolites\":{\n\"3opalmACP_c\":1.0,\n\"ACP_c\":1.0,\n\"co2_c\":1.0,\n\"h_c\":-1.0,\n\"malACP_c\":-1.0,\n\"myrsACP_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_03730 or CQW49_17690 or CQW49_09315\"\n},\n{\n\"id\":\"3OAS161\",\n\"name\":\"3 oxoacyl  acyl carrier protein  synthase  n 16 1 \",\n\"metabolites\":{\n\"3ocpalm9eACP_c\":1.0,\n\"ACP_c\":1.0,\n\"co2_c\":1.0,\n\"h_c\":-1.0,\n\"malACP_c\":-1.0,\n\"tdeACP_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_03730 or CQW49_17690 or CQW49_09315\"\n},\n{\n\"id\":\"EAR100y\",\n\"name\":\"enoyl  acyl carrier protein  reductase  n 10 0 \",\n\"metabolites\":{\n\"dcaACP_c\":1.0,\n\"h_c\":-1.0,\n\"nadp_c\":1.0,\n\"nadph_c\":-1.0,\n\"tdec2eACP_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_09320 or CQW49_16835\"\n},\n{\n\"id\":\"RBFSb\",\n\"name\":\"riboflavin synthase\",\n\"metabolites\":{\n\"4r5au_c\":1.0,\n\"dmlz_c\":-2.0,\n\"ribflv_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_19510 and CQW49_19515\"\n},\n{\n\"id\":\"ECOAH121\",\n\"name\":\"enoyl CoA hydratase  n 12 1 \",\n\"metabolites\":{\n\"3hcdd5ecoa_c\":1.0,\n\"h2o_c\":-1.0,\n\"t3cdd5ecoa_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_15495 and CQW49_15500\"\n},\n{\n\"id\":\"DADK\",\n\"name\":\"adenylate kinase 2\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"dadp_c\":1.0,\n\"damp_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_10390\"\n},\n{\n\"id\":\"Biomass_Mextorquens_AM1_core\",\n\"name\":\"Methylobacterium extorquens strain AM1 core biomass equation\",\n\"metabolites\":{\n\"14bglu_c\":-0.034671,\n\"acgam_c\":-0.033189,\n\"adocbl_c\":-0.0002196,\n\"adp_c\":53.6983295,\n\"alatrna_c\":-1.1034,\n\"amet_c\":-0.0002196,\n\"amp_c\":-0.00078936,\n\"argtrna_c\":-0.24101,\n\"asntrna_c\":-0.24971,\n\"asptrna_c\":-0.24779,\n\"atp_c\":-53.82276,\n\"btn_c\":-0.0002196,\n\"ca2_c\":-0.00495,\n\"cl_c\":-0.00495,\n\"coa_c\":-0.0002196,\n\"ctp_c\":-0.086994,\n\"cu2_c\":-0.0033,\n\"cystrna_c\":-0.00097594,\n\"datp_c\":-0.015288,\n\"dctp_c\":-0.033249,\n\"dgtp_c\":-0.033249,\n\"dpundcpGlcNacMurNacpentpept_c\":-0.0001,\n\"dtpcudcpp_c\":-6.036e-05,\n\"dttp_c\":-0.015288,\n\"fad_c\":-0.0002196,\n\"fe2_c\":-0.00737,\n\"fmn_c\":-0.0002196,\n\"glntrna_c\":-0.2774,\n\"glutrna_c\":-0.27528,\n\"glytrna_c\":-1.1725,\n\"gthrd_c\":-0.0002196,\n\"gtp_c\":-0.086994,\n\"h2o_c\":-53.70035,\n\"h4mpt_c\":-0.00033,\n\"h_c\":53.6983295,\n\"hemeD_c\":-0.0002196,\n\"hemeO_c\":-0.0002196,\n\"histrna_c\":-0.067763,\n\"iletrna_c\":-0.20857,\n\"k_c\":-0.18447,\n\"kdo2lipid4L_c\":-0.0001,\n\"leutrna_c\":-0.39695,\n\"lystrna_c\":-0.25754,\n\"mettrna_c\":-0.056309,\n\"mg2_c\":-0.00825,\n\"mn2_c\":-0.0033,\n\"mobd_c\":-0.0033,\n\"mocogdp_c\":-0.0002196,\n\"na1_c\":-0.00407,\n\"nad_c\":-0.0027535,\n\"nadh_c\":-0.0016711,\n\"nadp_c\":-0.00093984,\n\"nadph_c\":-0.0015022,\n\"nh4_c\":-0.01232,\n\"pbhb_c\":-0.27738,\n\"pe160_c\":-0.0022561,\n\"pe161_c\":-0.002274,\n\"pe180_c\":-0.0021774,\n\"pe181_c\":-0.035412,\n\"pg160_c\":-0.00099536,\n\"pg161_c\":-0.0010032,\n\"pg180_c\":-0.00096064,\n\"pg181_c\":-0.015623,\n\"phetrna_c\":-0.13596,\n\"pi_c\":53.69607,\n\"ppi_c\":0.345915,\n\"protrna_c\":-0.31084,\n\"ps160_c\":-6.6355e-05,\n\"ps161_c\":-6.6898e-05,\n\"ps180_c\":-6.4038e-05,\n\"ps181_c\":-0.0010415,\n\"ptrc_c\":-0.045376,\n\"pydx5p_c\":-0.0002196,\n\"qh2_c\":-0.0002196,\n\"rmn_c\":-0.61021,\n\"sertrna_c\":-0.3101,\n\"sheme_c\":-0.0002196,\n\"so4_c\":-0.00407,\n\"splxanth_c\":-0.0003864,\n\"thf_c\":-8.184e-05,\n\"thmpp_c\":-0.0002196,\n\"thrtrna_c\":-0.30765,\n\"tre_c\":-0.035522,\n\"trptrna_c\":-0.00060401,\n\"tyrtrna_c\":-0.075485,\n\"utp_c\":-0.040008,\n\"valtrna_c\":-0.42003,\n\"zn2_c\":-0.0033\n},\n\"lower_bound\":0,\n\"upper_bound\":1000,\n\"gene_reaction_rule\":\"\",\n\"objective_coefficient\":1.0\n},\n{\n\"id\":\"EX_ch4_e\",\n\"name\":\"methane exchange\",\n\"metabolites\":{\n\"ch4_e\":-1.0\n},\n\"lower_bound\":-14.9,\n\"upper_bound\":0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"CH4tex\",\n\"name\":\"methane transport via diffusion (extracellular to periplasm)\",\n\"metabolites\":{\n\"ch4_e\":-1.0,\n\"ch4_p\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"PMMOipp\",\n\"name\":\"particulate Methane Monooxygenase\",\n\"metabolites\":{\n\"ch4_p\":-1,\n\"h2o_p\":1,\n\"meoh_p\":1,\n\"o2_p\":-1,\n\"q_c\":1,\n\"qh2_c\":-1\n},\n\"lower_bound\":0,\n\"upper_bound\":1000,\n\"gene_reaction_rule\":\"CQW49_10250 and (CQW49_10255 or CQW49_01220) and CQW49_10260\"\n},\n{\n\"id\":\"PMMODCipp\",\n\"name\":\"particulate Methane Monooxygenase - Direct Coupling\",\n\"metabolites\":{\n\"ch4_p\":-1,\n\"ficytc_c\":2.0,\n\"focytc_c\":-2.0,\n\"h2o_p\":1,\n\"h_p\":-2.0,\n\"meoh_p\":1,\n\"o2_p\":-1\n},\n\"lower_bound\":0,\n\"upper_bound\":0,\n\"gene_reaction_rule\":\"CQW49_10250 and (CQW49_10255 or CQW49_01220) and CQW49_10260\"\n},\n{\n\"id\":\"ALDD1\",\n\"name\":\"ALDD1\",\n\"metabolites\":{\n\"fald_c\":-1.0,\n\"for_c\":1.0,\n\"h2o_c\":-1.0,\n\"h_c\":2.0,\n\"nad_c\":-1.0,\n\"nadh_c\":1.0\n},\n\"lower_bound\":0,\n\"upper_bound\":0,\n\"gene_reaction_rule\":\"CQW49_21075\"\n},\n{\n\"id\":\"N2trpp\",\n\"name\":\"Nitrogen exchange, diffusion (periplasm)\",\n\"metabolites\":{\n\"n2_c\":1.0,\n\"n2_p\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"N2tex\",\n\"name\":\"Nitrogen exchange, diffusion (extra-organism to periplasm)\",\n\"metabolites\":{\n\"n2_e\":-1.0,\n\"n2_p\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"EX_n2_e\",\n\"name\":\"N2 exchange\",\n\"metabolites\":{\n\"n2_e\":-1.0\n},\n\"lower_bound\":0,\n\"upper_bound\":0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"EX_no2_e\",\n\"name\":\"nitrite exchange\",\n\"metabolites\":{\n\"no2_e\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"NO2tex\",\n\"name\":\"nitrite transport via diffusion (extracellular to periplasm)\",\n\"metabolites\":{\n\"no2_e\":-1.0,\n\"no2_p\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"SAMMOi\",\n\"name\":\"soluble ammonia monooxygenase\",\n\"metabolites\":{\n\"h2o_c\":1.0,\n\"ham_c\":1.0,\n\"nad_c\":1.0,\n\"nadh_c\":-1.0,\n\"nh4_c\":-1.0,\n\"o2_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_12480 and CQW49_12475 and CQW49_12465 and CQW49_12470 and CQW49_12455 and CQW49_12485 and CQW49_12495\",\n\"notes\":{\n\"EC Number\":\"sigma-54 dependent transcriptional regulator, acetoin dehydrogenase operon transcriptional activator AcoR\"\n}\n},\n{\n\"id\":\"NO3t7pp\",\n\"name\":\"Nitrate transport in via nitrite antiport (periplasm)\",\n\"metabolites\":{\n\"no2_c\":-1.0,\n\"no2_p\":1.0,\n\"no3_c\":1.0,\n\"no3_p\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_19295\",\n\"notes\":{\n\"EC Number\":\"two-component system, oxyanion-binding sensor\"\n}\n},\n{\n\"id\":\"NO3R1\",\n\"name\":\"Nitrate reductase (Ubiquinol-8)\",\n\"metabolites\":{\n\"h2o_c\":1,\n\"no2_c\":1,\n\"no3_c\":-1,\n\"q_c\":1,\n\"qh2_c\":-1\n},\n\"lower_bound\":0,\n\"upper_bound\":1000,\n\"gene_reaction_rule\":\"CQW49_19300 or CQW49_17890\",\n\"subsystem\":{\n\"mtw00910\":\"Nitrogen metabolism\",\n\"mtw01100\":\"Metabolic pathways\",\n\"mtw01120\":\"Microbial metabolism in diverse environments\"\n},\n\"notes\":{\n\"EC Number\":\"assimilatory nitrate reductase catalytic subunit [EC:1.7.99.-]\"\n}\n},\n{\n\"id\":\"NTRIR2x\",\n\"name\":\"Nitrite Reductase (NADH)\",\n\"metabolites\":{\n\"h2o_c\":2.0,\n\"h_c\":-5.0,\n\"nad_c\":3.0,\n\"nadh_c\":-3.0,\n\"nh4_c\":1.0,\n\"no2_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_19305 or CQW49_19310\",\n\"subsystem\":{\n\"mtw00910\":\"Nitrogen metabolism\",\n\"mtw01100\":\"Metabolic pathways\",\n\"mtw01120\":\"Microbial metabolism in diverse environments\"\n},\n\"notes\":{\n\"EC Number\":\"nitrite reductase (NADH) small subunit [EC:1.7.1.15]\"\n}\n},\n{\n\"id\":\"PAMMOipp\",\n\"name\":\"particulate ammonia monooxygenase\",\n\"metabolites\":{\n\"h2o_p\":1,\n\"h_p\":1,\n\"ham_p\":1,\n\"nh4_p\":-1,\n\"o2_p\":-1,\n\"q_c\":1,\n\"qh2_c\":-1\n},\n\"lower_bound\":0,\n\"upper_bound\":1000,\n\"gene_reaction_rule\":\"CQW49_10250 and (CQW49_10255 or CQW49_01220) and CQW49_10260\"\n},\n{\n\"id\":\"HAMtpp\",\n\"name\":\"Diffusion Hydroxylamine between Periplasm and Cytosol\",\n\"metabolites\":{\n\"ham_c\":1.0,\n\"ham_p\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"NO2tpp\",\n\"name\":\"Diffusion Hydroxylamine between Periplasm and Cytosol\",\n\"metabolites\":{\n\"no2_c\":1.0,\n\"no2_p\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"NORZ2\",\n\"name\":\"Nitric oxide reductase (cytochrome c)\",\n\"metabolites\":{\n\"ficytc_c\":2.0,\n\"focytc_c\":-2.0,\n\"h2o_c\":1,\n\"h_c\":-2.0,\n\"n2o_c\":1,\n\"no_c\":-2.0\n},\n\"lower_bound\":0,\n\"upper_bound\":1000,\n\"gene_reaction_rule\":\"CQW49_22935\"\n},\n{\n\"id\":\"NIT_mc\",\n\"name\":\"Nitrogenase\",\n\"metabolites\":{\n\"adp_c\":16.0,\n\"atp_c\":-16.0,\n\"fdxox_c\":4.0,\n\"fdxrd_c\":-4.0,\n\"h2_c\":1.0,\n\"h2o_c\":-16.0,\n\"h_c\":14.0,\n\"n2_c\":-1.0,\n\"nh4_c\":2.0,\n\"pi_c\":16.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_08720 and CQW49_08725\"\n},\n{\n\"id\":\"SMMOi\",\n\"name\":\"soluble Methane Monooxygenase\",\n\"metabolites\":{\n\"ch4_c\":-1.0,\n\"h2o_c\":1.0,\n\"h_c\":-1.0,\n\"meoh_c\":1.0,\n\"nad_c\":1.0,\n\"nadh_c\":-1.0,\n\"o2_c\":-1.0\n},\n\"lower_bound\":0,\n\"upper_bound\":1000,\n\"gene_reaction_rule\":\"CQW49_12480 and CQW49_12475 and CQW49_12465 and CQW49_12470 and CQW49_12455 and CQW49_12485 and CQW49_12495\"\n},\n{\n\"id\":\"CH4trpp\",\n\"name\":\"Diffusion CH4 between Periplasm and Cytosol\",\n\"metabolites\":{\n\"ch4_c\":1.0,\n\"ch4_p\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"ANHMK\",\n\"name\":\"1,6-anhydrous-N-Acetylmuramate kinase\",\n\"metabolites\":{\n\"acmum6p_c\":1.0,\n\"adp_c\":1.0,\n\"anhm_c\":-1.0,\n\"atp_c\":-1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_01435\",\n\"notes\":{\n\"EC Number\":\"anhydro-N-acetylmuramic acid kinase [EC:2.7.1.170]\"\n}\n},\n{\n\"id\":\"METSOXR2\",\n\"name\":\"L-methionine-R-sulfoxide reductase\",\n\"metabolites\":{\n\"h2o_c\":1.0,\n\"met__L_c\":1.0,\n\"metsox_R__L_c\":-1.0,\n\"trdox_c\":1.0,\n\"trdrd_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_16785 and CQW49_12190\",\n\"notes\":{\n\"EC Number\":\"peptide-methionine (R)-S-oxide reductase [EC:1.8.4.12]\"\n}\n},\n{\n\"id\":\"NADPHQR2\",\n\"name\":\"NADPH Quinone Reductase (Ubiquinone-8)\",\n\"metabolites\":{\n\"h_c\":-1,\n\"nadp_c\":1,\n\"nadph_c\":-1,\n\"q_c\":-1,\n\"qh2_c\":1\n},\n\"lower_bound\":0,\n\"upper_bound\":1000,\n\"gene_reaction_rule\":\"CQW49_15550 or CQW49_18215\",\n\"notes\":{\n\"EC Number\":\"NADPH:quinone reductase [EC:1.6.5.5]\"\n}\n},\n{\n\"id\":\"QRr\",\n\"name\":\"QRr\",\n\"metabolites\":{\n\"h_c\":-1.0,\n\"nadp_c\":1.0,\n\"nadph_c\":-1.0,\n\"q_c\":-1.0,\n\"qh2_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_21560\",\n\"notes\":{\n\"EC Number\":\"NADPH:quinone reductase [EC:1.6.5.5]\"\n}\n},\n{\n\"id\":\"UACMAMO\",\n\"name\":\"UDP-N-acetyl-D-mannosamine oxidoreductase\",\n\"metabolites\":{\n\"h2o_c\":-1.0,\n\"h_c\":3.0,\n\"nad_c\":-2.0,\n\"nadh_c\":2.0,\n\"uacmam_c\":-1.0,\n\"uacmamu_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_00740\",\n\"subsystem\":{\n\"mtw00520\":\"Amino sugar and nucleotide sugar metabolism\",\n\"mtw01100\":\"Metabolic pathways\"\n},\n\"notes\":{\n\"EC Number\":\"UDP-N-acetyl-D-glucosamine dehydrogenase [EC:1.1.1.136]\"\n}\n},\n{\n\"id\":\"NDPK6\",\n\"name\":\"Nucleoside-diphosphate kinase (ATP:dUDP)\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"dudp_c\":-1.0,\n\"dutp_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_01360\",\n\"subsystem\":{\n\"mtw00230\":\"Purine metabolism\",\n\"mtw00240\":\"Pyrimidine metabolism\",\n\"mtw01100\":\"Metabolic pathways\",\n\"mtw01110\":\"Biosynthesis of secondary metabolites\",\n\"mtw01130\":\"Biosynthesis of antibiotics\"\n},\n\"notes\":{\n\"EC Number\":\"nucleoside-diphosphate kinase [EC:2.7.4.6]\"\n}\n},\n{\n\"id\":\"NDPK9\",\n\"name\":\"Nucleoside diphosphate kinase  ATPIDP \",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"idp_c\":-1.0,\n\"itp_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_01360\",\n\"subsystem\":{\n\"mtw00230\":\"Purine metabolism\",\n\"mtw00240\":\"Pyrimidine metabolism\",\n\"mtw01100\":\"Metabolic pathways\",\n\"mtw01110\":\"Biosynthesis of secondary metabolites\",\n\"mtw01130\":\"Biosynthesis of antibiotics\"\n},\n\"notes\":{\n\"EC Number\":\"nucleoside-diphosphate kinase [EC:2.7.4.6]\"\n}\n},\n{\n\"id\":\"NDPK10\",\n\"name\":\"Nucleoside-diphosphate kinase (ATP dIDP)\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"didp_c\":-1.0,\n\"ditp_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_01360\",\n\"subsystem\":{\n\"mtw00230\":\"Purine metabolism\",\n\"mtw00240\":\"Pyrimidine metabolism\",\n\"mtw01100\":\"Metabolic pathways\",\n\"mtw01110\":\"Biosynthesis of secondary metabolites\",\n\"mtw01130\":\"Biosynthesis of antibiotics\"\n},\n\"notes\":{\n\"EC Number\":\"nucleoside-diphosphate kinase [EC:2.7.4.6]\"\n}\n},\n{\n\"id\":\"LIPOS\",\n\"name\":\"Lipoate synthase\",\n\"metabolites\":{\n\"2fe2s_c\":1.0,\n\"4fe4s_c\":-1.0,\n\"amet_c\":-2.0,\n\"dad_5_c\":2.0,\n\"fe2_c\":2.0,\n\"h_c\":-1.0,\n\"lipopb_c\":1.0,\n\"met__L_c\":2.0,\n\"nad_c\":-1.0,\n\"nadh_c\":1.0,\n\"octapb_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_01705\",\n\"subsystem\":{\n\"mtw00785\":\"Lipoic acid metabolism\",\n\"mtw01100\":\"Metabolic pathways\"\n},\n\"notes\":{\n\"EC Number\":\"lipoyl synthase [EC:2.8.1.8]\"\n}\n},\n{\n\"id\":\"GTHRDHpp\",\n\"name\":\"Glutathione hydralase (periplasmic)\",\n\"metabolites\":{\n\"cgly_c\":1.0,\n\"glu__L_c\":1.0,\n\"gthrd_c\":-1.0,\n\"h2o_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_02400\",\n\"subsystem\":{\n\"mtw00430\":\"Taurine and hypotaurine metabolism\",\n\"mtw00460\":\"Cyanoamino acid metabolism\",\n\"mtw00480\":\"Glutathione metabolism\",\n\"mtw01100\":\"Metabolic pathways\"\n},\n\"notes\":{\n\"EC Number\":\"gamma-glutamyltranspeptidase / glutathione hydrolase [EC:2.3.2.2 3.4.19.13]\"\n}\n},\n{\n\"id\":\"PPS\",\n\"name\":\"Phosphoenolpyruvate synthase\",\n\"metabolites\":{\n\"amp_c\":1.0,\n\"atp_c\":-1.0,\n\"h2o_c\":-1.0,\n\"h_c\":2.0,\n\"pep_c\":1.0,\n\"pi_c\":1.0,\n\"pyr_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_02415\",\n\"subsystem\":{\n\"mtw00620\":\"Pyruvate metabolism\",\n\"mtw00680\":\"Methane metabolism\",\n\"mtw01100\":\"Metabolic pathways\",\n\"mtw01120\":\"Microbial metabolism in diverse environments\",\n\"mtw01200\":\"Carbon metabolism\"\n},\n\"notes\":{\n\"EC Number\":\"pyruvate, water dikinase [EC:2.7.9.2]\"\n}\n},\n{\n\"id\":\"ORNTA\",\n\"name\":\"Ornithine transaminase\",\n\"metabolites\":{\n\"akg_c\":-1.0,\n\"glu5sa_c\":1.0,\n\"glu__L_c\":1.0,\n\"orn_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_02635 or CQW49_17895\",\n\"subsystem\":{\n\"mtw00330\":\"Arginine and proline metabolism\",\n\"mtw01100\":\"Metabolic pathways\",\n\"mtw01110\":\"Biosynthesis of secondary metabolites\",\n\"mtw01130\":\"Biosynthesis of antibiotics\"\n}\n},\n{\n\"id\":\"CLPNS160\",\n\"name\":\"Cardiolipin synthase (n-16:0)\",\n\"metabolites\":{\n\"cdpdhdecg_c\":-1,\n\"clpnd160_c\":1,\n\"cmp_c\":1,\n\"pg160_c\":-1\n},\n\"lower_bound\":-1000,\n\"upper_bound\":1000,\n\"gene_reaction_rule\":\"CQW49_02865\"\n},\n{\n\"id\":\"CLPNS161\",\n\"name\":\"Cardiolipin synthase (n-16:1)\",\n\"metabolites\":{\n\"cdpdhdec9eg_c\":-1,\n\"clpnd161_c\":1,\n\"cmp_c\":1,\n\"pg161_c\":-1\n},\n\"lower_bound\":-1000,\n\"upper_bound\":1000,\n\"gene_reaction_rule\":\"CQW49_02865\"\n},\n{\n\"id\":\"CLPNS180\",\n\"name\":\"Cardiolipin synthase (n-18:0)\",\n\"metabolites\":{\n\"cdpdodecg_c\":-1,\n\"clpnd180_c\":1,\n\"cmp_c\":1,\n\"pg180_c\":-1\n},\n\"lower_bound\":-1000,\n\"upper_bound\":1000,\n\"gene_reaction_rule\":\"CQW49_02865\"\n},\n{\n\"id\":\"CLPNS181\",\n\"name\":\"Cardiolipin synthase (n-18:1)\",\n\"metabolites\":{\n\"cdpdodec11eg_c\":-1,\n\"clpnd181_c\":1,\n\"cmp_c\":1,\n\"pg181_c\":-1\n},\n\"lower_bound\":-1000,\n\"upper_bound\":1000,\n\"gene_reaction_rule\":\"CQW49_02865\"\n},\n{\n\"id\":\"SHSL2\",\n\"name\":\"o-succinylhomoserine sulfhydrylase\",\n\"metabolites\":{\n\"h2s_c\":-1.0,\n\"h_c\":1.0,\n\"lhcys_c\":1.0,\n\"succ_c\":1.0,\n\"suchms_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_02960\",\n\"subsystem\":{\n\"mtw00270\":\"Cysteine and methionine metabolism\",\n\"mtw00920\":\"Sulfur metabolism\",\n\"mtw01100\":\"Metabolic pathways\"\n},\n\"notes\":{\n\"EC Number\":\"O-succinylhomoserine sulfhydrylase [EC:2.5.1.-]\"\n}\n},\n{\n\"id\":\"XPPT\",\n\"name\":\"Xanthine phosphoribosyltransferase\",\n\"metabolites\":{\n\"ppi_c\":1.0,\n\"prpp_c\":-1.0,\n\"xan_c\":-1.0,\n\"xmp_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_03930\",\n\"subsystem\":{\n\"mtw00230\":\"Purine metabolism\",\n\"mtw01100\":\"Metabolic pathways\",\n\"mtw01110\":\"Biosynthesis of secondary metabolites\"\n},\n\"notes\":{\n\"EC Number\":\"xanthine phosphoribosyltransferase [EC:2.4.2.22]\"\n}\n},\n{\n\"id\":\"MSAR\",\n\"name\":\"Malonic semialdehyde reductase\",\n\"metabolites\":{\n\"3hpp_c\":1.0,\n\"h_c\":-1.0,\n\"msa_c\":-1.0,\n\"nadp_c\":1.0,\n\"nadph_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_04245 or CQW49_18335\",\n\"subsystem\":{\n\"mtw00240\":\"Pyrimidine metabolism\",\n\"mtw01100\":\"Metabolic pathways\"\n},\n\"notes\":{\n\"EC Number\":\"3-hydroxypropanoate dehydrogenase [EC:1.1.1.-]\"\n}\n},\n{\n\"id\":\"BACCL\",\n\"name\":\"Biotin acetyl CoA carboxylase ligase\",\n\"metabolites\":{\n\"atp_c\":-1.0,\n\"btamp_c\":1.0,\n\"btn_c\":-1.0,\n\"h_c\":-1.0,\n\"ppi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_05280\",\n\"subsystem\":{\n\"mtw00780\":\"Biotin metabolism\",\n\"mtw01100\":\"Metabolic pathways\"\n},\n\"notes\":{\n\"EC Number\":\"BirA family transcriptional regulator, biotin operon repressor / biotin---[acetyl-CoA-carboxylase] ligase [EC:6.3.4.15]\"\n}\n},\n{\n\"id\":\"HGNTOR\",\n\"name\":\"Homogentisateoxygen 1 2 oxidoreductase  decyclizing \",\n\"metabolites\":{\n\"4mlacac_c\":1.0,\n\"h_c\":1.0,\n\"hgentis_c\":-1.0,\n\"o2_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_05640\",\n\"subsystem\":{\n\"mtw00350\":\"Tyrosine metabolism\",\n\"mtw00643\":\"Styrene degradation\",\n\"mtw01100\":\"Metabolic pathways\",\n\"mtw01120\":\"Microbial metabolism in diverse environments\"\n},\n\"notes\":{\n\"EC Number\":\"homogentisate 1,2-dioxygenase [EC:1.13.11.5]\"\n}\n},\n{\n\"id\":\"34HPPOR\",\n\"name\":\"4 Hydroxyphenylpyruvateoxygen oxidoreductase\",\n\"metabolites\":{\n\"34hpp_c\":-1.0,\n\"co2_c\":1.0,\n\"hgentis_c\":1.0,\n\"o2_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_05645\",\n\"subsystem\":{\n\"mtw00130\":\"Ubiquinone and other terpenoid-quinone biosynthesis\",\n\"mtw00350\":\"Tyrosine metabolism\",\n\"mtw00360\":\"Phenylalanine metabolism\",\n\"mtw01100\":\"Metabolic pathways\"\n},\n\"notes\":{\n\"EC Number\":\"4-hydroxyphenylpyruvate dioxygenase [EC:1.13.11.27]\"\n}\n},\n{\n\"id\":\"FTHFCL\",\n\"name\":\"5 formethyltetrahydrofolate cyclo ligase\",\n\"metabolites\":{\n\"5fthf_c\":-1.0,\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"methf_c\":1.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_06175\",\n\"subsystem\":{\n\"mtw00670\":\"One carbon pool by folate\",\n\"mtw01100\":\"Metabolic pathways\"\n},\n\"notes\":{\n\"EC Number\":\"5-formyltetrahydrofolate cyclo-ligase [EC:6.3.3.2]\"\n}\n},\n{\n\"id\":\"CPPPGO2\",\n\"name\":\"Oxygen Independent coproporphyrinogen-III oxidase\",\n\"metabolites\":{\n\"amet_c\":-2.0,\n\"co2_c\":2.0,\n\"cpppg3_c\":-1.0,\n\"dad_5_c\":2.0,\n\"met__L_c\":2.0,\n\"pppg9_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_06290\",\n\"subsystem\":{\n\"mtw00860\":\"Porphyrin and chlorophyll metabolism\",\n\"mtw01100\":\"Metabolic pathways\",\n\"mtw01110\":\"Biosynthesis of secondary metabolites\"\n},\n\"notes\":{\n\"EC Number\":\"oxygen-independent coproporphyrinogen III oxidase [EC:1.3.98.3]\"\n}\n},\n{\n\"id\":\"GLUDy\",\n\"name\":\"Glutamate dehydrogenase (NADP)\",\n\"metabolites\":{\n\"akg_c\":1.0,\n\"glu__L_c\":-1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"nadp_c\":-1.0,\n\"nadph_c\":1.0,\n\"nh4_c\":1.0\n},\n\"lower_bound\":0,\n\"upper_bound\":1000,\n\"gene_reaction_rule\":\"CQW49_06715\",\n\"subsystem\":{\n\"mtw00220\":\"Arginine biosynthesis\",\n\"mtw00250\":\"Alanine, aspartate and glutamate metabolism\",\n\"mtw00471\":\"D-Glutamine and D-glutamate metabolism\",\n\"mtw00910\":\"Nitrogen metabolism\",\n\"mtw01100\":\"Metabolic pathways\",\n\"mtw01120\":\"Microbial metabolism in diverse environments\",\n\"mtw01200\":\"Carbon metabolism\"\n},\n\"notes\":{\n\"EC Number\":\"glutamate dehydrogenase (NAD(P)+) [EC:1.4.1.3]\"\n}\n},\n{\n\"id\":\"GLUDxi\",\n\"name\":\"Glutamate dehydrogenase  NAD \",\n\"metabolites\":{\n\"akg_c\":1.0,\n\"glu__L_c\":-1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"nad_c\":-1.0,\n\"nadh_c\":1.0,\n\"nh4_c\":1.0\n},\n\"lower_bound\":0,\n\"upper_bound\":1000,\n\"gene_reaction_rule\":\"CQW49_06715\",\n\"subsystem\":{\n\"mtw00220\":\"Arginine biosynthesis\",\n\"mtw00250\":\"Alanine, aspartate and glutamate metabolism\",\n\"mtw00471\":\"D-Glutamine and D-glutamate metabolism\",\n\"mtw00910\":\"Nitrogen metabolism\",\n\"mtw01100\":\"Metabolic pathways\",\n\"mtw01120\":\"Microbial metabolism in diverse environments\",\n\"mtw01200\":\"Carbon metabolism\"\n},\n\"notes\":{\n\"EC Number\":\"glutamate dehydrogenase (NAD(P)+) [EC:1.4.1.3]\"\n}\n},\n{\n\"id\":\"UDPGDC\",\n\"name\":\"UDP-glucuronate C-4'' decarboxylase\",\n\"metabolites\":{\n\"co2_c\":1.0,\n\"nad_c\":-1.0,\n\"nadh_c\":1.0,\n\"udpLa4o_c\":1.0,\n\"udpglcur_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_06900\",\n\"subsystem\":{\n\"mtw00520\":\"Amino sugar and nucleotide sugar metabolism\",\n\"mtw01100\":\"Metabolic pathways\"\n},\n\"notes\":{\n\"EC Number\":\"UDP-glucuronate decarboxylase [EC:4.1.1.35]\"\n}\n},\n{\n\"id\":\"HCITS\",\n\"name\":\"Homocitrate synthase\",\n\"metabolites\":{\n\"accoa_c\":-1.0,\n\"akg_c\":-1.0,\n\"coa_c\":1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"hcit_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_08665\",\n\"subsystem\":{\n\"mtw00620\":\"Pyruvate metabolism\"\n},\n\"notes\":{\n\"EC Number\":\"homocitrate synthase NifV [EC:2.3.3.14]\"\n}\n},\n{\n\"id\":\"TRPAS2\",\n\"name\":\"Tryptophanase (L-tryptophan)\",\n\"metabolites\":{\n\"h2o_c\":-1,\n\"indole_c\":1,\n\"nh4_c\":1,\n\"pyr_c\":1,\n\"trp_L_c\":-1\n},\n\"lower_bound\":0,\n\"upper_bound\":1000,\n\"gene_reaction_rule\":\"CQW49_09160\",\n\"subsystem\":{\n\"mtw00380\":\"Tryptophan metabolism\",\n\"mtw01100\":\"Metabolic pathways\"\n},\n\"notes\":{\n\"EC Number\":\"tryptophanase [EC:4.1.99.1]\"\n}\n},\n{\n\"id\":\"NTPTP1\",\n\"name\":\"Nucleoside triphosphate tripolyhydrolase\",\n\"metabolites\":{\n\"dgsn_c\":1.0,\n\"dgtp_c\":-1.0,\n\"h2o_c\":-1.0,\n\"pppi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_09415\",\n\"subsystem\":{\n\"mtw00230\":\"Purine metabolism\",\n\"mtw01100\":\"Metabolic pathways\"\n},\n\"notes\":{\n\"EC Number\":\"dGTPase [EC:3.1.5.1]\"\n}\n},\n{\n\"id\":\"HOPNTAL\",\n\"name\":\"4-hydroxy-2-oxopentanoate aldolase\",\n\"metabolites\":{\n\"4h2opntn_c\":-1.0,\n\"acald_c\":1.0,\n\"pyr_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_09715\",\n\"subsystem\":{\n\"mtw00360\":\"Phenylalanine metabolism\",\n\"mtw00362\":\"Benzoate degradation\",\n\"mtw00621\":\"Dioxin degradation\",\n\"mtw01100\":\"Metabolic pathways\",\n\"mtw01120\":\"Microbial metabolism in diverse environments\",\n\"mtw01220\":\"Degradation of aromatic compounds\"\n},\n\"notes\":{\n\"EC Number\":\"4-hydroxy 2-oxovalerate aldolase [EC:4.1.3.39]\"\n}\n},\n{\n\"id\":\"CCGS\",\n\"name\":\"7-cyano-7-carbaguanine synthase\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"cdg_c\":-1.0,\n\"h2o_c\":1.0,\n\"h_c\":1.0,\n\"nh4_c\":-1.0,\n\"pi_c\":1.0,\n\"preq0_c\":1.0\n},\n\"lower_bound\":-1000,\n\"upper_bound\":0,\n\"gene_reaction_rule\":\"CQW49_10130\",\n\"subsystem\":{\n\"mtw00790\":\"Folate biosynthesis\",\n\"mtw01100\":\"Metabolic pathways\"\n},\n\"notes\":{\n\"EC Number\":\"7-cyano-7-deazaguanine synthase [EC:6.3.4.20]\"\n}\n},\n{\n\"id\":\"DAAD\",\n\"name\":\"D-Amino acid dehydrogenase\",\n\"metabolites\":{\n\"ala__D_c\":-1.0,\n\"fad_c\":-1.0,\n\"fadh2_c\":1.0,\n\"h2o_c\":-1.0,\n\"nh4_c\":1.0,\n\"pyr_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_10980\",\n\"subsystem\":{\n\"mtw00360\":\"Phenylalanine metabolism\",\n\"mtw01100\":\"Metabolic pathways\"\n},\n\"notes\":{\n\"EC Number\":\"D-amino-acid dehydrogenase [EC:1.4.5.1]\"\n}\n},\n{\n\"id\":\"HMGL\",\n\"name\":\"HMGL\",\n\"metabolites\":{\n\"acac_c\":1.0,\n\"accoa_c\":1.0,\n\"hmgcoa_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_12940\",\n\"subsystem\":{\n\"mtw00072\":\"Synthesis and degradation of ketone bodies\",\n\"mtw00280\":\"Valine, leucine and isoleucine degradation\",\n\"mtw00281\":\"Geraniol degradation\",\n\"mtw00650\":\"Butanoate metabolism\",\n\"mtw01100\":\"Metabolic pathways\"\n},\n\"notes\":{\n\"EC Number\":\"hydroxymethylglutaryl-CoA lyase [EC:4.1.3.4]\"\n}\n},\n{\n\"id\":\"HEX7\",\n\"name\":\"Hexokinase (D-fructose:ATP)\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"f6p_c\":1.0,\n\"fru_c\":-1.0,\n\"h_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_15360\",\n\"subsystem\":{\n\"mtw00051\":\"Fructose and mannose metabolism\",\n\"mtw00500\":\"Starch and sucrose metabolism\",\n\"mtw00520\":\"Amino sugar and nucleotide sugar metabolism\",\n\"mtw01100\":\"Metabolic pathways\"\n}\n},\n{\n\"id\":\"LIPOCT\",\n\"name\":\"Lipoyl(octanoyl) transferase\",\n\"metabolites\":{\n\"ACP_c\":1.0,\n\"h_c\":-1.0,\n\"ocACP_c\":-1.0,\n\"octapb_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_15505\",\n\"subsystem\":{\n\"mtw00785\":\"Lipoic acid metabolism\",\n\"mtw01100\":\"Metabolic pathways\"\n},\n\"notes\":{\n\"EC Number\":\"lipoyl(octanoyl) transferase [EC:2.3.1.181]\"\n}\n},\n{\n\"id\":\"PFK_ppi\",\n\"name\":\"Phosphofructokinase (ppi-dependent\",\n\"metabolites\":{\n\"f6p_c\":-1.0,\n\"fdp_c\":1.0,\n\"h_c\":1.0,\n\"pi_c\":1.0,\n\"ppi_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_16115\",\n\"subsystem\":{\n\"mtw00010\":\"Glycolysis / Gluconeogenesis\",\n\"mtw00030\":\"Pentose phosphate pathway\",\n\"mtw00051\":\"Fructose and mannose metabolism\",\n\"mtw00052\":\"Galactose metabolism\",\n\"mtw00680\":\"Methane metabolism\",\n\"mtw01100\":\"Metabolic pathways\",\n\"mtw01110\":\"Biosynthesis of secondary metabolites\",\n\"mtw01120\":\"Microbial metabolism in diverse environments\",\n\"mtw01130\":\"Biosynthesis of antibiotics\"\n},\n\"notes\":{\n\"EC Number\":\"ATP-dependent phosphofructokinase / diphosphate-dependent phosphofructokinase [EC:2.7.1.11 2.7.1.90]\"\n}\n},\n{\n\"id\":\"PFK\",\n\"name\":\"Phosphofructokinase\",\n\"metabolites\":{\n\"adp_c\":1,\n\"atp_c\":-1,\n\"f6p_c\":-1,\n\"fdp_c\":1,\n\"h_c\":1\n},\n\"lower_bound\":-1000,\n\"upper_bound\":1000,\n\"gene_reaction_rule\":\"\"\n},\n{\n\"id\":\"SQLC\",\n\"name\":\"Squalene mutase (cyclizing)\",\n\"metabolites\":{\n\"dplpt_c\":1.0,\n\"sql_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_17110\",\n\"subsystem\":{\n\"mtw00909\":\"Sesquiterpenoid and triterpenoid biosynthesis\",\n\"mtw01110\":\"Biosynthesis of secondary metabolites\"\n},\n\"notes\":{\n\"EC Number\":\"squalene-hopene/tetraprenyl-beta-curcumene cyclase [EC:5.4.99.17 4.2.1.129]\"\n}\n},\n{\n\"id\":\"SQLC2\",\n\"name\":\"Squalene mutase (cyclizing)\",\n\"metabolites\":{\n\"dpterol_c\":1.0,\n\"h2o_c\":-1.0,\n\"sql_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_17110\",\n\"subsystem\":{\n\"mtw00909\":\"Sesquiterpenoid and triterpenoid biosynthesis\",\n\"mtw01110\":\"Biosynthesis of secondary metabolites\"\n},\n\"notes\":{\n\"EC Number\":\"squalene-hopene/tetraprenyl-beta-curcumene cyclase [EC:5.4.99.17 4.2.1.129]\"\n}\n},\n{\n\"id\":\"ACM6PH\",\n\"name\":\"N-acetylmuramate 6-phosphate hydrolase\",\n\"metabolites\":{\n\"acgam6p_c\":1.0,\n\"acmum6p_c\":-1.0,\n\"h2o_c\":-1.0,\n\"lac__D_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_17220\",\n\"subsystem\":{\n\"mtw00520\":\"Amino sugar and nucleotide sugar metabolism\",\n\"mtw01100\":\"Metabolic pathways\"\n},\n\"notes\":{\n\"EC Number\":\"N-acetylmuramic acid 6-phosphate etherase [EC:4.2.1.126]\"\n}\n},\n{\n\"id\":\"CHOLD\",\n\"name\":\"Choline dehydrogenase\",\n\"metabolites\":{\n\"betald_c\":1.0,\n\"chol_c\":-1.0,\n\"h_c\":1.0,\n\"nad_c\":-1.0,\n\"nadh_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_17240\",\n\"subsystem\":{\n\"mtw00260\":\"Glycine, serine and threonine metabolism\",\n\"mtw01100\":\"Metabolic pathways\"\n},\n\"notes\":{\n\"EC Number\":\"choline dehydrogenase [EC:1.1.99.1]\"\n}\n},\n{\n\"id\":\"TMDS3\",\n\"name\":\"Thymidylate synthase (FAD dependent)\",\n\"metabolites\":{\n\"dtmp_c\":1.0,\n\"dump_c\":-1.0,\n\"h_c\":-1.0,\n\"mlthf_c\":-1.0,\n\"nadp_c\":1.0,\n\"nadph_c\":-1.0,\n\"thf_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_18435\",\n\"subsystem\":{\n\"mtw00240\":\"Pyrimidine metabolism\",\n\"mtw00670\":\"One carbon pool by folate\",\n\"mtw01100\":\"Metabolic pathways\"\n},\n\"notes\":{\n\"EC Number\":\"thymidylate synthase (FAD) [EC:2.1.1.148]\"\n}\n},\n{\n\"id\":\"OXADC\",\n\"name\":\"Oxalate decarboxylase\",\n\"metabolites\":{\n\"co2_c\":1.0,\n\"for_c\":1.0,\n\"h_c\":-1.0,\n\"oxa_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_20020\",\n\"subsystem\":{\n\"mtw00630\":\"Glyoxylate and dicarboxylate metabolism\",\n\"mtw01100\":\"Metabolic pathways\"\n},\n\"notes\":{\n\"EC Number\":\"oxalate decarboxylase [EC:4.1.1.2]\"\n}\n},\n{\n\"id\":\"METGL\",\n\"name\":\"METGL\",\n\"metabolites\":{\n\"2obut_c\":1.0,\n\"ch4s_c\":1.0,\n\"h2o_c\":-1.0,\n\"met__L_c\":-1.0,\n\"nh4_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_21030\",\n\"subsystem\":{\n\"mtw00270\":\"Cysteine and methionine metabolism\",\n\"mtw00450\":\"Selenocompound metabolism\",\n\"mtw01100\":\"Metabolic pathways\"\n},\n\"notes\":{\n\"EC Number\":\"methionine-gamma-lyase [EC:4.4.1.11]\"\n}\n},\n{\n\"id\":\"UREA\",\n\"name\":\"Urease\",\n\"metabolites\":{\n\"co2_c\":1.0,\n\"h2o_c\":-1.0,\n\"h_c\":-2.0,\n\"nh4_c\":2.0,\n\"urea_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_21325 and CQW49_21330 and CQW49_21335\",\n\"notes\":{\n\"EC Number\":\"urease accessory protein\"\n}\n},\n{\n\"id\":\"SCYSDS\",\n\"name\":\"SUF Cysteine desulfuration\",\n\"metabolites\":{\n\"ala__L_c\":1.0,\n\"cys__L_c\":-1.0,\n\"sufse_c\":-1.0,\n\"sufsesh_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_06110 and CQW49_21985\",\n\"notes\":{\n\"EC Number\":\"cysteine desulfuration protein SufE\"\n}\n},\n{\n\"id\":\"MOCDS\",\n\"name\":\"Molybdopterin cytidine dinucleotide synthase\",\n\"metabolites\":{\n\"ctp_c\":-1.0,\n\"h_c\":-1.0,\n\"moco_c\":-1.0,\n\"mococdp_c\":1.0,\n\"ppi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_22035\",\n\"subsystem\":{\n\"mtw00790\":\"Folate biosynthesis\"\n},\n\"notes\":{\n\"EC Number\":\"molybdenum cofactor cytidylyltransferase [EC:2.7.7.76]\"\n}\n},\n{\n\"id\":\"MCITD\",\n\"name\":\"2-methylcitrate dehydratase\",\n\"metabolites\":{\n\"2mcacn_c\":1.0,\n\"2mcit_c\":-1.0,\n\"h2o_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_22910\",\n\"subsystem\":{\n\"mtw00640\":\"Propanoate metabolism\",\n\"mtw01100\":\"Metabolic pathways\"\n},\n\"notes\":{\n\"EC Number\":\"2-methylcitrate dehydratase [EC:4.2.1.79]\"\n}\n},\n{\n\"id\":\"NMNS\",\n\"name\":\"NMN synthetase\",\n\"metabolites\":{\n\"h_c\":-1.0,\n\"ncam_c\":-1.0,\n\"nmn_c\":1.0,\n\"ppi_c\":1.0,\n\"prpp_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_23910\",\n\"subsystem\":{\n\"mtw00760\":\"Nicotinate and nicotinamide metabolism\",\n\"mtw01100\":\"Metabolic pathways\"\n},\n\"notes\":{\n\"EC Number\":\"nicotinamide phosphoribosyltransferase [EC:2.4.2.12]\"\n}\n},\n{\n\"id\":\"DHCYTCPEROX\",\n\"name\":\"di_haem_cytochrome_c_peroxidase\",\n\"metabolites\":{\n\"ficytc_c\":2.0,\n\"focytc_c\":-2.0,\n\"h2o2_p\":-1.0,\n\"h2o_p\":2.0,\n\"h_c\":-2.0\n},\n\"lower_bound\":0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_01205\",\n\"subsystem\":\"superoxide_radicals_degradation\",\n\"notes\":{\n\"GENE ASSOCIATION\":[\n\"( META1_2969 )\"\n],\n\"GENERIC\":[\n\"false\"\n],\n\"HOLE\":[\n\"false\"\n],\n\"PROTEIN ASSOCIATION\":[\n\"( META1_2969 )\"\n],\n\"PROTEIN CLASS\":[\n\"1.11.1.5\"\n],\n\"SCORE\":[\n\"NA\"\n],\n\"STATUS\":[\n\"NA\"\n],\n\"TYPE\":[\n\"small\"\n]\n}\n},\n{\n\"id\":\"PPK2\",\n\"name\":\"Polyphosphate kinase\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"ppi_c\":-1.0,\n\"pppi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_02850\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"PPK2\",\n\"PPK2r\"\n]\n}\n},\n{\n\"id\":\"HAMR\",\n\"name\":\"Hydroxylamine reductase\",\n\"metabolites\":{\n\"h2o_c\":1.0,\n\"h_c\":-2.0,\n\"ham_c\":-1.0,\n\"nad_c\":1.0,\n\"nadh_c\":-1.0,\n\"nh4_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"CQW49_14985\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"HAMR\"\n]\n}\n},\n{\n\"id\":\"HAORipp\",\n\"name\":\"Hydroxylamine 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            "_model_module": "escher",
            "_model_module_version": "1.7.3",
            "_model_name": "EscherMapModel",
            "_view_count": null,
            "_view_module": "escher",
            "_view_module_version": "1.7.3",
            "_view_name": "EscherMapView",
            "allow_building_duplicate_reactions": null,
            "and_method_in_gene_reaction_rule": null,
            "canvas_size_and_loc": null,
            "cofactors": null,
            "disabled_buttons": null,
            "embedded_css": null,
            "enable_editing": null,
            "enable_keys": false,
            "enable_keys_with_tooltip": null,
            "enable_search": null,
            "enable_tooltips": false,
            "full_screen_button": {
              "enable_keys": true,
              "scroll_behavior": "pan",
              "enable_editing": true,
              "menu": "all",
              "enable_tooltips": [
                "label"
              ]
            },
            "gene_data": null,
            "gene_font_size": null,
            "height": 500,
            "hide_all_labels": null,
            "hide_secondary_metabolites": null,
            "highlight_missing": null,
            "identifiers_on_map": null,
            "layout": "IPY_MODEL_3d82889187184c34a84cb38400b14045",
            "marker_radius": null,
            "menu": null,
            "metabolite_compare_style": null,
            "metabolite_data": null,
            "metabolite_no_data_color": null,
            "metabolite_no_data_size": null,
            "metabolite_scale": null,
            "metabolite_scale_preset": null,
            "metabolite_styles": null,
            "never_ask_before_quit": null,
            "primary_metabolite_radius": null,
            "reaction_compare_style": null,
            "reaction_data": null,
            "reaction_no_data_color": null,
            "reaction_no_data_size": null,
            "reaction_scale": null,
            "reaction_scale_preset": null,
            "reaction_styles": null,
            "scroll_behavior": "none",
            "secondary_metabolite_radius": null,
            "semantic_zoom": null,
            "show_gene_reaction_rules": null,
            "starting_reaction": null,
            "use_3d_transform": null,
            "zoom_to_element": null
          }
        }
      }
    }
  },
  "cells": [
    {
      "cell_type": "markdown",
      "metadata": {
        "id": "view-in-github",
        "colab_type": "text"
      },
      "source": [
        "<a href=\"https://colab.research.google.com/github/SiYeon-Ju/Colab_work/blob/main/Cobrapy_OB3b_220610_fin_v10.ipynb\" target=\"_parent\"><img src=\"https://colab.research.google.com/assets/colab-badge.svg\" alt=\"Open In Colab\"/></a>"
      ]
    },
    {
      "cell_type": "code",
      "execution_count": 1,
      "metadata": {
        "colab": {
          "base_uri": "https://localhost:8080/"
        },
        "id": "0WwYsRKLM-X-",
        "outputId": "fedeeb39-21d7-44dd-dfd9-422e5ebb72e0"
      },
      "outputs": [
        {
          "output_type": "stream",
          "name": "stdout",
          "text": [
            "Looking in indexes: https://pypi.org/simple, https://us-python.pkg.dev/colab-wheels/public/simple/\n",
            "Collecting cobra==0.17.0\n",
            "  Downloading cobra-0.17.0-py2.py3-none-any.whl (1.9 MB)\n",
            "\u001b[K     |████████████████████████████████| 1.9 MB 4.8 MB/s \n",
            "\u001b[?25hCollecting depinfo\n",
            "  Downloading depinfo-2.1.1-py3-none-any.whl (23 kB)\n",
            "Collecting python-libsbml-experimental==5.18.0\n",
            "  Downloading python_libsbml_experimental-5.18.0-cp37-cp37m-manylinux1_x86_64.whl (43.9 MB)\n",
            "\u001b[K     |████████████████████████████████| 43.9 MB 3.5 MB/s \n",
            "\u001b[?25hRequirement already satisfied: six in /usr/local/lib/python3.7/dist-packages (from cobra==0.17.0) (1.15.0)\n",
            "Collecting ruamel.yaml>=0.16\n",
            "  Downloading ruamel.yaml-0.17.21-py3-none-any.whl (109 kB)\n",
            "\u001b[K     |████████████████████████████████| 109 kB 52.6 MB/s \n",
            "\u001b[?25hRequirement already satisfied: pandas>=0.17.0 in /usr/local/lib/python3.7/dist-packages (from cobra==0.17.0) (1.3.5)\n",
            "Collecting optlang>=1.4.2\n",
            "  Downloading optlang-1.5.2-py2.py3-none-any.whl (147 kB)\n",
            "\u001b[K     |████████████████████████████████| 147 kB 24.3 MB/s \n",
            "\u001b[?25hRequirement already satisfied: numpy>=1.13 in /usr/local/lib/python3.7/dist-packages (from cobra==0.17.0) (1.21.6)\n",
            "Collecting swiglpk\n",
            "  Downloading swiglpk-5.0.5-cp37-cp37m-manylinux_2_17_x86_64.manylinux2014_x86_64.whl (2.3 MB)\n",
            "\u001b[K     |████████████████████████████████| 2.3 MB 8.1 MB/s \n",
            "\u001b[?25hRequirement already satisfied: future in /usr/local/lib/python3.7/dist-packages (from cobra==0.17.0) (0.16.0)\n",
            "Requirement already satisfied: sympy>=1.0 in /usr/local/lib/python3.7/dist-packages (from optlang>=1.4.2->cobra==0.17.0) (1.7.1)\n",
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            "Requirement already satisfied: python-dateutil>=2.7.3 in /usr/local/lib/python3.7/dist-packages (from pandas>=0.17.0->cobra==0.17.0) (2.8.2)\n",
            "Collecting ruamel.yaml.clib>=0.2.6\n",
            "  Downloading ruamel.yaml.clib-0.2.6-cp37-cp37m-manylinux1_x86_64.whl (546 kB)\n",
            "\u001b[K     |████████████████████████████████| 546 kB 49.1 MB/s \n",
            "\u001b[?25hRequirement already satisfied: mpmath>=0.19 in /usr/local/lib/python3.7/dist-packages (from sympy>=1.0->optlang>=1.4.2->cobra==0.17.0) (1.2.1)\n",
            "Requirement already satisfied: importlib-metadata in /usr/local/lib/python3.7/dist-packages (from depinfo->cobra==0.17.0) (4.11.4)\n",
            "Requirement already satisfied: zipp>=0.5 in /usr/local/lib/python3.7/dist-packages (from importlib-metadata->depinfo->cobra==0.17.0) (3.8.0)\n",
            "Requirement already satisfied: typing-extensions>=3.6.4 in /usr/local/lib/python3.7/dist-packages (from importlib-metadata->depinfo->cobra==0.17.0) (4.2.0)\n",
            "Installing collected packages: swiglpk, ruamel.yaml.clib, ruamel.yaml, python-libsbml-experimental, optlang, depinfo, cobra\n",
            "Successfully installed cobra-0.17.0 depinfo-2.1.1 optlang-1.5.2 python-libsbml-experimental-5.18.0 ruamel.yaml-0.17.21 ruamel.yaml.clib-0.2.6 swiglpk-5.0.5\n"
          ]
        }
      ],
      "source": [
        "# !python --version ## 3.7 버전에서 구동 확인 ##\n",
        "!pip install cobra==0.17.0"
      ]
    },
    {
      "cell_type": "code",
      "source": [
        "!git clone https://github.com/ensakz/gem_methylosinus_trichosporium.git"
      ],
      "metadata": {
        "colab": {
          "base_uri": "https://localhost:8080/"
        },
        "id": "BCie4wAdM_og",
        "outputId": "1a8009aa-052a-4dec-b81f-4e9c287d896e"
      },
      "execution_count": 2,
      "outputs": [
        {
          "output_type": "stream",
          "name": "stdout",
          "text": [
            "Cloning into 'gem_methylosinus_trichosporium'...\n",
            "remote: Enumerating objects: 68, done.\u001b[K\n",
            "remote: Counting objects: 100% (68/68), done.\u001b[K\n",
            "remote: Compressing objects: 100% (66/66), done.\u001b[K\n",
            "remote: Total 68 (delta 13), reused 0 (delta 0), pack-reused 0\u001b[K\n",
            "Unpacking objects: 100% (68/68), done.\n"
          ]
        }
      ]
    },
    {
      "cell_type": "code",
      "source": [
        "#### Cobrapy # 0.17.0 버전 Doc\n",
        "### https://cobrapy.readthedocs.io/en/0.17.1/configuration.html\n",
        "#### Cobrapy # latest 버전 Doc\n",
        "### https://cobrapy.readthedocs.io/en/latest/index.html\n",
        "\n",
        "\n",
        "### 라이브러리 불러오기 ###\n",
        "import cobra\n",
        "import pandas as pd\n",
        "import numpy as np\n",
        "\n",
        "### 함수 추가 ###\n",
        "\n",
        "## 모델 정보 저장 ##\n",
        "# id, reaction, name, lower_bound, upper_bound, gene_reaction_rule #\n",
        "def model_info(model): \n",
        "  lst = []\n",
        "  for i in range(len(model.reactions)):\n",
        "    lst.append([model.reactions[i].id, model.reactions[i].reaction, model.reactions[i].name, \n",
        "    model.reactions[i].lower_bound, model.reactions[i].upper_bound,  model.reactions[i].gene_reaction_rule])\n",
        "  global info \n",
        "  info = pd.DataFrame( lst, columns = ['ID', 'Rxn', 'Gene_name', 'LB','UB','Gene_Rxn_Rule'] )\n",
        "  info.to_csv(str(model) + '_Model_info.csv', header = True)\n",
        "  return print('Model_info save complete!')\n",
        "\n",
        "## 모델 정보 + Flux 저장 ##\n",
        "def model_flux(model, sol): \n",
        "  lst = []\n",
        "  for i in range(len(model.reactions)):\n",
        "    lst.append([model.reactions[i].id, model.reactions[i].reaction, model.reactions[i].name, \n",
        "    model.reactions[i].lower_bound, model.reactions[i].upper_bound,  model.reactions[i].gene_reaction_rule])\n",
        "  global info \n",
        "  info = pd.DataFrame( lst, columns = ['ID', 'Rxn', 'Gene_name', 'LB','UB','Gene_Rxn_Rule'] )\n",
        "  global flux\n",
        "  flux_data = pd.DataFrame([sol.fluxes.index, sol.fluxes], index = ['ID', 'Flux']).transpose()\n",
        "  Merging_data = pd.merge(info, flux_data, on ='ID')\n",
        "  flux = Merging_data[['ID', 'Rxn', 'Flux','LB', 'UB', 'Gene_Rxn_Rule', 'Gene_name']]\n",
        "  flux.to_csv(str(model)+'_'+ str(sol) +'_Flux_results.csv', header = True)\n",
        "  return print('Model_flux save complete!')"
      ],
      "metadata": {
        "id": "RYS-3ufs19EM"
      },
      "execution_count": 3,
      "outputs": []
    },
    {
      "cell_type": "code",
      "source": [
        "## Json 모델 불러오기 ##\n",
        "model_dir = r'/content/gem_methylosinus_trichosporium/model_files/iMsOB3b.json'\n",
        "iMsOB3b = cobra.io.load_json_model(model_dir)\n",
        "\n",
        "# Bound 설정 #\n",
        "iMsOB3b.reactions.EX_ch4_e.bounds = (-14.9, 0)\n",
        "iMsOB3b.reactions.EX_no3_e.bounds = (-1000, 0)\n",
        "\n",
        "# FBA 축약본 보기 #\n",
        "iMsOB3b.summary()\n",
        "   \n",
        "# 모델 정보 저장 ('info'로 flux확인 가능)   \n",
        "model_info(iMsOB3b)"
      ],
      "metadata": {
        "id": "ZBx_kMQwNTkn",
        "colab": {
          "base_uri": "https://localhost:8080/"
        },
        "outputId": "9173f5aa-390c-4eaa-d24c-ee6c3047acb3"
      },
      "execution_count": 4,
      "outputs": [
        {
          "output_type": "stream",
          "name": "stdout",
          "text": [
            "Model_info save complete!\n"
          ]
        }
      ]
    },
    {
      "cell_type": "code",
      "source": [
        "## 모델에 새 반응식 추가하는 방법..##\n",
        "# iMsOB3b_v2 = cobra.io.load_json_model(model_dir)\n",
        "# JSY = iMsOB3b_v2.reactions.PHAS\n",
        "# JSY.id = 'JSY'\n",
        "# JSY.reaction = \"ch4_p + o2_p + qh2_c --> h2o_p + meoh_p + q_c\"\n",
        "# iMsOB3b.add_reaction(JSY)\n",
        "# model_info(iMsOB3b)\n",
        "\n",
        "\n",
        "## 아애 반응식 지우는법 ##\n",
        "# iMsOB3b.reactions.JSY.remove_from_model()\n",
        "# model_info(iMsOB3b)"
      ],
      "metadata": {
        "colab": {
          "base_uri": "https://localhost:8080/"
        },
        "id": "1DEk3QsJ-2e2",
        "outputId": "c0eb979d-6332-405c-c047-611f9576cee2"
      },
      "execution_count": null,
      "outputs": [
        {
          "output_type": "stream",
          "name": "stdout",
          "text": [
            "Model_info save complete!\n"
          ]
        }
      ]
    },
    {
      "cell_type": "code",
      "source": [
        "## 모델의 Bounds 설정 ##\n",
        "iMsOB3b.reactions.EX_ch4_e.bounds = (-14.9, 0)  ## 메탄 uptake rates\n",
        "iMsOB3b.reactions.FALDA.bounds = (0, 0)         ## THF 관련 유전자\n",
        "iMsOB3b.reactions.EX_nh4_e.bounds = (0, 0)      ## 암모니아 바운드 0\n",
        "iMsOB3b.reactions.EX_n2_e.bounds = (0, 0)       ## 질소 바운드 0\n",
        "iMsOB3b.reactions.EX_no3_e.bounds = (-1000, 0)  ## 질산 바운드 -inf ## 과제팀은 이거씀\n",
        "\n",
        "iMsOB3b.reactions.PHBD2.bounds = (0, 0) ## pbhb_c 분해 경로 제거\n",
        "\n",
        "## objective function 변경 및 확인 ##\n",
        "iMsOB3b.objective = 'PHAS'\n",
        "print('print objective:', iMsOB3b.objective.expression)\n",
        "\n",
        "## FBA 축약본 보기 ##\n",
        "iMsOB3b.summary()\n",
        "\n",
        "####### FBA analysis #########\n",
        "FBA_sol = iMsOB3b.optimize()\n",
        "#solution.fluxes\n",
        "\n",
        "## pFBA flux값 저장 ###\n",
        "model_flux(iMsOB3b, FBA_sol) #### 함수 model_flux에  Model과 Sol 넣으면 저장됨 ###"
      ],
      "metadata": {
        "id": "8hAjlbZVNPpo",
        "colab": {
          "base_uri": "https://localhost:8080/"
        },
        "outputId": "ef75ee0f-0873-4e4f-e083-52ae6cb077f8"
      },
      "execution_count": 5,
      "outputs": [
        {
          "output_type": "stream",
          "name": "stdout",
          "text": [
            "print objective: 1.0*PHAS - 1.0*PHAS_reverse_71821\n",
            "Model_flux save complete!\n"
          ]
        }
      ]
    },
    {
      "cell_type": "code",
      "source": [
        "## Parsimonas FBA 분석 ##\n",
        "pFBA_sol_ = cobra.flux_analysis.pfba(iMsOB3b,objective = 'PHAS')\n",
        "\n",
        "## pFBA flux값 저장 ###\n",
        "model_flux(iMsOB3b, pFBA_sol_)\n",
        "\n",
        "## FBA와 pFBA간에 차이 확인 ##\n",
        "print('FBA - pFBA',abs(FBA_sol.fluxes[\"PHAS\"] - pFBA_sol_.fluxes[\"PHAS\"]))"
      ],
      "metadata": {
        "id": "bixPGkHvimkU",
        "outputId": "93b33fc3-c708-42b9-81be-812f933fc92e",
        "colab": {
          "base_uri": "https://localhost:8080/"
        }
      },
      "execution_count": null,
      "outputs": [
        {
          "output_type": "stream",
          "name": "stdout",
          "text": [
            "Model_flux save complete!\n",
            "FBA - pFBA 1.1796119636642288e-16\n"
          ]
        }
      ]
    },
    {
      "cell_type": "code",
      "source": [
        "## Loopless FBA 분석 ##\n",
        "#### 아래건 이상하게 안돌아간다...####\n",
        "# from cobra.flux_analysis.loopless import add_loopless, loopless_solution\n",
        "# print('start')\n",
        "# with iMsOB3b:\n",
        "#     add_loopless(iMsOB3b)\n",
        "#     try:\n",
        "#         print(iMsOB3b.solver)\n",
        "#         solution = iMsOB3b.optimize()\n",
        "#     except:\n",
        "#         print('model is infeasible')\n",
        "# print(\"loopless solution: status = \" + solution.status)\n",
        "# print(\"loopless solution flux: v3 = %.1f\" % solution.fluxes[\"v3\"])\n",
        "\n",
        "## If there is no forced flux through a loopless reaction, parsimonious FBA will also have no flux through the loop.\n",
        "## ref) https://cobrapy.readthedocs.io/en/latest/loopless.html#Loopless-model"
      ],
      "metadata": {
        "colab": {
          "base_uri": "https://localhost:8080/"
        },
        "id": "oYTpFtoQpisD",
        "outputId": "9a87e76a-334f-46fa-eaf1-cbf01a7f0700"
      },
      "execution_count": null,
      "outputs": [
        {
          "output_type": "stream",
          "name": "stdout",
          "text": [
            "start\n"
          ]
        }
      ]
    },
    {
      "cell_type": "code",
      "source": [
        "## Loopless FBA 분석_v2 이건 돌아간다? ##\n",
        "from cobra.flux_analysis.loopless import add_loopless, loopless_solution\n",
        "add_loopless(iMsOB3b)\n",
        "loop_sol = iMsOB3b.optimize()\n",
        "\n",
        "## Loopless FBA flux값 저장 ###\n",
        "model_flux(iMsOB3b, loop_sol)"
      ],
      "metadata": {
        "id": "vTmL9MthIFmt"
      },
      "execution_count": null,
      "outputs": []
    },
    {
      "cell_type": "code",
      "source": [
        "## Moma 설정 ## #####\n",
        "## https://cobrapy.readthedocs.io/en/0.17.1/autoapi/cobra/flux_analysis/moma/index.html ##\n",
        "#sol_moma = cobra.flux_analysis.moma(iMsOB3b)\n",
        "#model_flux(iMsOB3b,sol_moma )"
      ],
      "metadata": {
        "id": "5dZ-YeHQWeH8"
      },
      "execution_count": null,
      "outputs": []
    },
    {
      "cell_type": "code",
      "source": [
        "## Essential_genes 찾기 ##\n",
        "\n",
        "# Ojective Function 하고 싶은거 설정 #\n",
        "iMsOB3b.objective = 'Biomass_Mextorquens_AM1_core'\n",
        "# iMsOB3b.objective = 'PHAS'\n",
        "\n",
        "##  Essential Gene 확인 ##\n",
        "essen_gene_list = cobra.flux_analysis.find_essential_genes(iMsOB3b)\n",
        "essen_gene_list\n",
        "\n",
        "## Essential Reaction 확인 ##\n",
        "essen_rxn_list = cobra.flux_analysis.find_essential_reactions(iMsOB3b)\n",
        "len(essen_rxn_list)\n"
      ],
      "metadata": {
        "id": "3m6AiHcrd2q7",
        "outputId": "1e22efeb-9aad-412e-e461-29a31b29ed52",
        "colab": {
          "base_uri": "https://localhost:8080/"
        }
      },
      "execution_count": null,
      "outputs": [
        {
          "output_type": "execute_result",
          "data": {
            "text/plain": [
              "852"
            ]
          },
          "metadata": {},
          "execution_count": 57
        }
      ]
    },
    {
      "cell_type": "code",
      "source": [
        "### single gene deletion 분석 ##\n",
        "### Ref) https://cobrapy.readthedocs.io/en/0.17.1/autoapi/cobra/flux_analysis/moma/index.html\n",
        "### 칼럼에 Growth라 써있지만 Objective의 Flux값을 의미하는 것으로 예상됨 - 아래 결과에서 PHAS 최대 Flux인 0.0340 값 확인 ###\n",
        "iMsOB3b.objective = 'PHAS'\n",
        "single_deletion = cobra.flux_analysis.deletion.single_reaction_deletion(iMsOB3b,\n",
        "                                                      method = 'fba',\n",
        "                                                      solution = 'moma',\n",
        "                                                      )"
      ],
      "metadata": {
        "id": "xJtOisHpgqBM",
        "outputId": "180e54f0-d635-46c2-a148-c8aff45d55e5",
        "colab": {
          "base_uri": "https://localhost:8080/",
          "height": 455
        }
      },
      "execution_count": null,
      "outputs": [
        {
          "output_type": "execute_result",
          "data": {
            "text/plain": [
              "                 growth   status\n",
              "ids                             \n",
              "(MTHFD)    2.430171e-17  optimal\n",
              "(UAGCVT)   0.000000e+00  optimal\n",
              "(UAMAGS)   0.000000e+00  optimal\n",
              "(HACD7)    3.400784e-02  optimal\n",
              "(PAPPT3)   0.000000e+00  optimal\n",
              "...                 ...      ...\n",
              "(CH4trpp)  3.400784e-02  optimal\n",
              "(HACD1)    3.400784e-02  optimal\n",
              "(PPND)     4.070938e-17  optimal\n",
              "(PMDPHT)   7.641700e-17  optimal\n",
              "(CLtex)   -6.393119e-17  optimal\n",
              "\n",
              "[1041 rows x 2 columns]"
            ],
            "text/html": [
              "\n",
              "  <div id=\"df-692d4c5f-f7e2-4f18-8212-9508f22e832d\">\n",
              "    <div class=\"colab-df-container\">\n",
              "      <div>\n",
              "<style scoped>\n",
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              "<table border=\"1\" class=\"dataframe\">\n",
              "  <thead>\n",
              "    <tr style=\"text-align: right;\">\n",
              "      <th></th>\n",
              "      <th>growth</th>\n",
              "      <th>status</th>\n",
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              "    <tr>\n",
              "      <th>ids</th>\n",
              "      <th></th>\n",
              "      <th></th>\n",
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              "  <tbody>\n",
              "    <tr>\n",
              "      <th>(MTHFD)</th>\n",
              "      <td>2.430171e-17</td>\n",
              "      <td>optimal</td>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>(UAGCVT)</th>\n",
              "      <td>0.000000e+00</td>\n",
              "      <td>optimal</td>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>(UAMAGS)</th>\n",
              "      <td>0.000000e+00</td>\n",
              "      <td>optimal</td>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>(HACD7)</th>\n",
              "      <td>3.400784e-02</td>\n",
              "      <td>optimal</td>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>(PAPPT3)</th>\n",
              "      <td>0.000000e+00</td>\n",
              "      <td>optimal</td>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>...</th>\n",
              "      <td>...</td>\n",
              "      <td>...</td>\n",
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              "    <tr>\n",
              "      <th>(CH4trpp)</th>\n",
              "      <td>3.400784e-02</td>\n",
              "      <td>optimal</td>\n",
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              "    <tr>\n",
              "      <th>(HACD1)</th>\n",
              "      <td>3.400784e-02</td>\n",
              "      <td>optimal</td>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>(PPND)</th>\n",
              "      <td>4.070938e-17</td>\n",
              "      <td>optimal</td>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>(PMDPHT)</th>\n",
              "      <td>7.641700e-17</td>\n",
              "      <td>optimal</td>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>(CLtex)</th>\n",
              "      <td>-6.393119e-17</td>\n",
              "      <td>optimal</td>\n",
              "    </tr>\n",
              "  </tbody>\n",
              "</table>\n",
              "<p>1041 rows × 2 columns</p>\n",
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              "      border-radius: 50%;\n",
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              "      display: none;\n",
              "      fill: #1967D2;\n",
              "      height: 32px;\n",
              "      padding: 0 0 0 0;\n",
              "      width: 32px;\n",
              "    }\n",
              "\n",
              "    .colab-df-convert:hover {\n",
              "      background-color: #E2EBFA;\n",
              "      box-shadow: 0px 1px 2px rgba(60, 64, 67, 0.3), 0px 1px 3px 1px rgba(60, 64, 67, 0.15);\n",
              "      fill: #174EA6;\n",
              "    }\n",
              "\n",
              "    [theme=dark] .colab-df-convert {\n",
              "      background-color: #3B4455;\n",
              "      fill: #D2E3FC;\n",
              "    }\n",
              "\n",
              "    [theme=dark] .colab-df-convert:hover {\n",
              "      background-color: #434B5C;\n",
              "      box-shadow: 0px 1px 3px 1px rgba(0, 0, 0, 0.15);\n",
              "      filter: drop-shadow(0px 1px 2px rgba(0, 0, 0, 0.3));\n",
              "      fill: #FFFFFF;\n",
              "    }\n",
              "  </style>\n",
              "\n",
              "      <script>\n",
              "        const buttonEl =\n",
              "          document.querySelector('#df-692d4c5f-f7e2-4f18-8212-9508f22e832d button.colab-df-convert');\n",
              "        buttonEl.style.display =\n",
              "          google.colab.kernel.accessAllowed ? 'block' : 'none';\n",
              "\n",
              "        async function convertToInteractive(key) {\n",
              "          const element = document.querySelector('#df-692d4c5f-f7e2-4f18-8212-9508f22e832d');\n",
              "          const dataTable =\n",
              "            await google.colab.kernel.invokeFunction('convertToInteractive',\n",
              "                                                     [key], {});\n",
              "          if (!dataTable) return;\n",
              "\n",
              "          const docLinkHtml = 'Like what you see? Visit the ' +\n",
              "            '<a target=\"_blank\" href=https://colab.research.google.com/notebooks/data_table.ipynb>data table notebook</a>'\n",
              "            + ' to learn more about interactive tables.';\n",
              "          element.innerHTML = '';\n",
              "          dataTable['output_type'] = 'display_data';\n",
              "          await google.colab.output.renderOutput(dataTable, element);\n",
              "          const docLink = document.createElement('div');\n",
              "          docLink.innerHTML = docLinkHtml;\n",
              "          element.appendChild(docLink);\n",
              "        }\n",
              "      </script>\n",
              "    </div>\n",
              "  </div>\n",
              "  "
            ]
          },
          "metadata": {},
          "execution_count": 7
        }
      ]
    },
    {
      "cell_type": "code",
      "source": [
        "### Robust Analysis?? ###\n",
        "results_rb = cobra.flux_analysis.phenotype_phase_plane.production_envelope(iMsOB3b, \n",
        "                                                              reactions =['Biomass_Mextorquens_AM1_core' ,'PPND'], \n",
        "                                                              objective = 'PHAS',\n",
        "                                                              carbon_sources = 'EX_ch4_e', \n",
        "                                                              points = 20)\n",
        "results_rb"
      ],
      "metadata": {
        "colab": {
          "base_uri": "https://localhost:8080/",
          "height": 488
        },
        "id": "FLsvK7MCkRDD",
        "outputId": "0a8343e9-d020-444f-c396-4d5875657c5d"
      },
      "execution_count": null,
      "outputs": [
        {
          "output_type": "execute_result",
          "data": {
            "text/plain": [
              "    carbon_source  flux_minimum  carbon_yield_minimum  mass_yield_minimum  \\\n",
              "0        EX_ch4_e      0.000000                   0.0                 NaN   \n",
              "1        EX_ch4_e           NaN                   NaN                 NaN   \n",
              "2        EX_ch4_e           NaN                   NaN                 NaN   \n",
              "3        EX_ch4_e           NaN                   NaN                 NaN   \n",
              "4        EX_ch4_e           NaN                   NaN                 NaN   \n",
              "..            ...           ...                   ...                 ...   \n",
              "395      EX_ch4_e           NaN                   NaN                 NaN   \n",
              "396      EX_ch4_e           NaN                   NaN                 NaN   \n",
              "397      EX_ch4_e           NaN                   NaN                 NaN   \n",
              "398      EX_ch4_e           NaN                   NaN                 NaN   \n",
              "399      EX_ch4_e      0.034008                   0.0                 NaN   \n",
              "\n",
              "     flux_maximum  carbon_yield_maximum  mass_yield_maximum  \\\n",
              "0        0.000000                   0.0                 NaN   \n",
              "1             NaN                   NaN                 NaN   \n",
              "2             NaN                   NaN                 NaN   \n",
              "3             NaN                   NaN                 NaN   \n",
              "4             NaN                   NaN                 NaN   \n",
              "..            ...                   ...                 ...   \n",
              "395           NaN                   NaN                 NaN   \n",
              "396           NaN                   NaN                 NaN   \n",
              "397           NaN                   NaN                 NaN   \n",
              "398           NaN                   NaN                 NaN   \n",
              "399      0.034008                   0.0                 NaN   \n",
              "\n",
              "     Biomass_Mextorquens_AM1_core      PPND  \n",
              "0                        0.000000  0.000000  \n",
              "1                        0.000000  0.000489  \n",
              "2                        0.000000  0.000977  \n",
              "3                        0.000000  0.001466  \n",
              "4                        0.000000  0.001954  \n",
              "..                            ...       ...  \n",
              "395                      0.122604  0.007328  \n",
              "396                      0.122604  0.007816  \n",
              "397                      0.122604  0.008305  \n",
              "398                      0.122604  0.008793  \n",
              "399                      0.122604  0.009282  \n",
              "\n",
              "[400 rows x 9 columns]"
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              "\n",
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              "      <div>\n",
              "<style scoped>\n",
              "    .dataframe tbody tr th:only-of-type {\n",
              "        vertical-align: middle;\n",
              "    }\n",
              "\n",
              "    .dataframe tbody tr th {\n",
              "        vertical-align: top;\n",
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              "\n",
              "    .dataframe thead th {\n",
              "        text-align: right;\n",
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              "</style>\n",
              "<table border=\"1\" class=\"dataframe\">\n",
              "  <thead>\n",
              "    <tr style=\"text-align: right;\">\n",
              "      <th></th>\n",
              "      <th>carbon_source</th>\n",
              "      <th>flux_minimum</th>\n",
              "      <th>carbon_yield_minimum</th>\n",
              "      <th>mass_yield_minimum</th>\n",
              "      <th>flux_maximum</th>\n",
              "      <th>carbon_yield_maximum</th>\n",
              "      <th>mass_yield_maximum</th>\n",
              "      <th>Biomass_Mextorquens_AM1_core</th>\n",
              "      <th>PPND</th>\n",
              "    </tr>\n",
              "  </thead>\n",
              "  <tbody>\n",
              "    <tr>\n",
              "      <th>0</th>\n",
              "      <td>EX_ch4_e</td>\n",
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              "      <td>0.000000</td>\n",
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              "    <tr>\n",
              "      <th>1</th>\n",
              "      <td>EX_ch4_e</td>\n",
              "      <td>NaN</td>\n",
              "      <td>NaN</td>\n",
              "      <td>NaN</td>\n",
              "      <td>NaN</td>\n",
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              "      <td>0.000000</td>\n",
              "      <td>0.000489</td>\n",
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              "    <tr>\n",
              "      <th>2</th>\n",
              "      <td>EX_ch4_e</td>\n",
              "      <td>NaN</td>\n",
              "      <td>NaN</td>\n",
              "      <td>NaN</td>\n",
              "      <td>NaN</td>\n",
              "      <td>NaN</td>\n",
              "      <td>NaN</td>\n",
              "      <td>0.000000</td>\n",
              "      <td>0.000977</td>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>3</th>\n",
              "      <td>EX_ch4_e</td>\n",
              "      <td>NaN</td>\n",
              "      <td>NaN</td>\n",
              "      <td>NaN</td>\n",
              "      <td>NaN</td>\n",
              "      <td>NaN</td>\n",
              "      <td>NaN</td>\n",
              "      <td>0.000000</td>\n",
              "      <td>0.001466</td>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>4</th>\n",
              "      <td>EX_ch4_e</td>\n",
              "      <td>NaN</td>\n",
              "      <td>NaN</td>\n",
              "      <td>NaN</td>\n",
              "      <td>NaN</td>\n",
              "      <td>NaN</td>\n",
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              "      <td>0.000000</td>\n",
              "      <td>0.001954</td>\n",
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              "    <tr>\n",
              "      <th>...</th>\n",
              "      <td>...</td>\n",
              "      <td>...</td>\n",
              "      <td>...</td>\n",
              "      <td>...</td>\n",
              "      <td>...</td>\n",
              "      <td>...</td>\n",
              "      <td>...</td>\n",
              "      <td>...</td>\n",
              "      <td>...</td>\n",
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              "    <tr>\n",
              "      <th>395</th>\n",
              "      <td>EX_ch4_e</td>\n",
              "      <td>NaN</td>\n",
              "      <td>NaN</td>\n",
              "      <td>NaN</td>\n",
              "      <td>NaN</td>\n",
              "      <td>NaN</td>\n",
              "      <td>NaN</td>\n",
              "      <td>0.122604</td>\n",
              "      <td>0.007328</td>\n",
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              "    <tr>\n",
              "      <th>396</th>\n",
              "      <td>EX_ch4_e</td>\n",
              "      <td>NaN</td>\n",
              "      <td>NaN</td>\n",
              "      <td>NaN</td>\n",
              "      <td>NaN</td>\n",
              "      <td>NaN</td>\n",
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              "    <tr>\n",
              "      <th>397</th>\n",
              "      <td>EX_ch4_e</td>\n",
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              "    <tr>\n",
              "      <th>398</th>\n",
              "      <td>EX_ch4_e</td>\n",
              "      <td>NaN</td>\n",
              "      <td>NaN</td>\n",
              "      <td>NaN</td>\n",
              "      <td>NaN</td>\n",
              "      <td>NaN</td>\n",
              "      <td>NaN</td>\n",
              "      <td>0.122604</td>\n",
              "      <td>0.008793</td>\n",
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              "    <tr>\n",
              "      <th>399</th>\n",
              "      <td>EX_ch4_e</td>\n",
              "      <td>0.034008</td>\n",
              "      <td>0.0</td>\n",
              "      <td>NaN</td>\n",
              "      <td>0.034008</td>\n",
              "      <td>0.0</td>\n",
              "      <td>NaN</td>\n",
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              "  </tbody>\n",
              "</table>\n",
              "<p>400 rows × 9 columns</p>\n",
              "</div>\n",
              "      <button class=\"colab-df-convert\" onclick=\"convertToInteractive('df-ab187917-0708-4e69-87f4-aa606d87e1e3')\"\n",
              "              title=\"Convert this dataframe to an interactive table.\"\n",
              "              style=\"display:none;\">\n",
              "        \n",
              "  <svg xmlns=\"http://www.w3.org/2000/svg\" height=\"24px\"viewBox=\"0 0 24 24\"\n",
              "       width=\"24px\">\n",
              "    <path d=\"M0 0h24v24H0V0z\" fill=\"none\"/>\n",
              "    <path d=\"M18.56 5.44l.94 2.06.94-2.06 2.06-.94-2.06-.94-.94-2.06-.94 2.06-2.06.94zm-11 1L8.5 8.5l.94-2.06 2.06-.94-2.06-.94L8.5 2.5l-.94 2.06-2.06.94zm10 10l.94 2.06.94-2.06 2.06-.94-2.06-.94-.94-2.06-.94 2.06-2.06.94z\"/><path d=\"M17.41 7.96l-1.37-1.37c-.4-.4-.92-.59-1.43-.59-.52 0-1.04.2-1.43.59L10.3 9.45l-7.72 7.72c-.78.78-.78 2.05 0 2.83L4 21.41c.39.39.9.59 1.41.59.51 0 1.02-.2 1.41-.59l7.78-7.78 2.81-2.81c.8-.78.8-2.07 0-2.86zM5.41 20L4 18.59l7.72-7.72 1.47 1.35L5.41 20z\"/>\n",
              "  </svg>\n",
              "      </button>\n",
              "      \n",
              "  <style>\n",
              "    .colab-df-container {\n",
              "      display:flex;\n",
              "      flex-wrap:wrap;\n",
              "      gap: 12px;\n",
              "    }\n",
              "\n",
              "    .colab-df-convert {\n",
              "      background-color: #E8F0FE;\n",
              "      border: none;\n",
              "      border-radius: 50%;\n",
              "      cursor: pointer;\n",
              "      display: none;\n",
              "      fill: #1967D2;\n",
              "      height: 32px;\n",
              "      padding: 0 0 0 0;\n",
              "      width: 32px;\n",
              "    }\n",
              "\n",
              "    .colab-df-convert:hover {\n",
              "      background-color: #E2EBFA;\n",
              "      box-shadow: 0px 1px 2px rgba(60, 64, 67, 0.3), 0px 1px 3px 1px rgba(60, 64, 67, 0.15);\n",
              "      fill: #174EA6;\n",
              "    }\n",
              "\n",
              "    [theme=dark] .colab-df-convert {\n",
              "      background-color: #3B4455;\n",
              "      fill: #D2E3FC;\n",
              "    }\n",
              "\n",
              "    [theme=dark] .colab-df-convert:hover {\n",
              "      background-color: #434B5C;\n",
              "      box-shadow: 0px 1px 3px 1px rgba(0, 0, 0, 0.15);\n",
              "      filter: drop-shadow(0px 1px 2px rgba(0, 0, 0, 0.3));\n",
              "      fill: #FFFFFF;\n",
              "    }\n",
              "  </style>\n",
              "\n",
              "      <script>\n",
              "        const buttonEl =\n",
              "          document.querySelector('#df-ab187917-0708-4e69-87f4-aa606d87e1e3 button.colab-df-convert');\n",
              "        buttonEl.style.display =\n",
              "          google.colab.kernel.accessAllowed ? 'block' : 'none';\n",
              "\n",
              "        async function convertToInteractive(key) {\n",
              "          const element = document.querySelector('#df-ab187917-0708-4e69-87f4-aa606d87e1e3');\n",
              "          const dataTable =\n",
              "            await google.colab.kernel.invokeFunction('convertToInteractive',\n",
              "                                                     [key], {});\n",
              "          if (!dataTable) return;\n",
              "\n",
              "          const docLinkHtml = 'Like what you see? Visit the ' +\n",
              "            '<a target=\"_blank\" href=https://colab.research.google.com/notebooks/data_table.ipynb>data table notebook</a>'\n",
              "            + ' to learn more about interactive tables.';\n",
              "          element.innerHTML = '';\n",
              "          dataTable['output_type'] = 'display_data';\n",
              "          await google.colab.output.renderOutput(dataTable, element);\n",
              "          const docLink = document.createElement('div');\n",
              "          docLink.innerHTML = docLinkHtml;\n",
              "          element.appendChild(docLink);\n",
              "        }\n",
              "      </script>\n",
              "    </div>\n",
              "  </div>\n",
              "  "
            ]
          },
          "metadata": {},
          "execution_count": 9
        }
      ]
    },
    {
      "cell_type": "code",
      "source": [
        "## optgene, optknock 돌리기 위한 Tool 설치##\n",
        "!pip install cameo "
      ],
      "metadata": {
        "colab": {
          "base_uri": "https://localhost:8080/"
        },
        "id": "4SvqiFmIpZ58",
        "outputId": "06262b4a-57b7-45fc-e908-8144c6aaad7e"
      },
      "execution_count": 6,
      "outputs": [
        {
          "output_type": "stream",
          "name": "stdout",
          "text": [
            "Looking in indexes: https://pypi.org/simple, https://us-python.pkg.dev/colab-wheels/public/simple/\n",
            "Collecting cameo\n",
            "  Downloading cameo-0.13.6-py2.py3-none-any.whl (13.9 MB)\n",
            "\u001b[K     |████████████████████████████████| 13.9 MB 5.1 MB/s \n",
            "\u001b[?25hCollecting lazy-object-proxy>=1.2.0\n",
            "  Downloading lazy_object_proxy-1.7.1-cp37-cp37m-manylinux_2_5_x86_64.manylinux1_x86_64.manylinux_2_17_x86_64.manylinux2014_x86_64.whl (57 kB)\n",
            "\u001b[K     |████████████████████████████████| 57 kB 4.2 MB/s \n",
            "\u001b[?25hRequirement already satisfied: optlang>=1.4.2 in /usr/local/lib/python3.7/dist-packages (from cameo) (1.5.2)\n",
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            "  Downloading gnomic-1.0.1.tar.gz (13 kB)\n",
            "Requirement already satisfied: networkx>=2.4 in /usr/local/lib/python3.7/dist-packages (from cameo) (2.6.3)\n",
            "Collecting ordered-set>=1.2\n",
            "  Downloading ordered_set-4.1.0-py3-none-any.whl (7.6 kB)\n",
            "Collecting escher>=1.1.2\n",
            "  Downloading Escher-1.7.3-py3-none-any.whl (1.2 MB)\n",
            "\u001b[K     |████████████████████████████████| 1.2 MB 55.0 MB/s \n",
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            "Collecting blessings>=1.5.1\n",
            "  Downloading blessings-1.7-py3-none-any.whl (18 kB)\n",
            "Collecting grako==3.18.1\n",
            "  Downloading grako-3.18.1-py2.py3-none-any.whl (76 kB)\n",
            "\u001b[K     |████████████████████████████████| 76 kB 4.7 MB/s \n",
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            "Building wheels for collected packages: gnomic\n",
            "  Building wheel for gnomic (setup.py) ... \u001b[?25l\u001b[?25hdone\n",
            "  Created wheel for gnomic: filename=gnomic-1.0.1-py3-none-any.whl size=14671 sha256=cfb1672cd8ea2272f53fc6c8055698e9d6d324f7d101d3b12ad7e77f77eef244\n",
            "  Stored in directory: /root/.cache/pip/wheels/78/c5/31/10f917cc1ca63da8ca323fb2f79aa37d0cc75211561beb9d4c\n",
            "Successfully built gnomic\n",
            "Installing collected packages: jsonschema, pluggy, pytest, grako, ordered-set, lazy-object-proxy, IProgress, inspyred, gnomic, escher, blessings, cameo\n",
            "  Attempting uninstall: jsonschema\n",
            "    Found existing installation: jsonschema 4.3.3\n",
            "    Uninstalling jsonschema-4.3.3:\n",
            "      Successfully uninstalled jsonschema-4.3.3\n",
            "  Attempting uninstall: pluggy\n",
            "    Found existing installation: pluggy 0.7.1\n",
            "    Uninstalling pluggy-0.7.1:\n",
            "      Successfully uninstalled pluggy-0.7.1\n",
            "  Attempting uninstall: pytest\n",
            "    Found existing installation: pytest 3.6.4\n",
            "    Uninstalling pytest-3.6.4:\n",
            "      Successfully uninstalled pytest-3.6.4\n",
            "\u001b[31mERROR: pip's dependency resolver does not currently take into account all the packages that are installed. This behaviour is the source of the following dependency conflicts.\n",
            "nbclient 0.6.4 requires jupyter-client>=6.1.5, but you have jupyter-client 5.3.5 which is incompatible.\n",
            "nbclient 0.6.4 requires traitlets>=5.2.2, but you have traitlets 5.1.1 which is incompatible.\n",
            "datascience 0.10.6 requires folium==0.2.1, but you have folium 0.8.3 which is incompatible.\u001b[0m\n",
            "Successfully installed IProgress-0.4 blessings-1.7 cameo-0.13.6 escher-1.7.3 gnomic-1.0.1 grako-3.18.1 inspyred-1.0.1 jsonschema-3.2.0 lazy-object-proxy-1.7.1 ordered-set-4.1.0 pluggy-0.13.1 pytest-4.6.11\n"
          ]
        }
      ]
    },
    {
      "cell_type": "code",
      "source": [
        "## Optgene ## A Methond using evolutionary algorithms\n",
        "from cameo.strain_design import OptGene\n",
        "optgene = OptGene(iMsOB3b)\n",
        "\n",
        "result = optgene.run(target=iMsOB3b.reactions.PHAS,\n",
        "                     biomass=iMsOB3b.reactions.Biomass_Mextorquens_AM1_core,\n",
        "                     substrate=iMsOB3b.metabolites.ch4_e, ## EX_ch4_e ###\n",
        "                     max_evaluations=5000,\n",
        "                     plot=False)\n",
        "result"
      ],
      "metadata": {
        "colab": {
          "base_uri": "https://localhost:8080/",
          "height": 220,
          "referenced_widgets": [
            "863c5c511e4e45cbb6d2e89bb0ed5e41",
            "0450644db06c4cd0b44286cce157a665",
            "889100582d444508a2079fa180b8054a",
            "2d1062eaa78341308713bf9cae72583d",
            "9a5e1b5fdd2e46e1ae15ae38f139f985",
            "3f571eed0bc3408680d1f5d2432bf911",
            "d8b20f136bbc49ab804526797edd8289",
            "cd499a1ee41043908a5178f85a1e7da8",
            "15a38c9cb0f24bfcbe6d26e371fdd1ff",
            "d09142b0d8e74cc5b3f6a0a22b4065b2",
            "ecc7531656c94b539c352665745ea7d1"
          ]
        },
        "id": "lEKUpoZ9pk0r",
        "outputId": "213d44a1-78e8-4281-c589-880ec42e995b"
      },
      "execution_count": null,
      "outputs": [
        {
          "output_type": "stream",
          "name": "stdout",
          "text": [
            "Starting optimization at Thu, 09 Jun 2022 18:10:09\n"
          ]
        },
        {
          "output_type": "display_data",
          "data": {
            "text/plain": [
              "HBox()"
            ],
            "application/vnd.jupyter.widget-view+json": {
              "version_major": 2,
              "version_minor": 0,
              "model_id": "863c5c511e4e45cbb6d2e89bb0ed5e41"
            }
          },
          "metadata": {}
        },
        {
          "output_type": "stream",
          "name": "stdout",
          "text": [
            "Finished after 00:04:54\n"
          ]
        },
        {
          "output_type": "stream",
          "name": "stderr",
          "text": [
            "No solutions found\n"
          ]
        },
        {
          "output_type": "execute_result",
          "data": {
            "text/plain": [
              "<cameo.strain_design.heuristic.evolutionary_based.OptGeneResult at 0x7f86f865eb10>"
            ],
            "text/html": [
              "\n",
              "        <h3>OptGene Result</h3>\n",
              "        <ul>\n",
              "            <li>Simulation: fba<br/></li>\n",
              "            <li>Objective Function: $$bpcy = \\frac{(Biomass\\_Mextorquens\\_AM1\\_core * PHAS)}{EX\\_ch4\\_e}$$<br/></li>\n",
              "        </ul>\n",
              "        <div>\n",
              "<style scoped>\n",
              "    .dataframe tbody tr th:only-of-type {\n",
              "        vertical-align: middle;\n",
              "    }\n",
              "\n",
              "    .dataframe tbody tr th {\n",
              "        vertical-align: top;\n",
              "    }\n",
              "\n",
              "    .dataframe thead th {\n",
              "        text-align: right;\n",
              "    }\n",
              "</style>\n",
              "<table border=\"1\" class=\"dataframe\">\n",
              "  <thead>\n",
              "    <tr style=\"text-align: right;\">\n",
              "      <th></th>\n",
              "      <th>reactions</th>\n",
              "      <th>genes</th>\n",
              "      <th>size</th>\n",
              "      <th>fva_min</th>\n",
              "      <th>fva_max</th>\n",
              "      <th>target_flux</th>\n",
              "      <th>biomass_flux</th>\n",
              "      <th>yield</th>\n",
              "      <th>fitness</th>\n",
              "    </tr>\n",
              "  </thead>\n",
              "  <tbody>\n",
              "  </tbody>\n",
              "</table>\n",
              "</div>\n",
              "        "
            ]
          },
          "metadata": {},
          "execution_count": 14
        }
      ]
    },
    {
      "cell_type": "code",
      "source": [
        "## OptKnock ## A method using linear programming ###\n",
        "from cameo.strain_design import OptKnock\n",
        "optknock = OptKnock(iMsOB3b, fraction_of_optimum=0.1)\n",
        "\n",
        "result = optknock.run(max_knockouts=2,\n",
        "                     target=iMsOB3b.reactions.PHAS,\n",
        "                     biomass=iMsOB3b.reactions.Biomass_Mextorquens_AM1_core,\n",
        "                    # substrate=iMsOB3b.metabolites.ch4_e, ## EX_ch4_e ###\n",
        "                     #max_evaluations=5000,\n",
        "                     #plot=False,\n",
        "                      )\n",
        "result"
      ],
      "metadata": {
        "colab": {
          "base_uri": "https://localhost:8080/",
          "height": 217,
          "referenced_widgets": [
            "8b0a7fd2817b4bd696188950aa47acc3",
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            "89b744d0c422418194d4be825e3b6383",
            "cd97fd15aa0042ab9eaed54287458cfe",
            "d574cb9df44a450b9986097bb37633b3",
            "7384b7ae4c0840699afa9f03e076fe1f",
            "ff91d8b005a545b8a9a7bac0aecf8e85",
            "c262ea90c1044fd186dd70fd78d067a8",
            "e40a00623e5543e3b4bdc971b2585e96",
            "1cb22b66f33b49c297617a0a2e287f97"
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        },
        "id": "SCvMKaDjqgoT",
        "outputId": "5c46b400-74ee-46bd-d1c4-9a547c458d8d"
      },
      "execution_count": null,
      "outputs": [
        {
          "output_type": "stream",
          "name": "stderr",
          "text": [
            "/usr/local/lib/python3.7/dist-packages/cameo/strain_design/deterministic/linear_programming.py:119 \u001b[1;31mUserWarning\u001b[0m: You are trying to run OptKnock with glpk_interface. This might not end well.\n"
          ]
        },
        {
          "output_type": "display_data",
          "data": {
            "text/plain": [
              "HBox()"
            ],
            "application/vnd.jupyter.widget-view+json": {
              "version_major": 2,
              "version_minor": 0,
              "model_id": "8b0a7fd2817b4bd696188950aa47acc3"
            }
          },
          "metadata": {}
        },
        {
          "output_type": "execute_result",
          "data": {
            "text/plain": [
              "<cameo.strain_design.deterministic.linear_programming.OptKnockResult at 0x7f86f338af90>"
            ],
            "text/html": [
              "\n",
              "        <h3>OptKnock:</h3>\n",
              "        <ul>\n",
              "            <li>Target: PHAS</li>\n",
              "        </ul>\n",
              "        <div>\n",
              "<style scoped>\n",
              "    .dataframe tbody tr th:only-of-type {\n",
              "        vertical-align: middle;\n",
              "    }\n",
              "\n",
              "    .dataframe tbody tr th {\n",
              "        vertical-align: top;\n",
              "    }\n",
              "\n",
              "    .dataframe thead th {\n",
              "        text-align: right;\n",
              "    }\n",
              "</style>\n",
              "<table border=\"1\" class=\"dataframe\">\n",
              "  <thead>\n",
              "    <tr style=\"text-align: right;\">\n",
              "      <th></th>\n",
              "      <th>reactions</th>\n",
              "      <th>size</th>\n",
              "      <th>PHAS</th>\n",
              "      <th>biomass</th>\n",
              "      <th>fva_min</th>\n",
              "      <th>fva_max</th>\n",
              "    </tr>\n",
              "  </thead>\n",
              "  <tbody>\n",
              "    <tr>\n",
              "      <th>0</th>\n",
              "      <td>{NTPP7, CYOD}</td>\n",
              "      <td>2</td>\n",
              "      <td>0.034008</td>\n",
              "      <td>0.122604</td>\n",
              "      <td>0.033668</td>\n",
              "      <td>0.034008</td>\n",
              "    </tr>\n",
              "  </tbody>\n",
              "</table>\n",
              "</div>"
            ]
          },
          "metadata": {},
          "execution_count": 17
        }
      ]
    },
    {
      "cell_type": "code",
      "source": [
        "############# 기본 입력 방식 ####################\n",
        "## 특정 반응식(PPND) 확인\n",
        "# iMsOB3b.reactions.PPND.reaction\n",
        "\n",
        "## 특정 반응식(PPND) 변경\n",
        "# iMsOB3b.reactions.PPND.reaction = \"ch4_p + o2_p + qh2_c --> h2o_p + meoh_p + q_c\"\n",
        "## 처음 넣는 대사체로 변경할 경우, unknown metabolite \"xx\" created 라는 말이 뜬다\n",
        "\n",
        "## 특정 대사물질(q_c)이 포함된 반응식을 모두 뽑아내는 방법 ###\n",
        "# for reaction in iMsOB3b.metabolites.q_c.reactions:\n",
        "#     print(reaction.name, reaction)\n",
        "\n",
        "## 반응식에 대사체 추가하기 ##\n",
        "# iMsOB3b.reactions.PPND.add_metabolites({model.metabolites.get_by_id(\"h_c\"): -1})\n",
        "# iMsOB3b.reactions.PPND.reaction\n",
        "\n",
        "\n",
        "## bound 확인##\n",
        "# iMsOB3b.reactions.PGI.lower_bound,  iMsOB3b.reactions.PGI.upper_bound\n",
        "## bound 변경##\n",
        "# pgi.bounds = (0, 1000.0)\n",
        "\n",
        "## deletion 처리할때\n",
        "# AM1_bigg.reactions.PMMODCipp.knock_out()\n",
        "\n",
        "\n",
        "## 특정 Reaction 뽑아낼 때, list comprehension 사용 ##\n",
        "# qh2_c_consuming = [rxn for rxn in model_OB3b.metabolites.qh2_c.reactions if rxn.reversibility or model_OB3b.metabolites.qh2_c in rxn.reactants]\n",
        "\n",
        "## 모델 Reaction에서 특정 단어가 들어간걸 찾을 떄 쓰는 방식.. ##\n",
        "# import re\n",
        "# for reaction in iMsOB3b.reactions:\n",
        "#     if re.search(\"translocatin\", reaction.name, re.IGNORECASE):\n",
        "#         print(reaction.id, reaction.name)"
      ],
      "metadata": {
        "id": "5yq-pLYhbDqE",
        "outputId": "9f1790f6-edfa-441a-8f9c-ce3cd3088ed1",
        "colab": {
          "base_uri": "https://localhost:8080/"
        }
      },
      "execution_count": null,
      "outputs": [
        {
          "output_type": "stream",
          "name": "stdout",
          "text": [
            "NADH ubiquinone oxidoreductase I NADH11: 5.0 h_c + nadh_c + q_c --> 4.0 h_p + nad_c + qh2_c\n",
            "succinate dehydrogenase SUCCD1: q_c + succ_c <=> fum_c + qh2_c\n",
            "QRr QRr: h_c + nadph_c + q_c --> nadp_c + qh2_c\n",
            "Nitrate reductase (Ubiquinol-8) NO3R1: no3_c + qh2_c --> h2o_c + no2_c + q_c\n",
            "ETF dehydrogenase ETFDH: q_c + rETF_c <=> oxETF_c + qh2_c\n",
            "particulate Methane Monooxygenase PMMOipp: ch4_p + o2_p + qh2_c --> h2o_p + meoh_p + q_c\n",
            "particulate ammonia monooxygenase PAMMOipp: nh4_p + o2_p + qh2_c --> h2o_p + h_p + ham_p + q_c\n",
            "ubiquinol cytochrome c reductase UQCYOR_2p: 2.0 ficytc_c + qh2_c --> 2.0 focytc_c + 2.0 h_p + q_c\n",
            "cytochrome bd ubiquinol oxidase CYOD: 4.0 h_c + o2_c + 2.0 qh2_c --> 2.0 h2o_c + 4.0 h_p + 2.0 q_c\n",
            "cytochrome o ubiquinol oxidase CYOO_4p: 4.0 h_c + 0.5 o2_c + qh2_c --> h2o_c + 4.0 h_p + q_c\n",
            "photosystem I cyclic PHOTOSYS1C: 2.0 fdxrd_c + 2.0 h_c + q_c --> 2.0 fdxox_c + qh2_c\n",
            "NADPH Quinone Reductase (Ubiquinone-8) NADPHQR2: h_c + nadph_c + q_c --> nadp_c + qh2_c\n"
          ]
        },
        {
          "output_type": "execute_result",
          "data": {
            "text/plain": [
              "(-1000.0, 1000.0)"
            ]
          },
          "metadata": {},
          "execution_count": 9
        }
      ]
    },
    {
      "cell_type": "code",
      "source": [
        "## 모델에 새로운 Reaction 추가하기 ##\n",
        "#####\n",
        "# Step 1) 타? 모델에 있는 rxn을 가져오기...?\n",
        "# iMsOB3b_adapted_reactions = [iMsOB3b.reactions.SAMMOi, iMsOB3b.reactions.NO3t7pp, iMsOB3b.reactions.NO3R1, \n",
        "#                              iMsOB3b.reactions.NITR_NOpp, iMsOB3b.reactions.NITR_AMpp, \n",
        "#                              iMsOB3b.reactions.NTRIR2y, iMsOB3b.reactions.NTRIR2x]\n",
        "\n",
        "# Step 2) 쓸 모델에 add하기...  add_reaction은  Cobra.core.reaction인가? 이 포멧만 넣을 수 있음.. (출처 논문..)\n",
        "# for reaction in iMsOB3b_adapted_reactions:\n",
        "#     model_OB3b.add_reaction(reaction)\n",
        "    \n",
        "# Step 3) 그리고 reaction 식 바꾸기.. 아래처럼..\n",
        "# model_OB3b.reactions.SAMMOi.reaction = \"ch4_p + o2_p + qh2_c --> h2o_p + meoh_p + q_c\""
      ],
      "metadata": {
        "id": "kOKFv_oYN-X_"
      },
      "execution_count": null,
      "outputs": []
    },
    {
      "cell_type": "code",
      "source": [
        "## 원랜 신규 Reaciton 만드는 방법은 아래와 같다.... 복잡... ##\n",
        "from cobra import Model, Reaction, Metabolite\n",
        "\n",
        "reaction = Reaction('R_3OAS140')\n",
        "reaction.name = '3 oxoacyl acyl carrier protein synthase n C140 '\n",
        "reaction.subsystem = 'Cell Envelope Biosynthesis'\n",
        "reaction.lower_bound = 0.  # This is the default\n",
        "reaction.upper_bound = 1000.  # This is the default\n",
        "\n",
        "ACP_c = Metabolite(\n",
        "    'ACP_c',\n",
        "    formula='C11H21N2O7PRS',\n",
        "    name='acyl-carrier-protein',\n",
        "    compartment='c')\n",
        "omrsACP_c = Metabolite(\n",
        "    'M3omrsACP_c',\n",
        "    formula='C25H45N2O9PRS',\n",
        "    name='3-Oxotetradecanoyl-acyl-carrier-protein',\n",
        "    compartment='c')\n",
        "co2_c = Metabolite('co2_c', formula='CO2', name='CO2', compartment='c')\n",
        "malACP_c = Metabolite(\n",
        "    'malACP_c',\n",
        "    formula='C14H22N2O10PRS',\n",
        "    name='Malonyl-acyl-carrier-protein',\n",
        "    compartment='c')\n",
        "h_c = Metabolite('h_c', formula='H', name='H', compartment='c')\n",
        "ddcaACP_c = Metabolite(\n",
        "    'ddcaACP_c',\n",
        "    formula='C23H43N2O8PRS',\n",
        "    name='Dodecanoyl-ACP-n-C120ACP',\n",
        "    compartment='c')\n",
        "\n",
        "\n",
        "\n",
        "reaction.add_metabolites({\n",
        "    malACP_c: -1.0,\n",
        "    h_c: -1.0,\n",
        "    ddcaACP_c: -1.0,\n",
        "    co2_c: 1.0,\n",
        "    ACP_c: 1.0,\n",
        "    omrsACP_c: 1.0\n",
        "})\n",
        "\n",
        "\n",
        "reaction.gene_reaction_rule = '( STM2378 or STM1197 )'\n",
        "\n",
        "\n",
        "### 간단 추가 버전 ##\n",
        "from cobra import Model, Reaction, Metabolite\n",
        "# Best practise: SBML compliant IDs\n",
        "\n",
        "reaction = Reaction('PFK')\n",
        "reaction.name = 'Phosphofructokinase'\n",
        "reaction.lower_bound = -1000.  # This is the default\n",
        "reaction.upper_bound = 1000.  # This is the default\n",
        "\n",
        "iMsOB3b.add_reaction(reaction)\n",
        "iMsOB3b.reactions.PFK.reaction = 'atp_c + f6p_c <=> adp_c + fdp_c + h_c'\n",
        "iMsOB3b.reactions.FDHr.gene_reaction_rule = 'CQW49_16615 and CQW49_16630 and (CQW49_16625 or CQW49_16125) and CQW49_16635'"
      ],
      "metadata": {
        "id": "ntXrxFedI6pW"
      },
      "execution_count": null,
      "outputs": []
    },
    {
      "cell_type": "code",
      "source": [
        "### KEGG 적용 ###\n",
        "import orangecontrib.bioinformatics.kegg\n",
        "\n",
        "organism = orangecontrib.bioinformatics.kegg.Organism(\"Methylosinus trichosporium\")\n",
        "genes = organism.genes\n",
        "gene_entry = genes[\"CQW49_13850\"]\n",
        "print(gene_entry.entry, gene_entry.definition)\n",
        "\n",
        "organism = orangecontrib.bioinformatics.kegg.Organism(\"Methylosinus trichosporium\")\n",
        "genes = organism.genes\n",
        "gene_entry = genes[\"CQW49_12210\"]\n",
        "print(gene_entry.entry, gene_entry.orthology)\n",
        "\n",
        "\n",
        "organism = orangecontrib.bioinformatics.kegg.Organism(\"Methylosinus trichosporium\")\n",
        "genes = organism.genes\n",
        "gene_entry = genes[\"CQW49_04750\"]\n",
        "print(gene_entry.entry, gene_entry.definition, gene_entry.orthology)\n",
        "\n",
        "\n",
        "enzyme=orangecontrib.bioinformatics.kegg.databases.Enzyme()\n",
        "enzyme_entry = enzyme[\"ec:2.3.3.1\"]\n",
        "print(enzyme_entry.reaction)"
      ],
      "metadata": {
        "id": "ewU1EXncRfjd"
      },
      "execution_count": null,
      "outputs": []
    },
    {
      "cell_type": "code",
      "source": [
        "#script for renaming record description in Refseq or Genbank files\n",
        "\n",
        "#importing Biopythom SeqIO library\n",
        "from Bio import SeqIO\n",
        "\n",
        "#loading multiple gene elements from a fasta file\n",
        "records = list(SeqIO.parse(fastas_directory + \"OB3b/New_2017_assembly/GenBank_ASM275265v1_translated_cds.faa\", \n",
        "                           \"fasta\"))\n",
        "\n",
        "\n",
        "## 이렇게 가져와서, 기존 모델을 바꿔서 GEM 모델을 만들기도.."
      ],
      "metadata": {
        "id": "Sv06CHNiTR8l"
      },
      "execution_count": null,
      "outputs": []
    },
    {
      "cell_type": "code",
      "source": [
        "!pip install escher"
      ],
      "metadata": {
        "id": "4Gz0qXK8VaJY",
        "outputId": "84956bf4-b663-46d5-c142-68e1fa15e1f0",
        "colab": {
          "base_uri": "https://localhost:8080/"
        }
      },
      "execution_count": 7,
      "outputs": [
        {
          "output_type": "stream",
          "name": "stdout",
          "text": [
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            "Requirement already satisfied: entrypoints>=0.2.2 in /usr/local/lib/python3.7/dist-packages (from nbconvert->notebook>=4.4.1->widgetsnbextension~=3.6.0->ipywidgets<8,>=7.4.0->escher) (0.4)\n",
            "Requirement already satisfied: webencodings in /usr/local/lib/python3.7/dist-packages (from bleach->nbconvert->notebook>=4.4.1->widgetsnbextension~=3.6.0->ipywidgets<8,>=7.4.0->escher) (0.5.1)\n",
            "Requirement already satisfied: pyparsing!=3.0.5,>=2.0.2 in /usr/local/lib/python3.7/dist-packages (from packaging->pytest<5,>=4.0.1->escher) (3.0.9)\n"
          ]
        }
      ]
    },
    {
      "cell_type": "code",
      "source": [
        "!jupyter nbextension list"
      ],
      "metadata": {
        "colab": {
          "base_uri": "https://localhost:8080/"
        },
        "id": "4qHZ73uD5ZVZ",
        "outputId": "b1fca93f-4095-42d9-b823-13b770aef6c7"
      },
      "execution_count": 8,
      "outputs": [
        {
          "output_type": "stream",
          "name": "stdout",
          "text": [
            "Known nbextensions:\n",
            "  config dir: /usr/local/etc/jupyter/nbconfig\n",
            "    notebook section\n",
            "      escher/extension \u001b[32m enabled \u001b[0m\n",
            "      - Validating: \u001b[32mOK\u001b[0m\n",
            "      jupyterlab-plotly/extension \u001b[32m enabled \u001b[0m\n",
            "      - Validating: \u001b[32mOK\u001b[0m\n",
            "      jupyter-js-widgets/extension \u001b[32m enabled \u001b[0m\n",
            "      - Validating: \u001b[32mOK\u001b[0m\n"
          ]
        }
      ]
    },
    {
      "cell_type": "code",
      "source": [
        "import escher\n",
        "from escher import Builder\n",
        "from time import sleep\n",
        "#from google.colab import output\n",
        "#output.enable_custom_widget_manager()\n",
        "builder = Builder(\n",
        "    model_json = r'/content/gem_methylosinus_trichosporium/model_files/iMsOB3b.json',\n",
        "    map_json = r'/content/gem_methylosinus_trichosporium/escher_metabolic_map/Methylosinus_trichosporium_OB3b_map.json')\n",
        "builder\n",
        "\n",
        "## https://escher.readthedocs.io/en/latest/escher-python.html"
      ],
      "metadata": {
        "id": "vp2NJ6avVsbH",
        "outputId": "d6d83246-a731-4706-cbb7-b037fd22521c",
        "colab": {
          "base_uri": "https://localhost:8080/",
          "height": 17,
          "referenced_widgets": [
            "542450c1efb24f9fb3dc08cb1223cea1"
          ]
        }
      },
      "execution_count": 17,
      "outputs": [
        {
          "output_type": "display_data",
          "data": {
            "text/plain": [
              "Builder()"
            ],
            "application/vnd.jupyter.widget-view+json": {
              "version_major": 2,
              "version_minor": 0,
              "model_id": "542450c1efb24f9fb3dc08cb1223cea1"
            }
          },
          "metadata": {
            "application/vnd.jupyter.widget-view+json": {
              "colab": {
                "custom_widget_manager": {
                  "url": "https://ssl.gstatic.com/colaboratory-static/widgets/colab-cdn-widget-manager/a8874ba6619b6106/manager.min.js"
                }
              }
            }
          }
        }
      ]
    }
  ]
}