diff --git a/Superbuild/UseBoost.cmake b/Superbuild/UseBoost.cmake
index c64f3d1946..e1a337fbb3 100644
--- a/Superbuild/UseBoost.cmake
+++ b/Superbuild/UseBoost.cmake
@@ -26,7 +26,11 @@ if(WIN32)
   endif()
   set(boost_LIB_PREFIX "lib")
 else()
-  set(DEBUG_POSTFIX "-yd")
+  if(BUILD_WITH_PYTHON)
+    set(DEBUG_POSTFIX "-yd")
+  else()
+    set(DEBUG_POSTFIX "-d")
+  endif()
   set(boost_LIB_PREFIX ${CMAKE_STATIC_LIBRARY_PREFIX})
   if(${arm64Supported})
     set(PLATFORM_SUFFIX "a64")
@@ -39,7 +43,11 @@ foreach(lib ${SCI_BOOST_LIBRARY})
   add_library(${lib} STATIC IMPORTED GLOBAL)
 
   if((APPLE OR UNIX) AND CMAKE_BUILD_TYPE MATCHES "Debug")
-    set(FULL_LIB_NAME "${SCI_BOOST_LIBRARY_DIR}/${boost_LIB_PREFIX}${lib}${DEBUG_POSTFIX}${CMAKE_STATIC_LIBRARY_SUFFIX}")
+    if(${lib} MATCHES "boost_python-mt")
+      set(FULL_LIB_NAME "${SCI_BOOST_LIBRARY_DIR}/${boost_LIB_PREFIX}boost_python${USER_PYTHON_VERSION_MAJOR}${USER_PYTHON_VERSION_MINOR}-mt${DEBUG_POSTFIX}-${PLATFORM_SUFFIX}${CMAKE_STATIC_LIBRARY_SUFFIX}")
+    else()
+      set(FULL_LIB_NAME "${SCI_BOOST_LIBRARY_DIR}/${boost_LIB_PREFIX}${lib}${DEBUG_POSTFIX}-${PLATFORM_SUFFIX}${CMAKE_STATIC_LIBRARY_SUFFIX}")
+    endif()
   elseif(APPLE OR UNIX)
     if(${lib} MATCHES "boost_python-mt")
       set(FULL_LIB_NAME "${SCI_BOOST_LIBRARY_DIR}/${boost_LIB_PREFIX}boost_python${USER_PYTHON_VERSION_MAJOR}${USER_PYTHON_VERSION_MINOR}-mt-${PLATFORM_SUFFIX}${CMAKE_STATIC_LIBRARY_SUFFIX}")