PMID:28720735 A Nonredundant Phosphopantetheinyl Transferase, PptA, Is a Novel Antifungal Target That Directs Secondary Metabolite, Siderophore, and Lysine Biosynthesis in Aspergillus fumigatus and Is Critical for Pathogenicity.

[CuzickA]

curation link
https://canto.phi-base.org/curs/326646a152a66e68

[CuzickA]

Note: UniProt use teleomorph name Neosartorya fumigata (and anamorph synonym) whereas NCBI taxonomy use anamorph name Aspergillus fumigatus (most commonly used).

[ValWood]

DO UniProt consistently use the telomorph name? (I forgot).

In this case, I suspect that it will seem strange to curators to see the telomorph name. Could we maintain a 'preferred species name" in the master species file?

[CuzickA]

DO UniProt consistently use the telomorph name? (I forgot).

Me too! I just looked up Marc's email and UniProt use the teleomorph name.

The PHI-Canto config file for pathogen species already displays our preferred 'Aspergillus fumigatus' in PHI-Canto.

[CuzickA]

Another one here for you to check through when you have time @ValWood

[ValWood]

I checked this one.
I tweaked the GO annotation. It was correct but using "author intent" I made some of the GO annotations IMP instead of TAS. The experiments support these MF & BP.

Everything else looked fine

My only comment is that as we were discussing, the important points (loss of pathogenicity and unaffected pathogenicity) might get a bit lost in the detail.

[CuzickA]

Conditions added.
Session approved for now so closing this ticket.
Still needs 'compared to X' and a review of the AE infective ability in the future.

[CuzickA]

Also finished control metagenotype annotations, AE compare to and AE disease interaction.

[CuzickA]

See PHI-base/phipo#206

Changed

to

as this is a filamentous fungus

[CuzickA]

Two queries to resolve with @ValWood before I can approve this session

1. RNA level
2. pH phenotype query

[CuzickA]

This session still needs

1. new GO BP term
   'dihydroxy naphthalene (DHN)-melanin'
   @ValWood have you requested this?

2. new PHI-ECO term '+ iron' Now added

3. NTR for PHIPO
   'pathogen inhibition of host defense induced acidification in phagolysome'

4. edit PHIPO term from 'pathogen-induced pH decrease in host phagolysome' to 'host defense induced acidification in phagolysome'

5. NTR for PHIPO
   'host RNA involved in a pathogen interaction, present' Now added

[ValWood]

We are trying to decide if it is appropriate to add every siderophore to GO, there are 100s/1000s?
geneontology/go-ontology#20974

but if not broad classes will be added.

[ValWood]

term added to go, so should be available in a few days.

[CuzickA]

Updated RNA annotations, now have

[CuzickA]

Still to do
Check on new GO term next week
Make PHIPO changes in PHI-base/phipo#317

[CuzickA]

GO term updated
NTR PHIPO terms added
Approving session and closing ticket

[CuzickA]

This annotation has been flagged up in a search for pathogen phenotype WT allele with WT level expression.

In this case the annotation is for a WT allele with WT level expression but with a chemical treatment added that alters the phenotype.
I will leave it for now as I cannot think of another way to make this annotation.