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Feature Request; percent homology column for non-human species expression databases #3008

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HenrikCordes opened this issue Nov 12, 2024 · 0 comments

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@HenrikCordes
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Dear @Yuri05 @msevestre ,
I'm working on a technical validation workflow for the new gene expression DBs
https://github.com/Open-Systems-Pharmacology/Gene-Expression-Databases/releases/tag/v3.0.1

Since many users would search for the human ADME gene / protein, rather than the species-specific variant, the new DBs contain the homology mapping to their corresponding human variant:
image

Here species often show 1:N mappings (multiple variants to the human homolog), as modeler, I would use the sequence homology a kind of "propability" which variant to use to capture the AMDE compound liability for human ADME gene.
Can we add the HOMOLOGY_PERCENT name type as a new column to the expression window to enable this? Something like this:
image

What is you estimate on how much work would be needed to enable this?
Let me know if you find this helpful.

On another note, would it make sense to "cluster" the process related information into this database? e.g. expression values, tissue/location, concentration / protein amount, synthesis / turnover / half-life....

@github-project-automation github-project-automation bot moved this to Under discussion (technically feasible; open for sponsorship) in OSP Suite Software Roadmap Jan 2, 2025
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