diff --git a/pkgs/tools/security/gnupg/22.nix b/pkgs/tools/security/gnupg/22.nix
index 254a345839b37..1069eb3ee240b 100644
--- a/pkgs/tools/security/gnupg/22.nix
+++ b/pkgs/tools/security/gnupg/22.nix
@@ -1,5 +1,6 @@
-{ fetchurl, stdenv, pkgconfig, libgcrypt, libassuan, libksba
+{ fetchurl, stdenv, pkgconfig, libgcrypt, libassuan, libksba, libgpgerror
 , libiconv, npth, gettext, texinfo, pcsclite, sqlite
+, buildPackages
 
 # Each of the dependencies below are optional.
 # Gnupg can be built without them at the cost of reduced functionality.
@@ -22,6 +23,7 @@ stdenv.mkDerivation rec {
     sha256 = "1n0igfn9nwdajzkcgdx7apwm9m5rpw0fg6vwskmf1rpranlqgivn";
   };
 
+  depsBuildBuild = [ buildPackages.stdenv.cc ];
   nativeBuildInputs = [ pkgconfig ];
   buildInputs = [
     libgcrypt libassuan libksba libiconv npth gettext texinfo
@@ -36,7 +38,13 @@ stdenv.mkDerivation rec {
   ''; #" fix Emacs syntax highlighting :-(
 
   pinentryBinaryPath = pinentry.binaryPath or "bin/pinentry";
-  configureFlags = optional guiSupport "--with-pinentry-pgm=${pinentry}/${pinentryBinaryPath}";
+  configureFlags = [
+    "--with-libgpg-error-prefix=${libgpgerror.dev}"
+    "--with-libgcrypt-prefix=${libgcrypt.dev}"
+    "--with-libassuan-prefix=${libassuan.dev}"
+    "--with-ksba-prefix=${libksba.dev}"
+    "--with-npth-prefix=${npth}"
+  ] ++ optional guiSupport "--with-pinentry-pgm=${pinentry}/${pinentryBinaryPath}";
 
   postInstall = ''
     mkdir -p $out/lib/systemd/user