diff --git a/pkgs/development/libraries/qt-6/default.nix b/pkgs/development/libraries/qt-6/default.nix
index 8acc044894bca..ea65e5f3ae82c 100644
--- a/pkgs/development/libraries/qt-6/default.nix
+++ b/pkgs/development/libraries/qt-6/default.nix
@@ -42,7 +42,7 @@ let
       qtModule = callPackage ./qtModule.nix { };
 
       qtbase = callPackage ./modules/qtbase.nix {
-        withGtk3 = true;
+        withGtk3 = !stdenv.hostPlatform.isMinGW;
         inherit (srcs.qtbase) src version;
         inherit developerBuild;
         inherit (darwin.apple_sdk_11_0.frameworks)
@@ -69,47 +69,49 @@ let
         ];
       };
       env = callPackage ./qt-env.nix { };
-      full = callPackage ({ env, qtbase }: env "qt-full-${qtbase.version}"
-      # `with self` is ok to use here because having these spliced is unnecessary
-      ( with self;[
-        qt3d
-        qt5compat
-        qtcharts
-        qtconnectivity
-        qtdatavis3d
-        qtdeclarative
-        qtdoc
-        qtgraphs
-        qtgrpc
-        qthttpserver
-        qtimageformats
-        qtlanguageserver
-        qtlocation
-        qtlottie
-        qtmultimedia
-        qtmqtt
-        qtnetworkauth
-        qtpositioning
-        qtsensors
-        qtserialbus
-        qtserialport
-        qtshadertools
-        qtspeech
-        qtquick3d
-        qtquick3dphysics
-        qtquickeffectmaker
-        qtquicktimeline
-        qtremoteobjects
-        qtsvg
-        qtscxml
-        qttools
-        qttranslations
-        qtvirtualkeyboard
-        qtwebchannel
-        qtwebengine
-        qtwebsockets
-        qtwebview
-      ] ++ lib.optionals (!stdenv.hostPlatform.isDarwin) [ qtwayland libglvnd ])) { };
+      full = callPackage
+        ({ env, qtbase }: env "qt-full-${qtbase.version}"
+          # `with self` is ok to use here because having these spliced is unnecessary
+          (with self;[
+            qt3d
+            qt5compat
+            qtcharts
+            qtconnectivity
+            qtdatavis3d
+            qtdeclarative
+            qtdoc
+            qtgraphs
+            qtgrpc
+            qthttpserver
+            qtimageformats
+            qtlanguageserver
+            qtlocation
+            qtlottie
+            qtmultimedia
+            qtmqtt
+            qtnetworkauth
+            qtpositioning
+            qtsensors
+            qtserialbus
+            qtserialport
+            qtshadertools
+            qtspeech
+            qtquick3d
+            qtquick3dphysics
+            qtquickeffectmaker
+            qtquicktimeline
+            qtremoteobjects
+            qtsvg
+            qtscxml
+            qttools
+            qttranslations
+            qtvirtualkeyboard
+            qtwebchannel
+            qtwebengine
+            qtwebsockets
+            qtwebview
+          ] ++ lib.optionals (!stdenv.isDarwin) [ qtwayland libglvnd ]))
+        { };
 
       qt3d = callPackage ./modules/qt3d.nix { };
       qt5compat = callPackage ./modules/qt5compat.nix { };
@@ -162,11 +164,14 @@ let
           GameController ImageCaptureCore LocalAuthentication
           MediaAccessibility MediaPlayer MetalKit Network OpenDirectory Quartz
           ReplayKit SecurityInterface Vision;
-        qtModule = callPackage ({ qtModule }: qtModule.override {
-          stdenv = if stdenv.hostPlatform.isDarwin
-            then overrideSDK stdenv { darwinMinVersion = "10.13"; darwinSdkVersion = "11.0"; }
-            else stdenv;
-        }) { };
+        qtModule = callPackage
+          ({ qtModule }: qtModule.override {
+            stdenv =
+              if stdenv.isDarwin
+              then overrideSDK stdenv { darwinMinVersion = "10.13"; darwinSdkVersion = "11.0"; }
+              else stdenv;
+          })
+          { };
         xcbuild = buildPackages.xcbuild.override {
           productBuildVer = "20A2408";
         };
@@ -176,21 +181,25 @@ let
         inherit (darwin.apple_sdk_11_0.frameworks) WebKit;
       };
 
-      wrapQtAppsHook = callPackage ({ makeBinaryWrapper }: makeSetupHook
-        {
-          name = "wrap-qt6-apps-hook";
-          propagatedBuildInputs = [ makeBinaryWrapper ];
-        } ./hooks/wrap-qt-apps-hook.sh) { };
+      wrapQtAppsHook = callPackage
+        ({ makeBinaryWrapper }: makeSetupHook
+          {
+            name = "wrap-qt6-apps-hook";
+            propagatedBuildInputs = [ makeBinaryWrapper ];
+          } ./hooks/wrap-qt-apps-hook.sh)
+        { };
 
-      qmake = callPackage ({ qtbase }: makeSetupHook
-        {
-          name = "qmake6-hook";
-          propagatedBuildInputs = [ qtbase.dev ];
-          substitutions = {
-            inherit debug;
-            fix_qmake_libtool = ./hooks/fix-qmake-libtool.sh;
-          };
-        } ./hooks/qmake-hook.sh) { };
+      qmake = callPackage
+        ({ qtbase }: makeSetupHook
+          {
+            name = "qmake6-hook";
+            propagatedBuildInputs = [ qtbase.dev ];
+            substitutions = {
+              inherit debug;
+              fix_qmake_libtool = ./hooks/fix-qmake-libtool.sh;
+            };
+          } ./hooks/qmake-hook.sh)
+        { };
     } // lib.optionalAttrs config.allowAliases {
       # Convert to a throw on 03-01-2023 and backport the change.
       # Warnings show up in various cli tool outputs, throws do not.
@@ -203,12 +212,13 @@ let
     f = addPackages;
   };
 
-  bootstrapScope = baseScope.overrideScope(final: prev: {
+  bootstrapScope = baseScope.overrideScope (final: prev: {
     qtbase = prev.qtbase.override { qttranslations = null; };
     qtdeclarative = null;
   });
 
-  finalScope = baseScope.overrideScope(final: prev: {
+  finalScope = baseScope.overrideScope (final: prev: {
     qttranslations = bootstrapScope.qttranslations;
   });
-in finalScope
+in
+finalScope
diff --git a/pkgs/development/libraries/qt-6/modules/qtbase.nix b/pkgs/development/libraries/qt-6/modules/qtbase.nix
index 26fdeceda61fb..0a16f725c4771 100644
--- a/pkgs/development/libraries/qt-6/modules/qtbase.nix
+++ b/pkgs/development/libraries/qt-6/modules/qtbase.nix
@@ -4,6 +4,7 @@
 , patches ? [ ]
 , version
 , coreutils
+, buildPackages
 , bison
 , flex
 , gdb
@@ -79,6 +80,8 @@
 , EventKit
 , GSS
 , MetalKit
+  # mingw
+, pkgsBuildBuild
   # optional dependencies
 , cups
 , libmysqlclient
@@ -96,6 +99,7 @@
 
 let
   debugSymbols = debug || developerBuild;
+  isCrossBuild = !stdenv.buildPlatform.canExecute stdenv.hostPlatform;
 in
 stdenv.mkDerivation rec {
   pname = "qtbase";
@@ -110,7 +114,6 @@ stdenv.mkDerivation rec {
     openssl
     sqlite
     zlib
-    unixODBC
     # Text rendering
     harfbuzz
     icu
@@ -119,14 +122,16 @@ stdenv.mkDerivation rec {
     libpng
     pcre2
     pcre
-    libproxy
     zstd
-    double-conversion
     libb2
     md4c
+    double-conversion
+  ] ++ lib.optionals (!stdenv.hostPlatform.isMinGW) [
+    libproxy
     dbus
     glib
     # unixODBC drivers
+    unixODBC
     unixODBCDrivers.psql
     unixODBCDrivers.sqlite
     unixODBCDrivers.mariadb
@@ -174,11 +179,16 @@ stdenv.mkDerivation rec {
     EventKit
     GSS
     MetalKit
-  ] ++ lib.optional libGLSupported libGL;
+  ] ++ lib.optionals libGLSupported [
+    libGL
+  ] ++ lib.optionals stdenv.hostPlatform.isMinGW [
+    vulkan-headers
+    vulkan-loader
+  ];
 
-  buildInputs = [
+  buildInputs = lib.optionals (lib.meta.availableOn stdenv.hostPlatform at-spi2-core) [
     at-spi2-core
-  ] ++ lib.optionals (!stdenv.hostPlatform.isDarwin) [
+  ] ++ lib.optionals (lib.meta.availableOn stdenv.hostPlatform libinput) [
     libinput
   ] ++ lib.optionals (stdenv.hostPlatform.isDarwin && stdenv.hostPlatform.isx86_64) [
     AppKit
@@ -186,9 +196,9 @@ stdenv.mkDerivation rec {
   ]
   ++ lib.optional withGtk3 gtk3
   ++ lib.optional developerBuild gdb
-  ++ lib.optional (cups != null) cups
-  ++ lib.optional (libmysqlclient != null) libmysqlclient
-  ++ lib.optional (postgresql != null) postgresql;
+  ++ lib.optional (cups != null && lib.meta.availableOn stdenv.hostPlatform cups) cups
+  ++ lib.optional (libmysqlclient != null && !stdenv.hostPlatform.isMinGW) libmysqlclient
+  ++ lib.optional (postgresql != null && lib.meta.availableOn stdenv.hostPlatform postgresql) postgresql;
 
   nativeBuildInputs = [ bison flex gperf lndir perl pkg-config which cmake xmlstarlet ninja ]
     ++ lib.optionals stdenv.hostPlatform.isDarwin [ moveBuildTree ];
@@ -203,7 +213,7 @@ stdenv.mkDerivation rec {
 
   # https://bugreports.qt.io/browse/QTBUG-97568
   postPatch = ''
-    substituteInPlace src/corelib/CMakeLists.txt --replace-fail "/bin/ls" "${coreutils}/bin/ls"
+    substituteInPlace src/corelib/CMakeLists.txt --replace-fail "/bin/ls" "${buildPackages.coreutils}/bin/ls"
   '' + lib.optionalString stdenv.hostPlatform.isDarwin ''
     substituteInPlace cmake/QtPublicAppleHelpers.cmake --replace-fail "/usr/bin/xcrun" "${xcbuild}/bin/xcrun"
   '';
@@ -232,7 +242,11 @@ stdenv.mkDerivation rec {
   ] ++ lib.optionals stdenv.hostPlatform.isDarwin [
     # error: 'path' is unavailable: introduced in macOS 10.15
     "-DQT_FEATURE_cxx17_filesystem=OFF"
-  ] ++ lib.optional (qttranslations != null) "-DINSTALL_TRANSLATIONSDIR=${qttranslations}/translations";
+  ] ++ lib.optionals isCrossBuild [
+    "-DQT_HOST_PATH=${pkgsBuildBuild.qt6.qtbase}"
+    "-DQt6HostInfo_DIR=${pkgsBuildBuild.qt6.qtbase}/lib/cmake/Qt6HostInfo"
+  ]
+  ++ lib.optional (qttranslations != null && !isCrossBuild) "-DINSTALL_TRANSLATIONSDIR=${qttranslations}/translations";
 
   env.NIX_LDFLAGS = toString (lib.optionals stdenv.hostPlatform.isDarwin [
     # Undefined symbols for architecture arm64: "___gss_c_nt_hostbased_service_oid_desc"
@@ -253,6 +267,8 @@ stdenv.mkDerivation rec {
 
   dontStrip = debugSymbols;
 
+  dontWrapQtApps = true;
+
   setupHook = ../hooks/qtbase-setup-hook.sh;
 
   meta = with lib; {
@@ -260,6 +276,6 @@ stdenv.mkDerivation rec {
     description = "A cross-platform application framework for C++";
     license = with licenses; [ fdl13Plus gpl2Plus lgpl21Plus lgpl3Plus ];
     maintainers = with maintainers; [ milahu nickcao LunNova ];
-    platforms = platforms.unix;
+    platforms = platforms.unix ++ platforms.windows;
   };
 }