diff --git a/pkgs/by-name/cy/cynthion/package.nix b/pkgs/by-name/cy/cynthion/package.nix
new file mode 100644
index 00000000000000..9ca3cef5a4af94
--- /dev/null
+++ b/pkgs/by-name/cy/cynthion/package.nix
@@ -0,0 +1,3 @@
+{ python3Packages }:
+
+python3Packages.toPythonApplication python3Packages.cynthion
diff --git a/pkgs/development/python-modules/apollo-fpga/default.nix b/pkgs/development/python-modules/apollo-fpga/default.nix
new file mode 100644
index 00000000000000..006e7fff06987d
--- /dev/null
+++ b/pkgs/development/python-modules/apollo-fpga/default.nix
@@ -0,0 +1,54 @@
+{
+  lib,
+  fetchPypi,
+  buildPythonPackage,
+  pythonOlder,
+  setuptools,
+  pyusb,
+  pyvcd,
+  prompt-toolkit,
+  pyxdg,
+  deprecation,
+}:
+
+buildPythonPackage rec {
+  pname = "apollo-fpga";
+  version = "1.1.0";
+  pyproject = true;
+  disabled = pythonOlder "3.8";
+
+  src = fetchPypi {
+    inherit version;
+    pname = "apollo_fpga";
+    hash = "sha256-dLccmQ/2ZhQqL17JkpAhtuO5jZ3oUuIVcuYdQR0zwhQ=";
+  };
+
+  postPatch = ''
+    substituteInPlace pyproject.toml \
+      --replace-fail '"setuptools-git-versioning<2"' "" \
+      --replace-fail 'dynamic = ["version"]' 'version = "${version}"'
+  '';
+
+  build-system = [
+    setuptools
+  ];
+
+  dependencies = [
+    pyusb
+    pyvcd
+    prompt-toolkit
+    pyxdg
+    deprecation
+  ];
+
+  pythonImportsCheck = [
+    "apollo_fpga"
+  ];
+
+  meta = {
+    description = "microcontroller-based FPGA / JTAG programmer";
+    homepage = "https://github.com/greatscottgadgets/apollo";
+    license = lib.licenses.bsd3;
+    maintainers = with lib.maintainers; [ carlossless ];
+  };
+}
diff --git a/pkgs/development/python-modules/cynthion/default.nix b/pkgs/development/python-modules/cynthion/default.nix
new file mode 100644
index 00000000000000..ea6e803a57a390
--- /dev/null
+++ b/pkgs/development/python-modules/cynthion/default.nix
@@ -0,0 +1,89 @@
+{
+  lib,
+  fetchPypi,
+  fetchFromGitHub,
+  buildPythonPackage,
+  amaranth,
+  pythonOlder,
+  setuptools,
+  future,
+  libusb1,
+  prompt-toolkit,
+  pyfwup,
+  pyserial,
+  pyusb,
+  tabulate,
+  tomli,
+  tqdm,
+  pygreat,
+  apollo-fpga,
+  luna-usb,
+  luna-soc,
+  pytestCheckHook,
+}:
+
+let
+  amaranth_0_4 = amaranth.overridePythonAttrs rec {
+    version = "0.4.1";
+
+    src = fetchFromGitHub {
+      owner = "amaranth-lang";
+      repo = "amaranth";
+      rev = "v${version}";
+      sha256 = "sha256-VMgycvxkphdpWIib7aZwh588En145RgYlG2Zfi6nnDo=";
+    };
+  };
+in
+
+buildPythonPackage rec {
+  pname = "cynthion";
+  version = "0.1.7";
+  pyproject = true;
+  disabled = pythonOlder "3.8";
+
+  src = fetchPypi {
+    inherit pname version;
+    hash = "sha256-kBf3L4+2bBfdQ/6aoQcg0RG5Yt9dkS8MRCahmppBWko=";
+  };
+
+  postPatch = ''
+    substituteInPlace pyproject.toml \
+      --replace-fail '"setuptools-git-versioning<2"' "" \
+      --replace-fail 'dynamic = ["version"]' 'version = "${version}"'
+  '';
+
+  build-system = [
+    setuptools
+  ];
+
+  dependencies = [
+    future
+    libusb1
+    prompt-toolkit
+    pyfwup
+    pyserial
+    pyusb
+    tabulate
+    tomli
+    tqdm
+    pygreat
+    apollo-fpga
+    amaranth_0_4
+    luna-usb
+    luna-soc
+  ];
+
+  nativeCheckInputs = [
+    pytestCheckHook
+  ];
+
+  pythonImportsCheck = [ "cynthion" ];
+
+  meta = {
+    description = "Python package and utilities for the Great Scott Gadgets Cynthion USB Test Instrument";
+    homepage = "https://github.com/greatscottgadgets/cynthion";
+    license = lib.licenses.bsd3;
+    maintainers = with lib.maintainers; [ carlossless ];
+    platforms = lib.platforms.linux ++ lib.platforms.darwin;
+  };
+}
diff --git a/pkgs/development/python-modules/luna-soc/default.nix b/pkgs/development/python-modules/luna-soc/default.nix
new file mode 100644
index 00000000000000..c0b67d03117116
--- /dev/null
+++ b/pkgs/development/python-modules/luna-soc/default.nix
@@ -0,0 +1,44 @@
+{
+  lib,
+  fetchPypi,
+  buildPythonPackage,
+  pythonOlder,
+  setuptools,
+  luna-usb,
+}:
+
+buildPythonPackage rec {
+  pname = "luna-soc";
+  version = "0.2.0";
+  pyproject = true;
+  disabled = pythonOlder "3.8";
+
+  src = fetchPypi {
+    inherit version;
+    pname = "luna_soc";
+    hash = "sha256-Ohz/dkUuV/yoEphB7/YohuCp5GMQ//0NF1BPySg3IeU=";
+  };
+
+  postPatch = ''
+    substituteInPlace pyproject.toml \
+      --replace-fail '"setuptools-git-versioning<2"' "" \
+      --replace-fail 'dynamic = ["version"]' 'version = "${version}"'
+  '';
+
+  build-system = [
+    setuptools
+  ];
+
+  dependencies = [ luna-usb ];
+
+  pythonImportsCheck = [
+    "luna_soc"
+  ];
+
+  meta = {
+    description = "Amaranth HDL libary for building USB-capable SoC designs.";
+    homepage = "https://github.com/greatscottgadgets/luna-soc";
+    license = lib.licenses.bsd3;
+    maintainers = with lib.maintainers; [ carlossless ];
+  };
+}
diff --git a/pkgs/development/python-modules/luna-usb/default.nix b/pkgs/development/python-modules/luna-usb/default.nix
new file mode 100644
index 00000000000000..b02e63d91be6d2
--- /dev/null
+++ b/pkgs/development/python-modules/luna-usb/default.nix
@@ -0,0 +1,87 @@
+{
+  lib,
+  fetchFromGitHub,
+  buildPythonPackage,
+  pythonOlder,
+
+  # build-system
+  setuptools,
+
+   # dependencies
+  libusb1,
+  pyserial,
+  pyusb,
+  pyvcd,
+  amaranth,
+  usb-protocol,
+
+  # tests
+  pytestCheckHook,
+  apollo-fpga
+}:
+
+let
+  amaranth_0_4 = amaranth.overridePythonAttrs rec {
+    version = "0.4.1";
+
+    src = fetchFromGitHub {
+      owner = "amaranth-lang";
+      repo = "amaranth";
+      rev = "v${version}";
+      sha256 = "sha256-VMgycvxkphdpWIib7aZwh588En145RgYlG2Zfi6nnDo=";
+    };
+  };
+in
+
+buildPythonPackage rec {
+  pname = "luna-usb";
+  version = "0.1.2";
+  pyproject = true;
+  disabled = pythonOlder "3.8";
+
+  src = fetchFromGitHub {
+    owner = "greatscottgadgets";
+    repo = "luna";
+    rev = "refs/tags/${version}";
+    hash = "sha256-T9V0rI6vcEpM3kN/duRni6v2plCU4B379Zx07dBGKjk=";
+  };
+
+  postPatch = ''
+    substituteInPlace pyproject.toml \
+      --replace-fail '"setuptools-git-versioning<2"' "" \
+      --replace-fail 'dynamic = ["version"]' 'version = "${version}"'
+  '';
+
+  build-system = [
+    setuptools
+  ];
+
+  dependencies = [
+    libusb1
+    pyserial
+    pyusb
+    pyvcd
+    amaranth_0_4
+    usb-protocol
+  ];
+
+  nativeCheckInputs = [
+    pytestCheckHook
+    apollo-fpga
+  ];
+
+  pytestFlagsArray = [
+    "tests/"
+  ];
+
+  pythonImportsCheck = [
+    "luna"
+  ];
+
+  meta = {
+    description = "Amaranth HDL framework for monitoring, hacking, and developing USB devices";
+    homepage = "https://github.com/greatscottgadgets/luna";
+    license = lib.licenses.bsd3;
+    maintainers = with lib.maintainers; [ carlossless ];
+  };
+}
diff --git a/pkgs/development/python-modules/pygreat/default.nix b/pkgs/development/python-modules/pygreat/default.nix
index 6f66c9eb5dc7d2..ea656eea2b9cca 100644
--- a/pkgs/development/python-modules/pygreat/default.nix
+++ b/pkgs/development/python-modules/pygreat/default.nix
@@ -1,41 +1,52 @@
 {
   lib,
   buildPythonPackage,
-  isPy3k,
-  fetchFromGitHub,
+  fetchPypi,
+  setuptools,
+  pythonOlder,
+  pythonRelaxDepsHook,
   future,
   pyusb,
 }:
 
-buildPythonPackage {
+buildPythonPackage rec {
   pname = "pygreat";
-  version = "2019.5.1.dev0";
-  format = "setuptools";
-
-  src = fetchFromGitHub {
-    owner = "greatscottgadgets";
-    repo = "libgreat";
-    rev = "14c00b7c8f036f4d467e4b1a324ffa3566b126fa";
-    sha256 = "1h0z83k1k4z8j36z936h61l8j3cjr3wsxr86k91v5c5h93g9dkqh";
+  version = "2024.0.2";
+  pyproject = true;
+  disabled = pythonOlder "3.8";
+
+  src = fetchPypi {
+    inherit pname version;
+    hash = "sha256-VGZyvGLPyA6tOVh7boz4j/6o/iQ9mRvULOleFypGHGY=";
   };
 
-  propagatedBuildInputs = [
+  postPatch = ''
+    substituteInPlace pyproject.toml \
+      --replace-fail '"setuptools-git-versioning<2"' "" \
+      --replace-fail 'dynamic = ["version"]' 'version = "${version}"'
+  '';
+
+  build-system = [
+    setuptools
+  ];
+
+  pythonRemoveDeps = [
+    "backports.functools-lru-cache"
+  ];
+
+  dependencies = [
     future
     pyusb
   ];
 
-  disabled = !isPy3k;
-
-  preBuild = ''
-    cd host
-    substituteInPlace setup.py --replace "'backports.functools_lru_cache'" ""
-    substituteInPlace pygreat/comms.py --replace "from backports.functools_lru_cache import lru_cache as memoize_with_lru_cache" "from functools import lru_cache as memoize_with_lru_cache"
-    echo "$version" > ../VERSION
-  '';
+  pythonImportsCheck = [
+    "pygreat"
+  ];
 
-  meta = with lib; {
+  meta = {
     description = "Python library for talking with libGreat devices";
     homepage = "https://greatscottgadgets.com/greatfet/";
-    license = with licenses; [ bsd3 ];
+    license = with lib.licenses; [ bsd3 ];
+    maintainers = with lib.maintainers; [ carlossless ];
   };
 }
diff --git a/pkgs/development/python-modules/usb-protocol/default.nix b/pkgs/development/python-modules/usb-protocol/default.nix
new file mode 100644
index 00000000000000..10dda92f321899
--- /dev/null
+++ b/pkgs/development/python-modules/usb-protocol/default.nix
@@ -0,0 +1,49 @@
+{
+  lib,
+  fetchPypi,
+  buildPythonPackage,
+  pythonOlder,
+  setuptools,
+  construct,
+  pytestCheckHook,
+}:
+
+buildPythonPackage rec {
+  pname = "usb-protocol";
+  version = "0.9.1";
+  pyproject = true;
+  disabled = pythonOlder "3.8";
+
+  src = fetchPypi {
+    inherit version;
+    pname = "usb_protocol";
+    hash = "sha256-5v9M+WJ5v7XQEH3ZxuTz3gN2LQ9hNvQsSwJH4H3S/iQ=";
+  };
+
+  postPatch = ''
+    substituteInPlace pyproject.toml \
+      --replace-fail '"setuptools-git-versioning<2"' "" \
+      --replace-fail 'dynamic = ["version"]' 'version = "${version}"'
+  '';
+
+  build-system = [
+    setuptools
+  ];
+
+  dependencies = [ construct ];
+
+  nativeCheckInputs = [
+    pytestCheckHook
+  ];
+
+  pythonImportsCheck = [
+    "usb_protocol"
+  ];
+
+  meta = {
+    description = "Python library providing utilities, data structures, constants, parsers, and tools for working with the USB protocol.";
+    homepage = "https://github.com/greatscottgadgets/python-usb-protocol";
+    license = lib.licenses.bsd3;
+    maintainers = with lib.maintainers; [ carlossless ];
+  };
+}
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index 732514205908a8..544e16a9026ee8 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -696,6 +696,8 @@ self: super: with self; {
 
   aplpy = callPackage ../development/python-modules/aplpy { };
 
+  apollo-fpga = callPackage ../development/python-modules/apollo-fpga { };
+
   app-model = callPackage ../development/python-modules/app-model { };
 
   appdirs = callPackage ../development/python-modules/appdirs { };
@@ -2808,6 +2810,8 @@ self: super: with self; {
 
   cymruwhois = callPackage ../development/python-modules/cymruwhois { };
 
+  cynthion = callPackage ../development/python-modules/cynthion { };
+
   cypari2 = callPackage ../development/python-modules/cypari2 { };
 
   cypherpunkpay = callPackage ../development/python-modules/cypherpunkpay { };
@@ -7531,6 +7535,10 @@ self: super: with self; {
 
   lunarcalendar = callPackage ../development/python-modules/lunarcalendar { };
 
+  luna-soc = callPackage ../development/python-modules/luna-soc { };
+
+  luna-usb = callPackage ../development/python-modules/luna-usb { };
+
   luqum = callPackage ../development/python-modules/luqum { };
 
   luxor = callPackage ../development/python-modules/luxor { };
@@ -17170,6 +17178,8 @@ self: super: with self; {
 
   usb-monitor = callPackage ../development/python-modules/usb-monitor { };
 
+  usb-protocol = callPackage ../development/python-modules/usb-protocol { };
+
   usbrelay-py = callPackage ../os-specific/linux/usbrelay/python.nix { };
 
   usbtmc = callPackage ../development/python-modules/usbtmc { };