ChemicalEntity (PUBCHEM:644073) <related_to> BiologicalProcessOrActivity, Gene, Pathway <related_to> DiseaseOrPhenotypicFeature (MONDO:000235)

[sstemann]

Query: bupeDental.json
PK: 8c6ea099-d82e-46b4-807f-c57fde291736

Looking for ideas of how to represent oral PH

[colleenXu]

Does "oral pH" refer to acidity in the mouth (like saliva acidity)? I found these two terms related to saliva pH measurements, with x-refs to LOINC codes. However, I'm not sure how many knowledge sources would have these terms...pH:LsCnc:Pt:Saliva:Qn and pH | Saliva | Chemistry - non-challenge

---

I tried browsing this topic...It seemed like there was a lack of information + a bunch of reasoning that I'm not sure this tool could handle:

• I could only find very limited info on how acidic Buprenorphine is
• I'm using a bunch of reasoning that I'm not sure this tool can use.
  • context of taking sublingual buprenorphine: it seems to involve holding it in the mouth for several min - 15 min. And patients were supposedly told not to drink for 15-30 min after taking it (vs rinsing the mouth right after would help if it was very acidic)
  • what side effects are occurring more in patients taking sublingual Buprenorphine vs other routes of administration (ones used for long-term treatment...oral?)? The xerostomia (less saliva / dry mouth) likely occurs in both cases, but the "exposing the inside of the mouth to probably-acidic stuff for a long time" happens only with the sublingual...
  • related to the above point, how do we tell apart stuff that happens "due to xerostomia" vs what happens with "long term exposure to acidic stuff"?
  • Are the side effects of sublingual buprenorphine similar to that of other conditions that expose the inside of the mouth to "acidic stuff" for a long time? Those conditions include GERD, stuff with vomiting (bulimia, chronic alcoholism, even pregnancy), and stuff like "drinking lots of soda".

---

Another aside: There's a lot of terms related to symptoms that could be used in queries:

• Tooth Erosion
• acid erosion of teeth
• Burning mouth IDs (HPO, UMLS)
• Fragile teeth, Premature loss of permanent teeth, Tooth abscess
• dental cavities / caries
• related symptoms: bad breath, Oral cavity bleeding, Oral bleeding
• saliva stuff: Abnormality of salivation, Xerostomia