Aula_04.ipynb

{
  "nbformat": 4,
  "nbformat_minor": 0,
  "metadata": {
    "colab": {
      "name": "Imersao_Dados_Aula_04.ipynb",
      "provenance": [],
      "collapsed_sections": [
        "X_Lg2XTu20ND"
      ]
    },
    "kernelspec": {
      "name": "python3",
      "display_name": "Python 3"
    },
    "language_info": {
      "name": "python"
    }
  },
  "cells": [
    {
      "cell_type": "code",
      "metadata": {
        "id": "Vw8sW4p1sUUn"
      },
      "source": [
        "import pandas as pd\n",
        "\n",
        "url_dados = 'https://github.com/alura-cursos/imersaodados3/blob/main/dados/dados_experimentos.zip?raw=true'\n",
        "\n",
        "dados = pd.read_csv(url_dados, compression = 'zip')"
      ],
      "execution_count": null,
      "outputs": []
    },
    {
      "cell_type": "code",
      "metadata": {
        "id": "cbF_jlGksVfY"
      },
      "source": [
        "mapa = {'droga': 'composto'}\n",
        "dados.rename(columns=mapa, inplace=True)"
      ],
      "execution_count": null,
      "outputs": []
    },
    {
      "cell_type": "markdown",
      "metadata": {
        "id": "hg2Lz3uoYUPx"
      },
      "source": [
        "#Aula 4"
      ]
    },
    {
      "cell_type": "markdown",
      "metadata": {
        "id": "at6B8esQVKnu"
      },
      "source": [
        "Olá cientista!\n",
        "\n",
        "Seja bem vindo e bem vinda à aula 04!\n",
        "\n",
        "Na aula passada, exploramos a relação e a correlação entre nossas variáveis. \n",
        "Estudamos a função ```crosstab```, gráfico de dispersão, linha de tendência, correlação entre variáveis e mapa de calor. Puxa, foi muita coisa!\n",
        "\n",
        "Você conseguiur resolver os desafios que o Guilherme, o Thiago e a Vanessa deixaram pra vocês? Esperamos que sim porque hoje, vamos mergulhar na nossa penúltima aula!\n",
        "\n",
        "A primeira coisa que vamos fazer para essa aula é abrir a nossa outra base de dados. Para baixá-la vamos acessar o github para copiarmos o link do arquivo. No repositório nós temos dois arquivos: os dados_experimentos.zip e o dados_arquivos.csv. Nós vamos agora trabalhar com os dados_arquivos.csv.\n",
        "\n",
        "Vamos clicar com o botão esquerdo; assim que ele abrir, vamos clicar na opção \"View raw\" com o botão direito, e selecionar a opção \"copiar endereço do link\".\n",
        "\n",
        "Vamos importar o pandas(caso você não tenha importado ainda) para nos ajudar a ler essa base de dados, através do seguinte código:"
      ]
    },
    {
      "cell_type": "code",
      "metadata": {
        "id": "V2HZI6cbDAY3"
      },
      "source": [
        "dados_resultados = pd.read_csv('https://github.com/alura-cursos/imersaodados3/blob/main/dados/dados_resultados.csv?raw=true')"
      ],
      "execution_count": null,
      "outputs": []
    },
    {
      "cell_type": "code",
      "metadata": {
        "id": "CEHxcFL_YTuv",
        "colab": {
          "base_uri": "https://localhost:8080/",
          "height": 270
        },
        "outputId": "0e7f36a4-a1d5-4506-f1f3-4ddbfeab5ac9"
      },
      "source": [
        "dados_resultados.head()"
      ],
      "execution_count": null,
      "outputs": [
        {
          "output_type": "execute_result",
          "data": {
            "text/html": [
              "<div>\n",
              "<style scoped>\n",
              "    .dataframe tbody tr th:only-of-type {\n",
              "        vertical-align: middle;\n",
              "    }\n",
              "\n",
              "    .dataframe tbody tr th {\n",
              "        vertical-align: top;\n",
              "    }\n",
              "\n",
              "    .dataframe thead th {\n",
              "        text-align: right;\n",
              "    }\n",
              "</style>\n",
              "<table border=\"1\" class=\"dataframe\">\n",
              "  <thead>\n",
              "    <tr style=\"text-align: right;\">\n",
              "      <th></th>\n",
              "      <th>id</th>\n",
              "      <th>5-alpha_reductase_inhibitor</th>\n",
              "      <th>11-beta-hsd1_inhibitor</th>\n",
              "      <th>acat_inhibitor</th>\n",
              "      <th>acetylcholine_receptor_agonist</th>\n",
              "      <th>acetylcholine_receptor_antagonist</th>\n",
              "      <th>acetylcholinesterase_inhibitor</th>\n",
              "      <th>adenosine_receptor_agonist</th>\n",
              "      <th>adenosine_receptor_antagonist</th>\n",
              "      <th>adenylyl_cyclase_activator</th>\n",
              "      <th>adrenergic_receptor_agonist</th>\n",
              "      <th>adrenergic_receptor_antagonist</th>\n",
              "      <th>akt_inhibitor</th>\n",
              "      <th>aldehyde_dehydrogenase_inhibitor</th>\n",
              "      <th>alk_inhibitor</th>\n",
              "      <th>ampk_activator</th>\n",
              "      <th>analgesic</th>\n",
              "      <th>androgen_receptor_agonist</th>\n",
              "      <th>androgen_receptor_antagonist</th>\n",
              "      <th>anesthetic_-_local</th>\n",
              "      <th>angiogenesis_inhibitor</th>\n",
              "      <th>angiotensin_receptor_antagonist</th>\n",
              "      <th>anti-inflammatory</th>\n",
              "      <th>antiarrhythmic</th>\n",
              "      <th>antibiotic</th>\n",
              "      <th>anticonvulsant</th>\n",
              "      <th>antifungal</th>\n",
              "      <th>antihistamine</th>\n",
              "      <th>antimalarial</th>\n",
              "      <th>antioxidant</th>\n",
              "      <th>antiprotozoal</th>\n",
              "      <th>antiviral</th>\n",
              "      <th>apoptosis_stimulant</th>\n",
              "      <th>aromatase_inhibitor</th>\n",
              "      <th>atm_kinase_inhibitor</th>\n",
              "      <th>atp-sensitive_potassium_channel_antagonist</th>\n",
              "      <th>atp_synthase_inhibitor</th>\n",
              "      <th>atpase_inhibitor</th>\n",
              "      <th>atr_kinase_inhibitor</th>\n",
              "      <th>aurora_kinase_inhibitor</th>\n",
              "      <th>...</th>\n",
              "      <th>protein_synthesis_inhibitor</th>\n",
              "      <th>protein_tyrosine_kinase_inhibitor</th>\n",
              "      <th>radiopaque_medium</th>\n",
              "      <th>raf_inhibitor</th>\n",
              "      <th>ras_gtpase_inhibitor</th>\n",
              "      <th>retinoid_receptor_agonist</th>\n",
              "      <th>retinoid_receptor_antagonist</th>\n",
              "      <th>rho_associated_kinase_inhibitor</th>\n",
              "      <th>ribonucleoside_reductase_inhibitor</th>\n",
              "      <th>rna_polymerase_inhibitor</th>\n",
              "      <th>serotonin_receptor_agonist</th>\n",
              "      <th>serotonin_receptor_antagonist</th>\n",
              "      <th>serotonin_reuptake_inhibitor</th>\n",
              "      <th>sigma_receptor_agonist</th>\n",
              "      <th>sigma_receptor_antagonist</th>\n",
              "      <th>smoothened_receptor_antagonist</th>\n",
              "      <th>sodium_channel_inhibitor</th>\n",
              "      <th>sphingosine_receptor_agonist</th>\n",
              "      <th>src_inhibitor</th>\n",
              "      <th>steroid</th>\n",
              "      <th>syk_inhibitor</th>\n",
              "      <th>tachykinin_antagonist</th>\n",
              "      <th>tgf-beta_receptor_inhibitor</th>\n",
              "      <th>thrombin_inhibitor</th>\n",
              "      <th>thymidylate_synthase_inhibitor</th>\n",
              "      <th>tlr_agonist</th>\n",
              "      <th>tlr_antagonist</th>\n",
              "      <th>tnf_inhibitor</th>\n",
              "      <th>topoisomerase_inhibitor</th>\n",
              "      <th>transient_receptor_potential_channel_antagonist</th>\n",
              "      <th>tropomyosin_receptor_kinase_inhibitor</th>\n",
              "      <th>trpv_agonist</th>\n",
              "      <th>trpv_antagonist</th>\n",
              "      <th>tubulin_inhibitor</th>\n",
              "      <th>tyrosine_kinase_inhibitor</th>\n",
              "      <th>ubiquitin_specific_protease_inhibitor</th>\n",
              "      <th>vegfr_inhibitor</th>\n",
              "      <th>vitamin_b</th>\n",
              "      <th>vitamin_d_receptor_agonist</th>\n",
              "      <th>wnt_inhibitor</th>\n",
              "    </tr>\n",
              "  </thead>\n",
              "  <tbody>\n",
              "    <tr>\n",
              "      <th>0</th>\n",
              "      <td>id_000644bb2</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>...</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>1</th>\n",
              "      <td>id_000779bfc</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>...</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>2</th>\n",
              "      <td>id_000a6266a</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>...</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>3</th>\n",
              "      <td>id_0015fd391</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>...</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>4</th>\n",
              "      <td>id_001626bd3</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>...</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "    </tr>\n",
              "  </tbody>\n",
              "</table>\n",
              "<p>5 rows × 207 columns</p>\n",
              "</div>"
            ],
            "text/plain": [
              "             id  ...  wnt_inhibitor\n",
              "0  id_000644bb2  ...              0\n",
              "1  id_000779bfc  ...              0\n",
              "2  id_000a6266a  ...              0\n",
              "3  id_0015fd391  ...              0\n",
              "4  id_001626bd3  ...              0\n",
              "\n",
              "[5 rows x 207 columns]"
            ]
          },
          "metadata": {
            "tags": []
          },
          "execution_count": 4
        }
      ]
    },
    {
      "cell_type": "markdown",
      "metadata": {
        "id": "Wv7yFk6bVddQ"
      },
      "source": [
        "Repare que ele já mostra pra gente o número de colunas: 207. Ou seja, é um dataset bem extenso.\n",
        "\n",
        "Vamos começar a analisar as colunas. A primeria coluna tem o nome de \"id\", o que nos remete a um identificador. Além disso, as seguintes colunas possuem nomes bem complexos. Não são nomes muito descritivos para quem não é da área.\n",
        "\n",
        "Com a ajuda da Vanessa, descobrimos que esses nomes remetem aos mecanismos de ação das drogas. Ou seja, esses dados nos trazem a relação do mecanismo de ação do alvo (enzima, proteína, etc) com a droga utilizada. Ela também explicou sobre os termos \"agonista\" e \"antiagonista\", que ativam o receptor e o bloqueiam, respectivamente.\n",
        "\n",
        "Nesse ponto a Vanessa nos explica numa apresentação como funciona a ligação do spike com o receptor e todo o procedimento de infecção nas nossas células.\n",
        "\n",
        "Agora já sabemos que cada coluna do nosso dataframe representa um mecanismo de ação. Olhando para nosso cabeçalho percebemos que temos praticamente todos os dados com o valor 0. Será que todos os dados da tabela tem esse valor? Vamos investigar!"
      ]
    },
    {
      "cell_type": "code",
      "metadata": {
        "id": "SAXgKy4QbjDn",
        "colab": {
          "base_uri": "https://localhost:8080/"
        },
        "outputId": "2caa068d-a8a1-4642-e24e-c40e44a7c9db"
      },
      "source": [
        "dados_resultados['acetylcholine_receptor_agonist'].unique()"
      ],
      "execution_count": null,
      "outputs": [
        {
          "output_type": "execute_result",
          "data": {
            "text/plain": [
              "array([0, 1])"
            ]
          },
          "metadata": {
            "tags": []
          },
          "execution_count": 5
        }
      ]
    },
    {
      "cell_type": "markdown",
      "metadata": {
        "id": "ZjPedtNHKH7D"
      },
      "source": [
        "Olha só! Nosso resultado foi um array entre 0 e 1. Se você quiser fazer um teste com todos os outros mecanismos de ação também encontrará o resultado entre 0 e 1. Mas por que isso acontece?\n",
        "\n",
        "Cada linha é o resultado do experimento da outra base de dados dos experimentos que trabalhamos. Quando um determinado mecanismo de ação é ativado ele é indicado como 1. Quando esse mecanismo de ação não é ativado ele é detectado como 0.\n",
        "\n",
        "Portanto, todo resultado que obtivermos o número 1, saberemos que ele foi ativado.\n",
        "\n",
        "Vamos fazer uma investigação agora que pode ser muito interessante para o cientista que está trabalhando nesse projeto: qual foi o mecanismo de ação que foi mais ativado?\n",
        "\n",
        "Vamos então fazer a soma das colunas, para saber qual vai ser o que apresenta mais o número 1. Mas antes vamos verificar se todas as minhas colunas possuem somente números ou se possuem strings também nelas, através desse código:"
      ]
    },
    {
      "cell_type": "code",
      "metadata": {
        "id": "WV3a0L6zdXXf",
        "colab": {
          "base_uri": "https://localhost:8080/"
        },
        "outputId": "ee9317a1-f650-4e63-d3ca-cd3385af6d60"
      },
      "source": [
        "dados_resultados.info()"
      ],
      "execution_count": null,
      "outputs": [
        {
          "output_type": "stream",
          "text": [
            "<class 'pandas.core.frame.DataFrame'>\n",
            "RangeIndex: 23814 entries, 0 to 23813\n",
            "Columns: 207 entries, id to wnt_inhibitor\n",
            "dtypes: int64(206), object(1)\n",
            "memory usage: 37.6+ MB\n"
          ],
          "name": "stdout"
        }
      ]
    },
    {
      "cell_type": "markdown",
      "metadata": {
        "id": "VVS__zNtM4sC"
      },
      "source": [
        "Vimos que uma delas apresenta como resultado 1 objeto. Ou seja, não conseguiremos aplicar a função soma de forma direta.\n",
        "\n",
        "Vamos então fazer essa soma excluindo a coluna id, que possui dados diferentes de números em sua composição, da seguinte maneira:"
      ]
    },
    {
      "cell_type": "code",
      "metadata": {
        "id": "wBa8ABGrcc1t",
        "colab": {
          "base_uri": "https://localhost:8080/"
        },
        "outputId": "18ea29f4-4223-4b8b-c93f-3f339b6cfc7d"
      },
      "source": [
        "# contagem_moa = dados_resultados.select_dtypes('int64').sum().sort_values(ascending=False)\n",
        "contagem_moa = dados_resultados.drop('id', axis=1).sum().sort_values(ascending=False)\n",
        "contagem_moa"
      ],
      "execution_count": null,
      "outputs": [
        {
          "output_type": "execute_result",
          "data": {
            "text/plain": [
              "nfkb_inhibitor                                832\n",
              "proteasome_inhibitor                          726\n",
              "cyclooxygenase_inhibitor                      435\n",
              "dopamine_receptor_antagonist                  424\n",
              "serotonin_receptor_antagonist                 404\n",
              "                                             ... \n",
              "protein_phosphatase_inhibitor                   6\n",
              "autotaxin_inhibitor                             6\n",
              "diuretic                                        6\n",
              "erbb2_inhibitor                                 1\n",
              "atp-sensitive_potassium_channel_antagonist      1\n",
              "Length: 206, dtype: int64"
            ]
          },
          "metadata": {
            "tags": []
          },
          "execution_count": 7
        }
      ]
    },
    {
      "cell_type": "markdown",
      "metadata": {
        "id": "fF8c4vBFNYHJ"
      },
      "source": [
        "Legal. No resultado há uma informação que nos chama a atenção: os inibidores, no topo do nosso resultado, são os que possuem maior quantidade de resultados positivos. Seria um ponto a se investigar.\n",
        "\n",
        "Então aqui vamos ter o nosso primeiro desafio da aula 4. Lembrando que todos os desafios estão no final desse notebook da aula.\n",
        "\n"
      ]
    },
    {
      "cell_type": "markdown",
      "metadata": {
        "id": "iBFkVtI0VB5o"
      },
      "source": [
        "Nós fizemos uma contagem para saber onde o mecanismo de ação obteve mais respostas; agora vamos fazer outros testes.\n",
        "\n",
        "Vamos verificar se a linha específica que vamos escolher foi ativada em algum momento. E, se ela foi ativada, quantas vezes isso ocorreu?\n",
        "\n",
        "Utilizaremos o seguinte código:"
      ]
    },
    {
      "cell_type": "code",
      "metadata": {
        "id": "9B5ZPzLbezz9",
        "colab": {
          "base_uri": "https://localhost:8080/"
        },
        "outputId": "2c3cf64a-ce3b-4cc7-e48a-fc7ba8101f54"
      },
      "source": [
        "dados_resultados.drop('id', axis=1).sum(axis=1)"
      ],
      "execution_count": null,
      "outputs": [
        {
          "output_type": "execute_result",
          "data": {
            "text/plain": [
              "0        1\n",
              "1        0\n",
              "2        3\n",
              "3        0\n",
              "4        1\n",
              "        ..\n",
              "23809    1\n",
              "23810    1\n",
              "23811    0\n",
              "23812    1\n",
              "23813    0\n",
              "Length: 23814, dtype: int64"
            ]
          },
          "metadata": {
            "tags": []
          },
          "execution_count": 8
        }
      ]
    },
    {
      "cell_type": "markdown",
      "metadata": {
        "id": "HPH4fhrNXiHY"
      },
      "source": [
        "E aqui temos o nosso resultado. Na primeira linha tivemos uma única ativação. Já na segunda não obtivemos nenhuma. Na terceira tivemos 3, e assim por diante. Nesse que tivemos a resposta como 0, precisaríamos saber se foi um controle, ou se realmente a droga não ativou nenhuma resposta.\n",
        "\n",
        "Aqui embaixo temos os nossos dados dos resultados:\n"
      ]
    },
    {
      "cell_type": "code",
      "metadata": {
        "id": "w2bhDXghgnQM",
        "colab": {
          "base_uri": "https://localhost:8080/",
          "height": 270
        },
        "outputId": "16da2f81-2ff6-446e-b3f0-9fbfd2314800"
      },
      "source": [
        "dados_resultados.head()"
      ],
      "execution_count": null,
      "outputs": [
        {
          "output_type": "execute_result",
          "data": {
            "text/html": [
              "<div>\n",
              "<style scoped>\n",
              "    .dataframe tbody tr th:only-of-type {\n",
              "        vertical-align: middle;\n",
              "    }\n",
              "\n",
              "    .dataframe tbody tr th {\n",
              "        vertical-align: top;\n",
              "    }\n",
              "\n",
              "    .dataframe thead th {\n",
              "        text-align: right;\n",
              "    }\n",
              "</style>\n",
              "<table border=\"1\" class=\"dataframe\">\n",
              "  <thead>\n",
              "    <tr style=\"text-align: right;\">\n",
              "      <th></th>\n",
              "      <th>id</th>\n",
              "      <th>5-alpha_reductase_inhibitor</th>\n",
              "      <th>11-beta-hsd1_inhibitor</th>\n",
              "      <th>acat_inhibitor</th>\n",
              "      <th>acetylcholine_receptor_agonist</th>\n",
              "      <th>acetylcholine_receptor_antagonist</th>\n",
              "      <th>acetylcholinesterase_inhibitor</th>\n",
              "      <th>adenosine_receptor_agonist</th>\n",
              "      <th>adenosine_receptor_antagonist</th>\n",
              "      <th>adenylyl_cyclase_activator</th>\n",
              "      <th>adrenergic_receptor_agonist</th>\n",
              "      <th>adrenergic_receptor_antagonist</th>\n",
              "      <th>akt_inhibitor</th>\n",
              "      <th>aldehyde_dehydrogenase_inhibitor</th>\n",
              "      <th>alk_inhibitor</th>\n",
              "      <th>ampk_activator</th>\n",
              "      <th>analgesic</th>\n",
              "      <th>androgen_receptor_agonist</th>\n",
              "      <th>androgen_receptor_antagonist</th>\n",
              "      <th>anesthetic_-_local</th>\n",
              "      <th>angiogenesis_inhibitor</th>\n",
              "      <th>angiotensin_receptor_antagonist</th>\n",
              "      <th>anti-inflammatory</th>\n",
              "      <th>antiarrhythmic</th>\n",
              "      <th>antibiotic</th>\n",
              "      <th>anticonvulsant</th>\n",
              "      <th>antifungal</th>\n",
              "      <th>antihistamine</th>\n",
              "      <th>antimalarial</th>\n",
              "      <th>antioxidant</th>\n",
              "      <th>antiprotozoal</th>\n",
              "      <th>antiviral</th>\n",
              "      <th>apoptosis_stimulant</th>\n",
              "      <th>aromatase_inhibitor</th>\n",
              "      <th>atm_kinase_inhibitor</th>\n",
              "      <th>atp-sensitive_potassium_channel_antagonist</th>\n",
              "      <th>atp_synthase_inhibitor</th>\n",
              "      <th>atpase_inhibitor</th>\n",
              "      <th>atr_kinase_inhibitor</th>\n",
              "      <th>aurora_kinase_inhibitor</th>\n",
              "      <th>...</th>\n",
              "      <th>protein_synthesis_inhibitor</th>\n",
              "      <th>protein_tyrosine_kinase_inhibitor</th>\n",
              "      <th>radiopaque_medium</th>\n",
              "      <th>raf_inhibitor</th>\n",
              "      <th>ras_gtpase_inhibitor</th>\n",
              "      <th>retinoid_receptor_agonist</th>\n",
              "      <th>retinoid_receptor_antagonist</th>\n",
              "      <th>rho_associated_kinase_inhibitor</th>\n",
              "      <th>ribonucleoside_reductase_inhibitor</th>\n",
              "      <th>rna_polymerase_inhibitor</th>\n",
              "      <th>serotonin_receptor_agonist</th>\n",
              "      <th>serotonin_receptor_antagonist</th>\n",
              "      <th>serotonin_reuptake_inhibitor</th>\n",
              "      <th>sigma_receptor_agonist</th>\n",
              "      <th>sigma_receptor_antagonist</th>\n",
              "      <th>smoothened_receptor_antagonist</th>\n",
              "      <th>sodium_channel_inhibitor</th>\n",
              "      <th>sphingosine_receptor_agonist</th>\n",
              "      <th>src_inhibitor</th>\n",
              "      <th>steroid</th>\n",
              "      <th>syk_inhibitor</th>\n",
              "      <th>tachykinin_antagonist</th>\n",
              "      <th>tgf-beta_receptor_inhibitor</th>\n",
              "      <th>thrombin_inhibitor</th>\n",
              "      <th>thymidylate_synthase_inhibitor</th>\n",
              "      <th>tlr_agonist</th>\n",
              "      <th>tlr_antagonist</th>\n",
              "      <th>tnf_inhibitor</th>\n",
              "      <th>topoisomerase_inhibitor</th>\n",
              "      <th>transient_receptor_potential_channel_antagonist</th>\n",
              "      <th>tropomyosin_receptor_kinase_inhibitor</th>\n",
              "      <th>trpv_agonist</th>\n",
              "      <th>trpv_antagonist</th>\n",
              "      <th>tubulin_inhibitor</th>\n",
              "      <th>tyrosine_kinase_inhibitor</th>\n",
              "      <th>ubiquitin_specific_protease_inhibitor</th>\n",
              "      <th>vegfr_inhibitor</th>\n",
              "      <th>vitamin_b</th>\n",
              "      <th>vitamin_d_receptor_agonist</th>\n",
              "      <th>wnt_inhibitor</th>\n",
              "    </tr>\n",
              "  </thead>\n",
              "  <tbody>\n",
              "    <tr>\n",
              "      <th>0</th>\n",
              "      <td>id_000644bb2</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>...</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>1</th>\n",
              "      <td>id_000779bfc</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>...</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>2</th>\n",
              "      <td>id_000a6266a</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>...</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>3</th>\n",
              "      <td>id_0015fd391</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>...</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>4</th>\n",
              "      <td>id_001626bd3</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>...</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "    </tr>\n",
              "  </tbody>\n",
              "</table>\n",
              "<p>5 rows × 207 columns</p>\n",
              "</div>"
            ],
            "text/plain": [
              "             id  ...  wnt_inhibitor\n",
              "0  id_000644bb2  ...              0\n",
              "1  id_000779bfc  ...              0\n",
              "2  id_000a6266a  ...              0\n",
              "3  id_0015fd391  ...              0\n",
              "4  id_001626bd3  ...              0\n",
              "\n",
              "[5 rows x 207 columns]"
            ]
          },
          "metadata": {
            "tags": []
          },
          "execution_count": 9
        }
      ]
    },
    {
      "cell_type": "markdown",
      "metadata": {
        "id": "c9nJ-o1-itEW"
      },
      "source": [
        "E aqui temos a nossa base de dados:"
      ]
    },
    {
      "cell_type": "code",
      "metadata": {
        "id": "bPHy80Lqfc3T",
        "colab": {
          "base_uri": "https://localhost:8080/",
          "height": 253
        },
        "outputId": "9552feda-1803-47e2-c7ef-c629b99cf797"
      },
      "source": [
        "dados.head()"
      ],
      "execution_count": null,
      "outputs": [
        {
          "output_type": "execute_result",
          "data": {
            "text/html": [
              "<div>\n",
              "<style scoped>\n",
              "    .dataframe tbody tr th:only-of-type {\n",
              "        vertical-align: middle;\n",
              "    }\n",
              "\n",
              "    .dataframe tbody tr th {\n",
              "        vertical-align: top;\n",
              "    }\n",
              "\n",
              "    .dataframe thead th {\n",
              "        text-align: right;\n",
              "    }\n",
              "</style>\n",
              "<table border=\"1\" class=\"dataframe\">\n",
              "  <thead>\n",
              "    <tr style=\"text-align: right;\">\n",
              "      <th></th>\n",
              "      <th>id</th>\n",
              "      <th>tratamento</th>\n",
              "      <th>tempo</th>\n",
              "      <th>dose</th>\n",
              "      <th>composto</th>\n",
              "      <th>g-0</th>\n",
              "      <th>g-1</th>\n",
              "      <th>g-2</th>\n",
              "      <th>g-3</th>\n",
              "      <th>g-4</th>\n",
              "      <th>g-5</th>\n",
              "      <th>g-6</th>\n",
              "      <th>g-7</th>\n",
              "      <th>g-8</th>\n",
              "      <th>g-9</th>\n",
              "      <th>g-10</th>\n",
              "      <th>g-11</th>\n",
              "      <th>g-12</th>\n",
              "      <th>g-13</th>\n",
              "      <th>g-14</th>\n",
              "      <th>g-15</th>\n",
              "      <th>g-16</th>\n",
              "      <th>g-17</th>\n",
              "      <th>g-18</th>\n",
              "      <th>g-19</th>\n",
              "      <th>g-20</th>\n",
              "      <th>g-21</th>\n",
              "      <th>g-22</th>\n",
              "      <th>g-23</th>\n",
              "      <th>g-24</th>\n",
              "      <th>g-25</th>\n",
              "      <th>g-26</th>\n",
              "      <th>g-27</th>\n",
              "      <th>g-28</th>\n",
              "      <th>g-29</th>\n",
              "      <th>g-30</th>\n",
              "      <th>g-31</th>\n",
              "      <th>g-32</th>\n",
              "      <th>g-33</th>\n",
              "      <th>g-34</th>\n",
              "      <th>...</th>\n",
              "      <th>c-60</th>\n",
              "      <th>c-61</th>\n",
              "      <th>c-62</th>\n",
              "      <th>c-63</th>\n",
              "      <th>c-64</th>\n",
              "      <th>c-65</th>\n",
              "      <th>c-66</th>\n",
              "      <th>c-67</th>\n",
              "      <th>c-68</th>\n",
              "      <th>c-69</th>\n",
              "      <th>c-70</th>\n",
              "      <th>c-71</th>\n",
              "      <th>c-72</th>\n",
              "      <th>c-73</th>\n",
              "      <th>c-74</th>\n",
              "      <th>c-75</th>\n",
              "      <th>c-76</th>\n",
              "      <th>c-77</th>\n",
              "      <th>c-78</th>\n",
              "      <th>c-79</th>\n",
              "      <th>c-80</th>\n",
              "      <th>c-81</th>\n",
              "      <th>c-82</th>\n",
              "      <th>c-83</th>\n",
              "      <th>c-84</th>\n",
              "      <th>c-85</th>\n",
              "      <th>c-86</th>\n",
              "      <th>c-87</th>\n",
              "      <th>c-88</th>\n",
              "      <th>c-89</th>\n",
              "      <th>c-90</th>\n",
              "      <th>c-91</th>\n",
              "      <th>c-92</th>\n",
              "      <th>c-93</th>\n",
              "      <th>c-94</th>\n",
              "      <th>c-95</th>\n",
              "      <th>c-96</th>\n",
              "      <th>c-97</th>\n",
              "      <th>c-98</th>\n",
              "      <th>c-99</th>\n",
              "    </tr>\n",
              "  </thead>\n",
              "  <tbody>\n",
              "    <tr>\n",
              "      <th>0</th>\n",
              "      <td>id_000644bb2</td>\n",
              "      <td>com_droga</td>\n",
              "      <td>24</td>\n",
              "      <td>D1</td>\n",
              "      <td>b68db1d53</td>\n",
              "      <td>1.0620</td>\n",
              "      <td>0.5577</td>\n",
              "      <td>-0.2479</td>\n",
              "      <td>-0.6208</td>\n",
              "      <td>-0.1944</td>\n",
              "      <td>-1.0120</td>\n",
              "      <td>-1.0220</td>\n",
              "      <td>-0.0326</td>\n",
              "      <td>0.5548</td>\n",
              "      <td>-0.0921</td>\n",
              "      <td>1.1830</td>\n",
              "      <td>0.1530</td>\n",
              "      <td>0.5574</td>\n",
              "      <td>-0.4015</td>\n",
              "      <td>0.1789</td>\n",
              "      <td>-0.6528</td>\n",
              "      <td>-0.7969</td>\n",
              "      <td>0.6342</td>\n",
              "      <td>0.1778</td>\n",
              "      <td>-0.3694</td>\n",
              "      <td>-0.5688</td>\n",
              "      <td>-1.1360</td>\n",
              "      <td>-1.1880</td>\n",
              "      <td>0.6940</td>\n",
              "      <td>0.4393</td>\n",
              "      <td>0.2664</td>\n",
              "      <td>0.1907</td>\n",
              "      <td>0.1628</td>\n",
              "      <td>-0.2853</td>\n",
              "      <td>0.5819</td>\n",
              "      <td>0.2934</td>\n",
              "      <td>-0.5584</td>\n",
              "      <td>-0.0916</td>\n",
              "      <td>-0.3010</td>\n",
              "      <td>-0.1537</td>\n",
              "      <td>...</td>\n",
              "      <td>0.4805</td>\n",
              "      <td>0.4965</td>\n",
              "      <td>0.3680</td>\n",
              "      <td>0.8427</td>\n",
              "      <td>0.1042</td>\n",
              "      <td>0.1403</td>\n",
              "      <td>0.1758</td>\n",
              "      <td>1.2570</td>\n",
              "      <td>-0.5979</td>\n",
              "      <td>1.2250</td>\n",
              "      <td>-0.0553</td>\n",
              "      <td>0.7351</td>\n",
              "      <td>0.5810</td>\n",
              "      <td>0.9590</td>\n",
              "      <td>0.2427</td>\n",
              "      <td>0.0495</td>\n",
              "      <td>0.4141</td>\n",
              "      <td>0.8432</td>\n",
              "      <td>0.6162</td>\n",
              "      <td>-0.7318</td>\n",
              "      <td>1.2120</td>\n",
              "      <td>0.6362</td>\n",
              "      <td>-0.4427</td>\n",
              "      <td>0.1288</td>\n",
              "      <td>1.4840</td>\n",
              "      <td>0.1799</td>\n",
              "      <td>0.5367</td>\n",
              "      <td>-0.1111</td>\n",
              "      <td>-1.0120</td>\n",
              "      <td>0.6685</td>\n",
              "      <td>0.2862</td>\n",
              "      <td>0.2584</td>\n",
              "      <td>0.8076</td>\n",
              "      <td>0.5523</td>\n",
              "      <td>-0.1912</td>\n",
              "      <td>0.6584</td>\n",
              "      <td>-0.3981</td>\n",
              "      <td>0.2139</td>\n",
              "      <td>0.3801</td>\n",
              "      <td>0.4176</td>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>1</th>\n",
              "      <td>id_000779bfc</td>\n",
              "      <td>com_droga</td>\n",
              "      <td>72</td>\n",
              "      <td>D1</td>\n",
              "      <td>df89a8e5a</td>\n",
              "      <td>0.0743</td>\n",
              "      <td>0.4087</td>\n",
              "      <td>0.2991</td>\n",
              "      <td>0.0604</td>\n",
              "      <td>1.0190</td>\n",
              "      <td>0.5207</td>\n",
              "      <td>0.2341</td>\n",
              "      <td>0.3372</td>\n",
              "      <td>-0.4047</td>\n",
              "      <td>0.8507</td>\n",
              "      <td>-1.1520</td>\n",
              "      <td>-0.4201</td>\n",
              "      <td>-0.0958</td>\n",
              "      <td>0.4590</td>\n",
              "      <td>0.0803</td>\n",
              "      <td>0.2250</td>\n",
              "      <td>0.5293</td>\n",
              "      <td>0.2839</td>\n",
              "      <td>-0.3494</td>\n",
              "      <td>0.2883</td>\n",
              "      <td>0.9449</td>\n",
              "      <td>-0.1646</td>\n",
              "      <td>-0.2657</td>\n",
              "      <td>-0.3372</td>\n",
              "      <td>0.3135</td>\n",
              "      <td>-0.4316</td>\n",
              "      <td>0.4773</td>\n",
              "      <td>0.2075</td>\n",
              "      <td>-0.4216</td>\n",
              "      <td>-0.1161</td>\n",
              "      <td>-0.0499</td>\n",
              "      <td>-0.2627</td>\n",
              "      <td>0.9959</td>\n",
              "      <td>-0.2483</td>\n",
              "      <td>0.2655</td>\n",
              "      <td>...</td>\n",
              "      <td>0.4083</td>\n",
              "      <td>0.0319</td>\n",
              "      <td>0.3905</td>\n",
              "      <td>0.7099</td>\n",
              "      <td>0.2912</td>\n",
              "      <td>0.4151</td>\n",
              "      <td>-0.2840</td>\n",
              "      <td>-0.3104</td>\n",
              "      <td>-0.6373</td>\n",
              "      <td>0.2887</td>\n",
              "      <td>-0.0765</td>\n",
              "      <td>0.2539</td>\n",
              "      <td>0.4443</td>\n",
              "      <td>0.5932</td>\n",
              "      <td>0.2031</td>\n",
              "      <td>0.7639</td>\n",
              "      <td>0.5499</td>\n",
              "      <td>-0.3322</td>\n",
              "      <td>-0.0977</td>\n",
              "      <td>0.4329</td>\n",
              "      <td>-0.2782</td>\n",
              "      <td>0.7827</td>\n",
              "      <td>0.5934</td>\n",
              "      <td>0.3402</td>\n",
              "      <td>0.1499</td>\n",
              "      <td>0.4420</td>\n",
              "      <td>0.9366</td>\n",
              "      <td>0.8193</td>\n",
              "      <td>-0.4236</td>\n",
              "      <td>0.3192</td>\n",
              "      <td>-0.4265</td>\n",
              "      <td>0.7543</td>\n",
              "      <td>0.4708</td>\n",
              "      <td>0.0230</td>\n",
              "      <td>0.2957</td>\n",
              "      <td>0.4899</td>\n",
              "      <td>0.1522</td>\n",
              "      <td>0.1241</td>\n",
              "      <td>0.6077</td>\n",
              "      <td>0.7371</td>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>2</th>\n",
              "      <td>id_000a6266a</td>\n",
              "      <td>com_droga</td>\n",
              "      <td>48</td>\n",
              "      <td>D1</td>\n",
              "      <td>18bb41b2c</td>\n",
              "      <td>0.6280</td>\n",
              "      <td>0.5817</td>\n",
              "      <td>1.5540</td>\n",
              "      <td>-0.0764</td>\n",
              "      <td>-0.0323</td>\n",
              "      <td>1.2390</td>\n",
              "      <td>0.1715</td>\n",
              "      <td>0.2155</td>\n",
              "      <td>0.0065</td>\n",
              "      <td>1.2300</td>\n",
              "      <td>-0.4797</td>\n",
              "      <td>-0.5631</td>\n",
              "      <td>-0.0366</td>\n",
              "      <td>-1.8300</td>\n",
              "      <td>0.6057</td>\n",
              "      <td>-0.3278</td>\n",
              "      <td>0.6042</td>\n",
              "      <td>-0.3075</td>\n",
              "      <td>-0.1147</td>\n",
              "      <td>-0.0570</td>\n",
              "      <td>-0.0799</td>\n",
              "      <td>-0.8181</td>\n",
              "      <td>-1.5320</td>\n",
              "      <td>0.2307</td>\n",
              "      <td>0.4901</td>\n",
              "      <td>0.4780</td>\n",
              "      <td>-1.3970</td>\n",
              "      <td>4.6240</td>\n",
              "      <td>-0.0437</td>\n",
              "      <td>1.2870</td>\n",
              "      <td>-1.8530</td>\n",
              "      <td>0.6069</td>\n",
              "      <td>0.4290</td>\n",
              "      <td>0.1783</td>\n",
              "      <td>0.0018</td>\n",
              "      <td>...</td>\n",
              "      <td>-0.5477</td>\n",
              "      <td>-0.7576</td>\n",
              "      <td>-0.0444</td>\n",
              "      <td>0.1894</td>\n",
              "      <td>-0.0014</td>\n",
              "      <td>-2.3640</td>\n",
              "      <td>-0.4682</td>\n",
              "      <td>0.1210</td>\n",
              "      <td>-0.5177</td>\n",
              "      <td>-0.0604</td>\n",
              "      <td>0.1682</td>\n",
              "      <td>-0.4436</td>\n",
              "      <td>0.4963</td>\n",
              "      <td>0.1363</td>\n",
              "      <td>0.3335</td>\n",
              "      <td>0.9760</td>\n",
              "      <td>-0.0427</td>\n",
              "      <td>-0.1235</td>\n",
              "      <td>0.0959</td>\n",
              "      <td>0.0690</td>\n",
              "      <td>-0.9416</td>\n",
              "      <td>-0.7548</td>\n",
              "      <td>-0.1109</td>\n",
              "      <td>-0.6272</td>\n",
              "      <td>0.3019</td>\n",
              "      <td>0.1172</td>\n",
              "      <td>0.1093</td>\n",
              "      <td>-0.3113</td>\n",
              "      <td>0.3019</td>\n",
              "      <td>-0.0873</td>\n",
              "      <td>-0.7250</td>\n",
              "      <td>-0.6297</td>\n",
              "      <td>0.6103</td>\n",
              "      <td>0.0223</td>\n",
              "      <td>-1.3240</td>\n",
              "      <td>-0.3174</td>\n",
              "      <td>-0.6417</td>\n",
              "      <td>-0.2187</td>\n",
              "      <td>-1.4080</td>\n",
              "      <td>0.6931</td>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>3</th>\n",
              "      <td>id_0015fd391</td>\n",
              "      <td>com_droga</td>\n",
              "      <td>48</td>\n",
              "      <td>D1</td>\n",
              "      <td>8c7f86626</td>\n",
              "      <td>-0.5138</td>\n",
              "      <td>-0.2491</td>\n",
              "      <td>-0.2656</td>\n",
              "      <td>0.5288</td>\n",
              "      <td>4.0620</td>\n",
              "      <td>-0.8095</td>\n",
              "      <td>-1.9590</td>\n",
              "      <td>0.1792</td>\n",
              "      <td>-0.1321</td>\n",
              "      <td>-1.0600</td>\n",
              "      <td>-0.8269</td>\n",
              "      <td>-0.3584</td>\n",
              "      <td>-0.8511</td>\n",
              "      <td>-0.5844</td>\n",
              "      <td>-2.5690</td>\n",
              "      <td>0.8183</td>\n",
              "      <td>-0.0532</td>\n",
              "      <td>-0.8554</td>\n",
              "      <td>0.1160</td>\n",
              "      <td>-2.3520</td>\n",
              "      <td>2.1200</td>\n",
              "      <td>-1.1580</td>\n",
              "      <td>-0.7191</td>\n",
              "      <td>-0.8004</td>\n",
              "      <td>-1.4670</td>\n",
              "      <td>-0.0107</td>\n",
              "      <td>-0.8995</td>\n",
              "      <td>0.2406</td>\n",
              "      <td>-0.2479</td>\n",
              "      <td>-1.0890</td>\n",
              "      <td>-0.7575</td>\n",
              "      <td>0.0881</td>\n",
              "      <td>-2.7370</td>\n",
              "      <td>0.8745</td>\n",
              "      <td>0.5787</td>\n",
              "      <td>...</td>\n",
              "      <td>-2.1220</td>\n",
              "      <td>-0.3752</td>\n",
              "      <td>-2.3820</td>\n",
              "      <td>-3.7350</td>\n",
              "      <td>-2.9740</td>\n",
              "      <td>-1.4930</td>\n",
              "      <td>-1.6600</td>\n",
              "      <td>-3.1660</td>\n",
              "      <td>0.2816</td>\n",
              "      <td>-0.2990</td>\n",
              "      <td>-1.1870</td>\n",
              "      <td>-0.5044</td>\n",
              "      <td>-1.7750</td>\n",
              "      <td>-1.6120</td>\n",
              "      <td>-0.9215</td>\n",
              "      <td>-1.0810</td>\n",
              "      <td>-3.0520</td>\n",
              "      <td>-3.4470</td>\n",
              "      <td>-2.7740</td>\n",
              "      <td>-1.8460</td>\n",
              "      <td>-0.5568</td>\n",
              "      <td>-3.3960</td>\n",
              "      <td>-2.9510</td>\n",
              "      <td>-1.1550</td>\n",
              "      <td>-3.2620</td>\n",
              "      <td>-1.5390</td>\n",
              "      <td>-2.4600</td>\n",
              "      <td>-0.9417</td>\n",
              "      <td>-1.5550</td>\n",
              "      <td>0.2431</td>\n",
              "      <td>-2.0990</td>\n",
              "      <td>-0.6441</td>\n",
              "      <td>-5.6300</td>\n",
              "      <td>-1.3780</td>\n",
              "      <td>-0.8632</td>\n",
              "      <td>-1.2880</td>\n",
              "      <td>-1.6210</td>\n",
              "      <td>-0.8784</td>\n",
              "      <td>-0.3876</td>\n",
              "      <td>-0.8154</td>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>4</th>\n",
              "      <td>id_001626bd3</td>\n",
              "      <td>com_droga</td>\n",
              "      <td>72</td>\n",
              "      <td>D2</td>\n",
              "      <td>7cbed3131</td>\n",
              "      <td>-0.3254</td>\n",
              "      <td>-0.4009</td>\n",
              "      <td>0.9700</td>\n",
              "      <td>0.6919</td>\n",
              "      <td>1.4180</td>\n",
              "      <td>-0.8244</td>\n",
              "      <td>-0.2800</td>\n",
              "      <td>-0.1498</td>\n",
              "      <td>-0.8789</td>\n",
              "      <td>0.8630</td>\n",
              "      <td>-0.2219</td>\n",
              "      <td>-0.5121</td>\n",
              "      <td>-0.9577</td>\n",
              "      <td>1.1750</td>\n",
              "      <td>0.2042</td>\n",
              "      <td>0.1970</td>\n",
              "      <td>0.1244</td>\n",
              "      <td>-1.7090</td>\n",
              "      <td>-0.3543</td>\n",
              "      <td>-0.5160</td>\n",
              "      <td>-0.3330</td>\n",
              "      <td>-0.2685</td>\n",
              "      <td>0.7649</td>\n",
              "      <td>0.2057</td>\n",
              "      <td>1.3720</td>\n",
              "      <td>0.6835</td>\n",
              "      <td>0.8056</td>\n",
              "      <td>-0.3754</td>\n",
              "      <td>-1.2090</td>\n",
              "      <td>0.2965</td>\n",
              "      <td>-0.0712</td>\n",
              "      <td>0.6389</td>\n",
              "      <td>0.6674</td>\n",
              "      <td>-0.0783</td>\n",
              "      <td>1.1740</td>\n",
              "      <td>...</td>\n",
              "      <td>-0.2274</td>\n",
              "      <td>0.3215</td>\n",
              "      <td>0.1535</td>\n",
              "      <td>-0.4640</td>\n",
              "      <td>-0.5943</td>\n",
              "      <td>0.3973</td>\n",
              "      <td>0.1500</td>\n",
              "      <td>0.5178</td>\n",
              "      <td>0.5159</td>\n",
              "      <td>0.6091</td>\n",
              "      <td>0.1813</td>\n",
              "      <td>-0.4249</td>\n",
              "      <td>0.7832</td>\n",
              "      <td>0.6529</td>\n",
              "      <td>0.5648</td>\n",
              "      <td>0.4817</td>\n",
              "      <td>0.0587</td>\n",
              "      <td>0.5303</td>\n",
              "      <td>0.6376</td>\n",
              "      <td>-0.3966</td>\n",
              "      <td>-1.4950</td>\n",
              "      <td>-0.9625</td>\n",
              "      <td>-0.0541</td>\n",
              "      <td>0.6273</td>\n",
              "      <td>0.4563</td>\n",
              "      <td>0.0698</td>\n",
              "      <td>0.8134</td>\n",
              "      <td>0.1924</td>\n",
              "      <td>0.6054</td>\n",
              "      <td>-0.1824</td>\n",
              "      <td>0.0042</td>\n",
              "      <td>0.0048</td>\n",
              "      <td>0.6670</td>\n",
              "      <td>1.0690</td>\n",
              "      <td>0.5523</td>\n",
              "      <td>-0.3031</td>\n",
              "      <td>0.1094</td>\n",
              "      <td>0.2885</td>\n",
              "      <td>-0.3786</td>\n",
              "      <td>0.7125</td>\n",
              "    </tr>\n",
              "  </tbody>\n",
              "</table>\n",
              "<p>5 rows × 877 columns</p>\n",
              "</div>"
            ],
            "text/plain": [
              "             id tratamento  tempo dose  ...    c-96    c-97    c-98    c-99\n",
              "0  id_000644bb2  com_droga     24   D1  ... -0.3981  0.2139  0.3801  0.4176\n",
              "1  id_000779bfc  com_droga     72   D1  ...  0.1522  0.1241  0.6077  0.7371\n",
              "2  id_000a6266a  com_droga     48   D1  ... -0.6417 -0.2187 -1.4080  0.6931\n",
              "3  id_0015fd391  com_droga     48   D1  ... -1.6210 -0.8784 -0.3876 -0.8154\n",
              "4  id_001626bd3  com_droga     72   D2  ...  0.1094  0.2885 -0.3786  0.7125\n",
              "\n",
              "[5 rows x 877 columns]"
            ]
          },
          "metadata": {
            "tags": []
          },
          "execution_count": 10
        }
      ]
    },
    {
      "cell_type": "markdown",
      "metadata": {
        "id": "ailRL013iv5G"
      },
      "source": [
        "Na base de dados resultados não temos a informação que queremos, referente ao tratamento. Nós só temos a coluna tratamento na base de dados inteira.\n",
        "\n",
        "No tratamento só temos a coluna id, e os mecanismos de ação que foram ativados por aquela coluna. Então, agora, precisamos de alguma maneira, mesclar essas informações.\n",
        "\n",
        "Antes de fazer esse passo, de mesclar, vamos criar duas novas colunas na base de dados resultado. Vamos criar uma primeira coluna que vamos chamar de n_moa(número de moas ativos), que é justamente o que havíamos calculado anteriormente, dessa maneira:"
      ]
    },
    {
      "cell_type": "code",
      "metadata": {
        "id": "HS0ZHSeTjFrr"
      },
      "source": [
        "dados_resultados['n_moa'] = dados_resultados.drop('id', axis=1).sum(axis=1)"
      ],
      "execution_count": null,
      "outputs": []
    },
    {
      "cell_type": "markdown",
      "metadata": {
        "id": "g4fz70-SkKrK"
      },
      "source": [
        " Vamos então verificar se a coluna apresenta resultados diferentes de 0; se for diferente de 0 ela retorna a mensagem 'true'; se for igual a 0 retorna 'false':"
      ]
    },
    {
      "cell_type": "code",
      "metadata": {
        "id": "MNMsak-ih9PQ",
        "colab": {
          "base_uri": "https://localhost:8080/"
        },
        "outputId": "b83492ff-b1b0-4e4b-dd22-fd6fc90b3866"
      },
      "source": [
        "dados_resultados['n_moa'] != 0"
      ],
      "execution_count": null,
      "outputs": [
        {
          "output_type": "execute_result",
          "data": {
            "text/plain": [
              "0         True\n",
              "1        False\n",
              "2         True\n",
              "3        False\n",
              "4         True\n",
              "         ...  \n",
              "23809     True\n",
              "23810     True\n",
              "23811    False\n",
              "23812     True\n",
              "23813    False\n",
              "Name: n_moa, Length: 23814, dtype: bool"
            ]
          },
          "metadata": {
            "tags": []
          },
          "execution_count": 12
        }
      ]
    },
    {
      "cell_type": "markdown",
      "metadata": {
        "id": "rZCppZQ-la6x"
      },
      "source": [
        "Ok, então o código para criarmos e visualizarmos as duas colunas é esse:"
      ]
    },
    {
      "cell_type": "code",
      "metadata": {
        "id": "bba-i1D8hcu8",
        "colab": {
          "base_uri": "https://localhost:8080/",
          "height": 270
        },
        "outputId": "9b69dc13-1a38-4a50-c769-5228e7c1e8f3"
      },
      "source": [
        "dados_resultados['ativo_moa'] = (dados_resultados['n_moa'] != 0)\n",
        "dados_resultados.head()"
      ],
      "execution_count": null,
      "outputs": [
        {
          "output_type": "execute_result",
          "data": {
            "text/html": [
              "<div>\n",
              "<style scoped>\n",
              "    .dataframe tbody tr th:only-of-type {\n",
              "        vertical-align: middle;\n",
              "    }\n",
              "\n",
              "    .dataframe tbody tr th {\n",
              "        vertical-align: top;\n",
              "    }\n",
              "\n",
              "    .dataframe thead th {\n",
              "        text-align: right;\n",
              "    }\n",
              "</style>\n",
              "<table border=\"1\" class=\"dataframe\">\n",
              "  <thead>\n",
              "    <tr style=\"text-align: right;\">\n",
              "      <th></th>\n",
              "      <th>id</th>\n",
              "      <th>5-alpha_reductase_inhibitor</th>\n",
              "      <th>11-beta-hsd1_inhibitor</th>\n",
              "      <th>acat_inhibitor</th>\n",
              "      <th>acetylcholine_receptor_agonist</th>\n",
              "      <th>acetylcholine_receptor_antagonist</th>\n",
              "      <th>acetylcholinesterase_inhibitor</th>\n",
              "      <th>adenosine_receptor_agonist</th>\n",
              "      <th>adenosine_receptor_antagonist</th>\n",
              "      <th>adenylyl_cyclase_activator</th>\n",
              "      <th>adrenergic_receptor_agonist</th>\n",
              "      <th>adrenergic_receptor_antagonist</th>\n",
              "      <th>akt_inhibitor</th>\n",
              "      <th>aldehyde_dehydrogenase_inhibitor</th>\n",
              "      <th>alk_inhibitor</th>\n",
              "      <th>ampk_activator</th>\n",
              "      <th>analgesic</th>\n",
              "      <th>androgen_receptor_agonist</th>\n",
              "      <th>androgen_receptor_antagonist</th>\n",
              "      <th>anesthetic_-_local</th>\n",
              "      <th>angiogenesis_inhibitor</th>\n",
              "      <th>angiotensin_receptor_antagonist</th>\n",
              "      <th>anti-inflammatory</th>\n",
              "      <th>antiarrhythmic</th>\n",
              "      <th>antibiotic</th>\n",
              "      <th>anticonvulsant</th>\n",
              "      <th>antifungal</th>\n",
              "      <th>antihistamine</th>\n",
              "      <th>antimalarial</th>\n",
              "      <th>antioxidant</th>\n",
              "      <th>antiprotozoal</th>\n",
              "      <th>antiviral</th>\n",
              "      <th>apoptosis_stimulant</th>\n",
              "      <th>aromatase_inhibitor</th>\n",
              "      <th>atm_kinase_inhibitor</th>\n",
              "      <th>atp-sensitive_potassium_channel_antagonist</th>\n",
              "      <th>atp_synthase_inhibitor</th>\n",
              "      <th>atpase_inhibitor</th>\n",
              "      <th>atr_kinase_inhibitor</th>\n",
              "      <th>aurora_kinase_inhibitor</th>\n",
              "      <th>...</th>\n",
              "      <th>radiopaque_medium</th>\n",
              "      <th>raf_inhibitor</th>\n",
              "      <th>ras_gtpase_inhibitor</th>\n",
              "      <th>retinoid_receptor_agonist</th>\n",
              "      <th>retinoid_receptor_antagonist</th>\n",
              "      <th>rho_associated_kinase_inhibitor</th>\n",
              "      <th>ribonucleoside_reductase_inhibitor</th>\n",
              "      <th>rna_polymerase_inhibitor</th>\n",
              "      <th>serotonin_receptor_agonist</th>\n",
              "      <th>serotonin_receptor_antagonist</th>\n",
              "      <th>serotonin_reuptake_inhibitor</th>\n",
              "      <th>sigma_receptor_agonist</th>\n",
              "      <th>sigma_receptor_antagonist</th>\n",
              "      <th>smoothened_receptor_antagonist</th>\n",
              "      <th>sodium_channel_inhibitor</th>\n",
              "      <th>sphingosine_receptor_agonist</th>\n",
              "      <th>src_inhibitor</th>\n",
              "      <th>steroid</th>\n",
              "      <th>syk_inhibitor</th>\n",
              "      <th>tachykinin_antagonist</th>\n",
              "      <th>tgf-beta_receptor_inhibitor</th>\n",
              "      <th>thrombin_inhibitor</th>\n",
              "      <th>thymidylate_synthase_inhibitor</th>\n",
              "      <th>tlr_agonist</th>\n",
              "      <th>tlr_antagonist</th>\n",
              "      <th>tnf_inhibitor</th>\n",
              "      <th>topoisomerase_inhibitor</th>\n",
              "      <th>transient_receptor_potential_channel_antagonist</th>\n",
              "      <th>tropomyosin_receptor_kinase_inhibitor</th>\n",
              "      <th>trpv_agonist</th>\n",
              "      <th>trpv_antagonist</th>\n",
              "      <th>tubulin_inhibitor</th>\n",
              "      <th>tyrosine_kinase_inhibitor</th>\n",
              "      <th>ubiquitin_specific_protease_inhibitor</th>\n",
              "      <th>vegfr_inhibitor</th>\n",
              "      <th>vitamin_b</th>\n",
              "      <th>vitamin_d_receptor_agonist</th>\n",
              "      <th>wnt_inhibitor</th>\n",
              "      <th>n_moa</th>\n",
              "      <th>ativo_moa</th>\n",
              "    </tr>\n",
              "  </thead>\n",
              "  <tbody>\n",
              "    <tr>\n",
              "      <th>0</th>\n",
              "      <td>id_000644bb2</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>...</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>1</td>\n",
              "      <td>True</td>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>1</th>\n",
              "      <td>id_000779bfc</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>...</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>False</td>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>2</th>\n",
              "      <td>id_000a6266a</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>...</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>3</td>\n",
              "      <td>True</td>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>3</th>\n",
              "      <td>id_0015fd391</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>...</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>False</td>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>4</th>\n",
              "      <td>id_001626bd3</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>...</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>0</td>\n",
              "      <td>1</td>\n",
              "      <td>True</td>\n",
              "    </tr>\n",
              "  </tbody>\n",
              "</table>\n",
              "<p>5 rows × 209 columns</p>\n",
              "</div>"
            ],
            "text/plain": [
              "             id  5-alpha_reductase_inhibitor  ...  n_moa  ativo_moa\n",
              "0  id_000644bb2                            0  ...      1       True\n",
              "1  id_000779bfc                            0  ...      0      False\n",
              "2  id_000a6266a                            0  ...      3       True\n",
              "3  id_0015fd391                            0  ...      0      False\n",
              "4  id_001626bd3                            0  ...      1       True\n",
              "\n",
              "[5 rows x 209 columns]"
            ]
          },
          "metadata": {
            "tags": []
          },
          "execution_count": 13
        }
      ]
    },
    {
      "cell_type": "markdown",
      "metadata": {
        "id": "oOA4vQ6glg5l"
      },
      "source": [
        "Para visualizarmos basta ir até as duas últimas colunas que elas estarão lá."
      ]
    },
    {
      "cell_type": "markdown",
      "metadata": {
        "id": "4w-2eB_gm0o5"
      },
      "source": [
        "Agora que temos as duas colunas que queremos, vamos mesclar, ou então \"mergear\", as informações que queremos.\n",
        "\n",
        "Para isso vamos utilizar o merge do pandas, através desse código:"
      ]
    },
    {
      "cell_type": "code",
      "metadata": {
        "id": "0r4V83bujiao",
        "colab": {
          "base_uri": "https://localhost:8080/",
          "height": 253
        },
        "outputId": "4939b69f-1bc3-460d-de3b-32fc6b82bd70"
      },
      "source": [
        " dados_combinados = pd.merge(dados, dados_resultados[['id','n_moa', 'ativo_moa']], on='id')\n",
        " dados_combinados.head()"
      ],
      "execution_count": null,
      "outputs": [
        {
          "output_type": "execute_result",
          "data": {
            "text/html": [
              "<div>\n",
              "<style scoped>\n",
              "    .dataframe tbody tr th:only-of-type {\n",
              "        vertical-align: middle;\n",
              "    }\n",
              "\n",
              "    .dataframe tbody tr th {\n",
              "        vertical-align: top;\n",
              "    }\n",
              "\n",
              "    .dataframe thead th {\n",
              "        text-align: right;\n",
              "    }\n",
              "</style>\n",
              "<table border=\"1\" class=\"dataframe\">\n",
              "  <thead>\n",
              "    <tr style=\"text-align: right;\">\n",
              "      <th></th>\n",
              "      <th>id</th>\n",
              "      <th>tratamento</th>\n",
              "      <th>tempo</th>\n",
              "      <th>dose</th>\n",
              "      <th>composto</th>\n",
              "      <th>g-0</th>\n",
              "      <th>g-1</th>\n",
              "      <th>g-2</th>\n",
              "      <th>g-3</th>\n",
              "      <th>g-4</th>\n",
              "      <th>g-5</th>\n",
              "      <th>g-6</th>\n",
              "      <th>g-7</th>\n",
              "      <th>g-8</th>\n",
              "      <th>g-9</th>\n",
              "      <th>g-10</th>\n",
              "      <th>g-11</th>\n",
              "      <th>g-12</th>\n",
              "      <th>g-13</th>\n",
              "      <th>g-14</th>\n",
              "      <th>g-15</th>\n",
              "      <th>g-16</th>\n",
              "      <th>g-17</th>\n",
              "      <th>g-18</th>\n",
              "      <th>g-19</th>\n",
              "      <th>g-20</th>\n",
              "      <th>g-21</th>\n",
              "      <th>g-22</th>\n",
              "      <th>g-23</th>\n",
              "      <th>g-24</th>\n",
              "      <th>g-25</th>\n",
              "      <th>g-26</th>\n",
              "      <th>g-27</th>\n",
              "      <th>g-28</th>\n",
              "      <th>g-29</th>\n",
              "      <th>g-30</th>\n",
              "      <th>g-31</th>\n",
              "      <th>g-32</th>\n",
              "      <th>g-33</th>\n",
              "      <th>g-34</th>\n",
              "      <th>...</th>\n",
              "      <th>c-62</th>\n",
              "      <th>c-63</th>\n",
              "      <th>c-64</th>\n",
              "      <th>c-65</th>\n",
              "      <th>c-66</th>\n",
              "      <th>c-67</th>\n",
              "      <th>c-68</th>\n",
              "      <th>c-69</th>\n",
              "      <th>c-70</th>\n",
              "      <th>c-71</th>\n",
              "      <th>c-72</th>\n",
              "      <th>c-73</th>\n",
              "      <th>c-74</th>\n",
              "      <th>c-75</th>\n",
              "      <th>c-76</th>\n",
              "      <th>c-77</th>\n",
              "      <th>c-78</th>\n",
              "      <th>c-79</th>\n",
              "      <th>c-80</th>\n",
              "      <th>c-81</th>\n",
              "      <th>c-82</th>\n",
              "      <th>c-83</th>\n",
              "      <th>c-84</th>\n",
              "      <th>c-85</th>\n",
              "      <th>c-86</th>\n",
              "      <th>c-87</th>\n",
              "      <th>c-88</th>\n",
              "      <th>c-89</th>\n",
              "      <th>c-90</th>\n",
              "      <th>c-91</th>\n",
              "      <th>c-92</th>\n",
              "      <th>c-93</th>\n",
              "      <th>c-94</th>\n",
              "      <th>c-95</th>\n",
              "      <th>c-96</th>\n",
              "      <th>c-97</th>\n",
              "      <th>c-98</th>\n",
              "      <th>c-99</th>\n",
              "      <th>n_moa</th>\n",
              "      <th>ativo_moa</th>\n",
              "    </tr>\n",
              "  </thead>\n",
              "  <tbody>\n",
              "    <tr>\n",
              "      <th>0</th>\n",
              "      <td>id_000644bb2</td>\n",
              "      <td>com_droga</td>\n",
              "      <td>24</td>\n",
              "      <td>D1</td>\n",
              "      <td>b68db1d53</td>\n",
              "      <td>1.0620</td>\n",
              "      <td>0.5577</td>\n",
              "      <td>-0.2479</td>\n",
              "      <td>-0.6208</td>\n",
              "      <td>-0.1944</td>\n",
              "      <td>-1.0120</td>\n",
              "      <td>-1.0220</td>\n",
              "      <td>-0.0326</td>\n",
              "      <td>0.5548</td>\n",
              "      <td>-0.0921</td>\n",
              "      <td>1.1830</td>\n",
              "      <td>0.1530</td>\n",
              "      <td>0.5574</td>\n",
              "      <td>-0.4015</td>\n",
              "      <td>0.1789</td>\n",
              "      <td>-0.6528</td>\n",
              "      <td>-0.7969</td>\n",
              "      <td>0.6342</td>\n",
              "      <td>0.1778</td>\n",
              "      <td>-0.3694</td>\n",
              "      <td>-0.5688</td>\n",
              "      <td>-1.1360</td>\n",
              "      <td>-1.1880</td>\n",
              "      <td>0.6940</td>\n",
              "      <td>0.4393</td>\n",
              "      <td>0.2664</td>\n",
              "      <td>0.1907</td>\n",
              "      <td>0.1628</td>\n",
              "      <td>-0.2853</td>\n",
              "      <td>0.5819</td>\n",
              "      <td>0.2934</td>\n",
              "      <td>-0.5584</td>\n",
              "      <td>-0.0916</td>\n",
              "      <td>-0.3010</td>\n",
              "      <td>-0.1537</td>\n",
              "      <td>...</td>\n",
              "      <td>0.3680</td>\n",
              "      <td>0.8427</td>\n",
              "      <td>0.1042</td>\n",
              "      <td>0.1403</td>\n",
              "      <td>0.1758</td>\n",
              "      <td>1.2570</td>\n",
              "      <td>-0.5979</td>\n",
              "      <td>1.2250</td>\n",
              "      <td>-0.0553</td>\n",
              "      <td>0.7351</td>\n",
              "      <td>0.5810</td>\n",
              "      <td>0.9590</td>\n",
              "      <td>0.2427</td>\n",
              "      <td>0.0495</td>\n",
              "      <td>0.4141</td>\n",
              "      <td>0.8432</td>\n",
              "      <td>0.6162</td>\n",
              "      <td>-0.7318</td>\n",
              "      <td>1.2120</td>\n",
              "      <td>0.6362</td>\n",
              "      <td>-0.4427</td>\n",
              "      <td>0.1288</td>\n",
              "      <td>1.4840</td>\n",
              "      <td>0.1799</td>\n",
              "      <td>0.5367</td>\n",
              "      <td>-0.1111</td>\n",
              "      <td>-1.0120</td>\n",
              "      <td>0.6685</td>\n",
              "      <td>0.2862</td>\n",
              "      <td>0.2584</td>\n",
              "      <td>0.8076</td>\n",
              "      <td>0.5523</td>\n",
              "      <td>-0.1912</td>\n",
              "      <td>0.6584</td>\n",
              "      <td>-0.3981</td>\n",
              "      <td>0.2139</td>\n",
              "      <td>0.3801</td>\n",
              "      <td>0.4176</td>\n",
              "      <td>1</td>\n",
              "      <td>True</td>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>1</th>\n",
              "      <td>id_000779bfc</td>\n",
              "      <td>com_droga</td>\n",
              "      <td>72</td>\n",
              "      <td>D1</td>\n",
              "      <td>df89a8e5a</td>\n",
              "      <td>0.0743</td>\n",
              "      <td>0.4087</td>\n",
              "      <td>0.2991</td>\n",
              "      <td>0.0604</td>\n",
              "      <td>1.0190</td>\n",
              "      <td>0.5207</td>\n",
              "      <td>0.2341</td>\n",
              "      <td>0.3372</td>\n",
              "      <td>-0.4047</td>\n",
              "      <td>0.8507</td>\n",
              "      <td>-1.1520</td>\n",
              "      <td>-0.4201</td>\n",
              "      <td>-0.0958</td>\n",
              "      <td>0.4590</td>\n",
              "      <td>0.0803</td>\n",
              "      <td>0.2250</td>\n",
              "      <td>0.5293</td>\n",
              "      <td>0.2839</td>\n",
              "      <td>-0.3494</td>\n",
              "      <td>0.2883</td>\n",
              "      <td>0.9449</td>\n",
              "      <td>-0.1646</td>\n",
              "      <td>-0.2657</td>\n",
              "      <td>-0.3372</td>\n",
              "      <td>0.3135</td>\n",
              "      <td>-0.4316</td>\n",
              "      <td>0.4773</td>\n",
              "      <td>0.2075</td>\n",
              "      <td>-0.4216</td>\n",
              "      <td>-0.1161</td>\n",
              "      <td>-0.0499</td>\n",
              "      <td>-0.2627</td>\n",
              "      <td>0.9959</td>\n",
              "      <td>-0.2483</td>\n",
              "      <td>0.2655</td>\n",
              "      <td>...</td>\n",
              "      <td>0.3905</td>\n",
              "      <td>0.7099</td>\n",
              "      <td>0.2912</td>\n",
              "      <td>0.4151</td>\n",
              "      <td>-0.2840</td>\n",
              "      <td>-0.3104</td>\n",
              "      <td>-0.6373</td>\n",
              "      <td>0.2887</td>\n",
              "      <td>-0.0765</td>\n",
              "      <td>0.2539</td>\n",
              "      <td>0.4443</td>\n",
              "      <td>0.5932</td>\n",
              "      <td>0.2031</td>\n",
              "      <td>0.7639</td>\n",
              "      <td>0.5499</td>\n",
              "      <td>-0.3322</td>\n",
              "      <td>-0.0977</td>\n",
              "      <td>0.4329</td>\n",
              "      <td>-0.2782</td>\n",
              "      <td>0.7827</td>\n",
              "      <td>0.5934</td>\n",
              "      <td>0.3402</td>\n",
              "      <td>0.1499</td>\n",
              "      <td>0.4420</td>\n",
              "      <td>0.9366</td>\n",
              "      <td>0.8193</td>\n",
              "      <td>-0.4236</td>\n",
              "      <td>0.3192</td>\n",
              "      <td>-0.4265</td>\n",
              "      <td>0.7543</td>\n",
              "      <td>0.4708</td>\n",
              "      <td>0.0230</td>\n",
              "      <td>0.2957</td>\n",
              "      <td>0.4899</td>\n",
              "      <td>0.1522</td>\n",
              "      <td>0.1241</td>\n",
              "      <td>0.6077</td>\n",
              "      <td>0.7371</td>\n",
              "      <td>0</td>\n",
              "      <td>False</td>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>2</th>\n",
              "      <td>id_000a6266a</td>\n",
              "      <td>com_droga</td>\n",
              "      <td>48</td>\n",
              "      <td>D1</td>\n",
              "      <td>18bb41b2c</td>\n",
              "      <td>0.6280</td>\n",
              "      <td>0.5817</td>\n",
              "      <td>1.5540</td>\n",
              "      <td>-0.0764</td>\n",
              "      <td>-0.0323</td>\n",
              "      <td>1.2390</td>\n",
              "      <td>0.1715</td>\n",
              "      <td>0.2155</td>\n",
              "      <td>0.0065</td>\n",
              "      <td>1.2300</td>\n",
              "      <td>-0.4797</td>\n",
              "      <td>-0.5631</td>\n",
              "      <td>-0.0366</td>\n",
              "      <td>-1.8300</td>\n",
              "      <td>0.6057</td>\n",
              "      <td>-0.3278</td>\n",
              "      <td>0.6042</td>\n",
              "      <td>-0.3075</td>\n",
              "      <td>-0.1147</td>\n",
              "      <td>-0.0570</td>\n",
              "      <td>-0.0799</td>\n",
              "      <td>-0.8181</td>\n",
              "      <td>-1.5320</td>\n",
              "      <td>0.2307</td>\n",
              "      <td>0.4901</td>\n",
              "      <td>0.4780</td>\n",
              "      <td>-1.3970</td>\n",
              "      <td>4.6240</td>\n",
              "      <td>-0.0437</td>\n",
              "      <td>1.2870</td>\n",
              "      <td>-1.8530</td>\n",
              "      <td>0.6069</td>\n",
              "      <td>0.4290</td>\n",
              "      <td>0.1783</td>\n",
              "      <td>0.0018</td>\n",
              "      <td>...</td>\n",
              "      <td>-0.0444</td>\n",
              "      <td>0.1894</td>\n",
              "      <td>-0.0014</td>\n",
              "      <td>-2.3640</td>\n",
              "      <td>-0.4682</td>\n",
              "      <td>0.1210</td>\n",
              "      <td>-0.5177</td>\n",
              "      <td>-0.0604</td>\n",
              "      <td>0.1682</td>\n",
              "      <td>-0.4436</td>\n",
              "      <td>0.4963</td>\n",
              "      <td>0.1363</td>\n",
              "      <td>0.3335</td>\n",
              "      <td>0.9760</td>\n",
              "      <td>-0.0427</td>\n",
              "      <td>-0.1235</td>\n",
              "      <td>0.0959</td>\n",
              "      <td>0.0690</td>\n",
              "      <td>-0.9416</td>\n",
              "      <td>-0.7548</td>\n",
              "      <td>-0.1109</td>\n",
              "      <td>-0.6272</td>\n",
              "      <td>0.3019</td>\n",
              "      <td>0.1172</td>\n",
              "      <td>0.1093</td>\n",
              "      <td>-0.3113</td>\n",
              "      <td>0.3019</td>\n",
              "      <td>-0.0873</td>\n",
              "      <td>-0.7250</td>\n",
              "      <td>-0.6297</td>\n",
              "      <td>0.6103</td>\n",
              "      <td>0.0223</td>\n",
              "      <td>-1.3240</td>\n",
              "      <td>-0.3174</td>\n",
              "      <td>-0.6417</td>\n",
              "      <td>-0.2187</td>\n",
              "      <td>-1.4080</td>\n",
              "      <td>0.6931</td>\n",
              "      <td>3</td>\n",
              "      <td>True</td>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>3</th>\n",
              "      <td>id_0015fd391</td>\n",
              "      <td>com_droga</td>\n",
              "      <td>48</td>\n",
              "      <td>D1</td>\n",
              "      <td>8c7f86626</td>\n",
              "      <td>-0.5138</td>\n",
              "      <td>-0.2491</td>\n",
              "      <td>-0.2656</td>\n",
              "      <td>0.5288</td>\n",
              "      <td>4.0620</td>\n",
              "      <td>-0.8095</td>\n",
              "      <td>-1.9590</td>\n",
              "      <td>0.1792</td>\n",
              "      <td>-0.1321</td>\n",
              "      <td>-1.0600</td>\n",
              "      <td>-0.8269</td>\n",
              "      <td>-0.3584</td>\n",
              "      <td>-0.8511</td>\n",
              "      <td>-0.5844</td>\n",
              "      <td>-2.5690</td>\n",
              "      <td>0.8183</td>\n",
              "      <td>-0.0532</td>\n",
              "      <td>-0.8554</td>\n",
              "      <td>0.1160</td>\n",
              "      <td>-2.3520</td>\n",
              "      <td>2.1200</td>\n",
              "      <td>-1.1580</td>\n",
              "      <td>-0.7191</td>\n",
              "      <td>-0.8004</td>\n",
              "      <td>-1.4670</td>\n",
              "      <td>-0.0107</td>\n",
              "      <td>-0.8995</td>\n",
              "      <td>0.2406</td>\n",
              "      <td>-0.2479</td>\n",
              "      <td>-1.0890</td>\n",
              "      <td>-0.7575</td>\n",
              "      <td>0.0881</td>\n",
              "      <td>-2.7370</td>\n",
              "      <td>0.8745</td>\n",
              "      <td>0.5787</td>\n",
              "      <td>...</td>\n",
              "      <td>-2.3820</td>\n",
              "      <td>-3.7350</td>\n",
              "      <td>-2.9740</td>\n",
              "      <td>-1.4930</td>\n",
              "      <td>-1.6600</td>\n",
              "      <td>-3.1660</td>\n",
              "      <td>0.2816</td>\n",
              "      <td>-0.2990</td>\n",
              "      <td>-1.1870</td>\n",
              "      <td>-0.5044</td>\n",
              "      <td>-1.7750</td>\n",
              "      <td>-1.6120</td>\n",
              "      <td>-0.9215</td>\n",
              "      <td>-1.0810</td>\n",
              "      <td>-3.0520</td>\n",
              "      <td>-3.4470</td>\n",
              "      <td>-2.7740</td>\n",
              "      <td>-1.8460</td>\n",
              "      <td>-0.5568</td>\n",
              "      <td>-3.3960</td>\n",
              "      <td>-2.9510</td>\n",
              "      <td>-1.1550</td>\n",
              "      <td>-3.2620</td>\n",
              "      <td>-1.5390</td>\n",
              "      <td>-2.4600</td>\n",
              "      <td>-0.9417</td>\n",
              "      <td>-1.5550</td>\n",
              "      <td>0.2431</td>\n",
              "      <td>-2.0990</td>\n",
              "      <td>-0.6441</td>\n",
              "      <td>-5.6300</td>\n",
              "      <td>-1.3780</td>\n",
              "      <td>-0.8632</td>\n",
              "      <td>-1.2880</td>\n",
              "      <td>-1.6210</td>\n",
              "      <td>-0.8784</td>\n",
              "      <td>-0.3876</td>\n",
              "      <td>-0.8154</td>\n",
              "      <td>0</td>\n",
              "      <td>False</td>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>4</th>\n",
              "      <td>id_001626bd3</td>\n",
              "      <td>com_droga</td>\n",
              "      <td>72</td>\n",
              "      <td>D2</td>\n",
              "      <td>7cbed3131</td>\n",
              "      <td>-0.3254</td>\n",
              "      <td>-0.4009</td>\n",
              "      <td>0.9700</td>\n",
              "      <td>0.6919</td>\n",
              "      <td>1.4180</td>\n",
              "      <td>-0.8244</td>\n",
              "      <td>-0.2800</td>\n",
              "      <td>-0.1498</td>\n",
              "      <td>-0.8789</td>\n",
              "      <td>0.8630</td>\n",
              "      <td>-0.2219</td>\n",
              "      <td>-0.5121</td>\n",
              "      <td>-0.9577</td>\n",
              "      <td>1.1750</td>\n",
              "      <td>0.2042</td>\n",
              "      <td>0.1970</td>\n",
              "      <td>0.1244</td>\n",
              "      <td>-1.7090</td>\n",
              "      <td>-0.3543</td>\n",
              "      <td>-0.5160</td>\n",
              "      <td>-0.3330</td>\n",
              "      <td>-0.2685</td>\n",
              "      <td>0.7649</td>\n",
              "      <td>0.2057</td>\n",
              "      <td>1.3720</td>\n",
              "      <td>0.6835</td>\n",
              "      <td>0.8056</td>\n",
              "      <td>-0.3754</td>\n",
              "      <td>-1.2090</td>\n",
              "      <td>0.2965</td>\n",
              "      <td>-0.0712</td>\n",
              "      <td>0.6389</td>\n",
              "      <td>0.6674</td>\n",
              "      <td>-0.0783</td>\n",
              "      <td>1.1740</td>\n",
              "      <td>...</td>\n",
              "      <td>0.1535</td>\n",
              "      <td>-0.4640</td>\n",
              "      <td>-0.5943</td>\n",
              "      <td>0.3973</td>\n",
              "      <td>0.1500</td>\n",
              "      <td>0.5178</td>\n",
              "      <td>0.5159</td>\n",
              "      <td>0.6091</td>\n",
              "      <td>0.1813</td>\n",
              "      <td>-0.4249</td>\n",
              "      <td>0.7832</td>\n",
              "      <td>0.6529</td>\n",
              "      <td>0.5648</td>\n",
              "      <td>0.4817</td>\n",
              "      <td>0.0587</td>\n",
              "      <td>0.5303</td>\n",
              "      <td>0.6376</td>\n",
              "      <td>-0.3966</td>\n",
              "      <td>-1.4950</td>\n",
              "      <td>-0.9625</td>\n",
              "      <td>-0.0541</td>\n",
              "      <td>0.6273</td>\n",
              "      <td>0.4563</td>\n",
              "      <td>0.0698</td>\n",
              "      <td>0.8134</td>\n",
              "      <td>0.1924</td>\n",
              "      <td>0.6054</td>\n",
              "      <td>-0.1824</td>\n",
              "      <td>0.0042</td>\n",
              "      <td>0.0048</td>\n",
              "      <td>0.6670</td>\n",
              "      <td>1.0690</td>\n",
              "      <td>0.5523</td>\n",
              "      <td>-0.3031</td>\n",
              "      <td>0.1094</td>\n",
              "      <td>0.2885</td>\n",
              "      <td>-0.3786</td>\n",
              "      <td>0.7125</td>\n",
              "      <td>1</td>\n",
              "      <td>True</td>\n",
              "    </tr>\n",
              "  </tbody>\n",
              "</table>\n",
              "<p>5 rows × 879 columns</p>\n",
              "</div>"
            ],
            "text/plain": [
              "             id tratamento  tempo dose  ...    c-98    c-99  n_moa  ativo_moa\n",
              "0  id_000644bb2  com_droga     24   D1  ...  0.3801  0.4176      1       True\n",
              "1  id_000779bfc  com_droga     72   D1  ...  0.6077  0.7371      0      False\n",
              "2  id_000a6266a  com_droga     48   D1  ... -1.4080  0.6931      3       True\n",
              "3  id_0015fd391  com_droga     48   D1  ... -0.3876 -0.8154      0      False\n",
              "4  id_001626bd3  com_droga     72   D2  ... -0.3786  0.7125      1       True\n",
              "\n",
              "[5 rows x 879 columns]"
            ]
          },
          "metadata": {
            "tags": []
          },
          "execution_count": 14
        }
      ]
    },
    {
      "cell_type": "markdown",
      "metadata": {
        "id": "reBfjtcrpvw8"
      },
      "source": [
        "Maravilha! Conseguimos agora a junção dos nossos dados de resultados com os dados de experimentos. Agora conseguimos responder a pergunta que fizemos anteriormente. No tratamento eu ativei algum moa?"
      ]
    },
    {
      "cell_type": "markdown",
      "metadata": {
        "id": "KnP6B84IqHaE"
      },
      "source": [
        "Para fazer isso vamos utilizar o método:\n",
        "\n",
        "> Bloco com recuo\n",
        "\n"
      ]
    },
    {
      "cell_type": "code",
      "metadata": {
        "id": "rcU4LnVnkch6",
        "colab": {
          "base_uri": "https://localhost:8080/"
        },
        "outputId": "19db1e00-f807-47c0-e83f-ea89376df57d"
      },
      "source": [
        "dados_combinados.query('tratamento == \"com_controle\"' )['ativo_moa'].value_counts()"
      ],
      "execution_count": null,
      "outputs": [
        {
          "output_type": "execute_result",
          "data": {
            "text/plain": [
              "False    1866\n",
              "Name: ativo_moa, dtype: int64"
            ]
          },
          "metadata": {
            "tags": []
          },
          "execution_count": 15
        }
      ]
    },
    {
      "cell_type": "markdown",
      "metadata": {
        "id": "s4YOtp4bqfFt"
      },
      "source": [
        "E obtivemos todas as respostas com o 'false'. Isso quer dizer que com controle não tivemos nenhuma resposta de algum mecanismo de ação."
      ]
    },
    {
      "cell_type": "markdown",
      "metadata": {
        "id": "nMfh6CUruZTg"
      },
      "source": [
        "Agora, será que algum tratamento que o paciente recebeu (com_droga, nesse caso) teve alguma substância que não ativou o mecanismo de ação? Vamos responder isso com a seguinte alteração no código anterior:"
      ]
    },
    {
      "cell_type": "code",
      "metadata": {
        "id": "eyBpIF8pmBrJ",
        "colab": {
          "base_uri": "https://localhost:8080/"
        },
        "outputId": "205b4275-131b-40b9-f6ec-2715f0a2ef40"
      },
      "source": [
        "dados_combinados.query('tratamento == \"com_droga\"' )['ativo_moa'].value_counts()"
      ],
      "execution_count": null,
      "outputs": [
        {
          "output_type": "execute_result",
          "data": {
            "text/plain": [
              "True     14447\n",
              "False     7501\n",
              "Name: ativo_moa, dtype: int64"
            ]
          },
          "metadata": {
            "tags": []
          },
          "execution_count": 16
        }
      ]
    },
    {
      "cell_type": "markdown",
      "metadata": {
        "id": "RcJO5IuAuycz"
      },
      "source": [
        "Olha só, tivemos um resultado interessante. Vemos que 14447 tiveram mecanismos de ação, e aproximadamente 7500 não foram ativados. "
      ]
    },
    {
      "cell_type": "markdown",
      "metadata": {
        "id": "RT7fCu0eb3F0"
      },
      "source": [
        "Vamos fazer uma análise utilizando agora o boxplot, que gera uma imagem onde podemos identificar a mediana(linha central) e os quartis, entendendo assim como está a distribuição dos dados; dessa maneira vamos identificar, de forma visual, a comparação de categoria dos dados. Para isso vamos utilizar os seguintes códigos:"
      ]
    },
    {
      "cell_type": "code",
      "metadata": {
        "id": "AkoMHzvRHbtJ"
      },
      "source": [
        "import matplotlib.pyplot as plt\n",
        "import seaborn as sns"
      ],
      "execution_count": null,
      "outputs": []
    },
    {
      "cell_type": "code",
      "metadata": {
        "id": "qSPy0nsImdIO",
        "colab": {
          "base_uri": "https://localhost:8080/",
          "height": 514
        },
        "outputId": "3a007845-0e28-4adb-8741-ae868dff1aa8"
      },
      "source": [
        "composto_principal = dados_combinados['composto'].value_counts().index[:5]\n",
        "plt.figure(figsize=(12,8))\n",
        "sns.boxplot(data = dados_combinados.query('composto in @composto_principal'), y= 'g-0', x='composto', hue='ativo_moa')"
      ],
      "execution_count": null,
      "outputs": [
        {
          "output_type": "execute_result",
          "data": {
            "text/plain": [
              "<matplotlib.axes._subplots.AxesSubplot at 0x7f3be3fe2d10>"
            ]
          },
          "metadata": {
            "tags": []
          },
          "execution_count": 18
        },
        {
          "output_type": "display_data",
          "data": {
            "image/png": "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\n",
            "text/plain": [
              "<Figure size 864x576 with 1 Axes>"
            ]
          },
          "metadata": {
            "tags": [],
            "needs_background": "light"
          }
        }
      ]
    },
    {
      "cell_type": "markdown",
      "metadata": {
        "id": "vz5Sggy4d0AE"
      },
      "source": [
        "Analisando os boxplots, percebemos que temos algumas categorias com a mediana próxima de 0; temos outra com a mediana próxima de 5 e a outra próxima de 2.\n",
        "\n",
        "É curioso observarmos também que o 3º boxplot, da esquerda para a direita, está bem concentrado; esse composto específico é na verdade o composto que nos indica que foi \"com tratamento\".\n",
        "\n",
        "Outro ponto interessante é que o último boxplot tem um comportamento muito semelhante ao 3º; provavelmente a droga não modificou tanto assim o gene 0.\n",
        "\n",
        "Agora é com você! Faça os desafios e nos encontramos na próxima aula."
      ]
    },
    {
      "cell_type": "markdown",
      "metadata": {
        "id": "byqou37wLomb"
      },
      "source": [
        "# Retirando os Hífens das Colunas"
      ]
    },
    {
      "cell_type": "code",
      "metadata": {
        "colab": {
          "base_uri": "https://localhost:8080/",
          "height": 253
        },
        "id": "EKkIgGd-LpjF",
        "outputId": "f247615d-2a40-49b3-eb6c-3166b43e07c7"
      },
      "source": [
        "i = 0\n",
        "for i in range(len(dados_combinados.columns)):\n",
        "  dados_combinados.rename(columns = {dados_combinados.columns[i] : dados_combinados.columns[i].replace('-', '')}, inplace=True)\n",
        "\n",
        "dados_combinados.head()"
      ],
      "execution_count": null,
      "outputs": [
        {
          "output_type": "execute_result",
          "data": {
            "text/html": [
              "<div>\n",
              "<style scoped>\n",
              "    .dataframe tbody tr th:only-of-type {\n",
              "        vertical-align: middle;\n",
              "    }\n",
              "\n",
              "    .dataframe tbody tr th {\n",
              "        vertical-align: top;\n",
              "    }\n",
              "\n",
              "    .dataframe thead th {\n",
              "        text-align: right;\n",
              "    }\n",
              "</style>\n",
              "<table border=\"1\" class=\"dataframe\">\n",
              "  <thead>\n",
              "    <tr style=\"text-align: right;\">\n",
              "      <th></th>\n",
              "      <th>id</th>\n",
              "      <th>tratamento</th>\n",
              "      <th>tempo</th>\n",
              "      <th>dose</th>\n",
              "      <th>composto</th>\n",
              "      <th>g0</th>\n",
              "      <th>g1</th>\n",
              "      <th>g2</th>\n",
              "      <th>g3</th>\n",
              "      <th>g4</th>\n",
              "      <th>g5</th>\n",
              "      <th>g6</th>\n",
              "      <th>g7</th>\n",
              "      <th>g8</th>\n",
              "      <th>g9</th>\n",
              "      <th>g10</th>\n",
              "      <th>g11</th>\n",
              "      <th>g12</th>\n",
              "      <th>g13</th>\n",
              "      <th>g14</th>\n",
              "      <th>g15</th>\n",
              "      <th>g16</th>\n",
              "      <th>g17</th>\n",
              "      <th>g18</th>\n",
              "      <th>g19</th>\n",
              "      <th>g20</th>\n",
              "      <th>g21</th>\n",
              "      <th>g22</th>\n",
              "      <th>g23</th>\n",
              "      <th>g24</th>\n",
              "      <th>g25</th>\n",
              "      <th>g26</th>\n",
              "      <th>g27</th>\n",
              "      <th>g28</th>\n",
              "      <th>g29</th>\n",
              "      <th>g30</th>\n",
              "      <th>g31</th>\n",
              "      <th>g32</th>\n",
              "      <th>g33</th>\n",
              "      <th>g34</th>\n",
              "      <th>...</th>\n",
              "      <th>c62</th>\n",
              "      <th>c63</th>\n",
              "      <th>c64</th>\n",
              "      <th>c65</th>\n",
              "      <th>c66</th>\n",
              "      <th>c67</th>\n",
              "      <th>c68</th>\n",
              "      <th>c69</th>\n",
              "      <th>c70</th>\n",
              "      <th>c71</th>\n",
              "      <th>c72</th>\n",
              "      <th>c73</th>\n",
              "      <th>c74</th>\n",
              "      <th>c75</th>\n",
              "      <th>c76</th>\n",
              "      <th>c77</th>\n",
              "      <th>c78</th>\n",
              "      <th>c79</th>\n",
              "      <th>c80</th>\n",
              "      <th>c81</th>\n",
              "      <th>c82</th>\n",
              "      <th>c83</th>\n",
              "      <th>c84</th>\n",
              "      <th>c85</th>\n",
              "      <th>c86</th>\n",
              "      <th>c87</th>\n",
              "      <th>c88</th>\n",
              "      <th>c89</th>\n",
              "      <th>c90</th>\n",
              "      <th>c91</th>\n",
              "      <th>c92</th>\n",
              "      <th>c93</th>\n",
              "      <th>c94</th>\n",
              "      <th>c95</th>\n",
              "      <th>c96</th>\n",
              "      <th>c97</th>\n",
              "      <th>c98</th>\n",
              "      <th>c99</th>\n",
              "      <th>n_moa</th>\n",
              "      <th>ativo_moa</th>\n",
              "    </tr>\n",
              "  </thead>\n",
              "  <tbody>\n",
              "    <tr>\n",
              "      <th>0</th>\n",
              "      <td>id_000644bb2</td>\n",
              "      <td>com_droga</td>\n",
              "      <td>24</td>\n",
              "      <td>D1</td>\n",
              "      <td>b68db1d53</td>\n",
              "      <td>1.0620</td>\n",
              "      <td>0.5577</td>\n",
              "      <td>-0.2479</td>\n",
              "      <td>-0.6208</td>\n",
              "      <td>-0.1944</td>\n",
              "      <td>-1.0120</td>\n",
              "      <td>-1.0220</td>\n",
              "      <td>-0.0326</td>\n",
              "      <td>0.5548</td>\n",
              "      <td>-0.0921</td>\n",
              "      <td>1.1830</td>\n",
              "      <td>0.1530</td>\n",
              "      <td>0.5574</td>\n",
              "      <td>-0.4015</td>\n",
              "      <td>0.1789</td>\n",
              "      <td>-0.6528</td>\n",
              "      <td>-0.7969</td>\n",
              "      <td>0.6342</td>\n",
              "      <td>0.1778</td>\n",
              "      <td>-0.3694</td>\n",
              "      <td>-0.5688</td>\n",
              "      <td>-1.1360</td>\n",
              "      <td>-1.1880</td>\n",
              "      <td>0.6940</td>\n",
              "      <td>0.4393</td>\n",
              "      <td>0.2664</td>\n",
              "      <td>0.1907</td>\n",
              "      <td>0.1628</td>\n",
              "      <td>-0.2853</td>\n",
              "      <td>0.5819</td>\n",
              "      <td>0.2934</td>\n",
              "      <td>-0.5584</td>\n",
              "      <td>-0.0916</td>\n",
              "      <td>-0.3010</td>\n",
              "      <td>-0.1537</td>\n",
              "      <td>...</td>\n",
              "      <td>0.3680</td>\n",
              "      <td>0.8427</td>\n",
              "      <td>0.1042</td>\n",
              "      <td>0.1403</td>\n",
              "      <td>0.1758</td>\n",
              "      <td>1.2570</td>\n",
              "      <td>-0.5979</td>\n",
              "      <td>1.2250</td>\n",
              "      <td>-0.0553</td>\n",
              "      <td>0.7351</td>\n",
              "      <td>0.5810</td>\n",
              "      <td>0.9590</td>\n",
              "      <td>0.2427</td>\n",
              "      <td>0.0495</td>\n",
              "      <td>0.4141</td>\n",
              "      <td>0.8432</td>\n",
              "      <td>0.6162</td>\n",
              "      <td>-0.7318</td>\n",
              "      <td>1.2120</td>\n",
              "      <td>0.6362</td>\n",
              "      <td>-0.4427</td>\n",
              "      <td>0.1288</td>\n",
              "      <td>1.4840</td>\n",
              "      <td>0.1799</td>\n",
              "      <td>0.5367</td>\n",
              "      <td>-0.1111</td>\n",
              "      <td>-1.0120</td>\n",
              "      <td>0.6685</td>\n",
              "      <td>0.2862</td>\n",
              "      <td>0.2584</td>\n",
              "      <td>0.8076</td>\n",
              "      <td>0.5523</td>\n",
              "      <td>-0.1912</td>\n",
              "      <td>0.6584</td>\n",
              "      <td>-0.3981</td>\n",
              "      <td>0.2139</td>\n",
              "      <td>0.3801</td>\n",
              "      <td>0.4176</td>\n",
              "      <td>1</td>\n",
              "      <td>True</td>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>1</th>\n",
              "      <td>id_000779bfc</td>\n",
              "      <td>com_droga</td>\n",
              "      <td>72</td>\n",
              "      <td>D1</td>\n",
              "      <td>df89a8e5a</td>\n",
              "      <td>0.0743</td>\n",
              "      <td>0.4087</td>\n",
              "      <td>0.2991</td>\n",
              "      <td>0.0604</td>\n",
              "      <td>1.0190</td>\n",
              "      <td>0.5207</td>\n",
              "      <td>0.2341</td>\n",
              "      <td>0.3372</td>\n",
              "      <td>-0.4047</td>\n",
              "      <td>0.8507</td>\n",
              "      <td>-1.1520</td>\n",
              "      <td>-0.4201</td>\n",
              "      <td>-0.0958</td>\n",
              "      <td>0.4590</td>\n",
              "      <td>0.0803</td>\n",
              "      <td>0.2250</td>\n",
              "      <td>0.5293</td>\n",
              "      <td>0.2839</td>\n",
              "      <td>-0.3494</td>\n",
              "      <td>0.2883</td>\n",
              "      <td>0.9449</td>\n",
              "      <td>-0.1646</td>\n",
              "      <td>-0.2657</td>\n",
              "      <td>-0.3372</td>\n",
              "      <td>0.3135</td>\n",
              "      <td>-0.4316</td>\n",
              "      <td>0.4773</td>\n",
              "      <td>0.2075</td>\n",
              "      <td>-0.4216</td>\n",
              "      <td>-0.1161</td>\n",
              "      <td>-0.0499</td>\n",
              "      <td>-0.2627</td>\n",
              "      <td>0.9959</td>\n",
              "      <td>-0.2483</td>\n",
              "      <td>0.2655</td>\n",
              "      <td>...</td>\n",
              "      <td>0.3905</td>\n",
              "      <td>0.7099</td>\n",
              "      <td>0.2912</td>\n",
              "      <td>0.4151</td>\n",
              "      <td>-0.2840</td>\n",
              "      <td>-0.3104</td>\n",
              "      <td>-0.6373</td>\n",
              "      <td>0.2887</td>\n",
              "      <td>-0.0765</td>\n",
              "      <td>0.2539</td>\n",
              "      <td>0.4443</td>\n",
              "      <td>0.5932</td>\n",
              "      <td>0.2031</td>\n",
              "      <td>0.7639</td>\n",
              "      <td>0.5499</td>\n",
              "      <td>-0.3322</td>\n",
              "      <td>-0.0977</td>\n",
              "      <td>0.4329</td>\n",
              "      <td>-0.2782</td>\n",
              "      <td>0.7827</td>\n",
              "      <td>0.5934</td>\n",
              "      <td>0.3402</td>\n",
              "      <td>0.1499</td>\n",
              "      <td>0.4420</td>\n",
              "      <td>0.9366</td>\n",
              "      <td>0.8193</td>\n",
              "      <td>-0.4236</td>\n",
              "      <td>0.3192</td>\n",
              "      <td>-0.4265</td>\n",
              "      <td>0.7543</td>\n",
              "      <td>0.4708</td>\n",
              "      <td>0.0230</td>\n",
              "      <td>0.2957</td>\n",
              "      <td>0.4899</td>\n",
              "      <td>0.1522</td>\n",
              "      <td>0.1241</td>\n",
              "      <td>0.6077</td>\n",
              "      <td>0.7371</td>\n",
              "      <td>0</td>\n",
              "      <td>False</td>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>2</th>\n",
              "      <td>id_000a6266a</td>\n",
              "      <td>com_droga</td>\n",
              "      <td>48</td>\n",
              "      <td>D1</td>\n",
              "      <td>18bb41b2c</td>\n",
              "      <td>0.6280</td>\n",
              "      <td>0.5817</td>\n",
              "      <td>1.5540</td>\n",
              "      <td>-0.0764</td>\n",
              "      <td>-0.0323</td>\n",
              "      <td>1.2390</td>\n",
              "      <td>0.1715</td>\n",
              "      <td>0.2155</td>\n",
              "      <td>0.0065</td>\n",
              "      <td>1.2300</td>\n",
              "      <td>-0.4797</td>\n",
              "      <td>-0.5631</td>\n",
              "      <td>-0.0366</td>\n",
              "      <td>-1.8300</td>\n",
              "      <td>0.6057</td>\n",
              "      <td>-0.3278</td>\n",
              "      <td>0.6042</td>\n",
              "      <td>-0.3075</td>\n",
              "      <td>-0.1147</td>\n",
              "      <td>-0.0570</td>\n",
              "      <td>-0.0799</td>\n",
              "      <td>-0.8181</td>\n",
              "      <td>-1.5320</td>\n",
              "      <td>0.2307</td>\n",
              "      <td>0.4901</td>\n",
              "      <td>0.4780</td>\n",
              "      <td>-1.3970</td>\n",
              "      <td>4.6240</td>\n",
              "      <td>-0.0437</td>\n",
              "      <td>1.2870</td>\n",
              "      <td>-1.8530</td>\n",
              "      <td>0.6069</td>\n",
              "      <td>0.4290</td>\n",
              "      <td>0.1783</td>\n",
              "      <td>0.0018</td>\n",
              "      <td>...</td>\n",
              "      <td>-0.0444</td>\n",
              "      <td>0.1894</td>\n",
              "      <td>-0.0014</td>\n",
              "      <td>-2.3640</td>\n",
              "      <td>-0.4682</td>\n",
              "      <td>0.1210</td>\n",
              "      <td>-0.5177</td>\n",
              "      <td>-0.0604</td>\n",
              "      <td>0.1682</td>\n",
              "      <td>-0.4436</td>\n",
              "      <td>0.4963</td>\n",
              "      <td>0.1363</td>\n",
              "      <td>0.3335</td>\n",
              "      <td>0.9760</td>\n",
              "      <td>-0.0427</td>\n",
              "      <td>-0.1235</td>\n",
              "      <td>0.0959</td>\n",
              "      <td>0.0690</td>\n",
              "      <td>-0.9416</td>\n",
              "      <td>-0.7548</td>\n",
              "      <td>-0.1109</td>\n",
              "      <td>-0.6272</td>\n",
              "      <td>0.3019</td>\n",
              "      <td>0.1172</td>\n",
              "      <td>0.1093</td>\n",
              "      <td>-0.3113</td>\n",
              "      <td>0.3019</td>\n",
              "      <td>-0.0873</td>\n",
              "      <td>-0.7250</td>\n",
              "      <td>-0.6297</td>\n",
              "      <td>0.6103</td>\n",
              "      <td>0.0223</td>\n",
              "      <td>-1.3240</td>\n",
              "      <td>-0.3174</td>\n",
              "      <td>-0.6417</td>\n",
              "      <td>-0.2187</td>\n",
              "      <td>-1.4080</td>\n",
              "      <td>0.6931</td>\n",
              "      <td>3</td>\n",
              "      <td>True</td>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>3</th>\n",
              "      <td>id_0015fd391</td>\n",
              "      <td>com_droga</td>\n",
              "      <td>48</td>\n",
              "      <td>D1</td>\n",
              "      <td>8c7f86626</td>\n",
              "      <td>-0.5138</td>\n",
              "      <td>-0.2491</td>\n",
              "      <td>-0.2656</td>\n",
              "      <td>0.5288</td>\n",
              "      <td>4.0620</td>\n",
              "      <td>-0.8095</td>\n",
              "      <td>-1.9590</td>\n",
              "      <td>0.1792</td>\n",
              "      <td>-0.1321</td>\n",
              "      <td>-1.0600</td>\n",
              "      <td>-0.8269</td>\n",
              "      <td>-0.3584</td>\n",
              "      <td>-0.8511</td>\n",
              "      <td>-0.5844</td>\n",
              "      <td>-2.5690</td>\n",
              "      <td>0.8183</td>\n",
              "      <td>-0.0532</td>\n",
              "      <td>-0.8554</td>\n",
              "      <td>0.1160</td>\n",
              "      <td>-2.3520</td>\n",
              "      <td>2.1200</td>\n",
              "      <td>-1.1580</td>\n",
              "      <td>-0.7191</td>\n",
              "      <td>-0.8004</td>\n",
              "      <td>-1.4670</td>\n",
              "      <td>-0.0107</td>\n",
              "      <td>-0.8995</td>\n",
              "      <td>0.2406</td>\n",
              "      <td>-0.2479</td>\n",
              "      <td>-1.0890</td>\n",
              "      <td>-0.7575</td>\n",
              "      <td>0.0881</td>\n",
              "      <td>-2.7370</td>\n",
              "      <td>0.8745</td>\n",
              "      <td>0.5787</td>\n",
              "      <td>...</td>\n",
              "      <td>-2.3820</td>\n",
              "      <td>-3.7350</td>\n",
              "      <td>-2.9740</td>\n",
              "      <td>-1.4930</td>\n",
              "      <td>-1.6600</td>\n",
              "      <td>-3.1660</td>\n",
              "      <td>0.2816</td>\n",
              "      <td>-0.2990</td>\n",
              "      <td>-1.1870</td>\n",
              "      <td>-0.5044</td>\n",
              "      <td>-1.7750</td>\n",
              "      <td>-1.6120</td>\n",
              "      <td>-0.9215</td>\n",
              "      <td>-1.0810</td>\n",
              "      <td>-3.0520</td>\n",
              "      <td>-3.4470</td>\n",
              "      <td>-2.7740</td>\n",
              "      <td>-1.8460</td>\n",
              "      <td>-0.5568</td>\n",
              "      <td>-3.3960</td>\n",
              "      <td>-2.9510</td>\n",
              "      <td>-1.1550</td>\n",
              "      <td>-3.2620</td>\n",
              "      <td>-1.5390</td>\n",
              "      <td>-2.4600</td>\n",
              "      <td>-0.9417</td>\n",
              "      <td>-1.5550</td>\n",
              "      <td>0.2431</td>\n",
              "      <td>-2.0990</td>\n",
              "      <td>-0.6441</td>\n",
              "      <td>-5.6300</td>\n",
              "      <td>-1.3780</td>\n",
              "      <td>-0.8632</td>\n",
              "      <td>-1.2880</td>\n",
              "      <td>-1.6210</td>\n",
              "      <td>-0.8784</td>\n",
              "      <td>-0.3876</td>\n",
              "      <td>-0.8154</td>\n",
              "      <td>0</td>\n",
              "      <td>False</td>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>4</th>\n",
              "      <td>id_001626bd3</td>\n",
              "      <td>com_droga</td>\n",
              "      <td>72</td>\n",
              "      <td>D2</td>\n",
              "      <td>7cbed3131</td>\n",
              "      <td>-0.3254</td>\n",
              "      <td>-0.4009</td>\n",
              "      <td>0.9700</td>\n",
              "      <td>0.6919</td>\n",
              "      <td>1.4180</td>\n",
              "      <td>-0.8244</td>\n",
              "      <td>-0.2800</td>\n",
              "      <td>-0.1498</td>\n",
              "      <td>-0.8789</td>\n",
              "      <td>0.8630</td>\n",
              "      <td>-0.2219</td>\n",
              "      <td>-0.5121</td>\n",
              "      <td>-0.9577</td>\n",
              "      <td>1.1750</td>\n",
              "      <td>0.2042</td>\n",
              "      <td>0.1970</td>\n",
              "      <td>0.1244</td>\n",
              "      <td>-1.7090</td>\n",
              "      <td>-0.3543</td>\n",
              "      <td>-0.5160</td>\n",
              "      <td>-0.3330</td>\n",
              "      <td>-0.2685</td>\n",
              "      <td>0.7649</td>\n",
              "      <td>0.2057</td>\n",
              "      <td>1.3720</td>\n",
              "      <td>0.6835</td>\n",
              "      <td>0.8056</td>\n",
              "      <td>-0.3754</td>\n",
              "      <td>-1.2090</td>\n",
              "      <td>0.2965</td>\n",
              "      <td>-0.0712</td>\n",
              "      <td>0.6389</td>\n",
              "      <td>0.6674</td>\n",
              "      <td>-0.0783</td>\n",
              "      <td>1.1740</td>\n",
              "      <td>...</td>\n",
              "      <td>0.1535</td>\n",
              "      <td>-0.4640</td>\n",
              "      <td>-0.5943</td>\n",
              "      <td>0.3973</td>\n",
              "      <td>0.1500</td>\n",
              "      <td>0.5178</td>\n",
              "      <td>0.5159</td>\n",
              "      <td>0.6091</td>\n",
              "      <td>0.1813</td>\n",
              "      <td>-0.4249</td>\n",
              "      <td>0.7832</td>\n",
              "      <td>0.6529</td>\n",
              "      <td>0.5648</td>\n",
              "      <td>0.4817</td>\n",
              "      <td>0.0587</td>\n",
              "      <td>0.5303</td>\n",
              "      <td>0.6376</td>\n",
              "      <td>-0.3966</td>\n",
              "      <td>-1.4950</td>\n",
              "      <td>-0.9625</td>\n",
              "      <td>-0.0541</td>\n",
              "      <td>0.6273</td>\n",
              "      <td>0.4563</td>\n",
              "      <td>0.0698</td>\n",
              "      <td>0.8134</td>\n",
              "      <td>0.1924</td>\n",
              "      <td>0.6054</td>\n",
              "      <td>-0.1824</td>\n",
              "      <td>0.0042</td>\n",
              "      <td>0.0048</td>\n",
              "      <td>0.6670</td>\n",
              "      <td>1.0690</td>\n",
              "      <td>0.5523</td>\n",
              "      <td>-0.3031</td>\n",
              "      <td>0.1094</td>\n",
              "      <td>0.2885</td>\n",
              "      <td>-0.3786</td>\n",
              "      <td>0.7125</td>\n",
              "      <td>1</td>\n",
              "      <td>True</td>\n",
              "    </tr>\n",
              "  </tbody>\n",
              "</table>\n",
              "<p>5 rows × 879 columns</p>\n",
              "</div>"
            ],
            "text/plain": [
              "             id tratamento  tempo dose  ...     c98     c99  n_moa  ativo_moa\n",
              "0  id_000644bb2  com_droga     24   D1  ...  0.3801  0.4176      1       True\n",
              "1  id_000779bfc  com_droga     72   D1  ...  0.6077  0.7371      0      False\n",
              "2  id_000a6266a  com_droga     48   D1  ... -1.4080  0.6931      3       True\n",
              "3  id_0015fd391  com_droga     48   D1  ... -0.3876 -0.8154      0      False\n",
              "4  id_001626bd3  com_droga     72   D2  ... -0.3786  0.7125      1       True\n",
              "\n",
              "[5 rows x 879 columns]"
            ]
          },
          "metadata": {
            "tags": []
          },
          "execution_count": 19
        }
      ]
    },
    {
      "cell_type": "markdown",
      "metadata": {
        "id": "tphGNNCkIK4e"
      },
      "source": [
        "# Desafios"
      ]
    },
    {
      "cell_type": "markdown",
      "metadata": {
        "id": "X_Lg2XTu20ND"
      },
      "source": [
        "##Aula 04\n",
        "\n",
        "###Desafio 01: Encontrar o top 10, das ações do MOA (inibidor, agonista...)\n",
        "\n",
        "###Desafio 02: Criar a coluna eh_controle para quando na linha tratamento == com_controle\n",
        "\n",
        "###Desafio 03: Criar três colunas para indicar o tempo 24, 48, 72\n",
        "\n",
        "###Desafio 04: Estudar sobre combinações de DF https://pandas.pydata.org/pandas-docs/stable/user_guide/merging.html\n",
        "\n",
        "\n",
        "###Desafio 05: Fazer análise mais detalhada considerando tempo e dose, para comparar as distribuições (Escolher uma droga e comparar com controle)\n",
        "\n",
        "###Desafio 06: Descobrir se tem algum composto que dependendo da configuração do experimento, ativa ou não ativa algum MOA \n",
        "\n",
        "###Desafio 07: Descobrir se tem algum composto que dependendo da configuração do experimento, ativa MOAs diferentes\n",
        "\n",
        "\n",
        "###Desafio 08: Resumo do que você aprendeu com os dados\n"
      ]
    },
    {
      "cell_type": "markdown",
      "metadata": {
        "id": "lARw4d3rIC4t"
      },
      "source": [
        "# Trabalhando com Sklearn"
      ]
    },
    {
      "cell_type": "code",
      "metadata": {
        "id": "cv_-F9SDID3H"
      },
      "source": [
        "from sklearn import preprocessing"
      ],
      "execution_count": null,
      "outputs": []
    },
    {
      "cell_type": "markdown",
      "metadata": {
        "id": "KTyUh5X2IYBm"
      },
      "source": [
        "## Tratamento do Texto Categórico \"tratamento\""
      ]
    },
    {
      "cell_type": "code",
      "metadata": {
        "colab": {
          "base_uri": "https://localhost:8080/"
        },
        "id": "95VQ21Z8IDxt",
        "outputId": "92b06c67-85dd-4e8d-a49d-8addf40a4f23"
      },
      "source": [
        "dados_combinados['tratamento'].unique()"
      ],
      "execution_count": null,
      "outputs": [
        {
          "output_type": "execute_result",
          "data": {
            "text/plain": [
              "array(['com_droga', 'com_controle'], dtype=object)"
            ]
          },
          "metadata": {
            "tags": []
          },
          "execution_count": 21
        }
      ]
    },
    {
      "cell_type": "markdown",
      "metadata": {
        "id": "prh9LkgwJRDU"
      },
      "source": [
        "### Utilizando o \"OneHotEncoder\""
      ]
    },
    {
      "cell_type": "code",
      "metadata": {
        "colab": {
          "base_uri": "https://localhost:8080/"
        },
        "id": "duDmDpwoIDr2",
        "outputId": "ddf38de9-64eb-4708-88ac-dce34c0a35cc"
      },
      "source": [
        "ohe = preprocessing.OneHotEncoder(handle_unknown='ignore', sparse=False) # sparse=False retorna um Array\n",
        "ohe.fit(dados_combinados[['tratamento']])"
      ],
      "execution_count": null,
      "outputs": [
        {
          "output_type": "execute_result",
          "data": {
            "text/plain": [
              "OneHotEncoder(categories='auto', drop=None, dtype=<class 'numpy.float64'>,\n",
              "              handle_unknown='ignore', sparse=False)"
            ]
          },
          "metadata": {
            "tags": []
          },
          "execution_count": 22
        }
      ]
    },
    {
      "cell_type": "code",
      "metadata": {
        "colab": {
          "base_uri": "https://localhost:8080/"
        },
        "id": "Azw9TOkBIDUw",
        "outputId": "9eb6e241-c85d-4b22-f958-676057a5cc3f"
      },
      "source": [
        "ohe.get_feature_names(['tratamento'])"
      ],
      "execution_count": null,
      "outputs": [
        {
          "output_type": "execute_result",
          "data": {
            "text/plain": [
              "array(['tratamento_com_controle', 'tratamento_com_droga'], dtype=object)"
            ]
          },
          "metadata": {
            "tags": []
          },
          "execution_count": 23
        }
      ]
    },
    {
      "cell_type": "code",
      "metadata": {
        "colab": {
          "base_uri": "https://localhost:8080/",
          "height": 419
        },
        "id": "1GCXDdVEJpor",
        "outputId": "cba4ec76-429d-43cd-f65d-1634ea42fd01"
      },
      "source": [
        "# Retorna um Array (Matriz) com uma coluna numérica para cada tratamento\n",
        "X = ohe.transform(dados_combinados[['tratamento']])\n",
        "\n",
        "dados_numericos = pd.DataFrame(X, columns=ohe.get_feature_names(['tratamento']))\n",
        "dados_numericos"
      ],
      "execution_count": null,
      "outputs": [
        {
          "output_type": "execute_result",
          "data": {
            "text/html": [
              "<div>\n",
              "<style scoped>\n",
              "    .dataframe tbody tr th:only-of-type {\n",
              "        vertical-align: middle;\n",
              "    }\n",
              "\n",
              "    .dataframe tbody tr th {\n",
              "        vertical-align: top;\n",
              "    }\n",
              "\n",
              "    .dataframe thead th {\n",
              "        text-align: right;\n",
              "    }\n",
              "</style>\n",
              "<table border=\"1\" class=\"dataframe\">\n",
              "  <thead>\n",
              "    <tr style=\"text-align: right;\">\n",
              "      <th></th>\n",
              "      <th>tratamento_com_controle</th>\n",
              "      <th>tratamento_com_droga</th>\n",
              "    </tr>\n",
              "  </thead>\n",
              "  <tbody>\n",
              "    <tr>\n",
              "      <th>0</th>\n",
              "      <td>0.0</td>\n",
              "      <td>1.0</td>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>1</th>\n",
              "      <td>0.0</td>\n",
              "      <td>1.0</td>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>2</th>\n",
              "      <td>0.0</td>\n",
              "      <td>1.0</td>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>3</th>\n",
              "      <td>0.0</td>\n",
              "      <td>1.0</td>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>4</th>\n",
              "      <td>0.0</td>\n",
              "      <td>1.0</td>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>...</th>\n",
              "      <td>...</td>\n",
              "      <td>...</td>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>23809</th>\n",
              "      <td>0.0</td>\n",
              "      <td>1.0</td>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>23810</th>\n",
              "      <td>0.0</td>\n",
              "      <td>1.0</td>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>23811</th>\n",
              "      <td>1.0</td>\n",
              "      <td>0.0</td>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>23812</th>\n",
              "      <td>0.0</td>\n",
              "      <td>1.0</td>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>23813</th>\n",
              "      <td>0.0</td>\n",
              "      <td>1.0</td>\n",
              "    </tr>\n",
              "  </tbody>\n",
              "</table>\n",
              "<p>23814 rows × 2 columns</p>\n",
              "</div>"
            ],
            "text/plain": [
              "       tratamento_com_controle  tratamento_com_droga\n",
              "0                          0.0                   1.0\n",
              "1                          0.0                   1.0\n",
              "2                          0.0                   1.0\n",
              "3                          0.0                   1.0\n",
              "4                          0.0                   1.0\n",
              "...                        ...                   ...\n",
              "23809                      0.0                   1.0\n",
              "23810                      0.0                   1.0\n",
              "23811                      1.0                   0.0\n",
              "23812                      0.0                   1.0\n",
              "23813                      0.0                   1.0\n",
              "\n",
              "[23814 rows x 2 columns]"
            ]
          },
          "metadata": {
            "tags": []
          },
          "execution_count": 24
        }
      ]
    },
    {
      "cell_type": "markdown",
      "metadata": {
        "id": "rdzKQQf3KS5b"
      },
      "source": [
        "### Deletando a Coluna Original \"tratamento\""
      ]
    },
    {
      "cell_type": "code",
      "metadata": {
        "colab": {
          "base_uri": "https://localhost:8080/",
          "height": 160
        },
        "id": "cbikRuKQKGXU",
        "outputId": "be07cc36-d19f-4c04-dfbe-543d5da7d63d"
      },
      "source": [
        "dados_combinados = dados_combinados.drop(['tratamento'], axis=1)\n",
        "dados_combinados.head(2)"
      ],
      "execution_count": null,
      "outputs": [
        {
          "output_type": "execute_result",
          "data": {
            "text/html": [
              "<div>\n",
              "<style scoped>\n",
              "    .dataframe tbody tr th:only-of-type {\n",
              "        vertical-align: middle;\n",
              "    }\n",
              "\n",
              "    .dataframe tbody tr th {\n",
              "        vertical-align: top;\n",
              "    }\n",
              "\n",
              "    .dataframe thead th {\n",
              "        text-align: right;\n",
              "    }\n",
              "</style>\n",
              "<table border=\"1\" class=\"dataframe\">\n",
              "  <thead>\n",
              "    <tr style=\"text-align: right;\">\n",
              "      <th></th>\n",
              "      <th>id</th>\n",
              "      <th>tempo</th>\n",
              "      <th>dose</th>\n",
              "      <th>composto</th>\n",
              "      <th>g0</th>\n",
              "      <th>g1</th>\n",
              "      <th>g2</th>\n",
              "      <th>g3</th>\n",
              "      <th>g4</th>\n",
              "      <th>g5</th>\n",
              "      <th>g6</th>\n",
              "      <th>g7</th>\n",
              "      <th>g8</th>\n",
              "      <th>g9</th>\n",
              "      <th>g10</th>\n",
              "      <th>g11</th>\n",
              "      <th>g12</th>\n",
              "      <th>g13</th>\n",
              "      <th>g14</th>\n",
              "      <th>g15</th>\n",
              "      <th>g16</th>\n",
              "      <th>g17</th>\n",
              "      <th>g18</th>\n",
              "      <th>g19</th>\n",
              "      <th>g20</th>\n",
              "      <th>g21</th>\n",
              "      <th>g22</th>\n",
              "      <th>g23</th>\n",
              "      <th>g24</th>\n",
              "      <th>g25</th>\n",
              "      <th>g26</th>\n",
              "      <th>g27</th>\n",
              "      <th>g28</th>\n",
              "      <th>g29</th>\n",
              "      <th>g30</th>\n",
              "      <th>g31</th>\n",
              "      <th>g32</th>\n",
              "      <th>g33</th>\n",
              "      <th>g34</th>\n",
              "      <th>g35</th>\n",
              "      <th>...</th>\n",
              "      <th>c62</th>\n",
              "      <th>c63</th>\n",
              "      <th>c64</th>\n",
              "      <th>c65</th>\n",
              "      <th>c66</th>\n",
              "      <th>c67</th>\n",
              "      <th>c68</th>\n",
              "      <th>c69</th>\n",
              "      <th>c70</th>\n",
              "      <th>c71</th>\n",
              "      <th>c72</th>\n",
              "      <th>c73</th>\n",
              "      <th>c74</th>\n",
              "      <th>c75</th>\n",
              "      <th>c76</th>\n",
              "      <th>c77</th>\n",
              "      <th>c78</th>\n",
              "      <th>c79</th>\n",
              "      <th>c80</th>\n",
              "      <th>c81</th>\n",
              "      <th>c82</th>\n",
              "      <th>c83</th>\n",
              "      <th>c84</th>\n",
              "      <th>c85</th>\n",
              "      <th>c86</th>\n",
              "      <th>c87</th>\n",
              "      <th>c88</th>\n",
              "      <th>c89</th>\n",
              "      <th>c90</th>\n",
              "      <th>c91</th>\n",
              "      <th>c92</th>\n",
              "      <th>c93</th>\n",
              "      <th>c94</th>\n",
              "      <th>c95</th>\n",
              "      <th>c96</th>\n",
              "      <th>c97</th>\n",
              "      <th>c98</th>\n",
              "      <th>c99</th>\n",
              "      <th>n_moa</th>\n",
              "      <th>ativo_moa</th>\n",
              "    </tr>\n",
              "  </thead>\n",
              "  <tbody>\n",
              "    <tr>\n",
              "      <th>0</th>\n",
              "      <td>id_000644bb2</td>\n",
              "      <td>24</td>\n",
              "      <td>D1</td>\n",
              "      <td>b68db1d53</td>\n",
              "      <td>1.0620</td>\n",
              "      <td>0.5577</td>\n",
              "      <td>-0.2479</td>\n",
              "      <td>-0.6208</td>\n",
              "      <td>-0.1944</td>\n",
              "      <td>-1.0120</td>\n",
              "      <td>-1.0220</td>\n",
              "      <td>-0.0326</td>\n",
              "      <td>0.5548</td>\n",
              "      <td>-0.0921</td>\n",
              "      <td>1.183</td>\n",
              "      <td>0.1530</td>\n",
              "      <td>0.5574</td>\n",
              "      <td>-0.4015</td>\n",
              "      <td>0.1789</td>\n",
              "      <td>-0.6528</td>\n",
              "      <td>-0.7969</td>\n",
              "      <td>0.6342</td>\n",
              "      <td>0.1778</td>\n",
              "      <td>-0.3694</td>\n",
              "      <td>-0.5688</td>\n",
              "      <td>-1.1360</td>\n",
              "      <td>-1.1880</td>\n",
              "      <td>0.6940</td>\n",
              "      <td>0.4393</td>\n",
              "      <td>0.2664</td>\n",
              "      <td>0.1907</td>\n",
              "      <td>0.1628</td>\n",
              "      <td>-0.2853</td>\n",
              "      <td>0.5819</td>\n",
              "      <td>0.2934</td>\n",
              "      <td>-0.5584</td>\n",
              "      <td>-0.0916</td>\n",
              "      <td>-0.3010</td>\n",
              "      <td>-0.1537</td>\n",
              "      <td>0.2198</td>\n",
              "      <td>...</td>\n",
              "      <td>0.3680</td>\n",
              "      <td>0.8427</td>\n",
              "      <td>0.1042</td>\n",
              "      <td>0.1403</td>\n",
              "      <td>0.1758</td>\n",
              "      <td>1.2570</td>\n",
              "      <td>-0.5979</td>\n",
              "      <td>1.2250</td>\n",
              "      <td>-0.0553</td>\n",
              "      <td>0.7351</td>\n",
              "      <td>0.5810</td>\n",
              "      <td>0.9590</td>\n",
              "      <td>0.2427</td>\n",
              "      <td>0.0495</td>\n",
              "      <td>0.4141</td>\n",
              "      <td>0.8432</td>\n",
              "      <td>0.6162</td>\n",
              "      <td>-0.7318</td>\n",
              "      <td>1.2120</td>\n",
              "      <td>0.6362</td>\n",
              "      <td>-0.4427</td>\n",
              "      <td>0.1288</td>\n",
              "      <td>1.4840</td>\n",
              "      <td>0.1799</td>\n",
              "      <td>0.5367</td>\n",
              "      <td>-0.1111</td>\n",
              "      <td>-1.0120</td>\n",
              "      <td>0.6685</td>\n",
              "      <td>0.2862</td>\n",
              "      <td>0.2584</td>\n",
              "      <td>0.8076</td>\n",
              "      <td>0.5523</td>\n",
              "      <td>-0.1912</td>\n",
              "      <td>0.6584</td>\n",
              "      <td>-0.3981</td>\n",
              "      <td>0.2139</td>\n",
              "      <td>0.3801</td>\n",
              "      <td>0.4176</td>\n",
              "      <td>1</td>\n",
              "      <td>True</td>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>1</th>\n",
              "      <td>id_000779bfc</td>\n",
              "      <td>72</td>\n",
              "      <td>D1</td>\n",
              "      <td>df89a8e5a</td>\n",
              "      <td>0.0743</td>\n",
              "      <td>0.4087</td>\n",
              "      <td>0.2991</td>\n",
              "      <td>0.0604</td>\n",
              "      <td>1.0190</td>\n",
              "      <td>0.5207</td>\n",
              "      <td>0.2341</td>\n",
              "      <td>0.3372</td>\n",
              "      <td>-0.4047</td>\n",
              "      <td>0.8507</td>\n",
              "      <td>-1.152</td>\n",
              "      <td>-0.4201</td>\n",
              "      <td>-0.0958</td>\n",
              "      <td>0.4590</td>\n",
              "      <td>0.0803</td>\n",
              "      <td>0.2250</td>\n",
              "      <td>0.5293</td>\n",
              "      <td>0.2839</td>\n",
              "      <td>-0.3494</td>\n",
              "      <td>0.2883</td>\n",
              "      <td>0.9449</td>\n",
              "      <td>-0.1646</td>\n",
              "      <td>-0.2657</td>\n",
              "      <td>-0.3372</td>\n",
              "      <td>0.3135</td>\n",
              "      <td>-0.4316</td>\n",
              "      <td>0.4773</td>\n",
              "      <td>0.2075</td>\n",
              "      <td>-0.4216</td>\n",
              "      <td>-0.1161</td>\n",
              "      <td>-0.0499</td>\n",
              "      <td>-0.2627</td>\n",
              "      <td>0.9959</td>\n",
              "      <td>-0.2483</td>\n",
              "      <td>0.2655</td>\n",
              "      <td>-0.2102</td>\n",
              "      <td>...</td>\n",
              "      <td>0.3905</td>\n",
              "      <td>0.7099</td>\n",
              "      <td>0.2912</td>\n",
              "      <td>0.4151</td>\n",
              "      <td>-0.2840</td>\n",
              "      <td>-0.3104</td>\n",
              "      <td>-0.6373</td>\n",
              "      <td>0.2887</td>\n",
              "      <td>-0.0765</td>\n",
              "      <td>0.2539</td>\n",
              "      <td>0.4443</td>\n",
              "      <td>0.5932</td>\n",
              "      <td>0.2031</td>\n",
              "      <td>0.7639</td>\n",
              "      <td>0.5499</td>\n",
              "      <td>-0.3322</td>\n",
              "      <td>-0.0977</td>\n",
              "      <td>0.4329</td>\n",
              "      <td>-0.2782</td>\n",
              "      <td>0.7827</td>\n",
              "      <td>0.5934</td>\n",
              "      <td>0.3402</td>\n",
              "      <td>0.1499</td>\n",
              "      <td>0.4420</td>\n",
              "      <td>0.9366</td>\n",
              "      <td>0.8193</td>\n",
              "      <td>-0.4236</td>\n",
              "      <td>0.3192</td>\n",
              "      <td>-0.4265</td>\n",
              "      <td>0.7543</td>\n",
              "      <td>0.4708</td>\n",
              "      <td>0.0230</td>\n",
              "      <td>0.2957</td>\n",
              "      <td>0.4899</td>\n",
              "      <td>0.1522</td>\n",
              "      <td>0.1241</td>\n",
              "      <td>0.6077</td>\n",
              "      <td>0.7371</td>\n",
              "      <td>0</td>\n",
              "      <td>False</td>\n",
              "    </tr>\n",
              "  </tbody>\n",
              "</table>\n",
              "<p>2 rows × 878 columns</p>\n",
              "</div>"
            ],
            "text/plain": [
              "             id  tempo dose   composto  ...     c98     c99  n_moa  ativo_moa\n",
              "0  id_000644bb2     24   D1  b68db1d53  ...  0.3801  0.4176      1       True\n",
              "1  id_000779bfc     72   D1  df89a8e5a  ...  0.6077  0.7371      0      False\n",
              "\n",
              "[2 rows x 878 columns]"
            ]
          },
          "metadata": {
            "tags": []
          },
          "execution_count": 25
        }
      ]
    },
    {
      "cell_type": "markdown",
      "metadata": {
        "id": "myBejt5_KjNs"
      },
      "source": [
        "### Concatenando os DataFrames"
      ]
    },
    {
      "cell_type": "code",
      "metadata": {
        "colab": {
          "base_uri": "https://localhost:8080/",
          "height": 253
        },
        "id": "sPNqRfmXKg3t",
        "outputId": "a28fc184-2fad-40e6-d984-8defd449d3c0"
      },
      "source": [
        "dados_combinados = pd.concat([dados_combinados, dados_numericos], axis=1)\n",
        "dados_combinados.head()"
      ],
      "execution_count": null,
      "outputs": [
        {
          "output_type": "execute_result",
          "data": {
            "text/html": [
              "<div>\n",
              "<style scoped>\n",
              "    .dataframe tbody tr th:only-of-type {\n",
              "        vertical-align: middle;\n",
              "    }\n",
              "\n",
              "    .dataframe tbody tr th {\n",
              "        vertical-align: top;\n",
              "    }\n",
              "\n",
              "    .dataframe thead th {\n",
              "        text-align: right;\n",
              "    }\n",
              "</style>\n",
              "<table border=\"1\" class=\"dataframe\">\n",
              "  <thead>\n",
              "    <tr style=\"text-align: right;\">\n",
              "      <th></th>\n",
              "      <th>id</th>\n",
              "      <th>tempo</th>\n",
              "      <th>dose</th>\n",
              "      <th>composto</th>\n",
              "      <th>g0</th>\n",
              "      <th>g1</th>\n",
              "      <th>g2</th>\n",
              "      <th>g3</th>\n",
              "      <th>g4</th>\n",
              "      <th>g5</th>\n",
              "      <th>g6</th>\n",
              "      <th>g7</th>\n",
              "      <th>g8</th>\n",
              "      <th>g9</th>\n",
              "      <th>g10</th>\n",
              "      <th>g11</th>\n",
              "      <th>g12</th>\n",
              "      <th>g13</th>\n",
              "      <th>g14</th>\n",
              "      <th>g15</th>\n",
              "      <th>g16</th>\n",
              "      <th>g17</th>\n",
              "      <th>g18</th>\n",
              "      <th>g19</th>\n",
              "      <th>g20</th>\n",
              "      <th>g21</th>\n",
              "      <th>g22</th>\n",
              "      <th>g23</th>\n",
              "      <th>g24</th>\n",
              "      <th>g25</th>\n",
              "      <th>g26</th>\n",
              "      <th>g27</th>\n",
              "      <th>g28</th>\n",
              "      <th>g29</th>\n",
              "      <th>g30</th>\n",
              "      <th>g31</th>\n",
              "      <th>g32</th>\n",
              "      <th>g33</th>\n",
              "      <th>g34</th>\n",
              "      <th>g35</th>\n",
              "      <th>...</th>\n",
              "      <th>c64</th>\n",
              "      <th>c65</th>\n",
              "      <th>c66</th>\n",
              "      <th>c67</th>\n",
              "      <th>c68</th>\n",
              "      <th>c69</th>\n",
              "      <th>c70</th>\n",
              "      <th>c71</th>\n",
              "      <th>c72</th>\n",
              "      <th>c73</th>\n",
              "      <th>c74</th>\n",
              "      <th>c75</th>\n",
              "      <th>c76</th>\n",
              "      <th>c77</th>\n",
              "      <th>c78</th>\n",
              "      <th>c79</th>\n",
              "      <th>c80</th>\n",
              "      <th>c81</th>\n",
              "      <th>c82</th>\n",
              "      <th>c83</th>\n",
              "      <th>c84</th>\n",
              "      <th>c85</th>\n",
              "      <th>c86</th>\n",
              "      <th>c87</th>\n",
              "      <th>c88</th>\n",
              "      <th>c89</th>\n",
              "      <th>c90</th>\n",
              "      <th>c91</th>\n",
              "      <th>c92</th>\n",
              "      <th>c93</th>\n",
              "      <th>c94</th>\n",
              "      <th>c95</th>\n",
              "      <th>c96</th>\n",
              "      <th>c97</th>\n",
              "      <th>c98</th>\n",
              "      <th>c99</th>\n",
              "      <th>n_moa</th>\n",
              "      <th>ativo_moa</th>\n",
              "      <th>tratamento_com_controle</th>\n",
              "      <th>tratamento_com_droga</th>\n",
              "    </tr>\n",
              "  </thead>\n",
              "  <tbody>\n",
              "    <tr>\n",
              "      <th>0</th>\n",
              "      <td>id_000644bb2</td>\n",
              "      <td>24</td>\n",
              "      <td>D1</td>\n",
              "      <td>b68db1d53</td>\n",
              "      <td>1.0620</td>\n",
              "      <td>0.5577</td>\n",
              "      <td>-0.2479</td>\n",
              "      <td>-0.6208</td>\n",
              "      <td>-0.1944</td>\n",
              "      <td>-1.0120</td>\n",
              "      <td>-1.0220</td>\n",
              "      <td>-0.0326</td>\n",
              "      <td>0.5548</td>\n",
              "      <td>-0.0921</td>\n",
              "      <td>1.1830</td>\n",
              "      <td>0.1530</td>\n",
              "      <td>0.5574</td>\n",
              "      <td>-0.4015</td>\n",
              "      <td>0.1789</td>\n",
              "      <td>-0.6528</td>\n",
              "      <td>-0.7969</td>\n",
              "      <td>0.6342</td>\n",
              "      <td>0.1778</td>\n",
              "      <td>-0.3694</td>\n",
              "      <td>-0.5688</td>\n",
              "      <td>-1.1360</td>\n",
              "      <td>-1.1880</td>\n",
              "      <td>0.6940</td>\n",
              "      <td>0.4393</td>\n",
              "      <td>0.2664</td>\n",
              "      <td>0.1907</td>\n",
              "      <td>0.1628</td>\n",
              "      <td>-0.2853</td>\n",
              "      <td>0.5819</td>\n",
              "      <td>0.2934</td>\n",
              "      <td>-0.5584</td>\n",
              "      <td>-0.0916</td>\n",
              "      <td>-0.3010</td>\n",
              "      <td>-0.1537</td>\n",
              "      <td>0.2198</td>\n",
              "      <td>...</td>\n",
              "      <td>0.1042</td>\n",
              "      <td>0.1403</td>\n",
              "      <td>0.1758</td>\n",
              "      <td>1.2570</td>\n",
              "      <td>-0.5979</td>\n",
              "      <td>1.2250</td>\n",
              "      <td>-0.0553</td>\n",
              "      <td>0.7351</td>\n",
              "      <td>0.5810</td>\n",
              "      <td>0.9590</td>\n",
              "      <td>0.2427</td>\n",
              "      <td>0.0495</td>\n",
              "      <td>0.4141</td>\n",
              "      <td>0.8432</td>\n",
              "      <td>0.6162</td>\n",
              "      <td>-0.7318</td>\n",
              "      <td>1.2120</td>\n",
              "      <td>0.6362</td>\n",
              "      <td>-0.4427</td>\n",
              "      <td>0.1288</td>\n",
              "      <td>1.4840</td>\n",
              "      <td>0.1799</td>\n",
              "      <td>0.5367</td>\n",
              "      <td>-0.1111</td>\n",
              "      <td>-1.0120</td>\n",
              "      <td>0.6685</td>\n",
              "      <td>0.2862</td>\n",
              "      <td>0.2584</td>\n",
              "      <td>0.8076</td>\n",
              "      <td>0.5523</td>\n",
              "      <td>-0.1912</td>\n",
              "      <td>0.6584</td>\n",
              "      <td>-0.3981</td>\n",
              "      <td>0.2139</td>\n",
              "      <td>0.3801</td>\n",
              "      <td>0.4176</td>\n",
              "      <td>1</td>\n",
              "      <td>True</td>\n",
              "      <td>0.0</td>\n",
              "      <td>1.0</td>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>1</th>\n",
              "      <td>id_000779bfc</td>\n",
              "      <td>72</td>\n",
              "      <td>D1</td>\n",
              "      <td>df89a8e5a</td>\n",
              "      <td>0.0743</td>\n",
              "      <td>0.4087</td>\n",
              "      <td>0.2991</td>\n",
              "      <td>0.0604</td>\n",
              "      <td>1.0190</td>\n",
              "      <td>0.5207</td>\n",
              "      <td>0.2341</td>\n",
              "      <td>0.3372</td>\n",
              "      <td>-0.4047</td>\n",
              "      <td>0.8507</td>\n",
              "      <td>-1.1520</td>\n",
              "      <td>-0.4201</td>\n",
              "      <td>-0.0958</td>\n",
              "      <td>0.4590</td>\n",
              "      <td>0.0803</td>\n",
              "      <td>0.2250</td>\n",
              "      <td>0.5293</td>\n",
              "      <td>0.2839</td>\n",
              "      <td>-0.3494</td>\n",
              "      <td>0.2883</td>\n",
              "      <td>0.9449</td>\n",
              "      <td>-0.1646</td>\n",
              "      <td>-0.2657</td>\n",
              "      <td>-0.3372</td>\n",
              "      <td>0.3135</td>\n",
              "      <td>-0.4316</td>\n",
              "      <td>0.4773</td>\n",
              "      <td>0.2075</td>\n",
              "      <td>-0.4216</td>\n",
              "      <td>-0.1161</td>\n",
              "      <td>-0.0499</td>\n",
              "      <td>-0.2627</td>\n",
              "      <td>0.9959</td>\n",
              "      <td>-0.2483</td>\n",
              "      <td>0.2655</td>\n",
              "      <td>-0.2102</td>\n",
              "      <td>...</td>\n",
              "      <td>0.2912</td>\n",
              "      <td>0.4151</td>\n",
              "      <td>-0.2840</td>\n",
              "      <td>-0.3104</td>\n",
              "      <td>-0.6373</td>\n",
              "      <td>0.2887</td>\n",
              "      <td>-0.0765</td>\n",
              "      <td>0.2539</td>\n",
              "      <td>0.4443</td>\n",
              "      <td>0.5932</td>\n",
              "      <td>0.2031</td>\n",
              "      <td>0.7639</td>\n",
              "      <td>0.5499</td>\n",
              "      <td>-0.3322</td>\n",
              "      <td>-0.0977</td>\n",
              "      <td>0.4329</td>\n",
              "      <td>-0.2782</td>\n",
              "      <td>0.7827</td>\n",
              "      <td>0.5934</td>\n",
              "      <td>0.3402</td>\n",
              "      <td>0.1499</td>\n",
              "      <td>0.4420</td>\n",
              "      <td>0.9366</td>\n",
              "      <td>0.8193</td>\n",
              "      <td>-0.4236</td>\n",
              "      <td>0.3192</td>\n",
              "      <td>-0.4265</td>\n",
              "      <td>0.7543</td>\n",
              "      <td>0.4708</td>\n",
              "      <td>0.0230</td>\n",
              "      <td>0.2957</td>\n",
              "      <td>0.4899</td>\n",
              "      <td>0.1522</td>\n",
              "      <td>0.1241</td>\n",
              "      <td>0.6077</td>\n",
              "      <td>0.7371</td>\n",
              "      <td>0</td>\n",
              "      <td>False</td>\n",
              "      <td>0.0</td>\n",
              "      <td>1.0</td>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>2</th>\n",
              "      <td>id_000a6266a</td>\n",
              "      <td>48</td>\n",
              "      <td>D1</td>\n",
              "      <td>18bb41b2c</td>\n",
              "      <td>0.6280</td>\n",
              "      <td>0.5817</td>\n",
              "      <td>1.5540</td>\n",
              "      <td>-0.0764</td>\n",
              "      <td>-0.0323</td>\n",
              "      <td>1.2390</td>\n",
              "      <td>0.1715</td>\n",
              "      <td>0.2155</td>\n",
              "      <td>0.0065</td>\n",
              "      <td>1.2300</td>\n",
              "      <td>-0.4797</td>\n",
              "      <td>-0.5631</td>\n",
              "      <td>-0.0366</td>\n",
              "      <td>-1.8300</td>\n",
              "      <td>0.6057</td>\n",
              "      <td>-0.3278</td>\n",
              "      <td>0.6042</td>\n",
              "      <td>-0.3075</td>\n",
              "      <td>-0.1147</td>\n",
              "      <td>-0.0570</td>\n",
              "      <td>-0.0799</td>\n",
              "      <td>-0.8181</td>\n",
              "      <td>-1.5320</td>\n",
              "      <td>0.2307</td>\n",
              "      <td>0.4901</td>\n",
              "      <td>0.4780</td>\n",
              "      <td>-1.3970</td>\n",
              "      <td>4.6240</td>\n",
              "      <td>-0.0437</td>\n",
              "      <td>1.2870</td>\n",
              "      <td>-1.8530</td>\n",
              "      <td>0.6069</td>\n",
              "      <td>0.4290</td>\n",
              "      <td>0.1783</td>\n",
              "      <td>0.0018</td>\n",
              "      <td>-1.1800</td>\n",
              "      <td>...</td>\n",
              "      <td>-0.0014</td>\n",
              "      <td>-2.3640</td>\n",
              "      <td>-0.4682</td>\n",
              "      <td>0.1210</td>\n",
              "      <td>-0.5177</td>\n",
              "      <td>-0.0604</td>\n",
              "      <td>0.1682</td>\n",
              "      <td>-0.4436</td>\n",
              "      <td>0.4963</td>\n",
              "      <td>0.1363</td>\n",
              "      <td>0.3335</td>\n",
              "      <td>0.9760</td>\n",
              "      <td>-0.0427</td>\n",
              "      <td>-0.1235</td>\n",
              "      <td>0.0959</td>\n",
              "      <td>0.0690</td>\n",
              "      <td>-0.9416</td>\n",
              "      <td>-0.7548</td>\n",
              "      <td>-0.1109</td>\n",
              "      <td>-0.6272</td>\n",
              "      <td>0.3019</td>\n",
              "      <td>0.1172</td>\n",
              "      <td>0.1093</td>\n",
              "      <td>-0.3113</td>\n",
              "      <td>0.3019</td>\n",
              "      <td>-0.0873</td>\n",
              "      <td>-0.7250</td>\n",
              "      <td>-0.6297</td>\n",
              "      <td>0.6103</td>\n",
              "      <td>0.0223</td>\n",
              "      <td>-1.3240</td>\n",
              "      <td>-0.3174</td>\n",
              "      <td>-0.6417</td>\n",
              "      <td>-0.2187</td>\n",
              "      <td>-1.4080</td>\n",
              "      <td>0.6931</td>\n",
              "      <td>3</td>\n",
              "      <td>True</td>\n",
              "      <td>0.0</td>\n",
              "      <td>1.0</td>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>3</th>\n",
              "      <td>id_0015fd391</td>\n",
              "      <td>48</td>\n",
              "      <td>D1</td>\n",
              "      <td>8c7f86626</td>\n",
              "      <td>-0.5138</td>\n",
              "      <td>-0.2491</td>\n",
              "      <td>-0.2656</td>\n",
              "      <td>0.5288</td>\n",
              "      <td>4.0620</td>\n",
              "      <td>-0.8095</td>\n",
              "      <td>-1.9590</td>\n",
              "      <td>0.1792</td>\n",
              "      <td>-0.1321</td>\n",
              "      <td>-1.0600</td>\n",
              "      <td>-0.8269</td>\n",
              "      <td>-0.3584</td>\n",
              "      <td>-0.8511</td>\n",
              "      <td>-0.5844</td>\n",
              "      <td>-2.5690</td>\n",
              "      <td>0.8183</td>\n",
              "      <td>-0.0532</td>\n",
              "      <td>-0.8554</td>\n",
              "      <td>0.1160</td>\n",
              "      <td>-2.3520</td>\n",
              "      <td>2.1200</td>\n",
              "      <td>-1.1580</td>\n",
              "      <td>-0.7191</td>\n",
              "      <td>-0.8004</td>\n",
              "      <td>-1.4670</td>\n",
              "      <td>-0.0107</td>\n",
              "      <td>-0.8995</td>\n",
              "      <td>0.2406</td>\n",
              "      <td>-0.2479</td>\n",
              "      <td>-1.0890</td>\n",
              "      <td>-0.7575</td>\n",
              "      <td>0.0881</td>\n",
              "      <td>-2.7370</td>\n",
              "      <td>0.8745</td>\n",
              "      <td>0.5787</td>\n",
              "      <td>-1.6740</td>\n",
              "      <td>...</td>\n",
              "      <td>-2.9740</td>\n",
              "      <td>-1.4930</td>\n",
              "      <td>-1.6600</td>\n",
              "      <td>-3.1660</td>\n",
              "      <td>0.2816</td>\n",
              "      <td>-0.2990</td>\n",
              "      <td>-1.1870</td>\n",
              "      <td>-0.5044</td>\n",
              "      <td>-1.7750</td>\n",
              "      <td>-1.6120</td>\n",
              "      <td>-0.9215</td>\n",
              "      <td>-1.0810</td>\n",
              "      <td>-3.0520</td>\n",
              "      <td>-3.4470</td>\n",
              "      <td>-2.7740</td>\n",
              "      <td>-1.8460</td>\n",
              "      <td>-0.5568</td>\n",
              "      <td>-3.3960</td>\n",
              "      <td>-2.9510</td>\n",
              "      <td>-1.1550</td>\n",
              "      <td>-3.2620</td>\n",
              "      <td>-1.5390</td>\n",
              "      <td>-2.4600</td>\n",
              "      <td>-0.9417</td>\n",
              "      <td>-1.5550</td>\n",
              "      <td>0.2431</td>\n",
              "      <td>-2.0990</td>\n",
              "      <td>-0.6441</td>\n",
              "      <td>-5.6300</td>\n",
              "      <td>-1.3780</td>\n",
              "      <td>-0.8632</td>\n",
              "      <td>-1.2880</td>\n",
              "      <td>-1.6210</td>\n",
              "      <td>-0.8784</td>\n",
              "      <td>-0.3876</td>\n",
              "      <td>-0.8154</td>\n",
              "      <td>0</td>\n",
              "      <td>False</td>\n",
              "      <td>0.0</td>\n",
              "      <td>1.0</td>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>4</th>\n",
              "      <td>id_001626bd3</td>\n",
              "      <td>72</td>\n",
              "      <td>D2</td>\n",
              "      <td>7cbed3131</td>\n",
              "      <td>-0.3254</td>\n",
              "      <td>-0.4009</td>\n",
              "      <td>0.9700</td>\n",
              "      <td>0.6919</td>\n",
              "      <td>1.4180</td>\n",
              "      <td>-0.8244</td>\n",
              "      <td>-0.2800</td>\n",
              "      <td>-0.1498</td>\n",
              "      <td>-0.8789</td>\n",
              "      <td>0.8630</td>\n",
              "      <td>-0.2219</td>\n",
              "      <td>-0.5121</td>\n",
              "      <td>-0.9577</td>\n",
              "      <td>1.1750</td>\n",
              "      <td>0.2042</td>\n",
              "      <td>0.1970</td>\n",
              "      <td>0.1244</td>\n",
              "      <td>-1.7090</td>\n",
              "      <td>-0.3543</td>\n",
              "      <td>-0.5160</td>\n",
              "      <td>-0.3330</td>\n",
              "      <td>-0.2685</td>\n",
              "      <td>0.7649</td>\n",
              "      <td>0.2057</td>\n",
              "      <td>1.3720</td>\n",
              "      <td>0.6835</td>\n",
              "      <td>0.8056</td>\n",
              "      <td>-0.3754</td>\n",
              "      <td>-1.2090</td>\n",
              "      <td>0.2965</td>\n",
              "      <td>-0.0712</td>\n",
              "      <td>0.6389</td>\n",
              "      <td>0.6674</td>\n",
              "      <td>-0.0783</td>\n",
              "      <td>1.1740</td>\n",
              "      <td>-0.7110</td>\n",
              "      <td>...</td>\n",
              "      <td>-0.5943</td>\n",
              "      <td>0.3973</td>\n",
              "      <td>0.1500</td>\n",
              "      <td>0.5178</td>\n",
              "      <td>0.5159</td>\n",
              "      <td>0.6091</td>\n",
              "      <td>0.1813</td>\n",
              "      <td>-0.4249</td>\n",
              "      <td>0.7832</td>\n",
              "      <td>0.6529</td>\n",
              "      <td>0.5648</td>\n",
              "      <td>0.4817</td>\n",
              "      <td>0.0587</td>\n",
              "      <td>0.5303</td>\n",
              "      <td>0.6376</td>\n",
              "      <td>-0.3966</td>\n",
              "      <td>-1.4950</td>\n",
              "      <td>-0.9625</td>\n",
              "      <td>-0.0541</td>\n",
              "      <td>0.6273</td>\n",
              "      <td>0.4563</td>\n",
              "      <td>0.0698</td>\n",
              "      <td>0.8134</td>\n",
              "      <td>0.1924</td>\n",
              "      <td>0.6054</td>\n",
              "      <td>-0.1824</td>\n",
              "      <td>0.0042</td>\n",
              "      <td>0.0048</td>\n",
              "      <td>0.6670</td>\n",
              "      <td>1.0690</td>\n",
              "      <td>0.5523</td>\n",
              "      <td>-0.3031</td>\n",
              "      <td>0.1094</td>\n",
              "      <td>0.2885</td>\n",
              "      <td>-0.3786</td>\n",
              "      <td>0.7125</td>\n",
              "      <td>1</td>\n",
              "      <td>True</td>\n",
              "      <td>0.0</td>\n",
              "      <td>1.0</td>\n",
              "    </tr>\n",
              "  </tbody>\n",
              "</table>\n",
              "<p>5 rows × 880 columns</p>\n",
              "</div>"
            ],
            "text/plain": [
              "             id  tempo  ... tratamento_com_controle tratamento_com_droga\n",
              "0  id_000644bb2     24  ...                     0.0                  1.0\n",
              "1  id_000779bfc     72  ...                     0.0                  1.0\n",
              "2  id_000a6266a     48  ...                     0.0                  1.0\n",
              "3  id_0015fd391     48  ...                     0.0                  1.0\n",
              "4  id_001626bd3     72  ...                     0.0                  1.0\n",
              "\n",
              "[5 rows x 880 columns]"
            ]
          },
          "metadata": {
            "tags": []
          },
          "execution_count": 26
        }
      ]
    },
    {
      "cell_type": "markdown",
      "metadata": {
        "id": "bU2hgEHvMFNs"
      },
      "source": [
        "## Tratamento do Texto Categórico \"tempo\""
      ]
    },
    {
      "cell_type": "code",
      "metadata": {
        "colab": {
          "base_uri": "https://localhost:8080/"
        },
        "id": "qhXq-S8DLTZt",
        "outputId": "64df9b5b-b9f9-4aba-8d1f-f5311dd133b3"
      },
      "source": [
        "dados_combinados['tempo'].unique()"
      ],
      "execution_count": null,
      "outputs": [
        {
          "output_type": "execute_result",
          "data": {
            "text/plain": [
              "array([24, 72, 48])"
            ]
          },
          "metadata": {
            "tags": []
          },
          "execution_count": 27
        }
      ]
    },
    {
      "cell_type": "markdown",
      "metadata": {
        "id": "IqknVmiTMWnp"
      },
      "source": [
        "### Utilizando o \"OneHotEncoder\""
      ]
    },
    {
      "cell_type": "code",
      "metadata": {
        "colab": {
          "base_uri": "https://localhost:8080/"
        },
        "id": "-jlpl_JTMXbh",
        "outputId": "4c4e516a-43ab-42cc-8a2a-97bdb5e25d5b"
      },
      "source": [
        "ohe = preprocessing.OneHotEncoder(handle_unknown='ignore', sparse=False)\n",
        "ohe.fit(dados_combinados[['tempo']])"
      ],
      "execution_count": null,
      "outputs": [
        {
          "output_type": "execute_result",
          "data": {
            "text/plain": [
              "OneHotEncoder(categories='auto', drop=None, dtype=<class 'numpy.float64'>,\n",
              "              handle_unknown='ignore', sparse=False)"
            ]
          },
          "metadata": {
            "tags": []
          },
          "execution_count": 28
        }
      ]
    },
    {
      "cell_type": "code",
      "metadata": {
        "colab": {
          "base_uri": "https://localhost:8080/"
        },
        "id": "djil5vXrNN_7",
        "outputId": "1e78128d-5380-4ef4-dab4-17ba38746cf3"
      },
      "source": [
        "ohe.get_feature_names(['tempo'])"
      ],
      "execution_count": null,
      "outputs": [
        {
          "output_type": "execute_result",
          "data": {
            "text/plain": [
              "array(['tempo_24', 'tempo_48', 'tempo_72'], dtype=object)"
            ]
          },
          "metadata": {
            "tags": []
          },
          "execution_count": 29
        }
      ]
    },
    {
      "cell_type": "code",
      "metadata": {
        "id": "t-Rd-SyWNRj-"
      },
      "source": [
        "# Retorna um Array (Matriz) com uma coluna numérica para cada tempo\n",
        "X = ohe.transform(dados_combinados[['tempo']])"
      ],
      "execution_count": null,
      "outputs": []
    },
    {
      "cell_type": "code",
      "metadata": {
        "colab": {
          "base_uri": "https://localhost:8080/",
          "height": 419
        },
        "id": "9L_gt7JdNdfA",
        "outputId": "b4da1960-79a6-4288-fd8c-acbd237d520b"
      },
      "source": [
        "dados_numericos = pd.DataFrame(X, columns=ohe.get_feature_names(['tempo']))\n",
        "dados_numericos"
      ],
      "execution_count": null,
      "outputs": [
        {
          "output_type": "execute_result",
          "data": {
            "text/html": [
              "<div>\n",
              "<style scoped>\n",
              "    .dataframe tbody tr th:only-of-type {\n",
              "        vertical-align: middle;\n",
              "    }\n",
              "\n",
              "    .dataframe tbody tr th {\n",
              "        vertical-align: top;\n",
              "    }\n",
              "\n",
              "    .dataframe thead th {\n",
              "        text-align: right;\n",
              "    }\n",
              "</style>\n",
              "<table border=\"1\" class=\"dataframe\">\n",
              "  <thead>\n",
              "    <tr style=\"text-align: right;\">\n",
              "      <th></th>\n",
              "      <th>tempo_24</th>\n",
              "      <th>tempo_48</th>\n",
              "      <th>tempo_72</th>\n",
              "    </tr>\n",
              "  </thead>\n",
              "  <tbody>\n",
              "    <tr>\n",
              "      <th>0</th>\n",
              "      <td>1.0</td>\n",
              "      <td>0.0</td>\n",
              "      <td>0.0</td>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>1</th>\n",
              "      <td>0.0</td>\n",
              "      <td>0.0</td>\n",
              "      <td>1.0</td>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>2</th>\n",
              "      <td>0.0</td>\n",
              "      <td>1.0</td>\n",
              "      <td>0.0</td>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>3</th>\n",
              "      <td>0.0</td>\n",
              "      <td>1.0</td>\n",
              "      <td>0.0</td>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>4</th>\n",
              "      <td>0.0</td>\n",
              "      <td>0.0</td>\n",
              "      <td>1.0</td>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>...</th>\n",
              "      <td>...</td>\n",
              "      <td>...</td>\n",
              "      <td>...</td>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>23809</th>\n",
              "      <td>1.0</td>\n",
              "      <td>0.0</td>\n",
              "      <td>0.0</td>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>23810</th>\n",
              "      <td>1.0</td>\n",
              "      <td>0.0</td>\n",
              "      <td>0.0</td>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>23811</th>\n",
              "      <td>0.0</td>\n",
              "      <td>1.0</td>\n",
              "      <td>0.0</td>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>23812</th>\n",
              "      <td>1.0</td>\n",
              "      <td>0.0</td>\n",
              "      <td>0.0</td>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>23813</th>\n",
              "      <td>0.0</td>\n",
              "      <td>0.0</td>\n",
              "      <td>1.0</td>\n",
              "    </tr>\n",
              "  </tbody>\n",
              "</table>\n",
              "<p>23814 rows × 3 columns</p>\n",
              "</div>"
            ],
            "text/plain": [
              "       tempo_24  tempo_48  tempo_72\n",
              "0           1.0       0.0       0.0\n",
              "1           0.0       0.0       1.0\n",
              "2           0.0       1.0       0.0\n",
              "3           0.0       1.0       0.0\n",
              "4           0.0       0.0       1.0\n",
              "...         ...       ...       ...\n",
              "23809       1.0       0.0       0.0\n",
              "23810       1.0       0.0       0.0\n",
              "23811       0.0       1.0       0.0\n",
              "23812       1.0       0.0       0.0\n",
              "23813       0.0       0.0       1.0\n",
              "\n",
              "[23814 rows x 3 columns]"
            ]
          },
          "metadata": {
            "tags": []
          },
          "execution_count": 31
        }
      ]
    },
    {
      "cell_type": "markdown",
      "metadata": {
        "id": "-P9tVtgCNsVP"
      },
      "source": [
        "### Deletando a Coluna Original \"tempo\""
      ]
    },
    {
      "cell_type": "code",
      "metadata": {
        "id": "tHqXH-VTNpQG"
      },
      "source": [
        "dados_combinados = dados_combinados.drop(['tempo'], axis=1)"
      ],
      "execution_count": null,
      "outputs": []
    },
    {
      "cell_type": "markdown",
      "metadata": {
        "id": "4Fttee1gN-2i"
      },
      "source": [
        "### Concatenando os DataFrames"
      ]
    },
    {
      "cell_type": "code",
      "metadata": {
        "colab": {
          "base_uri": "https://localhost:8080/",
          "height": 253
        },
        "id": "YQErgPkmN2IL",
        "outputId": "15d36568-ca43-4779-dd42-bf3824807456"
      },
      "source": [
        "dados_combinados = pd.concat([dados_combinados, dados_numericos], axis=1)\n",
        "dados_combinados.head()"
      ],
      "execution_count": null,
      "outputs": [
        {
          "output_type": "execute_result",
          "data": {
            "text/html": [
              "<div>\n",
              "<style scoped>\n",
              "    .dataframe tbody tr th:only-of-type {\n",
              "        vertical-align: middle;\n",
              "    }\n",
              "\n",
              "    .dataframe tbody tr th {\n",
              "        vertical-align: top;\n",
              "    }\n",
              "\n",
              "    .dataframe thead th {\n",
              "        text-align: right;\n",
              "    }\n",
              "</style>\n",
              "<table border=\"1\" class=\"dataframe\">\n",
              "  <thead>\n",
              "    <tr style=\"text-align: right;\">\n",
              "      <th></th>\n",
              "      <th>id</th>\n",
              "      <th>dose</th>\n",
              "      <th>composto</th>\n",
              "      <th>g0</th>\n",
              "      <th>g1</th>\n",
              "      <th>g2</th>\n",
              "      <th>g3</th>\n",
              "      <th>g4</th>\n",
              "      <th>g5</th>\n",
              "      <th>g6</th>\n",
              "      <th>g7</th>\n",
              "      <th>g8</th>\n",
              "      <th>g9</th>\n",
              "      <th>g10</th>\n",
              "      <th>g11</th>\n",
              "      <th>g12</th>\n",
              "      <th>g13</th>\n",
              "      <th>g14</th>\n",
              "      <th>g15</th>\n",
              "      <th>g16</th>\n",
              "      <th>g17</th>\n",
              "      <th>g18</th>\n",
              "      <th>g19</th>\n",
              "      <th>g20</th>\n",
              "      <th>g21</th>\n",
              "      <th>g22</th>\n",
              "      <th>g23</th>\n",
              "      <th>g24</th>\n",
              "      <th>g25</th>\n",
              "      <th>g26</th>\n",
              "      <th>g27</th>\n",
              "      <th>g28</th>\n",
              "      <th>g29</th>\n",
              "      <th>g30</th>\n",
              "      <th>g31</th>\n",
              "      <th>g32</th>\n",
              "      <th>g33</th>\n",
              "      <th>g34</th>\n",
              "      <th>g35</th>\n",
              "      <th>g36</th>\n",
              "      <th>...</th>\n",
              "      <th>c67</th>\n",
              "      <th>c68</th>\n",
              "      <th>c69</th>\n",
              "      <th>c70</th>\n",
              "      <th>c71</th>\n",
              "      <th>c72</th>\n",
              "      <th>c73</th>\n",
              "      <th>c74</th>\n",
              "      <th>c75</th>\n",
              "      <th>c76</th>\n",
              "      <th>c77</th>\n",
              "      <th>c78</th>\n",
              "      <th>c79</th>\n",
              "      <th>c80</th>\n",
              "      <th>c81</th>\n",
              "      <th>c82</th>\n",
              "      <th>c83</th>\n",
              "      <th>c84</th>\n",
              "      <th>c85</th>\n",
              "      <th>c86</th>\n",
              "      <th>c87</th>\n",
              "      <th>c88</th>\n",
              "      <th>c89</th>\n",
              "      <th>c90</th>\n",
              "      <th>c91</th>\n",
              "      <th>c92</th>\n",
              "      <th>c93</th>\n",
              "      <th>c94</th>\n",
              "      <th>c95</th>\n",
              "      <th>c96</th>\n",
              "      <th>c97</th>\n",
              "      <th>c98</th>\n",
              "      <th>c99</th>\n",
              "      <th>n_moa</th>\n",
              "      <th>ativo_moa</th>\n",
              "      <th>tratamento_com_controle</th>\n",
              "      <th>tratamento_com_droga</th>\n",
              "      <th>tempo_24</th>\n",
              "      <th>tempo_48</th>\n",
              "      <th>tempo_72</th>\n",
              "    </tr>\n",
              "  </thead>\n",
              "  <tbody>\n",
              "    <tr>\n",
              "      <th>0</th>\n",
              "      <td>id_000644bb2</td>\n",
              "      <td>D1</td>\n",
              "      <td>b68db1d53</td>\n",
              "      <td>1.0620</td>\n",
              "      <td>0.5577</td>\n",
              "      <td>-0.2479</td>\n",
              "      <td>-0.6208</td>\n",
              "      <td>-0.1944</td>\n",
              "      <td>-1.0120</td>\n",
              "      <td>-1.0220</td>\n",
              "      <td>-0.0326</td>\n",
              "      <td>0.5548</td>\n",
              "      <td>-0.0921</td>\n",
              "      <td>1.1830</td>\n",
              "      <td>0.1530</td>\n",
              "      <td>0.5574</td>\n",
              "      <td>-0.4015</td>\n",
              "      <td>0.1789</td>\n",
              "      <td>-0.6528</td>\n",
              "      <td>-0.7969</td>\n",
              "      <td>0.6342</td>\n",
              "      <td>0.1778</td>\n",
              "      <td>-0.3694</td>\n",
              "      <td>-0.5688</td>\n",
              "      <td>-1.1360</td>\n",
              "      <td>-1.1880</td>\n",
              "      <td>0.6940</td>\n",
              "      <td>0.4393</td>\n",
              "      <td>0.2664</td>\n",
              "      <td>0.1907</td>\n",
              "      <td>0.1628</td>\n",
              "      <td>-0.2853</td>\n",
              "      <td>0.5819</td>\n",
              "      <td>0.2934</td>\n",
              "      <td>-0.5584</td>\n",
              "      <td>-0.0916</td>\n",
              "      <td>-0.3010</td>\n",
              "      <td>-0.1537</td>\n",
              "      <td>0.2198</td>\n",
              "      <td>0.2965</td>\n",
              "      <td>...</td>\n",
              "      <td>1.2570</td>\n",
              "      <td>-0.5979</td>\n",
              "      <td>1.2250</td>\n",
              "      <td>-0.0553</td>\n",
              "      <td>0.7351</td>\n",
              "      <td>0.5810</td>\n",
              "      <td>0.9590</td>\n",
              "      <td>0.2427</td>\n",
              "      <td>0.0495</td>\n",
              "      <td>0.4141</td>\n",
              "      <td>0.8432</td>\n",
              "      <td>0.6162</td>\n",
              "      <td>-0.7318</td>\n",
              "      <td>1.2120</td>\n",
              "      <td>0.6362</td>\n",
              "      <td>-0.4427</td>\n",
              "      <td>0.1288</td>\n",
              "      <td>1.4840</td>\n",
              "      <td>0.1799</td>\n",
              "      <td>0.5367</td>\n",
              "      <td>-0.1111</td>\n",
              "      <td>-1.0120</td>\n",
              "      <td>0.6685</td>\n",
              "      <td>0.2862</td>\n",
              "      <td>0.2584</td>\n",
              "      <td>0.8076</td>\n",
              "      <td>0.5523</td>\n",
              "      <td>-0.1912</td>\n",
              "      <td>0.6584</td>\n",
              "      <td>-0.3981</td>\n",
              "      <td>0.2139</td>\n",
              "      <td>0.3801</td>\n",
              "      <td>0.4176</td>\n",
              "      <td>1</td>\n",
              "      <td>True</td>\n",
              "      <td>0.0</td>\n",
              "      <td>1.0</td>\n",
              "      <td>1.0</td>\n",
              "      <td>0.0</td>\n",
              "      <td>0.0</td>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>1</th>\n",
              "      <td>id_000779bfc</td>\n",
              "      <td>D1</td>\n",
              "      <td>df89a8e5a</td>\n",
              "      <td>0.0743</td>\n",
              "      <td>0.4087</td>\n",
              "      <td>0.2991</td>\n",
              "      <td>0.0604</td>\n",
              "      <td>1.0190</td>\n",
              "      <td>0.5207</td>\n",
              "      <td>0.2341</td>\n",
              "      <td>0.3372</td>\n",
              "      <td>-0.4047</td>\n",
              "      <td>0.8507</td>\n",
              "      <td>-1.1520</td>\n",
              "      <td>-0.4201</td>\n",
              "      <td>-0.0958</td>\n",
              "      <td>0.4590</td>\n",
              "      <td>0.0803</td>\n",
              "      <td>0.2250</td>\n",
              "      <td>0.5293</td>\n",
              "      <td>0.2839</td>\n",
              "      <td>-0.3494</td>\n",
              "      <td>0.2883</td>\n",
              "      <td>0.9449</td>\n",
              "      <td>-0.1646</td>\n",
              "      <td>-0.2657</td>\n",
              "      <td>-0.3372</td>\n",
              "      <td>0.3135</td>\n",
              "      <td>-0.4316</td>\n",
              "      <td>0.4773</td>\n",
              "      <td>0.2075</td>\n",
              "      <td>-0.4216</td>\n",
              "      <td>-0.1161</td>\n",
              "      <td>-0.0499</td>\n",
              "      <td>-0.2627</td>\n",
              "      <td>0.9959</td>\n",
              "      <td>-0.2483</td>\n",
              "      <td>0.2655</td>\n",
              "      <td>-0.2102</td>\n",
              "      <td>0.1656</td>\n",
              "      <td>...</td>\n",
              "      <td>-0.3104</td>\n",
              "      <td>-0.6373</td>\n",
              "      <td>0.2887</td>\n",
              "      <td>-0.0765</td>\n",
              "      <td>0.2539</td>\n",
              "      <td>0.4443</td>\n",
              "      <td>0.5932</td>\n",
              "      <td>0.2031</td>\n",
              "      <td>0.7639</td>\n",
              "      <td>0.5499</td>\n",
              "      <td>-0.3322</td>\n",
              "      <td>-0.0977</td>\n",
              "      <td>0.4329</td>\n",
              "      <td>-0.2782</td>\n",
              "      <td>0.7827</td>\n",
              "      <td>0.5934</td>\n",
              "      <td>0.3402</td>\n",
              "      <td>0.1499</td>\n",
              "      <td>0.4420</td>\n",
              "      <td>0.9366</td>\n",
              "      <td>0.8193</td>\n",
              "      <td>-0.4236</td>\n",
              "      <td>0.3192</td>\n",
              "      <td>-0.4265</td>\n",
              "      <td>0.7543</td>\n",
              "      <td>0.4708</td>\n",
              "      <td>0.0230</td>\n",
              "      <td>0.2957</td>\n",
              "      <td>0.4899</td>\n",
              "      <td>0.1522</td>\n",
              "      <td>0.1241</td>\n",
              "      <td>0.6077</td>\n",
              "      <td>0.7371</td>\n",
              "      <td>0</td>\n",
              "      <td>False</td>\n",
              "      <td>0.0</td>\n",
              "      <td>1.0</td>\n",
              "      <td>0.0</td>\n",
              "      <td>0.0</td>\n",
              "      <td>1.0</td>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>2</th>\n",
              "      <td>id_000a6266a</td>\n",
              "      <td>D1</td>\n",
              "      <td>18bb41b2c</td>\n",
              "      <td>0.6280</td>\n",
              "      <td>0.5817</td>\n",
              "      <td>1.5540</td>\n",
              "      <td>-0.0764</td>\n",
              "      <td>-0.0323</td>\n",
              "      <td>1.2390</td>\n",
              "      <td>0.1715</td>\n",
              "      <td>0.2155</td>\n",
              "      <td>0.0065</td>\n",
              "      <td>1.2300</td>\n",
              "      <td>-0.4797</td>\n",
              "      <td>-0.5631</td>\n",
              "      <td>-0.0366</td>\n",
              "      <td>-1.8300</td>\n",
              "      <td>0.6057</td>\n",
              "      <td>-0.3278</td>\n",
              "      <td>0.6042</td>\n",
              "      <td>-0.3075</td>\n",
              "      <td>-0.1147</td>\n",
              "      <td>-0.0570</td>\n",
              "      <td>-0.0799</td>\n",
              "      <td>-0.8181</td>\n",
              "      <td>-1.5320</td>\n",
              "      <td>0.2307</td>\n",
              "      <td>0.4901</td>\n",
              "      <td>0.4780</td>\n",
              "      <td>-1.3970</td>\n",
              "      <td>4.6240</td>\n",
              "      <td>-0.0437</td>\n",
              "      <td>1.2870</td>\n",
              "      <td>-1.8530</td>\n",
              "      <td>0.6069</td>\n",
              "      <td>0.4290</td>\n",
              "      <td>0.1783</td>\n",
              "      <td>0.0018</td>\n",
              "      <td>-1.1800</td>\n",
              "      <td>0.1256</td>\n",
              "      <td>...</td>\n",
              "      <td>0.1210</td>\n",
              "      <td>-0.5177</td>\n",
              "      <td>-0.0604</td>\n",
              "      <td>0.1682</td>\n",
              "      <td>-0.4436</td>\n",
              "      <td>0.4963</td>\n",
              "      <td>0.1363</td>\n",
              "      <td>0.3335</td>\n",
              "      <td>0.9760</td>\n",
              "      <td>-0.0427</td>\n",
              "      <td>-0.1235</td>\n",
              "      <td>0.0959</td>\n",
              "      <td>0.0690</td>\n",
              "      <td>-0.9416</td>\n",
              "      <td>-0.7548</td>\n",
              "      <td>-0.1109</td>\n",
              "      <td>-0.6272</td>\n",
              "      <td>0.3019</td>\n",
              "      <td>0.1172</td>\n",
              "      <td>0.1093</td>\n",
              "      <td>-0.3113</td>\n",
              "      <td>0.3019</td>\n",
              "      <td>-0.0873</td>\n",
              "      <td>-0.7250</td>\n",
              "      <td>-0.6297</td>\n",
              "      <td>0.6103</td>\n",
              "      <td>0.0223</td>\n",
              "      <td>-1.3240</td>\n",
              "      <td>-0.3174</td>\n",
              "      <td>-0.6417</td>\n",
              "      <td>-0.2187</td>\n",
              "      <td>-1.4080</td>\n",
              "      <td>0.6931</td>\n",
              "      <td>3</td>\n",
              "      <td>True</td>\n",
              "      <td>0.0</td>\n",
              "      <td>1.0</td>\n",
              "      <td>0.0</td>\n",
              "      <td>1.0</td>\n",
              "      <td>0.0</td>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>3</th>\n",
              "      <td>id_0015fd391</td>\n",
              "      <td>D1</td>\n",
              "      <td>8c7f86626</td>\n",
              "      <td>-0.5138</td>\n",
              "      <td>-0.2491</td>\n",
              "      <td>-0.2656</td>\n",
              "      <td>0.5288</td>\n",
              "      <td>4.0620</td>\n",
              "      <td>-0.8095</td>\n",
              "      <td>-1.9590</td>\n",
              "      <td>0.1792</td>\n",
              "      <td>-0.1321</td>\n",
              "      <td>-1.0600</td>\n",
              "      <td>-0.8269</td>\n",
              "      <td>-0.3584</td>\n",
              "      <td>-0.8511</td>\n",
              "      <td>-0.5844</td>\n",
              "      <td>-2.5690</td>\n",
              "      <td>0.8183</td>\n",
              "      <td>-0.0532</td>\n",
              "      <td>-0.8554</td>\n",
              "      <td>0.1160</td>\n",
              "      <td>-2.3520</td>\n",
              "      <td>2.1200</td>\n",
              "      <td>-1.1580</td>\n",
              "      <td>-0.7191</td>\n",
              "      <td>-0.8004</td>\n",
              "      <td>-1.4670</td>\n",
              "      <td>-0.0107</td>\n",
              "      <td>-0.8995</td>\n",
              "      <td>0.2406</td>\n",
              "      <td>-0.2479</td>\n",
              "      <td>-1.0890</td>\n",
              "      <td>-0.7575</td>\n",
              "      <td>0.0881</td>\n",
              "      <td>-2.7370</td>\n",
              "      <td>0.8745</td>\n",
              "      <td>0.5787</td>\n",
              "      <td>-1.6740</td>\n",
              "      <td>-1.6720</td>\n",
              "      <td>...</td>\n",
              "      <td>-3.1660</td>\n",
              "      <td>0.2816</td>\n",
              "      <td>-0.2990</td>\n",
              "      <td>-1.1870</td>\n",
              "      <td>-0.5044</td>\n",
              "      <td>-1.7750</td>\n",
              "      <td>-1.6120</td>\n",
              "      <td>-0.9215</td>\n",
              "      <td>-1.0810</td>\n",
              "      <td>-3.0520</td>\n",
              "      <td>-3.4470</td>\n",
              "      <td>-2.7740</td>\n",
              "      <td>-1.8460</td>\n",
              "      <td>-0.5568</td>\n",
              "      <td>-3.3960</td>\n",
              "      <td>-2.9510</td>\n",
              "      <td>-1.1550</td>\n",
              "      <td>-3.2620</td>\n",
              "      <td>-1.5390</td>\n",
              "      <td>-2.4600</td>\n",
              "      <td>-0.9417</td>\n",
              "      <td>-1.5550</td>\n",
              "      <td>0.2431</td>\n",
              "      <td>-2.0990</td>\n",
              "      <td>-0.6441</td>\n",
              "      <td>-5.6300</td>\n",
              "      <td>-1.3780</td>\n",
              "      <td>-0.8632</td>\n",
              "      <td>-1.2880</td>\n",
              "      <td>-1.6210</td>\n",
              "      <td>-0.8784</td>\n",
              "      <td>-0.3876</td>\n",
              "      <td>-0.8154</td>\n",
              "      <td>0</td>\n",
              "      <td>False</td>\n",
              "      <td>0.0</td>\n",
              "      <td>1.0</td>\n",
              "      <td>0.0</td>\n",
              "      <td>1.0</td>\n",
              "      <td>0.0</td>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>4</th>\n",
              "      <td>id_001626bd3</td>\n",
              "      <td>D2</td>\n",
              "      <td>7cbed3131</td>\n",
              "      <td>-0.3254</td>\n",
              "      <td>-0.4009</td>\n",
              "      <td>0.9700</td>\n",
              "      <td>0.6919</td>\n",
              "      <td>1.4180</td>\n",
              "      <td>-0.8244</td>\n",
              "      <td>-0.2800</td>\n",
              "      <td>-0.1498</td>\n",
              "      <td>-0.8789</td>\n",
              "      <td>0.8630</td>\n",
              "      <td>-0.2219</td>\n",
              "      <td>-0.5121</td>\n",
              "      <td>-0.9577</td>\n",
              "      <td>1.1750</td>\n",
              "      <td>0.2042</td>\n",
              "      <td>0.1970</td>\n",
              "      <td>0.1244</td>\n",
              "      <td>-1.7090</td>\n",
              "      <td>-0.3543</td>\n",
              "      <td>-0.5160</td>\n",
              "      <td>-0.3330</td>\n",
              "      <td>-0.2685</td>\n",
              "      <td>0.7649</td>\n",
              "      <td>0.2057</td>\n",
              "      <td>1.3720</td>\n",
              "      <td>0.6835</td>\n",
              "      <td>0.8056</td>\n",
              "      <td>-0.3754</td>\n",
              "      <td>-1.2090</td>\n",
              "      <td>0.2965</td>\n",
              "      <td>-0.0712</td>\n",
              "      <td>0.6389</td>\n",
              "      <td>0.6674</td>\n",
              "      <td>-0.0783</td>\n",
              "      <td>1.1740</td>\n",
              "      <td>-0.7110</td>\n",
              "      <td>-1.4470</td>\n",
              "      <td>...</td>\n",
              "      <td>0.5178</td>\n",
              "      <td>0.5159</td>\n",
              "      <td>0.6091</td>\n",
              "      <td>0.1813</td>\n",
              "      <td>-0.4249</td>\n",
              "      <td>0.7832</td>\n",
              "      <td>0.6529</td>\n",
              "      <td>0.5648</td>\n",
              "      <td>0.4817</td>\n",
              "      <td>0.0587</td>\n",
              "      <td>0.5303</td>\n",
              "      <td>0.6376</td>\n",
              "      <td>-0.3966</td>\n",
              "      <td>-1.4950</td>\n",
              "      <td>-0.9625</td>\n",
              "      <td>-0.0541</td>\n",
              "      <td>0.6273</td>\n",
              "      <td>0.4563</td>\n",
              "      <td>0.0698</td>\n",
              "      <td>0.8134</td>\n",
              "      <td>0.1924</td>\n",
              "      <td>0.6054</td>\n",
              "      <td>-0.1824</td>\n",
              "      <td>0.0042</td>\n",
              "      <td>0.0048</td>\n",
              "      <td>0.6670</td>\n",
              "      <td>1.0690</td>\n",
              "      <td>0.5523</td>\n",
              "      <td>-0.3031</td>\n",
              "      <td>0.1094</td>\n",
              "      <td>0.2885</td>\n",
              "      <td>-0.3786</td>\n",
              "      <td>0.7125</td>\n",
              "      <td>1</td>\n",
              "      <td>True</td>\n",
              "      <td>0.0</td>\n",
              "      <td>1.0</td>\n",
              "      <td>0.0</td>\n",
              "      <td>0.0</td>\n",
              "      <td>1.0</td>\n",
              "    </tr>\n",
              "  </tbody>\n",
              "</table>\n",
              "<p>5 rows × 882 columns</p>\n",
              "</div>"
            ],
            "text/plain": [
              "             id dose   composto  ...  tempo_24  tempo_48  tempo_72\n",
              "0  id_000644bb2   D1  b68db1d53  ...       1.0       0.0       0.0\n",
              "1  id_000779bfc   D1  df89a8e5a  ...       0.0       0.0       1.0\n",
              "2  id_000a6266a   D1  18bb41b2c  ...       0.0       1.0       0.0\n",
              "3  id_0015fd391   D1  8c7f86626  ...       0.0       1.0       0.0\n",
              "4  id_001626bd3   D2  7cbed3131  ...       0.0       0.0       1.0\n",
              "\n",
              "[5 rows x 882 columns]"
            ]
          },
          "metadata": {
            "tags": []
          },
          "execution_count": 33
        }
      ]
    },
    {
      "cell_type": "markdown",
      "metadata": {
        "id": "0_hkeHitOcXf"
      },
      "source": [
        "## Tratamento do Texto Categórico \"dose\""
      ]
    },
    {
      "cell_type": "code",
      "metadata": {
        "colab": {
          "base_uri": "https://localhost:8080/"
        },
        "id": "_fiJiXPLOIzR",
        "outputId": "068d9f2b-f5a0-443f-e611-abafba9aeb77"
      },
      "source": [
        "dados_combinados['dose'].unique()"
      ],
      "execution_count": null,
      "outputs": [
        {
          "output_type": "execute_result",
          "data": {
            "text/plain": [
              "array(['D1', 'D2'], dtype=object)"
            ]
          },
          "metadata": {
            "tags": []
          },
          "execution_count": 34
        }
      ]
    },
    {
      "cell_type": "code",
      "metadata": {
        "colab": {
          "base_uri": "https://localhost:8080/"
        },
        "id": "SSfaVw0tOflI",
        "outputId": "5ceb8347-ce5f-4b74-c15f-b69ce552ccfa"
      },
      "source": [
        "ohe = preprocessing.OneHotEncoder(handle_unknown='ignore', sparse=False)\n",
        "ohe.fit(dados_combinados[['dose']])"
      ],
      "execution_count": null,
      "outputs": [
        {
          "output_type": "execute_result",
          "data": {
            "text/plain": [
              "OneHotEncoder(categories='auto', drop=None, dtype=<class 'numpy.float64'>,\n",
              "              handle_unknown='ignore', sparse=False)"
            ]
          },
          "metadata": {
            "tags": []
          },
          "execution_count": 35
        }
      ]
    },
    {
      "cell_type": "code",
      "metadata": {
        "colab": {
          "base_uri": "https://localhost:8080/"
        },
        "id": "LL8ommtZO4BS",
        "outputId": "6c4037ae-7240-414a-8e08-5c0e9232ce8f"
      },
      "source": [
        "ohe.get_feature_names(['dose'])"
      ],
      "execution_count": null,
      "outputs": [
        {
          "output_type": "execute_result",
          "data": {
            "text/plain": [
              "array(['dose_D1', 'dose_D2'], dtype=object)"
            ]
          },
          "metadata": {
            "tags": []
          },
          "execution_count": 36
        }
      ]
    },
    {
      "cell_type": "code",
      "metadata": {
        "colab": {
          "base_uri": "https://localhost:8080/",
          "height": 204
        },
        "id": "PXDkZioWPAzA",
        "outputId": "0fb3eac0-55f3-400c-b9de-3a04701dd450"
      },
      "source": [
        "# Retorna um Array (Matriz) com uma coluna numérica para cada dose\n",
        "X = ohe.transform(dados_combinados[['dose']])\n",
        "\n",
        "dados_numericos = pd.DataFrame(X, columns=ohe.get_feature_names(['dose']))\n",
        "dados_numericos.head()"
      ],
      "execution_count": null,
      "outputs": [
        {
          "output_type": "execute_result",
          "data": {
            "text/html": [
              "<div>\n",
              "<style scoped>\n",
              "    .dataframe tbody tr th:only-of-type {\n",
              "        vertical-align: middle;\n",
              "    }\n",
              "\n",
              "    .dataframe tbody tr th {\n",
              "        vertical-align: top;\n",
              "    }\n",
              "\n",
              "    .dataframe thead th {\n",
              "        text-align: right;\n",
              "    }\n",
              "</style>\n",
              "<table border=\"1\" class=\"dataframe\">\n",
              "  <thead>\n",
              "    <tr style=\"text-align: right;\">\n",
              "      <th></th>\n",
              "      <th>dose_D1</th>\n",
              "      <th>dose_D2</th>\n",
              "    </tr>\n",
              "  </thead>\n",
              "  <tbody>\n",
              "    <tr>\n",
              "      <th>0</th>\n",
              "      <td>1.0</td>\n",
              "      <td>0.0</td>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>1</th>\n",
              "      <td>1.0</td>\n",
              "      <td>0.0</td>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>2</th>\n",
              "      <td>1.0</td>\n",
              "      <td>0.0</td>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>3</th>\n",
              "      <td>1.0</td>\n",
              "      <td>0.0</td>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>4</th>\n",
              "      <td>0.0</td>\n",
              "      <td>1.0</td>\n",
              "    </tr>\n",
              "  </tbody>\n",
              "</table>\n",
              "</div>"
            ],
            "text/plain": [
              "   dose_D1  dose_D2\n",
              "0      1.0      0.0\n",
              "1      1.0      0.0\n",
              "2      1.0      0.0\n",
              "3      1.0      0.0\n",
              "4      0.0      1.0"
            ]
          },
          "metadata": {
            "tags": []
          },
          "execution_count": 37
        }
      ]
    },
    {
      "cell_type": "markdown",
      "metadata": {
        "id": "F7jNbR_-PcsE"
      },
      "source": [
        "### Deletando a Coluna Original \"dose\""
      ]
    },
    {
      "cell_type": "code",
      "metadata": {
        "id": "NtKQUjhvPYry"
      },
      "source": [
        "dados_combinados = dados_combinados.drop(['dose'], axis=1)"
      ],
      "execution_count": null,
      "outputs": []
    },
    {
      "cell_type": "markdown",
      "metadata": {
        "id": "aUh06-_kPmwg"
      },
      "source": [
        "### Concatenando os DataFrames"
      ]
    },
    {
      "cell_type": "code",
      "metadata": {
        "colab": {
          "base_uri": "https://localhost:8080/",
          "height": 253
        },
        "id": "u_2iGkkzPlop",
        "outputId": "1a49ffca-aea5-4312-c3bd-252bdef90c14"
      },
      "source": [
        "dados_combinados = pd.concat([dados_combinados, dados_numericos], axis=1)\n",
        "dados_combinados.head()"
      ],
      "execution_count": null,
      "outputs": [
        {
          "output_type": "execute_result",
          "data": {
            "text/html": [
              "<div>\n",
              "<style scoped>\n",
              "    .dataframe tbody tr th:only-of-type {\n",
              "        vertical-align: middle;\n",
              "    }\n",
              "\n",
              "    .dataframe tbody tr th {\n",
              "        vertical-align: top;\n",
              "    }\n",
              "\n",
              "    .dataframe thead th {\n",
              "        text-align: right;\n",
              "    }\n",
              "</style>\n",
              "<table border=\"1\" class=\"dataframe\">\n",
              "  <thead>\n",
              "    <tr style=\"text-align: right;\">\n",
              "      <th></th>\n",
              "      <th>id</th>\n",
              "      <th>composto</th>\n",
              "      <th>g0</th>\n",
              "      <th>g1</th>\n",
              "      <th>g2</th>\n",
              "      <th>g3</th>\n",
              "      <th>g4</th>\n",
              "      <th>g5</th>\n",
              "      <th>g6</th>\n",
              "      <th>g7</th>\n",
              "      <th>g8</th>\n",
              "      <th>g9</th>\n",
              "      <th>g10</th>\n",
              "      <th>g11</th>\n",
              "      <th>g12</th>\n",
              "      <th>g13</th>\n",
              "      <th>g14</th>\n",
              "      <th>g15</th>\n",
              "      <th>g16</th>\n",
              "      <th>g17</th>\n",
              "      <th>g18</th>\n",
              "      <th>g19</th>\n",
              "      <th>g20</th>\n",
              "      <th>g21</th>\n",
              "      <th>g22</th>\n",
              "      <th>g23</th>\n",
              "      <th>g24</th>\n",
              "      <th>g25</th>\n",
              "      <th>g26</th>\n",
              "      <th>g27</th>\n",
              "      <th>g28</th>\n",
              "      <th>g29</th>\n",
              "      <th>g30</th>\n",
              "      <th>g31</th>\n",
              "      <th>g32</th>\n",
              "      <th>g33</th>\n",
              "      <th>g34</th>\n",
              "      <th>g35</th>\n",
              "      <th>g36</th>\n",
              "      <th>g37</th>\n",
              "      <th>...</th>\n",
              "      <th>c69</th>\n",
              "      <th>c70</th>\n",
              "      <th>c71</th>\n",
              "      <th>c72</th>\n",
              "      <th>c73</th>\n",
              "      <th>c74</th>\n",
              "      <th>c75</th>\n",
              "      <th>c76</th>\n",
              "      <th>c77</th>\n",
              "      <th>c78</th>\n",
              "      <th>c79</th>\n",
              "      <th>c80</th>\n",
              "      <th>c81</th>\n",
              "      <th>c82</th>\n",
              "      <th>c83</th>\n",
              "      <th>c84</th>\n",
              "      <th>c85</th>\n",
              "      <th>c86</th>\n",
              "      <th>c87</th>\n",
              "      <th>c88</th>\n",
              "      <th>c89</th>\n",
              "      <th>c90</th>\n",
              "      <th>c91</th>\n",
              "      <th>c92</th>\n",
              "      <th>c93</th>\n",
              "      <th>c94</th>\n",
              "      <th>c95</th>\n",
              "      <th>c96</th>\n",
              "      <th>c97</th>\n",
              "      <th>c98</th>\n",
              "      <th>c99</th>\n",
              "      <th>n_moa</th>\n",
              "      <th>ativo_moa</th>\n",
              "      <th>tratamento_com_controle</th>\n",
              "      <th>tratamento_com_droga</th>\n",
              "      <th>tempo_24</th>\n",
              "      <th>tempo_48</th>\n",
              "      <th>tempo_72</th>\n",
              "      <th>dose_D1</th>\n",
              "      <th>dose_D2</th>\n",
              "    </tr>\n",
              "  </thead>\n",
              "  <tbody>\n",
              "    <tr>\n",
              "      <th>0</th>\n",
              "      <td>id_000644bb2</td>\n",
              "      <td>b68db1d53</td>\n",
              "      <td>1.0620</td>\n",
              "      <td>0.5577</td>\n",
              "      <td>-0.2479</td>\n",
              "      <td>-0.6208</td>\n",
              "      <td>-0.1944</td>\n",
              "      <td>-1.0120</td>\n",
              "      <td>-1.0220</td>\n",
              "      <td>-0.0326</td>\n",
              "      <td>0.5548</td>\n",
              "      <td>-0.0921</td>\n",
              "      <td>1.1830</td>\n",
              "      <td>0.1530</td>\n",
              "      <td>0.5574</td>\n",
              "      <td>-0.4015</td>\n",
              "      <td>0.1789</td>\n",
              "      <td>-0.6528</td>\n",
              "      <td>-0.7969</td>\n",
              "      <td>0.6342</td>\n",
              "      <td>0.1778</td>\n",
              "      <td>-0.3694</td>\n",
              "      <td>-0.5688</td>\n",
              "      <td>-1.1360</td>\n",
              "      <td>-1.1880</td>\n",
              "      <td>0.6940</td>\n",
              "      <td>0.4393</td>\n",
              "      <td>0.2664</td>\n",
              "      <td>0.1907</td>\n",
              "      <td>0.1628</td>\n",
              "      <td>-0.2853</td>\n",
              "      <td>0.5819</td>\n",
              "      <td>0.2934</td>\n",
              "      <td>-0.5584</td>\n",
              "      <td>-0.0916</td>\n",
              "      <td>-0.3010</td>\n",
              "      <td>-0.1537</td>\n",
              "      <td>0.2198</td>\n",
              "      <td>0.2965</td>\n",
              "      <td>-0.5055</td>\n",
              "      <td>...</td>\n",
              "      <td>1.2250</td>\n",
              "      <td>-0.0553</td>\n",
              "      <td>0.7351</td>\n",
              "      <td>0.5810</td>\n",
              "      <td>0.9590</td>\n",
              "      <td>0.2427</td>\n",
              "      <td>0.0495</td>\n",
              "      <td>0.4141</td>\n",
              "      <td>0.8432</td>\n",
              "      <td>0.6162</td>\n",
              "      <td>-0.7318</td>\n",
              "      <td>1.2120</td>\n",
              "      <td>0.6362</td>\n",
              "      <td>-0.4427</td>\n",
              "      <td>0.1288</td>\n",
              "      <td>1.4840</td>\n",
              "      <td>0.1799</td>\n",
              "      <td>0.5367</td>\n",
              "      <td>-0.1111</td>\n",
              "      <td>-1.0120</td>\n",
              "      <td>0.6685</td>\n",
              "      <td>0.2862</td>\n",
              "      <td>0.2584</td>\n",
              "      <td>0.8076</td>\n",
              "      <td>0.5523</td>\n",
              "      <td>-0.1912</td>\n",
              "      <td>0.6584</td>\n",
              "      <td>-0.3981</td>\n",
              "      <td>0.2139</td>\n",
              "      <td>0.3801</td>\n",
              "      <td>0.4176</td>\n",
              "      <td>1</td>\n",
              "      <td>True</td>\n",
              "      <td>0.0</td>\n",
              "      <td>1.0</td>\n",
              "      <td>1.0</td>\n",
              "      <td>0.0</td>\n",
              "      <td>0.0</td>\n",
              "      <td>1.0</td>\n",
              "      <td>0.0</td>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>1</th>\n",
              "      <td>id_000779bfc</td>\n",
              "      <td>df89a8e5a</td>\n",
              "      <td>0.0743</td>\n",
              "      <td>0.4087</td>\n",
              "      <td>0.2991</td>\n",
              "      <td>0.0604</td>\n",
              "      <td>1.0190</td>\n",
              "      <td>0.5207</td>\n",
              "      <td>0.2341</td>\n",
              "      <td>0.3372</td>\n",
              "      <td>-0.4047</td>\n",
              "      <td>0.8507</td>\n",
              "      <td>-1.1520</td>\n",
              "      <td>-0.4201</td>\n",
              "      <td>-0.0958</td>\n",
              "      <td>0.4590</td>\n",
              "      <td>0.0803</td>\n",
              "      <td>0.2250</td>\n",
              "      <td>0.5293</td>\n",
              "      <td>0.2839</td>\n",
              "      <td>-0.3494</td>\n",
              "      <td>0.2883</td>\n",
              "      <td>0.9449</td>\n",
              "      <td>-0.1646</td>\n",
              "      <td>-0.2657</td>\n",
              "      <td>-0.3372</td>\n",
              "      <td>0.3135</td>\n",
              "      <td>-0.4316</td>\n",
              "      <td>0.4773</td>\n",
              "      <td>0.2075</td>\n",
              "      <td>-0.4216</td>\n",
              "      <td>-0.1161</td>\n",
              "      <td>-0.0499</td>\n",
              "      <td>-0.2627</td>\n",
              "      <td>0.9959</td>\n",
              "      <td>-0.2483</td>\n",
              "      <td>0.2655</td>\n",
              "      <td>-0.2102</td>\n",
              "      <td>0.1656</td>\n",
              "      <td>0.5300</td>\n",
              "      <td>...</td>\n",
              "      <td>0.2887</td>\n",
              "      <td>-0.0765</td>\n",
              "      <td>0.2539</td>\n",
              "      <td>0.4443</td>\n",
              "      <td>0.5932</td>\n",
              "      <td>0.2031</td>\n",
              "      <td>0.7639</td>\n",
              "      <td>0.5499</td>\n",
              "      <td>-0.3322</td>\n",
              "      <td>-0.0977</td>\n",
              "      <td>0.4329</td>\n",
              "      <td>-0.2782</td>\n",
              "      <td>0.7827</td>\n",
              "      <td>0.5934</td>\n",
              "      <td>0.3402</td>\n",
              "      <td>0.1499</td>\n",
              "      <td>0.4420</td>\n",
              "      <td>0.9366</td>\n",
              "      <td>0.8193</td>\n",
              "      <td>-0.4236</td>\n",
              "      <td>0.3192</td>\n",
              "      <td>-0.4265</td>\n",
              "      <td>0.7543</td>\n",
              "      <td>0.4708</td>\n",
              "      <td>0.0230</td>\n",
              "      <td>0.2957</td>\n",
              "      <td>0.4899</td>\n",
              "      <td>0.1522</td>\n",
              "      <td>0.1241</td>\n",
              "      <td>0.6077</td>\n",
              "      <td>0.7371</td>\n",
              "      <td>0</td>\n",
              "      <td>False</td>\n",
              "      <td>0.0</td>\n",
              "      <td>1.0</td>\n",
              "      <td>0.0</td>\n",
              "      <td>0.0</td>\n",
              "      <td>1.0</td>\n",
              "      <td>1.0</td>\n",
              "      <td>0.0</td>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>2</th>\n",
              "      <td>id_000a6266a</td>\n",
              "      <td>18bb41b2c</td>\n",
              "      <td>0.6280</td>\n",
              "      <td>0.5817</td>\n",
              "      <td>1.5540</td>\n",
              "      <td>-0.0764</td>\n",
              "      <td>-0.0323</td>\n",
              "      <td>1.2390</td>\n",
              "      <td>0.1715</td>\n",
              "      <td>0.2155</td>\n",
              "      <td>0.0065</td>\n",
              "      <td>1.2300</td>\n",
              "      <td>-0.4797</td>\n",
              "      <td>-0.5631</td>\n",
              "      <td>-0.0366</td>\n",
              "      <td>-1.8300</td>\n",
              "      <td>0.6057</td>\n",
              "      <td>-0.3278</td>\n",
              "      <td>0.6042</td>\n",
              "      <td>-0.3075</td>\n",
              "      <td>-0.1147</td>\n",
              "      <td>-0.0570</td>\n",
              "      <td>-0.0799</td>\n",
              "      <td>-0.8181</td>\n",
              "      <td>-1.5320</td>\n",
              "      <td>0.2307</td>\n",
              "      <td>0.4901</td>\n",
              "      <td>0.4780</td>\n",
              "      <td>-1.3970</td>\n",
              "      <td>4.6240</td>\n",
              "      <td>-0.0437</td>\n",
              "      <td>1.2870</td>\n",
              "      <td>-1.8530</td>\n",
              "      <td>0.6069</td>\n",
              "      <td>0.4290</td>\n",
              "      <td>0.1783</td>\n",
              "      <td>0.0018</td>\n",
              "      <td>-1.1800</td>\n",
              "      <td>0.1256</td>\n",
              "      <td>-0.1219</td>\n",
              "      <td>...</td>\n",
              "      <td>-0.0604</td>\n",
              "      <td>0.1682</td>\n",
              "      <td>-0.4436</td>\n",
              "      <td>0.4963</td>\n",
              "      <td>0.1363</td>\n",
              "      <td>0.3335</td>\n",
              "      <td>0.9760</td>\n",
              "      <td>-0.0427</td>\n",
              "      <td>-0.1235</td>\n",
              "      <td>0.0959</td>\n",
              "      <td>0.0690</td>\n",
              "      <td>-0.9416</td>\n",
              "      <td>-0.7548</td>\n",
              "      <td>-0.1109</td>\n",
              "      <td>-0.6272</td>\n",
              "      <td>0.3019</td>\n",
              "      <td>0.1172</td>\n",
              "      <td>0.1093</td>\n",
              "      <td>-0.3113</td>\n",
              "      <td>0.3019</td>\n",
              "      <td>-0.0873</td>\n",
              "      <td>-0.7250</td>\n",
              "      <td>-0.6297</td>\n",
              "      <td>0.6103</td>\n",
              "      <td>0.0223</td>\n",
              "      <td>-1.3240</td>\n",
              "      <td>-0.3174</td>\n",
              "      <td>-0.6417</td>\n",
              "      <td>-0.2187</td>\n",
              "      <td>-1.4080</td>\n",
              "      <td>0.6931</td>\n",
              "      <td>3</td>\n",
              "      <td>True</td>\n",
              "      <td>0.0</td>\n",
              "      <td>1.0</td>\n",
              "      <td>0.0</td>\n",
              "      <td>1.0</td>\n",
              "      <td>0.0</td>\n",
              "      <td>1.0</td>\n",
              "      <td>0.0</td>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>3</th>\n",
              "      <td>id_0015fd391</td>\n",
              "      <td>8c7f86626</td>\n",
              "      <td>-0.5138</td>\n",
              "      <td>-0.2491</td>\n",
              "      <td>-0.2656</td>\n",
              "      <td>0.5288</td>\n",
              "      <td>4.0620</td>\n",
              "      <td>-0.8095</td>\n",
              "      <td>-1.9590</td>\n",
              "      <td>0.1792</td>\n",
              "      <td>-0.1321</td>\n",
              "      <td>-1.0600</td>\n",
              "      <td>-0.8269</td>\n",
              "      <td>-0.3584</td>\n",
              "      <td>-0.8511</td>\n",
              "      <td>-0.5844</td>\n",
              "      <td>-2.5690</td>\n",
              "      <td>0.8183</td>\n",
              "      <td>-0.0532</td>\n",
              "      <td>-0.8554</td>\n",
              "      <td>0.1160</td>\n",
              "      <td>-2.3520</td>\n",
              "      <td>2.1200</td>\n",
              "      <td>-1.1580</td>\n",
              "      <td>-0.7191</td>\n",
              "      <td>-0.8004</td>\n",
              "      <td>-1.4670</td>\n",
              "      <td>-0.0107</td>\n",
              "      <td>-0.8995</td>\n",
              "      <td>0.2406</td>\n",
              "      <td>-0.2479</td>\n",
              "      <td>-1.0890</td>\n",
              "      <td>-0.7575</td>\n",
              "      <td>0.0881</td>\n",
              "      <td>-2.7370</td>\n",
              "      <td>0.8745</td>\n",
              "      <td>0.5787</td>\n",
              "      <td>-1.6740</td>\n",
              "      <td>-1.6720</td>\n",
              "      <td>-1.2690</td>\n",
              "      <td>...</td>\n",
              "      <td>-0.2990</td>\n",
              "      <td>-1.1870</td>\n",
              "      <td>-0.5044</td>\n",
              "      <td>-1.7750</td>\n",
              "      <td>-1.6120</td>\n",
              "      <td>-0.9215</td>\n",
              "      <td>-1.0810</td>\n",
              "      <td>-3.0520</td>\n",
              "      <td>-3.4470</td>\n",
              "      <td>-2.7740</td>\n",
              "      <td>-1.8460</td>\n",
              "      <td>-0.5568</td>\n",
              "      <td>-3.3960</td>\n",
              "      <td>-2.9510</td>\n",
              "      <td>-1.1550</td>\n",
              "      <td>-3.2620</td>\n",
              "      <td>-1.5390</td>\n",
              "      <td>-2.4600</td>\n",
              "      <td>-0.9417</td>\n",
              "      <td>-1.5550</td>\n",
              "      <td>0.2431</td>\n",
              "      <td>-2.0990</td>\n",
              "      <td>-0.6441</td>\n",
              "      <td>-5.6300</td>\n",
              "      <td>-1.3780</td>\n",
              "      <td>-0.8632</td>\n",
              "      <td>-1.2880</td>\n",
              "      <td>-1.6210</td>\n",
              "      <td>-0.8784</td>\n",
              "      <td>-0.3876</td>\n",
              "      <td>-0.8154</td>\n",
              "      <td>0</td>\n",
              "      <td>False</td>\n",
              "      <td>0.0</td>\n",
              "      <td>1.0</td>\n",
              "      <td>0.0</td>\n",
              "      <td>1.0</td>\n",
              "      <td>0.0</td>\n",
              "      <td>1.0</td>\n",
              "      <td>0.0</td>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>4</th>\n",
              "      <td>id_001626bd3</td>\n",
              "      <td>7cbed3131</td>\n",
              "      <td>-0.3254</td>\n",
              "      <td>-0.4009</td>\n",
              "      <td>0.9700</td>\n",
              "      <td>0.6919</td>\n",
              "      <td>1.4180</td>\n",
              "      <td>-0.8244</td>\n",
              "      <td>-0.2800</td>\n",
              "      <td>-0.1498</td>\n",
              "      <td>-0.8789</td>\n",
              "      <td>0.8630</td>\n",
              "      <td>-0.2219</td>\n",
              "      <td>-0.5121</td>\n",
              "      <td>-0.9577</td>\n",
              "      <td>1.1750</td>\n",
              "      <td>0.2042</td>\n",
              "      <td>0.1970</td>\n",
              "      <td>0.1244</td>\n",
              "      <td>-1.7090</td>\n",
              "      <td>-0.3543</td>\n",
              "      <td>-0.5160</td>\n",
              "      <td>-0.3330</td>\n",
              "      <td>-0.2685</td>\n",
              "      <td>0.7649</td>\n",
              "      <td>0.2057</td>\n",
              "      <td>1.3720</td>\n",
              "      <td>0.6835</td>\n",
              "      <td>0.8056</td>\n",
              "      <td>-0.3754</td>\n",
              "      <td>-1.2090</td>\n",
              "      <td>0.2965</td>\n",
              "      <td>-0.0712</td>\n",
              "      <td>0.6389</td>\n",
              "      <td>0.6674</td>\n",
              "      <td>-0.0783</td>\n",
              "      <td>1.1740</td>\n",
              "      <td>-0.7110</td>\n",
              "      <td>-1.4470</td>\n",
              "      <td>1.0620</td>\n",
              "      <td>...</td>\n",
              "      <td>0.6091</td>\n",
              "      <td>0.1813</td>\n",
              "      <td>-0.4249</td>\n",
              "      <td>0.7832</td>\n",
              "      <td>0.6529</td>\n",
              "      <td>0.5648</td>\n",
              "      <td>0.4817</td>\n",
              "      <td>0.0587</td>\n",
              "      <td>0.5303</td>\n",
              "      <td>0.6376</td>\n",
              "      <td>-0.3966</td>\n",
              "      <td>-1.4950</td>\n",
              "      <td>-0.9625</td>\n",
              "      <td>-0.0541</td>\n",
              "      <td>0.6273</td>\n",
              "      <td>0.4563</td>\n",
              "      <td>0.0698</td>\n",
              "      <td>0.8134</td>\n",
              "      <td>0.1924</td>\n",
              "      <td>0.6054</td>\n",
              "      <td>-0.1824</td>\n",
              "      <td>0.0042</td>\n",
              "      <td>0.0048</td>\n",
              "      <td>0.6670</td>\n",
              "      <td>1.0690</td>\n",
              "      <td>0.5523</td>\n",
              "      <td>-0.3031</td>\n",
              "      <td>0.1094</td>\n",
              "      <td>0.2885</td>\n",
              "      <td>-0.3786</td>\n",
              "      <td>0.7125</td>\n",
              "      <td>1</td>\n",
              "      <td>True</td>\n",
              "      <td>0.0</td>\n",
              "      <td>1.0</td>\n",
              "      <td>0.0</td>\n",
              "      <td>0.0</td>\n",
              "      <td>1.0</td>\n",
              "      <td>0.0</td>\n",
              "      <td>1.0</td>\n",
              "    </tr>\n",
              "  </tbody>\n",
              "</table>\n",
              "<p>5 rows × 883 columns</p>\n",
              "</div>"
            ],
            "text/plain": [
              "             id   composto      g0  ...  tempo_72  dose_D1  dose_D2\n",
              "0  id_000644bb2  b68db1d53  1.0620  ...       0.0      1.0      0.0\n",
              "1  id_000779bfc  df89a8e5a  0.0743  ...       1.0      1.0      0.0\n",
              "2  id_000a6266a  18bb41b2c  0.6280  ...       0.0      1.0      0.0\n",
              "3  id_0015fd391  8c7f86626 -0.5138  ...       0.0      1.0      0.0\n",
              "4  id_001626bd3  7cbed3131 -0.3254  ...       1.0      0.0      1.0\n",
              "\n",
              "[5 rows x 883 columns]"
            ]
          },
          "metadata": {
            "tags": []
          },
          "execution_count": 39
        }
      ]
    },
    {
      "cell_type": "markdown",
      "metadata": {
        "id": "Jdat2wceepwi"
      },
      "source": [
        "# Descobrindo quais Compostos foram mais Utilizados"
      ]
    },
    {
      "cell_type": "markdown",
      "metadata": {
        "id": "QNrXKWF9ijB1"
      },
      "source": [
        "**Agrupa em 'composto', agrega uma função de soma na coluna 'n_moa' e ordena em ordem decrescente**"
      ]
    },
    {
      "cell_type": "code",
      "metadata": {
        "id": "NBJQ0EBQPwsx",
        "colab": {
          "base_uri": "https://localhost:8080/",
          "height": 481
        },
        "outputId": "b0907d0d-3cc7-437c-a89e-eabba95ea386"
      },
      "source": [
        "dados_combinados.groupby(['composto']).agg({'n_moa' : ['sum']}).apply(lambda x: x.sort_values(ascending=False))"
      ],
      "execution_count": null,
      "outputs": [
        {
          "output_type": "execute_result",
          "data": {
            "text/html": [
              "<div>\n",
              "<style scoped>\n",
              "    .dataframe tbody tr th:only-of-type {\n",
              "        vertical-align: middle;\n",
              "    }\n",
              "\n",
              "    .dataframe tbody tr th {\n",
              "        vertical-align: top;\n",
              "    }\n",
              "\n",
              "    .dataframe thead tr th {\n",
              "        text-align: left;\n",
              "    }\n",
              "\n",
              "    .dataframe thead tr:last-of-type th {\n",
              "        text-align: right;\n",
              "    }\n",
              "</style>\n",
              "<table border=\"1\" class=\"dataframe\">\n",
              "  <thead>\n",
              "    <tr>\n",
              "      <th></th>\n",
              "      <th>n_moa</th>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th></th>\n",
              "      <th>sum</th>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>composto</th>\n",
              "      <th></th>\n",
              "    </tr>\n",
              "  </thead>\n",
              "  <tbody>\n",
              "    <tr>\n",
              "      <th>87d714366</th>\n",
              "      <td>1436</td>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>d50f18348</th>\n",
              "      <td>558</td>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>9f80f3f77</th>\n",
              "      <td>246</td>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>8b87a7a83</th>\n",
              "      <td>203</td>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>5628cb3ee</th>\n",
              "      <td>202</td>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>...</th>\n",
              "      <td>...</td>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>8be20f208</th>\n",
              "      <td>0</td>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>8c25111b8</th>\n",
              "      <td>0</td>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>8c48a42be</th>\n",
              "      <td>0</td>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>8c7b401c2</th>\n",
              "      <td>0</td>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>00199ff52</th>\n",
              "      <td>0</td>\n",
              "    </tr>\n",
              "  </tbody>\n",
              "</table>\n",
              "<p>3289 rows × 1 columns</p>\n",
              "</div>"
            ],
            "text/plain": [
              "          n_moa\n",
              "            sum\n",
              "composto       \n",
              "87d714366  1436\n",
              "d50f18348   558\n",
              "9f80f3f77   246\n",
              "8b87a7a83   203\n",
              "5628cb3ee   202\n",
              "...         ...\n",
              "8be20f208     0\n",
              "8c25111b8     0\n",
              "8c48a42be     0\n",
              "8c7b401c2     0\n",
              "00199ff52     0\n",
              "\n",
              "[3289 rows x 1 columns]"
            ]
          },
          "metadata": {
            "tags": []
          },
          "execution_count": 40
        }
      ]
    },
    {
      "cell_type": "markdown",
      "metadata": {
        "id": "SD9SKVtIiC2k"
      },
      "source": [
        "**Ao que pode ser visto na tabela acima, existe um composto que foi bastante usado**"
      ]
    },
    {
      "cell_type": "code",
      "metadata": {
        "id": "ZrSmompMfKem",
        "colab": {
          "base_uri": "https://localhost:8080/",
          "height": 439
        },
        "outputId": "2be98adf-87b7-4771-a7b7-9341e7e682dc"
      },
      "source": [
        "dados_combinados.query('composto == \"87d714366\"')"
      ],
      "execution_count": null,
      "outputs": [
        {
          "output_type": "execute_result",
          "data": {
            "text/html": [
              "<div>\n",
              "<style scoped>\n",
              "    .dataframe tbody tr th:only-of-type {\n",
              "        vertical-align: middle;\n",
              "    }\n",
              "\n",
              "    .dataframe tbody tr th {\n",
              "        vertical-align: top;\n",
              "    }\n",
              "\n",
              "    .dataframe thead th {\n",
              "        text-align: right;\n",
              "    }\n",
              "</style>\n",
              "<table border=\"1\" class=\"dataframe\">\n",
              "  <thead>\n",
              "    <tr style=\"text-align: right;\">\n",
              "      <th></th>\n",
              "      <th>id</th>\n",
              "      <th>composto</th>\n",
              "      <th>g0</th>\n",
              "      <th>g1</th>\n",
              "      <th>g2</th>\n",
              "      <th>g3</th>\n",
              "      <th>g4</th>\n",
              "      <th>g5</th>\n",
              "      <th>g6</th>\n",
              "      <th>g7</th>\n",
              "      <th>g8</th>\n",
              "      <th>g9</th>\n",
              "      <th>g10</th>\n",
              "      <th>g11</th>\n",
              "      <th>g12</th>\n",
              "      <th>g13</th>\n",
              "      <th>g14</th>\n",
              "      <th>g15</th>\n",
              "      <th>g16</th>\n",
              "      <th>g17</th>\n",
              "      <th>g18</th>\n",
              "      <th>g19</th>\n",
              "      <th>g20</th>\n",
              "      <th>g21</th>\n",
              "      <th>g22</th>\n",
              "      <th>g23</th>\n",
              "      <th>g24</th>\n",
              "      <th>g25</th>\n",
              "      <th>g26</th>\n",
              "      <th>g27</th>\n",
              "      <th>g28</th>\n",
              "      <th>g29</th>\n",
              "      <th>g30</th>\n",
              "      <th>g31</th>\n",
              "      <th>g32</th>\n",
              "      <th>g33</th>\n",
              "      <th>g34</th>\n",
              "      <th>g35</th>\n",
              "      <th>g36</th>\n",
              "      <th>g37</th>\n",
              "      <th>...</th>\n",
              "      <th>c69</th>\n",
              "      <th>c70</th>\n",
              "      <th>c71</th>\n",
              "      <th>c72</th>\n",
              "      <th>c73</th>\n",
              "      <th>c74</th>\n",
              "      <th>c75</th>\n",
              "      <th>c76</th>\n",
              "      <th>c77</th>\n",
              "      <th>c78</th>\n",
              "      <th>c79</th>\n",
              "      <th>c80</th>\n",
              "      <th>c81</th>\n",
              "      <th>c82</th>\n",
              "      <th>c83</th>\n",
              "      <th>c84</th>\n",
              "      <th>c85</th>\n",
              "      <th>c86</th>\n",
              "      <th>c87</th>\n",
              "      <th>c88</th>\n",
              "      <th>c89</th>\n",
              "      <th>c90</th>\n",
              "      <th>c91</th>\n",
              "      <th>c92</th>\n",
              "      <th>c93</th>\n",
              "      <th>c94</th>\n",
              "      <th>c95</th>\n",
              "      <th>c96</th>\n",
              "      <th>c97</th>\n",
              "      <th>c98</th>\n",
              "      <th>c99</th>\n",
              "      <th>n_moa</th>\n",
              "      <th>ativo_moa</th>\n",
              "      <th>tratamento_com_controle</th>\n",
              "      <th>tratamento_com_droga</th>\n",
              "      <th>tempo_24</th>\n",
              "      <th>tempo_48</th>\n",
              "      <th>tempo_72</th>\n",
              "      <th>dose_D1</th>\n",
              "      <th>dose_D2</th>\n",
              "    </tr>\n",
              "  </thead>\n",
              "  <tbody>\n",
              "    <tr>\n",
              "      <th>16</th>\n",
              "      <td>id_002fb9c19</td>\n",
              "      <td>87d714366</td>\n",
              "      <td>8.738</td>\n",
              "      <td>0.1914</td>\n",
              "      <td>2.4380</td>\n",
              "      <td>-0.2930</td>\n",
              "      <td>3.2010</td>\n",
              "      <td>1.4910</td>\n",
              "      <td>5.3920</td>\n",
              "      <td>-1.0420</td>\n",
              "      <td>-8.486</td>\n",
              "      <td>-2.5790</td>\n",
              "      <td>-6.747</td>\n",
              "      <td>3.6150</td>\n",
              "      <td>-1.4510</td>\n",
              "      <td>0.6909</td>\n",
              "      <td>-0.7623</td>\n",
              "      <td>-2.9400</td>\n",
              "      <td>-9.285</td>\n",
              "      <td>-6.7110</td>\n",
              "      <td>-0.4195</td>\n",
              "      <td>1.1600</td>\n",
              "      <td>-1.3180</td>\n",
              "      <td>1.3660</td>\n",
              "      <td>-1.4020</td>\n",
              "      <td>-2.6220</td>\n",
              "      <td>0.7204</td>\n",
              "      <td>-2.5930</td>\n",
              "      <td>-4.063</td>\n",
              "      <td>-0.8282</td>\n",
              "      <td>-3.500</td>\n",
              "      <td>0.9206</td>\n",
              "      <td>-5.145</td>\n",
              "      <td>9.804</td>\n",
              "      <td>-2.6840</td>\n",
              "      <td>-2.4390</td>\n",
              "      <td>-0.1427</td>\n",
              "      <td>4.2830</td>\n",
              "      <td>0.8084</td>\n",
              "      <td>-7.365</td>\n",
              "      <td>...</td>\n",
              "      <td>-8.887</td>\n",
              "      <td>-10.000</td>\n",
              "      <td>-10.000</td>\n",
              "      <td>-10.000</td>\n",
              "      <td>-10.000</td>\n",
              "      <td>-4.902</td>\n",
              "      <td>-9.984</td>\n",
              "      <td>-5.552</td>\n",
              "      <td>-9.984</td>\n",
              "      <td>-9.984</td>\n",
              "      <td>-9.984</td>\n",
              "      <td>-9.984</td>\n",
              "      <td>-9.984</td>\n",
              "      <td>-9.984</td>\n",
              "      <td>-9.984</td>\n",
              "      <td>-9.984</td>\n",
              "      <td>-9.984</td>\n",
              "      <td>-9.796</td>\n",
              "      <td>-8.177</td>\n",
              "      <td>-9.899</td>\n",
              "      <td>-9.984</td>\n",
              "      <td>-9.984</td>\n",
              "      <td>-9.984</td>\n",
              "      <td>-9.984</td>\n",
              "      <td>-9.984</td>\n",
              "      <td>-9.984</td>\n",
              "      <td>-9.984</td>\n",
              "      <td>-9.984</td>\n",
              "      <td>-9.984</td>\n",
              "      <td>-9.984</td>\n",
              "      <td>-6.784</td>\n",
              "      <td>2</td>\n",
              "      <td>True</td>\n",
              "      <td>0.0</td>\n",
              "      <td>1.0</td>\n",
              "      <td>0.0</td>\n",
              "      <td>1.0</td>\n",
              "      <td>0.0</td>\n",
              "      <td>1.0</td>\n",
              "      <td>0.0</td>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>76</th>\n",
              "      <td>id_00cf039a7</td>\n",
              "      <td>87d714366</td>\n",
              "      <td>4.546</td>\n",
              "      <td>0.4257</td>\n",
              "      <td>0.7670</td>\n",
              "      <td>2.1950</td>\n",
              "      <td>2.5960</td>\n",
              "      <td>0.3677</td>\n",
              "      <td>-0.3854</td>\n",
              "      <td>-1.1590</td>\n",
              "      <td>-8.180</td>\n",
              "      <td>-2.1310</td>\n",
              "      <td>-4.168</td>\n",
              "      <td>2.5630</td>\n",
              "      <td>-1.3410</td>\n",
              "      <td>5.2610</td>\n",
              "      <td>-2.5680</td>\n",
              "      <td>1.0840</td>\n",
              "      <td>-3.835</td>\n",
              "      <td>-4.8440</td>\n",
              "      <td>0.8522</td>\n",
              "      <td>0.2435</td>\n",
              "      <td>-2.6090</td>\n",
              "      <td>0.3067</td>\n",
              "      <td>0.9733</td>\n",
              "      <td>-1.6080</td>\n",
              "      <td>-2.9210</td>\n",
              "      <td>-1.9570</td>\n",
              "      <td>-2.644</td>\n",
              "      <td>2.4030</td>\n",
              "      <td>-3.036</td>\n",
              "      <td>-6.4520</td>\n",
              "      <td>-3.258</td>\n",
              "      <td>4.355</td>\n",
              "      <td>-0.7562</td>\n",
              "      <td>0.9930</td>\n",
              "      <td>-0.2854</td>\n",
              "      <td>1.4000</td>\n",
              "      <td>-0.5551</td>\n",
              "      <td>-8.016</td>\n",
              "      <td>...</td>\n",
              "      <td>-6.254</td>\n",
              "      <td>-9.995</td>\n",
              "      <td>-6.955</td>\n",
              "      <td>-9.995</td>\n",
              "      <td>-9.743</td>\n",
              "      <td>-3.457</td>\n",
              "      <td>-8.712</td>\n",
              "      <td>-3.972</td>\n",
              "      <td>-8.709</td>\n",
              "      <td>-10.000</td>\n",
              "      <td>-8.461</td>\n",
              "      <td>-9.347</td>\n",
              "      <td>-8.698</td>\n",
              "      <td>-9.807</td>\n",
              "      <td>-10.000</td>\n",
              "      <td>-10.000</td>\n",
              "      <td>-10.000</td>\n",
              "      <td>-5.657</td>\n",
              "      <td>-5.513</td>\n",
              "      <td>-8.284</td>\n",
              "      <td>-9.490</td>\n",
              "      <td>-8.729</td>\n",
              "      <td>-10.000</td>\n",
              "      <td>-7.834</td>\n",
              "      <td>-9.538</td>\n",
              "      <td>-10.000</td>\n",
              "      <td>-8.520</td>\n",
              "      <td>-10.000</td>\n",
              "      <td>-7.436</td>\n",
              "      <td>-6.918</td>\n",
              "      <td>-5.235</td>\n",
              "      <td>2</td>\n",
              "      <td>True</td>\n",
              "      <td>0.0</td>\n",
              "      <td>1.0</td>\n",
              "      <td>0.0</td>\n",
              "      <td>1.0</td>\n",
              "      <td>0.0</td>\n",
              "      <td>0.0</td>\n",
              "      <td>1.0</td>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>119</th>\n",
              "      <td>id_01534c4ee</td>\n",
              "      <td>87d714366</td>\n",
              "      <td>10.000</td>\n",
              "      <td>-1.2200</td>\n",
              "      <td>1.5150</td>\n",
              "      <td>-2.1910</td>\n",
              "      <td>4.3530</td>\n",
              "      <td>-0.9594</td>\n",
              "      <td>2.5600</td>\n",
              "      <td>-3.3120</td>\n",
              "      <td>-9.507</td>\n",
              "      <td>-3.3930</td>\n",
              "      <td>-4.160</td>\n",
              "      <td>-2.9320</td>\n",
              "      <td>0.0000</td>\n",
              "      <td>2.2650</td>\n",
              "      <td>-6.2560</td>\n",
              "      <td>0.1147</td>\n",
              "      <td>-4.209</td>\n",
              "      <td>-3.5580</td>\n",
              "      <td>3.2920</td>\n",
              "      <td>0.1551</td>\n",
              "      <td>-3.7200</td>\n",
              "      <td>0.1069</td>\n",
              "      <td>1.3000</td>\n",
              "      <td>1.9710</td>\n",
              "      <td>-9.9350</td>\n",
              "      <td>-1.8340</td>\n",
              "      <td>-1.072</td>\n",
              "      <td>0.2092</td>\n",
              "      <td>-1.989</td>\n",
              "      <td>-4.0390</td>\n",
              "      <td>-6.047</td>\n",
              "      <td>8.404</td>\n",
              "      <td>3.1040</td>\n",
              "      <td>-3.3390</td>\n",
              "      <td>-2.8780</td>\n",
              "      <td>0.6408</td>\n",
              "      <td>3.5500</td>\n",
              "      <td>-4.652</td>\n",
              "      <td>...</td>\n",
              "      <td>-6.568</td>\n",
              "      <td>-9.978</td>\n",
              "      <td>-8.664</td>\n",
              "      <td>-9.978</td>\n",
              "      <td>-9.978</td>\n",
              "      <td>-4.073</td>\n",
              "      <td>-10.000</td>\n",
              "      <td>-5.163</td>\n",
              "      <td>-7.797</td>\n",
              "      <td>-10.000</td>\n",
              "      <td>-8.297</td>\n",
              "      <td>-10.000</td>\n",
              "      <td>-10.000</td>\n",
              "      <td>-10.000</td>\n",
              "      <td>-10.000</td>\n",
              "      <td>-10.000</td>\n",
              "      <td>-10.000</td>\n",
              "      <td>-8.019</td>\n",
              "      <td>-8.688</td>\n",
              "      <td>-9.658</td>\n",
              "      <td>-9.308</td>\n",
              "      <td>-10.000</td>\n",
              "      <td>-10.000</td>\n",
              "      <td>-7.703</td>\n",
              "      <td>-10.000</td>\n",
              "      <td>-10.000</td>\n",
              "      <td>-9.054</td>\n",
              "      <td>-10.000</td>\n",
              "      <td>-8.771</td>\n",
              "      <td>-9.694</td>\n",
              "      <td>-5.548</td>\n",
              "      <td>2</td>\n",
              "      <td>True</td>\n",
              "      <td>0.0</td>\n",
              "      <td>1.0</td>\n",
              "      <td>0.0</td>\n",
              "      <td>0.0</td>\n",
              "      <td>1.0</td>\n",
              "      <td>0.0</td>\n",
              "      <td>1.0</td>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>209</th>\n",
              "      <td>id_0236e3425</td>\n",
              "      <td>87d714366</td>\n",
              "      <td>3.612</td>\n",
              "      <td>-1.7130</td>\n",
              "      <td>0.0313</td>\n",
              "      <td>-1.7360</td>\n",
              "      <td>3.3550</td>\n",
              "      <td>-1.7040</td>\n",
              "      <td>2.6010</td>\n",
              "      <td>-1.4530</td>\n",
              "      <td>-9.534</td>\n",
              "      <td>-2.8730</td>\n",
              "      <td>-4.465</td>\n",
              "      <td>-0.4308</td>\n",
              "      <td>-1.7920</td>\n",
              "      <td>3.8900</td>\n",
              "      <td>-3.4910</td>\n",
              "      <td>0.6124</td>\n",
              "      <td>-3.504</td>\n",
              "      <td>-4.4450</td>\n",
              "      <td>-1.4690</td>\n",
              "      <td>-2.8590</td>\n",
              "      <td>-1.4090</td>\n",
              "      <td>0.1560</td>\n",
              "      <td>-3.1610</td>\n",
              "      <td>-1.5710</td>\n",
              "      <td>0.0587</td>\n",
              "      <td>-0.0839</td>\n",
              "      <td>-3.619</td>\n",
              "      <td>-0.2986</td>\n",
              "      <td>-2.164</td>\n",
              "      <td>-2.1390</td>\n",
              "      <td>-3.929</td>\n",
              "      <td>7.451</td>\n",
              "      <td>-1.0450</td>\n",
              "      <td>4.2260</td>\n",
              "      <td>-3.5800</td>\n",
              "      <td>2.5210</td>\n",
              "      <td>0.5612</td>\n",
              "      <td>-6.335</td>\n",
              "      <td>...</td>\n",
              "      <td>-7.088</td>\n",
              "      <td>-10.000</td>\n",
              "      <td>-10.000</td>\n",
              "      <td>-10.000</td>\n",
              "      <td>-10.000</td>\n",
              "      <td>-4.432</td>\n",
              "      <td>-10.000</td>\n",
              "      <td>-6.025</td>\n",
              "      <td>-8.882</td>\n",
              "      <td>-10.000</td>\n",
              "      <td>-8.023</td>\n",
              "      <td>-10.000</td>\n",
              "      <td>-10.000</td>\n",
              "      <td>-10.000</td>\n",
              "      <td>-10.000</td>\n",
              "      <td>-10.000</td>\n",
              "      <td>-10.000</td>\n",
              "      <td>-8.517</td>\n",
              "      <td>-7.589</td>\n",
              "      <td>-10.000</td>\n",
              "      <td>-10.000</td>\n",
              "      <td>-10.000</td>\n",
              "      <td>-10.000</td>\n",
              "      <td>-8.451</td>\n",
              "      <td>-10.000</td>\n",
              "      <td>-10.000</td>\n",
              "      <td>-8.695</td>\n",
              "      <td>-10.000</td>\n",
              "      <td>-8.559</td>\n",
              "      <td>-8.025</td>\n",
              "      <td>-6.642</td>\n",
              "      <td>2</td>\n",
              "      <td>True</td>\n",
              "      <td>0.0</td>\n",
              "      <td>1.0</td>\n",
              "      <td>0.0</td>\n",
              "      <td>0.0</td>\n",
              "      <td>1.0</td>\n",
              "      <td>1.0</td>\n",
              "      <td>0.0</td>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>218</th>\n",
              "      <td>id_024a52260</td>\n",
              "      <td>87d714366</td>\n",
              "      <td>2.119</td>\n",
              "      <td>0.1098</td>\n",
              "      <td>1.1040</td>\n",
              "      <td>5.0620</td>\n",
              "      <td>-0.7427</td>\n",
              "      <td>-0.3564</td>\n",
              "      <td>-0.8253</td>\n",
              "      <td>-3.6180</td>\n",
              "      <td>-1.127</td>\n",
              "      <td>-2.1360</td>\n",
              "      <td>-3.371</td>\n",
              "      <td>5.4820</td>\n",
              "      <td>0.0537</td>\n",
              "      <td>8.0940</td>\n",
              "      <td>-1.3650</td>\n",
              "      <td>-1.4740</td>\n",
              "      <td>-4.195</td>\n",
              "      <td>0.0338</td>\n",
              "      <td>-0.2759</td>\n",
              "      <td>0.3821</td>\n",
              "      <td>-0.6859</td>\n",
              "      <td>-2.6870</td>\n",
              "      <td>0.1784</td>\n",
              "      <td>-1.0710</td>\n",
              "      <td>-4.1710</td>\n",
              "      <td>1.5710</td>\n",
              "      <td>-1.949</td>\n",
              "      <td>-1.0180</td>\n",
              "      <td>-4.791</td>\n",
              "      <td>-5.3540</td>\n",
              "      <td>-5.922</td>\n",
              "      <td>2.569</td>\n",
              "      <td>-1.5100</td>\n",
              "      <td>-2.7960</td>\n",
              "      <td>3.0740</td>\n",
              "      <td>-0.3863</td>\n",
              "      <td>-5.7270</td>\n",
              "      <td>-10.000</td>\n",
              "      <td>...</td>\n",
              "      <td>-4.503</td>\n",
              "      <td>-10.000</td>\n",
              "      <td>-5.367</td>\n",
              "      <td>-5.762</td>\n",
              "      <td>-5.173</td>\n",
              "      <td>-1.988</td>\n",
              "      <td>-7.265</td>\n",
              "      <td>-6.189</td>\n",
              "      <td>-5.044</td>\n",
              "      <td>-8.035</td>\n",
              "      <td>-4.652</td>\n",
              "      <td>-4.068</td>\n",
              "      <td>-6.564</td>\n",
              "      <td>-5.805</td>\n",
              "      <td>-8.420</td>\n",
              "      <td>-5.524</td>\n",
              "      <td>-6.696</td>\n",
              "      <td>-2.777</td>\n",
              "      <td>-3.348</td>\n",
              "      <td>-4.720</td>\n",
              "      <td>-5.357</td>\n",
              "      <td>-8.619</td>\n",
              "      <td>-7.332</td>\n",
              "      <td>-7.828</td>\n",
              "      <td>-9.679</td>\n",
              "      <td>-8.439</td>\n",
              "      <td>-2.047</td>\n",
              "      <td>-7.430</td>\n",
              "      <td>-5.861</td>\n",
              "      <td>-4.591</td>\n",
              "      <td>-3.533</td>\n",
              "      <td>2</td>\n",
              "      <td>True</td>\n",
              "      <td>0.0</td>\n",
              "      <td>1.0</td>\n",
              "      <td>1.0</td>\n",
              "      <td>0.0</td>\n",
              "      <td>0.0</td>\n",
              "      <td>0.0</td>\n",
              "      <td>1.0</td>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>...</th>\n",
              "      <td>...</td>\n",
              "      <td>...</td>\n",
              "      <td>...</td>\n",
              "      <td>...</td>\n",
              "      <td>...</td>\n",
              "      <td>...</td>\n",
              "      <td>...</td>\n",
              "      <td>...</td>\n",
              "      <td>...</td>\n",
              "      <td>...</td>\n",
              "      <td>...</td>\n",
              "      <td>...</td>\n",
              "      <td>...</td>\n",
              "      <td>...</td>\n",
              "      <td>...</td>\n",
              "      <td>...</td>\n",
              "      <td>...</td>\n",
              "      <td>...</td>\n",
              "      <td>...</td>\n",
              "      <td>...</td>\n",
              "      <td>...</td>\n",
              "      <td>...</td>\n",
              "      <td>...</td>\n",
              "      <td>...</td>\n",
              "      <td>...</td>\n",
              "      <td>...</td>\n",
              "      <td>...</td>\n",
              "      <td>...</td>\n",
              "      <td>...</td>\n",
              "      <td>...</td>\n",
              "      <td>...</td>\n",
              "      <td>...</td>\n",
              "      <td>...</td>\n",
              "      <td>...</td>\n",
              "      <td>...</td>\n",
              "      <td>...</td>\n",
              "      <td>...</td>\n",
              "      <td>...</td>\n",
              "      <td>...</td>\n",
              "      <td>...</td>\n",
              "      <td>...</td>\n",
              "      <td>...</td>\n",
              "      <td>...</td>\n",
              "      <td>...</td>\n",
              "      <td>...</td>\n",
              "      <td>...</td>\n",
              "      <td>...</td>\n",
              "      <td>...</td>\n",
              "      <td>...</td>\n",
              "      <td>...</td>\n",
              "      <td>...</td>\n",
              "      <td>...</td>\n",
              "      <td>...</td>\n",
              "      <td>...</td>\n",
              "      <td>...</td>\n",
              "      <td>...</td>\n",
              "      <td>...</td>\n",
              "      <td>...</td>\n",
              "      <td>...</td>\n",
              "      <td>...</td>\n",
              "      <td>...</td>\n",
              "      <td>...</td>\n",
              "      <td>...</td>\n",
              "      <td>...</td>\n",
              "      <td>...</td>\n",
              "      <td>...</td>\n",
              "      <td>...</td>\n",
              "      <td>...</td>\n",
              "      <td>...</td>\n",
              "      <td>...</td>\n",
              "      <td>...</td>\n",
              "      <td>...</td>\n",
              "      <td>...</td>\n",
              "      <td>...</td>\n",
              "      <td>...</td>\n",
              "      <td>...</td>\n",
              "      <td>...</td>\n",
              "      <td>...</td>\n",
              "      <td>...</td>\n",
              "      <td>...</td>\n",
              "      <td>...</td>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>23680</th>\n",
              "      <td>id_fe8abffe0</td>\n",
              "      <td>87d714366</td>\n",
              "      <td>6.649</td>\n",
              "      <td>-0.4462</td>\n",
              "      <td>1.7370</td>\n",
              "      <td>0.0553</td>\n",
              "      <td>3.0330</td>\n",
              "      <td>-2.7360</td>\n",
              "      <td>0.4016</td>\n",
              "      <td>-4.5340</td>\n",
              "      <td>-9.746</td>\n",
              "      <td>-3.1160</td>\n",
              "      <td>-5.381</td>\n",
              "      <td>2.1980</td>\n",
              "      <td>-1.4490</td>\n",
              "      <td>6.8380</td>\n",
              "      <td>-5.0190</td>\n",
              "      <td>0.7382</td>\n",
              "      <td>-4.690</td>\n",
              "      <td>-4.5760</td>\n",
              "      <td>-1.5880</td>\n",
              "      <td>-3.1120</td>\n",
              "      <td>-5.5090</td>\n",
              "      <td>-1.4490</td>\n",
              "      <td>-2.2670</td>\n",
              "      <td>-1.7240</td>\n",
              "      <td>-1.2190</td>\n",
              "      <td>-2.5050</td>\n",
              "      <td>-5.049</td>\n",
              "      <td>0.9918</td>\n",
              "      <td>-4.635</td>\n",
              "      <td>-1.8910</td>\n",
              "      <td>-3.750</td>\n",
              "      <td>4.339</td>\n",
              "      <td>-0.5515</td>\n",
              "      <td>7.0970</td>\n",
              "      <td>-2.5690</td>\n",
              "      <td>1.3340</td>\n",
              "      <td>-0.4405</td>\n",
              "      <td>-10.000</td>\n",
              "      <td>...</td>\n",
              "      <td>-8.596</td>\n",
              "      <td>-10.000</td>\n",
              "      <td>-10.000</td>\n",
              "      <td>-10.000</td>\n",
              "      <td>-10.000</td>\n",
              "      <td>-5.098</td>\n",
              "      <td>-9.910</td>\n",
              "      <td>-5.222</td>\n",
              "      <td>-9.910</td>\n",
              "      <td>-9.910</td>\n",
              "      <td>-9.910</td>\n",
              "      <td>-9.910</td>\n",
              "      <td>-9.910</td>\n",
              "      <td>-9.910</td>\n",
              "      <td>-9.910</td>\n",
              "      <td>-9.910</td>\n",
              "      <td>-8.969</td>\n",
              "      <td>-9.910</td>\n",
              "      <td>-9.152</td>\n",
              "      <td>-9.432</td>\n",
              "      <td>-8.110</td>\n",
              "      <td>-9.910</td>\n",
              "      <td>-9.910</td>\n",
              "      <td>-9.910</td>\n",
              "      <td>-9.910</td>\n",
              "      <td>-9.910</td>\n",
              "      <td>-9.910</td>\n",
              "      <td>-9.910</td>\n",
              "      <td>-8.830</td>\n",
              "      <td>-9.910</td>\n",
              "      <td>-7.807</td>\n",
              "      <td>2</td>\n",
              "      <td>True</td>\n",
              "      <td>0.0</td>\n",
              "      <td>1.0</td>\n",
              "      <td>0.0</td>\n",
              "      <td>0.0</td>\n",
              "      <td>1.0</td>\n",
              "      <td>1.0</td>\n",
              "      <td>0.0</td>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>23727</th>\n",
              "      <td>id_ff1d43f96</td>\n",
              "      <td>87d714366</td>\n",
              "      <td>3.263</td>\n",
              "      <td>1.4620</td>\n",
              "      <td>0.2311</td>\n",
              "      <td>3.3590</td>\n",
              "      <td>1.7250</td>\n",
              "      <td>0.4117</td>\n",
              "      <td>-0.4033</td>\n",
              "      <td>-0.6053</td>\n",
              "      <td>-3.445</td>\n",
              "      <td>-1.5280</td>\n",
              "      <td>-3.771</td>\n",
              "      <td>6.1560</td>\n",
              "      <td>1.4140</td>\n",
              "      <td>6.3520</td>\n",
              "      <td>0.2650</td>\n",
              "      <td>-1.3610</td>\n",
              "      <td>-4.642</td>\n",
              "      <td>-2.8910</td>\n",
              "      <td>0.6158</td>\n",
              "      <td>1.5470</td>\n",
              "      <td>-3.2930</td>\n",
              "      <td>0.3337</td>\n",
              "      <td>-0.6316</td>\n",
              "      <td>-2.0770</td>\n",
              "      <td>0.7569</td>\n",
              "      <td>0.7684</td>\n",
              "      <td>-3.064</td>\n",
              "      <td>-1.4090</td>\n",
              "      <td>-4.214</td>\n",
              "      <td>-5.5860</td>\n",
              "      <td>-4.665</td>\n",
              "      <td>1.429</td>\n",
              "      <td>0.2997</td>\n",
              "      <td>-2.0450</td>\n",
              "      <td>1.8980</td>\n",
              "      <td>-2.3790</td>\n",
              "      <td>-7.3700</td>\n",
              "      <td>-10.000</td>\n",
              "      <td>...</td>\n",
              "      <td>-4.248</td>\n",
              "      <td>-9.957</td>\n",
              "      <td>-5.353</td>\n",
              "      <td>-7.343</td>\n",
              "      <td>-5.936</td>\n",
              "      <td>-3.006</td>\n",
              "      <td>-8.881</td>\n",
              "      <td>-4.543</td>\n",
              "      <td>-6.545</td>\n",
              "      <td>-8.181</td>\n",
              "      <td>-4.239</td>\n",
              "      <td>-4.828</td>\n",
              "      <td>-5.770</td>\n",
              "      <td>-5.915</td>\n",
              "      <td>-8.183</td>\n",
              "      <td>-4.614</td>\n",
              "      <td>-5.767</td>\n",
              "      <td>-4.699</td>\n",
              "      <td>-4.526</td>\n",
              "      <td>-4.098</td>\n",
              "      <td>-5.579</td>\n",
              "      <td>-8.000</td>\n",
              "      <td>-9.344</td>\n",
              "      <td>-7.395</td>\n",
              "      <td>-10.000</td>\n",
              "      <td>-7.359</td>\n",
              "      <td>-1.574</td>\n",
              "      <td>-6.896</td>\n",
              "      <td>-5.001</td>\n",
              "      <td>-4.139</td>\n",
              "      <td>-3.271</td>\n",
              "      <td>2</td>\n",
              "      <td>True</td>\n",
              "      <td>0.0</td>\n",
              "      <td>1.0</td>\n",
              "      <td>1.0</td>\n",
              "      <td>0.0</td>\n",
              "      <td>0.0</td>\n",
              "      <td>0.0</td>\n",
              "      <td>1.0</td>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>23776</th>\n",
              "      <td>id_ff9d0a022</td>\n",
              "      <td>87d714366</td>\n",
              "      <td>1.227</td>\n",
              "      <td>0.3781</td>\n",
              "      <td>2.8860</td>\n",
              "      <td>7.1470</td>\n",
              "      <td>-0.4875</td>\n",
              "      <td>-1.2070</td>\n",
              "      <td>0.7124</td>\n",
              "      <td>-2.9770</td>\n",
              "      <td>-2.879</td>\n",
              "      <td>0.8712</td>\n",
              "      <td>10.000</td>\n",
              "      <td>5.5150</td>\n",
              "      <td>-1.9930</td>\n",
              "      <td>5.1930</td>\n",
              "      <td>-0.6509</td>\n",
              "      <td>-1.5610</td>\n",
              "      <td>-1.137</td>\n",
              "      <td>-1.4880</td>\n",
              "      <td>0.2867</td>\n",
              "      <td>0.2786</td>\n",
              "      <td>-0.9956</td>\n",
              "      <td>-1.3100</td>\n",
              "      <td>-0.6124</td>\n",
              "      <td>-1.4480</td>\n",
              "      <td>-3.2240</td>\n",
              "      <td>1.0280</td>\n",
              "      <td>-1.423</td>\n",
              "      <td>-2.7110</td>\n",
              "      <td>-4.183</td>\n",
              "      <td>-3.8860</td>\n",
              "      <td>-5.463</td>\n",
              "      <td>3.662</td>\n",
              "      <td>-1.1530</td>\n",
              "      <td>-1.2060</td>\n",
              "      <td>3.5390</td>\n",
              "      <td>-1.1970</td>\n",
              "      <td>-6.4920</td>\n",
              "      <td>-10.000</td>\n",
              "      <td>...</td>\n",
              "      <td>-5.493</td>\n",
              "      <td>-9.657</td>\n",
              "      <td>-5.448</td>\n",
              "      <td>-8.192</td>\n",
              "      <td>-5.703</td>\n",
              "      <td>-2.689</td>\n",
              "      <td>-7.787</td>\n",
              "      <td>-7.416</td>\n",
              "      <td>-4.585</td>\n",
              "      <td>-8.108</td>\n",
              "      <td>-4.620</td>\n",
              "      <td>-7.661</td>\n",
              "      <td>-8.309</td>\n",
              "      <td>-6.302</td>\n",
              "      <td>-9.355</td>\n",
              "      <td>-5.185</td>\n",
              "      <td>-8.082</td>\n",
              "      <td>-3.078</td>\n",
              "      <td>-3.840</td>\n",
              "      <td>-5.908</td>\n",
              "      <td>-5.867</td>\n",
              "      <td>-10.000</td>\n",
              "      <td>-9.328</td>\n",
              "      <td>-7.380</td>\n",
              "      <td>-10.000</td>\n",
              "      <td>-8.754</td>\n",
              "      <td>-1.938</td>\n",
              "      <td>-7.529</td>\n",
              "      <td>-6.318</td>\n",
              "      <td>-5.701</td>\n",
              "      <td>-3.561</td>\n",
              "      <td>2</td>\n",
              "      <td>True</td>\n",
              "      <td>0.0</td>\n",
              "      <td>1.0</td>\n",
              "      <td>1.0</td>\n",
              "      <td>0.0</td>\n",
              "      <td>0.0</td>\n",
              "      <td>0.0</td>\n",
              "      <td>1.0</td>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>23791</th>\n",
              "      <td>id_ffd1fd119</td>\n",
              "      <td>87d714366</td>\n",
              "      <td>5.312</td>\n",
              "      <td>0.4505</td>\n",
              "      <td>1.5320</td>\n",
              "      <td>0.8226</td>\n",
              "      <td>3.0250</td>\n",
              "      <td>-0.4502</td>\n",
              "      <td>-0.8196</td>\n",
              "      <td>-1.7550</td>\n",
              "      <td>-9.205</td>\n",
              "      <td>-2.4890</td>\n",
              "      <td>-2.743</td>\n",
              "      <td>0.3039</td>\n",
              "      <td>-3.1820</td>\n",
              "      <td>3.7120</td>\n",
              "      <td>-3.5190</td>\n",
              "      <td>1.3900</td>\n",
              "      <td>-2.796</td>\n",
              "      <td>-4.3670</td>\n",
              "      <td>-1.6070</td>\n",
              "      <td>0.6094</td>\n",
              "      <td>-5.0060</td>\n",
              "      <td>-0.6930</td>\n",
              "      <td>1.2240</td>\n",
              "      <td>0.5679</td>\n",
              "      <td>-3.9940</td>\n",
              "      <td>-3.0080</td>\n",
              "      <td>-1.883</td>\n",
              "      <td>3.5390</td>\n",
              "      <td>-2.899</td>\n",
              "      <td>-9.0610</td>\n",
              "      <td>-5.198</td>\n",
              "      <td>5.802</td>\n",
              "      <td>1.3620</td>\n",
              "      <td>0.8115</td>\n",
              "      <td>-2.0090</td>\n",
              "      <td>7.0420</td>\n",
              "      <td>1.3500</td>\n",
              "      <td>-8.052</td>\n",
              "      <td>...</td>\n",
              "      <td>-7.790</td>\n",
              "      <td>-10.000</td>\n",
              "      <td>-9.802</td>\n",
              "      <td>-10.000</td>\n",
              "      <td>-10.000</td>\n",
              "      <td>-5.340</td>\n",
              "      <td>-9.852</td>\n",
              "      <td>-8.071</td>\n",
              "      <td>-8.019</td>\n",
              "      <td>-9.966</td>\n",
              "      <td>-9.410</td>\n",
              "      <td>-9.966</td>\n",
              "      <td>-9.817</td>\n",
              "      <td>-9.966</td>\n",
              "      <td>-9.966</td>\n",
              "      <td>-9.966</td>\n",
              "      <td>-9.966</td>\n",
              "      <td>-8.638</td>\n",
              "      <td>-8.966</td>\n",
              "      <td>-9.171</td>\n",
              "      <td>-8.631</td>\n",
              "      <td>-9.966</td>\n",
              "      <td>-9.966</td>\n",
              "      <td>-9.220</td>\n",
              "      <td>-9.373</td>\n",
              "      <td>-9.966</td>\n",
              "      <td>-9.362</td>\n",
              "      <td>-9.966</td>\n",
              "      <td>-8.642</td>\n",
              "      <td>-9.966</td>\n",
              "      <td>-4.605</td>\n",
              "      <td>2</td>\n",
              "      <td>True</td>\n",
              "      <td>0.0</td>\n",
              "      <td>1.0</td>\n",
              "      <td>0.0</td>\n",
              "      <td>0.0</td>\n",
              "      <td>1.0</td>\n",
              "      <td>0.0</td>\n",
              "      <td>1.0</td>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>23802</th>\n",
              "      <td>id_fff3976bd</td>\n",
              "      <td>87d714366</td>\n",
              "      <td>3.289</td>\n",
              "      <td>2.1270</td>\n",
              "      <td>0.9770</td>\n",
              "      <td>2.0490</td>\n",
              "      <td>2.3170</td>\n",
              "      <td>-0.5355</td>\n",
              "      <td>-0.6357</td>\n",
              "      <td>-6.9060</td>\n",
              "      <td>-4.483</td>\n",
              "      <td>-2.8400</td>\n",
              "      <td>-5.331</td>\n",
              "      <td>0.6547</td>\n",
              "      <td>-2.2080</td>\n",
              "      <td>3.6030</td>\n",
              "      <td>0.6380</td>\n",
              "      <td>-2.1280</td>\n",
              "      <td>-3.168</td>\n",
              "      <td>-4.2180</td>\n",
              "      <td>-0.3170</td>\n",
              "      <td>0.2140</td>\n",
              "      <td>-1.7660</td>\n",
              "      <td>-1.9700</td>\n",
              "      <td>-1.4820</td>\n",
              "      <td>-1.3710</td>\n",
              "      <td>-0.2628</td>\n",
              "      <td>-0.5276</td>\n",
              "      <td>-2.416</td>\n",
              "      <td>-0.4638</td>\n",
              "      <td>-3.863</td>\n",
              "      <td>-0.8880</td>\n",
              "      <td>-1.985</td>\n",
              "      <td>2.053</td>\n",
              "      <td>-1.4700</td>\n",
              "      <td>-3.3220</td>\n",
              "      <td>1.8800</td>\n",
              "      <td>-1.3250</td>\n",
              "      <td>-5.8890</td>\n",
              "      <td>-9.403</td>\n",
              "      <td>...</td>\n",
              "      <td>-4.765</td>\n",
              "      <td>-9.769</td>\n",
              "      <td>-5.790</td>\n",
              "      <td>-9.917</td>\n",
              "      <td>-5.745</td>\n",
              "      <td>-2.357</td>\n",
              "      <td>-9.119</td>\n",
              "      <td>-4.598</td>\n",
              "      <td>-8.776</td>\n",
              "      <td>-7.798</td>\n",
              "      <td>-4.162</td>\n",
              "      <td>-6.151</td>\n",
              "      <td>-5.740</td>\n",
              "      <td>-6.870</td>\n",
              "      <td>-9.100</td>\n",
              "      <td>-3.336</td>\n",
              "      <td>-6.642</td>\n",
              "      <td>-2.275</td>\n",
              "      <td>-3.472</td>\n",
              "      <td>-6.267</td>\n",
              "      <td>-6.398</td>\n",
              "      <td>-8.630</td>\n",
              "      <td>-8.149</td>\n",
              "      <td>-6.290</td>\n",
              "      <td>-8.097</td>\n",
              "      <td>-8.733</td>\n",
              "      <td>-2.378</td>\n",
              "      <td>-8.448</td>\n",
              "      <td>-4.455</td>\n",
              "      <td>-5.793</td>\n",
              "      <td>-3.700</td>\n",
              "      <td>2</td>\n",
              "      <td>True</td>\n",
              "      <td>0.0</td>\n",
              "      <td>1.0</td>\n",
              "      <td>1.0</td>\n",
              "      <td>0.0</td>\n",
              "      <td>0.0</td>\n",
              "      <td>1.0</td>\n",
              "      <td>0.0</td>\n",
              "    </tr>\n",
              "  </tbody>\n",
              "</table>\n",
              "<p>718 rows × 883 columns</p>\n",
              "</div>"
            ],
            "text/plain": [
              "                 id   composto      g0  ...  tempo_72  dose_D1  dose_D2\n",
              "16     id_002fb9c19  87d714366   8.738  ...       0.0      1.0      0.0\n",
              "76     id_00cf039a7  87d714366   4.546  ...       0.0      0.0      1.0\n",
              "119    id_01534c4ee  87d714366  10.000  ...       1.0      0.0      1.0\n",
              "209    id_0236e3425  87d714366   3.612  ...       1.0      1.0      0.0\n",
              "218    id_024a52260  87d714366   2.119  ...       0.0      0.0      1.0\n",
              "...             ...        ...     ...  ...       ...      ...      ...\n",
              "23680  id_fe8abffe0  87d714366   6.649  ...       1.0      1.0      0.0\n",
              "23727  id_ff1d43f96  87d714366   3.263  ...       0.0      0.0      1.0\n",
              "23776  id_ff9d0a022  87d714366   1.227  ...       0.0      0.0      1.0\n",
              "23791  id_ffd1fd119  87d714366   5.312  ...       1.0      0.0      1.0\n",
              "23802  id_fff3976bd  87d714366   3.289  ...       0.0      1.0      0.0\n",
              "\n",
              "[718 rows x 883 columns]"
            ]
          },
          "metadata": {
            "tags": []
          },
          "execution_count": 48
        }
      ]
    }
  ]
}