diff --git a/buildroot/share/PlatformIO/variants/MARLIN_F103Zx/PinNamesVar.h b/buildroot/share/PlatformIO/variants/MARLIN_F103Zx/PinNamesVar.h
index d9076b4dfb59c..e2e7040857888 100644
--- a/buildroot/share/PlatformIO/variants/MARLIN_F103Zx/PinNamesVar.h
+++ b/buildroot/share/PlatformIO/variants/MARLIN_F103Zx/PinNamesVar.h
@@ -1,5 +1,6 @@
 /* SYS_WKUP */
-#ifdef PWR_WAKEUP_PIN1
+#if defined(PWR_WAKEUP_PIN1) && defined(HAL_PWR_MODULE_ENABLED) && !defined(HAL_PWR_MODULE_ONLY)
+  #error "PA0 is used by thermal sensor, disable low power wake with -DHAL_PWR_MODULE_ONLY"
   SYS_WKUP1 = PA_0,
 #endif
 #ifdef PWR_WAKEUP_PIN2