diff --git a/Marlin/src/pins/esp32/pins_E4D.h b/Marlin/src/pins/esp32/pins_E4D.h
index 15b697a85b2c9..06e46e3c4c084 100644
--- a/Marlin/src/pins/esp32/pins_E4D.h
+++ b/Marlin/src/pins/esp32/pins_E4D.h
@@ -30,9 +30,7 @@
 
 #include "env_validate.h"
 
-#if EXTRUDERS > 1 || E_STEPPERS > 1
-  #error "E4d@box only supports 1 E stepper."
-#elif HAS_MULTI_HOTEND
+#if HAS_MULTI_HOTEND || E_STEPPERS > 1
   #error "E4d@box only supports 1 hotend / E stepper."
 #endif
 
diff --git a/Marlin/src/pins/esp32/pins_FYSETC_E4.h b/Marlin/src/pins/esp32/pins_FYSETC_E4.h
index 7dc59979c8f11..4bcffb545ee0d 100644
--- a/Marlin/src/pins/esp32/pins_FYSETC_E4.h
+++ b/Marlin/src/pins/esp32/pins_FYSETC_E4.h
@@ -30,9 +30,7 @@
 
 #include "env_validate.h"
 
-#if EXTRUDERS > 1 || E_STEPPERS > 1
-  #error "FYSETC E4 only supports 1 E stepper."
-#elif HAS_MULTI_HOTEND
+#if HAS_MULTI_HOTEND || E_STEPPERS > 1
   #error "FYSETC E4 only supports 1 hotend / E stepper."
 #endif
 
diff --git a/Marlin/src/pins/esp32/pins_MRR_ESPA.h b/Marlin/src/pins/esp32/pins_MRR_ESPA.h
index e9e3db575896e..ba5f6cbe35fab 100644
--- a/Marlin/src/pins/esp32/pins_MRR_ESPA.h
+++ b/Marlin/src/pins/esp32/pins_MRR_ESPA.h
@@ -30,9 +30,7 @@
 
 #include "env_validate.h"
 
-#if EXTRUDERS > 1 || E_STEPPERS > 1
-  #error "MRR ESPA only supports 1 E stepper."
-#elif HAS_MULTI_HOTEND
+#if HAS_MULTI_HOTEND || E_STEPPERS > 1
   #error "MRR ESPA only supports 1 hotend / E stepper."
 #endif
 
diff --git a/Marlin/src/pins/esp32/pins_PANDA_M4.h b/Marlin/src/pins/esp32/pins_PANDA_M4.h
index 5e2e72af05dfd..c619be43a5f83 100644
--- a/Marlin/src/pins/esp32/pins_PANDA_M4.h
+++ b/Marlin/src/pins/esp32/pins_PANDA_M4.h
@@ -27,6 +27,10 @@
 
 #define BOARD_INFO_NAME "Panda_M4"
 
+#if HAS_MULTI_HOTEND || E_STEPPERS > 1
+  #error "PANDA M4 only supports 1 hotend / E stepper."
+#endif
+
 #include "pins_PANDA_common.h"
 
 //
diff --git a/Marlin/src/pins/esp32/pins_PANDA_ZHU.h b/Marlin/src/pins/esp32/pins_PANDA_ZHU.h
index 47500578976e4..f2a5f440f6743 100644
--- a/Marlin/src/pins/esp32/pins_PANDA_ZHU.h
+++ b/Marlin/src/pins/esp32/pins_PANDA_ZHU.h
@@ -27,6 +27,12 @@
 
 #define BOARD_INFO_NAME "Panda_ZHU"
 
+#if E_STEPPERS > 5
+  #error "PANDA ZHU supports up to 5 E steppers."
+#if HAS_MULTI_HOTEND
+  #error "PANDA ZHU only supports 1 hotend."
+#endif
+
 #include "pins_PANDA_common.h"
 
 //
diff --git a/Marlin/src/pins/mega/pins_GT2560_V3.h b/Marlin/src/pins/mega/pins_GT2560_V3.h
index b04962bbb3575..61f30fc7d4f4a 100644
--- a/Marlin/src/pins/mega/pins_GT2560_V3.h
+++ b/Marlin/src/pins/mega/pins_GT2560_V3.h
@@ -33,6 +33,10 @@
 #define ALLOW_MEGA1280
 #include "env_validate.h"
 
+#if HOTENDS > 3 || E_STEPPERS > 3
+  #error "GT2560 supports up to 3 hotends / E steppers."
+#endif
+
 #ifndef BOARD_INFO_NAME
   #define BOARD_INFO_NAME "GT2560 3.x"
 #endif
diff --git a/Marlin/src/pins/mega/pins_PICA.h b/Marlin/src/pins/mega/pins_PICA.h
index 0541e1af58bf8..8b2aeccbbfbf7 100644
--- a/Marlin/src/pins/mega/pins_PICA.h
+++ b/Marlin/src/pins/mega/pins_PICA.h
@@ -35,6 +35,12 @@
 
 #include "env_validate.h"
 
+#if E_STEPPERS > 2
+  #error "PICA supports up to 2 E steppers."
+#if HOTENDS > 4
+  #error "PICA supports up to 4 hotends."
+#endif
+
 #ifndef BOARD_INFO_NAME
   #define BOARD_INFO_NAME "PICA"
 #endif
diff --git a/Marlin/src/pins/stm32f4/pins_ARTILLERY_RUBY.h b/Marlin/src/pins/stm32f4/pins_ARTILLERY_RUBY.h
index 7b0206e2878f0..8510e8148259c 100644
--- a/Marlin/src/pins/stm32f4/pins_ARTILLERY_RUBY.h
+++ b/Marlin/src/pins/stm32f4/pins_ARTILLERY_RUBY.h
@@ -23,7 +23,7 @@
 
 #include "env_validate.h"
 
-#if HOTENDS > 1 || E_STEPPERS > 1
+#if HAS_MULTI_HOTEND || E_STEPPERS > 1
   #error "Artillery Ruby only supports 1 hotend / E stepper."
 #endif
 
diff --git a/Marlin/src/pins/stm32f4/pins_BTT_SKR_MINI_E3_V3_0_1.h b/Marlin/src/pins/stm32f4/pins_BTT_SKR_MINI_E3_V3_0_1.h
index ffddeff67c0f9..6f2de83b5142a 100644
--- a/Marlin/src/pins/stm32f4/pins_BTT_SKR_MINI_E3_V3_0_1.h
+++ b/Marlin/src/pins/stm32f4/pins_BTT_SKR_MINI_E3_V3_0_1.h
@@ -25,7 +25,7 @@
 
 #include "env_validate.h"
 
-#if HOTENDS > 1 || E_STEPPERS > 1
+#if HAS_MULTI_HOTEND || E_STEPPERS > 1
   #error "BTT SKR Mini E3 V3.0.1 supports up to 1 hotend / E stepper."
 #endif
 
diff --git a/Marlin/src/pins/stm32f4/pins_TH3D_EZBOARD_V2.h b/Marlin/src/pins/stm32f4/pins_TH3D_EZBOARD_V2.h
index 448c54f1b3e41..b74db89f3a0c9 100644
--- a/Marlin/src/pins/stm32f4/pins_TH3D_EZBOARD_V2.h
+++ b/Marlin/src/pins/stm32f4/pins_TH3D_EZBOARD_V2.h
@@ -24,7 +24,7 @@
 #define ALLOW_STM32DUINO
 #include "env_validate.h"
 
-#if HOTENDS > 1 || E_STEPPERS > 1
+#if HAS_MULTI_HOTEND || E_STEPPERS > 1
   #error "TH3D EZBoard only supports 1 hotend / E stepper."
 #endif