diff --git a/targets/TARGET_STM/TARGET_STM32F0/device.h b/targets/TARGET_STM/TARGET_STM32F0/device.h
index b6131682750..93edfb5237a 100644
--- a/targets/TARGET_STM/TARGET_STM32F0/device.h
+++ b/targets/TARGET_STM/TARGET_STM32F0/device.h
@@ -36,5 +36,7 @@
 #define DEVICE_ID_LENGTH       24
 
 #include "objects.h"
+/*  WORKAROUND waiting for mbed-os issue 4408 to be addressed */
+#include "stm32f0xx_ll_usart.h"
 
 #endif
diff --git a/targets/TARGET_STM/TARGET_STM32F1/device.h b/targets/TARGET_STM/TARGET_STM32F1/device.h
index b6131682750..645517f59cc 100644
--- a/targets/TARGET_STM/TARGET_STM32F1/device.h
+++ b/targets/TARGET_STM/TARGET_STM32F1/device.h
@@ -36,5 +36,7 @@
 #define DEVICE_ID_LENGTH       24
 
 #include "objects.h"
+/*  WORKAROUND waiting for mbed-os issue 4408 to be addressed */
+#include "stm32f1xx_ll_usart.h"
 
 #endif
diff --git a/targets/TARGET_STM/TARGET_STM32F2/device.h b/targets/TARGET_STM/TARGET_STM32F2/device.h
index 8037b590d69..a60fa2abae0 100644
--- a/targets/TARGET_STM/TARGET_STM32F2/device.h
+++ b/targets/TARGET_STM/TARGET_STM32F2/device.h
@@ -33,5 +33,7 @@
 #define DEVICE_ID_LENGTH       24
 
 #include "objects.h"
+/*  WORKAROUND waiting for mbed-os issue 4408 to be addressed */
+#include "stm32f2xx_ll_usart.h"
 
 #endif
diff --git a/targets/TARGET_STM/TARGET_STM32F3/device.h b/targets/TARGET_STM/TARGET_STM32F3/device.h
index b6131682750..df642ecaa54 100644
--- a/targets/TARGET_STM/TARGET_STM32F3/device.h
+++ b/targets/TARGET_STM/TARGET_STM32F3/device.h
@@ -36,5 +36,7 @@
 #define DEVICE_ID_LENGTH       24
 
 #include "objects.h"
+/*  WORKAROUND waiting for mbed-os issue 4408 to be addressed */
+#include "stm32f3xx_ll_usart.h"
 
 #endif
diff --git a/targets/TARGET_STM/TARGET_STM32F4/device.h b/targets/TARGET_STM/TARGET_STM32F4/device.h
index b6131682750..d06e96fbbd2 100644
--- a/targets/TARGET_STM/TARGET_STM32F4/device.h
+++ b/targets/TARGET_STM/TARGET_STM32F4/device.h
@@ -36,5 +36,7 @@
 #define DEVICE_ID_LENGTH       24
 
 #include "objects.h"
+/*  WORKAROUND waiting for mbed-os issue 4408 to be addressed */
+#include "stm32f4xx_ll_usart.h"
 
 #endif
diff --git a/targets/TARGET_STM/TARGET_STM32F7/device.h b/targets/TARGET_STM/TARGET_STM32F7/device.h
index b6131682750..eec6746ca32 100644
--- a/targets/TARGET_STM/TARGET_STM32F7/device.h
+++ b/targets/TARGET_STM/TARGET_STM32F7/device.h
@@ -36,5 +36,7 @@
 #define DEVICE_ID_LENGTH       24
 
 #include "objects.h"
+/*  WORKAROUND waiting for mbed-os issue 4408 to be addressed */
+#include "stm32f7xx_ll_usart.h"
 
 #endif
diff --git a/targets/TARGET_STM/TARGET_STM32L0/device.h b/targets/TARGET_STM/TARGET_STM32L0/device.h
index b6131682750..57871faa2a1 100644
--- a/targets/TARGET_STM/TARGET_STM32L0/device.h
+++ b/targets/TARGET_STM/TARGET_STM32L0/device.h
@@ -36,5 +36,7 @@
 #define DEVICE_ID_LENGTH       24
 
 #include "objects.h"
+/*  WORKAROUND waiting for mbed-os issue 4408 to be addressed */
+#include "stm32l0xx_ll_usart.h"
 
 #endif
diff --git a/targets/TARGET_STM/TARGET_STM32L1/device.h b/targets/TARGET_STM/TARGET_STM32L1/device.h
index b6131682750..31b00715e27 100644
--- a/targets/TARGET_STM/TARGET_STM32L1/device.h
+++ b/targets/TARGET_STM/TARGET_STM32L1/device.h
@@ -36,5 +36,7 @@
 #define DEVICE_ID_LENGTH       24
 
 #include "objects.h"
+/*  WORKAROUND waiting for mbed-os issue 4408 to be addressed */
+#include "stm32l1xx_ll_usart.h"
 
 #endif
diff --git a/targets/TARGET_STM/TARGET_STM32L4/device.h b/targets/TARGET_STM/TARGET_STM32L4/device.h
index b6131682750..bae9f605b82 100644
--- a/targets/TARGET_STM/TARGET_STM32L4/device.h
+++ b/targets/TARGET_STM/TARGET_STM32L4/device.h
@@ -36,5 +36,7 @@
 #define DEVICE_ID_LENGTH       24
 
 #include "objects.h"
+/*  WORKAROUND waiting for mbed-os issue 4408 to be addressed */
+#include "stm32l4xx_ll_usart.h"
 
 #endif
diff --git a/targets/TARGET_STM/serial_api.c b/targets/TARGET_STM/serial_api.c
index d245a58cf65..441d6114053 100644
--- a/targets/TARGET_STM/serial_api.c
+++ b/targets/TARGET_STM/serial_api.c
@@ -690,4 +690,105 @@ int8_t get_uart_index(UARTName uart_name)
     return -1;
 }
 
+/*  Function to protect deep sleep while a seral Tx is ongoing on not complete
+ *  yet. Returns 1 if there is at least 1 serial instance with ongoing ransfer
+ *  0 otherwise.
+ */
+int serial_IsTxOngoing(void) {
+    int TxOngoing = 0;
+
+#if defined(USART1_BASE)
+    if (LL_USART_IsEnabled(USART1) && !LL_USART_IsActiveFlag_TC(USART1)) {
+        TxOngoing |= 1;
+    }
+#endif
+
+#if defined(USART2_BASE)
+    if (LL_USART_IsEnabled(USART2) && !LL_USART_IsActiveFlag_TC(USART2)) {
+        TxOngoing |= 1;
+    }
+#endif
+
+#if defined(USART3_BASE)
+    if (LL_USART_IsEnabled(USART3) && !LL_USART_IsActiveFlag_TC(USART3)) {
+        TxOngoing |= 1;
+    }
+#endif
+
+#if defined(UART4_BASE)
+    if (LL_USART_IsEnabled(UART4) && !LL_USART_IsActiveFlag_TC(UART4)) {
+        TxOngoing |= 1;
+    }
+#endif
+
+#if defined(USART4_BASE)
+    if (LL_USART_IsEnabled(USART4) && !LL_USART_IsActiveFlag_TC(USART4)) {
+        TxOngoing |= 1;
+    }
+#endif
+
+#if defined(UART5_BASE)
+    if (LL_USART_IsEnabled(UART5) && !LL_USART_IsActiveFlag_TC(UART5)) {
+        TxOngoing |= 1;
+    }
+#endif
+
+#if defined(USART5_BASE)
+    if (LL_USART_IsEnabled(USART5) && !LL_USART_IsActiveFlag_TC(USART5)) {
+        TxOngoing |= 1;
+    }
+#endif
+
+#if defined(USART6_BASE)
+    if (LL_USART_IsEnabled(USART6) && !LL_USART_IsActiveFlag_TC(USART6)) {
+        TxOngoing |= 1;
+    }
+#endif
+
+#if defined(UART7_BASE)
+    if (LL_USART_IsEnabled(UART7) && !LL_USART_IsActiveFlag_TC(UART7)) {
+        TxOngoing |= 1;
+    }
+#endif
+
+#if defined(USART7_BASE)
+    if (LL_USART_IsEnabled(USART7) && !LL_USART_IsActiveFlag_TC(USART7)) {
+        TxOngoing |= 1;
+    }
+#endif
+
+#if defined(UART8_BASE)
+    if (LL_USART_IsEnabled(UART8) && !LL_USART_IsActiveFlag_TC(UART8)) {
+        TxOngoing |= 1;
+    }
+#endif
+
+#if defined(USART8_BASE)
+    if (LL_USART_IsEnabled(USART8) && !LL_USART_IsActiveFlag_TC(USART8)) {
+        TxOngoing |= 1;
+    }
+#endif
+
+#if defined(UART9_BASE)
+    if (LL_USART_IsEnabled(UART9) && !LL_USART_IsActiveFlag_TC(UART9)) {
+        TxOngoing |= 1;
+    }
+#endif
+
+#if defined(UART10_BASE)
+    if (LL_USART_IsEnabled(UART10) && !LL_USART_IsActiveFlag_TC(UART10)) {
+        TxOngoing |= 1;
+    }
+#endif
+
+#if defined(LPUART1_BASE)
+    if (LL_USART_IsEnabled(LPUART1) && !LL_USART_IsActiveFlag_TC(LPUART1)) {
+        TxOngoing |= 1;
+    }
+#endif
+
+    /*  If Tx is ongoing, then transfer is */
+    return TxOngoing;
+}
+
 #endif /* DEVICE_SERIAL */
diff --git a/targets/TARGET_STM/sleep.c b/targets/TARGET_STM/sleep.c
index 866a46aff81..53a75576355 100644
--- a/targets/TARGET_STM/sleep.c
+++ b/targets/TARGET_STM/sleep.c
@@ -157,8 +157,20 @@ void hal_sleep(void)
     core_util_critical_section_exit();
 }
 
+extern int serial_IsTxOngoing(void);
+
 void hal_deepsleep(void)
 {
+    /*  WORKAROUND:
+     *  MBED serial driver does not handle deepsleep lock
+     *  to prevent entering deepsleep until HW serial FIFO is empty.
+     *  This is tracked in mbed issue 4408.
+     *  For now, we're checking all Serial HW FIFO. If any transfer is ongoing
+     *  we're not entering deep sleep and returning immediately. */
+    if(serial_IsTxOngoing()) {
+        return;
+    }
+
     // Disable IRQs
     core_util_critical_section_enter();