From 8c728f5992e871afb74a80e4d6f06cc7def3c173 Mon Sep 17 00:00:00 2001 From: James Stevenson Date: Sun, 21 Jan 2024 14:36:20 -0500 Subject: [PATCH] refactor: major edits to VRS mapping and supporting methods (#7) --- README.md | 20 +- TODO.md | 24 + pyproject.toml | 5 +- src/dcd_mapping/cli.py | 2 +- src/dcd_mapping/lookup.py | 42 +- src/dcd_mapping/main.py | 12 +- src/dcd_mapping/schemas.py | 17 +- src/dcd_mapping/vrs_map.py | 290 +- tests/conftest.py | 32 +- .../urn:mavedb:00000018-a-1_scores.csv | 624 +++ .../urn:mavedb:00000024-a-1_scores.csv | 2020 ++++++++++ .../urn:mavedb:00000041-a-1_scores.csv | 3507 +++++++++++++++++ tests/unit/test_vrs_map.py | 110 +- 13 files changed, 6571 insertions(+), 134 deletions(-) create mode 100644 TODO.md create mode 100644 tests/fixtures/urn:mavedb:00000018-a-1_scores.csv create mode 100644 tests/fixtures/urn:mavedb:00000024-a-1_scores.csv create mode 100644 tests/fixtures/urn:mavedb:00000041-a-1_scores.csv diff --git a/README.md b/README.md index e75d031..e5be55c 100644 --- a/README.md +++ b/README.md @@ -1,6 +1,10 @@ # dcd-mapping -## Usage +## Results + +Mapped MaveDB Scoresets can be downloaded here: https://mavedb-mapping.s3.us-east-2.amazonaws.com/mappings.tar.gz + +## Tool usage Use the `dcd-map` command with a scoreset URN, eg @@ -10,6 +14,16 @@ $ dcd-map urn:mavedb:00000083-c-1 Output is saved in the format `_mapping_results.json` in the directory specified by the environment variable `MAVEDB_STORAGE_DIR`, or `~/.local/share/dcd-mapping` by default. +## Setup + +Following installation instructions for [CoolSeqTool](https://coolseqtool.readthedocs.io/en/0.4.0-dev1/install.html) and [Gene Normalizer](https://gene-normalizer.readthedocs.io/en/latest/install.html) should take care of the external data dependencies. + +Note that Gene Normalizer's `pg` dependency group must be installed to make use of the PostgreSQL-based backend: + +```shell +python3 -m pip install 'gene-normalizer[pg]' +``` + ## Development Clone the repo @@ -38,6 +52,4 @@ Add pre-commit hooks pre-commit install ``` -## Data - -Mapped MaveDB Scoresets can be downloaded here: https://mavedb-mapping.s3.us-east-2.amazonaws.com/mappings.tar.gz +When debugging, use flags `-c` and `-d` to enable caching of BLAT alignment and debug logging, respectively. diff --git a/TODO.md b/TODO.md new file mode 100644 index 0000000..8f18152 --- /dev/null +++ b/TODO.md @@ -0,0 +1,24 @@ +# Remaining TODO + +General: +* notes scattered in comments and docstrings (sorry!) +* Docker-ification. More or less needs to start from scratch (there should be existing images for SeqRepo and UTA, not sure how up-to-date they are). +* Add extra stuff that appears in mapping JSON objects. +* Currently using VRS 2.0a-based libraries. For lifting back to VRS 1.3, some basic post-processing should be fine (annoying but shouldn't be too trivial) +* Without access to a production DynamoDB instance, Gene Normalizer will be quickest and easiest to set up via a PostgreSQL data backend. That, however, requires an extra dependency group (noted in README). We might want to make a `pg` dependency group here or just include it in core dependencies. +* On that note, I've only done minimal testing of how possible it would be to drop the gene normalizer dependency entirely, but it'd be nice to get there. +* Some of the singleton/factory stuff might be cleaner as `global`s + +Alignment: +* Pretty sure this is mostly done. Haven't tested exhaustively, though. +* Need to sufficiently mock/patch things in tests + +Transcript selection: +* IndexError in calculating offset on lots of new (2023) scoresets. +* Tests will need some extensive mocking (or cassettes?) for reliance on UTA and other external dependencies + +VRS mapping: +* In general, this stuff is still pretty rough. Tests aren't passing yet. +* Finish double-checking the SeqRepo storage workaround +* A fair amount of small questions about conditions written to handle specific scoresets/edge cases +* More testing. Can be ready for CI by manually patching the SequenceStore class (or using SeqRepoRESTDataProxy and cassettes). diff --git a/pyproject.toml b/pyproject.toml index 79fe657..04f4c0a 100644 --- a/pyproject.toml +++ b/pyproject.toml @@ -80,8 +80,9 @@ src = ["src"] # pydocstyle (D) # pep8-naming (N) # isort (I) -select = ["E", "W", "F", "ANN", "D", "N", "I"] -fixable = ["I", "F401"] +select = ["E", "W", "F", "ANN", "D", "N", "I", "T201", "T100"] +fixable = ["I", "F401", "T201", "T100"] +include = ["pyproject.toml", "tests/**/*.py", "src/**/*.py"] # ANN101 - missing-type-self # ANN003 - missing-type-kwargs diff --git a/src/dcd_mapping/cli.py b/src/dcd_mapping/cli.py index 77fe2fb..e65c535 100644 --- a/src/dcd_mapping/cli.py +++ b/src/dcd_mapping/cli.py @@ -41,7 +41,7 @@ def cli(urn: str, debug: bool, cache_align: bool) -> None: """ # noqa: D301 logging.basicConfig( filename="dcd-mapping.log", - format="%(asctime)s %(levelname)s:%(message)s", + format="%(asctime)s %(levelname)s:%(name)s:%(message)s", level=logging.INFO, force=True, ) diff --git a/src/dcd_mapping/lookup.py b/src/dcd_mapping/lookup.py index 5e8f873..eccdba0 100644 --- a/src/dcd_mapping/lookup.py +++ b/src/dcd_mapping/lookup.py @@ -12,6 +12,7 @@ from cool_seq_tool.schemas import TranscriptPriority from ga4gh.core._internal.models import Extension, Gene from ga4gh.vrs._internal.models import Allele, SequenceLocation +from ga4gh.vrs.dataproxy import SeqRepoDataProxy from ga4gh.vrs.extras.translator import AlleleTranslator from gene.database import create_db from gene.query import QueryHandler @@ -23,7 +24,6 @@ "CoolSeqToolBuilder", "get_seqrepo", "GeneNormalizerBuilder", - "VrsTranslatorBuilder", "get_protein_accession", "get_transcripts", "get_gene_symbol", @@ -33,7 +33,7 @@ "get_chromosome_identifier_from_vrs_id", "get_sequence", "store_sequence", - "hgvs_to_vrs", + "translate_hgvs_to_vrs", "get_mane_transcripts", "get_uniprot_sequence", ] @@ -76,17 +76,20 @@ def __new__(cls) -> QueryHandler: return cls.instance -class VrsTranslatorBuilder: - """Singleton constructor for VRS-Python translator instance.""" +class TranslatorBuilder: + """Singleton constructor for VRS Translator instance.""" - def __new__(cls) -> AlleleTranslator: - """Provide VRS-Python translator. Construct if unavailable. + def __new__(cls, data_proxy: SeqRepoDataProxy) -> AlleleTranslator: + """Provide translator instance. Constructs it if unavailable. Use a new + ``data_proxy`` instance that contains a given score row's sequence/ID. - :return: singleton instances of Translator + :return: singleton instance of ``AlleleTranslator`` """ if not hasattr(cls, "instance"): - cst = CoolSeqToolBuilder() - cls.instance = AlleleTranslator(cst.seqrepo_access, normalize=False) + tr = AlleleTranslator(data_proxy, normalize=False) + cls.instance = tr + else: + cls.instance.data_proxy = data_proxy return cls.instance @@ -280,15 +283,17 @@ def get_gene_location(metadata: ScoresetMetadata) -> Optional[GeneLocation]: def get_chromosome_identifier(chromosome: str) -> str: """Get latest NC_ accession identifier given a chromosome name. - :param chromosome: prefix-free chromosome name, e.g. ``"8"``, ``"X"`` + :param chromosome: chromosome name, e.g. ``"8"``, ``"X"`` :return: latest ID if available :raise KeyError: if unable to retrieve identifier """ + if not chromosome.startswith("chr"): + chromosome = f"chr{chromosome}" sr = CoolSeqToolBuilder().seqrepo_access acs = [] for assembly in ["GRCh38", "GRCh37"]: tmp_acs, _ = sr.translate_identifier( - f"{assembly}:chr{chromosome}", target_namespaces="refseq" + f"{assembly}:{chromosome}", target_namespaces="refseq" ) for ac in tmp_acs: acs.append(ac.split("refseq:")[-1]) @@ -378,18 +383,15 @@ def store_sequence(sequence: str, names: List[Dict]) -> None: # -------------------------------- VRS-Python -------------------------------- # -def hgvs_to_vrs(hgvs: str, alias_map: Dict) -> Allele: +def translate_hgvs_to_vrs(hgvs: str, data_proxy: SeqRepoDataProxy) -> Allele: """Convert HGVS variation description to VRS object. - # TODO incorporate alias map - :param hgvs: MAVE-HGVS variation string - :param alias_map: lookup for custom sequence IDs + :param data_proxy: :return: Corresponding VRS allele as a Pydantic class """ - tr = VrsTranslatorBuilder() - vrs_allele = tr.translate_from(hgvs, "hgvs") - allele = Allele(**vrs_allele) + tr = TranslatorBuilder(data_proxy) + allele = tr.translate_from(hgvs, "hgvs") if ( not isinstance(allele.location, SequenceLocation) @@ -398,6 +400,10 @@ def hgvs_to_vrs(hgvs: str, alias_map: Dict) -> Allele: ): raise ValueError + # TODO temporary, remove + if not isinstance(allele, Allele): + raise NotImplementedError + return allele diff --git a/src/dcd_mapping/main.py b/src/dcd_mapping/main.py index a4e1ac8..85d73f1 100644 --- a/src/dcd_mapping/main.py +++ b/src/dcd_mapping/main.py @@ -1,6 +1,7 @@ """Provide core MaveDB mapping methods.""" import json import logging +from pathlib import Path from typing import List import click @@ -21,20 +22,23 @@ def _save_results( metadata: ScoresetMetadata, mapping_results: VrsMappingResult -) -> None: +) -> Path: """Save results to file. Todo: ---- - * Embed in original metadata JSON + * add ``mapped_reference_sequence`` and ``computed_referense_sequence`` properties + * Embed within original metadata JSON * Option to save as VRS 1.x :param metadata: scoreset metadata :param mapping results: mapped objects + :return: path to saved file """ outfile = LOCAL_STORE_PATH / f"{metadata.urn}_mapping_results.json" with open(outfile, "w") as f: - json.dump(mapping_results.model_dump_json(indent=2), f) + json.dump(mapping_results.model_dump(exclude_none=True), f, indent=2) + return outfile async def map_scoreset( @@ -65,7 +69,7 @@ async def map_scoreset( return None try: - vrs_results = vrs_map(metadata, alignment_result, transcript, records) + vrs_results = vrs_map(metadata, alignment_result, transcript, records, silent) except VrsMapError: _logger.error(f"VRS mapping failed for scoreset {metadata.urn}") return None diff --git a/src/dcd_mapping/schemas.py b/src/dcd_mapping/schemas.py index 7958213..d9fba2b 100644 --- a/src/dcd_mapping/schemas.py +++ b/src/dcd_mapping/schemas.py @@ -4,7 +4,7 @@ from cool_seq_tool.schemas import Strand, TranscriptPriority from ga4gh.vrs._internal.models import Allele, Haplotype -from pydantic import BaseModel, StrictBool, StrictInt +from pydantic import BaseModel, StrictBool, StrictFloat, StrictInt, StrictStr class TargetSequenceType(StrEnum): @@ -125,13 +125,14 @@ class TxSelectResult(BaseModel): class VrsMapping(BaseModel): - """Define pre-post mapping pair structure for VRS-structured variations. - - Probably need to add score and accession to make json writing easier - """ - - pre_mapping: Union[Allele, Haplotype] - mapped: Union[Allele, Haplotype] + """Define pre-post mapping pair structure for VRS-structured variations.""" + + mavedb_id: StrictStr + pre_mapped: Union[Allele, Haplotype] + post_mapped: Union[Allele, Haplotype] + mapped_transcript: Optional[TranscriptDescription] = None + score: StrictFloat + # relation: Literal["SO:is_homologous_to"] = "SO:is_homologous_to" class VrsMappingResult(BaseModel): diff --git a/src/dcd_mapping/vrs_map.py b/src/dcd_mapping/vrs_map.py index c2feebf..4408343 100644 --- a/src/dcd_mapping/vrs_map.py +++ b/src/dcd_mapping/vrs_map.py @@ -1,4 +1,13 @@ -"""Map transcripts to VRS objects.""" +"""Map transcripts to VRS objects. + +Outstanding tasks/questions: +--------------------------- +* Make sure typed digests vs full IDs vs plain digests are all being used correctly +* What is ``vrs_ref_allele_seq`` in output? +* Add basic transcript description where available +* Add HGVS expressions to alleles where available +""" +import functools import logging from typing import Dict, List, Optional, Union @@ -13,7 +22,11 @@ from ga4gh.vrs.dataproxy import SeqRepoDataProxy from ga4gh.vrs.normalize import normalize -from dcd_mapping.lookup import get_chromosome_identifier, get_seqrepo, hgvs_to_vrs +from dcd_mapping.lookup import ( + get_chromosome_identifier, + get_seqrepo, + translate_hgvs_to_vrs, +) from dcd_mapping.schemas import ( AlignmentResult, ScoreRow, @@ -40,23 +53,147 @@ class SequenceStore(SeqRepoDataProxy): Outstanding questions: --------------------- - * not totally sure what internal sequence storage looks like yet + * not 100% that this is working correctly + * move this over to `lookup.py` and make a singleton factory for it """ - # key sequence digest to sequence + def __init__(self) -> None: + """Initialize storage instance.""" + super().__init__(sr=get_seqrepo().sr) + + # key sequence ID to sequence local_sequences: Dict[str, str] = {} + def _get_metadata(self, identifier: str) -> Dict: + """Fetch metadata for identifier. + + :param identifier: sequence ID + :return: various supporting metadata for object. For locally-injected sequences, + this is basically empty, but we need it to not raise any KeyErrors. + """ + if identifier in self.local_sequences: + return {"length": len(self.local_sequences[identifier]), "aliases": []} + else: + return super()._get_metadata(identifier) + + @functools.lru_cache() + def get_sequence( + self, identifier: str, start: Optional[int] = None, end: Optional[int] = None + ) -> str: # type: ignore + """Get sequence given an ID + + :param identifier: Sequence ID + :param start: optional starting slice + :param end: optional ending slice + :return: sequence as raw text + """ + if identifier in self.local_sequences: + if start is None and end is None: + return self.local_sequences[identifier] + elif start is None: + return self.local_sequences[identifier][:end] + else: + return self.local_sequences[identifier][:start] + else: + return super().get_sequence(identifier, start, end) # type: ignore + def _get_sequence_id(sequence: str) -> str: """Make GA4GH sequence identifier :param sequence: raw string sequence - :return: sequence identifier with digest (starting with ``"ga4gh:SQ."``) + :return: sequence type/digest """ - sequence_id = f"ga4gh:SQ.{sha512t24u(sequence).encode('ascii')}" + sequence_id = f"ga4gh:SQ.{sha512t24u(sequence.encode('ascii'))}" return sequence_id +def _dna_to_protein_sequence(sequence: str) -> str: + """Translate sequence to protein, if necessary + + Outstanding questions: + --------------------- + * Is there a better way to check for whether it's already at protein? Can't + we just rely on descriptions from the scoreset metadata? + + :param sequence: string of single letter nucleobase/amino acid codes + :return: string of single letter amino acid codes + """ + if len(set(str(sequence))) > 4: + formatted_sequence = sequence + else: + formatted_sequence = str(Seq(sequence).translate(table="1", stop_symbol="")) + return formatted_sequence + + +def _map_protein_coding_pro( + row: ScoreRow, + score: float, + sequence_store: SequenceStore, + align_result: AlignmentResult, + sequence: str, + sequence_id: str, + transcript: TxSelectResult, +) -> Optional[VrsMapping]: + """Construct VRS object mapping for ``hgvs_pro`` variant column entry + + These arguments are a little lazy and could be pruned down later + + :param row: + :param score: + :param sequence_store: + :param align_result: + :param sequence: + :param sequence_id: + :param transcript: + :return: VRS mapping object if mapping succeeds + """ + if row.hgvs_pro in {"_wt", "_sy"}: + _logger.warning( + f"Can't process Enrich2-style variant syntax {row.hgvs_nt} for {row.accession}" + ) + return None + if row.hgvs_pro.startswith("NP"): + vrs_variation = translate_hgvs_to_vrs(row.hgvs_pro, sequence_store) + mapping = VrsMapping( + mavedb_id=row.accession, + pre_mapped=vrs_variation, + post_mapped=vrs_variation, + score=score, + ) + else: + # TODO there's a conditional branch here based on whether the NP accession + # starts with "N" -- not clear to me whether it's necessary? + layer = AnnotationLayer.PROTEIN + hgvs_strings = _create_hgvs_strings(align_result, row.hgvs_pro, layer) + mapping = VrsMapping( + mavedb_id=row.accession, + score=score, + pre_mapped=_get_variation( + hgvs_strings, + layer, + sequence_id, + sequence, + align_result, + True, + ), + post_mapped=_get_variation( + hgvs_strings, + layer, + sequence_id, + sequence, + align_result, + False, + transcript.start, + ), + ) + return mapping + + +def _get_score(raw_score: str) -> float: + raise NotImplementedError + + def _map_protein_coding( metadata: ScoresetMetadata, records: List[ScoreRow], @@ -70,97 +207,65 @@ def _map_protein_coding( :param align_results: """ variations = VrsMappingResult(variations=[]) - sequence_id = _get_sequence_id(metadata.target_sequence) + sequence = _dna_to_protein_sequence(metadata.target_sequence) - # TODO get some clarification on this stuff - if len(set(str(metadata.target_sequence))) > 4: - formatted_sequence = str(metadata.target_sequence) - else: - formatted_sequence = str( - Seq(metadata.target_sequence).translate(table="1") - ).replace("*", "") - sequence_id = _get_sequence_id(formatted_sequence) - sequence_store = SequenceStore(sr=get_seqrepo().sr) - sequence_store.local_sequences[sequence_id] = formatted_sequence + sequence_id = _get_sequence_id(sequence) + sequence_store = SequenceStore() + sequence_store.local_sequences[sequence_id] = sequence for row in records: - if len(row.hgvs_pro) == 3: # TODO figure out why? + try: + score = float(row.score) + except ValueError: _logger.warning( - f"Skipping HGVS protein variation string '{row.hgvs_pro}' for {metadata.urn}" + "Unable to parse float value of score %s in %s", + row.score, + row.accession, ) continue - if row.hgvs_pro in {"_wt", "_sy"}: - _logger.warning( - f"Can't process Enrich2-style variant syntax {row.hgvs_nt} for {metadata.urn}" - ) - continue - if row.hgvs_pro.startswith("NP"): - variations.variations.append( - VrsMapping( - pre_mapping=hgvs_to_vrs(row.hgvs_pro, {}), # TODO handle alias dict - mapped=hgvs_to_vrs(row.hgvs_pro, {}), - ) - ) + + # hgvs_pro + hgvs_pro_mappings = _map_protein_coding_pro( + row, + score, + sequence_store, + align_result, + sequence, + sequence_id, + transcript, + ) + if hgvs_pro_mappings: + variations.variations.append(hgvs_pro_mappings) + + if row.hgvs_nt == "NA": + continue # TODO is it correct to be skipping this? can we project down? + if "97" in metadata.urn: + _logger.warning(f"Skipping hgvs_nt for {metadata.urn}") + continue # TODO more information about this else: - # TODO there's a branching here based on whether the NP accession starts with "N" - # not clear to me if it's necessary? - layer = AnnotationLayer.PROTEIN - hgvs_strings = _create_hgvs_strings(align_result, row.hgvs_pro, layer) + layer = AnnotationLayer.GENOMIC + hgvs_strings = _create_hgvs_strings(align_result, row.hgvs_nt, layer) variations.variations.append( VrsMapping( - pre_mapping=_get_haplotype_allele( + mavedb_id=row.accession, + score=score, + pre_mapped=_get_variation( hgvs_strings, layer, sequence_id, - formatted_sequence, + sequence, align_result, True, ), - mapped=_get_haplotype_allele( + post_mapped=_get_variation( hgvs_strings, layer, sequence_id, - formatted_sequence, + sequence, align_result, False, - transcript.start, ), ) ) - - # technically no need to do a second loop through records, but this lets us - # keep control flow distinct for pro and nt variant strings - layer = AnnotationLayer.GENOMIC - for row in records: - # try NT variation - if "97" in metadata.urn: - _logger.warning(f"Skipping hgvs_nt for {metadata.urn}") - continue # TODO more information about this - elif row.hgvs_nt in {"_wt", "_sy"}: - _logger.warning( - f"Can't process Enrich2-style variant syntax {row.hgvs_nt} for {metadata.urn}" - ) - continue - hgvs_strings = _create_hgvs_strings(align_result, row.hgvs_nt, layer) - variations.variations.append( - VrsMapping( - pre_mapping=_get_haplotype_allele( - hgvs_strings, - layer, - sequence_id, - formatted_sequence, - align_result, - True, - ), - mapped=_get_haplotype_allele( - hgvs_strings, - layer, - sequence_id, - formatted_sequence, - align_result, - False, - ), - ) - ) return variations @@ -172,7 +277,8 @@ def _create_hgvs_strings( descr_list = list(set(raw_description[1:-1].split(";"))) else: descr_list = [raw_description] - hgvs_strings = [f"{chrom_ac}:{layer.value}.{d}" for d in descr_list] + hgvs_strings = [f"{chrom_ac}:{d}" for d in descr_list] + # hgvs_strings = [f"{chrom_ac}:{layer.value}.{d}" for d in descr_list] return hgvs_strings @@ -190,7 +296,7 @@ def _get_allele_sequence(allele: Allele) -> str: return selection -def _get_haplotype_allele( +def _get_variation( hgvs_strings: List[str], layer: AnnotationLayer, sequence_id: str, @@ -213,7 +319,7 @@ def _get_haplotype_allele( :param hgvs_strings: :param layer: annotation layer - :param sequence_id: target sequence digest eg ``"ga4gh:SQ.SQ.jUOcLPDjSqWFEo9kSOG8ITe1dr9QK3h6" + :param sequence_id: target sequence digest eg ``"ga4gh:SQ.SQ.jUOcLPDjSqWFEo9kSOG8ITe1dr9QK3h6"`` :param sequence: target sequence :param alignment: :param pre_map: if True, return object for pre mapping stage. Otherwise return for @@ -221,11 +327,13 @@ def _get_haplotype_allele( :param offset: :return: """ + if sequence_id.startswith("ga4gh:"): + sequence_id = sequence_id[6:] alleles = [] - sequence_store = SequenceStore(sr=get_seqrepo().sr) + sequence_store = SequenceStore() sequence_store.local_sequences[sequence_id] = sequence for hgvs_string in hgvs_strings: - allele = hgvs_to_vrs(hgvs_string, {}) # TODO add alias map? + allele = translate_hgvs_to_vrs(hgvs_string, sequence_store) if "dup" in hgvs_string: allele.state.sequence = 2 * _get_allele_sequence(allele) # type: ignore if pre_map: @@ -267,7 +375,7 @@ def _get_haplotype_allele( allele.location.end = allele.location.start + diff2 # type: ignore allele.state.sequence = str( Seq(str(allele.state.sequence)).reverse_complement() - ) # type: ignore + ) if allele.state.sequence == "N" and layer != AnnotationLayer.PROTEIN: allele.state.sequence = _get_allele_sequence(allele) # type: ignore allele = normalize(allele, data_proxy=sequence_store) @@ -301,10 +409,19 @@ def _map_regulatory_noncoding( f"Can't process Enrich2-style variant syntax {row.hgvs_nt} for {metadata.urn}" ) continue + try: + score = float(row.score) + except ValueError: + _logger.warning( + "Unable to parse float value of score %s in %s", + row.score, + row.accession, + ) + continue hgvs_strings = _create_hgvs_strings( align_result, row.hgvs_nt[2:], AnnotationLayer.GENOMIC ) - pre_map_allele = _get_haplotype_allele( + pre_map_allele = _get_variation( hgvs_strings, AnnotationLayer.GENOMIC, sequence_id, @@ -313,7 +430,7 @@ def _map_regulatory_noncoding( pre_map=True, offset=0, ) - post_map_allele = _get_haplotype_allele( + post_map_allele = _get_variation( hgvs_strings, AnnotationLayer.GENOMIC, sequence_id, @@ -329,7 +446,12 @@ def _map_regulatory_noncoding( # not totally sure how to handle this raise NotImplementedError variations.variations.append( - VrsMapping(pre_mapping=pre_map_allele, mapped=post_map_allele) + VrsMapping( + pre_mapped=pre_map_allele, + post_mapped=post_map_allele, + mavedb_id=row.accession, + score=score, + ) ) return variations diff --git a/tests/conftest.py b/tests/conftest.py index 4e330a2..92713db 100644 --- a/tests/conftest.py +++ b/tests/conftest.py @@ -1,18 +1,30 @@ """Provide shared testing utilities.""" import json +import os from pathlib import Path import pytest from dcd_mapping.schemas import AlignmentResult, ScoresetMetadata, TxSelectResult +FIXTURE_DATA_DIR = Path(__file__).parents[0].resolve() / "fixtures" + + +def pytest_sessionstart(session) -> None: + """Initialize testing environment.""" + os.environ["MAVEDB_STORAGE_DIR"] = str(FIXTURE_DATA_DIR.absolute()) + + +@pytest.fixture(scope="session") +def fixture_data_dir(): + """Provide test data directory.""" + return FIXTURE_DATA_DIR + @pytest.fixture(scope="module") -def scoreset_metadata_fixture(): +def scoreset_metadata_fixture(fixture_data_dir: Path): """Provide scoreset metadata fixtures.""" - fixture_file = ( - Path(__file__).parents[0].resolve() / "fixtures" / "scoreset_metadata.json" - ) + fixture_file = fixture_data_dir / "scoreset_metadata.json" with open(fixture_file, "r") as f: data = json.load(f) results = {} @@ -23,11 +35,9 @@ def scoreset_metadata_fixture(): @pytest.fixture(scope="session") -def align_result_fixture(): +def align_result_fixture(fixture_data_dir: Path): """Provide fixtures for alignment results.""" - fixture_file = ( - Path(__file__).parents[0].resolve() / "fixtures" / "align_result.json" - ) + fixture_file = fixture_data_dir / "align_result.json" with open(fixture_file, "r") as f: data = json.load(f) results = {} @@ -38,11 +48,9 @@ def align_result_fixture(): @pytest.fixture(scope="session") -def transcript_results_fixture(): +def transcript_results_fixture(fixture_data_dir: Path): """Provide fixtures for transcript selection results.""" - fixture_file = ( - Path(__file__).parents[0].resolve() / "fixtures" / "transcript_result.json" - ) + fixture_file = fixture_data_dir / "transcript_result.json" with open(fixture_file, "r") as f: data = json.load(f) results = {} diff --git a/tests/fixtures/urn:mavedb:00000018-a-1_scores.csv b/tests/fixtures/urn:mavedb:00000018-a-1_scores.csv new file mode 100644 index 0000000..9cf15b6 --- /dev/null +++ b/tests/fixtures/urn:mavedb:00000018-a-1_scores.csv @@ -0,0 +1,624 @@ +accession,hgvs_nt,hgvs_splice,hgvs_pro,score,p-value,unique_tags,dna_sequences,rna_sequences +urn:mavedb:00000018-a-1#583,n.187T>G,NA,NA,-0.17,0.15164,142.0,593.0,1527.0 +urn:mavedb:00000018-a-1#1,n.1=,NA,NA,-0.51,0.0029,68.0,231.0,538.0 +urn:mavedb:00000018-a-1#2,n.3T>G,NA,NA,0.02,0.59763,1024.0,4445.0,13045.0 +urn:mavedb:00000018-a-1#3,n.31G>C,NA,NA,-0.03,0.48252,1125.0,5404.0,15058.0 +urn:mavedb:00000018-a-1#4,n.31G>T,NA,NA,-0.02,0.56915,1505.0,6947.0,18975.0 +urn:mavedb:00000018-a-1#5,n.32T>A,NA,NA,-0.1,0.00273,1851.0,7732.0,21468.0 +urn:mavedb:00000018-a-1#6,n.32T>C,NA,NA,0.12,0.0,4263.0,18769.0,58913.0 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+urn:mavedb:00000041-a-1#75,NA,NA,p.Tyr110Cys,1.289008364,8.949999999999999e-12,9.829999999999999e-23,-1.289008364 +urn:mavedb:00000041-a-1#1402,NA,NA,p.Asn125Cys,1.67129949,0.026495311,2.88e-05,-1.67129949 +urn:mavedb:00000041-a-1#76,NA,NA,p.Tyr110Asp,0.534206034,1.7899999999999998e-11,3.7699999999999997e-22,-0.534206034 +urn:mavedb:00000041-a-1#1823,NA,NA,p.Asp207Ser,0.967436905,2.68e-14,1.28e-27,-0.967436905 +urn:mavedb:00000041-a-1#82,NA,NA,p.Tyr69Pro,1.524289655,5.29e-08,1.7e-15,-1.524289655 +urn:mavedb:00000041-a-1#83,NA,NA,p.Tyr69Gln,1.036415476,0.234939091,4.43e-06,-1.036415476 +urn:mavedb:00000041-a-1#84,NA,NA,p.Tyr69Cys,0.798149998,5.4299999999999986e-36,5.53e-70,-0.798149998 +urn:mavedb:00000041-a-1#85,NA,NA,p.Tyr60Ter,1.659683368,6.25e-12,5.03e-23,-1.659683368 +urn:mavedb:00000041-a-1#2,NA,NA,p.Val15Gly,1.266378019,8.27e-13,1.0099999999999999e-24,-1.266378019 +urn:mavedb:00000041-a-1#1885,NA,NA,p.Val71Cys,0.026440378,1.54e-06,8.109999999999999e-13,-0.026440378 +urn:mavedb:00000041-a-1#95,NA,NA,p.Trp233Leu,1.059497329,1.19e-15,3.09e-30,-1.059497329 +urn:mavedb:00000041-a-1#1947,NA,NA,p.Tyr110Phe,0.355389263,6.8099999999999984e-18,1.3e-34,-0.355389263 +urn:mavedb:00000041-a-1#96,NA,NA,p.Trp233Ile,1.587240909,1.7100000000000002e-05,8.04e-11,-1.587240909 +urn:mavedb:00000041-a-1#97,NA,NA,p.Trp233His,0.694942325,1.98e-24,2.3699999999999996e-47,-0.694942325 +urn:mavedb:00000041-a-1#98,NA,NA,p.Trp233Gly,0.615332931,2.17e-19,1.6099999999999997e-37,-0.615332931 +urn:mavedb:00000041-a-1#1949,NA,NA,p.Tyr110His,0.109913418,0.360832551,0.0,-0.109913418 +urn:mavedb:00000041-a-1#113,NA,NA,p.Trp180Gln,1.4994386709999998,4.02e-12,2.15e-23,-1.4994386709999998 +urn:mavedb:00000041-a-1#114,NA,NA,p.Trp180Cys,1.427569219,0.002768448,3.579999999999999e-07,-1.427569219 +urn:mavedb:00000041-a-1#1950,NA,NA,p.Tyr91Val,0.278622758,5.89e-23,1.72e-44,-0.278622758 +urn:mavedb:00000041-a-1#115,NA,NA,p.Trp180Asp,1.563721743,3.720000000000001e-07,6.87e-14,-1.563721743 +urn:mavedb:00000041-a-1#116,NA,NA,p.Trp180Arg,1.4207837280000002,6.679999999999999e-09,3.32e-17,-1.4207837280000002 +urn:mavedb:00000041-a-1#117,NA,NA,p.Trp180Ala,1.561944574,1.2199999999999998e-07,8.28e-15,-1.561944574 +urn:mavedb:00000041-a-1#118,NA,NA,p.Trp162Val,1.567759553,5.21e-08,1.6399999999999998e-15,-1.567759553 +urn:mavedb:00000041-a-1#119,NA,NA,p.Trp162Tyr,1.457754479,1.19e-10,1.47e-20,-1.457754479 +urn:mavedb:00000041-a-1#120,NA,NA,p.Trp162Thr,1.494694869,1.84e-09,2.83e-18,-1.494694869 +urn:mavedb:00000041-a-1#121,NA,NA,p.Trp162Ter,1.665869112,2.7000000000000004e-06,2.7400000000000004e-12,-1.665869112 +urn:mavedb:00000041-a-1#122,NA,NA,p.Trp162Ser,1.5015166830000002,6.05e-13,5.550000000000001e-25,-1.5015166830000002 +urn:mavedb:00000041-a-1#123,NA,NA,p.Trp162Pro,1.589138535,3.97e-10,1.5e-19,-1.589138535 +urn:mavedb:00000041-a-1#124,NA,NA,p.Trp162Phe,1.3508405069999998,1.33e-10,1.82e-20,-1.3508405069999998 +urn:mavedb:00000041-a-1#125,NA,NA,p.Trp162Met,1.624827005,1.77e-08,2.12e-16,-1.624827005 +urn:mavedb:00000041-a-1#126,NA,NA,p.Trp162Lys,1.657221663,6.720000000000001e-05,9.54e-10,-1.657221663 +urn:mavedb:00000041-a-1#127,NA,NA,p.Trp162Leu,1.603250763,1.39e-11,2.38e-22,-1.603250763 +urn:mavedb:00000041-a-1#128,NA,NA,p.Trp162Ile,1.4780576319999998,5.02e-13,3.87e-25,-1.4780576319999998 +urn:mavedb:00000041-a-1#129,NA,NA,p.Trp162His,1.3239854359999998,2.84e-12,1.1e-23,-1.3239854359999998 +urn:mavedb:00000041-a-1#130,NA,NA,p.Trp162Gly,1.557781719,5.429999999999999e-07,1.3800000000000002e-13,-1.557781719 +urn:mavedb:00000041-a-1#150,NA,NA,p.Thr191Arg,1.203651848,2.57e-10,6.400000000000001e-20,-1.203651848 +urn:mavedb:00000041-a-1#151,NA,NA,p.Thr190Ser,1.212017455,5.53e-19,9.929999999999999e-37,-1.212017455 +urn:mavedb:00000041-a-1#152,NA,NA,p.Thr190Leu,0.707304996,2.95e-16,1.9999999999999997e-31,-0.707304996 +urn:mavedb:00000041-a-1#153,NA,NA,p.Thr190Glu,0.802598606,5.889999999999997e-53,3.22e-103,-0.802598606 +urn:mavedb:00000041-a-1#154,NA,NA,p.Thr190Gln,0.8537958520000001,5.5e-22,1.3899999999999998e-42,-0.8537958520000001 +urn:mavedb:00000041-a-1#155,NA,NA,p.Thr190Asp,1.282618499,0.333250313,1.96e-07,-1.282618499 +urn:mavedb:00000041-a-1#156,NA,NA,p.Thr190Arg,1.6458950719999998,0.0032810240000000004,4.11e-07,-1.6458950719999998 +urn:mavedb:00000041-a-1#157,NA,NA,p.Thr187Ter,1.743404766,0.0007490789999999999,5.43e-08,-1.743404766 +urn:mavedb:00000041-a-1#158,NA,NA,p.Thr187Ser,0.462209152,2.0199999999999998e-42,1.3699999999999992e-82,-0.462209152 +urn:mavedb:00000041-a-1#159,NA,NA,p.Thr187Pro,1.394511159,3.97e-14,2.84e-27,-1.394511159 +urn:mavedb:00000041-a-1#160,NA,NA,p.Thr187Lys,1.115512555,1.65e-09,2.27e-18,-1.115512555 +urn:mavedb:00000041-a-1#161,NA,NA,p.Thr187Leu,0.642558714,1.23e-12,2.04e-24,-0.642558714 +urn:mavedb:00000041-a-1#162,NA,NA,p.Thr187Gly,0.468582556,2.9500000000000004e-20,3.21e-39,-0.468582556 +urn:mavedb:00000041-a-1#163,NA,NA,p.Thr187Glu,0.5728492820000001,1.2299999999999997e-86,2.819999999999998e-169,-0.5728492820000001 +urn:mavedb:00000041-a-1#164,NA,NA,p.Thr187Arg,0.486533659,0.002444884,1.53e-07,-0.486533659 +urn:mavedb:00000041-a-1#165,NA,NA,p.Thr174Ter,1.58372737,7.789999999999999e-13,9.02e-25,-1.58372737 +urn:mavedb:00000041-a-1#166,NA,NA,p.Thr174Pro,0.861406815,6.39e-11,4.35e-21,-0.861406815 +urn:mavedb:00000041-a-1#167,NA,NA,p.Thr174Glu,0.960398953,0.214494823,0.000229202,-0.960398953 +urn:mavedb:00000041-a-1#168,NA,NA,p.Thr174Asp,0.781094332,1.6299999999999993e-28,2.4299999999999996e-55,-0.781094332 +urn:mavedb:00000041-a-1#169,NA,NA,p.Thr163Val,1.528882525,9.78e-14,1.6299999999999997e-26,-1.528882525 +urn:mavedb:00000041-a-1#170,NA,NA,p.Thr163Tyr,1.5920066330000002,1.3300000000000002e-09,1.51e-18,-1.5920066330000002 +urn:mavedb:00000041-a-1#171,NA,NA,p.Thr163Trp,1.635521059,6.82e-08,2.73e-15,-1.635521059 +urn:mavedb:00000041-a-1#172,NA,NA,p.Thr163Ter,1.613940842,1.4400000000000001e-15,4.5199999999999995e-30,-1.613940842 +urn:mavedb:00000041-a-1#173,NA,NA,p.Thr163Ser,1.129793185,4.5e-26,1.4599999999999994e-50,-1.129793185 +urn:mavedb:00000041-a-1#174,NA,NA,p.Thr163Pro,1.576771136,1.3000000000000002e-10,1.76e-20,-1.576771136 +urn:mavedb:00000041-a-1#175,NA,NA,p.Thr163Phe,1.587242649,4.48e-08,1.24e-15,-1.587242649 +urn:mavedb:00000041-a-1#176,NA,NA,p.Thr163Met,1.671838484,7.19e-07,2.3100000000000003e-13,-1.671838484 +urn:mavedb:00000041-a-1#196,NA,NA,p.Thr151Arg,0.532962553,0.26867070600000004,1.97e-13,-0.532962553 +urn:mavedb:00000041-a-1#197,NA,NA,p.Thr151Ala,0.845214245,6.78e-12,5.689999999999999e-23,-0.845214245 +urn:mavedb:00000041-a-1#198,NA,NA,p.Thr88Ter,1.593173665,2.13e-23,2.46e-45,-1.593173665 +urn:mavedb:00000041-a-1#199,NA,NA,p.Thr72Asn,1.410902741,2.05e-11,4.9699999999999995e-22,-1.410902741 +urn:mavedb:00000041-a-1#200,NA,NA,p.Thr72Arg,0.782558676,0.00033260300000000005,1.36e-08,-0.782558676 +urn:mavedb:00000041-a-1#201,NA,NA,p.Thr35Val,1.0950975,2.8000000000000004e-21,3.3799999999999987e-41,-1.0950975 +urn:mavedb:00000041-a-1#202,NA,NA,p.Thr35Ter,1.652852151,1.33e-07,9.66e-15,-1.652852151 +urn:mavedb:00000041-a-1#203,NA,NA,p.Thr35Phe,0.708184369,2.29e-24,3.1199999999999997e-47,-0.708184369 +urn:mavedb:00000041-a-1#204,NA,NA,p.Thr35Leu,1.117309663,2.9399999999999997e-26,6.37e-51,-1.117309663 +urn:mavedb:00000041-a-1#205,NA,NA,p.Thr35Ile,1.213077918,1.19e-30,1.62e-59,-1.213077918 +urn:mavedb:00000041-a-1#206,NA,NA,p.Thr35Cys,0.829142906,0.500495504,1.67e-16,-0.829142906 +urn:mavedb:00000041-a-1#207,NA,NA,p.Thr30Val,1.327331554,3.44e-10,1.1300000000000002e-19,-1.327331554 +urn:mavedb:00000041-a-1#208,NA,NA,p.Thr30Ter,1.7550930580000002,0.002264891,2.47e-07,-1.7550930580000002 +urn:mavedb:00000041-a-1#209,NA,NA,p.Thr30Ser,0.647520854,1.17e-20,5.3699999999999996e-40,-0.647520854 +urn:mavedb:00000041-a-1#210,NA,NA,p.Thr30Pro,1.665689354,2.12e-05,1.2e-10,-1.665689354 +urn:mavedb:00000041-a-1#211,NA,NA,p.Thr30Ile,1.334015653,6.23e-05,8.210000000000001e-10,-1.334015653 +urn:mavedb:00000041-a-1#212,NA,NA,p.Thr30Glu,0.8113333420000001,6.32e-08,2.1399999999999997e-15,-0.8113333420000001 +urn:mavedb:00000041-a-1#214,NA,NA,p.Thr30Asp,0.549619772,2.79e-19,2.6e-37,-0.549619772 +urn:mavedb:00000041-a-1#215,NA,NA,p.Thr30Ala,1.019337446,3.8e-20,5.44e-39,-1.019337446 +urn:mavedb:00000041-a-1#216,NA,NA,p.Thr24Val,0.546890365,1.55e-07,1.19e-14,-0.546890365 +urn:mavedb:00000041-a-1#217,NA,NA,p.Ser181Gly,0.869896105,2.45e-30,6.54e-59,-0.869896105 +urn:mavedb:00000041-a-1#218,NA,NA,p.Ser181Glu,1.449688506,1.41e-11,2.4e-22,-1.449688506 +urn:mavedb:00000041-a-1#219,NA,NA,p.Ser181Gln,1.312605532,9.66e-19,3.01e-36,-1.312605532 +urn:mavedb:00000041-a-1#220,NA,NA,p.Ser181Cys,0.7519800440000001,3.7299999999999994e-44,5.559999999999998e-86,-0.7519800440000001 +urn:mavedb:00000041-a-1#221,NA,NA,p.Ser181Asp,1.581173839,3.74e-08,8.759999999999998e-16,-1.581173839 +urn:mavedb:00000041-a-1#222,NA,NA,p.Ser181Asn,1.583879413,2.11e-08,2.94e-16,-1.583879413 +urn:mavedb:00000041-a-1#223,NA,NA,p.Ser181Arg,1.566774198,4.84e-09,1.8e-17,-1.566774198 +urn:mavedb:00000041-a-1#224,NA,NA,p.Ser181Ala,1.053969511,4.41e-26,1.4e-50,-1.053969511 +urn:mavedb:00000041-a-1#225,NA,NA,p.Ser177Val,1.144471369,0.701576306,2.22e-16,-1.144471369 +urn:mavedb:00000041-a-1#226,NA,NA,p.Ser177Tyr,1.4588866740000002,0.008741825,5.58e-08,-1.4588866740000002 +urn:mavedb:00000041-a-1#227,NA,NA,p.Ser177Pro,1.600353249,1.17e-05,4.08e-11,-1.600353249 +urn:mavedb:00000041-a-1#247,NA,NA,p.Ser79Ala,0.7287711090000001,2.94e-13,1.31e-25,-0.7287711090000001 +urn:mavedb:00000041-a-1#248,NA,NA,p.Ser64Val,1.2307175609999998,6.800000000000001e-17,1.1799999999999997e-32,-1.2307175609999998 +urn:mavedb:00000041-a-1#249,NA,NA,p.Ser64Thr,0.779794124,1.15e-44,5.5599999999999985e-87,-0.779794124 +urn:mavedb:00000041-a-1#2012,NA,NA,p.Thr187Asn,-0.134733145,1.17e-20,5.17e-40,0.134733145 +urn:mavedb:00000041-a-1#250,NA,NA,p.Ser64Ter,1.795077073,0.6427843639999999,0.0,-1.795077073 +urn:mavedb:00000041-a-1#2043,NA,NA,p.Thr35Tyr,-0.060886956,0.396501478,0.0,0.060886956 +urn:mavedb:00000041-a-1#251,NA,NA,p.Ser64Pro,1.179407459,1.45e-16,5.219999999999998e-32,-1.179407459 +urn:mavedb:00000041-a-1#252,NA,NA,p.Ser64Phe,0.963091182,1.04e-24,6.7e-48,-0.963091182 +urn:mavedb:00000041-a-1#253,NA,NA,p.Ser64Met,0.965221043,3.87e-07,7.07e-14,-0.965221043 +urn:mavedb:00000041-a-1#254,NA,NA,p.Ser64Lys,1.276932855,2.64e-42,2.3999999999999992e-82,-1.276932855 +urn:mavedb:00000041-a-1#255,NA,NA,p.Ser64Leu,1.344316356,8.59e-08,4.19e-15,-1.344316356 +urn:mavedb:00000041-a-1#2134,NA,NA,p.Thr24Cys,0.335883603,0.216007274,1.39e-17,-0.335883603 +urn:mavedb:00000041-a-1#256,NA,NA,p.Ser64Ile,1.320153825,0.000514619,3.04e-08,-1.320153825 +urn:mavedb:00000041-a-1#257,NA,NA,p.Ser64Gly,1.365598826,8.31e-11,7.32e-21,-1.365598826 +urn:mavedb:00000041-a-1#258,NA,NA,p.Ser64Gln,0.478223889,2.35e-13,8.53e-26,-0.478223889 +urn:mavedb:00000041-a-1#259,NA,NA,p.Ser64Asp,0.938179591,3.34e-12,1.4599999999999995e-23,-0.938179591 +urn:mavedb:00000041-a-1#260,NA,NA,p.Ser64Asn,0.8577059340000001,7.01e-30,5.17e-58,-0.8577059340000001 +urn:mavedb:00000041-a-1#262,NA,NA,p.Ser64Ala,1.279162679,7.78e-15,1.1999999999999999e-28,-1.279162679 +urn:mavedb:00000041-a-1#263,NA,NA,p.Ser37Val,1.170765922,2.0800000000000003e-09,3.47e-18,-1.170765922 +urn:mavedb:00000041-a-1#264,NA,NA,p.Ser37Tyr,0.8715246940000001,3.87e-35,2.6199999999999997e-68,-0.8715246940000001 +urn:mavedb:00000041-a-1#265,NA,NA,p.Ser37Trp,0.736458042,3.8999999999999996e-54,1.4999999999999989e-105,-0.736458042 +urn:mavedb:00000041-a-1#266,NA,NA,p.Ser37Ter,1.606253538,0.025435335,2.5e-05,-1.606253538 +urn:mavedb:00000041-a-1#267,NA,NA,p.Ser37Lys,1.201811665,1.95e-15,8.07e-30,-1.201811665 +urn:mavedb:00000041-a-1#268,NA,NA,p.Ser37Leu,0.606314631,2.2999999999999998e-23,2.8199999999999996e-45,-0.606314631 +urn:mavedb:00000041-a-1#269,NA,NA,p.Ser37Ile,1.193327642,5.48e-22,1.3999999999999995e-42,-1.193327642 +urn:mavedb:00000041-a-1#270,NA,NA,p.Ser37Gln,0.856018975,9.15e-11,8.550000000000001e-21,-0.856018975 +urn:mavedb:00000041-a-1#271,NA,NA,p.Ser37Asn,1.3432706580000002,7.640000000000001e-09,4.1799999999999996e-17,-1.3432706580000002 +urn:mavedb:00000041-a-1#272,NA,NA,p.Ser37Arg,0.81613958,1.3099999999999999e-23,9.549999999999999e-46,-0.81613958 +urn:mavedb:00000041-a-1#273,NA,NA,p.Pro241Val,0.90846463,1.85e-08,2.2e-16,-0.90846463 +urn:mavedb:00000041-a-1#274,NA,NA,p.Pro241Tyr,1.276119677,0.278204763,0.0027784040000000004,-1.276119677 +urn:mavedb:00000041-a-1#275,NA,NA,p.Pro241Leu,1.175340802,1.83e-09,2.6e-18,-1.175340802 +urn:mavedb:00000041-a-1#276,NA,NA,p.Pro241Cys,0.549925924,2.689999999999999e-37,1.5399999999999994e-72,-0.549925924 +urn:mavedb:00000041-a-1#277,NA,NA,p.Pro241Arg,0.573852891,1.87e-19,1.19e-37,-0.573852891 +urn:mavedb:00000041-a-1#278,NA,NA,p.Pro241Ala,0.8813323209999999,6.86e-20,1.7099999999999995e-38,-0.8813323209999999 +urn:mavedb:00000041-a-1#279,NA,NA,p.Pro237Ter,1.628112045,0.0021547470000000003,2.55e-07,-1.628112045 +urn:mavedb:00000041-a-1#280,NA,NA,p.Pro222Val,0.553572704,6.75e-05,8.39e-10,-0.553572704 +urn:mavedb:00000041-a-1#281,NA,NA,p.Pro222Trp,0.7471001709999999,2.2e-18,1.5e-35,-0.7471001709999999 +urn:mavedb:00000041-a-1#282,NA,NA,p.Pro222Thr,0.462366875,1.41e-47,1.0899999999999999e-92,-0.462366875 +urn:mavedb:00000041-a-1#283,NA,NA,p.Pro222Ter,1.621545988,8.609999999999997e-12,9.34e-23,-1.621545988 +urn:mavedb:00000041-a-1#284,NA,NA,p.Pro222Ser,0.589884075,6.92e-07,2.02e-13,-0.589884075 +urn:mavedb:00000041-a-1#285,NA,NA,p.Pro222Phe,0.596099198,9.45e-22,3.95e-42,-0.596099198 +urn:mavedb:00000041-a-1#286,NA,NA,p.Pro222Leu,0.773840922,0.211717955,2.23e-15,-0.773840922 +urn:mavedb:00000041-a-1#287,NA,NA,p.Pro222His,0.962022586,1.06e-37,2.4799999999999998e-73,-0.962022586 +urn:mavedb:00000041-a-1#288,NA,NA,p.Pro222Gly,0.933324468,5.25e-16,6.29e-31,-0.933324468 +urn:mavedb:00000041-a-1#303,NA,NA,p.Pro218Arg,0.942109963,2.56e-15,1.3699999999999998e-29,-0.942109963 +urn:mavedb:00000041-a-1#304,NA,NA,p.Pro216Trp,0.601263922,4.15e-16,3.87e-31,-0.601263922 +urn:mavedb:00000041-a-1#305,NA,NA,p.Pro216Ter,1.680358286,2.19e-12,6.63e-24,-1.680358286 +urn:mavedb:00000041-a-1#306,NA,NA,p.Pro198Thr,0.653819731,4.4600000000000006e-27,1.55e-52,-0.653819731 +urn:mavedb:00000041-a-1#307,NA,NA,p.Pro198Ter,1.648235476,7.68e-07,2.6e-13,-1.648235476 +urn:mavedb:00000041-a-1#308,NA,NA,p.Pro198Ser,0.5810436370000001,2.91e-14,1.48e-27,-0.5810436370000001 +urn:mavedb:00000041-a-1#309,NA,NA,p.Pro198Lys,0.832271257,2.28e-10,5.0599999999999995e-20,-0.832271257 +urn:mavedb:00000041-a-1#310,NA,NA,p.Pro198Ile,0.472977167,1.0199999999999996e-39,2.889999999999999e-77,-0.472977167 +urn:mavedb:00000041-a-1#311,NA,NA,p.Pro198Glu,0.645009174,3.1499999999999997e-34,1.5699999999999992e-66,-0.645009174 +urn:mavedb:00000041-a-1#312,NA,NA,p.Pro198Gln,0.623453147,1.7e-26,2.1199999999999995e-51,-0.623453147 +urn:mavedb:00000041-a-1#313,NA,NA,p.Pro198Asp,0.957670341,3.88e-10,1.37e-19,-0.957670341 +urn:mavedb:00000041-a-1#314,NA,NA,p.Pro198Asn,0.8986561479999999,5.699999999999998e-68,1.1699999999999992e-132,-0.8986561479999999 +urn:mavedb:00000041-a-1#315,NA,NA,p.Pro198Arg,1.027318281,7.66e-16,1.3099999999999999e-30,-1.027318281 +urn:mavedb:00000041-a-1#316,NA,NA,p.Pro196Tyr,1.526837839,5.77e-10,3.06e-19,-1.526837839 +urn:mavedb:00000041-a-1#317,NA,NA,p.Pro196Trp,1.449496516,4.39e-10,1.81e-19,-1.449496516 +urn:mavedb:00000041-a-1#318,NA,NA,p.Pro196Thr,1.325296167,4.7e-13,3.3600000000000006e-25,-1.325296167 +urn:mavedb:00000041-a-1#319,NA,NA,p.Pro196Ter,1.6284736830000002,0.048508425,0.00014638,-1.6284736830000002 +urn:mavedb:00000041-a-1#320,NA,NA,p.Pro196Ser,1.5901199869999998,6.33e-12,5.16e-23,-1.5901199869999998 +urn:mavedb:00000041-a-1#334,NA,NA,p.Pro165Lys,0.826715366,3.03e-49,5.9799999999999995e-96,-0.826715366 +urn:mavedb:00000041-a-1#335,NA,NA,p.Pro165Asp,1.6487883980000002,0.044340809,0.000124687,-1.6487883980000002 +urn:mavedb:00000041-a-1#336,NA,NA,p.Pro159Tyr,2.08354868,1.076065399,0.0,-2.08354868 +urn:mavedb:00000041-a-1#337,NA,NA,p.Pro159Thr,1.584564822,0.006135324,5.529999999999999e-07,-1.584564822 +urn:mavedb:00000041-a-1#2135,NA,NA,p.Thr24Asn,-0.437196715,4.46e-08,1.24e-15,0.437196715 +urn:mavedb:00000041-a-1#338,NA,NA,p.Pro159Ser,1.471101251,6.13e-08,2.23e-15,-1.471101251 +urn:mavedb:00000041-a-1#339,NA,NA,p.Pro159Phe,1.476925959,5.89e-05,7.55e-10,-1.476925959 +urn:mavedb:00000041-a-1#340,NA,NA,p.Pro159Leu,1.849452357,0.038694574,9.41e-05,-1.849452357 +urn:mavedb:00000041-a-1#341,NA,NA,p.Pro159His,1.655611453,6.499999999999999e-12,5.44e-23,-1.655611453 +urn:mavedb:00000041-a-1#342,NA,NA,p.Pro159Asn,1.46460647,6.45e-10,3.8e-19,-1.46460647 +urn:mavedb:00000041-a-1#343,NA,NA,p.Pro95Val,0.51417407,3.98e-14,2.68e-27,-0.51417407 +urn:mavedb:00000041-a-1#344,NA,NA,p.Pro95Met,0.461472645,9.02e-06,2.24e-11,-0.461472645 +urn:mavedb:00000041-a-1#370,NA,NA,p.Phe249Lys,0.664671154,2.9100000000000006e-05,2e-10,-0.664671154 +urn:mavedb:00000041-a-1#371,NA,NA,p.Phe249Gly,0.736368122,4.469999999999999e-12,2.59e-23,-0.736368122 +urn:mavedb:00000041-a-1#2136,NA,NA,p.Thr24Ala,0.291140611,9.15e-15,1.57e-28,-0.291140611 +urn:mavedb:00000041-a-1#2137,NA,NA,p.Thr23Ser,0.145924221,0.387327403,0.0,-0.145924221 +urn:mavedb:00000041-a-1#372,NA,NA,p.Phe249Gln,1.198634157,1.387210499,4.44e-16,-1.198634157 +urn:mavedb:00000041-a-1#373,NA,NA,p.Phe249Cys,0.724249403,1.24e-29,1.55e-57,-0.724249403 +urn:mavedb:00000041-a-1#374,NA,NA,p.Phe249Asn,0.7361191029999999,3.510000000000001e-13,1.89e-25,-0.7361191029999999 +urn:mavedb:00000041-a-1#375,NA,NA,p.Phe249Arg,0.798103042,1.72e-08,1.92e-16,-0.798103042 +urn:mavedb:00000041-a-1#376,NA,NA,p.Phe249Ala,0.531046047,6.73e-32,5.8899999999999975e-62,-0.531046047 +urn:mavedb:00000041-a-1#377,NA,NA,p.Phe243Ter,1.526968408,2.05e-08,2.81e-16,-1.526968408 +urn:mavedb:00000041-a-1#378,NA,NA,p.Phe243Lys,1.467022069,5.079999999999999e-19,8.669999999999998e-37,-1.467022069 +urn:mavedb:00000041-a-1#379,NA,NA,p.Phe243Gly,1.240168615,9.78e-06,2.73e-11,-1.240168615 +urn:mavedb:00000041-a-1#380,NA,NA,p.Phe243Gln,1.009524436,9.67e-07,3.82e-13,-1.009524436 +urn:mavedb:00000041-a-1#387,NA,NA,p.Phe182Pro,1.6199749819999998,0.000160738,4.42e-09,-1.6199749819999998 +urn:mavedb:00000041-a-1#388,NA,NA,p.Phe182Lys,1.605004766,2.37e-09,4.56e-18,-1.605004766 +urn:mavedb:00000041-a-1#389,NA,NA,p.Phe182His,1.439689382,3.57e-10,1.1999999999999999e-19,-1.439689382 +urn:mavedb:00000041-a-1#395,NA,NA,p.Phe182Asn,1.709104419,0.000466085,2.52e-08,-1.709104419 +urn:mavedb:00000041-a-1#396,NA,NA,p.Phe182Arg,1.630966712,9.87e-11,1.02e-20,-1.630966712 +urn:mavedb:00000041-a-1#397,NA,NA,p.Phe182Ala,0.515175735,9.29e-49,5.2499999999999976e-95,-0.515175735 +urn:mavedb:00000041-a-1#398,NA,NA,p.Phe173Tyr,0.623670591,1.1299999999999996e-109,1.9399999999999984e-214,-0.623670591 +urn:mavedb:00000041-a-1#399,NA,NA,p.Phe173Thr,1.020177961,3.41e-22,5.51e-43,-1.020177961 +urn:mavedb:00000041-a-1#400,NA,NA,p.Phe173Ter,1.6175025580000002,4e-08,1e-15,-1.6175025580000002 +urn:mavedb:00000041-a-1#401,NA,NA,p.Phe173Ser,0.5257164910000001,2.32e-11,6.04e-22,-0.5257164910000001 +urn:mavedb:00000041-a-1#402,NA,NA,p.Phe173Pro,1.37515492,2.66e-22,3.3999999999999997e-43,-1.37515492 +urn:mavedb:00000041-a-1#403,NA,NA,p.Phe173Met,1.47938054,9.75e-06,2.79e-11,-1.47938054 +urn:mavedb:00000041-a-1#404,NA,NA,p.Phe173Lys,1.544004121,3.75e-17,3.76e-33,-1.544004121 +urn:mavedb:00000041-a-1#405,NA,NA,p.Phe173Leu,1.307898241,1.1e-20,4.88e-40,-1.307898241 +urn:mavedb:00000041-a-1#406,NA,NA,p.Phe173Ile,0.8007565590000001,0.289502685,1.3e-06,-0.8007565590000001 +urn:mavedb:00000041-a-1#2257,NA,NA,p.Leu246Phe,0.192801257,1.44e-08,1.32e-16,-0.192801257 +urn:mavedb:00000041-a-1#2258,NA,NA,p.Leu246Met,0.21384727,4.1e-31,1.85e-60,-0.21384727 +urn:mavedb:00000041-a-1#409,NA,NA,p.Val209Lys,1.5632409230000002,5.66e-11,3.4999999999999996e-21,-1.5632409230000002 +urn:mavedb:00000041-a-1#410,NA,NA,p.Val209Gly,1.45268489,1.42e-09,1.71e-18,-1.45268489 +urn:mavedb:00000041-a-1#411,NA,NA,p.Val209Glu,1.414248939,1.23e-15,3.32e-30,-1.414248939 +urn:mavedb:00000041-a-1#426,NA,NA,p.Val136His,1.479123584,1.24e-14,2.97e-28,-1.479123584 +urn:mavedb:00000041-a-1#427,NA,NA,p.Val136Gly,1.49429265,1.21e-08,1.03e-16,-1.49429265 +urn:mavedb:00000041-a-1#428,NA,NA,p.Val136Glu,1.61762698,1.51e-08,1.57e-16,-1.61762698 +urn:mavedb:00000041-a-1#429,NA,NA,p.Val136Gln,1.529292135,0.001764414,2.08e-07,-1.529292135 +urn:mavedb:00000041-a-1#430,NA,NA,p.Val136Cys,1.132910841,1.26e-10,1.6000000000000002e-20,-1.132910841 +urn:mavedb:00000041-a-1#431,NA,NA,p.Val136Asp,1.6230140240000002,5.96e-10,3.27e-19,-1.6230140240000002 +urn:mavedb:00000041-a-1#432,NA,NA,p.Val136Asn,1.677209539,0.091749093,0.0006131730000000001,-1.677209539 +urn:mavedb:00000041-a-1#433,NA,NA,p.Val136Arg,1.574523448,1.37e-14,3.57e-28,-1.574523448 +urn:mavedb:00000041-a-1#434,NA,NA,p.Val136Ala,1.3151254490000002,2.65e-15,1.47e-29,-1.3151254490000002 +urn:mavedb:00000041-a-1#435,NA,NA,p.Val133Ter,1.483655514,5.47e-09,2.2699999999999998e-17,-1.483655514 +urn:mavedb:00000041-a-1#436,NA,NA,p.Val133Pro,0.949820961,0.368551918,2.78e-17,-0.949820961 +urn:mavedb:00000041-a-1#437,NA,NA,p.Val128Tyr,1.046498861,1.9699999999999996e-74,2.4799999999999988e-145,-1.046498861 +urn:mavedb:00000041-a-1#438,NA,NA,p.Val128Trp,1.006480398,0.489014389,3.97e-09,-1.006480398 +urn:mavedb:00000041-a-1#439,NA,NA,p.Val128Thr,0.71822381,1.28e-07,8.57e-15,-0.71822381 +urn:mavedb:00000041-a-1#452,NA,NA,p.Val128Asn,1.432521895,6.3900000000000005e-09,3e-17,-1.432521895 +urn:mavedb:00000041-a-1#453,NA,NA,p.Val128Arg,1.3416235909999998,1.25e-15,3.44e-30,-1.3416235909999998 +urn:mavedb:00000041-a-1#454,NA,NA,p.Val128Ala,0.70785972,6.94e-41,1.4199999999999993e-79,-0.70785972 +urn:mavedb:00000041-a-1#455,NA,NA,p.Val117Tyr,1.546812681,2.22e-16,1.2e-31,-1.546812681 +urn:mavedb:00000041-a-1#2618,NA,NA,p.Val201Glu,-0.518665293,0.43860446,0.0,0.518665293 +urn:mavedb:00000041-a-1#456,NA,NA,p.Val117Trp,1.709259635,1.66e-08,1.85e-16,-1.709259635 +urn:mavedb:00000041-a-1#457,NA,NA,p.Val117Thr,0.913267086,5.24e-46,1.3199999999999993e-89,-0.913267086 +urn:mavedb:00000041-a-1#458,NA,NA,p.Val117Ser,1.394869204,8.54e-15,1.43e-28,-1.394869204 +urn:mavedb:00000041-a-1#459,NA,NA,p.Val117Pro,1.601114884,1.22e-12,2.15e-24,-1.601114884 +urn:mavedb:00000041-a-1#460,NA,NA,p.Val117Phe,1.336646998,8.89e-16,1.77e-30,-1.336646998 +urn:mavedb:00000041-a-1#461,NA,NA,p.Val117Met,1.05891425,3.74e-60,2.4599999999999988e-117,-1.05891425 +urn:mavedb:00000041-a-1#462,NA,NA,p.Val117Lys,1.612955972,5.81e-07,1.55e-13,-1.612955972 +urn:mavedb:00000041-a-1#463,NA,NA,p.Val117Leu,0.521445321,0.187317972,2.47e-06,-0.521445321 +urn:mavedb:00000041-a-1#464,NA,NA,p.Val117His,1.51556374,5.88e-13,5.23e-25,-1.51556374 +urn:mavedb:00000041-a-1#36,NA,NA,p.Tyr170Gly,0.753146338,0.148892394,1.46e-05,-0.753146338 +urn:mavedb:00000041-a-1#37,NA,NA,p.Tyr170Glu,0.5468629620000001,2.83e-18,2.3199999999999998e-35,-0.5468629620000001 +urn:mavedb:00000041-a-1#38,NA,NA,p.Tyr170Asn,0.558748516,3.8e-13,2.14e-25,-0.558748516 +urn:mavedb:00000041-a-1#39,NA,NA,p.Tyr170Ala,0.765848309,1.6200000000000002e-13,4.1599999999999997e-26,-0.765848309 +urn:mavedb:00000041-a-1#40,NA,NA,p.Tyr150Val,1.488196285,1.67e-08,1.88e-16,-1.488196285 +urn:mavedb:00000041-a-1#41,NA,NA,p.Tyr150Trp,1.509827165,2.1e-09,3.64e-18,-1.509827165 +urn:mavedb:00000041-a-1#42,NA,NA,p.Tyr150Thr,1.455301391,7.92e-14,1.08e-26,-1.455301391 +urn:mavedb:00000041-a-1#43,NA,NA,p.Tyr150Ter,1.744772321,3.73e-10,1.31e-19,-1.744772321 +urn:mavedb:00000041-a-1#44,NA,NA,p.Tyr150Ser,1.529252461,7.45e-11,5.95e-21,-1.529252461 +urn:mavedb:00000041-a-1#45,NA,NA,p.Tyr150Pro,1.5199066490000002,1.53e-10,2.39e-20,-1.5199066490000002 +urn:mavedb:00000041-a-1#46,NA,NA,p.Tyr150Phe,1.5641348659999998,1.6300000000000002e-27,2.22e-53,-1.5641348659999998 +urn:mavedb:00000041-a-1#47,NA,NA,p.Tyr150Met,1.572171451,0.00011298,2.38e-09,-1.572171451 +urn:mavedb:00000041-a-1#48,NA,NA,p.Tyr150Lys,1.54210648,5.21e-09,2.05e-17,-1.54210648 +urn:mavedb:00000041-a-1#49,NA,NA,p.Tyr150Leu,1.511930319,2.71e-14,1.34e-27,-1.511930319 +urn:mavedb:00000041-a-1#65,NA,NA,p.Tyr116Arg,1.468581832,1.49e-16,5.5e-32,-1.468581832 +urn:mavedb:00000041-a-1#66,NA,NA,p.Tyr110Val,1.140674142,0.21940684,2.81e-08,-1.140674142 +urn:mavedb:00000041-a-1#68,NA,NA,p.Tyr110Ser,0.723516705,2.34e-13,8.450000000000001e-26,-0.723516705 +urn:mavedb:00000041-a-1#69,NA,NA,p.Tyr110Pro,1.580008854,6.629999999999999e-07,1.99e-13,-1.580008854 +urn:mavedb:00000041-a-1#70,NA,NA,p.Tyr110Met,0.8259501109999999,5.36e-46,1.3899999999999997e-89,-0.8259501109999999 +urn:mavedb:00000041-a-1#71,NA,NA,p.Tyr110Leu,0.902536229,1.97e-22,1.89e-43,-0.902536229 +urn:mavedb:00000041-a-1#72,NA,NA,p.Tyr110Ile,0.698935581,9.310000000000001e-48,4.849999999999998e-93,-0.698935581 +urn:mavedb:00000041-a-1#77,NA,NA,p.Tyr110Asn,0.924227762,2.9899999999999994e-23,4.7499999999999995e-45,-0.924227762 +urn:mavedb:00000041-a-1#1854,NA,NA,p.Val195Asp,0.332329347,1.29e-05,4.53e-11,-0.332329347 +urn:mavedb:00000041-a-1#78,NA,NA,p.Tyr110Arg,0.875522039,3.02e-48,5.369999999999998e-94,-0.875522039 +urn:mavedb:00000041-a-1#79,NA,NA,p.Tyr110Ala,0.591723696,1.82e-09,2.77e-18,-0.591723696 +urn:mavedb:00000041-a-1#80,NA,NA,p.Tyr91Ter,1.478470994,1.49e-13,3.6600000000000005e-26,-1.478470994 +urn:mavedb:00000041-a-1#81,NA,NA,p.Tyr69Ser,1.35436486,6.019999999999998e-16,8.21e-31,-1.35436486 +urn:mavedb:00000041-a-1#86,NA,NA,p.Tyr60Pro,1.518885441,2.34e-12,7.51e-24,-1.518885441 +urn:mavedb:00000041-a-1#87,NA,NA,p.Tyr60Asp,0.811910068,3.65e-18,3.9799999999999996e-35,-0.811910068 +urn:mavedb:00000041-a-1#88,NA,NA,p.Trp233Val,0.949305871,4.6500000000000006e-12,2.79e-23,-0.949305871 +urn:mavedb:00000041-a-1#1916,NA,NA,p.Val5Lys,-0.566249298,0.305988388,1.63e-11,0.566249298 +urn:mavedb:00000041-a-1#89,NA,NA,p.Trp233Tyr,0.8288126090000001,2.8500000000000005e-23,4.3e-45,-0.8288126090000001 +urn:mavedb:00000041-a-1#90,NA,NA,p.Trp233Ter,1.602463946,1.51e-10,2.34e-20,-1.602463946 +urn:mavedb:00000041-a-1#91,NA,NA,p.Trp233Pro,1.652918486,2.12e-08,3e-16,-1.652918486 +urn:mavedb:00000041-a-1#92,NA,NA,p.Trp233Phe,0.947601333,1.24e-23,8.579999999999997e-46,-0.947601333 +urn:mavedb:00000041-a-1#93,NA,NA,p.Trp233Met,0.814550435,2.6200000000000003e-28,6.13e-55,-0.814550435 +urn:mavedb:00000041-a-1#94,NA,NA,p.Trp233Lys,1.50885581,0.032346237,4.26e-05,-1.50885581 +urn:mavedb:00000041-a-1#99,NA,NA,p.Trp233Asp,1.042042644,4.56e-06,7e-12,-1.042042644 +urn:mavedb:00000041-a-1#100,NA,NA,p.Trp233Arg,1.669412514,2.26e-05,1.32e-10,-1.669412514 +urn:mavedb:00000041-a-1#1948,NA,NA,p.Tyr110Lys,0.22520067,0.56648791,0.0,-0.22520067 +urn:mavedb:00000041-a-1#101,NA,NA,p.Trp233Ala,0.581298059,5.229999999999999e-15,5.340000000000001e-29,-0.581298059 +urn:mavedb:00000041-a-1#102,NA,NA,p.Trp180Val,1.688183245,1.29e-15,3.64e-30,-1.688183245 +urn:mavedb:00000041-a-1#103,NA,NA,p.Trp180Thr,1.6561081359999998,8.73e-10,6.720000000000001e-19,-1.6561081359999998 +urn:mavedb:00000041-a-1#104,NA,NA,p.Trp180Ter,1.662374816,8.16e-06,2.07e-11,-1.662374816 +urn:mavedb:00000041-a-1#105,NA,NA,p.Trp180Ser,1.62532519,3.79e-09,1.1199999999999999e-17,-1.62532519 +urn:mavedb:00000041-a-1#106,NA,NA,p.Trp180Pro,1.5282504069999998,2.11e-13,7.19e-26,-1.5282504069999998 +urn:mavedb:00000041-a-1#107,NA,NA,p.Trp180Met,1.525178049,1.0800000000000003e-05,3.52e-11,-1.525178049 +urn:mavedb:00000041-a-1#108,NA,NA,p.Trp180Lys,1.5251165569999998,7.170000000000001e-13,7.68e-25,-1.5251165569999998 +urn:mavedb:00000041-a-1#109,NA,NA,p.Trp180Leu,1.576809052,3.1e-11,1.11e-21,-1.576809052 +urn:mavedb:00000041-a-1#110,NA,NA,p.Trp180His,0.7676088440000001,1.33e-29,1.81e-57,-0.7676088440000001 +urn:mavedb:00000041-a-1#111,NA,NA,p.Trp180Gly,1.631200415,0.00017645,5.1900000000000005e-09,-1.631200415 +urn:mavedb:00000041-a-1#112,NA,NA,p.Trp180Glu,1.449309786,2.01e-20,1.6e-39,-1.449309786 +urn:mavedb:00000041-a-1#131,NA,NA,p.Trp162Glu,1.486656627,2.18e-18,1.4699999999999998e-35,-1.486656627 +urn:mavedb:00000041-a-1#132,NA,NA,p.Trp162Gln,1.501140935,1.35e-10,1.8799999999999998e-20,-1.501140935 +urn:mavedb:00000041-a-1#133,NA,NA,p.Trp162Cys,1.499795929,2.07e-11,5.06e-22,-1.499795929 +urn:mavedb:00000041-a-1#134,NA,NA,p.Trp162Asp,1.599886577,0.008888125,2.56e-08,-1.599886577 +urn:mavedb:00000041-a-1#135,NA,NA,p.Trp162Asn,1.454255183,5.889999999999998e-17,9.03e-33,-1.454255183 +urn:mavedb:00000041-a-1#136,NA,NA,p.Trp162Arg,1.5418442769999998,2.66e-14,1.2999999999999999e-27,-1.5418442769999998 +urn:mavedb:00000041-a-1#137,NA,NA,p.Trp162Ala,1.447536831,2.8100000000000004e-09,6.36e-18,-1.447536831 +urn:mavedb:00000041-a-1#138,NA,NA,p.Trp20Ter,1.664417487,2.24e-14,9.3e-28,-1.664417487 +urn:mavedb:00000041-a-1#139,NA,NA,p.Trp16Ter,1.578103745,0.19644918100000006,0.00122922,-1.578103745 +urn:mavedb:00000041-a-1#140,NA,NA,p.Trp16Pro,1.654951499,9.08e-10,7.29e-19,-1.654951499 +urn:mavedb:00000041-a-1#1951,NA,NA,p.Tyr91Met,0.053891122,3.04e-14,1.58e-27,-0.053891122 +urn:mavedb:00000041-a-1#141,NA,NA,p.Thr242Ter,1.661570371,0.078500149,0.000438579,-1.661570371 +urn:mavedb:00000041-a-1#142,NA,NA,p.Thr191Val,0.633897986,1.3e-22,8.210000000000001e-44,-0.633897986 +urn:mavedb:00000041-a-1#143,NA,NA,p.Thr191Trp,0.862138368,0.339658694,2.78e-17,-0.862138368 +urn:mavedb:00000041-a-1#144,NA,NA,p.Thr191Ter,1.4955361269999998,9.51e-16,2.02e-30,-1.4955361269999998 +urn:mavedb:00000041-a-1#145,NA,NA,p.Thr191Pro,1.591999103,8.65e-17,1.8999999999999998e-32,-1.591999103 +urn:mavedb:00000041-a-1#146,NA,NA,p.Thr191Lys,0.75697873,1.6999999999999999e-19,9.95e-38,-0.75697873 +urn:mavedb:00000041-a-1#147,NA,NA,p.Thr191Ile,0.933102252,4.32e-18,5.56e-35,-0.933102252 +urn:mavedb:00000041-a-1#148,NA,NA,p.Thr191Cys,0.463222495,1.37e-36,3.71e-71,-0.463222495 +urn:mavedb:00000041-a-1#149,NA,NA,p.Thr191Asp,0.622569138,1.55e-31,2.9699999999999995e-61,-0.622569138 +urn:mavedb:00000041-a-1#177,NA,NA,p.Thr163Lys,1.588665898,1.69e-10,2.89e-20,-1.588665898 +urn:mavedb:00000041-a-1#178,NA,NA,p.Thr163Leu,1.5454790669999998,4.3399999999999995e-15,3.88e-29,-1.5454790669999998 +urn:mavedb:00000041-a-1#179,NA,NA,p.Thr163Ile,1.533342089,1.83e-07,1.78e-14,-1.533342089 +urn:mavedb:00000041-a-1#180,NA,NA,p.Thr163His,1.525997876,1.43e-12,2.9399999999999998e-24,-1.525997876 +urn:mavedb:00000041-a-1#181,NA,NA,p.Thr163Gly,1.569221199,6.46e-09,3.11e-17,-1.569221199 +urn:mavedb:00000041-a-1#182,NA,NA,p.Thr163Glu,1.5820456019999998,7.140000000000001e-11,5.520000000000001e-21,-1.5820456019999998 +urn:mavedb:00000041-a-1#183,NA,NA,p.Thr163Gln,1.5893350240000002,2.97e-10,8.529999999999999e-20,-1.5893350240000002 +urn:mavedb:00000041-a-1#184,NA,NA,p.Thr163Cys,1.5641625819999998,1.15e-09,1.15e-18,-1.5641625819999998 +urn:mavedb:00000041-a-1#185,NA,NA,p.Thr163Asp,1.6110522180000002,5.3e-11,3.09e-21,-1.6110522180000002 +urn:mavedb:00000041-a-1#186,NA,NA,p.Thr163Asn,1.527708445,4.37e-14,3.410000000000001e-27,-1.527708445 +urn:mavedb:00000041-a-1#187,NA,NA,p.Thr163Arg,1.592104367,1.22e-12,2.1699999999999997e-24,-1.592104367 +urn:mavedb:00000041-a-1#188,NA,NA,p.Thr163Ala,1.505550724,3.1399999999999995e-10,9.53e-20,-1.505550724 +urn:mavedb:00000041-a-1#189,NA,NA,p.Thr151Ter,1.57287565,0.108773624,0.0008578769999999999,-1.57287565 +urn:mavedb:00000041-a-1#190,NA,NA,p.Thr151Ser,0.464074687,1.5199999999999993e-82,3.019999999999998e-161,-0.464074687 +urn:mavedb:00000041-a-1#191,NA,NA,p.Thr151Pro,1.5521404090000002,8.740000000000002e-10,6.709999999999998e-19,-1.5521404090000002 +urn:mavedb:00000041-a-1#192,NA,NA,p.Thr151Lys,0.944547077,0.175863993,0.00035000699999999994,-0.944547077 +urn:mavedb:00000041-a-1#193,NA,NA,p.Thr151Gly,1.456372166,2.59e-21,2.91e-41,-1.456372166 +urn:mavedb:00000041-a-1#194,NA,NA,p.Thr151Glu,0.701718477,1.6699999999999998e-27,2.26e-53,-0.701718477 +urn:mavedb:00000041-a-1#195,NA,NA,p.Thr151Asp,1.064906606,4.84e-41,7.16e-80,-1.064906606 +urn:mavedb:00000041-a-1#228,NA,NA,p.Ser177Leu,0.912819665,3.59e-27,1.01e-52,-0.912819665 +urn:mavedb:00000041-a-1#229,NA,NA,p.Ser177Ile,0.649940886,3.4599999999999998e-34,1.8899999999999998e-66,-0.649940886 +urn:mavedb:00000041-a-1#230,NA,NA,p.Ser177Arg,1.5767136169999998,2.93e-11,9.83e-22,-1.5767136169999998 +urn:mavedb:00000041-a-1#231,NA,NA,p.Ser106Pro,1.025237578,0.236494819,0.00015852,-1.025237578 +urn:mavedb:00000041-a-1#232,NA,NA,p.Ser79Val,1.457379679,6.54e-14,7.42e-27,-1.457379679 +urn:mavedb:00000041-a-1#233,NA,NA,p.Ser79Tyr,1.554172915,1.53e-08,1.61e-16,-1.554172915 +urn:mavedb:00000041-a-1#234,NA,NA,p.Ser79Thr,1.021478558,2.41e-36,1.1299999999999996e-70,-1.021478558 +urn:mavedb:00000041-a-1#235,NA,NA,p.Ser79Ter,1.582908367,2.23e-10,4.940000000000001e-20,-1.582908367 +urn:mavedb:00000041-a-1#236,NA,NA,p.Ser79Pro,1.1739188,2.26e-13,8.14e-26,-1.1739188 +urn:mavedb:00000041-a-1#237,NA,NA,p.Ser79Phe,1.51252584,9.81e-13,1.3999999999999999e-24,-1.51252584 +urn:mavedb:00000041-a-1#238,NA,NA,p.Ser79Met,1.167627553,9.929999999999993e-116,2.6499999999999976e-226,-1.167627553 +urn:mavedb:00000041-a-1#239,NA,NA,p.Ser79Lys,1.376618687,0.001107389,1e-07,-1.376618687 +urn:mavedb:00000041-a-1#240,NA,NA,p.Ser79Leu,1.5786944790000002,7.31e-11,5.79e-21,-1.5786944790000002 +urn:mavedb:00000041-a-1#241,NA,NA,p.Ser79Ile,1.507056724,3.02e-10,8.789999999999998e-20,-1.507056724 +urn:mavedb:00000041-a-1#242,NA,NA,p.Ser79His,1.204960715,1.26e-15,3.47e-30,-1.204960715 +urn:mavedb:00000041-a-1#243,NA,NA,p.Ser79Gly,1.328368364,1.16e-06,5.7e-13,-1.328368364 +urn:mavedb:00000041-a-1#244,NA,NA,p.Ser79Glu,1.344729474,1.82e-10,3.32e-20,-1.344729474 +urn:mavedb:00000041-a-1#245,NA,NA,p.Ser79Gln,0.807173537,1.82e-35,5.92e-69,-0.807173537 +urn:mavedb:00000041-a-1#246,NA,NA,p.Ser79Arg,1.463736367,2.29e-10,5.19e-20,-1.463736367 +urn:mavedb:00000041-a-1#261,NA,NA,p.Ser64Arg,0.999477663,3.42e-06,4.03e-12,-0.999477663 +urn:mavedb:00000041-a-1#289,NA,NA,p.Pro222Glu,1.1410449459999998,2.55e-11,7.48e-22,-1.1410449459999998 +urn:mavedb:00000041-a-1#290,NA,NA,p.Pro222Gln,0.782190994,1.33e-11,2.1000000000000003e-22,-0.782190994 +urn:mavedb:00000041-a-1#291,NA,NA,p.Pro222Asp,1.3879118469999998,3.06e-08,5.62e-16,-1.3879118469999998 +urn:mavedb:00000041-a-1#292,NA,NA,p.Pro222Asn,1.0595914709999998,2.52e-24,3.8099999999999996e-47,-1.0595914709999998 +urn:mavedb:00000041-a-1#293,NA,NA,p.Pro219Ter,1.627350122,3.72e-08,8.630000000000001e-16,-1.627350122 +urn:mavedb:00000041-a-1#294,NA,NA,p.Pro219Gly,0.98143149,0.000820469,4.36e-08,-0.98143149 +urn:mavedb:00000041-a-1#295,NA,NA,p.Pro218Trp,0.820714954,1.54e-41,7.499999999999996e-81,-0.820714954 +urn:mavedb:00000041-a-1#296,NA,NA,p.Pro218Thr,1.079985127,1.34e-33,2.6499999999999998e-65,-1.079985127 +urn:mavedb:00000041-a-1#297,NA,NA,p.Pro218Phe,0.7884437009999999,3.19e-13,1.54e-25,-0.7884437009999999 +urn:mavedb:00000041-a-1#298,NA,NA,p.Pro218Met,0.622003134,1.5e-12,3.0699999999999998e-24,-0.622003134 +urn:mavedb:00000041-a-1#300,NA,NA,p.Pro218Gly,0.526803299,1.07e-16,2.8e-32,-0.526803299 +urn:mavedb:00000041-a-1#301,NA,NA,p.Pro218Asp,0.6380644560000001,8.24e-32,8.4e-62,-0.6380644560000001 +urn:mavedb:00000041-a-1#302,NA,NA,p.Pro218Asn,0.5713189870000001,3.7499999999999995e-43,5.07e-84,-0.5713189870000001 +urn:mavedb:00000041-a-1#321,NA,NA,p.Pro196Phe,1.550858546,1.14e-11,1.61e-22,-1.550858546 +urn:mavedb:00000041-a-1#322,NA,NA,p.Pro196Met,0.913893608,1.09e-50,8.859999999999994e-99,-0.913893608 +urn:mavedb:00000041-a-1#323,NA,NA,p.Pro196Leu,0.6685999229999999,6.9e-18,1.3499999999999999e-34,-0.6685999229999999 +urn:mavedb:00000041-a-1#324,NA,NA,p.Pro196Ile,0.7588953359999999,1.63e-17,7.19e-34,-0.7588953359999999 +urn:mavedb:00000041-a-1#325,NA,NA,p.Pro196His,1.610011866,2.29e-06,1.97e-12,-1.610011866 +urn:mavedb:00000041-a-1#326,NA,NA,p.Pro196Gly,1.51566567,5.21e-11,3.01e-21,-1.51566567 +urn:mavedb:00000041-a-1#327,NA,NA,p.Pro196Glu,1.6210743630000002,1.78e-08,2.14e-16,-1.6210743630000002 +urn:mavedb:00000041-a-1#328,NA,NA,p.Pro196Gln,1.581568286,2.68e-08,4.650000000000002e-16,-1.581568286 +urn:mavedb:00000041-a-1#329,NA,NA,p.Pro196Cys,1.13784402,2.36e-26,4.1399999999999994e-51,-1.13784402 +urn:mavedb:00000041-a-1#330,NA,NA,p.Pro196Asp,1.54504055,3.75e-11,1.59e-21,-1.54504055 +urn:mavedb:00000041-a-1#331,NA,NA,p.Pro196Asn,1.341023115,1.12e-10,1.32e-20,-1.341023115 +urn:mavedb:00000041-a-1#332,NA,NA,p.Pro196Arg,1.56047656,5.079999999999999e-07,1.22e-13,-1.56047656 +urn:mavedb:00000041-a-1#333,NA,NA,p.Pro196Ala,1.278027793,1.89e-07,1.8000000000000002e-14,-1.278027793 +urn:mavedb:00000041-a-1#345,NA,NA,p.Pro95Ile,0.656799034,0.4536120870000001,2.78e-17,-0.656799034 +urn:mavedb:00000041-a-1#346,NA,NA,p.Pro95His,0.6574929039999999,0.461336562,2.13e-10,-0.6574929039999999 +urn:mavedb:00000041-a-1#347,NA,NA,p.Pro95Glu,0.8237448009999999,1.08e-12,1.62e-24,-0.8237448009999999 +urn:mavedb:00000041-a-1#348,NA,NA,p.Pro95Gln,0.491699191,0.15782231800000002,4.07e-05,-0.491699191 +urn:mavedb:00000041-a-1#349,NA,NA,p.Pro95Cys,0.604541945,1.73e-55,3.3599999999999988e-108,-0.604541945 +urn:mavedb:00000041-a-1#350,NA,NA,p.Pro95Asp,0.967312142,1.49e-23,1.22e-45,-0.967312142 +urn:mavedb:00000041-a-1#351,NA,NA,p.Pro95Asn,0.6055121689999999,1.66e-30,3.009999999999999e-59,-0.6055121689999999 +urn:mavedb:00000041-a-1#352,NA,NA,p.Pro67Thr,1.337117263,6.9e-19,1.54e-36,-1.337117263 +urn:mavedb:00000041-a-1#353,NA,NA,p.Pro67Ter,1.421570629,4.13e-10,1.6199999999999999e-19,-1.421570629 +urn:mavedb:00000041-a-1#354,NA,NA,p.Pro67Ser,1.207925188,8.85e-14,1.32e-26,-1.207925188 +urn:mavedb:00000041-a-1#355,NA,NA,p.Pro67Met,1.405179019,1.21e-28,1.37e-55,-1.405179019 +urn:mavedb:00000041-a-1#356,NA,NA,p.Pro67Lys,0.8842482770000001,3.3299999999999997e-40,3.0999999999999997e-78,-0.8842482770000001 +urn:mavedb:00000041-a-1#357,NA,NA,p.Pro67Ile,1.286370761,2.52e-13,1e-25,-1.286370761 +urn:mavedb:00000041-a-1#358,NA,NA,p.Pro67Gln,1.1095324640000002,2.8899999999999998e-27,6.69e-53,-1.1095324640000002 +urn:mavedb:00000041-a-1#359,NA,NA,p.Pro67Asn,1.057615335,4.030000000000001e-24,9.29e-47,-1.057615335 +urn:mavedb:00000041-a-1#360,NA,NA,p.Pro67Arg,1.069330831,3.96e-44,6.259999999999997e-86,-1.069330831 +urn:mavedb:00000041-a-1#361,NA,NA,p.Pro38Ter,1.6314669240000002,4.61e-10,2e-19,-1.6314669240000002 +urn:mavedb:00000041-a-1#362,NA,NA,p.Pro38Leu,0.551365605,1.18e-16,3.379999999999999e-32,-0.551365605 +urn:mavedb:00000041-a-1#363,NA,NA,p.Pro33Ter,1.646708497,4.28e-05,4.26e-10,-1.646708497 +urn:mavedb:00000041-a-1#364,NA,NA,p.Pro33Cys,0.5041556189999999,1.1599999999999998e-37,2.9399999999999995e-73,-0.5041556189999999 +urn:mavedb:00000041-a-1#365,NA,NA,p.Phe249Val,0.646993306,1.56e-08,1.54e-16,-0.646993306 +urn:mavedb:00000041-a-1#366,NA,NA,p.Phe249Ter,1.725919903,1.2e-06,6.04e-13,-1.725919903 +urn:mavedb:00000041-a-1#367,NA,NA,p.Phe249Ser,0.70460414,9.44e-16,1.94e-30,-0.70460414 +urn:mavedb:00000041-a-1#368,NA,NA,p.Phe249Pro,0.8282841329999999,1.38e-19,6.76e-38,-0.8282841329999999 +urn:mavedb:00000041-a-1#369,NA,NA,p.Phe249Met,0.638939418,2.18e-19,1.6399999999999995e-37,-0.638939418 +urn:mavedb:00000041-a-1#381,NA,NA,p.Phe243Asp,1.4609255280000002,5.44e-11,3.2500000000000003e-21,-1.4609255280000002 +urn:mavedb:00000041-a-1#382,NA,NA,p.Phe243Arg,1.550667086,1.12e-08,8.859999999999999e-17,-1.550667086 +urn:mavedb:00000041-a-1#383,NA,NA,p.Phe182Val,0.695732624,3.5700000000000003e-11,1.4000000000000002e-21,-0.695732624 +urn:mavedb:00000041-a-1#384,NA,NA,p.Phe182Thr,1.457594801,3.39e-06,4.14e-12,-1.457594801 +urn:mavedb:00000041-a-1#385,NA,NA,p.Phe182Ter,1.6003672409999998,1.53e-08,1.6e-16,-1.6003672409999998 +urn:mavedb:00000041-a-1#386,NA,NA,p.Phe182Ser,1.50962249,4.74e-06,7.61e-12,-1.50962249 +urn:mavedb:00000041-a-1#390,NA,NA,p.Phe182Gly,1.562651979,9.49e-06,2.7600000000000007e-11,-1.562651979 +urn:mavedb:00000041-a-1#391,NA,NA,p.Phe182Glu,1.555011711,0.000120793,2.64e-09,-1.555011711 +urn:mavedb:00000041-a-1#392,NA,NA,p.Phe182Gln,1.506313913,2.35e-10,5.44e-20,-1.506313913 +urn:mavedb:00000041-a-1#393,NA,NA,p.Phe182Cys,0.566166295,0.101811269,2.25e-11,-0.566166295 +urn:mavedb:00000041-a-1#394,NA,NA,p.Phe182Asp,1.5092537190000002,1.16e-15,2.99e-30,-1.5092537190000002 +urn:mavedb:00000041-a-1#412,NA,NA,p.Val209Asn,0.7893772929999999,1.0699999999999995e-70,5.199999999999997e-138,-0.7893772929999999 +urn:mavedb:00000041-a-1#413,NA,NA,p.Val209Arg,1.464650753,3.13e-12,1.33e-23,-1.464650753 +urn:mavedb:00000041-a-1#414,NA,NA,p.Val201Ter,1.439376521,2.69e-10,7.05e-20,-1.439376521 +urn:mavedb:00000041-a-1#415,NA,NA,p.Val201Pro,0.956793596,4.02e-07,7.46e-14,-0.956793596 +urn:mavedb:00000041-a-1#416,NA,NA,p.Val201Lys,0.486071856,7.45e-18,1.58e-34,-0.486071856 +urn:mavedb:00000041-a-1#2319,NA,NA,p.Leu92His,0.259084018,0.423406394,1.39e-16,-0.259084018 +urn:mavedb:00000041-a-1#417,NA,NA,p.Val179Phe,1.554919617,2.33e-15,1.1599999999999997e-29,-1.554919617 +urn:mavedb:00000041-a-1#418,NA,NA,p.Val179Leu,0.470484679,1.4899999999999998e-20,8.45e-40,-0.470484679 +urn:mavedb:00000041-a-1#419,NA,NA,p.Val136Tyr,1.543379304,7.08e-10,4.49e-19,-1.543379304 +urn:mavedb:00000041-a-1#420,NA,NA,p.Val136Thr,1.047040521,1.26e-17,4.3799999999999984e-34,-1.047040521 +urn:mavedb:00000041-a-1#421,NA,NA,p.Val136Ser,1.4242912980000002,1.1e-12,1.74e-24,-1.4242912980000002 +urn:mavedb:00000041-a-1#422,NA,NA,p.Val136Pro,1.498650206,2.84e-15,1.69e-29,-1.498650206 +urn:mavedb:00000041-a-1#423,NA,NA,p.Val136Phe,1.817233167,0.257968432,0.000359951,-1.817233167 +urn:mavedb:00000041-a-1#424,NA,NA,p.Val136Met,1.06827215,3.39e-26,8.379999999999997e-51,-1.06827215 +urn:mavedb:00000041-a-1#425,NA,NA,p.Val136Lys,1.946372968,0.572473543,4.39e-15,-1.946372968 +urn:mavedb:00000041-a-1#440,NA,NA,p.Val128Ter,1.660105919,0.059401663,0.000232299,-1.660105919 +urn:mavedb:00000041-a-1#441,NA,NA,p.Val128Ser,1.215759451,0.081425096,0.0004798580000000001,-1.215759451 +urn:mavedb:00000041-a-1#442,NA,NA,p.Val128Pro,1.536946705,2.07e-12,5.96e-24,-1.536946705 +urn:mavedb:00000041-a-1#443,NA,NA,p.Val128Phe,1.171437528,1.01e-15,2.24e-30,-1.171437528 +urn:mavedb:00000041-a-1#444,NA,NA,p.Val128Met,1.212042162,8.409999999999997e-15,1.38e-28,-1.212042162 +urn:mavedb:00000041-a-1#2469,NA,NA,p.Glu238Cys,-0.781965335,7.38e-29,5.31e-56,0.781965335 +urn:mavedb:00000041-a-1#445,NA,NA,p.Val128Lys,0.994487311,1.2799999999999998e-29,1.6800000000000002e-57,-0.994487311 +urn:mavedb:00000041-a-1#446,NA,NA,p.Val128Leu,0.73772863,2.8000000000000005e-17,2.12e-33,-0.73772863 +urn:mavedb:00000041-a-1#447,NA,NA,p.Val128Ile,0.490956018,1.7500000000000002e-26,2.21e-51,-0.490956018 +urn:mavedb:00000041-a-1#448,NA,NA,p.Val128His,1.273135938,6.819999999999999e-10,4.1799999999999996e-19,-1.273135938 +urn:mavedb:00000041-a-1#449,NA,NA,p.Val128Gly,1.197281354,0.000442657,2.36e-08,-1.197281354 +urn:mavedb:00000041-a-1#450,NA,NA,p.Val128Cys,0.57066839,1.34e-06,6.59e-13,-0.57066839 +urn:mavedb:00000041-a-1#451,NA,NA,p.Val128Asp,1.540504,0.247846985,0.0007364369999999999,-1.540504 +urn:mavedb:00000041-a-1#474,NA,NA,p.Val111Ser,1.330713993,4.93e-18,7.209999999999998e-35,-1.330713993 +urn:mavedb:00000041-a-1#475,NA,NA,p.Val111Pro,1.572316501,2.22e-09,4.03e-18,-1.572316501 +urn:mavedb:00000041-a-1#476,NA,NA,p.Val111Leu,1.310947962,1.81e-18,1.0199999999999998e-35,-1.310947962 +urn:mavedb:00000041-a-1#477,NA,NA,p.Val111His,0.81183673,4.44e-07,9.12e-14,-0.81183673 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+urn:mavedb:00000041-a-1#487,NA,NA,p.Val98Glu,0.775384362,6.7e-25,2.83e-48,-0.775384362 +urn:mavedb:00000041-a-1#488,NA,NA,p.Val98Gln,0.476344056,6.16e-07,1.57e-13,-0.476344056 +urn:mavedb:00000041-a-1#489,NA,NA,p.Val98Asp,1.268025175,8.44e-18,2.05e-34,-1.268025175 +urn:mavedb:00000041-a-1#490,NA,NA,p.Val71Tyr,1.612192167,1.1100000000000002e-08,8.8e-17,-1.612192167 +urn:mavedb:00000041-a-1#491,NA,NA,p.Val71Trp,1.541447122,3.0699999999999998e-15,1.96e-29,-1.541447122 +urn:mavedb:00000041-a-1#492,NA,NA,p.Val71Ter,1.590644921,3.49e-10,1.17e-19,-1.590644921 +urn:mavedb:00000041-a-1#493,NA,NA,p.Val71Ser,1.235110247,3.5700000000000007e-09,9.83e-18,-1.235110247 +urn:mavedb:00000041-a-1#494,NA,NA,p.Val71Pro,1.604370803,0.00026334,1.03e-08,-1.604370803 +urn:mavedb:00000041-a-1#495,NA,NA,p.Val71Phe,1.556093639,0.004838857,5.64e-07,-1.556093639 +urn:mavedb:00000041-a-1#496,NA,NA,p.Val71Met,0.7058820309999999,1.24e-08,9.98e-17,-0.7058820309999999 +urn:mavedb:00000041-a-1#497,NA,NA,p.Val71Lys,1.6210378680000002,2.01e-07,2.1e-14,-1.6210378680000002 +urn:mavedb:00000041-a-1#498,NA,NA,p.Val71Leu,0.806194848,1.7800000000000002e-33,4.66e-65,-0.806194848 +urn:mavedb:00000041-a-1#499,NA,NA,p.Val71His,1.541909331,1.19e-14,2.7500000000000003e-28,-1.541909331 +urn:mavedb:00000041-a-1#500,NA,NA,p.Val71Gly,1.341360774,0.000881057,6.99e-08,-1.341360774 +urn:mavedb:00000041-a-1#501,NA,NA,p.Val71Glu,1.527795398,4.94e-16,5.66e-31,-1.527795398 +urn:mavedb:00000041-a-1#502,NA,NA,p.Val71Gln,1.56281014,6.32e-08,2.36e-15,-1.56281014 +urn:mavedb:00000041-a-1#503,NA,NA,p.Val71Asp,1.672691367,1.64e-07,1.43e-14,-1.672691367 +urn:mavedb:00000041-a-1#504,NA,NA,p.Val71Asn,1.4411199019999998,0.011368946,1.71e-06,-1.4411199019999998 +urn:mavedb:00000041-a-1#505,NA,NA,p.Val71Arg,1.547303038,3.4e-13,1.82e-25,-1.547303038 +urn:mavedb:00000041-a-1#506,NA,NA,p.Val63Thr,0.920580515,3.82e-40,4.0499999999999977e-78,-0.920580515 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+urn:mavedb:00000041-a-1#515,NA,NA,p.Val62Pro,1.6290086869999998,0.000343657,1.62e-08,-1.6290086869999998 +urn:mavedb:00000041-a-1#516,NA,NA,p.Val62Ile,1.150345564,0.653487547,0.0,-1.150345564 +urn:mavedb:00000041-a-1#517,NA,NA,p.Val62His,0.871144791,5.17e-18,7.919999999999998e-35,-0.871144791 +urn:mavedb:00000041-a-1#518,NA,NA,p.Val62Gly,1.221896031,1.4499999999999996e-29,2.17e-57,-1.221896031 +urn:mavedb:00000041-a-1#519,NA,NA,p.Val62Asp,0.7777884359999999,1.87e-16,8.550000000000001e-32,-0.7777884359999999 +urn:mavedb:00000041-a-1#520,NA,NA,p.Val62Arg,0.666538472,4.4499999999999995e-29,1.8499999999999997e-56,-0.666538472 +urn:mavedb:00000041-a-1#521,NA,NA,p.Val57Pro,0.968712889,3.419999999999999e-81,1.3799999999999992e-158,-0.968712889 +urn:mavedb:00000041-a-1#522,NA,NA,p.Val57Phe,0.620207825,0.076159264,2.48e-07,-0.620207825 +urn:mavedb:00000041-a-1#465,NA,NA,p.Val117Gly,1.458622541,6.96e-05,9.76e-10,-1.458622541 +urn:mavedb:00000041-a-1#466,NA,NA,p.Val117Glu,1.622841693,9.81e-06,2.9e-11,-1.622841693 +urn:mavedb:00000041-a-1#467,NA,NA,p.Val117Gln,1.642681408,7.45e-15,1.1e-28,-1.642681408 +urn:mavedb:00000041-a-1#468,NA,NA,p.Val117Asp,1.753252304,5.09e-05,5.820000000000001e-10,-1.753252304 +urn:mavedb:00000041-a-1#469,NA,NA,p.Val117Arg,1.700506097,0.285409329,3.76e-05,-1.700506097 +urn:mavedb:00000041-a-1#470,NA,NA,p.Val117Ala,1.130847087,5.25e-12,3.53e-23,-1.130847087 +urn:mavedb:00000041-a-1#471,NA,NA,p.Val111Tyr,1.6105848530000002,0.408393892,4.11e-09,-1.6105848530000002 +urn:mavedb:00000041-a-1#472,NA,NA,p.Val111Thr,0.836201785,3.68e-21,5.579999999999999e-41,-0.836201785 +urn:mavedb:00000041-a-1#473,NA,NA,p.Val111Ter,1.6422292630000002,1.04e-09,9.35e-19,-1.6422292630000002 +urn:mavedb:00000041-a-1#595,NA,NA,p.Met108Asp,1.6569418530000002,0.003524531,3.770000000000001e-07,-1.6569418530000002 +urn:mavedb:00000041-a-1#596,NA,NA,p.Met108Arg,1.550844652,1.56e-13,4.02e-26,-1.550844652 +urn:mavedb:00000041-a-1#597,NA,NA,p.Met100Ter,1.680086468,6.12e-07,1.7199999999999992e-13,-1.680086468 +urn:mavedb:00000041-a-1#598,NA,NA,p.Met100Pro,1.4390987990000002,0.025114621,2.59e-05,-1.4390987990000002 +urn:mavedb:00000041-a-1#599,NA,NA,p.Met100Arg,1.10712812,9.549999999999999e-64,2.1699999999999996e-124,-1.10712812 +urn:mavedb:00000041-a-1#600,NA,NA,p.Met75Tyr,0.667031931,3.289999999999999e-38,2.4699999999999993e-74,-0.667031931 +urn:mavedb:00000041-a-1#601,NA,NA,p.Met75Trp,1.737964483,8.820000000000002e-10,6.809999999999999e-19,-1.737964483 +urn:mavedb:00000041-a-1#602,NA,NA,p.Met75Thr,1.334920877,7.400000000000001e-10,4.79e-19,-1.334920877 +urn:mavedb:00000041-a-1#2687,NA,NA,p.Glu149Ala,-0.393933299,3.52e-14,2.22e-27,0.393933299 +urn:mavedb:00000041-a-1#603,NA,NA,p.Met75Ser,0.877293007,2.8199999999999996e-78,7.149999999999997e-153,-0.877293007 +urn:mavedb:00000041-a-1#604,NA,NA,p.Met75Pro,1.62147439,2.22e-13,7.969999999999998e-26,-1.62147439 +urn:mavedb:00000041-a-1#605,NA,NA,p.Met75Leu,0.875477153,2.7600000000000004e-27,6.029999999999998e-53,-0.875477153 +urn:mavedb:00000041-a-1#606,NA,NA,p.Met75Ile,0.7542300559999999,4.99e-24,1.3999999999999997e-46,-0.7542300559999999 +urn:mavedb:00000041-a-1#607,NA,NA,p.Met75Gly,1.076243885,2.85e-82,1.0499999999999992e-160,-1.076243885 +urn:mavedb:00000041-a-1#608,NA,NA,p.Met75Glu,0.494881915,0.114158088,2.03e-09,-0.494881915 +urn:mavedb:00000041-a-1#609,NA,NA,p.Met75Asp,1.2423106309999998,1.04e-24,6.74e-48,-1.2423106309999998 +urn:mavedb:00000041-a-1#610,NA,NA,p.Met75Asn,0.982066808,1.7499999999999993e-49,1.99e-96,-0.982066808 +urn:mavedb:00000041-a-1#611,NA,NA,p.Met48Val,1.6080752230000002,3.77e-08,8.88e-16,-1.6080752230000002 +urn:mavedb:00000041-a-1#612,NA,NA,p.Met48Tyr,1.351531554,3.4e-08,7.22e-16,-1.351531554 +urn:mavedb:00000041-a-1#613,NA,NA,p.Met48Trp,1.6237784169999998,5.08e-21,1.09e-40,-1.6237784169999998 +urn:mavedb:00000041-a-1#614,NA,NA,p.Met48Thr,1.524513444,2.21e-07,2.52e-14,-1.524513444 +urn:mavedb:00000041-a-1#615,NA,NA,p.Met48Ter,1.6581907130000002,2.87e-10,8.029999999999998e-20,-1.6581907130000002 +urn:mavedb:00000041-a-1#616,NA,NA,p.Met48Ser,1.166773128,3.86e-05,3.46e-10,-1.166773128 +urn:mavedb:00000041-a-1#617,NA,NA,p.Met48Pro,1.448742477,1.46e-10,2.19e-20,-1.448742477 +urn:mavedb:00000041-a-1#618,NA,NA,p.Met48Phe,1.534294186,1.31e-07,9.49e-15,-1.534294186 +urn:mavedb:00000041-a-1#619,NA,NA,p.Met48Lys,1.605228796,2.67e-14,1.31e-27,-1.605228796 +urn:mavedb:00000041-a-1#620,NA,NA,p.Met48Leu,0.47948261,3.09e-12,1.24e-23,-0.47948261 +urn:mavedb:00000041-a-1#2688,NA,NA,p.Glu146Pro,-0.025162999,2.47e-21,2.5399999999999996e-41,0.025162999 +urn:mavedb:00000041-a-1#621,NA,NA,p.Met48Ile,1.741674963,0.255989126,0.000241478,-1.741674963 +urn:mavedb:00000041-a-1#622,NA,NA,p.Met48His,0.6084305870000001,2.16e-11,5.360000000000002e-22,-0.6084305870000001 +urn:mavedb:00000041-a-1#623,NA,NA,p.Met48Gly,1.017286242,1.79e-08,2.1099999999999998e-16,-1.017286242 +urn:mavedb:00000041-a-1#2749,NA,NA,p.Glu39Phe,-0.250391922,1.98e-07,1.93e-14,0.250391922 +urn:mavedb:00000041-a-1#624,NA,NA,p.Met48Gln,1.392699921,1.57e-05,6.820000000000001e-11,-1.392699921 +urn:mavedb:00000041-a-1#625,NA,NA,p.Met48Cys,1.131939019,0.000267684,1.03e-08,-1.131939019 +urn:mavedb:00000041-a-1#626,NA,NA,p.Met48Asp,1.55969179,5.6600000000000014e-05,7.01e-10,-1.55969179 +urn:mavedb:00000041-a-1#627,NA,NA,p.Met48Asn,0.996816458,7.7e-09,4.32e-17,-0.996816458 +urn:mavedb:00000041-a-1#628,NA,NA,p.Met48Arg,1.530304249,7.940000000000001e-16,1.4299999999999999e-30,-1.530304249 +urn:mavedb:00000041-a-1#629,NA,NA,p.Met48Ala,1.422171715,1.86e-09,2.85e-18,-1.422171715 +urn:mavedb:00000041-a-1#630,NA,NA,p.Met36Thr,1.471547465,0.390519734,8.400000000000001e-14,-1.471547465 +urn:mavedb:00000041-a-1#631,NA,NA,p.Met36Pro,1.406725318,5.64e-10,2.8899999999999996e-19,-1.406725318 +urn:mavedb:00000041-a-1#632,NA,NA,p.Met36Phe,1.552924631,3.68e-10,1.2900000000000002e-19,-1.552924631 +urn:mavedb:00000041-a-1#633,NA,NA,p.Met36Leu,1.399531592,6.04e-09,2.7e-17,-1.399531592 +urn:mavedb:00000041-a-1#634,NA,NA,p.Met36Glu,0.521250028,1.58e-51,1.959999999999999e-100,-0.521250028 +urn:mavedb:00000041-a-1#635,NA,NA,p.Met17Val,0.592787707,2.05e-17,1.14e-33,-0.592787707 +urn:mavedb:00000041-a-1#636,NA,NA,p.Met17Thr,0.529669335,7.629999999999997e-100,3.609999999999998e-195,-0.529669335 +urn:mavedb:00000041-a-1#637,NA,NA,p.Met17Ter,1.62318096,2.7600000000000007e-05,1.94e-10,-1.62318096 +urn:mavedb:00000041-a-1#638,NA,NA,p.Met17Pro,1.466014729,3.05e-06,3.4400000000000007e-12,-1.466014729 +urn:mavedb:00000041-a-1#639,NA,NA,p.Met17Ile,0.502951258,2.4e-25,3.65e-49,-0.502951258 +urn:mavedb:00000041-a-1#640,NA,NA,p.Lys235Trp,0.5870986999999999,0.222966165,9.37e-07,-0.5870986999999999 +urn:mavedb:00000041-a-1#641,NA,NA,p.Lys235Leu,0.557518337,4.9399999999999995e-43,8.779999999999994e-84,-0.557518337 +urn:mavedb:00000041-a-1#642,NA,NA,p.Lys192Val,0.471952224,2.67e-24,4.25e-47,-0.471952224 +urn:mavedb:00000041-a-1#643,NA,NA,p.Lys192His,0.567349409,0.29644231600000004,2.78e-17,-0.567349409 +urn:mavedb:00000041-a-1#644,NA,NA,p.Lys192Arg,0.508882122,6.1700000000000006e-12,4.55e-23,-0.508882122 +urn:mavedb:00000041-a-1#645,NA,NA,p.Lys176Ter,1.5264509730000002,5.63e-08,1.92e-15,-1.5264509730000002 +urn:mavedb:00000041-a-1#646,NA,NA,p.Lys176Ile,0.991751381,1.1799999999999999e-20,5.54e-40,-0.991751381 +urn:mavedb:00000041-a-1#647,NA,NA,p.Lys161Tyr,1.50384649,1.44e-10,2.11e-20,-1.50384649 +urn:mavedb:00000041-a-1#648,NA,NA,p.Lys161Trp,1.635290797,1.3000000000000002e-10,1.7699999999999998e-20,-1.635290797 +urn:mavedb:00000041-a-1#649,NA,NA,p.Lys161Phe,1.578768001,0.004410377,5.67e-07,-1.578768001 +urn:mavedb:00000041-a-1#650,NA,NA,p.Lys161His,1.7041743230000002,5.57e-06,1.07e-11,-1.7041743230000002 +urn:mavedb:00000041-a-1#651,NA,NA,p.Lys161Gly,1.614071021,0.20643812600000006,0.001585105,-1.614071021 +urn:mavedb:00000041-a-1#652,NA,NA,p.Lys161Gln,1.64495115,8.05e-05,1.35e-09,-1.64495115 +urn:mavedb:00000041-a-1#653,NA,NA,p.Lys161Asp,1.530001882,3.32e-09,8.67e-18,-1.530001882 +urn:mavedb:00000041-a-1#654,NA,NA,p.Lys161Asn,1.268210819,1.1e-11,1.5e-22,-1.268210819 +urn:mavedb:00000041-a-1#655,NA,NA,p.Lys161Arg,0.7369268179999999,3.64e-30,1.41e-58,-0.7369268179999999 +urn:mavedb:00000041-a-1#656,NA,NA,p.Lys161Ala,0.996761983,6.06e-19,1.1999999999999997e-36,-0.996761983 +urn:mavedb:00000041-a-1#657,NA,NA,p.Lys157Tyr,1.54313877,2.59e-50,4.6999999999999994e-98,-1.54313877 +urn:mavedb:00000041-a-1#658,NA,NA,p.Lys157Thr,0.610895368,8.02e-15,1.22e-28,-0.610895368 +urn:mavedb:00000041-a-1#659,NA,NA,p.Lys157Ter,1.654122588,3.18e-21,4.35e-41,-1.654122588 +urn:mavedb:00000041-a-1#660,NA,NA,p.Lys157Ser,1.133077949,1.63e-08,1.78e-16,-1.133077949 +urn:mavedb:00000041-a-1#661,NA,NA,p.Lys157His,0.513403325,9.17e-30,8.6e-58,-0.513403325 +urn:mavedb:00000041-a-1#662,NA,NA,p.Lys157Gly,1.363242923,3.07e-19,3.2200000000000003e-37,-1.363242923 +urn:mavedb:00000041-a-1#663,NA,NA,p.Lys157Asp,1.562913914,6.57e-07,1.94e-13,-1.562913914 +urn:mavedb:00000041-a-1#664,NA,NA,p.Lys157Asn,0.990950341,0.388659674,5.49e-08,-0.990950341 +urn:mavedb:00000041-a-1#665,NA,NA,p.Lys157Ala,0.501547723,7.56e-12,6.76e-23,-0.501547723 +urn:mavedb:00000041-a-1#666,NA,NA,p.Lys135Pro,1.5049093080000002,3.15e-07,4.91e-14,-1.5049093080000002 +urn:mavedb:00000041-a-1#667,NA,NA,p.Lys135Met,0.463484375,8.95e-37,1.61e-71,-0.463484375 +urn:mavedb:00000041-a-1#668,NA,NA,p.Lys135Gly,1.409234124,0.177095759,0.000399851,-1.409234124 +urn:mavedb:00000041-a-1#669,NA,NA,p.Lys135Asp,1.465284964,0.271280875,4.29e-05,-1.465284964 +urn:mavedb:00000041-a-1#670,NA,NA,p.Lys85Ter,1.583056316,2.15e-08,3.05e-16,-1.583056316 +urn:mavedb:00000041-a-1#671,NA,NA,p.Lys85Ser,0.513278392,0.482143617,1.11e-16,-0.513278392 +urn:mavedb:00000041-a-1#672,NA,NA,p.Lys85Pro,0.478538611,0.15528355900000002,2.37e-09,-0.478538611 +urn:mavedb:00000041-a-1#673,NA,NA,p.Lys55Val,0.5659345410000001,3.12e-23,5.0199999999999986e-45,-0.5659345410000001 +urn:mavedb:00000041-a-1#674,NA,NA,p.Lys55Pro,0.918438427,4.02e-29,1.5699999999999997e-56,-0.918438427 +urn:mavedb:00000041-a-1#2780,NA,NA,p.Gln231Gly,-0.116371211,0.000332269,7.74e-09,0.116371211 +urn:mavedb:00000041-a-1#675,NA,NA,p.Lys55Ile,0.750621216,2.3500000000000003e-28,4.9399999999999985e-55,-0.750621216 +urn:mavedb:00000041-a-1#676,NA,NA,p.Lys50Trp,0.927076339,1.95e-29,3.81e-57,-0.927076339 +urn:mavedb:00000041-a-1#677,NA,NA,p.Lys50Gly,0.489475258,2.91e-24,4.88e-47,-0.489475258 +urn:mavedb:00000041-a-1#678,NA,NA,p.Lys49Val,1.356425113,6.87e-06,1.51e-11,-1.356425113 +urn:mavedb:00000041-a-1#679,NA,NA,p.Lys49Tyr,1.3243264,0.000127738,2.93e-09,-1.3243264 +urn:mavedb:00000041-a-1#680,NA,NA,p.Lys49Trp,1.334006656,2.43e-11,6.9299999999999985e-22,-1.334006656 +urn:mavedb:00000041-a-1#681,NA,NA,p.Lys49Thr,0.6966860029999999,9.87e-12,1.15e-22,-0.6966860029999999 +urn:mavedb:00000041-a-1#682,NA,NA,p.Lys49Ter,1.6022041669999998,5.700000000000001e-14,5.66e-27,-1.6022041669999998 +urn:mavedb:00000041-a-1#683,NA,NA,p.Lys49Ser,0.7235695459999999,1.4400000000000002e-13,3.3300000000000003e-26,-0.7235695459999999 +urn:mavedb:00000041-a-1#684,NA,NA,p.Lys49Pro,1.48416398,1.7600000000000002e-17,8.59e-34,-1.48416398 +urn:mavedb:00000041-a-1#685,NA,NA,p.Lys49Phe,1.501156759,0.000305677,1.31e-08,-1.501156759 +urn:mavedb:00000041-a-1#686,NA,NA,p.Lys49Leu,1.4798161019999998,2.27e-07,2.67e-14,-1.4798161019999998 +urn:mavedb:00000041-a-1#687,NA,NA,p.Lys49Ile,1.304250063,4.47e-11,2.22e-21,-1.304250063 +urn:mavedb:00000041-a-1#688,NA,NA,p.Lys49His,1.340330417,2.15e-08,3.0800000000000003e-16,-1.340330417 +urn:mavedb:00000041-a-1#689,NA,NA,p.Lys49Gly,0.889864703,7.41e-11,5.77e-21,-0.889864703 +urn:mavedb:00000041-a-1#2781,NA,NA,p.Gln231Glu,-0.065165764,0.18749689,0.0,0.065165764 +urn:mavedb:00000041-a-1#690,NA,NA,p.Lys49Glu,0.869346497,9.76e-66,2.7899999999999977e-128,-0.869346497 +urn:mavedb:00000041-a-1#691,NA,NA,p.Lys49Gln,0.688974352,0.116220784,0.00081533,-0.688974352 +urn:mavedb:00000041-a-1#692,NA,NA,p.Lys49Cys,1.219240187,5.74e-08,1.9800000000000002e-15,-1.219240187 +urn:mavedb:00000041-a-1#693,NA,NA,p.Lys49Asp,0.490748677,0.387874875,0.0,-0.490748677 +urn:mavedb:00000041-a-1#694,NA,NA,p.Lys49Asn,1.141747745,1.7199999999999998e-05,7.820000000000001e-11,-1.141747745 +urn:mavedb:00000041-a-1#695,NA,NA,p.Lys49Arg,1.470102675,3.2100000000000003e-07,5.03e-14,-1.470102675 +urn:mavedb:00000041-a-1#696,NA,NA,p.Lys49Ala,0.937642608,1.1400000000000002e-29,1.34e-57,-0.937642608 +urn:mavedb:00000041-a-1#697,NA,NA,p.Lys32Tyr,1.462955106,8.77e-10,6.809999999999999e-19,-1.462955106 +urn:mavedb:00000041-a-1#698,NA,NA,p.Lys32Trp,1.4902312169999998,2.48e-08,3.99e-16,-1.4902312169999998 +urn:mavedb:00000041-a-1#699,NA,NA,p.Lys32Thr,1.310258037,1.19e-10,1.45e-20,-1.310258037 +urn:mavedb:00000041-a-1#700,NA,NA,p.Lys32Ter,1.654421343,2.01e-13,6.569999999999999e-26,-1.654421343 +urn:mavedb:00000041-a-1#701,NA,NA,p.Lys32Ser,1.326612055,3.87e-16,3.529999999999999e-31,-1.326612055 +urn:mavedb:00000041-a-1#702,NA,NA,p.Lys32Pro,1.549265827,2.58e-14,1.23e-27,-1.549265827 +urn:mavedb:00000041-a-1#703,NA,NA,p.Lys32Phe,1.564746089,0.000429172,2.25e-08,-1.564746089 +urn:mavedb:00000041-a-1#704,NA,NA,p.Lys32Met,0.628638658,0.398891088,0.0,-0.628638658 +urn:mavedb:00000041-a-1#705,NA,NA,p.Lys32Leu,0.58230862,0.2693206,0.0,-0.58230862 +urn:mavedb:00000041-a-1#706,NA,NA,p.Lys32His,1.5250494630000002,4.24e-06,6.31e-12,-1.5250494630000002 +urn:mavedb:00000041-a-1#707,NA,NA,p.Lys32Gly,1.388852396,2.3199999999999997e-16,1.3099999999999998e-31,-1.388852396 +urn:mavedb:00000041-a-1#708,NA,NA,p.Lys32Glu,1.577704258,2.48e-09,4.99e-18,-1.577704258 +urn:mavedb:00000041-a-1#549,NA,NA,p.Val15Ser,1.4671142169999998,0.008871881,1.4599999999999998e-07,-1.4671142169999998 +urn:mavedb:00000041-a-1#550,NA,NA,p.Val15Pro,1.482409198,6.9e-23,2.4499999999999996e-44,-1.482409198 +urn:mavedb:00000041-a-1#551,NA,NA,p.Val15Met,1.39644165,1.08e-08,8.32e-17,-1.39644165 +urn:mavedb:00000041-a-1#552,NA,NA,p.Val15Lys,1.619053894,1.14e-08,9.17e-17,-1.619053894 +urn:mavedb:00000041-a-1#553,NA,NA,p.Val15Leu,1.5729392969999998,2.11e-12,6.190000000000001e-24,-1.5729392969999998 +urn:mavedb:00000041-a-1#554,NA,NA,p.Val15Ile,1.165305644,1.4699999999999995e-74,1.409999999999999e-145,-1.165305644 +urn:mavedb:00000041-a-1#555,NA,NA,p.Phe173His,1.30847228,5.500000000000001e-20,1.12e-38,-1.30847228 +urn:mavedb:00000041-a-1#556,NA,NA,p.Phe173Gly,1.414722351,3.02e-08,5.82e-16,-1.414722351 +urn:mavedb:00000041-a-1#557,NA,NA,p.Phe173Glu,1.613988093,1.32e-12,2.4900000000000003e-24,-1.613988093 +urn:mavedb:00000041-a-1#558,NA,NA,p.Phe173Gln,1.7509145380000002,6.74e-18,1.32e-34,-1.7509145380000002 +urn:mavedb:00000041-a-1#559,NA,NA,p.Phe173Asp,1.433062967,7.88e-19,2.03e-36,-1.433062967 +urn:mavedb:00000041-a-1#560,NA,NA,p.Phe173Arg,1.7977918380000002,0.003947203,3.9e-07,-1.7977918380000002 +urn:mavedb:00000041-a-1#561,NA,NA,p.Phe173Ala,1.298950454,9.19e-15,1.6299999999999993e-28,-1.298950454 +urn:mavedb:00000041-a-1#562,NA,NA,p.Phe158Val,0.988818897,1.0499999999999999e-21,4.979999999999999e-42,-0.988818897 +urn:mavedb:00000041-a-1#563,NA,NA,p.Phe158Tyr,1.532473434,9.9e-11,1.03e-20,-1.532473434 +urn:mavedb:00000041-a-1#564,NA,NA,p.Phe158Trp,1.251635673,1.74e-25,2.03e-49,-1.251635673 +urn:mavedb:00000041-a-1#2652,NA,NA,p.Leu31Thr,0.191314394,0.075478618,2.27e-08,-0.191314394 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+urn:mavedb:00000041-a-1#787,NA,NA,p.Leu186Pro,1.5906071330000002,2.77e-09,6.15e-18,-1.5906071330000002 +urn:mavedb:00000041-a-1#788,NA,NA,p.Leu186Met,0.562969246,0.303699624,1.39e-17,-0.562969246 +urn:mavedb:00000041-a-1#796,NA,NA,p.Leu186Arg,1.582796184,3.76e-07,6.88e-14,-1.582796184 +urn:mavedb:00000041-a-1#797,NA,NA,p.Leu185Thr,1.064420955,9.14e-05,1.46e-09,-1.064420955 +urn:mavedb:00000041-a-1#798,NA,NA,p.Leu185Ter,1.6679805580000002,0.066457275,0.00030394,-1.6679805580000002 +urn:mavedb:00000041-a-1#3004,NA,NA,p.Pro33Gly,-0.076996603,0.503700587,1.11e-16,0.076996603 +urn:mavedb:00000041-a-1#799,NA,NA,p.Leu185Ser,1.181243177,1.34e-06,7.440000000000001e-13,-1.181243177 +urn:mavedb:00000041-a-1#800,NA,NA,p.Leu185Pro,1.557996299,1.0199999999999998e-19,3.8e-38,-1.557996299 +urn:mavedb:00000041-a-1#817,NA,NA,p.Leu141Gly,1.7191374680000002,0.4976729520000001,1.6300000000000002e-07,-1.7191374680000002 +urn:mavedb:00000041-a-1#818,NA,NA,p.Leu141Glu,1.524513159,9.64e-08,5.38e-15,-1.524513159 +urn:mavedb:00000041-a-1#819,NA,NA,p.Leu141Gln,1.523950244,1.53e-06,9.44e-13,-1.523950244 +urn:mavedb:00000041-a-1#820,NA,NA,p.Leu141Arg,1.5242869369999998,3.28e-07,5.3e-14,-1.5242869369999998 +urn:mavedb:00000041-a-1#821,NA,NA,p.Leu141Ala,1.494028351,1.41e-11,2.4200000000000003e-22,-1.494028351 +urn:mavedb:00000041-a-1#822,NA,NA,p.Leu132Cys,0.581514596,1.769999999999999e-53,2.829999999999999e-104,-0.581514596 +urn:mavedb:00000041-a-1#823,NA,NA,p.Leu127Thr,0.677817069,0.293869828,1.11e-16,-0.677817069 +urn:mavedb:00000041-a-1#824,NA,NA,p.Leu127Ser,1.531388955,4.14e-08,1.0599999999999999e-15,-1.531388955 +urn:mavedb:00000041-a-1#3310,NA,NA,p.Ile126Met,0.327759414,0.238531722,1.39e-17,-0.327759414 +urn:mavedb:00000041-a-1#846,NA,NA,p.Leu94His,0.996204239,0.236095214,2.91e-07,-0.996204239 +urn:mavedb:00000041-a-1#847,NA,NA,p.Leu94Gly,0.725058147,0.0007778430000000001,5.16e-08,-0.725058147 +urn:mavedb:00000041-a-1#848,NA,NA,p.Leu94Glu,1.102048607,4.42e-16,4.48e-31,-1.102048607 +urn:mavedb:00000041-a-1#849,NA,NA,p.Leu94Gln,0.77854238,4.04e-10,1.5e-19,-0.77854238 +urn:mavedb:00000041-a-1#850,NA,NA,p.Leu94Cys,0.5799498820000001,8.269999999999999e-34,1.0599999999999999e-65,-0.5799498820000001 +urn:mavedb:00000041-a-1#852,NA,NA,p.Leu94Asn,0.638196157,2.2099999999999996e-63,1.159999999999999e-123,-0.638196157 +urn:mavedb:00000041-a-1#853,NA,NA,p.Leu92Pro,0.5009509289999999,0.013576149,8.38e-06,-0.5009509289999999 +urn:mavedb:00000041-a-1#854,NA,NA,p.Leu92Gly,0.91425796,2.39e-41,1.799999999999999e-80,-0.91425796 +urn:mavedb:00000041-a-1#855,NA,NA,p.Leu84Tyr,0.721629009,1.11e-12,1.78e-24,-0.721629009 +urn:mavedb:00000041-a-1#856,NA,NA,p.Leu84Trp,0.552477086,3.03e-18,2.7399999999999996e-35,-0.552477086 +urn:mavedb:00000041-a-1#857,NA,NA,p.Leu84Thr,0.608005823,0.127900899,1.0400000000000002e-17,-0.608005823 +urn:mavedb:00000041-a-1#866,NA,NA,p.Leu84Asn,1.190758133,1.41e-18,6.23e-36,-1.190758133 +urn:mavedb:00000041-a-1#867,NA,NA,p.Leu84Arg,1.40379571,4.98e-11,2.7500000000000006e-21,-1.40379571 +urn:mavedb:00000041-a-1#868,NA,NA,p.Leu81Pro,0.95256225,7.54e-47,2.969999999999998e-91,-0.95256225 +urn:mavedb:00000041-a-1#869,NA,NA,p.Leu80Tyr,0.5055630489999999,0.214796163,5.9100000000000005e-12,-0.5055630489999999 +urn:mavedb:00000041-a-1#870,NA,NA,p.Leu80Ter,1.5631015190000002,5.38e-10,2.67e-19,-1.5631015190000002 +urn:mavedb:00000041-a-1#3375,NA,NA,p.Gly86Ala,0.13479696900000002,4.4e-13,2.56e-25,-0.13479696900000002 +urn:mavedb:00000041-a-1#871,NA,NA,p.Leu80Pro,1.465509882,1.1900000000000002e-13,2.3400000000000003e-26,-1.465509882 +urn:mavedb:00000041-a-1#876,NA,NA,p.Leu80Arg,1.504946031,1.6e-09,2.16e-18,-1.504946031 +urn:mavedb:00000041-a-1#877,NA,NA,p.Leu59Val,1.464609218,2.36e-08,3.62e-16,-1.464609218 +urn:mavedb:00000041-a-1#3003,NA,NA,p.Pro33Ile,0.09553057,0.10455455,0.000365054,-0.09553057 +urn:mavedb:00000041-a-1#789,NA,NA,p.Leu186Lys,1.515665141,1.04e-08,7.700000000000001e-17,-1.515665141 +urn:mavedb:00000041-a-1#790,NA,NA,p.Leu186His,1.336141595,6.509999999999999e-11,4.59e-21,-1.336141595 +urn:mavedb:00000041-a-1#791,NA,NA,p.Leu186Gly,1.058913507,6.819999999999999e-10,4.1e-19,-1.058913507 +urn:mavedb:00000041-a-1#792,NA,NA,p.Leu186Glu,1.405205092,4.34e-19,6.3499999999999996e-37,-1.405205092 +urn:mavedb:00000041-a-1#793,NA,NA,p.Leu186Gln,1.254921374,1.65e-11,3.23e-22,-1.254921374 +urn:mavedb:00000041-a-1#794,NA,NA,p.Leu186Asp,1.671080048,2.17e-06,1.8000000000000004e-12,-1.671080048 +urn:mavedb:00000041-a-1#801,NA,NA,p.Leu185Lys,1.577643149,9.66e-12,1.1599999999999998e-22,-1.577643149 +urn:mavedb:00000041-a-1#802,NA,NA,p.Leu185Ile,0.874519022,6.219999999999998e-45,1.689999999999999e-87,-0.874519022 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+urn:mavedb:00000041-a-1#811,NA,NA,p.Leu141Ter,1.513475084,6.41e-07,1.88e-13,-1.513475084 +urn:mavedb:00000041-a-1#812,NA,NA,p.Leu141Ser,1.42321143,4.34e-34,2.9899999999999996e-66,-1.42321143 +urn:mavedb:00000041-a-1#813,NA,NA,p.Leu141Pro,1.653148752,6.95e-06,1.5499999999999998e-11,-1.653148752 +urn:mavedb:00000041-a-1#814,NA,NA,p.Leu141Met,0.817939747,5.9e-44,1.38e-85,-0.817939747 +urn:mavedb:00000041-a-1#815,NA,NA,p.Leu141Lys,1.380778819,3e-11,1.04e-21,-1.380778819 +urn:mavedb:00000041-a-1#3249,NA,NA,p.Arg52Met,-0.266288313,3e-16,2.2e-31,0.266288313 +urn:mavedb:00000041-a-1#816,NA,NA,p.Leu141Ile,1.480514133,1.84e-08,2.27e-16,-1.480514133 +urn:mavedb:00000041-a-1#825,NA,NA,p.Leu127Pro,1.556658898,9.54e-13,1.3299999999999999e-24,-1.556658898 +urn:mavedb:00000041-a-1#3311,NA,NA,p.Ile126Cys,-0.12833375,2.67e-05,1.74e-10,0.12833375 +urn:mavedb:00000041-a-1#826,NA,NA,p.Leu127Lys,1.110635134,4.65e-42,7.399999999999997e-82,-1.110635134 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+urn:mavedb:00000041-a-1#837,NA,NA,p.Leu94Val,0.497967569,7.77e-13,8.740000000000001e-25,-0.497967569 +urn:mavedb:00000041-a-1#838,NA,NA,p.Leu94Tyr,0.903837236,1.18e-36,2.789999999999999e-71,-0.903837236 +urn:mavedb:00000041-a-1#839,NA,NA,p.Leu94Thr,0.733885303,9.51e-19,2.86e-36,-0.733885303 +urn:mavedb:00000041-a-1#840,NA,NA,p.Leu94Ser,0.732778433,2.7400000000000004e-12,9.92e-24,-0.732778433 +urn:mavedb:00000041-a-1#841,NA,NA,p.Leu94Pro,0.791659538,3.9100000000000005e-10,1.43e-19,-0.791659538 +urn:mavedb:00000041-a-1#842,NA,NA,p.Leu94Phe,0.599418191,2.689999999999999e-21,3.1e-41,-0.599418191 +urn:mavedb:00000041-a-1#843,NA,NA,p.Leu94Met,0.825967846,0.00060845,3.33e-08,-0.825967846 +urn:mavedb:00000041-a-1#844,NA,NA,p.Leu94Lys,0.610862819,3.2599999999999995e-42,3.5899999999999996e-82,-0.610862819 +urn:mavedb:00000041-a-1#845,NA,NA,p.Leu94Ile,0.584324588,2.21e-24,2.9e-47,-0.584324588 +urn:mavedb:00000041-a-1#851,NA,NA,p.Leu94Asp,0.943825894,2.29e-22,2.52e-43,-0.943825894 +urn:mavedb:00000041-a-1#3312,NA,NA,p.Ile104Val,0.241338741,0.209088322,0.0,-0.241338741 +urn:mavedb:00000041-a-1#858,NA,NA,p.Leu84Ter,1.7004095730000002,8.859999999999998e-10,6.8900000000000005e-19,-1.7004095730000002 +urn:mavedb:00000041-a-1#859,NA,NA,p.Leu84Pro,1.6546413290000002,0.000117233,2.48e-09,-1.6546413290000002 +urn:mavedb:00000041-a-1#860,NA,NA,p.Leu84Lys,1.529956857,1.15e-14,2.55e-28,-1.529956857 +urn:mavedb:00000041-a-1#861,NA,NA,p.Leu84His,1.37415282,1.56e-06,9.69e-13,-1.37415282 +urn:mavedb:00000041-a-1#862,NA,NA,p.Leu84Gly,1.3921960009999998,8.059999999999999e-09,4.6899999999999995e-17,-1.3921960009999998 +urn:mavedb:00000041-a-1#863,NA,NA,p.Leu84Glu,1.085500581,2.25e-15,1.06e-29,-1.085500581 +urn:mavedb:00000041-a-1#864,NA,NA,p.Leu84Gln,0.728344709,6.89e-16,1.06e-30,-0.728344709 +urn:mavedb:00000041-a-1#3343,NA,NA,p.Gly199Asp,0.071837617,0.128940582,3.47e-18,-0.071837617 +urn:mavedb:00000041-a-1#865,NA,NA,p.Leu84Asp,1.562838863,1.7899999999999998e-11,3.9e-22,-1.562838863 +urn:mavedb:00000041-a-1#872,NA,NA,p.Leu80Lys,1.66568459,2.2e-09,3.92e-18,-1.66568459 +urn:mavedb:00000041-a-1#873,NA,NA,p.Leu80His,1.540121881,3.2e-05,2.53e-10,-1.540121881 +urn:mavedb:00000041-a-1#874,NA,NA,p.Leu80Asp,1.5492543980000002,5.75e-13,5.02e-25,-1.5492543980000002 +urn:mavedb:00000041-a-1#875,NA,NA,p.Leu80Asn,1.246716091,3.7799999999999994e-31,1.72e-60,-1.246716091 +urn:mavedb:00000041-a-1#885,NA,NA,p.Leu56Tyr,1.597298312,7.37e-06,1.73e-11,-1.597298312 +urn:mavedb:00000041-a-1#878,NA,NA,p.Leu59Tyr,1.5030855980000002,0.053540222,0.000190052,-1.5030855980000002 +urn:mavedb:00000041-a-1#879,NA,NA,p.Leu59Pro,1.300552098,0.000113118,2.43e-09,-1.300552098 +urn:mavedb:00000041-a-1#880,NA,NA,p.Leu59Phe,1.6403510890000002,3.4900000000000004e-11,1.3699999999999996e-21,-1.6403510890000002 +urn:mavedb:00000041-a-1#881,NA,NA,p.Leu59Met,0.960600445,0.000103442,1.61e-09,-0.960600445 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+urn:mavedb:00000041-a-1#35,NA,NA,p.Tyr170His,0.5547897620000001,7.87e-31,6.92e-60,-0.5547897620000001 +urn:mavedb:00000041-a-1#3,NA,NA,p.Val15Glu,1.481809819,3.96e-14,2.82e-27,-1.481809819 +urn:mavedb:00000041-a-1#4,NA,NA,p.Val15Gln,1.372176194,7.31e-10,4.79e-19,-1.372176194 +urn:mavedb:00000041-a-1#5,NA,NA,p.Val15Cys,1.013862994,0.296683225,3.9e-07,-1.013862994 +urn:mavedb:00000041-a-1#6,NA,NA,p.Val15Asp,1.551066156,2.27e-11,6.11e-22,-1.551066156 +urn:mavedb:00000041-a-1#7,NA,NA,p.Val15Asn,1.568905117,6.7799999999999985e-09,3.41e-17,-1.568905117 +urn:mavedb:00000041-a-1#8,NA,NA,p.Val15Arg,1.5312235180000002,1.24e-10,1.6000000000000002e-20,-1.5312235180000002 +urn:mavedb:00000041-a-1#9,NA,NA,p.Val15Ala,0.757230463,1.91e-20,1.39e-39,-0.757230463 +urn:mavedb:00000041-a-1#10,NA,NA,p.Val5Ter,1.54934292,0.0016609220000000002,2.05e-07,-1.54934292 +urn:mavedb:00000041-a-1#11,NA,NA,p.Tyr245Asp,0.541145206,0.077531512,0.000402485,-0.541145206 +urn:mavedb:00000041-a-1#12,NA,NA,p.Tyr245Asn,0.485860579,0.680093518,2.19e-10,-0.485860579 +urn:mavedb:00000041-a-1#13,NA,NA,p.Tyr213Val,0.80490602,3.71e-32,1.7899999999999994e-62,-0.80490602 +urn:mavedb:00000041-a-1#14,NA,NA,p.Tyr213Trp,0.493638392,1.6399999999999999e-29,2.68e-57,-0.493638392 +urn:mavedb:00000041-a-1#15,NA,NA,p.Tyr213Thr,1.187528528,1.17e-16,3.36e-32,-1.187528528 +urn:mavedb:00000041-a-1#16,NA,NA,p.Tyr213Ter,1.574003849,8.29e-11,7.37e-21,-1.574003849 +urn:mavedb:00000041-a-1#17,NA,NA,p.Tyr213Ser,0.932024628,4.5e-21,8.48e-41,-0.932024628 +urn:mavedb:00000041-a-1#18,NA,NA,p.Tyr213Pro,1.489015961,1.07e-11,1.42e-22,-1.489015961 +urn:mavedb:00000041-a-1#19,NA,NA,p.Tyr213Lys,0.8696293409999999,7.840000000000001e-25,3.84e-48,-0.8696293409999999 +urn:mavedb:00000041-a-1#20,NA,NA,p.Tyr213Ile,0.787300951,1.1699999999999998e-91,4.099999999999997e-179,-0.787300951 +urn:mavedb:00000041-a-1#21,NA,NA,p.Tyr213His,0.66417735,8.41e-49,4.339999999999998e-95,-0.66417735 +urn:mavedb:00000041-a-1#22,NA,NA,p.Tyr213Gly,0.887284484,2.33e-23,2.8899999999999994e-45,-0.887284484 +urn:mavedb:00000041-a-1#23,NA,NA,p.Tyr213Glu,0.957494647,1.8e-23,1.76e-45,-0.957494647 +urn:mavedb:00000041-a-1#24,NA,NA,p.Tyr213Gln,0.875217968,4.33e-26,1.34e-50,-0.875217968 +urn:mavedb:00000041-a-1#25,NA,NA,p.Tyr213Cys,0.714320554,1.25e-24,9.439999999999999e-48,-0.714320554 +urn:mavedb:00000041-a-1#26,NA,NA,p.Tyr213Asp,1.233825188,1.24e-21,6.919999999999999e-42,-1.233825188 +urn:mavedb:00000041-a-1#27,NA,NA,p.Tyr213Asn,0.906960853,1.83e-35,5.969999999999998e-69,-0.906960853 +urn:mavedb:00000041-a-1#28,NA,NA,p.Tyr213Arg,0.782322222,2.37e-22,2.68e-43,-0.782322222 +urn:mavedb:00000041-a-1#29,NA,NA,p.Tyr213Ala,0.7873621000000001,1.0199999999999999e-21,4.59e-42,-0.7873621000000001 +urn:mavedb:00000041-a-1#978,NA,NA,p.Ile104Lys,1.6240124459999998,2.25e-10,5.0599999999999995e-20,-1.6240124459999998 +urn:mavedb:00000041-a-1#979,NA,NA,p.Ile104Leu,0.952145936,0.004658794,1.02e-07,-0.952145936 +urn:mavedb:00000041-a-1#980,NA,NA,p.Ile104Gly,1.256957042,1.5499999999999998e-11,2.88e-22,-1.256957042 +urn:mavedb:00000041-a-1#981,NA,NA,p.Ile104Glu,1.612600356,0.216334234,0.000709804,-1.612600356 +urn:mavedb:00000041-a-1#982,NA,NA,p.Ile104Asp,1.683173751,0.195055161,0.00187866,-1.683173751 +urn:mavedb:00000041-a-1#983,NA,NA,p.Ile104Arg,1.551903167,1.4000000000000002e-21,8.69e-42,-1.551903167 +urn:mavedb:00000041-a-1#984,NA,NA,p.Ile104Ala,0.767160517,5.8e-07,1.51e-13,-0.767160517 +urn:mavedb:00000041-a-1#985,NA,NA,p.Ile70Val,0.743078282,1.21e-18,4.61e-36,-0.743078282 +urn:mavedb:00000041-a-1#986,NA,NA,p.Ile70Tyr,1.554658298,6.999999999999999e-17,1.26e-32,-1.554658298 +urn:mavedb:00000041-a-1#987,NA,NA,p.Ile70Trp,1.79248253,0.361591939,5.02e-06,-1.79248253 +urn:mavedb:00000041-a-1#988,NA,NA,p.Ile70Thr,1.466403411,2.36e-14,1.03e-27,-1.466403411 +urn:mavedb:00000041-a-1#989,NA,NA,p.Ile70Ter,1.672112595,2.41e-09,4.73e-18,-1.672112595 +urn:mavedb:00000041-a-1#990,NA,NA,p.Ile70Ser,1.5702552019999998,2.1600000000000007e-05,1.25e-10,-1.5702552019999998 +urn:mavedb:00000041-a-1#991,NA,NA,p.Ile70Pro,1.60395403,6.929999999999999e-05,1.02e-09,-1.60395403 +urn:mavedb:00000041-a-1#992,NA,NA,p.Ile70Phe,1.411958216,2.24e-07,2.59e-14,-1.411958216 +urn:mavedb:00000041-a-1#993,NA,NA,p.Ile70Met,1.3984060130000002,1.4e-09,1.68e-18,-1.3984060130000002 +urn:mavedb:00000041-a-1#994,NA,NA,p.Ile70Lys,1.7402077619999998,0.088098527,0.00056149,-1.7402077619999998 +urn:mavedb:00000041-a-1#995,NA,NA,p.Ile70Gly,1.558001469,2.74e-10,7.35e-20,-1.558001469 +urn:mavedb:00000041-a-1#996,NA,NA,p.Ile70Glu,1.51201825,9.34e-09,6.27e-17,-1.51201825 +urn:mavedb:00000041-a-1#997,NA,NA,p.Ile70Gln,1.225181778,1.31e-07,9.19e-15,-1.225181778 +urn:mavedb:00000041-a-1#998,NA,NA,p.Ile70Cys,1.228455171,8.86e-08,4.470000000000001e-15,-1.228455171 +urn:mavedb:00000041-a-1#999,NA,NA,p.Ile70Asp,1.537537124,2.46e-16,1.4599999999999999e-31,-1.537537124 +urn:mavedb:00000041-a-1#1000,NA,NA,p.Phe158Ala,1.5019033730000002,2.83e-14,1.46e-27,-1.5019033730000002 +urn:mavedb:00000041-a-1#1001,NA,NA,p.Phe139Tyr,1.527361755,1.74e-07,1.61e-14,-1.527361755 +urn:mavedb:00000041-a-1#1002,NA,NA,p.Phe139Thr,1.66950738,0.30927793,0.000305616,-1.66950738 +urn:mavedb:00000041-a-1#1003,NA,NA,p.Phe139Ser,1.567678757,2.15e-06,1.78e-12,-1.567678757 +urn:mavedb:00000041-a-1#1004,NA,NA,p.Phe139Pro,1.510024132,3.35e-11,1.27e-21,-1.510024132 +urn:mavedb:00000041-a-1#1005,NA,NA,p.Phe139Met,1.334892282,9.4e-11,9.47e-21,-1.334892282 +urn:mavedb:00000041-a-1#1006,NA,NA,p.Phe139Lys,1.502277777,2.76e-06,2.8700000000000005e-12,-1.502277777 +urn:mavedb:00000041-a-1#1007,NA,NA,p.Phe139Leu,1.5363000219999998,4.1799999999999996e-17,4.65e-33,-1.5363000219999998 +urn:mavedb:00000041-a-1#1008,NA,NA,p.Phe139Gly,1.727193463,0.0007296000000000001,5.36e-08,-1.727193463 +urn:mavedb:00000041-a-1#1009,NA,NA,p.Phe139Gln,1.407015424,1.89e-06,1.4e-12,-1.407015424 +urn:mavedb:00000041-a-1#1010,NA,NA,p.Phe139Asn,1.679333704,3.14e-08,6.2199999999999995e-16,-1.679333704 +urn:mavedb:00000041-a-1#1011,NA,NA,p.Phe139Arg,1.4637821640000002,0.418425177,1.4e-06,-1.4637821640000002 +urn:mavedb:00000041-a-1#1012,NA,NA,p.Phe139Ala,1.59442696,1.8600000000000004e-20,1.3699999999999997e-39,-1.59442696 +urn:mavedb:00000041-a-1#1013,NA,NA,p.Phe83Ter,1.123478223,0.605876054,1.1100000000000002e-08,-1.123478223 +urn:mavedb:00000041-a-1#1014,NA,NA,p.Phe83Pro,1.033721421,1.74e-33,4.45e-65,-1.033721421 +urn:mavedb:00000041-a-1#1015,NA,NA,p.Phe83Gly,0.8287334940000001,0.003637929,2.18e-07,-0.8287334940000001 +urn:mavedb:00000041-a-1#1016,NA,NA,p.Phe83Glu,0.476737193,1.55e-22,1.16e-43,-0.476737193 +urn:mavedb:00000041-a-1#1017,NA,NA,p.Phe83Gln,0.542213185,0.040871021,9.21e-07,-0.542213185 +urn:mavedb:00000041-a-1#1018,NA,NA,p.Phe83Asp,0.873675215,1.4899999999999996e-80,2.4499999999999992e-157,-0.873675215 +urn:mavedb:00000041-a-1#1019,NA,NA,p.Phe83Arg,0.595726399,1.18e-17,3.7999999999999997e-34,-0.595726399 +urn:mavedb:00000041-a-1#1020,NA,NA,p.Phe41Ter,1.831573061,5.18e-06,9.12e-12,-1.831573061 +urn:mavedb:00000041-a-1#1021,NA,NA,p.Phe41Met,1.306734722,4.22e-14,3.18e-27,-1.306734722 +urn:mavedb:00000041-a-1#1022,NA,NA,p.Phe41Leu,1.420194409,3.33e-19,3.8e-37,-1.420194409 +urn:mavedb:00000041-a-1#1023,NA,NA,p.Phe41His,1.642746307,0.003876991,3.53e-07,-1.642746307 +urn:mavedb:00000041-a-1#1024,NA,NA,p.Phe41Gly,1.137346245,1.28e-22,8.14e-44,-1.137346245 +urn:mavedb:00000041-a-1#1025,NA,NA,p.Phe41Glu,1.49309591,1.36e-11,2.24e-22,-1.49309591 +urn:mavedb:00000041-a-1#1026,NA,NA,p.Phe12Val,1.59371928,4.53e-05,4.91e-10,-1.59371928 +urn:mavedb:00000041-a-1#1027,NA,NA,p.Phe12Tyr,1.397181286,6.88e-15,9.4e-29,-1.397181286 +urn:mavedb:00000041-a-1#1028,NA,NA,p.Phe12Thr,1.592808719,3.62e-07,6.38e-14,-1.592808719 +urn:mavedb:00000041-a-1#1029,NA,NA,p.Phe12Ser,1.556457821,5.88e-16,7.9e-31,-1.556457821 +urn:mavedb:00000041-a-1#1030,NA,NA,p.Phe12Leu,1.609141833,7.2400000000000015e-12,6.65e-23,-1.609141833 +urn:mavedb:00000041-a-1#1031,NA,NA,p.Phe12His,1.178976746,0.397782095,1.11e-16,-1.178976746 +urn:mavedb:00000041-a-1#1032,NA,NA,p.Phe12Gly,1.544596551,2.25e-16,1.2099999999999999e-31,-1.544596551 +urn:mavedb:00000041-a-1#1033,NA,NA,p.Phe12Glu,1.649085287,1.1e-08,8.44e-17,-1.649085287 +urn:mavedb:00000041-a-1#1034,NA,NA,p.Phe12Gln,1.507968578,2.11e-07,2.28e-14,-1.507968578 +urn:mavedb:00000041-a-1#1035,NA,NA,p.Phe12Cys,1.5081156059999998,1.8100000000000006e-13,5.34e-26,-1.5081156059999998 +urn:mavedb:00000041-a-1#1036,NA,NA,p.Phe12Asn,1.4166729669999998,8.68e-06,2.38e-11,-1.4166729669999998 +urn:mavedb:00000041-a-1#1038,NA,NA,p.Phe12Ala,1.4412795369999998,2.6e-08,4.37e-16,-1.4412795369999998 +urn:mavedb:00000041-a-1#1039,NA,NA,p.Met229Pro,0.8276777759999999,1.88e-14,6.4699999999999995e-28,-0.8276777759999999 +urn:mavedb:00000041-a-1#1040,NA,NA,p.Met229Asn,0.510004595,0.361256706,0.0,-0.510004595 +urn:mavedb:00000041-a-1#1041,NA,NA,p.Met229Arg,1.59483449,0.421444187,1.59e-12,-1.59483449 +urn:mavedb:00000041-a-1#1042,NA,NA,p.Met229Ala,0.6968927090000001,6.99e-21,1.93e-40,-0.6968927090000001 +urn:mavedb:00000041-a-1#1043,NA,NA,p.Met215Val,0.685120134,8.67e-36,1.3899999999999995e-69,-0.685120134 +urn:mavedb:00000041-a-1#1044,NA,NA,p.Met215Tyr,1.372004335,4.55e-21,8.77e-41,-1.372004335 +urn:mavedb:00000041-a-1#1045,NA,NA,p.Met215Trp,1.485689814,7.62e-14,1e-26,-1.485689814 +urn:mavedb:00000041-a-1#1046,NA,NA,p.Met215Thr,0.688430608,4.36e-32,2.4399999999999994e-62,-0.688430608 +urn:mavedb:00000041-a-1#1047,NA,NA,p.Met215Ter,1.574286007,6.710000000000001e-10,4.070000000000001e-19,-1.574286007 +urn:mavedb:00000041-a-1#1048,NA,NA,p.Met215Ser,0.677436855,2.4199999999999996e-48,3.4799999999999975e-94,-0.677436855 +urn:mavedb:00000041-a-1#1049,NA,NA,p.Met215Lys,1.009503165,4.8399999999999994e-45,1.0499999999999996e-87,-1.009503165 +urn:mavedb:00000041-a-1#1050,NA,NA,p.Met215His,1.208184893,6.68e-05,9.37e-10,-1.208184893 +urn:mavedb:00000041-a-1#1051,NA,NA,p.Met215Gly,1.521097713,1.28e-12,2.36e-24,-1.521097713 +urn:mavedb:00000041-a-1#1052,NA,NA,p.Met215Cys,0.50362428,0.215318477,2.0800000000000003e-17,-0.50362428 +urn:mavedb:00000041-a-1#1053,NA,NA,p.Met215Asp,1.272349123,1.27e-21,7.22e-42,-1.272349123 +urn:mavedb:00000041-a-1#1054,NA,NA,p.Met215Arg,1.555597135,1.19e-11,1.75e-22,-1.555597135 +urn:mavedb:00000041-a-1#1055,NA,NA,p.Met215Ala,0.7033144729999999,6.909999999999999e-17,1.1999999999999999e-32,-0.7033144729999999 +urn:mavedb:00000041-a-1#1056,NA,NA,p.Met200Val,0.891435465,7.77e-05,1.1e-09,-0.891435465 +urn:mavedb:00000041-a-1#1057,NA,NA,p.Met200Thr,0.565817526,2.89e-10,7.69e-20,-0.565817526 +urn:mavedb:00000041-a-1#1058,NA,NA,p.Met200Ter,1.571957778,2.62e-06,2.5299999999999995e-12,-1.571957778 +urn:mavedb:00000041-a-1#1059,NA,NA,p.Met200Ser,0.490025553,4e-42,5.269999999999997e-82,-0.490025553 +urn:mavedb:00000041-a-1#1060,NA,NA,p.Met200Pro,1.531479035,0.855186538,0.0,-1.531479035 +urn:mavedb:00000041-a-1#1061,NA,NA,p.Met200Ile,0.949956061,8.84e-12,9.479999999999999e-23,-0.949956061 +urn:mavedb:00000041-a-1#1062,NA,NA,p.Met200His,0.488379646,3.7499999999999994e-47,7.389999999999996e-92,-0.488379646 +urn:mavedb:00000041-a-1#1063,NA,NA,p.Met200Gly,1.202986584,4.1e-24,9.890000000000001e-47,-1.202986584 +urn:mavedb:00000041-a-1#1064,NA,NA,p.Met200Asp,1.241011556,3.99e-10,1.51e-19,-1.241011556 +urn:mavedb:00000041-a-1#1065,NA,NA,p.Ile70Asn,1.4030837719999998,3.73e-07,6.58e-14,-1.4030837719999998 +urn:mavedb:00000041-a-1#1066,NA,NA,p.Ile70Arg,1.562225516,1.41e-07,1.08e-14,-1.562225516 +urn:mavedb:00000041-a-1#1067,NA,NA,p.Ile70Ala,1.438065238,7.48e-15,1.1e-28,-1.438065238 +urn:mavedb:00000041-a-1#1068,NA,NA,p.Ile68Val,0.630142045,4.8399999999999995e-36,4.339999999999997e-70,-0.630142045 +urn:mavedb:00000041-a-1#1069,NA,NA,p.Ile68Pro,1.005633401,8.009999999999998e-23,3.29e-44,-1.005633401 +urn:mavedb:00000041-a-1#1070,NA,NA,p.Ile68Lys,0.912847874,4.859999999999999e-45,1.0399999999999996e-87,-0.912847874 +urn:mavedb:00000041-a-1#1071,NA,NA,p.Ile68Gln,1.514678482,1.39e-07,1.02e-14,-1.514678482 +urn:mavedb:00000041-a-1#1072,NA,NA,p.Ile68Asn,0.492095352,0.798783081,6.63e-12,-0.492095352 +urn:mavedb:00000041-a-1#1073,NA,NA,p.Ile28Ter,1.6183442380000002,1.73e-13,4.9299999999999987e-26,-1.6183442380000002 +urn:mavedb:00000041-a-1#1074,NA,NA,p.Ile28Pro,1.617638055,2.23e-10,4.8600000000000006e-20,-1.617638055 +urn:mavedb:00000041-a-1#1075,NA,NA,p.Ile28His,1.565539974,3.55e-05,2.94e-10,-1.565539974 +urn:mavedb:00000041-a-1#1076,NA,NA,p.Ile28Asp,1.840541339,0.4887262570000001,2.87e-09,-1.840541339 +urn:mavedb:00000041-a-1#1077,NA,NA,p.Ile28Asn,1.19883768,0.369451067,3.25e-07,-1.19883768 +urn:mavedb:00000041-a-1#1078,NA,NA,p.Ile28Arg,1.4273166169999998,5.859999999999999e-13,5.18e-25,-1.4273166169999998 +urn:mavedb:00000041-a-1#1079,NA,NA,p.His226Val,0.529577144,1.97e-10,3.68e-20,-0.529577144 +urn:mavedb:00000041-a-1#1080,NA,NA,p.His226Tyr,1.200996861,2.57e-13,9.98e-26,-1.200996861 +urn:mavedb:00000041-a-1#1081,NA,NA,p.His226Ter,1.5608877680000002,0.307414195,7.54e-06,-1.5608877680000002 +urn:mavedb:00000041-a-1#1082,NA,NA,p.His226Pro,1.548149964,2.78e-11,8.97e-22,-1.548149964 +urn:mavedb:00000041-a-1#1083,NA,NA,p.His226Leu,0.894341365,2.61e-57,9.219999999999997e-112,-0.894341365 +urn:mavedb:00000041-a-1#1084,NA,NA,p.His226Ile,0.869187073,3.41e-31,1.37e-60,-0.869187073 +urn:mavedb:00000041-a-1#1085,NA,NA,p.His118Val,1.68374548,1.78e-14,5.92e-28,-1.68374548 +urn:mavedb:00000041-a-1#1086,NA,NA,p.His118Tyr,1.465868952,8.7e-11,8.050000000000001e-21,-1.465868952 +urn:mavedb:00000041-a-1#1087,NA,NA,p.His118Thr,1.589105871,0.00872655,3.2e-07,-1.589105871 +urn:mavedb:00000041-a-1#1088,NA,NA,p.His118Phe,1.217006562,4.34e-18,5.66e-35,-1.217006562 +urn:mavedb:00000041-a-1#1089,NA,NA,p.His118Met,1.5202418880000002,0.055556865,0.000196809,-1.5202418880000002 +urn:mavedb:00000041-a-1#1090,NA,NA,p.His118Leu,1.59715235,4.94e-05,5.42e-10,-1.59715235 +urn:mavedb:00000041-a-1#1091,NA,NA,p.Gly107Trp,1.625999914,0.000173757,4.94e-09,-1.625999914 +urn:mavedb:00000041-a-1#1092,NA,NA,p.Gly107Thr,1.446517134,3.87e-11,1.6899999999999996e-21,-1.446517134 +urn:mavedb:00000041-a-1#1093,NA,NA,p.Gly107Ter,1.286897041,4.87e-12,3.12e-23,-1.286897041 +urn:mavedb:00000041-a-1#1094,NA,NA,p.Gly107Ser,0.911420754,6.52e-30,4.44e-58,-0.911420754 +urn:mavedb:00000041-a-1#1095,NA,NA,p.Gly107Pro,1.631441581,1.24e-07,8.45e-15,-1.631441581 +urn:mavedb:00000041-a-1#1096,NA,NA,p.Gly107Phe,1.5845882569999998,3.97e-11,1.7899999999999993e-21,-1.5845882569999998 +urn:mavedb:00000041-a-1#1097,NA,NA,p.Gly107Lys,1.643037985,1.36e-11,2.24e-22,-1.643037985 +urn:mavedb:00000041-a-1#1098,NA,NA,p.Gly107Leu,1.625907527,8.190000000000001e-05,1.3300000000000002e-09,-1.625907527 +urn:mavedb:00000041-a-1#1099,NA,NA,p.Gly107Glu,1.49778566,8.22e-15,1.33e-28,-1.49778566 +urn:mavedb:00000041-a-1#1100,NA,NA,p.Gly107Gln,1.385892539,5.31e-26,2.0299999999999996e-50,-1.385892539 +urn:mavedb:00000041-a-1#1101,NA,NA,p.Gly107Asp,1.372011492,1.04e-15,2.4199999999999997e-30,-1.372011492 +urn:mavedb:00000041-a-1#1102,NA,NA,p.Gly107Arg,1.640376789,2.07e-09,3.5000000000000014e-18,-1.640376789 +urn:mavedb:00000041-a-1#1103,NA,NA,p.Gly86Tyr,0.7165815409999999,2.21e-28,4.25e-55,-0.7165815409999999 +urn:mavedb:00000041-a-1#1104,NA,NA,p.Gly86Ter,1.6870342459999998,0.042546059,0.000107601,-1.6870342459999998 +urn:mavedb:00000041-a-1#1105,NA,NA,p.Gly86Met,0.694322827,4.13e-09,1.18e-17,-0.694322827 +urn:mavedb:00000041-a-1#1106,NA,NA,p.Gly86Asp,0.877625001,8.7e-11,7.77e-21,-0.877625001 +urn:mavedb:00000041-a-1#1107,NA,NA,p.Gly78Val,1.51591222,1.55e-07,1.3e-14,-1.51591222 +urn:mavedb:00000041-a-1#1108,NA,NA,p.Gly78Tyr,1.176601344,6.3e-18,1.1499999999999998e-34,-1.176601344 +urn:mavedb:00000041-a-1#1109,NA,NA,p.Gly78Trp,1.191622158,6.24e-18,1.1299999999999998e-34,-1.191622158 +urn:mavedb:00000041-a-1#1110,NA,NA,p.Gly78Thr,0.925894396,6.97e-12,6.14e-23,-0.925894396 +urn:mavedb:00000041-a-1#1111,NA,NA,p.Gly78Ter,1.577674501,1.01e-11,1.27e-22,-1.577674501 +urn:mavedb:00000041-a-1#1112,NA,NA,p.Gly78Pro,1.4893252280000002,4.25e-05,4.18e-10,-1.4893252280000002 +urn:mavedb:00000041-a-1#1113,NA,NA,p.Gly78Phe,0.953867185,4.51e-17,5.34e-33,-0.953867185 +urn:mavedb:00000041-a-1#1114,NA,NA,p.Gly78Met,0.836821485,9.13e-21,3.34e-40,-0.836821485 +urn:mavedb:00000041-a-1#1115,NA,NA,p.Gly78Ile,1.385044783,2.9600000000000005e-09,6.9199999999999994e-18,-1.385044783 +urn:mavedb:00000041-a-1#1116,NA,NA,p.Gly78Glu,1.121834046,1.17e-13,2.27e-26,-1.121834046 +urn:mavedb:00000041-a-1#1117,NA,NA,p.Gly78Gln,0.837211612,1.1699999999999999e-32,1.8499999999999998e-63,-0.837211612 +urn:mavedb:00000041-a-1#1118,NA,NA,p.Gly78Asp,0.79066787,6.3900000000000005e-09,2.98e-17,-0.79066787 +urn:mavedb:00000041-a-1#1119,NA,NA,p.Gly78Ala,0.564156085,2.21e-18,1.44e-35,-0.564156085 +urn:mavedb:00000041-a-1#1120,NA,NA,p.Gly18Val,1.343997581,3.63e-06,4.73e-12,-1.343997581 +urn:mavedb:00000041-a-1#1121,NA,NA,p.Gly18Ter,1.560545172,6.439999999999999e-10,3.779999999999999e-19,-1.560545172 +urn:mavedb:00000041-a-1#1122,NA,NA,p.Gly18Pro,1.517774777,1.33e-07,9.7e-15,-1.517774777 +urn:mavedb:00000041-a-1#1123,NA,NA,p.Gly18Phe,0.552230847,2.54e-05,1.43e-10,-0.552230847 +urn:mavedb:00000041-a-1#1124,NA,NA,p.Gly18Lys,1.566393011,3.16e-06,3.71e-12,-1.566393011 +urn:mavedb:00000041-a-1#1125,NA,NA,p.Gly18Leu,1.623976672,1.95e-09,3.18e-18,-1.623976672 +urn:mavedb:00000041-a-1#1126,NA,NA,p.Gly18Ile,1.692656526,0.049863219,0.000157242,-1.692656526 +urn:mavedb:00000041-a-1#1127,NA,NA,p.Gly18His,1.170097522,4.38e-06,6.480000000000001e-12,-1.170097522 +urn:mavedb:00000041-a-1#1128,NA,NA,p.Gly18Glu,1.565432952,3.2200000000000004e-08,6.56e-16,-1.565432952 +urn:mavedb:00000041-a-1#1129,NA,NA,p.Gly18Gln,1.0082002840000002,1.72e-09,2.46e-18,-1.0082002840000002 +urn:mavedb:00000041-a-1#1130,NA,NA,p.Gly18Asp,1.112419795,1.26e-19,5.72e-38,-1.112419795 +urn:mavedb:00000041-a-1#1131,NA,NA,p.Gly18Asn,1.399678265,2.8000000000000003e-09,6.18e-18,-1.399678265 +urn:mavedb:00000041-a-1#1132,NA,NA,p.Gly18Arg,1.554075787,1.25e-09,1.34e-18,-1.554075787 +urn:mavedb:00000041-a-1#1133,NA,NA,p.Gly13Val,1.656476487,1.58e-08,1.6899999999999999e-16,-1.656476487 +urn:mavedb:00000041-a-1#1134,NA,NA,p.Gly13Tyr,1.046147962,5.799999999999999e-31,3.939999999999999e-60,-1.046147962 +urn:mavedb:00000041-a-1#1135,NA,NA,p.Gly13Ser,1.368803679,4.08e-06,5.93e-12,-1.368803679 +urn:mavedb:00000041-a-1#1136,NA,NA,p.Gly13Pro,1.512672746,2.78e-16,1.83e-31,-1.512672746 +urn:mavedb:00000041-a-1#1137,NA,NA,p.Gly13Phe,1.466337201,0.024353107,2.26e-05,-1.466337201 +urn:mavedb:00000041-a-1#1138,NA,NA,p.Gly13Lys,1.560478196,1.33e-08,1.24e-16,-1.560478196 +urn:mavedb:00000041-a-1#1139,NA,NA,p.Gly13Leu,1.528930634,3.06e-05,2.29e-10,-1.528930634 +urn:mavedb:00000041-a-1#1140,NA,NA,p.Gly13Ile,1.7136681,0.000419752,2.26e-08,-1.7136681 +urn:mavedb:00000041-a-1#1141,NA,NA,p.Gly13Asp,1.533955682,6.23e-06,1.3e-11,-1.533955682 +urn:mavedb:00000041-a-1#1142,NA,NA,p.Gly13Asn,1.540074035,4.03e-08,1e-15,-1.540074035 +urn:mavedb:00000041-a-1#1143,NA,NA,p.Gly13Arg,1.430121921,6.409999999999999e-13,6.2e-25,-1.430121921 +urn:mavedb:00000041-a-1#1144,NA,NA,p.Gly13Ala,1.011396313,6.379999999999997e-63,9.169999999999998e-123,-1.011396313 +urn:mavedb:00000041-a-1#1145,NA,NA,p.Gly10Val,1.491383404,4.43e-14,3.52e-27,-1.491383404 +urn:mavedb:00000041-a-1#1146,NA,NA,p.Gly10Tyr,1.71089028,1.3e-08,1.17e-16,-1.71089028 +urn:mavedb:00000041-a-1#1147,NA,NA,p.Gly10Trp,1.5850466840000002,1.5e-05,6.36e-11,-1.5850466840000002 +urn:mavedb:00000041-a-1#1148,NA,NA,p.Gly10Thr,1.759999329,1.17e-16,3.39e-32,-1.759999329 +urn:mavedb:00000041-a-1#1149,NA,NA,p.Gly10Ser,1.650831929,5.860000000000002e-16,7.85e-31,-1.650831929 +urn:mavedb:00000041-a-1#1150,NA,NA,p.Gly10Pro,1.629838869,0.003654185,4.73e-07,-1.629838869 +urn:mavedb:00000041-a-1#1151,NA,NA,p.Gly10Phe,1.560414133,1.2e-08,1.02e-16,-1.560414133 +urn:mavedb:00000041-a-1#1152,NA,NA,p.Gly10Met,1.564698166,4.5e-12,2.6800000000000003e-23,-1.564698166 +urn:mavedb:00000041-a-1#1153,NA,NA,p.Gly10Lys,1.78971927,0.264923752,0.0006829469999999999,-1.78971927 +urn:mavedb:00000041-a-1#1154,NA,NA,p.Gly10Leu,1.66882611,9.72e-06,2.89e-11,-1.66882611 +urn:mavedb:00000041-a-1#1155,NA,NA,p.Gly10Ile,1.633780705,0.000824347,6.38e-08,-1.633780705 +urn:mavedb:00000041-a-1#1156,NA,NA,p.Gly10His,1.436873799,1.49e-12,3.16e-24,-1.436873799 +urn:mavedb:00000041-a-1#1157,NA,NA,p.Gly10Glu,1.3954833640000002,1.3900000000000001e-15,4.3199999999999995e-30,-1.3954833640000002 +urn:mavedb:00000041-a-1#1158,NA,NA,p.Gly10Asp,1.5205831230000002,1.82e-10,3.32e-20,-1.5205831230000002 +urn:mavedb:00000041-a-1#1159,NA,NA,p.Gly10Arg,1.557456969,0.000816566,6.22e-08,-1.557456969 +urn:mavedb:00000041-a-1#1160,NA,NA,p.Gly10Ala,1.6979114430000002,2.83e-69,3.239999999999998e-135,-1.6979114430000002 +urn:mavedb:00000041-a-1#1161,NA,NA,p.Gly8Val,1.616757644,1.21e-08,1.02e-16,-1.616757644 +urn:mavedb:00000041-a-1#1162,NA,NA,p.Gly8Ter,1.714946671,0.07334616599999999,0.000369166,-1.714946671 +urn:mavedb:00000041-a-1#1163,NA,NA,p.Gly8Ser,1.456185158,1.14e-12,1.89e-24,-1.456185158 +urn:mavedb:00000041-a-1#1164,NA,NA,p.Gly8Pro,1.707307461,8.379999999999998e-23,3.57e-44,-1.707307461 +urn:mavedb:00000041-a-1#1165,NA,NA,p.Gly8Met,1.5409357730000002,0.263682655,0.000432796,-1.5409357730000002 +urn:mavedb:00000041-a-1#1166,NA,NA,p.Gly8Lys,1.543923098,3.21e-19,3.570000000000001e-37,-1.543923098 +urn:mavedb:00000041-a-1#1167,NA,NA,p.Gly8Leu,1.922044816,0.023447451,2.1600000000000007e-05,-1.922044816 +urn:mavedb:00000041-a-1#1168,NA,NA,p.Gly8Ile,1.6261237730000002,7.900000000000001e-11,6.7000000000000005e-21,-1.6261237730000002 +urn:mavedb:00000041-a-1#1169,NA,NA,p.Gly8Gln,1.743005092,0.377676726,3.3e-06,-1.743005092 +urn:mavedb:00000041-a-1#1170,NA,NA,p.Gly8Asp,0.842110513,2.07e-42,1.4899999999999992e-82,-0.842110513 +urn:mavedb:00000041-a-1#1171,NA,NA,p.Gly8Asn,1.288777188,1.46e-10,2.16e-20,-1.288777188 +urn:mavedb:00000041-a-1#1172,NA,NA,p.Gly8Arg,1.555680625,1.99e-06,1.54e-12,-1.555680625 +urn:mavedb:00000041-a-1#1173,NA,NA,p.Gly8Ala,1.183208828,1.33e-07,1.03e-14,-1.183208828 +urn:mavedb:00000041-a-1#1174,NA,NA,p.Glu244Arg,0.460420506,7.65e-36,1.0399999999999999e-69,-0.460420506 +urn:mavedb:00000041-a-1#1175,NA,NA,p.Glu244Ala,0.5403183810000001,1.48e-39,5.71e-77,-0.5403183810000001 +urn:mavedb:00000041-a-1#1176,NA,NA,p.Glu239Ter,1.565456761,9.75e-13,1.3999999999999999e-24,-1.565456761 +urn:mavedb:00000041-a-1#1177,NA,NA,p.Glu239Asp,1.052676607,0.391651851,0.0,-1.052676607 +urn:mavedb:00000041-a-1#1178,NA,NA,p.Glu238Val,0.888207183,0.354424515,2.78e-17,-0.888207183 +urn:mavedb:00000041-a-1#1179,NA,NA,p.Glu238Ter,1.6290600990000002,5.44e-08,1.79e-15,-1.6290600990000002 +urn:mavedb:00000041-a-1#1180,NA,NA,p.Glu236Ter,1.497610204,4.2500000000000005e-18,5.429999999999999e-35,-1.497610204 +urn:mavedb:00000041-a-1#1181,NA,NA,p.Glu223Ter,1.594870253,6.78e-07,2.07e-13,-1.594870253 +urn:mavedb:00000041-a-1#1182,NA,NA,p.Glu220Val,0.460548654,0.123448481,0.000106206,-0.460548654 +urn:mavedb:00000041-a-1#1183,NA,NA,p.Glu220Pro,0.6518235379999999,3.2200000000000004e-24,5.999999999999999e-47,-0.6518235379999999 +urn:mavedb:00000041-a-1#1184,NA,NA,p.Glu220Leu,0.592834651,2.87e-32,1.0499999999999993e-62,-0.592834651 +urn:mavedb:00000041-a-1#1185,NA,NA,p.Glu210Ter,1.56007713,9.71e-11,9.93e-21,-1.56007713 +urn:mavedb:00000041-a-1#1186,NA,NA,p.Glu210Met,0.756173578,2.38e-06,1.95e-12,-0.756173578 +urn:mavedb:00000041-a-1#1187,NA,NA,p.Glu210Leu,0.6494771229999999,7.34e-11,5.47e-21,-0.6494771229999999 +urn:mavedb:00000041-a-1#1188,NA,NA,p.Glu210Gly,0.648961224,0.281199486,2.64e-16,-0.648961224 +urn:mavedb:00000041-a-1#1189,NA,NA,p.Glu204Gly,1.013019755,0.369997004,0.0,-1.013019755 +urn:mavedb:00000041-a-1#1190,NA,NA,p.Glu188Val,1.7578885119999998,0.002187306,2.84e-07,-1.7578885119999998 +urn:mavedb:00000041-a-1#1191,NA,NA,p.Glu188Thr,1.544836086,2.26e-10,5.019999999999999e-20,-1.544836086 +urn:mavedb:00000041-a-1#1192,NA,NA,p.Glu188Ser,1.499108391,9.73e-12,1.18e-22,-1.499108391 +urn:mavedb:00000041-a-1#1193,NA,NA,p.Glu188Pro,1.672832474,0.000363554,1.79e-08,-1.672832474 +urn:mavedb:00000041-a-1#1194,NA,NA,p.Glu188Phe,1.441489855,1.1e-09,1.05e-18,-1.441489855 +urn:mavedb:00000041-a-1#1195,NA,NA,p.Glu188Met,1.551140115,4.78e-05,5.170000000000001e-10,-1.551140115 +urn:mavedb:00000041-a-1#1196,NA,NA,p.Glu188Leu,1.539264739,1.26e-14,3.07e-28,-1.539264739 +urn:mavedb:00000041-a-1#1197,NA,NA,p.Glu188Gly,1.479415489,2.28e-09,4.2500000000000005e-18,-1.479415489 +urn:mavedb:00000041-a-1#1198,NA,NA,p.Glu188Gln,1.660227679,1.53e-11,2.83e-22,-1.660227679 +urn:mavedb:00000041-a-1#1199,NA,NA,p.Glu188Cys,1.620827095,6.26e-05,8.400000000000002e-10,-1.620827095 +urn:mavedb:00000041-a-1#1200,NA,NA,p.Glu188Arg,1.5166656,0.307676539,4.83e-05,-1.5166656 +urn:mavedb:00000041-a-1#1201,NA,NA,p.Glu166Val,1.694257539,4.38e-08,1.18e-15,-1.694257539 +urn:mavedb:00000041-a-1#1202,NA,NA,p.Glu166Tyr,1.386626533,1.06e-09,9.67e-19,-1.386626533 +urn:mavedb:00000041-a-1#1203,NA,NA,p.Glu166Thr,1.164651175,7.13e-10,4.570000000000001e-19,-1.164651175 +urn:mavedb:00000041-a-1#1204,NA,NA,p.Glu166Phe,1.889950412,5.38e-08,1.75e-15,-1.889950412 +urn:mavedb:00000041-a-1#1205,NA,NA,p.Glu166Leu,1.525279385,2.18e-10,4.68e-20,-1.525279385 +urn:mavedb:00000041-a-1#1206,NA,NA,p.Glu166His,1.088619022,1.1099999999999998e-88,2.899999999999998e-173,-1.088619022 +urn:mavedb:00000041-a-1#1207,NA,NA,p.Glu166Gly,1.122317968,3.13e-38,2.3e-74,-1.122317968 +urn:mavedb:00000041-a-1#1208,NA,NA,p.Glu149Ter,1.613008442,1.85e-13,5.58e-26,-1.613008442 +urn:mavedb:00000041-a-1#1209,NA,NA,p.Glu149Ser,0.6015892429999999,8.080000000000001e-11,6.27e-21,-0.6015892429999999 +urn:mavedb:00000041-a-1#1210,NA,NA,p.Glu149Pro,1.019415517,6.1600000000000015e-22,1.74e-42,-1.019415517 +urn:mavedb:00000041-a-1#1211,NA,NA,p.Glu149Phe,0.504011653,0.040246711,6.879999999999999e-05,-0.504011653 +urn:mavedb:00000041-a-1#1212,NA,NA,p.Glu149Lys,0.993334143,8.999999999999998e-32,1.0199999999999995e-61,-0.993334143 +urn:mavedb:00000041-a-1#1213,NA,NA,p.Glu149Asp,0.8093625790000001,9.840000000000002e-25,5.99e-48,-0.8093625790000001 +urn:mavedb:00000041-a-1#1214,NA,NA,p.Glu149Asn,0.906088411,1.6200000000000002e-12,3.62e-24,-0.906088411 +urn:mavedb:00000041-a-1#1215,NA,NA,p.Glu149Arg,1.359547624,3.94e-10,1.4e-19,-1.359547624 +urn:mavedb:00000041-a-1#1216,NA,NA,p.Glu146Tyr,1.032928487,2.2599999999999998e-52,4.469999999999997e-102,-1.032928487 +urn:mavedb:00000041-a-1#1218,NA,NA,p.Glu146Gly,1.047290665,0.202603857,2.82e-09,-1.047290665 +urn:mavedb:00000041-a-1#1219,NA,NA,p.Glu146Asp,0.698269562,1.679999999999999e-67,9.909999999999994e-132,-0.698269562 +urn:mavedb:00000041-a-1#1220,NA,NA,p.Glu112Pro,0.913450838,2.43e-07,2.94e-14,-0.913450838 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+urn:mavedb:00000041-a-1#1241,NA,NA,p.Glu44Arg,1.515703295,2.27e-12,7.13e-24,-1.515703295 +urn:mavedb:00000041-a-1#1242,NA,NA,p.Glu44Ala,1.589528884,4.83e-08,1.42e-15,-1.589528884 +urn:mavedb:00000041-a-1#1243,NA,NA,p.Glu39Pro,0.642643049,8.540000000000001e-29,6.85e-56,-0.642643049 +urn:mavedb:00000041-a-1#1244,NA,NA,p.Glu14Pro,1.6022937,6.31e-16,9.07e-31,-1.6022937 +urn:mavedb:00000041-a-1#1245,NA,NA,p.Glu14Gly,1.422714175,2.91e-18,2.57e-35,-1.422714175 +urn:mavedb:00000041-a-1#1246,NA,NA,p.Glu14Asp,0.786443635,6.17e-06,1.25e-11,-0.786443635 +urn:mavedb:00000041-a-1#1247,NA,NA,p.Glu14Ala,0.912725038,1.1699999999999999e-55,1.5899999999999992e-108,-0.912725038 +urn:mavedb:00000041-a-1#1248,NA,NA,p.Gln247Met,1.3632009880000002,0.29388299,5.28e-08,-1.3632009880000002 +urn:mavedb:00000041-a-1#1249,NA,NA,p.Gln231Ter,1.602724337,1.26e-08,1.11e-16,-1.602724337 +urn:mavedb:00000041-a-1#1250,NA,NA,p.Gln231Pro,1.014590361,1.2e-16,3.57e-32,-1.014590361 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+urn:mavedb:00000041-a-1#1846,NA,NA,p.Thr24Trp,-1.121049943,7.29e-26,3.7999999999999994e-50,1.121049943 +urn:mavedb:00000041-a-1#1847,NA,NA,p.Thr24Lys,-0.778232659,2.2e-06,1.73e-12,0.778232659 +urn:mavedb:00000041-a-1#1848,NA,NA,p.Thr24Gly,-1.109158137,1.2499999999999999e-31,2e-61,1.109158137 +urn:mavedb:00000041-a-1#1849,NA,NA,p.Thr24Asp,-1.123706167,4.77e-21,9.79e-41,1.123706167 +urn:mavedb:00000041-a-1#1850,NA,NA,p.Thr24Arg,-0.905411251,5.52e-46,1.4899999999999992e-89,0.905411251 +urn:mavedb:00000041-a-1#1851,NA,NA,p.Thr23Val,-0.69971689,0.279866249,0.0,0.69971689 +urn:mavedb:00000041-a-1#1852,NA,NA,p.Thr23Tyr,-0.8748553990000001,1.55e-24,1.47e-47,0.8748553990000001 +urn:mavedb:00000041-a-1#1853,NA,NA,p.Thr23Trp,-1.306271179,4.55e-51,1.599999999999999e-99,1.306271179 +urn:mavedb:00000041-a-1#1855,NA,NA,p.Val195Asn,-0.512528092,2.48e-26,4.2899999999999986e-51,0.512528092 +urn:mavedb:00000041-a-1#1856,NA,NA,p.Val195Arg,-0.229776324,0.6679303289999999,1.31e-12,0.229776324 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+urn:mavedb:00000041-a-1#1887,NA,NA,p.Val63Tyr,0.238196677,5.27e-47,1.3699999999999992e-91,-0.238196677 +urn:mavedb:00000041-a-1#1888,NA,NA,p.Val63Ile,0.228663886,0.140229535,8.590000000000001e-09,-0.228663886 +urn:mavedb:00000041-a-1#1889,NA,NA,p.Val63His,0.22544948,0.258020415,3.71e-09,-0.22544948 +urn:mavedb:00000041-a-1#1890,NA,NA,p.Val63Ala,0.113630816,1.1599999999999997e-29,1.3199999999999995e-57,-0.113630816 +urn:mavedb:00000041-a-1#1891,NA,NA,p.Val62Thr,-0.10551622,0.35641933299999995,0.0,0.10551622 +urn:mavedb:00000041-a-1#1892,NA,NA,p.Val62Leu,-0.32176356100000003,1.35e-05,5.09e-11,0.32176356100000003 +urn:mavedb:00000041-a-1#1893,NA,NA,p.Val62Glu,-0.036184307,0.000186993,5.03e-09,0.036184307 +urn:mavedb:00000041-a-1#1894,NA,NA,p.Val62Gln,0.42084135,0.210419393,0.0,-0.42084135 +urn:mavedb:00000041-a-1#1895,NA,NA,p.Val57Tyr,-0.040636209,1.87e-34,5.579999999999998e-67,0.040636209 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+urn:mavedb:00000041-a-1#1906,NA,NA,p.Val47Thr,-0.135552576,0.304869436,1.39e-17,0.135552576 +urn:mavedb:00000041-a-1#1907,NA,NA,p.Val47Cys,0.14693884699999998,1.0700000000000002e-20,4.3e-40,-0.14693884699999998 +urn:mavedb:00000041-a-1#1908,NA,NA,p.Val26Tyr,0.397891436,0.348619969,4.1600000000000007e-17,-0.397891436 +urn:mavedb:00000041-a-1#1909,NA,NA,p.Val26Thr,-0.588189648,0.252264545,1.39e-17,0.588189648 +urn:mavedb:00000041-a-1#1910,NA,NA,p.Val26Ser,-0.29834667800000003,2.74e-44,2.9399999999999984e-86,0.29834667800000003 +urn:mavedb:00000041-a-1#1911,NA,NA,p.Val26Phe,0.127256342,0.690445663,0.0,-0.127256342 +urn:mavedb:00000041-a-1#1912,NA,NA,p.Val26Met,0.154634316,0.158721677,0.001319423,-0.154634316 +urn:mavedb:00000041-a-1#1913,NA,NA,p.Val26Gly,0.321940598,1.32e-16,4.08e-32,-0.321940598 +urn:mavedb:00000041-a-1#1914,NA,NA,p.Val26Arg,0.163616612,5.04e-05,5.37e-10,-0.163616612 +urn:mavedb:00000041-a-1#1915,NA,NA,p.Val26Ala,0.229535138,7.08e-12,6.400000000000001e-23,-0.229535138 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+urn:mavedb:00000041-a-1#1926,NA,NA,p.Tyr245Ala,0.153554177,0.261391558,1.39e-17,-0.153554177 +urn:mavedb:00000041-a-1#1927,NA,NA,p.Tyr213Phe,0.192359081,1.01e-36,1.9999999999999994e-71,-0.192359081 +urn:mavedb:00000041-a-1#1928,NA,NA,p.Tyr213Met,0.174664257,4.959999999999999e-42,7.959999999999997e-82,-0.174664257 +urn:mavedb:00000041-a-1#1929,NA,NA,p.Tyr213Leu,0.12939092,6.28e-06,7.61e-12,-0.12939092 +urn:mavedb:00000041-a-1#1930,NA,NA,p.Tyr170Val,0.42825846,3.8099999999999975e-130,1.3899999999999985e-254,-0.42825846 +urn:mavedb:00000041-a-1#1931,NA,NA,p.Tyr170Trp,-0.138483194,6.58e-15,8.14e-29,0.138483194 +urn:mavedb:00000041-a-1#1932,NA,NA,p.Tyr170Thr,0.412559939,0.016903446000000003,1.76e-05,-0.412559939 +urn:mavedb:00000041-a-1#1933,NA,NA,p.Tyr170Phe,0.307806265,0.00360686,1.17e-07,-0.307806265 +urn:mavedb:00000041-a-1#1934,NA,NA,p.Tyr170Met,0.146525311,0.08875798800000001,0.0,-0.146525311 +urn:mavedb:00000041-a-1#1935,NA,NA,p.Tyr170Lys,0.197379213,0.133460515,7.15e-15,-0.197379213 +urn:mavedb:00000041-a-1#1936,NA,NA,p.Tyr170Leu,0.43493404,0.081754903,1.26e-05,-0.43493404 +urn:mavedb:00000041-a-1#1937,NA,NA,p.Tyr170Ile,0.190412181,8.000000000000001e-24,3.39e-46,-0.190412181 +urn:mavedb:00000041-a-1#1938,NA,NA,p.Tyr170Gln,0.216193021,2.13e-29,4.319999999999999e-57,-0.216193021 +urn:mavedb:00000041-a-1#1939,NA,NA,p.Tyr170Cys,0.34817170700000005,0.318416188,2.2800000000000004e-13,-0.34817170700000005 +urn:mavedb:00000041-a-1#1940,NA,NA,p.Tyr170Asp,0.312523197,4.53e-08,1.1699999999999999e-15,-0.312523197 +urn:mavedb:00000041-a-1#1941,NA,NA,p.Tyr170Arg,0.106058861,2.55e-14,1.1e-27,-0.106058861 +urn:mavedb:00000041-a-1#1942,NA,NA,p.Tyr116Thr,-0.287294005,1.03e-108,1.509999999999999e-212,0.287294005 +urn:mavedb:00000041-a-1#1943,NA,NA,p.Tyr116Met,0.217406508,2.31e-20,1.97e-39,-0.217406508 +urn:mavedb:00000041-a-1#1944,NA,NA,p.Tyr116Cys,-0.451350287,4.65e-20,7.82e-39,0.451350287 +urn:mavedb:00000041-a-1#1945,NA,NA,p.Tyr116Ala,-0.39802271,0.492877786,1.11e-16,0.39802271 +urn:mavedb:00000041-a-1#1946,NA,NA,p.Tyr110Trp,-0.186475427,0.384707434,0.0,0.186475427 +urn:mavedb:00000041-a-1#1952,NA,NA,p.Tyr91Ile,0.414133293,3.9099999999999994e-56,1.8499999999999997e-109,-0.414133293 +urn:mavedb:00000041-a-1#1953,NA,NA,p.Tyr91Gly,0.252657244,1.39e-47,1.0499999999999996e-92,-0.252657244 +urn:mavedb:00000041-a-1#1954,NA,NA,p.Tyr91Asp,-0.234145562,0.948610716,5.549999999999998e-16,0.234145562 +urn:mavedb:00000041-a-1#1955,NA,NA,p.Tyr91Ala,0.300717209,5.95e-20,1.26e-38,-0.300717209 +urn:mavedb:00000041-a-1#1956,NA,NA,p.Tyr74Asn,-0.450639909,0.00048649,2.65e-08,0.450639909 +urn:mavedb:00000041-a-1#1957,NA,NA,p.Tyr69Phe,-0.3751851470000001,0.212032613,7.540000000000002e-07,0.3751851470000001 +urn:mavedb:00000041-a-1#1958,NA,NA,p.Tyr69Met,0.167107224,4.63e-27,1.6999999999999993e-52,-0.167107224 +urn:mavedb:00000041-a-1#1959,NA,NA,p.Tyr69His,0.097390715,1.43e-59,3.4399999999999983e-116,-0.097390715 +urn:mavedb:00000041-a-1#1960,NA,NA,p.Tyr69Glu,0.40479018,0.175348741,0.0,-0.40479018 +urn:mavedb:00000041-a-1#1961,NA,NA,p.Tyr60Val,-0.605543638,7.990000000000002e-07,2.8800000000000004e-13,0.605543638 +urn:mavedb:00000041-a-1#1962,NA,NA,p.Tyr60Trp,0.017146953,0.621752596,1.67e-16,-0.017146953 +urn:mavedb:00000041-a-1#1963,NA,NA,p.Tyr60Thr,-0.425615533,0.739496862,0.0,0.425615533 +urn:mavedb:00000041-a-1#1964,NA,NA,p.Tyr60Ser,0.241579684,2.78e-12,1.06e-23,-0.241579684 +urn:mavedb:00000041-a-1#1965,NA,NA,p.Tyr60Phe,-0.232689781,3.98e-13,2.34e-25,0.232689781 +urn:mavedb:00000041-a-1#1966,NA,NA,p.Tyr60Met,-0.305788252,2.58e-07,2.82e-14,0.305788252 +urn:mavedb:00000041-a-1#1967,NA,NA,p.Tyr60Leu,-0.57332111,9.620000000000002e-41,2.709999999999999e-79,0.57332111 +urn:mavedb:00000041-a-1#1968,NA,NA,p.Tyr60His,-0.226656535,3.8699999999999985e-37,3.079999999999999e-72,0.226656535 +urn:mavedb:00000041-a-1#1969,NA,NA,p.Tyr60Gly,-0.198881759,0.0,0.0,0.198881759 +urn:mavedb:00000041-a-1#1970,NA,NA,p.Tyr60Glu,-0.419353767,1.08e-15,2.5199999999999997e-30,0.419353767 +urn:mavedb:00000041-a-1#1971,NA,NA,p.Tyr60Cys,-0.172684907,0.125583017,5.27e-05,0.172684907 +urn:mavedb:00000041-a-1#1972,NA,NA,p.Tyr60Asn,-0.115363756,0.242782893,1.39e-17,0.115363756 +urn:mavedb:00000041-a-1#1973,NA,NA,p.Tyr60Ala,-0.286369396,1.3699999999999996e-21,7.75e-42,0.286369396 +urn:mavedb:00000041-a-1#1974,NA,NA,p.Trp233Thr,0.293493293,5.959999999999998e-65,9.279999999999994e-127,-0.293493293 +urn:mavedb:00000041-a-1#1976,NA,NA,p.Trp233Glu,-0.023433818,3.69e-18,3.72e-35,0.023433818 +urn:mavedb:00000041-a-1#1977,NA,NA,p.Trp233Gln,0.164967008,5.04e-18,7.379999999999998e-35,-0.164967008 +urn:mavedb:00000041-a-1#1978,NA,NA,p.Trp233Cys,0.360688803,2.3999999999999995e-39,1.489999999999999e-76,-0.360688803 +urn:mavedb:00000041-a-1#1979,NA,NA,p.Trp233Asn,0.094450168,5.1599999999999986e-77,2.1799999999999988e-150,-0.094450168 +urn:mavedb:00000041-a-1#1980,NA,NA,p.Trp180Tyr,0.16900337399999998,0.5174606310000001,0.0,-0.16900337399999998 +urn:mavedb:00000041-a-1#1981,NA,NA,p.Trp180Phe,-0.08661775099999999,1.79e-24,1.8100000000000002e-47,0.08661775099999999 +urn:mavedb:00000041-a-1#1982,NA,NA,p.Trp20Tyr,-0.36026222700000005,1.0999999999999999e-44,5.069999999999998e-87,0.36026222700000005 +urn:mavedb:00000041-a-1#1983,NA,NA,p.Trp20Ser,0.073980829,7.27e-14,8.970000000000001e-27,-0.073980829 +urn:mavedb:00000041-a-1#1984,NA,NA,p.Trp20Pro,0.138279768,5e-38,5.5399999999999976e-74,-0.138279768 +urn:mavedb:00000041-a-1#1985,NA,NA,p.Trp20Phe,0.09153476,0.047792982000000005,4.34e-19,-0.09153476 +urn:mavedb:00000041-a-1#1986,NA,NA,p.Trp20Met,-0.493769423,1.5e-05,6.62e-11,0.493769423 +urn:mavedb:00000041-a-1#1987,NA,NA,p.Trp20Leu,-0.339601266,4.769999999999999e-28,1.9899999999999997e-54,0.339601266 +urn:mavedb:00000041-a-1#1988,NA,NA,p.Trp20Gly,-0.444607733,0.306285249,3.17e-07,0.444607733 +urn:mavedb:00000041-a-1#1989,NA,NA,p.Trp20Ala,-0.220290159,2.31e-47,2.8899999999999995e-92,0.220290159 +urn:mavedb:00000041-a-1#1990,NA,NA,p.Thr242Ser,-0.244430753,9.65e-26,6.16e-50,0.244430753 +urn:mavedb:00000041-a-1#1991,NA,NA,p.Thr242Cys,0.049357862,1.29e-12,2.5699999999999997e-24,-0.049357862 +urn:mavedb:00000041-a-1#1992,NA,NA,p.Thr242Arg,-0.239209384,0.166461689,1.39e-17,0.239209384 +urn:mavedb:00000041-a-1#1993,NA,NA,p.Thr242Ala,-0.265970936,4.88e-08,1.4400000000000001e-15,0.265970936 +urn:mavedb:00000041-a-1#1994,NA,NA,p.Thr191Ser,0.181997187,0.157092671,6.77e-07,-0.181997187 +urn:mavedb:00000041-a-1#1995,NA,NA,p.Thr191Phe,-0.097503265,0.56139369,1.11e-16,0.097503265 +urn:mavedb:00000041-a-1#1996,NA,NA,p.Thr191Met,0.32802844800000003,1.4699999999999995e-63,4.9299999999999966e-124,-0.32802844800000003 +urn:mavedb:00000041-a-1#1997,NA,NA,p.Thr191Leu,-0.089945516,0.241285539,0.0,0.089945516 +urn:mavedb:00000041-a-1#1998,NA,NA,p.Thr191Gly,-0.134010994,5.429999999999997e-54,2.9099999999999996e-105,0.134010994 +urn:mavedb:00000041-a-1#1999,NA,NA,p.Thr191Glu,0.393219481,7.059999999999998e-19,1.52e-36,-0.393219481 +urn:mavedb:00000041-a-1#2000,NA,NA,p.Thr191Gln,0.25256210100000004,6.5900000000000004e-31,4.94e-60,-0.25256210100000004 +urn:mavedb:00000041-a-1#2001,NA,NA,p.Thr191Asn,0.028974462000000006,6.94e-08,2.75e-15,-0.028974462000000006 +urn:mavedb:00000041-a-1#2002,NA,NA,p.Thr191Ala,0.133894527,1.04e-29,1.0799999999999998e-57,-0.133894527 +urn:mavedb:00000041-a-1#2003,NA,NA,p.Thr190Cys,-0.504149001,1.93e-11,4.549999999999998e-22,0.504149001 +urn:mavedb:00000041-a-1#2004,NA,NA,p.Thr190Ala,-0.101620614,0.219556955,0.0,0.101620614 +urn:mavedb:00000041-a-1#2005,NA,NA,p.Thr187Val,0.008422606,9.42e-16,1.77e-30,-0.008422606 +urn:mavedb:00000041-a-1#2006,NA,NA,p.Thr187Met,-0.056760059,1.71e-11,3.1599999999999997e-22,0.056760059 +urn:mavedb:00000041-a-1#2007,NA,NA,p.Thr187Ile,0.090349729,1.5099999999999996e-40,6.089999999999998e-79,-0.090349729 +urn:mavedb:00000041-a-1#2008,NA,NA,p.Thr187His,0.307031973,0.634800526,0.0,-0.307031973 +urn:mavedb:00000041-a-1#2009,NA,NA,p.Thr187Gln,0.13320116699999998,0.216863422,2.98e-16,-0.13320116699999998 +urn:mavedb:00000041-a-1#2010,NA,NA,p.Thr187Cys,0.35379140600000003,3.2599999999999996e-53,9.639999999999995e-104,-0.35379140600000003 +urn:mavedb:00000041-a-1#2011,NA,NA,p.Thr187Asp,0.33704012200000005,6.1e-21,1.4799999999999999e-40,-0.33704012200000005 +urn:mavedb:00000041-a-1#2013,NA,NA,p.Thr187Ala,0.450715659,1.34e-32,2.3599999999999997e-63,-0.450715659 +urn:mavedb:00000041-a-1#2014,NA,NA,p.Thr174Ser,-0.291057986,4.8600000000000005e-08,1.21e-15,0.291057986 +urn:mavedb:00000041-a-1#2015,NA,NA,p.Thr174Lys,-0.613219645,0.157328092,1.7300000000000002e-17,0.613219645 +urn:mavedb:00000041-a-1#2016,NA,NA,p.Thr174His,-0.548807002,1.259999999999999e-99,9.999999999999991e-195,0.548807002 +urn:mavedb:00000041-a-1#2017,NA,NA,p.Thr174Gly,0.081343255,0.422938519,8.329999999999998e-17,-0.081343255 +urn:mavedb:00000041-a-1#2018,NA,NA,p.Thr174Cys,-0.406059104,1.08e-23,6.41e-46,0.406059104 +urn:mavedb:00000041-a-1#2019,NA,NA,p.Thr174Asn,-0.392369631,9.97e-18,2.74e-34,0.392369631 +urn:mavedb:00000041-a-1#2020,NA,NA,p.Thr174Ala,-0.063788211,6.31e-14,6.23e-27,0.063788211 +urn:mavedb:00000041-a-1#2021,NA,NA,p.Thr151Tyr,-0.28877328,3.53e-23,6.500000000000001e-45,0.28877328 +urn:mavedb:00000041-a-1#2022,NA,NA,p.Thr151Phe,-0.393576979,0.197782065,2.0800000000000003e-17,0.393576979 +urn:mavedb:00000041-a-1#2023,NA,NA,p.Thr151Met,-0.30268758100000004,5.41e-49,1.769999999999999e-95,0.30268758100000004 +urn:mavedb:00000041-a-1#2024,NA,NA,p.Thr151Gln,-0.478288032,0.118363028,2.32e-09,0.478288032 +urn:mavedb:00000041-a-1#2025,NA,NA,p.Thr151Cys,0.443290946,0.420732235,0.0,-0.443290946 +urn:mavedb:00000041-a-1#2026,NA,NA,p.Thr151Asn,0.114996793,0.217744601,0.0,-0.114996793 +urn:mavedb:00000041-a-1#2027,NA,NA,p.Thr88Val,-0.02886511,0.303520412,4.1600000000000007e-17,0.02886511 +urn:mavedb:00000041-a-1#2028,NA,NA,p.Thr88Tyr,-0.500432338,1.4999999999999998e-28,2.019999999999999e-55,0.500432338 +urn:mavedb:00000041-a-1#2029,NA,NA,p.Thr88Pro,-0.332378918,6.59e-13,6.18e-25,0.332378918 +urn:mavedb:00000041-a-1#2030,NA,NA,p.Thr88Phe,-0.245147363,0.12394764,2.24e-14,0.245147363 +urn:mavedb:00000041-a-1#2031,NA,NA,p.Thr88Met,-0.38614254,4.56e-23,1.07e-44,0.38614254 +urn:mavedb:00000041-a-1#2032,NA,NA,p.Thr88Lys,-0.186366862,0.189736314,1.6e-16,0.186366862 +urn:mavedb:00000041-a-1#2033,NA,NA,p.Thr88Leu,0.049718485,0.306270282,0.0,-0.049718485 +urn:mavedb:00000041-a-1#2034,NA,NA,p.Thr88Ile,-0.167610803,6.85e-07,1.7800000000000002e-13,0.167610803 +urn:mavedb:00000041-a-1#2035,NA,NA,p.Thr88His,-0.366100731,0.074837023,5.4299999999999985e-05,0.366100731 +urn:mavedb:00000041-a-1#2036,NA,NA,p.Thr88Gly,-0.081514629,7.020000000000001e-05,6.18e-10,0.081514629 +urn:mavedb:00000041-a-1#2037,NA,NA,p.Thr88Glu,-0.02230553,4.99e-48,1.3999999999999996e-93,0.02230553 +urn:mavedb:00000041-a-1#2038,NA,NA,p.Thr88Gln,0.090746447,0.003078595,4.24e-08,-0.090746447 +urn:mavedb:00000041-a-1#2039,NA,NA,p.Thr88Cys,-0.335543667,0.115423494,1.04e-09,0.335543667 +urn:mavedb:00000041-a-1#2040,NA,NA,p.Thr88Asn,-0.15526569,9.16e-32,9.969999999999994e-62,0.15526569 +urn:mavedb:00000041-a-1#2041,NA,NA,p.Thr88Arg,-0.108335727,1.01e-15,2.13e-30,0.108335727 +urn:mavedb:00000041-a-1#2042,NA,NA,p.Thr88Ala,-0.476806273,4.03e-07,6.34e-14,0.476806273 +urn:mavedb:00000041-a-1#2044,NA,NA,p.Arg93Ter,1.655836322,4.959999999999999e-10,2.2600000000000004e-19,-1.655836322 +urn:mavedb:00000041-a-1#2045,NA,NA,p.Arg93Ser,0.640640329,4.36e-11,2.08e-21,-0.640640329 +urn:mavedb:00000041-a-1#2046,NA,NA,p.Arg93Pro,0.811061837,1.5e-50,1.6699999999999993e-98,-0.811061837 +urn:mavedb:00000041-a-1#2047,NA,NA,p.Arg93Leu,0.499534301,2.1e-09,3.39e-18,-0.499534301 +urn:mavedb:00000041-a-1#2048,NA,NA,p.Arg93Ile,0.574875284,0.316961325,6.94e-17,-0.574875284 +urn:mavedb:00000041-a-1#2049,NA,NA,p.Arg93His,0.526139424,1.88e-19,1.19e-37,-0.526139424 +urn:mavedb:00000041-a-1#2050,NA,NA,p.Arg93Gly,0.6216350310000001,0.000988812,6.94e-08,-0.6216350310000001 +urn:mavedb:00000041-a-1#2051,NA,NA,p.Arg93Glu,0.927346035,2.39e-14,1.03e-27,-0.927346035 +urn:mavedb:00000041-a-1#2052,NA,NA,p.Arg93Asp,0.90308154,9.07e-20,2.96e-38,-0.90308154 +urn:mavedb:00000041-a-1#2053,NA,NA,p.Arg93Asn,0.6115847520000001,1.87e-18,1.09e-35,-0.6115847520000001 +urn:mavedb:00000041-a-1#2054,NA,NA,p.Arg93Ala,0.660040838,9.4e-12,1.07e-22,-0.660040838 +urn:mavedb:00000041-a-1#2055,NA,NA,p.Arg52Pro,0.493109791,0.189136286,2.4e-14,-0.493109791 +urn:mavedb:00000041-a-1#2056,NA,NA,p.Arg52Leu,0.516536113,5.92e-26,2.4599999999999997e-50,-0.516536113 +urn:mavedb:00000041-a-1#2057,NA,NA,p.Arg25Ter,1.5682468180000002,9.81e-09,6.84e-17,-1.5682468180000002 +urn:mavedb:00000041-a-1#2058,NA,NA,p.Arg2Tyr,0.7044520740000001,0.293273715,0.0,-0.7044520740000001 +urn:mavedb:00000041-a-1#2059,NA,NA,p.Arg2Thr,1.531695125,8.18e-20,2.44e-38,-1.531695125 +urn:mavedb:00000041-a-1#2060,NA,NA,p.Arg2Pro,0.545370615,0.29959998600000004,2.73e-06,-0.545370615 +urn:mavedb:00000041-a-1#2061,NA,NA,p.Ala168Val,1.012076144,1.95e-19,1.3399999999999999e-37,-1.012076144 +urn:mavedb:00000041-a-1#2062,NA,NA,p.Ala168Thr,1.081169168,6.48e-23,2.14e-44,-1.081169168 +urn:mavedb:00000041-a-1#2063,NA,NA,p.Ala168Lys,1.333604521,0.000296025,1.28e-08,-1.333604521 +urn:mavedb:00000041-a-1#2064,NA,NA,p.Ala168Leu,0.936069784,5.899999999999998e-19,1.1499999999999996e-36,-0.936069784 +urn:mavedb:00000041-a-1#2065,NA,NA,p.Ala168Ile,0.705002935,3.599999999999999e-89,3.0299999999999984e-174,-0.705002935 +urn:mavedb:00000041-a-1#2066,NA,NA,p.Ala168Cys,0.5751109839999999,3.58e-06,4.0599999999999985e-12,-0.5751109839999999 +urn:mavedb:00000041-a-1#2067,NA,NA,p.Ala168Arg,1.510047172,2.3100000000000006e-21,2.3499999999999997e-41,-1.510047172 +urn:mavedb:00000041-a-1#2068,NA,NA,p.Ala167Val,1.13024783,0.013007362,1.77e-06,-1.13024783 +urn:mavedb:00000041-a-1#2069,NA,NA,p.Ala164Val,1.624442533,1.76e-09,2.57e-18,-1.624442533 +urn:mavedb:00000041-a-1#2070,NA,NA,p.Ala164Tyr,1.474170103,1.0499999999999999e-21,5.01e-42,-1.474170103 +urn:mavedb:00000041-a-1#2071,NA,NA,p.Ala164Trp,1.571722926,1.59e-11,3.06e-22,-1.571722926 +urn:mavedb:00000041-a-1#2072,NA,NA,p.Ala164Thr,1.4175976469999998,4.96e-14,4.35e-27,-1.4175976469999998 +urn:mavedb:00000041-a-1#2073,NA,NA,p.Ala164Ter,1.591552369,3.77e-12,1.89e-23,-1.591552369 +urn:mavedb:00000041-a-1#2074,NA,NA,p.Ala164Phe,1.495173602,1.56e-11,2.9299999999999997e-22,-1.495173602 +urn:mavedb:00000041-a-1#2075,NA,NA,p.Ala164Met,1.582557372,2.55e-10,6.349999999999999e-20,-1.582557372 +urn:mavedb:00000041-a-1#2076,NA,NA,p.Ala164Lys,1.566627877,1.09e-14,2.3e-28,-1.566627877 +urn:mavedb:00000041-a-1#2077,NA,NA,p.Ala164Leu,1.574300929,2.7300000000000003e-12,1.0199999999999999e-23,-1.574300929 +urn:mavedb:00000041-a-1#2078,NA,NA,p.Ala164Ile,1.635464004,1.31e-11,2.09e-22,-1.635464004 +urn:mavedb:00000041-a-1#2079,NA,NA,p.Ala164His,1.568750299,1.8000000000000004e-12,4.54e-24,-1.568750299 +urn:mavedb:00000041-a-1#2080,NA,NA,p.Ala164Gln,1.601065361,6.83e-14,8.07e-27,-1.601065361 +urn:mavedb:00000041-a-1#2081,NA,NA,p.Ala164Asn,1.589291042,1.59e-12,3.6e-24,-1.589291042 +urn:mavedb:00000041-a-1#2082,NA,NA,p.Ala164Arg,1.534817995,4.96e-12,3.23e-23,-1.534817995 +urn:mavedb:00000041-a-1#2083,NA,NA,p.Ala156Val,1.190927397,2.81e-31,9.49e-61,-1.190927397 +urn:mavedb:00000041-a-1#2084,NA,NA,p.Ala156Tyr,1.04327467,1.7800000000000002e-25,2.14e-49,-1.04327467 +urn:mavedb:00000041-a-1#2085,NA,NA,p.Ala156Trp,1.337100204,1.99e-10,3.93e-20,-1.337100204 +urn:mavedb:00000041-a-1#2086,NA,NA,p.Ala156Ter,1.61507122,0.002967884,3.75e-07,-1.61507122 +urn:mavedb:00000041-a-1#2087,NA,NA,p.Ala156Pro,1.561130608,0.001000667,8.939999999999998e-08,-1.561130608 +urn:mavedb:00000041-a-1#2088,NA,NA,p.Ala156Met,0.806155396,1.9099999999999997e-57,4.969999999999998e-112,-0.806155396 +urn:mavedb:00000041-a-1#2089,NA,NA,p.Ala156Lys,1.181250205,2.1e-18,1.3599999999999998e-35,-1.181250205 +urn:mavedb:00000041-a-1#2090,NA,NA,p.Ala156Leu,1.067984601,1.43e-33,3.089999999999999e-65,-1.067984601 +urn:mavedb:00000041-a-1#2091,NA,NA,p.Ala156Ile,1.232646263,2.1499999999999996e-34,7.599999999999997e-67,-1.232646263 +urn:mavedb:00000041-a-1#2092,NA,NA,p.Ala156His,1.293002237,3.73e-28,1.2399999999999996e-54,-1.293002237 +urn:mavedb:00000041-a-1#2093,NA,NA,p.Ala156Glu,1.151027837,6.9e-13,7.1e-25,-1.151027837 +urn:mavedb:00000041-a-1#2094,NA,NA,p.Ala156Gln,0.7110084320000001,9.06e-10,7.040000000000002e-19,-0.7110084320000001 +urn:mavedb:00000041-a-1#2095,NA,NA,p.Ala156Cys,0.502230292,8.689999999999999e-16,1.5599999999999999e-30,-0.502230292 +urn:mavedb:00000041-a-1#2096,NA,NA,p.Ala156Asp,0.7719731959999999,1.32e-09,1.44e-18,-0.7719731959999999 +urn:mavedb:00000041-a-1#2097,NA,NA,p.Ala156Asn,1.011444943,4.68e-41,6.669999999999998e-80,-1.011444943 +urn:mavedb:00000041-a-1#2098,NA,NA,p.Ala156Arg,1.33755062,5.62e-18,9.22e-35,-1.33755062 +urn:mavedb:00000041-a-1#2099,NA,NA,p.Ala152Val,0.8811781879999999,7.37e-35,9.119999999999999e-68,-0.8811781879999999 +urn:mavedb:00000041-a-1#2100,NA,NA,p.Ala152Tyr,1.448693728,1.04e-09,9.37e-19,-1.448693728 +urn:mavedb:00000041-a-1#2101,NA,NA,p.Ala152Trp,1.293835709,3.98e-26,1.15e-50,-1.293835709 +urn:mavedb:00000041-a-1#2102,NA,NA,p.Ala152Thr,1.288147148,8.849999999999998e-10,6.959999999999999e-19,-1.288147148 +urn:mavedb:00000041-a-1#2103,NA,NA,p.Ala152Ter,1.762278082,6.32e-07,1.8000000000000002e-13,-1.762278082 +urn:mavedb:00000041-a-1#2104,NA,NA,p.Ala152Ser,1.028266076,7.509999999999998e-26,3.929999999999999e-50,-1.028266076 +urn:mavedb:00000041-a-1#2105,NA,NA,p.Ala152Pro,0.979404691,1.17e-13,2.24e-26,-0.979404691 +urn:mavedb:00000041-a-1#2106,NA,NA,p.Ala152Phe,1.338373885,8.12e-17,1.68e-32,-1.338373885 +urn:mavedb:00000041-a-1#2107,NA,NA,p.Ala152Met,0.539124178,8.6e-20,2.62e-38,-0.539124178 +urn:mavedb:00000041-a-1#2108,NA,NA,p.Ala152Lys,1.469281239,5.65e-13,4.8e-25,-1.469281239 +urn:mavedb:00000041-a-1#2109,NA,NA,p.Ala152Leu,1.181767734,7.67e-18,1.7e-34,-1.181767734 +urn:mavedb:00000041-a-1#2110,NA,NA,p.Ala152Ile,1.122944123,5.0399999999999994e-30,2.6899999999999996e-58,-1.122944123 +urn:mavedb:00000041-a-1#2111,NA,NA,p.Ala152His,1.558192061,2.02e-06,1.58e-12,-1.558192061 +urn:mavedb:00000041-a-1#2112,NA,NA,p.Thr35Trp,0.033341431,0.17370174,2.6e-05,-0.033341431 +urn:mavedb:00000041-a-1#2113,NA,NA,p.Thr35Ser,-0.087579824,0.118524494,0.0,0.087579824 +urn:mavedb:00000041-a-1#2114,NA,NA,p.Thr35Pro,-0.075304199,0.030003992,3.3600000000000004e-05,0.075304199 +urn:mavedb:00000041-a-1#2115,NA,NA,p.Thr35Met,-0.043071514000000005,1.1799999999999999e-20,5.3600000000000005e-40,0.043071514000000005 +urn:mavedb:00000041-a-1#2116,NA,NA,p.Thr35His,-0.167349177,0.142671551,3.47e-18,0.167349177 +urn:mavedb:00000041-a-1#2117,NA,NA,p.Thr35Gly,-0.05835011900000001,0.367154279,8.190000000000003e-15,0.05835011900000001 +urn:mavedb:00000041-a-1#2118,NA,NA,p.Thr35Glu,0.119897572,4.7e-15,4.24e-29,-0.119897572 +urn:mavedb:00000041-a-1#2119,NA,NA,p.Thr35Asp,0.45487659,1.11e-36,2.3799999999999996e-71,-0.45487659 +urn:mavedb:00000041-a-1#2120,NA,NA,p.Thr35Ala,-0.34815633700000004,0.348470539,2.78e-17,0.34815633700000004 +urn:mavedb:00000041-a-1#2121,NA,NA,p.Thr30Trp,0.269882941,1.4400000000000005e-25,1.32e-49,-0.269882941 +urn:mavedb:00000041-a-1#2122,NA,NA,p.Thr30His,-0.255851283,2.71e-26,5.309999999999999e-51,0.255851283 +urn:mavedb:00000041-a-1#2123,NA,NA,p.Thr30Gly,-0.463092027,0.001015505,3.3e-08,0.463092027 +urn:mavedb:00000041-a-1#2124,NA,NA,p.Thr30Asn,0.397374696,6.9199999999999994e-40,1.2499999999999993e-77,-0.397374696 +urn:mavedb:00000041-a-1#2125,NA,NA,p.Thr30Arg,-0.124340167,9.57e-05,1.14e-09,0.124340167 +urn:mavedb:00000041-a-1#2126,NA,NA,p.Thr24Tyr,-0.071370135,0.182311257,4.03e-10,0.071370135 +urn:mavedb:00000041-a-1#2127,NA,NA,p.Thr24Ser,-0.565788854,4.4199999999999995e-30,2.0799999999999996e-58,0.565788854 +urn:mavedb:00000041-a-1#2128,NA,NA,p.Thr24Pro,0.064646715,4.94e-06,6.83e-12,-0.064646715 +urn:mavedb:00000041-a-1#2129,NA,NA,p.Thr24Met,0.218590481,0.214010467,0.0,-0.218590481 +urn:mavedb:00000041-a-1#2130,NA,NA,p.Thr24Ile,-0.405388006,0.140678208,1.7300000000000002e-17,0.405388006 +urn:mavedb:00000041-a-1#2131,NA,NA,p.Thr24His,-0.35969878200000005,1.58e-21,1.06e-41,0.35969878200000005 +urn:mavedb:00000041-a-1#2132,NA,NA,p.Thr24Glu,-0.103723701,0.169004823,1.39e-17,0.103723701 +urn:mavedb:00000041-a-1#2133,NA,NA,p.Thr24Gln,-0.03314824,2.77e-14,1.25e-27,0.03314824 +urn:mavedb:00000041-a-1#2138,NA,NA,p.Met100Cys,0.073310576,1.0199999999999996e-55,1.1899999999999999e-108,-0.073310576 +urn:mavedb:00000041-a-1#2139,NA,NA,p.Met75Phe,0.341091191,0.00333437,6.15e-08,-0.341091191 +urn:mavedb:00000041-a-1#2140,NA,NA,p.Met75Lys,0.105362369,1.14e-28,1.19e-55,-0.105362369 +urn:mavedb:00000041-a-1#2141,NA,NA,p.Met17Trp,-0.594526216,0.030247578,6.65e-05,0.594526216 +urn:mavedb:00000041-a-1#2142,NA,NA,p.Met17Ser,-0.064946431,5.32e-21,1.12e-40,0.064946431 +urn:mavedb:00000041-a-1#2143,NA,NA,p.Met17Lys,0.042961277,1.9e-30,3.8199999999999995e-59,-0.042961277 +urn:mavedb:00000041-a-1#2144,NA,NA,p.Met17Leu,-0.435018388,1.6200000000000002e-12,3.63e-24,0.435018388 +urn:mavedb:00000041-a-1#2145,NA,NA,p.Met17His,-0.033243331,1.0499999999999994e-91,3.209999999999999e-179,0.033243331 +urn:mavedb:00000041-a-1#2146,NA,NA,p.Met17Glu,-0.017702225,0.239202096,1.39e-17,0.017702225 +urn:mavedb:00000041-a-1#2147,NA,NA,p.Met17Gln,-0.210590776,0.240814045,0.0,0.210590776 +urn:mavedb:00000041-a-1#2148,NA,NA,p.Met17Cys,-0.102031917,1.8599999999999996e-94,1.279999999999999e-184,0.102031917 +urn:mavedb:00000041-a-1#2149,NA,NA,p.Met17Asn,-0.026059954,3.77e-10,1.1800000000000002e-19,0.026059954 +urn:mavedb:00000041-a-1#2150,NA,NA,p.Met17Ala,-0.128789544,2.54e-22,3.0600000000000003e-43,0.128789544 +urn:mavedb:00000041-a-1#2151,NA,NA,p.Lys235Val,-0.112179608,0.249835536,1.97e-10,0.112179608 +urn:mavedb:00000041-a-1#2152,NA,NA,p.Lys235Tyr,0.199395999,0.32713020800000003,3.16e-15,-0.199395999 +urn:mavedb:00000041-a-1#2153,NA,NA,p.Lys235Thr,-0.474525165,2.96e-69,3.4499999999999983e-135,0.474525165 +urn:mavedb:00000041-a-1#2154,NA,NA,p.Lys235Ser,-0.201848706,0.242323725,0.0,0.201848706 +urn:mavedb:00000041-a-1#2155,NA,NA,p.Lys235His,-0.20006423,0.202125119,0.0,0.20006423 +urn:mavedb:00000041-a-1#2156,NA,NA,p.Lys235Gly,-0.388933858,1.59e-05,6.6e-11,0.388933858 +urn:mavedb:00000041-a-1#2157,NA,NA,p.Lys235Asp,0.02559432,5.85e-20,1.21e-38,-0.02559432 +urn:mavedb:00000041-a-1#2158,NA,NA,p.Lys235Asn,-0.300057024,8.39e-11,7.159999999999999e-21,0.300057024 +urn:mavedb:00000041-a-1#2159,NA,NA,p.Lys192Ala,0.27715886100000003,0.219793985,8.1e-15,-0.27715886100000003 +urn:mavedb:00000041-a-1#2160,NA,NA,p.Lys176Val,0.181275763,1.77e-74,1.939999999999999e-145,-0.181275763 +urn:mavedb:00000041-a-1#2161,NA,NA,p.Lys176Tyr,-0.619629812,7.469999999999996e-121,2.3399999999999975e-236,0.619629812 +urn:mavedb:00000041-a-1#2162,NA,NA,p.Lys176Trp,0.135872175,8.649999999999999e-43,2.5499999999999994e-83,-0.135872175 +urn:mavedb:00000041-a-1#2163,NA,NA,p.Lys176Ser,-0.6281697860000001,1.24e-51,1.2099999999999995e-100,0.6281697860000001 +urn:mavedb:00000041-a-1#2164,NA,NA,p.Lys176Pro,-0.275053904,2.51e-11,6.74e-22,0.275053904 +urn:mavedb:00000041-a-1#2165,NA,NA,p.Lys176Phe,-0.515084761,1.21e-25,9.94e-50,0.515084761 +urn:mavedb:00000041-a-1#2166,NA,NA,p.Lys176Met,-0.066304799,1.4e-14,3.6399999999999996e-28,0.066304799 +urn:mavedb:00000041-a-1#2167,NA,NA,p.Lys176Leu,-0.08517221400000001,0.13235974,0.0,0.08517221400000001 +urn:mavedb:00000041-a-1#2168,NA,NA,p.Lys176His,-0.136432943,5.94e-06,1.04e-11,0.136432943 +urn:mavedb:00000041-a-1#2169,NA,NA,p.Lys176Glu,-0.17152880399999998,3.029999999999999e-121,4.0099999999999967e-237,0.17152880399999998 +urn:mavedb:00000041-a-1#2170,NA,NA,p.Lys176Gln,-0.523585094,7.150000000000001e-16,1.14e-30,0.523585094 +urn:mavedb:00000041-a-1#2171,NA,NA,p.Lys176Cys,-0.027826684,9.79e-05,1.41e-09,0.027826684 +urn:mavedb:00000041-a-1#2172,NA,NA,p.Lys176Asp,-0.328508813,4.610000000000001e-13,3.3000000000000003e-25,0.328508813 +urn:mavedb:00000041-a-1#2173,NA,NA,p.Lys176Arg,-0.219920123,0.570121451,0.0,0.219920123 +urn:mavedb:00000041-a-1#2174,NA,NA,p.Lys161Met,0.328499414,4.320000000000001e-09,1.27e-17,-0.328499414 +urn:mavedb:00000041-a-1#2175,NA,NA,p.Lys157Trp,0.156630557,6.909999999999999e-15,8.729999999999998e-29,-0.156630557 +urn:mavedb:00000041-a-1#2176,NA,NA,p.Lys157Phe,-0.599277319,1.7100000000000008e-13,4.84e-26,0.599277319 +urn:mavedb:00000041-a-1#2177,NA,NA,p.Lys157Met,-0.338013206,1.5199999999999994e-64,5.979999999999997e-126,0.338013206 +urn:mavedb:00000041-a-1#2178,NA,NA,p.Lys157Cys,-0.167077759,4.120000000000001e-13,2.3899999999999997e-25,0.167077759 +urn:mavedb:00000041-a-1#2179,NA,NA,p.Lys157Arg,0.262676525,0.000172775,3.1e-09,-0.262676525 +urn:mavedb:00000041-a-1#2180,NA,NA,p.Lys135Tyr,0.244160482,0.292486288,4.45e-06,-0.244160482 +urn:mavedb:00000041-a-1#2181,NA,NA,p.Lys135Ser,-0.497553271,2.5e-26,4.51e-51,0.497553271 +urn:mavedb:00000041-a-1#2182,NA,NA,p.Lys135Leu,-0.030295552000000007,1.889999999999999e-77,2.959999999999998e-151,0.030295552000000007 +urn:mavedb:00000041-a-1#2183,NA,NA,p.Lys135Ile,0.10728488,0.189001466,6.94e-18,-0.10728488 +urn:mavedb:00000041-a-1#2184,NA,NA,p.Lys135Glu,0.399595036,1.1e-30,1.32e-59,-0.399595036 +urn:mavedb:00000041-a-1#2185,NA,NA,p.Lys135Gln,-0.395783753,0.361534376,2.57e-06,0.395783753 +urn:mavedb:00000041-a-1#2186,NA,NA,p.Lys90His,-0.229631647,2.0399999999999997e-72,2.169999999999999e-141,0.229631647 +urn:mavedb:00000041-a-1#2187,NA,NA,p.Lys85Val,-0.274073876,8.89e-35,1.2699999999999991e-67,0.274073876 +urn:mavedb:00000041-a-1#2188,NA,NA,p.Lys85Tyr,-0.420813762,0.07966448799999999,8.84e-06,0.420813762 +urn:mavedb:00000041-a-1#2189,NA,NA,p.Lys85Trp,-0.512144409,0.008598424,1.99e-06,0.512144409 +urn:mavedb:00000041-a-1#2190,NA,NA,p.Lys85Thr,-0.259521428,2.54e-09,4.84e-18,0.259521428 +urn:mavedb:00000041-a-1#2191,NA,NA,p.Lys85Phe,-0.232016304,2.26e-12,7.27e-24,0.232016304 +urn:mavedb:00000041-a-1#2192,NA,NA,p.Lys85Met,-0.266300242,1.0199999999999999e-21,4.52e-42,0.266300242 +urn:mavedb:00000041-a-1#2193,NA,NA,p.Lys85Leu,0.08680803,2.22e-48,2.819999999999998e-94,-0.08680803 +urn:mavedb:00000041-a-1#2194,NA,NA,p.Lys85Ile,-0.228604668,4.5999999999999986e-36,3.94e-70,0.228604668 +urn:mavedb:00000041-a-1#2195,NA,NA,p.Lys85His,-0.232010874,0.217060147,2.15e-16,0.232010874 +urn:mavedb:00000041-a-1#2196,NA,NA,p.Lys85Gly,0.004399697,1.25e-20,5.62e-40,-0.004399697 +urn:mavedb:00000041-a-1#2197,NA,NA,p.Lys85Glu,-0.244940233,0.166841095,1.0400000000000002e-17,0.244940233 +urn:mavedb:00000041-a-1#2198,NA,NA,p.Lys85Gln,-0.164502291,6.549999999999998e-51,3.0999999999999986e-99,0.164502291 +urn:mavedb:00000041-a-1#2199,NA,NA,p.Lys85Cys,-0.193769481,0.168031178,4.870000000000001e-09,0.193769481 +urn:mavedb:00000041-a-1#2200,NA,NA,p.Lys85Asp,0.005530195,0.341228895,1.39e-17,-0.005530195 +urn:mavedb:00000041-a-1#2201,NA,NA,p.Lys85Asn,-0.087510702,0.06336213,1.1e-07,0.087510702 +urn:mavedb:00000041-a-1#2202,NA,NA,p.Lys85Ala,0.293747202,1.47e-39,5.449999999999998e-77,-0.293747202 +urn:mavedb:00000041-a-1#2203,NA,NA,p.Lys77Val,0.083265958,2.9199999999999998e-31,1.01e-60,-0.083265958 +urn:mavedb:00000041-a-1#2204,NA,NA,p.Lys77Tyr,-0.237926071,6.67e-06,1.4699999999999998e-11,0.237926071 +urn:mavedb:00000041-a-1#2205,NA,NA,p.Lys77Trp,-0.224638252,0.32099864300000003,6.820000000000001e-11,0.224638252 +urn:mavedb:00000041-a-1#2206,NA,NA,p.Lys77Thr,-0.170861464,1.85e-13,5.79e-26,0.170861464 +urn:mavedb:00000041-a-1#2207,NA,NA,p.Lys77Ser,-0.157920897,0.296293909,0.0,0.157920897 +urn:mavedb:00000041-a-1#2208,NA,NA,p.Lys77Phe,0.245127017,0.230337465,6.94e-18,-0.245127017 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+urn:mavedb:00000041-a-1#2218,NA,NA,p.Lys77Ala,-0.151856162,0.16953963,0.0,0.151856162 +urn:mavedb:00000041-a-1#2219,NA,NA,p.Lys55Tyr,0.009128,0.286846826,0.0,-0.009128 +urn:mavedb:00000041-a-1#2220,NA,NA,p.Lys55Thr,-0.40608915,7.439999999999999e-18,1.55e-34,0.40608915 +urn:mavedb:00000041-a-1#2221,NA,NA,p.Lys55Ser,-0.158684641,1.22e-12,2.11e-24,0.158684641 +urn:mavedb:00000041-a-1#2222,NA,NA,p.Lys55Met,0.07811380700000001,0.003117072,4.26e-07,-0.07811380700000001 +urn:mavedb:00000041-a-1#2223,NA,NA,p.Lys55His,-0.480826286,0.320043168,2.62e-14,0.480826286 +urn:mavedb:00000041-a-1#2224,NA,NA,p.Lys55Gly,0.246080247,3.109999999999999e-48,5.199999999999998e-94,-0.246080247 +urn:mavedb:00000041-a-1#2225,NA,NA,p.Lys55Gln,-0.288692029,1.72e-30,3.27e-59,0.288692029 +urn:mavedb:00000041-a-1#2226,NA,NA,p.Lys55Cys,-0.221548374,0.407482438,0.0,0.221548374 +urn:mavedb:00000041-a-1#2227,NA,NA,p.Lys55Arg,-0.269615555,1.72e-25,1.9499999999999997e-49,0.269615555 +urn:mavedb:00000041-a-1#2228,NA,NA,p.Lys55Ala,-0.53209367,0.75489348,2.22e-16,0.53209367 +urn:mavedb:00000041-a-1#2229,NA,NA,p.Lys50Val,-0.377953334,9.54e-33,1.2499999999999995e-63,0.377953334 +urn:mavedb:00000041-a-1#2230,NA,NA,p.Lys50Tyr,-0.292578555,1.59e-38,5.949999999999998e-75,0.292578555 +urn:mavedb:00000041-a-1#2231,NA,NA,p.Lys50Thr,-0.391298884,0.005182849000000001,4.92e-07,0.391298884 +urn:mavedb:00000041-a-1#2232,NA,NA,p.Lys50Ser,-0.124437768,0.236831959,2.0800000000000003e-17,0.124437768 +urn:mavedb:00000041-a-1#2233,NA,NA,p.Lys50Met,-0.462372544,0.267652061,2.16e-14,0.462372544 +urn:mavedb:00000041-a-1#2234,NA,NA,p.Lys50Leu,-0.163115857,0.346769468,1.39e-17,0.163115857 +urn:mavedb:00000041-a-1#2235,NA,NA,p.Lys50Ile,-0.496893334,2.76e-16,1.7699999999999994e-31,0.496893334 +urn:mavedb:00000041-a-1#2236,NA,NA,p.Lys50Gln,-0.100180448,1.74e-05,7.390000000000001e-11,0.100180448 +urn:mavedb:00000041-a-1#2237,NA,NA,p.Lys50Cys,-0.5894840020000001,1.4899999999999997e-30,2.5499999999999994e-59,0.5894840020000001 +urn:mavedb:00000041-a-1#2238,NA,NA,p.Lys50Asp,-0.588544678,1.55e-05,5.59e-11,0.588544678 +urn:mavedb:00000041-a-1#2239,NA,NA,p.Lys50Asn,-0.191305782,0.00115187,5.67e-08,0.191305782 +urn:mavedb:00000041-a-1#2240,NA,NA,p.Lys50Arg,-0.022842891,0.202542439,0.0,0.022842891 +urn:mavedb:00000041-a-1#2241,NA,NA,p.Lys50Ala,-0.339585744,1.8199999999999998e-44,1.3999999999999993e-86,0.339585744 +urn:mavedb:00000041-a-1#2242,NA,NA,p.Lys49Met,0.4302831070000001,4.3499999999999997e-39,4.589999999999999e-76,-0.4302831070000001 +urn:mavedb:00000041-a-1#2243,NA,NA,p.Lys32Val,0.381188418,1.31e-38,3.9599999999999986e-75,-0.381188418 +urn:mavedb:00000041-a-1#2244,NA,NA,p.Lys32Arg,0.379407743,8.01e-11,6.3200000000000005e-21,-0.379407743 +urn:mavedb:00000041-a-1#2245,NA,NA,p.Lys6Ser,-0.44030568,0.001763182,8.939999999999998e-08,0.44030568 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+urn:mavedb:00000041-a-1#2315,NA,NA,p.Leu92Thr,-0.104935413,5.29e-12,3.3500000000000004e-23,0.104935413 +urn:mavedb:00000041-a-1#2316,NA,NA,p.Leu92Ser,-0.34699505700000005,2.24e-18,1.49e-35,0.34699505700000005 +urn:mavedb:00000041-a-1#2317,NA,NA,p.Leu92Phe,-0.296028712,1.5299999999999999e-71,1.0699999999999993e-139,0.296028712 +urn:mavedb:00000041-a-1#2318,NA,NA,p.Leu92Ile,-0.592513749,3.0400000000000004e-20,3.46e-39,0.592513749 +urn:mavedb:00000041-a-1#2320,NA,NA,p.Leu92Glu,0.118017261,0.184764393,3.4399999999999995e-13,-0.118017261 +urn:mavedb:00000041-a-1#2321,NA,NA,p.Leu92Arg,0.216521215,0.08965142,1.42e-07,-0.216521215 +urn:mavedb:00000041-a-1#2322,NA,NA,p.Leu92Ala,-0.20358998,1.87e-09,2.69e-18,0.20358998 +urn:mavedb:00000041-a-1#2323,NA,NA,p.Leu84Val,-0.287263165,0.227161475,0.0,0.287263165 +urn:mavedb:00000041-a-1#2324,NA,NA,p.Leu84Ser,-0.07214134,0.00600865,6.57e-07,0.07214134 +urn:mavedb:00000041-a-1#2325,NA,NA,p.Leu84Phe,0.35903018,0.016980406,1.64e-05,-0.35903018 +urn:mavedb:00000041-a-1#2326,NA,NA,p.Leu84Ile,0.00686336,1.84e-09,2.63e-18,-0.00686336 +urn:mavedb:00000041-a-1#2327,NA,NA,p.Leu84Cys,-0.558771673,3.3599999999999997e-26,8.07e-51,0.558771673 +urn:mavedb:00000041-a-1#2328,NA,NA,p.Thr23Arg,-0.658189436,0.515507641,5.55e-17,0.658189436 +urn:mavedb:00000041-a-1#2329,NA,NA,p.Ser181Met,-0.677494154,8.760000000000001e-38,1.68e-73,0.677494154 +urn:mavedb:00000041-a-1#2330,NA,NA,p.Ser106Phe,-0.648274131,2.61e-21,3.08e-41,0.648274131 +urn:mavedb:00000041-a-1#2331,NA,NA,p.Ser106His,-0.8004766240000001,5.7e-27,2.5499999999999985e-52,0.8004766240000001 +urn:mavedb:00000041-a-1#2332,NA,NA,p.Ser106Cys,-0.825019023,1.82e-07,1.61e-14,0.825019023 +urn:mavedb:00000041-a-1#2333,NA,NA,p.Ser106Asn,-0.838711772,0.401936979,7.46e-06,0.838711772 +urn:mavedb:00000041-a-1#2334,NA,NA,p.Ser106Arg,-0.6377179239999999,9.62e-11,9.41e-21,0.6377179239999999 +urn:mavedb:00000041-a-1#2335,NA,NA,p.Ser79Asp,-1.951765631,1.1599999999999998e-22,7.11e-44,1.951765631 +urn:mavedb:00000041-a-1#2336,NA,NA,p.Ser79Asn,-1.182895335,2.2799999999999996e-57,7.189999999999997e-112,1.182895335 +urn:mavedb:00000041-a-1#2337,NA,NA,p.Ser76Leu,-1.102569359,1.36e-45,8.64e-89,1.102569359 +urn:mavedb:00000041-a-1#2338,NA,NA,p.Ser76Gln,-0.91363189,0.966842068,0.0,0.91363189 +urn:mavedb:00000041-a-1#2339,NA,NA,p.Ser76Arg,-1.655501196,7.35e-17,1.4099999999999995e-32,1.655501196 +urn:mavedb:00000041-a-1#2340,NA,NA,p.Pro237Tyr,-0.848718819,2.6199999999999998e-39,1.8e-76,0.848718819 +urn:mavedb:00000041-a-1#2341,NA,NA,p.Pro237Trp,-0.8265003609999999,2.01e-14,7.669999999999998e-28,0.8265003609999999 +urn:mavedb:00000041-a-1#2342,NA,NA,p.Pro237Phe,-0.846564395,0.000107562,2.33e-09,0.846564395 +urn:mavedb:00000041-a-1#2343,NA,NA,p.Pro237Lys,-1.807220877,1.75e-52,2.749999999999999e-102,1.807220877 +urn:mavedb:00000041-a-1#2344,NA,NA,p.Pro237Ile,-1.014056998,2.0699999999999996e-53,4.119999999999998e-104,1.014056998 +urn:mavedb:00000041-a-1#2345,NA,NA,p.Pro237Gln,-0.6657415010000001,2.23e-30,5.47e-59,0.6657415010000001 +urn:mavedb:00000041-a-1#2346,NA,NA,p.Pro237Asn,-0.76532559,7.48e-41,1.689999999999999e-79,0.76532559 +urn:mavedb:00000041-a-1#2347,NA,NA,p.Pro237Arg,-1.715751934,2.2599999999999997e-90,1.4299999999999986e-176,1.715751934 +urn:mavedb:00000041-a-1#2348,NA,NA,p.Pro219Tyr,-0.727118203,5.9e-42,1.15e-81,0.727118203 +urn:mavedb:00000041-a-1#2349,NA,NA,p.Pro219Ile,-3.131433646,4.03e-26,1.2099999999999996e-50,3.131433646 +urn:mavedb:00000041-a-1#2350,NA,NA,p.Pro219Cys,-0.765759339,0.853506515,1.11e-16,0.765759339 +urn:mavedb:00000041-a-1#2351,NA,NA,p.Pro218Cys,-0.97093807,9.799999999999999e-64,2.359999999999999e-124,0.97093807 +urn:mavedb:00000041-a-1#2352,NA,NA,p.Pro165Thr,-0.68501838,1.9899999999999992e-73,2.339999999999999e-143,0.68501838 +urn:mavedb:00000041-a-1#2353,NA,NA,p.Pro165Met,-0.6898453059999999,4.21e-38,4.069999999999998e-74,0.6898453059999999 +urn:mavedb:00000041-a-1#2354,NA,NA,p.Pro165Ile,-0.813977053,5.79e-12,4.1899999999999995e-23,0.813977053 +urn:mavedb:00000041-a-1#2355,NA,NA,p.Pro165Cys,-0.727694436,8.96e-06,2.47e-11,0.727694436 +urn:mavedb:00000041-a-1#2356,NA,NA,p.Pro38Trp,-0.638748349,6.590000000000001e-07,2.01e-13,0.638748349 +urn:mavedb:00000041-a-1#2357,NA,NA,p.Pro38Ser,-1.0530685359999998,1.1299999999999994e-66,4.1199999999999974e-130,1.0530685359999998 +urn:mavedb:00000041-a-1#2358,NA,NA,p.Pro38His,-0.634139557,9.24e-31,9.839999999999998e-60,0.634139557 +urn:mavedb:00000041-a-1#2359,NA,NA,p.Pro38Glu,-0.7267502929999999,3.5899999999999997e-28,1.13e-54,0.7267502929999999 +urn:mavedb:00000041-a-1#2360,NA,NA,p.Pro38Gln,-0.6311836510000001,5.61e-56,3.7399999999999994e-109,0.6311836510000001 +urn:mavedb:00000041-a-1#2361,NA,NA,p.Pro38Asp,-0.913469189,3.48e-22,5.8899999999999985e-43,0.913469189 +urn:mavedb:00000041-a-1#2362,NA,NA,p.Pro38Asn,-2.364868657,6.699999999999999e-73,2.6299999999999988e-142,2.364868657 +urn:mavedb:00000041-a-1#2363,NA,NA,p.Pro33Tyr,-2.129842477,1.4499999999999993e-43,8.489999999999996e-85,2.129842477 +urn:mavedb:00000041-a-1#2364,NA,NA,p.Pro33Trp,-0.856451414,8.02e-23,3.34e-44,0.856451414 +urn:mavedb:00000041-a-1#2365,NA,NA,p.Pro33Phe,-1.021492261,2.48e-41,1.9599999999999994e-80,1.021492261 +urn:mavedb:00000041-a-1#2366,NA,NA,p.Pro33Asp,-1.408055584,6e-49,2.339999999999999e-95,1.408055584 +urn:mavedb:00000041-a-1#2367,NA,NA,p.Phe243Val,-1.99843609,3.0199999999999984e-70,4.149999999999998e-137,1.99843609 +urn:mavedb:00000041-a-1#2368,NA,NA,p.Phe243Trp,-3.794427319,3.32e-31,1.419999999999999e-60,3.794427319 +urn:mavedb:00000041-a-1#2369,NA,NA,p.Phe243Thr,-0.85161358,0.004585366,6.12e-07,0.85161358 +urn:mavedb:00000041-a-1#2370,NA,NA,p.Phe243Pro,-2.61284665,4.849999999999999e-60,4.32e-117,2.61284665 +urn:mavedb:00000041-a-1#2371,NA,NA,p.Phe243Met,-1.2934372159999998,4.25e-15,3.83e-29,1.2934372159999998 +urn:mavedb:00000041-a-1#2372,NA,NA,p.Phe243Ile,-2.059510156,5.1299999999999994e-39,6.899999999999997e-76,2.059510156 +urn:mavedb:00000041-a-1#2373,NA,NA,p.Phe243Ala,-1.317114969,9.04e-15,1.64e-28,1.317114969 +urn:mavedb:00000041-a-1#2374,NA,NA,p.Phe83Val,-0.740912675,0.130298517,0.000571261,0.740912675 +urn:mavedb:00000041-a-1#2375,NA,NA,p.Met108Val,-0.964295924,1.81e-31,4.06e-61,0.964295924 +urn:mavedb:00000041-a-1#2376,NA,NA,p.Met108Ser,-0.7686453059999999,4.36e-17,4.82e-33,0.7686453059999999 +urn:mavedb:00000041-a-1#2377,NA,NA,p.Met108Gly,-0.7010609520000001,4.589999999999998e-80,2.209999999999999e-156,0.7010609520000001 +urn:mavedb:00000041-a-1#2378,NA,NA,p.Met108Ala,-1.198458913,9.169999999999998e-60,1.4599999999999995e-116,1.198458913 +urn:mavedb:00000041-a-1#2379,NA,NA,p.Met75Ala,-1.273592604,0.000166892,4.35e-09,1.273592604 +urn:mavedb:00000041-a-1#2380,NA,NA,p.Met17Tyr,-0.654434401,1.96e-18,1.2099999999999998e-35,0.654434401 +urn:mavedb:00000041-a-1#2381,NA,NA,p.Met17Phe,-0.820186867,1.03e-17,2.9999999999999996e-34,0.820186867 +urn:mavedb:00000041-a-1#2382,NA,NA,p.Met17Gly,-2.588876848,1.65e-43,1.11e-84,2.588876848 +urn:mavedb:00000041-a-1#2383,NA,NA,p.Met17Asp,-0.70748546,1.17e-08,9.000000000000001e-17,0.70748546 +urn:mavedb:00000041-a-1#2384,NA,NA,p.Met17Arg,-0.8791878190000001,4.449999999999998e-100,1.299999999999999e-195,0.8791878190000001 +urn:mavedb:00000041-a-1#2385,NA,NA,p.Lys235Cys,-1.287107674,2.5299999999999997e-38,1.4999999999999994e-74,1.287107674 +urn:mavedb:00000041-a-1#2386,NA,NA,p.Lys176Thr,-0.705069895,4.63e-09,1.59e-17,0.705069895 +urn:mavedb:00000041-a-1#2387,NA,NA,p.Lys176Gly,-1.045066235,1.87e-27,2.9299999999999996e-53,1.045066235 +urn:mavedb:00000041-a-1#2388,NA,NA,p.Lys176Asn,-0.7254686920000001,2.2499999999999995e-47,2.73e-92,0.7254686920000001 +urn:mavedb:00000041-a-1#2389,NA,NA,p.Lys176Ala,-0.633866623,1.5699999999999996e-42,8.63e-83,0.633866623 +urn:mavedb:00000041-a-1#2390,NA,NA,p.Lys157Val,-0.684268808,5.92e-26,2.4599999999999997e-50,0.684268808 +urn:mavedb:00000041-a-1#2391,NA,NA,p.Lys157Pro,-2.028068738,3.74e-22,6.9599999999999995e-43,2.028068738 +urn:mavedb:00000041-a-1#2392,NA,NA,p.Lys157Leu,-0.914105732,6.709999999999997e-102,3.4799999999999968e-199,0.914105732 +urn:mavedb:00000041-a-1#2393,NA,NA,p.Lys157Ile,-1.180602073,4.15e-32,2.2599999999999996e-62,1.180602073 +urn:mavedb:00000041-a-1#2394,NA,NA,p.Lys135Thr,-0.968667645,7.78e-21,2.53e-40,0.968667645 +urn:mavedb:00000041-a-1#2395,NA,NA,p.Lys135His,-0.7746924759999999,0.516260786,1.19e-09,0.7746924759999999 +urn:mavedb:00000041-a-1#2396,NA,NA,p.Lys135Asn,-1.6802765080000002,1.28e-21,7.61e-42,1.6802765080000002 +urn:mavedb:00000041-a-1#2397,NA,NA,p.Lys135Arg,-0.78707805,0.983301771,0.0,0.78707805 +urn:mavedb:00000041-a-1#2398,NA,NA,p.Lys90Phe,-0.80850853,0.610158451,1.67e-16,0.80850853 +urn:mavedb:00000041-a-1#2399,NA,NA,p.Lys85Arg,-0.717564482,1.56e-13,3.88e-26,0.717564482 +urn:mavedb:00000041-a-1#2400,NA,NA,p.Lys77Pro,-1.303727281,3.08e-23,5.17e-45,1.303727281 +urn:mavedb:00000041-a-1#2401,NA,NA,p.Lys50His,-0.8067718229999999,0.000686122,5.11e-08,0.8067718229999999 +urn:mavedb:00000041-a-1#2402,NA,NA,p.Lys50Glu,-0.981174928,1.57e-43,9.349999999999997e-85,0.981174928 +urn:mavedb:00000041-a-1#2403,NA,NA,p.Lys32Ile,-2.069902304,1.44e-18,6.96e-36,2.069902304 +urn:mavedb:00000041-a-1#2404,NA,NA,p.Lys6Val,-1.852747169,5.37e-46,1.4399999999999996e-89,1.852747169 +urn:mavedb:00000041-a-1#2405,NA,NA,p.Lys6Tyr,-1.882870745,3.059999999999999e-38,2.319999999999999e-74,1.882870745 +urn:mavedb:00000041-a-1#2406,NA,NA,p.Lys6Met,-0.8246521059999999,1.6699999999999998e-19,9.87e-38,0.8246521059999999 +urn:mavedb:00000041-a-1#2407,NA,NA,p.Lys6Ile,-1.303238476,9.79e-20,3.5299999999999997e-38,1.303238476 +urn:mavedb:00000041-a-1#2408,NA,NA,p.Lys6His,-1.443688476,5.67e-05,8.04e-10,1.443688476 +urn:mavedb:00000041-a-1#2409,NA,NA,p.Lys6Gly,-1.859552471,3.08e-23,5.36e-45,1.859552471 +urn:mavedb:00000041-a-1#2410,NA,NA,p.Lys6Ala,-2.787682681,1.587213035,9.66e-07,2.787682681 +urn:mavedb:00000041-a-1#2411,NA,NA,p.Leu225Phe,-0.632199701,3.9699999999999997e-73,8.719999999999996e-143,0.632199701 +urn:mavedb:00000041-a-1#2412,NA,NA,p.Leu185Trp,-0.7309982770000001,3.97e-23,8.02e-45,0.7309982770000001 +urn:mavedb:00000041-a-1#2413,NA,NA,p.Leu169Trp,-0.868602195,0.242986524,0.001420446,0.868602195 +urn:mavedb:00000041-a-1#2414,NA,NA,p.Leu144Pro,-0.977837345,0.000118779,2.75e-09,0.977837345 +urn:mavedb:00000041-a-1#2415,NA,NA,p.Leu144Lys,-2.2553016830000003,1.5100000000000001e-43,9.299999999999997e-85,2.2553016830000003 +urn:mavedb:00000041-a-1#2416,NA,NA,p.Leu144Gln,-1.151696308,1.1200000000000002e-16,3.31e-32,1.151696308 +urn:mavedb:00000041-a-1#2417,NA,NA,p.Leu144Arg,-1.339833657,6.609999999999999e-13,6.859999999999998e-25,1.339833657 +urn:mavedb:00000041-a-1#2418,NA,NA,p.Leu92Met,-0.831813038,6.26e-06,1.09e-11,0.831813038 +urn:mavedb:00000041-a-1#2419,NA,NA,p.Leu81Val,-0.843322922,7.82e-49,3.829999999999998e-95,0.843322922 +urn:mavedb:00000041-a-1#2420,NA,NA,p.Leu81Tyr,-1.532230845,3.24e-21,4.639999999999998e-41,1.532230845 +urn:mavedb:00000041-a-1#2421,NA,NA,p.Leu81Thr,-0.777631133,5.769999999999999e-28,2.879999999999999e-54,0.777631133 +urn:mavedb:00000041-a-1#2422,NA,NA,p.Leu81Ser,-1.169366931,7.729999999999998e-23,3.12e-44,1.169366931 +urn:mavedb:00000041-a-1#2423,NA,NA,p.Leu81Phe,-0.78647398,4.529999999999999e-35,3.6999999999999975e-68,0.78647398 +urn:mavedb:00000041-a-1#2424,NA,NA,p.Leu81Asp,-1.30067522,2.67e-35,1.3e-68,1.30067522 +urn:mavedb:00000041-a-1#2425,NA,NA,p.Leu81Arg,-1.006749238,6.319999999999996e-81,4.609999999999996e-158,1.006749238 +urn:mavedb:00000041-a-1#2426,NA,NA,p.Leu81Ala,-1.718607224,6.47e-25,2.74e-48,1.718607224 +urn:mavedb:00000041-a-1#2427,NA,NA,p.Leu80Ile,-0.706530443,2.7300000000000005e-13,1.15e-25,0.706530443 +urn:mavedb:00000041-a-1#2428,NA,NA,p.Leu80Ala,-0.8661121890000001,6.8499999999999985e-12,6.099999999999998e-23,0.8661121890000001 +urn:mavedb:00000041-a-1#2429,NA,NA,p.Leu56Val,-0.741994803,1.0300000000000002e-09,9.46e-19,0.741994803 +urn:mavedb:00000041-a-1#2430,NA,NA,p.Leu56Thr,-1.20493392,2.67e-25,4.87e-49,1.20493392 +urn:mavedb:00000041-a-1#2431,NA,NA,p.Leu56Ile,-0.991919167,7.47e-39,1.3899999999999992e-75,0.991919167 +urn:mavedb:00000041-a-1#2432,NA,NA,p.Leu56Cys,-0.882803638,9.39e-14,1.4500000000000002e-26,0.882803638 +urn:mavedb:00000041-a-1#2433,NA,NA,p.Leu56Ala,-0.7344285420000001,1.1599999999999999e-34,2.249999999999999e-67,0.7344285420000001 +urn:mavedb:00000041-a-1#2434,NA,NA,p.Leu31Pro,-1.114191134,1.74e-16,7.74e-32,1.114191134 +urn:mavedb:00000041-a-1#2435,NA,NA,p.Leu31Lys,-0.996899435,0.808763715,1.32e-11,0.996899435 +urn:mavedb:00000041-a-1#2436,NA,NA,p.Leu31Asn,-0.700457443,0.108653607,0.000653494,0.700457443 +urn:mavedb:00000041-a-1#2437,NA,NA,p.Leu31Arg,-2.973358885,1.08e-16,3.22e-32,2.973358885 +urn:mavedb:00000041-a-1#2438,NA,NA,p.Leu7Thr,-2.7125381460000004,2.64e-07,3.89e-14,2.7125381460000004 +urn:mavedb:00000041-a-1#2439,NA,NA,p.Leu7Phe,-1.7558495159999998,3.87e-08,9.96e-16,1.7558495159999998 +urn:mavedb:00000041-a-1#2440,NA,NA,p.Leu7Gly,-1.797458359,1.59e-25,1.8e-49,1.797458359 +urn:mavedb:00000041-a-1#2441,NA,NA,p.Leu1Val,-1.452654149,5.36e-28,2.5399999999999997e-54,1.452654149 +urn:mavedb:00000041-a-1#2442,NA,NA,p.Ile175Val,-1.348264004,5.1100000000000006e-39,6.829999999999998e-76,1.348264004 +urn:mavedb:00000041-a-1#2443,NA,NA,p.Ile175Ala,-1.664838485,3.379999999999998e-97,5.929999999999995e-190,1.664838485 +urn:mavedb:00000041-a-1#2444,NA,NA,p.Ile160Val,-1.495256519,3.0400000000000004e-20,3.56e-39,1.495256519 +urn:mavedb:00000041-a-1#2445,NA,NA,p.Gly199Tyr,-0.8306109070000001,0.377031389,0.0,0.8306109070000001 +urn:mavedb:00000041-a-1#2446,NA,NA,p.Gly199Cys,-1.0894471490000002,1.441020428,0.0,1.0894471490000002 +urn:mavedb:00000041-a-1#2447,NA,NA,p.Gly171Tyr,-0.8232486259999999,3.26e-18,3.2e-35,0.8232486259999999 +urn:mavedb:00000041-a-1#2448,NA,NA,p.Gly171Leu,-1.021361803,7.91e-25,3.98e-48,1.021361803 +urn:mavedb:00000041-a-1#2449,NA,NA,p.Gly129Asp,-0.734082703,0.389572211,1.51e-09,0.734082703 +urn:mavedb:00000041-a-1#2450,NA,NA,p.Gly129Asn,-1.538180472,0.000178685,5.28e-09,1.538180472 +urn:mavedb:00000041-a-1#2451,NA,NA,p.Gly22Tyr,-0.7762834940000001,0.102181166,0.00061107,0.7762834940000001 +urn:mavedb:00000041-a-1#2452,NA,NA,p.Gly22Trp,-0.850197249,1.88e-17,9.88e-34,0.850197249 +urn:mavedb:00000041-a-1#2453,NA,NA,p.Gly22Pro,-1.44502794,6.26e-15,8.09e-29,1.44502794 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+urn:mavedb:00000041-a-1#2572,NA,NA,p.Asn21Pro,-0.978433339,1.42e-46,1.0399999999999996e-90,0.978433339 +urn:mavedb:00000041-a-1#2573,NA,NA,p.Asn21Phe,-0.934325622,1.85e-12,4.730000000000001e-24,0.934325622 +urn:mavedb:00000041-a-1#2574,NA,NA,p.Asn21Ile,-0.7039479940000001,6.47e-43,1.5199999999999992e-83,0.7039479940000001 +urn:mavedb:00000041-a-1#2575,NA,NA,p.Asn21Glu,-0.880033115,1.03e-59,1.79e-116,0.880033115 +urn:mavedb:00000041-a-1#2576,NA,NA,p.Asn21Asp,-1.536942096,3.24e-47,5.859999999999998e-92,1.536942096 +urn:mavedb:00000041-a-1#2577,NA,NA,p.Arg234Asp,-0.650183085,7.009999999999999e-27,3.779999999999998e-52,0.650183085 +urn:mavedb:00000041-a-1#2578,NA,NA,p.Arg203Val,-0.768704321,2.7499999999999997e-81,9.009999999999994e-159,0.768704321 +urn:mavedb:00000041-a-1#2579,NA,NA,p.Arg203Tyr,-0.67180853,4.929999999999998e-89,5.929999999999996e-174,0.67180853 +urn:mavedb:00000041-a-1#2580,NA,NA,p.Arg203Phe,-1.477531791,1.6e-11,3.38e-22,1.477531791 +urn:mavedb:00000041-a-1#2581,NA,NA,p.Arg203Leu,-1.042844117,1.6699999999999992e-91,8.429999999999993e-179,1.042844117 +urn:mavedb:00000041-a-1#2582,NA,NA,p.Arg153Ser,-1.013422301,2.3399999999999995e-56,6.899999999999997e-110,1.013422301 +urn:mavedb:00000041-a-1#2583,NA,NA,p.Arg122Ter,-0.689749455,6.43e-15,8.569999999999998e-29,0.689749455 +urn:mavedb:00000041-a-1#2584,NA,NA,p.Arg113Tyr,-0.7097872190000001,1.7899999999999998e-05,9.75e-11,0.7097872190000001 +urn:mavedb:00000041-a-1#2585,NA,NA,p.Arg113His,-0.674387092,1.35e-06,7.45e-13,0.674387092 +urn:mavedb:00000041-a-1#2586,NA,NA,p.Arg113Asp,-0.736017479,0.319691636,1.39e-17,0.736017479 +urn:mavedb:00000041-a-1#2587,NA,NA,p.Arg52Ser,-1.085460573,1.9e-28,3.32e-55,1.085460573 +urn:mavedb:00000041-a-1#2588,NA,NA,p.Arg52Gly,-0.6853156090000001,2.21e-77,4.049999999999998e-151,0.6853156090000001 +urn:mavedb:00000041-a-1#2589,NA,NA,p.Arg2Trp,-0.688817445,2.76e-60,1.3399999999999992e-117,0.688817445 +urn:mavedb:00000041-a-1#2590,NA,NA,p.Ala168Gly,-1.12485763,2.84e-14,1.43e-27,1.12485763 +urn:mavedb:00000041-a-1#2591,NA,NA,p.Ala164Pro,-2.064011357,5.19e-37,5.849999999999996e-72,2.064011357 +urn:mavedb:00000041-a-1#2592,NA,NA,p.Ala164Cys,-0.7737496209999999,0.366532506,0.0,0.7737496209999999 +urn:mavedb:00000041-a-1#2593,NA,NA,p.Ala164Asp,-1.069768469,6.2199999999999995e-16,8.54e-31,1.069768469 +urn:mavedb:00000041-a-1#2594,NA,NA,p.Ala156Ser,-2.005377606,2.44e-14,1.17e-27,2.005377606 +urn:mavedb:00000041-a-1#2595,NA,NA,p.Ala137Gly,-0.755575784,0.31446720100000003,6.94e-17,0.755575784 +urn:mavedb:00000041-a-1#2596,NA,NA,p.Ala124Asp,-1.30838278,0.701836583,0.009201606,1.30838278 +urn:mavedb:00000041-a-1#2597,NA,NA,p.Ala109Tyr,-1.368151914,5.52e-20,1.1499999999999999e-38,1.368151914 +urn:mavedb:00000041-a-1#2598,NA,NA,p.Ala109Thr,-1.140131661,1.1e-33,1.86e-65,1.140131661 +urn:mavedb:00000041-a-1#2599,NA,NA,p.Ala109Met,-1.717143709,1.99e-43,1.57e-84,1.717143709 +urn:mavedb:00000041-a-1#2600,NA,NA,p.Ala109Leu,-1.577266131,2.75e-29,7.829999999999997e-57,1.577266131 +urn:mavedb:00000041-a-1#2601,NA,NA,p.Ala109Gly,-0.815634482,3.2799999999999998e-22,5.13e-43,0.815634482 +urn:mavedb:00000041-a-1#2602,NA,NA,p.Ala109Asp,-1.909679562,6.23e-13,6.15e-25,1.909679562 +urn:mavedb:00000041-a-1#2603,NA,NA,p.Ala109Asn,-1.027954264,9.67e-10,8.39e-19,1.027954264 +urn:mavedb:00000041-a-1#2604,NA,NA,p.Ala109Arg,-1.278375372,1.4799999999999999e-40,6.49e-79,1.278375372 +urn:mavedb:00000041-a-1#2605,NA,NA,p.Ala105Cys,-0.934354127,4.4299999999999995e-26,1.43e-50,0.934354127 +urn:mavedb:00000041-a-1#2606,NA,NA,p.Ala61Tyr,-0.978025795,6.769999999999999e-24,2.69e-46,0.978025795 +urn:mavedb:00000041-a-1#2607,NA,NA,p.Ala61Trp,-2.599931831,2.09e-18,1.4599999999999995e-35,2.599931831 +urn:mavedb:00000041-a-1#2608,NA,NA,p.Ala61Phe,-0.6846910159999999,0.006049341,1.35e-06,0.6846910159999999 +urn:mavedb:00000041-a-1#2609,NA,NA,p.Ala61His,-0.7471905870000001,7.689999999999999e-30,6.329999999999998e-58,0.7471905870000001 +urn:mavedb:00000041-a-1#2610,NA,NA,p.Ala61Arg,-1.242812941,4.05e-46,8.209999999999997e-90,1.242812941 +urn:mavedb:00000041-a-1#2611,NA,NA,p.Val209Met,0.436288545,0.191174581,0.0,-0.436288545 +urn:mavedb:00000041-a-1#2612,NA,NA,p.Val209Leu,0.405944551,6.1e-14,6.21e-27,-0.405944551 +urn:mavedb:00000041-a-1#2613,NA,NA,p.Val209Ala,0.090462461,0.133811341,0.0,-0.090462461 +urn:mavedb:00000041-a-1#2614,NA,NA,p.Val201Trp,0.237821123,3.01e-12,1.1699999999999997e-23,-0.237821123 +urn:mavedb:00000041-a-1#2615,NA,NA,p.Val201Phe,0.191132165,4.57e-27,1.58e-52,-0.191132165 +urn:mavedb:00000041-a-1#2616,NA,NA,p.Val201Met,0.141811102,2.02e-08,2.36e-16,-0.141811102 +urn:mavedb:00000041-a-1#2617,NA,NA,p.Val201Leu,0.379025512,9.93e-23,4.62e-44,-0.379025512 +urn:mavedb:00000041-a-1#2620,NA,NA,p.Val201Cys,-0.462666444,2.13e-84,7.079999999999995e-165,0.462666444 +urn:mavedb:00000041-a-1#2621,NA,NA,p.Val201Arg,0.339924406,7.68e-09,3.92e-17,-0.339924406 +urn:mavedb:00000041-a-1#2622,NA,NA,p.Val201Ala,-0.525165966,0.283343052,8.329999999999998e-17,0.525165966 +urn:mavedb:00000041-a-1#2623,NA,NA,p.Val195Tyr,-0.297698629,2.87e-51,6.079999999999998e-100,0.297698629 +urn:mavedb:00000041-a-1#2624,NA,NA,p.Val195Trp,-0.150785096,1.3399999999999997e-52,1.5399999999999993e-102,0.150785096 +urn:mavedb:00000041-a-1#2625,NA,NA,p.Val195Pro,-0.482273481,1.08e-10,1.1599999999999997e-20,0.482273481 +urn:mavedb:00000041-a-1#2626,NA,NA,p.Val195Phe,0.012438285,9.08e-15,1.54e-28,-0.012438285 +urn:mavedb:00000041-a-1#2627,NA,NA,p.Val195Met,-0.49610467,5.05e-10,2.43e-19,0.49610467 +urn:mavedb:00000041-a-1#2628,NA,NA,p.Val195Leu,0.004598571,7.01e-30,5.14e-58,-0.004598571 +urn:mavedb:00000041-a-1#2629,NA,NA,p.Val195Ile,-0.299680172,2.57e-10,6.17e-20,0.299680172 +urn:mavedb:00000041-a-1#2630,NA,NA,p.Val195Gly,-0.625884873,1.4599999999999995e-23,1.1199999999999998e-45,0.625884873 +urn:mavedb:00000041-a-1#2631,NA,NA,p.Val195Glu,-0.112449534,0.13192148,6.94e-18,0.112449534 +urn:mavedb:00000041-a-1#2632,NA,NA,p.Val195Cys,-0.50972386,1.15e-18,3.97e-36,0.50972386 +urn:mavedb:00000041-a-1#2633,NA,NA,p.Leu84Ala,0.023945485,0.404904837,0.0,-0.023945485 +urn:mavedb:00000041-a-1#2634,NA,NA,p.Leu81Met,-0.32753684,4.81e-27,1.8399999999999997e-52,0.32753684 +urn:mavedb:00000041-a-1#2635,NA,NA,p.Leu81Ile,-0.35830922299999995,0.152017065,4.07e-10,0.35830922299999995 +urn:mavedb:00000041-a-1#2636,NA,NA,p.Leu81Gly,-0.082063163,5.41e-20,1.02e-38,0.082063163 +urn:mavedb:00000041-a-1#2637,NA,NA,p.Leu81Gln,-0.11021957,5.21e-25,1.72e-48,0.11021957 +urn:mavedb:00000041-a-1#2638,NA,NA,p.Leu81Asn,-0.44401595,1.07e-05,3.29e-11,0.44401595 +urn:mavedb:00000041-a-1#2639,NA,NA,p.Leu80Val,-0.432260827,6.5e-25,2.58e-48,0.432260827 +urn:mavedb:00000041-a-1#2640,NA,NA,p.Leu80Trp,0.449793923,7.2e-11,5.600000000000001e-21,-0.449793923 +urn:mavedb:00000041-a-1#2641,NA,NA,p.Leu80Thr,-0.04476384,0.150101071,0.0,0.04476384 +urn:mavedb:00000041-a-1#2642,NA,NA,p.Leu80Ser,-0.1625491,7.900000000000001e-05,9.32e-10,0.1625491 +urn:mavedb:00000041-a-1#2643,NA,NA,p.Leu80Phe,0.06692562,1.84e-34,5.4199999999999996e-67,-0.06692562 +urn:mavedb:00000041-a-1#2644,NA,NA,p.Leu80Met,0.05540118,0.216272744,3e-05,-0.05540118 +urn:mavedb:00000041-a-1#2645,NA,NA,p.Leu80Gly,-0.5913262,5.34e-50,1.9299999999999997e-97,0.5913262 +urn:mavedb:00000041-a-1#2646,NA,NA,p.Leu80Cys,-0.26496298,2.3899999999999998e-15,1.1900000000000001e-29,0.26496298 +urn:mavedb:00000041-a-1#2647,NA,NA,p.Leu56Ser,-0.296207067,4.1799999999999996e-19,5.6e-37,0.296207067 +urn:mavedb:00000041-a-1#2648,NA,NA,p.Leu56Met,0.040892488,1.65e-29,2.65e-57,-0.040892488 +urn:mavedb:00000041-a-1#2649,NA,NA,p.Leu56Asn,0.310717935,0.066997389,0.000195544,-0.310717935 +urn:mavedb:00000041-a-1#2650,NA,NA,p.Leu42Tyr,-0.34279090100000004,0.556078058,0.0,0.34279090100000004 +urn:mavedb:00000041-a-1#2657,NA,NA,p.Leu31Asp,0.099031288,1.0156895540000002,2.22e-16,-0.099031288 +urn:mavedb:00000041-a-1#2658,NA,NA,p.Leu31Ala,-0.279215063,0.006047109,1.69e-06,0.279215063 +urn:mavedb:00000041-a-1#2659,NA,NA,p.Glu220Ile,0.34258225299999995,6.08e-32,4.6899999999999995e-62,-0.34258225299999995 +urn:mavedb:00000041-a-1#2660,NA,NA,p.Glu220Gly,0.052068172,1.1999999999999999e-51,1.1399999999999992e-100,-0.052068172 +urn:mavedb:00000041-a-1#2661,NA,NA,p.Glu220Cys,-0.006873133000000001,0.58756544,0.0,0.006873133000000001 +urn:mavedb:00000041-a-1#2662,NA,NA,p.Glu220Asp,0.142414184,0.004438925,3.61e-07,-0.142414184 +urn:mavedb:00000041-a-1#2663,NA,NA,p.Glu220Asn,0.174868745,0.134827298,2.8e-15,-0.174868745 +urn:mavedb:00000041-a-1#2664,NA,NA,p.Glu220Arg,-0.094037671,1.94e-26,2.73e-51,0.094037671 +urn:mavedb:00000041-a-1#2665,NA,NA,p.Glu220Ala,-0.166628992,0.476245818,3.72e-12,0.166628992 +urn:mavedb:00000041-a-1#2666,NA,NA,p.Glu210Val,0.374293487,1.04e-11,1.24e-22,-0.374293487 +urn:mavedb:00000041-a-1#2667,NA,NA,p.Glu210Tyr,-0.273792155,3.9899999999999994e-47,8.32e-92,0.273792155 +urn:mavedb:00000041-a-1#2668,NA,NA,p.Glu210Thr,0.191517402,7.440000000000002e-09,3.62e-17,-0.191517402 +urn:mavedb:00000041-a-1#2669,NA,NA,p.Glu210Ser,-0.160154362,9.71e-12,1.1e-22,0.160154362 +urn:mavedb:00000041-a-1#2670,NA,NA,p.Glu210Pro,-0.573473264,1.16e-09,1.0699999999999999e-18,0.573473264 +urn:mavedb:00000041-a-1#2671,NA,NA,p.Glu210Phe,0.17038798300000002,0.238428759,6.94e-18,-0.17038798300000002 +urn:mavedb:00000041-a-1#2672,NA,NA,p.Glu210Lys,0.22295782600000005,0.6703725070000001,1.11e-16,-0.22295782600000005 +urn:mavedb:00000041-a-1#2673,NA,NA,p.Glu210Ile,0.259613342,1.04e-08,7.18e-17,-0.259613342 +urn:mavedb:00000041-a-1#2674,NA,NA,p.Glu210Gln,0.274611285,1.2699999999999999e-90,4.379999999999998e-177,-0.274611285 +urn:mavedb:00000041-a-1#2675,NA,NA,p.Glu210Cys,0.183732736,0.094741702,0.0,-0.183732736 +urn:mavedb:00000041-a-1#2676,NA,NA,p.Glu210Asp,0.272193189,0.007369512,2.61e-06,-0.272193189 +urn:mavedb:00000041-a-1#2677,NA,NA,p.Glu210Asn,0.207784764,1.43e-51,1.6199999999999993e-100,-0.207784764 +urn:mavedb:00000041-a-1#2678,NA,NA,p.Glu210Arg,0.276833043,1.13e-10,1.25e-20,-0.276833043 +urn:mavedb:00000041-a-1#2679,NA,NA,p.Glu210Ala,-0.479878718,1.47e-09,1.7500000000000003e-18,0.479878718 +urn:mavedb:00000041-a-1#2680,NA,NA,p.Glu204Leu,0.327640557,0.117778096,0.000504007,-0.327640557 +urn:mavedb:00000041-a-1#2681,NA,NA,p.Glu149Tyr,-0.546802923,0.366356765,1.19e-15,0.546802923 +urn:mavedb:00000041-a-1#2682,NA,NA,p.Glu149Met,0.195199311,1.5799999999999988e-147,1.1399999999999987e-288,-0.195199311 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+urn:mavedb:00000041-a-1#2833,NA,NA,p.Gln46His,0.013717997,1.97e-09,2.92e-18,-0.013717997 +urn:mavedb:00000041-a-1#2834,NA,NA,p.Gln46Gly,-0.210380454,1.2e-30,1.5899999999999997e-59,0.210380454 +urn:mavedb:00000041-a-1#2835,NA,NA,p.Gln46Glu,-0.439736011,2.52e-13,9.74e-26,0.439736011 +urn:mavedb:00000041-a-1#2836,NA,NA,p.Gln46Cys,0.243255245,0.17102609,1.44e-14,-0.243255245 +urn:mavedb:00000041-a-1#2837,NA,NA,p.Gln46Ala,-0.514529483,0.000140903,2.23e-09,0.514529483 +urn:mavedb:00000041-a-1#2838,NA,NA,p.Gln43Met,-0.477976117,1.4999999999999995e-20,8.579999999999999e-40,0.477976117 +urn:mavedb:00000041-a-1#2839,NA,NA,p.Gln43His,-0.315869496,0.14397649699999998,5.9e-17,0.315869496 +urn:mavedb:00000041-a-1#2840,NA,NA,p.Gln43Gly,-0.553902971,9.71e-22,4.29e-42,0.553902971 +urn:mavedb:00000041-a-1#2841,NA,NA,p.Gln43Glu,0.164466124,7.12e-08,2.5e-15,-0.164466124 +urn:mavedb:00000041-a-1#2842,NA,NA,p.Gln43Asp,0.414050618,0.210069148,0.0,-0.414050618 +urn:mavedb:00000041-a-1#2843,NA,NA,p.Gln43Asn,-0.42287818,1.1799999999999997e-54,1.46e-106,0.42287818 +urn:mavedb:00000041-a-1#2844,NA,NA,p.Gln43Arg,0.222850281,6.8199999999999995e-40,1.2399999999999999e-77,-0.222850281 +urn:mavedb:00000041-a-1#2845,NA,NA,p.Gln9Ser,0.402195004,2.5199999999999997e-30,6.629999999999998e-59,-0.402195004 +urn:mavedb:00000041-a-1#2846,NA,NA,p.Gln9Phe,0.27513906,4.879999999999999e-63,5.279999999999998e-123,-0.27513906 +urn:mavedb:00000041-a-1#2847,NA,NA,p.Gln9Met,0.200625768,9.249999999999996e-78,7.289999999999995e-152,-0.200625768 +urn:mavedb:00000041-a-1#2849,NA,NA,p.Ile175Tyr,-1.569055735,3.63e-26,1.0099999999999998e-50,1.569055735 +urn:mavedb:00000041-a-1#2850,NA,NA,p.Ile175Thr,-1.998223836,9.399999999999999e-21,3.81e-40,1.998223836 +urn:mavedb:00000041-a-1#2851,NA,NA,p.Ile175Ser,-1.246410216,4.3799999999999985e-64,4.949999999999997e-125,1.246410216 +urn:mavedb:00000041-a-1#2852,NA,NA,p.Ile175Pro,-2.726666976,1.2e-30,1.73e-59,2.726666976 +urn:mavedb:00000041-a-1#2853,NA,NA,p.Ile175Met,-0.886450365,7.92e-29,5.969999999999999e-56,0.886450365 +urn:mavedb:00000041-a-1#2854,NA,NA,p.Ile175Lys,-2.9790184930000003,1.4e-05,7.349999999999999e-11,2.9790184930000003 +urn:mavedb:00000041-a-1#2855,NA,NA,p.Ile175Leu,-1.590548185,1.63e-51,2.179999999999999e-100,1.590548185 +urn:mavedb:00000041-a-1#2856,NA,NA,p.Ile175His,-2.601052951,5.390000000000001e-29,2.96e-56,2.601052951 +urn:mavedb:00000041-a-1#2857,NA,NA,p.Ile175Gly,-1.172021399,2.99e-42,3.1199999999999997e-82,1.172021399 +urn:mavedb:00000041-a-1#2858,NA,NA,p.Ile175Glu,-1.3241748290000002,3.4e-12,1.65e-23,1.3241748290000002 +urn:mavedb:00000041-a-1#2859,NA,NA,p.Ile175Gln,-2.205584912,1.43e-59,3.539999999999997e-116,2.205584912 +urn:mavedb:00000041-a-1#2860,NA,NA,p.Ile175Cys,-2.2153029980000003,6.05e-06,1.31e-11,2.2153029980000003 +urn:mavedb:00000041-a-1#2861,NA,NA,p.Ile175Asp,-0.930570785,1.1499999999999996e-64,3.539999999999997e-126,0.930570785 +urn:mavedb:00000041-a-1#2862,NA,NA,p.Ile175Arg,-2.2636661680000003,2.4899999999999995e-51,5.119999999999998e-100,2.2636661680000003 +urn:mavedb:00000041-a-1#2863,NA,NA,p.Thr23Pro,-0.48157127,2.07e-07,2.21e-14,0.48157127 +urn:mavedb:00000041-a-1#2864,NA,NA,p.Thr23Phe,-0.088143885,1.3699999999999996e-21,8.1e-42,0.088143885 +urn:mavedb:00000041-a-1#2865,NA,NA,p.Thr23Met,-0.569436378,0.31326581800000003,0.0,0.569436378 +urn:mavedb:00000041-a-1#2866,NA,NA,p.Thr23Leu,-0.552838189,0.092044932,0.000528694,0.552838189 +urn:mavedb:00000041-a-1#2867,NA,NA,p.Thr23Ile,-0.323890174,0.134641492,2.5e-07,0.323890174 +urn:mavedb:00000041-a-1#2868,NA,NA,p.Thr23His,-0.502664353,1.19e-07,7.2e-15,0.502664353 +urn:mavedb:00000041-a-1#2869,NA,NA,p.Thr23Gly,-0.292321264,0.0020201570000000003,8.789999999999999e-08,0.292321264 +urn:mavedb:00000041-a-1#2870,NA,NA,p.Thr23Glu,-0.346554068,1.74e-46,1.5099999999999996e-90,0.346554068 +urn:mavedb:00000041-a-1#2871,NA,NA,p.Thr23Gln,-0.235585799,2.09e-09,3.1e-18,0.235585799 +urn:mavedb:00000041-a-1#2872,NA,NA,p.Thr23Cys,0.164246804,3.27e-09,7.67e-18,-0.164246804 +urn:mavedb:00000041-a-1#2873,NA,NA,p.Thr19Arg,-0.329213594,4.3e-13,2.7e-25,0.329213594 +urn:mavedb:00000041-a-1#2874,NA,NA,p.Thr19Ala,-0.214037665,9.919999999999997e-76,7.339999999999995e-148,0.214037665 +urn:mavedb:00000041-a-1#2875,NA,NA,p.Ser181Thr,0.459170136,4.43e-14,3.29e-27,-0.459170136 +urn:mavedb:00000041-a-1#2876,NA,NA,p.Ser106Val,0.157693915,7.48e-36,1.0099999999999994e-69,-0.157693915 +urn:mavedb:00000041-a-1#2877,NA,NA,p.Ser106Trp,-0.018752556,3.67e-05,2.7000000000000005e-10,0.018752556 +urn:mavedb:00000041-a-1#2878,NA,NA,p.Ser106Thr,-0.00662606,4.66e-28,1.81e-54,0.00662606 +urn:mavedb:00000041-a-1#2880,NA,NA,p.Ser106Leu,-0.449811763,2.5399999999999995e-61,1.2399999999999995e-119,0.449811763 +urn:mavedb:00000041-a-1#2881,NA,NA,p.Ser106Gly,-0.03904915,1.7899999999999992e-69,1.2499999999999991e-135,0.03904915 +urn:mavedb:00000041-a-1#2882,NA,NA,p.Ser106Glu,0.08044194,3.0499999999999993e-40,2.43e-78,-0.08044194 +urn:mavedb:00000041-a-1#2883,NA,NA,p.Ser106Gln,0.082250554,1.63e-46,1.2799999999999995e-90,-0.082250554 +urn:mavedb:00000041-a-1#2884,NA,NA,p.Ser106Ala,0.138529611,0.309864105,2.78e-17,-0.138529611 +urn:mavedb:00000041-a-1#2885,NA,NA,p.Ser79Cys,0.13460403599999998,0.266618434,2.78e-17,-0.13460403599999998 +urn:mavedb:00000041-a-1#2886,NA,NA,p.Ser76Val,-0.237327837,6.24e-22,1.67e-42,0.237327837 +urn:mavedb:00000041-a-1#2887,NA,NA,p.Ser76Tyr,-0.2053453,0.438962746,0.0,0.2053453 +urn:mavedb:00000041-a-1#2888,NA,NA,p.Ser76Thr,0.160542767,0.378006532,2.22e-16,-0.160542767 +urn:mavedb:00000041-a-1#2889,NA,NA,p.Ser76Pro,-0.359811402,2.6799999999999996e-58,1.0699999999999993e-113,0.359811402 +urn:mavedb:00000041-a-1#2890,NA,NA,p.Ser76Met,-0.5550601310000001,0.000120978,2.94e-09,0.5550601310000001 +urn:mavedb:00000041-a-1#2891,NA,NA,p.Ser76Ile,-0.414328929,7.320000000000002e-16,1.15e-30,0.414328929 +urn:mavedb:00000041-a-1#2892,NA,NA,p.Ser76His,-0.081480859,0.079963224,4.76e-09,0.081480859 +urn:mavedb:00000041-a-1#2893,NA,NA,p.Ser76Gly,-0.04241427,0.101964908,1.16e-05,0.04241427 +urn:mavedb:00000041-a-1#2894,NA,NA,p.Ser76Cys,-0.301781432,3.83e-11,1.5699999999999999e-21,0.301781432 +urn:mavedb:00000041-a-1#2895,NA,NA,p.Ser76Asp,-0.533897398,3.6100000000000003e-37,2.839999999999999e-72,0.533897398 +urn:mavedb:00000041-a-1#2896,NA,NA,p.Ser76Asn,0.006791038,0.007339414,8.990000000000002e-07,-0.006791038 +urn:mavedb:00000041-a-1#2897,NA,NA,p.Ser64Tyr,0.054731463,1.6399999999999998e-13,4.15e-26,-0.054731463 +urn:mavedb:00000041-a-1#2898,NA,NA,p.Ser64His,-0.370696553,4.6899999999999996e-46,1.0599999999999994e-89,0.370696553 +urn:mavedb:00000041-a-1#2899,NA,NA,p.Ser64Glu,0.020750405,2.0899999999999998e-19,1.44e-37,-0.020750405 +urn:mavedb:00000041-a-1#2900,NA,NA,p.Ser37Pro,0.448128965,1.8199999999999998e-33,4.929999999999998e-65,-0.448128965 +urn:mavedb:00000041-a-1#2901,NA,NA,p.Ser37Gly,-0.03346797,1.5e-05,5.41e-11,0.03346797 +urn:mavedb:00000041-a-1#2902,NA,NA,p.Ser37Ala,0.448881323,1.8499999999999997e-70,1.559999999999999e-137,-0.448881323 +urn:mavedb:00000041-a-1#2903,NA,NA,p.Pro241Lys,0.41656182,0.135481046,1.24e-09,-0.41656182 +urn:mavedb:00000041-a-1#2904,NA,NA,p.Pro241Ile,-0.405065158,0.226932116,0.000521731,0.405065158 +urn:mavedb:00000041-a-1#2905,NA,NA,p.Pro241Gly,0.045261329,0.283647807,1.39e-17,-0.045261329 +urn:mavedb:00000041-a-1#2906,NA,NA,p.Pro241Glu,0.251151134,3.9599999999999995e-37,3.2799999999999986e-72,-0.251151134 +urn:mavedb:00000041-a-1#2907,NA,NA,p.Pro241Gln,0.402890155,4.22e-73,9.979999999999999e-143,-0.402890155 +urn:mavedb:00000041-a-1#2908,NA,NA,p.Pro237Val,-0.404489367,8.06e-10,5.24e-19,0.404489367 +urn:mavedb:00000041-a-1#2909,NA,NA,p.Pro237Thr,-0.319806405,3.6499999999999997e-31,1.52e-60,0.319806405 +urn:mavedb:00000041-a-1#2911,NA,NA,p.Pro237Met,-0.5451733329999999,5.189999999999999e-89,6.449999999999997e-174,0.5451733329999999 +urn:mavedb:00000041-a-1#2912,NA,NA,p.Pro237Leu,-0.292636639,2.3e-10,5.019999999999999e-20,0.292636639 +urn:mavedb:00000041-a-1#2913,NA,NA,p.Pro237Gly,-0.294216931,0.097871966,5.98e-09,0.294216931 +urn:mavedb:00000041-a-1#2914,NA,NA,p.Pro237Glu,-0.139337305,1.2e-21,6.08e-42,0.139337305 +urn:mavedb:00000041-a-1#2915,NA,NA,p.Pro237Cys,-0.200714335,0.157255338,1.02e-13,0.200714335 +urn:mavedb:00000041-a-1#2916,NA,NA,p.Pro237Asp,-0.097620276,0.200048045,0.0,0.097620276 +urn:mavedb:00000041-a-1#2917,NA,NA,p.Pro237Ala,0.064076932,1.8199999999999998e-33,4.45e-65,-0.064076932 +urn:mavedb:00000041-a-1#2918,NA,NA,p.Pro222Tyr,0.288166579,2.27e-16,1.19e-31,-0.288166579 +urn:mavedb:00000041-a-1#2919,NA,NA,p.Pro222Met,0.231417549,5.350000000000001e-29,2.67e-56,-0.231417549 +urn:mavedb:00000041-a-1#2920,NA,NA,p.Pro222Lys,0.3625169720000001,2.4e-29,5.5e-57,-0.3625169720000001 +urn:mavedb:00000041-a-1#2921,NA,NA,p.Pro222Ile,0.394678366,5.619999999999999e-32,3.989999999999997e-62,-0.394678366 +urn:mavedb:00000041-a-1#2922,NA,NA,p.Pro222Cys,0.14546473599999998,1.72e-48,1.7e-94,-0.14546473599999998 +urn:mavedb:00000041-a-1#2923,NA,NA,p.Pro222Arg,0.399615208,1.4899999999999998e-28,1.96e-55,-0.399615208 +urn:mavedb:00000041-a-1#2924,NA,NA,p.Pro222Ala,0.32139075100000003,3.7e-05,2.85e-10,-0.32139075100000003 +urn:mavedb:00000041-a-1#2925,NA,NA,p.Pro219Val,-0.1413502,1.6399999999999998e-33,3.829999999999998e-65,0.1413502 +urn:mavedb:00000041-a-1#2926,NA,NA,p.Pro219Thr,-0.07338688,1.58e-64,6.189999999999998e-126,0.07338688 +urn:mavedb:00000041-a-1#2927,NA,NA,p.Pro219Ser,-0.427115659,3.7599999999999996e-37,2.869999999999999e-72,0.427115659 +urn:mavedb:00000041-a-1#2928,NA,NA,p.Pro219Met,-0.209766277,0.17904256100000002,1.97e-11,0.209766277 +urn:mavedb:00000041-a-1#2929,NA,NA,p.Pro219Lys,0.269656237,0.133270417,6.379999999999999e-11,-0.269656237 +urn:mavedb:00000041-a-1#2930,NA,NA,p.Pro219His,-0.245518055,1.03e-31,1.34e-61,0.245518055 +urn:mavedb:00000041-a-1#2931,NA,NA,p.Pro219Asp,0.146881441,1.53e-10,2.19e-20,-0.146881441 +urn:mavedb:00000041-a-1#2932,NA,NA,p.Pro219Arg,-0.274592707,4.84e-05,3.9100000000000005e-10,0.274592707 +urn:mavedb:00000041-a-1#2933,NA,NA,p.Pro219Ala,-0.205492721,4.5299999999999994e-45,9.039999999999994e-88,0.205492721 +urn:mavedb:00000041-a-1#2934,NA,NA,p.Pro218Val,-0.036031922,0.188503469,6.94e-18,0.036031922 +urn:mavedb:00000041-a-1#2935,NA,NA,p.Pro218Tyr,0.23136334,1.11e-11,1.49e-22,-0.23136334 +urn:mavedb:00000041-a-1#2936,NA,NA,p.Pro218Ser,0.411700864,4.78e-87,4.389999999999998e-170,-0.411700864 +urn:mavedb:00000041-a-1#2937,NA,NA,p.Pro218Leu,0.379032444,3.05e-50,6.319999999999998e-98,-0.379032444 +urn:mavedb:00000041-a-1#2938,NA,NA,p.Pro218Ile,-0.123283436,0.11423193,6.92e-05,0.123283436 +urn:mavedb:00000041-a-1#2939,NA,NA,p.Pro218Glu,0.054349099000000005,0.09356771,0.00025741,-0.054349099000000005 +urn:mavedb:00000041-a-1#2940,NA,NA,p.Pro218Ala,0.405352574,5.14e-57,3.3899999999999994e-111,-0.405352574 +urn:mavedb:00000041-a-1#2941,NA,NA,p.Pro216Val,0.31645659600000003,4.570000000000001e-19,6.69e-37,-0.31645659600000003 +urn:mavedb:00000041-a-1#2942,NA,NA,p.Pro216Tyr,0.403372615,0.21033365,2.0800000000000003e-17,-0.403372615 +urn:mavedb:00000041-a-1#2943,NA,NA,p.Pro216Thr,0.262163449,8.32e-49,4.129999999999998e-95,-0.262163449 +urn:mavedb:00000041-a-1#2944,NA,NA,p.Pro216Ser,0.194546977,5.96e-42,1.1099999999999994e-81,-0.194546977 +urn:mavedb:00000041-a-1#2945,NA,NA,p.Pro216Met,0.25199956100000004,6.370000000000001e-18,1.11e-34,-0.25199956100000004 +urn:mavedb:00000041-a-1#2946,NA,NA,p.Pro216Lys,0.238924249,2.7899999999999993e-65,2.149999999999999e-127,-0.238924249 +urn:mavedb:00000041-a-1#2947,NA,NA,p.Pro216Leu,0.309671183,1.31e-36,3.389999999999999e-71,-0.309671183 +urn:mavedb:00000041-a-1#2948,NA,NA,p.Pro216Ile,0.453175232,0.085960387,1.55e-06,-0.453175232 +urn:mavedb:00000041-a-1#2949,NA,NA,p.Pro216His,0.36471904,7.359999999999998e-35,9.189999999999999e-68,-0.36471904 +urn:mavedb:00000041-a-1#2950,NA,NA,p.Pro216Gly,0.189926389,0.13523134,2.49e-15,-0.189926389 +urn:mavedb:00000041-a-1#2951,NA,NA,p.Pro216Glu,0.246320925,5.72e-11,3.1399999999999997e-21,-0.246320925 +urn:mavedb:00000041-a-1#2952,NA,NA,p.Pro216Gln,0.073903048,0.169902618,0.0,-0.073903048 +urn:mavedb:00000041-a-1#2953,NA,NA,p.Pro216Cys,0.368276461,4.68e-07,8.54e-14,-0.368276461 +urn:mavedb:00000041-a-1#2954,NA,NA,p.Pro216Asp,0.126572527,2.61e-45,3.049999999999998e-88,-0.126572527 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+urn:mavedb:00000041-a-1#2964,NA,NA,p.Pro198Gly,0.364891698,6.7099999999999994e-31,4.909999999999999e-60,-0.364891698 +urn:mavedb:00000041-a-1#2965,NA,NA,p.Pro198Cys,0.17555396,8.599999999999999e-14,1.17e-26,-0.17555396 +urn:mavedb:00000041-a-1#2966,NA,NA,p.Pro198Ala,0.080655832,0.261408725,1.39e-17,-0.080655832 +urn:mavedb:00000041-a-1#2967,NA,NA,p.Pro196Val,-0.13005778099999998,0.019800219,4.21e-16,0.13005778099999998 +urn:mavedb:00000041-a-1#2968,NA,NA,p.Pro165Val,-0.021545204,3.81e-32,1.9499999999999997e-62,0.021545204 +urn:mavedb:00000041-a-1#2969,NA,NA,p.Pro165Tyr,0.082571185,1.1e-38,2.9399999999999985e-75,-0.082571185 +urn:mavedb:00000041-a-1#2970,NA,NA,p.Pro165Ser,-0.117923989,4.06e-06,4.88e-12,0.117923989 +urn:mavedb:00000041-a-1#2972,NA,NA,p.Pro165Leu,0.133275533,6.84e-36,8.249999999999998e-70,-0.133275533 +urn:mavedb:00000041-a-1#2973,NA,NA,p.Pro165His,0.329094477,0.324176275,0.0,-0.329094477 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+urn:mavedb:00000041-a-1#3059,NA,NA,p.Met108Cys,-0.551102697,0.003340529,2.08e-07,0.551102697 +urn:mavedb:00000041-a-1#3060,NA,NA,p.Met100Val,0.117027035,4.98e-16,5.55e-31,-0.117027035 +urn:mavedb:00000041-a-1#3061,NA,NA,p.Met100Thr,0.257106718,7.9e-08,3.2e-15,-0.257106718 +urn:mavedb:00000041-a-1#3062,NA,NA,p.Met100Phe,-7.929999999999999e-05,0.43511406,2.78e-17,7.929999999999999e-05 +urn:mavedb:00000041-a-1#3063,NA,NA,p.Gln9Cys,0.156025821,0.116534604,2.17e-09,-0.156025821 +urn:mavedb:00000041-a-1#3064,NA,NA,p.Gln9Ala,-0.12320552,7.029999999999999e-11,5.14e-21,0.12320552 +urn:mavedb:00000041-a-1#3066,NA,NA,p.Cys232Thr,0.084210152,5.349999999999999e-63,6.279999999999996e-123,-0.084210152 +urn:mavedb:00000041-a-1#3067,NA,NA,p.Cys232Ser,-0.117665888,9.41e-06,2.39e-11,0.117665888 +urn:mavedb:00000041-a-1#3068,NA,NA,p.Cys232Met,0.368407307,2.9999999999999996e-39,2.3499999999999995e-76,-0.368407307 +urn:mavedb:00000041-a-1#3069,NA,NA,p.Cys232Leu,-0.28360493800000003,5.009999999999998e-34,3.8499999999999995e-66,0.28360493800000003 +urn:mavedb:00000041-a-1#3070,NA,NA,p.Cys232Ile,0.387292827,1.82e-27,2.68e-53,-0.387292827 +urn:mavedb:00000041-a-1#3071,NA,NA,p.Cys232Asn,-0.260412529,1.75e-15,6.81e-30,0.260412529 +urn:mavedb:00000041-a-1#3072,NA,NA,p.Cys232Ala,0.339993562,2.88e-16,1.8699999999999998e-31,-0.339993562 +urn:mavedb:00000041-a-1#3073,NA,NA,p.Cys230Val,0.206900803,0.130910496,0.0,-0.206900803 +urn:mavedb:00000041-a-1#3074,NA,NA,p.Cys230Trp,0.002633251,2.24e-05,1.25e-10,-0.002633251 +urn:mavedb:00000041-a-1#3075,NA,NA,p.Cys230Thr,0.415493581,7.59e-09,3.73e-17,-0.415493581 +urn:mavedb:00000041-a-1#3076,NA,NA,p.Cys230Ser,0.045192655,0.158631454,1.2900000000000002e-11,-0.045192655 +urn:mavedb:00000041-a-1#3077,NA,NA,p.Cys230Met,0.224632283,1.08e-42,3.98e-83,-0.224632283 +urn:mavedb:00000041-a-1#3078,NA,NA,p.Cys230Leu,0.110708022,0.5172816060000001,0.0,-0.110708022 +urn:mavedb:00000041-a-1#3079,NA,NA,p.Cys230Gly,0.039738014,4.460000000000001e-56,2.3399999999999993e-109,-0.039738014 +urn:mavedb:00000041-a-1#3080,NA,NA,p.Cys230Gln,-0.087477155,2.43e-31,7.02e-61,0.087477155 +urn:mavedb:00000041-a-1#3081,NA,NA,p.Cys230Arg,-0.5492728920000001,1.46e-05,4.91e-11,0.5492728920000001 +urn:mavedb:00000041-a-1#3082,NA,NA,p.Cys230Ala,0.041209074,0.001208698,8.54e-08,-0.041209074 +urn:mavedb:00000041-a-1#3083,NA,NA,p.Cys221Val,0.298562847,2.56e-14,1.1099999999999998e-27,-0.298562847 +urn:mavedb:00000041-a-1#3084,NA,NA,p.Cys221Thr,0.138444465,1.0699999999999999e-53,1.0999999999999996e-104,-0.138444465 +urn:mavedb:00000041-a-1#3085,NA,NA,p.Cys221Leu,-0.062207584,0.394863188,2.78e-17,0.062207584 +urn:mavedb:00000041-a-1#3086,NA,NA,p.Cys221Ile,0.398354783,9.79e-10,8.159999999999998e-19,-0.398354783 +urn:mavedb:00000041-a-1#3087,NA,NA,p.Cys221Ala,0.292753679,7.32e-35,9.169999999999999e-68,-0.292753679 +urn:mavedb:00000041-a-1#3088,NA,NA,p.Cys217Val,-0.023222538,4.94e-23,1.25e-44,0.023222538 +urn:mavedb:00000041-a-1#3089,NA,NA,p.Cys217Thr,-0.413111674,3.26e-24,6.22e-47,0.413111674 +urn:mavedb:00000041-a-1#3090,NA,NA,p.Cys217Ser,-0.014641025,0.640577278,0.0,0.014641025 +urn:mavedb:00000041-a-1#3091,NA,NA,p.Cys217Pro,-0.320315167,2.29e-06,1.66e-12,0.320315167 +urn:mavedb:00000041-a-1#3092,NA,NA,p.Cys217Met,0.34461490100000003,2.02e-27,3.36e-53,-0.34461490100000003 +urn:mavedb:00000041-a-1#3093,NA,NA,p.Cys217Lys,-0.2984941,0.2243737,2.78e-17,0.2984941 +urn:mavedb:00000041-a-1#3094,NA,NA,p.Cys217Leu,-0.267875754,1.1200000000000002e-20,4.8e-40,0.267875754 +urn:mavedb:00000041-a-1#3095,NA,NA,p.Cys217Gly,0.01233743,4.11e-27,1.3499999999999999e-52,-0.01233743 +urn:mavedb:00000041-a-1#3096,NA,NA,p.Cys217Glu,0.4178441020000001,1.0199999999999996e-55,1.239999999999999e-108,-0.4178441020000001 +urn:mavedb:00000041-a-1#3097,NA,NA,p.Cys217Gln,-0.38281055,0.800366975,0.0,0.38281055 +urn:mavedb:00000041-a-1#3098,NA,NA,p.Cys217Arg,-0.510867659,3.91e-05,3.41e-10,0.510867659 +urn:mavedb:00000041-a-1#3099,NA,NA,p.Cys217Ala,-0.430253314,0.344253124,6.65e-08,0.430253314 +urn:mavedb:00000041-a-1#3100,NA,NA,p.Cys134Val,0.198974266,1.19e-09,1.15e-18,-0.198974266 +urn:mavedb:00000041-a-1#3101,NA,NA,p.Cys134Tyr,0.339278709,5.1e-91,7.229999999999995e-178,-0.339278709 +urn:mavedb:00000041-a-1#3102,NA,NA,p.Cys134Ser,0.299233342,2.03e-11,4.58e-22,-0.299233342 +urn:mavedb:00000041-a-1#3103,NA,NA,p.Cys134Met,0.163726021,0.031949904,7.070000000000001e-05,-0.163726021 +urn:mavedb:00000041-a-1#3104,NA,NA,p.Cys134Ile,0.091779304,2.68e-20,2.72e-39,-0.091779304 +urn:mavedb:00000041-a-1#3105,NA,NA,p.Cys134Ala,-0.253304069,4.45e-34,2.999999999999998e-66,0.253304069 +urn:mavedb:00000041-a-1#3106,NA,NA,p.Cys11Tyr,-0.513025307,0.010535484,6.16e-06,0.513025307 +urn:mavedb:00000041-a-1#3107,NA,NA,p.Cys11Phe,0.380870544,0.0034040570000000003,7.780000000000001e-08,-0.380870544 +urn:mavedb:00000041-a-1#3108,NA,NA,p.Cys11His,-0.558470975,1.22e-17,4.15e-34,0.558470975 +urn:mavedb:00000041-a-1#3109,NA,NA,p.Cys11Ala,-0.295683377,0.168319072,2.51e-05,0.295683377 +urn:mavedb:00000041-a-1#3110,NA,NA,p.Asp227Val,-0.271460339,0.515516658,0.0,0.271460339 +urn:mavedb:00000041-a-1#3111,NA,NA,p.Asp227Leu,-0.467587168,2.5e-07,3.05e-14,0.467587168 +urn:mavedb:00000041-a-1#3112,NA,NA,p.Asp207Val,-0.403235136,9.35e-28,6.99e-54,0.403235136 +urn:mavedb:00000041-a-1#3113,NA,NA,p.Asp207Tyr,0.008023196,0.334391351,0.0,-0.008023196 +urn:mavedb:00000041-a-1#3114,NA,NA,p.Asp147Thr,0.382936677,5.350000000000001e-05,4.95e-10,-0.382936677 +urn:mavedb:00000041-a-1#3115,NA,NA,p.Asp82Thr,0.423171512,4.79e-28,1.94e-54,-0.423171512 +urn:mavedb:00000041-a-1#3116,NA,NA,p.Asp82Ser,0.151349585,1.62e-49,1.6699999999999993e-96,-0.151349585 +urn:mavedb:00000041-a-1#3117,NA,NA,p.Asp82Phe,-0.083143784,0.34859137100000004,0.0,0.083143784 +urn:mavedb:00000041-a-1#3118,NA,NA,p.Asp82Ile,0.34008784700000005,1.19e-49,9.42e-97,-0.34008784700000005 +urn:mavedb:00000041-a-1#3119,NA,NA,p.Asp82His,0.033497712,0.097493733,1.57e-13,-0.033497712 +urn:mavedb:00000041-a-1#3120,NA,NA,p.Asp82Gly,0.161292111,1.55e-13,3.29e-26,-0.161292111 +urn:mavedb:00000041-a-1#3121,NA,NA,p.Asp82Glu,0.015687841,0.002205962,4.45e-08,-0.015687841 +urn:mavedb:00000041-a-1#3122,NA,NA,p.Asp82Gln,0.115775168,9.37e-41,2.4899999999999992e-79,-0.115775168 +urn:mavedb:00000041-a-1#3123,NA,NA,p.Asp82Cys,0.128582187,1.18e-53,1.2999999999999999e-104,-0.128582187 +urn:mavedb:00000041-a-1#3124,NA,NA,p.Asp82Asn,0.41418078,3.28e-27,8.359999999999996e-53,-0.41418078 +urn:mavedb:00000041-a-1#3125,NA,NA,p.Asp82Ala,0.326084523,3.1300000000000005e-29,9.47e-57,-0.326084523 +urn:mavedb:00000041-a-1#3126,NA,NA,p.Asn148Thr,0.14126433800000002,9.44e-15,1.61e-28,-0.14126433800000002 +urn:mavedb:00000041-a-1#3127,NA,NA,p.Asn148Ser,0.253679007,2.52e-72,3.269999999999998e-141,-0.253679007 +urn:mavedb:00000041-a-1#3128,NA,NA,p.Asn148His,0.377443259,0.886227014,0.0,-0.377443259 +urn:mavedb:00000041-a-1#3129,NA,NA,p.Asn148Glu,0.052872772,0.0004980469999999999,1.9e-08,-0.052872772 +urn:mavedb:00000041-a-1#3130,NA,NA,p.Asn148Gln,0.35804199299999995,1.9300000000000007e-21,1.5599999999999998e-41,-0.35804199299999995 +urn:mavedb:00000041-a-1#3131,NA,NA,p.Asn131Ile,-0.069530543,1.386220582,0.0,0.069530543 +urn:mavedb:00000041-a-1#3132,NA,NA,p.Asn115Tyr,-0.29651783800000003,5.609999999999999e-26,2.2e-50,0.29651783800000003 +urn:mavedb:00000041-a-1#3133,NA,NA,p.Asn115Pro,0.065050069,7.87e-30,6.329999999999998e-58,-0.065050069 +urn:mavedb:00000041-a-1#3134,NA,NA,p.Asn115Phe,-0.060904364,3.81e-22,6.82e-43,0.060904364 +urn:mavedb:00000041-a-1#3135,NA,NA,p.Asn115Met,-0.153474939,0.626618687,2.22e-16,0.153474939 +urn:mavedb:00000041-a-1#3136,NA,NA,p.Asn115Leu,-0.082878298,1.06e-06,3.81e-13,0.082878298 +urn:mavedb:00000041-a-1#3137,NA,NA,p.Asn115Gly,-0.090868224,8.849999999999999e-37,1.5499999999999994e-71,0.090868224 +urn:mavedb:00000041-a-1#3138,NA,NA,p.Asn115Gln,-0.057908282,4.9e-54,2.4099999999999997e-105,0.057908282 +urn:mavedb:00000041-a-1#3139,NA,NA,p.Asn115Cys,-0.221287595,0.193511725,7.03e-13,0.221287595 +urn:mavedb:00000041-a-1#3140,NA,NA,p.Asn21Val,-0.396924462,3.5e-43,4.469999999999998e-84,0.396924462 +urn:mavedb:00000041-a-1#3141,NA,NA,p.Asn21Thr,-0.442479805,2.6899999999999985e-85,1.2099999999999995e-166,0.442479805 +urn:mavedb:00000041-a-1#3142,NA,NA,p.Asn21Ser,-0.121421134,0.043889734000000014,2.89e-08,0.121421134 +urn:mavedb:00000041-a-1#3143,NA,NA,p.Asn21Met,-0.184259275,2e-46,1.9099999999999995e-90,0.184259275 +urn:mavedb:00000041-a-1#3144,NA,NA,p.Asn21Leu,-0.237981026,3.63e-14,2.15e-27,0.237981026 +urn:mavedb:00000041-a-1#3145,NA,NA,p.Asn21His,-0.40540492,0.280425689,0.0,0.40540492 +urn:mavedb:00000041-a-1#3146,NA,NA,p.Asn21Gly,-0.21306765,1.7899999999999998e-11,3.5599999999999996e-22,0.21306765 +urn:mavedb:00000041-a-1#3147,NA,NA,p.Asn21Gln,-0.006349465,1.5199999999999998e-23,1.1499999999999998e-45,0.006349465 +urn:mavedb:00000041-a-1#3148,NA,NA,p.Asn21Cys,-0.404824547,1.13e-67,4.349999999999997e-132,0.404824547 +urn:mavedb:00000041-a-1#3149,NA,NA,p.Asn21Arg,0.15570792,0.112693424,3.47e-18,-0.15570792 +urn:mavedb:00000041-a-1#3150,NA,NA,p.Asn21Ala,-0.250344568,2.28e-37,1.0699999999999996e-72,0.250344568 +urn:mavedb:00000041-a-1#3151,NA,NA,p.Arg234Val,0.33992798700000004,0.239811571,3.82e-16,-0.33992798700000004 +urn:mavedb:00000041-a-1#3152,NA,NA,p.Arg234Tyr,-0.114790078,0.073853641,5.01e-06,0.114790078 +urn:mavedb:00000041-a-1#3153,NA,NA,p.Arg234Trp,-0.313876127,1.11e-16,2.8199999999999996e-32,0.313876127 +urn:mavedb:00000041-a-1#3154,NA,NA,p.Arg234Thr,0.052398181,3.32e-25,6.629999999999998e-49,-0.052398181 +urn:mavedb:00000041-a-1#3155,NA,NA,p.Arg234Ser,-0.519087105,2.6399999999999997e-41,2.109999999999999e-80,0.519087105 +urn:mavedb:00000041-a-1#3156,NA,NA,p.Arg234Phe,-0.029032956,9.849999999999996e-65,2.479999999999999e-126,0.029032956 +urn:mavedb:00000041-a-1#3157,NA,NA,p.Arg234Met,0.120448094,5.92e-15,6.750000000000001e-29,-0.120448094 +urn:mavedb:00000041-a-1#3158,NA,NA,p.Arg234Lys,0.058999781,5.179999999999998e-16,6.2e-31,-0.058999781 +urn:mavedb:00000041-a-1#3159,NA,NA,p.Arg234Leu,-0.054973274,0.097001928,2.9e-11,0.054973274 +urn:mavedb:00000041-a-1#3160,NA,NA,p.Arg234Ile,0.369880307,4.31e-21,7.619999999999998e-41,-0.369880307 +urn:mavedb:00000041-a-1#3161,NA,NA,p.Arg234His,-0.5607189779999999,0.16670317,8.43e-09,0.5607189779999999 +urn:mavedb:00000041-a-1#3162,NA,NA,p.Arg234Gly,0.015720248,2.54e-26,4.12e-51,-0.015720248 +urn:mavedb:00000041-a-1#3163,NA,NA,p.Arg234Glu,0.181330916,0.097698084,6.66e-11,-0.181330916 +urn:mavedb:00000041-a-1#3164,NA,NA,p.Arg234Gln,0.20174167,0.117362215,4.8e-08,-0.20174167 +urn:mavedb:00000041-a-1#3165,NA,NA,p.Arg234Cys,-0.18270636,0.152794279,6.64e-08,0.18270636 +urn:mavedb:00000041-a-1#3166,NA,NA,p.Arg234Asn,-0.278070039,1.7099999999999994e-84,4.619999999999996e-165,0.278070039 +urn:mavedb:00000041-a-1#3167,NA,NA,p.Arg234Ala,-0.131237754,0.24431015,2.0800000000000003e-17,0.131237754 +urn:mavedb:00000041-a-1#3168,NA,NA,p.Arg214Val,-0.114231645,9.67e-45,3.8399999999999986e-87,0.114231645 +urn:mavedb:00000041-a-1#3169,NA,NA,p.Arg214Tyr,0.133059336,1.0099999999999998e-57,1.3799999999999993e-112,-0.133059336 +urn:mavedb:00000041-a-1#3170,NA,NA,p.Arg214Thr,-0.296814337,0.26961345,1.39e-17,0.296814337 +urn:mavedb:00000041-a-1#3171,NA,NA,p.Arg214Phe,0.316444137,1.17e-08,8.65e-17,-0.316444137 +urn:mavedb:00000041-a-1#3172,NA,NA,p.Arg214Met,0.185420502,9.9e-17,2.2499999999999997e-32,-0.185420502 +urn:mavedb:00000041-a-1#3173,NA,NA,p.Arg214Lys,-0.070220222,0.22056754,0.0,0.070220222 +urn:mavedb:00000041-a-1#3174,NA,NA,p.Arg214Leu,-0.056046304000000005,3.049999999999999e-24,4.87e-47,0.056046304000000005 +urn:mavedb:00000041-a-1#3175,NA,NA,p.Arg214Ile,-0.255728413,7.389999999999998e-36,1.0099999999999994e-69,0.255728413 +urn:mavedb:00000041-a-1#3176,NA,NA,p.Arg214His,-0.451209178,8.22e-33,9.109999999999997e-64,0.451209178 +urn:mavedb:00000041-a-1#3177,NA,NA,p.Arg214Gln,-0.224769748,8.42e-24,3.68e-46,0.224769748 +urn:mavedb:00000041-a-1#3178,NA,NA,p.Arg214Cys,0.197712285,1.64e-16,5.969999999999998e-32,-0.197712285 +urn:mavedb:00000041-a-1#3179,NA,NA,p.Arg214Asn,0.1006695,1.6800000000000002e-19,8.71e-38,-0.1006695 +urn:mavedb:00000041-a-1#3180,NA,NA,p.Arg211Val,0.043286142,0.112689269,0.0,-0.043286142 +urn:mavedb:00000041-a-1#3181,NA,NA,p.Arg211Tyr,-0.59908354,2.41e-48,3.3899999999999996e-94,0.59908354 +urn:mavedb:00000041-a-1#3182,NA,NA,p.Arg211Thr,0.34342048700000005,8.25e-32,8.249999999999995e-62,-0.34342048700000005 +urn:mavedb:00000041-a-1#3183,NA,NA,p.Arg211Ser,0.248263985,4.9299999999999974e-82,3.009999999999998e-160,-0.248263985 +urn:mavedb:00000041-a-1#3184,NA,NA,p.Arg211Phe,-0.185531874,2.31e-25,3.56e-49,0.185531874 +urn:mavedb:00000041-a-1#3185,NA,NA,p.Arg211Met,-0.202207874,8.640000000000002e-09,4.6899999999999995e-17,0.202207874 +urn:mavedb:00000041-a-1#3186,NA,NA,p.Arg211Lys,0.179981466,1.8e-23,1.6599999999999998e-45,-0.179981466 +urn:mavedb:00000041-a-1#3187,NA,NA,p.Arg211Leu,-0.153685867,1.0199999999999994e-140,2.5399999999999967e-275,0.153685867 +urn:mavedb:00000041-a-1#3188,NA,NA,p.Arg211Ile,-0.360581638,2.24e-48,2.929999999999999e-94,0.360581638 +urn:mavedb:00000041-a-1#3189,NA,NA,p.Arg211His,-0.132029337,7.140000000000001e-25,3.119999999999999e-48,0.132029337 +urn:mavedb:00000041-a-1#3190,NA,NA,p.Arg211Gly,0.321986474,1.32e-18,5e-36,-0.321986474 +urn:mavedb:00000041-a-1#3191,NA,NA,p.Arg211Glu,0.302566409,2.5799999999999997e-62,1.39e-121,-0.302566409 +urn:mavedb:00000041-a-1#3192,NA,NA,p.Arg211Gln,0.126186773,0.126079267,6.94e-18,-0.126186773 +urn:mavedb:00000041-a-1#3193,NA,NA,p.Arg211Cys,0.057815777,7.820000000000001e-20,2.1399999999999996e-38,-0.057815777 +urn:mavedb:00000041-a-1#3194,NA,NA,p.Arg211Asp,0.189914525,8.82e-32,9.559999999999995e-62,-0.189914525 +urn:mavedb:00000041-a-1#3195,NA,NA,p.Arg211Ala,0.137132311,0.093235214,0.0,-0.137132311 +urn:mavedb:00000041-a-1#3196,NA,NA,p.Arg203Thr,0.213780559,1.59e-08,1.54e-16,-0.213780559 +urn:mavedb:00000041-a-1#3197,NA,NA,p.Arg203Ser,0.135540319,1.3799999999999994e-86,3.4799999999999974e-169,-0.135540319 +urn:mavedb:00000041-a-1#3198,NA,NA,p.Arg203Pro,-0.333633689,1.36e-09,1.37e-18,0.333633689 +urn:mavedb:00000041-a-1#3199,NA,NA,p.Arg203Met,-0.496959582,3.74e-17,3.6299999999999996e-33,0.496959582 +urn:mavedb:00000041-a-1#3200,NA,NA,p.Arg203His,-0.480811432,4.29e-42,6.179999999999998e-82,0.480811432 +urn:mavedb:00000041-a-1#3201,NA,NA,p.Arg203Gly,0.075790521,1.95e-09,2.82e-18,-0.075790521 +urn:mavedb:00000041-a-1#3202,NA,NA,p.Arg203Gln,-0.193580242,0.247599597,0.0,0.193580242 +urn:mavedb:00000041-a-1#3203,NA,NA,p.Arg203Cys,-0.188133355,0.015293858,1.52e-05,0.188133355 +urn:mavedb:00000041-a-1#3204,NA,NA,p.Arg203Ala,0.216564624,0.046506852,0.0,-0.216564624 +urn:mavedb:00000041-a-1#3205,NA,NA,p.Arg194Val,-0.498835626,0.284867842,3.11e-08,0.498835626 +urn:mavedb:00000041-a-1#3206,NA,NA,p.Arg194Thr,0.055684887,5.62e-17,7.69e-33,-0.055684887 +urn:mavedb:00000041-a-1#3207,NA,NA,p.Arg194Ser,-0.039181496,0.032912521,3.52e-05,0.039181496 +urn:mavedb:00000041-a-1#3208,NA,NA,p.Arg194Phe,0.426890206,2.94e-17,2.24e-33,-0.426890206 +urn:mavedb:00000041-a-1#3209,NA,NA,p.Arg194Lys,0.291934329,0.402028095,2.78e-17,-0.291934329 +urn:mavedb:00000041-a-1#3210,NA,NA,p.Arg194Leu,-0.003220098,2.34e-16,1.2e-31,0.003220098 +urn:mavedb:00000041-a-1#3211,NA,NA,p.Arg194His,0.294268496,2.77e-32,9.909999999999996e-63,-0.294268496 +urn:mavedb:00000041-a-1#3212,NA,NA,p.Arg194Gly,0.186238659,1.57e-32,3.2599999999999996e-63,-0.186238659 +urn:mavedb:00000041-a-1#3213,NA,NA,p.Arg194Gln,-0.211524116,0.067274209,4.68e-06,0.211524116 +urn:mavedb:00000041-a-1#3214,NA,NA,p.Arg194Ala,0.094629326,0.173926925,9.44e-16,-0.094629326 +urn:mavedb:00000041-a-1#3215,NA,NA,p.Arg172Val,0.127731048,0.195427448,1.39e-17,-0.127731048 +urn:mavedb:00000041-a-1#3216,NA,NA,p.Arg172Thr,0.189130142,6.04e-18,1.02e-34,-0.189130142 +urn:mavedb:00000041-a-1#3217,NA,NA,p.Arg172Ser,-0.522698157,2.5799999999999992e-70,2.909999999999999e-137,0.522698157 +urn:mavedb:00000041-a-1#3218,NA,NA,p.Arg172Lys,0.308408255,1.17e-60,2.5299999999999987e-118,-0.308408255 +urn:mavedb:00000041-a-1#3219,NA,NA,p.Arg172Ile,0.114101853,3.3e-35,1.8399999999999996e-68,-0.114101853 +urn:mavedb:00000041-a-1#3220,NA,NA,p.Arg172His,-0.408854591,1.11e-18,3.93e-36,0.408854591 +urn:mavedb:00000041-a-1#3221,NA,NA,p.Arg172Gly,-0.183177602,0.14582772800000002,3.03e-07,0.183177602 +urn:mavedb:00000041-a-1#3222,NA,NA,p.Arg172Cys,0.269305025,8.619999999999997e-12,8.549999999999998e-23,-0.269305025 +urn:mavedb:00000041-a-1#3223,NA,NA,p.Arg153Thr,0.181469342,6.7799999999999985e-09,3.03e-17,-0.181469342 +urn:mavedb:00000041-a-1#3224,NA,NA,p.Arg153Pro,0.030835044,0.267890734,2.78e-17,-0.030835044 +urn:mavedb:00000041-a-1#3225,NA,NA,p.Arg153Lys,0.05915725700000001,3.929999999999998e-21,6.07e-41,-0.05915725700000001 +urn:mavedb:00000041-a-1#3226,NA,NA,p.Arg153His,-0.065728173,9.62e-10,7.71e-19,0.065728173 +urn:mavedb:00000041-a-1#3227,NA,NA,p.Arg153Gly,-0.106052902,0.0017781029999999996,9.61e-08,0.106052902 +urn:mavedb:00000041-a-1#3228,NA,NA,p.Arg153Cys,0.236752002,0.485841759,0.0,-0.236752002 +urn:mavedb:00000041-a-1#3229,NA,NA,p.Arg153Asn,0.440797698,2.16e-58,6.689999999999997e-114,-0.440797698 +urn:mavedb:00000041-a-1#3230,NA,NA,p.Arg119Val,0.412033971,0.453976556,2.47e-10,-0.412033971 +urn:mavedb:00000041-a-1#3231,NA,NA,p.Arg113Val,-0.36639122,3.51e-23,6.29e-45,0.36639122 +urn:mavedb:00000041-a-1#3232,NA,NA,p.Arg113Thr,-0.455484497,4.53e-22,9.599999999999999e-43,0.455484497 +urn:mavedb:00000041-a-1#3233,NA,NA,p.Arg113Ser,-0.34963089700000005,3.4299999999999996e-23,6.159999999999999e-45,0.34963089700000005 +urn:mavedb:00000041-a-1#3234,NA,NA,p.Arg113Met,-0.100314977,2.74e-36,1.3899999999999999e-70,0.100314977 +urn:mavedb:00000041-a-1#3235,NA,NA,p.Arg113Lys,-0.157649375,6.149999999999999e-42,1.21e-81,0.157649375 +urn:mavedb:00000041-a-1#3236,NA,NA,p.Arg113Leu,-0.142441564,2.33e-08,2.83e-16,0.142441564 +urn:mavedb:00000041-a-1#3237,NA,NA,p.Arg113Ile,0.32350607600000003,2.8e-28,6.819999999999998e-55,-0.32350607600000003 +urn:mavedb:00000041-a-1#3238,NA,NA,p.Arg113Gly,-0.303281903,3.2399999999999998e-15,2.06e-29,0.303281903 +urn:mavedb:00000041-a-1#3239,NA,NA,p.Arg113Asn,-0.268142839,3.6900000000000005e-26,9.499999999999999e-51,0.268142839 +urn:mavedb:00000041-a-1#3240,NA,NA,p.Arg113Ala,-0.251760964,2.1e-10,4.24e-20,0.251760964 +urn:mavedb:00000041-a-1#3241,NA,NA,p.Arg93Tyr,0.083429285,1.1900000000000002e-13,2.25e-26,-0.083429285 +urn:mavedb:00000041-a-1#3242,NA,NA,p.Arg93Trp,-0.039418151,3.64e-13,1.84e-25,0.039418151 +urn:mavedb:00000041-a-1#3243,NA,NA,p.Arg93Met,0.252538878,0.367158171,0.0,-0.252538878 +urn:mavedb:00000041-a-1#3244,NA,NA,p.Arg93Lys,0.247956139,3.689999999999999e-27,1.0499999999999997e-52,-0.247956139 +urn:mavedb:00000041-a-1#3245,NA,NA,p.Arg52Tyr,0.12680722,7.72e-40,1.5599999999999991e-77,-0.12680722 +urn:mavedb:00000041-a-1#3246,NA,NA,p.Arg52Trp,-0.542523391,0.647365833,0.0,0.542523391 +urn:mavedb:00000041-a-1#3247,NA,NA,p.Arg52Thr,-0.449764614,4.74e-20,7.86e-39,0.449764614 +urn:mavedb:00000041-a-1#3250,NA,NA,p.Arg52Lys,0.14714523699999998,0.94008329,3.33e-16,-0.14714523699999998 +urn:mavedb:00000041-a-1#3251,NA,NA,p.Arg52His,-0.567352748,8.72e-05,1.29e-09,0.567352748 +urn:mavedb:00000041-a-1#3252,NA,NA,p.Arg52Ala,-0.627256124,6.96e-29,4.56e-56,0.627256124 +urn:mavedb:00000041-a-1#3253,NA,NA,p.Arg25Val,-0.094306434,0.24704253,0.0,0.094306434 +urn:mavedb:00000041-a-1#3254,NA,NA,p.Arg25Tyr,-0.408901688,1.83e-29,3.3399999999999996e-57,0.408901688 +urn:mavedb:00000041-a-1#3255,NA,NA,p.Arg25Trp,-0.302300082,6.52e-05,1.07e-09,0.302300082 +urn:mavedb:00000041-a-1#3256,NA,NA,p.Arg25Thr,-0.233934417,0.612445224,0.0,0.233934417 +urn:mavedb:00000041-a-1#3257,NA,NA,p.Arg25Ser,-0.17260408,0.364802756,0.0,0.17260408 +urn:mavedb:00000041-a-1#3258,NA,NA,p.Arg25Pro,-0.240698903,0.222839131,1.55e-15,0.240698903 +urn:mavedb:00000041-a-1#3259,NA,NA,p.Arg25Phe,-0.056810453,1.4999999999999995e-46,1.1299999999999999e-90,0.056810453 +urn:mavedb:00000041-a-1#3260,NA,NA,p.Arg25Met,-0.05759923700000001,2.32e-27,4.259999999999998e-53,0.05759923700000001 +urn:mavedb:00000041-a-1#3261,NA,NA,p.Arg25Lys,-0.475052439,0.29988870100000004,1.47e-13,0.475052439 +urn:mavedb:00000041-a-1#3262,NA,NA,p.Arg25Leu,-0.345827911,1.15e-21,5.7299999999999986e-42,0.345827911 +urn:mavedb:00000041-a-1#3263,NA,NA,p.Arg25Ile,-0.35353194600000004,4.62e-16,4.7499999999999995e-31,0.35353194600000004 +urn:mavedb:00000041-a-1#3264,NA,NA,p.Arg25His,-0.324880178,7.69e-06,1.75e-11,0.324880178 +urn:mavedb:00000041-a-1#3265,NA,NA,p.Arg25Gly,-0.13400606199999998,4.189999999999998e-37,3.4899999999999997e-72,0.13400606199999998 +urn:mavedb:00000041-a-1#3266,NA,NA,p.Arg25Glu,0.129626424,1.94e-08,2.3e-16,-0.129626424 +urn:mavedb:00000041-a-1#3267,NA,NA,p.Arg25Gln,0.266935833,0.143812165,7.72e-09,-0.266935833 +urn:mavedb:00000041-a-1#3268,NA,NA,p.Arg25Cys,-0.0554942,0.453249939,2.78e-17,0.0554942 +urn:mavedb:00000041-a-1#3269,NA,NA,p.Arg25Asp,0.061149868,0.455097668,0.0,-0.061149868 +urn:mavedb:00000041-a-1#3270,NA,NA,p.Arg25Asn,-0.446386957,4.04e-19,5.3599999999999995e-37,0.446386957 +urn:mavedb:00000041-a-1#3271,NA,NA,p.Arg25Ala,0.118705217,0.188225992,2.0800000000000003e-17,-0.118705217 +urn:mavedb:00000041-a-1#3272,NA,NA,p.Arg2Val,0.150181956,8.9e-08,3.820000000000001e-15,-0.150181956 +urn:mavedb:00000041-a-1#3273,NA,NA,p.Arg2Ser,0.315680621,0.07827050599999999,1.2e-07,-0.315680621 +urn:mavedb:00000041-a-1#3274,NA,NA,p.Arg2Lys,0.043717502000000005,4.4900000000000005e-08,1.0599999999999999e-15,-0.043717502000000005 +urn:mavedb:00000041-a-1#3275,NA,NA,p.Arg2Gly,0.211541371,1.6599999999999994e-48,1.6699999999999994e-94,-0.211541371 +urn:mavedb:00000041-a-1#3276,NA,NA,p.Arg2Gln,0.386945172,0.226492135,0.0,-0.386945172 +urn:mavedb:00000041-a-1#3277,NA,NA,p.Arg2Asp,0.404528845,0.375712616,0.0,-0.404528845 +urn:mavedb:00000041-a-1#3278,NA,NA,p.Arg2Ala,0.247077672,1.32e-35,3.0199999999999996e-69,-0.247077672 +urn:mavedb:00000041-a-1#3279,NA,NA,p.Thr23Ala,0.12524133,9.219999999999994e-78,7.099999999999995e-152,-0.12524133 +urn:mavedb:00000041-a-1#3280,NA,NA,p.Thr19Val,-0.420081019,2.0199999999999998e-32,5.289999999999997e-63,0.420081019 +urn:mavedb:00000041-a-1#3281,NA,NA,p.Thr19Tyr,0.001048931,0.35350967,6.94e-17,-0.001048931 +urn:mavedb:00000041-a-1#3282,NA,NA,p.Thr19Trp,-0.298280723,0.252569736,0.0,0.298280723 +urn:mavedb:00000041-a-1#3283,NA,NA,p.Thr19Ser,0.151440015,0.00032639400000000003,5.06e-09,-0.151440015 +urn:mavedb:00000041-a-1#3284,NA,NA,p.Thr19Pro,-0.094435371,2.15e-39,1.1599999999999993e-76,0.094435371 +urn:mavedb:00000041-a-1#3285,NA,NA,p.Thr19Phe,-0.094793624,9.869999999999994e-104,8.359999999999991e-203,0.094793624 +urn:mavedb:00000041-a-1#3286,NA,NA,p.Thr19Met,-0.345470513,0.197677085,1.02e-12,0.345470513 +urn:mavedb:00000041-a-1#3287,NA,NA,p.Thr19Lys,-0.07903418799999999,0.149804983,1.73e-08,0.07903418799999999 +urn:mavedb:00000041-a-1#3288,NA,NA,p.Thr19Leu,-0.290623679,8.36e-24,3.83e-46,0.290623679 +urn:mavedb:00000041-a-1#3289,NA,NA,p.Thr19Ile,-0.291234991,0.006743071999999999,6.4e-07,0.291234991 +urn:mavedb:00000041-a-1#3290,NA,NA,p.Thr19His,-0.088677594,3.02e-35,1.569999999999999e-68,0.088677594 +urn:mavedb:00000041-a-1#3291,NA,NA,p.Thr19Gly,-0.368038901,1.6299999999999997e-42,9.009999999999993e-83,0.368038901 +urn:mavedb:00000041-a-1#3292,NA,NA,p.Thr19Glu,-0.476046009,0.163539455,4.55e-10,0.476046009 +urn:mavedb:00000041-a-1#3293,NA,NA,p.Thr19Gln,-0.427614424,1.34e-46,8.979999999999997e-91,0.427614424 +urn:mavedb:00000041-a-1#3294,NA,NA,p.Thr19Cys,-0.347260777,4.839999999999998e-112,4.219999999999998e-219,0.347260777 +urn:mavedb:00000041-a-1#3295,NA,NA,p.Thr19Asp,-0.268043066,0.293258399,0.0,0.268043066 +urn:mavedb:00000041-a-1#3296,NA,NA,p.Thr19Asn,0.392970002,0.20751098,0.0,-0.392970002 +urn:mavedb:00000041-a-1#3297,NA,NA,p.Leu7Tyr,0.205315608,0.513593657,1.11e-16,-0.205315608 +urn:mavedb:00000041-a-1#3298,NA,NA,p.Leu7Glu,0.163047467,0.327348668,2.78e-17,-0.163047467 +urn:mavedb:00000041-a-1#3299,NA,NA,p.Leu7Asp,-0.381816431,1.0199999999999999e-52,9.25e-103,0.381816431 +urn:mavedb:00000041-a-1#3300,NA,NA,p.Leu7Arg,-0.081400287,1.43e-06,7.890000000000001e-13,0.081400287 +urn:mavedb:00000041-a-1#3301,NA,NA,p.Leu1Thr,-0.5005525829999999,2.95e-44,3.67e-86,0.5005525829999999 +urn:mavedb:00000041-a-1#3302,NA,NA,p.Ile184Val,-0.301731697,3.92e-44,6.009999999999998e-86,0.301731697 +urn:mavedb:00000041-a-1#3303,NA,NA,p.Ile184Tyr,0.131483199,8.729999999999998e-44,3.039999999999998e-85,-0.131483199 +urn:mavedb:00000041-a-1#3304,NA,NA,p.Ile184Cys,-0.117646173,8.880000000000001e-21,3.17e-40,0.117646173 +urn:mavedb:00000041-a-1#3305,NA,NA,p.Ile175Asn,-0.431056504,0.672711272,0.0,0.431056504 +urn:mavedb:00000041-a-1#3306,NA,NA,p.Ile160Tyr,-0.043717028,0.349643251,6.470000000000001e-11,0.043717028 +urn:mavedb:00000041-a-1#3307,NA,NA,p.Ile160Phe,-0.295534492,0.792938563,0.0,0.295534492 +urn:mavedb:00000041-a-1#3308,NA,NA,p.Ile160Leu,0.366858825,1.85e-06,1.17e-12,-0.366858825 +urn:mavedb:00000041-a-1#3309,NA,NA,p.Ile145Val,0.038074213,4.979999999999999e-51,1.889999999999999e-99,-0.038074213 +urn:mavedb:00000041-a-1#3313,NA,NA,p.Ile104Cys,0.3842569220000001,6.2e-12,4.65e-23,-0.3842569220000001 +urn:mavedb:00000041-a-1#3314,NA,NA,p.Ile70Leu,0.29916454800000003,0.082899661,0.000272869,-0.29916454800000003 +urn:mavedb:00000041-a-1#3315,NA,NA,p.Ile70His,-0.315914374,0.100514998,2.26e-08,0.315914374 +urn:mavedb:00000041-a-1#3316,NA,NA,p.Ile68Ser,0.111719281,0.121480797,0.000139568,-0.111719281 +urn:mavedb:00000041-a-1#3317,NA,NA,p.Ile68Met,0.260209711,0.538124071,1.02e-14,-0.260209711 +urn:mavedb:00000041-a-1#3318,NA,NA,p.Ile68Gly,0.140347122,4.3100000000000005e-11,2.09e-21,-0.140347122 +urn:mavedb:00000041-a-1#3319,NA,NA,p.Ile28Val,-0.530795541,1.07e-24,6.859999999999998e-48,0.530795541 +urn:mavedb:00000041-a-1#3320,NA,NA,p.Ile28Tyr,-0.038643135,0.198491837,0.0,0.038643135 +urn:mavedb:00000041-a-1#3321,NA,NA,p.Ile28Thr,-0.511232445,1.57e-26,1.81e-51,0.511232445 +urn:mavedb:00000041-a-1#3322,NA,NA,p.Ile28Ser,-0.582269864,1.01e-07,5.2200000000000004e-15,0.582269864 +urn:mavedb:00000041-a-1#3323,NA,NA,p.Ile28Phe,0.186413049,0.076931347,4.47e-07,-0.186413049 +urn:mavedb:00000041-a-1#3324,NA,NA,p.Ile28Leu,0.054048340999999986,0.29308749,0.0,-0.054048340999999986 +urn:mavedb:00000041-a-1#3325,NA,NA,p.Ile28Gly,-0.281915185,1.56e-12,3.2700000000000003e-24,0.281915185 +urn:mavedb:00000041-a-1#3326,NA,NA,p.Ile28Cys,-0.475024884,0.000324801,2.12e-08,0.475024884 +urn:mavedb:00000041-a-1#3327,NA,NA,p.His226Trp,0.065928635,2.54e-26,4.6899999999999986e-51,-0.065928635 +urn:mavedb:00000041-a-1#3328,NA,NA,p.His226Thr,0.326288367,7.8e-37,1.2299999999999999e-71,-0.326288367 +urn:mavedb:00000041-a-1#3329,NA,NA,p.His226Ser,-0.107903087,0.166575107,0.0,0.107903087 +urn:mavedb:00000041-a-1#3330,NA,NA,p.His226Met,0.064565245,3.68e-07,5.84e-14,-0.064565245 +urn:mavedb:00000041-a-1#3331,NA,NA,p.His226Lys,-0.25566245600000004,0.099109067,9.5e-08,0.25566245600000004 +urn:mavedb:00000041-a-1#3332,NA,NA,p.His226Gly,-0.021096165,2.98e-06,2.34e-12,0.021096165 +urn:mavedb:00000041-a-1#3333,NA,NA,p.His226Glu,0.191920169,0.125261294,3.7400000000000014e-12,-0.191920169 +urn:mavedb:00000041-a-1#3334,NA,NA,p.His226Gln,0.105823766,0.362322074,3.89e-16,-0.105823766 +urn:mavedb:00000041-a-1#3335,NA,NA,p.His226Cys,0.249121287,1.1399999999999999e-24,7.969999999999999e-48,-0.249121287 +urn:mavedb:00000041-a-1#3336,NA,NA,p.His226Asp,-0.004324175,1.16e-18,4.08e-36,0.004324175 +urn:mavedb:00000041-a-1#3337,NA,NA,p.His226Asn,-0.288943591,2.95e-30,9.019999999999999e-59,0.288943591 +urn:mavedb:00000041-a-1#3338,NA,NA,p.His226Arg,-0.05120058,8.26e-12,7.79e-23,0.05120058 +urn:mavedb:00000041-a-1#3339,NA,NA,p.His226Ala,-0.041150804,1.85e-19,1.1199999999999996e-37,0.041150804 +urn:mavedb:00000041-a-1#3340,NA,NA,p.Gly212Asp,0.345806459,5.79e-35,5.579999999999998e-68,-0.345806459 +urn:mavedb:00000041-a-1#3341,NA,NA,p.Gly212Asn,0.27210274,0.245204007,0.0,-0.27210274 +urn:mavedb:00000041-a-1#3342,NA,NA,p.Gly199Thr,-0.173431677,0.64636952,2.22e-16,0.173431677 +urn:mavedb:00000041-a-1#3344,NA,NA,p.Gly199Ala,-0.5839288420000001,5.73e-21,1.38e-40,0.5839288420000001 +urn:mavedb:00000041-a-1#3345,NA,NA,p.Gly171Trp,0.140237741,0.337807014,1.39e-17,-0.140237741 +urn:mavedb:00000041-a-1#3346,NA,NA,p.Gly171Phe,-0.327421085,1.26e-09,1.31e-18,0.327421085 +urn:mavedb:00000041-a-1#3347,NA,NA,p.Gly171Met,-0.34680124,1.6300000000000003e-23,1.4e-45,0.34680124 +urn:mavedb:00000041-a-1#3348,NA,NA,p.Gly171His,0.039436337,1.1e-24,7.259999999999999e-48,-0.039436337 +urn:mavedb:00000041-a-1#3349,NA,NA,p.Gly171Arg,0.289256148,7.96e-05,9.89e-10,-0.289256148 +urn:mavedb:00000041-a-1#3350,NA,NA,p.Gly155Asp,0.294664721,2.6e-20,2.4799999999999998e-39,-0.294664721 +urn:mavedb:00000041-a-1#3351,NA,NA,p.Gly129Thr,-0.088022256,0.225128259,0.0,0.088022256 +urn:mavedb:00000041-a-1#3352,NA,NA,p.Gly129Ser,-0.435985582,3.78e-16,3.16e-31,0.435985582 +urn:mavedb:00000041-a-1#3353,NA,NA,p.Gly129Met,-0.097412337,9.45e-15,1.56e-28,0.097412337 +urn:mavedb:00000041-a-1#3354,NA,NA,p.Gly129His,-0.288932656,6.949999999999997e-75,3.009999999999998e-146,0.288932656 +urn:mavedb:00000041-a-1#3355,NA,NA,p.Gly129Glu,0.388977634,3.1499999999999996e-47,5.339999999999998e-92,-0.388977634 +urn:mavedb:00000041-a-1#3356,NA,NA,p.Gly129Arg,-0.590611425,1.02e-07,5.45e-15,0.590611425 +urn:mavedb:00000041-a-1#3357,NA,NA,p.Gly129Ala,0.363230303,1.33e-20,7.07e-40,-0.363230303 +urn:mavedb:00000041-a-1#3358,NA,NA,p.Gly89Val,0.109580526,3.1e-15,1.99e-29,-0.109580526 +urn:mavedb:00000041-a-1#3359,NA,NA,p.Gly89Trp,-0.000943394,0.17862851,0.0,0.000943394 +urn:mavedb:00000041-a-1#3360,NA,NA,p.Gly86Val,0.276532212,2.1e-48,2.5499999999999996e-94,-0.276532212 +urn:mavedb:00000041-a-1#3361,NA,NA,p.Gly86Trp,-0.146416321,1.33e-20,6.879999999999999e-40,0.146416321 +urn:mavedb:00000041-a-1#3362,NA,NA,p.Gly86Thr,0.024806569,0.109573658,3.47e-18,-0.024806569 +urn:mavedb:00000041-a-1#3363,NA,NA,p.Gly86Ser,-0.190487317,1.87e-24,2.03e-47,0.190487317 +urn:mavedb:00000041-a-1#3364,NA,NA,p.Gly86Pro,0.075131827,4.64e-14,3.3e-27,-0.075131827 +urn:mavedb:00000041-a-1#3365,NA,NA,p.Gly86Phe,-0.249419217,0.481721517,0.0,0.249419217 +urn:mavedb:00000041-a-1#3366,NA,NA,p.Gly86Lys,0.037702163,0.156862935,4.12e-06,-0.037702163 +urn:mavedb:00000041-a-1#3367,NA,NA,p.Gly86Leu,0.125406612,9.08e-07,2.9600000000000005e-13,-0.125406612 +urn:mavedb:00000041-a-1#3368,NA,NA,p.Gly86Ile,0.149640923,0.00057031,1.82e-08,-0.149640923 +urn:mavedb:00000041-a-1#3369,NA,NA,p.Gly86His,-0.398375921,1.5599999999999994e-48,1.4199999999999994e-94,0.398375921 +urn:mavedb:00000041-a-1#3370,NA,NA,p.Gly86Glu,0.032487766,0.030668308,2.54e-05,-0.032487766 +urn:mavedb:00000041-a-1#3371,NA,NA,p.Gly86Gln,0.237242328,1.7900000000000001e-40,8.999999999999997e-79,-0.237242328 +urn:mavedb:00000041-a-1#3372,NA,NA,p.Gly86Cys,-0.226646726,0.25578518100000003,0.0,0.226646726 +urn:mavedb:00000041-a-1#3373,NA,NA,p.Gly86Asn,0.286514708,0.003561303,3.3e-07,-0.286514708 +urn:mavedb:00000041-a-1#3374,NA,NA,p.Gly86Arg,-0.191980122,2.05e-07,1.82e-14,0.191980122 +urn:mavedb:00000041-a-1#3376,NA,NA,p.Gly78Ser,0.063608888,1.2199999999999999e-36,2.75e-71,-0.063608888 +urn:mavedb:00000041-a-1#3377,NA,NA,p.Gly78Lys,0.059550171,3.77e-17,3.6099999999999996e-33,-0.059550171 +urn:mavedb:00000041-a-1#3378,NA,NA,p.Gly78Leu,0.039164347,0.055242969,0.0,-0.039164347 +urn:mavedb:00000041-a-1#3379,NA,NA,p.Gly78Cys,0.275529742,0.162406805,4.42e-09,-0.275529742 +urn:mavedb:00000041-a-1#3380,NA,NA,p.Gly78Asn,0.220244173,0.16489638,1.19e-08,-0.220244173 +urn:mavedb:00000041-a-1#3381,NA,NA,p.Gly78Arg,-0.04371402,0.385823769,0.0,0.04371402 +urn:mavedb:00000041-a-1#3382,NA,NA,p.Gly34Leu,-0.019340811,0.178738808,0.0,0.019340811 +urn:mavedb:00000041-a-1#3383,NA,NA,p.Gly22Val,-0.277643089,0.000157293,2.6100000000000003e-09,0.277643089 +urn:mavedb:00000041-a-1#3384,NA,NA,p.Gly22Ser,-0.069910439,4.2e-16,3.5399999999999997e-31,0.069910439 +urn:mavedb:00000041-a-1#3385,NA,NA,p.Gly22Met,-0.026648104,0.006465091,3.62e-08,0.026648104 +urn:mavedb:00000041-a-1#3386,NA,NA,p.Gly22Leu,-0.19457462600000006,4.650000000000002e-16,4.77e-31,0.19457462600000006 +urn:mavedb:00000041-a-1#3387,NA,NA,p.Gly22Ile,0.122829832,6.149999999999997e-106,4.0399999999999974e-207,-0.122829832 +urn:mavedb:00000041-a-1#3388,NA,NA,p.Gly22His,-0.154924294,0.0052856430000000005,7.57e-08,0.154924294 +urn:mavedb:00000041-a-1#3389,NA,NA,p.Gly22Glu,-0.030993865,2.4e-26,4.12e-51,0.030993865 +urn:mavedb:00000041-a-1#3390,NA,NA,p.Gly22Gln,-0.023495511,4.96e-32,2.939999999999999e-62,0.023495511 +urn:mavedb:00000041-a-1#3391,NA,NA,p.Gly22Cys,0.08280768,4.29e-47,9.96e-92,-0.08280768 +urn:mavedb:00000041-a-1#3392,NA,NA,p.Gly22Asp,-0.138499197,9.759999999999999e-16,2.08e-30,0.138499197 +urn:mavedb:00000041-a-1#3393,NA,NA,p.Gly22Asn,-0.037742982,5.07e-06,8.619999999999997e-12,0.037742982 +urn:mavedb:00000041-a-1#3394,NA,NA,p.Gly22Arg,-0.16413081599999998,1.51e-07,1.09e-14,0.16413081599999998 +urn:mavedb:00000041-a-1#3395,NA,NA,p.Gly22Ala,-0.370100895,1.22e-34,2.3699999999999997e-67,0.370100895 +urn:mavedb:00000041-a-1#3396,NA,NA,p.Gly18Tyr,-0.348567343,0.28730051,4.370000000000001e-13,0.348567343 +urn:mavedb:00000041-a-1#3397,NA,NA,p.Gly18Thr,0.257915651,0.055754615,7.2e-05,-0.257915651 +urn:mavedb:00000041-a-1#3398,NA,NA,p.Gly18Met,0.14222368,0.323471625,0.0,-0.14222368 +urn:mavedb:00000041-a-1#3399,NA,NA,p.Gly18Cys,0.26001152,0.135167807,7.52e-14,-0.26001152 +urn:mavedb:00000041-a-1#3400,NA,NA,p.Gly18Ala,-0.627657449,0.163985303,6.709999999999999e-07,0.627657449 +urn:mavedb:00000041-a-1#3401,NA,NA,p.Glu244Val,-0.461049545,1.97e-11,4.459999999999998e-22,0.461049545 +urn:mavedb:00000041-a-1#3402,NA,NA,p.Glu244Trp,-0.580210886,3.2e-05,2.37e-10,0.580210886 +urn:mavedb:00000041-a-1#3403,NA,NA,p.Glu244Ser,-0.233074182,3.56e-23,6.18e-45,0.233074182 +urn:mavedb:00000041-a-1#3404,NA,NA,p.Glu244Phe,-0.009766137,0.769032539,0.0,0.009766137 +urn:mavedb:00000041-a-1#3405,NA,NA,p.Glu244Lys,-0.162857949,2.58e-24,3.8299999999999995e-47,0.162857949 +urn:mavedb:00000041-a-1#3408,NA,NA,p.Glu244Gly,-0.300968612,2.0299999999999996e-32,5.059999999999998e-63,0.300968612 +urn:mavedb:00000041-a-1#3409,NA,NA,p.Glu244Gln,0.195791114,0.321157352,0.0,-0.195791114 +urn:mavedb:00000041-a-1#3410,NA,NA,p.Glu244Cys,0.036534057,1.4899999999999998e-28,1.88e-55,-0.036534057 +urn:mavedb:00000041-a-1#3411,NA,NA,p.Glu244Asp,-0.16620181,3.27e-18,3.0999999999999996e-35,0.16620181 +urn:mavedb:00000041-a-1#3412,NA,NA,p.Glu244Asn,-0.514709839,4.67e-14,3.65e-27,0.514709839 +urn:mavedb:00000041-a-1#3413,NA,NA,p.Glu239Val,-0.247721209,1.54e-51,1.8399999999999997e-100,0.247721209 +urn:mavedb:00000041-a-1#3414,NA,NA,p.Glu239Thr,-0.245327083,3.1e-12,1.19e-23,0.245327083 +urn:mavedb:00000041-a-1#3415,NA,NA,p.Glu239Ser,-0.083668023,0.133308085,3.47e-18,0.083668023 +urn:mavedb:00000041-a-1#3416,NA,NA,p.Glu239Met,-0.401341943,0.269458059,1.57e-06,0.401341943 +urn:mavedb:00000041-a-1#3417,NA,NA,p.Glu239Lys,-0.56155195,3.24e-14,1.8899999999999997e-27,0.56155195 +urn:mavedb:00000041-a-1#3418,NA,NA,p.Glu239Leu,-0.35106740299999994,7.41e-12,6.66e-23,0.35106740299999994 +urn:mavedb:00000041-a-1#3419,NA,NA,p.Glu239Ile,-0.34653797299999994,3.3499999999999996e-30,1.18e-58,0.34653797299999994 +urn:mavedb:00000041-a-1#3420,NA,NA,p.Glu239Gly,-0.465415244,0.141627405,1.39e-17,0.465415244 +urn:mavedb:00000041-a-1#3421,NA,NA,p.Glu239Gln,-0.531826997,0.037230642,9.990000000000003e-05,0.531826997 +urn:mavedb:00000041-a-1#3422,NA,NA,p.Glu239Asn,-0.12903765,0.000458564,8.51e-09,0.12903765 +urn:mavedb:00000041-a-1#3423,NA,NA,p.Glu239Ala,-0.216385733,6.47e-30,4.25e-58,0.216385733 +urn:mavedb:00000041-a-1#3424,NA,NA,p.Glu238Trp,-0.564979071,2e-17,1.07e-33,0.564979071 +urn:mavedb:00000041-a-1#3425,NA,NA,p.Glu238Thr,0.054103193,0.346440507,1.39e-17,-0.054103193 +urn:mavedb:00000041-a-1#3426,NA,NA,p.Glu238Ser,-0.317166374,0.008200757,2.72e-07,0.317166374 +urn:mavedb:00000041-a-1#3427,NA,NA,p.Glu238Pro,-0.454988251,6.240000000000001e-26,2.6899999999999997e-50,0.454988251 +urn:mavedb:00000041-a-1#3428,NA,NA,p.Glu238Met,0.060840948,7.13e-18,1.4099999999999996e-34,-0.060840948 +urn:mavedb:00000041-a-1#3429,NA,NA,p.Glu238Leu,-0.261010173,2.57e-35,1.1499999999999996e-68,0.261010173 +urn:mavedb:00000041-a-1#3430,NA,NA,p.Glu238His,-0.255436212,0.110664563,0.0,0.255436212 +urn:mavedb:00000041-a-1#3431,NA,NA,p.Glu238Gly,-0.134433892,1.1499999999999998e-34,2.119999999999999e-67,0.134433892 +urn:mavedb:00000041-a-1#3432,NA,NA,p.Glu238Asp,-0.5678080879999999,0.574204238,0.0,0.5678080879999999 +urn:mavedb:00000041-a-1#3433,NA,NA,p.Glu238Asn,0.100010022,1.57e-35,4.4999999999999996e-69,-0.100010022 +urn:mavedb:00000041-a-1#3434,NA,NA,p.Glu238Arg,-0.5661207970000001,2.35e-30,5.84e-59,0.5661207970000001 +urn:mavedb:00000041-a-1#3435,NA,NA,p.Glu238Ala,-0.249617582,0.356683049,0.0,0.249617582 +urn:mavedb:00000041-a-1#3436,NA,NA,p.Glu236Val,-0.262435366,2.15e-26,3.27e-51,0.262435366 +urn:mavedb:00000041-a-1#3437,NA,NA,p.Glu236Tyr,-0.498380875,8.069999999999997e-50,4.3499999999999983e-97,0.498380875 +urn:mavedb:00000041-a-1#3439,NA,NA,p.Glu236Ser,-0.341931764,0.219452133,7.659999999999999e-13,0.341931764 +urn:mavedb:00000041-a-1#3440,NA,NA,p.Glu236Pro,-0.145207729,0.15252351,0.0,0.145207729 +urn:mavedb:00000041-a-1#3441,NA,NA,p.Glu236Phe,0.072698587,8.31e-13,1e-24,-0.072698587 +urn:mavedb:00000041-a-1#3442,NA,NA,p.Glu236Lys,-0.148639827,0.312774502,0.0,0.148639827 +urn:mavedb:00000041-a-1#3443,NA,NA,p.Glu236Leu,-0.390671752,0.14151360300000002,1.15e-08,0.390671752 +urn:mavedb:00000041-a-1#3444,NA,NA,p.Glu236Ile,-0.190128508,1.36e-12,2.44e-24,0.190128508 +urn:mavedb:00000041-a-1#3445,NA,NA,p.Glu236His,-0.583638266,9.909999999999999e-15,1.88e-28,0.583638266 +urn:mavedb:00000041-a-1#3446,NA,NA,p.Glu236Gly,-0.187787774,6.6199999999999994e-18,1.1599999999999999e-34,0.187787774 +urn:mavedb:00000041-a-1#3447,NA,NA,p.Glu236Gln,-0.623850593,4.2899999999999995e-65,5.049999999999998e-127,0.623850593 +urn:mavedb:00000041-a-1#3448,NA,NA,p.Glu236Cys,-0.409186332,9.65e-22,4.0899999999999987e-42,0.409186332 +urn:mavedb:00000041-a-1#3449,NA,NA,p.Glu236Asp,0.004020794,1.55e-13,3.61e-26,-0.004020794 +urn:mavedb:00000041-a-1#3450,NA,NA,p.Glu236Asn,-0.400119749,3.95e-43,5.65e-84,0.400119749 +urn:mavedb:00000041-a-1#3451,NA,NA,p.Glu236Arg,-0.12760658,0.000525686,2.66e-08,0.12760658 +urn:mavedb:00000041-a-1#3452,NA,NA,p.Glu236Ala,-0.293641705,1.3e-33,2.41e-65,0.293641705 +urn:mavedb:00000041-a-1#3453,NA,NA,p.Glu223Val,-0.180690906,0.116178643,1.65e-07,0.180690906 +urn:mavedb:00000041-a-1#3454,NA,NA,p.Glu223Thr,-0.218290471,0.110301999,6.08e-09,0.218290471 +urn:mavedb:00000041-a-1#3455,NA,NA,p.Glu223Pro,-0.163492572,0.619712897,1.11e-16,0.163492572 +urn:mavedb:00000041-a-1#3456,NA,NA,p.Glu223Met,-0.356269599,9.37e-17,2.22e-32,0.356269599 +urn:mavedb:00000041-a-1#3457,NA,NA,p.Glu223Lys,-0.368210371,1.37e-116,5.389999999999994e-228,0.368210371 +urn:mavedb:00000041-a-1#3458,NA,NA,p.Glu223Gly,-0.051777381,0.4713732370000001,0.0,0.051777381 +urn:mavedb:00000041-a-1#3459,NA,NA,p.Glu223Asn,0.078040632,3.79e-13,2.13e-25,-0.078040632 +urn:mavedb:00000041-a-1#3460,NA,NA,p.Glu223Ala,-0.224783262,0.155141952,6.94e-18,0.224783262 +urn:mavedb:00000041-a-1#3461,NA,NA,p.Glu220Tyr,-0.15215634,1.3e-08,1.1299999999999999e-16,0.15215634 +urn:mavedb:00000041-a-1#3462,NA,NA,p.Glu220Thr,0.431431605,3.53e-23,6.579999999999996e-45,-0.431431605 +urn:mavedb:00000041-a-1#3463,NA,NA,p.Glu220Ser,0.236719972,1.34e-06,6.69e-13,-0.236719972 +urn:mavedb:00000041-a-1#3464,NA,NA,p.Glu220Met,0.153064013,1.37e-18,5.7999999999999996e-36,-0.153064013 +urn:mavedb:00000041-a-1#3465,NA,NA,p.Ala164Ser,-0.559582289,4.839999999999998e-93,8.009999999999993e-182,0.559582289 +urn:mavedb:00000041-a-1#3466,NA,NA,p.Ala164Gly,-0.368804119,1.3e-12,2.2799999999999998e-24,0.368804119 +urn:mavedb:00000041-a-1#3467,NA,NA,p.Ala164Glu,0.3894608,2.52e-29,6.15e-57,-0.3894608 +urn:mavedb:00000041-a-1#3468,NA,NA,p.Ala156Phe,0.398711212,9.469999999999999e-69,3.3399999999999985e-134,-0.398711212 +urn:mavedb:00000041-a-1#3469,NA,NA,p.Ala156Gly,-0.054919959,2.2200000000000003e-24,2.7399999999999997e-47,0.054919959 +urn:mavedb:00000041-a-1#3470,NA,NA,p.Ala152Cys,0.460064379,3.0099999999999997e-25,5.689999999999998e-49,-0.460064379 +urn:mavedb:00000041-a-1#3471,NA,NA,p.Ala124Val,0.440325925,6.4699999999999975e-62,8.54e-121,-0.440325925 +urn:mavedb:00000041-a-1#3472,NA,NA,p.Ala124Glu,-0.381370021,9.69e-27,6.909999999999996e-52,0.381370021 +urn:mavedb:00000041-a-1#3473,NA,NA,p.Ala123Val,0.21688523,3.47e-14,2.0999999999999998e-27,-0.21688523 +urn:mavedb:00000041-a-1#3474,NA,NA,p.Ala123Gly,0.091092802,1.71e-30,3.27e-59,-0.091092802 +urn:mavedb:00000041-a-1#3475,NA,NA,p.Ala109Ser,-0.5232212860000001,0.279372275,4.1600000000000007e-17,0.5232212860000001 +urn:mavedb:00000041-a-1#3476,NA,NA,p.Ala109Lys,-0.551747324,1.7e-07,1.58e-14,0.551747324 +urn:mavedb:00000041-a-1#3477,NA,NA,p.Ala109His,-0.495461203,0.468585489,8.33e-15,0.495461203 +urn:mavedb:00000041-a-1#3478,NA,NA,p.Ala109Cys,-0.518957443,9.83e-17,2.41e-32,0.518957443 +urn:mavedb:00000041-a-1#3479,NA,NA,p.Ala105Val,0.0750822,1.5200000000000002e-20,8.83e-40,-0.0750822 +urn:mavedb:00000041-a-1#3480,NA,NA,p.Ala105Thr,0.03970807,1.43e-11,2.26e-22,-0.03970807 +urn:mavedb:00000041-a-1#3481,NA,NA,p.Ala105Ser,-0.378026799,5.839999999999999e-07,1.31e-13,0.378026799 +urn:mavedb:00000041-a-1#3482,NA,NA,p.Ala105Leu,0.391090827,0.00049998,2.46e-08,-0.391090827 +urn:mavedb:00000041-a-1#3483,NA,NA,p.Ala105Ile,0.45463463,2.699999999999998e-115,1.869999999999998e-225,-0.45463463 +urn:mavedb:00000041-a-1#3484,NA,NA,p.Ala102Val,0.138631359,0.023937581,3.92e-05,-0.138631359 +urn:mavedb:00000041-a-1#3485,NA,NA,p.Ala102Trp,-0.092868501,0.828207933,0.0,0.092868501 +urn:mavedb:00000041-a-1#3486,NA,NA,p.Ala102Thr,-0.49061736,0.6014471339999999,0.0,0.49061736 +urn:mavedb:00000041-a-1#3487,NA,NA,p.Ala102Ser,0.059106318,0.30090657,2.78e-17,-0.059106318 +urn:mavedb:00000041-a-1#3488,NA,NA,p.Ala102Phe,0.103748662,6.01e-16,7.8400000000000005e-31,-0.103748662 +urn:mavedb:00000041-a-1#3489,NA,NA,p.Ala102Leu,0.17863613899999994,3.9200000000000005e-09,1.13e-17,-0.17863613899999994 +urn:mavedb:00000041-a-1#3490,NA,NA,p.Ala102Ile,0.359748656,7.24e-52,4.409999999999998e-101,-0.359748656 +urn:mavedb:00000041-a-1#3491,NA,NA,p.Ala102Gly,-0.312450054,6.779999999999999e-35,7.629999999999997e-68,0.312450054 +urn:mavedb:00000041-a-1#3492,NA,NA,p.Ala102Gln,-0.378164339,2.21e-08,3.12e-16,0.378164339 +urn:mavedb:00000041-a-1#3493,NA,NA,p.Ala102Asp,-0.299997924,2.2300000000000003e-27,4.01e-53,0.299997924 +urn:mavedb:00000041-a-1#3494,NA,NA,p.Ala102Arg,-0.6095105670000001,2.5799999999999997e-22,3.129999999999999e-43,0.6095105670000001 +urn:mavedb:00000041-a-1#3495,NA,NA,p.Ala101Val,-0.26754804,0.309430812,0.0,0.26754804 +urn:mavedb:00000041-a-1#886,NA,NA,p.Leu56Ter,2.055320837,0.102463493,0.000725535,-2.055320837 +urn:mavedb:00000041-a-1#887,NA,NA,p.Leu56Pro,1.314404092,9.03e-08,4.66e-15,-1.314404092 +urn:mavedb:00000041-a-1#888,NA,NA,p.Leu56Phe,1.098231541,0.416879138,0.0,-1.098231541 +urn:mavedb:00000041-a-1#889,NA,NA,p.Leu56Lys,0.691359068,1.21e-26,1.1e-51,-0.691359068 +urn:mavedb:00000041-a-1#890,NA,NA,p.Leu56His,0.6840778470000001,8.02e-15,1.2399999999999999e-28,-0.6840778470000001 +urn:mavedb:00000041-a-1#891,NA,NA,p.Leu56Gly,1.3676590780000002,3.63e-10,1.24e-19,-1.3676590780000002 +urn:mavedb:00000041-a-1#892,NA,NA,p.Leu56Glu,1.637445289,8.21e-06,2.1100000000000003e-11,-1.637445289 +urn:mavedb:00000041-a-1#893,NA,NA,p.Leu56Gln,1.33948625,4.41e-07,9.1e-14,-1.33948625 +urn:mavedb:00000041-a-1#894,NA,NA,p.Leu56Asp,1.503613809,0.002236234,2.89e-07,-1.503613809 +urn:mavedb:00000041-a-1#895,NA,NA,p.Leu56Arg,1.580804918,1.32e-10,1.8000000000000002e-20,-1.580804918 +urn:mavedb:00000041-a-1#1349,NA,NA,p.Asp120Gly,1.524647535,1.2e-06,6.01e-13,-1.524647535 +urn:mavedb:00000041-a-1#1350,NA,NA,p.Asp120Asn,1.4962438,0.000430298,2.38e-08,-1.4962438 +urn:mavedb:00000041-a-1#1351,NA,NA,p.Asp120Arg,1.4645750359999998,6.79e-10,4.17e-19,-1.4645750359999998 +urn:mavedb:00000041-a-1#1352,NA,NA,p.Asp120Ala,1.647288055,0.007355296,2.02e-07,-1.647288055 +urn:mavedb:00000041-a-1#1353,NA,NA,p.Asp99Ter,2.070264938,0.566775031,1.67e-16,-2.070264938 +urn:mavedb:00000041-a-1#1354,NA,NA,p.Asp82Val,0.610583409,2.12e-26,3.2399999999999997e-51,-0.610583409 +urn:mavedb:00000041-a-1#1355,NA,NA,p.Asp82Tyr,1.223410618,0.547008911,1.11e-16,-1.223410618 +urn:mavedb:00000041-a-1#1356,NA,NA,p.Asp82Ter,1.450709227,9.59e-11,9.82e-21,-1.450709227 +urn:mavedb:00000041-a-1#1357,NA,NA,p.Asp82Pro,1.171522175,6.85e-25,2.959999999999999e-48,-1.171522175 +urn:mavedb:00000041-a-1#1358,NA,NA,p.Asp82Met,0.6624012020000001,6.67e-09,3.08e-17,-0.6624012020000001 +urn:mavedb:00000041-a-1#1359,NA,NA,p.Asp82Lys,0.7645306279999999,2.6e-08,4.1900000000000005e-16,-0.7645306279999999 +urn:mavedb:00000041-a-1#1360,NA,NA,p.Asp82Leu,0.574051211,3.92e-14,2.5699999999999998e-27,-0.574051211 +urn:mavedb:00000041-a-1#1361,NA,NA,p.Asp82Arg,0.703674535,7.56e-20,2.0499999999999996e-38,-0.703674535 +urn:mavedb:00000041-a-1#1362,NA,NA,p.Asn202Val,1.411563958,3.78e-07,6.98e-14,-1.411563958 +urn:mavedb:00000041-a-1#1363,NA,NA,p.Asn202Tyr,1.284094397,8.36e-13,1.04e-24,-1.284094397 +urn:mavedb:00000041-a-1#1364,NA,NA,p.Asn202Trp,1.582839411,2.92e-09,6.83e-18,-1.582839411 +urn:mavedb:00000041-a-1#1365,NA,NA,p.Asn202Thr,0.890774115,2.02e-28,3.71e-55,-0.890774115 +urn:mavedb:00000041-a-1#1366,NA,NA,p.Asn202Ter,1.50960166,0.000106779,2.2e-09,-1.50960166 +urn:mavedb:00000041-a-1#1367,NA,NA,p.Asn202Ser,1.207065489,6.08e-09,2.7500000000000003e-17,-1.207065489 +urn:mavedb:00000041-a-1#1368,NA,NA,p.Asn202Pro,0.8029725409999999,2.46e-12,7.93e-24,-0.8029725409999999 +urn:mavedb:00000041-a-1#1369,NA,NA,p.Asn202Phe,1.325968973,5.45e-11,3.24e-21,-1.325968973 +urn:mavedb:00000041-a-1#1372,NA,NA,p.Asn202Leu,0.997180355,5.47e-16,6.809999999999999e-31,-0.997180355 +urn:mavedb:00000041-a-1#1373,NA,NA,p.Asn202Ile,0.496911683,3.4800000000000003e-54,1.1799999999999996e-105,-0.496911683 +urn:mavedb:00000041-a-1#1374,NA,NA,p.Asn202His,0.482406416,0.243590405,4.1600000000000007e-17,-0.482406416 +urn:mavedb:00000041-a-1#1375,NA,NA,p.Asn202Gly,0.981930634,5.18e-20,9.869999999999999e-39,-0.981930634 +urn:mavedb:00000041-a-1#1376,NA,NA,p.Asn202Glu,1.546517939,1.92e-05,1e-10,-1.546517939 +urn:mavedb:00000041-a-1#1377,NA,NA,p.Asn202Gln,0.7828680720000001,1.53e-21,1.0199999999999999e-41,-0.7828680720000001 +urn:mavedb:00000041-a-1#1378,NA,NA,p.Asn202Cys,1.308885283,5.14e-05,5.74e-10,-1.308885283 +urn:mavedb:00000041-a-1#1379,NA,NA,p.Asn202Asp,1.7656940230000002,0.004463616,5.02e-07,-1.7656940230000002 +urn:mavedb:00000041-a-1#1380,NA,NA,p.Asn202Arg,1.170782607,2.8100000000000003e-15,1.65e-29,-1.170782607 +urn:mavedb:00000041-a-1#1381,NA,NA,p.Asn202Ala,1.063258539,3.54e-16,2.9199999999999998e-31,-1.063258539 +urn:mavedb:00000041-a-1#1382,NA,NA,p.Asn148Ter,1.6591108369999998,1.15e-11,1.61e-22,-1.6591108369999998 +urn:mavedb:00000041-a-1#1383,NA,NA,p.Asn148Pro,1.531914183,3.98e-10,1.49e-19,-1.531914183 +urn:mavedb:00000041-a-1#1384,NA,NA,p.Asn148Met,0.70336924,2.6e-11,7.299999999999998e-22,-0.70336924 +urn:mavedb:00000041-a-1#1385,NA,NA,p.Asn148Lys,0.874831864,4.220000000000001e-11,1.9600000000000007e-21,-0.874831864 +urn:mavedb:00000041-a-1#1386,NA,NA,p.Asn148Leu,0.883496697,8.32e-38,1.54e-73,-0.883496697 +urn:mavedb:00000041-a-1#1387,NA,NA,p.Asn148Ile,1.152408366,2.7300000000000003e-12,9.93e-24,-1.152408366 +urn:mavedb:00000041-a-1#1388,NA,NA,p.Asn148Cys,0.493660091,0.025022166,3.45e-05,-0.493660091 +urn:mavedb:00000041-a-1#1389,NA,NA,p.Asn148Arg,0.7713521940000001,1.65e-33,4.06e-65,-0.7713521940000001 +urn:mavedb:00000041-a-1#1390,NA,NA,p.Asn148Ala,0.89987412,6.59e-10,3.9199999999999997e-19,-0.89987412 +urn:mavedb:00000041-a-1#1391,NA,NA,p.Asn125Val,1.603436611,3.43e-16,2.7799999999999998e-31,-1.603436611 +urn:mavedb:00000041-a-1#1392,NA,NA,p.Asn125Tyr,1.584994718,1.29e-05,4.85e-11,-1.584994718 +urn:mavedb:00000041-a-1#1393,NA,NA,p.Asn125Ser,1.772539114,0.001910217,2.09e-07,-1.772539114 +urn:mavedb:00000041-a-1#1394,NA,NA,p.Asn125Pro,1.593820634,0.001396611,1.49e-07,-1.593820634 +urn:mavedb:00000041-a-1#1395,NA,NA,p.Asn125Phe,1.761168137,0.4299815,1.33e-08,-1.761168137 +urn:mavedb:00000041-a-1#1396,NA,NA,p.Asn125Met,1.616528245,2.4e-08,3.66e-16,-1.616528245 +urn:mavedb:00000041-a-1#1397,NA,NA,p.Asn125Leu,1.61829063,2.2e-05,1.29e-10,-1.61829063 +urn:mavedb:00000041-a-1#1398,NA,NA,p.Asn125Ile,1.523601777,2.53e-05,1.65e-10,-1.523601777 +urn:mavedb:00000041-a-1#1399,NA,NA,p.Asn125His,1.9669932,2.6e-21,2.9299999999999997e-41,-1.9669932 +urn:mavedb:00000041-a-1#1400,NA,NA,p.Asn125Gly,1.8006081980000002,0.352859608,5.83e-09,-1.8006081980000002 +urn:mavedb:00000041-a-1#1401,NA,NA,p.Asn125Gln,1.391460199,2.54e-16,1.55e-31,-1.391460199 +urn:mavedb:00000041-a-1#1403,NA,NA,p.Asn125Asp,1.680941,0.4897628020000001,1.62e-11,-1.680941 +urn:mavedb:00000041-a-1#1404,NA,NA,p.Asn125Arg,1.786398423,0.539667327,4.94e-09,-1.786398423 +urn:mavedb:00000041-a-1#1405,NA,NA,p.Asn125Ala,1.583857225,5.480000000000001e-12,3.91e-23,-1.583857225 +urn:mavedb:00000041-a-1#1406,NA,NA,p.Asn115Val,0.854199252,1.040102753,2.22e-16,-0.854199252 +urn:mavedb:00000041-a-1#1407,NA,NA,p.Asn115Ter,1.5414087230000002,5.629999999999999e-13,4.82e-25,-1.5414087230000002 +urn:mavedb:00000041-a-1#1408,NA,NA,p.Asn115Ile,0.6926778929999999,8.31e-20,2.46e-38,-0.6926778929999999 +urn:mavedb:00000041-a-1#1409,NA,NA,p.Asn115Glu,0.903909485,9.82e-26,6.71e-50,-0.903909485 +urn:mavedb:00000041-a-1#1410,NA,NA,p.Asn115Asp,0.959415485,1.3800000000000002e-09,1.6e-18,-0.959415485 +urn:mavedb:00000041-a-1#1411,NA,NA,p.Asn115Ala,0.7075015029999999,0.5308723439999999,0.0,-0.7075015029999999 +urn:mavedb:00000041-a-1#1412,NA,NA,p.Asn21Ter,1.5878241219999998,6.29e-11,4.31e-21,-1.5878241219999998 +urn:mavedb:00000041-a-1#1413,NA,NA,p.Asn21Lys,0.466800783,0.288181047,1.39e-17,-0.466800783 +urn:mavedb:00000041-a-1#1414,NA,NA,p.Arg240Val,1.5897028,2.33e-06,2.08e-12,-1.5897028 +urn:mavedb:00000041-a-1#1415,NA,NA,p.Arg240Tyr,1.6477999559999998,0.264473711,0.000110336,-1.6477999559999998 +urn:mavedb:00000041-a-1#1416,NA,NA,p.Arg240Trp,1.4591402480000002,7.589999999999999e-18,1.6899999999999998e-34,-1.4591402480000002 +urn:mavedb:00000041-a-1#1417,NA,NA,p.Arg240Thr,1.5908540480000002,1.69e-08,1.94e-16,-1.5908540480000002 +urn:mavedb:00000041-a-1#1418,NA,NA,p.Arg240Ter,1.452863991,7.03e-13,7.419999999999998e-25,-1.452863991 +urn:mavedb:00000041-a-1#1419,NA,NA,p.Arg240Ser,1.554135484,3.28e-11,1.2300000000000002e-21,-1.554135484 +urn:mavedb:00000041-a-1#1420,NA,NA,p.Arg240Pro,1.587071721,9.25e-09,6.18e-17,-1.587071721 +urn:mavedb:00000041-a-1#1421,NA,NA,p.Arg240Phe,1.722014498,0.269077719,0.000323785,-1.722014498 +urn:mavedb:00000041-a-1#1422,NA,NA,p.Arg240Met,1.6285559580000002,1.01e-08,7.22e-17,-1.6285559580000002 +urn:mavedb:00000041-a-1#1423,NA,NA,p.Arg240Lys,1.611260485,5.54e-06,1.04e-11,-1.611260485 +urn:mavedb:00000041-a-1#1424,NA,NA,p.Arg240Leu,1.567043559,8.19e-16,1.5e-30,-1.567043559 +urn:mavedb:00000041-a-1#1425,NA,NA,p.Arg240Ile,1.51228924,1.86e-07,1.84e-14,-1.51228924 +urn:mavedb:00000041-a-1#1426,NA,NA,p.Arg240His,1.585959926,4.52e-08,1.25e-15,-1.585959926 +urn:mavedb:00000041-a-1#1427,NA,NA,p.Arg240Gly,1.6166967630000002,2.7600000000000007e-05,1.95e-10,-1.6166967630000002 +urn:mavedb:00000041-a-1#1428,NA,NA,p.Arg240Glu,1.600229056,1.04e-10,1.1299999999999999e-20,-1.600229056 +urn:mavedb:00000041-a-1#1429,NA,NA,p.Arg240Gln,1.718585597,5.92e-12,4.51e-23,-1.718585597 +urn:mavedb:00000041-a-1#1430,NA,NA,p.Arg240Cys,1.554288866,0.002774294,3.34e-07,-1.554288866 +urn:mavedb:00000041-a-1#1431,NA,NA,p.Arg240Asp,1.437106256,3.5100000000000002e-15,2.57e-29,-1.437106256 +urn:mavedb:00000041-a-1#1432,NA,NA,p.Arg240Asn,1.631159765,1.25e-07,8.559999999999999e-15,-1.631159765 +urn:mavedb:00000041-a-1#1433,NA,NA,p.Arg240Ala,1.587450152,9.01e-10,7.21e-19,-1.587450152 +urn:mavedb:00000041-a-1#1434,NA,NA,p.Arg234Ter,1.6595728440000002,9.45e-11,9.46e-21,-1.6595728440000002 +urn:mavedb:00000041-a-1#1435,NA,NA,p.Arg234Pro,0.8100539920000001,3.6700000000000005e-53,1.2499999999999992e-103,-0.8100539920000001 +urn:mavedb:00000041-a-1#1436,NA,NA,p.Arg214Trp,0.88755668,2.03e-89,1.0199999999999992e-174,-0.88755668 +urn:mavedb:00000041-a-1#1437,NA,NA,p.Arg214Ter,1.588086749,1.33e-13,2.9300000000000003e-26,-1.588086749 +urn:mavedb:00000041-a-1#1438,NA,NA,p.Arg214Ser,0.82804177,2.8e-27,6.26e-53,-0.82804177 +urn:mavedb:00000041-a-1#1439,NA,NA,p.Arg214Pro,1.488462214,3.61e-12,1.74e-23,-1.488462214 +urn:mavedb:00000041-a-1#1440,NA,NA,p.Arg214Gly,1.429780688,7.83e-15,1.22e-28,-1.429780688 +urn:mavedb:00000041-a-1#1441,NA,NA,p.Arg214Glu,1.188601005,1.1299999999999999e-20,5.1099999999999995e-40,-1.188601005 +urn:mavedb:00000041-a-1#1442,NA,NA,p.Arg214Asp,1.563211712,1.99e-08,2.63e-16,-1.563211712 +urn:mavedb:00000041-a-1#1443,NA,NA,p.Arg214Ala,0.8493144909999999,4.6399999999999995e-28,1.88e-54,-0.8493144909999999 +urn:mavedb:00000041-a-1#1444,NA,NA,p.Arg211Ter,1.4890573319999998,3.64e-09,1.0400000000000002e-17,-1.4890573319999998 +urn:mavedb:00000041-a-1#1445,NA,NA,p.Arg211Pro,1.145401156,6.9e-17,1.2199999999999999e-32,-1.145401156 +urn:mavedb:00000041-a-1#1446,NA,NA,p.Arg211Asn,1.125249171,0.554727877,0.0,-1.125249171 +urn:mavedb:00000041-a-1#1447,NA,NA,p.Arg203Ter,1.380309368,0.000611585,4.07e-08,-1.380309368 +urn:mavedb:00000041-a-1#1448,NA,NA,p.Arg203Ile,0.5666849070000001,0.619774185,0.0,-0.5666849070000001 +urn:mavedb:00000041-a-1#1449,NA,NA,p.Arg203Glu,1.253391624,3.78e-09,1.09e-17,-1.253391624 +urn:mavedb:00000041-a-1#1450,NA,NA,p.Arg203Asp,0.958234762,2.3699999999999997e-30,6.13e-59,-0.958234762 +urn:mavedb:00000041-a-1#1451,NA,NA,p.Arg194Ter,1.677718103,9.45e-07,3.91e-13,-1.677718103 +urn:mavedb:00000041-a-1#1452,NA,NA,p.Arg194Pro,1.718054435,1.0800000000000003e-05,3.45e-11,-1.718054435 +urn:mavedb:00000041-a-1#1453,NA,NA,p.Arg194Met,0.581773117,0.262617227,7.88e-12,-0.581773117 +urn:mavedb:00000041-a-1#1454,NA,NA,p.Arg194Cys,0.467164754,8.02e-12,7.590000000000002e-23,-0.467164754 +urn:mavedb:00000041-a-1#1455,NA,NA,p.Arg194Asp,1.36634269,9.259999999999999e-20,3.13e-38,-1.36634269 +urn:mavedb:00000041-a-1#1456,NA,NA,p.Arg172Tyr,0.632453023,1.91e-37,7.929999999999998e-73,-0.632453023 +urn:mavedb:00000041-a-1#1457,NA,NA,p.Arg172Trp,0.651276309,9.25e-40,2.3399999999999997e-77,-0.651276309 +urn:mavedb:00000041-a-1#1458,NA,NA,p.Arg172Ter,1.649876198,2.1e-11,5.24e-22,-1.649876198 +urn:mavedb:00000041-a-1#1459,NA,NA,p.Arg172Pro,0.726792663,1.16e-15,2.9099999999999998e-30,-0.726792663 +urn:mavedb:00000041-a-1#1460,NA,NA,p.Arg172Phe,0.902962809,6.299999999999998e-79,3.8099999999999973e-154,-0.902962809 +urn:mavedb:00000041-a-1#1461,NA,NA,p.Arg172Met,0.887410122,2.91e-65,2.3399999999999986e-127,-0.887410122 +urn:mavedb:00000041-a-1#1462,NA,NA,p.Arg172Leu,1.104295989,1.2e-18,4.55e-36,-1.104295989 +urn:mavedb:00000041-a-1#1463,NA,NA,p.Arg172Glu,1.227609566,1.61e-16,6.349999999999999e-32,-1.227609566 +urn:mavedb:00000041-a-1#1464,NA,NA,p.Arg172Gln,0.739844267,8.89e-42,2.5599999999999996e-81,-0.739844267 +urn:mavedb:00000041-a-1#1465,NA,NA,p.Arg172Asp,1.601346453,0.000346037,1.58e-08,-1.601346453 +urn:mavedb:00000041-a-1#1466,NA,NA,p.Arg172Asn,1.100674315,9.12e-44,3.259999999999999e-85,-1.100674315 +urn:mavedb:00000041-a-1#1467,NA,NA,p.Arg172Ala,0.7088461840000001,1.83e-15,6.96e-30,-0.7088461840000001 +urn:mavedb:00000041-a-1#1468,NA,NA,p.Arg153Val,0.8192062370000001,4.359999999999999e-48,1.1099999999999994e-93,-0.8192062370000001 +urn:mavedb:00000041-a-1#1469,NA,NA,p.Arg153Tyr,0.90574953,6.139999999999998e-55,4.109999999999998e-107,-0.90574953 +urn:mavedb:00000041-a-1#1470,NA,NA,p.Arg153Trp,0.8124307540000001,1.1999999999999999e-28,1.32e-55,-0.8124307540000001 +urn:mavedb:00000041-a-1#1471,NA,NA,p.Arg153Ter,1.663449451,0.023908285,2.13e-05,-1.663449451 +urn:mavedb:00000041-a-1#1472,NA,NA,p.Arg153Phe,1.111408807,2.919999999999999e-72,4.489999999999998e-141,-1.111408807 +urn:mavedb:00000041-a-1#1473,NA,NA,p.Arg153Met,0.777244651,4.45e-51,1.4999999999999992e-99,-0.777244651 +urn:mavedb:00000041-a-1#1474,NA,NA,p.Arg153Leu,0.906785188,1.72e-48,1.7799999999999992e-94,-0.906785188 +urn:mavedb:00000041-a-1#1475,NA,NA,p.Arg153Ile,1.022169145,1.4e-47,1.0799999999999997e-92,-1.022169145 +urn:mavedb:00000041-a-1#1476,NA,NA,p.Arg153Glu,0.478966556,1.01e-30,1.1399999999999996e-59,-0.478966556 +urn:mavedb:00000041-a-1#1477,NA,NA,p.Arg153Gln,0.5114322370000001,2.32e-05,1.21e-10,-0.5114322370000001 +urn:mavedb:00000041-a-1#1478,NA,NA,p.Arg153Asp,0.6931674640000001,6.77e-25,2.87e-48,-0.6931674640000001 +urn:mavedb:00000041-a-1#1479,NA,NA,p.Arg153Ala,0.570675975,7.87e-30,6.219999999999999e-58,-0.570675975 +urn:mavedb:00000041-a-1#1480,NA,NA,p.Arg143Val,1.254735855,3.81e-26,1.0499999999999998e-50,-1.254735855 +urn:mavedb:00000041-a-1#1481,NA,NA,p.Arg143Tyr,1.5056525040000002,5.12e-11,2.91e-21,-1.5056525040000002 +urn:mavedb:00000041-a-1#1482,NA,NA,p.Arg143Trp,1.571657409,9.3e-15,1.6999999999999996e-28,-1.571657409 +urn:mavedb:00000041-a-1#1483,NA,NA,p.Arg143Thr,1.015541835,5.4399999999999985e-47,1.5799999999999992e-91,-1.015541835 +urn:mavedb:00000041-a-1#1484,NA,NA,p.Arg143Ter,1.617167761,1.55e-09,2.02e-18,-1.617167761 +urn:mavedb:00000041-a-1#1485,NA,NA,p.Arg143Pro,1.6376936219999998,1.87e-05,9.53e-11,-1.6376936219999998 +urn:mavedb:00000041-a-1#1486,NA,NA,p.Arg143Phe,1.381415906,9.28e-13,1.26e-24,-1.381415906 +urn:mavedb:00000041-a-1#1487,NA,NA,p.Arg143Leu,1.312008844,4.49e-10,1.87e-19,-1.312008844 +urn:mavedb:00000041-a-1#1488,NA,NA,p.Arg143His,1.780599716,0.268206484,1.42e-05,-1.780599716 +urn:mavedb:00000041-a-1#1489,NA,NA,p.Arg143Gly,1.53044378,8.130000000000001e-08,3.8299999999999995e-15,-1.53044378 +urn:mavedb:00000041-a-1#1490,NA,NA,p.Arg143Glu,1.525404768,4.1900000000000005e-12,2.2999999999999998e-23,-1.525404768 +urn:mavedb:00000041-a-1#1491,NA,NA,p.Arg143Gln,1.252943383,7.07e-06,1.64e-11,-1.252943383 +urn:mavedb:00000041-a-1#1492,NA,NA,p.Arg143Cys,1.5294887030000002,6.929999999999999e-13,7.090000000000001e-25,-1.5294887030000002 +urn:mavedb:00000041-a-1#1493,NA,NA,p.Arg143Asp,1.504452464,1.69e-07,1.51e-14,-1.504452464 +urn:mavedb:00000041-a-1#1494,NA,NA,p.Arg143Asn,1.429842262,7.55e-06,1.85e-11,-1.429842262 +urn:mavedb:00000041-a-1#1495,NA,NA,p.Arg143Ala,1.545402765,5.18e-07,1.25e-13,-1.545402765 +urn:mavedb:00000041-a-1#1496,NA,NA,p.Arg122Val,1.607396576,0.269491175,8.06e-05,-1.607396576 +urn:mavedb:00000041-a-1#1497,NA,NA,p.Arg122Tyr,1.532677651,7.259999999999998e-07,2.35e-13,-1.532677651 +urn:mavedb:00000041-a-1#1498,NA,NA,p.Arg122Thr,1.502866529,0.00017485099999999998,5.11e-09,-1.502866529 +urn:mavedb:00000041-a-1#1499,NA,NA,p.Arg122Ser,1.571482272,7.09e-07,2.23e-13,-1.571482272 +urn:mavedb:00000041-a-1#1500,NA,NA,p.Arg122Pro,1.589969979,3.23e-11,1.19e-21,-1.589969979 +urn:mavedb:00000041-a-1#1501,NA,NA,p.Arg122Phe,1.3968963909999998,1.59e-20,1.0099999999999997e-39,-1.3968963909999998 +urn:mavedb:00000041-a-1#1502,NA,NA,p.His118Gly,1.663885167,5.34e-05,6.189999999999999e-10,-1.663885167 +urn:mavedb:00000041-a-1#1503,NA,NA,p.His118Gln,1.106908837,6.24e-23,2.0299999999999998e-44,-1.106908837 +urn:mavedb:00000041-a-1#1504,NA,NA,p.His118Cys,1.522984755,3.85e-08,9.279999999999999e-16,-1.522984755 +urn:mavedb:00000041-a-1#1505,NA,NA,p.His118Arg,1.476809686,1.37e-16,4.66e-32,-1.476809686 +urn:mavedb:00000041-a-1#1506,NA,NA,p.His118Ala,1.566643617,5.46e-11,3.289999999999999e-21,-1.566643617 +urn:mavedb:00000041-a-1#1507,NA,NA,p.His53Ile,1.349626981,2.96e-07,4.28e-14,-1.349626981 +urn:mavedb:00000041-a-1#1508,NA,NA,p.Gly212Val,1.505068233,7.33e-12,6.870000000000001e-23,-1.505068233 +urn:mavedb:00000041-a-1#1509,NA,NA,p.Gly212Tyr,0.7943786629999999,1.05e-24,6.7e-48,-0.7943786629999999 +urn:mavedb:00000041-a-1#1510,NA,NA,p.Gly212Trp,1.095610128,1.0499999999999998e-43,4.2899999999999995e-85,-1.095610128 +urn:mavedb:00000041-a-1#1511,NA,NA,p.Gly212Thr,1.180052738,7.05e-19,1.62e-36,-1.180052738 +urn:mavedb:00000041-a-1#1512,NA,NA,p.Gly212Ter,1.60427638,1.6e-11,3.1e-22,-1.60427638 +urn:mavedb:00000041-a-1#1513,NA,NA,p.Gly212Ser,0.462541262,5.33e-19,9.16e-37,-0.462541262 +urn:mavedb:00000041-a-1#1514,NA,NA,p.Gly212Pro,1.524492067,1.9e-08,2.42e-16,-1.524492067 +urn:mavedb:00000041-a-1#1515,NA,NA,p.Gly212Phe,0.989627639,9.919999999999998e-49,6.089999999999997e-95,-0.989627639 +urn:mavedb:00000041-a-1#1516,NA,NA,p.Gly212Met,1.101951144,0.198041038,0.000831795,-1.101951144 +urn:mavedb:00000041-a-1#1517,NA,NA,p.Gly212Lys,0.977771957,1.52e-27,1.91e-53,-0.977771957 +urn:mavedb:00000041-a-1#1518,NA,NA,p.Gly212Leu,0.951057204,3.88e-30,1.6199999999999996e-58,-0.951057204 +urn:mavedb:00000041-a-1#1519,NA,NA,p.Gly212Ile,1.494262142,1.45e-09,1.7700000000000002e-18,-1.494262142 +urn:mavedb:00000041-a-1#1520,NA,NA,p.Gly212His,0.660849053,9.509999999999999e-39,2.1999999999999998e-75,-0.660849053 +urn:mavedb:00000041-a-1#1521,NA,NA,p.Gly212Glu,0.687995197,7.39e-14,9.03e-27,-0.687995197 +urn:mavedb:00000041-a-1#1522,NA,NA,p.Gly212Gln,0.998978797,8.58e-27,5.5999999999999984e-52,-0.998978797 +urn:mavedb:00000041-a-1#1523,NA,NA,p.Gly212Cys,0.790718457,1.86e-53,3.2799999999999984e-104,-0.790718457 +urn:mavedb:00000041-a-1#1524,NA,NA,p.Gly212Arg,0.8741602740000001,8.710000000000001e-28,6.46e-54,-0.8741602740000001 +urn:mavedb:00000041-a-1#1525,NA,NA,p.Gly212Ala,0.673697832,7.09e-36,9.339999999999999e-70,-0.673697832 +urn:mavedb:00000041-a-1#1526,NA,NA,p.Gly199Val,0.580134709,7.16e-19,1.57e-36,-0.580134709 +urn:mavedb:00000041-a-1#1527,NA,NA,p.Gly193Ser,0.6759585090000001,0.141624787,3.94e-08,-0.6759585090000001 +urn:mavedb:00000041-a-1#1528,NA,NA,p.Gly183Lys,1.272900615,5.479999999999998e-53,2.7699999999999997e-103,-1.272900615 +urn:mavedb:00000041-a-1#1529,NA,NA,p.Gly183Ile,1.663654626,2.69e-05,1.84e-10,-1.663654626 +urn:mavedb:00000041-a-1#1530,NA,NA,p.Gly183Asn,1.622715732,1.11e-05,3.74e-11,-1.622715732 +urn:mavedb:00000041-a-1#1531,NA,NA,p.Gly171Val,1.103790951,1.8899999999999998e-46,1.81e-90,-1.103790951 +urn:mavedb:00000041-a-1#1532,NA,NA,p.Gly171Thr,1.156085861,1.87e-35,6.289999999999997e-69,-1.156085861 +urn:mavedb:00000041-a-1#1533,NA,NA,p.Gly171Ter,1.619955859,0.000263931,1.04e-08,-1.619955859 +urn:mavedb:00000041-a-1#1534,NA,NA,p.Gly171Ser,0.8831723570000001,2.78e-35,1.37e-68,-0.8831723570000001 +urn:mavedb:00000041-a-1#1535,NA,NA,p.Gly171Pro,1.637138652,1.94e-10,3.77e-20,-1.637138652 +urn:mavedb:00000041-a-1#1536,NA,NA,p.Gly171Lys,1.150200078,5.99e-12,4.5799999999999995e-23,-1.150200078 +urn:mavedb:00000041-a-1#1537,NA,NA,p.Gly171Ile,1.195480238,5.3e-21,1.1699999999999998e-40,-1.195480238 +urn:mavedb:00000041-a-1#1538,NA,NA,p.Gly171Glu,1.638407893,4.94e-10,2.2399999999999997e-19,-1.638407893 +urn:mavedb:00000041-a-1#1539,NA,NA,p.Gly171Gln,0.817832085,1.92e-24,2.2199999999999996e-47,-0.817832085 +urn:mavedb:00000041-a-1#1540,NA,NA,p.Gly171Cys,0.569029015,1.61e-17,6.9199999999999995e-34,-0.569029015 +urn:mavedb:00000041-a-1#1541,NA,NA,p.Gly171Asp,1.489377295,3.48e-07,5.91e-14,-1.489377295 +urn:mavedb:00000041-a-1#1542,NA,NA,p.Gly171Asn,1.018322886,8.320000000000001e-27,5.35e-52,-1.018322886 +urn:mavedb:00000041-a-1#1543,NA,NA,p.Gly171Ala,0.738325769,2.5199999999999997e-30,6.88e-59,-0.738325769 +urn:mavedb:00000041-a-1#1544,NA,NA,p.Gly155Val,1.345706789,4.38e-13,2.93e-25,-1.345706789 +urn:mavedb:00000041-a-1#1545,NA,NA,p.Gly155Tyr,0.82714338,9.15e-32,1.0599999999999998e-61,-0.82714338 +urn:mavedb:00000041-a-1#1546,NA,NA,p.Gly155Thr,1.035164891,1.63e-21,1.17e-41,-1.035164891 +urn:mavedb:00000041-a-1#1547,NA,NA,p.Gly155Ser,0.897203077,6.98e-38,1.0899999999999995e-73,-0.897203077 +urn:mavedb:00000041-a-1#1548,NA,NA,p.Gly155Pro,0.755671676,0.0,0.0,-0.755671676 +urn:mavedb:00000041-a-1#1549,NA,NA,p.Gly155Met,1.421996349,1.74e-14,5.67e-28,-1.421996349 +urn:mavedb:00000041-a-1#1550,NA,NA,p.Gly155Lys,1.363877423,1.92e-16,8.88e-32,-1.363877423 +urn:mavedb:00000041-a-1#1551,NA,NA,p.Gly155Leu,1.388174337,5.43e-11,3.2500000000000003e-21,-1.388174337 +urn:mavedb:00000041-a-1#1552,NA,NA,p.Gly155Ile,1.3266607190000002,4.92e-15,4.92e-29,-1.3266607190000002 +urn:mavedb:00000041-a-1#1553,NA,NA,p.Gly155Glu,0.97300785,7.499999999999998e-41,1.689999999999999e-79,-0.97300785 +urn:mavedb:00000041-a-1#1554,NA,NA,p.Gly155Gln,1.098539448,1.0199999999999999e-78,9.679999999999993e-154,-1.098539448 +urn:mavedb:00000041-a-1#1555,NA,NA,p.Gly155Asn,0.594007391,2.06e-32,5.549999999999999e-63,-0.594007391 +urn:mavedb:00000041-a-1#1556,NA,NA,p.Gly155Arg,1.220747061,6.78e-17,1.1799999999999997e-32,-1.220747061 +urn:mavedb:00000041-a-1#1557,NA,NA,p.Gly155Ala,1.128432382,7.5e-17,1.4399999999999999e-32,-1.128432382 +urn:mavedb:00000041-a-1#1558,NA,NA,p.Gly140Val,1.525594886,4.57e-12,2.75e-23,-1.525594886 +urn:mavedb:00000041-a-1#1559,NA,NA,p.Gly140Trp,1.528431816,0.109583107,0.0008772060000000001,-1.528431816 +urn:mavedb:00000041-a-1#1560,NA,NA,p.Gly140Thr,1.611804443,2.18e-06,1.81e-12,-1.611804443 +urn:mavedb:00000041-a-1#1561,NA,NA,p.Gly140Ter,1.735641025,0.145469996,0.001451882,-1.735641025 +urn:mavedb:00000041-a-1#1563,NA,NA,p.Gly140Pro,1.5916215180000002,0.000139546,3.429999999999999e-09,-1.5916215180000002 +urn:mavedb:00000041-a-1#1564,NA,NA,p.Gly140Phe,1.600045668,8.2e-07,2.94e-13,-1.600045668 +urn:mavedb:00000041-a-1#1565,NA,NA,p.Gly140Met,1.6483269180000002,6.620000000000001e-07,1.97e-13,-1.6483269180000002 +urn:mavedb:00000041-a-1#1566,NA,NA,p.Gly140Lys,1.896500684,0.0017749329999999996,2.11e-07,-1.896500684 +urn:mavedb:00000041-a-1#1567,NA,NA,p.Gly140Leu,1.64066482,4.77e-08,1.3900000000000001e-15,-1.64066482 +urn:mavedb:00000041-a-1#1568,NA,NA,p.Gly140Ile,1.829795151,3.4e-08,7.320000000000002e-16,-1.829795151 +urn:mavedb:00000041-a-1#1569,NA,NA,p.Gly140His,1.524250462,8.46e-10,6.35e-19,-1.524250462 +urn:mavedb:00000041-a-1#1570,NA,NA,p.Gly140Glu,1.556459761,6.35e-21,1.67e-40,-1.556459761 +urn:mavedb:00000041-a-1#1571,NA,NA,p.Gly140Gln,1.6027115369999998,7.59e-08,3.3700000000000003e-15,-1.6027115369999998 +urn:mavedb:00000041-a-1#1572,NA,NA,p.Gly140Asp,1.552865178,2.02e-11,4.83e-22,-1.552865178 +urn:mavedb:00000041-a-1#1573,NA,NA,p.Gly140Asn,1.543935964,1.19e-05,4.05e-11,-1.543935964 +urn:mavedb:00000041-a-1#1574,NA,NA,p.Gly140Arg,1.552798717,1.9e-09,3.02e-18,-1.552798717 +urn:mavedb:00000041-a-1#1575,NA,NA,p.Gly140Ala,1.616604248,2.0600000000000006e-05,1.13e-10,-1.616604248 +urn:mavedb:00000041-a-1#1576,NA,NA,p.Gly129Val,0.903032443,2.53e-05,1.52e-10,-0.903032443 +urn:mavedb:00000041-a-1#1577,NA,NA,p.Gly129Tyr,0.816020333,1.6999999999999999e-19,9.95e-38,-0.816020333 +urn:mavedb:00000041-a-1#1578,NA,NA,p.Gly129Trp,1.115009437,2.9100000000000003e-10,8.14e-20,-1.115009437 +urn:mavedb:00000041-a-1#1579,NA,NA,p.Gly129Ter,1.593778204,2.1e-08,2.9300000000000003e-16,-1.593778204 +urn:mavedb:00000041-a-1#1580,NA,NA,p.Gly129Pro,0.906507817,0.496189891,1.56e-09,-0.906507817 +urn:mavedb:00000041-a-1#1581,NA,NA,p.Gly129Phe,1.089430755,2.86e-23,4.33e-45,-1.089430755 +urn:mavedb:00000041-a-1#1582,NA,NA,p.Gly129Leu,0.519039255,3.5400000000000004e-18,3.76e-35,-0.519039255 +urn:mavedb:00000041-a-1#1583,NA,NA,p.Gly129Ile,0.814899954,1.63e-30,2.96e-59,-0.814899954 +urn:mavedb:00000041-a-1#1584,NA,NA,p.Gly107Val,1.463307993,8.92e-06,2.45e-11,-1.463307993 +urn:mavedb:00000041-a-1#1585,NA,NA,p.Arg122Lys,1.304469053,5.589999999999999e-09,2.34e-17,-1.304469053 +urn:mavedb:00000041-a-1#1586,NA,NA,p.Arg122Leu,1.63877344,2.48e-09,4.95e-18,-1.63877344 +urn:mavedb:00000041-a-1#1587,NA,NA,p.Arg122Ile,1.639698651,2.59e-07,3.35e-14,-1.639698651 +urn:mavedb:00000041-a-1#1588,NA,NA,p.Arg122His,1.511786085,6.459999999999999e-07,1.92e-13,-1.511786085 +urn:mavedb:00000041-a-1#1589,NA,NA,p.Arg122Gly,1.547641074,1.23e-18,4.86e-36,-1.547641074 +urn:mavedb:00000041-a-1#1590,NA,NA,p.Arg122Glu,1.460301081,7.89e-12,7.899999999999998e-23,-1.460301081 +urn:mavedb:00000041-a-1#1591,NA,NA,p.Arg122Gln,1.880901955,0.000234111,7.77e-09,-1.880901955 +urn:mavedb:00000041-a-1#1592,NA,NA,p.Arg122Cys,1.477636372,6.05e-10,3.3399999999999997e-19,-1.477636372 +urn:mavedb:00000041-a-1#1593,NA,NA,p.Arg122Asp,1.575992162,9.89e-13,1.43e-24,-1.575992162 +urn:mavedb:00000041-a-1#1594,NA,NA,p.Arg122Asn,1.5085041280000002,6.929999999999999e-12,6.110000000000001e-23,-1.5085041280000002 +urn:mavedb:00000041-a-1#1595,NA,NA,p.Arg122Ala,1.510186971,6.570000000000001e-12,5.53e-23,-1.510186971 +urn:mavedb:00000041-a-1#1596,NA,NA,p.Arg119Tyr,1.552100263,6.949999999999999e-11,5.190000000000001e-21,-1.552100263 +urn:mavedb:00000041-a-1#1597,NA,NA,p.Arg119Thr,1.541849959,5.49e-15,6.12e-29,-1.541849959 +urn:mavedb:00000041-a-1#1598,NA,NA,p.Arg119Ser,1.481842665,2.21e-10,4.82e-20,-1.481842665 +urn:mavedb:00000041-a-1#1599,NA,NA,p.Arg119Pro,1.483734649,3.42e-08,7.440000000000002e-16,-1.483734649 +urn:mavedb:00000041-a-1#1600,NA,NA,p.Arg119Phe,1.450174255,3.5200000000000005e-18,3.82e-35,-1.450174255 +urn:mavedb:00000041-a-1#1601,NA,NA,p.Arg119Leu,1.51130375,7.71e-09,4.36e-17,-1.51130375 +urn:mavedb:00000041-a-1#1602,NA,NA,p.Arg119Ile,0.651445885,6.55e-08,2.43e-15,-0.651445885 +urn:mavedb:00000041-a-1#1603,NA,NA,p.Arg119His,1.545293729,0.002907553,3.55e-07,-1.545293729 +urn:mavedb:00000041-a-1#1604,NA,NA,p.Arg119Gly,1.770053668,1.86e-11,4.12e-22,-1.770053668 +urn:mavedb:00000041-a-1#1605,NA,NA,p.Arg119Gln,1.5796613030000002,6.43e-27,3.259999999999998e-52,-1.5796613030000002 +urn:mavedb:00000041-a-1#1606,NA,NA,p.Arg119Asp,1.651676681,1.97e-05,1.07e-10,-1.651676681 +urn:mavedb:00000041-a-1#1607,NA,NA,p.Arg119Asn,1.169262798,5.32e-14,4.9e-27,-1.169262798 +urn:mavedb:00000041-a-1#1608,NA,NA,p.Arg113Pro,1.472081063,0.000996315,8.39e-08,-1.472081063 +urn:mavedb:00000041-a-1#1609,NA,NA,p.Arg93Val,0.6597083020000001,3.96e-24,9.15e-47,-0.6597083020000001 +urn:mavedb:00000041-a-1#1610,NA,NA,p.Arg93Thr,0.8447403170000001,3.6000000000000007e-06,4.450000000000001e-12,-0.8447403170000001 +urn:mavedb:00000041-a-1#1611,NA,NA,p.Ala152Gly,1.154671398,1.5199999999999998e-25,1.5599999999999997e-49,-1.154671398 +urn:mavedb:00000041-a-1#1612,NA,NA,p.Ala152Glu,1.4407351330000002,1.42e-15,4.4e-30,-1.4407351330000002 +urn:mavedb:00000041-a-1#1613,NA,NA,p.Ala152Gln,1.17713167,1.72e-29,2.999999999999999e-57,-1.17713167 +urn:mavedb:00000041-a-1#1614,NA,NA,p.Ala152Asp,1.443087174,1.25e-10,1.6100000000000002e-20,-1.443087174 +urn:mavedb:00000041-a-1#1615,NA,NA,p.Ala152Asn,1.383495092,9.17e-15,1.6299999999999993e-28,-1.383495092 +urn:mavedb:00000041-a-1#1616,NA,NA,p.Ala152Arg,1.462328957,9.36e-10,7.729999999999998e-19,-1.462328957 +urn:mavedb:00000041-a-1#1617,NA,NA,p.Ala142Val,1.363482626,8.53e-13,1.07e-24,-1.363482626 +urn:mavedb:00000041-a-1#1618,NA,NA,p.Ala142Tyr,1.652547624,8.019999999999999e-08,3.76e-15,-1.652547624 +urn:mavedb:00000041-a-1#1619,NA,NA,p.Ala142Thr,0.7043639009999999,9.21e-27,6.389999999999998e-52,-0.7043639009999999 +urn:mavedb:00000041-a-1#1620,NA,NA,p.Ala142Ter,1.278705315,1.87e-33,5.23e-65,-1.278705315 +urn:mavedb:00000041-a-1#1621,NA,NA,p.Ala142Ser,0.979248569,1.2699999999999998e-31,1.9799999999999998e-61,-0.979248569 +urn:mavedb:00000041-a-1#1622,NA,NA,p.Ala142Met,1.116106248,9.21e-18,2.33e-34,-1.116106248 +urn:mavedb:00000041-a-1#1623,NA,NA,p.Ala142Leu,1.5054893230000002,6.79e-08,2.7100000000000006e-15,-1.5054893230000002 +urn:mavedb:00000041-a-1#1624,NA,NA,p.Ala142Ile,1.676692875,1.97e-14,7.19e-28,-1.676692875 +urn:mavedb:00000041-a-1#1625,NA,NA,p.Ala142His,1.5203136730000002,9.98e-21,4.0499999999999984e-40,-1.5203136730000002 +urn:mavedb:00000041-a-1#1626,NA,NA,p.Ala142Gly,1.5193547630000002,6.42e-10,3.76e-19,-1.5193547630000002 +urn:mavedb:00000041-a-1#1627,NA,NA,p.Ala142Glu,1.648558758,7.99e-06,2.05e-11,-1.648558758 +urn:mavedb:00000041-a-1#1628,NA,NA,p.Ala142Gln,1.64321843,4e-08,9.900000000000001e-16,-1.64321843 +urn:mavedb:00000041-a-1#1629,NA,NA,p.Ala142Asp,1.559698331,0.000275854,1.1100000000000002e-08,-1.559698331 +urn:mavedb:00000041-a-1#1630,NA,NA,p.Ala142Asn,2.054579604,2.38e-09,4.5400000000000005e-18,-2.054579604 +urn:mavedb:00000041-a-1#1631,NA,NA,p.Ala142Arg,1.60583874,5.73e-10,3.02e-19,-1.60583874 +urn:mavedb:00000041-a-1#1632,NA,NA,p.Ala137Val,1.486905325,3.14e-09,7.88e-18,-1.486905325 +urn:mavedb:00000041-a-1#1633,NA,NA,p.Ala137Tyr,1.589791524,6.509999999999999e-09,3.16e-17,-1.589791524 +urn:mavedb:00000041-a-1#1634,NA,NA,p.Ala137Thr,1.459540653,0.15058099,0.001367859,-1.459540653 +urn:mavedb:00000041-a-1#1635,NA,NA,p.Ala137Ter,1.711585872,1.15e-11,1.63e-22,-1.711585872 +urn:mavedb:00000041-a-1#1636,NA,NA,p.Ala137Ser,0.75479012,4.11e-15,3.4000000000000003e-29,-0.75479012 +urn:mavedb:00000041-a-1#1637,NA,NA,p.Ala137Pro,1.568783885,9.59e-11,9.63e-21,-1.568783885 +urn:mavedb:00000041-a-1#1638,NA,NA,p.Ala137Lys,1.551386644,2.82e-13,1.26e-25,-1.551386644 +urn:mavedb:00000041-a-1#1639,NA,NA,p.Ala137Leu,1.455140026,1.65e-17,7.66e-34,-1.455140026 +urn:mavedb:00000041-a-1#1640,NA,NA,p.Ala137Ile,1.605894644,0.369899387,5.05e-07,-1.605894644 +urn:mavedb:00000041-a-1#1641,NA,NA,p.Ala137Glu,1.52039556,2.5e-05,1.6199999999999998e-10,-1.52039556 +urn:mavedb:00000041-a-1#1642,NA,NA,p.Ala137Asp,1.379233067,4.66e-14,3.83e-27,-1.379233067 +urn:mavedb:00000041-a-1#1643,NA,NA,p.Ala137Asn,1.36242443,7.79e-08,3.5100000000000002e-15,-1.36242443 +urn:mavedb:00000041-a-1#1644,NA,NA,p.Ala137Arg,1.624014961,1.04e-15,2.4099999999999998e-30,-1.624014961 +urn:mavedb:00000041-a-1#1645,NA,NA,p.Ala124Ser,0.494278631,0.212237968,6.31e-16,-0.494278631 +urn:mavedb:00000041-a-1#1646,NA,NA,p.Ala124Pro,1.097335663,5.570000000000001e-16,7.12e-31,-1.097335663 +urn:mavedb:00000041-a-1#1647,NA,NA,p.Ala124Phe,1.5770363930000002,7.67e-09,4.31e-17,-1.5770363930000002 +urn:mavedb:00000041-a-1#1648,NA,NA,p.Ala124Lys,1.4117936030000002,0.009768556,8.09e-07,-1.4117936030000002 +urn:mavedb:00000041-a-1#1649,NA,NA,p.Ala124Leu,1.46221113,2.07e-15,9.2e-30,-1.46221113 +urn:mavedb:00000041-a-1#1650,NA,NA,p.Ala124Ile,1.0299167059999998,1.6199999999999999e-15,5.6e-30,-1.0299167059999998 +urn:mavedb:00000041-a-1#1651,NA,NA,p.Ala124Gly,0.902096046,3.34e-24,6.509999999999999e-47,-0.902096046 +urn:mavedb:00000041-a-1#1652,NA,NA,p.Ala124Gln,0.806202867,2.02e-08,2.56e-16,-0.806202867 +urn:mavedb:00000041-a-1#1653,NA,NA,p.Ala124Cys,0.559561235,0.253841851,3.0500000000000005e-11,-0.559561235 +urn:mavedb:00000041-a-1#1654,NA,NA,p.Ala124Arg,1.45672748,0.020079003,1.4300000000000004e-05,-1.45672748 +urn:mavedb:00000041-a-1#1655,NA,NA,p.Ala123Pro,1.514189582,0.004581818,4.870000000000001e-07,-1.514189582 +urn:mavedb:00000041-a-1#1656,NA,NA,p.Ala123Ile,0.572847088,1.01e-08,6.759999999999999e-17,-0.572847088 +urn:mavedb:00000041-a-1#1657,NA,NA,p.Ala109Pro,1.656634296,8.98e-06,2.49e-11,-1.656634296 +urn:mavedb:00000041-a-1#1658,NA,NA,p.Ala105Tyr,1.601380844,6.389999999999999e-44,1.619999999999999e-85,-1.601380844 +urn:mavedb:00000041-a-1#1659,NA,NA,p.Ala105Ter,1.634298785,8.55e-09,5.35e-17,-1.634298785 +urn:mavedb:00000041-a-1#1660,NA,NA,p.Ala105Pro,1.5431757330000002,1.09e-10,1.21e-20,-1.5431757330000002 +urn:mavedb:00000041-a-1#1661,NA,NA,p.Ala105Phe,1.245313789,4.72e-22,1.03e-42,-1.245313789 +urn:mavedb:00000041-a-1#1662,NA,NA,p.Ala105Met,0.609234241,4.36e-27,1.4799999999999992e-52,-0.609234241 +urn:mavedb:00000041-a-1#1663,NA,NA,p.Ala105Lys,1.7782285130000002,0.039751371,8.18e-05,-1.7782285130000002 +urn:mavedb:00000041-a-1#1664,NA,NA,p.Ala105Gly,0.78879845,0.000604536,3.32e-08,-0.78879845 +urn:mavedb:00000041-a-1#1665,NA,NA,p.Ala105Gln,1.556677071,0.045810018,0.000124025,-1.556677071 +urn:mavedb:00000041-a-1#1666,NA,NA,p.Ala105Asp,1.665487134,0.305388039,0.000422352,-1.665487134 +urn:mavedb:00000041-a-1#1667,NA,NA,p.Ala105Asn,0.71527318,0.201153528,0.000152108,-0.71527318 +urn:mavedb:00000041-a-1#1668,NA,NA,p.Ala105Arg,1.545323634,1.3699999999999995e-13,3.1300000000000003e-26,-1.545323634 +urn:mavedb:00000041-a-1#1669,NA,NA,p.Ala102Ter,1.547478551,2.95e-06,3.21e-12,-1.547478551 +urn:mavedb:00000041-a-1#1670,NA,NA,p.Ala102Pro,1.228557593,3.16e-09,7.87e-18,-1.228557593 +urn:mavedb:00000041-a-1#1671,NA,NA,p.Ala102Cys,0.587725504,8.33e-08,3.91e-15,-0.587725504 +urn:mavedb:00000041-a-1#1672,NA,NA,p.Ala101Tyr,1.6388934030000002,3.4500000000000005e-10,1.1300000000000002e-19,-1.6388934030000002 +urn:mavedb:00000041-a-1#1673,NA,NA,p.Ala101Thr,0.755402845,0.392268127,8.329999999999998e-17,-0.755402845 +urn:mavedb:00000041-a-1#1674,NA,NA,p.Ala101Ter,1.6054310180000002,0.000935316,8.060000000000001e-08,-1.6054310180000002 +urn:mavedb:00000041-a-1#1675,NA,NA,p.Ala101Pro,1.175347422,0.00028167700000000003,1.1100000000000002e-08,-1.175347422 +urn:mavedb:00000041-a-1#1676,NA,NA,p.Ala101Phe,1.4681313319999998,1.6800000000000004e-09,2.3599999999999998e-18,-1.4681313319999998 +urn:mavedb:00000041-a-1#1677,NA,NA,p.Ala101Lys,1.495586939,2.34e-12,7.46e-24,-1.495586939 +urn:mavedb:00000041-a-1#1678,NA,NA,p.Ala101His,1.550962299,8.499999999999998e-13,1.06e-24,-1.550962299 +urn:mavedb:00000041-a-1#1679,NA,NA,p.Ala101Glu,1.193538073,3.66e-10,1.25e-19,-1.193538073 +urn:mavedb:00000041-a-1#1680,NA,NA,p.Ala101Gln,0.780373093,4.67e-24,1.24e-46,-0.780373093 +urn:mavedb:00000041-a-1#1681,NA,NA,p.Ala101Asp,1.514492736,3.35e-05,2.8e-10,-1.514492736 +urn:mavedb:00000041-a-1#1682,NA,NA,p.Ala101Asn,1.178047822,2.6499999999999998e-18,2.1499999999999998e-35,-1.178047822 +urn:mavedb:00000041-a-1#1683,NA,NA,p.Ala101Arg,1.533855375,1.48e-10,2.2200000000000003e-20,-1.533855375 +urn:mavedb:00000041-a-1#1684,NA,NA,p.Ala61Val,1.151060608,4.71e-07,1.0300000000000003e-13,-1.151060608 +urn:mavedb:00000041-a-1#1685,NA,NA,p.Ala61Pro,1.487787651,2.32e-05,1.38e-10,-1.487787651 +urn:mavedb:00000041-a-1#1686,NA,NA,p.Ala61Met,0.766481964,3.85e-15,3.01e-29,-0.766481964 +urn:mavedb:00000041-a-1#1687,NA,NA,p.Ala61Leu,1.4872367569999998,0.318622618,1.2e-05,-1.4872367569999998 +urn:mavedb:00000041-a-1#1688,NA,NA,p.Ala61Ile,1.088310008,5.14e-17,7.009999999999998e-33,-1.088310008 +urn:mavedb:00000041-a-1#1689,NA,NA,p.Ala61Gly,0.7518407840000001,1.5099999999999992e-81,2.749999999999998e-159,-0.7518407840000001 +urn:mavedb:00000041-a-1#1690,NA,NA,p.Ala61Glu,1.4913905319999998,0.000127896,2.98e-09,-1.4913905319999998 +urn:mavedb:00000041-a-1#1691,NA,NA,p.Ala61Asp,1.362273835,2.1e-10,4.35e-20,-1.362273835 +urn:mavedb:00000041-a-1#1692,NA,NA,p.Ala45Val,1.273384549,4.33e-18,5.579999999999998e-35,-1.273384549 +urn:mavedb:00000041-a-1#1693,NA,NA,p.Ala45Tyr,1.454942149,7.020000000000002e-09,3.61e-17,-1.454942149 +urn:mavedb:00000041-a-1#1694,NA,NA,p.Ala45Thr,1.460767563,3.28e-10,1.0299999999999999e-19,-1.460767563 +urn:mavedb:00000041-a-1#1695,NA,NA,p.Ala45Ter,1.613418417,6.96e-08,2.8600000000000003e-15,-1.613418417 +urn:mavedb:00000041-a-1#1696,NA,NA,p.Ala45Ser,0.7929965790000001,8.77e-09,5.36e-17,-0.7929965790000001 +urn:mavedb:00000041-a-1#1697,NA,NA,p.Ala45Pro,1.460901592,1.5e-11,2.72e-22,-1.460901592 +urn:mavedb:00000041-a-1#1698,NA,NA,p.Ala45Phe,1.599955049,1.88e-05,9.46e-11,-1.599955049 +urn:mavedb:00000041-a-1#1699,NA,NA,p.Ala45Met,1.519701388,8.51e-07,3.16e-13,-1.519701388 +urn:mavedb:00000041-a-1#1700,NA,NA,p.Ala45Lys,1.435325935,1.42e-13,3.32e-26,-1.435325935 +urn:mavedb:00000041-a-1#1701,NA,NA,p.Ala45Leu,1.502737847,1.46e-09,1.82e-18,-1.502737847 +urn:mavedb:00000041-a-1#1702,NA,NA,p.Ala45Ile,1.34064385,2.5000000000000003e-12,8.55e-24,-1.34064385 +urn:mavedb:00000041-a-1#1703,NA,NA,p.Ala45His,1.519716315,3.5600000000000005e-05,3.08e-10,-1.519716315 +urn:mavedb:00000041-a-1#1704,NA,NA,p.Ala45Glu,1.4713218680000002,0.34548498200000005,3.44e-07,-1.4713218680000002 +urn:mavedb:00000041-a-1#1705,NA,NA,p.Ala45Cys,1.034602091,6.940000000000001e-15,9.49e-29,-1.034602091 +urn:mavedb:00000041-a-1#1706,NA,NA,p.Ala45Asp,1.516050273,2.01e-05,1.1e-10,-1.516050273 +urn:mavedb:00000041-a-1#1707,NA,NA,p.Ala45Asn,1.537307771,2.02e-05,1.1e-10,-1.537307771 +urn:mavedb:00000041-a-1#1708,NA,NA,p.Ala45Arg,1.4456808069999998,5.1e-06,8.869999999999999e-12,-1.4456808069999998 +urn:mavedb:00000041-a-1#1709,NA,NA,p.Ala27Val,1.398578806,2.53e-10,6.28e-20,-1.398578806 +urn:mavedb:00000041-a-1#1710,NA,NA,p.Ala27Ter,1.6833280309999998,2.2e-23,2.6300000000000004e-45,-1.6833280309999998 +urn:mavedb:00000041-a-1#1711,NA,NA,p.Ala27Ser,1.078247456,1.14e-44,5.489999999999998e-87,-1.078247456 +urn:mavedb:00000041-a-1#1712,NA,NA,p.Ala27Phe,1.603328766,5.71e-10,2.99e-19,-1.603328766 +urn:mavedb:00000041-a-1#1713,NA,NA,p.Ala27Leu,1.569647269,7.620000000000001e-08,3.3700000000000003e-15,-1.569647269 +urn:mavedb:00000041-a-1#1714,NA,NA,p.Ala27Ile,1.651312497,0.418453842,9.24e-09,-1.651312497 +urn:mavedb:00000041-a-1#1715,NA,NA,p.Ala27Gly,1.130345238,4.61e-15,4.14e-29,-1.130345238 +urn:mavedb:00000041-a-1#1716,NA,NA,p.Ala27Glu,1.602230795,9.65e-07,3.94e-13,-1.602230795 +urn:mavedb:00000041-a-1#1717,NA,NA,p.Ala27Asp,1.5882109269999998,1.3099999999999999e-23,9.569999999999999e-46,-1.5882109269999998 +urn:mavedb:00000041-a-1#1718,NA,NA,p.Ala27Asn,1.922717041,0.328239716,2.98e-06,-1.922717041 +urn:mavedb:00000041-a-1#1719,NA,NA,p.Ala27Arg,1.4457537809999998,1.7699999999999998e-11,3.74e-22,-1.4457537809999998 +urn:mavedb:00000041-a-1#1720,NA,NA,p.Val209Thr,-0.674159733,0.003724254,6.54e-07,0.674159733 +urn:mavedb:00000041-a-1#1721,NA,NA,p.Val209Ile,-0.6575943910000001,1.61e-18,8.18e-36,0.6575943910000001 +urn:mavedb:00000041-a-1#1722,NA,NA,p.Val201Ser,-1.178356187,6.93e-11,5.310000000000001e-21,1.178356187 +urn:mavedb:00000041-a-1#1723,NA,NA,p.Val201Gly,-1.597872739,6.309999999999997e-95,1.679999999999999e-185,1.597872739 +urn:mavedb:00000041-a-1#1724,NA,NA,p.Val201Asp,-0.750558864,7.61e-15,1.18e-28,0.750558864 +urn:mavedb:00000041-a-1#1725,NA,NA,p.Val195Thr,-0.994031125,3.8900000000000007e-28,1.3599999999999993e-54,0.994031125 +urn:mavedb:00000041-a-1#1726,NA,NA,p.Val195Ser,-0.873465495,8.609999999999999e-36,1.4099999999999992e-69,0.873465495 +urn:mavedb:00000041-a-1#1727,NA,NA,p.Val195His,-0.93051678,1.06e-12,1.69e-24,0.93051678 +urn:mavedb:00000041-a-1#1728,NA,NA,p.Val179Ile,-0.67989383,1.39e-41,6.299999999999997e-81,0.67989383 +urn:mavedb:00000041-a-1#1729,NA,NA,p.Val133His,-1.033920714,1.2052533559999998,0.0,1.033920714 +urn:mavedb:00000041-a-1#1730,NA,NA,p.Val117Ile,-1.087878102,1.67e-16,6.92e-32,1.087878102 +urn:mavedb:00000041-a-1#1731,NA,NA,p.Val111Trp,-1.320644725,6.32e-37,8.48e-72,1.320644725 +urn:mavedb:00000041-a-1#1732,NA,NA,p.Val111Met,-1.222339939,4.55e-56,2.58e-109,1.222339939 +urn:mavedb:00000041-a-1#1733,NA,NA,p.Val98His,-0.6797543640000001,0.624206143,2.39e-06,0.6797543640000001 +urn:mavedb:00000041-a-1#1734,NA,NA,p.Val98Arg,-0.862834717,7.97e-22,2.85e-42,0.862834717 +urn:mavedb:00000041-a-1#1735,NA,NA,p.Val62Met,-1.398137445,3.93e-18,4.88e-35,1.398137445 +urn:mavedb:00000041-a-1#1736,NA,NA,p.Val62Cys,-0.946973549,2.879999999999999e-54,8.669999999999995e-106,0.946973549 +urn:mavedb:00000041-a-1#1737,NA,NA,p.Val57Asn,-1.023287283,5.29e-16,6.29e-31,1.023287283 +urn:mavedb:00000041-a-1#1738,NA,NA,p.Val57Arg,-2.512498332,5.089999999999999e-54,2.699999999999999e-105,2.512498332 +urn:mavedb:00000041-a-1#1739,NA,NA,p.Val47Ile,-0.777365761,0.097782112,8.029999999999999e-10,0.777365761 +urn:mavedb:00000041-a-1#1740,NA,NA,p.Val5Trp,-2.977879804,1.6099999999999997e-37,6.009999999999997e-73,2.977879804 +urn:mavedb:00000041-a-1#1741,NA,NA,p.Val5Thr,-1.125598312,4.479999999999999e-45,8.969999999999995e-88,1.125598312 +urn:mavedb:00000041-a-1#1742,NA,NA,p.Val5Ser,-2.445162676,2.84e-16,2.01e-31,2.445162676 +urn:mavedb:00000041-a-1#1743,NA,NA,p.Val5Pro,-2.92269163,8.83e-53,7.499999999999996e-103,2.92269163 +urn:mavedb:00000041-a-1#1744,NA,NA,p.Val5Met,-1.276818293,1.4600000000000002e-26,1.669999999999999e-51,1.276818293 +urn:mavedb:00000041-a-1#1745,NA,NA,p.Val5Gly,-4.551151345,3.3e-23,6.229999999999998e-45,4.551151345 +urn:mavedb:00000041-a-1#1746,NA,NA,p.Val5Cys,-2.88148288,9.779999999999999e-36,1.86e-69,2.88148288 +urn:mavedb:00000041-a-1#1747,NA,NA,p.Val5Asp,-0.780821915,9.26e-28,7.499999999999997e-54,0.780821915 +urn:mavedb:00000041-a-1#1748,NA,NA,p.Val5Asn,-0.8370509079999999,3.3600000000000004e-05,3.26e-10,0.8370509079999999 +urn:mavedb:00000041-a-1#1749,NA,NA,p.Val5Arg,-1.425989242,3.85e-18,4.7099999999999997e-35,1.425989242 +urn:mavedb:00000041-a-1#1750,NA,NA,p.Val5Ala,-1.913071123,1.4199999999999995e-63,5.009999999999997e-124,1.913071123 +urn:mavedb:00000041-a-1#1751,NA,NA,p.Tyr245Arg,-1.65915136,3.3600000000000004e-57,1.5599999999999991e-111,1.65915136 +urn:mavedb:00000041-a-1#1752,NA,NA,p.Tyr116Val,-1.765844334,9.59e-07,4.370000000000001e-13,1.765844334 +urn:mavedb:00000041-a-1#1753,NA,NA,p.Tyr116Ile,-1.770558074,1.08e-33,1.86e-65,1.770558074 +urn:mavedb:00000041-a-1#1754,NA,NA,p.Tyr74Arg,-2.341061495,1.83e-10,3.69e-20,2.341061495 +urn:mavedb:00000041-a-1#1755,NA,NA,p.Tyr69Leu,-1.730569868,0.296981494,0.000565919,1.730569868 +urn:mavedb:00000041-a-1#1756,NA,NA,p.Tyr60Ile,-1.588378434,1.03e-17,3.19e-34,1.588378434 +urn:mavedb:00000041-a-1#1757,NA,NA,p.Tyr60Arg,-1.994826388,3.77e-29,1.47e-56,1.994826388 +urn:mavedb:00000041-a-1#1758,NA,NA,p.Trp20Val,-0.769790028,1.36e-10,1.9699999999999998e-20,0.769790028 +urn:mavedb:00000041-a-1#1759,NA,NA,p.Trp20Thr,-0.771776343,1.25e-06,6.82e-13,0.771776343 +urn:mavedb:00000041-a-1#1760,NA,NA,p.Trp20Lys,-2.197690221,1.5e-26,1.739999999999999e-51,2.197690221 +urn:mavedb:00000041-a-1#1761,NA,NA,p.Trp20Ile,-0.68685351,2.8e-10,7.53e-20,0.68685351 +urn:mavedb:00000041-a-1#1762,NA,NA,p.Trp20His,-1.176219518,2.59e-12,9.89e-24,1.176219518 +urn:mavedb:00000041-a-1#1763,NA,NA,p.Trp20Glu,-1.116238529,1.84e-28,3.18e-55,1.116238529 +urn:mavedb:00000041-a-1#1764,NA,NA,p.Trp20Gln,-0.955037254,1.9499999999999998e-61,7.689999999999997e-120,0.955037254 +urn:mavedb:00000041-a-1#1765,NA,NA,p.Trp20Cys,-1.297608905,3.37e-09,9.84e-18,1.297608905 +urn:mavedb:00000041-a-1#1766,NA,NA,p.Trp20Asp,-0.7982497209999999,1.1e-06,5.04e-13,0.7982497209999999 +urn:mavedb:00000041-a-1#1767,NA,NA,p.Trp20Asn,-0.658486852,0.6910772340000001,1.2e-10,0.658486852 +urn:mavedb:00000041-a-1#1768,NA,NA,p.Trp20Arg,-0.748248714,8.550000000000001e-16,1.68e-30,0.748248714 +urn:mavedb:00000041-a-1#1769,NA,NA,p.Trp16Val,-3.612409151,7.73e-24,3.67e-46,3.612409151 +urn:mavedb:00000041-a-1#1770,NA,NA,p.Trp16Tyr,-2.398624254,1.19e-12,2.13e-24,2.398624254 +urn:mavedb:00000041-a-1#1771,NA,NA,p.Trp16Thr,-5.125043233,3.36e-17,3.29e-33,5.125043233 +urn:mavedb:00000041-a-1#1772,NA,NA,p.Trp16Ser,-2.047980907,2.26e-10,5.650000000000001e-20,2.047980907 +urn:mavedb:00000041-a-1#1773,NA,NA,p.Trp16Phe,-0.7216920170000001,6.09e-17,9.94e-33,0.7216920170000001 +urn:mavedb:00000041-a-1#1774,NA,NA,p.Trp16Met,-3.0603042260000004,4.8499999999999995e-45,1.11e-87,3.0603042260000004 +urn:mavedb:00000041-a-1#1775,NA,NA,p.Trp16Leu,-2.16537328,3.2399999999999997e-34,1.7499999999999995e-66,2.16537328 +urn:mavedb:00000041-a-1#1776,NA,NA,p.Trp16Ile,-2.488207521,4.19e-25,1.2099999999999997e-48,2.488207521 +urn:mavedb:00000041-a-1#1777,NA,NA,p.Trp16His,-1.861503446,2.61e-63,1.639999999999999e-123,1.861503446 +urn:mavedb:00000041-a-1#1778,NA,NA,p.Trp16Gly,-1.401669445,4.87e-08,1.5099999999999999e-15,1.401669445 +urn:mavedb:00000041-a-1#1779,NA,NA,p.Trp16Glu,-1.294484315,5.8899999999999985e-33,5.049999999999998e-64,1.294484315 +urn:mavedb:00000041-a-1#1780,NA,NA,p.Trp16Cys,-2.60320004,1.7199999999999995e-35,5.679999999999996e-69,2.60320004 +urn:mavedb:00000041-a-1#1781,NA,NA,p.Trp16Asp,-0.967638314,1.04e-19,3.8299999999999995e-38,0.967638314 +urn:mavedb:00000041-a-1#1782,NA,NA,p.Trp16Asn,-3.835744845,9.17e-24,5.0499999999999994e-46,3.835744845 +urn:mavedb:00000041-a-1#1783,NA,NA,p.Trp16Arg,-3.221124489,6.610000000000001e-10,4.389999999999999e-19,3.221124489 +urn:mavedb:00000041-a-1#1784,NA,NA,p.Trp16Ala,-2.296786597,8.78e-31,9.269999999999997e-60,2.296786597 +urn:mavedb:00000041-a-1#1785,NA,NA,p.Thr242Val,-0.68915639,2.6899999999999996e-59,1.159999999999999e-115,0.68915639 +urn:mavedb:00000041-a-1#1786,NA,NA,p.Thr242Tyr,-0.9515184,4.559999999999998e-63,4.689999999999996e-123,0.9515184 +urn:mavedb:00000041-a-1#1787,NA,NA,p.Thr242Trp,-1.098124289,1.6799999999999997e-42,9.589999999999997e-83,1.098124289 +urn:mavedb:00000041-a-1#1788,NA,NA,p.Thr242Pro,-1.070060896,8.039999999999996e-81,7.559999999999994e-158,1.070060896 +urn:mavedb:00000041-a-1#1789,NA,NA,p.Thr242Phe,-0.706168508,5.31e-07,1.42e-13,0.706168508 +urn:mavedb:00000041-a-1#1790,NA,NA,p.Thr242Ile,-0.6570705139999999,1.31e-36,3.4499999999999986e-71,0.6570705139999999 +urn:mavedb:00000041-a-1#1791,NA,NA,p.Thr242His,-1.3662771319999998,1.27e-16,4.11e-32,1.3662771319999998 +urn:mavedb:00000041-a-1#1792,NA,NA,p.Thr242Gly,-0.940756705,1.45e-63,5.089999999999999e-124,0.940756705 +urn:mavedb:00000041-a-1#1793,NA,NA,p.Thr242Glu,-0.89035721,1.6499999999999994e-78,2.509999999999998e-153,0.89035721 +urn:mavedb:00000041-a-1#1794,NA,NA,p.Thr242Asp,-1.401798059,2.51e-26,4.6599999999999995e-51,1.401798059 +urn:mavedb:00000041-a-1#1795,NA,NA,p.Thr242Asn,-1.327752488,1.49e-09,1.9199999999999998e-18,1.327752488 +urn:mavedb:00000041-a-1#1796,NA,NA,p.Thr191Tyr,-0.939395438,0.992714062,3.33e-16,0.939395438 +urn:mavedb:00000041-a-1#1797,NA,NA,p.Thr191His,-0.892732324,1.03e-05,3.69e-11,0.892732324 +urn:mavedb:00000041-a-1#1798,NA,NA,p.Thr174Val,-1.3623333709999998,1.51e-31,2.88e-61,1.3623333709999998 +urn:mavedb:00000041-a-1#1799,NA,NA,p.Thr174Tyr,-1.26703406,1.48e-34,3.6799999999999986e-67,1.26703406 +urn:mavedb:00000041-a-1#1800,NA,NA,p.Thr174Trp,-0.7352038000000001,9.24e-47,4.3699999999999995e-91,0.7352038000000001 +urn:mavedb:00000041-a-1#1801,NA,NA,p.Cys221Arg,1.101384645,2.7600000000000004e-09,6.09e-18,-1.101384645 +urn:mavedb:00000041-a-1#1802,NA,NA,p.Cys134Ter,1.569699809,3.460000000000001e-09,9.439999999999999e-18,-1.569699809 +urn:mavedb:00000041-a-1#1803,NA,NA,p.Cys134Phe,0.763781125,0.144498159,0.00031502,-0.763781125 +urn:mavedb:00000041-a-1#1804,NA,NA,p.Cys134Lys,1.5945809969999998,1.99e-18,1.23e-35,-1.5945809969999998 +urn:mavedb:00000041-a-1#1805,NA,NA,p.Cys134Leu,0.5391971329999999,1.8600000000000003e-17,9.229999999999999e-34,-0.5391971329999999 +urn:mavedb:00000041-a-1#1806,NA,NA,p.Cys134Gly,0.8260352959999999,3.64e-10,1.23e-19,-0.8260352959999999 +urn:mavedb:00000041-a-1#1807,NA,NA,p.Cys134Glu,1.605258792,6.8400000000000016e-12,5.97e-23,-1.605258792 +urn:mavedb:00000041-a-1#1808,NA,NA,p.Cys134Gln,1.335868511,2.7000000000000005e-10,6.980000000000001e-20,-1.335868511 +urn:mavedb:00000041-a-1#1809,NA,NA,p.Cys134Arg,1.632057904,6.51e-06,1.41e-11,-1.632057904 +urn:mavedb:00000041-a-1#1810,NA,NA,p.Cys11Val,1.484898391,0.000147711,3.59e-09,-1.484898391 +urn:mavedb:00000041-a-1#1811,NA,NA,p.Cys11Thr,1.393534588,8.55e-05,1.47e-09,-1.393534588 +urn:mavedb:00000041-a-1#1812,NA,NA,p.Cys11Ter,1.579428359,1.61e-10,2.64e-20,-1.579428359 +urn:mavedb:00000041-a-1#1813,NA,NA,p.Cys11Ser,1.027270948,2.19e-32,6.449999999999997e-63,-1.027270948 +urn:mavedb:00000041-a-1#1814,NA,NA,p.Cys11Pro,1.620599734,6.759999999999998e-09,3.39e-17,-1.620599734 +urn:mavedb:00000041-a-1#1815,NA,NA,p.Cys11Met,1.283065388,2.3e-27,4.259999999999998e-53,-1.283065388 +urn:mavedb:00000041-a-1#1816,NA,NA,p.Cys11Lys,1.4380404430000002,6.909999999999999e-15,9.51e-29,-1.4380404430000002 +urn:mavedb:00000041-a-1#1817,NA,NA,p.Cys11Leu,1.309592593,8.41e-13,1.04e-24,-1.309592593 +urn:mavedb:00000041-a-1#1818,NA,NA,p.Cys11Ile,1.511628128,0.000841462,6.38e-08,-1.511628128 +urn:mavedb:00000041-a-1#1819,NA,NA,p.Cys11Gly,0.894382274,3.62e-26,9.299999999999997e-51,-0.894382274 +urn:mavedb:00000041-a-1#1820,NA,NA,p.Cys11Asp,1.4983655530000002,5.75e-06,1.09e-11,-1.4983655530000002 +urn:mavedb:00000041-a-1#1821,NA,NA,p.Cys11Asn,0.6818763290000001,0.237548526,1.81e-11,-0.6818763290000001 +urn:mavedb:00000041-a-1#1822,NA,NA,p.Cys11Arg,1.586246387,6.42e-06,1.34e-11,-1.586246387 +urn:mavedb:00000041-a-1#1824,NA,NA,p.Asp178Val,1.519503871,3.25e-09,8.390000000000001e-18,-1.519503871 +urn:mavedb:00000041-a-1#1825,NA,NA,p.Asp178Tyr,1.477712161,4.11e-12,2.21e-23,-1.477712161 +urn:mavedb:00000041-a-1#1826,NA,NA,p.Asp178Thr,1.629049311,1.53e-10,2.4e-20,-1.629049311 +urn:mavedb:00000041-a-1#1827,NA,NA,p.Asp178Ter,1.670325806,2.55e-07,3.29e-14,-1.670325806 +urn:mavedb:00000041-a-1#1828,NA,NA,p.Thr174Met,-1.645072633,1.56e-09,2.07e-18,1.645072633 +urn:mavedb:00000041-a-1#1829,NA,NA,p.Thr174Leu,-1.342419892,1.2699999999999998e-25,1.12e-49,1.342419892 +urn:mavedb:00000041-a-1#1830,NA,NA,p.Thr174Gln,-0.6942084409999999,1.94e-30,4.11e-59,0.6942084409999999 +urn:mavedb:00000041-a-1#1831,NA,NA,p.Thr174Arg,-0.6681287779999999,6.45e-18,1.21e-34,0.6681287779999999 +urn:mavedb:00000041-a-1#1832,NA,NA,p.Thr151Val,-0.8804926409999999,5.2699999999999986e-20,1.03e-38,0.8804926409999999 +urn:mavedb:00000041-a-1#3496,NA,NA,p.Ala101Ser,-0.236157428,6.63e-10,3.97e-19,0.236157428 +urn:mavedb:00000041-a-1#3497,NA,NA,p.Ala101Met,0.215695017,9.88e-19,3.1e-36,-0.215695017 +urn:mavedb:00000041-a-1#3498,NA,NA,p.Ala101Leu,0.307762957,0.341483804,1.39e-17,-0.307762957 +urn:mavedb:00000041-a-1#3499,NA,NA,p.Ala101Ile,-0.082817124,2.41e-10,5.2000000000000005e-20,0.082817124 +urn:mavedb:00000041-a-1#3500,NA,NA,p.Ala101Gly,-0.007530961999999999,8.890000000000002e-23,3.86e-44,0.007530961999999999 +urn:mavedb:00000041-a-1#3501,NA,NA,p.Ala61Ser,0.35632946200000004,0.101444333,8.25e-05,-0.35632946200000004 +urn:mavedb:00000041-a-1#3502,NA,NA,p.Ala61Lys,-0.515932547,0.946832425,0.011483939,0.515932547 +urn:mavedb:00000041-a-1#3503,NA,NA,p.Ala61Gln,0.211651021,2.89e-07,4.24e-14,-0.211651021 +urn:mavedb:00000041-a-1#3504,NA,NA,p.Ala61Asn,0.15008458,0.001928089,4.72e-08,-0.15008458 +urn:mavedb:00000041-a-1#3505,NA,NA,p.Ala45Gly,-0.223628608,1.579999999999999e-118,8.029999999999994e-232,0.223628608 +urn:mavedb:00000041-a-1#3506,NA,NA,p.Ala40Ser,-0.064241699,1.19e-59,2.3199999999999984e-116,0.064241699 diff --git a/tests/unit/test_vrs_map.py b/tests/unit/test_vrs_map.py index f9b2a4a..7ca3f77 100644 --- a/tests/unit/test_vrs_map.py +++ b/tests/unit/test_vrs_map.py @@ -1 +1,109 @@ -"""Test ``vrs_map.py``""" +"""Test ``vrs_map.py`` + +Todo: +---- +* Sample a second mapping row for each test case (also, order shouldn't matter) +* Add a few more test cases + +""" +from typing import Dict + +import pytest +from cool_seq_tool.schemas import TranscriptPriority +from ga4gh.vrs._internal.models import Allele + +from dcd_mapping.resources import get_scoreset_records +from dcd_mapping.schemas import AlignmentResult, ScoresetMetadata, TxSelectResult +from dcd_mapping.vrs_map import vrs_map + + +def test_vrs_map_src( + scoreset_metadata_fixture: Dict[str, ScoresetMetadata], + align_result_fixture: Dict[str, AlignmentResult], + transcript_results_fixture: Dict[str, TxSelectResult], +): + """Test VRS mapping for urn:mavedb:00000041-a-1""" + urn = "urn:mavedb:00000041-a-1" + vrs_mapping_result = vrs_map( + scoreset_metadata_fixture[urn], + align_result_fixture[urn], + transcript_results_fixture[urn], + get_scoreset_records(urn), + ) + assert vrs_mapping_result is not None + mapping = vrs_mapping_result.variations[0] + assert mapping.mavedb_id == "urn:mavedb:00000041-a-1#548" + assert mapping.score == pytest.approx(0.753146338) + + assert isinstance(mapping.pre_mapped, Allele) + assert mapping.pre_mapped.state.sequence == "T" + assert ( + mapping.pre_mapped.location.sequenceReference.refgetAccession + == "ga4gh:SQ.PyX9IDu95_tYLg1Jz9JpW5xpQkwn6bpB" + ) + assert mapping.pre_mapped.location.start == 14 + assert mapping.pre_mapped.location.end == 15 + + assert isinstance(mapping.post_mapped, Allele) + assert mapping.post_mapped.state.sequence == "G" + assert ( + mapping.post_mapped.location.sequenceReference.refgetAccession + == "ga4gh:SQ.uJDQo_HaTNFL2-0-6K5dVzVcweigexye" + ) + assert mapping.post_mapped.location.start == 438 + assert mapping.post_mapped.location.end == 439 + assert mapping.post_mapped.expressions[0]["syntax"] == "hgvs.p" + assert mapping.post_mapped.expressions[0]["value"] == "NP_005408.1:p.Tyr439Gly" + assert mapping.post_mapped.expressions[0]["syntax_version"] is None + + assert mapping.mapped_transcript is not None + assert mapping.mapped_transcript.refseq_nuc == "NM_198291.3" + assert ( + mapping.mapped_transcript.transcript_priority == TranscriptPriority.MANE_SELECT + ) + + +def test_vrs_map_hbb( + scoreset_metadata_fixture: Dict[str, ScoresetMetadata], + align_result_fixture: Dict[str, AlignmentResult], + transcript_results_fixture: Dict[str, TxSelectResult], +): + """Test VRS mapping for urn:mavedb:00000018-a-1""" + urn = "urn:mavedb_id:00000018-a-1" + vrs_mapping_result = vrs_map( + scoreset_metadata_fixture[urn], + align_result_fixture[urn], + transcript_results_fixture[urn], + get_scoreset_records(urn), + ) + assert vrs_mapping_result is not None + mapping = vrs_mapping_result.variations[0] + assert mapping.mavedb_id == "urn:mavedb:00000018-a-1#583" + assert mapping.score == pytest.approx(-0.17) + + assert isinstance(mapping.pre_mapped, Allele) + assert mapping.pre_mapped.state.sequence == "G" + assert ( + mapping.pre_mapped.location.sequenceReference.refgetAccession + == "ga4gh:SQ.jUOcLPDjSqWFEo9kSOG8ITe1dr9QK3h6" + ) + assert mapping.pre_mapped.location.start == 186 + assert mapping.pre_mapped.location.end == 187 + + assert isinstance(mapping.post_mapped, Allele) + assert mapping.post_mapped.state.sequence == "G" + assert ( + mapping.post_mapped.location.sequenceReference.refgetAccession + == "ga4gh:SQ.2NkFm8HK88MqeNkCgj78KidCAXgnsfV1" + ) + assert mapping.post_mapped.location.start == 5227207 + assert mapping.post_mapped.location.end == 5227208 + assert mapping.post_mapped.expressions[0]["syntax"] == "hgvs.g" + assert mapping.post_mapped.expressions[0]["value"] == "NC_000011.10:g.5227208T>G" + assert mapping.post_mapped.expressions[0]["syntax_version"] is None + + assert mapping.mapped_transcript is not None + assert mapping.mapped_transcript.refseq_nuc == "NM_198291.3" + assert ( + mapping.mapped_transcript.transcript_priority == TranscriptPriority.MANE_SELECT + )