diff --git a/src/__tests__/fixtures/MockStubs.ts b/src/__tests__/fixtures/MockStubs.ts
index 1adf209..9e5eae0 100644
--- a/src/__tests__/fixtures/MockStubs.ts
+++ b/src/__tests__/fixtures/MockStubs.ts
@@ -29,6 +29,7 @@ export const xmlContent = `<?xml version="1.0"?>
 
     <owl:Class rdf:about="class3">
         <rdfs:subClassOf rdf:resource="http://class2/label2"/>
+        <owl:disjointWith rdf:resource="aDescription5"/>
         <rdfs:label rdf:datatype="aLabel">label3</rdfs:label>
         <owl:equivalentClass rdf:resource="class6"/>
         <owl:equivalentClass rdf:resource="class7"/>
diff --git a/src/__tests__/unit/technique-getter.unit.ts b/src/__tests__/unit/technique-getter.unit.ts
index 919dbe0..c76ea02 100644
--- a/src/__tests__/unit/technique-getter.unit.ts
+++ b/src/__tests__/unit/technique-getter.unit.ts
@@ -348,11 +348,7 @@ describe('GitHubOwlTechnique', () => {
   describe('parents', () => {
     it('checks the parents from the xml queried file', done => {
       const item = querySelectorXml[2];
-      const parents = [
-        'http://class2/label2',
-        'aDescription5',
-        'aDescription6',
-      ];
+      const parents = ['http://class2/label2', 'aDescription6'];
       expect(GitHubOwlTechnique.parents(item)).to.be.eql(parents);
       done();
     });
@@ -406,7 +402,6 @@ describe('GitHubOwlTechnique', () => {
             prefLabel: 'label3',
             parents: [
               'http://class2/label2',
-              'aDescription5',
               'aDescription6',
               'class1',
               'class5',
@@ -419,7 +414,6 @@ describe('GitHubOwlTechnique', () => {
           class1: new Set(['class1', 'class3']),
           'http://class2/label2': new Set(['http://class2/label2', 'class3']),
           class3: new Set(['class3']),
-          aDescription5: new Set(['aDescription5', 'class3']),
           aDescription6: new Set(['aDescription6', 'class3']),
           class5: new Set(['class5', 'class3']),
         },
@@ -527,4 +521,16 @@ describe('GitHubOwlTechnique', () => {
       done();
     });
   });
+
+  describe('disjointWith', () => {
+    it('checks the equivalentClass from the xml queried file', done => {
+      expect(GitHubOwlTechnique.disjointWith(querySelectorXml[2])).to.be.eql([
+        'aDescription5',
+      ]);
+      expect(GitHubOwlTechnique.disjointClasses).to.be.eql({
+        class3: ['aDescription5'],
+      });
+      done();
+    });
+  });
 });
diff --git a/src/misc/technique-getter.ts b/src/misc/technique-getter.ts
index d565c90..13f21c6 100644
--- a/src/misc/technique-getter.ts
+++ b/src/misc/technique-getter.ts
@@ -122,6 +122,7 @@ export class GitHubOwlTechnique extends OntologyTechnique {
   url: string;
   collection: OwlTechniqueCollection[];
   equivalentClasses: {[key: string]: string[]};
+  disjointClasses: {[key: string]: string[]};
 
   constructor(config: GitHubGetter) {
     super();
@@ -134,6 +135,7 @@ export class GitHubOwlTechnique extends OntologyTechnique {
       : 'latest/download';
     this.file = config.file ?? 'PaNET.owl';
     this.equivalentClasses = {};
+    this.disjointClasses = {};
     this.keys.push(...['prefLabel', 'synonym']);
   }
 
@@ -222,10 +224,9 @@ export class GitHubOwlTechnique extends OntologyTechnique {
       parentsList.push(parent);
       i++;
     }
-    const parents = [
-      ...new Set([...parentsList, ...this.equivalentClass(item)]),
-    ];
-    return parents;
+    const parents = new Set([...parentsList, ...this.equivalentClass(item)]);
+    this.disjointWith(item).forEach(disjoint => parents.delete(disjoint));
+    return [...parents];
   }
 
   buildNodes(
@@ -264,6 +265,20 @@ export class GitHubOwlTechnique extends OntologyTechnique {
     ];
   }
 
+  disjointWith(item: Element) {
+    const pid = this.pid(item);
+    const disjointClasses = item.getElementsByTagName('owl:disjointWith');
+    let i = 0;
+    const disjoints = [];
+    while (i < disjointClasses.length) {
+      const klass = this.pid(disjointClasses[i], 'rdf:resource');
+      if (klass) disjoints.push(klass);
+      i++;
+    }
+    this.disjointClasses[pid] = disjoints;
+    return disjoints;
+  }
+
   processInCollectionLoop(
     node: OwlTechniqueCollection,
     o: GitHubTechniqueNodes,
@@ -281,6 +296,14 @@ export class GitHubOwlTechnique extends OntologyTechnique {
       o['leaves'] = o['leaves'].concat(this.filterLeaves(e));
     });
   }
+
+  async build(): Promise<this> {
+    await super.build();
+    Object.entries(this.disjointClasses).map(([key, value]) =>
+      value.forEach(v => this.relatives[key].delete(v)),
+    );
+    return this;
+  }
 }
 
 export class BioPortalTechniques extends OntologyTechnique {