diff --git a/packages/calcite-components/src/components/carousel/carousel.e2e.ts b/packages/calcite-components/src/components/carousel/carousel.e2e.ts
index 33c767870fc..02313e8ea9e 100644
--- a/packages/calcite-components/src/components/carousel/carousel.e2e.ts
+++ b/packages/calcite-components/src/components/carousel/carousel.e2e.ts
@@ -930,4 +930,55 @@ describe("calcite-carousel", () => {
       expect(selectedItem.id).toEqual("two");
     });
   });
+
+  it("item slide animation finishes between paging/selection", async () => {
+    const page = await newE2EPage();
+    await page.setContent(
+      html`<calcite-carousel label="carousel">
+        <calcite-carousel-item label="item 1" selected><p>first</p></calcite-carousel-item>
+        <calcite-carousel-item label="item 2"><p>second</p></calcite-carousel-item>
+        <calcite-carousel-item label="item 3"><p>third</p></calcite-carousel-item>
+      </calcite-carousel>`,
+    );
+
+    const container = await page.find(`calcite-carousel >>> .${CSS.container}`);
+    const animationStartSpy = await container.spyOnEvent("animationstart");
+    const animationEndSpy = await container.spyOnEvent("animationend");
+    const nextButton = await page.find(`calcite-carousel >>> .${CSS.pageNext}`);
+
+    await nextButton.click();
+    await page.waitForChanges();
+    await nextButton.click();
+    await page.waitForChanges();
+
+    expect(animationStartSpy).toHaveReceivedEventTimes(2);
+    expect(animationEndSpy).toHaveReceivedEventTimes(2);
+
+    const previousButton = await page.find(`calcite-carousel >>> .${CSS.pagePrevious}`);
+    await previousButton.click();
+    await page.waitForChanges();
+    await previousButton.click();
+    await page.waitForChanges();
+
+    expect(animationStartSpy).toHaveReceivedEventTimes(4);
+    expect(animationEndSpy).toHaveReceivedEventTimes(4);
+
+    const [item1, item2, item3] = await page.findAll(`calcite-carousel >>> .${CSS.paginationItemIndividual}`);
+
+    await item2.click();
+    await page.waitForChanges();
+    await item3.click();
+    await page.waitForChanges();
+
+    expect(animationStartSpy).toHaveReceivedEventTimes(6);
+    expect(animationEndSpy).toHaveReceivedEventTimes(6);
+
+    await item2.click();
+    await page.waitForChanges();
+    await item1.click();
+    await page.waitForChanges();
+
+    expect(animationStartSpy).toHaveReceivedEventTimes(8);
+    expect(animationEndSpy).toHaveReceivedEventTimes(8);
+  });
 });
diff --git a/packages/calcite-components/src/components/carousel/carousel.tsx b/packages/calcite-components/src/components/carousel/carousel.tsx
index c1e42482b57..dd1fb9edadf 100644
--- a/packages/calcite-components/src/components/carousel/carousel.tsx
+++ b/packages/calcite-components/src/components/carousel/carousel.tsx
@@ -16,6 +16,7 @@ import {
   getElementDir,
   slotChangeGetAssignedElements,
   toAriaBoolean,
+  whenAnimationDone,
 } from "../../utils/dom";
 import { connectLocalized, disconnectLocalized, LocalizedComponent } from "../../utils/locale";
 import { guid } from "../../utils/guid";
@@ -215,7 +216,20 @@ export class Carousel
 
   @State() items: HTMLCalciteCarouselItemElement[] = [];
 
-  @State() direction: "forward" | "backward";
+  @State() direction: "forward" | "backward" | "standby" = "standby";
+
+  @Watch("direction")
+  async directionWatcher(direction: string): Promise<void> {
+    if (direction === "standby") {
+      return;
+    }
+
+    await whenAnimationDone(
+      this.itemContainer,
+      direction === "forward" ? "item-forward" : "item-backward",
+    );
+    this.direction = "standby";
+  }
 
   @State() defaultMessages: CarouselMessages;
 
@@ -394,18 +408,26 @@ export class Carousel
   private handleArrowClick = (event: MouseEvent): void => {
     const direction = (event.target as HTMLDivElement).dataset.direction;
     if (direction === "next") {
+      this.direction = "forward";
       this.nextItem(true);
     } else if (direction === "previous") {
+      this.direction = "backward";
       this.previousItem();
     }
   };
 
   private handleItemSelection = (event: MouseEvent): void => {
+    const item = event.target as HTMLCalciteActionElement;
+    const requestedPosition = parseInt(item.dataset.index);
+
+    if (requestedPosition === this.selectedIndex) {
+      return;
+    }
+
     if (this.playing) {
       this.handlePause(true);
     }
-    const item = event.target as HTMLCalciteActionElement;
-    const requestedPosition = parseInt(item.dataset.index);
+
     this.direction = requestedPosition > this.selectedIndex ? "forward" : "backward";
     this.setSelectedItem(requestedPosition, true);
   };
@@ -528,6 +550,12 @@ export class Carousel
     this.container = el;
   };
 
+  private itemContainer: HTMLDivElement;
+
+  private storeItemContainerRef = (el: HTMLDivElement): void => {
+    this.itemContainer = el;
+  };
+
   // --------------------------------------------------------------------------
   //
   //  Render Methods
@@ -653,6 +681,8 @@ export class Carousel
                 [CSS.itemContainerBackward]: direction === "backward",
               }}
               id={this.containerId}
+              // eslint-disable-next-line react/jsx-sort-props -- auto-generated by @esri/calcite-components/enforce-ref-last-prop
+              ref={this.storeItemContainerRef}
             >
               <slot onSlotchange={this.handleSlotChange} />
             </section>
diff --git a/packages/calcite-components/src/utils/dom.ts b/packages/calcite-components/src/utils/dom.ts
index ae1de19b596..32bc69c429e 100644
--- a/packages/calcite-components/src/utils/dom.ts
+++ b/packages/calcite-components/src/utils/dom.ts
@@ -653,3 +653,61 @@ export function isBefore(a: HTMLElement, b: HTMLElement): boolean {
   const children = Array.from(a.parentNode.children);
   return children.indexOf(a) < children.indexOf(b);
 }
+
+/**
+ * This util helps determine when an animation has completed.
+ *
+ * @param targetEl The element to watch for the animation to complete.
+ * @param animationName The name of the animation to watch for completion.
+ */
+export async function whenAnimationDone(targetEl: HTMLElement, animationName: string): Promise<void> {
+  const { animationDuration: allDurations, animationName: allNames } = getComputedStyle(targetEl);
+
+  const allDurationsArray = allDurations.split(",");
+  const allPropsArray = allNames.split(",");
+  const propIndex = allPropsArray.indexOf(animationName);
+  const duration =
+    allDurationsArray[propIndex] ??
+    /* Safari will have a single duration value for the shorthand prop when multiple, separate names/props are defined,
+            so we fall back to it if there's no matching prop duration */
+    allDurationsArray[0];
+
+  if (duration === "0s") {
+    return Promise.resolve();
+  }
+
+  const startEvent = "animationstart";
+  const endEvent = "animationend";
+  const cancelEvent = "animationcancel";
+
+  return new Promise<void>((resolve) => {
+    const fallbackTimeoutId = setTimeout(
+      (): void => {
+        targetEl.removeEventListener(startEvent, onStart);
+        targetEl.removeEventListener(endEvent, onEndOrCancel);
+        targetEl.removeEventListener(cancelEvent, onEndOrCancel);
+        resolve();
+      },
+      parseFloat(duration) * 1000,
+    );
+
+    targetEl.addEventListener(startEvent, onStart);
+    targetEl.addEventListener(endEvent, onEndOrCancel);
+    targetEl.addEventListener(cancelEvent, onEndOrCancel);
+
+    function onStart(event: AnimationEvent): void {
+      if (event.animationName === animationName && event.target === targetEl) {
+        clearTimeout(fallbackTimeoutId);
+        targetEl.removeEventListener(startEvent, onStart);
+      }
+    }
+
+    function onEndOrCancel(event: AnimationEvent): void {
+      if (event.animationName === animationName && event.target === targetEl) {
+        targetEl.removeEventListener(endEvent, onEndOrCancel);
+        targetEl.removeEventListener(cancelEvent, onEndOrCancel);
+        resolve();
+      }
+    }
+  });
+}