diff --git a/packages/calcite-components/src/components/alert/alert.e2e.ts b/packages/calcite-components/src/components/alert/alert.e2e.ts
index aad265b893e..3c98f1d01bf 100644
--- a/packages/calcite-components/src/components/alert/alert.e2e.ts
+++ b/packages/calcite-components/src/components/alert/alert.e2e.ts
@@ -328,6 +328,77 @@ describe("calcite-alert", () => {
     expect(await container.isVisible()).toBe(false);
   });
 
+  it("should update number of queued alerts with a calcite-chip when removing an alert", async () => {
+    const page = await newE2EPage();
+    await page.setContent(html`
+      <calcite-button id="buttonOne" onclick="document.querySelector('#first-open').setAttribute('open', '')"
+        >open alert</calcite-button
+      >
+      <calcite-button id="buttonTwo" onclick="document.querySelector('#second-open').setAttribute('open', '')"
+        >open alert</calcite-button
+      >
+
+      <calcite-button id="buttonThree" onclick="document.querySelector('#third-open').setAttribute('open', '')"
+        >open alert</calcite-button
+      >
+
+      <calcite-alert open id="first-open" icon="3d-glasses" scale="l">
+        <div slot="title">Title of alert Uno</div>
+        <div slot="message">Message text of the alert Uno</div>
+        <a slot="link" href="#">Retry</a>
+      </calcite-alert>
+
+      <calcite-alert id="second-open" icon scale="l">
+        <div slot="title">Title of alert Dos</div>
+        <div slot="message">Message text of the alert Dos</div>
+        <a slot="link" href="#">Retry</a>
+      </calcite-alert>
+
+      <calcite-alert id="third-open" icon scale="l">
+        <div slot="title">Title of alert Dos</div>
+        <div slot="message">Message text of the alert Dos</div>
+        <a slot="link" href="#">Retry</a>
+      </calcite-alert>
+    `);
+    const buttonOne = await page.find("#buttonOne");
+    const buttonTwo = await page.find("#buttonTwo");
+    const buttonThree = await page.find("#buttonThree");
+    const alertOne = await page.find("#first-open");
+    const alertTwo = await page.find("#second-open");
+    const alertThree = await page.find("#third-open");
+
+    await buttonOne.click();
+    await page.waitForTimeout(animationDurationInMs);
+    expect(await alertOne.isVisible()).toBe(true);
+
+    await buttonTwo.click();
+    expect(await alertTwo.isVisible()).toBe(true);
+
+    await buttonThree.click();
+    expect(await alertThree.isVisible()).toBe(true);
+
+    const chip = await page.find("calcite-alert[id='first-open'] >>> calcite-chip");
+    const chipQueueCount2 = "+2";
+    expect(await chip.getProperty("value")).toEqual(chipQueueCount2);
+    expect(chip.textContent).toEqual(chipQueueCount2);
+
+    await page.$eval("#third-open", (alert: HTMLCalciteAlertElement) => {
+      alert.remove();
+    });
+    await page.waitForChanges();
+
+    const chipQueueCount1 = "+1";
+    expect(await chip.getProperty("value")).toEqual(chipQueueCount1);
+    expect(chip.textContent).toEqual(chipQueueCount1);
+
+    await page.$eval("#second-open", (alert: HTMLCalciteAlertElement) => {
+      alert.remove();
+    });
+    await page.waitForChanges();
+
+    expect(await page.find("calcite-alert[id='first-open'] >>> calcite-chip")).toBeNull();
+  });
+
   describe("auto-close behavior on queued items", () => {
     it("should display number of queued alerts with a calcite-chip", async () => {
       const page = await newE2EPage();
diff --git a/packages/calcite-components/src/components/alert/alert.tsx b/packages/calcite-components/src/components/alert/alert.tsx
index a5c84406150..c4f3acec46c 100644
--- a/packages/calcite-components/src/components/alert/alert.tsx
+++ b/packages/calcite-components/src/components/alert/alert.tsx
@@ -46,7 +46,7 @@ import {
 import { Kind, Scale } from "../interfaces";
 import { KindIcons } from "../resources";
 import { AlertMessages } from "./assets/alert/t9n";
-import { AlertDuration, Sync } from "./interfaces";
+import { AlertDuration, Sync, Unregister } from "./interfaces";
 import { CSS, DURATIONS, SLOTS } from "./resources";
 
 /**
@@ -203,6 +203,11 @@ export class Alert implements OpenCloseComponent, LoadableComponent, T9nComponen
   }
 
   disconnectedCallback(): void {
+    window.dispatchEvent(
+      new CustomEvent<Unregister>("calciteInternalAlertUnregister", {
+        detail: { alert: this.el }
+      })
+    );
     window.clearTimeout(this.autoCloseTimeoutId);
     window.clearTimeout(this.queueTimeout);
     disconnectOpenCloseComponent(this);
@@ -353,6 +358,19 @@ export class Alert implements OpenCloseComponent, LoadableComponent, T9nComponen
     this.determineActiveAlert();
   }
 
+  // Event is dispatched on the window because the element is not in the DOM so bubbling won't occur.
+  @Listen("calciteInternalAlertUnregister", { target: "window" })
+  alertUnregister(event: CustomEvent<Unregister>): void {
+    const queue = this.queue.filter((el) => el !== event.detail.alert);
+    this.queue = queue;
+
+    window.dispatchEvent(
+      new CustomEvent<Sync>("calciteInternalAlertSync", {
+        detail: { queue }
+      })
+    );
+  }
+
   //--------------------------------------------------------------------------
   //
   //  Public Methods
diff --git a/packages/calcite-components/src/components/alert/interfaces.ts b/packages/calcite-components/src/components/alert/interfaces.ts
index 0ffe0b27966..f3ac1d8bb90 100644
--- a/packages/calcite-components/src/components/alert/interfaces.ts
+++ b/packages/calcite-components/src/components/alert/interfaces.ts
@@ -1,4 +1,9 @@
 export type AlertDuration = "fast" | "medium" | "slow";
+
 export interface Sync {
   queue: HTMLCalciteAlertElement[];
 }
+
+export interface Unregister {
+  alert: HTMLCalciteAlertElement;
+}