diff --git a/packages/calcite-components/src/components.d.ts b/packages/calcite-components/src/components.d.ts
index 4c6763a5815..459c8b51ce6 100644
--- a/packages/calcite-components/src/components.d.ts
+++ b/packages/calcite-components/src/components.d.ts
@@ -2615,6 +2615,10 @@ export namespace Components {
         "value": string;
     }
     interface CalciteInputTimeZone {
+        /**
+          * When `true`, an empty value (`null`) will be allowed as a `value`.  When `false`, an offset or name value is enforced, and clearing the input or blurring will restore the last valid `value`.
+         */
+        "clearable": boolean;
         /**
           * When `true`, interaction is prevented and the component is displayed with lower opacity.
          */
@@ -10091,6 +10095,10 @@ declare namespace LocalJSX {
         "value"?: string;
     }
     interface CalciteInputTimeZone {
+        /**
+          * When `true`, an empty value (`null`) will be allowed as a `value`.  When `false`, an offset or name value is enforced, and clearing the input or blurring will restore the last valid `value`.
+         */
+        "clearable"?: boolean;
         /**
           * When `true`, interaction is prevented and the component is displayed with lower opacity.
          */
diff --git a/packages/calcite-components/src/components/input-time-zone/assets/input-time-zone/t9n/messages.json b/packages/calcite-components/src/components/input-time-zone/assets/input-time-zone/t9n/messages.json
index 477bb116d51..93a716c624d 100644
--- a/packages/calcite-components/src/components/input-time-zone/assets/input-time-zone/t9n/messages.json
+++ b/packages/calcite-components/src/components/input-time-zone/assets/input-time-zone/t9n/messages.json
@@ -1,5 +1,7 @@
 {
   "chooseTimeZone": "Choose time zone.",
+  "offsetPlaceholder": "Search by city, region or offset",
+  "namePlaceholder": "Search by time zone",
   "timeZoneLabel": "({offset}) {cities}",
   "Africa/Abidjan": "Abidjan",
   "Africa/Accra": "Accra",
diff --git a/packages/calcite-components/src/components/input-time-zone/assets/input-time-zone/t9n/messages_en.json b/packages/calcite-components/src/components/input-time-zone/assets/input-time-zone/t9n/messages_en.json
index 477bb116d51..93a716c624d 100644
--- a/packages/calcite-components/src/components/input-time-zone/assets/input-time-zone/t9n/messages_en.json
+++ b/packages/calcite-components/src/components/input-time-zone/assets/input-time-zone/t9n/messages_en.json
@@ -1,5 +1,7 @@
 {
   "chooseTimeZone": "Choose time zone.",
+  "offsetPlaceholder": "Search by city, region or offset",
+  "namePlaceholder": "Search by time zone",
   "timeZoneLabel": "({offset}) {cities}",
   "Africa/Abidjan": "Abidjan",
   "Africa/Accra": "Accra",
diff --git a/packages/calcite-components/src/components/input-time-zone/input-time-zone.e2e.ts b/packages/calcite-components/src/components/input-time-zone/input-time-zone.e2e.ts
index 6beb2983b38..c5ca280a48a 100644
--- a/packages/calcite-components/src/components/input-time-zone/input-time-zone.e2e.ts
+++ b/packages/calcite-components/src/components/input-time-zone/input-time-zone.e2e.ts
@@ -1,4 +1,4 @@
-import { newE2EPage } from "@stencil/core/testing";
+import { E2EElement, E2EPage, newE2EPage } from "@stencil/core/testing";
 import { html } from "../../../support/formatting";
 import {
   accessible,
@@ -304,25 +304,106 @@ describe("calcite-input-time-zone", () => {
     });
   });
 
-  it("does not allow users to deselect a time zone offset", async () => {
-    const page = await newE2EPage();
-    await page.emulateTimezone(testTimeZoneItems[0].name);
-    await page.setContent(
-      addTimeZoneNamePolyfill(html`
-        <calcite-input-time-zone value="${testTimeZoneItems[1].offset}" open></calcite-input-time-zone>
-      `),
-    );
-    await page.waitForChanges();
+  describe("clearable", () => {
+    it("does not allow users to deselect a time zone value by default", async () => {
+      const page = await newE2EPage();
+      await page.emulateTimezone(testTimeZoneItems[0].name);
+      await page.setContent(
+        addTimeZoneNamePolyfill(html`
+          <calcite-input-time-zone value="${testTimeZoneItems[1].offset}" open></calcite-input-time-zone>
+        `),
+      );
+      await page.waitForChanges();
+
+      let selectedTimeZoneItem = await page.find("calcite-input-time-zone >>> calcite-combobox-item[selected]");
+      await selectedTimeZoneItem.click();
+      await page.waitForChanges();
+
+      selectedTimeZoneItem = await page.find("calcite-input-time-zone >>> calcite-combobox-item[selected]");
+      const input = await page.find("calcite-input-time-zone");
+
+      expect(await input.getProperty("value")).toBe(`${testTimeZoneItems[1].offset}`);
+      expect(await selectedTimeZoneItem.getProperty("textLabel")).toMatch(testTimeZoneItems[1].label);
+
+      input.setProperty("value", "");
+      await page.waitForChanges();
+
+      selectedTimeZoneItem = await page.find("calcite-input-time-zone >>> calcite-combobox-item[selected]");
+      expect(await input.getProperty("value")).toBe(`${testTimeZoneItems[1].offset}`);
+      expect(await selectedTimeZoneItem.getProperty("textLabel")).toMatch(testTimeZoneItems[1].label);
+    });
 
-    let selectedTimeZoneItem = await page.find("calcite-input-time-zone >>> calcite-combobox-item[selected]");
-    await selectedTimeZoneItem.click();
-    await page.waitForChanges();
+    describe("clearing by value", () => {
+      let page: E2EPage;
+      let input: E2EElement;
 
-    selectedTimeZoneItem = await page.find("calcite-input-time-zone >>> calcite-combobox-item[selected]");
-    const input = await page.find("calcite-input-time-zone");
+      beforeEach(async () => {
+        page = await newE2EPage();
+        await page.emulateTimezone(testTimeZoneItems[0].name);
+        await page.setContent(
+          addTimeZoneNamePolyfill(
+            html` <calcite-input-time-zone value="${testTimeZoneItems[1].offset}" clearable></calcite-input-time-zone>`,
+          ),
+        );
+        input = await page.find("calcite-input-time-zone");
+      });
+
+      it("empty string", async () => {
+        await input.setProperty("value", "");
+        await page.waitForChanges();
+
+        expect(await input.getProperty("value")).toBe("");
+      });
 
-    expect(await input.getProperty("value")).toBe(`${testTimeZoneItems[1].offset}`);
-    expect(await selectedTimeZoneItem.getProperty("textLabel")).toMatch(testTimeZoneItems[1].label);
+      it("null", async () => {
+        await input.setProperty("value", null);
+        await page.waitForChanges();
+
+        expect(await input.getProperty("value")).toBe("");
+      });
+    });
+
+    it("allows users to deselect a time zone value when clearable is enabled", async () => {
+      const page = await newE2EPage();
+      await page.emulateTimezone(testTimeZoneItems[0].name);
+      await page.setContent(
+        addTimeZoneNamePolyfill(
+          html`<calcite-input-time-zone value="${testTimeZoneItems[1].offset}" clearable></calcite-input-time-zone>`,
+        ),
+      );
+
+      const input = await page.find("calcite-input-time-zone");
+      await input.callMethod("setFocus");
+
+      expect(await input.getProperty("value")).toBe(`${testTimeZoneItems[1].offset}`);
+
+      await input.press("Escape");
+      await page.waitForChanges();
+
+      expect(await input.getProperty("value")).toBe("");
+    });
+
+    it("can be cleared on initialization when clearable is enabled", async () => {
+      const page = await newE2EPage();
+      await page.emulateTimezone(testTimeZoneItems[0].name);
+      await page.setContent(
+        addTimeZoneNamePolyfill(html`<calcite-input-time-zone value="" clearable></calcite-input-time-zone>`),
+      );
+
+      const input = await page.find("calcite-input-time-zone");
+      expect(await input.getProperty("value")).toBe("");
+    });
+
+    it("selects user time zone value when value is not set and clearable is enabled", async () => {
+      const page = await newE2EPage();
+      await page.emulateTimezone(testTimeZoneItems[0].name);
+      await page.setContent(
+        addTimeZoneNamePolyfill(html`<calcite-input-time-zone clearable></calcite-input-time-zone>`),
+      );
+
+      const input = await page.find("calcite-input-time-zone");
+      expect(await input.getProperty("value")).toBe(`${testTimeZoneItems[0].offset}`);
+    });
   });
 
   describe("selection of subsequent items with the same offset", () => {
@@ -392,21 +473,21 @@ describe("calcite-input-time-zone", () => {
     const inputTimeZone = await page.find("calcite-input-time-zone");
 
     let prevComboboxItem = await page.find("calcite-input-time-zone >>> calcite-combobox-item");
-    await inputTimeZone.setProperty("lang", "es");
+    inputTimeZone.setProperty("lang", "es");
     await page.waitForChanges();
 
     let currComboboxItem = await page.find("calcite-input-time-zone >>> calcite-combobox-item");
     expect(currComboboxItem).not.toBe(prevComboboxItem);
 
     prevComboboxItem = currComboboxItem;
-    await inputTimeZone.setProperty("referenceDate", "2021-01-01");
+    inputTimeZone.setProperty("referenceDate", "2021-01-01");
     await page.waitForChanges();
 
     currComboboxItem = await page.find("calcite-input-time-zone >>> calcite-combobox-item");
     expect(currComboboxItem).not.toBe(prevComboboxItem);
 
     prevComboboxItem = currComboboxItem;
-    await inputTimeZone.setProperty("mode", "list");
+    inputTimeZone.setProperty("mode", "list");
     await page.waitForChanges();
 
     currComboboxItem = await page.find("calcite-input-time-zone >>> calcite-combobox-item");
diff --git a/packages/calcite-components/src/components/input-time-zone/input-time-zone.stories.ts b/packages/calcite-components/src/components/input-time-zone/input-time-zone.stories.ts
index 258c358dc12..d531daaba8c 100644
--- a/packages/calcite-components/src/components/input-time-zone/input-time-zone.stories.ts
+++ b/packages/calcite-components/src/components/input-time-zone/input-time-zone.stories.ts
@@ -25,6 +25,18 @@ export const simple = (): string => html`
   ></calcite-input-time-zone>
 `;
 
+export const clearable = (): string => html`
+  <label>default</label>
+  <calcite-input-time-zone mode="offset" clearable></calcite-input-time-zone>
+  <calcite-input-time-zone mode="name" clearable></calcite-input-time-zone>
+  <br />
+  <label>initialized as empty</label>
+  <calcite-input-time-zone mode="offset" clearable value=""></calcite-input-time-zone>
+  <calcite-input-time-zone mode="name" clearable value=""></calcite-input-time-zone>
+`;
+
+clearable.parameters = { chromatic: { delay: 500 } };
+
 export const timeZoneNameMode_TestOnly = (): string => html`
   <calcite-input-time-zone mode="name" open></calcite-input-time-zone>
 `;
diff --git a/packages/calcite-components/src/components/input-time-zone/input-time-zone.tsx b/packages/calcite-components/src/components/input-time-zone/input-time-zone.tsx
index b63a8c38a2c..a1368270f3b 100644
--- a/packages/calcite-components/src/components/input-time-zone/input-time-zone.tsx
+++ b/packages/calcite-components/src/components/input-time-zone/input-time-zone.tsx
@@ -77,6 +77,13 @@ export class InputTimeZone
   //
   //--------------------------------------------------------------------------
 
+  /**
+   * When `true`, an empty value (`null`) will be allowed as a `value`.
+   *
+   * When `false`, an offset or name value is enforced, and clearing the input or blurring will restore the last valid `value`.
+   */
+  @Prop({ reflect: true }) clearable = false;
+
   /**
    * When `true`, interaction is prevented and the component is displayed with lower opacity.
    */
@@ -188,6 +195,14 @@ export class InputTimeZone
 
   @Watch("value")
   handleValueChange(value: string, oldValue: string): void {
+    value = this.normalizeValue(value);
+
+    if (!value && this.clearable) {
+      this.value = value;
+      this.selectedTimeZoneItem = null;
+      return;
+    }
+
     const timeZoneItem = this.findTimeZoneItem(value);
 
     if (!timeZoneItem) {
@@ -302,7 +317,17 @@ export class InputTimeZone
   private onComboboxChange = (event: CustomEvent): void => {
     event.stopPropagation();
     const combobox = event.target as HTMLCalciteComboboxElement;
-    const selected = this.findTimeZoneItemByLabel(combobox.selectedItems[0].textLabel);
+    const selectedItem = combobox.selectedItems[0];
+
+    if (!selectedItem) {
+      this.value = null;
+      this.selectedTimeZoneItem = null;
+      this.calciteInputTimeZoneChange.emit();
+      return;
+    }
+
+    const selected = this.findTimeZoneItemByLabel(selectedItem.textLabel);
+
     const selectedValue = `${selected.value}`;
 
     if (this.value === selectedValue && selected.label === this.selectedTimeZoneItem.label) {
@@ -326,25 +351,27 @@ export class InputTimeZone
     this.calciteInputTimeZoneOpen.emit();
   };
 
-  private findTimeZoneItem(value: number | string): TimeZoneItem {
+  private findTimeZoneItem(value: number | string | null): TimeZoneItem | null {
     return findTimeZoneItemByProp(this.timeZoneItems, "value", value);
   }
 
-  private findTimeZoneItemByLabel(label: string): TimeZoneItem {
+  private findTimeZoneItemByLabel(label: string | null): TimeZoneItem | null {
     return findTimeZoneItemByProp(this.timeZoneItems, "label", label);
   }
 
   private async updateTimeZoneItemsAndSelection(): Promise<void> {
     this.timeZoneItems = await this.createTimeZoneItems();
 
+    if (this.value === "" && this.clearable) {
+      this.selectedTimeZoneItem = null;
+      return;
+    }
+
     const fallbackValue = this.mode === "offset" ? getUserTimeZoneOffset() : getUserTimeZoneName();
     const valueToMatch = this.value ?? fallbackValue;
 
-    this.selectedTimeZoneItem = this.findTimeZoneItem(valueToMatch);
-
-    if (!this.selectedTimeZoneItem) {
-      this.selectedTimeZoneItem = this.findTimeZoneItem(fallbackValue);
-    }
+    this.selectedTimeZoneItem =
+      this.findTimeZoneItem(valueToMatch) || this.findTimeZoneItem(fallbackValue);
   }
 
   private async createTimeZoneItems(): Promise<TimeZoneItem[]> {
@@ -382,13 +409,18 @@ export class InputTimeZone
     disconnectMessages(this);
   }
 
+  private normalizeValue(value: string | null): string {
+    return value === null ? "" : value;
+  }
+
   async componentWillLoad(): Promise<void> {
     setUpLoadableComponent(this);
     await setUpMessages(this);
+    this.value = this.normalizeValue(this.value);
 
     await this.updateTimeZoneItemsAndSelection();
 
-    const selectedValue = `${this.selectedTimeZoneItem.value}`;
+    const selectedValue = this.selectedTimeZoneItem ? `${this.selectedTimeZoneItem.value}` : null;
     afterConnectDefaultValueSet(this, selectedValue);
     this.value = selectedValue;
   }
@@ -406,7 +438,7 @@ export class InputTimeZone
       <Host>
         <InteractiveContainer disabled={this.disabled}>
           <calcite-combobox
-            clearDisabled={true}
+            clearDisabled={!this.clearable}
             disabled={this.disabled}
             label={this.messages.chooseTimeZone}
             lang={this.effectiveLocale}
@@ -418,9 +450,12 @@ export class InputTimeZone
             onCalciteComboboxOpen={this.onComboboxOpen}
             open={this.open}
             overlayPositioning={this.overlayPositioning}
+            placeholder={
+              this.mode === "name" ? this.messages.namePlaceholder : this.messages.offsetPlaceholder
+            }
             readOnly={this.readOnly}
             scale={this.scale}
-            selectionMode="single-persist"
+            selectionMode={this.clearable ? "single" : "single-persist"}
             status={this.status}
             validation-icon={this.validationIcon}
             validation-message={this.validationMessage}
diff --git a/packages/calcite-components/src/components/input-time-zone/utils.ts b/packages/calcite-components/src/components/input-time-zone/utils.ts
index b5a0e5d5fbf..a432bca1ecc 100644
--- a/packages/calcite-components/src/components/input-time-zone/utils.ts
+++ b/packages/calcite-components/src/components/input-time-zone/utils.ts
@@ -175,11 +175,13 @@ function getTimeZoneShortOffset(
 export function findTimeZoneItemByProp(
   timeZoneItems: TimeZoneItem[],
   prop: string,
-  valueToMatch: string | number,
-): TimeZoneItem {
-  return timeZoneItems.find(
-    (item) =>
-      // intentional == to match string to number
-      item[prop] == valueToMatch,
-  );
+  valueToMatch: string | number | null,
+): TimeZoneItem | null {
+  return valueToMatch == null
+    ? null
+    : timeZoneItems.find(
+        (item) =>
+          // intentional == to match string to number
+          item[prop] == valueToMatch,
+      );
 }
diff --git a/packages/calcite-components/src/demos/input-time-zone.html b/packages/calcite-components/src/demos/input-time-zone.html
index 73b144fce2d..67ef2607bea 100644
--- a/packages/calcite-components/src/demos/input-time-zone.html
+++ b/packages/calcite-components/src/demos/input-time-zone.html
@@ -62,6 +62,21 @@ <h1 style="margin: 0 auto; text-align: center">Select</h1>
         </div>
       </div>
 
+      <div class="parent">
+        <div class="child right-aligned-text">Basic (offset mode, clearable)</div>
+        <div class="child">
+          <calcite-input-time-zone scale="s" clearable></calcite-input-time-zone>
+        </div>
+
+        <div class="child">
+          <calcite-input-time-zone scale="m" clearable></calcite-input-time-zone>
+        </div>
+
+        <div class="child">
+          <calcite-input-time-zone scale="l" clearable></calcite-input-time-zone>
+        </div>
+      </div>
+
       <div class="parent">
         <div class="child right-aligned-text">Basic (offset mode) + readonly</div>
         <div class="child">
@@ -136,6 +151,21 @@ <h1 style="margin: 0 auto; text-align: center">Select</h1>
           <calcite-input-time-zone scale="l" mode="name"></calcite-input-time-zone>
         </div>
       </div>
+
+      <div class="parent">
+        <div class="child right-aligned-text">name mode (clearable)</div>
+        <div class="child">
+          <calcite-input-time-zone scale="s" mode="name" clearable></calcite-input-time-zone>
+        </div>
+
+        <div class="child">
+          <calcite-input-time-zone scale="m" mode="name" clearable></calcite-input-time-zone>
+        </div>
+
+        <div class="child">
+          <calcite-input-time-zone scale="l" mode="name" clearable></calcite-input-time-zone>
+        </div>
+      </div>
     </demo-dom-swapper>
   </body>
 </html>